Kornimate/medical-research-clean huggingface dataset:
the chaps trial: combined hiv adolescent prep and prevention

Conditions: HIV/AIDS

Summary: to compare the effect of different prep drugs (ftc-tdf and ftc-taf), doses and timing of doses on p24 antigen level in resected foreskin tissue following hiv exposure ex vivo challenge.

1. investigate the timing and dose of ftc-tdf and ftc-taf as oral prep and in vitro pep (applied directly to removed foreskin tissue) required to prevent ex vivo hiv infection in foreskin tissue and blood using the explant model 2. determine blood, rectal fluid and foreskin tissue concentrations of ftc, tfv, taf and their active metabolites that are required for ex vivo hiv protection 3. evaluate inflammation, cellular activation, foreskin mucosal integrity, gene expression and microbiome in foreskin tissue following oral in vivo prep and in vitro pep 4. evaluate the efficacy of in vitro post exposure dosing with prep in protection against ex vivo hiv infection using the explant model 5. to investigate sexual behaviour, prep acceptability and feedback on hiv prevention trials implementation

Eligibility criteria:
inclusion criteria: participants must satisfy all the following criteria within 21 days prior to their circumcision visit: 1. clinically eligible for either forceps guided, or dorsal slit circumcision 2. the ability to understand and sign a written informed consent form by participant (and participant's legal guardian if younger than 18 years) prior to participation in any study procedures and to comply with all trial requirements 3. male sex at birth 4. age 13- 24 years 5. haemoglobin \>9g/dl 6. weight \>35kg 7. two negative rapid hiv antibody tests results (manufactured by different companies), dating from 21 days or less prior to vmmc 8. two locator information details (including physical address, telephone contacts, email) for contacting of either patient or their parent exclusion criteria: 1. any significant acute or chronic medical illness and current therapy that in the opinion of the site investigator would preclude receipt either of investigational products, or vmmc 2. any evidence that participant is not suitable for vmmc

Keywords: pre-exposure prophylaxis
high-flow nasal cannula and exercise tolerance in copd

Conditions: COPD; Rehabilitation; Exercise

Summary: patients with copd are often unable to sustain a sufficient workload during exercise. the use of external strategies to improve exercise tolerance, such as non-invasive ventilation (niv) and high-flow nasal therapy (hfnt) have been used. the objective was to evaluate and compare the acute effects of hfnt and niv during exercise on cardiorespiratory parameters, dyspnea, exercise tolerance and comfort in patients with moderate to severe copd.

the patients underwent an initial clinical examination, with anthropometric evaluation, blood gas analysis, pulmonary function tests and measurement of maximum respiratory pressures. the exercise protocol started in the sector of ergometry and cardiopulmonary exercise testing. after completing the maximum incremental cardiopulmonary exercise test, two additional visits were scheduled for the three constant load tests. all patients studied underwent an evaluation of cardiopulmonary exercise testing (cpet). during maximum-incremental cpet, breath by breath: oxygen consumption (v̇o2, ml/min), carbon dioxide production (v̇co2, ml/min), respiratory exchange rate (rer), minute ventilation ve (l/min), respiratory rate (bpm), equivalent ventilation for o2 and co2 (v̇e/v̇o2 and v̇e/v̇co2). in addition, cardiac monitoring was performed by 12-lead electrocardiogram (ecg) throughout the procedure. on the day of the experiment, the patients underwent two cardiopulmonary exercises with constant-load at 90% of the previously determined peak, separated by an interval of at least 1 hour. the niv parameters were adjusted for each patient with trilogy 100 (philips™). spontaneous ventilation mode was set before the protocol for all patients, and a previous period of niv adaptation was performed to titrate the inspiratory and expiratory pressures. the adaptation period started with the minimum inspiratory positive airway pressure (ipap) value of 15cmh2o, and, every 2 minutes, increasing the pressure every 2 cmh2o according to the patient's tolerance.16 the expiratory positive airway pressure (epap) was programmed to vary between 4 and 6 cmh2o. before the start of the examination, an adaptation was performed with the selected mask and initial ventilator settings for 20 min. no additional oxygen was offered. the high flow system used was optiflow® (fisher \& paykel healthcare, auckland, new zealand). before the test, flow titration was performed for the patient, which started with the administration of a minimum gas flow of 30l/min and, every 2 minutes, the flow was increased by 5l/min according to patient tolerance. the test only started after 20 minutes of adaptation.

