Kornimate/medical-research-clean huggingface dataset:
a single center study of post-operative stereotactic radiotherapy for endometrial cancer

Conditions: Endometrial Cancer

Summary: the primary endpoint of the present prospective study is to assess the outcomes in terms of acute toxicity of post-operative stereotactic radiotherapy for endometrial cancer

endometrial cancer represents the sixth global female cancer, and adjuvant radiotherapy has a main role in the management of these patients. this treatment usually covers the surgical bed, the upper portion of the vagina and the pelvic lymph nodes. in the last decades, the technological progress has allowed clinicians to offer a more accurate planning and delivery of the treatment with modern imrt-igrt techniques. nonetheless, radiotherapy regimens were still based on 25-30 fractions schedules. more recently, similarly to other oncological settings like prostate, breast or rectal cancer, 5-fractions schedules have been considered as potentially useful also in this setting. on this purpose, this study aims to investigate the feasibility of a shorter adjuvant radiotherapy treatment for endometrial cancer, by assessing acute and late toxicity, quality of life and clinical outcomes.

Eligibility criteria:
* age 18-80 years * ecog ps ≤ 2 or kps ≥ 70% * patients diagnosed with endometrial cancer (endometrioid, serous cell, clear cell, carcinosarcoma) figo stage ib-iiic1 candidate to post-operative external beam radiotherapy, based on molecular and histological findings * indications for chemotherapy and/or brachytherapy are not exclusion criteria for the purpose of the study * written informed consent exclusion criteria: * prior pelvic radiotherapy * para-aortic lymph nodes involvement * ecog ps ≥ 3 * any diagnosis of inflammatory bowel disease (both active or quiescent)

Keywords: endometrial cancer radiotherapy sbrt
assess the prognostic usefulness of flutemetamol (18f) injection for identifying subjects with amnestic mild cognitive impairment who will convert to clinically probable alzheimer's disease

Conditions: Mild Cognitive Impairment; Alzheimer's Disease

Summary: this study will investigate the efficacy of the flutemetamol (18f) injection pet tracer in identifying abnormal (18f) flutemetamol uptake patterns which predict the conversion from amci to a b-amyloid associated clinically probable alzheimer's disease.


Eligibility criteria:
inclusion criteria: * the subject is 60 years old or older. * the subject meets the petersen criteria for amnestic mci. * the subject has a score of less than or equal to 4 on the modified hachinski ischemic scale. * the subject has a mmse score of 24-30. * the subject has a non-contrast mri examination as part of the screening visit that excludes amci arising from structural causes. * the subject and/or the subject's legally acceptable representative, if applicable, in accordance with local regulations, has signed and dated an informed consent. exclusion criteria: * the subject has any significant neurologic disease other than suspected amci; such as parkinson's disease, huntington's disease, normal pressure hydrocephalus, brain tumor, supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurologic deficits, or known structural brain abnormalities. * the subject has one or more aneurysm clips, artificial heart valves, metal implants, embedded metal fragments or pacemakers that would pose a risk during an mri. * the subject has major depression, bipolar disorder, as described in the dsm-iv within the past year. * the subject has history of schizophrenia (dsm-iv criteria). * the subject has had, within the prior 3 months, psychotic features, agitation or behavioral problems that could lead to protocol compliance issues.

Keywords: mild cognitive impairment positron emission tomography national institute of neurological and communicative disorders and stroke alzheimer's disease and related disorders association assess prognostic usefulness of flutemetamol injection for identifying subjects who will convert to clinically probable alzheimer's disease
cushing´s disease epidemiology in sweden

Conditions: Cushing Disease

Summary: the purpose of this study is to study since 1987 all patients diagnosed with cd in sweden and determine their outcomes including mortality. a secondary objective is to focus on patients in remission and identify determinants of their different outcomes.

this study is a retrospective nationwide study of all patients in sweden with diagnosis cd between 1987 and 2013 were baseline data at diagnosis, information about the different treatments and follow-up data is going to be obtained by reviewing patients' medical journals. this information as well as the exact diagnose criteria for each patient are going to be extracted by endocrinologists in all university hospitals in sweden. an expert group at the sahlgrenska university hospital in gothenburg will put together the data.by the use of the swedish personal number, the investigators are going to obtain information about both patients' and background population co-morbidities which have been collected in the different swedish registers. primary aim: to study mortality of cd in sweden. secondary aims: 1. to study the influence of cd on myocardial infarction 2. to study the influence of cd on stroke 3. to study the influence of cd on cancer 4. to study the influence of cd on hip fracture risk 5. to study incidence and prevalence of cd in sweden.

