Kornimate/medical-research-clean huggingface dataset:
the efficacy comparing daily and after-each-case room disinfection.

Conditions: Daily Room Disinfection; After-each-case Room Disinfection

Summary: the aim of our study was to evaluate the difference of effectiveness between daily and after-each-case room disinfection in the endoscopy unit during the covid-19 pandemic.

this study divided into 2 groups: daily room disinfection and after-each-case room disinfection. each group was also subdivided into general anesthesia or non-general anesthesia gastroscopy, and with or without ventilation consultation room. samples collection include: operation unit air (six-stage sieve percussion air sampler for sampling, airflow rate 28.3l/min, sampling time 4 min); workstation's mouse (wiping sterile cotton for sampling); endoscopist's gown, control panel buttons, and patient's bed headboard (contact plate for sampling).

Eligibility criteria:
inclusion criteria: * all the cases received gastroscopy. exclusion criteria: * high-risk personal through contact history, symptoms, body temperature, covid-19 virus nucleic acid testing and chest computed tomography (ct) scan.
trial of collaborative depression care management for hiv patients

Conditions: Depression; HIV

Summary: this project will integrate a depression treatment and brief medication adherence counseling intervention into clinical care at three hiv clinics and will use a randomized controlled trial to assess whether, relative to usual care, the intervention leads to improved hiv medication adherence. the depression treatment intervention uses a model known as measurement-based care which equips depression care managers with systematic measurement tools, a decision algorithm, and psychiatric backup and trains them to provide decision support to hiv clinicians to implement, monitor, and adjust antidepressant therapy.

our goal in this project is to conduct a randomized controlled trial of an evidence-based depression treatment intervention known as measurement-based care (mbc), combined with brief motivational interviewing (mi) adherence counseling, in depressed people living with hiv/aids to assess its impact on art adherence and clinical outcomes. mbc employs depression care managers with expertise in depression management to screen for depression and help non-psychiatric physicians implement guideline-concordant, algorithm-driven antidepressant treatment. the depression care manager use standardized metrics (depressive symptoms, side effects) and an algorithm to monitor treatment response and recommend changes. weekly supervision from a psychiatrist ensures quality care. biweekly contact between patients and the depression care manager will include brief mi adherence counseling. we will recruit 390 people living with hiv/aids on antiretroviral therapy (art) with confirmed depression, and will conduct a randomized trial of the mbc intervention versus enhanced usual care. our aims are: (1) to test whether mbc improves art adherence and hiv clinical outcomes, (2) to assess the cost-effectiveness of mbc, and (3) to collect process measures concerning mbc implementation to inform replication at other sites. since the depression care manager role can be effectively filled by a behavioral health provider or nurse given appropriate training and supervision and the intervention has limited time requirements, this model is potentially replicable to a wide range of resource-constrained hiv treatment settings.

Eligibility criteria:
inclusion criteria: * age 18-65 * hiv-positive * patient health questionnaire-9 (phq-9) total score \>= 10 * confirmed current major depressive episode * english-speaking exclusion criteria: * history of bipolar disorder * history of psychotic disorder * failure of adequate trials of two different antidepressants at effective doses in the current depressive episode * current substance dependence requiring inpatient hospitalization * not mentally competent * acute suicidality or other psychiatric presentation requiring immediate hospitalization

Keywords: depression hiv adherence collaborative care measurement-based care
focused assessed echocardiography to predict fluid responsiveness

Conditions: Hypovolemia; Surgery; Hypotension

Summary: the aims of the study are: 1. to evaluate the feasibility of echocardiography monitoring in postoperative unit; 2. to assess diagnostic value of different focussed echocardiography parameters to define fluid responsiveness for non-cardiac hypotensive spontaneously breathing patients after major abdominal surgery.

as there are different strategies of perioperative fluid management discussion which is the choice liberal or restrictive one occurs? individualized infusion therapy should be the goal. the investigators hypothesize extended hemodynamic monitoring based on focused transthoracic echocardiography enable to differentiate the cause of hypotension more carefully and fluid overload will be avoided after major abdominal surgery. the goals of the study are: * to conduct one group of hypotensive patients after major abdominal surgery. to divide this group into responders and nonresponders after fluid challenge. * to evaluate the feasibility of echocardiography monitoring in postoperative unit (having in mind such restrains as supine position, postoperative pain, bandages etc.) * to compare the evaluation of fluid responsiveness by clinical signs and focused assessed echocardiography data. * to identify the best focused echocardiography parameters for prognosis of fluid responsiveness. * to determine if extended hemodynamic monitoring changes postoperative fluid management.

