Kornimate/medical-research-clean huggingface dataset:
cognition, age, and rapamycin effectiveness - downregulation of the mtor pathway

Conditions: Cognitive Impairment, Mild; Alzheimer Disease

Summary: evaluation of central nervous system penetration of orally administered rapamune (rapa) in older adults with mild cognitive impairment (mci) or early alzheimer's disease (ad) and investigate associated safety, tolerability, target engagement, cognition, and functional status as initial proof-of-concept study

this study is an open-label pilot study of orally administered rapa to measure its target engagement in cerebrospinal fluid (csf) and blood, and to establish the feasibility and safety of rapa treatment in older adults with mci and early stage ad as initial proof-of-concept for a larger phase 2 clinical trial.

Eligibility criteria:
inclusion criteria: * diagnosis of mild cognitive impairment (mci) or alzheimer's disease, global clinical dementia rating scale (cdr)=0.5-1 * normal blood cell counts without clinically significant excursions; ; normal liver and renal function; and glucose control (hba1c \< 6.5%). lipid panel and pt/ptt/inr within normal limits * a legally authorized representative (lar) if necessary for consent * an lar or study partner to accompany participant to all visits * availability for all study visits * stable dose of ad medications) donepezil, rivastigmine, memantine, galantamine) for at least 3 months prior to the baseline visit exclusion criteria: * diabetes (hba1c≥6.5% or anti-diabetic medications) * history of skin ulcers or poor wound healing * current tobacco or illicit drug use or alcohol abuse * use of anti-platelet or anti-coagulant medications other than aspirin * current medications that affect cytochrome p450 3a4; current or recent medications for hypertriglyceridemia (eg, gemfibrozil) * hypersensitivity or history of allergy to rapamycin * immunosuppressant therapy within the last year; current treatment with hydroxychloroquine and chloroquine (requires "washout period" of 14 days) * chemotherapy or radiation treatment within the last year * current or chronic history of liver disease or known hepatic or biliary abnormalities * history of primary hypertriglyceridemia. abnormal triglycerides \>200 or ldl cholesterol \>193, or other abnormal labs deemed clinically significant upon investigator review * current or chronic history of pulmonary disease or abnormal pulse oximetry (\<90%) * chronic heart failure * pregnancy * recent history (past 6 months) of myocardial infarction, active coronary artery disease, intestinal disorders, stroke, or transient ischemic attack * significant neurological conditions other than ad * poorly controlled blood pressure (systolic bp\>160, diastolic bp\>90mmhg) * active inflammatory, covid-19, autoimmune, infectious, hepatic, gastrointestinal, malignant, and/or psychiatric disease * history of, or magnetic resonance imaging (mri) positive for any space occupying lesion, including mass effect and/or abnormal intracranial pressure, which would indicate contraindication to lumbar puncture * organ transplant recipients
does ultraviolet irradiation reduce platelet reactivity and improve coronary microvascular function in man?

Conditions: Hypertension

Summary: endothelium derived nitric oxide (no) regulates vascular tone and blood pressure in man. no also inhibits platelet aggregation and mediates a variety of beneficial anti-inflammatory and repair mechanisms. no may also be a mediator in the release of the endogenous fibrinolytic factor, tissue-plasminogen activating factor (t-pa) from the endothelium.1 via these actions it plays a very important role in protection of the vasculature from atherothrombosis and clinical sequelae such as myocardial infarction and stroke. visible and ultraviolet (uv) light relax vascular smooth muscles by producing no in a phenomenon known as photorelaxation.2 the investigators have demonstrated significant stores of pre-formed, bound no and other nitrosospecies in human skin, which are rapidly released upon exposure to uva.3 the investigators have demonstrated recently that serum nitrite and nitroso-species are increased after standing in a uva phototherapy cabinet and that local uva exposure is associated with increased forearm arterial blood flow that is independent of skin temperature. the investigators have also demonstrated a fall in mean arterial blood pressure in subjects exposed uva. cardiovascular morbidity and the prevalence of hypertension vary with latitude. the investigators hypothesise that some of this geographical variation may be explained by a diminished sunlight/uva exposure with attendant negative effects upon no bio-availability.4 to further examine the potential beneficial effects of uva exposure we will examine the effects of whole-body uva upon platelet activation and upon myocardial/coronary arterial flow reserve. the investigators will correlate these measures with systemic nitrate, nitrite and nitroso-species content in healthy volunteers. hypotheses 1. uva irradiation enhances coronary flow reserve in healthy volunteers. 2. uva irradiation suppresses platelet activation in healthy volunteers. 3. uva irradiation enhances the release of endogenous fibrinolytic factors in healthy volunteers.


