Kornimate/medical-research-clean huggingface dataset:
smartphone flicker fusion test for patients with optic disorders.

Conditions: Scotoma

Summary: the purpose of this project is to validate a quick, easy-to-use and administer smartphone flicker fusion test. the app (called eyefusion) can potentially be used to easily and quickly collect critical flicker fusion measurements on patients admitted with optic disorders as part of the clinical care process.

the smartphone app developed is a flicker fusion that presents the subject with a series of stimuli consisting of a flickering pattern of bars above or below a static rectangle. for each stimulus presentation, the user has to tap the region that is flickering. the duration of the app is less than 2 minutes. this study will assess the validity of the test construct in measuring flicker fusion thresholds, and serve as a foundation for further iterative designs of the app and future validation and characterization studies.

Eligibility criteria:
inclusion criteria: control * age matched 18-80 years of age. * healthy normal controls with no known eye disorders. exclusion criteria: * scotoma or any other ocular disorder inclusion criteria - patients * age 18-80 * clinically associated scotoma exclusion criteria - patients -any other ocular disorder
evaluation of cesarean scar after three different uterine closure technis

Conditions: Cesarean Section, Repeated; Cesarean, Uterine Scar Thickness; Cesarean, Residual Myometrial Thickness

Summary: the study compares three techniques of uterine closure on myometrium thickness at the site of uterine scar of women who underwent repeated cesarean section. cesarean scar will be evaluated by transvaginal ultrasound six months after cesarean.


Eligibility criteria:
inclusion criteria: * previous two or three cesarean * gestational weeks \>=36 weeks exclusion criteria: * risk of obstetric haemorrhage * suspicion or diagnosis placenta previa or accrete syndrome * chorioamnionitis * uterine myoma in the anterior uterine segment * hysterotomy other than lower segment uterine incision at previous cesarean
asthma care with alvesco® (ciclesonide) in primary care in adults - the accept-study (by9010/ca-102)

Conditions: Asthma

Summary: the purpose of this study is to investigate the effectiveness of alvesco® (ciclesonide) compared with usual asthma care in the primary care setting. patients with a history of asthma for at least 6 months and who, in the opinion of the physician, meet the clinical requirements for treatment with inhaled steroids (ics) will be enrolled. they will either receive alvesco® or usual care.


Eligibility criteria:
main inclusion criteria: * written informed consent * 18 years or older with diagnosis of asthma for at least 6 months * clinically stable asthma at the time of study enrollment * clinical requirements for treatment with ics as outlined in the canadian asthma consensus guidelines * if patients are currently on ics, the dose must be stable for 3 months and they must be willing to switch main exclusion criteria: * on combination therapy (ics + long acting beta-2-agonist) for asthma in the past 3 months or require combination therapy * severe asthma, one or more asthma exacerbations in the last 3 months requiring hospitalization or emergency room visit, or patients who have used systemic steroids more than 3 times in the past 6 months or who are currently using systemic steroids * mild asthma requiring short acting beta-2-agonists only * patients with a contraindication to ics therapy * any other disease or medical condition requiring further clinical evaluation, which in the opinion of the primary care practitioner may interfere with the clinical study or interfere with the diagnosis of asthma. * pregnancy, breast feeding, intention to become pregnant during the course of the study or lack of safe contraception in pre-menopausal women

Keywords: asthma alvesco® ciclesonide
the barf project: a pilot study using the barf scale to assess cinv in children

Conditions: Nausea

Summary: in this pilot study, the baxter retching faces (barf) scale will be used to assess chemotherapy induced nausea and vomiting (cinv) in the pediatric cancer population during chemotherapy admissions, and the corresponding administration of anti-emetic medications will be reviewed.


