Kornimate/medical-research-clean huggingface dataset:
finite element study of biomechanical changes after unilateral hemilamina and facet joint resection of cervical spine

Conditions: Intraspinal Tumor

Summary: finite element method was used to simulate unilateral hemilaminectomy of cervical spine and facet joint resection of different degrees, and the range of motion and the stress changes of ligament, intervertebral disc and endplate were calculated immediately after operation

the finite element method was used to simulate unilateral hemilaminectomy of cervical spine and different degrees of facet joint resection, and the range of motion and the stress changes of ligaments, intervertebral discs and endplates were calculated immediately after the operation. finite element method was used to simulate unilateral hemilaminectomy of cervical spine and facet joint resection of different degrees, and the range of motion and the stress changes of ligament, intervertebral disc and endplate were calculated immediately after operation. study design: this study is a retrospective and general observational study.in this study, a young patient who was hospitalized in the neurosurgery department of the third hospital of beijing university of medicine and had undergone ct examination of cervical vertebra was selected. the patient had no cervical bony deformity, no cervical degeneration, and no history of trauma. ct imaging data were collected, and a three-dimensional finite element model of c2-t1 segment of human cervical spine was established by finite element software. on the basis of this model, two and three levels of unilateral hemilamina and different degrees of facet joint resection were simulated.the lower end of the t1 vertebral body was fixed as the boundary condition, and three loading modes were adopted, namely, 2.0nm pure torque was applied to the upper surface of the c2 vertebral body along the sagittal plane, coronal plane and axial plane, respectively.the range of motion between vertebral segments was calculated and compared in different lamina surgical models. the tension of ligaments, the pressure of endplates and the pressure of intervertebral discs were obtained by finite element post-processing

Eligibility criteria:
inclusion criteria: a young patient hospitalized in the department of neurosurgery of the third hospital of beijing university of medicine underwent ct examination of cervical vertebrae. exclusion criteria: cervical bony deformity cervical degeneration history of trauma
impact of dietary counseling on efficacy of tooth bleaching

Conditions: Tooth Discoloration

Summary: the aim of this study will be to evaluate if subjects submitted to a white diet counseling during home dental bleaching will present better results than subjects that maintained their usual diets. forty patients will be divided into two groups and randomly allocated to each group: usual diet (control) or white diet, avoiding dye-containing food and beverages. patients will be assessed through a food frequency questionnaire and color measurement using a spectrophotometer at baseline and six months after bleaching.


Eligibility criteria:
inclusion criteria: * adults, aged 18 or higher; * central incisors with shade a2 or darker exclusion criteria: * undergone previous dental bleaching procedures; * under orthodontic treatment; * pregnant or lactating women.
influence of artificial tears on keratometry and biometry measurements with different devices

Conditions: Healthy

Summary: the goal of this clinical trial is to learn about the influence of artificial tears on measurements of healthy eyes with three different devices. the main questions it aims to answer are: * do artificial tears alter the measurements of the corneal surface * is there a difference between the devices used in this study this is relevant because high quality measurements improve the postoperative outcome after cataract surgery.


Eligibility criteria:
inclusion criteria: * healthy eyes exclusion criteria: * any prior intraocular surgery or trauma * any corneal pathology (abmd, fuch's, etc.) * active ocular pathology (e.g., amblyopia, armd) * contact lens wear within 2 weeks of study * any corneal relaxing incisions or astigmatic keratotomy

Keywords: artificial tears keratometry topography
association of passiflora incarnata l; crataegus oxyacantha l and salix alba l. on mild and moderate anxiety

Conditions: Anxiety Disorder

Summary: phase iii, multicentric, double blind, randomized study, controlled by valeriana officinalis for evaluating the efficacy of association of passiflora incarnata l; crataegus oxyacantha l and salix alba l. on mild and moderate anxiety. the treatment period will last 6 weeks and be followed by a post treatment visit. hamilton anxiety scale will be used to assess anxiety.

passiflora incarnata l; crataegus oxyacantha l are plant-derived treatment widely used to treat anxiety disorders. this study will compare the association of passiflora incarnata l; crataegus oxyacantha l and salix alba l for the treatment of mild and moderate anxiety. 150 participants will be randomly assigned to receive the association of passiflora incarnata l; crataegus oxyacantha l and salix alba l. or valeriana officinalis for 6 weeks. a post treatment visit will be done 2 weeks for safety evaluation. primary outcome: hamilton anxiety (ham-a) scale secondary outcome: insomnia quality index, global clinical impression and patients global evaluation scales. side effects will be monitorized throughout the study.

