Kornimate/medical-research-clean huggingface dataset:
capox and pd-1 antibody combined with or without radiotherapy for mss locally advanced rectal cancer

Conditions: Locally Advanced Rectal Cancer; Neoadjuvant Therapy

Summary: torch-itnt is a prospective, multicentre, randomized phase ii trial. 198 larc (t3-4/n+m0, distance from anal verge ≤12cm) patients will be treated with total neoadjuvant therapy (tnt) and assigned to group a and group b (1:1). group a receives 6 cycles of toripalimab combined with capox (toricapox). group b receives scrt (25gy/5fx) followed by 6 cycles of toricapox. tme surgery is scheduled after tnt while a watch and wait (w\&w) option can be applied to patients achieving clinical complete response (ccr). the primary endpoint is complete response (cr, pathological complete response \[pcr\] plus ccr) rate. the secondary endpoints include the grade 3-4 acute adverse effects (ae) rate, anal preservation rate, 3-year dfs rate, etc.


Eligibility criteria:
inclusion criteria: 1. pathological confirmed adenocarcinoma; 2. clinical stage t3-4 and/or n+; 3. the distance from anal verge ≤ 12 cm; 4. without distance metastases; 5. age 18-70 years old, female and male; 6. kps ≥ 70; 7. baseline blood and biochemical indicators meet the following criteria: neutrophils ≥ 1.5 × 10\^9/l, hb ≥ 90 g/l, plt ≥ 100 × 10\^9/l, alt/ ast ≤ 2.5 uln, cr ≤ 1 uln; 8. with good compliance and signed the consent form. exclusion criteria: 1. pregnancy or breast-feeding women; 2. known history of other malignancies within 5 years; 3. known history of previous anti-tumor treatment, including radiotherapy, chemotherapy, immune checkpoint inhibitors, t cell-related therapy, etc; 4. known history of severe neurological or mental illness (such as schizophrenia, dementia or epilepsy); 5. current severe cardiac disease (cardiac dysfunction and arrhythmia), renal dysfunction and liver dysfunction; 6. acute cardiac infarction or cerebral ischemic stroke occurred within 6 months before recruitment; 7. uncontrolled infection which needs systemic therapy; 8. active autoimmune disease or immunodeficiencies, known history of organ transplantation or systematic use of immunosuppressive agents; 9. known history of human immunodeficiency virus (hiv) infection (i.e., hiv 1 to 2 antibody positive), active syphilis infection, active pulmonary tuberculosis infection 10. allergic to any component of the therapy.
whey protein pre-load and postprandial glycemia in pregnancy

Conditions: Pregnancy; Postprandial Glycemia

Summary: this pilot study aims to investigate the intake of whey protein prior to carbohydrate intake as an approach to modulate postprandial glucose excursions during pregnancy.

gestational diabetes (gdm) has transgenerational health consequences and increases the risk of type 2 diabetes mellitus in both mother and child. however, there is a lack of practical nutritional concepts for the prevention and treatment of gdm. this randomized controlled pilot study investigates whether the intake of a protein drink before carbohydrate intake lowers postprandial blood glucose levels of pregnant women. therefore, two 75g oral glucose tolerance tests are performed in 20 pregnant women in a cross-over design, whereby a whey protein solution is drunk 30 minutes before one of the oral glucose tolerance tests (ogtt). if a clinically relevant effect on blood glucose levels is identified, this project can clarify whether the reduction in postprandial glycemia was caused by changes in the secretion of insulin and incretins.

