Kornimate/medical-research-clean huggingface dataset:
kinesiophobia in postmenopausal osteoporosis

Conditions: Osteoporosis

Summary: this study aims to evaluate kinesiophobia levels in postmenopausal women with osteoporosis compared to a healthy control group and to explore the relationships between kinesiophobia and various psychosocial factors, including quality of life, fear of falling, and symptoms of depression and anxiety.

this cross-sectional, controlled study aims to explore kinesiophobia levels in postmenopausal women with osteoporosis compared to healthy age-matched controls. postmenopausal osteoporosis is a systemic condition characterized by reduced bone mineral density, which increases fracture risk and can significantly affect individuals' physical activity and overall quality of life. kinesiophobia, or the irrational fear of movement due to perceived injury risk, can further exacerbate this issue by restricting physical activity, which is vital for maintaining bone health. the study will involve 60 postmenopausal women diagnosed with osteoporosis and 60 healthy age-matched women without osteoporosis or osteopenia. participants will be recruited from the outpatient clinics of i̇stanbul physical therapy and rehabilitation training and research hospital between january 21, 2024, and february 21, 2024. the study will assess kinesiophobia using the turkish version of the tampa scale for kinesiophobia (tsk), quality of life with the quality of life questionnaire of the european foundation for osteoporosis (qualeffo-41), and symptoms of depression and anxiety using the hospital anxiety and depression scale (hads). additionally, the tinetti falls efficacy scale (tfes) will evaluate fear of falling, and bone mineral density will be measured using dual-energy x-ray absorptiometry (dxa).

Eligibility criteria:
inclusion criteria: * diagnosis: participants must be diagnosed with postmenopausal osteoporosis and have been under follow-up for at least six months. * age: individuals must be 50 years or older. * health status: participants must have excluded secondary causes of osteoporosis. exclusion criteria: * comorbid conditions: presence of other musculoskeletal, neurological, or psychiatric diseases that could influence kinesiophobia or pain. * cognitive or communication difficulties: any cognitive dysfunction or communication issues that might impair the participant's ability to engage with the study. * acute conditions: presence of acute painful conditions that might affect the results. * medications: use of medications or presence of diseases that could cause balance or functional disorders.

Keywords: osteoporosis quality of life kinesiophobia depression anxiety
role of gut microbiota in the pathophysiology of aseptic abscesses

Conditions: Aseptic Abscess Syndrome

Summary: aseptic abscess syndrome (aa) is a rare entity characterized by the occurrence of deep abscesses with no germ found. antibiotic therapy is ineffective and they are sensitive to anti-inflammatory treatment with corticosteroids. gut microbiota is important for the development of the immune system. in crohn's disease which is frequently associated with aa syndrome, dysbiosis is found but could also be involved in the immune response at a distance from the gut. stool, blood, saliva and urine samples will be taken from the patients included and their controls in the centers where they are followed. these biological samples will be transported to clermont ferrand using the same procedure (transporter and dry ice) where the following analyses will be performed: microbiota on stool and saliva, short chain fatty acids on stool and lymphocyte study on blood.

* included patients will be adult patients meeting the diagnostic criteria for aseptic abscess syndrome described by andré et al. * controls will be adults without aseptic abscess syndrome living in the same environment as the patients, whether related to the patient or not. patients and controls must be able to provide informed consent and be affiliated with the french social security system.

Eligibility criteria:
inclusion criteria: * for cases: adult patients meeting the diagnostic criteria for aseptic abscess syndrome described by andré et al: * deep abscesses on radiological examination with neutrophilic features proven by pathological analysis of a surgical specimen or biopsy when performed * negative blood cultures, negative serological tests for bacteria, including always yersinia enterocolitica, and, during surgery or aspiration, sterile pus (with standard cultures, baar and fungal tests) failure of antibiotic therapy, when prescribed, after at least 2 weeks for conventional antibiotic therapy and at least 3 months for anti-tuberculosis treatment * rapid clinical improvement the day after the prescription of corticosteroids (at least 1/2 mg/kg prednisone or equivalent) followed by radiological improvement after 1 month of corticosteroids, sometimes in association with immunosuppressive treatments. for controls: adult person living in the same environment as the case to which it is matched. adult person living in the same household or near the patient. for cases and controls: * ability to provide informed consent. * membership in the social security system. exclusion criteria: * pregnant women. incapable patients patients deprived of liberty antibiotic therapy administered within 6 weeks prior to inclusion.

