Kornimate/medical-research-clean huggingface dataset:
efficacy of an online program for the treatment of mild and moderate depression

Conditions: Depression

Summary: ifighdepression is an online self-help programme based on cognitive-behavioral therapy that could be useful for the treatment of mild to moderate depression

major depression (md) is a disease with a great impact on people´s functioning and is the second leading cause of disability worldwide. it is a condition with a high prevalence, about 10% of men and 20% of women in the population will be diagnosed md throughout their lives, and has an effect on high economic costs to health services. while there are many effective therapeutic options for the treatment of depression, many people with depressive episodes do not receive an appropriate treatment or, in fact, do not receive any treatment at all. the social stigma, difficulties to access mental health services, to integrate therapy sessions into working life, or problems to pay for treatment are some of the main barriers to receive adequate treatment. on-line interventions are easily accessible and low cost, and different studies suggest that these interventions have significant and lasting improvements in different mental disorders. these studies indicate that this type of treatment would be indicated for disorders that, as the case of md, have a high prevalence and relatively low help-seeking for treatment. ifighdepression is an online self-help programme for mild to moderate depression that has been developed in the context of the european project preventing depression and improving awareness through networking in the european union (predi-nu) which is managed by the european alliance against depression (eaad). it involves the most complete integration of the cognitive-behavioral online programs available to date, which is a format of intervention that has been proven effective in reducing depressive symptoms in several randomized controlled trials. ifightdepression is currently in pilot phase in 7 european union countries, including spain. the purpose of this project is to study the therapeutic effect of the ifightdepression online programme in patients with mild to moderate depression

Eligibility criteria:
inclusion criteria: * diagnosis of major depressive disorder according to diagnostic and statistical manual (dsm-iv-tr) criteria. * clinical severity between mild and moderate (according to icg severity scale). * a minimum of reading comprehension and knowledge of internet browsing. * availability to access internet during the 7 weeks of the intervention. * informed written consent provided. exclusion criteria: * suicidal ideation (assessed by the hdrs and clinical interview). * presence of delusional ideas or hallucinations, consistent or not with the mood. * other concomitant psychiatric pathologies of the axis i or axis ii according to diagnostic and statistical manual (dsm-iv-tr) at the time of entry to the study. * to be currently enrolled in a structured programme/treatment of psychotherapy.

Keywords: depression cognitive-behavior intervention
a clinical investigation to follow the progress of exuding chronic wounds using mepilex® up as the primary dressing.

Conditions: Wounds; Wound of Skin; Wound Leg; Wound; Foot; Diabetic Foot Ulcer; Venous Leg Ulcer

Summary: the goal of this clinical trial is to follow the progress of wounds in those with venous leg ulcers and diabetic foot ulcers while using an absorbent dressing called mepilex up. the main objective is to follow the progress of these wounds over time from initial visit to each follow-up visit. participants will be asked to wear mepilex up dressing for up to 6 weeks of treatment or until healed, changed at every one-week interval.

this investigation is designed as a prospective, open, multi-center, interventional, non-comparative investigation with the aim to follow exuding chronic wound progression for 6 weeks according to local standard of care. wound progress is a summary endpoint of the total effect of treatment using mepilex up as the absorbent dressing and includes the changes in an objectively measured wound area and subjectively evaluated wound condition. two indications will be included: venous leg ulcers (vlu) and diabetic foot ulcers (dfu). a total of n=68 participants, approximately 34 per indication, will be recruited at up to 8 centers in the us. there will be a total of seven (7) visits to the investigation site for participants during the treatment period: baseline, followed by weekly visits up to six (6) weeks post baseline. during visits, evaluations will be performed to assess wound progression and status, wound dressing properties, as well as subject pain, comfort, and quality of life. safety will be assessed at all visits. one target wound per participant will be included in this investigation.