Eligibility criteria:
inclusion criteria: * pregnant women between 24+0 and 27+6 (+/- 7 days) weeks of pregnancy after menstruation * bmi before pregnancy: 18 - 29.9 kg/m2 * no known underlying diseases * understanding and voluntary signing of a consent form before study-related examinations exclusion criteria: * age \< 18 years * diabetes mellitus type 1 or type 2 * drug therapy that raises or lowers blood sugar, e.g. steroids, antidiabetics, insulin. * endocrine disorders (e.g. hyperthyroidism, polycystic ovary syndrome (pcos), ...) * current depression or other mental illnesses * eating disorder * regular intake of medication other than vitamins/trace elements during pregnancy * estimated glomerular filtration rate (egfr) \< 60 ml/min/1.73 m² * c-reactive protein \> 10 mg/l * transaminase elevation of 2 times the upper norm * pre-existing cardiac diseases * drug and/or alcohol abuse * hb \< 12 g/dl * no consent to be informed about incidentally discovered pathological findings * any other (clinical) condition that would endanger participants safety or question scientific success according to the physicians opinion.

Keywords: postprandial glucose excursions glycemia whey protein protein pre-load pregnancy gestational diabetes mellitus insulin secretion incretins
subcutaneous electrical stimulation in the prevention of postoperative ileus

Conditions: Ileus

Summary: assess whether the application of electrical stimulation in patients undergoing subcutaneous colon cancer in a multimodal rehabilitation program (fast track) decreases the incidence of postoperative ileus, improving the results of morbidity and mortality, hospitalization and health care costs.

prospective randomized study on the application of subcutaneous abdominal electrical stimulation in the postoperative of colonic surgery and its relationship with the appearance of postoperative ileus.

Eligibility criteria:
inclusion criteria: * patients undergoing colorectal surgery. * signing informed consent. exclusion criteria: * patients with no oral nutrition (dysphagia, esophageal stricture, pyloric stenosis) * patients with contraindications for electrical stimulation. * psychiatric disorders * hiv * pregnant or breastfeeding * intestinal obstruction * uncontrolled infection * asa iv * no acceptance or failure to follow protocol multimodal rehabilitation.
amylase and hypersomnia

Conditions: Hypersomnia in Children

Summary: hypersomnia is defined as a reduced ability to remain awake during the day. there are basically two types of central hypersomnia: narcolepsy and idiopathic hypersomnia. currently, the diagnosis of these sleep disorders is based on polysomnographic recordings which is difficult to access. tests of sleepiness (epworth, karolinska) are subjective. a biological marker of sleepiness, easily accessible and measurable, would be very useful for the diagnosis and therapeutic follow up of excessive diurnal sleepiness. salivary secretions appear as good physiological markers. studies have shown for healthy subjects, that the expression and activity of salivary amylase are increased when subjects are deprived of sleep. the investigators propose to explore the usefulness of salivary biomarkers (including amylase) as a new non-invasive and simple technique for the assessment of excessive daytime sleepiness.


Eligibility criteria:
inclusion criteria: subjects with hypersomnia (narcolepsy or idiopathic): * children and adolescents with hypersomnia (according to icsd diagnostic criteria 2); narcolepsy or idiopathic hypersomnia (with or without lengthening of sleep), * aged \> 6 years and \<18 years, * no treatment, * parent consent control subjects: * healthy children and adolescents without any known pathology, * aged \> 6 years and \<18 years, * matched on sex and age\> 6 years - \ 12 - \<18 years) * parent consent exclusion criteria: * subjects with hypersomnia (narcolepsy or idiopathic): * secondary narcolepsy, * symptomatic hypersomnia, * restless legs syndrome, * sleep apnea syndrome, * severe neurological, psychiatric, cognitive or endocrinological concomitant disease. control subjects: * hypersomnia, * restless legs syndrome, * sleep apnea syndrome, * severe neurological, psychiatric, cognitive or endocrinological concomitant disease, * sleep disorder evaluated by a score \> 70 on the sleep disturbance scale for children19, * excessive daytime sleepiness according to epworth scales (score \> 10), * abnormal sleep time according to the age (sleep diary).

Keywords: hypersomnia narcolepsy amylase salivary sampling
electronic pediatric emergency ruler vs the broselow tape.

