Kornimate/medical-research-clean huggingface dataset:
phase ⅱc sutdy of aolanti weikang tablets in fd pds patients

Conditions: Functional Dyspepsia

Summary: the purpose of this study is to evaluate the safety and validity of aolanti weipang tablets in patients with postprandial discomfort syndrome of functional dyspepsia

this is a multi-center, randomized, double blind, placebo-controlled phase ⅱc study to evaluate the safety and validity of aolanti weipang tablets in patients with postprandial discomfort syndrome of functional dyspepsia(fd). this study will consecutive about 12 weeks, including 2 weeks of screening, 1 week of blank run-in, 1 week of placebo run-in, 4 weeks of double blind treatment and 4 weeks of observation after treatment. the subjects will be randomly given orally aolanti weikang tablets or placebo tablets at a 1:1 ratio three times a day(tid) with 3 tablets one time for the treatment.

Eligibility criteria:
inclusion criteria: * patients diagnosed with fd according to the rome ⅳ criteria，and must with symptom of bothersome postprandial fullness; * patients diagnosed with stagnation of qi according to traditional chinese medicine; * at least the symptom of bothersome postprandial fullness ≥4 on the visual analogue scale(vas), and the number of recurrence day must ≥3 in one week; * provides voluntary informed consent after receiving adequate explanation and demonstrates thorough understanding of the nature of the study. exclusion criteria: * the patients with high placebo effect, the scores in placebo run-in stage declined much than 30 percent of the mean vas per week compare to blank run-in stage; * unable to take drugs orally; * within 7 days of screening, the average number of stool \> 2 times/day; * within 7 days of screening, with the presence of ≥ type 5 stool form per the bristol stool form scale; * history of drug or aurantium allergy; * patients with positive in fecal occult blood test; * abnormal liver and/or kidney function: creatinine \>1.5\*uln (upper limits of normal), and/or ast and/or alt \> 2.0\*uln, and/or tbil \> 1.5\*uln; * patients with family history of prolonged qt syndrome or have history of torsional apical ventricular tachycardia; or qtc \> 480 ms; * digestive diseases, or other diseases within 6 months before screening that may affect the swallow, absorption, or metabolism of study drugs, and not yet fully recovered judged by the investigator; * patients who positive in h. pylori test plan to accept the h. pylori eradication therapy within the trial; * serious complications (heart, brain, lung, liver, kidney, or blood disease); * neuropsychiatric disorders; * use of prohibited medications; * pregnant or lactating women or those who are planning to conceive during the study period; * drug abuse within 3 months, or alcohol abuse within 6 months; * patients participated in other clinical trials within 30 days before taking drugs; * other conditions deemed ineligible for enrollment by investigator.
safety and pharmacokinetics study of du-176b administered to patients with severe renal impairment undergoing orthopedic surgery of the lower limbs

Conditions: Venous Thromboembolism

Summary: to assess the safety and pharmacokinetics of du-176b administered to patients with severe renal impairment undergoing orthopedic surgery of the lower limbs, compared with du-176b administered to patients with mild renal impairment (miri) undergoing orthopedic surgery of the lower limbs. for reference, the safety of du-176b in patients with sri undergoing orthopedic surgery of the lower limbs will be compared with that of fondaparinux.


Eligibility criteria:
inclusion criteria: * patients with sri or miri undergoing orthopedic surgery of the lower limbs exclusion criteria: * patients who are on hemodialysis or are scheduled to undergo hemodialysis during the study period * patients who are at a significantly high risk for bleeding or thromboembolism * patients who are receiving another antithrombotic therapy and are unable to suspend the therapy * patients who have evidence of hepatic function test abnormalities

Keywords: anticoagulant du-176b edoxaban factor xa oral orthopedic surgery of lower limbs severe renal impairment
infliximab blood test in crohn's disease

Conditions: Crohn Disease

Summary: ano-perineal lesions are the first signs of crohn's disease in 1/3 to 1/2 of cases. they are most often associated with a poor prognosis of the disease and their management is complex and difficult because of the dilapidated and recurrent nature of lesions with significant repercussions on continence and quality of life. the treatment of these lesions is most often medical and surgical, consisting of drainage of the suppurative lesions and/or the use of biotherapy +/- combined with an immunosuppressant.

