Kornimate/medical-research-clean huggingface dataset:
lifestyle intervention in obese children attending special primary education.

Conditions: Overweight; Obesity

Summary: the purpose of this study is to assess the prevalence of overweight and obesity in children attending special primary education and to evaluate the effects of a multidisciplinary school-based lifestyle intervention.

lifestyle changes related to high-fat diets and low levels of physical activity have resulted in a rising prevalence of overweight and obesity in children and adolescents. ten per cent of the world's school-aged children are estimated to have excess body fat. overweight and obesity during childhood and adolescence tend to continue into adulthood, increasing the likelihood of a range of impaired health conditions including cardiovascular diseases, diabetes and some cancers. school-based interventions have been proposed to prevent or treat obesity and have been described as a promising approach to reducing obesity among youth. first the extent and the characteristics of the problem have to be assessed for different types of education. comparison(s): the prevalence of overweight and obesity in special primary education will be compared to the prevalence in regular primary education. in special primary education, obese and overweight children will be randomised into a experimentel group (6 months of lifestyle intervention including diet and physical activity) and a control group (6 months normal treatment, if any, e.g. exercises for motor skills).

Eligibility criteria:
inclusion criteria: * children attending special and regular primary education exclusion criteria: * endocrine conditions affecting bodyweight (e.g. thyroid disease, diabetes) * mental or physical disabilities that make it impossible to participate in sports activities

Keywords: childhood obesity lifestyle intervention school health program special primary education
chronic knee pain study

Conditions: Knee Osteoarthritis

Summary: specific aims: 1) to examine differences between aa and white patients with knee oa in willingness to consider knee joint replacement. 2) to examine the relationship between socio-cultural factors and patient willingness to consider joint replacement. 3) to examine how demographic, socio-cultural, and clinical factors mediate the relationship between race and patient willingness. 4) to examine the relationship between patient willingness and referral to orthopedic care for knee oa (secondary aim). experimental design/methodology: a cross-sectional survey study design will be used to examine socio-cultural and clinical factors that may vary by race/ethnicity and may be determinants of willingness to consider joint replacement as a treatment option. patients with symptomatic and radiographic knee oa from the primary care clinics will be surveyed. only individuals with knee oa of sufficient severity that would be considered candidates for joint replacement will be included. analytic strategies include ordinal logistic regression, path analysis, and regression trees. subject population: the study sample will consist of approximately 133 african american and 419 white patients with oa of the knee in a primary care setting.


Eligibility criteria:
inclusion criteria: * over age 50 * chronic knee pain * radiographic evidence of knee oa exclusion criteria: * previous joint replacement * inflammatory arthritis
renal sympathetic denervation and insulin sensitivity (rensympis study)

Conditions: Resistant Hypertension

Summary: hypertension is a major risk factor for stroke and cardiovascular mortality. catheter- based renal denervation causes substantial and sustained blood- pressure reduction in patients with resistant hypertension. the purpose of rensympis is to study the effects of renal denervation on: 1. cardiovascular function 2. metabolic factors 3. inflammatory and endocrine factors 4. coagulation 5. sleep


Eligibility criteria:
inclusion criteria: * resistant hypertension (systolic blood pressure \>160mmhg and 3 or more antihypertensive agents in use) * age 30- 69 years * written informed consent exclusion criteria: * secondary hypertension * pseudohypertension * pregnancy * renal insufficiency (gfr \<45ml/min) * clinically significant stenotic valvular disease * oral anticoagulation * ccs iii-iv symptoms or cabg/pci in previous 6 months * prior stroke * contrast agent allergy * inappropriate renal artery anatomy (\< 4mm diameter, \< 20mm length)
study of gastric motility in eosinophilic gastritis

Conditions: Eosinophilic Gastritis; Gastroparesis; Gastric Motility Disorder

Summary: purpose: the study is a cross-sectional observational study designed to determine if eosinophilic gastritis (eg) results in gastric motility impairment. hypothesis: gastric dysfunction occurs in the natural history of eg but is underdiagnosed due, in part, to contraindications to the use of the standard meals used in gastric emptying studies.


