Kornimate/medical-research-clean huggingface dataset:
partner-specific hiv risk reduction intervention for drug-using adolescents

Conditions: Sexually Transmitted Diseases; Substance-Related Disorders

Summary: the purpose of this study is to develop and pilot test a partner-specific hiv risk reduction intervention for currently or recently incarcerated adolescents who report problematic substance use.

incarcerated adolescents represent a group at high risk for health consequences associated with risky sexual behaviors. condom use is more common with non-main than main sex partners and substance use in conjunction with sexual risk also appears to vary by partner type. the research team will conduct a small randomized trial to pilot test a partner-specific hiv risk reduction intervention for currently or recently incarcerated adolescents who report problematic substance use. participants will be randomized to a 5 session hiv risk reduction group intervention based on the information-motivation-behavioral skills model, or a 5 session healthy lifestyles psychoeducation intervention, and then reassessed 3 months after their access to the general community is reinstated. the main hypothesis is that participants in the hiv risk reduction intervention condition will have lower levels of sex-related hiv risk behavior and of substance use in conjunction with sexual risk, relative to those in a healthy lifestyles psychoeducation intervention.

Eligibility criteria:
inclusion criteria: * english-speaking ability * unprotected vaginal, anal, or oral intercourse at least once in the 6 months prior to incarceration or placement * marijuana use disorders, other non-injection drug use disorders, or substance use by a sexual partner during a sexual episode in the six months prior to incarceration or placement * sentence or placement length between 2 and 12 months * must plan to remain in the area for the 6 months following their release from the facility * must be willing to provide two pieces of contact information for follow-up exclusion criteria: * signs of psychosis (assessed through clinical assessment)

Keywords: adolescent adolescent behavior health behavior sexual behavior incarceration behavioral intervention risk reduction behavior
weight loss and exercise to improve rheumatoid arthritis cardiovascular risk

Conditions: Rheumatoid Arthritis

Summary: this is a small exploratory, randomized, controlled trial. twenty-six older (ages 60-80 yr.), obese (bmi 28-40 kg/m2) persons with rheumatoid arthritis (ra) (seropositive or erosive) will be randomized to 16 weeks of a counseling health as treatment (chat) program or a supervised weight loss and exercise training (swet) program.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) 28-40 kg/m2. * must have internet access. * seropositive (positive rheumatoid factor or anti-citrullinated protein antibody) or erosions typical of ra on radiographs. exclusion criteria: * subject unwilling/unable to utilize online platforms (e.g. zoom, redcap, pattern health) for study activities. * current use of biologic agents other than those targeting tumor necrosis factor alpha. * current (within the last month) pharmacologic therapy with corticosteroids at doses greater than prednisone 5mg per day (or equivalent glucocorticoid doses). * participating in regular exercise within the past 3 months (according to 2018 us guidelines: not more than 150 minutes per week of moderate intensity exercise or 75 minutes per week of vigorous intensity exercise). * new medications within the last three months and stable doses for ≥ 1 month. * diagnosis of coronary artery disease. * diagnosis of type 2 diabetes mellitus. * other inflammatory arthropathy or myopathy, paget's disease, pigmented villonodular synovitis, joint infection, ochronosis, neuropathic arthropathy, osteochondromatosis, acromegaly, hemochromatosis, or wilson's disease. * absolute contra-indications to exercise: recent (\<6 months) acute cardiac event, unstable angina, uncontrolled dysrhythmias causing symptoms or hemodynamic compromise, symptomatic aortic stenosis, uncontrolled symptomatic heart failure, acute pulmonary embolus, acute myocarditis or pericarditis, suspected or known dissecting aneurism or acute systemic infection. * relative contra-indications to exercise: left main coronary stenosis, moderate stenotic valvular heart disease, outflow tract obstruction, high degree av block, ventricular aneurysm, uncontrolled metabolic disease (e.g. diabetes, thyrotoxicosis, myxedema), uncontrolled pulmonary disease (e.g. severe copd or pulmonary fibrosis), mental or physical impairment leading to inability to exercise adequately. * significant weight change (gain or loss of \> 10 pounds in 1 month) within the past 6 months. * unwillingness or inability to adhere to the diet structure of the study.

