Kornimate/medical-research-clean huggingface dataset:
impact of ureteral stent and sheaths size on post-operative pain

Conditions: Ureteral Stent-Related Symptom; Retrograde Intra-renal Surgery

Summary: the purpose of this study is to determine if post-operative stent size impacts stent-related pain and discomfort.


Eligibility criteria:
inclusion criteria: • patients undergoing a retrograde intra-renal surgery (rirs) (only patients undergoing the procedure for stone treatment will be included) who will require post-operative indwelling ureteral stent placement on a string at the conclusion of the procedure. exclusion criteria: * patients with intra-operative ureteral injury who will require ureteral stent for extended time (more than 10 days, in that case a stent without a string will be used). * patient undergoing ureteroscopy for any indication other than stone extraction. * patients who are currently pregnant as determined by clinical presurgical screening.
mydiabby healthcare vs diary in gestational diabetes mellitus.

Conditions: Gestational Diabetes

Summary: the purpose of the study is to demonstrate the non-inferiority of the onset of maternal, foetal, and neonatal complications for patients who had gestational diabetes mellitus (gdm) and who had been monitored by mydiabby healthcare compared to patients who had a classic glycemic blood monitoring by diary

telesur-gdm is a descriptive and comparative study which will be compared to erd2 study. erd2 (personal data) was a retrospective study leaded in rene dubos hospital. the primary objective was to evaluate de proportion of patients who had a blood screening for type 2 diabetes after having a gestational diabetes and who gave birth between 2013 and 2015 in rene dubos hospital. the primary outcome was the discovery of a diabetes after the ogtt test (75g of glucose), 2 to 3 months after delivery, a fasting blood glucose rate ≥ 1,26 g/l and a plasma glucose after 2 hours ≥ 2g/l * in erd2 study 391 subjects were included. the patients were over 18 years old and had a gestational diabetes and were informed by a survey. the main criteria of maternal and neonatal complications were a maternal high blood pressure, a neonatal jaundice, neonatal hypocalcemia and hypoglycemia, and shoulders dystocia. in this study the patients were followed up with classic diary for glycemic blood rate. * with telesur-gdm study, the objective is to prove the non-inferiority of the new method of monitoring for blood glucose rate (mydiabby healthcare) for patients who had a gestational diabetes and who gave birth between 01/01/2021 and the 31/12/2021. the data will be collected with an informatic secured data base.

Eligibility criteria:
inclusion criteria : * age ≥18 years old * date of delivery between 01/01/2013 and 30/06/2015 or * date of delivery between 01/01/2021 and 31/12/2021 and monitored by mydiabby healthcare * patients who had a gestational diabetes tested according to cngof recommendations exclusion criteria : * patients with type 2 or type 1 diabetes * opposition of the patient for participating to the study * patients who have had a multiple pregnancy

Keywords: diabetes mellitus tele-medicine pregnancy
a pilot trial of a developmental, individual-difference, relationship-bases (dir)/floortime for children with autistic spectrum disorders

Conditions: Autistic Spectrum Disorders

Summary: thirty two children age 2-6 years are recruited into the study and the randomization will be stratified for chronological age and symptom severity into 2 main groups, intervention and control. the intervention group will receive an additional target treatment of dir/floortime parent training intervention, while the control group will continue on their routine care for 3 months. hypothesis: children in the intervention group show much improvement in climbing the developmental "ladder" and declining in the autistic behaviors.


Eligibility criteria:
inclusion criteria: * clinical criteria for autistic disorders according to dsm iv * child is 2 - 6 years of age exclusion criteria: * children with additional medical diagnosis (e.g., genetic syndromes, diagnosed hearing impairment, diagnosed visual impairment or seizures) * children who are geographically inaccessible for follow-up visits * their parents are not literate or known chronic psychiatric or physical illness in the parents
a single arm 48-week follow-on safety study to a core study comparing the efficacy and tolerability of tobrineb®/actitob®/bramitob® versus tobi®

Conditions: Cystic Fibrosis

Summary: this is a 48-week extension study to cma-0631-pr-0010 core study. patients who have a positive culture for p. aeruginosa at visit 4 of the first 8-week core study period and/or if deemed appropriate by the investigators will be able to be included in the 48-week follow-on period (extension study) to continue the treatment only with bramitob® (tobramycin nebuliser solution, 300 mg twice daily in 4 ml unit dose vials).


