Kornimate/medical-research-clean huggingface dataset:
virtual therapy as a method supporting the cardiac rehabilitation

Conditions: Cardiovascular Diseases; Coronary Artery Disease; Depressive Symptoms; Mood Disorders; Anxiety State; Stress

Summary: this study evaluates the effectiveness of virtual reality (vr) therapy in the treatment of depression and anxiety symptoms in patients undergoing second stage of cardiac rehabilitation. half of the study group will receive vr therapy (vr group) as an addition to cardiologically monitored physical training. the other half of the group (control group) will receive schultz autogenic training as a standard supplement to cardiological training.

cardiologically monitored physical training in second stage of cardiac rehabilitation leads to the improvement in the physical capacity and overall fitness of the patients with coronary artery disease, allowing restoration of independence in daily functioning. psychological support is required in order to reduce the negative psychological symptoms related to both the heart disease itself and the cardiac surgery performed. in this study the investigators want to assess the effectiveness of the virtual reality (vr) therapy compared to standard psychological support (schultz autogenic training). thanks to using head mounted display and the phenomenon of total immersion vr therapy allows to completely separate the patient from the hospital environment, provides an intense visual, auditory and kinesthetic stimulation. depending on the stage of therapy it can have a calming and mood-improving effect or, in another part of the therapy, it can motivate the patient to the rehabilitation process. the additional aim of the vr therapy is to help the patients regain their emotional balance, let them recognize their psychological resources and trigger the natural recovery mechanisms. the goals of the project: 1. the evaluation of the influence of vr therapy on the depressive symptoms and the anxiety level of the patients undergoing second stage of cardiac rehabilitation. 2. the evaluation of the influence of vr therapy on the stress level of the patients undergoing second stage of cardiac rehabilitation.

Eligibility criteria:
inclusion criteria: * coronary artery disease; * the second stage of cardiac rehabilitation conducted in outpatient settings; * anxiety symptoms scored 8 and more in hads-a or depressive symptoms scored 8 and more in hads-d. exclusion criteria: * cognitive impairment (mmse\<24); * inability to self-complete the research questionnaires; * presence of the following issues at the time of the examination or in the medical data: disturbances of consciousness, psychotic symptoms or other serious psychiatric disorders; * initiation of psychiatric treatment during the research project; * contraindications for virtual therapy (epilepsy, vertigo, eyesight impairment); * the patient's refusal at any stage of the research project.

Keywords: virtual reality cardiac rehabilitation psychotherapy cardiac surgery depression anxiety stress elderly coronary artery disease ischemic heart disease
study evaluating the efficacy and safety of flexible-dose vardenafil in subjects with erectile dysfunction

Conditions: Erectile Dysfunction

Summary: study to investigate the efficacy and safety of vardenafil


Eligibility criteria:
inclusion criteria: * men \>/= 18 years of age, with 6 months or longer diagnosis of ed as defined by nih consensus statement, * history of unresponsiveness to sildenafil * stable sexual relationship for \> 6 month. exclusion criteria: * primary hypoactive sexual desire * history of myocardial infarction, stroke or life-threatening arrhythmia within prior 6 month * nitrate therapy * other exclusion criteria apply according to the us product information

Keywords: erectile dysfunction vardenafil
a retrospective review of infections usually observed in transplant recipients

Conditions: Infection

Summary: the study will identify patients with infections commonly observed in transplant recipients, describe the epidemiology of their infection, study the risk factors associated with various infections and examine strategies of early diagnosis and prevention of infection

the following variables will be followed: time and location of positive cultures, underlying diseases and severity of illness, recent immunomodulative therapies, physical exam findings, previous medical surgical conditions, microbiology and virology culture results, laboratory and radiographical data, antimicrobial usage of onset of infection, microbiological data and resistance patterns, choice of antibiotics once organism identified, suspected source of infection, bacteriological outcomes, laboratory results, demographic information, pathology and histology results, summaries of admissions, discharges, operations, death, medications, clinical outcome gender, height, weight, ethnicity, date of transplant, type of transplant, primary diagnosis, and past medical history. also required are medical summaries of admissions, discharges, operations, and deaths