Keywords: aseptic abscess syndrome comparative study pathophysiology
dynamic changes of tim-3 on monocytes and soluble tim-3 in patients with sepsis

Conditions: Sepsis; Severe Sepsis; Septic Shock

Summary: in this study, the investigators will dynamically detect the expression of an immune regulator- t cell ig and mucin domain protein 3 (tim-3) in patient with sepsis.

in this study, we will collect the peripheral blood of 1,3,5,7,10,14 day after diagnose of sepsis.all the patients rolled in this study will be divided into three groups which is sepsis, severe sepsis and septic shock group according their severity. then,the flow cytometry will be used to detect the express of tim-3 on monocyte and elisa will be used to exam the plasm soluble tim-3.il-6,il-10,il-12 and tnf-αin the peripheral blood will also be detected. we would like to find a new marker to predict the severity and prognosis of sepsis patients.

Eligibility criteria:
inclusion criteria: * more than one of the following: clinical manifestations: (1) a body temperature greater than 38℃ or less than 36℃; (2) a heart rate greater than 90 beats/minute; (3)tachypnea, manifested by a respiratory rate greater than 20 breaths per minute, or hyperventilation, as indicated by a paco2 of less than 32 mmhg; and (4)an alteration in the white blood cell count, such as a count greater than 12×10\^9/l, a count less than 4×10\^9/l, or the presence of more than 10 percent immature neutrophils exclusion criteria: * (1)patients younger than 18 years of age; (2)agranulocytosis (granulocyte counts,0.5×10\^9/l); (3) those discharged within 24 h; (4) those diagnosed with hiv infection or cancer; and (5) patients who refused to participate.
optimized and personalized trans-cranial brain stimulation in partial refractory epilepsies

Conditions: Transcranial Electric Stimulation; tDCS; Epilepsy; Pharmacoresistant; HR EEG; Children

Summary: epilepsy is one of the most common neurological diseases, affecting between 0.5% and 1% of the general population. therefore, new diagnostic and treatment methods are having a big impact on society. epilepsy is also one of the most commonly diagnosed pediatric neurological disorders, with long-term implications for the quality of life of those affected and their relatives. in only two-thirds of cases, seizures can be adequately controlled with anticonvulsant drug therapy. for other patients with a drug-resistant focal epilepsy (up to around 2 million in europe) epilepsy surgery is currently the most effective treatment. however, only 15-20% of these drug-resistant patients are eligible for epilepsy surgery. this is either because the cortical epileptogenic zone cannot be localized with sufficient precision with standard diagnostic means, or because the epileptogenic zone overlaps meaningful cortical areas, so that it cannot be surgically removed without considerable neurological deficit.


Eligibility criteria:
inclusion criteria: * any patient, male or female aged 1 to 18, with refractory partial epilepsy considered potentially surgical according to the definition of ilae. drug-resistant epilepsy can be defined as the failure of adequate therapeutic trials of two antiepileptics (either monotherapy or in combination) so that the patient is free from seizures on a lasting basis. * any epileptic patient with interictal epileptic spikes on his standard or high resolution eeg and or on the magnetoencephalography examination * any epileptic patient undergoing a structural mri * any patient who has agreed to participate in the perepi 1 study allowing the optimization of the location of epileptic sources and the modelling of the optimization of the parameters of transcranial electrical stimulation * patients who have at least 4 seizures per month exclusion criteria: * patient not meeting the age criteria * and/or presenting generalized epilepsy * and/or presenting diffuse interictal peaks and/or presenting a serious alteration of the general condition and vital functions * and/or in the event of refusal by one of the parents or the child * pregnant, parturient or breastfeeding woman. * contraindication to the use of mc-tdcs stimulation without seizure