Eligibility criteria:
inclusion criteria: * successful completion of core study * at least 6 years of age * males and females

Keywords: cystic fibrosis p. aeruginosa tobramycin
ketamine in bariatric surgery

Conditions: Morbid Obesity

Summary: ketamine may improve recovery from bariatric surgery.


Eligibility criteria:
inclusion criteria: * age \> 18 * obesity (body mass index \> 30) * asa classificazion \< 4 * candidate to bariatric surgery exclusion criteria: * known or presumed pregnancy * previous surgery on the airway, esophagus or stomach * uncontrolled psychiatric symptomatology

Keywords: pain mood depression respiration
dose-effect relationship of tai chi on health promotion in different age groups

Conditions: Sleep Disorder; Cardiovascular Diseases; Hypertension; Cognitive Impairment; Metabolic Disease

Summary: the purpose of this study is to investigate the physical and mental health status of middle-aged and elderly people of different ages and practicing tai chi for different periods of time, so as to provide a strong theoretical basis and practical guidance for delaying age-related aging and preventing and treating the occurrence and development of chronic diseases.


Eligibility criteria:
inclusion criteria: * men and women aged 20-79 years. * people who practice tai chi for a long time. * people with long-term exercise habits. * people who have no habit of exercising. exclusion criteria: * people currently participating in other interventions (e.g., nutrition, psychological, exercise, health education). * people with cognitive impairment and movement disorders. * cardiovascular and cerebrovascular events (physician-diagnosed heart disease, such as coronary heart disease, hypertensive heart disease, acute myocarditis, pulmonary heart disease, etc.) in the past 6 months. * people with other serious chronic diseases, such as asthma, cancer, chronic heart failure, severe depression, or other mental disorders.
myocardial perfusion study to detect coronary microvascular abnormality in diabetic patients with nonfatal myocardial infarction

Conditions: Myocardial Infarction

Summary: the goal of this study is to use mce (myocardial contrast/perfusion echocardiography) to study and compare short/long term change of myocardial perfusion abnormality and cardiac outcome in diabetic patients after nonfatal mi (heart attack), who are treated with different glucose control agents.


Eligibility criteria:
inclusion criteria: * diabetic and nondiabetic patients will be initially recruited and studied after acute nonfatal mi and revascularization with either pci or cabg exclusion criteria: * patients are excluded if they are older than 70 year old, require mechanical ventilation, are receiving intravenous pressors or hemodynamic support, or if the motion of segments associated with infarct-related artery can not be accurately determined.
autologous platelet enriched gel versus metalloproteinase inhibitor in the healing of chronic lower leg ulcers

Conditions: Chronic Lower Leg Ulcer

Summary: compare autologous platelet enriched gel versus metalloproteinase inhibitor in the healing of chronic lower leg ulcers.


Eligibility criteria:
inclusion criteria: * 18 year or older * a non-healing chronic lower leg ulcer * platelet ranges of 150000 per ml circulating blood exclusion criteria: * presence of a tumor or metastatic disease * hypersensitive to collagen regenerated cellulose * hemodynamic unstable patient * hypercoagulability * heart decompensation or angina pectoris
the glycemic effect of added sugar on bake beans

Conditions: Diabetes Mellitus, Type 2; Obesity; PreDiabetes

Summary: to investigate the effect of added sugar to bake beans on glycemic and insulinemic response.

there will be a total of 7 test session. each session will last for 3 hours. at each test session, volunteers will be served with 7 test meals and blood will be collected. after an overnight fast, subjects will visit the research center. two fasting capillary blood samples will be collected via fingerpick. following the fasting samples, volunteers will consume the test meals. further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. these samples will be used to analyses for whole capillary blood glucose. at every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