Eligibility criteria:
inclusion criteria: * generalized anxiety disorder * ham-a scale \ 30 exclusion criteria: * hypersensibility to any component * patients with depression, schizophrenia ou suicidal ideas * pregnant ou lactating * heart, liver, lung or kidney important condition * use of digitalis, aas, anticoagulants agents, drugs with sedative or antidepressant action * psychotherapy * drug or alcohol dependence * gastrointestinal ulcer history * hyperthyroidism * neoplasia * coagulation disorders

Keywords: passiflora crataegus herbal valeriana anxiety
reducing duration of untreated psychosis through rapid identification and engagement

Conditions: Psychotic Disorders

Summary: reducing duration of untreated psychosis (dup) is a primary goal for improving long-term outcomes in young people with a first episode of psychosis (fep). the "standard of fep care" within the us focuses on targeted provider education regarding signs and symptoms of early psychosis to motivate patient referrals to fep services, followed by initiation of services within largely clinic-based settings experience at the early diagnosis and preventive treatment (edapt) fep specialty program at u.c. davis in sacramento has identified two important bottlenecks to reducing dup, consistent with reports in the literature from other fep clinics. these are 1) delays in the identification of psychotic symptoms by referral sources, and 2) delays or disruptions of patient engagement in specialty fep care. building upon a comprehensive and established referral network of 20 sites across the sacramento area (schools/universities, er/inpatient hospitals, outpatient mental health, primary care), the investigators will address delays in patient identification and engagement using a two-phase, cluster randomized design. the investigators will consecutively test the impact of two interventions to reduce dup, defined in this rfa as time from first onset of psychotic symptoms to engagement in fep specialty care. to address identification delays, the investigators will examine the use of standard targeted provider education plus novel technology-enhanced screening compared to standard targeted provider education alone, testing the hypothesis that the education plus technology-enhanced screening will identify more patients, earlier in their illness. to address engagement delays, the investigators will compare the use of a mobile community-based, telepsychiatry-enhanced engagement team to standard clinic-based procedures for intake, engagement and initiation of treatment, to test the hypothesis that the mobile approach facilitates earlier and more stable engagement, thereby reducing dup. the proposed work will provide new specific evidence-based practices for reducing dup and improving outcomes through specialty care of individuals with a first episode of psychosis.


Eligibility criteria:
inclusion criteria: meet dsm-iv criteria for a diagnosis of affective or nonaffective psychosis. exclusion criteria: 1. duration of psychosis \> 2 years 2. current substance dependence 3. neurological illness or injury leading to psychotic symptoms 4. only substance induced psychotic symptoms 5. documented iq \< 70 6. lack of english fluency
non-invasive caries management: clinical study

Conditions: Caries,Dental; Caries Arrested

Summary: clinical trial to compare non-invasive and minimally-invasive therapies on the progression of the caries lesions. clinical investigation of resin infiltration versus sodium fluoride (5% naf) varnish application.

dental caries is the most globally prevalent disease that affects thousands of adults and children. caries is a biofilm-mediated, sugar-driven, multifactorial, and dynamic disease that results from the imbalance between demineralization and remineralization of the dental hard tissues. preventing the onset of the disease should be the primary goal; however, once the disease is present efforts should be made by both patient and clinician to successfully reestablish the mineralization balance by the use of preventive and/or minimally-invasive methods when possible. the sodium fluoride (5% naf) varnish is one of the most common therapies used as a non-invasive approach for caries prevention and remineralization; and, the resin infiltration materials are indicated for the minimal intervention of non-cavitated occlusal and proximal caries. the minimal intervention has been considered the new concept of caries management. although several studies discussing minimal intervention or non-intervention are available, there is a lack of published randomized controlled trials (rcts) providing data about the use of non-invasive therapies on incipient lesions, and its correlation with the patient's caries risk. the aim of this study is to evaluate the efficacy non-invasive and minimally-invasive therapies on the progression of the caries lesions considering the patient's caries risk. this study will be conducted in the province of ontario, canada. a total of thirty patients (15 to 50 years old), who present with a minimum of two incipient proximal carious lesions on the proximal surfaces of posterior teeth (non-cavitated lesions identified as small, faint radiolucent areas seen on the intra-oral radiographs) will be asked to participate in this study. the radiologic assessment of incipient lesions will be performed by a dental radiologist, blinded to the selected treatment groups, by comparison of the radiographs imaging over time.

Eligibility criteria:
inclusion criteria: * patients must present at least two non-cavitated proximal caries lesions * patients must be able to give informed consent in english * patients must be resident in london, ontario, or nearby locales with community fluoridation exclusion criteria: * patients presenting proximal caries that are beyond the outer third of dentin * patients suffering from a disability that impairs dental hygiene performance * patients that are unable to perform her/his own oral hygiene
intratympanic administration of n-acetylcysteine for protection of cisplatin-induced ototoxicity

Conditions: Ototoxic Hearing Loss; Ototoxic Hearing Loss, Bilateral; Ototoxicity; Tinnitus

Summary: the purpose of this study is to assess the efficacity of n-acetylcystein against cisplatin-induced ototoxicity.

this is a monocentric, randomized, controlled, open label phase iv superiority trial. after signing the informed consent form and upon the confirmation of the patient eligibility, patients will be randomized 1:1 to the experimental arm (nac + cisplatin) or the standard arm (cisplatin). the primary objective of this trial is to evaluate the protecting effect of lysomucil® 10% against cisplatin-induced ototoxicity. in this case, we will evaluate its effect through the transtympanic administration in both ears.