Conditions: Time Until Identification of Defined Parameter

Summary: comparison of two different pediatric emergency rulers for length-based body weight estimation in pediatric emergencies. primary outcome is the time needed to identify four defined parameters from the pediatric emergency rulers during a low-fidelity pediatric emergency scenario (cardiac arrest). secondary outcome is the correctness of the identified parameters and the percentage deviation from the correct value.

medical team members (paramedics, emt) of schutz und rettung zurich, zurich switzerland were asked to participate in this study. if they were not familiar with one of the three devices written informed consent was obtained and the participant included in this study. this exclusion criteria was necessary to prevent a bias by already knowing where to find the information of interest. the pediatric emergency rulers investigated were the electronic pediatric emergency ruler (eper) and the broselow tape (bt) all participants were instructed for the use of the two pediatric emergency rulers and were given time to practice with each device using one training manikin (sim-baby) after they felt comfortable using the devices the participants were randomly assigned to use each device only once with one of two different manikins: resusci baby, laerdal/dräger medical switzerland ag, liebefeld, switzerland ambu® junior, ambu® gmbh, bad nauheim, germany each manikin was only used once for the same participant. this guaranteed that the participants were blinded for the manikins. the low-fidelity pediatric emergency scenario simulated was a cardiac arrest and the participants were asked to identify the following information from the pediatric emergency rulers: estimated body weight joule suggested for defibrillation recommended epinephrine dose suggested endotracheal tube size participants stood aside from the manikin with a pediatric emergency ruler in their hand. after they stated they were ready, the facilitator started a countdown from three and gave the command to start. this setting was identical for all two pediatric emergency rulers and all two manikins. the time until each parameter was identified and the value of the parameter were recorded. primary outcome was the time needed to identify the four above defined parameters. secondary outcome was the correctness of the identified parameters and the percentage deviation from the correct value.

Eligibility criteria:
inclusion criteria: * medical team members (paramedics, emt) of schutz und rettung zurich, zurich, switzerland * written informed consent exclusion criteria: * having worked with one of the pediatric emergency rulers and knowing where to find the defined parameters

Keywords: weight estimation patient safety
prevalence and associated factors of functional gastrointestinal disorders among children

Conditions: Functional Gastrointestinal Disorders

Summary: the definition of functional gastrointestinal disorders (fgids) has changed over time from the absence of organic disease to a stress-related or psychiatric disorder to a motility disorder, and with rome iii, to a disorder of gi functioning, then rome iv in 2016 defined fgids as : disorders of gut-brain interaction. it is a group of disorders classified by gi symptoms related to any combination of the following: motility disturbance, visceral hypersensitivity,altered mucosal and immune function, altered gut microbiota, and altered central nervous system (cns) processing. fgids are observed in infants and young children worldwide with variable frequency related studies done in variable places around the worled show the following results : the prevalence of fgids in chinese infants and young children is 27.3%.and 40 % in south american infants and 30 % of african infants and 35.1 % of infants presented to tertiary care hospital in istunbul.turkey.

the etiology of these disorders remains uncertain and thought to be due to subtle alteration of the normal development or maladaptive behavioral response to a variety of internal or external stimuli .as a group of disorders; fgids in young children are a major challenge to the already overstretched pediatric gastroenterology services across the world .infants and young children with fgids visit medical professionals more frequently and experience poor quality of life . in addition, fgids in infancy are linked with detrimental repercussions such as maternal depression, poor infant and mother bonding,and poor physical growth .

Eligibility criteria:
inclusion criteria: * age group 1 to 18 years old exclusion criteria: * age group bwlow 1 year and above 18 years having other git problem as : * git bleeding * h pylori infection * cow's milk protein allergy or ibd or any other symptoms suggestive to organic gi disease
a cross-sectional investigational study to evaluate the sensitivity, specificity, and utility of the medmira inc. multiplo® complete syphilis (tp/ntp) antibody test (poct) to diagnose infectious syphilis in participants attending the sexual health clinic in ottawa, ontario.