Eligibility criteria:
inclusion criteria: * chinese ethnicity * age ≥21 and ≤ 60 years * body mass index between 18.5 to 25 kg/m2 * normal blood pressure \<140/90 mmhg * fasting blood glucose \<6.0 mmol/l * in general good health exclusion criteria: * current smoker * have any metabolic diseases (such as diabetes, hypertension etc) * have known glucose-6-phosphate dehydrogenase deficiency (g6pd deficiency) * having medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics) * have intolerances or allergies to any foods * partake in sports at the competitive and/or endurance levels * intentionally restrict food intake
study for patients with non small cell lung cancer (nsclc)

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: this is a randomized study to assess the efficacy and safety of chemotherapy with platin compared to chemotherapy without platin.

randomized phase ii design, multicenter study, to assess the efficacy and safety of combined chemotherapy with paclitaxel and carboplatin versus a platinum free chemotherapy with paclitaxel and vinorelbine, within the combination therapies there are two different dosing intervals, which will be assessed as well (4 arm study).

Eligibility criteria:
inclusion criteria: * chemotherapy naive patients with histologically confirmed nsclc stage iii and iv exclusion criteria: * new york heart association (nyha) iii or iv * brain metastases * neurotoxicity grade 2 or greater

Keywords: nsclc curative non-treatable nsclc uicc stage iiib and iv
study on the effect of prostacyclin compared to placebo in traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: this study is a prospective consecutive double-blinded randomized study on the effect of pgi2, prostacyclin (epoprostenol, flolan®) versus placebo (saline)in patients with severe traumatic brain injury. all patients with severe traumatic brain injury were eligible for inclusion. inclusion criteria: verified traumatic brain injury, glasgow coma score (gcs) at intubation and sedation of ≤ 8, age 15-70 years, a first-recorded cerebral perfusion pressure (cpp) of \> 10 mm hg, and arrival within 24 hours after trauma. tne primary aim was to evaluate whether treatment with epoprostenol would reduce a lactate/pyruvate ratio,as measured by cerebral microdialysis after 24 hours of treatment. a secondary aim was to evaluate the effect of epoprostenol on systemic inflammatory markers, measured by different cytokines.


Eligibility criteria:
inclusion criteria: * traumatic brain injury, glasgow coma scale ≤ 8 exclusion criteria: * pregnant or lactating women

Keywords: traumatic brain injury
efficacy of telerehabilitation intervention program using telebiofeedback among computer operators

Conditions: Work Related Musculoskeletal Disorders

Summary: in the recent decades, with technology development, computer workstation has become fundamental both at work and at home environments, and is now used routinely for many purposes. musculoskeletal disorders (msd) are most often characterized by backaches, neck and upper extremities pain, discomfort and pain in joints, muscles and soft tissues. since it has been found that many musculoskeletal disorders are connected, among others, to biomechanical and psychosocial factors relating to a person's work environment, the literature refers to them as work related msd (wrmsd). risk factors correlated with wrmsd include repetitive motions, awkward positions or static muscle loading over prolonged periods of time, use of high keystroke force, direct mechanical pressure, vibration and extreme temperatures. computer operators found to be sitting statically for a long time in front of the computer and keyboard, with limited options of changing body position. psychosocial factors have also been implicated in the workstation musculoskeletal disorders with computer operators. workers with wrmsd may suffer from persistent pain, loss of function and work disability. therefore, it may include changes in the employment and earnings for injured workers. the complex nature of these injuries suggests that workplace rehabilitation interventions are a crucial aspect of treatment management. the main objective of this study is to explore the use of biofeedback intervention, based on tele-rehabilitation principle, with computer operators suffer from wrmsd. treatment efficacy will be tested by use of rula (rapid upper limb assessment) method. data analysis will be done by anova repeated measures. hypothesis: biofeedback intervention, based on tele-rehabilitation principle, will be found effective with computer operators suffer from wrmsd.


