Kornimate/medical-research-clean huggingface dataset:
self and body perception in otoneurological disorders: translation and validation of measurement scales

Conditions: Patients With Acute or Chronic Otoneurological Disorders; Patients Presenting or Having Experienced Dizziness and / or Balance Disorders

Summary: depersonalization-derealization (dd) disorders are a clinical phenomenon characterized by feeling disconnected or detached from one's self. individuals may report feeling as if they are an outside observer of their own thoughts or body, and often report feeling a loss of control over their thoughts or actions. several scales have been developed to measure dd, and the cambridge depersonalization scale (cds) appears to be the most relevant and consistent to characterize the clinical symptoms of these disorders as well as their duration and frequency. this scale, originally written in english, must be translated and validated according to standardized methods that include testing steps patients with dizziness and in individuals with no vestibular disorder. persistent postural-perceptual dizziness (pppd) is a chronic, persistent vestibular syndrome generally preceded by acute vestibular disorders. the main symptoms are rotational dizziness, unsteadiness and / or non-rotating dizziness that are exacerbated by upright posture, walking, active or passive movement, and exposure to moving visual stimuli or complex visual patterns. to help diagnose this syndrome, a questionnaire was developed in japan in 2019, the niigata questionnaire, however no french version has yet been validated. similarly, this scale needs to be validated in patient with pppd and in control populations. the main objective of this study is to validate the french translation of these two scales, the cds questionnaire and the niigata pppd questionnaire, according to standard methods (forward translation, back translation, consensus).


Eligibility criteria:
inclusion criteria: for patient: * age ≥ 18 years * patient with acute or chronic otoneurological disorders * patient having or having experienced dizziness and / or balance disorders * patient with pppd * fluency in french * having given free and informed written consent * being affiliated with or benefiting from social security for control subjects: * age ≥ 18 years * fluency in french * having given free and informed written consent * being affiliated with or benefiting from social security. exclusion criteria: for patient: -past or present psychiatric and neurological disease (other than otoneurological or pppd, as declared by the participant) for control subjects: -past or present psychiatric and neurological disease (as declared by the participant) and vestibular and/or auditory system disorders (as declared by the participant) for all participants: * persons still in a period of exclusion from another study and persons simultaneously participating in another study * subject to a measure for the protection of justice
the effects of a spread with added plant sterols and omega-3 fatty acids on blood lipids

Conditions: Vascular Diseases; Hypercholesterolemia

Summary: the main aim of the study is to investigate the effect of daily consumption of a margarine enriched with plant sterol esters and fish oil on fasting triglycerides (tg) concentrations. the study also aims to investigate the effect of plant sterols and fish oil on fasting total cholesterol (tc), low-density lipoprotein cholesterol (ldl-c), high-density lipoprotein cholesterol (hdl-c) and non-hdl-c. at last, the effect of plant sterols and fish oil on fasting apolipoprotein concentrations will be explored.

the main aim of the study is to investigate the effect of daily consumption of a margarine enriched with plant sterol esters and fish oil on fasting tg concentrations. the study also aims to investigate the effect of plant sterols and fish oil on fasting tc, ldl-c, hdl-c and non-hdl-c. at last, the effect of plant sterols and fish oil on fasting apolipoprotein concentrations will be explored. this exploratory objective will only be analyzed if a relevant treatment effect on fasting triglycerides concentrations is observed.

Eligibility criteria:
inclusion criteria: * fasting tg levels at screening: ≥ 1.40 and ≤ 5.60 mmol/l * fasting ldl-c levels at screening: ≥ 3.4 and ≤ 4.9 mmol/l exclusion criteria: * recently (\<6 months) diagnosed with cardiovascular event(s), revascularization or systemic inflammatory conditions. * medical history which might impact study measurements, to be judged by the study physician * use of over-the-counter and prescribed medication which may interfere with study measurements * reported weight loss or gain of 3 kg or more during a period of 2 months prior to screening. * currently smoking or being a non-smoker for less than 6 months and reported use of any nicotine containing products in the 6 months prior to screening and/or during the study.

Keywords: plant sterols fish oil blood lipids
nonalcoholic fatty liver disease in taiwanese children

Conditions: Fatty Liver

Summary: nonalcoholic fatty liver disease (nafld) is an emerging and important disease in taiwan. however, the prevalence and clinical characteristics have not been studied well. the purpose of this study is to resolve the aforementioned problem.

\[study subjects\] obesity was defined as the bmi value \> 95 percentile by different age- and gender groups according to the standards of the department of health in taiwan. \[data collection\] the following data were obtained for each subject: age, gender, bmi, waist and hip circumference. bmi was calculated as body weight (kg)/ height (m2). in fasting venous blood samples, we measured total serum bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, fasting glucose, triglyceride, total cholesterol,high-density lipoprotein cholesterol, insulin, glucose, and adiponectin. \[liver ultrasonography\] all participants underwent an ultrasonographic study of the liver performed by one operator. nafld was defined as the presence of an ultrasonographic pattern consistent with the following criteria: liver-kidney echo discrepancy, attenuated echo penetration and visibility of diaphragm, and obscure hepatic vessel structures.