Conditions: Syphilis

Summary: due to the recent resurgence of infectious syphilis in canada and the changing epidemiology of the disease to involve heterosexuals and females of child bearing age leading to a record number of congenital syphilis cases and stillbirths, the demand of a rapid test such as poct that can be used at the place and time that front-line public health workers meet the at risk population is getting louder. indeed during a number of federal, provincial and territorial meetings on the control of syphilis outbreaks in canada, requests for poct to detect syphilis infections have repeatedly come up. however, before a poct can be widely used, research to find out if it is accurate and reliable is necessary. this study is designed to test the performance of the medmira inc. multiplo® complete syphilis (tp/ntp) antibody test (poct) (medmira inc., halifax, nova scotia) in an urban clinic (sexual health clinic) in ottawa, ontario, canada and compare its performance in parallel with the usual testing method (the gold standard, i.e. conventional syphilis serology testing).


Eligibility criteria:
inclusion criteria: * individuals attending the clinic for routine sexual health care and requiring syphilis testing as part of this care, who are able to provide informed consent and are a minimum 16 years of age are eligible for this study. this includes patients attending the clinic for follow-up appointments following diagnosis with syphilis infection. those who have had other stis in the past, or being suspected of having other stis, are not excluded as long as testing for syphilis is part of the care provided to them. once it has been determined that the exclusion criteria does not apply to a patient, the recruitment of participants will be offered without other pre-selection criteria unless there may be other unforeseeable circumstances arising, such as shortage of clinic staff or large numbers of patients in attendance. exclusion criteria: * those who, at the discretion of the hcps/research co-ordinator, appear intoxicated and/or with extreme distress, or confused, will be excluded from this research because they would not be able to provide informed consent to participate, as well as those below the age of 16 years.

Keywords: syphilis tp/ntp multiplo complete syphilis (tp/ntp) antibody test medmira treponema pallidum
comparing asthma action plans for pediatric asthma

Conditions: Asthma

Summary: the purpose of this study is to evaluate and compare the relative effectiveness of two asthma action plans (pictorial versus written) in terms of asthma action plan knowledge, medication use, and family satisfaction with asthma education.

asthma medical regimens are complex for families, requiring changes in the types and amounts of medication based on the frequency and intensity of symptoms. written asthma action plans (aap's) are commonly used to provide a set of instructions to help parents and children implement these complicated regimens. however, written aap's require substantial literacy levels, so for younger children, low-literacy families, or non-english speaking families, a pictorial version of the aap may be more understandable and useful. the study aims to validate a newly developed, fully pictorial aap in terms of its relative impact on parent- and child-reported knowledge of the action plan, medication use, and parent- and child-reported satisfaction, when compared to a standard-care written aap.

Eligibility criteria:
inclusion criteria: * children who are new patients * receive a diagnosis of persistent asthma * are in need of an asthma action plan exclusion criteria: * diagnosed with intermittent asthma * an established patient who already has an asthma action plan * not english or spanish speaking

Keywords: pediatric asthma asthma action plans patient education medication adherence
effect of single-dose dexmedetomidine on airway reflex in adult with oral intubation after thyroidectomy

Conditions: Coughing

Summary: coughing during emergence from general anaesthesia may lead to dangerous effects including laryngospasm, detrimental haemodynamic changes. post-thyroidectomy bleeding occurs in 1-4% of patients, and severe coughing may cause bleeding. dexmedetomidine, a potent α adrenoreceptor agonist, is theoretically appropriate for reducing airway and haemodynamic reflexes during emergence from anaesthesia. in this study, we investigated whether intravenous single-dose dexmedetomidine at the end of surgery reduces coughing during extubation after thyroidectomy.


Eligibility criteria:
inclusion criteria: * asa physical status 1 or 2 patients patients scheduled for thyroidectomy exclusion criteria: * severe cardiovascular disease history of motion sickness active status of upper respiratory infection allergy to dexmedetomidine patients who cannot understand korean
comparation of different devices to measure corneal thickness

Conditions: Corneal Thickness

Summary: comparison of different methods for measuring peoples corneal thickness

volunteers with healthy corneas will be measured by different instruments to detect their corneal thickness. first interindividual difference between the instruments will be reviewed. people will be measured again two times on two different days to examine an interindividual difference in all instruments.

