Kornimate/medical-research-clean huggingface dataset:
needs assessment evaluating quality of life issues for gastroparesis patients and caregivers

Conditions: Gastroparesis

Summary: the project will involve conducting a needs assessment for gastroparesis patients and their caregivers with the goal of identifying quality of life issues associated with this disease. identifying these issues will ameliorate management and support systems for gastroparesis currently existent in the community and, hopefully, provide information for the establishment of more resources to assist the patients and their families.

this project will involve: a) distributing questionnaires to up to 200 participants (100 patients and 100 caregivers) at the shands gastrointestinal clinic and b) focus groups including patients, medical provider, and the clinic case manager. the questionnaires will provide information on the relative effect of gastroparesis on the quality of life of the patients and their caregivers. assessment of this needs assessment will then help identify areas of potential resource improvement and mobilization to provide support for the patients and their family members.

Eligibility criteria:
inclusion criteria: * gastroparesis patients at the gi clinic of shands hospital at the university of florida * caregivers to gastroparesis patients at the gi clinic of shands hospital at the university of florida exclusion criteria: * inability to fill out the questionnaires by any cause

Keywords: gastroparesis quality of life
sprint performance in football players with a previous hamstring injury

Conditions: Sprint Performance; Hamstring Injury

Summary: few studies indicate that sprint performance may be impaired in football players with a previous hamstring strain injury. this exploratory cross-sectional study aim to compare sprint performance between football players with and without a previous hamstring strain injury. the findings may elucidate potential indications of insufficient rehabilitation following a hamstring strain injury. sprint performance data will be collected using the mysprint iphone application. due to pragmatic reasons and the exploratory nature of this study the aim is to include players on a team level. based on the prevalence of hamstring strain injuries the expected number of cases to be included are 10-20 football players with a previous hamstring strain injury, and a corresponding 80-90 number of healthy controls. no outcomes will be weighted (flat outcome structure).


Eligibility criteria:
inclusion criteria controls: * able to participate fully in regular football training and matches exclusion criteria controls: * self-reported hamstring strain injury resulting in loss of regular football training sessions or football matches in the preceding 12 months. * longstanding injury (\>6 weeks) in the lower extremities or trunk in the preceding 12 months. * any pain in the lower extremity, pelvis, or spine during testing inclusion criteria cases: * able to participate fully in regular football training and matches * self-reported hamstring strain injury resulting in loss of regular football training sessions or football matches in the preceding 12 months. exclusion criteria cases: * longstanding injury (\>6 weeks) in the lower extremities (except hamstring strain injury) or trunk in the preceding 12 months. * any pain in the lower extremity, pelvis, or spine during testing
vision testing in patients with partial seizures receiving either lyrica or placebo

Conditions: Epilepsies, Partial

Summary: patients with partial seizures currently taking 1-3 antiepileptic medications will have a 50:50 chance to receive lyrica 300 mg per day or placebo (no active ingredients) added on to their current medications for 3 months. neither the study doctor nor the patient will know the medication assignment. vision testing will be performed prior to receiving the study treatment and at the end of the study to see if there are any changes.


Eligibility criteria:
inclusion criteria: * epilepsy partial seizure subjects. * currently taking 1 to 3 antiepileptic drugs. exclusion criteria: * pre-existing eye diseases (glaucoma). * insufficient response to pregabalin in the treatment of partial seizure, or patients currently receiving pregabalin treatment.

Keywords: epilepsy partial seizure treatment with pregabalin or placebo vision testing
pd-1 antibody, chidamide, lenalidomide and etoposide for relapsed or refractory nk/t cell lymphoma

Conditions: NK/T Cell Lymphoma

Summary: to observe the safety, tolerability and clinical effects of pd-1 antibody, chidamide, lenalidomide and etoposide in relapsed or refractory nk/t cell lymphoma.

this is a prospective, open-label, one-arm, multicenter clinical trial, aimed to evaluate the safety, tolerability, and efficacy of pd-1 antibody, chidamide, lenalidomide and etoposide in relapsed or refractory nk/t cell lymphoma. a total of 50 patients are planned to be enrolled into the study. the primary end points are objective responder rate (orr) and progression free survival(pfs) and the secondary end points include overall survival(os) , and adverse events.

