Kornimate/medical-research-clean huggingface dataset:
smokers' quitline for asian language speakers

Conditions: Smoking Cessation

Summary: the study tested the effects of telephone counseling for smokers from three asian language speaking groups: chinese, korean, and vietnamese. the specific aims were to: 1) test the efficacy of a culturally appropriate counseling protocol for smokers calling the california smokers' helpline on the chinese, korean and vietnamese lines, 2) examine whether intervention effects varied by cognitive and behavioral predictors of cessation success, 4) examine whether family involvement plays a role in quitting success, and 5) assess differences in counseling effect across the three ethnic groups.

asian americans are among the least studied groups in smoking research, which has created a knowledge gap in understanding their behavior and in developing methods to help them quit. no efficacy data have been reported for telephone counseling of smokers who prefer to use asian languages, although telephone intervention holds promise for these groups because of its convenience and its potential to reach large numbers of smokers. in this two-arm design subjects are stratified by language (chinese, korean, and vietnamese) and randomized to telephone counseling (plus materials) or self-help materials only, which serves as the control. the study is significant in several ways. first, it provides timely information on a cessation approach for a traditionally under-served population (asian language speakers). second, effective telephone counseling can be widely applied because of the proliferation of quitlines with centralized services in recent years. third, by targeting asian language speakers this study addresses the issue of ethnic disparities, which has been identified by many (including the nci bypass budget) as a research priority.

Eligibility criteria:
inclusion criteria: * 18-75 years old, * daily smoker, * ready to quit within one month, * first time caller, * valid phone number, * valid address, * california (ca) resident, * gave consent to participate in study and evaluation, * called the chinese, korean or vietnamese line exclusion criteria: * used other form of tobacco, * major medical or psychiatric complication (e.g. lung cancer, major depressive disorder, anti-psychotic medicine, recent stroke, impending surgery)

Keywords: tobacco cessation smoking cessation telephone self-help smoking abstinence tobacco use disorder disparity
impact of e-learning on parental confidence in managing food allergy

Conditions: Food Allergy in Children; Food Allergy in Infants

Summary: education and dietary support are integral in managing food allergy in children. the study aim is to analyze the impact of e-learning on parental confidence in managing their child's food allergy.

food allergy is a common childhood morbidity, that has increased in prevalence over the last few decades. education and dietary support is integral in managing food allergy in children; however it is labor intensive and requires financial resources, which places an economic burden on the healthcare system. the study aim is analyze the impact of e-learning on parental confidence in managing their child's food allergy.

Eligibility criteria:
inclusion criteria: * legal caregivers of a child that is allergic (confirmed by an allergist) to at least one of the main food allergens (cow's milk, egg or wheat) and is following an elimination diet to at least one of these allergens. * internet access available. exclusion criteria: * participant non proficient in lithuanian.

Keywords: food allergy milk egg wheat children
does adding milk to coffee change gastric volume?

Conditions: Respiratory Aspiration of Gastric Content

Summary: the intention of this study is to determine wether coffee added milk change gastric volume in comparison with gastric volume after drinking black coffee

thirty participants - divided in tree groups - drink coffee with or without milk after six hours fast for solid food. each group drinks both coffee with or without milk in different order. two hours after drinking coffee gastric volume is measured by magnetic resonance imagining.

Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * former or present gastric history, pregnancy, claustrophobia, metal implants
lung impedetiometric modification in sbt and extubation failure