Keywords: ra seropositive ra erosive exercise diet nutrition cardiovascular risk
effects of 12-week exercise program on sleep quality and fear of death in geriatric individuals

Conditions: Sleep Disorder; Depressive Disorder; Death; Physical Inactivity

Summary: the aim of this study is to determine the effect of regular aerobic exercise program on tanatophobia and sleep quality in elderly individuals, and to evaluate the relationship between sleep disorder and fear of death.

the effect of regular exercise programs on fear of death in elderly individuals is unknown. the aim of this study is to determine the effect of regular aerobic exercise program on tanatophobia and sleep quality in elderly individuals, and to evaluate the relationship between sleep disorder and fear of death.

Eligibility criteria:
inclusion criteria: * individuals aged 65 and over who volunteered to participate in the study, * conscious and without communication problems, * no orthopedic injury that prevents walking * those who are physically inactive according to the international physical activity assessment questionnaire * those who have sufficient motivation to participate in the exercise program (will be evaluated by a one-on-one interview by the researchers) * being eligible to participate in an exercise program after a cardiac examination by a cardiologist (resting ecg and questioning of cardiac symptoms, further examinations such as exercise ecg test if necessary) exclusion criteria: * having a history of neuromuscular disease * serious medical condition (eg advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.) that would prevent the person from participating in exercise training. * less than 1 year life expectancy * having an orthopedic injury that prevents walking * presence of advanced sensory deficit * having visual and hearing problems * not having sufficient communication skills (mini mental test score below 24 points) * not having agreed to participate in the study * uncontrolled hypertension * not being found suitable for exercise in the examination performed by physicians and physiotherapists

Keywords: sleep disorder fear of death exercise elderly
evaluation of galcanezumab in the prevention of episodic migraine- the evolve-1 study

Conditions: Migraine

Summary: the main purpose of this study is to evaluate the efficacy of the study drug known as galcanezumab in participants with episodic migraine.


Eligibility criteria:
inclusion criteria: * have a diagnosis of episodic migraine as defined by international headache society (ihs) international classification of headache disorders (ichd)-3 beta guidelines (1.1 or 1.2) (ichd-3 2013), with a history of migraine headaches of at least 1 year prior to screening, migraine onset prior to age 50 and monthly frequency of 4-14 migraine headache days (mhd). exclusion criteria: * are currently enrolled in or have participated within the last 30 days or within 5 half-lives (whichever is longer) in a clinical trial involving an investigational product. * current use or prior exposure to galcanezumab or another cgrp antibody. * known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic proteins, or to galcanezumab. * history of persistent daily headache, cluster headache or migraine subtypes including hemiplegic (sporadic or familial) migraine, ophthalmoplegic migraine, and migraine with brainstem aura (basilar-type migraine) defined by ihs ichd-3 beta.

Keywords: prevention prophylaxis headache
comparison of duration of csf leak in post traumatic patients managed by early lumbar drain vs conservative treatment

Conditions: CSF Leakage

Summary: as limited data is available locally and internationally regarding early lumbar drain and its effect on duration of csf leak we have decided to compare it conservative treatment. by providing csf an alternative route for drainage, the fistula site will remain dry. leakage site won't be facing csf pressure, and this will promote early healing of the wound.