Eligibility criteria:
inclusion criteria: * signed consent to participate (including consent for digital imaging) * adult aged ≥18 years * diagnosed with a chronic, exuding vlu or dfu * exudate amount moderate to large * wound size from 3 cm2 to 30 cm2 for vlu and ≥1 cm2 for dfu, as determined by the clinician * for vlu: abpi (within 3 months) \> 0.7. if abpi \> 1.4, then big toe pressure \> 60 mmhg is required or an alternative measurement verifying normal distal arterial flow * for vlu: willing to be compliant with compression therapy exclusion criteria: * infected ulcer according to the judgment of the investigator defined as any wound condition requiring the prescription or continuation of systemic antibiotic therapy at enrollment * circumferential wound * known allergy/hypersensitivity to the materials of the dressing * patients participating in the diplo nbf study * use of wound fillers

Keywords: diabetic foot ulcer venous leg ulcer
acute effects of the two alternative sweeteners d-allulose and erythritol on metabolism

Conditions: Physiological Satiation Mechanisms

Summary: the aim of this project is to investigate the effect of intragastric (ig) d-allulose on metabolic parameters in general and to investigate the effect of sweet taste receptor blockade on gi hormone responses, glycemic control, gastric emptying (ge) rates and appetite-related sensations to ig administration of erythritol and d-allulose.

erythritol (natural non-caloric sweetener) could be an ideal candidate substitute for sugar as it may reduce caloric intake without compensatory overeating or earlier return of hunger. moreover, it may serve as a physiological tool to disentangle the effects of gastrointestinal (gi) sweet taste receptor stimulation, (an)orexigenic hormone secretion, and glucose metabolism/caloric content on food intake regulation in vivo in humans. however, its effects on appetite, satiation, and satiety have not been studied systematically. moreover, the mechanisms underlying erythritol-induced anorexigenic gi hormone release have not been investigated so far. d-allulose is a sugar substitute with almost zero calories and is naturally occurring in small quantities. apart from its use as sugar replacement, d-allulose seems to favorably affect glycemic control and metabolism as could be shown in animal trials and in a few human trials. however, to date the effects of d-allulose on gi hormone secretion, appetite-related sensations and glycemic control, are not or insufficiently studied in humans. the aim of this project is therefore to investigate the effect of intragastric (ig) d-allulose on metabolic parameters in general and to investigate the effect of sweet taste receptor blockade on gi hormone responses, glycemic control, gastric emptying (ge) rates and appetite-related sensations to ig administration of erythritol and d-allulose.

Eligibility criteria:
inclusion criteria: * healthy normal weight subjects with a body-mass index of 19.0-24.9 * normal eating habits (no diets; no dietary changes) * age 18-55 years * stable body weight for at least three months * informed consent as documented by signature (appendix informed consent form) exclusion criteria: * pre-existing consumption of erythritol or d-allulose on a regular basis (usage of erythritol or d-allulose as sugar replacement; in contrast, erythritol-containing toothpaste is allowed) * substance abuse * regular intake of medications, except anticonceptives * chronic or clinically relevant acute infections * pregnancy: although no contraindication, pregnancy might influence metabolic state. women who are pregnant or have the intention to become pregnant during the course of the study are excluded. in female participants a urine pregnancy test is carried out upon screening. * participation in another study with investigational drug within the 30 days preceding and during the present study.
effectiveness of tonsil fossa closure in pain relief after tonsillectomy in children

Conditions: Tonsillitis

Summary: objective: postoperative pain is the main complaint in children undergoing tonsillectomy. an inexpensive method and with few evidence in the literature on effectiveness in reducing pain is the closure of the tonsillar fossa by suture with absorbable sutures. the investigators will compare the pain after tonsillectomy between closure or not the tonsil fossa. study design: prospective, randomized, double blind, and controlled. method: two hundred otolaryngologic outpatients with indication of bilateral tonsillectomy for repeated tonsillitis, tonsillar hypertrophy or sleep apnea between 5 and 12 years old will be enrolled from november 2015 to july 2016. the procedure will be performed by a single surgeon and similar postoperative medications will be prescribed. there will be two techniques: closure or not of the tonsillar fossa with catgut points. a questionnaire containing a faces pain scale - filled 1 and 7 days after surgery- and other data - difficulty of detachment of the palatine tonsils, hemostasis technique, surgical complications, healing characteristics, day of total improvement of the pain, day of beginning of normal food intake, presence of postoperative bleeding, complications and observations raised by the patient - will be applied.