Eligibility criteria:
inclusion criteria: 1. age:14-65 years;eastern cooperative oncology group (ecog)score≤2;expected survival≥3 months; 2. patients with nk/t cell lymphoma diagnosed by immuno-histochemistry (ihc) or fluorescence in situ hybridization (fish); 3. refractory or relapse after at least 2 regimen; 4. once the patient received radiotherapy, need to be more than 3 months away from this treatment, and it is a non-primary recurrence; 5. no chemotherapy contraindications: hemoglobin ≥ 100g / l, absolute neutrophil count ≥ 1.5 × 109 / l, platelets ≥ 80 × 109 / l, alt, ast ≤ 2 times the upper limit of normal, serum total bilirubin ≤ 1.5 times normal upper limit, serum creatinine ≥ 1.5 times normal upper limit, serum protein ≥ 30g / l; 6. at least one measurable lesion; 7. there are no other serious diseases that conflict with this program, and the cardiopulmonary function is normal; 8. women of childbearing age must have a negative urine or blood pregnancy test, and male patients should be contraceptive during medication; 9. there is no other antitumor treatment, but bisphosphonate for anti-bone metastasis treatment and other symptomatic treatment can be applied; 10. can understand the situation of this study and sign the informed consent voluntarily exclusion criteria: 1. rejecting providing blood preparation; 2. allergic to drug in this study or with hemophagocytic syndrome; 3. rejecting adopting reliable contraceptive method in pregnancy or lactation period; 4. uncontrolled internal medicine disease(including uncontrolled diabetes,severe incompetence cardiac,lung,liver and pancreas）； 5. with severe infection; 6. with primary or secondary central nervous system tumor invasion; 7. with chemotherapy or radiotherapy contraindication; 8. ever suffered with malignant tumor; 9. human immunodeficiency virus (hiv)-positive patients 10. drug abuse or long-term alcohol abuse that affects the evaluation of test results; 11. have peripheral nervous system disorder or mental disorder; 12. patients with immune system diseases; 13. those who have no legal capacity or whose research is affected by medical or ethical reasons;

Keywords: pd-1 antibody chidamide lenalidomide etoposide nk/t-cell lymphoma
combined physical and psychological intervention in carpal tunnel syndrome patients with nociplastic pain

Conditions: Carpal Tunnel Syndrome; Pain, Chronic

Summary: to assess the effectiveness of a combined physical and psychological intervention in reducing pain and improving function in carpal tunnel syndrome patients with nociplastic pain.


Eligibility criteria:
inclusion criteria: * adults aged 25-65 years * both sexes * diagnosis of carpal tunnel syndrome based on clinical examination and nerve conduction studies * presence of nociplastic pain as determined by the central sensitization inventory (csi) with a score ≥40 * positive tinel and phalen sign. exclusion criteria: * previous carpal tunnel release surgery * other musculoskeletal or neurological disorders affecting the upper extremity
assessment of pulmonary artery pressure and right sided hemodynamics in patients with osa before and after cpap ttt

Conditions: Obstructive Sleep Apnea of Adult

Summary: obstructive sleep apnea (osa) is a frequent sleep-related breathing disorder with an incidence of 5-20% in the middle-aged population in europe and northern america . plumonary hypertension is present in 12%-34% of patients with osa.continous positive air way pressureis the main standard treatment ofosa.echocardiograghy is the most common non invasive imaging method for assessment the effect on right ventricular function.

obstructive sleep apnea (osa) is a frequent sleep-related breathing disorder with an incidence of 5-20% in the middle-aged population in europe and northern america . pathophysiologic consequences of osa are increased sympathetic activity, hypoxia, hypercapnia, increased left ventricular after-load , acute arterial hypertension, increased diastolic and systolic pressure of the right ventricle, atrial dilation. recent studies have shown that osa is an independent risk factor for cardiovascular mortality and morbidity. osa has a social impact because of fragmentation of sleep leads to increased daytime sleepiness, decreased intellect, behavioral and personality changes, enuresis and sexual dysfunction. pulmonary hypertension is present in 12%-34% of patients with obstructive sleep apnea syndrome. when ph occurs as a consequence of osa however symptoms may not be present because of obesity and alack of physical exertion or symptoms of ph may be overlapped by other cardiovascular abnormalities. continuous positive air way pressure therapy is the main standard treatment of osa works the best in the most people as positive pressure ventilation functions as a pneumatic splint for the collapsing upper air way. echocardiography is the most common non invasive imaging method for assessment the effect of right ventricular function.

Eligibility criteria:
inclusion criteria: * moderate and severe osa and candidates for initiation of cpap therapy. exclusion criteria: * significant lung disease ,lfet sided heart failure,end stage malignancy and advanced organ failure.

Keywords: assessment pulmonary artery right sided hemodynamics patients sleep apnea syndrome contionous positive air way pressure treatment
sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy in uganda

Conditions: Intermittent Preventive Treatment; Placental Malaria

Summary: the effectiveness of sulfadoxine-pyrimethamine (sp) as intermittent preventive treatment in pregnancy in malaria-endemic areas the effectiveness and efficacy of sp may be compromised by increased sp resistance. this study will evaluate the efficacy of sp by giving sp to asymptomatic parasitemic pregnant women and following them to determine the rates of parasite clearance.


