Kornimate/medical-research-clean huggingface dataset:
effects of an interactive ict-platform for assessment and management of symptoms in patients treated for prostate cancer

Conditions: Prostate Cancer

Summary: the purpose of this study is to evaluate the effects of an interactive ict-platform for use in a smartphone or tablet in patients treated with radiotherapy for prostate cancer. the hypothesis is that clinical management will be improved and costs reduced and safe and participatory care promoted, when patients report symptoms in an application which provides self-care advice and instant access to professionals.


Eligibility criteria:
inclusion criteria: * diagnosis of prostate cancer without metastases or spread to the lymph nodes, * will receive radiation therapy for at least five (5) weeks, * literacy in the swedish language exclusion criteria: * patients who need an interpreter at the doctor's visit * patients who have a known severe cognitive impairment

Keywords: prostate cancer nursing health literacy quality of life radiotherapy oncology nursing self care symptom management participatory care person-centered care information and communication technology patient-reported symptoms mobile device
early urinary continence after radical prostatectomy: surgical procedure and anatomic landmarks

Conditions: Prostatic Cancer; Surgical Procedure, Unspecified; Urinary Incontinence

Summary: this study describes how to perform a correct prostatic apex and membranous urethra in order to preserve all anatomical elements that are necessary to achieve a very fast urinary continence after open/laparoscopic/robotic radical prostatectomy, avoiding positive surgical margins at this level.

this study describes a simple technical variation, aimed at the sparing of the muscle systems and neurovascular bundles in order to achieve high rates of urinary continence in the early postoperative period ( the first two months after surgery) in prostate cancer patients undergoing radical prostatectomy.

Eligibility criteria:
inclusion criteria: * age between 40 and 75 years * a body mass index lower than 35 hg/m2 * patients with organ-confined prostate cancer * signed informed consent exclusion criteria: * contraindications for laparoscopy
different effects of three recruitment maneuvers on the lung heterogeneity of acute respiratory distress syndrome

Conditions: Acute Respiratory Distress Syndrome

Summary: acute respiratory distress syndrome (ards) is the common disease in clinical, which pathophysiology is a lot of alveolar collapse and heterogeneity. recruitment maneuver is one of the important therapy for improvement of this phenomenon. the previous research focuses on the hemodynamic and oxygenation effect of recruitment maneuver on the lung of ards. seldom investigators try to find the intuitive change of heterogeneity when recruitment maneuver is implemented. in this study, the investigators compare three recruitment maneuvers on the lung heterogeneity of ards.

acute respiratory distress syndrome (ards) is the common disease in clinical,which pathophysiology is a lot of alveolar collapse and heterogeneity. recruitment maneuver is one of the important therapy for improvement of this phenomenon. the previous research focuses on the hemodynamic and oxygenation effect of recruitment maneuver on the lung of ards. seldom investigators try to find the intuitive change of heterogeneity when recruitment maneuver is implemented. in this study, the investigators compare three recruitment maneuvers on the lung heterogeneity of ards. electrical impedance tomography (eit) has been introduced as a true bedside and radiation-free technique which provides information on heterogeneity. the investigators compare effects of three recruitment maneuvers on lung heterogeneity before recruitment maneuver and do the same thing after three recruitment maneuvers. ninety-three patients with ards will be enrolled . these patients are treated routinly.they need to recept a time of zeep (peep is zero cmh2o)for ten respiratory cycles before rm(recruitment maneuvers).implemente a kind of rm at random immediately after zeep,then make the ventilator same as before zeep.the eit images ,blood gases and hemodynamic variables will be examined as beseline between zeep and rm.completion of this kind of rm lies that the p/f of blood gases 3 minutes after rm achieves (1) po2/fio2\>400mmhg or (2)po2/fio2+pco2 ≥ 400mmhg(fio2=1)，(3)the difference between this index before lung recriument and after lung recriument po2/fio2\<5%.in addition,3 minutes after rm,compare the indexs above between three methods.

Eligibility criteria:
inclusion criteria: * patients who are severe or moderate ards * patients who have signed icf exclusion criteria: * patients who are younger than 18 years old or older than 75 years old * patients whose vital signs are unstable * patients who are in other clinical trails * patients who are pregnant

Keywords: ards eit recruitment maneuvers
pilot randomized controlled trial of a collaborative agenda-setting intervention (casi) for patients with ovarian cancer

Conditions: Ovarian Cancer; Ovarian Neoplasms; Ovarian Carcinoma

Summary: this research is being done to test a new communication tool for people with ovarian cancer, caregivers, and clinicians. the name of the intervention in this research study is: -collaborative agenda-setting intervention (casi)

this two-arm, parallel group-randomized research study is to test a new communication tool (casi) for people with ovarian cancer, caregivers, and clinicians. this is a pilot feasibility study, which means this is the first time researchers are studying casi. clinicians will be randomized into one of the two study groups, arm 1 or arm 2, and patients and caregivers will be enrolled in the study arm to which their clinician has been randomized. the research study procedures include screening for eligibility, audio recorded clinic visits, and questionnaires. participation in this research study is expected to last for up to 12 weeks for patients and caregivers, and for up to 52 weeks for clinicians. it is expected that up to 112 people will take part in this research study, including up to 50 patients, 50 caregivers, and 12 clinicians (six dyads). the national institute for nursing research is supporting this research by providing funding.

