Kornimate/medical-research-clean huggingface dataset:
the diagnostic value of rigiscan test (nocturnal penile tumescence and rigidity, nptr) in chinese males

Conditions: Erectile Dysfunction

Summary: the purpose of this study is to evaluate the diagnostic value of rigiscan (nocturnal penile tumescence and rigidity, nptr ) test in erectile dysfunction of chinese males.

the rigiscan test is used to evaluate the nptr parameters. the "normal" nptr parameter is provided by the rigiscan manufacturer based on a clinical study on 500 american males. original studies of nptr parameters on chinese males are warranted. on the other hand, during the past decades, several new nptr parameters have been developed, like tip tau (tip tumescence activity units), tip rau (tip rigidity activity units), base tau (base tumescence activity units), base rau (base rigidity activity units), but their diagnostic values have been less evaluated. basd on the these background, we determined to observe the clinical manifestation of these new parameters and to establish the "normal criteria" of nptr parameters in chinese males. this could be clinically beneficial in the differential diagnosis of organic and psychological erectile dysfunction.

Eligibility criteria:
inclusion criteria: 1. patients in a stable and heterosexual partnership with a fixed sexual partner for more than 6 months; 2. age≥20 year; 3. complete the validated international index of erectile function (iief-5) questionnaire. exclusion criteria: 1. advanced age (≥65); 2. pelvic trauma 3. thyroid diseases 4. metabolic diseases 5. hypogonadism and other hormonal disorders 6. sleep disorders 7. penile deformities 8. taking drugs that may interfere with erectile function.

Keywords: nocturnal penile tumescence and rigidity erectile dysfunction chinese males
peer mentoring for persons with spinal cord injury (sci)

Conditions: Spinal Cord Injury

Summary: a peer mentoring program for persons with sci was developed. individuals who experienced sci in the past and have adapted well functionally were asked to serve as mentors for individuals with newly-acquired sci. these individuals undergo volunteer and peer mentoring training prior to mentoring activities. they are a subset of the study participants. we are tracking their satisfaction with life, positive and negative affect, life adjustment, depression, and social support over time. we hypothesize that measures of adjustment will become more positive as involvement as a mentor increases. the second subset of study participants are the individuals with newly-acquired sci. they complete a baseline assessment of the measures listed above and then at 6 months, one year, and two years after match with a mentor. we also collect information about the quantity and quality of the mentoring sessions from both the mentor and mentee. we hypothesize that the mentee's adjustment will be positively influenced by the number and quality of the mentoring sessions. due to the relatively small number of sci per year in our program, we opted to offer the mentoring program to all individuals with newly acquired sci, thus there is no control group.


Eligibility criteria:
inclusion criteria: * experienced a sci exclusion criteria: * no severe traumatic brain injury * no severe psychiatric disturbance
effect of physical therapy and/or platelet rich plasma injection in people with knee cruciate ligament injuries

Conditions: Anterior Cruciate Ligament Tear; Posterior Cruciate Ligament Tear

Summary: background: the anterior cruciate ligament(acl) , one of the major ligaments in the knee joint which connects the posterior aspect of the lateral femoral condyle to the anterior intercondylar area of the tibia. it plays a crucial role in maintaining knee joint stability, preventing excessive rotation of the tibia, and controlling the angles of knee valgus and varus. additionally, the acl contains mechanoreceptors that contribute to proprioception input. acute acl injuries are characterized by joint effusion, instability, and reduced range of motion. in the chronic phase, instability and pain may occur during rotational and cutting movements. currently, regenerative injection therapies such as high-concentration platelet-rich plasma (prp)and bone marrow concentrate (bmc) are being explored for acl repair. studies have found that postoperative administration of high-concentration prp significantly reduces pain and improves knee joint function for a duration of 3 to 6 months, but these effects are not sustained beyond 12 months. in addition, some research indicates that high-concentration prp does not enhance graft healing or improve knee joint stability. method: this is a single-institution, single-blind, observational study conducted by the rehabilitation department of a public hospital. the study aims to recruit 40 participants with anterior cruciate ligament (acl) or posterior cruciate ligament (pcl) injuries. the treatment intervention is collaboratively determined by the physician and the participant during the clinic visit. subsequently, a therapist, unaware of the treatment details, conducts baseline assessments, including basic information collection, balance testing, gait analysis, timed up and go test, muscle strength evaluation, and subjective knee assessment questionnaire. additionally, a physician, blinded to the treatment content, employs ultrasound to assess ligament elasticity. follow-up assessments are conducted for the same parameters two months later.