Eligibility criteria:
inclusion criteria: * 16-26 weeks gestation based on lmp or ultrasound or fundal height * axillary temperature \<37.5 degrees c * informed consent * hiv status known and negative * blood smear positive for falciparum malaria exclusion criteria: * history of hypersensitivity reaction to sp or components of sp * axillary temperature ≥37.5 degrees c * history of receipt of antimalarials or antibiotics with antimalarial activity\* in the past month * residence \> 30 km from the anc clinic or unwillingness to return for follow-up visits * hemoglobin level \< 5 gm/dl * these medications include all antimalarials, rifampin, doxycycline, clindamycin, tetracycline, erythromycin, azithromycin, chloramphenicol.

Keywords: malaria pregnancy
validation of a screening tool in geriatric oncology

Conditions: Breast Cancer; Colorectal Cancer; Head and Neck Cancer; Lung Cancer; Lymphoma; Prostate Cancer

Summary: rationale: a screening questionnaire may help doctors plan better treatment for older patients with cancer. purpose: this clinical trial is studying a questionnaire in screening older patients with cancer.

objectives: primary * validate a new screening tool (g8). secondary * validate the french version of the screening tool "vulnerable elders survey (ves-13)". * evaluate the merits of the screening tools (g8 and ves-13). * assess the screening tool in specific populations. * assess the number and type of interventions proposed after thorough geriatric assessment. * compare the two new tools (g8 vs ves-13). outline: this is a multicenter study. during the first consultation, patients have an initial clinical evaluation questionnaire comprising the g8. they also complete the self-questionnaire ves-13. within 30 days, patients have a thorough geriatric assessment, including quality of life and physical function, by a physician without access to the g8 or ves-13 questionnaires. a blood specimen is also collected. information on health status and quality of life is collected from medical records or from the doctor after 1 and 5 years.

Eligibility criteria:
disease characteristics: * histologically confirmed cancer including the following types: * colon * rectal * lung * squamous cell carcinoma of the head and neck * breast * prostate * non-hodgkin lymphoma * planning to undergo first-time treatment comprising medicine, surgery, or radiotherapy patient characteristics: * no persons deprived of liberty or under guardianship * no psychological, familial, social, or geographical reasons that would make monitoring clinically impossible prior concurrent therapy: * see disease characteristics

Keywords: colon cancer rectal cancer non-small cell lung cancer small cell lung cancer hypopharyngeal squamous cell carcinoma laryngeal squamous cell carcinoma laryngeal verrucous carcinoma lip and oral cavity squamous cell carcinoma oral cavity verrucous carcinoma nasopharyngeal squamous cell carcinoma oropharyngeal squamous cell carcinoma paranasal sinus and nasal cavity squamous cell carcinoma salivary gland squamous cell carcinoma prostate cancer breast cancer adult non-hodgkin lymphoma
low and conventional dose of somatropin in growth hormone deficient adult patients

Conditions: Growth Hormone Deficiency

Summary: an international study in which patients with ghd were randomized to receive somatropin at a dose of either 3 microg/kg/day or 6 microg/kg/day for the first three months. the dose was then doubled (6 microg/kg/day, ld or 12 microg/kg/day, cd) for the next three-months.


Eligibility criteria:
inclusion criteria: patients may be included in the study only if they meet all of the following criteria: 1. adult males and females with ghd, arising during adult life from pituitary ablation or failure, onset of ghd have taken place at least 1 year before entering the study, or, 2. adult males and females with ghd either idiopathic or secondary to pituitary disease arising in childhood. 3. demonstrated ghd as documented by a negative response to a standard gh stimulation test within the last 5 years previous year (see section 3.4.3, part b). maximal peak must be less than 3.0 ng/ml. 4. receiving replacement for other deficient hormones for at least 3 months prior to the start of the study, where necessary. 5. have given informed consent. exclusion criteria: patients will be excluded from the study for any of the following reasons: 1. patients with clinically significant pulmonary, cardiac, hepatic, renal or neuromuscular disease or with chromosomal or genetic malformation syndromes. 2. patients who have any evidence of an active tumorous process. intercranial lesions must be inactive and any antitumour therapy must be complete. 3. pregnant women and lactating females or women who decide to become pregnant during the study and who are not taking adequate contraceptives. 4. patients thought unlikely to comply with the protocol. 5. patients taking an investigational drug in the previous month.
insulin administration plus a telemedicine system (diabetes interactive diary - did) vs insulin plus common practice

Conditions: Type 1 Diabetes

Summary: the diabetes interactive diary (did) is both a cho (carbohydrates )/insulin bolus calculator, an information technology and a telemedicine system based on the communication between health care professional and patient by sms messages. aim of the study is to compare an insulin regimen of insulin glargine + prandial insulin glulisine associated with a telemedicine system to teach cho counting (did) with the same insulin regimen administered according to usual practice.


