Kornimate/medical-research-clean huggingface dataset:
quinine and food intake

Conditions: Obesity

Summary: rationale: the appearance of tastants in the small intestine following food ingestion results in the onset of digestion and absorption but can also result in the activation of a negative feedback mechanism from different parts of the intestine to the stomach, the small intestine and to the central nervous system. these processes inhibit food processing, appetite sensations and food intake, and furthermore they increase feelings of satiety and satiation. in this study, we aim to investigate the effects of oral sham feeding and intragastric delivery of a bitter tastant (quinine) on ad libitum food intake, satiation, gastrointestinal symptoms, and heart rate variability. objective: to investigate the effect of oral sham feeding and intragastric delivery of a bitter tastant on food intake. secondary objective(s): 1. to compare the effect of oral sham feeding and intragastric delivery of a bitter tastant on satiation. 2. to assess the effect of oral sham feeding and intragastric delivery of a bitter tastant on gastrointestinal symptoms/complaints. 3. to assess the effect of oral sham feeding and intragastric delivery of a bitter tastant on heart rate variability.


Eligibility criteria:
inclusion criteria: * based on medical history and previous examination, no gastrointestinal complaints and/or gastrointestinal disorders can be defined. * age ≥18 and ≤65 years. this study will include healthy adult subjects (male and female). * bmi ≥18 and ≤25 kg/m2 * body weight stable over at least the last 6 months (≤ 5% weight change allowed) exclusion criteria: * history of severe cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, hematological/immunologic, heent (head, ears, eyes, nose, throat), dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological/psychiatric diseases, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol. the severity of the disease (major interference with the execution of the experiment or potential influence on the study outcomes) will be decided by the principal investigator. * use of medication that can influence study end-points (to be discussed by medical doctor and principal investigator), including vitamin supplementation, within 14 days prior to testing * administration of investigational drugs or participation in any scientific intervention study which may interfere with this study (to be decided by the principle investigator), in the 180 days prior to the study * major abdominal surgery interfering with gastrointestinal function (uncomplicated appendectomy and hysterectomy allowed, and other surgery upon judgement of medical doctor and principle investigator) * dieting (medically prescribed, vegetarian, diabetic, macrobiological, biological dynamic) * unwillingness to eat lasagna bolognese meal * pregnancy, lactation * excessive alcohol consumption (\>20 alcoholic consumptions per week) * smoking * non-tasters of bitter
prospective study to compare the efficacy of e.g.scan to detect barrett's esophagus compared with standard endoscopy

Conditions: Barrett's Esophagus

Summary: the purpose of this study was to evaluate whether a disposable nasal endoscope called "e.g. scan ii" will visualize the esophagus as well as the standard test, sedated endoscopy.

all subjects underwent two procedures: the e.g.scan ii followed by standard endoscopy in a tandem design. the e.g. scan ii is a transnasal endoscope system to capture and transmit images of the esophagus. captured images can be reviewed via the e.g. view for diagnosis of diseases related to the esophagus. generally, the commercial esophagoscope system has reusable probes, but e.g. scan™ ii has a single use probe because reusable probes have the risk of infection and pollution. prior to the e.g.scan, subjects received a standard prep for the procedure. the two procedures were performed by two different experienced endoscopists who were blinded to the indication of the procedure. at both procedures a note was made of any abnormality of the esophagus. every subject with an endoscopic diagnosis of barrett's esophagus had clinical biopsies taken to confirm diagnosis. subject tolerability was measured with a 10-point visual analog scale (vas) where 0 represented the "worst experience" and 10 the "best experience."

Eligibility criteria:
inclusion criteria: 1. adult participants aged 18 years or above who are scheduled for routine upper gi endoscopy for barrett's esophagus surveillance, varices surveillance and dyspepsia. 2. able and willing to give informed consent. exclusion criteria: 1. patients known to be intolerant to endoscopy. 2. patients with frequent epistaxis. 3. patients not clinically fit for endoscopy as judged by their care team. 4. pregnant women. 5. patients with allergy/sensitivity to simethicone (mylicon), phenylephrine, lidocaine nasal spray, benzocaine spray (topex) 6. use of anticoagulants or antiplatelets.