Eligibility criteria:
inclusion criteria: * computer operators who spend more than 4 hours a day working with computer * computer operators who suffer from pain and inconvenience or injury in upper limbs, such as lateral epicondylitis, de quervain disease, carpal tunnel syndrome (cts), ulnar tunnel syndrome, flexor-extensor peritendinitis or teno-synovitis of the forearm-wrist region. exclusion criteria: * subjects who suffer from neurological injuries * subjects who suffer from orthopedic injuries or other metabolic or autoimmune diseases, that cause joint oedema or hand numbness (pregnancy, diabetes, heart disease and arthritis).

Keywords: work related musculoskeletal disorders (wrmsd) among computer operators
impact of current smoking in the tolerance of bronchoscopy

Conditions: Smokers

Summary: the purpose of this study is to study the impact of smoking in the preceding hours before a bronchoscopy on the tolerance of this exam.

tolerance evaluation of the bronchoscopy on current and regular smokers. the investigators assess episodes of cough, dyspnea, volume of lidocain (liquid 1% and in spray 10%), duration of the procedure, episodes of desaturation and completion of the bronchoscopy. the investigators compare patients who did not smoke in the 6 hours before the bronchoscopy and those who have smoked.

Eligibility criteria:
inclusion criteria: * current and regular smoker * bronchoscopy under local anesthesia exclusion criteria: * patients needing ebus or fluoroscopy * intravenous sedative

Keywords: smoking bronchoscopy cough
amblyopia and strabismus detection using a pediatric vision scanner

Conditions: Amblyopia; Strabismus

Summary: the purpose of this project is to compare the performance of the pediatric vision scanner (pvs) with the gold standard examination to determine the effectiveness of the pvs at detecting amblyopia and strabismus.


Eligibility criteria:
inclusion criteria: * children aged 3-8 years * signed informed consent by parent or guardian * meet all inclusion criteria. exclusion criteria: * children with a history of developmental delay or cognitive deficit * children unable to complete the gse (including visual acuity testing)
effect of omalizumab (xolair) on basophils in patients with chronic idiopathic urticaria

Conditions: Chronic Urticaria

Summary: this study looks at changes in cell proteins in people with chronic hives treated with omalizumab.

the purpose of this study is to evaluate for changes in the proteins produced in white blood cells (basophils) in patients with chronic hives who are treated with and respond to omalizumab.

Eligibility criteria:
inclusion criteria: * chronic urticaria (hives) for more than 6 weeks. * no improvement with standard doses of antihistamines (loratadine 10 mg daily, desloratadine 5 mg daily, fexofenadine 180 mg daily, cetirizine 10 mg daily, or levocetirizine 5 mg daily) exclusion criteria: * taken any oral steroids for 1 month prior to beginning the study. * taken any other immunomodulatory drugs (sulfasalazine, hydroxychloroquine, cyclosporine, methotrexate) for 1 month prior to beginning the study. * physical urticaria as a primary diagnosis. * known allergic precipitant of urticaria such as foods. * urticarial vasculitis. * anemia. * asthma. * serum immunoglobulin e (ige) \>700 iu/ml. * women of childbearing potential not using contraception method(s), as well as women who are pregnant and/or breastfeeding. * known sensitivity to omalizumab or this class of drug. * use of any other investigational agent in the last 1 month. * untreated intercurrent illness.

Keywords: chronic idiopathic urticaria ciu urticaria chronic hives xolair
prevalence of malnutrition in oncologic patients

Conditions: Cancer; Malnutrition

Summary: malnutrition is a common phenomenon in cancer patients. deteriorated nutritional status is associated with poor clinical outcome. the purpose of this study is to determine the prevalence of hospital malnutrition and its impact on functionality, quality of life and mortality in cancer patients and to test the reference percentiles of phase angle values (bosy westphal et al jpen 2006) as indicator of cancer cachexia and predictor of mortality. hypothesis: the fifth reference percentile of the phase angle norm values is a prognostically relevant cut off value indicating cancer cachexia in terms of malnutrition, fatigue and impaired functional status, as well as predictive of 6-month mortality


Eligibility criteria:
inclusion criteria: * patients suffering from cancer. * patients who have signed a written informed consent. exclusion criteria: * patients with implanted pacemaker or defibrillator * patients with neuromuscular disease or hemiplegia.