Eligibility criteria:
inclusion criteria: * healthy male volunteers aged between 18-45 years (inclusive). exclusion criteria: * inability to provide informed consent * co-existent systemic disease (including any history of asthma, reactive airways disease or hypertension) * contraindication to uva treatment * any history of cardiac conduction abnormality (including bundle branch block or atrial fibrillation) * smoker * current intake of aspirin, other non-steroid anti-inflammatory medications or any regular medication. * recent infective/inflammatory condition * echocardiographic evidence of left ventricular hypertrophy (left ventricular septal diameter \>1.2 cm in diastole), systolic dysfunction or significant valvular stenosis or regurgitation.

Keywords: hypertension uv radiation coronary flow reserve nitric oxide
real world assessment of people living with chronic hepatitis b in australia

Conditions: Hepatitis B

Summary: the reach-b study establishes an observational cohort study of people living with chronic hepatitis b from a national network, including a diverse range of services, to characterise and monitor hepatitis b linkage to care and treatment requirements amongst this population.

participants presenting to participating clinics for hbv care within the previous 12 months will be identified and enrolment data will be collected including demographics, laboratory parameters, liver disease assessment, treatment history and clinical management. follow-up data on hbv treatment and clinical management, liver disease stage and laboratory parameters will be collected at each subsequent visit or at minimum every 12 months.

Eligibility criteria:
inclusion criteria: 1. all individuals diagnosed with chronic hepatitis b in the participating study sites are eligible to be included (both newly diagnosed cases and those diagnosed in the past). 2. 16 years of age or older. 3. attended the health service for hbv care within the prior 12 months from study commencement (retrospective recruitment) or attending the health service for hbv care from study commencement (prospective recruitment) exclusion criteria: 1. nil
prevention of energy deficit syndrome in female athletes. molecular mechanisms associated with malnutrition.

Conditions: Female Athlete Triad; Energy Deficit Syndrome; Mediterranean Diet; Red Fruits; Antioxidative Stress; Nutritional Disorder; Sports Physical Therapy

Summary: energy deficit syndrome (red-s) is the impairment of physiological functioning caused by relative energy deficiency and includes impaired metabolic rate, menstrual, endocrine, hematological, immunological, gastrointestinal, bone, psychological, developmental and cardiovascular function. eighty-seven percent of athletes show at least one symptom related to red-s, with a higher prevalence in women. treatment of red-s preferably involves a multidisciplinary team of health professionals to address the complex interaction of nutrition, training, body image and performance. the main objective is to prevent energy deficit syndrome in female athletes in the province of alicante through different training and diet protocols using a virtual platform. a 12-week single-blind randomized clinical trial with an intervention period and a control period (rct) is proposed. the sports federations of the most representative practices in the province of alicante will be selected by randomized sampling. the female athletes will be randomly divided into 4 groups (control group; control group with free use of the virtual platform; intervention group with mediterranean diet and physical exercise planning; intervention group with red fruits and physical exercise planning).