Eligibility criteria:
inclusion criteria: * all patients registered with cushing's disease in sweden since 1987 in the statistical database for in- and out-patients, at the swedish national board of health and welfare will be included in the study. exclusion criteria: * no

Keywords: mortality morbidity incidence prevalence
xenogenic collagen matrix for the treatment of multiple gingival recessions

Conditions: Gingival Recession, Generalized

Summary: the primary aim of this study is to evaluate whether the use of a xenogenic collagen matrix (xcm) for the treatment of multiple adjacent gingival recessions (magrs) with a multiple coronally advanced flap technique (mcaf) achieves better results than the use of an autologous connective tissue graft (ctg) in terms of recession reduction (primary outcome) and other secondary root coverage outcomes (e.g. complete root coverage, mean root coverage). moreover, this study aims to compare secondary clinical variables (e.g. keratinized tissue width (ktw) changes, probing pocket depth (ppd) changes, volumetric gain (vg), etc.), also with a digital approach, the patient-reported outcome measures (proms e.g. pain, swelling, bleeding). the hypothesis of this study is that at 6 months and 1 year follow-up the mcaf with xcm is not inferior to ctg in terms of recessions reduction and secondary clinical variables, and superior regarding to proms.


Eligibility criteria:
inclusion criteria: * at least 18 years old and able to sign informed consent * at least 2 adjacent teeth with rt1 and/or rt2 gingival recessions without interproximal exposure of the cej (interdental gingival recession), at least one with a depth of ≥2mm with indication for root coverage treatment * a minimum of 4 adjacent teeth (including the ones to be treated) in the region of interest * available to attend study related procedures (including follow-up visits) exclusion criteria: * systemic diseases/medications which could influence the outcome of the therapy (e.g., uncontrolled diabetes mellitus); * current smokers (self-reported, any type of smoking), users of chewing tobacco, and drug/alcohol abusers; * pregnant or nursing women; * history of previous periodontal surgery (mucogingival or other) on the teeth to be included; * furcation involvement in the teeth to be included; * presence of severe tooth malposition, rotation or clinically significant extrusion in the teeth to be treated; * presence of fixed or removable prosthesis in the area to be treated
continuous quality improvement (cqi) pilot study evaluating the utility of an educational video

Conditions: Actinic Keratoses

Summary: the primary aim of this study is to evaluate the effects of prospective patient education on patient satisfaction with administration of topical 5% 5-fluorouracil cream for the treatment of actinic keratosis involving the face, scalp, upper chest, dorsal hands and forearms. specifically, this study aims to determine if prospective patient viewing of an educational video delineating treatment effects and expectations improves patient satisfaction and treatment completion rates.


Eligibility criteria:
inclusion criteria: * subjects with a clinical diagnosis of actinic keratoses with at least 6 clinically-diagnosed actinic keratoses on the face, bald scalp, arms, upper chest, or dorsal hands classified as grade i, mild (slightly palpable actinic keratoses, more easily felt than seen), and ii, moderate (moderately thick hyperkeratotic actinic keratoses, easily felt). exclusion criteria: * patients using interferon or interferon inducers, immunomodulators, cytotoxic or immunosuppressor drugs, corticosteroids, retinoids, or investigational drugs within 4 weeks prior to enrollment. * patients who have been treated with any topical drug for actinic keratoses lesions less than 8 weeks prior to enrollment. * patients with invasive tumors within the treated area (e.g. invasive squamous cell carcinoma) * patients who have exhibited any dermatological disease within the treated or adjacent (3 cm distance) area at the time of screening. * patients who have known allergies to fluorouracil (5-fu).
pelvic floor disorders in multiple sclerosis patients

Conditions: Multiple Sclerosis

Summary: primary objective 1. clinical assessment of bowel, bladder, and sexual dysfunction in patients with ms 2. impact of sphincter disorders on quality of life in patients with ms by using correlation between extended disability status scale (edss)and the incontinence quality of life questionnaire (iqol) secondary objectives -studying the effect of low frequency rtms on bladder symptoms in patients with ms.

