Kornimate/medical-research-clean huggingface dataset:
a research study to evaluate the effects of repeated intravitreal injections on bacteria around the eye

Conditions: Central Retinal Vein Occlusion; Choroidal Neovascularization; Age-related Macular Degeneration; Branch Retinal Vein Occlusion

Summary: this is a research study to evaluate the effects of repeated intravitreal injections on bacteria around the eye.

the primary objective of this study is to determine whether conjunctival bacterial flora are altered and/or demonstrate increasing antibiotic resistance after serial intravitreal injections when a prophylactic topical antibiotic is used pre- and post-injection compared to when they are not used.

Eligibility criteria:
inclusion criteria: subjects will be eligible if the following criteria are met: * ability to provide written informed consent and comply with study assessments for the full duration of the study. * have been diagnosed with neovascular amd, crvo or brvo. * have been determined by the investigator to require intravitreal injections of bevacizumab or ranibizumab. exclusion criteria: subjects meeting any of the following criteria are ineligible for study entry: * prior intraocular injection in either eye. * chronic use of opthalmic medication. * contact lens wear. * ocular surgery within the past 6 months. * use of ophthalmic medications in either eye or ocular infection within the past 6 months. * use of systemic antibiotics within 6 months. * known allergy or contraindication to povidone iodine or fluoroquinolones.

Keywords: conjunctival bacterial flora prophylactic topical antibiotic injection intravitreal injection bacterial resistance serial injection serial intravitreal injections cnv crvo amd brvo
study evaluating refacto for pharmacovigilance

Conditions: Hemophilia A

Summary: the purpose of this study is to investigate the effectiveness and safety of treatment with refacto under conditions of routine therapy. furthermore a continuous benefit/risk assessment will be done.

non-interventional study: subjects to be selected according to the usual clinical practice of their physician

Eligibility criteria:
inclusion criteria: * proven diagnosis of hemophilia a exclusion criteria: * contraindications according to summary of product characteristics

Keywords: hemophilia a
dosimetric comparison of target volume, heart and left lung in post mastectomy radiotherapy (rt) of left sided breast cancer by free breathing (fb) versus deep inspiration breath hold (dibh) technique

Conditions: Carcinoma Breast; Radiation Therapy for Primary Breast Cancer; Radiation Tolerance; Radiation Induced Cardiac Damage; Radiation Induced Lung Injury (RILI); Radiotherapy; Adverse Effect; Radiotherapy, Adjuvant

Summary: breast cancer is a leading cancer among bangladeshi female. for breast cancer, there are different available treatment options according to the stage of disease. one of the important ones is radiotherapy (rt). various side effects can occur during and after rt. among the late side effects, numerous cardiac and pulmonary problems are significant specially in case of left sided breast cancer. in such cases, patients are being cured from cancer but the treatment itself endangering patients' general health and wellbeing by increasing risk of future life threatening cardiac and pulmonary diseases. studies from around the world have shown that, during rt of left sided breast cancer, holding the breath for certain time after deep inspiration can reduce the radiation doses to heart and left lung without compromising doses to the chest wall. as a result, they can avoid the extra risk of treatment related late toxicities. this study will look at the utility and efficacy of deep inspiration breath hold (dibh) rt over free breathing (fb) rt in reducing the heart and left lung doses without compromising the dose to the target volumes in left sided post mastectomy breast cancer patient, which is the main objective of this study.


Eligibility criteria:
inclusion criteria: 1. histopathologically proven left sided invasive breast cancer patients who underwent modified radical mastectomy. 2. post mastectomy patients for whom radiotherapy including supraclavicular irradiation is indicated. 3. patients having ecog performance status up to 1. exclusion criteria: 1. left sided breast cancer patient underwent bcs. 2. patient received any chemotherapy other than doxorubicin, cyclophosphamide and taxane (paclitaxel/ docetaxel) in any settings (neoadjuvant or adjuvant). 3. patients who have comorbidities that would hinder dibh (extreme obesity, mental disorder, hypoacusis etc.). 4. known case of patients with respiratory diseases. 5. known case of patients with ischemic heart diseases. 6. patients with previous history of radiotherapy to chest. 7. male breast cancer patients. 8. bilateral breast cancer patients. 9. pregnant or lactating women. 10. age ˂ 18 years.