pharmacological dosages of biotherapies show a significant correlation between the highest rates and the achievement of clinical and endoscopic remission. therapeutic monitoring by dosing the residual levels of these biotherapies and specific antibodies, particularly in the event of loss of response in order to adapt the treatment, has become common for luminal damage. among these biotherapies, infliximab is the first-line treatment, particularly for ano-perineal disease. effective therapeutic levels are known for luminal damage and must be between 3 and 7 mcg/ml but these levels have not yet been determined for ano-perineal damage. there are only two recently published studies available that suggest levels probably significantly higher than those required for luminal damage ≥ 10 mcg/l

Eligibility criteria:
inclusion criteria: * all patients followed for chron's diseases within groupe hospitalier paris saint-joseph (ghpsj) and treated with infliximab for at least 6 months. exclusion criteria: * all patients with therapeutic compliance problems
hypothalamo-pituitary adrenal axis activity and neuropsychological consequences in type 1 diabetes in childhood

Conditions: Type 1 Diabetes

Summary: the general objective is to precise the role of hpa axis activity in neuropsychological consequences of type 1 diabetes. the investigators hypothesize that hyperactivity of hpa axis is associated with higher scores of depression and changes in hippocampal volume and mean diffusion.

* background: type 1 diabetes could be associated with hyperactivity of hypothalamo-pituitary adrenal (hpa) axis. type 1 diabetes is associated with higher frequency neuropsychological consequences as mood disorders and structural changes in brain, particularly in hippocampus. * purpose: to describe the association between hpa axis activity and anxiety and depression scores in 6-12 year's old diabetes children. * abstract: the general objective is to precise the role of hpa axis activity in neuropsychological consequences of type 1 diabetes. the investigators hypothesize that hyperactivity of hpa axis is associated with higher scores of depression and changes in hippocampal volume and mean diffusion.

Eligibility criteria:
inclusion criteria: * diabetic group: * diabetes for 1 year * 6-12 year's old * included in isis-diab protocol. * control group: * brother or sister of a diabetic children * 6-12 year's old. exclusion criteria: * per os or inhaled corticoid in the previous month of inclusion. * acute infectious disease in the previous week of inclusion. * other chronic disease than diabetes type1. * psychiatric disorders or psychiatric treatment.
i recycle, i protect the environment, i leave a livable world as a legacy

Conditions: Recycling; Behavior Change; Student

Summary: the research will be conducted to determine the effect of "i recycle, i protect the environment, i leave a livable world as a legacy" program on secondary school students' recycling behaviour.

recycling is crucial for environmental health as it plays a significant role in the protection of the environment, the conservation of natural resources, and the reduction of energy consumption. the sustainable development goals (sdgs) are fundamentally centered around the themes of water management, energy sustainability, and responsible consumption and production practices. without proactive measures to safeguard environmental health, the world is likely to encounter significant challenges related to water security, food supply, and the sustainability of natural resources in the future. the study intervention was meticulously formulated on the basis of the planned behaviour theory, encompassing a training programme focused on secondery school students' recycle behaviour. the training program includes topics such as environmental pollution, recycling behaviors, and the protection of natural resources and ecosystems. in addition, the program incorporates activities such as games, puzzle, brainstorming sessions, and the creation of painted cloth bags.

Eligibility criteria:
inclusion criteria: being 10-14 years old and attend the school where the study is being conducted, voluntarily agree to take part in the research, exclusion criteria: having received previous education on environmental health
a pilot study to explore the role of gut flora in acne

Conditions: Acne; Acne Vulgaris; Acne Keloidalis; Acne Keloid; Acne Conglobata; Acne Rosacea; Acne Inversa; Acne Cystic; Acne Pomade; Acne Indurata; Acne Papular; Acne Tropica; Acne Urticata; Acne Fulminans; Acne Follicular; Acne Tropicalis; Acne Detergicans; Acne Iodide; Acne Varioliformis

Summary: this study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.

the goal of this research study is to better understand how the genetic information in subject's microbiome correlates to acne.