2.4.1- type of the study: this study will be a cross-section observational study. 2.4. 2- study setting: neuology unit assuit university hospital 2.4. 3- study subjects: from the neurologic outpatient clinic in assiut university and patients referred from our staff members in neuropsychiatry department. 1. inclusion criteria: adult patient with definite multiple sclerosis according to mcdonald's criteria (revised criteria 2017), age \> 18 years both sexes patient with subjective complaint of any of pelvic floor dysfunction (bladder, sexual or bowel) 2. exclusion criteria: patients with other systemic or neurological disorder affecting sphincter (diabetes mellitus, renal diseases, urinary tract infection, epilepsy, peripheral neuropathy, irritable bowel syndrome.....) patients taking drugs affecting sphincter as psychotropic drugs 2.4.4 -study tools (in detail, e.g., lab methods, instruments, steps, chemicals, ...): step i patients will be assessed through full neurological history and examination with all of them will be subjected to the following scales: * extended disability status scale (edss) * multiple sclerosis quality of life inventory (msqli) * actionable bladder symptom screening tool (absst) * neurogenic bladder symptom score (nbss) * the incontinence quality of life questionnaire (iqol) * neurogenic bowel dysfunction score (nbd) * multiple sclerosis intimacy and sexuality questionnaire 19-item version (msisq-19) step ii all patients will have the paraclinical assessment in form of neuroimaging (recent mri brain and spine within last year) evoked potentials (visual, auditory brainstem) motor evoked potential using tms with parameters gained using single pulse paradigm step iii as a fulfillment for our secondary objective regarding the study of the effect of rtms on urinary dysfunction we will recruit 20 patients with significant urinary dysfunction according to assessment results with edss ≤ 6 and they will be randomized in two arms for active and sham application of rtms. by using high intensity low frequency protocol for rtms application\[39\] for 10 sessions over two weeks with using voiding diary, specific selected scales and selected cortical excitability measures as assessment tools, we will follow up the patients immediately and for one month post sessions.

Eligibility criteria:
inclusion criteria: 1.adult patient with definite multiple sclerosis 2-age \> 18 years 3-both sexes 4-patient with complaint of any of pelvic floor dysfunction (bladder, sexual or bowel) exclusion criteria: 1. patients with other systemic or neurological disorder affecting sphincter. 2. patients taking drugs affecting sphincter.
long-term results of pediatric flexor tendon injuries

Conditions: Hand Injuries; Flexor Tendon Injury

Summary: hand and upper extremity injuries are among the most common causes of admission of children to the emergency department since they are the most frequently injured part of body following head in pediatric and adolescent population. although upper extremity fractures and contusions are the main reasons of pediatric hand injuries, tendon injuries are not also uncommon. there are limited data in the literature about the long-term results of children with flexor tendon injury. therefore, the aim of this study was to evaluate the long-term functional outcomes of children with flexor tendon injury.

hand and upper extremity injuries are among the most common causes of admission of children to the emergency department since they are the most frequently injured part of body following head in pediatric and adolescent population. although upper extremity fractures and contusions are the main reasons of pediatric hand injuries, tendon injuries are not also uncommon. while extensor tendon injuries have been reported to be most frequent than flexor tendon injuries for all age groups, the ratio of flexor to extensor tendon injuries is higher in pediatric population than adults and in children younger than 10 years old flexor tendon injuries are more common than extensor tendon injuries.despite some challenges in the treatment of flexor tendon injuries of children, the outcomes have been reported to be better in children than adults since they have better blood supply, more rapid tendon healing and better remodeling ability of scars and adhesions. however, there is still a risk of permanent morbidities such as significant scarring and stiffness which can cause worse functional outcomes.there are limited data in the literature about the long-term results of children with flexor tendon injury. therefore, the aim of this study was to evaluate the long-term functional outcomes of children with flexor tendon injury.

Eligibility criteria:
inclusion criteria: * . patients between the ages of 6-18 who have applied to orthopedics emergency department due to hand injury and have been operated with flexor tendon injury, for the last 3 years exclusion criteria: * the patients who had history of bilateral hand injury, delayed surgery, accompanying extensor tendon injury and a follow-up less than six months after injury were excluded from the study.

Keywords: flexor tendons children functional outcome hand injury
a phase 2 study of vvn461 ophthalmic solution for noninfectious anterior uveitis

Conditions: Anterior Uveitis

Summary: this is a multicenter, double-masked, randomized, active-controlled, parallel-comparison study conducted at sites in the china in subjects with noninfectious anterior uveitis

in this study, subjects who meet the inclusion/exclusion criteria will be randomized to receive one of the three treatments prednisolone acetate during the screening/baseline visit (day-2 to day 1). starting from visit 1 (day 1), subjects will be administered one drop of the investigational product in the study eye in following dose regimens: 6 times per day (q2h, 2 hours apart) for 7 days; 4 times per day (qid) for 7 days；2 times per day (bid) for 7 days；once a day (qd) for 7 days. subjects will return to clinic for study assessments on day 3 (visit 2), day 7 (visit 3), day 14 (visit 4), day 21 (visit 5) and day 28 (visit 6, end of study) or early withdrawal/termination visit.

