Kornimate/medical-research-clean huggingface dataset:
blood flow restricted electrical stimulation during immobilisation

Conditions: Atrophy, Muscular; Atrophy, Disuse

Summary: following injury or surgery to a limb, it is often immobilised to allow tissue healing. short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced function. strategies to combat these deconditioning adaptations include neuromuscular electrical stimulation (nmes), however at present its effectiveness is limited. recent research suggests that the effects of nmes can be augmented with blood flow restriction (bfr). at present, the effect of combining these two techniques on muscle function during limb immobilisation is unknown. furthermore, the impact of bfr training during retraining following immobilisation is unknown.

following injury or surgery to a limb, it is often immobilised to allow tissue healing. short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced function. strategies to combat these deconditioning adaptations include neuromuscular electrical stimulation (nmes), however at present its effectiveness is limited. recent research suggests that the effects of nmes can be augmented with blood flow restriction (bfr). at present, the effect of combining these two techniques on muscle function during limb immobilisation is unknown. furthermore, the impact of bfr training during retraining following immobilisation is unknown. this study will examine the effectiveness and feasibility of a neuromuscular electrical stimulation and blood flow restriction protocol during a 7 day period of immobilisation. multiple measures across several physiological systems will be obtained.

Eligibility criteria:
inclusion criteria: * between the age of 18-55 * non-smoker * no previous history of cardiovascular, respiratory or neurological problems * not taking anticoagulant medication * injury-free in the 3 months prior to scheduled participation in the study. exclusion criteria: * hypertension (\<140/80) * metal work in-situ * blood diseases or clotting issues * injury or previous injury (\<3 months prior to scheduled participation in the study) * pregnancy

Keywords: immobilisation blood flow restriction neuromuscular electrical stimulation
24-hour urinary aldosterone and endocrine system in obesity

Conditions: Obesity

Summary: the study was aimed at investigating the relationship between hormone parameters and urinary aldosterone levels in 24h within a cohort of overweight and obesity.

subjects were enrolled at the first examination whether they were not taking any medication, including oral contraceptives or drugs for osteoporosis, and free of significant medical illnesses, except obesity. exclusion criteria were history of endocrinological diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), chronic inflammatory diseases, stable known hypertension, angina pectoris, stroke, transient ischemic attack, heart infarction, congenital heart disease, malignancies, chronic inflammatory diseases, renal and liver failure, angina pectoris, myocardial infarction, heart failure, congenital heart diseases, minor and major stroke, and inherited thrombocytopenias and other major malignancies. subjects were examined by means of the medical history, hormonal, metabolic and routine hematochemical parameters. the investigators provided for a clinical baseline evaluation that included extemporaneous ambulatory blood pressure (bp) and a physical assessment of body weight, body mass index (bmi) and waist circumference (wc) as anthropometric parameters.

Eligibility criteria:
inclusion criteria: * overweight or obesity (bmi\> 25 kg/m2) exclusion criteria: * any kind of drug * hypertension * endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.), * chronic inflammatory diseases * renal failure * liver failure * angina pectoris * myocardial infarction and heart failure * genetic heart diseases * thrombocytopenias
propranolol in capillary hemangiomas

Conditions: Hemangioma, Capillary

Summary: the investigators observed that propranolol, a beta-blocker commonly used in children was efficient to control the growth of alarming hemangiomas of the face. the primary objective of this study is to determine the efficiency of 1 month-early treatment of propranolol in infants aged less than 4 months affected by an hemangioma without any consequences on vital or functional structure and not justifying corticosteroids. the secondary objectives are: * the kinetic of the hemangioma evolution in infants treated by propranolol * observance * safety