Eligibility criteria:
inclusion criteria: 1. age between 18 to 80 years old. 2. magnetic resonance imaging (mri) shows partial tearing of the anterior cruciate ligament (acl) or posterior cruciate ligament (pcl), possibly combined with injuries to the medial collateral ligament (mcl) or meniscus. 3. no surgical treatment has been undergone. exclusion criteria: 1. had knee joint diseases or undergone knee joint surgery before the injury. 2. surgical intervention is required for severe damage to knee joint ligaments, meniscus, or articular tissues, such as complete rupture of lateral ligaments or full-thickness cartilage injuries. 3. suffers from diseases affecting physical activity function, such as stroke or nerve damage.

Keywords: prp therapeutic exercise modality physical therapy
effect of tele-yoga therapy on patients with chronic musculoskeletal pain during covid-19 lockdown

Conditions: Chronic Musculoskeletal Pain

Summary: covid-19 outbreak and lockdown measures raised significant concerns over clinical management of chronic pain patients around the world. patients with chronic musculoskeletal pain (cmsp) are at high risk of physical disability, psychological distress, and poor quality of life. analgesic medications were main management during lockdown, but opioid-related concerns have prompted to find immediate alternatives. present study was undertaken to determine whether patients randomized to tele-yoga therapy would experience less pain, disability and improved global health, adherence and satisfaction, compared with patients assigned to usual care.


Eligibility criteria:
inclusion criteria: * patients having pain that was musculoskeletal, defined as regional (joints, limbs, back, neck) or more generalized (fibromyalgia or chronic widespread pain); * persistent pain ( ≥3 months) despite trying conventional treatment. * access to virtual platform with internet. * ready to give informed consent exclusion criteria: * schizophrenia, * psychiatric disorder * cognitive impairment * suicidal ideation * current illicit drug use * terminal illness

Keywords: tele-yoga therapy chronic musculoskeletal pain randomized controlled trial
study with rituximab-gemcitabine/oxaliplatin in relapsed indolent lymphoma

Conditions: Indolent Lymphoma

Summary: the purpose of the phase i part is to determine the tolerability, the initial safety profile and maximum tolerated dose of oxaliplatin in combination with gemcitabine for indolent lymphoma. in the phase ii part the investigators want to estimate the activity of gemcitabine and oxaliplatin in combination with rituximab for patients with relapsed/refractory indolent lymphoma.


Eligibility criteria:
inclusion criteria: * need for therapy in patients with relapsed/refractory patients * histological proven diagnosis of an indolent b-cell lymphoma according to the world health organization (who) classification belonging to one of the following entities: * follicular lymphoma * mantle cell lymphoma * lymphoplasmacytic lymphoma * nodal or splenic marginal zone lymphoma * measurable disease * lymphoma specific therapy in the last four weeks * who performance grade 0, 1 or 2 exclusion criteria * patients suitable for high dose therapy * transformation in high grade lymphoma * leukocytes \< 1,5/nl or platelets \< 100/nl (except due to lymphoma)

Keywords: relapsed indolent lymphoma gemcitabine oxaliplatin rituximab
surface mechanomyography using a parasternal patch to measure and detect respiratory drive and effort

Conditions: Acute Respiratory Failure

Summary: surface mechanomyography (smmg) has been proposed as a tool to study muscle mechanical activity. smmg is a noninvasive technique using specific transducers to record muscle surface oscillations due to mechanical activity of the motor units . it could be of major interest for the detection of respiratory efforts in patients with respiratory failure. this study aims at assessing the performances of smmg to measure and detect respiratory drive and effort in healthy volunteers.


Eligibility criteria:
inclusion criteria: * healthy volunteer * age \> 18 and \< 60 * informed consent * fasting * subjects covered by or having the rights to medical care assurance exclusion criteria: * obesity (bmi \> 30 kg.m-2) * respiratory disease * cardiovascular disease * contraindication to the insertion of a nasogastric tube * incapacity to consent * pregnancy, breastfeeding * bad understanding of the french language, * other protected person according to articles l1121.7 and l1121.8 of the french public health act.

Keywords: acute respiratory failure surface mechanomyography respiratory effort
effects of taking prenatal vitamin-mineral supplements during lactation on iron status and markers of oxidation

Conditions: Iron Overload; Oxidative Stress; Iron-deficiency Anemia

Summary: most breastfeeding women are told by their health care provider to continue taking prenatal vitamins after they give birth. a woman's requirement for iron while breastfeeding is low, yet prenatal vitamins contain a large amount of iron. the purpose of this study is to see if breastfeeding women are getting too much iron when taking prenatal vitamins.

even though iron requirements are much lower for lactating women than for pregnant or non-pregnant, non-lactating women, and iron stores during lactation are often high due to release of iron from the additional maternal erythrocytes produced during pregnancy, iron supplements are often taken by lactating women in the u.s. many studies have shown that higher iron status is associated with higher risk of certain chronic diseases (e.g. cancer and cardiovascular diseases). the overall goal of this proposed study is to understand the potential for oxidative stress due to iron supplementation, and possible mechanisms for these effects, and to identify safe and efficacious ways to ensure adequate iron status during lactation. the specific aims are: 1. to compare markers of lipid oxidation (urinary isoprostane) and dna damage (urinary 8-ohdg (urinary 8-hydroxy-2'-deoxyguanosine)) among 3 treatment groups: (iron given between meals (27 mg daily, in a multivitamin-mineral supplement), iron given with meals (27 mg daily, in a multivitamin-mineral supplement) and multivitamin-mineral supplement with no iron, given between meals) at the beginning and end of 3 months of treatment in 114 lactating women. 2. to compare hemoglobin and iron status (ferritin, transferrin saturation, and hepcidin) before and after treatment among the three treatment groups described above.