Eligibility criteria:
inclusion criteria: * age more than 18 years old. * patients who sign an agreement form to participate in the study. * patients undergoing major abdominal surgery. * hypotension exclusion criteria: * younger than 18 years old. * known pregnancy. * unconscious patients or those who do not agree to participate in the study. * urgent surgery. * normal arterial blood pressure.

Keywords: fluid responsiveness focused echocardiography major surgery
study on folfox6 as first-line therapy to treat recurrent or metastatic esophageal cancer

Conditions: Esophageal Squamous Cell Carcinoma

Summary: the aim of this study is to explore whether folfox6 as treatment could improve the time to progression (ttp) and overall survival (os) of the patient with recurrent or metastatic esophagus.

explore whether folfox6 as treatment could improve the ttp and os of the patient with recurrent or metastatic esophagus

Eligibility criteria:
inclusion criteria: 1. histologically proven primary thoracic esophageal squamous cell carcinoma 2. without chemotherapy or neo-adjuvant chemotherapy in 6 weeks ,radiotherapy has end at least 1 month,target lesion was not in an irradiated area. 3. presence of at least one index lesion measurable by ct scan or mri 4. 18\~75 years 5. kps ≥ 70 6. life expectancy of ≥ 3 months 7. anc ≥ 2×109/l，plt ≥ 100×109/l，hb ≥ 90g/l 8. cr ≤ 1.0×unl 9. tb ≤ 1.25×unl； alt/ast ≤ 2.5×unl，the patient with liver metastasis alt/ast ≤ 5.0×unl；akp ≤ 2.5×unl 10. signed written informed consent exclusion criteria: 1. previous exposure to oxa therapy in one year 2. diameter of tumor abdominal ≥ 10cm, total volumes of liver lesions ≥ 50%,lung metastasis ≥ 25% total lung 3. chronic diarrhea,enteritis,intestine obstruction which are not under control 4. psychiatric or addictive disorders that preclude obtaining informed consent or adherence to protocol. 5. peripheral neuropathy ≥ ctcae 1 6. other serious disease 7. previous or concomitant malignancies except non-melanoma skin cancer, carcinoma in situ of the cervix, and invasive carcinoma of the colon, thyroid, cervix, or endometrium treated five years prior to study entry. 8. use other antitumor therapy 9. breast-feeding or pregnant women, no effective contraception if risk of conception exists
different localization techniques for non-palpable breast lesions comparison: a retrospective and multicentric clinical study

Conditions: Breast Cancer

Summary: breast conservative surgery (bcs) is nowadays the standard of care for patients affected by early breast lesions. screening programmes led to an increase of non-palpable breast lesion detection rates. these patients are often eligible for bcs and an accurate preoperative localization technique for the detection of the lesion is required to guarantee a safe surgical excision. the primary goal of bcs is to obtain a complete resection of the tumor with disease-free surgical margins. the presence of tumor on surgical margins on postoperative histological examination of the specimen increases the risk of local recurrence and it requires a surgical re-excision. for all these reasons different techniques for localization of non-palpable breast lesions have been developed over time. since '70s the wire guided localization (wgl) technique has represented the gold standard; however it has several limitations such as wire migration or fracture and patient referred discomfort related to wire placement. over time, other techniques have been proposed, such as the radioguided occult lesion localization (roll), radioactive and magnetic seeds, carbon dye and ultrasound-guided preoperative localization. currently there are several studies of comparison between the wgl and the more modern techniques. all of these data claim the effectiveness of the new "wire-free" methodics ensuring a safe surgical resection with tumor-free margins and, in some cases, a better aesthetic result. studies of comparison between the modern techniques are limited. there is no scientific evidence of the superiority of a technique over the other. a multicentric italian survey demonstrated that the most used localization techniques nowadays are the wgl, roll, the magnetic seed and the carbon dye. the aim of this retrospective study is to compare these techniques to assess their efficacy in the localization of non-palpable breast lesions.