Keywords: deep inspiration breath hold technique post mastectomy radiotherapy
detection of chlamydia (ct) and gonorrhea (ng)

Conditions: Chlamydia; Gonorrhea

Summary: to evaluate the illumigene chlamydia and illumigene gonorrhea assays, using the illumipro-10, with male urine, female urine, physician-collected (medical professional) endocervical swabs and self-collected vaginal swabs taken from symptomatic and asymptomatic patient populations.


Eligibility criteria:
inclusion criteria: 1. male or female 2. any ethnicity or race 3. subject \>14 and \<89 years of age 4. subject who voluntarily gives written informed consent; not applicable for leftover specimens 5. symptomatic or asymptomatic subject who is able and willing to provide the required urine and swab samples for testing for ct and ng 6. leftover urine specimens exclusion criteria: 1. subjects \ 90 years of age 2. subjects who are unwilling to sign the written informed consent; not applicable for leftover specimens 3. subject who is unwilling or unable to provide the required urine and swab samples for testing; not applicable for leftover specimens 4. individuals who have been on antibiotic medications within 10 days. 5. multiple sets of specimens from the same subject at different office visits 6. samples collected or processed in manner other than specified in the study protocol and investigational use only package insert. 7. frozen archived specimens
acute effect of consumption of ground or whole flaxseeds on blood glucose in people with type 2 diabetes

Conditions: Diabetes; Diabetes Type 2; Insulin Resistance

Summary: this study aimed to evaluate the effect of consuming a portion of french bread combined with whole or ground flaxseed on the glycemia of people with dm 2 in a randomized, crossover clinical trial conducted with 16 people with dm 2 who were not using insulin. the main questions of the study were: 1. is flaxseed able to control the glycemia of people with type 2 diabetes? 2. what is the best way to consume flaxseed to control the glycemia of people with type 2 diabetes? the 3 types of bread (whole flaxseed, ground flaxseed and control) were evaluated in interventions, with a 7-day interval between them, for the consumption of the bread and evaluation of the behavior of the glycemia and insulin curve.

this study aimed to evaluate the effect of consuming a portion of french bread combined with whole or ground flaxseed on the blood glucose levels of people with dm 2 in a randomized, crossover clinical trial conducted with 16 people with dm 2 who were not taking insulin. the main questions of the study were: 1. is flaxseed able to control the blood glucose levels of people with type 2 diabetes? 2. what is the best way to consume flaxseed to control the blood glucose levels of people with type 2 diabetes? people with type 2 diabetes mellitus participated in the study, divided into three groups for random consumption of the breads: french bread without flaxseed (control bread), french bread with 30g of whole flaxseed, and french bread with 30g of ground flaxseed. the design was crossover and had a 7-day washout. capillary blood glucose levels were monitored during fasting and at 15, 30, 60, 90 and 120 minutes after ingestion of the breads, while serum glucose and insulin levels were measured during fasting and at peak blood glucose levels, at 60 minutes. in addition, sociodemographic and clinical data (medication use, duration of dm2, bowel habits, sleep, and physical activity), nutritional status, and pre-intervention food consumption with a 24-hour dietary recall were evaluated. the data were analyzed in the r statistical software, through the shapiro-wilk normality test, one-way anova, with tukey or kruskal-wallis post-hoc. the analyses had a significance level of 5%.

Eligibility criteria:
inclusion criteria: * the selection included individuals with dm 2 * of both sexes * adults and elderly individuals without risk of dysphagia * aged 18 years or older * without allergies to the test foods * with the habit of having breakfast (≥4 days a week, with an intake of ≥100 kcal within two hours of waking up) * availability of time for the days planned for the research. exclusion criteria: * the exclusion criteria were applied to individuals diagnosed with another type of diabetes * using exogenous insulin * pregnant or lactating women * smokers * with diseases that affect taste * the gastrointestinal system, and who reported the last intestinal frequency according to the bristol scale 1, 2, 5, 6 and 7.

