Kornimate/medical-research-clean huggingface dataset:
promoting aerobic training in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: multiple sclerosis (ms) is a chronic neurological disease characterized by inflammation and degeneration within the central nervous system. over the course of the disease, most patients with ms successively accumulate inflammatory lesions and axonal damage with an increasing degree of disability. thus, pharmacological treatment options are currently adopted to limit inflammation and to decrease the relapse rate, or simply to alleviate symptoms. on the other hand, neurorehabilitation aims to maintain and possibly improve the residual capacities of neurological patients in order to preserve personal and social activities, constituting an important part of quality health care for ms patients. however, to date, there is no definite agreement on which specific exercise therapy program can be considered the most successful in improving activities and participation. several studies suggest that a training based on voluntary movements produces greater improvements than a passive treatment. aerobic exercise training has been also shown to have significant neurophysiological effects in different populations. furtherly, sports activity may increase adherence and motivation, especially in a young population such as the ms community. however, feasibility of sports activity has not been investigated yet and, in general, the potential interest of these approaches for ms patients remains to determine. this study aims at promoting physical activity in people with ms. specific objectives are: (i) to evaluate the motor behavioral and neural changes induced by aerobic exercise combined with upper limb motor training based on task-oriented exercises; (ii) to assess the feasibility of leisure time physical activity (e.g. water sports activities) largely involving upper limb function. participants will receive task-oriented treatment, but only the experimental group will perform also aerobic training in order to evaluate the effect of aerobic exercise. moreover, the role of sports activities will be preliminary investigated, by promoting the participation of the included patients to local or national events focusing on adapted aerobic sports specifically involving upper limb function (e.g., water sports such as sailing, windsurfing, canoeing). clinical measures will be performed before and after interventions.


Eligibility criteria:
inclusion criteria: * multiple sclerosis diagnosis according to mcdonald criteria * relapsing-remitting course * absence of relapses in the last three months * an expanded disability status score (edss) ≤ 4 exclusion criteria: * steroid-use, psychiatric disorders or severe cognitive impairment * acute cardio-respiratory diseases * magnetic resonance imaging contraindications

Keywords: aerobic exercise sports activity motor performance neural plasticity participation upper limb
reproducibility of a new practical newborn behavioral observation scale

Conditions: Premature Newborn

Summary: neonatal intensive care is necessary for the survival of preterm baby. several studies show the deleterious effect on the immature brain due to stimulations caused by the environment and hospital care. however, a specific and individualized support to the development during the first weeks of this preterm patient has a positive effect on newborn development. a new practical newborn behavioral observation scale has been developed by the investigators care unit in order to adapt care and individualized support to the development for each patient. the goal of this study is to estimate the external reproductibility of this scale by experimented nurse in order to implement an individualized care program.


Eligibility criteria:
inclusion criteria: * term of birth between 24 and 33 weeks of amenorrhea * weight less than 1500g birth; * postnatal age between 1 and 60 days * consent form of parent in order to film their baby exclusion criteria:

Keywords: nursing care observational scale neonate premature infant developmental care
effectiveness of specialised cognitive behavioural therapy (cbt) for tinnitus.

Conditions: Tinnitus, Subjective

Summary: this is an observational study of specialised cbt for tinnitus for adults delivered in routine care.


Eligibility criteria:
inclusion criteria: * tinnitus is the primary complaint and reason for seeking help * participant is at least 17 years of age, exclusion criteria: * unable to read and write in dutch * tinnitus is not the primary complaint * person is under 17 years of age * participant has a health condition that prevents them from attending treatment centre * an ear nose throat (ent) physician assesses the participant as having ontological condition that requires medical treatment

Keywords: tinnitus cbt cognitive behaviour therapy
effect of cemented stem design on periprosthetic bone mass following primary total hip arthroplasty

Conditions: Osteoarthritis

Summary: total hip replacement is a common procedure for the treatment of osteoarthrosis of the hips, the aims of this study are to determine the effect of implant stem design on bone quality surrounding the implant using three stem designs that are routinely implanted at this hospital.

120 patients will undergo routine hip replacements using either the c-stem, exeter stem or charnley stem implants. patients will be clinically evaluated pre-operatively and randomised to one of the three implants. post-operatively, patients will be clinically reviewed for 2 years using bone mineral density scans, radiological review, blood and urine analysis for bone markers and validated questionnaires to assess clinical data (oxford hip and harries hip). patients will be assessed for prothesis migration using the ebra methods.

Eligibility criteria:
inclusion criteria: * patients must be aged 60 yrs or more uncomplicated primary or secondary osteoarthritis of the hip undergoing unilateral cemented total hip arthroplasty using a metal on polyethylene bearing couple. exclusion criteria: * metabolic bone disorders, systemic disorders such as rheumatoid arthritis and patients who have taken pharmacological doses of oral steroids, hormone replacement therapy, tamoxifen, calcium or vitamin d supplements within the last year. patients with a prior history of bisphosphonates and women of child bearing age.

