Kornimate/medical-research-clean huggingface dataset:
tqb2928 injection combined anlotinib hydrochloride capsule in recurrent/metastatic osteosarcoma and other solid tumors

Conditions: Osteosarcoma; Other Solid Tumors

Summary: this is a multicenter, open-label, multi-cohort phase ib trial to evaluate the efficacy and safety of tqb2928 injection combined with anlotinib hydrochloride capsule in patients with relapsed/metastatic osteosarcoma and other relapsed/metastatic solid tumors.


Eligibility criteria:
inclusion criteria: * pathological diagnosis of high-grade osteosarcoma(cohort i),dedifferentiated liposarcoma or polytypic liposarcoma(cohort ii),unsuitable for local treatment; * the requirements for front-line treatment received by subjects are as follows: 1. subjects with osteosarcoma have failed at least first-line chemotherapy and are not suitable for re-receiving first-line chemotherapy ,or progression within 6 months of the end of first-line therapy; 2. subjects with dedifferentiated liposarcoma or polytype liposarcoma who have received at least first-line chemotherapy failure for recurrent/metastatic sites or relapse during postoperative adjuvant chemotherapy or within 6 months after treatment(considered first-line treatment failure). exclusion criteria: * history of hemolytic anemia from any cause (including evans syndrome) within 3 months prior to first dosing; * subjects with osteosarcoma or dedifferentiated liposarcoma/polytype liposarcoma who have previously used antiangiogenic tyrosine kinase inhibitors (tki) or bevacizumab or its biosimilar, such as anlotinib, apatinib, lenvatinib, sorafenib, sunitinib, regorafenib, fruquintinib; * previous antibody or fusion protein or small molecule drug targeting cd47 or signal-regulatory protein α (sirrp-α).
efficacy and safety of qurevo plus ribavirin based therapy for hepatitis c with or without cirrhosis in haemodialysis patients

Conditions: Chronic Hepatitis c

Summary: to evaluate efficacy and safety of ombitasvir, paritaprevir, and ritonavir plus ribavirin based therapy for chronic hepatitis c with or without compensated cirrhosis in haemodialysis patients.

the aim of this study is; to evaluate the efficacy and safety of ombitasvir, paritaprevir, and ritonavir based therapy for chronic hepatitis c with or without compensated cirrhosis in hcv treatment naïve patients receiving long-term haemodialysis through assessment of: 1. the proportion of patients with a sustained virological response (hcv rna \<25 iu/ml) 12 weeks after the last dose of study drug (svr12). 2. to determine withdrawal rate related to side effects and /or adverse effects for patients receiving at least 1 dose of the study medication.

Eligibility criteria:
inclusion criteria: 1. under regular hd for at least 6 months 2. clinically stable condition as outpatients. 3. treatment naïve patients with serum positive for hcv gt4 with hcv rna \> 1000 iu/ml by pcr. 4. white blood cell count \> 2500/mm\^3. 5. platelet count \> 7500/mm\^3. 6. patients categorised as having compensated cirrhosis had a diagnosis of cirrhosis based on a previous screening liver fibrotest score of 0·72 or lower (eg, metavir fibrosis score \>3 \[including 3/4 or 3-4\] ). exclusion criteria: 1. confirmed pregnancy. 2. hcv-hiv co infection. 3. hbv-hcv co infection. 4. uncontrolled hyper or hypothyroidism. 5. for patients without cirrhosis, patients will be excluded if alanine or aspartate aminotransferase more than five times the upper limit of normal, for patients with cirrhosis they will be excluded if alanine or aspartate aminotransferase are higher than seven times the upper limit of normal 6. patients on peritoneal dialysis.
impact of pleural manometry on chest discomfort after therapeutic thoracentesis

Conditions: Pleural Effusion

Summary: this randomized controlled trial attempts to determine whether the measurement of pleural pressures during therapeutic thoracentesis affects the development of chest discomfort after the procedure. during thoracentesis, pleural fluid is drained from the pleural space, resulting in lung expansion. in some cases, the lung is not completely re-expandable, in which case continued drainage results in the development of negative pleural pressures and chest discomfort. negative pleural pressures may also result in other complications such as re-expansion pulmonary edema and pneumothorax. the identification of negative pleural pressures via manometry during the procedure may lead to a reduction in the complication rate.

primary objectives: i. to study the impact of pleural manometry on the development of chest discomfort during therapeutic thoracentesis compared to conventional symptom-guided thoracentesis. outline: patients are randomized to 1 of 2 treatment arms. arm i: patients undergo manometry-guided therapeutic thoracentesis. arm ii: patients undergo symptom-guided thoracentesis.