Eligibility criteria:
inclusion criteria: * patients who receive medical care at upmc * patients who developed infections usually observed in transplant recipients exclusion: * patients who do not receive medical care in upmc oakland campus

Keywords: infection transplant recipients
comparing two pneumococcal vaccines in adults with chronic obstructive pulmonary disease

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: pneumococcal disease is a serious bacterial infection that can affect different parts of the body, including the lungs. people with chronic illnesses, such as chronic obstructive pulmonary disease (copd), have a greater risk of developing pneumonia and meningitis as a result of pneumococcal disease. this study will compare the immune response to two types of pneumococcal vaccines in adults with copd.

individuals who are infected with the streptococcus pneumoniae bacteria may develop pneumococcal disease, a serious disease that kills more people in the united states than all other vaccine-preventable diseases combined. individuals with copd, characterized by breathing difficulties due to damaged and obstructed lung airways, may have an increased risk of developing serious complications from pneumococcal disease, including pneumonia and meningitis. currently, there are two types of pneumococcal vaccines available. the pneumococcal capsular polysaccharide (cps) vaccine, known as pneumovax, is typically given to adults 65 years of age or older and to any individuals with a serious health condition, including heart disease, lung disease, and diabetes. the diphtheria protein-conjugated vaccine (pcv7), known as prevnar, is typically given to infants; however, adults who receive this vaccine may also have a favorable response. the purpose of this study is to compare the immune response to the pneumovax and prevnar vaccines in adults with copd. this study will enroll adults with mild to moderate copd. participants will be randomly assigned to receive either the pneumovax or prevnar vaccine. this will involve one or two injections. blood collection will occur during study visits at months 1, 12, and 24. study researchers will contact participants by telephone at months 6 and 18 to document any pneumococcal infections and any additional pneumococcal vaccinations.

Eligibility criteria:
inclusion criteria: * diagnosis of chronic obstructive pulmonary disease (copd) * post-bronchodilator forced expiratory volume at one second /forced vital capacity (fev1/fvc) level less than 70% * ten or more pack-years of smoking * willing to make return visits to the study clinic and accept telephone contact * last pneumococcal vaccination occured at least 5 years prior to study entry exclusion criteria: * asthma * sensitivity to pneumococcal vaccine * known bleeding disorder, or requires long-term anticoagulation therapy * presence of chronic disease that may impair pneumococcal vaccine response * acute illness requiring antibiotics in the month prior to study entry * medical condition that makes survival for 24 months following study entry unlikely * pregnant

Keywords: chronic obstructive pulmonary disease copd pneumococcal vaccine opsonization antibodies
the chinese pulmonary lymphoepithelioma-like carcinoma collaboration study

Conditions: Primary Pulmonary Lymphoepithelioma-like Carcinoma

Summary: this retrospective case-control study aims to investigate the genetic mechanisms of primary pulmonary lymphoepithelioma-like carcinoma, identify genetic susceptibility loci associated with its onset, and explore potential pathogenic genes, providing new insights for its etiological research.

pulmonary lymphoepithelioma-like carcinoma (plelc) is a rare non-small cell lung cancer (nsclc) that histologically resembles nasopharyngeal carcinoma (npc) and predominantly affects the asian population. epstein-barr virus (ebv) infection is a recognized pathogenic factor, and the regional prevalence of plelc suggests that genetic susceptibility also plays an important role. however, no genetic studies on plelc have been conducted, leaving its genetic etiology poorly understood. in this study, genotyping for all the subjects was performed by using illumina infinium global screening array. genome-wide association followed by meta-analysis was performed for plelc cases and healthy controls. the primary objective of this study is to discover susceptibility genes that explain the genetic mechanisms of plelc.