Eligibility criteria:
inclusion criteria: * ≥ 18-year-old * patients suffering from a neoplastic disease for which treatment protocol includes cisplatin. exclusion criteria: * women of childbearing potential pregnant or with intention to become pregnant within the trial duration * women who are breastfeeding * pathological findings on otoscopy that do not allow safe intratympanic drug delivery. * conductive hearing loss \> 20dbhl * meniere disease * medical history of sudden hearing loss * sensoryneural hearing loss (snhl) with mean ≥ 40dbhl pure tonal audiometry (pta)
studies examining the importance of smoking after being diagnosed with lung cancer

Conditions: Lung Cancer

Summary: a large project consisting of: a) an observational trial where smoking status is recorded on 1400 consecutive people newly diagnosed with lung cancer. smoking status is biologically validated with exhaled carbon monoxide (eco) levels every 3 months. survival, cancer progression and treatment complications will be recorded and compared in smokers, ex-smokers and never smokers.

smoking causes around 85% of lung cancer. continued smoking after diagnosis probably worsens survival and increases treatment complications but prospective well-designed studies are lacking. this project is an observational cohort study recording outcomes in smokers, never-smokers, and ex-smokers, using exhaled carbon monoxide to validate smoking status when they attend for further lung cancer clinics. this project is unique, as every patient with a clinical diagnosis of lung cancer will have their smoking status biologically validated by a quick and easy test, and those enrolled in the smoking cessation treatments or not will also complete a generic quality of life questionnaire at regular intervals. these appointments will coincide with other hospital appointments wherever possible, and survival status will reported up to 24 months after enrolment.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of lung cancer exclusion criteria: * refusal consent * inability to provide exhaled co * active psychiatric illness or substance misuse * concurrent malignancies of another type other than non-melanoma skin cancer * unable to travel for sessions with smoking cessation counsellor and / or outpatient visits from outset * who performance status 4 * life expectancy less than 6 weeks.

Keywords: smoking cessation mortality quality of life
ibuprofen suppositories administration in infants and children

Conditions: Fever

Summary: the study will evaluate the efficacy of ibuprofen administered as suppositories in the treatment of fever in infants and children. ibuprofen as suppositories is not yet registered in israel, although widely used in europe.

the drug will be used in 100 consecutive infants and children admitted with fever at the pediatric er of the soroka medical center. the information on the drug efficacy will be collected in appropriate parental questionnaires.

Eligibility criteria:
inclusion criteria: * infants and children with rectal temperature \> 38.5 c exclusion criteria: * infants \< 6 months of age

Keywords: ibuprofen children fever
mindfulness breath awareness meditation and preeclampsia

Conditions: Mindfulness Breath Awareness Meditation; Preeclampsia

Summary: the effect of mindfulness breath awareness meditation on health profile, vital signs, and fetal heart rate in pregnant women with preeclampsia

the aim of this study is to determine the effect of mindfulness breath awareness meditation (mbam) on health profile, vital signs, and fetal heart rate in pregnant women with preeclampsia. sample size: * there will be two groups in the study. * experiment group is breath awareness meditation group. * the sample size of the study is 66 women. * the sample size will be divided into two and 33 women will be randomly assigned to each group. application time: * the application will be started after the pregnant women diagnosed with pre-eclampsia is admitted to the perinatology service. * it will be applied total nine times in once every eight hours during the 72 hours that the pregnant women diagnosed with 20 minutes. * only mindfulness breath awareness meditation (mbam) will not be applied to the control group. care and follow-up will be performed in parallel with the individuals in the experimental group. data collection tools: * descriptive information form * nottingham health profile scale measurement time: * pregnant women will fill in the introductory information form before the first application. * each session of mindfulness breath awareness meditation practice will 20 minutes. * pregnant women will fill the nottingham health profile scale before the first application. it will then be refilled at the same time every 24 hours for 72 hours. the nottingham health profile will be completed a total of four times. * vital signs (systolic and diastolic blood pressure, body temperature, pulse, respiration, oxygen saturation) will be measured immediately before the first application. they will then be refilled at the same time every 24 hours for 72 hours. vital signs will be completed a total of four times. * fetal heart rate and fetal movement count will be measured immediately before the first application. they will then be refilled at the same time every 24 hours for 72 hours. fetal heart rate and fetal movement count will be assessed by non-stress testing (nst). the pregnant woman will undergo nst for 20 minutes.