Eligibility criteria:
inclusion criteria: * referral to pulmonary or interventional radiology services for large-volume thoracentesis * presence of a symptomatic moderate or large free-flowing pleural effusion on the basis of: * chest radiograph: effusion filling \>= 1/3 the hemithorax, or * computed tomography (ct)-scan: maximum anteroposterior (ap) depth of the effusion \>= 1/3 of the ap dimension on the axial image superior to the hemidiaphragm, including atelectatic lung completely surrounded by effusion, or * ultrasound: effusion spanning at least three rib spaces with depth of \>= 3 cm exclusion criteria: * inability to provide informed consent * study subject has any disease or condition that interferes with safe completion of the study including: * coagulopathy, with criteria left at the discretion of the operator * hemodynamic instability with systolic blood pressure \ 120 beats/min, unless deemed to be stable with these values by the attending physicians * pleural effusion is smaller than expected on bedside pre-procedure ultrasound * referral is for diagnostic thoracentesis only * manometry felt to be clinically indicated * inability to assume or maintain a seated position for the procedure * presence of multiple loculations on bedside pre-procedure ultrasound
structural heat adaptation and education in rural setting

Conditions: Heat Illness

Summary: this study aims to understand whether simple, low-cost interventions, such as improved home cooling, practical advice, and minor home modifications, can help protect people's health during periods of extreme heat in rural, low-income villages of matiari, pakistan. key questions the study seeks to answer: 1. can these interventions reduce heat-related health problems such as dizziness, headaches, and heatstroke? 2. can they lower indoor temperatures and improve sleep quality, comfort, and daily functioning? to answer these questions, researchers will compare communities where families receive heat-related support and information with similar communities that do not, to assess any differences in health and well-being. what participants can expect: * answer questions about their health, living conditions, and how they cope with heat * have small temperature sensors placed inside their homes * some participants may wear a lightweight wristband that tracks sleep and heart rate * in selected households, cooling improvements will be made, such as adding shade, applying reflective roof paint, or enhancing airflow purpose: this study seeks to identify affordable and effective strategies to help families stay safe during extreme heat, and to use these insights to support other vulnerable communities facing similar challenges.


Eligibility criteria:
inclusion criteria: * all households within the selected clusters who provide consent. exclusion criteria: * households planning to move away from the study site within the next 6 months * individuals with severe mental or physical health conditions that preclude participation

Keywords: heat illness behaviour modification personal cooling structural modification heat adaptation prevention rural
evaluation of decisional conflict and needs assessment in asthma management

Conditions: Asthma

Summary: many patients suffering from asthma are not compliant to their treatment and consequently, are not well controlled. shared decision making intervention has shown an improvement in the outcome of patients with chronic disease. the aim of this study is to evaluate decisional conflict and to assess decisional needs of adults with asthma.

asthmatic patients will be recruited and asked to fill a decisional conflict scale. patients, asthma educators and physicians will also be recruited to fill a needs assessment questionnaire about decisions taken by asthmatics.

Eligibility criteria:
inclusion criteria: * 18-65 years * diagnosed asthma exclusion criteria: * received asthma education in the past 2 years
preoperative tamsulosin to prevent postoperative urinary retention after surgery for pelvic floor disorders

Conditions: Urinary Retention

Summary: our hypothesis is that patients receiving preoperative tamsulosin will have decrease rates of postoperative urinary retention (pour) after surgery in females for pelvic floor disorders.

this study is a prospective randomized control trial. patients undergoing pelvic surgery will randomized into two groups. the study group will receive one oral dose of .4mg of tamsulosin preoperatively.the control group will receive one placebo pill preoperatively. success or failure of initial voiding trial in postoperative period will be measured. patients who fail the voiding trial will be discharged home with foley catheter as is standard protocol at our institution.