Eligibility criteria:
inclusion criteria: * previous copd * fev1 ≤ 50% * optimized medication exclusion criteria: * copd exacerbation * cardiac disease * previous neurologic disorders * unable to complete all protocol

Keywords: copd high flow nasal therapy non-invasive ventilation
lenalidomide and sintilimab for relapsed/refractory nk/t-cell lymphoma

Conditions: NK/T Cell Lymphoma Nos

Summary: the purpose of this study is to evaluate the efficacy and safety of sintilimab in combination with lenalidomide in the treatment of relapsed/refractory nk/t-cell lymphoma patients who failed pegaspargase-based regimens.

pegaspargase is the backbone of treatment for nk/t-cell lymphoma (enktcl), and patients with enktcl who failed pegaspargase-based regimens have extremely poor survival outcomes. previous study has confirmed the efficacy of anti-pd-1 antibodies (including pembrolizumab or sintilimab). constitutive activation of nf-kb pathway has been demonstrated to be involved in the development of enktcl and plays critical role in therapy resistance. lenalidomide, an immuno-modulatory drug, has been found to inhibit nf-kb pathway, and synergize with anti-pd-1 antibody in the treatment of multiple myeloma. thus, we hypothesize that the combination of lenalidomide and sintilimab will further deepen the remission status and benefit patients who failed pegaspargase-based regimens.

Eligibility criteria:
inclusion criteria: * histopathology and immunohistochemistry confirmed diagnosis of nk/t-cell lymphoma according to who 2016 criteria. * previously treated with pegaspargase-based regimens (refractory or relapsed after initial remission). * pet/ct or ct/mri with at least one objectively evaluable lesion. * general status ecog score 0-3 points. * the laboratory test within 1 week before enrollment meets the following conditions: blood routine: hb\>80g/l, plt\>50×10（9）/l. liver function: alt, ast, tbil ≤ 2 times the upper limit of normal. renal function: cr is normal. coagulation : plasma fibrinogen ≥ 1.0g / l. cardiac function: lvef≥50%, ecg does not suggest any acute myocardial infarction, arrhythmia or atrioventricular conduction above i blocking. * sign the informed consent form. * voluntary compliance with research protocols, follow-up plans, laboratory and auxiliary examinations. exclusion criteria: * patients with a history of pancreatitis. * active infection requires icu treatment. * concomitant hiv infection or active infection with hbv, hcv. patients who are infected with hbv but not active hepatitis at the same time are not excluded. * serious complications such as fulminant dic. * significant organ dysfunction: such as respiratory failure, nyha classification ≥ 2 chronic congestive heart failure, decompensation hepatic or renal insufficiency, high blood pressure and diabetes that cannot be controlled despite active treatment, and cerebral vascular thrombosis or hemorrhagic time within the past 6 months. * pregnant and lactating women. * had a history of autoimmune diseases, and disease was active in the last 6 months, and was still taking oral immunosuppression in the past three months. * those who were known to be allergic to drugs in the study regimen. * patients with other tumors who require surgery or chemotherapy within 6 months. * other experimental drugs are being used.

Keywords: pegaspargase sintilimab pd-1 lenalidomide relapsed/refractory
liquid bandage (2-octyl-cyanoacrylate) in upper lid blepharoplasty

Conditions: Blepharoptosis

Summary: the aim of this randomized and masked prospective trial is to compare the effectiveness of liquid bandage (octyl-2-cyanoacrylate) and 6/0 nylon suture as a wound closure device in upper lid blepharoplasty surgery.

tissue adhesives have been safely used in a variety of surgical procedures for several years. butyl-2-cyanoacrylate (histoacryl) and octyl-2-cyanoacrylate (dermabond) was also studied for cosmetic blepharoplasty with satisfactory results. liquid bandage (johnson \& johnson, skillman, nj, usa) is a more flexible formulation of octyl-2-cyanoacrylate available in many american drugstores for home use. animal models shown that this product could accelerate the healing of lamellar wounds and studies in humans have demonstrated its safety and effectiveness as an occlusive protective film over cuts, abrasion and wound surgery. liquid bandage was also used as a temporary wound barrier in clear corneal cataract surgery with satisfactory applicability. there is no study in the literature using this device in blepharoplasty yet.