Eligibility criteria:
participant inclusion criteria: * at least 18 years old * able to speak, understand, and respond to questions written in english * willing to be audio recorded * have a diagnosis of advanced ovarian cancer (defined as stage iii, stage iv, or recurrent disease) * be under the care of a participating clinician dyad * be scheduled for chemotherapy during the recruitment period * be signed up or willing to sign up for patient gateway caregiver inclusion criteria: * at least 18 years old * able to speak, understand, and respond to questions written in english * willing to be audio recorded * be a family member, partner, or friend of a patient participant with whom the patient participant discusses their cancer care clinician inclusion criteria: * be employed at dfci as an oncologist, nurse practitioner, or physician assistant * take care of at least 4 patients per month with advanced ovarian cancer (defined as stage iii, stage iv, or recurrent disease) in the outpatient setting participant exclusion criteria: * age of \<18 years * unable to consent

Keywords: ovarian cancer ovarian neoplasms ovarian carcinoma
home-based self-management and cognitive training changes lives (hobscotch) - multiple sclerosis (ms)

Conditions: Multiple Sclerosis; Cognitive Dysfunction; Memory Disorders

Summary: the goal of this pilot study is to assess the feasibility of adapting and delivering the existing home-based epilepsy self-management intervention, hobscotch, for people with multiple sclerosis (ms). the main questions it aims to answer are: 1. can the current hobscotch program be adapted for people with ms? 2. will people with ms experience improved quality of life similar to that found in people with epilepsy after participating in the hobscotch program? participants will be asked to: * attend nine, one-hour virtual (online and/or by telephone) hobscotch-ms sessions with a one-on-one certified hobscotch-ms coach * complete a brief clinical questionnaire about their diagnosis of ms * complete four questionnaires before and after the hobscotch-ms sessions about their quality of life and about memory and thinking processes * keep a short daily diary about their ms symptoms and use of the self-management strategies taught in the hobscotch-ms program * complete a brief satisfaction survey after the entire hobscotch-ms program


Eligibility criteria:
inclusion criteria: * age 20 - 65 years * literate, english-speaking with grade 12 or equivalent in education * self-reported diagnosis of ms * self-reported cognitive/memory difficulties * telephone and internet access exclusion criteria: * cognitive dysfunction that precludes participation in giving informed consent * significant visual impairment precluding reading or writing * no reliable telephone or internet access * acute psychiatric illness * history of progressive neurodegenerative disease (dementia)

Keywords: multiple sclerosis memory disorders cognition self-management
effect of increasing motor cortex inhibition on task specific dystonia

Conditions: Dystonia

Summary: dystonia is a disease where muscles in the affected body part are abnormally active. this may result in abnormal postures. the underlying mechanisms are not known. one proposed mechanism is located in the motor area of the brain that controls the coordination of muscles, called the motor cortex. it is well known that the motor area of one hemisphere of the brain (motor cortex) controls the movement of the opposite side of the body. when people perform tasks such as picking up an object or writing there are mechanisms in motor cortex that focus the level of activity so that they can do these tasks with a high level of precision. focusing activity in motor cortex seems to be disturbed in people with dystonia. transcranial magnetic stimulation (tms) is a device that allows the non-invasive stimulation of the brain. when applied to the motor cortex it can upregulate or down regulate its activity. in the present study the investigators will conduct experiments on subjects with task specific focal hand dystonia (such as writers cramp) using tms to decrease unwanted motor activity. the investigators will assess the effects of this intervention using objective, subjective and kinematic measures. this is a pilot study and will require further research to assess the long-term effects of repetitive tms on task-specific focal hand dystonia.