Keywords: barrett's esophagus reflux heartburn screening
echocardiography in cardiac resynchronization therapy (echo-crt)

Conditions: Heart Failure; Cardiac Resynchronization Therapy

Summary: the present observational prospective study aims at identifying echocardiographic parameters (based on the left bundle branch block (lbbb)-like contraction of the left ventricle (lv) ascertained using new methods of echocardiography including speckle tracking strain) that are linked to cardiac resynchronization therapy (crt) response and a better outcome following crt

the cardiac resynchronization therapy (crt) reduces mortality of patients with heart failure and reduced lv ejection fraction. the clinical benefit of crt is mediated by lv reverse remodelling (decrease in lv end-systolic volume over time). however, 30 to 50 % of these patients will not experience lv reverse remodelling following crt. classical parameters of dyssynchrony obtained by conventional methods of echocardiography (including doppler tissue imaging) have a limited value in predicting crt response. meanwhile, patients with a left bundle branch block (lbbb) on the electrocardiogram experience more frequently lv reverse remodelling than those without a lbbb. lbbb is responsible for specific lv contractile abnormalities that can be identified by speckle tracking strain echocardiography (early septal contraction, stretching of late contraction of the postero-lateral wall). the predictive value of these abnormalities remains to be studied. thus, it has been hypothesised that these lbbb-related contractile abnormalities may be independent predictors of lv reverse remodelling and outcome following crt. the present observational prospective study aims at identifying echocardiographic parameters (based on the lbbb-like contraction of the lv ascertained using new methods of echocardiography including speckle tracking strain) that are linked to crt response and a better outcome following crt.

Eligibility criteria:
inclusion criteria: * heart failure with left ventricular ejection fraction less than 35 % * qrs duration over than 120 ms * clinical indication for crt exclusion criteria: * rythmologic indication of crt for atrial fibrillation control * rythmologic indication of crt for left ventricular ejection fraction between 35% and 45%

Keywords: cardiac resynchronization therapy echocardiography biventricular pacing
plyometric exercises versus wii training in children with unilateral cerebral palsy

Conditions: Sports Physical Therapy

Summary: plyometric training includes muscle contraction that moves rapidly from the eccentric to the concentric phase of movement while using proper biomechanics. it is an effective neuromuscular stimulus that can improve motor functions of children with cerebral palsy. in plyometric training, muscles exert maximum force in short intervals of time, with the goal of increasing power. commercially available video games have been used for a wide range of clinical populations with generally positive clinical outcomes. they have been shown to be active enough to provide an increase in energy expenditure and physical activity in children with cerebral palsy. furthermore, an early case study showed improvements in visual-perceptual processing, balance, and mobility in a child with cerebral palsy.


Eligibility criteria:
inclusion criteria: * aged 8-12 years; * able to understand and follow simple commands. exclusion criteria: - severe uncontrolled seizures;

Keywords: cerebral palsy unilateral cerebral palsy hand grip strength upper extremity function range of motion wii training plyometric exercises
a study to compare laparoscopic to echographic assisted transversus abdominis plane block in laparoscopic colectomy

Conditions: Laparoscopic Colectomy; Pain, Postoperative

Summary: the purpose of this study is to compare the postoperative pain, the time needed and other clinical outcomes in patients who, during laparoscopic colectomy, will be injected with a local anesthetic (ropivacaine) through an ultrasound guided technique performed by the anaesthesiologist or throught a laparoscopic assisted technique performed by the surgeon


Eligibility criteria:
inclusion criteria: * patients candidates to laparoscopic colorectal surgery * signed informed consent exclusion criteria: * age \< 18 years old * pregnancy * allergy to local anaesthetics * spinal or epidural analgesia * acute inflammatory abdominal pathologies * chronic pain syndrome * contraindications to nonsteroidal anti-inflammatory drugs (nsaids)