Eligibility criteria:
inclusion criteria: * healthy cornea exclusion criteria: * myopia or astigmatism over 1,5 dpt * corneal surgery * acute ocular inflammation * lost of vision

Keywords: cornea sl oct spectral oct cornea modul ultrasound pachymetry pentacam
effect of virtual reality on upper extremity function post-operative rotator cuff repair

Conditions: Rotator Cuff Impingement Syndrome; Rotator Cuff Tears; Rotator Cuff Injuries

Summary: the aim of the study is to investigate the effect and the impact of performing virtual reality intervention on upper extremity function in patients with post-operative rotator cuff repair. the main question that it aims to answer is: does the application of virtual reality intervention improves upper extremity function in patients with post-operative rotator cuff repair. participants will be randomized into 2 groups: the control group receiving conventional physical therapy intervention and the experimental group receiving the virtual reality intervention.

rotator cuff tears are one of the most common disorders of the shoulder that result in shoulder pain and dysfunction. it affects about 30% of individuals that are older than 60 years. the conservative management is the first-line treatment for a rotator cuff tear, but a surgical rotator cuff repair (rcr) is required if the conservative management failed. post-operative rehabilitation requires up to 12 weeks. but, virtual reality (vr) intervention is emerging as a viable alternative for musculoskeletal rehabilitation of the upper limb. unlike in neuro-rehabilitation, vr is still poorly used in orthopedic rehabilitation. thus, the investigators hypothesize that performing virtual reality intervention will improve the upper extremity function in patients with post-operative rotator cuff repair.

Eligibility criteria:
inclusion criteria: 1. older than 18 years old and younger than 70 years old, and referred by the adult orthopedic department with arthroscopic rc repair of a non-retracted isolated full-thickness supraspinatus tear with maximum 5 days post operation. 2. poor response to initial non-operative treatment. exclusion criteria: 1. large-sized rc tears (3-5 cm), 2. massive or irreparable rc tears, 3. anteroinferior labral (bankart) or superior labrum anterior to posterior lesions, 4. severe glenohumeral osteoarthritis, 5. adhesive capsulitis, or 6. previous surgery on the affected shoulder 7. re-tears of the rc. 8. indication for revision rcr 9. severe neurological deficits 10. infection in the affected shoulder 11. blindness and/or illiteracy

Keywords: rotator cuff repair post-operative upper extremity function
construction of a prognostic and prediction model for perioperative immunotherapy in nsclc: a multi - omics perspective

Conditions: NSCLC Stage IIIA/B; NSCLC Stage II

Summary: this research focuses on exploring biomarkers for the application of pd - 1/pd - l1 immune checkpoint inhibitors in the perioperative immunotherapy of lung cancer. multi - index tests are conducted on tissues prior to treatment, as well as blood samples at baseline and during the treatment course. the goal is to identify biomarkers capable of predicting the efficacy of neoadjuvant and adjuvant immunotherapies. additionally, by integrating these multiple - index data into models, patients are to be stratified based on their potential benefits from perioperative immunotherapy, providing personalized guidance for clinical decision - making.


Eligibility criteria:
inclusion criteria: * nsclc, clinical tumor stage ii-iiib * without egfr/alk gene mutation * patient 18 years or older. * scheduled for neoadjuvant immunotherapy. * eastern cooperative oncology group (ecog) performance status score 0-1 * life expectancy ≥ 12 weeks. * patient able to understand and sign written informed consent. exclusion criteria: * with other cancers (excluding nsclc or skin cancer other than melanoma, or cancers treated curatively with follow up of more than 5 years without recurrence). * with history of chemotherapy or radiotherapy (including pre - operative and post - operative adjuvant chemotherapy and radiotherapy) or systemic anti - tumor treatment. * with autoimmune diseases unsuitable for pd - 1 monoclonal antibody treatment, including but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid syndrome, wegener's granulomatosis, sjogren's syndrome, guillain - barré syndrome, or multiple sclerosis. * patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits) and/or otherwise considered by the investigator to be unlikely to complete the study.

Keywords: multi - omics biomarkers immunotherapy perioperative ctdna mrd