Eligibility criteria:
inclusion criteria: * pregnant women who is admitted to the perinatology service of the hospital with the diagnosis of preeclampsia, * who is 19 to 49 years old, * who is 20 and over weeks of gestation, * who followes by at least three days of hospitalization in the ward. exclusion criteria: * pregnant women who do not meet the inclusion criteria and who voluntarily withdraw at any stage after inclusion will be excluded from the study.

Keywords: mindfulness breath awareness meditation preeclampsia pregnant women health profile vital signs fetal heart rate
establishment and standardization of a platform for in-depth tumour profiling (tupro) in patients with melanoma

Conditions: Melanoma

Summary: tupro-melanoma is the first project of the tumour profiler (tupro) research collaboration, which in the long-term aims to generate data that will help to understand and report the individual tumour biology and the clinical parameters for patients with advanced malignancies using innovative molecular technologies and computational analyses for in-depth molecular profiling. tupro-melanoma is an exploratory project that aims to establish a comprehensive platform for in-depth tumour profiling in patients suffering from advanced melanoma. aims of this platform are to establish logistics and algorithms for integrative analyses and discover new molecular biomarker profiles/patterns.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * ecog performance status ≤2 (not bedridden for more than 50% of waking hours) * stage iii or iv cutaneous melanoma, or rare melanoma subtypes at any stage that require systemic therapy * written informed consent according to national legal and regulatory requirements prior to any project specific procedures exclusion criteria: * any other serious underlying medical, psychiatric, psychological, familial or geographical condition, which in the judgment of the sponsor-project leader or site project leader may interfere with the project or affect patient compliance * legal incompetence
• sleep disturbance among patients with psoriasis and atopy and comparison between them

Conditions: Sleep Disturbance

Summary: comparison between sleep disturbance in atopy and psoriasis and control

sleep is essential for daytime functioning and health and important for both psychological and physiological wellbeing . a growing body of research indicates that chronic sleep disturbance is associated with impaired quality of life (qol) and a risk factor for poorer health, for example depression cardiovascular disease, hypertension 1 and diabetes. insomnia, the most common sleep disorder, is a clinical condition defined as difficulties falling asleep and/or maintaining sleep and/or poor sleep quality despite adequate opportunity for sleep resulting in significant daytime impairment. the development of insomnia in healthy populations has a bi-directional relationship with psychological factors such as anxiety, depressive symptoms and stress, and may in clinical populations also be associated with physical symptoms, such as pain. the physical symptoms in psoriasis, such as itch, one would expect a higher prevalence of sleep disturbance in this patient group. on the other hand sleep disturbance is common also in patients with atopic dermatitis (ad). patients with ad often have sleep disturbances due to pruritus.

Eligibility criteria:
inclusion criteria: - patients with psoriasis and patients with a topic dermatitis exclusion criteria: * all patient have another dermatological disease
evaluation of the perception of quality of care of patients admitted to a medical-surgical icu

Conditions: Critically Ill

Summary: the objective of this prospective observational cohort study is to describe the perception of quality of care of patients or reference companions admitted to a medical-surgical icu.

background: quality assessment in health systems is essential for the improvement and development of services. assessments using the structure, process and outcomes model are the most widespread, however understanding the health system as a business model makes assessment essential. how much the service is able to meet the expectations of the patient and the market. the institute for healthcare improvement (ihi) highlights three domains (triple aim) in which health systems must develop. among them is "improving the patient experience". one of the 6 domains of quality of care is patient-centeredness. several funding institutions and scientific authorities have, in recent years, encouraged patient-centered clinical research with the use of outcomes that are also patient-centered. the perception of the quality of the service provided to the critically ill patient or even is an uncommon outcome in the literature, especially evaluated with an objective and effective tool. the servqual tool proposed by parasuraman et al. it aims to compare the expectations and perceptions of the patient/companion regarding the quality of care provided. in the literature, data on patient-centered perspectives and demands are scarce. purpose: to identify the difference between expectation and perception of care quality during the stay in the general icu of a tertiary hospital. objectives: to evaluate the perception of quality of care of patients admitted to a general icu through the servqual tool translated and culturally adapted to the portuguese idiom. methods: a prospective, observational cohort study involving adult patients admitted to the general icu (53 beds) of a tertiary hospital from july 1 to september 30, 2023. the servqual tool questionnaire of expectations will be applied in the first 24 hours after admission to the icu and the perception questionnaire applied in the first 24 hours after discharge from the unit.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years old * consent form signed by the patient or a family member. exclusion criteria: * patients unable to respond and who do not have reference companions * patients readmitted to the icu during the study period.

Keywords: critically ill patients servqual tool quality of care expectations perceptions