Conditions: Weaning Failure; Mechanical Ventilation Complication

Summary: weaning is the entire process aimed at liberating patients from mechanical ventilation and endotracheal intubation. weaning should be considered as early as possible in order to reduce the time spent in invasive mechanical ventilation (imv), which is associated with morbidity and mortality. to verify if patients are ready to be extubated, a spontaneous breathing trial (sbt) is performed. at this stage some clinical indices and objective parameters are evaluated, such as the breathing pattern, gas exchange, haemodynamic stability and patient's comfort. in case of sbt success, the patient can be extubated. however, a post-extubation respiratory failure can occur within the first 48 hours after extubation, thus making extubation unsuccessful. some patients considered at risk for post-extubation respiratory failure benefit from the application of non-invasive ventilation (niv) after extubation. early characterization of these patients is crucial to improve their clinical outcomes. electrical impedance tomography (eit) has been introduced in clinical practice as a non-invasive bedside monitoring tool to evaluate the aeration and ventilation of different lung regions. eit has been proposed to guide ventilator settings adjustments in critically ill patients and to monitor prolonged weaning. however, the potential of eit to assess sbt and after extubation in a general icu population has never been evaluated insofar. the present study aims to describe the modifications of lung aeration, ventilation and inhomogeneity occurring during sbt and after extubation in a general population of critically ill patients at the first sbt attempt.


Eligibility criteria:
inclusion criteria: * glasgow coma scale ≥8 * presence of clearly audible cough during suctioning with need for tracheal suctioning ≤2/hour * normal sodium blood values * core temperature \<38.5° during the previous 8 hours * arterial partial pressure of oxygen to inspired oxygen fraction (pao2/fio2) ≥200 mmhg, with a positive end expiratory pressure ≤5 cmh2o and fio2 ≤0.4 * stable cardiovascular status (i.e., hr ≤140 beats/min, sbp between 90 and 160 mmhg without need for vasopressin, epinephrine or norepinephrine infusion, or with dopamine or dobutamine infusion ≤5 mcg/kg/min) * cuff leak volume \>110 ml exclusion criteria: * major heart arrhythmias or cardiac ischemia * pneumothorax or emphysema * recent (1 week) thoracic surgery * presence of chest burns * pregnancy * inclusion in other research protocols
determination of the 90% effective dose of a sufentanil bolus in analgesia during lateral decubitus of mechanically ventilated patients

Conditions: Pain

Summary: mechanically ventilated patients experiencing pain are frequent in intensive care units (icu) however their treatment remains unclear. this prospective pharmacodynamic study relates to the analgesia of procedural pains. the primary objective was to determine the 90% effective dose (ed) of a sufentanil bolus to obtain a satisfactory analgesia (defined by a behavioral pain scale (bps) at 3 or 4) during lateral decubitus (ld) of mechanically ventilated patients. material and method. patients who, at rest before the 48th hour of mechanical ventilation, reach the objectives of bps at 3 or 4 and ramsay sedation score between 3 and 5, were included. during a 72h evaluation phase, bps was used to measure the efficiency of a bolus of sufentanil on the analgesia of the ld. the dose of this bolus was raised gradually every new ld until bps was at 3 or 4.


Eligibility criteria:
inclusion criteria: * 48th hour of mechanical ventilation * mechanical invasive ventilation * 48th hour midazolam sedation * behavioral pain scale (bps) at 3 or 4 * mechanical ventilation of 5 days duration exclusion criteria: * pregnant or breast-feeding woman * impossibility of evaluation of the bps tetraplegia, curare-link , post anoxic coma encephalic death * indication of deep conscious-sedation, malignant cranial trauma, toxic shock, acute respiratory distress syndrome * extra renal clearance ou people in hemodialysis * severe renal failure (creatinine clearance \<15ml/min) * severe hepatic failure * state of consciousness with impossibility to use self-assessment scale * body mass index \>35 ou \<18 * sufentanil midazolam paracetamol allergy or contraindication * guardianship or confirmed criminal subject who give his informed consent * morphinic other than sufentanil (morphine, alfentanil fentanyl, remifentanil, nalbuphine, codeine, buprenorphine) * antalgic other than sufentanil and paracetamol ( tramadol nefopam, ketamine, dextropropoxyphene, non steroidal anti-inflammatory drug ) * mao inhibitors

Keywords: mechanical ventilation midazolam ramsay sufentanil
effects of remote ischemic conditioning on cerebral hemodynamics in patients with ischemic stroke

Conditions: Acute Ischemic Stroke

Summary: the purpose of this study is to determine the impact of remote ischemic conditioning on cerebral hemodynamics in patients with ischemic stroke.