Eligibility criteria:
inclusion criteria: i. patient undergoing surgery for prolapse with or without mid-urethral sling procedure. ii. specific surgical procedures include all vaginal, laparoscopic and robotic reconstructive or obliterative surgeries including the use of mid-urethral slings exclusion criteria: i. diagnosis of urinary retention preoperatively (post void residual \>150ml) ii. malignancy iii. history of neurological disease iv. history of spinal cord injuries v. allergy to tamsulosin vi. perioperative complications requiring prolonged postoperative bladder drainage vii. incontinence procedures other than mid-urethral slings

Keywords: female pelvic floor disorders postoperative urinary retention tamsulosin
atrial fibrillation registry in jordan

Conditions: Atrial Fibrillation

Summary: prospective registry of all new comers with atrial fibrillation

12 tertiary care centers will enroll all af comers. details of baseline clinical, ekg, echo, and lab data will be documented for all patients. management is according to the physicians discretion. patients will be followed up for 1 year for clinical endpoints including cardiovascular death, stroke, heart failure, systemic embolization and bleeding.. anticoagulants and other cardiovascular medications will also be documented.

Eligibility criteria:
inclusion criteria: * admission with atrial fibrillation * developing atrial fibrillation during hospitalization for mon af reason. * age 18 or more years. * patients welling to participate in the registry. exclusion criteria: * age less than 18 years. * patients not welling to participate.

Keywords: atrial fibrillation registry middle east jordan risk factors in hospital management long term management
effectiveness of physical therapy treatments of myofascial trigger points in subjects with neck pain

Conditions: Neck Pain; Myofascial Pain Syndrome

Summary: neck pain is a prevalent musculoskeletal dysfunction. studies point that individuals with chronic pain have metabolic, vascular and electromyographic changes in trapezius muscle. moreover, a common clinical sign in this muscle in subjects with neck pain is the presence of myofascial trigger points. these are related to the sensory, motor and autonomic changes, being defined as palpable nodules located in the taut band of skeletal muscle. in this context, the focus on treatment modalities stands out in the literature, however, other resources commonly used in clinical practice still lack scientific evidence. therefore, the aim of this project is to evaluate the effectiveness of physiotherapy resources in the treatment of myofascial trigger points in the trapezius muscle of patients with neck pain. for such, volunteers with neck pain for more than 90 days, of both genders, aged between 18 and 59 years and bilateral myofascial trigger points in the upper trapezius will be randomized into the following groups: group 1 (kinesiotherapy, n = 20), group 2 (kinesiotherapy + static ultrasound, n = 20), group 3 (kinesiotherapy + diadynamic currents, n = 20) and group 4 (untreated control, n = 20). volunteers will undergo ten sessions of treatment, being realized the following evaluations: surface electromyography, infrared thermography, numerical scale of pain assessment, algometry, neck disability index and skin impedance. for data analysis, normality test will used to verify the data distribution and consistent statistical test for the appropriate comparisons within and between groups, and thus considered two factors in the comparisons, time and group. will adopt a significance level of 5%.


Eligibility criteria:
inclusion criteria: * neck pain for more than 90 days * aged 18 to 59 years * presence of trigger points in the upper trapezius muscle exclusion criteria: * history of trauma to the neck * surgery in the head, face or neck * herniated cervical * degenerative diseases of the spine * systemic diseases * underwent physical therapy in the last three months * analgesics, anti-inflammatories or muscle relaxants last week * medical diagnosis of fibromyalgia * body mass index (bmi) greater than 28 kg/m2 * signs and symptoms of depression

Keywords: physical therapy modalities myofascial pain syndromes skeletal muscle
drug use investigation of kovaltry in hemophilia a patients

Conditions: Hemophilia A

Summary: the objective in this study is collecting post-marketing information on the safety and efficacy of kovaltry under the routine clinical practice.

this company-sponsored study is a single-arm, prospective, observational study in hemophilia a patients administered kovaltry. 200 cases will be planned to be registered as safety analysis set in three-year period. within 200 cases, 50 cases less than 12 years old will be planned to be registered. target population are all hemophilia a patients. the treatment should be performed based on the product label in japan. the standard observation period is two years.