Keywords: transcranial electric stimulation tdcs epilepsy pharmacoresistant hr eeg children
pre-emptive opioid treatment to prevent rebound pain after arthroscopic rotator cuff repair and/or acromioplasty under general anesthesia and interscalene block

Conditions: Rotator Cuff Injury; Pain

Summary: arthroscopic shoulder rotator cuff repair and acromioplasty are associated with severe postoperative pain. the interscalene block (isb) is commonly used for this type of surgery, providing analgesia by anesthetizing the nerves that supply the shoulder. although the nerve block provides extremely effective analgesia for the first 6-8 hours, patients experience severe pain once its effect has regressed. this study will assess whether a single dose of oral hydromorphone controlled release, given to overlap the waning of the isb, will improve postoperative pain control and reduce the incidence of rebound pain. seventy patients undergoing rotator cuff repair will receive standardized isb and general anesthesia for the surgery. six hours (+/- 1 hour) after isb, the patients will randomly receive either a single oral dose of 2 mg hydromorphone (immediate release formulation) or placebo. the patient will be then discharged home with a prescription for multimodal analgesia, which is the standard of care. patients will be given a diary to record their pain scores and track use of analgesic medications for 24 hours. twenty-four hours after the isb, the patients will receive a phone call from a nurse as per the standard of care. during this phone call, questions will be asked about their pain control. if a single dose of pre-emptive hydromorphone is demonstrated to be safe and effective, it will lead to change in practice of how we manage pain after rotator cuff repair. furthermore, the finding of this study may apply to similar surgical procedures (such as elbow, knee and ankle repairs) that are associated with rebound pain when the nerve block wears off.


Eligibility criteria:
inclusion criteria: * age 18-65 * scheduled to receive isb and general anesthesia as a day surgery patient for rotator cuff repair and acromioplasty, as a part of planned routine care exclusion criteria: * allergy, sensitivity, or absolute contraindications to any of the medications involved in the study * preexisting cns depression, or taking regularly medication that cause cns depression * preexisting cognitive deficits, dementia, or delirium * severe respiratory comorbidities (e.g. chronic obstructive pulmonary disease, pneumonia, respiratory failure) * sleep disordered breathing (diagnosed osa, obesity hypoventilation syndrome) * pregnancy and breast feeding * history of chronic pain or regular (at least once daily) opioid use preoperatively * renal impairment - crcl ≤60 ml/minute * not fluent in english to be able to participate in the study process, including consent and phone interview * body mass index \>35 * inability to take oral medication.

Keywords: rotator cuff repair interscalene block hydromorphone pain rebound pain acromioplasty
effects of a dexmedetomidine on quality of recovery 40 and postoperative nausea and vomiting in breast cancer surgery

Conditions: Breast Cancer

Summary: postoperative nausea and vomiting (ponv) is common following beast surgery. dexmedetomidine was reported to a reduced ponv due to opioid-sparing effect. it is not clear if dexmedetomidine itself is useful on reducing ponv. the hypothesis of present study: intraoperative application of single dose dexmedetomidine (0.5 mcg/kg) is is effective than placebo for reducing of ponv and improve postoperative quality of recovery score within 48 postoperative hours.

this study was approved by the institutional review board of severance hospital, yonsei university health system. after written informed consent was obtained from all patients, aged 20-75 years with asa physical status class i-ii who were scheduled breast cancer surgery under general anaesthesia were enrolled in this study all the patients were randomly assigned to receive dexmedetomidine or placebo during surgery. the primary outcome was quality of recovery determined by qor-40 in the first 24h after surgery.the secondary outcome measure was ponv assessed by visual analogue scale every 6 hours within 48 postoperative hours.

Eligibility criteria:
inclusion criteria: * asa i, ii * aged 20-70 years * undergoing breast cancer surgery exclusion criteria: * caod * bradycardia * qt prolongation
evaluation of the duration of bupivacaine spinal block in orthopedic procedures with and without epinephrine wash

Conditions: Arthropathy of Hip; Arthropathy of Knee

Summary: bupivacaine spinal is commonly performed as the primary anesthetic for orthopedic procedures. in some cases the duration of the block is inadequate. an epinephrine wash is sometimes performed to prolong the duration of the block. the epinephrine wash may prolong the duration of the block, and if it does, to what extent?