Eligibility criteria:
inclusion criteria: * if you are treated with botulinum toxin, the testing should be done at least 3 months after your last botulinum toxin injections. * adult patients with task-specific dystonia strictly confined to one hand since the onset of symptoms * no dystonic movements at rest * normal mri scan of the brain as per clinical record * no intake of cns active drugs that may interfere with the study * no contraindication for tms * ability to perform the selective task * no other neurological disease that may interfere with the study * ability to give informed consent exclusion criteria: * you have a history of migraines * you have a diagnosed seizure disorder * you take any central nervous system cns active drugs, such as benzodiazepines, lorazepam, baclofen, ssri's and other anti-depressants, etc. that may interfere with the response to tms. * you have any clips or implants in your head * you have a pacemaker

Keywords: dystonia transcranial magnetic stimulation rehabilitation plasticity
clinical trial of hr091506 tablets in treatment of gout with hyperuricemia in adults

Conditions: Gout With Hyperuricemia in Adults

Summary: the study is being conducted to evaluate the efficacy, and safety of hr091506 tablets for treatment of gout with hyperuricemia in adults, and to compare the results with febuxostat tablets in the same doses.


Eligibility criteria:
inclusion criteria: 1. 18-75 years old, male or female; 2. meet the 2015 acr/eular gout classification criteria; 3. fast serum uric acid ≥ 480 μmol/l on 2 different days during the screening perid; 4. patients with tophi, chronic arthropathy, frequent attacks; 5. willing to ues contraceptive measures during the study; 6. able and willing to provide a written informed consent. exclusion criteria: 1. history of acute gout attack within 4 weeks before randomization. 2. subjects who have undergone major surgery or organ transplantation within 3 months before randomization. 3. subjects with major cardiovascular disease within 6 months before randomization. 4. history of chronic infection or recurrent infection within 1year before randomization. 5. history of malignant tumor or current history of combined malignant tumor within 5 years before screening. 6. history of secondary hyperuricemia, refractory gout, or xanthine metabolism disorder. 7. subjects with poorly controlled blood pressure or diabetes mellitus. 8. history of chronic diffuse connective tissue disease and/or massively elevated urate diseases and/or untreated clinically significant thyroid disease. 9. history of diseases that may affect the in vivo process, safety evaluation, or subjects' participation in the research. 10. abnormal laboratory tests that may affect subjects participating in the research. 11. combined use of prohibited drugs. 12. allergic to ingredient or component of the experimental drug. 13. participated in other clinical trials within 1 month before randomization. 14. pregnant or nursing women. 15. history of drug abuse, drug use and/or excessive drinking within 1 year before screening. 16. the inestigators determined that other conditions were inappropriate for participation in this clinical trial.
interactive mobile health intervention to improve early postpartum modern contraceptive method uptake

Conditions: Other Cardiovascular Diseases of Mother, Postpartum

Summary: the main aim of this study is to determine effectiveness of mobile health intervention to improve early postpartum modern contraceptive service uptake among postpartum women in dessie and kombolcha town zones, north east ethiopia. this study will be conducted in dessie and kombolcha zones in amhara region, north east ethiopia. the largest sample size will be taken and total sample size will be 784.

the main aim of this study is to determine effectiveness of mobile health intervention to improve early postpartum modern contraceptive service uptake among postpartum women in dessie and kombolcha town zones, north east ethiopia. this study will be conducted in dessie and kombolcha zones in amhara region, north east ethiopia. the largest sample size will be taken and total sample size will be 784. cluster randomized control trial behavioral intervention sampling technique will be deployed. first participants will be grouped in to two arms based on randomization of clusters. the intervention arm will take the new mobile health intervention with existed health care practice and the control arm will take the existed current health care practice. intervention mobile health messages will be developed from family planning behavior change framework and national guidelines. data will be collected by using pre-tested interviewer administered structured questionnaires. data will be collected in four different phases. open data kit (odk) will be used for data collection. duration of intervention will be 4 months. descriptive analyses will be made by computing proportions and summary statistics. statistical package to social science (spss.26) and stata.15 soft wares will be used to do analysis. structural equation modeling (sem) or path analysis will be done to identify the fitted components to determine latent variables.

Eligibility criteria:
inclusion criteria: all mothers who will be 24-28 week of gestation and have access to mobile phone in the study area will be recruited to this study. exclusion criteria: * pregnant women, who will be assumed to have serious medical problems, will be excluded.

Keywords: early post partum, contraceptive method, ethiopia
optimal site for rapid urease test in the stomach

Conditions: Helicobacter Pylori Infection

Summary: the accurate diagnosis of h. pylori infection is an important step for establishing the strategy for gastric cancer prevention. during endoscopy, rapid urease test (rut) is the first of biopsy-based h. pylori tests. despite indirect test for h. pylori detection, rut shows rapid result with good sensitivity and specificity. several study reported that h. pylori density was related to positive reaction time of rut. however, there was no study comparing the positive reaction times of rut according to biopsy site, degree of gastric atrophy, and intestinal metaplasia.

the aims of this study were to: (1) assess the positive reaction times of rut in the body and antrum, (2) investigate the association between the difference of rut results (body and antrum) and gastric atrophy, and intestinal metaplasia, and (3) evaluate the optimal biopsy site for rut according to degree of gastric atrophy in korean population.