Eligibility criteria:
inclusion criteria: * eosinophilic gastritis (eg) defined as at least one endoscopy with histopathologic evidence of ≥ 30 eosinophils in 5 or more high powered fields (hpf's) with associated symptoms of eg. * patient reported symptoms starting at least one year or more prior to screening consistent with a diagnosis of eg: nausea, vomiting, early satiety, abdominal pain/bloating, regurgitation, diarrhea. * symptoms suggestive of a possible gastric motility disorder during the 60 days prior to screening including: nausea, vomiting, early satiety, post-prandial feeling of fullness or bloating. * tolerance and willingness to consume the oatmeal meal in this study. exclusion criteria: * diagnosis of eosinophilic enteritis. * inflammatory bowel disease (e.g., crohn's disease or ulcerative colitis). * known disorders associated with eosinophilic gastrointestinal (gi) diseases (e.g., d 816 v kit+ systemic mastocytosis, marfan syndrome or loey's dietz syndrome). * known inflammatory or autoimmune disorders associated with gastric dysmotility such as systemic sclerosis, lupus or eosinophilic fasciitis. * uncontrolled diabetes or known diabetic complications of gastroparesis, neuropathy or nephropathy. * taking opioid agents in the 2 weeks prior to screening and throughout the study. * history of strictures in the small bowel or stomach (e.g., pyloric stenosis) or gastric surgeries or procedures such as pyloromyotomy, pyloric dilation, pyloric resection, vagotomy, bariatric surgery or post-nissen fundoplication or antrectomy with billroth i, billroth ii or roux-en-y gastrojejunostomy. * past or current medical problems or findings such as: advanced liver disease (child's b or c), acute or chronic renal disease (serum creatinine \> 3 mg/dl), neurologic disease (e.g., dysautonomia), achalasia and adrenal insufficiency.

Keywords: gastritis eosinophilic gastrointestinal disorders gastric dysfunction gastric dysmotility eosinophils eosinophilia eosinophilic disorders digestive system diseases immune system diseases stomach diseases gastric emptying scintigraphy endoscopy
clinical determinants of the 6 minute walk test in cerebral palsy

Conditions: Cerebral Palsy; Exercise

Summary: cerebral palsy (cp) is a group of permanent disorders of movement and posture, generally accompanied by secondary musculoskeletal problems. studies in literature showed taht children with cp supports a link between the levels of impairment and walking ability. the 6 minute walk test is a standardized, self-placed walking test commonly used to access functional ability in children with cerebral palsy. while decreased exercise capacity has been identified in children with cerebral palsy, the clinical determinants of the 6mwt in this population have not been investigated yet. thus the aim of this study is to investigate the relationship between 6 minute walk test, quality of life, respiratory muscle strength,activities of daily living using with pediatric evaluation of disability inventory and trunk control.

a convenience of children with hemiparetic and diplegia cp, 7-14 years, is going to recruited from gazi university, faculty of health science, department of physiotherapy and rehabilitation. every each of patients respiratory muscle strength will be evaluated using with electronic mouth pressure device, trunk control with using trunk control measurement scale, activities of daily living using with pediatric evaluation of disability inventory (pedi), functional exercise capacity usin with six minute walk test (6mwt) and quality of life using with cerebral palsy quality of life questionnaire (cpqol).

Eligibility criteria:
inclusion criteria: * aged 7-14 years * diagnosed to spastic cerebral palsy * gross motor function classification system levels i or ii. * have no earlier interventions in the form of orthopaedic surgery or injection with botulinum toxin type a in the 6 month prior to baseline assessments * child are able to demonstrate sufficient co-operation and cognitive understanding participating exclusion criteria: * active medical condition impairment (pneumonia etc.) * do not accommodate the study * do not want to attempt the study

Keywords: cerebral palsy functional exercise capacity quality of life
a rct of ondansetron and promethazine in the treatment of nausea and vomiting in the emergency department

Conditions: Nausea; Vomiting

Summary: this was a trial comparing two commonly used medications for nausea and vomiting, ondansetron and promethazine, in the emergency department.

nausea and vomiting are common complaints in the emergency department (ed). there are many pharmacologic agents used for the treatment of these complaints. none are new nor experimental. very little research has been done in the ed setting to determine which of these agents is most effective with the least adverse effects. our own previous research found that droperidol but not prochlorperazine and metoclopramide is more effective than placebo. because of the recent fda black box warning added to droperidol, the use of this agent has suddenly ceased in many eds. promethazine remains a very commonly used antiemetic in many eds but one recent study found it less effective than prochlorperazine which was in turn found no more effective than placebo in our own study. as a result many physicians have turned to ondansetron, a newer and more expensive agent. experience among anesthesiologists and oncologists has shown ondansetron to be highly effective with a minimum of adverse effects. these patient populations, however, are very different from those found in the ed. it is our hypothesis that promethazine and ondansetron are equally effective for the ed treatment of unselected patients with nausea and vomiting with similar rates of adverse effects.