Eligibility criteria:
case: inclusion criteria: the subject is pathologically diagnosed with primary pulmonary lymphoepithelioma-like carcinoma. exclusion criteria: the subject is diagnosed with metastatic nasopharyngeal carcinoma; the subject has heavy cardiovascular, liver, or kidney disease. controls: inclusion criteria: the subject is in good physical condition and has a stable level of consciousness; exclusion criteria: the subject has prevalent cancer; the subject has heavy cardiovascular, liver, or kidney disease.

Keywords: genome-wide association study primary pulmonary lymphoepithelioma-like carcinoma
multi-morbidity screening in people with type 2 diabetes and pre diabetes

Conditions: Type 2 Diabetes; Pre Diabetes; Obstructive Sleep Apnea; Non-Alcoholic Fatty Liver Disease; Heart Failure

Summary: people with type 2 diabetes are at risk of complications linked with high blood sugars and these are monitored for in healthcare appointments. however, people with type 2 diabetes commonly suffer with additional health conditions that can affect the liver, heart and their breathing while sleeping. these conditions are thought to be caused by a similar underlying process that causes type 2 diabetes, as a result they are very common in people type 2 diabetes. despite this they are not part of the routine health check for these people. worryingly, current research suggests that the risk for developing these health problems, and direct complications of type 2 diabetes, can start at blood sugar levels below the threshold of type 2 diabetes. in a group of people said to have prediabetes. these people do not currently undergo annual healthcare appointments to monitor for these health complications or other linked health conditions. this study aims to pilot a new style of clinic to address these issues. the investigators will perform a multi-morbidity assessment, where they will look for several different health problems at the same time. the investigators will be looking at health problems linked with high blood sugars, this will include problems with the liver, heart, nerves, eyes, and participants breathing overnight. they have developed a clinic visit which uses questionnaires, simple examination techniques and modern devices to try and identify these health problems. an important part of healthcare is the burden it places on people with health problems, with this in mind the investigators will be giving the people involved in their study a voice to try and direct future research and healthcare, the investigators will ask them to provide feedback on their experience in taking part in the study and what their thoughts are in undergoing a longer but more comprehensive health appointment.


Eligibility criteria:
inclusion criteria: type 2 diabetes study group * participants with a documented diagnosis of type 2 diabetes or hba1c ≥48mmol/mol. * age ≥18 years prediabetes study group * hba1c 42 - 47 mmol/mol (inclusive) or enrolled in the diabetes prevention programme. * age ≥18 years exclusion criteria: * type 1, 3 or maturity onset diabetes of the young. * participants who are pregnant at the time of screening * unable to give informed consent

Keywords: screening multi-morbidity
mental health in austrian teenagers (mhat)

Conditions: Mental Disorders

Summary: the purpose of the mental health in austrian teenagers (mhat) - study is to collect the first epidemiological data on mental health and psychiatric disorders in a representative sample of austrian adolescents between 10 and 18 years.

knowing about the prevalence of psychiatric disorders and related risk and protective factors is essential for the development of prevention programs and therapeutic approaches. up to now, no epidemiological data on prevalence rates of psychiatric disorders and related risk and protective factors based on a representative sample is available for austrian adolescents. the aim of the study is to present rates of behavioral, emotional and social problems as well as prevalence rates of mental disorders. furthermore the investigators want to examine risk factors, protective factors and quality of life in a large sample of adolescents aged 10 to 18 years. a two step design is chosen for this purpose to obtain diagnoses based on the diagnostic and statistical manual of the american psychiatric association, version 5 (dsm-5): 1. phase 1 (screening) is a screening for emotional, behavioral and social problems as well as social and demographic correlates, risk and protective factors and quality of life. 2. phase 2 (interviews) includes structured diagnostic interviews to assess psychiatric diagnoses according to dsm-5 criteria with adolescents above a predefined cut-off score in the screening, and a random sample of adolescents scoring below the cut-off.