Eligibility criteria:
inclusion criteria: * male and female hemophilia a patients. * patients for whom the decision to treat with kovaltry was determined prior to enrollment in the study. exclusion criteria: * patients participating in an investigational program with interventions outside of routine clinical practice. * patients with an additional diagnosis of any bleeding/coagulation disorder other than hemophilia a

Keywords: kovaltry hemophilia a japan post-marketing surveillance
phase ii of lenvatinib plus toripalimab for advanced hcc

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to evaluate the efficacy and safety of lenvatinib combined with toripalimab in patients with advanced hepatocellular carcinoma (hcc)

lenvatinib was non-inferior to sorafenib in overall survival in untreated advanced hepatocellular carcinoma. no study has evaluated the efficacy and safety of lenvatinib plus toripalimab. thus, the investigators carried out this single-arm, prospective, phase ii study to find out it.

Eligibility criteria:
inclusion criteria: * the diagnosis of hcc was based on the diagnostic criteria for hcc used by the european association for the study of the liver (easl) * patients must have at least one tumor lesion that can be accurately measured according to easl criteria. * barcelona clinic liver cancer-stage c * eastern cooperative oncology group performance status of 0 to 2 * with no previous systemic treatment * no cirrhosis or cirrhotic status of child-pugh class a only * not amendable to surgical resection ,local ablative therapy and any other cured treatment. * the following laboratory parameters: platelet count ≥ 75,000/μl hemoglobin ≥ 8.5 g/dl total bilirubin ≤ 30mmol/l serum albumin ≥ 30 g/l asl and ast ≤ 5 x upper limit of normal serum creatinine ≤ 1.5 x upper limit of normal inr ≤ 1.5 or pt/aptt within normal limits absolute neutrophil count (anc) \>1,500/mm3 ability to understand the protocol and to agree to and sign a written informed consent document exclusion criteria: * evidence of hepatic decompensation including ascites, gastrointestinal bleeding or hepatic encephalopathy * known history of hiv * history of organ allograft * known or suspected allergy to the investigational agents or any agent given in association with this trial. * cardiac ventricular arrhythmias requiring anti-arrhythmic therapy * evidence of bleeding diathesis. * patients with clinically significant gastrointestinal bleeding within 30 days prior to study entry. * known central nervous system tumors including metastatic brain disease

Keywords: hepatocellular carcinoma lenvatinib toripalimab
real life automatic atrial capture device control

Conditions: Sinus Bradycardia; Sinus Node Disease; Atrio-ventricular Block; Heart Failure

Summary: the main objective of this study is to verify the effectiveness of the new acap ® confirm algorithm in the automatic management of atrial capture.


Eligibility criteria:
inclusion criteria: * patients had undergone first implantation or device replacement with a medical device (pm, icd, crt-p, crt-d) endowed with acap confirm ® algorithm features between may 2011 and march 2012 exclusion criteria: * atrial fibrillation

Keywords: acap, automatic algorithm
aerobic exercise for cognition in schizophrenia

Conditions: Schizophrenia

Summary: this study will evaluate the ability of aerobic exercise (ae) to improve cognition in people with schizophrenia. participants will be randomly assigned to one of two interventions: (1) aerobic exercise class (stationary bicycle, or "spin" class) for up to 45 minutes three times per week for 12 weeks, or (2) balance and stretching class for up to 45 minutes three times per week for 12 weeks.

schizophrenia (scz) is a severe, chronic, and disabling psychotic illness that affects approximately 87,000 veterans. previous studies have reported improved short-term memory with ae, but there in a lack of information on cognitive effects of ae in scz. the investigators want to determine if twelve weeks of ae training improves cognitive function in veterans with scz.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia or schizoaffective disorder * maintained on stable doses of outpatient psychiatric medications for at least 30 days * compliant with outpatient follow-up * have a stable place to live * access to transportation to the hospital * doing less than 20 minutes per week of regular physical activity in the past month exclusion criteria: * bipolar disorder; * active substance dependence within the prior 30 days * more than 2 psychiatric admissions within the prior six months * known hiv infection or aids * history of traumatic brain injury * current seizure disorder * alzheimer's disease or other dementia * clinical history of mild cognitive impairment * parkinson's disease * other current clinically significant neurological disease * unstable medical condition that would be expected to interfere with fitness training * significant hearing or visual impairment