Eligibility criteria:
inclusion criteria: * age 18-70 years at the time providing signed informed consent * at least 1 eye diagnosed with noninfectious anterior uveitis at the time of screening * willing and able to comply with study requirements and visit schedule exclusion criteria: * diagnosis of intermediate uveitis, posterior uveitis or panuveitis in either eye at the time of screening
a prospective study of the complement depletion in patients with severe abdominal sepsis

Conditions: Severe Sepsis; Pancreatitis; Abdominal Abscess; Appendicitis; Digestive System Fistula

Summary: the role of complement system in bridging innate and adaptive immunity has been confirmed in various invasive pathogens. the aim of this study is to investigate the alteration of complement c3 in patients with severe abdominal sepsis and evaluate the role of complement c3 depletion in prognosis of such patients. the relationship between complement c3 depletion and adaptive immunity is studied meanwhile.

severe abdominal sepsis remains a significant cause of death in patients undergoing intra-abdominal infection, in despite of recent declines in overall mortality. there is a abundant evidence to suggest complement activation during sepsis. while there is great interest in complement by-products in human sepsis, few studies focus on the persistent consumption of complement components and its role in prognosis of sepsis. complement c3 is indispensable community pathway for complement activation. in a way, the alteration of c3 levels can affect the whole status of complement biological functions. in clinical practice, the severe abdominal sepsis would develop compromised immune function if the intra-abdominal infection is not well controlled. the down-regulated t- and b-cell immune responses to sepsis are correlated to the decreased immune defense. to our knowledge, there are few human data that have investigated the relationship between complement depletion and adaptive immunity in severe abdominal sepsis. the investigators hypothesize that the complement c3 depletion during sepsis has a stronger association with the down-regulated adaptive immunity and can be regarded as a essential risk factor to predict the prognosis of such critical illness. the purpose of this prospective study is two-fold. first, the investigators observe, in a cohort of patients with severe abdominal sepsis, the levels of complement components and percentages of t cell subsets after admission to evaluate the relationship between complement system and adaptive immunity. second, the investigators also evaluate the application of the c3 related-indexes (c3, c3a, factor h, daf, etc.) to patients undergoing severe abdominal sepsis and to develop an alternative model to predict its prognosis.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of severe abdominal sepsis exclusion criteria: * age \ 60 years * pregnancy * leucopenia from radiochemical therapy due to malignant tumor * any primary diagnosis other than sepsis * confirmed immunodeficiency * requirement for blood transfusion, plasmapheresis, or immediate surgery
pain management in primary intervention of the mobile emergency and resuscitation service

Conditions: Pain

Summary: the aim of the study is to carry out an inventory of practices relating to the management of pain: its recognition, assessment and treatment.

pain is one of the most frequent reasons for seeking emergency care, with a prevalence of approximately 42% in pre-hospital care. pain management practices are defined by the french society of anaesthesia and intensive care (sfar) and the french society of emergency medicine (sfmu). pain must be systematically managed and treated. to do this, it is necessary to start by assessing the pain using self-assessment scales, the vas (visual analogue pain scale) or the en (numerical pain scale) being the two validated scales. depending on the intensity of the pain, appropriate treatments should be prescribed: * if en \< 6: level i or ii analgesic * if en \> 6: morphine titration finally, after the treatment has been implemented, the pain must be re-evaluated using the same self-assessment scales in order to attest to the effectiveness of the treatment. there is a lack of knowledge of the recommendations for pain management and assessment: 49% of smur doctors do not know the sfar recommendations and only 17% define severe acute pain by a vas or ens greater than 6/10. the aim of the study is to carry out an inventory of practices relating to the management of pain: its recognition, assessment and treatment and to check whether pain management was carried out according to the recommendations of the french society of anaesthesia and intensive care (sfar) and the french society of emergency medicine (sfmu).

Eligibility criteria:
inclusion criteria : * patients over 18 years of age, * patient managed on primary intervention file between 01/11 and 30/11/2021, between 01/03 and 31/03/2022 or between 01/08 and 31/08/2022, * patient transferred to novo hospital (pontoise, beaumont-sur-oise or magny en vexin site) for further medical care. exclusion criteria : * patient in cardiorespiratory arrest (cra), * patient in coma, * patient without applicant, * patient who has expressed his opposition to the collect of his data.

Keywords: pain management emergency care mobile emergency and resuscitation service
the impact of preoperative anemia on postoperative anemia and related nutrient abnormalities after bariatric surgery

Conditions: Anemia; Bariatric Surgery

Summary: this study aims to assess the impact of preoperative anemia status on anemia and related nutrient abnormalities 1 year after bariatric surgery.

this study aims to assess the impact of preoperative anemia status on anemia and related nutrient abnormalities (ferritin deficiency, vitamin b12 deficiency, folate deficiency, and low transferrin saturation level) at 1 year after bariatric surgery.

Eligibility criteria:
inclusion criteria: * patients who underwent bariatric surgery (sleeve gastrectomy and roux-en-y gastric bypass) * age between 16 and 70 years * patients who have complete 1-year follow-up data exclusion criteria: * baseline renal failure * vegetarian * postoperative bleeding (it was defined as a drop in hemoglobin levels \> 3 g/dl or a confirmed blood loss requiring treatment after surgery)