Eligibility criteria:
inclusion criteria: * patients diagnosed with cancer of any kind. * patients receiving inpatient chemotherapy at slch on the general pediatric oncology service * patients admitted for a course of inpatient chemotherapy scheduled to last at least 24 hours and but no more than 7 days. * patients who have received any prior cancer treatment, including radiation therapy, and/or surgery. * patients ages 4 to 12 years of age. * patient with a guardian who has the ability to understand english and the willingness to sign an irb approved written informed consent document. exclusion criteria: * any patient who is not undergoing inpatient chemotherapy on the general pediatric oncology service, including patients undergoing chemotherapy as conditioning for hematopoietic stem cell transplantation or other cellular therapy. * any patient who is receiving their first cycle of inpatient chemotherapy (however, they can be included during a future cycle). * any patient who is blind or unable to communicate by speaking or pointing.
effect of teas on the incidence rate of sirs in patients undergoing abdominal surgery

Conditions: Systemic Inflammatory Response Syndrome; Inflammation

Summary: the purpose of this study is to access the effect of transcutaneous electrical acupoint stimulation(teas) on the incidence rate of systemic inflammatory response syndrome (sirs) in patients undergoing radical surgery for gastric cancer

patients undergoing elective radical surgery for gastric cancer under general anesthesia were randomly assigned to three groups, control group , teas group and sham teas group. teas group receiving teas before general anesthesia induction , 1th day and 2nd day after surgery. teas was given through electrodes attached to specific acupoints. the time for teas was 30min. sham teas group receiving sham teas before general anesthesia induction , 1th day and 2nd day after surgery. sham teas was given through electrodes attached to non-acupoints. the time for sham teas was also 30min. control group were given no teas. incidence rates of sirs in each group were compared .venous blood samples from all groups(control group , teas group and sham teas group) were collected before general anesthesia induction,1th day and 3rd day after surgery. inflammatory cytokines index including interleukin-6,interleukin-10,tumor necrosis factor- alpha(tnf-α),interferon-γ(ifn-γ),monocyte chemotactic protein 1(mcp-1),igg,igm were measured.

Eligibility criteria:
inclusion criteria: * age\>30yrs,\<75yrs * asa 1-2 * scheduled for radical surgery for gastric cancer under general anesthesia； * informed consented exclusion criteria: * patients with implanted pacemakers * patients with severe hypertension or cardiac dysfunction； * patients with severe pulmonary disease * patients with hemoglobin\<90g/l
treatment of non-falciparum malaria

Conditions: Acute Non-falciparum Malaria

Summary: patients with non-falciparum infection will be given artemether-lumefantrine for three days and will be followed up for 28 days. besides efficacy and safety evaluations a substudy on immunology will be performed.


Eligibility criteria:
inclusion criteria: * male or female patients between the age of 6 months and 60 years and with a minimum of 5kg bodyweight * presence of uncomplicated malaria confirmed by: i)fever or history of fever in the previous 4 days, and ii)positive microscopy of p. malariae or p. ovale or mixed infection with p.falciparum with parasite density \> 50-200000/μl of blood * written informed consent exclusion criteria: * patients with presence of other clinical conditions requiring hospitalization * presence of other febrile conditions * presence of significant anemia, defined by hemoglobin \< 7g/dl * known history of hypersensitivity,allergic or adverse reactions to artemether or lumefantrine * intake of any antimalarial or antibiotics with known antimalarial activity in the preceding 2 weeks * pregnant and breast feeding females
effects of motor imagery and action observation training on pain perception in patients with chronic neck pain

Conditions: Pain, Chronic

Summary: this study evaluates the influence of motor imagery or action observation training on pain perception in patients with chronic neck pain. perception of pain will be measured by the pain pressure threshold. a group of patients will receive an action observation training of neck movements, another will receive a protocol of motor imagery of the same movements and the last group will be a placebo group, through the viewing of a documentary video.

motor imagery is defined as a dynamic mental process of an action, without its real motor execution. action observation training consists of watching an action performed by someone else. both motor imagery and action observation have been shown to produce a neurophysiological activation of the brain areas related to the planning and execution of voluntary movement in a manner that resembles how the action is performed in reality. both motor imagery and action observation are interventions that can generate adaptive neuroplastic changes on a cortical level, leading to a decrease in chronic pain. these rehabilitation techniques are used in pain treatment and impaired movement injuries that could be due to a nervous system alteration. the effectiveness of motor imagery is controversial; several studies have presented unfavorable outcomes from this technique. some variables, such as the duration of the sessions, the time employed the type of motor task or the number of sessions can influence the outcomes of these studies. thus, it is necessary to clarify the controversial aspects of motor imagery, which lead us to perform this study.