infantile hemangiomas are frequent vascular tumors (4 à 10 % of the neonates) and correspond to 100 new cases per year in dermatology consultation of the chu of bordeaux. hemangiomas have a characteristic clinical course marked by early proliferation during 3 to 12 months followed by slow and spontaneous involution from 3 to 7 years. occasionally, as well as esthetical damages, hemangiomas may impair vital structures, ulcerate, bleed, or cause high-output cardiac failure or significant structural abnormalities. standard treatments (corticotherapy, interferon, vincristine...) lead to a stagnation of hemangiomas in some cases, but with frequent side effects. we observed that propranolol, a beta-blocker usually used in neonates could lead to a decreased in volume of serious haemangiomas of the face (article published in new england journal of medicine). in this study, we proposed to determine the efficiency of 1 month-early treatment of propranolol in neonates aged less than 4 months affected by non alarming hemangioma and not justifying corticotherapy. this is a double blind randomized placebo controlled study of propranolol. infants will be recruited from the dermatology consultation of chu bordeaux. after verification of eligibility criteria and informed consent of legal surrogates, infants will be randomized to receive either propranolol or either placebo. the infants will be observed during 1 month according to the following visits.

Eligibility criteria:
inclusion criteria: * infant aged less than 4 months * infant with one or more hemangiomas sized more than 1 cm diameter * infant not threatening for vital or functional structure and for which no treatment would be proposed * informed consent * patient with social insurance. exclusion criteria: * alarming hemangioma (s) (complicated forms or localization at risk) * cardiac pathology (cardiac malformation, heart failure, cardiac arrhythmias, pulmonary hypertension) * asthma * bronchopulmonary dysplasia * bronchiolitis * raynaud syndrome * phéochromocytoma * development of serious form of hemangioma (bleeding, necrosis, ulceration, infection, respiratory distress) requiring standard treatment

Keywords: infantile capillary hemangiomas propranolol ultrasonography
maintenance therapy in acute myeloid leukemia (aml) patients

Conditions: Acute Myeloid Leukemia

Summary: the purpose of this study is to determine if revlimid will help maintain patients with acute myeloid leukemia in remission.

at present, the majority of aml patients \>60 years of age that achieve cr and thereafter successfully complete further chemotherapy, are not candidates for allogeneic bone marrow transplantation (allobmt) due to their age. rather, this group of patients is simply observed until relapse occurs. in this age group, the median duration of cr is only \~10 months. the survival of patients \<60 years of age who are not candidates for transplantation (due to donor unavailability), and who are in cr2 or higher is also extremely poor. several lines of evidence suggest that the immune system - and in particular aml specific ctls and nk cells - is capable of recognizing and clearing aml cells.

Eligibility criteria:
inclusion criteria: * diagnosis of acute myeloid leukemia in remission. * able to take aspirin 81mgs daily. exclusion criteria: * pregnant or breast feeding females. * known hypersensitivity to thalidomide. * any prior use of lenalidomide.

Keywords: leukemia remission
juvenile autoimmune necrotizing myopathies

Conditions: Immune-Mediated Necrotizing Myopathy

Summary: autoimmune necrotizing myopathies (ainm) in adult patients are characterized by severity of muscle damage, presence of necrosis with little inflammation on muscle biopsy and anti-hmgcr or anti-srp auto-antibodies. data on ainm in children are currently lacking. the purpose of this study is to specify the characteristics at ainm diagnosis, treatments and evolution of juvenile ainm with anti-hmgcr or anti-srp antibodies.


Eligibility criteria:
inclusion criteria: * ainm histologically proved by predominant muscle fibers necrosis lesions associated with minimal or absent inflammatory lesions * either anti-srp or anti-hmgcr antibodies positivity * disease onset before age 18 exclusion criteria: * seronegative necrotizing myopathies * forms compatible with another type of myositis (e.g. dermatomyositis)

Keywords: autoimmune necrotizing myopathy anti-hmgcr antibodies anti-srp antibodies
manual diaphragm release technique increases tidal volume in elderly

Conditions: Healthy

Summary: question: does manual diaphragm release change kinematics and respiratory function of elderly subjects? design: randomized controlled trial with concealed allocation and double-blinding. participants: 17 volunteers over 60 years old randomized into two groups: 09 in the control group (cg) and 08 in the intervention group (ig). intervention: the manual diaphragm release technique was used on the ig, in two sets of ten deep breaths, with a one minute interval between them. the cg underwent a sham protocol (light touch), with same sets and time of interval. outcome measures: the groups were evaluated using spirometry, manovacuometry and optoelectronic plethysmography (oep), in that order, before and immediately after the intervention.