Eligibility criteria:
inclusion criteria: * no cognitive-intellectual changes; * capacity to respond the questionnaire; * able to help in the study exclusion criteria: * conducting invasive procedure for less than two months; * history of any infection during last month; * continuous use of any medication; * postoperative fever; * non-standard medication prescribed for the postoperative time

Keywords: pain tonsillectomy tonsillar fossa suture tonsil fossa closure
il-35+breg/il-35 effect on t cell immune in patients with chb

Conditions: Chronic Hepatitis b

Summary: the investigators observed the level of il-35 secreting b regulatory (il-35+bregs) cells in peripheral blood cells in patients with chronic hepatitis b, and analysed the relationship between the il-35+bregs level and disease stage, and th1 and th2 cells level.

regulatory b cells (bregs) are involved in the immune tolerance process through multiple pathways and bregs are involved in the process of chronic hbv infection. here the investigators intended to investigate the regulating role and the mechanism of cd19+ il-35+ cells on host t cell immune during chronic hbv infection by using in vitro cell sorting, b cell differentiation induction, transwell cell co-culture system and other methods.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic hepatitis b virus infection * 17\<age\<70 * can read, understand and sign patients informed consent exclusion criteria: * co-infection with hcv,hiv,hdv etc. * have malignancy * have uncontrollable extra-hepatic disease

Keywords: chronic hepatitis b regulating b cells t help 17 cells interleukin 35
baseline blood indices and prolonged length of hospital stay

Conditions: Hospitalism; COVID-19 Pneumonia; Diabetes Mellitus, Type 2

Summary: during a pandemic, length of hospital stay (los) is critical to managing high patient volumes and preserves access to care related to non-covid-19 for maintaining the healthcare system. moreover, identiﬁcation of prolonged hospital stay may allow physicians to reevaluate critical patients, focused delivery of specific interventions, and improve the efficiency of hospital care. furthermore, in previous recent studies, attention has been paid to patients with diabetes and covid-19 infection may require a prolonged los. however, there is little evidence on prognostic factors associated with an extension of hospitalization in mild or moderate illness due to covid-19 infection. therefore, it is crucial to determine the most vulnerable patients with diabetes mellitus even if they have a non-severe covid-19 infection during the pandemic. we hypothesize that the clinically relevant inflammatory parameters may have an impact on los in older adults with diabetes and non-severe covid-19 infection. therefore, we aim to investigate whether baseline inflammatory parameters on admission hospitals as possible predictors of prolonged los in older adults with diabetes and non-severe covid-19 infection during the pandemic.


Eligibility criteria:
inclusion criteria: * we included all hospitalized covid-19 patients with diabetes mellitus according to the any established diagnosis prior to admission or american diabetes association guidelines for diagnostic criteria exclusion criteria: * the patients with severe covid-19 infection, secondary diabetes or type 1 diabetes mellitus were excluded.

Keywords: length of hospital stay covid-19 pneumonia diabetes mellitus
thermal energy in the treatment of cervicogenic dizziness

Conditions: Dizziness; Cervical Pain

Summary: cervical pain contributes to postural deviations and imbalance. nanotechnology may be used for the treatment of neck pain by fixing to the skin small rounds silicone patches containing double spiral carbon nanotubes arranged in the form of a coil (helical), which would then relieve dizziness caused by muscular contraction.

the selected patients should have neck pain arising from muscle contraction with loss of balance or instability lasting more than 90 days and normal electrooculography. treatment consisted of placing 10 helical patches, placebo or active, distributed as follows: two in the upper cervical area, two in the lower cervical area (near the 5th and 6th vertebrae), two in the upper trapezius muscle area (between neck and shoulder), and four in the tender point area (as reported by the patient). using a visual analogue scale (vas) and specific questionnaires, the investigators will match pain, muscle tension and dizziness scores from day 1 to those from day 15 and day 30.