Eligibility criteria:
inclusion criteria: * women less than 4 weeks postpartum * 18 years of age or older * took prenatal vitamins for at least 3 months during pregnancy * successfully initiated breastfeeding exclusion criteria: * anemic (hgb \< 110 g/l)

Keywords: lactation breastfeeding iron oxidative stress iron status and oxidative stress during lactation
sequential application of yisaipu® and dmards in treating mild-to-moderate as

Conditions: Ankylosing Spondylitis

Summary: the drug regimes in treating ankylosing spondylitis(as) have limitations. the tumor necrosis factor inhibitors(tnfi) was effective but expensive. disease modifying anti-rheumatic drugs (dmards) were cheap but insufficient. this study proposed a sequential usage of tnfi, the yisaipu®, and dmards, and aims to evaluate the mid-term therapeutic effect of this new scheme in treating the mild-to-moderate as.


Eligibility criteria:
inclusion criteria: * 1.clinical diagnosis of ankylosing spondylitis(as) based on modified new york diagnostic criteria for as (1984) 2.at the mild-to-moderate stage of as disease 3.at the active phase of as disease exclusion criteria: * 1.active tuberculosis, hepatitis, tumors, infection diseases or combine with other rheumaimmune systemic diseases or osteoarthritis diseases 2.pregnant or breastfeeding women

Keywords: ankylosing spondylitis(as) tnfi yisaipu® disease modifying anti-rheumatic drugs (dmards)
leveraging technology to achieve equity for men with prostate cancer on androgen deprivation therapy

Conditions: Prostate Cancer

Summary: this clinical trial studies a digital platform, the supportive therapy in androgen deprivation (stand-t), in achieving equity for men undergoing treatment with androgen deprivation therapy for prostate cancer. stand-t is a digital platform that provides prostate health information, evidence-based materials and resources. stand-t may help improve health, address symptoms, and promote equity in men with prostate cancer.

primary objective: i. to assess study feasibility of the stand-t program at the helen diller family comprehensive cancer center (hdfccc) and zuckerberg san francisco general hospital and trauma center (zsfg) genitourinary (gu) medical, surgical, and radiation oncology practices. secondary objective: i. to measure preliminary estimates of acceptability and usage of a digital platform, stand-t. exploratory objective: i. to describe diet (e.g., fruit and vegetable intake), lifestyle (e.g., moderate to vigorous exercise, smoking status), clinical (symptoms e.g., fatigue), and health related quality of life (qol) outcomes (e.g., sleep disturbance), physiologic measures (body mass index, bmi) at baseline and change in these metrics from baseline to 3 months post-intervention. outline: patients review educational material and resources via online stand-t platform. patients also receive interactive text messages for 3 months. after completion of study, patients are followed up at 3 months.

Eligibility criteria:
inclusion criteria: * age \>18 years * ability to understand study procedures and to comply with them for the entire length of the study * ability of individual or legal guardian/representative to understand an informed consent document and the willingness to sign it * adenocarcinoma of the prostate * current or planned anti-androgen therapy (adt) (oral or injection) with gonadotropin-releasing hormone (gnrh) antagonist or luteinizing hormone releasing hormone (lhrh) agonist * life expectancy duration of 6 months or longer from date of study consent * prior and concurrent radiation is allowed * treatment with concurrent androgen signaling inhibitors is allowed * \< 75 minutes/week of vigorous aerobic exercise based on godin survey or \< 2 days per week of vigorous activity exclusion criteria: * contraindication to any study-related procedure or assessment * planned surgery/chemotherapy/immunotherapy/parp inhibitor treatment during the study period * prior and concurrent investigational therapies * unable to read/speak english * unable to access the internet * has seen an exercise counselor in the past 6 months for prostate or cardiovascular health * has seen a dietary counselor in the past 6 months for prostate or cardiovascular health

Keywords: health technologies
pediatric exercise with congenital heart defects (kinderturnen mit angeborenem herzfehler)

Conditions: Heart Defects, Congenital

Summary: children with congenital heart defects have shown to develop motor coordinative deficiencies. in this study we want to show that a motor pedagogic physical training can improve the coordinative capabilities of children aged 4-6 years.

the study will be performed with a randomized crossover design. after the first assessment of coordinative capabilities children were randomized into two groups. one starts with exercised training for three months. after midterm assessment of the capabilities they will pause for another 3 months and reassessed. the second group will start without training for the first three months. after midterm assessment they will train for three months and have their final assessment.