cerebrospinal fluid (csf)leak is caused by communication between the subarachnoid space and the air-filled spaces of the middle ear or para nasal sinuses and sometimes skin. csf leaks can be divided into two types ,traumatic and non traumatic. the traumatic csf leaks further divided into accidental and iatrogenic (post surgical procedures) 1. almost 80% of csf leaks are due to road traffic accidents, fall from heights and firearms injuries to brain and spine, 16% are iatrogenic, and 4% are non-traumatic 1,2. more than 50% of traumatic csf leaks are evident within the first 02 days, 70% within the first week, and almost all present within the first 3 months \[2,3\]. it is estimated that in patients with skull base fracture 10-30% develops csf leaks and 2% of all traumatic head injuries are associated with csf leaks \[4\].with the help of conservative treatment most of the csf leaks stop within 7-10 days 1,5. when the csf leak doesn't stop after 7-10 days, a lumbar drainage (ld) is suggested3,7. ld(lumbar drain) is a recommended treatment method for the csf leaks in skull base and spinal trauma, the indications for ld(lumbar drain ) placement are still controversial ,ld(lumbar drain) effect on early csf leakage cessation is still arguable 2,3. traumatic csf leaks duration can be reduced by early( lumbar drain) placement . at tertiary level particularly in public hospital, our study will be helpful to document the benefits of early lumbar drain (ld) in traumatic csf leakage patients and their hospital stay. this will also help to reduce the ambiguity regarding the protocol for early lumbar drain (ld) placement .

Eligibility criteria:
inclusion criteria: 1. age between 15-60 years in both genders. 2. patients with craniospinal post traumatic or post operative csf leakage for more than 24 hours. exclusion criteria: 1. patients with comorbid like cardiovascular, chronic kidney disease, coagulopathies and pregnancy 2. previous history of chest or abdominal surgery. 3. previous history of any lumbosacral surgery.
real-world assessment of clinical outcomes in metastatic nsclc patients with met exon 14 skipping mutation and brain metastases treated with capmatinib

Conditions: Metastatic Non-Small Cell Lung Cancer

Summary: this was a retrospective, noninterventional cohort study of patients with a confirmed diagnosis of metastatic nsclc with met exon 14 skipping mutation and brain metastases (bm) who received treatment with capmatinib in real-world practice settings. the study population consisted of patients with histologically confirmed stage iiib, iiic, or iv met exon 14 skipping mutated nsclc with bm. the date of the initiation of therapy with capmatinib after the date of initial bm diagnosis at or after the initial advanced or metastatic nsclc diagnosis defined the study index date. the 12-month period before the study index date defined the baseline period to assess baseline demographic and clinical characteristics. study measures were assessed at the index and during the baseline and postindex date periods. the index date needed to occur between 1 may 2020 and the date of data abstraction, provided the selected patients meet the requirement of a minimum of 6 months follow-up time available after capmatinib initiation; the exceptions to this are those patients who died during this period.


Eligibility criteria:
inclusion criteria * patient was aged ≥ 18 years at the time of nsclc diagnosis * patient had histologically confirmed stage iiib, iiic, or iv nsclc with met exon 14 skipping mutation at the time of initial nsclc diagnosis * patient had ≥ 1 measurable intracranial lesion after initial diagnosis of bm * patient was treated with capmatinib after diagnosis of bm (any line) exclusion criteria * patients with characterized epidermal growth factor receptor (egfr) and anaplastic lymphoma kinase (alk) mutations that predict sensitivity to epidermal growth factor receptor therapy, including but not limited to exon 19 deletions and exon 21 mutations * patients with other known actionable molecular alterations (such as ros1 translocation or braf mutation) who might be candidates to receive alternative targeted therapies * patients who had been treated with metis in any therapy line before or after the study index date * patients who had participated in a clinical trial related to treatment for nsclc at any time before or after the study index date
neurologic manifestations of covid-19

Conditions: Coronavirus Disease 2019

Summary: this study will determine the neurological profile and predictors of outcomes in patients with covid-19 disease in the philippines. it will also evaluate if there is significant difference between covid-19 patients with neurological manifestations compared to those covid-19 patients without neurological manifestations in terms of various prespecified clinical outcomes. furthermore, the likelihood of these outcomes in covid-19 patients with neurological manifestations compared to those without neurological manifestation will be determined in this study.

this quantitative, retrospective, cohort study will determine the following: 1) demographic, clinical and neurological profile of patients with covid-19 disease in the philippines; 2) the frequency of neurological symptoms and new-onset neurological disorders/complications in patients with covid-19 disease; 3) the neurological manifestations that are significant predictors of mortality, respiratory failure, duration of ventilator dependence, intensive care unit (icu) admission, length of icu stay, and length of hospital stay; 4) if there is significant difference between covid-19 patients with neurological manifestations compared to those covid-19 patients without neurological manifestations in terms of mortality, respiratory failure, duration of ventilator dependence, icu admission, length of icu stay and length of hospital stay; and 5) the likelihood of mortality, respiratory failure and icu admission in covid-19 patients with neurological manifestations compared to those without neurological manifestations.