Eligibility criteria:
inclusion criteria: * patients older than 25 years with diagnosis of dermatochalasis who presented surgical indication of primary blepharoplasty. exclusion criteria: * prior eyelid surgery * concomitant ocular or systemic disease or current use of medications that could interfere in coagulation or wound healing (eg, diabetes mellitus, oral acetyl salicylic acid or corticosteroids) * pregnant female * known allergy to cyanoacrylate * inability to return for follow-up consultations

Keywords: blepharoptosis dermatochalasis octyl 2-cyanoacrylate suture techniques tissue adhesive
hydronephrosis after anterior lumbar interbody fusion (alif)

Conditions: Hydronephrosis

Summary: anterior lumbar spinal surgery involves making an incision through the abdomen of the patient in order to access the spine. during this process, several internal structures are pushed aside in order to gain access. one of these structures is the ureter, whose function is to drain urine from the kidney to the bladder. one potential complication that can arise from this is dilation of the kidney - known as hydronephrosis. the aim of this study is to identify whether hydronephrosis after anterior lumbar interbody fusion (alif) is complication, in order to bring this to the attention of health care professionals when considering this kind of surgery.

a total of 40 patients who have had alif surgery will be invited to have an ultrasound scan of their kidney on the side where the operation was performed (where the scar is). should hydronephrosis of this kidney be detected, the investigators will go on to scan the second kidney. should hydronephrosis be detected the patient will be given a letter to take to their general practitioner (gp) advising them to be referred to a urologist.

Eligibility criteria:
inclusion criteria: * over 18 years of age * has the mental capacity to provide informed consent for participation within the study * patients who have had anterior lumbar spinal surgery at least 12 months ago and no longer than 5 years ago exclusion criteria: * unable to understand written or verbal information regarding the study * multiple abdominal surgeries prior to spinal surgery * previous renal complication such as renal strictures or hydronephrosis/use of stents * pregnancy * structural anomalies

Keywords: hydronephrosis anterior lumbar interbody fusion
clinical evaluation of hydrogels vs silicone hydrogel contact lenses

Conditions: Myopia

Summary: the aim of this fitting study is to evaluate the clinical performance of different hydrogel and silicone hydrogel contact lenses.

this is a 20-subject, double masked, randomized, contra lateral, 2-day non-dispensing fitting trial.

Eligibility criteria:
inclusion criteria: a person is eligible for inclusion in the study if he/she: * is between 18 and 40 years of age (inclusive) * has had a self-reported visual exam in the last two years * is an adapted soft contact lens wearer * has a cl spherical prescription between -1.00 and -6.00 (inclusive) * has a spectacle cylinder up to 0.75d (diopter) in each eye * is correctable to a visual acuity of 20/25 or better in both eyes * has clear corneas and no active ocular disease * has read, understood and signed the information consent letter * is willing to comply with the wear schedule * is willing to comply with the visit schedule exclusion criteria: a person will be excluded from the study if he/she: * has never worn contact lenses before * currently wears rigid gas permeable contact lenses * has a history of not achieving comfortable contact lens wear (5 days per week; \> 8 hours/day) * has a contact lens prescription outside the range of -1.00 to -6.00d * has a spectacle cylinder ≥ 1.00d of cylinder in either eye * has best corrected spectacle distance vision worse than 20/25 in either eye * has any systemic or topical medications that will affect ocular health * has any ocular pathology or severe insufficiency of lacrimal secretion * has persistent, clinically significant corneal or conjunctival staining * has active neovascularization or any central corneal scars * is aphakic * is presbyopic * has undergone corneal refractive surgery * is participating in any other type of eye related conical or research study
sphenopalatine ganglion block in septorhinoplasty