Eligibility criteria:
inclusion criteria: 1. signed informed consent, demonstrating that the patient understands the procedures required for the study and the purpose of the study a. may be signed by parent or legal guardian in the case of minor or adult unable to provide consent 2. male or female of all ages. 3. diagnosis of acne by a physician exclusion criteria: 1. refusal to sign informed consent form 2. history of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy. 3. postoperative stoma, ostomy, or ileoanal pouch 4. participation in any experimental drug protocol within the past 12 weeks 5. treatment with total parenteral nutrition
wecareadvisor: a web-based tool to improve quality of life for military veterans with dementia and their caregivers

Conditions: Dementia; Caregiver; Memory Disorders; Alzheimer Disease; Behavioral Symptoms

Summary: this research will test the wecareadvisor tool for family caregivers of military veterans with dementia to help caregivers assess, manage and track behavioral symptoms and their contributing factors (e.g., pain, sleep disturbance), and that provides tailored strategies for in-home, medication-free behavior management. 60 caregiver-person with dementia dyads will be recruited (30 treatment group, 30 wait-list control group).


Eligibility criteria:
inclusion criteria: eligible caregivers must: * be the primary caregiver of a military veteran with dementia for at least 6 months and planning to remain the primary caregiver for the next 2 months * currently living with the person they are caring for (care recipient) * comfortable utilizing technology (e.g. computers, tablets, the internet) * have access to the internet and a computer or tablet device * plans to live in the area for the duration of the study care recipients (military veteran living with dementia) must: * exhibit at least one or more behavioral symptoms (any behavior at any frequency) * receiving psychotropic medication or cognitive enhancers will not exclude the care recipient. * have a clinical diagnosis of dementia (any type) per caregiver report. * be a military veteran. exclusion criteria: * inability to read, speak or understand english * lack of regular access to a telephone, internet, technology (tablet or computer) * caregiver is unable to use a computer or tablet * person with dementia is not a military veteran
care transitions for patients with depression

Conditions: Depression

Summary: aim 1: to collect data on a depression care transition (dct) program's association with self-care behaviors as measured by medication adherence and clinic visit attendance, after discharge. hypothesis 1: compared with usual care, patients who receive the dct intervention will have significantly greater medication adherence and clinic visit attendance, at 30, 90, and 365 days after discharge. aim 2: to collect data on dct's association with clinical/health outcomes as measured by depression severity, functional status, and overall physical and mental health, after discharge. hypothesis 2: compared with usual care, patients who receive the dct intervention will have significantly larger improvements in depression severity, functional status, and overall physical \& mental health at 30, 90, and 365 days after discharge. aim 3: to collect data on dct's association with utilization outcomes as measured by readmissions, length of subsequent hospital stays, and cost of care, after discharge. hypothesis 3: compared with usual care, patients who receive the dct intervention will have significantly lower hospital readmissions, shortened length of subsequent hospital stays and lower cost of care, at 30, 90, and 365 days of discharge. leading the research team are a psychiatrist (dr. ishak - pi) and a hospitalist (dr. nuckols - co-i) with an advanced and well-established track record of health services research/scholarship in the fields of depression, outcome measurement, and economic implications of improving the quality and safety of health care.

this study will contribute to advancing the science of continuity of care delivery for depressed medical inpatients by collecting data on the impact of a modified evidence-based care transition model on clinical/health and utilization outcomes of depression in medically ill inpatients. the study could generate evidence to support the inpatient application of the uspstf guidelines for screening adults for depression through staff-assisted depression care systems including follow-up and continuity of care. this study will add to the existing outpatient evidence for identification and treatment of depression in improving outcomes (simon et al., 2001;o'connor et al., 2013), the crucial aspect of inpatient evidence for depression identification, treatment, and continuity of care/care transitions in improving clinical/health and utilization outcomes.

