cardiac magnetic resonance imaging in patients with non-hodgkin lymphoma or hodgkin lymphoma receiving doxorubicin

Conditions: Cardiac Toxicity; Chemotherapeutic Agent Toxicity; Lymphoma

Summary: rationale: diagnostic procedures, such as cardiac magnetic resonance imaging, may help doctors detect early changes in the heart caused by chemotherapy. purpose: this clinical trial is studying how well cardiac magnetic resonance imaging works in patients with newly diagnosed non-hodgkin lymphoma or hodgkin lymphoma receiving doxorubicin.

objectives: * to determine whether early myocardial structural and functional changes can be detected using cardiac mri in patients with newly diagnosed non-hodgkin lymphoma or hodgkin lymphoma receiving doxorubicin hydrochloride-based chemotherapy. outline: patients undergo cardiac mri with gadolinium contrast prior to initiation of doxorubicin hydrochloride-based chemotherapy and 3 months after completion of six courses of chemotherapy for non-hodgkin lymphoma and twelve courses of chemotherapy for hodgkin lymphoma.

Eligibility criteria:
inclusion criteria: * diagnosis of non-hodgkin lymphoma or hodgkin lymphoma o newly diagnosed disease * planning to receive doxorubicin hydrochloride-based chemotherapy solely at the university of nebraska medical center * fertile patients must use effective contraception * able to lie flat for 90 minutes * able to fulfill the requirements of the study exclusion criteria: * not pregnant or nursing * no pacemaker * no chronic kidney disease stages 3-5 (glomerular filtration rate \< 60 ml/min) * no metallic foreign body not approved for mri * no known hypersensitivity to gadolinium contrast or other required drugs in the study * no comorbidity or condition which, in the opinion of the investigator, may interfere with the assessments and procedures of this study * no prior chemotherapy * no prior radiotherapy to mantle or mediastinum

Keywords: chemotherapeutic agent toxicity cardiac toxicity stage i adult hodgkin lymphoma stage ii adult hodgkin lymphoma stage iii adult hodgkin lymphoma stage iv adult hodgkin lymphoma stage i adult t-cell leukemia/lymphoma stage ii adult t-cell leukemia/lymphoma stage iii adult t-cell leukemia/lymphoma stage iv adult t-cell leukemia/lymphoma anaplastic large cell lymphoma angioimmunoblastic t-cell lymphoma cutaneous b-cell non-hodgkin lymphoma stage i mycosis fungoides/sezary syndrome stage ii mycosis fungoides/sezary syndrome stage iii mycosis fungoides/sezary syndrome stage iv mycosis fungoides/sezary syndrome stage i cutaneous t-cell non-hodgkin lymphoma stage ii cutaneous t-cell non-hodgkin lymphoma stage iii cutaneous t-cell non-hodgkin lymphoma stage iv cutaneous t-cell non-hodgkin lymphoma adult grade iii lymphomatoid granulomatosis adult nasal type extranodal nk/t-cell lymphoma waldenstrom macroglobulinemia contiguous stage ii adult burkitt lymphoma noncontiguous stage ii adult burkitt lymphoma stage i adult burkitt lymphoma stage iii adult burkitt lymphoma stage iv adult burkitt lymphoma contiguous stage ii adult diffuse large cell lymphoma noncontiguous stage ii adult diffuse large cell lymphoma stage i adult diffuse large cell lymphoma stage iii adult diffuse large cell lymphoma stage iv adult diffuse large cell lymphoma contiguous stage ii adult diffuse mixed cell lymphoma noncontiguous stage ii adult diffuse mixed cell lymphoma stage i adult diffuse mixed cell lymphoma stage iii adult diffuse mixed cell lymphoma stage iv adult diffuse mixed cell lymphoma stage i adult diffuse small cleaved cell lymphoma stage iii adult diffuse small cleaved cell lymphoma stage iv adult diffuse small cleaved cell lymphoma contiguous stage ii adult immunoblastic large cell lymphoma stage i adult immunoblastic large cell lymphoma stage iii adult immunoblastic large cell lymphoma stage iv adult immunoblastic large cell lymphoma contiguous stage ii adult lymphoblastic lymphoma noncontiguous stage ii adult lymphoblastic lymphoma stage i adult lymphoblastic lymphoma stage iii adult lymphoblastic lymphoma stage iv adult lymphoblastic lymphoma contiguous stage ii grade 1 follicular lymphoma noncontiguous stage ii grade 1 follicular lymphoma stage i grade 1 follicular lymphoma stage iii grade 1 follicular lymphoma stage iv grade 1 follicular lymphoma contiguous stage ii grade 2 follicular lymphoma noncontiguous stage ii grade 2 follicular lymphoma stage i grade 2 follicular lymphoma stage iii grade 2 follicular lymphoma stage iv grade 2 follicular lymphoma contiguous stage ii grade 3 follicular lymphoma noncontiguous stage ii grade 3 follicular lymphoma stage i grade 3 follicular lymphoma stage iii grade 3 follicular lymphoma stage iv grade 3 follicular lymphoma contiguous stage ii mantle cell lymphoma noncontiguous stage ii mantle cell lymphoma stage i mantle cell lymphoma stage iii mantle cell lymphoma stage iv mantle cell lymphoma nodal marginal zone b-cell lymphoma splenic marginal zone lymphoma contiguous stage ii marginal zone lymphoma noncontiguous stage ii marginal zone lymphoma stage i marginal zone lymphoma stage iii marginal zone lymphoma stage iv marginal zone lymphoma contiguous stage ii small lymphocytic lymphoma noncontiguous stage ii small lymphocytic lymphoma stage i small lymphocytic lymphoma stage iii small lymphocytic lymphoma stage iv small lymphocytic lymphoma