current studies have shown that remote ischemic conditioning can activate neuronal signals and humoral factors, increase cerebral perfusion and promote neurological recovery in patients with ischemic stroke.the purpose of this study was to investigate the effect of remote ischemic conditioning on cerebral hemodynamics in patients with acute ischemic stroke.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years, \<80 years, both sex; 2. patients with a clinically definite diagnosis of acute ischemic stroke who are able to commence ric treatment within 72 hours of stroke onset; 3. baseline national institute of health stroke scale (nihss) score\<25; 4. pre-onset modified rankin scale (mrs) score ≤ 1; 5. glasgow coma scale score ≥8; 6. signed and dated informed consent is obtained. exclusion criteria: 1. patients who have undergone thrombolytic therapy or endovascular therapy; 2. inability to cooperate sufficiently to complete the cerebral autoregulation examination (e.g., due to a condition such as agitation, drowsiness, arrhythmia, insufficient bilateral temporal bone windows, etc.) during the recording; 3. presence of other intracranial lesions, such as cerebrovascular malformations, cerebral venous thrombosis, tumors, and other brain lesions; 4. severe hepatic and renal dysfunction or failure; 5. patients with hematological disease, abnormal coagulation function, bleeding tendency, and platelet \<100×10\^9/l; 6. individuals who had contraindication of remote ischemic conditioning, such as severe soft tissue injury, fracture or vascular injury in the upper extremities, venous thrombosis in the acute or subacute stage of upper extremities, arterial occlusive disease, subclavian artery stenosis ≥ 50%, or subclavian steal syndrome; 7. pregnant or lactating women; 8. previous ric treatment or similar treatment; 9. patients with a life expectancy of less than 3 months or patients who are unable to complete the study for other reasons; 10. unwillingness to be followed up or poor treatment adherence; 11. individuals who are participating in other clinical studies, have participated in other clinical studies within 3 months prior to enrollment, or have participated in this research; 12. other conditions that the investigator considers inappropriate for enrollment.
association of non-alcoholic fatty liver disease and coronary artery disease

Conditions: Nonalcoholic Steatohepatitis (NASH)

Summary: this study will evaluate the association of non-alcoholic fatty liver disease and coronary artery disease. all patients presenting for coronary angiogram will receive the following examination: * transient elastography and controlled attenuation parameter using the fibroscan * blood examination including biochemical markers the results of non-invasive liver steatosis and fibrosis measurement are compared with the results of coronary angiogram concerning the presence or absence of coronary artery disease.


Eligibility criteria:
inclusion criteria: * male or female, 18 years and older * written consent * coronary angiogram planned exclusion criteria: * patients with mental diseases * pregnancy or lactation * ascites

Keywords: nash; coronary artery disease
observational study evaluate pathology practice use artificial intelligence in patient suspected lung and breast cancer

Conditions: Lung Cancer; Breast Cancer

Summary: a multinational observational study to evaluate the current pathology practices and the utilization of computational pathology plus artificial intelligence algorithms in patients with suspected lung and breast cancer.

a non-interventional study evaluating samples from patients with suspected non-small lung cancer or breast cancer to describe pathology practices and to evaluate computational pathology plus artificial intelligence algorithms in australia, brazil, egypt, and kenya. use of digital and computational artificial intelligence pathology in countries with low and high pathologist/population ratios is critical in developing a sustainable solution. the study has two parts, the first part will focus on breast cancer, and the second part will focus on lung cancer. the laboratories have an active digital pathology setting and evaluate samples for cancer diagnosis. the centres of lung cancer part of the study will be selected at a later stage. the study will retrospectively evaluate samples from patients who have been preliminarily diagnosed with breast or lung cancer through clinical assessments and whose samples were evaluated only by using conventional workflow. as part of the study, computational ai pathology algorithms will be implemented in each laboratory. two ai pathology algorithms will be used in the breast cancer part of the study. galen™ breast application developed by ibex medical analytics will be implemented in a laboratory in australia. mindpeak breast, developed by mindpeak gmbh will be implemented in laboratories in brazil, egypt, and kenya. after implementing computational ai pathology algorithms, 150 samples evaluated for the primary objective from each laboratory for each cancer type will be evaluated using a conventional workflow plus an ai assisted workflow with human supervision and a conventional workflow plus an ai-assisted workflow without human supervision. these evaluations will be used to analyse secondary and exploratory objectives.