Eligibility criteria:
inclusion criteria: * participants older than the age of 18, admitted to cedars-sinai medical center, english speaking, and answers "yes" to either question on the phq-2 instrument. exclusion criteria: * participants under the age of 18, non-english speaking, and does not answer "yes" to either question on the phq-2 instrument.
augmented posterior oblique sling activation on lumbopelvic recruitment pattern in lumbosacral radiculopathy

Conditions: Lumbosacral Radiculopathy

Summary: the current study aims to determine the impact of augmented posterior oblique sling activation on lumbopelvic recruitment pattern and functional outcomes in patients with unilateral lumbosacral radiculopathy.

low back pain is now the leading cause of disability worldwide. back pain and its related disability have a huge impact on individuals, communities, and healthcare systems. it reduces an individual's ability to participate in work which in turn negatively affects their quality of life. also, it has major economic consequences through increasing the cost of health care and work absenteeism. among the many differentials of low back pain, the most common cause is lumbosacral radiculopathy. patients with low back pain showed uncontrolled lumbopelvic mobility while performing hip extension movement in functional activities. in patients with back pain, there is over-activation of the hamstrings and erector spinae and delayed or absent contraction of the gluteus maximus. clinically, this pattern is observed as an anterior pelvic tilt with increased extension in the lumbar spine as the patient lifts the leg into extension. so, repetition of this abnormal pattern in patients with lumbosacral radiculopathy may result in mechanical and compressive stresses in the lumbar spine and magnify the patient's symptoms. despite the role of posm in improving spinal mobility and stability. and stabilizing the lumbopelvic joint, there are no previous studies investigating the impact of activation posterior oblique activation on this abnormal lumbopelvic recruitment and functional outcomes in patients with lumbosacral radiculopathy.

Eligibility criteria:
inclusion criteria: * age ranges from 25 to 40 * l4/5 and l5/s1 disc herniation. * duration of pain will be more than three months. * normal body mass index (18.5 - 24.99kg/m2) exclusion criteria: * 1. red flags: spinal tumors, cauda equina syndrome, spinal fractures, osteoporosis, infection. 2. bilateral symptoms. 3. spondylolisthesis, spondylitis, and spinal canal stenosis. 4. previous lumbopelvic or hip surgery or injection 5. any hip structural abnormality such as malformations, impingements and degeneration. 6. postural deviations such as scoliosis, kyphosis, lateral shift. 7. true leg length discrepancy. 8. pregnancy and gynecological problems.

Keywords: posterior oblique sling recruitment pattern lumbar radiculopathy
is the daytime sleepiness based on epworth sleepiness scale a good way to assess taiwanese with suspected obstructive sleep apnea.

Conditions: Obstructive Sleep Apnea

Summary: this observational survey with retrospective follow-up is designed to study the daytime sleepiness based on epworth sleepiness scale a good way or not to assess taiwanese with suspected obstructive sleep apnea.

daytime sleepiness (ds) is a complicated clinical problem, often indicating a serious underlying physiological abnormality and associated with higher prevalence of comorbid conditions such as diabetes, myocardial infarction, and stroke. daytime sleepiness is also the cardinal symptoms of obstructive sleep apnea. how to identify the high risks patients with obstructive sleep apnea for further polysomnography is a difficult problem for doctors in out-patient department. different methods have been proposed for measuring sleepiness and the epworth sleepiness scale (ess) is the measure of sleepiness most commonly used in sleep research and clinical settings. however, whether epworth sleepiness scale is a good tool with high predictive value of obstructive sleep apnea is not evaluated in the population of taiwanese. this observational study is set up to document these practices.