Keywords: transversus abdominis plane (tap) block local anesthetic infiltrations
umbilical cord derived mesenchymal stem cells therapy in hypoxic ischemic encephalopathy

Conditions: Hypoxic Ischemic Encephalopathy

Summary: this study is to evaluate the safety and efficacy of umbilical cord derived mesenchymal stem cells transplantation in hypoxic ischemic encephalopathy.

to date,hypoxic ischemic encephalopathy is refractory, including after carbon monoxide poisoning, cardiopulmonary resuscitation,hemorrhagic shock and cerebral infarction etc. we used mesenchymal stem cells via portal vein infusion method to treat hypoxic ischemic encephalopathy. with different durations of follow-up, we cleared therapeutic effect, the quality of life and prognostic implications of the cord blood stem cell infusion on hypoxic ischemic encephalopathy, and evaluated the adverse reactions, through the neurological function score (nihss，barthel index), cognitive score (moca, mmse),and the international uniform parkinson rating scale score (updrs). here, we seek new means for the treatment of hypoxic ischemic encephalopathy, and provide the basis for clinical for further application of umbilical cord blood derived mesenchymal stem cells. on the basis of conventional therapy, at the same time, selected patients were given by intravenous infusion of umbilical cord blood stem cells 100-800 million. all patients before treatment, after treatment for 15days, 90days and 180 days were evaluated respectively the curative effect. the neurological function score (nihss score, barthel index) was observed in patients with the ability to live independently and prognosis; moca, mmse were used in the evaluation of cognitive function ；updrs was used in the evaluation of extrapyramidal tract function.

Eligibility criteria:
inclusion criteria: patients are screened foe enrollment in the study if both clinal signs and laboratory tests meet the diagnosis standards recommended by international classification of diseases-10 about hypoxic ischemic encephalopathy. exclusion criteria: exclusion criteria are any clinically significant diseases in liver,kidney,and heart. additional exclusion criteria are no pregnancy,no immunosuppressive medication, no tumor, no viral diseases or diseases associated with immunodeficiency.
livionex on reducing plaque accumulation and improving oral health in children

Conditions: Plaque, Dental; Caries, Dental; Oral Hygiene

Summary: this is an investigator initiated randomized double-blind pilot study at the ucsf pediatric dental clinics to compare effectiveness of a new toothpaste livionex dental gel with a standard children's toothpaste containing 1500 ppm fluoride in reducing dental plaque and caries in healthy and well children every 3 months for up to 12 months.

dental plaque is the primary etiological factor in the initiation of caries, gingival inflammation and subsequent destruction of periodontal tissues. effective oral hygiene eliminates microbial plaque leading to resolution of gingival inflammation. livionex dental gel is a toothpaste that is effective in reducing plaque in adults while not containing the additives found in other toothpastes that can cause increased gingival irritation. the investigators hypothesize that brushing with livionex toothpaste creates an oral environment that prevents dental plaque accumulation and promotes oral health in children. this study will prospectively enroll 78 children aged 9 months to 12 years from ucsf pediatric dental clinics. upon obtaining an informed consent, children will be randomized in a 1:1 ratio to the use of test (livionex dental gel) and control toothpaste (a standard children's toothpaste containing 1500 ppm fluoride ). all patients will be provided a soft brush at enrollment, and the child and/or the parent will be taught to brush/clean after the first exam, with the assigned dentifrice, at the study center before they go home. additionally, each subject will receive a new brush at every 3-month visit. subjects will undergo a dental exam by a trained dentist including caries assessment (at baseline, 1, 3, 6, 9 or 12 months), dental plaque photograph, (at baseline, 1, 3, 6 and 9 or 12 months), and swab samples for dental plaque and saliva will be collected at all study visits. a questionnaire will be given to address dentifrice and brushing experience in a phone call one month after enrollment and at the last study visit. data on compliance and side effects of toothpastes will be collected at each of the calls.