Eligibility criteria:
inclusion criteria: * men and women aged between 18 and 65 years * medical diagnosis of non specific chronic neck pain with more than 6 months of evolution of neck pain exclusion criteria: * patients with rheumatic diseases, cervical hernia, cervical whiplash syndrome, neck surgeries o a history of arthrodesis * systemic diseases * vision, hearing or vestibular problems * severe trauma or a traffic accident that had an impact on the cervical area.

Keywords: motor imagery action observation pain perception
stepwise parkinson: a smartphone based exercise solution for patients with parkinson's disease

Conditions: Movement Disorders; Parkinson Disease

Summary: the aim of this study is to investigate whether a smartphone app can increase physical activity in patients with parkinson's disease in daily life for a long period of time (12 months).

rationale: exercise affords health benefits for people with parkinson's disease (pd), but implementing exercise in daily life remains challenging. moreover, many training programs are not very scalable. the investigators take an important step forward by developing and studying an innovative and fully decentralized smartphone-based program to increase long-term physical activity in people with pd in daily life. objective: the aim of this study is to investigate whether a smartphone app can increase physical activity in pd patients for a long period of time (12 months). the secondary aim is to test the potential group effect on physical fitness, motor- and non-motor symptoms. thirdly, we aim to investigate whether there is a dose-response relationship between amount of physical activity and physical fitness, motor- and non-motor functioning. study design: double-blind randomized controlled trial. study population: a total of 452 dutch patients with pd who have no other medical conditions that markedly hamper mobility other than pd, no cognitive impairments that make it difficult to use a game on the smartphone and possess a suitable smartphone, will be recruited. intervention: participants will be randomized to a group that will be motivated to increase their physical activity level to a small, medium, large or very large degree with respect to their own baseline level.

Eligibility criteria:
inclusion criteria: * idiopathic pd * hoehn and yahr 1-3 * able to understand the dutch language * able to walk independently * equal to or less than 120 minutes of sports/outdoor activities per day (question 5-28 lasa physical activity questionnaire (lapaq)) * less than 7,000 steps/day during 1-month baseline (week -4 until 0) exclusion criteria: * weekly falls in the previous 3 months * medical conditions that hamper mobility other than pd * living in a nursing home * cognitive impairments that hamper use of the motivational app (subjective evaluation by the assessor) * not in the possession of a suitable smartphone (iphone 5s or newer with ios 10 or higher or android 4.1 or newer)

Keywords: physical activity walking exercise parkinson disease locomotion motivational application
a study in rheumatoid arthritis with an investigational oral p38 map kinase inhibitor vx-702

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to assess the safety and effects of vx-702 in subjects with moderate to severe rheumatoid arthritis and who are taking the drug methotrexate.


Eligibility criteria:
inclusion criteria: * adult patients 18 to 75 years of age with active ra * must have been taking mtx for at least 6 months * no concurrent dmard treatment (other than a stable dose of mtx) exclusion criteria: * planned major surgery (e.g., joint replacement) within the duration of the treatment period of the study * treated with intra-articular injections of corticosteroids within 28 days prior to day 1
adolescent mood during puberty and testosterone

Conditions: Adolescent Depression

Summary: starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention deficit hyperactivity disorder (adhd). this divergence between the sexes during puberty suggests sex-specific pathways of risk and differential effects of sex hormones. the purpose of this research is to determine: 1) sex-specific neural and endocrine features of the pubertal transition that may mediate sex differences in adolescent mood disorders, and 2) the neurophysiological basis of susceptibility to hormone change during puberty.