Eligibility criteria:
inclusion criteria: * age 18 or older * chief complaint of nausea or vomiting exclusion criteria: * age less than 18 * unable to provide informed consent * rate nausea at \< 40 mm on 100 mm vas * received antiemetic within 24 hours * pregnant or possibly pregnant * reported allergy to either study medication * received more than 1 liter of intravenous fluids * their primary ed physician declined to have patient participate

Keywords: nausea, vomiting, antiemetic
gmp powdered substitutes in pku and tyr

Conditions: Phenylketonuria; Tyrosinemia

Summary: four new gmp-based protein substitutes have been developed to support the dietary management of pku and tyr. these products are powdered protein substitutes, low in phenylalanine and low in phenylalanine and tyrosine respectively, with a mix of glycomacropeptide (gmp), essential and non-essential amino acids, carbohydrates, fibres, fats (including dha) and micronutrients. the proteins in these new protein substitutes are based on gmp, a peptide isolated from milk during cheese manufacturing and the only known naturally derived protein source low in phenylalanine and tyrosine. the gmp is supplemented with other amino acids which are naturally low or not present in gmp, as well as carbohydrates, fats, fibre and micronutrients. studies to date have illustrated that pku patients who replace their regular phenylalanine-free amino acid-based formula with gmp-based foods may have better diet compliance and prefer the taste whilst maintaining metabolic control. this series of case-studies aims to evaluate the gastrointestinal tolerance, acceptability, compliance, and safety of these four gmp based protein substitutes in both adults and children over 3 years. these case studies will last 29 days in total, including a 1-day baseline period followed by a 28-day intervention period. the case studies will be conducted across multiple specialist metabolic centres in the uk. a series of case studies is undertaken due to the rarity of these conditions, the diversity of patient types and the difficulty in recruiting these patients to trials.


Eligibility criteria:
inclusion criteria: * male or female * over 3 years of age * patients diagnosed with any phenotype of pku characterised by hyperphenylalaninaemia or patients diagnosed with tyrosinaemia * have been compliant in taking at least one protein substitute, providing at least 15g protein equivalents, for at least 1 month prior to trial commencement * have a prescribed daily phenylalanine or phenylalanine and tyrosine allowance for pku or tyr respectively * written or electronic informed consent from patient, and/or from parent/caregiver if applicable * participants who are anticipated to be able to take at least one sachet of gmp product per day exclusion criteria: * pregnant or lactating * requiring parenteral nutrition * major hepatic or renal dysfunction * participation in other studies within 1 month prior to entry of this study * allergy to any of the study product ingredients * investigator concern around willingness/ability of patient or parent/caregiver to comply with protocol requirement
danazol treatment in endometriosis women before ivf

Conditions: Endometriosis; Ovarian Cysts; Infertility

Summary: the purpose of this study is to determine whether pre-treatment with danazol for at least 4 months before controlled ovarian hyperstimulation for ivf cycles improves pregnancy rate.

endometriosis is a chronic benign disease defined by the presence of endometrial tissue outside the uterine cavity, affecting women in their reproductive age. this disease is clinically characterized by infertility pelvic pain and the presence of ovarian cysts, endometriomas, and affects the about 10% of women. women with endometriosis when undergo ivf show lower pregnancy rate than general population, and a reduced ovarian reserve, due to the diseases and often to ovarian surgery. the aim of this study is to evaluate if a pre-treatment with danazol, an anti-estrogenic agent, may improve the otcome of ivf cycles in these women

Eligibility criteria:
inclusion criteria: - clinical diagnosis of endometriosis previous laparoscopic surgery for ovarian endometriotic cysts infertility exclusion criteria: - age more than 40 years systemic disease antimulleran hormone (amh)\ 20

Keywords: endometriosis ivf ovarian reserve danazol
hand hygiene practices and microbial contamination on feeding tubes and other components of feeding systems

Conditions: Enteral Nutrition; Microbial Colonization; Adherence

Summary: enteral feeding tube (eft) and component of feeding systems can serve as a reservoir of microorganisms, and the main reason is inappropriate hand hygiene practices. the aim of the project is to determine colonization of microorganisms on the eft and other components and assess the relation between colonization and adherence to hand hygiene practices by healthcare workers in the intensive care unit. this prospective, observational and semi-experimental study will be conducted in one year. the project will be completed with healthcare workers and 51 patients who are feeding enteral route via nasogastric tube at least for three days. the researchers will provide training to healthcare workers in accordance with the world health organization (who) hand hygiene guidelines. hand hygiene behaviors of the participants will be observed and the question forms will be filled before and after training by researchers. the samples for microbial analysis will be collected from the eft by sterile swaps.