Eligibility criteria:
inclusion criteria: * adolescents aged 10-18 exclusion criteria: * no written informed consent possible due to intelligence or no willingness by parents to include minor

Keywords: children and adolescents mental health epidemiology psychiatric disorders
effect of consumption of caraway on treatment of obesity

Conditions: Obesity; Overweight

Summary: this study aims to investigate the applicability of caraway (black cumin) intake on the treatment of obesity. so, a randomized placebo controlled clinical trial will be conducted to examine the applicability of caraway product in terms of safety and efficacy.

a randomized placebo-controlled clinical trial, was done on 120 healthy overweight and obese women aged 20-55 in iran. data were collected trough questionaires, interview and physical examination. the required parameters including anthropometric indices, body composition vital parameters (heart rate and blood pressure)and full blood parameters, were measured before and after intervention. volunteers were randomized into test and control group and were asked to consume either caraway samples or placebo during 12 intervention weeks. the outcome measure will be assessed for both primary and secondary data from baseline through week 12 (3 months).

Eligibility criteria:
inclusion criteria: * overweight and obese women (bmi\> 25) * aged 20-55 years old * healthy subjects exclusion criteria: * pregnant and lactating women * thyroid disease * type i or ii diabetes mellitus * hypertension (systolic bp 140 and/or diastolic bp 90) * endocrine dysfunction * impaired liver function * chronic renal disease * cardiovascular disease * primary dyslipidemia * myopathy * patients using drugs which affect on metabolism or appetite * a maintained weight loss in the preceding 3 months * meals not eaten at regular intervals * participation in another investigation study within the past 30 days * a history of alcohol or drug abuse within the past year * smoking * a history of sleep disorders * clinical depression or other psychiatric conditions * abnormal obese * allergy or sensitivity to any of the 'active' or 'placebo' product ingredients

Keywords: obesity overweight bmi
treatment strategy for low-grade gliomas

Conditions: Astrocytomas; Oligodendrogliomas; Oligoastrocytoma

Summary: although the prognosis of patients with low-grade glioma (lgg) is generally good, recurrence seems unavoidable in some patients because of the infiltrative growth of the tumors. how to treat lggs is still under controversy. the role of radiation therapy and chemotherapy in the treatment of lgg need to be further investigated. the purpose of this study is the following: 1. to investigate the role of early radiation therapy in mri-determined total resected lggs; 2. to compare the efficacy of early radiation therapy and that of initial chemotherapy in the lggs without total resection.


Eligibility criteria:
inclusion criteria: * histologically confirmed newly diagnosed low-grade gliomas * karnofsky performance status of 60 or more exclusion criteria: * previous history of radiation therapy or chemotherapy for gliomas * pregnant or breast feeding * diagnosis of another malignancy may exclude subject from study * evidence or history of bleeding diathesis * evidence or history of hypersensitivity to temozolomide
efficiency study for acute radiation-induced and chemotherapy-induced pulmonary fibrosis with bevasizumab

Conditions: Pulmonary Fibrosis

Summary: due to the radiosensitivity of the lung, radiation-induced and chemotherapy-induced pneumonitis and pulmonary fibrosis are frequent happened following cancer therapy. it not only compromise cancer treatment, but also influence patient's life qualities and even death. there are no specific treatment modalities for this treatment-induced complication. bevasizumab (avastin), a vegf inhibitor, can attenuate serum high expression vegf and pulmonary permeability, maybe effective in the control acute pulmonary fibrosis. patients will be randomized to receive bevasizumab (7mg/kg iv) on day one and 21, followed by dexamethasone （10mg iv d 1-10, then 5mg iv d11-15, 2.5mg iv d16-20) or dexamethasone alone. the thoracic ct, plasma tnf-a, il-6, vegf and c-reactive protein are accessed on before treatment, 24 hours after bevasizumab, 7 days, 4 and 8 weeks. the target sample size is 30 cases.


Eligibility criteria:
inclusion criteria: * clinical diagnosed cancer treatment-induced acute pulmonary fibrosis exclusion criteria: * chronic pulmonary fibrosis and infection-induced pulmonary fibrosis * active bleeding * uncontrolled high blood pressure * unstable systemic disease * prior exposure to vegf inhibitor

Keywords: becacizumab pulmonary fibrosis irradiation chemotherapy
muscle energy technique and facet joint mobilization in chronic neck pain.