Eligibility criteria:
inclusion criteria: * cervicogenic dizziness diagnosis * normal otoneurological examination * signed the informed consent form * neck without other radiological changes, which are not solely attributable to aging (osteophytosis, rectification, disc space reduction). exclusion criteria: * active vestibular disease * traumatic neck injury * neurological * rheumatic or orthopedic diseases not attributable to aging (fractures, tumors) and/or that have surgical indication * somatoform diseases; cognitive limitations.

Keywords: thermal vertigo
effect of long biliopancreatic limb rygb on weight loss and comorbidities

Conditions: Morbid Obesity

Summary: morbid obesity is an increasing medical problem in the western countries. it's related to comorbidities as diabetes mellitus, hypertension, osas, arthrosis and hypercholesterolemia. the roux-en-y gastric bypass (rygb) is an effective surgical therapy for morbidly obese patients. a part of these patients will have disappointing results, and have weight regain on the long term. some studies show more weight reduction by increasing the biliopancreatic limb in patients with morbid obesity. the objective of this study is to investigate the effect of variations in the length of biliopancreatic limb on weight reduction in morbidly obese patients undergoing rygb-surgery. we hypothesize that longer biliopancreatic limb results in more weight reduction. the study design is a prospective, randomized control trial. the patients will be randomized in 2 groups: a standard rygb (short biliopancreatic limb) and long biliopancreatic limb rygb.


Eligibility criteria:
inclusion criteria: patient eligible for bariatric surgery according fried guidelines primary gastric bypass * bmi 35 - 40 with a comorbidity * or bmi \> 40 redo- operation * medical history: gastric sleeve/ mason / gastric band * all bmi levels exclusion criteria: * exclusion criteria for bariatric surgery (fried guidelines) * patients with language problems that interveins to follow medical advises * genetic diseases that intervens to follow medical advises * chronic bowel diseases * nephrologic (mdrd \<30) of liver diseases (ast/alt more than twice the norm) * pregnancy

Keywords: bariatric surgery roux-en-y gastric bypass
acupuncture for diabetic gastroparalysis: a randomized controlled trial

Conditions: Gastroparesis; Diabetes Complications

Summary: the purpose of this study is to determine whether the different combination of acupoints have different effect on diabetic gastroparalysis.


Eligibility criteria:
inclusion criteria: * individuals who meet the diagnostic criteria of diabetes gastric paralysis. * individuals between the ages of 18 and 60 years. * individuals who meet blood glucose control standards: fasting plasma glucose (fpg) ≤7. 8mmol/l; 2 hours plasma glucose (2hpg)≤13.6mmol/l. * individuals who suffered for more than 3 years. * individuals who treated with diet control or exercise or using hypoglycemic drug (except for α-glucosidase inhibitor) on the basis of diet or exercise therapy and the dose stability must be last at least 3 months. * individuals who receive no other treatments in the first 3 months. * women who is at the age of childbearing age and take contraceptive measures. * individuals who voluntarily agree with a study protocol and sign a written informed consent. exclusion criteria: * individuals who have reflux esophagitis; * individuals who have gastroparesis after surgery; * individuals who have acute complications with ketoacidosis and nonketotic hyperosmolar coma; * individuals who have acute cardiovascular and cerebrovascular diseases or severe trauma or surgery, severe infection. or who are pregnant or breastfeeding; * individuals who have a history disease of myocardial infarction, acute coronary syndrome or coronary revascularization; * individuals who have serious hepatobiliary disease, or ast and/or alt 2 times greater than the upper limit of normal patients; * individuals with kidney damage, and serum creatinine exceeds 140umol/l; * individuals who have obvious blood system diseases (any one of which can not be caught in line: hb: male\<110g/l, women\<100g/l,wbc\<3.5×109/l,plt\<80×109/l). * individuals who have a problem of blood press:sbp≥180mmhg,dpb≥100mmhg; * individuals who have cancer or other serious progressive wasting disease, and easy to infection and bleeding; * individuals who have peptic ulcer or other organic disease confirmed by esophagogastroduodenoscopy; * individuals unwilling to meet the testing and exacerbations,or have serious complications in the test; * individuals who have taking α-glucosidase inhibitor drug in the past four weeks.
safety, effectiveness and manipulability evaluation of a domestic pd machine