enteral feeding tube (eft) such as nasogastric tube (ngt), duodenal/jejunal tube and gastrostomy tube are frequently used in intensive care unit (icu). however, eft is generally an omitted/neglected source of contamination. eft can serve as a reservoir of methicillin resistant staphylococcus aureus (mrsa), which multiplies the risk of mortality by 2-2.5 times, for microorganism transmission. as a consequence of contamination of eft, microorganisms, that may be manifest with the symptoms such as abdominal pain, distention, nausea, vomiting, diarrhea, may reproduce and progress to bacteremia, septicemia and even to death. in some studies, it is observed that there is a relation between the contamination on the external surface of eft and contamination on the entry of eft (hub), and it is also reported that the rate of contamination on the hub of the eft and the environment of the patient is quite high. icu nurses are responsible for sustaining safe and secure feeding, medication and fluid replacement of patients. also, they provide enteral feeding products to patients as they are prescribed. personnel training, proper processing procedures and developed enteral feeding protocols are shown to decrease the incidence of bacterial contamination on the enteral feeding tube

Eligibility criteria:
inclusion criteria: * patients who are 18 years old or older * being enteral fed via nasogastric tube at least for three days * patients' relatives approve to be enrolled are going to be included in the study * nurses and other healthcare providers who work in the icu exclusion criteria: * patients who are being under respiratory, contact or droplet isolation according to definitions of centers for disease control and prevention * patients' relatives do not approve enrollment
valvular heart disease registry

Conditions: Valvular Heart Disease

Summary: patients undergoing transcatheter valvular interventions will be prospectively included into the present registry. baseline, procedural and follow-up data will be collected and analyzed to adress various issues in the field of percutaneous valvular interventions.


Eligibility criteria:
inclusion criteria: - severe valvular defect planned for valvular intervention exclusion criteria: - no informed consent
qigong and exercise for neck pain in adults (qena)

Conditions: Chronic Neck Pain

Summary: the purpose of this study is to assess the effectiveness of qigong for the treatment of chronic neck pain compared to exercise therapy and waiting list group.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic neck pain since at least 6 months and complaints for a maximum duration of 5 years * neck pain more prominent than other pain in the spine * average pain intensity of the last 7 days more or equal to 40 mm measured by a visual analogue scale (vas 0 - 100 mm) * normal mobility of the cervical spine * intellectual and physical ability to participate in the study * informed consent exclusion criteria: * cervical pain related to malignancy * cervical pain due to an accident * inflammatory joint disorders * previous spine surgery * protrusion/prolapse of a spinal disk, spondylolisthesis, with radicular symptomatology * actually doing or planning to do other regular physical exercise during the study with possible positive effects on neck pain - such as swimming, yoga, pilates, tai chi, etc. * use of pain drugs for other diseases (\> 1x/week) * pregnancy * severe chronic or acute disease interfering with therapy attendance * alcohol or substance abuse * participation in another clinical trial in the last 6 months before study entry

Keywords: qigong traditional chinese medicine exercise therapy neck pain
safety profile comparison of undiluted intracameral moxifloxacin vs. levofloxacin in cataract surgery

Conditions: Cataract

Summary: the goal of this randomized clinical trial study is to compare safety profile undiluted intracameral moxifloxacin vs levofloxacin during cataract surgery. the main question it aims to answer is whether moxifloxacin and levofloxacin have similar safety profile. participant will be randomized into two treatment arms. all participant will receive standardized treatment before, during, and after surgery and will be followed up at one day, one week, and one month after surgery.

this study aims to observe the safety profile in patient receiving cataract surgery who receives moxifloxacin and levofloxacin intracamerally during the surgery. safety profile defined as visual acuity, intraocular pressure, corneal endothelial cell density, central corneal thickness, anterior chamber reactions, and central macular thickness. parameters are obtained before the surgery, 1 day, 1 week, and 1 month after surgery. subjects are randomized to two treatment arms: (1) receiving undiluted moxifloxacin 0.1 cc during surgery; (2) receiving undiluted levofloxacin 0.1 cc during surgery.

Eligibility criteria:
inclusion criteria: * immature senile cataract in one or both eye * agree to be included and signed informed consent exclusion criteria: * have a history of allergy to moxifloxacin or levofloxacin or any other antibiotics * other ocular comorbid such as uveitis, glaucoma, diabetic retinopathy, pseudoexfoliation, and endothelial disorders * ocular surgery prior to study * sign of infection or inflammation around the eye * cataract density more than grade 4 according to lens opacities classification system (locs) iii grading * corneal endothelial cell density \< 1500 cell/ mm2 * anterior chamber depth \< 2.5 mm * diabetes mellitus type 2

Keywords: moxifloxacin levofloxacin cataract surgery