Eligibility criteria:
inclusion criteria: * without significant residuals hemodynamically not significant * without significant residuals after repair * age 4-6 incl. exclusion criteria: * gradient at coarctation site \> 20 mmhg * gradient rvot, pv, lvot, or aov \> 30 mmhg * right-left shunt (rest or exercise) * left-right shunt with dilatation or failure of ana cardiac chamber * pulmonary hypertension * heart failure, necessitating therapy * (suspected) myocarditis or cardiomyopathy * significant arrhythmia * ion channel defects, other arrhythmic diseases * fontan-like circulation * repair by atrial switch * oral anticoagulation * other medical problems curtailing exercise capacity

Keywords: congenital heart disease exercise training motorpedagogical exercise children chd: hemodynamically not significant defects chd: acyanotic defects after repair chd: cyanotic defects after repair
pompe disease qmus and eim

Conditions: Pompe Disease

Summary: study objectives: 1. determine the correlation between quantitative muscle ultrasound (qmus), electrical impedance myography (eim) and currently accepted measures of physical function. 2. determine the reliability of eim measures performed in the home through use of a hand held device. 3. determine if qmus and eim can detect pre-clinical changes in pompe disease.


Eligibility criteria:
inclusion criteria: * genetically confirmed diagnosis of pompe disease. exclusion criteria: * age \<18 years * inability to provide informed consent.

Keywords: neuromuscular ultrasound electrical impedance myography
evaluation of the efficacy of intense pulse light combined with lipiflow in the treatment of meibomian gland dysfunction

Conditions: Meibomian Gland Dysfunction

Summary: to compare the effect of ipl combined with lipiflow and ipl combined with meibomian gland massage in treating meibomian gland dysfunction of different degrees ,focusing on effective rate, lasting time and changes of meibomian gland function and morphology.

to divide all participants into two groups, group one treated with ipl combined with lipiflow and group two treated with ipl combined with meibomian gland massage.the following parameters were recorded after treatment: the effective rate, lasting time and changes of meibomian gland function and morphology.all parameters were compared between the two groups.

Eligibility criteria:
inclusion criteria: * patients with meibomian gland dysfunction * patients with ocular discomfort * skin type:fitzpatricⅰ-ⅳ exclusion criteria: * patients with acute ocular inflammation * eye surgery history in the last 12 months * patients who have received ipl or lipiflow in the last 12 months * patients who wear contact lens in last one month
effects of locomotion training with assistance of a robot-driven gait orthosis in hemiparetic patients after subacute stroke

Conditions: Stroke; Hemiparetic Patients After Subacute Stroke

Summary: the investigators aimed in this study to investigate the effects of 4 weeks robot-assisted locomotor training on motor recovery of lower extremities and walking ability compared with the conventional gait training in subacute post-stroke non-ambulatory hemiplegic patients. 72 first-ever stroke patients who could not walk independently (fac \< 2), and suffered within 6 months were enrolled and randomly assigned into 2 groups. the subjects with congestive heart failure, malignancies, cardiopulmonary dysfunctions, and who could not walk independently before stroke attack were excluded. two groups received 30 minutes conventional gait training including neurodevelopmental treatment (ndt) basically. the robotic assisted locomotor training group received additional robotic-assisted gait therapy for 30minutes with lokomat® (hocoma, zurich, switzerland) daily for 4 weeks, and the conventional gait training group received additional daily conventional gait training with ndt for the same periods. the independent walking ability(fac ≥ 3), functional ambulation category (fac), motricity index (mi), fugl-meyer assessment (fma), modified barthel index (mbi), medical research council (mrc) for each lower extremity muscles were assessed before, during (2weeks) and after training. and the independent walking ability were followed until 3 months.


Eligibility criteria:
inclusion criteria: 1. hemiparesis as result of 1st stroke 2. no other neurologic or orthopedic disorder 3. independent ambulation before the stroke 4. no severe medical illnesses 5. hemiparesis: lower extremity strength graded ≤ 3 in more than 2 muscle groups 6. functional ambulation classification (fac) ≤ 1 : indicating a need for personal assistance in ambulation 7. the interval between stroke and start of the treatment 8. time since stroke onset \< 6 months 9. age: 20-80yrs old exclusion criteria: 1. unstable fractures 2. severe osteoporosis 3. severe skin problems 4. severe joint problems 5. major difference in leg length, 6. body weight over 130 kg, 7. orthostatic circulatory problem 8. severe cognitive impairment