Eligibility criteria:
inclusion criteria: * over 60 years of age; * a body mass index (bmi) below 30 kg/m2 * non-smokers, self-declared sedentary; * presenting a forced expiratory volume in one second (fev1) and forced vital capacity (fvc) greater than or equal to 80% of predicted; * the ratio between these variables (fev1/fvc) greater than 70% in spirometry exclusion criteria: * showed the inability to understand verbal commands in the evaluation.

Keywords: elderly subjects
art therapy and music reminiscence activity in the prevention of cognitive decline

Conditions: Mild Cognitive Impairment

Summary: the objective of this study is to determine the impact of art therapy and music reminiscence activity on cognition in community living elderly with mild cognitive impairment (dsm v: mild neurocognitive disorder) using a randomized control design. specifically, the structural cerebral changes that occur with the two interventions and the extent to which the therapies may reverse cognitive impairment and/or prevent further cognitive decline, will be determined. the hypothesis is that participants in both active intervention arms will perform better on neuropsychological tests of cognition and will show positive changes on functional imaging studies compared to controls who will not receive any intervention. participants in the interventions will also have positive changes in blood biomarkers, enhanced psychological well-being and reductions in anxiety and depressive symptoms compared to the control group. no a priori hypotheses were developed as to whether art therapy or music reminiscence activity is more effective as the comparison is exploratory.

participants: 90 community-living elderly, with mild cognitive impairment. interventions: participants will be randomized into 3 arms: art therapy, music reminiscence activity or a control arm. sessions will be conducted weekly for 3 months and fortnightly for 6 months. each intervention session will last for 40 minutes. the control group will not receive any intervention and continue their life as usual. assessments: demographic data will be collected at baseline. neuropsychological tests of cognitive functioning will be done at baseline, 3 months and 9 months. anxiety and depressive symptoms will be assessed at the 3 time-points. blood sampling will occur at all time points (except control group, only at baseline and 9 months). participants will also undergo a task-free brain fmri scan at baseline and at 3 months.

Eligibility criteria:
inclusion criteria: * older person between 60 and 85 years of age, living in the community and fulfills the operational criteria/definition of mci: 1. at least one age-education adjusted neuropsychological test z score \<-1.5 2. do not meet dsm v criteria for a major neurocognitive disorder 3. memory/cognitive complaint preferably corroborated by a reliable informant 4. intact activities of daily living * functions independently * does not have dementia * able to travel to the data collection site on their own and participate in the activity exclusion criteria: * those who do not meet the above inclusion criteria (ie. do not have a mci diagnosis) * those with dementia/major neurocognitive disorder or normal ageing * presence of a neurological condition e.g. epilepsy, parkinson disease, stroke * presence of a major psychiatric disorder e.g. major depression, psychoses * terminal illness e.g. cancer * presence of significant visual and/or hearing impairment and color blindness * participants in another intervention study at the same time

Keywords: prevention of cognitive decline art therapy music reminiscence activity elderly
comparative trial of entecavir versus adefovir in the treatment of chronic hepatitis b infection

Conditions: Hepatitis B; Chronic Disease

Summary: the purpose of this study is to evaluate antiviral activity and efficacy of entecavir (etv) compared to adefovir in adults with chronic hepatitis b who have not been treated yet with an antiviral medicine.


Eligibility criteria:
inclusion criteria: * chronic hepatitis b treatment naive * compensated liver disease

Keywords: chronic hepatitis b infection
corticosteroid therapy in refractory shock following cardiac arrest

Conditions: Cardiac Arrest

Summary: the major goal of this project is to determine whether the use of physiologic doses of corticosteroids will decrease time to shock reversal, alters the inflammatory cascade, and alters microcirculatory flow in post-cardiac arrest patients.