Conditions: Chronic Neck Pain

Summary: the purpose of the study is to compare the muscle energy technique, facet joint mobilization and conventional physical therapy in individuals with chronic neck pain on cervical lordosis, cervical range of motions, numeric pain rating scale and ndi. a randomized control trial was conducted at physiotherapy department of hit hospital, taxila cantt. the sample size was 105 calculated through open-epi tool. the participants were divided into three interventional groups, experimental group (1), experimental group (2), and control group (3) each having 35 participants. the study duration was six months. sampling technique applied was purposive sampling for recruitment and group randomization using sealed envelope method. only 35 to 50 years participants with 4-8 pain intensity on nprs in cervical region were included in the study. goniometer, posterior tangent method on lateral radiographs for cervical curve and self structured questionnaire. data was collected at baseline then 2 and 4 weeks after the application of interventions. data analyzed through spss version 21.


Eligibility criteria:
inclusion criteria: * chronic patients (more than 12 weeks) * male and female patients * patients having recurrence of neck pain at least once in the last month. * patients from the age group of 35-50 years. * patients having mechanical neck pain ranging from 4-8 on numeric pain rating scale (nprs). * cervical straightening on x-rays. * limited \&painful cervical rang of motion (roms) exclusion criteria: * any recent history of trauma, active inflammation, tumor, vertebra-basilar insufficiency and cervical myelopathy \& radiculopathy. * no history of serious underlying pathology, nerve root compromise, structural changes and deformities, genetic spinal disorders or previous spinal surgery

Keywords: cervical pain chronic neck pain, muscle energy technique, facet join mobilization, cervical lordosis, cervical curve
reducing parental stress via instant messaging during covid-19 pandemic: a randomized controlled trial

Conditions: Parents; Parenting; Stress

Summary: this research investigated the effects of mindfulness practice on mental wellbeing and parenting behaviour, with the instruction recordings delivered via existing instant messaging applications, including whatsapp and signal. the two-week mindfulness program targeted parents with children in nursery, kindergarten to primary school. due to the suspension of schools, work from home policies, parents spend increased amount of time with their children. news reports have indicated that with the mounting care taking responsibilities and downturn of economy amidst the epidemic, parents have been experiencing higher stress that may negatively impact their wellbeing and parent-child relationship. this study delivered an app-based intervention that aims at enhancing mindful parenting at the time of corona, where social distancing is emphasized.


Eligibility criteria:
inclusion criteria: parents with at least one child who is in primary school or below.
delayed nausea and vomiting in patients with colorectal cancer receiving oxaliplatin

Conditions: Colorectal Cancer; Nausea; Vomiting

Summary: rationale: learning how often patients experience nausea and vomiting after receiving anti-vomiting medicine and chemotherapy for colorectal cancer may help doctors plan better treatment and improve patients' quality of life. purpose: this clinical trial is studying delayed nausea and vomiting in patients with colorectal cancer receiving standard anti-vomiting medicine during the first course of chemotherapy.

objectives: * to assess the prevalence of delayed nausea and vomiting in patients with colorectal cancer receiving standard anti-emetic medications during the first course of an oxaliplatin-based chemotherapy regimen (mfolfox6 or folfox7). outline: this is a multicenter study. patients undergo collection of demographic, diagnostic, and treatment data at baseline. patients complete the functional living index-emesis (flie) questionnaire at baseline prior to first chemotherapy infusion and at 5-7 days. patients also fill out daily patient diaries about symptoms of nausea and vomiting, and use of medications to prevent these symptoms over days 1-5.

Eligibility criteria:
disease characteristics: * diagnosis of colorectal cancer * currently receiving or scheduled to receive the first course of either of the following chemotherapy regimens: * mfolfox6 * folfox7 * no clinical or imaging evidence of brain metastasis patient characteristics: * able to maintain a diary and complete a standardized quality of life questionnaire in english prior concurrent therapy: * see disease characteristics * more than 90 days since prior aprepitant

Keywords: nausea and vomiting colon cancer rectal cancer