Kornimate/medical-research-clean huggingface dataset:
dissemination of comprehensive behavioral intervention for tics (cbit) to occupational therapists: a feasibility study

Conditions: Tourette Disorder; Chronic Tic Disorder

Summary: comprehensive behavioral intervention for tics (cbit) is an evidence based intervention for tic disorders. a recent scientific review of research priorities completed by the tourette syndrome association recommended widespread dissemination of cbit as an important next step in services delivery research. given early evidence that occupational therapists can deliver cbit effectively, a dissemination strategy using occupational therapists may improve accessibility to this treatment, at lower cost and with decreased stigma. thus the goal of this study is to develop and test a training and dissemination model with occupational therapists (ots) using an expert, multi-disciplinary team at weill cornell/new york presbyterian hospital (wc/nyph) and university of alabama at birmingham (uab). the investigators have adapted cbit, the gold-standard behavioral intervention program for children with tic disorders (woods et al, 2008a,b), for eventual use in ot programs across the country.

cbit training materials designed by the study team have been used to train occupational therapists (ots) at wc/nyph and uab to deliver cbit, and data has been collected to measure training acceptability. ots will be supervised in the practice of cbit with youth in the new york city and birmingham areas. pre- and post-treatment assessment measures will be collected from 16 families (8 from each site) to evaluate intervention acceptability, feasibility, and fidelity. patient and parent satisfaction of cbit-ot will also be documented. the investigators will look within subjects to ascertain change in reported tic severity. this study is designed to determine the feasibility and acceptability of treatment, feasibility of research design, as well as demonstrate the ability to disseminate the study protocol to a new care discipline in methodologically rigorous fashion across multiple sites.

Eligibility criteria:
inclusion criteria: * age 7-17 * presence of motor and/or vocal tics for at least 6 months * tics are of at least moderate clinical severity as evidenced by a clinical global impressions severity (cgi-s) score of 4 or higher (tic symptoms clearly noticeable to family and occasionally to families and associated with at least some minimal level of distress and/or interference. * iq estimate of 70 or higher * comorbid disorder (e.g., adhd, ocd,odd) will be allowed provided that the tic symptoms are of primary concern to parents and comorbid symptoms are not of sufficient severity to require immediate treatment other than that provided by the current study. * pre-existing stable medication, tic or otherwise, will also be allowed provided the family agrees to refrain from med changes over the course of the study if at all possible. * sufficient command of the english language to comply with study protocol. exclusion criteria: * free of pdd or other developmental disability

Keywords: tourette's tic disorder cbit dissemination occupational therapist
stepped care treatment for binge-eating

Conditions: Binge Eating Disorder

Summary: temple university is looking for women to participate in a study to evaluate the treatment options available to women living with binge eating disorder. binge-eating disorder is a significant public health problem for women. despite this, there is limited research on how best to treat this disorder at varying levels of severity. the purpose of this nimh-funded study is to enroll individuals in a brief form of cognitive-behavior therapy. if more intense treatment is needed, individuals will be randomly assigned to more intensive group and individual treatments (cognitive-behavior therapy or dialectical behavior therapy). both of these treatments are talking therapies that have been adapted for women living with binge-eating disorder and are free of charge.


Eligibility criteria:
inclusion criteria: * adult female, 18 years to 60 years * meets dsm-iv criteria for binge eating disorder * resides within commuting distance * consents to research protocol, i.e. * 18-24 months in assessment and treatment * willing to be part of a biological assessment/physiological assessment * have to be prepared that they will receive a brief individual treatment and if this does not work for them, that they will receive more intensive treatment including both group and individual treatment. * agreement not to see other health professionals unless recommended * seeing their own primary care physician/nurse practitioner for medical screening prior to study (i.e., before being allocated a guided self-help therapist) * payment for their own medical assessment, monitoring, and medication if needed exclusion criteria: * anorexia nervosa * schizophrenia, schizophreniform, or schizoaffective disorders, psychosis nos, or bipolar mood disorder * needs priority treatment for other debilitating conditions, e.g. current substance dependence requiring inpatient detox * chronic absence of shelter * iq less than 70 * impending jail/prison, court order to treatment, court order to treatment or to jail, or agency order to treatment or to loss of child custody (due to consequent inability to freely drop-out of treatment) * is pregnant, plans to become pregnant during treatment, or becomes pregnant before random assignment to study condition * medical instability * has had or is seeking gastric bypass surgery * on anti-seizure medication, beta-blockers, asthma medication, medication for heart disease, or any other medication that affects appetite or weight * psychotropics are acceptable if the doses are stable for at least 3 months prior to screening