Eligibility criteria:
inclusion criteria: * diagnosis of fatty liver exclusion criteria: * other hepatic diseases
stress, anxiety, and mood group therapy

Conditions: Depressive Disorders; Anxiety Disorders

Summary: the purpose of this study is to identify cognitive mechanisms that might facilitate treatment response for individuals experiencing depression and/or anxiety. the stress, anxiety, and mood group helps individuals experiencing symptoms of stress, anxiety, and mood by providing concrete coping skills to regulate emotions, to let go of negative thoughts, and build courage to talk to others about tough topics. groups meet for 8 weeks, with sessions lasting 90 minutes each. in addition to group therapy, you will be asked to complete some computerized and paper and pencil-based tasks. if you are interested in learning more, please contact us at 650-417-2000 ext. 3642 or paloalto.study@gmail.com. all inquiries will be kept strictly confidential.

primary objectives: i. identify specific patterns of executive function impairment that distinguish affective and cognitive symptoms in anxious and/or depressed patients. ii. identify specific components of executive function that predict unified protocol treatment response. this will set up subsequent cognitive intervention studies targeting those components. the phone screen includes a confidentiality statement explaining how their information will be kept confidential, demographic questions, and questions regarding the participants' medical and psychiatric history, and current psychological state. responses to these questions will be used to determine if the individual meets inclusion criteria to engage in the study. if the participant meets study eligibility criteria, he/she will be invited to an informational session not exceeding two and a half hours at dr. warren's lab, which involves an explanation the project, informed consent, some questionnaires, and a diagnostic clinical interview. also during the first visit, participants will be informed of the upcoming visits and the types of activities they will be asked to engage in for the purposes of this study. during a second visit, subjects will undergo cognitive testing designed to measure set shifting, working memory updating, cognitive inhibition, processing speed, general intelligence, and attentional control. these tests will be administered at dr. warren's lab and will not exceed two and a half hours. the remainder of the study visits will involve an 8-week, cognitive-behavioral group therapy titled "unified protocol," to take place at the gronowski clinic. treatment groups will be facilitated by dr. warren and co-facilitated by trained graduate students selected by dr. warren.

Eligibility criteria:
inclusion criteria: * normal color vision * ability to travel to palo alto university * experiencing symptoms of stress, anxiety, and/or depression

Keywords: depression anxiety
oral steroid treatment for chronic rhinosinusitis

Conditions: Chronic Rhinosinusitis

Summary: despite the common use of oral steroids in the management of chronic rhinosinusitis (crs), the natural history and efficacy of this treatment modality has not been fully elucidated. specifically, patients who have undergone prior ess and have recalcitrant crs, the natural history of endoscopic improvement and quality of life (qol) outcomes, following an oral steroid taper, is poorly defined. the purpose of this non-randomized single-arm clinical trial is to evaluate the effectiveness of an oral steroid taper in improving endoscopic grading, qol, and olfactory function as well as defining the duration of improvement, in patients with recalcitrant crs with prior endoscopic sinus surgery (ess).


Eligibility criteria:
inclusion criteria: * adult ( \> 18 years of age) * crs defined by 2007 adult sinusitis guidelines.12 * subject must be able to complete qol questionnaires written in english * previous sinus surgery including unilateral or bilateral total ethmoidectomy * minimum nasal blockage score on sinonasal outcomes test-22 (snot-22) \> 3 * severe sinonasal inflammation where the next treatment option is a 12- day oral prednisone taper * obstruction of the ethmoid sinus region or middle meatus eligible for revision endoscopic sinus surgery * lund-kennedy endoscopy score \> 4 * elects 12-day tapering dose of oral steroids (prednisone) as a next treatment option exclusion criteria: * unable to complete questionnaires or clinical testing or cooperate with study evaluations in english * contra-indication to oral steroids * endoscopic sinus surgery \< 3 months of presentation * completed course of oral corticosteroids within the previous 3 month period * subjects presenting with unilateral chronic rhinosinusitis * pregnancy or possibility to become pregnant during the study

Keywords: chronic sinusitis steroid treatment
multimodality prediction of success of atrial fibrillation rhythm control strategy