Keywords: postprandial period glycemic control flax bread
comparison of zenker's diverticulum treatment using peroral endoscopic myotomy and flexible endoscopy septotomy.

Conditions: Zenker Diverticulum; Diverticulum, Esophago-Pharyngeal; Diverticulum, Esophageal; Dysphagia; Gastrointestinal Disease

Summary: the zenker's or pharyngo-esophageal diverticulum is an acquired sac-like outpouching of the mucosa and submucosa layers located dorsally at the pharyngoesophageal junction through killian's dehiscence. it is the most common type of oesophageal diverticula and typically occurs in middle-aged and elderly patients. patients have a significantly reduced quality of life index and numerous complications. treatment is recommended for symptomatic patients and considering the aetiopathogenesis of the disease demands myotomy of the cricopharyngeal muscle. myotomy may be pursued through either open surgical or endoscopic techniques. there is a novel technique, called the peroral endoscopic myotomy (z-poem) for treatment of zenker's diverticulum. the zippy trial designed as prospective, international, multicenter, double-blind, randomized study which will be carried out by experienced endoscopists. the aim of this study will be to evaluate the results of zenker's diverticulum treatment using peroral endoscopic myotomy and to compare its efficacy and safety to flexible endoscopy septotomy. patients at least 18 years old with symptomatic zenker's diverticulum diagnosed on the basis of endoscopic and radiological examinations will be enrolled.

participants will be randomized into one of two groups: (i) z-poem, (ii) flexible endoscopic septotomy. patients with clinical failure will be offered other method of treatment and will be included to observational cohort. the study has been approved by a local bioethics committee

Eligibility criteria:
inclusion criteria: 1. males and females who are 18 years of age and older and are able to comprehend instructions and follow the study procedures and are willing to sign an informed consent form (icf). 2. patients with symptomatic zenker's diverticulum. 3. confirmed diagnosis of zenker's diverticulum based on endoscopic and radiological examinations. 4. size of zenker's diverticulum in the range of 1,5 to 4 cm on radiological examinations. exclusion criteria: 1. lack of written consent for participation in the study. 2. size of zenker's diverticulum \ 4 cm on radiological examination. 3. active cancer. 4. esophageal stricture. 5. eosinophilic esophagitis (eoe). 6. pre-cancerous changes in the esophagus. 7. previous surgical or endoscopic treatment of zenker's diverticulum. 8. presence of chewing deficiencies and/or neurogenic dysphagia. 9. presence of other esophageal motility disorders e.g. achalasia and/or spastic motility disorders. 10. severe systemic diseases which are contraindication to general sedation. 11. severe coagulopathy. 12. pregnancy and breastfeeding.

Keywords: cricopharyngeus myotomy peroral endoscopic myotomy submucosal tunneling endoscopic septum division flexible endoscopy septotomy
sleep apnea in multiple sclerosis positive airway pressure trial

Conditions: Obstructive Sleep Apnea-hypopnea in Multiple Sclerosis Patients

Summary: fatigue is highly prevalent among multiple sclerosis (ms) patients and has pervasive adverse effects on daily functioning and quality of life. the investigators found in a recent study that obstructive sleep apnea-hypopnea (osah) is the most common sleep abnormality in multiple sclerosis (ms) patients. there was also a significant relationship between osah and higher fatigue scores in ms patients. preliminary work from the investigators in this group of subjects shows that treatment of sleep disorders (mostly osah) can improve fatigue and other symptoms in some ms patients. however, it is now necessary to systemically test the effect of osah treatment in a randomized, controlled study, to be sure that it really does improve fatigue and other symptoms. the best treatment for osah in the general population is continuous positive airway pressure (cpap). this treatment has been well tolerated by most ms patients who have used the device at the investigators' center. this project will therefore be a randomized, controlled, clinical trial of cpap in ms patients with osah. the effects of six months of cpap treatment on fatigue as well as sleep quality, somnolence, pain, disability, and quality of life will be studied.