Conditions: Pain, Postoperative; Rhinoplasty

Summary: septorhinoplasty is a widely performed surgery that aims to correct both functional and aesthetic problems of the nose. despite its expected clinical benefits, septorhinoplasty surgery causes postoperative pain, which affects the patient's functional recovery and satisfaction. opioids, non-steroidal anti-inflammatory drugs (nsaii), acetaminophen and local anesthetics are used in peroperative pain management in septorhinoplasty. sphenopalatine ganglion block (spgb), which has been recently described and has different application areas, is a regional analgesia technique that has been investigated for this purpose. although there are studies on postoperative pain in septorhinoplasty surgeries, there are not enough studies on its effects on intraoperative pain. this study may have positive effects on appropriate pain management, patient comfort and surgical outcomes as multimodal analgesia management in septorhinoplasty surgeries, and may make significant contributions to evidence-based practices.


Eligibility criteria:
inclusion criteria: * undergoing septorhinoplasty surgery * ages between 18-65 * asa (american society of anesthesiologists) score i-ii exclusion criteria: * unavailable postoperative pain scores and analgesic use in the hospital registry system * local anesthetic drug allergy and toxicity * advanced organ failure * mental retardation patients who are pregnant
the effects of short-foot exercises in foot posture

Conditions: Pronation Deformity of the Foot

Summary: therefore, the aim of this study is to examine the effects of the short foot exercises compared to placebo exercises in the foot posture index after a daily period of 4 weeks.

the intrinsic foot muscles collaborate in maintain the media longitudinal arch and in the postural control of the body.1 the plantar intrinsic foot muscles play a crucial role providing the foot stability and flexibility. 2 there are few studies about the relationship between hyperpronation and the training of the intrinsic muscles. a specific training program as a "short foot exercise" (sfe) may improve pathological conditions involving the foot and the lower extremity including plantar fasciitis, tendinopathies and foot hiperpronation.3 several balance training techniques have been applied for improving postural stability, and the sfe have been widely accepted by physiotherapists to improve the longitudinal arch foot and the body segments.4 in this study, the foot posture will be evaluated with the foot posture index (fpi) and the navicular drop test (ndt). the foot posture index is a validated and useful method like a complementary tool for evaluating foot disorders. 5. the foot posture quantify the foot posture as normal, pronated or supinated. the foot posture index indicates a pronated foot position in a support relaxed position when ipp is equal to or superior to a +6 value. 5 the navicular drop test quantifies, in millimeters, the descent of the navicular tuberosity. it was developed to evaluate the pronation of the foot and, consequently, the drop of the medial longitudinal arch, a excessively pronated foot (ndt≥10mm).6. therefore, the aim of this study is to examine the effects of the sfe compared to a placebo exercise in the foot posture index after a daily period of 4 weeks. there is a lack of evidence of the effect of training intrinsic muscles in foot posture. the hypothesis of the researches is that the sfe may contribute to improving the pronated foot posture. this treatment may allow normalizing the foot posture and the kinematic interaction of the lower extremity joints during walking.

Eligibility criteria:
inclusion criteria: males and females between 18 and 65 years old. - exclusion criteria: * the exclusion criteria: serious illness, current participation in another research study, pregnancy, previous foot surgery, current treatment of foot pathology.

Keywords: pronation
chondux for filling full thickness cartilage defects in the femoral condyle of the knee

Conditions: Cartilage Defect

Summary: the use of chondux cartilage repair system for the treatment of single cartilage lesions in the femoral condyle of the knee. the primary outcome measure is degree of lesion fill at 6 months. filling of the femoral chondral defect of the knee using chondux™ cartilage system may give symptomatic relief of pain and help to restore knee function. included in this study is pain relief using visual analog scale (vas), knee function using the international knee documentation committee (ikdc) questionnaire and quality of life using the short form-36 (sf-36) survey.

current treatment approaches for articular cartilage defects have been disappointing and clinical results have been variable. however, when using crosslinked hydrogel technologies, in vitro findings have shown chondrocyte growth and extra-cellular matrix (ecm) production supportive of cartilage production.