Conditions: Atrial Fibrillation

Summary: in this study the investigators aim to build a model to predict the maintenance of sinus rhythm (sr) after successful direct current cardioversion (dcc) incorporating standard predictors such as echocardiographic parameters, clinical parameter and 12-lead ecg parameters and new parameters, including 17-lead ecg, oesophageal-ecg and single nucleotide polymorphisms (snps). using this novel integrated prediction model will help in the identification of patients who will maintain sr after cardioversion. another innovative aspect of our study is the use of daily rhythm monitoring using a versatile device (mydiagnostick®). the clinical impact this study will have is that it helps the cardiologist to make a patient tailored strategy in the treatment of af as advocated by the guidelines and to prevent exposing patients not likely to maintain sr to the potentially harmful side-effect of a rhythm-control strategy. primary objectives to show that a model incorporating the novel predictors 17-lead ecg, oesophageal-ecg and snps is superior to existing models in predicting maintenance of sinus rhythm after successful dcc in patients with persistent af. secondary objectives to assess the predictive value of new predictors (the oesophageal-ecg, 17-lead ecg and snps) for maintenance of sr after successful dcc separately. to assess the predictive value of new predictors (the oesophageal-ecg, 17-lead ecg and snps) for time to recurrence of af. to assess the predictive value of predictors with respect to complete failure of cardioversion. to assess the predictive value of predictors with respect to cardiovascular morbidity. hypothesis the investigators hypothesise that a model incorporating the novel predictors the 17-leads ecg, oesophageal-ecg and snps performs significantly better than existing models using only clinical, echocardiographic and ecg parameters on a standard 12-lead ecg in predicting maintenance of sr after successful dcc. in addition the investigators hypothesise that oesophageal-ecg is the best single predictor for maintenance of sr after successful dcc.


Eligibility criteria:
inclusion criteria: * haemodynamic stable patients with persistent af scheduled for dcc. * written informed consent. * patients \> 18 years old. exclusion criteria: * atrial flutter at time of dcc. * patients with known oesophageal disease. * patients with previous operations on throat or oesophagus. * postoperative atrial fibrillation. * patients with previous ablation for af. * previous inclusion in this study. * patients on anti-arrhythmic drugs (aad). * patients with pacemakers unable to detect af and with a regular paced rhythm during af. * planned ablation for af. * myocardial infarction within the last 4 weeks.
outcomes after weight loss surgery in low-risk patients

Conditions: Weight Loss; Bariatric Surgery

Summary: the purpose of this research is to determine patient-reported outcomes after weight loss surgery, including changes in health, mood, quality of life, health satisfaction, and emotional health, in low-risk patients. weight loss surgery has been well studied for patients with body mass index (bmi) 35 kg/m\^2 or more and those with weight-related medical problems who have a bmi 30 kg/m\^2 or more. however, outcomes after weight loss surgery in patients with bmi under 35 kg/m\^2 and without co-morbidities have not been well studied.

the purpose of this research is to determine patient-reported outcomes after weight loss surgery in low-risk patients. weight loss surgery has been well-studied for patients with body mass index (bmi) 35 kg/m\^2 or more and those with weight-related medical problems who have a bmi 30 kg/m\^2 or more. weight-related medical problems, also called co-morbidities, can include diabetes mellitus, hypertension, sleep apnea, and degenerative joint diseases. the surgery is considered safe and effective. outcomes after weight loss surgery in patients with bmi under 35 kg/m\^2 and without co-morbidities have not been well studied. the investigators' purpose is to study patient-reported outcomes after weight loss surgery in patients with bmi between 30 kg/m\^2 and 34.5 kg/m\^2 without co-morbidities. these include changes in health, mood, quality of life, health satisfaction, and emotional health.

Eligibility criteria:
inclusion criteria: * patients with bmi between 30 kg/m2 and 34.5 kg/m2 without co-morbidities who are medically cleared to undergo cosmetic weight loss surgery. * written informed consent obtained from the subject or the subject's legal representative and the ability for the subject to comply with the requirements of the study. exclusion criteria: * patients who are pregnant. * patients with bmi below 30 kg/m2. * patients with bmi above 34.5 kg/m2. * patients who have co-morbidities including, but not limited to, diabetes mellitus, hypertension, sleep apnea, and degenerative joint disease. * patients who are not medically cleared to undergo weight loss surgery.

Keywords: outcomes
dipeptidyl peptidase-4 inhibitors and alpha-cell recovery

Conditions: Type 1 Diabetes; Hypoglycemia

Summary: hypoglycaemia is a well-known complication of insulin treated diabetes. the counterregulatory response to hypoglycaemia, with glucagon as the most important mediator, is initially diminished within a few years of onset of type 1 diabetes and subsequently lost and thus increasing the risk of hypoglycaemia. dipeptidyl peptidase (dpp)-4 inhibitors augment the glucagon response to insulin-induced hypoglycaemia in type 2 diabetes. the investigators hypothesize that treatment with a dpp-4 inhibitor in patients with type 1 diabetes will recover the alpha cell response to hypoglycaemia.

the 16 type 1 patients will be randomised to one of two treatment sequences: dpp-4 inhibitor followed by placebo or placebo followed by a dpp-4 inhibitor. each treatment period lasts 6 weeks, so all patients will receive treatment for 12 weeks in total. induction of hypoglycaemia will take place at 0 weeks, 6 weeks and 12 weeks to determine the glucagon response.

Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus 5-20 years duration * c-peptide negative * willing and able to give written informed consent exclusion criteria: * impaired awareness of hypoglycaemia * bmi \> 27 kg/m2 * evidence of severe diabetes complications (autonomic neuropathy, macroalbuminuria, proliferative retinopathy) * acute illness within 3 months before the study * significant renal impairment (creatinine clearance \< 50ml/min) * use of beta-adrenoreceptor blockers * cardiac history (previous arrhythmia) * history of epilepsy

Keywords: type 1 diabetes dpp-4 inhibitor glucagon
effectiveness of an interdisciplinary pain education program in public health: a pragmatic clinical trial

Conditions: Musculoskeletal Pain

Summary: the objective of this study is to evaluate the effectiveness of an interdisciplinary pain education program in improving self-efficacy and promoting quality of life in patients with chronic musculoskeletal pain in public health. this is a pragmatic clinical trial carried out with patients referred to the physical therapy sector of a municipality who will be allocated in an interdisciplinary pain education intervention group or a comparison group of conventional physical therapy treatment.

his is a pragmatic clinical trial carried out with patients referred to the physical therapy sector of a municipality who will be allocated in an interdisciplinary pain education intervention group or a comparison group of conventional physical therapy treatment. clinical characteristics of pain will be evaluated by multidimensional questionnaires, in addition to self-efficacy, quality of life, functional literacy and sociodemographic profile. health professionals will be evaluated by an attitude towards pain inventory. it is expected to demonstrate the effectiveness of interdisciplinary pain education work in managing the biopsychosocial impacts of pain by promoting knowledge and self-management strategies in the care of this chronic condition. as it is a light and collective technology, it can reduce the burden of the disease and support public policy decision-making in the management of chronic pain in public health.

Eligibility criteria:
inclusion criteria: * patients with a clinical picture of chronic musculoskeletal pain, aged over 18 years, being sus users referred for physiotherapy treatment. exclusion criteria: * patients with a clinical picture of acute pain, post-traumatic or post-surgical pain, cancer pain and neuropathic pain, as well as those with autoimmune diseases. patients with cognitive problems who cannot understand and respond to the questionnaires and who also have other physical disabilities unrelated to the chronic pain condition.

Keywords: health education self efficacy health-related quality of life functional health literacy
influence of knee alignment and pelvis rotation on accuracy of radiograph measurements before total knee arthroplasty

Conditions: Knee Osteoarthritis

Summary: the aim of this study is to determine the accuracy of long leg standing x-rays with respect to coronal alignment of the knee.

long leg standing x-ray is a routine examination to measure the femoral valgus angle before a total knee arthroplasty. newer studies have shown that coronal leg alignment influences the rotation of the distal femoral part. this rotation might influence the measurements obtained with a long leg standing x-ray. the primary purpose of this study is to determine whether there is a significant difference between 2d measurements taken on the x-ray and 3d measurements obtained with a ct scan.

Eligibility criteria:
inclusion criteria: knee osteoarthritis scheduled for knee arthroplasty exclusion criteria: * previous leg deformities or surgery that changes alignment

Keywords: knee aligment total knee arthroplasty coronal alignment of the lower limb x-ray accuracy
remote monitoring and social support for hypertension management

Conditions: Hypertension

Summary: a 3-arm randomized pilot trial aimed at comparing the effectiveness of different remote approaches to improving blood pressure (bp) control.

the investigators plan to leverage the way to health (wth) platform to develop and evaluate a new htn service-delivery model that is integrated with routine clinical care at penn family care (pfc), an academic family medicine practice in west philadelphia. among patients with poorly controlled htn: 1. the investigators will assess the effects of monitoring blood pressure and medication adherence with feedback to the patient and to the clinical practice, as needed if out of control. 2. the investigators will also compare the impact of providing feedback to a social support partner with facilitated cheerleading.

Eligibility criteria:
inclusion criteria: * between 18 and 75 years old with htn (icd-10 code i10) * has had at least two office visits at penn family care (pfc) within the past 12 months (at time of chart review), with at least two of the visits with bp readings exceeding htn guidelines, including the last visit (150/90 or 140/90 if ages 21-59 yrs with ckd or diabetes) * must have a cellular phone with texting capabilities * must be prescribed at least one medication for hypertension exclusion criteria: * has metastatic (stage iv) blood or solid tumor cancer * has end stage renal disease * has congestive heart failure * has dementia * has liver cirrhosis