Eligibility criteria:
inclusion criteria: * female sex; * patients who underwent breast conservative surgery for non-palpable occult breast lesions; * intraoperative localization of breast lesion with wgl, roll, magnetic seed, carbon dye; * preoperative diagnosis on histology or cytology of borderline lesion (b3 or c3) or malignant lesion (b4-b5 or c4-c5). exclusion criteria: * diagnosis of benign breast lesion, both on preoperative needle breast biopsy (b2) or on fine needle breast aspiration (c2); * clinically palpable breast lesion; * localization of a non-palpable lesion through two or more different techniques; * breast tumor localization with clip in patients who underwent neoadjuvant chemotherapy.
absorbable suture versus nonabsorbable suture intradermal for the skin transverse section in cesarean

Conditions: Cesarean Section; Sutures

Summary: context: cesarean section is the most common surgery in women, both in developed and underdeveloped countries. however results are conflicting report in which material for intradermal suturing get better aesthetic result. objective: to compare the aesthetic appearance of two suture materials, polyglecaprone 25 and polyamide (nylon) with intradermal sutures for skin closure in women undergoing cesarean section first. methods: this is a clinical, prospective and randomized study which was conducted in the department of gynecology and obstetrics of a tertiary institute, hospital das clinicas samuel libânio, in pousoalegre, estate of minas gerais. sixty women undergoing cesarean section were first included and randomized into two groups: group i (n = 30) polyamide and group ii (n = 30) polyglecaprone 25. hypertrophy, color and width of the wound were evaluated, receiving a score, according to trimbos table, six months after surgery. later the results were compared to non-parametric statistical tests


Eligibility criteria:
inclusion criteria: * patients who underwent cesarean section * no restriction of ethnicity, education or social class exclusion criteria: * scarring pfannenstiel prior * diabetic patients using drugs; * patients with collagen diseases * patients with pre operative tests to indicate any systemic sign of infection or site, not previously treated until the time of surgery. * patients who withdrew informed consent * patients who did not attend the pre scheduled dates for the controls after surgery .

Keywords: wound closure thechnical wound healing
teen success project

Conditions: Substance Abuse

Summary: the purpose of this study is to examine the effectiveness of juvenile probation officers (jpos) delivering contingency management (cm) to teens on their caseload who have problems with drug use. cm has already been shown to be effective at helping teens with drug problems but cm has never been delivered by jpos. this study will test how well it works to have jpos deliver cm during their regular meetings with teens.

the overarching purpose of this study is to increase justice-involved youths' access to an evidence-based practice for substance abuse, specifically contingency management (cm). this randomized controlled trial will examine the effectiveness of using juvenile probation officers (jpos) to deliver cm to youth (aged 12-17 years) on their caseloads. cm is an evidence-based practice for substance abuse. the investigators posit that jpos are in an ideal position to deliver an evidence-based practice such as cm to youth because of their intensive involvement and frequent contact with the youth offenders under their supervision. the study randomizes 36 jpos to 2 conditions: cm versus control (usual jpo services), and then randomizes 504 drug-abusing adolescent probationers across those 2 conditions. the research team will work with jpos employed by the department of youth services (dys) in various counties in oregon. jpos will participate in focus groups and research interviews and will submit monthly audio-tapes of sessions with participating youth. jpos randomized to the cm condition will receive training in how to deliver cm. as stated, participating youth will also be randomized to cm or control and assigned to a jpo in the same condition. for those in the cm group, the delivery of cm will be added to their regular meetings with their jpo. research data will be collected from families via audio-taped interviews and questionnaires from youth and one caretaker. urine samples for drug testing will also be collected from youth. lastly, arrest records will be collected on youth for the 18 months pre- and post-entry into the study. the study involves 2 types of participants: youth (n=504) and juvenile probation officers (n=36), for a total of 540 anticipated participants.