Eligibility criteria:
inclusion criteria: * greater than 18 years old * either pre-hospital cardiac arrest and rosc or inpatient cardiac arrest with resultant rosc * vasopressor dependent for a minimum of 1 hour post-arrest exclusion criteria: * pregnant * indication for corticosteroids outside of current research proposal * dnr or comfort care measures * presence of septic shock * chronic use (\>1week) of oral corticosteroids in the last year

Keywords: cardiac arrest, shock, steroids
treatment of initial caries lesions on proximal surfaces of primary and permanent posterior teeth

Conditions: Dental Caries; Compliance Behavior

Summary: this study aims to evaluate the effectiveness of 30% silver diamine fluoride in the treatment of clinically caries lesions in enamel, with radiographic image restricted to the enamel or the outer third of dentin on the proximal surfaces of primary and permanent posterior teeth. it also aims to compare it to the resin infiltration and to the control of proximal biofilm through the oral hygiene.

the sample will be comprised of 141 patients between 3 to 10 year-old and 504 proximal surfaces of 12-to-17-year-old adolescents, who present at least one proximal surface with initial caries lesion. patients will be randomly allocated to treatments, according to the technique to be employed: (i) resin infiltration (ii) 30% diamine silver fluoride, (iii) just daily flossing by the patient. all subjects will receive placebo treatments performed in other groups. the teeth will be evaluated by clinical and radiographic exams at baseline and after 1, 3, 6, 12, 18 and 24 months. in 1, 3 and 18 months will just be evaluated aspects related to the biofilm.

Eligibility criteria:
inclusion criteria: * primary teeth: distal surface of the first molar, mesial surface of the second molar and distal surface of the second molar (when the first permanent molar is present) with initial caries lesion (icdas 1, 2 or 3). * permanent teeth: distal surface of the first premolar, mesial surface of the second premolar, distal surface of the second premolar, mesial surface of the first molar, distal surface of the first molar and mesial surface of the second molar with initial caries lesion (icdas 1, 2 or 3). exclusion criteria: * mesial surface of the first primary molar/premolar by the smaller contact with the distal surface of the canines. it will be also excluded the surfaces that show proximal restorations, sealants, cavities, defects, as well as intact teeth.

Keywords: dental caries primary teeth permanent teeth silver diamine fluoride
the iset (isolation by size of epithelial tumor cells) and the cellsearch methods in malignant pleural mesothelioma

Conditions: Pleural Neoplasms; Mesothelioma; Pneumothorax; Parathyroid Neoplasms; Benign Tumor of the Thyroid; Tumor of the Thyroid

Summary: malignant pleural mesothelioma (mpm) has a growing incidence and in spite of early diagnostic, their outcome remains dismal. the evolution of mpm is often local with rare distant metastases. there is now a sizable body of evidence that metastases could develop from circulating tumor cells (ctc) spread in blood before or during surgery. thus, sensitive and specific detection of ctc in blood is considered as a potentially relevant predictive biomarker for patients with carcinomas. in exchange, the prognostic value of ctc in mpm has not yet been evaluated. indeed, the main goal for preoperative detection of ctc is to identify patients with high risk of recurrence after surgery, in order to perform more adapted therapeutic strategy. despite several studies reported about ctc detection, methodological aspects concerning sensitivity, specificity and reproducibility have prevented a clear appraisal of their clinical impact. thus, the aim of our study is to evaluate the presence and the prognostic value of ctc in mpm by a double approach. in our setting, cytopathological analysis of circulating non hematological cells (cnhc), of epithelial origin, isolated according to their size (iset, isolation by size of epithelial tumor cells) along with immunomagnetic selection, identification and enumeration of circulating epithelial cells in peripheral blood (cellsearch method) is considered a promising approach.