Keywords: mortality functional status
effectiveness of trephination with platelet rich plasma or placebo in a primary meniscal tear treatment

Conditions: Meniscus Lesion

Summary: this study will compare meniscal healing augmented or without augmentation with platelet rich plasma in primary meniscal tear treatment (prolotherapy). the assessments will include validated, disease specific, patient oriented outcome measures. results of this study will help ascertain whether platelet rich plasma may improve meniscal healing rates.

the role of meniscal in the knee integrity is pivotal and lack or partial role of the meniscus increases rate of joint degeneration. partial meniscal removal is the most popular procedure and meniscal repair remain in minority of arthroscopic surgeries. as criteria of inclusion to meniscal repair are very rough, still success rates of meniscal repair remain in the 60-80% range for isolated repairs. this rate is greater when performed with acl reconstruction. the investigators believe that augmentation with platelet rich plasma as prolotherapy ill induce healing without the need for arthroscopy.

Eligibility criteria:
inclusion criteria: * complete horizontal 10 mm in length * tear located in the vascular/avascular portion of the meniscus (chronic horizontal tear on mr) * single tear of the medial and/or lateral meniscus * skeletally mature patients 18-70 years of age exclusion criteria: * discoid meniscus * arthritic changes (kellgren lawrence scale \>2) or axial leg deformity (valgus \> 6 deg) * inflammatory diseases (i.e. rheumatoid arthritis) * concominant chondral defects (\> 2 icrs)

Keywords: meniscus repair platelet rich plasma
pulse oximetry with clinical observation to screen for lung disease in neonates

Conditions: Lung Diseases

Summary: the investigator assessed the feasibility and reliability of pulse oximetry plus clinical observation for detection the lung disease in neonates.

at present respiratory disease(rds) diagnose base on clinical symptom and chest x-ray.but in china, because of the difference of medical conditions, some areas especially the basic level hospitals without the condition of x-ray examination, which can not be clearly diagnosed rds.in 2013, the scholars analyzed the disease of neonatal intensive care unit (nicu) need to be exposed to radiation, and rds was in the first place. there is no conclusion whether it bad for newborn to exposure more. but in animal models, there is a correlation between exposure to radiation and cancer. hyaline membrane disease(hmd) is common occur in preterm infants .pulmonary surfactant(ps) is a safe and effective treatment for neonatalhmd.bahadue f l meta analyse conclusion is early application of ps is more benefit for hmd. so investigator hypothesize that pulse oximetry with clinical assessment have high sensitivity,specificity ,positive and negative predictive value to lung disease.the aim is to reduce radiation exposure to neonate and to preterm infants with rds can early application of ps. symptomatic definition:with grunting,nasal flaring,retraction,cyanosis,tachypnea,stridor. pulse oximetry positive criteria:1.atrial oxygen saturation (spo2)\ 180 or \<100 per minute. clinical assessment:1.respiratory physical examination:non-symmetry,decrease breathing sound,bubbles sound.2.delivery history:caesarean,premature rupture of membranes,liquor,mother conditions,apgar score. congenital heart disease classification:1.critical:defects causing of the death or needing intervention before 28 days.2.serious:defects needing intervention before 1 year of age.significant:defects persisting longer than 6 months of age ,but not classified as critical or serious.4.non-significant:defects not physically appreciable and not persisting after 6 months of age.

Eligibility criteria:
inclusion criteria: 1. gestation age :28 to 42 weeks 2. birth weight :1000-4000g 3. asymptomatic or symptomatic respiratory symptom exclusion criteria: 1. gestation age \ 42 weeks 2. birth weight \ 4000g 3. critical and serious heart disease 4. congenital malformation

Keywords: pulse oximetry clinical assessment neonate lung disease