Eligibility criteria:
inclusion criteria: * cases confirmed by testing approved patient samples (i.e. nasal swabs, sputum, bronchoalveolar lavage fluid) employing the real-time reverse transcriptase polymerase chain reaction (rt-pcr) from covid-19 testing centers accredited by the doh; * adult patients at least 19 years of age; * male or female; * cases with clinical symptoms and signs attributable to covid-19 disease (i.e. respiratory as well as non-respiratory clinical signs and symptoms), with or without the availability of ancillary tests (i.e. complete blood count, chest x-ray); cases with disposition (i.e. discharged or died) at the end of the study period. exclusion criteria: * pediatric patients ≤18 years * cases with conditions of diseases caused by other organisms (i.e. bacteria, other viruses, fungi, etc.) or caused by other pathologies unrelated to covid-19 disease (i.e., trauma).

Keywords: covid-19 neurological manifestations outcomes cohort study
epidemiology study of keloid

Conditions: Keloid

Summary: although keloid is a very common condition; there are no statistics as to its true incidence and prevalence, neither in united states, nor elsewhere in the world. this trial intends to capture epidemiological data about this disease in a large population sample.

the purpose of current trial is to establish a robust database of incidence and prevalence of keloid, as well as prevalence of familial keloid, in various ethnic groups. study sample size is 100,000 random individuals who will fill out either a web survery or a paper questionnaire.

Eligibility criteria:
inclusion criteria: 1. informed consent 2. age above 18 to answer the survey questions 3. parents shall respond on behalf of their minor children exclusion criteria: * none

Keywords: keloid
follow-up of the nasal microbiome and viral infections in newborns hospitalised in neonatology.

Conditions: Microbial Colonization; Viral Infection; Neonatal Infection

Summary: the goal of this interventional study is to learn about nasal microbiome and viral infections in newborns hospitalised in neonatology. the main questions it aims to answer are : * how often are newborns infected by viruses in neonatology ? * how does the microbiome develop during first weeks of life ? * how does microbiome and viruses interacts together ? * is there a link between viral infection, microbiome, and medical complications during hospitalisation in neonatology ? participants will have a nasal swab taken each week during their hospitalisation in neonatology, and researchers will take medical data from the medical chart.


Eligibility criteria:
inclusion criteria: * newborn hospitalised in neonatal intensive care unit during the inclusion period * parents have been informed about the study (speaking french) and have signed the informed consent. * affiliated to the social security system. exclusion criteria: * parental refusal * minor parents or under judicial protection * newborn who already have been discharded home before inclusion * hospitalisation after the first 48 hours of life * only palliative care

Keywords: metatranscriptomics microbiome newborn
the correlation between adenoid hypertrophy and body temperature in children before and after adenoidectomy

Conditions: Otolaryngological Diseases

Summary: examination of the correlation between adenoid hypertrophy and body temperature in candidate children for adenoidectomy after exercise

examination of the correlation between adenoid hypertrophy and body temperature in candidate children for adenoidectomy after exercise. adenoid hypertrophy and adenoiditis are accompanied by chronic rhinitis with or without otitis media. it is very common phenomena at ages 2-6 years and those children are symptomatic with snoring, rhinitis, nasal obstruction. in healthy children with nasal obstruction, body temperature can be elevated following exercise. as adenoiditis and chronic rhinitis are accompanied by inflammatory process, we would like to examine body temperature of children with adenoid hypertrophy before after exercise.