Eligibility criteria:
inclusion criteria: * diagnosis of multiple sclerosis by a neurologist based on standard criteria (annals neurol 2011; 69:292-302) * expanded disability status scale score of 0 to 7.0 * ms-relapse free for \>30 days prior to screening * pittsburgh sleep quality index \> 5 * fatigue severity scale score \>=4 * montreal cognitive assessment (moca) \>= 26 * diagnosis of osah by polysomnography showing ahi \>= 15 events/h of sleep * forced vital capacity \>60% predicted exclusion criteria: * pregnancy or planned pregnancy * psychiatric conditions which could preclude compliance with informed consent, study procedures, or study requirements * other significant neurological, pulmonary, otorhinological, and medical disorders * major depression within the past year * any value of \>1.5 times the upper limit or \<0.75 the lower limit of the reference range for any standard clinical hemogram and biochemistry determinations which is clinically significant * current treatment for osah * presence of another untreated sleep disorder which is clinically significant * very severe osah (safety criterion)defined as an ahi \>30 with either a 4% o2 desaturation index \>15 events/h or work in a safety-critical position or an ess score \>=15
intensive short-term dynamic psychotherapy (istdp) in the emergency department

Conditions: Somatic Complaints of Multiple Types

Summary: objective: somatization of emotions accounts for excess emergency department (ed) visits. intensive short-term dynamic psychotherapy (istdp) has methods to diagnose and manage somatization. we examined the feasibility, acceptability and effectiveness of istdp diagnostic and treatment methods used for patients with repeated ed presentations for medically unexplained physical symptoms (mus)

herein we report the methods and outcomes of rapidly-accessed, emotion-focused diagnostic and treatment services for patients presenting to the ed with medically unexplained symptoms (mus). patients who were assessed and referred by ed physicians will serve as a non-randomized condition controlling for some relevant variables. our a priori hypotheses were that assessed and treated patients would have a reduction in ed visits and self reported symptoms after this intervention and that controls would have a smaller reduction in ed visits if any.

Eligibility criteria:
inclusion criteria: * unexplained symptoms exclusion criteria: * psychosis, substance abuse, suicidality

Keywords: somatization psychosomatic short-term dynamic psychotherapy
erlotinib pharmacokinetics during doxycycline treatment for erlotinib-induced rash

Conditions: Non Small Cell Lung Cancer

Summary: a side effect occurring in a majority of patients taking erlotinib (tarceva®) consists of a skin rash. sometimes, symptoms associated with the rash necessitate erlotinib dose reduction or discontinuation. some physicians have successfully treated the erlotinib-induced rash with doxycycline. at the same time, it has been observed that in patients who develop the erlotinib rash, the cancers respond better to erlotinib treatment. this research study is designed to determine how well doxycycline treats the erlotinib rash and whether doxycycline affects the blood levels of erlotinib.


Eligibility criteria:
inclusion criteria: * males and females 18 years of age or older. * subjects must have started tarceva® therapy within three (3) days of trial enrollment. * patients must have signed informed consent prior to registration on study. * currently receiving erlotinib therapy at 150 mg per day for locally advanced or metastatic nsclc. * patients - both males and females - with reproductive potential (ie, menopausal for less than 1 year and not surgically sterilized) must utilize barrier methods in combination with spermicidal agents for contraception when engaging in sexual intercourse. women of childbearing potential must provide a negative pregnancy test (serum or urine) within 14 days prior to registration. exclusion criteria: * allergy to tetracyclines. * use of concurrent agents for papulopustular rash. * currently receiving anticancer agents other than erlotinib. * inability to interrupt other antibiotic therapy. * current use of topical steroids * current use of systemic immunosuppressants (e.g., methotrexate, cyclosporine, azathioprine, mycophenolate mofetil) * photosensitivity or lupus erythematosus. * active gastroesophageal reflux disease. * women who have a positive pregnancy test or are lactating by history. * ecog performance status ≤3. * self report of current smoking or history of smoking within 60 days of screening, or positive urine cotinine test. * current use of agents that are known to be strong inducers or inhibitors of cytp3a4: * inhibitors: atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfi navir, ritonavir, saquinavir, telithromycin, troleandomycin (tao), voriconazole, grapefruit or grapefruit juice * inducers: rifampicin, rifabutin, rifapentine, phenytoin, carbamazepine, phenobarbital, and st. john's wort * impaired hepatic function (≤ 30 days before randomization): * alkaline phosphatase \> 3x uln * aspartate aminotransferase (ast) \> x uln * alanine aminotransferase (alt) \> 3 x uln * total bilirubin \> 1.5 x uln