Keywords: aseptic loosening femoral stem design
fasting time effects in time-restricted eating (fate-tre)

Conditions: Healthy Diet; Fasting, Intermittent

Summary: over the past century, lifestyles and eating habits have rapidly changed, helping to increase the onset of conditions such as obesity, metabolic syndrome and the risk of cardiovascular and metabolic diseases such as diabetes. recently, dietary regimens such as calorie restriction and intermittent fasting have been promoted as new strategies for reducing obesity and related co-morbidities. these strategies have proven effective in reducing body fat, improving blood pressure, lipid profile and insulin resistance in overweight individuals. however, due to the rigidity of these food protocols, the adherence of subjects to the diet is often limited or maintained only for short periods. time-restricted eating (tre) is a less extreme form of intermittent fasting, in which the subject's daily calorie intake is consumed only in a certain period of time during the day (normally 8-12 hours). tre have been able to reduce fat mass, pro-inflammatory markers (eg il-6, tnf-a) and have improved some biomarkers related to cardiovascular risks (eg insulin, hdl, tg). the literature offers numerous versions of intermittent fasting, and the role of fasting duration is not yet fully clear. thus. the aim of the present study is to investigate the effect od different duration of fasting in a tre protocol on body composition and lipid and inflammatory profile. moreover, the study intended to explore the effect of 2 month of tre on long term maintenance of diet habits, body composition, lipid and inflammatory profile.


Eligibility criteria:
inclusion criteria: * bmi between 18-30 kg/m2 * stable body weight for at least 3 months exclusion criteria: * type 2 diabetes or pre-diabetes for ada guidelines * significant chronic disease * recent and acute inflammatory status * recent (within 3 months) treatment with anabolic steroids, systemic corticosteroids or estrogen. * regular exercise training (≥ 2 sessions/week) or ≥ 10,000 steps/day

Keywords: time restricted eating intermitted fasting body composition metabolism inflammation
electroacupuncture preconditioning on geriatric noncardiac surgery

Conditions: Coronary Heart Disease

Summary: the purpose of this study is to observe whether the electroacupuncture (ea) preconditioning for five days before operation can improve the outcomes of patients with coronary heart disease undergoing geriatric non-cardiac surgery.

background: with the development of surgical techniques, more and more people with coronary heart disease underwent non-cardiac surgery, which include abdominal, urologic, orthopedic surgeries. due to the vulnerable heart function, geriatric patients suffer high incidence of cardiovascular events during the peri-operative period. some studies found that ea preconditioning have a protective effect for the patients underwent cardiac surgery. but non one addresses the effects of ea preconditioning on the outcomes of the patients with coronary heart disease who undergo non-cardiac surgery. designing: the patients with coronary heart disease who will receive abdominal surgery will be randomly assigned into ea preconditioning group and control group. the patients in ea preconditioning group was treated at bilateral neiguan (pc 6)，lieque (lu 7) and yunmen (lu 2) with electrical stimulation (5-30 hz，2．34-6．24 ma，30 min) for 5 consecutive days before surgery．before operation and before surgery, after surgery, 24h, 72h post surgery, all patients will be subjected to test the serum level of c-reactive protein and troponin i. the eeg and heart ultrasonic exam will be used to evaluate the condition and function of heart before and after surgery.

Eligibility criteria:
inclusion criteria: * elective abdominal surgery with coronary heart disease exclusion criteria: * serious bradycardiac arrythmia

Keywords: electroacupuncture preconditioning non-cardiac surgery coronary heart disease
regulated cannabis access in basel

Conditions: Cannabis Use Disorder; Mental Health Disorder; Physical Illness

Summary: the randomised controlled study on regulated cannabis access in pharmacies in basel aims to investigate the effects of regulated cannabis access on consumption behaviour and mental and physical health in comparison to the illegal market.

this project consist of two parts: the first part is a randomised controlled study, the second part is an observational study. the randomised controlled study will last six months. participants will randomly be assigned to one of two groups: group 1 has immediately access to regulated cannabis in pharmacies; group 2 has to wait for six months. after six months all participants will have access to regulated cannabis in pharmacies (oberservational study). every six month participants will be invited to answer online-questionnaires on their cannabis consumption behavior, their mental and physical health. the entire study lasts 2.5 years.

Eligibility criteria:
inclusion criteria: * at least 18 years, residence in basel-stadt, consuming cannabis at least monthly during the last 6 months (positive urine sample) exclusion criteria: * pregnant or breastfeeding, currently suicidal, currently psychotic, current inpatient psychiatric treatment

Keywords: cannabis regulation health effects cannabis consumption
prostate olaparib real world evidence study

Conditions: Metastatic Castration-resistant Prostate Cancer

Summary: this french non-interventional prospective multicenter cohort study is conducted to study the added value of olaparib in the treatment of patients with mcrpc in the real world setting in terms of treatment sequencing, effectiveness, safety and brca testing patterns and thus inform future clinical practice.