Eligibility criteria:
inclusion criteria: * between the ages of 11 and 14 * have their own personal mobile device and capability to download the mycap and healthy minds apps * experienced a stressful life event within the last year, or endorse moderate depression (defined by a ces-dc score 16 or higher) exclusion criteria: * previous experience with the healthy minds program * regular meditation practice * current or history of manic episodes, psychotic symptoms, or current suicidal intent * taking any form of exogenous hormones or intrauterine device (iud) within one month of participation in the study * taking medications that directly alter cardiovascular or neurological function

Keywords: puberty depression mood disturbance adolescence stress peripubertal transition hormones eeg sex differences
phrenic nerve injury during pulmonary vein isolation with the second-generation cryoballoon.

Conditions: Phrenic Nerve Palsy

Summary: to determine the most frequent complication associated with cryoballoon pvi. the main hypothesis is to explore the incidence of phrenic nerve palsy.


Eligibility criteria:
inclusion criteria: * age 18 years or older * cryoballoon pvi * periprocedural phrenic lesion exclusion criteria: - non

Keywords: pulmonary vein isolation phrenic nerve palsy paroxysmal atrial fibrillation persistent atrial fibrillation
in-clinic and home-use study of a new blood glucose monitoring system

Conditions: Diabetes

Summary: the purpose of this study is to evaluate the performance and acceptability of a new blood glucose meter.


Eligibility criteria:
inclusion criteria: * type 1 diabetes * age 4 to 24 years * routinely performs blood glucose testing at home, at least 2 times per day, for one month or more before enrollment * has used a handheld game system to play video games within a year of enrollment * if above age 18, subject is able to speak, read, and understand english. if below age 18, subject's parent/guardian is able to speak, read, and understand english, and is able to provide appropriate supervision. * is willing to complete all study procedures, with appropriate parent/guardian supervision exclusion criteria: * hemophilia or any other bleeding disorder * taking prescription anticoagulants (such as warfarin or heparin) or has clotting problems that may prolong bleeding. taking plavix or aspirin daily is not excluded * infection with a blood borne pathogen (e.g., hiv, hepatitis) * subject or parent/guardian is employee of competitive medical device company * cognitive disorder or other condition, which in the opinion of the investigator, would put the person at risk or seriously compromise the integrity of the study
a study of the value of hybrid pet/mr and pet/ct in prostate cancer

Conditions: Prostate Cancer; PET/MR; PET/CT

Summary: according to the latest data from the china national cancer center, prostate cancer has become the most common tumor in the urinary system since 2008. however, conventional imaging techniques including transrectal ultrasound , computed tomography and bone scintigraphy are not sensitive or specific. about 40% of resectable lesions cannot be detected by these techniques. positron emission tomography (pet) provides a valuable tool for the diagnosis and staging of prostate cancer. recently, prostate-specific membrane antigen (psma) as a new novel positron tracer has shown to be effective to detect primary lesions, recurrent and metastatic lesions of prostate cancer. in this prospective study, the investigators will use the most advanced imaging equipments, integrated pet/mr, and pet/ct with prostate cancer-specific imaging agent 68ga-psma and conventional imaging agent \[f-18\]fluorodeoxyglucose to image patients with or suspected of prostate cancer, the aim is to explore the value of hybrid pet/mr and pet/ct in prostate cancer.

according to the latest data from the china national cancer center, prostate cancer has become the most common tumor in the urinary system since 2008. however, conventional imaging techniques including transrectal ultrasound , computed tomography and bone scintigraphy are not sensitive or specific. about 40% of resectable lesions cannot be detected by these techniques. positron emission tomography (pet) provides a valuable tool for the diagnosis and staging of prostate cancer. recently, prostate-specific membrane antigen (psma) as a new novel positron tracer has shown to be effective to detect primary lesions, recurrence and metastatic lesions of prostate cancer. in this prospective study, the investigators will use the most advanced imaging equipment, integrated pet/mr, and pet/ct with prostate cancer-specific imaging agent 68ga-psma and conventional imaging agent \[f-18\]fluorodeoxyglucose to image patients. for patients suspected of or diagnosed with prostate cancer, the investigators aim to evaluate the roles of integrated pet/mr and pet/ct in differential diagnosis, detecting primary and metastatic lesions, guilding biopsy, staging and determining treatment plan prior to treatment; for the patients with a history of prostate cancer, the aim is to evaluate the value of integrated pet/mr and pet/ct for treatment response assessment, detection of recurrences and metastatic lesions.