Conditions: Kidney Failure,Chronic

Summary: this study is a randomized, multi-center，crossover study of a domestic fm peritoneal dialysis machine and baxter homechoice.it aims to verify safety, effectiveness and manipulability of a domestic peritoneal dialysis machine.

our study is a randomized, multi-center，crossover study. it compares a domestic fm peritoneal dialysis machine with baxter homechoice.it aims to verify safety, effectiveness and manipulability of a domestic peritoneal dialysis machine.

Eligibility criteria:
inclusion criteria: age ≥18, male or female dialysis duration:≥30 days sign the written informed consent exclusion criteria: hemodialysis exit site infection or tunnel infection peritonitis ≤30 days before screening catheter mechanical failure anti-hiv positive allergic to components of dialysate comorbidity:active, residual malignant tumor, or systemic infection, liver cirrhosis, severe congestive heart failure,hypertension poor compliance pregnant or lactating, women of childbearing age do not agree to use effective contraceptive measures during the trial has a history of alcoholism and drug abuse (defined as illegal drugs) any circumstances when patients are believed unsuitable for this trial

Keywords: automated pd effectiveness safety manipulability
the effect of functional electrical stimulation cycling ergometry in addition to robotic rehabilitation

Conditions: Spinal Cord Injuries

Summary: spinal cord injury (sci) is a devastating neurological condition resulting from either traumatic or non-traumatic causes, leading to loss of motor, sensory, and autonomic functions in individuals. statistics indicate that more than 75% of individuals with incomplete sci regain some degree of ambulatory function. authors' aim in this study is to investigate the effect of adding functional electrical stimulation (fes) bicycle ergometry to robotic rehabilitation on lower extremity functional recovery and ambulation in patients with chronic incomplete sci.

spinal cord injury (sci) is a devastating neurological condition resulting from either traumatic or non-traumatic causes, leading to loss of motor, sensory, and autonomic functions in individuals. statistics indicate that more than 75% of individuals with incomplete sci regain some degree of ambulatory function. to the authors' knowledge, no other study has investigated the effect of adding fes bicycle ergometry to robotic rehabilitation on lower extremity functional recovery and ambulation in patients with chronic incomplete sci. authors' hypothesis is that the group receiving fes bicycle ergometry in addition to robotic rehabilitation will achieve better functional recovery and ambulation compared to the group receiving only robotic rehabilitation. in this context, authors' aim in this study is to investigate the effect of adding functional electrical stimulation bicycle ergometry to robotic rehabilitation on lower extremity functional recovery and ambulation in patients with chronic incomplete sci.

Eligibility criteria:
inclusion criteria: 1. motor incomplete spinal cord injury (asia c and d). 2. at least 6 months post spinal cord injury. 3. age between 18 and 65 years. 4. ability to walk at least 10 meters independently or with assistive devices such as a cane or crutches. 5. signed informed consent form indicating willingness to participate in the study. exclusion criteria: 1. severe spasticity or joint contracture in the lower extremities that impedes movement. 2. presence of metallic implants in the lower extremities. 3. stage 2 or higher pressure ulcers on the sacral or coccygeal regions. 4. co-existing peripheral neuropathy. 5. permanent urinary catheter use. 6. contraindications for walking exercises (e.g., cognitive impairment preventing exercise compliance, unstable epilepsy or unexplained convulsions, unstable acute cardiac arrhythmia or heart failure, presence of a cardiac pacemaker). 7. psychiatric disorders or cognitive problems that prevent completing questionnaires and assessment scales. 8. presence of other neurological or muscular diseases.

Keywords: spinal cord injury functional electrical stimulation bicycle ergometry robotic rehabilitation