Eligibility criteria:
inclusion criteria: * (a) exercise at least 3 days/week, * (b) not having any diagnosed chronic pathology or ailment that prevents physical exercise or following nutritional guidelines rich in antioxidants. exclusion criteria: - all individuals taking medication that could affect the results of the study will be excluded from the study.
piloting movement-to-music with arm-based sprint-intensity interval training among children with physical disabilities

Conditions: Cerebral Palsy

Summary: this study is investigating the potential effects of a high-intensity home-exercise program among children with cerebral palsy. the program includes rhythmic movements to music that are adapted for wheelchair uses and age-appropriate themes. this project has the potential to address a large knowledge gap in the extant literature, because there are no widely accessible, evidence-based, enjoyable, and age-appropriate modalities for improving cardiovascular fitness or cardiometabolic health among children with disabilities who have mobility disabilities.


Eligibility criteria:
we are recruiting 50 parent-child dyads. childs are the participant undergoing the exercise intervention. parents are required to support the safety and schedule of the child participant. parents are considered participants due to their responsibilities. inclusion criteria: * have a medical diagnosis of cerebral palsy, as determined by icd-10 codes * aged 6-17 years old * a gross motor function classification system level i-iii (as determined via participant screening, explained in the protocol section below) * medical clearance to participate in high-intensity exercise from a physician (using the attached medical screening form and explained in the intervention safety, monitoring, and response plan) * access to a wi-fi internet connection in the home via mobile phone or tablet computer * a caregiver who will support and monitor the participant's safety during the intervention and manage the child's exercise schedule. exclusion criteria: * physically active (defined as \>150 minutes per week of self-reported moderate-to-vigorous intensity exercise in a typical week) * cannot use their arms for exercise * a gross motor function classification level of iv-v * complete blindness or deafness; * any past history of a contraindication to exercise testing according to american college of sports medicine (acsm) guidelines (liguori and american college of sports medicine, 2020): significant change in the resting electrocardiogram suggesting significant ischemia, myocardial infarction, or other cardiac event, unstable angina, uncontrolled cardiac dysrhythmias causing symptoms or hemodynamic compromise, symptomatic severe aortic stenosis, uncontrolled symptomatic heart failure, pulmonary embolus or pulmonary infarction, myocarditis or pericarditis, aneurysm. * pregnant (due to radiation from a dual energy x-ray absorptiometry \[dexa\] scan) * has not been seen by a physician within the last year * uses a g-tube eligible caregivers will include parents or legal guardians of the child, who can commit sufficient time to support the child in their roles for the study and communicate in english. caregivers who have complete blindness or deafness will be excluded from participation.
environment analysis inside an investigational prescription bottle

Conditions: Chronic Pain

Summary: the purpose of the study is to test a research prescription bottle that will monitor the physical environment inside the bottle.

the purpose of the study is to test a research prescription bottle that will monitor the physical environment inside the bottle. the participant will be asked to keep the medication in the bottle and to remove each pill immediately before taking it. the participant will not store medications in pill organizers, other pill bottles, pockets, purses, etc. the participant will keep a record of when the participant removes a pill from the bottle and takes it. certain aspects of this study will be withheld from the participant to preserve the integrity of the study. this information will be revealed at the conclusion of the study.

Eligibility criteria:
inclusion criteria: * chronic pain \> 3 months duration * major source of pain is due to low back pain diagnosis * prescribed only one type of opioid: hydrocodone 10mg/325 mg acetaminophen * last urine drug study was done between 6-12 months ago * will have a return to clinic visit in 3 months exclusion criteria: * concurrent use of other opioids * use of intrathecal device * use of spinal cord stimulator * presence of pain due to cancer, chemotherapy, radiation treatment and/or cancer related surgery * dementia * illiteracy
comparative study evaluating the effect of vitamin k1 versus vitamin k2 on vascular calcification in dialysis patients

Conditions: End Stage Renal Disease on Dialysis

Summary: to evaluate the effect of supplementation of vitamin k2 (menaquinone, mk-7)vs vitamin k1 on circulating levels of calcification regulators and to assess their safety in patients on regular dialysis patients.