Eligibility criteria:
inclusion criteria: * adult male patients (≥ 18 years old) * with metastatic castration-resistant prostate cancer - who have initiated olaparib within the last two months of study entry, or for whom the decision to be treated with olaparib has been made by their physician * who have been informed and are not opposed to this data collection exclusion criteria: * patients opposed to the collection of their data * patients participating in a clinical trial with an investigational prostate cancer targeted drug within 30 days prior to olaparib initiation
smartphone twelve lead electrocardiogram utility in st-elevation myocardial infarction

Conditions: ST Segment Elevation Myocardial Infarction

Summary: the primary objective of this study is to determine if the smartphone electrocardiogram (ecg) is an acceptable replacement for a standard ecg in the identification of st elevation myocardial infarction (stemi). toward this objective, this study involves the following: * obtain simultaneous recordings of a standard 12-lead ecg and the iphone "12-lead equivalent" ecg on patients presenting with chest pain in which the stemi protocol was activated. * obtain simultaneous recordings of a standard 12-lead ecg and the iphone "12-lead equivalent" ecg on patients presenting to the emergency department for evaluation of chest pain, not necessarily presenting with stemi. * reading of ecgs (standard 12-lead and iphone) by three independent cardiologists, who are blinded to the initial clinical ecg readings, the type of ecg equipment used, and the patient's clinical information. * assess the operational feasibility of using the smartphone to obtain "12-lead equivalent" ecg recordings in patients suspected to have stemi, and * determine the possibility of pooling the data obtained from this study with data from other institutions conducting identical studies, and developing a future irb-approved protocol and statistical analysis plan to compare the sensitivity, specificity, positive predictive value and the negative predictive power of the iphone ecg, using a paired standard 12-lead ecg as the gold standard. there will be no therapeutic interventions. a single research-related procedure will be required, i.e. an iphone ecg. effort will be made to ensure that the performance of this procedure will not delay any treatment and/or diagnostic procedures that are part of usual or specialized care that the patient requires. effort will be made to enroll 1 stemi patient for every 2 non-stemi patients.


Eligibility criteria:
inclusion criteria: * male or female \>= 18 years of age. * ability to understand and sign a written informed consent form, which must be obtained prior to initiation of any study procedures (patient or legally acceptable representative). * symptoms of chest pain upon presentation at the intermountain medical center emergency department. exclusion criteria: * inability or refusal of the patient and/or the patient's legally-acceptable representative to provide written informed consent for any reason. * other conditions that in the opinion of the principal investigator or co-investigator(s) may increase risk to the subject and/or compromise the quality of the clinical trial.
mri- guided transurethral ultrasound ablation of localized prostate cancer

Conditions: MRI Guided Transurethral Ultrasound Ablation; Localized Prostate Cancer; Ablation Therapy

Summary: primary purpose : evaluation of the efficiency and safety of an alternative global prostate treatment in localized prostate cancer. primary objective: absence of clinically significant cancer (csc) on control biopsy at 1-year follow-up. secondary objectives: 1. biochemical response 2. presence of any csc on biopsy at 1- and 2-year follow-up 3. radical treatment free survival 4. adverse events, clinical tolerance 5. urinary continence 6. erectile function 7. quality of life


Eligibility criteria:
inclusion criteria: * male patient ≥ 50 years old * histologically confirmed adenocarcinoma of the prostate * gleason ≤ 7 (3 + 4) ; grade group ≤ 2 according to epstein * clinically \<t3, n0, m0 * psa \< 15 ng/ml * prostate volume \<100g * eastern cooperative oncology group (ecog) performance status of 0-1 * life expectancy higher than 12 months in the judgement of the investigator * radiological tnm (prostate mri) t ≤ 2 (absence of extra-capsular extension, absence of seminal vesicle invasion), n = 0, m = 0 * first line of treatment or relapse after initial radiotherapy * willing to give signed, informed consent freely * able to adhere to the follow-up schedule and other protocol requirements. exclusion criteria: * contraindication to mri * contraindication to general anesthesia * presence or history of any other malignancy except for non-melanoma skin cancer adequately treated at least 2 years before study entry * unreversible haemostasis disorder
dexmedetomidine infusion in hypospadias surgery

Conditions: Pain

Summary: the investigators hypothesize that giving dexmedetomidine in combination with fentanyl for pediatric patients undergoing hypospadias surgery, will reduce the fentanyl requirement for intraoperative and postoperative analgesia.