Eligibility criteria:
inclusion criteria: * healthy children aged 9 months to 12 years. * parent and children are able complete the study procedures. * parent/legal guardian willing to allow their child participate and sign informed consent form. exclusion criteria: * parents are unable to understand or participate in study procedures. * known allergy to edathamil or known allergy to multiple hygiene and cosmetic products.

Keywords: livionex dental gel, toothpaste
effect of intermittent fasting to metabolic and oxidative stress marker

Conditions: Obesity

Summary: the world prevalence of obesity in adult population in 2016 was 650 million while in indonesia, it has increased from 14,8 percent to 21,8 percent in 2018. obesity is an established risk factors for metabolic and non communicable- diseases. the purpose of this research was to assess the different effect on waist circumference, insulin resistance and oxidative stress marker between fasting (intervention) group and not fasting (control) group after 8 weeks 5:2 intermittent fasting (if) among obese male workers.

intermittent fasting is eating pattern in that cycles between periods of fasting and eating. 5:2 intermittent fasting (if) is a form of time-restricted fasting which no calories are consumed for at least 14 hours (for 4 am to 6 pm) will done in two non-consecutive days days per week, followed by ad libitum intake on the remaining days, with water restriction too. participants will be distributed to each group by simple randomization. this study will access the characteristic data, dietary intake and physical activity from the participants. anthropometry and blood sample (for insulin resistance (homa-ir) and oxidative stress (malondialdehyde and catalase)) were taken at baseline and at the end of the study. participants from each group will gets counseling at the second week of intervention and they will follow up to 8 weeks with control and evaluation form.

Eligibility criteria:
inclusion criteria: * men aged 30-59 years * has a bmi ≥ 25 kg/m\^2 * has a waist circumference of ≥ 90 cm * willingness to participate in the whole study by signing informed consent exclusion criteria: * doing regular fasting (2 days a week) for 12 weeks before the study begins. * in a certain diet at the moment * participants who are taking drugs that can affect blood sugar, insulin, and drugs (steroids, beta blockers, adrenergics), vitamins or herbal supplements and other drugs that affect oxidative stress. * participants suffering from obesity with complications such as impaired liver function, impaired kidney function, heart disease and type 2 diabetes mellitus are known through anamnesis and physical examination as well as fasting blood sugar checks. * participants that has a fever with temperatures\> 37.5 ℃

Keywords: obesity intermittent fasting insulin resistance stress oxidative marker waist circumference
radial extracorporeal shock wave therapy and visual feedback balance training on lower limb post-stroke spasticity, trunk performance and balance:

Conditions: Stroke, Ischemic; Stroke Hemorrhagic; Spasticity as Sequela of Stroke; Spastic Gait; Balance; Distorted

Summary: this study assess the relationship between lower limb spasticity and trunk movements during static and dynamic balance in post-stroke patients who also underwent conventional physical therapy, visual feedback balance training and radial extracorporeal shock wave therapy intervention.

the stabilometric assessment through prokin system complemented the clinical evaluation and provided a more objective, global insight into the combined therapeutic effect. the stabilometric computerized system is both an assessment tool and a training system for static, dynamic balance and trunk. to date, it was used in various clinical trials as a training tool for promoting stance and balance improvement in several neurorehabilitation programs. additional outcomes focused on the effectiveness on pain intensity, clonus, passive range of motion, lower limb sensorimotor function, and functionality. the adverse events were also attentively monitored during the trial.