Eligibility criteria:
there are 2 types of participants in this study: youth and juvenile probation officers. inclusion criteria for youth: * newly opened probation case (can have previous cases) * 12-17 years old * diagnostic and statistical manual-5 (dsm-5) substance use disorder exclusion criteria for youth: * pervasive developmental disorder * active psychotic disorder * severe/profound mental retardation inclusion criteria for juvenile probation officers: * employed as a juvenile probation officer with the department of youth services in a participating county in oregon * serving clients aged 12-17 years old with a substance abuse problem exclusion criteria for juvenile probation officers: * not employed as a juvenile probation officer with the department of youth services in a participating county in oregon * not serving clients aged 12-17 years old with a substance abuse problem
clinical evaluation of the steroid-eluting sinexus intranasal splint when used following functional endoscopic sinus surgery (fess) in patients with chronic sinusitis

Conditions: Chronic Sinusitis

Summary: this study allows continued access to the sinexus intranasal splint while a marketing application is being prepared. this study will generate additional performance, reimbursement and safety data for the steroid-eluting sinexus intranasal splint when used following functional endoscopic sinus surgery (fess) in patients with chronic sinusitis (cs).


Eligibility criteria:
inclusion criteria: * patient is 18 years of age or older * patient has a diagnosis of chronic sinusitis * patient has a clinical indication for and has consented to fess * patient ct scan confirms cs diagnosis within 6 months of procedure * ct sacn confirms presence of disease in ethmoid sinus(es) * planned fess includes unilateral or bilateral total ethmoidectomy exclusion criteria: * immune deficiency (igg subclass deficiency or iga deficiency) * oral-steroid dependent copd, asthma or other condition * clinical evidence of acute bacterial sinusitis * history or diagnosis of glaucoma or ocular hypertension * clinical evidence or suspicion of invasive fungal sinusitis * evidence of disease or condition expected to compromise survival or ability to complete follow-up * known history of allergy or intolerance to corticosteroids * history of insulin dependent diabetes

Keywords: patients diagnosed with chronic sinusitis undergoing functional endoscopic surgery (fess)
safety and pharmacology study of snx-5422 mesylate in subjects with refractory solid tumor malignancies

Conditions: Cancer

Summary: hsp90 is a chemical in the body that is involved in promotion of cancer. snx-5422 is an experimental drug that blocks hsp90. it is being evaluated for safety and efficacy in patients with cancer.


Eligibility criteria:
inclusion criteria: * \>18 years old * histologically confirmed solid tumor malignancy * refractory to available therapy or for which no therapy is available * adequate organ function exclusion criteria: * cns malignancy * significant gi disease * at risk for prolonged qt interval

Keywords: solid tumor malignancy; hsp90
cardiovascular safety after continuous ketamine infusion

Conditions: Pain; Ketamine Adverse Reaction; Postoperative Pain

Summary: observational study that evaluate the cardiovascular and neuropsychiatric side effects of ketamine analgesic infusions for acute pain

severe acute pain and opioid tolerance is an important symptom in patients after surgery. ketamine in analgesic infusion has been described to decrease acute pain, in patients with opioid tolerance. ketamine use has been associated with side effects, which are doses dependant. those side effects are mainly cardiovascular: hypertension, tachycardia, and neuropsychiatric: delirium, hallucinations,nightmares that potentially compromise recovery of patients. objective: to determine retrospectively in data bases the frequency of tachycardia, hypertension, delirium, hallucinations and nightmares, in adult patients that received ketamine infusions before and after administration of this drug in the first 48 hours to treat acute and postoperative pain