Keywords: schizophrenia exercise cognition
an intravenous iron based protocol for preoperative anaemia in hip and knee surgery - an observational study

Conditions: Anemia; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee

Summary: this observational study follows a cohort of patients scheduled for elective hip- or knee surgery but has preoperative anemia and are treated with intravenous (iv) iron prior to surgery according to a recently introduced standardized treatment protocol at 6 high-volume surgical centres.

patients presenting with preoperative anaemia prior to hip and knee arthroplasty has a high risk of receiving allogeneic blood transfusion and anaemia has been associated with increased postoperative morbidity and mortality. while iv-iron administration may raise hb prior to surgery, existing guidelines for addressing and treating preoperative anaemia is not widely implemented for patients scheduled for elective total joint arthroplasty (tja) in denmark. in addition, causes of preoperative anaemia and the efficacy of preoperative iv-iron administration has not been sufficiently evaluated in elective tja. this is a observational follow-up study among 6 danish high volume surgical centres that has recently introduced a standardized anaemia screening and treatment protocol for patients with preoperative anaemia scheduled for total hip- or knee arthroplasty. patients with iron deficiency anaemia or anaemia of chronic inflammation receive infusion of iv-iron (monofer) 4 weeks prior to surgery as a part of the standard operating procedure on the department. the aim of this follow up study is to evaluate changes in haemoglobin concentration, transfusion rate and postoperative morbidity in this cohort.

Eligibility criteria:
inclusion criteria: * age \> 18 years * scheduled for elective primary hip- or knee arthroplasty * preoperative hemoglobin \< 13 g/dl (males) or \< 12 g/dl (females) * included in the departments treatment protocol for preoperative anemia exclusion criteria: * cronic transfusion need * not able to give consent

Keywords: patient blood management preoperative anemia iv iron
black and african americans connections to parkinson's disease (blaac pd)

Conditions: Parkinson Disease

Summary: blaac pd is a research study to understand what parkinson's disease looks like for black and african american communities. blaac pd is happening at research centers around the united states. the study is part of the global parkinson's genetics program (gp2). gp2 is a research project working to transform understanding of the genetics of parkinson's disease and make that knowledge globally relevant.

research studies have found connections between genes and parkinson's disease (pd). but those results have mostly come from studies with non-black or african american volunteers. blaac pd aims to learn more about gene changes that may cause parkinson's in black and african american people. study volunteers at sites across the united states will attend one visit and will give either a blood or saliva sample, complete a smell test, and may be asked to complete a physical exam. this new data could lead to future parkinson's tests and treatments for black and african american people and it may help better understand disease in other groups, too. this pioneering initiative will fill a gap of knowledge about pd in black and african american people.

Eligibility criteria:
inclusion criteria for control participants: * ability to provide informed consent * age 18 years or older * self-identify as black or african american exclusion criteria for control participants: * diagnosis of parkinson's disease and/or neurological condition * familial history of pd and/or neurodegenerative or psychiatric conditions * unknown family history of pd and/or neurodegenerative or psychiatric conditions * any conditions that, in the investigator's opinion, preclude the individual's ability to carry out study activities * if submitting a saliva sample, nothing by mouth (food, drink, gum, tobacco, or smoking) for 30 minutes prior to sample collection inclusion criteria for participants with a diagnosis of pd: * ability to provide informed consent * age 18 years or older * self-identify as black or african american * meet the movement disorder society's clinical diagnostic criteria for parkinson's disease exclusion criteria for participants with a diagnosis of pd: - if submitting a saliva sample, nothing by mouth (food, drink, gum, tobacco, or smoking) for 30 minutes prior to sample collection

Keywords: genetics racial health disparities