Eligibility criteria:
inclusion criteria: * children aged 1-12 years undergoing hypospadias repair exclusion criteria: * allergy to dexmedetomidine * preoperative use of sedatives or analgesics * cardiac diseases * children with mental retardation

Keywords: dexmedetomidine fentanyl pain pediatrics
assessment of preoxygenation strategies in the prehospital environment

Conditions: Anesthesia; Hypoxia

Summary: comparison of the preoxygenation efficacy of tidal volume breathing using three different preoxygenation techniques which are available to providers in the prehospital environment.

prospective randomised interventional study. healthy volunteers will be positioned supine and undergo preoxygenation by tidal volume breathing for 3 minutes using each technique in turn. the sequence of techniques for each volunteer will be randomised in advance. investigators will be instructed to ensure a good mask seal throughout the testing period. at the end of a 3 minute preoxygenation period, after a brief breath hold, the volunteer will exhale into reservoir tubing, allowing the fractional expired oxygen concentration (feo2) to be determined (primary outcome) using a calibrated gas analyser. the techniques being assessed have been chosen from methods of preoxygenation commonly available to clinicians in the prehospital environment: 1. continuous positive airway pressure mode with fractional inspired oxygen concentration (fio2) 100% using a portable ventilator. 2. bag-valve-mask device (bvm) with 15 l/min oxygen flow. 3. non-rebreather mask (nrm) device with 15 l/min oxygen flow. volunteers will also be asked to indicate the subjective ease of breathing for each technique (secondary outcome) using a visual analogue scale (vas).

Eligibility criteria:
inclusion criteria: * adult volunteers exclusion criteria: * pregnancy * respiratory disease * bearded * facial abnormality * edentulous

Keywords: oxygen inhalation therapy intubation emergency medicine
impact of pyloric injection of magnesium sulfate and lidocaine mixture on outcome after sleeve gastrectomy

Conditions: Morbid Obesity

Summary: postoperative nausea and vomiting is a common adverse effect after sleeve gastrectomy, mostly due to increased intragastric pressure. the present trial aimed to assess the effect of pyloric injection of mixture of magnesium sulfate and lidocaine on postoperative gastric intraluminal pressure and incidence of nausea and vomiting.


Eligibility criteria:
inclusion criteria: * patients that aged between18 and 65 years. * american society of anesthesiologists (asa) class i - iii. * morbidly-obese patients who failed to achieve and maintain a clinically significant weight loss through supervised non-surgical methods for at least 6 months. * surgery was conducted as the first line of treatment in case of patients with bmi ≥ 50 kg/m2 (super obese). exclusion criteria: * obesity secondary to endocrine disorders. * history of any previous bariatric procedure. * impaired intellectual capacity or major psyciatric disorder. * sweet eaters who would not adopt a change of postoperative eating habits. * lack of willingness and motivation to embrace postoperative lifestyle changes. * substance abuse. * pregnancy or expected pregnancy in the following 12 to 18 months. * severe gastroesophageal reflux disease
effect of exercises on dentists' body functions

Conditions: Neck Pain

Summary: the aim of the study is to compare the effects of supervised exercises, video based exercises and control group on muscle strength, muscle endurance, pain and upper extremity function in dentists with musculoskeletal pain. participants were randomly divided into 3 groups: supervised exercise group (seg), video based exercise group (veg) and control group (cg). both seg and veg were given same exercises but seg did the exercises with a experienced physiotherapist while veg did it through videos 3 days a week for 12 weeks. cg was only given postural education.


Eligibility criteria:
inclusion criteria: * working as an active dentist for at least 3 years * having nonspecific neck pain more than 3 months exclusion criteria: * any operation in neck area

Keywords: muscle strength muscle endurance pain neck pain musculoskeletal problems
intravenous subdissociative-dose ketamine versus morphine for prehospital analgesia

Conditions: Pain Management

Summary: this is a prospective, randomized, single-blind trial evaluating prehospital patients experiencing moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5. patients will be randomized to receive ketamine at or morphine by intravenous push.

this study is designed to evaluate if ketamine alone is non inferior to morphine alone for prehospital analgesia. numeric rating scale pain scores will be compared between recipients of ketamine and recipients of morphine at 15, 30, 45 and 60 min post first injection and at hospital admission.

Eligibility criteria:
inclusion criteria: * older than 18 years old * prehospital moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5 exclusion criteria: * unstable vital signs (systolic blood pressure \ 200 mm hg, pulse rate \ 150 beats/min, and respiration rate \ 30 breaths/min) * pregnancy * breast-feeding * altered mental status * unable to give numeric rating scale scores * allergy to morphine or ketamine * acute pulmonary edema * acute coronary syndrome * renal or hepatic insufficiency * patient who received morphine for the same acute pain * acute psychiatric illness

Keywords: morphine ketamine acute pain prehospital