vascular calcification has emerged as an independent risk factor for cardiovascular morbidity and mortality, especially in chronic kidney disease . it has a predictive value of poor prognoses and clinical outcomes in ckd patients such as overall mortality and even poor arteriovenous graft maturation . vitamin k is essential for the activation of matrix gla protein (mgp), a powerful inhibitor of tissue calcification, functional vitamin k deficiency may contribute to high vascular calcification (vc) burden in haemodialysis patients; this is process in which mineral is pathologically deposited in blood vessels, mainly in large elastic and muscular arteries such as the aorta and the coronary, carotid, and peripheral arteries. it is prospective, randomized,placebo controlled study

Eligibility criteria:
inclusion criteria: 1. both sexes aged between 18-75 years 2. patients on hd greater than 3 months at least. 3. stable clinical condition (no hospitalization in the previous 3 months) exclusion criteria: 1. hypersensitivity to vitamin k 2. participant in an another clinical trial within the past 4 weeks. 3. judged to be unsuitable as a subject by the attending physician. 4. patients taking warfarin 5. patients with known intestinal malabsorption 6. patients with hypercoagulable state
circumcision with a novel disposable device in chinese children: a hospital-based randomized controlled trail

Conditions: Circumcision

Summary: circumcision, a removal of the foreskin, is performed commonly at any age in male worldwide. globally over 25% of men are circumcised. in the middle east, circumcision is even performed routinely in every male newborn. the benefits from it vastly outweigh the risks. gradually, more and more chinese male are willing to undergo it with themselves and their sons. but there are also some complications with circumcision, such as pain, edema, infection, and hemorrhage. considering of that, physicians continually manage to improve their surgical methods and analgesic techniques. in the study of peng, a disposable minimally invasive circumcision anastomosis device named shenghuan (china wuhu snnda medical treatment application technology co. ltd.) (shd) was introduced to be applied in circumcision. and they concluded that method was quicker, safer and less pain than the conventional techniques of incision. in present study, we carry out a randomized controlled trail, using a different method as peng introduced with this device in children's circumcision (yan's), compared with the method as peng used and the conventional technique in our hospital, and then observe the outcomes.


Eligibility criteria:
inclusion criteria: * children with phimosis or redundant prepuce exclusion criteria: * children with genital tract infection or deformity, * congenital diseases, * hematological diseases, * or other general diseases

Keywords: circumcision, chinese children, pain
treatment of late-life anxiety in primary care settings

Conditions: Generalized Anxiety Disorder; Panic Disorder; Anxiety Disorder Not Otherwise Specified

Summary: the research study proposed is designed to examine the outcomes of a cognitive behavioral guided self-care intervention with older adults diagnosed with generalized anxiety disorder and recruited from a primary care setting. it is hypothesized that the cognitive behavioral guided self-care intervention will produce greater declines in worry and anxiety than enhanced usual care.


Eligibility criteria:
inclusion criteria: * age ≥ 60 years * a dsm-iv diagnosis of gad * able to read english. exclusion criteria: * current psychotherapy * a dsm-iv diagnosis of alcohol or substance abuse * a diagnosis of dementia or global cognitive impairment operationalized as a score of \< 24 of the mini-mental status examination * psychotic symptoms * active suicidal ideation
sixteen years trends in reported undernutrition in switzerland

Conditions: Malnutrition; Epidemiology

Summary: to assess 16-year trends in undernutrition reporting and management in switzerland

analysis of data from the swiss hospital discharge databases between 1998 and 2014. the database was provided by the swiss federal office of statistics (http://www.bfs.admin.ch); it covers 98% of public and private hospitals within switzerland and includes all stays for each hospital.