Keywords: binge eating disorder overeating binge eating women overweight compulsive overeating
hdl target of covid19 ? analysis on the caregivers of the reunion university hospital

Conditions: SARS-CoV Infection

Summary: since december 2019, the severe acute respiratory syndrome-coronavirus-2 (sars-cov-2) pandemic has spread around the world. the people most exposed to this virus remain the healthcare personnel who are on the front line in the fight against this pandemic. due to the delayed nature of the pandemic in reunion island and its insular geographical situation, the study of the voluntary medical personnel will allow the investigators to establish a longitudinal follow-up of the anomalies of the lipidic balance in relation to the exposure to the sars-cov virus. 2. during bacterial infections, the lipid profiles are profoundly modified with very significant reductions in plasma cholesterol levels, ldl-c but especially hdl-c whose concentrations are particularly low. lipid profiles are altered during viral infections, for example, the severity of dengue is inversely correlated with total cholesterol and ldl-c but not with hdl-c levels, according to a recent meta-analysis. the hepatitis c virus circulates in serum linked to lipoproteins rich in triglycerides and hdl can facilitate its entry into cells via scavenger receptor class b type 1 (srb1). likewise, it has been shown that apoa1 can bind to the dengue virus and increase its infectivity by promoting its entry into cells, also via srb1. at the moment, nothing is known about the lipid profiles in subjects with sars-cov-2. the investigator hypothesize that a drop in plasma hdl-c levels and a change in their size during infection could justify future therapeutic approaches aimed at supplementing the subjects most at risk of pulmonary complications. in a model of pseudomonas aeruginosa pneumonia in mice, investigators have shown that the injection of reconstituted hdl allowed to limit the pulmonary inflammation and the deleterious consequences of the infection. the investigator propose to study not only the lipid profiles in subjects who are infected with sars-cov-2 but also the polymorphisms of genes involved in the regulation of lipoprotein levels like that of cholesterol ester-transfer protein (cetp) depending on the developed forms, symptomatic or not.


Eligibility criteria:
inclusion criteria: * caregiver in reunion island university hospital center * practicing in a care service possibly exposed to the coronavirus * signed consent exclusion criteria: * refusal to participate * already infected by covid19
evaluation of obex® in overweight and obesity

Conditions: Overweight and Obesity

Summary: * obesity is an important and growing worldwide * obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer * diverse adverse events have been reported with the use of antiobesity drugs. * several articles describe the beneficial effect of several specific components of the obex® supplement on weight loss, in the reduction of waist circumference, suppression of appetite, decrease fasting glucose levels, improvement of insulin sensitivity and β cells function. * therefore, the administration of obex in overweight and obese patients could be an excellent strategy to induce weight loss and ameliorate the metabolic disturbances related to obesity and overweight.


Eligibility criteria:
inclusion criteria: * patients who fulfill the diagnosis criteria of overweight or obesity (bmi ≥ 25.0 and less than 40). * age between 20 and 65 years old. * values of fasting glucose \< 7.0 mmol / l and at two hours \< 11.1 mmol / l during glucose tolerance test (ogtt). * written informed consent of participation in the study. exclusion criteria: * thyroid dysfunction (hypo or hyperthyroidism). * type 1 or type 2 diabetes. * prediabetes treated with oral agents. * alterations of lipids treated with drugs. * medicine consumption of or dietary supplements that influence the reduction of body weight. * consumption of steroids or prolonged use of them (last 3 months). * treatment with immunosuppressive drugs. * chronic diseases (of the hepatic, renal and cardiovascular systems, pancreatitis or some type of malignancy condition) or acute at the time of inclusion. * insulin resistance due to diseases such as acromegaly, endogenous hypercortisolism, polycystic ovarian syndrome or hyperprolactinemia. * history of symptomatic hypoglycaemia. * history of chronic debilitating diseases, anemia and collagen diseases. * history or existence psychological illness with eating disorders or toxicity. * history of alcoholism or drug dependence. * inability to comply with the instructions of the investigation. * severe infections at the time of inclusion. * women of childbearing age who use hormonal contraceptives (oral or injectable). * pregnant or breastfeeding. * known sensitivity to any of the components of the formulation * gynoid fat distribution.