Keywords: erlotinib rash supportive care
application of esketamine in anesthesia of autism children

Conditions: Autism Spectrum Disorder

Summary: autism spectrum disorder (asd) is a group of serious neurodevelopmental disorders. autistic children appear with significant frequency for medical services, lots of which requiring procedural sedation or anaesthesia. autistic children have often been described as difficult to sedate or anesthetize due to a variety of asd symptoms. it is a challenging task to provide safe and effective sedation during the procedure of colonic tet for fmt in autism children. the investigators intend to explore an optimum anesthetic regimen for autism children undergoing endoscopic procedures.

autistic children appear with significant frequency for medical services, lots of which requiring procedural sedation or anaesthesia. the participants have often been described as difficult to sedate or anesthetize due to a variety of asd symptoms. it is a challenging task to provide safe and effective sedation during the procedure of colonic tet for fmt in autism children. the primary objective was to compare the clinical efficacy and safety of propofol-esketamine (pe) with propofol-sufentanil (ps) for deep sedation in the procedure of colonic tet in asd children. a secondary objective was to compare adverse events (aes) and recovery in those children during/after either pe or ps sedation.

Eligibility criteria:
inclusion criteria: * (1) aged 2-12 years; * (2) diagnosed with asd by pediatric psychiatrists in accordance with the criteria in the fifth edition of diagnostic and statistical manual of mental disorders (dsm-v); * (3) evaluated as american society of anesthesiologists (asa) physical status i-ii; * (4) scheduled for colonic tet procedure. exclusion criteria: * (1) oral sedation (premedication) before intravenous catheter placement; * (2) any contraindication to study medications; * (3) other circumstances in which the investigator determined that a patient was not suitable for participation in the clinical trial.

Keywords: fecal microbiota transplantation transendoscopic enteral tube gut microbiota anaesthesia
radiologist diagnostic performance versus artificial intelligence (ai)

Conditions: Painful Hip; Fonctional Impotence After Minor Trauma (Fall)

Summary: in france, femoral neck fracture is mainly detected with interpretation of pelvis/hip x-ray imaging (french health authority recommandation). however, up to 10% of fractures are not identified or misdiagnosed, especially in patients admitted to the emergency department. indeed, radiologists may be subject to excessive work, wich cause the risk of inaccurate on x-rays diagnosis. the artificial intelligence (ai) begins study the detection of fratures on medical imaging. in this retropective study, this technology developed by gleamer company is tested to evaluate the detection rate of hip fracture and specifically femoral neck fracture, compared to the radiologist diagnostic, in eldery patients admitted in emergency department. ai could optimize the diagnostic performance of radiologists (increase of confidence level) and improve the efficiency of suspected fractures sorting from emergency department.


Eligibility criteria:
inclusion criteria: * patients aged 60 and older * minor trauma * admitted in emergency department for painful hip/fonctional impotence after minor trauma * takes at least a hip radiography exclusion criteria: * painful before the minor trauma * important trauma

Keywords: medical imaging diagnosis frature detection artificial intelligence femoral neck fracture hip x-ray radiography
rives technique versus lichtenstein repair for primary inguinal hernia

Conditions: Primary Inguinal Hernia

Summary: lichtenstein technique, inserting a mesh over the inguinal cord in the neurological plane, is considered the standard of inguinal hernia repair, but it has 4% recurrence and 12% chronic postoperative pain. rives technique inserts the mesh in the preperitoneal space behind the neurological plane and the muscular plane, thus better fulfilling the principle of hydrostatics.

these techniques have not been compared randomly for assessment of chronic pain, postoperative complications and recurrences

Eligibility criteria:
inclusion criteria: men or women aged between 18 and 93 years (inclusive) at the time of the first screening visit. they must provide signed written informed consent and agree to comply the study protocol exclusion criteria: refusal to give informed consent. refusal to participate giant inguinal hernias

Keywords: rives technique lichtenstein repair