Eligibility criteria:
inclusion criteria:sample from adult patients (≥ 18 years) with suspected non-small cell lung cancer or invasive breast cancer or ductal carcinoma in situ. - exclusion criteria: * samples with the inadequate technical quality of slides (pre-analytics quality) or images, e.g., broken slides, large out-of-focus areas, slides with fixation artefacts. * samples from cases that were included in the training or technical validation. * sample taken by fine needle aspiration. * sample sent for cytological evaluation.

Keywords: artificial intelligence computational pathology algorithm positive predictive value negative predictive value galen™ breast application mindpeak gmbh laboratories
predicting response to vedolizumab in pediatric inflammatory bowel diseases

Conditions: Crohn's Disease; Ulcerative Colitis; Inflammatory Bowel Disease

Summary: vedolizumab (vdz) is a humanized immunoglobulin g1 monoclonal antibody acting against α4β7 integrin which modulates lymphocyte trafficking in the gut. results from the adult gemini-1 and gemini-2 trials demonstrated clinical efficacy in induction and maintenance of remission in both ulcerative colitis (uc) and crohn's disease (cd), respectively. recent real life cohorts in adults support the effectiveness of vdz in inducing and maintaining remission, both in cd and uc. in pediatrics, there are very limited data on the use of vdz besides two retrospective case series. data on immunogenicity and therapeutic drug monitoring (tdm) of vdz is conflicting in adults and practically non-existent in children. the investigators aim to prospectively explore the real life short and longer term outcomes of vdz in pediatric ibd (including growth) and to develop a prediction model for treatment success based on vdz trough levels and other clinical and laboratory variables.

this is a multi-center prospective cohort study in which the investigators are aim to enroll 140 children under the age of 18 years, diagnosed with cd, inflammatory bowel disease unclassified (ibdu) or uc (approximately 70 in uc/ibdu and 70 in the cd group) who commenced on vedolizumab for any reason at the discretion of the treating physician. patients will be followed up to 3 years at 8 different time points: week 0, week 2, week 6, week 14, week 30, week 54 (1 year), week 108 (2 years) and week 162 (3 years). blood work will be collected at each visit during the time of venous access insertion for the drug infusion for serum and stool sample will be collected at visits 0, 14, 30, and 54. in addition, at week 0 and 14 whole blood will be collected into a paxgene tube for gene expression analysis.

Eligibility criteria:
inclusion criteria: 1. children under the age of 18 years. 2. ibd diagnosis 3. initiating vedolizumab therapy exclusion criteria: 1. starting vedolizumab to prevent post operative recurrence

Keywords: vdz: vedolizumab uc: ulcerative colitis cd: crohn's disease tdm: therapeutic drug monitoring
effects of parathyroidectomy on cardiovascular risk factors in primary hyperparathyroidism

Conditions: Primary Hyperparathyroidism

Summary: primary hyperparathyroidism (phpt) is associated with increased cardiovascular morbidity. the benefit of surgical treatment in this respect is unclear. this study was performed to evaluate the impact of parathyroidectomy (ptx) on cardiovascular risk profile.