Keywords: overweight obesity nutritional supplement weight loss waist
outcomes of local perforator flaps in oncoplastic surgery

Conditions: Breast Tumor; Perforator Flap; Breast Cancer; Oncoplasty; Breast-Q

Summary: this is a single center experience of using local perforator flaps in partial breast reconstruction for breast tumors while evaluating cosmetic outcomes, patient satisfaction and well-being using a validated self-administered questionnaire.

background \& objectives: various oncoplastic techniques have emerged over the years to preserve breast cosmesis and symmetry without compromising the principles of tumor excision. one of the newer techniques for breast volume replacement to achieve symmetry and cosmesis is the use of fasciocutaneous pedicled chest wall perforator flaps or local perforator flaps (lpf). the objectives of this study are to document the details of the surgical procedure as well as patient-reported satisfaction and well-being following the already performed surgical procedure using a validated breast-q tool among pakistani women. materials \& methods: this prospective cross-sectional study will be conducted by enrolling all the 25 female patients who have undergone lpf for breast tumors at the aga khan university hospital, karachi. data related to the procedure will be collected on a pre-designed proforma. cosmetic outcomes and patient satisfaction will be evaluated using 2 scales from breast-q bct domain version 2.0. the questionnaire will be self-administered by the patients during their routine follow-up in the clinic. data will be analyzed using the statistical package for social sciences (spss) version 23. mean (sd) / median (iqr) will be computed for quantitative variables and frequency and percentages will be calculated for qualitative variables. 2 sample t-test will be applied. p-value ≤0.05 will be considered significant.

Eligibility criteria:
inclusion criteria: * all female patients suitable for breast conservation who underwent a pedicled fasciocutaneous perforator flap for immediate partial breast reconstruction at the breast surgery section exclusion criteria: * for evaluation of surgical techniques, since this was a review of cases already operated, no cases were excluded. * for cosmetic outcomes and patient satisfaction, patients who lost to follow, expired or did not give consent to participate in the study were excluded.

Keywords: local perforator flaps breast cancer oncoplastic breast conserving surgery breast-q breast surgery
umblical pilonidal sinus evaluation

Conditions: Pilonidal Sinus

Summary: purpose: pilonidal sinus disease (psd) is a chronic inflammatory condition of skin due to implanted loose hair. psd is commonly seen in sacrococcygeal region, but can also be seen in axilla, perineum, suprapubic regions, on hands and umbilicus. the aim of this project was to find factors influencing the development and treatment of umbilical pilonidal sinus. material and methods: in this cross-sectional prospective study, the investigators evaulated 82 (19 female, 63 male) patients with a history of umbilical pilonidal disease (e.g. predisposing factors, treatment modalities) between 2012 and 2020.

in this study, participants were volunteer patients admitted to erzincan university medical faculty to the general surgery outpatient clinic between march of 2012 and december of 2020 with umbilical symptoms such as umbilical discharge and umbilical pain. all patients were diagnosed by physical examination confirmed with ultrasonography . patients with diseases other than umbilical sinus were excluded from the study. examined patients' characteristics include age, gender, intergluteal sinus disease history, family history, belly shaving histoy, daily shower, treatment modality and healing status. there were 3 treatment modalities: conservative approach (daily shower, shaving, antibitics if infected); topical silver nitrate treatment; surgical operation for umbilical sinus as excracting the hairs from the sinus ± excising the sinus. to determine if "healed" the investigators followed up our patients ensuring no symptoms for a minimum 2 years. chi-square tests were conducted to compare the distribution of categorical variables. age was analyzed as a continuous variable with a t-test. univariable and multivariable logistic regression models were used to calculate odds ratios and 95% confidence intervals. p-values of less than 0.05 were considered statistically significant. statistical analyses were conducted with r version of 3.6.1 (r foundation for statistical computing, vienna, austria, https://www.r-project.org) software packages.

Eligibility criteria:
inclusion criteria: * all patients with umblical pilonidal sinus exclusion criteria: * no disease
community burden of mg infection

Conditions: Sexually Transmitted Infection (STI); Mycoplasma Genitalium Infection

Summary: objective: to assess the burden and the transmission dynamics of mycoplasma genitalium (mg) infection in men who have sex with men in hong kong. design and setting: involving a) a cross-sectional study (completion of an online self-administered survey, followed by self-sampling for testing in the laboratory, and performance of hiv self-test); b) a mathematical modelling study to simulate the transmission dynamics of mg infection and resistant mg infection and compare the impacts of test-and-treat strategies. participants: around 920 men who have sex with men would be recruited

cross-sectional study: a total of 920 men who have sex with men aged 18 or above and normally living in hong kong would be recruited. eligible participants would be asked to complete a self-administered online survey, submit self-collected urine specimen and rectal swabs for chlamydia trachomatis, neisseria gonorrhoeae, and mycoplasma genitalium testing in the laboratory, and submit hiv self-test results. mathematical modelling study: a compartmental model would be constructed to simulate the transmission dynamics of mg infection and resistant mg infection, and analyse the impact of different test-and-treat strategies.