Eligibility criteria:
inclusion criteria: * healthy children with adenoid hypertrophy with or without osa, som parental concent. no other diseases exclusion criteria: * syndromatic children other diseases if getting antibiotics or other medications
effect of dietary fiber on glucose & lipids in non insulin dependent diabetes mellitus (niddm)

Conditions: Non-Insulin-Dependent Diabetes Mellitus

Summary: effect of dietary fiber on glucose, lipid, and mineral metabolism in patients with non insulin dependent diabetes mellitus.

two diets will be compared,a low fiber diet and a high fiber diet. these two diets will differ only in the content of total dietray fiber derived from natural food products. the diets will be identical in terms of total energy, percentage of total energy as proteins, fat and carbohydrates.

Eligibility criteria:
inclusion criteria: * niddm * age 35 to 80 years * stable oral hypoglycemic treatment for at least one month * fasting triglycerides \< 500 mg/dl exclusion criteria: * insulin dependent niddm * insulin dependent diabetes * hepatic disease * significant hepatic dysfunction * signifiacnt renal dysfunction * presence of significant hematological, neurological, cardiovascular or gastrointestinal disorder, unless stable for past 6 months, * serious intercurrent illness or anticipated major surgery * female pregnant or likely to become pregnant * chronic drug abuse, alcoholism or psychaitric disorder within the past 2 years * treated with beta adrenergic blockers * on lipid lowering drugs

Keywords: diabetes lipids fiber
walking therapy in hemiparetic stroke patients using robotic-assisted treadmill training

Conditions: Hemiparesis; Stroke

Summary: the overall goal of this study is to determine whether robotic-assisted gait training is better than standard physical therapy treatments for improving walking ability in hemiparetic stroke patients.

subjects enrolled into the study will be randomly assigned to one of 2 groups. the first group will receive one hour of conventional gait training, consisting of lower extremity strengthening exercises, stretching, and full weight bearing walking as tolerated, with appropriate physical assistance from a therapist. the second group will receive walking therapy using a lokomat, which is a special treadmill that works in conjunction with 2 light-weight robotic arms that assists the subject to move their legs while they try to walk on the treadmill. some of the subject's body-weight will be supported using a harness. during lokomat training sessions, subjects will receive feedback of their walking performance on a computer monitor to help them walk. both groups will be trained for 8-10 weeks, 3 times per week, for 1 hour training sessions (24 total sessions). resources for transportation to the national rehabilitation hospital will be provided to all study participants.

Eligibility criteria:
inclusion: * unilateral brain lesion. * within 6 months post-stroke. * receiving no other therapy targeting function of lower limb. * demonstration of hemiparesis (motor dysfunction in lower limb). * able to walk 5 meters without therapist assistance (walking device only). * able to follow commands and protocol. exclusion: * significant cognitive or communication impairments. * uncontrolled hypertension. * uncontrolled diabetes. * clinical depression.

Keywords: physical therapy locomotion therapy gait training stroke robotics rehabilitation treadmill hemiparetic stroke unilateral brain lesion
development and validation of a blood test for early diagnosis of colorectal cancer

Conditions: Colorectal Carcinoma; Advanced Adenomas (AA)

Summary: this is a prospective, multicenter, case-control study. the aim is to develop an optimized algorithm by combining the levels of molecular markers in plasma together with risk factors for developing colorectal cancer and clinical data of patients diagnosed with crc or aa and healthy individuals.


Eligibility criteria:
inclusion criteria: * patients over the age of 18 who are able to understand the participant information and sign the informed consent. * patients who are going to undergo colonoscopy or surgical resection for tumor (crc). exclusion criteria: * patients who had developed any type of cancer in the 5 years prior to their participation in this study. * patients who have received previous chemotherapy or radiotherapy. * patients diagnosed with non-advanced adenomas, serrated polyps, familial adenomatous polyposis or lynch syndrome. * patients with inadequate bowel preparation for colonoscopy. * patients who have undergone colonoscopy/polipectomy in the previous 5 years. * patients with hemolyzed plasma.