Eligibility criteria:
inclusion criteria: * 18 years of age or older * patients scheduled for total hip or knee replacement exclusion criteria: * patients taking anticoagulation * infection at or near the intended needle insertion site * patients with sacral decubitus ulcer at or near the intended needle insertion site aortic stenosis * complex spine anatomy * asa class greater than iii * failed sab as determined by the staff anesthesiologist
effect of prophylactic prosthesis placement with versus without omega-3 at the umbilical trocar level on surgical site infection and herniation after laparoscopic cholecystectomy in patients with risk factors.

Conditions: Surgical Site Infection

Summary: title: effect of prophylactic prosthesis placement with versus without omega-3 at the umbilical trocar level on surgical site infection and herniation after laparoscopic cholecystectomy in patients with risk factors. objective: to evaluate whether the placement of a synthetic prosthesis with omega-3 in its composition at the level of the umbilical trocar after laparoscopic cholecystectomy versus the placement of a synthetic umbilical prosthesis without omega-3 in its composition decreases the rate of surgical site infection (ssi) and trocar site hernia (tsh) in patients with risk factors for infection and herniation.

methods: a prospective study was conducted with 2 consecutive series of patients operated on for cholelithiasis who also had some of the following risk factors that increase the occurrence of ssi or tsh: bmi \> 30 kg/m2, diabetes mellitus, age \> 65 years and chronic obstructive pulmonary disease. a circular prosthesis with an omega-3 coating was placed in patients in group a, and a prosthesis without omega-3 in its composition was placed in patients in group b. the main variables evaluated were the occurrence of ssi and tsh.

Eligibility criteria:
inclusion criteria: the included patients were between the ages of 18 and 90 years, underwent elective laparoscopic cholecystectomy for symptomatic cholelithiasis and had one of the following risk factors that increase the occurrence of ssi or tsih: * obesity: with a body mass index (bmi) \> 30 kg/m2. * diabetes mellitus (insulin dependent or who take oral antidiabetic drugs), * age \> 65 years and * copd treated with inhalers. exclusion criteria: * nonfulfillment of the inclusion criteria. * conversion to laparotomy during the surgical procedure * non-acceptance of participation in the study by the patient * loss to follow-up.
us imaging for the assessment of luts

Conditions: Lower Urinary Tract Symptoms; BPH

Summary: the purpose of this research is to develop an ultrasound (us) based urodynamics (uds) evaluation of voiding based on successful magnetic resonance imaging (mri)-uds evaluation. both us and mri are non-invasive imaging techniques, but us is a more cost-effective and widely available technology. 80 participants will be enrolled and will be on study for up to 2.5 hours (1.5 hour mri and 1 hour us).

the mri - uds technique provides voiding flow rates and bladder pressures which can be used to calculate the widely used metrics of obstruction (bladder outlet obstruction index, booi) and contractility (bladder contractility index, bci). in a preliminary study, values for maximum flow (qmax) and detrusor pressure at maximum flow (pdetqmax) were obtained from mri-uds for patients with bph/luts. these results closely correlated with multichannel urodynamics (mcud). men with bph/luts and age-matched controls will undergo a comprehensive protocol of dynamic mri, 3d ultrasound and multi-channel urodynamics (mcud) to evaluate and validate this novel methodology. specific aims include: aim 1. develop an ultrasound/cfd based urodynamics (us-uds) method. a protocol combining 3d us imaging and cfd analysis will be developed. this approach will be validated both in vitro and in vivo, first in an anatomically realistic model and then in control human subjects. aim 2. establish the accuracy of voiding metrics determined with ultrasound urodynamics (us-uds). mcud, mri-uds and the new us-uds protocols will all be performed to evaluate voiding in patients with bph/luts and healthy controls. urodynamic metrics derived from ultrasound will be compared to those obtained from the reference clinical standard mcud and mri-uds. aim 3. develop an optical velocimetry methods that allows the non-invasive quantification of urine velocity while voiding. a setup of high speed cameras will be assembled and utilized to optically image the voiding stream in all subjects recruited for aims 1 and 2.