Eligibility criteria:
inclusion criteria: * patients older than 18 years old * acute and postoperative pain * ketamine infusion at 0.15 mg/kg/h or below exclusion criteria: * cognitive disfunction psychiatric illness * acute cardiovascular disease * anemia with hb less than 7 g/dl * decompensated hyperthyroidism * low cardiac output * incomplete medical history
risk taking behaviour in msm and the denial of sexually transmitted diseases and hiv

Conditions: MSM; HIV Infections; Risky Behaviors

Summary: four focus groups , each of 10-15 males, ages 20-50 years old, msm will be conducted by a medical sociologist. two groups will be hiv negative participants and two groups of hiv positive msm. every group will meet for two hours. the focus group will be recorded and the collected data will be processed further for evaluation and extraction of the relevant information. the volunteers will sign an inform consent prior to entrance to the study.

the questions that will be discussed during the focus groups: the first sexual contact with a male, what is risk, risk taking behavior, control over your daily life, self esteem and evaluation, risk denial.

Eligibility criteria:
inclusion criteria: * age 20-50 * msm, willing to participate * agree to sign an inform consent exclusion criteria: * no exclusion criteria

Keywords: msm focus group hiv risk-taking risk-denial signature on inform consent, willing to participate, msm either hiv positive or negative, age 20-50 years old
pd-1 antibody and radiotherapy for recurrent cervical cancer

Conditions: Immune Checkpoint Inhibitors; Anti-programmed Death-1 Antibody; Radiotherapy; Recurrent Cervical Carcinoma; Metastatic Cervical Carcinoma; Persistent Advanced Cervical Carcinoma; Objective Remission Rate; Progression-free Survival; Overall Survival; Severe Adverse Events

Summary: this study is to investigate retrospectively the effects of combination of immune checkpoint inhibitors anti-programmed death-1 antibody (pd-1 antibody) and radiotherapy for recurrent, metastatic and persistent advanced cervical carcinomas. patients may or may not accept pd-1 antibody as maintenance therapy. patients are followed up and the survival outcomes are evaluated. the primary endpoint are objective remission rate. the secondary endpoints are progression-free survival, overall survival and severe adverse events.


Eligibility criteria:
inclusion criteria: * aged 18 years or older * confirmed of recurrent, metastatic, and persistent advanced cervical cancer * confirmed of subtypes of cervical squamous carcinoma, adenocarcinoma and adenosquamous carcinoma * accepting radiotherapy with concurrent anti pd-1 therapy * with detailed follow-up outcomes exclusion criteria: - not meeting all of the inclusion criteria
optimal surgical approach for early-stage breast cancer in chinese patients aged ≤ 40 years: a cohort study

Conditions: Breast Cancer

Summary: the optimal surgical treatment option (bcs+rt versus mast) for young patients with early-stage breast cancer remains debated. the present study aims to explore trends in surgical management and compare survival outcomes between bcs+rt and mast in young patients with early-stage breast cancer, ultimately providing optimal treatment strategies for asian populations.

this study is a unique addition to the current research on young women with early-stage breast cancer, aiming to compare the survival outcomes between bcs+rt and mast, providing valuable insights into their effectiveness for this group of patients. this study enrolled patients at west china hospital, sichuan university. kaplan-meier analyses with the log-rank test were applied to compare the locoregional recurrence-free survival (lrfs), distant metastasis-free survival (dmfs), breast cancer-specific survival (bcss), and overall survival (os). cox multivariate hazard regression was employed to assess hazard ratios (hrs) between the two groups for survival outcomes.

Eligibility criteria:
inclusion criteria: * patients aged 18-40 years. * pathological diagnosis of invasive breast cancer. * undergoing breast-conserving surgery (bcs) with radiotherapy (rt) or mastectomy (mast). * availability of detailed clinical information, including: tumor (t) stage. node (n) stage. clinical stage. hormone receptor status. endocrine therapy details. targeted therapy details. exclusion criteria: * male patients. * patients with distant metastatic disease. * patients with bilateral breast cancer. * patients not undergoing surgery. * follow-up time of less than 1 month.

Keywords: breast cancer breast-conserving surgery radiotherapy mastectomy