Eligibility criteria:
inclusion criteria: * patients with polysomnography during 2016/1/1-2019/12/31 exclusion criteria: * age under 20 year-old * incomplete polysomnography * incomplete chart information * patients with narcolepsy * patients with previous diagnosed with obstructive sleep apnea, including already patients with obstructive sleep apnea under treatment
epidemiologic assessment of sars-cov-2 (covid-19) prevalence in minnesota

Conditions: Covid19; SARS-CoV Infection; SARS-CoV-2; Corona Virus Infection

Summary: the purpose of this epidemiologic study is to estimate the prevalence and incidence of anti-sars-cov-2 antibodies in at-risk, exposed, affected populations. the study will also estimate the risk of sars-cov-2 exposure in target population.

this study is not for real-time diagnostic purposes, guidance for patient care, or the development of a diagnostic test. the research tests performed for this study will not be prioritized over clinical care samples, that research samples will be batched and tested after clinical care samples. this study is a population-based epidemiologic analysis of prevalence of various groups of persons. group (1) general healthy population. people 18 years of age and older that have not tested positive for sars-cov-2 and who have not sought medical help in the previous 4 months. group (2) medical school residents , 18 years of age and older that have not tested positive for sars-cov-2 group (3) individuals who are hiv positive. people 18 years of age and older that have not tested positive for sars-cov-2

Eligibility criteria:
inclusion criteria: * participants in group 1 (general healthy population) must have no known exposure to sars-cov-2 and have not sought medical help in the previous 4 months for sars-cov-2-related symptoms * participants in group 2 must be currently enrolled in a medical residency program * participants in group 3 must currently test positive for hiv infection exclusion criteria: * presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the participant or the quality of the data (e.g., someone not able to answer the questionnaire because of a psychological condition or an anxiety disorder that is severe). * contraindication for routine blood draws (e.g., severe anemia, hemophilia, etc)
readmission prevention pilot trial in diabetes patients

Conditions: Diabetes Mellitus

Summary: post-discharge hospital utilization, i.e., readmissions within 30 days of discharge (30d readmissions) and emergency department (ed) visits, are a high-priority quality measure and target for cost reduction. patients with diabetes are disproportionately over-represented in 30d readmissions, especially among racial minorities and urban populations. we have developed and validated a tool, the diabetes early readmission risk indicator (derri), to predict 30d readmission risk among diabetes patients, which is a critical prerequisite for targeting limited resources for reducing readmission risk to those most in need. currently, there are no proven interventions to reduce the risk of 30d readmission specifically among patients with diabetes. this proposal will assess the feasibility and acceptability of a novel, multifactorial intervention, the diabetes transition of hospital care program (diatohc), designed to reduce post-discharge hospital utilization rates in a pilot randomized controlled trial. the intervention will include inpatient diabetes and discharge education, comprehensive discharge planning and coordination of care, a1c-based adjustment of diabetes therapy, and post-discharge support. hospitalized patients with diabetes identified as high risk for readmission based on the derri will be randomized to the intervention or the control group, which will receive usual care. such work is highly relevant in the current era of soaring health care costs and national health care reform.


Eligibility criteria:
inclusion criteria: 1. diabetes, defined by pre-admission use of a diabetes-specific medication and/or documentation of the diagnosis in the medical record. exclusion criteria: 1. age \< 18 years at the time of admission 2. female subjects who are pregnant and/or admitted to an obstetric service 3. current or expected admission to a critical care unit 4. binge drinking (5 or more alcoholic drinks for males or 4 or more alcoholic drinks for females on the same day) or drug abuse within 3 months before admission 5. inpatient death 6. transfer to another hospital or subacute facility 7. discharge to hospice or a long-term care facility 8. discharge expected within 12 hours or admission to a short-stay unit 9. lack of access to a phone 10. living more than 30 miles away from temple university hospital (tuh) 11. mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study

Keywords: readmission
study evaluating the safety of lecozotan sr in healthy young and elderly subjects

Conditions: Alzheimer Disease

Summary: to assess the safety, tolerability and pharmacokinetics of single and multiple ascending oral doses of lecozotan sr in healthy young and elderly subjects.


Eligibility criteria:
inclusion criteria: -young subjects: men aged 18 to 45 years. -elderly subjects: men and women ≥ 65 years of age. -body mass index in the range of 18 to 30 kg/m2 and body weight ≥ 50 kg. -healthy as determined by the investigator. exclusion criteria: -history of any neuropsychiatric disorder. -history of drug or alcohol abuse.

Keywords: healthy young volunteers healthy elderly volunteers alzheimer's disease 5ht1a antagonist health pharmacokinetics