Eligibility criteria:
inclusion criteria: * subjects who underwent upper endoscopy and rapid urease test exclusion criteria: * : age \ 70 years; anemia (serum hemoglobin level \< 10 g/dl); severe systemic disease or advanced chronic liver disease; use of certain medications, including proton pump inhibitors, h2-receptor antagonists, or antibiotics; a history of h. pylori eradication; a history of gastric surgery; a recent history of upper gastrointestinal bleeding.
a study of capecitabine [xeloda] in combination with trastuzumab [herceptin] and oxaliplatine in patients with resectable gastric cancer

Conditions: Gastric Cancer

Summary: this study will evaluate the disease free survival rate of a combination of capecitabine \[xeloda\] and oxaliplatin (xelox) with trastuzumab \[herceptin\] in patients with resectable gastric cancer. the combination of xeloda (orally, 1000 mg/m2 on day 1-14 of every cycle) and herceptin (intravenously, 8 mg/kg loading dose, then 6 mg/kg on days 1-14 of every cycle) will be administered for three cycles prior to surgery to resect the tumor. if complete resection, r0 or microscopic residual tumor r1 is achieved, patients will continue with three cycles of xelox and herceptin and then for completion of 12 months treatment with herceptin alone. oxaliplatin will be administered intravenously at a dose of 130 mg/m2 on day 1 in every cycle. the anticipated time on study drug will be 12 months.


Eligibility criteria:
inclusion criteria: * adult patients over 18 years of age * locally advanced resectable her2-positive gastric or esophagogastric junction adenocarcinoma (sievert types i, ii, iii) * measurable (recist criteria) or assessable disease * ecog performance 0-2 * life expectancy of 12 weeks or more exclusion criteria: * immeasurable lesion as the only evidence of disease * previous chemotherapy or radiotherapy for gastric neoplasm or some kind of previous surgical resection of the tumor (except diagnostic laparoscopy) * concomitant heart disease
responsible side effects management in oncology

Conditions: Pharmacovigilance; Oncology; Antineoplastic Treatment

Summary: study of pharmacovigilance in oncology. monitoring and management of aes during antineoplastic treatment.

monitoring and management of ae's during antineoplastic treatment. comparison of ae's reported by patient with the ones recognised by the oncologist, and vice versa, during antineoplastic treatment.

Eligibility criteria:
inclusion criteria: all cancer patients receiving systemic antineoplastic treatment, ecog 0-2 exclusion criteria: age \ 75; other active and severe comorbidities; no solid cancer; iuc patients

Keywords: pharmacovigilance in oncology antineoplastic treatment adverse events
flt-pet imaging of brain tumors in children

Conditions: Brain Neoplasms

Summary: brain tumors are the leading cause of death from solid tumors in children. tumor imaging is important in the management of these tumors, but current imaging methods have limitations in providing the necessary information for optimal treatment of these patients. the goal of this study is to evaluate the potential utility of positron emission tomography (pet) with 3'-deoxy-3'-\[f-18\] fluorothymidine (18f-flt) in the medical management of brain tumors in children. funding source - fda office of orphan product development (oopd)

although pediatric central nervous system tumors are rare, they are a significant contributor to morbidity and mortality in children. tumor staging, detecting recurrent tumor, and assessing the response to therapy are critical in the treatment of brain tumors, but current imaging methods have major limitations in providing such information. the objective of this study is to validate 3'-deoxy-3'-\[f-18\] fluorothymidine (18f-flt) as a measure of tumor proliferation and to demonstrate the utility of 18f-flt as a pet imaging agent in children with central nervous system tumors. the proposed studies will evaluate 18f-flt pet in three groups: 1. children with a new diagnosis of central nervous system tumor. 2. children in whom conventional imaging has raised concern for possible recurrence of a central nervous system tumor. 3. children receiving post-operative chemotherapy for a central nervous system tumor. in these three groups, correlation of 18f-flt uptake with tumor histopathology and patient outcome will be used to assess the utility of 18f-flt for grading tumors at diagnosis, for accurate identification of tumor recurrence, and for early assessment of the response to chemotherapy.

Eligibility criteria:
inclusion criteria: * age 21 years or less * capable of achieving imaging without need for sedation or anesthesia (typically age 8 years or greater, but there is no lower limit for age for eligibility) * karnofsky performance status of 50 or greater in subjects age 12 years or greater, for age less than 12 years a lansky play scale of 50% or greater * patients receiving steroids and/or anti-seizure medications are eligible exclusion criteria: * clinically active infection * pregnancy or breast-feeding * serious intercurrent medical illness * require emergency surgical intervention that would be inappropriately delayed by flt-pet imaging

Keywords: brain neoplasms children positron-emission tomography 18f-flt