Eligibility criteria:
inclusion criteria: * a hemorrhagic or ischemic stroke in acute, subacute or chronic phase; * no history of previous stroke; * lower limb post-stroke spasticity and spasticity grade ≥1 on the modified ashworth scale (mas); * pain intensity measured on visual analogue scale (vas) ≥1; * ability to stand unassisted in upright position for 30 seconds; * no change in anti-spastic drug dose or treatment and no changes in analgesic medication, as it could affect the results on the modified ashworth scale and the visual analogue scale * adult patients (\>18 years old) exclusion criteria: * other neurological and orthopaedic disorders or lower limb deformities that could in-terfere with motor performance and balance; * myopathies; * severe cognitive impairment, severe aphasia or inability to understand instructions; * severe spasticity; * visual field conditions or hemineglect; * patients unable to undergo follow-up evaluation and excluded from the final analysis; * anticoagulant medication or any contraindication to receive radial extracorporeal shockwave therapy (reswt), or any contraindication to physical therapy.

Keywords: stroke spasticity balance trainer balance impairment neurologic rehabilitation
transcutaneous electrical acupoint stimulation (teas) on prevention hypotension in elderly

Conditions: Hypotension

Summary: despite prophylactic measures, hypotension remains a common side-effect of spinal anesthesia. electroacupuncture influences hemodynamics. we hypothesized that transcutaneous electrical acupuncture point stimulation (teas) at traditionally used acupuncture points would reduce the severity of hypotension after spinal anesthesia in geriatric patients undergoing hernia surgery.

after obtaining written informed patient consent, 60 geriatric patients undergoing hernia surgery under spinal anesthesia were randomized into two groups. in the placebo teas group, the gel electrodes will be applied at the same anatomical points without stimulation. the acupoint group will receive teas at the pc-5, pc-6, and st-36 points bilaterally before the spinal anesthesia. the spinal anesthesia will be performed using 12.5 mg 0.5% bupivacaine was from the l3-4 or l4-5 interval with a 25g quincke spinal needle. hemodynamic data will be followed every five minutes.

Eligibility criteria:
inclusion criteria: * asa i-iii patients aged 65 years and older who are scheduled for inguinal hernia repair exclusion criteria: * patients with neurological or psychological diseases * patients who have been treated with teas or acupuncture before, * patients with heart failure and pace-maker * those who have a local infection in the teas area.
thyroid function among pediatric patients with dm

Conditions: Thyroid Function in DM

Summary: thyroid function among pediatric patients with type1 diabetes mellitus at the first presentation, from patients' characteristics to disease severity

type-i diabetes mellitus is an auto immune disease. it is the most common type of diabetes in children and adolescents. it is also the most common chronic disease in children in the developed countries. the illness is characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. globally, it is estimated that there are almost 500,000 children aged under 15 years with type 1diabetes, with large geographical variations in incidence. * furthermore between 10 to 70% of these children present in diabetic ketoacidosis (dka) as their first presentation of the disease. * in addition it can be associated with other auto immune disorders that may influence the control of diabetes by disruption of the function of respective organs and enhance the opportunity of developing dka as the first manifestation of their disease. * in particular, autoimmune thyroiditis (ait) is the most common disorder associated with type 1 diabetes mellitus. * ait and type 1 diabetes mellitus have a common genetic background and similar pathogenesis; hence, they could occur in the same individual or family. the prevalence of thyroid autoantibodies in children with type1 diabetes mellitus ranges from 3% to 50% in different countries and populations, which is markedly higher than in the general population (range, 1% to 4%). * besides thyroid autoantibodies can be detected at the initial diagnosis and after it. * thyroiditis is often clinically silent but it may progress to autoimmune thyroid disease (aitd), recognized as overt or subclinical hypothyroidism or hyperthyroidism. * the american diabetes association (ada) recommended screening thyroid-stimulating hormone after diagnosis of diabetes and then after every one to two years. it also recommended that patients found to have positive anti-thyroid peroxidase antibodies with normal thyroid function tests should be screened more frequently, every six months to a year .

Eligibility criteria:
inclusion criteria: * - patients between 2 year and \<18 years of age in both sex * patients with t1dm that had not been on any thyroid medication exclusion criteria: * - patients \ 18 years of age in both sex * patient with systemic illnesses, diagnosed thyroid disorders and patients taking medications