Eligibility criteria:
inclusion criteria for the patients: * age \> 18 years * patient having been operated for a strong suspicion of a pleural malignant tumoral lesion corresponding to a primitive pleural mesothelioma * signed patient consent for the control subjects: * age \> 18 years * unhurt of any malignant or mild tumoral pathology or patients that must benefit from a surgical procedure for a benign lesion in other organ than the pleura or a pulmonary non tumoral lesion * signed patient consent exclusion criteria : * patient with histories of cancer or the other synchronous cancer * patient with additives treatments * patient according to treatments additives others than protocols codified (in particular, platinum navelbine or gemcitabine platinum) for stages ii * hiv, hepatitis b or c infections * pregnant women

Keywords: [c08.785.640] (c08.528.778) [c19.642.713] mesothelium
implementation of a molecular diagnostic for pediatric acute gastroenteritis: the filmarray gi panel impact study

Conditions: Infectious Gastroenteritis

Summary: biofire diagnostics, llc (biofire) has developed the filmarray gastrointestinal (gi) panel, a rapid, easy to use pcr-based in vitro diagnostic test for the identification of 22 common microorganisms responsible for infectious gastroenteritis (http://filmarray.com/the-panels/) from a stool specimen collected in cary blair enteric transport media. the test was made available for sale in the us and eu following fda clearance and ce marking in may, 2014. the filmarray gi panel offers improvements over conventional laboratory testing which include: reduced turnaround time from specimen to result, reduced laboratory labor costs, increased sensitivity and specificity relative to current clinical reference methods, and larger breadth of organism identification than is available using standard methods. because of these attributes, the results from this test have the potential to enable clinicians to more accurately diagnose and treat gi illness in a reduced time frame. collaborators at the university of utah, brown university/lifespan, and biofire diagnostics have designed a study to evaluate health outcomes of pediatric subjects presenting to emergency departments with gi illness before and after establishing the filmarray gi panel as the standard of care method for stool pathogen analysis. it is hypothesized that the rapid (\~ 1 hour turnaround time), sensitive, specific, and comprehensive results provided by the filmarray gi panel will allow clinicians to more rapidly diagnose gi illness, initiate appropriate therapy and provide guidance when compared to the pre-implementation period.


Eligibility criteria:
inclusion criteria: * children (\<18 years) presenting to the ed or onsite urgent care center with symptoms of gastroenteritis (e.g. diarrhea, vomiting, nausea, etc.) * duration of symptoms at least 24 hours but \< 14 days * able to provide stool specimen at time of enrollment or within the next two calendar days * parent or guardian able to provide permission and subject able to provide assent, if appropriate exclusion criteria: * undefined onset of illness or symptoms for ≥14 days * unable to complete questionnaire or give informed consent because of language barrier * those unable to provide stool specimen at time of enrollment or within two calendar days * previous enrollment in this study

Keywords: multiplex polymerase chain reaction pcr biofire diagnostics infectious gastroenteritis diarrheal disease emergency department rapid diagnostics filmarray filmarray gi panel
clinic and neurophysiology of aphasia treatment

Conditions: Aphasia, Acquired

Summary: in the planned study, clinical and electrophysiological features of aphasia recovery in stroke patients are investigated.

clinical neurorehabilitation faces a major challenge of functional recovery in aphasia, i.e. guiding the structural and temporal dynamics of reorganization within responsible neural networks. here, according to current research, relevant neural factors affecting the treatment and thus the functional recovery of aphasia patients after stroke are of interest, highlighting structural as well as functional neuroanatomical features. of particular interest are not only the functional localization of affected cerebral regions, but more the clinical and neurophysiological patterns which might help to factorize and predict the therapeutic outcome. in the planned study, the clinical and neurophysiological characteristics of the dynamics of language function recovery in relation to the intensity of professional speech therapy (constraint induced aphasia therapie - ciat) will be recorded in 40 patients with aphasia resulting from a cerebrovascular event. the aim of this study is to test the value of neurophysiological aspects based on electroencephalographic (eeg) parameters such as event-related potentials (n400, p600, theta band activity) for the identification of specific neuronal markers, which in turn support predictive statements for individual therapy planning of logopedic treatment in neurorehabilitation.

Eligibility criteria:
inclusion criteria: * patients with a cerebrovascular event exclusion criteria: * premorbid brain disorder