Eligibility criteria:
inclusion criteria: * individuals with type 1 diabetes as defined by the criteria of the expert committee on the diagnosis and classification of diabetes mellitus (29) * males and females * age equal or more than 18 years * patients not habitually using cho (carbohydrates) counting * self monitoring blood glucose (smbg) at least 3 times a day * four basal-bolus daily injections of short-acting and long-acting insulin analogues * hba1c equal or more than 7.5% * female patients have to be postmenopausal, hysterectomised or surgically sterilized or using reliable and adequate contraceptive methods (oral contraception or iud); * a full study-specific informed consent must be obtained in writing for all subjects exclusion criteria: * multiple daily injections of nph insulin or soluble rapid insulin or continuous subcutaneous insulin infusion (csii) therapy * mental conditions, depression, or high anxiety rendering the subject unable to understand the nature, scope, and possible consequences of the study * eating disorders * pregnancy / lactation. * any clinically significant major organ system disease such as relevant cardiovascular, gastrointestinal, hepatic, neurological, endocrine, haematological or other major systemic diseases or infective diseases making implementation of the protocol or interpretation of the study results difficult * any disease or condition including abuse of illicit drugs, prescription medicines or alcohol that in the opinion of the investigator may interfere with the completion of the study * subjects unlikely to comply with protocol, e.g., uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study procedures.

Keywords: diabetes telemedicine self monitoring blood glucose
effectiveness of acupuncture in post-mastectomy patients with tissue expanders

Conditions: Breast Cancer

Summary: the primary purpose of this study is to evaluate changes in shoulder tightness, chest tightness, and general pain related to post-mastectomy reconstructive surgery with tissue expansion in women who are randomized to receive acupuncture treatment immediately after surgery (twice a week for 6 weeks) compared to those who are randomized to no acupuncture treatment for 6 weeks, but offered acupuncture at the end of the 6 week study period.


Eligibility criteria:
inclusion criteria: * women who are newly diagnosed with breast cancer, enrolled in the the breast cancer database of nyu cancer center (bcd) and who are having breast cancer surgery involving a mastectomy procedure with insertion of a tissue expander for reconstructive purposes * women who are newly diagnosed with breast cancer * women who are enrolled in the breast cancer database (bcd) * women who are having breast cancer surgery involving a mastectomy procedure with insertion of a tissue expander for reconstructive purposes exclusion criteria: * women who had neoadjuvant chemotherapy and/or radiation therapy, women who are currently on anticoagulant therapy, women who are having breast reconstruction with alloderm, women who have chronic pre-operative pain, and/or women who have had a history of previous implants or prior augmentations * women who had neoadjuvant chemotherapy and/or radiation therapy * women who are currently on anticoagulant therapy * women who are having breast reconstruction with alloderm * women who have chronic pre-operative pain * women who have had a history of previous implants or prior augmentations * women who are currently on anticoagulant therapy * women who are having breast reconstruction with alloderm * women who have chronic pre-operative pain * women who have had a history of previous implants or prior augmentations

Keywords: breast expanders
mindful eating for eating behavior individuals overweight and obesity

Conditions: Overweight and Obesity; Behavior, Eating; Feeding Patterns

Summary: this clinical trial aims to compare the effect of a nutritional intervention based on mindful eating, with standard dietary treatment, in changing the eating behavior of overweight individuals.

this clinical trial aims to compare the effect of a nutritional intervention based on mindful eating, with standard dietary treatment, in changing the eating behavior of overweight individuals. the main questions to answer are: * what is the effect of the intervention on the domains of eating behavior (emotional eating, cognitive restriction, and lack of food control - assessed by the three-factor eating questionnaire r21)? , * assess the effect of the intervention on weight and bmi. * evaluate the relationship between eating behavior domains before and after the intervention. participants in the intervention group will participate in eight sessions of a virtual therapeutic group, with up to fifteen individuals, every fifteen days, in which the theme of mindful eating and eating behavior will be worked. participants will be encouraged to undertake the following: * self-knowledge exercises between one session and another. * mindfulness meditations daily. no dietary plan will be provided. the researchers will compare the results with a control group, which will receive eight individual, fortnightly, and virtual consultations of conventional dietary treatment, which will provide: * dietary plan for weight reduction, according to current guidelines. * six food and nutrition education sessions based on the food guide for the brazilian population.

Eligibility criteria:
inclusion criteria: * body mass index greater than or equal to 25 kg/m², * internet access, * availability to participate in 8 virtual meetings. exclusion criteria: * volunteers using pharmacotherapy for obesity, * pregnancy, * lactation, * cognitive conditions, self-reported neurological or psychiatric disorders that prevent participation in the study, * decompensated thyroid disorders, and * who have undergone bariatric surgery.

Keywords: mindfulness mindful eating weight management;