Eligibility criteria:
inclusion criteria: * a standing radiograph of the knee showing a kellgren score of 0-2 * body mass index ≤33 * an outerbridge score of iii or iv without need for bone graft * a meniscus with no more than partial resection in the affected knee exclusion criteria: * passive motion deficit of the knee (\>5º of extension, \>15º of flexion) * moderate or severe osteoarthritis * diabetes mellitus (iddm type 1) * patellofemoral instability * malalignment with \> 5° valgus or varus compared to contralateral knee * active osteomyelitis

Keywords: articular cartilage microfracture knee pain cartilage repair subjects with an articular cartilage defect in the knee.
comparison of upper extremity and lower extremity function and quick dash

Conditions: Hand Injuries

Summary: patient reported outcome measure (prom) are a method by which to assess outcomes from a patient perspective. the quickdash is a commonly used prom. qdash was validated against grip strength and ability work, however not against its ability to actually measure what it sets forth to measure (ie: patient's ability to use a hammer, carry a shopping bag, wash a wall, etc). the purpose of this study is to correlate the self-reported qdash with patients' ability to perform the functions on the qdash and compare to a control group who completes the task on a lower extremity prom, koos jr.


Eligibility criteria:
inclusion criteria: * new patient * stanford hand surgery clinic patient exclusion criteria: -
predictive utility and mechanisms of sacral evoked responses in sacral neuromodulation

Conditions: Overactive Bladder

Summary: electrical stimulation of the sacral nerve can help with bladder problems and pelvic pain but researchers don't understand exactly how the stimulation helps. the goal of this study is to examine signals evoked during sacral neuromodulation (snm or electrical stimulation of the sacral nerve) and their relationship to the selection of stimulation parameters that improve pelvic function symptoms. this study uses snm parameters based on visual-motor responses (vmr) or sacral evoked responses (ser). it is investigating how the parameter selection impacts change in bladder function.

some surgical procedures will be conducted at the chealsea hospital (75 s main st, chelsea, mi 48118) and all others will be done at michigan medicine facilities.

Eligibility criteria:
inclusion criteria: * determined by the research team to be fully eligible to receive a sacral neuromodulation implant at a sacral nerve as part of their normal clinical care for overactive bladder (oab). * adult (18 or older), capable of providing own informed consent and communicating clearly with research team. * capable of speaking, reading, and understanding english, as all study questionnaires are standardized assessments only available in english. exclusion criteria: * areflexive or atonic bladder. * pregnant or planning to become pregnant. if a woman of child-bearing potential wishes to participate in this study, they will be pre-screened with a test to detect pregnancy. * diagnosed neurogenic bladder, sacral nerve damage, lower motor dysfunction, or other conditions that would affect the neural circuits involved in micturition.
study to evaluate psoriasis severity and its psychosocial impact using the simplified psoriasis index (spi), as well as long-term safety, tolerability and efficacy of secukinumab administered subcutaneously in patients with moderate to severe psoriasis

Conditions: Psoriasis

Summary: evaluate psoriasis severity and its psychosocial impact using a novel patient reported outcome (the simplified psoriasis index spi) at 16 weeks, as well as long-term safety, tolerability and efficacy of secukinumab administered subcutaneously during 52 weeks (plus extension) in patients with moderate to severe psoriasis.

study to evaluate psoriasis severity and its psychosocial impact using the simplified psoriasis index (spi), as well as long-term safety, tolerability and efficacy of secukinumab administered subcutaneously in patients with moderate to severe psoriasis

Eligibility criteria:
inclusion criteria: * patients with a history of chronic, moderate to severe plaque psoriasis (pasi ≥12; bsa (body surface area) ≥10 and iga mod 2011 (investigator's global assessment) ≥3) for at least 6 months * patient candidates for systemic therapy. * informed consent. exclusion criteria: * previous treatment with agent targeting il-17 (interleukine-17) or il-17 receptor. * recent treatment with topical treatment (2 weeks), systemic agents (4 weeks for methotrexate, ciclosporine a; systemic retinoids and other systemic treatment), tnf (tumor necrosis factor) inhibitors (3 months) or il-12/23 inhibitors (6 months).

Keywords: psoriasis secukinumab simplified psoriasis index cain457a ain457afr01 ain457a skin condition skin disease itching condition psoriasis vulgaris relapsing/remitting psoriasis immune-mediated systemic disease skin lesions red skin lesions scaly patches papules plaques itching