Eligibility criteria:
inclusion criteria: * men who have sex with men aged 18 or above, normally living in hong kong, and could communicate in written and spoken english or chinese exclusion criteria: * cannot provide consent

Keywords: mycoplasma genitalium chlamydia trachomatis neisseria gonorrhoeae men who have sex with men
functional imaging of social cognition in premanifest huntington's disease

Conditions: Huntington's Disease

Summary: huntington's disease (hd) is a genetic progressive fatal neurodegenerative disorder. in the western world it affects 5-10 persons per 100000. the main brain changes include the loss of brain cells in subcortical structures. the symptoms of hd include involuntary movements, cognitive deterioration and behavioural disturbances. it has been shown that changes in emotion comprehension occur before the onset of the motor symptoms (prehd). this deficit in perception of emotions has been primarily investigated by means of facial expressions. however, emotions can also be expressed through body language. here, the investigators propose to investigate whether the emotion comprehension deficit in prehd also includes body language comprehension.

the investigators will perform a detailed evaluation of body language comprehension abilities in persons that carry the genetic mutation causing hd, but who do not show any movement symptoms yet. in addition, the associated changes in brain structure and function will be studied. the aim is to perform the study with the same group of participants who participated in a recent study carried on by this research group, in which the functional brain changes associated with increased irritability were investigated. this will allow to relate emotion experience with emotion perception. the results of the study may provide a target to further develop therapeutic interventions and aid caregivers of prehd subjects.

Eligibility criteria:
inclusion criteria: * huntington's disease positive genotype and non-carrier siblings exclusion criteria: * visible chorea * mri contra-indications * major neurological/psychiatric comorbidity
evaluation of some inflammatory markers in autism spectrum disorders

Conditions: Autism Spectrum Disorder

Summary: evaluate some inflammatory markers \[il-6, il-8, tnf_alpha\] in children with autism spectrum disorder

several studies have suggested a correlation between asd and abnormal immune activation (9) for instance, there is a high incidence of autistic subjects in families with other autoimmune disorders such as celiac disease and rheumatoid arthritis, suggesting a potential role for immune dysfunction in the pathophysiology of asd high levels of il-6 in the brain could determine alterations of synapse formation, dendritic spine development, and neuronal circuit balance \[13\], while in plasma they have been associated with increased stereotypical behaviors and with regressive forms of asd

Eligibility criteria:
inclusion criteria: * 50 patients aged 3_18 years, equally sex distributed, who visit pediatric neurology outpatients clinic with autistic disorder at assiut university hospital will enrolled in this study and 50 controls . (according to dsm iv and adt-r) exclusion criteria: * : asperger syndrome, pervasive developmental disorder not otherwise specified (pdd-nos), chronic seizures and recent infection and patients with congenital anomalies
a phase i trial to assess the effects of food and formulation on pk of kpt-330 in patients with sarcoma

Conditions: Sarcoma

Summary: the purpose of this research study is to find out more information such as: to determine the effects of high and low fat foods on the pharmacokinetics (pk) of oral kpt-330 tablets and to compare pk of capsules and tablets in arms 1 and 2; to evaluate tumor response in sarcoma participants in arm 3; to compare the pk of 60 milligrams (mg) of the new, 2nd generation tablet formulation and 60 mg of the selinexor suspension formula to the current, 1st generation tablets.


Eligibility criteria:
inclusion criteria: 1. patients must have histologically confirmed soft tissue or bone/cartilage sarcoma. patients with sarcoma of small round blue cell tumor types are allowed. gastrointestinal stromal tumors (gist) are excluded. 2. patients must have received at least one prior anticancer regimen for metastatic disease unless there is no other therapy available and evidence of progressive disease on study entry. patients with stable disease will be included if there has been failure to respond to another drug(s) within the previous 3 months exclusion criteria: 1. patients with known liver metastases 2. radiation, chemotherapy, immunotherapy, any other systemic anticancer therapy or participation in an investigational anti-cancer study ≤ 3 weeks prior to initiation of therapy 3. patients with known brain metastasis 4. patients with any gastrointestinal dysfunctions that could interfere with the interpretation of the food effect data 5. patients with known intolerance to low or high fat meals 6. in the opinion of the investigator, patients who are significantly below their ideal body weight

Keywords: bone sarcoma soft-tissue sarcoma sarcoma kpt-330 food effects selinexor