Eligibility criteria:
inclusion criteria: * adult patients (aged ≥20 years), length of hospital stay \>1 day, not having any icd-10 codes related to pregnancy, childbirth and puerperium (i.e. icd-10 codes beginning with letter "o") as main diagnosis, and having complete demographic data and information on main diagnosis and mortality exclusion criteria: -
2018 intern health study micro-randomized trial

Conditions: Depression; Mood; Sleep; Physical Activity

Summary: the aim of this trial is to evaluate the efficacy of an intervention (delivered through a smartphone) for improving the mood, physical activity, and sleep of medical interns.

due to their high stress workloads, medical interns suffer from depression at higher rates than the general population. interns also tend to have lower sleep and decreased physical activity. the goal of this trial is to evaluate the efficacy of a mobile health intervention intending to help improve the mental health of medical interns. the intervention sends mobile phone notifications which aim to help interns improve their mood, maintain physical activity, and obtain adequate sleep during their internship year. the primary aim of the study is to evaluate how notifications affect participants' weekly mood, as measured through a daily one question mood survey. the second primary aim of the study is to evaluate how notifications affect participants' long-term mental health, as measured by the patient health questionnaire. the first secondary aim is to evaluate how mood notifications affect participants' weekly mood. the second secondary aim is to evaluate how activity notifications affect participants' weekly step count. the third secondary aim is to evaluate how sleep notifications affect participants' weekly sleep duration. in order to better optimize notification delivery, the final aim (exploratory) is to understand moderators of these effects. moderators of interest are previous week's mood, previous week's step count, previous week's sleep duration, study week, sex, previous history of depression, and baseline neuroticism.

Eligibility criteria:
inclusion criteria: * medical intern during the 2018-2019 internship year * iphone user * affiliated with one of 47 recruitment institutions * downloaded app, completed consent, and filled out baseline survey prior to june 25th 2018 exclusion criteria: -none
a phase iii trail of adjuvant chemoradiotherapy versus adjuvant radiotherapy in esophageal squamous cell carcinoma

Conditions: Esophageal Cancer

Summary: this is a multicenter, randomized, open-label, phase iii trail comparing adjuvant chemoradiotherapy (paclitaxel and carboplatin) to adjuvant radiotherapy in patients undergoing radical esophagectomy for pathologic lymph node positive esophageal squamous cell carcinoma.

patient population: age: 18-70y; thoracic esophageal squamous cell cancer undergoing radical esophagectomy; clinical stage t1-4, n1-3, m0; eastern cooperative oncology group (ecog) score: 0-1; the patients are randomized to 2 arms. arm a: adjuvant radiotherapy (50.4gray/28fraction) followed by chemotherapy (paclitaxel and carboplatin) 4 cycles. arm b :adjuvant radiotherapy (50.4gray/28fraction) only

Eligibility criteria:
inclusion criteria: 1. histologically documented squamous cell carcinoma of the thoracic esophagus; undergoing radical esophagectomy; the pathological stage is t(primary tumor)1-4 n(regional lymph nodes)1-3 m(distant metastasis)0 (esophagus, union for international cancer control(uicc) 2010) ; 2. untreated (e.g. radiotherapy, chemotherapy, target therapy and immunotherapy); 3. the expectation of life is more than 6 months; 4. age: 18\~70 years old; 5. normal hemodynamic indices before the recruitment (including white blood cell count\>4.0×109/l, neutrophil count\>1.5×109/l, platelet count \>100×109/l, hemoglobin≥90g/l, normal liver/kidney function); 6. ecog (eastern cooperative oncology group) : 0-1; 7. able to understand this study and have signed informed consent. exclusion criteria: 1. have been treated with chemotherapy, radiotherapy and other anti tumor treatment except surgery; 2. known or suspected of allergy to paclitaxel or carboplatin; 3. female in pregnancy or lactating; 4. with significant psychological, family, social and other factors which may affect the ability to understand and sign the informed consent; 5. patients with peripheral neuropathy(ctc grade≥2); 6. with other malignant tumors before the recruitment. 7. the researchers consider that the patient is not appropriate to enroll the study; 8. the patient can't be tolerant to postoperative adjuvant radiotherapy and chemotherapy for serious heart/lung/liver/kidney function, the haematopoietic system diseases, the immune system diseases, the nervous system diseases, cachexia and so on.

Keywords: esophageal cancer;adjuvant therapy;chemotherapy;radiotherapy