patients with primary hyperparathyroidism (phpt) have been shown to have an increased morbidity and mortality mainly due to cardiovascular disease. the precise mechanism of cardiovascular disease in phpt is not well understood and probably multifactorial. functional or structural alterations of vascular endothelial and smooth muscle cells may impair the vascular reactivity and lead to accelerated atherogenesis. several cardiovascular risk factors such as obesity, hypertension, insulin resistance and hyperlipidemia are more prevalent in phpt compared with controls.patients with severe form of phpt had a greater probability of metabolic syndrome (ms) and insulin resistance than patients with mild phpt and eucalcemic subjects. although the excess in cardiovascular mortality is significantly and independently related to serum calcium, the connection between the biochemical disturbances and the cardiovascular disorders in phpt patients is not necessarily a cause-and-effect relationship. indeed, the impact of surgical cure of hyperparathyroidism on cardiovascular risk factors and mortality is controversial. some studies suggest that hypertension, dyslipidemia, and derangement of glucose metabolism improve after removal of overactive parathyroid tissue. others have shown that cardiovascular risk markers remained unaltered after parathyroidectomy (ptx). the aim of this study was to evaluate whether successful ptx is associated with decreased cardiovascular risk. we investigated indices of metabolic syndrome and insulin resistance as well as various cardiovascular risk factors in patients with manifest phpt before and one year after successful ptx.

Eligibility criteria:
inclusion criteria: * patients with primary hyperparthyroidism exclusion criteria: * individuals with known diabetes mellitus,coronary heart disease, stroke
power during functional tasks in older adults

Conditions: Aging

Summary: the primary aim of this study is to optimize the methodology to measure lower limb power in older adults, so that clinicians are able to detect functional problems in this population earlier.

aging is associated with slower movement patterns, a higher fall risk and a restriction in functionality. this will lead to an increase in the number of dependent elderly and a high socio-economic burden. from the age of 40, a systematic loss of muscle mass and muscle force, also known as sarcopenia, will occur. in addition, performing daily tasks requires the production of muscle force at a certain speed. the product of force and speed, power, decreases even earlier and faster than muscle force. this power is typically measured with specialized equipment, which limits the large-scale applicability. with the help of accelerometry there is the possibility to measure power during more functional tasks and movements, which benefits the applicability, but the reliability, reference values and link with other outcome measurements related to sarcopenia has to be investigated.

Eligibility criteria:
inclusion criteria: * age \>20 exclusion criteria: * unstable cardiovascular diseases * fever or acute infection * cognitive or physical malfunctioning that hinders the understanding or performance of tests and/or instructions

Keywords: muscle power functional capacity
predictive value of the optic nerve involvement in clinically isolated syndrome

Conditions: Clinically Isolated Syndrome; Multiple Sclerosis

Summary: optic neuritis (on) represents around 30% of clinical presentation of clinically isolated syndrome (cis). asymptomatic optic nerve involvement is very frequent in all stage of multiple sclerosis (ms) disease including the cis. however, optic nerve is still not part of ms diagnosis criteria. the main objective of our regional and multicenter study is to evaluate the prognostic value of optic nerve involvement at the earliest clinical stage of ms (=cis) for the diagnosis of clinically definite ms (2nd clinical relapse) and the delay until the 2nd relapse.


Eligibility criteria:
inclusion criteria: * patients between 18 and 55 years old * occurrence of cis ≤ 6 months * with two t2 hypersignals on brain/spinal cord mri suggestive of ms or with oligoclonal bands * giving their written informed consent exclusion criteria: * pathological conditions that may skew the optic nerve mri and/or retinal oct (diabetes mellitus, glaucoma, retinopathy, ametropia \>6 dioptria) * past history of ms relapses * extensive myelitis (\>3 vertebral bodies) * bilateral optic neuritis without t2 lesions suggestive of ms * contra-indication to mri, gadolinium injection * pregnancy, breast-feeding * patients unable to consent

Keywords: clinically isolated syndrome multiple sclerosis mri optical coherence tomography optic nerve diagnostic criteria
alternate day buprenorphine administration, phase ix - 14

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to determine if four times a subjects' daily maintenance dose will hold for 120 hours without changes in agonist and antagonist effects.


Eligibility criteria:
please contact site for information.
effects of brassica or indole-3-carbinol on prostatectomy patients with psa recurrence

Conditions: Biochemical Failure

Summary: pilot and feasibility diet and phyto-agent intervention among healthy men at risk for prostate cancer progression.


Eligibility criteria:
inclusion criteria: * men with psa recurrence following prostatectomy exclusion criteria: * not using exogenous hormones

Keywords: psa biochemical failure