Eligibility criteria:
inclusion criteria: * patients suspected of or diagnosed with prostate cancer exclusion criteria: * acute systemic diseases and electrolyte disorders * patients with known malignancy in other organs * patients with severe claustrophobia or unstable vital sigh * other serious comorbidities evaluated by primary investigator
impact of labour kinesiotherapy in the quality life of auxiliary nursing in the surgery center

Conditions: Quality of Life; Pain

Summary: the quality of life and daily activities can be affected by muscleskeletal pain and one of the forms of assessment is through the sf-36 questionnaire. the investigators know that the working kinesitherapy is a way to improve the quality of life.

the activities in the work routine can cause pain and negatively affect quality of life. there is the hypothesis that gymnastics may be used for pain and injuries relating to repetitive movement at work. objective the study is assess the impact of labor kinesiotherapy in the quality of life of the operating room nursing assistants.

Eligibility criteria:
inclusion criteria: * professional nursing assistants allocated in the surgical center at least one year * both genders * who agreed to participate in the study by signing the informed consent exclusion criteria: * persons submitted on any surgery in the last six months * with illness or muscle-skeletal disabilities * or who couldn't attend all sessions for vacations or scale

Keywords: public health nursing staff, hospital
change of optic nerve sheath diameter after deflation of pneumatic tourniquet

Conditions: Intracranial Pressure Increase

Summary: the purpose of this study is to evaluate the change of the optic nerve sheath diameter after deflation of pneumatic tourniquet.

deflation of pneumatic tourniquet could induces many changes in various organ systems. it has been shown to affect intracranial pressure. thus, the investigators evaluate the change of optic nerve sheath diameter using ultrasound after deflation of pneumatic tourniquet in patients undergoing knee surgery.

Eligibility criteria:
inclusion criteria: * asa physical status 1-4 * patients undergoing knee surgery using pneumatic tourniquet exclusion criteria: * patients who refuse to participate in this study * patients with history of cerebrovascular disease * patients who are judged ineligible by the medical staff to participate in the study for other reasons
phase 1 dose escalation study of sn2310 injectable emulsion in patients with advanced solid tumors

Conditions: Breast Neoplasms; Colorectal Neoplasms; Pancreatic Neoplasms; Pelvic Neoplasms; Lung Neoplasms

Summary: this is a phase 1 open-label study of sn2310 injectable emulsion in patients with advanced solid malignancies. the study is designed to determine the maximum tolerated dose and dose-limiting toxicity of sn2310 injectable emulsion, and to characterize the pharmacokinetics of sn2310 and sn-38 following intravenous administration of sn2310 injectable emulsion. additionally, evaluation of side effects as a function of dose, and observation of any anti-tumor effects of sn2310 injectable emulsion will be made.

this is a phase 1 open-label study of sn2310 injectable emulsion in patients with advanced solid malignancies who have failed conventional therapy. sn2310 injectable emulsion will be administered intravenously every 21 days. the study is designed to determine the maximum tolerated dose and dose-limiting toxicity of sn2310 injectable emulsion; to characterize the pharmacokinetics of sn2310 and sn-38 following intravenous administration of sn2310 injectable emulsion; to evaluate side effects as a function of dose level; and, to observe any anti-tumor effects of sn2310 injectable emulsion.

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed diagnosis of solid tumor with disease progression despite standard therapy and/or for which no other solid therapeutic option exists * anc \> 1,500 cell/mm3, platelets \> 100,000/mm3 and hgb \> 9 g/dl * at least one unidimensionally measurable lesion per recist * negative serum or urine pregnancy test, if female of childbearing potential exclusion criteria: * female who is pregnant or lactating * history of chronic diarrhea