Eligibility criteria:
inclusion criteria: patients with bph/luts * age 18-80 years old * diagnosed with bph/luts with or without obstruction exclusion criteria: * patients with contraindication to mri and/or gbca contrast agent. diabetic subjects will not receive contrast. * history of overt neurologic disease other than diabetic neuropathy, urinary tract infection within the last 4 weeks or recent history of urinary retention (within the last 4 weeks). inclusion criteria: healthy volunteers - age 18-80 years old not experiencing any symptoms consistent with luts exclusion criteria: * patients with contraindication to mri and/or gbca contrast agent. * currently taking medications with known effects on the bladder, overt neurologic disease other than diabetic neuropathy, urinary tract infection within the last 4 weeks or urinary retention symptoms.
the effect of physical exercise after childbirth

Conditions: Postpartum

Summary: postpartum women are recommended to engage in physical activity including moderate intensity aerobic and strengthening exercises for at least 150 minutes within one week. the benefits of postpartum exercise include strengthening abdominal muscles, increasing energy, preventing postpartum depression, reducing stress, improving sleep quality and losing excess weight gained during pregnancy. however, activity levels of women who have given birth are reported to be very low, despite the great benefits of exercise on physical and mental health. in a meta-analysis, it was stated that exercise can be used for counseling and therapeutic purposes to improve postpartum quality of life and reduce fatigue.

although studies evaluating sleep quality, quality of life and fatigue of postpartum women have been found in the literature, no study evaluating the effect of postpartum physical exercise in turkey has been found yet. accordingly, this study was planned to evaluate the effect of physical exercise on sleep quality, quality of life and fatigue in postpartum women.

Eligibility criteria:
inclusion criteria: * be over 18 years of age * be able to read and write in turkish * be in the 24th postpartum hour * have had a vaginal delivery * have had a single live birth -have had a single live birth * be primiparous * have given birth at term -have given birth at term * accept to participate in the study * have no musculoskeletal disorder preventing exercise * have no chronic disorder preventing exercise * using a smart phone exclusion criteria: * having a regular exercise program * having a baby in intensive care * having a psychiatric treatment in the postpartum period * being multiparous * willing to voluntarily leave the study * did not perform the exercises more than two days in a week

Keywords: exercise quality of life fatigue sleep postpartum
enhancing the lucentis (ranibizumab) management of choroidal neovascular membranes with hyperspectral imaging

Conditions: Macular Degeneration; Choroidal Neovascularization

Summary: clinical trial investigating the role of hyperspectral imaging in the management of patients undergoing standard clinical treatment for naive neovascular choroidal membranes in age-related macular degeneration.

observational trial of patients with choroidal neovascular membranes treated with lucentis. exploration and validation of a new form of retinal imaging called hyperspectral imaging. inclusion: patients meet eligibility criteria other than ffa diagnosis and who are diagnosed with suspected exudative cnv on the oct. (n=100 eyes) procedure: monthly doses of lucentis. oct scans will be taken prior to each injection. hsi image taken at baseline and at the 9-month time point. time frame: 6 months recruitment + 12 months follow-up + 6 months analysis. all recruited patients will receive monthly doses of lucentis as per the cmbs-approved protocol to allow comparison with other published studies. lucentis will be administered in accordance with published standards of practice. oct scans will be taken prior to each injection. hsi image will be taken at baseline, three months and 9-month time points

Eligibility criteria:
inclusion criteria: * provide signed and dated informed consent form * willing to comply with all study procedures and be available for the duration of the study * male or female, aged 50-80 * in sufficiently good general health to be able to have a ffa * cnv diagnosed by oct * vision equal or better than 6/60 in the study eye * no prior treatment in the study eye with anti-vegf medication exclusion criteria * significant media opacity. * known allergic reactions to components of the study product(s). * anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.

Keywords: hyperspectral imaging, ranibizumab