Kornimate/medical-research-clean huggingface dataset:
micro-transplantation in elderly patients with acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: this study aims at evaluating the safety and the tolerance of the micro-transplantation in elderly patients with acute myeloid leukemia who are ineligible to conventional allogeneic transplantation.

acute myeloid leukemia (aml) is an aggressive hematological malignancy with a median age at diagnosis of 65 years. outcomes of aml in elderly population remain unsatisfactory with low rates of complete remission, poor disease-free and overall survival. therapeutic management of older patients with aml deals with patient-related features (i.e. comorbid conditions and performance status) as well as disease-related prognostic factors (i.e. cytogenetics and molecular genetics). even if allogeneic hematopoietic-cell transplantation provides the strongest antineoplasic effect, this treatment option remains limited for older patients owing to toxicities, the development of significant graft-versus-host disease (gvhd) and logistics of donor availability. more recently, micro-transplantation has emerged as an alternative strategy based on the infusion of mobilized hla-mismatched related donor cells after induction chemotherapy, thus exerting a graft-versus-leukemia effect without substantial donor engraftment and gvhd. therefore, there is much of interest in investigating the efficacy and the safety of this method for older patients with aml who are not candidates for allogeneic stem cell transplantation.

Eligibility criteria:
inclusion criteria: * patient affiliated to a social security regimen or beneficiary of the same * signed written informed consent form * patient, ≥ 60 years-old - \< 75 years-old, with established diagnosis of de novo or secondary aml with intermediate-risk or adverse-risk cytogenetic profile, or with established myelodysplasic syndromes (raeb), in pathologically confirmed complete remission following anti-leukemic induction therapy (\<5% blasts) * contra-indication to conditioning regimen in conventional allogeneic transplantation exclusion criteria: * patient with established diagnosis of acute myeloid leukemia with standard-risk cytogenetic profile * promyelocytic leukemia t(15;17) * cbf-aml t(8;21) or inv(16) * normal karyotype with a favorable molecular profile: npm1+ and flt3-; npm1+, flt3- and double mutation cebpα or chronic myeloid leukemia in blastic phase * patient under guardianship or deprived of his liberty or any condition that may affect the patient's ability to understand and sign the informed consent * refusing participation

Keywords: acute myeloid leukemia micro-transplantation elderly graft-versus-leukemia
randomized phase iii trial with docetaxel plus epirubicine versus docetaxel plus capecitabine for metastatic breast cancer

Conditions: Breast Cancer

Summary: the combination of docetaxel+epirubicin is highly effective and well tolerated as first line treatment in patients with metastatic breast cancer (mbc). capecitabine is an active drug in women with mbc pretreated with taxane and anthracycline. docetaxel increases the intracellular levels of thymidilate phosphorylase and thus is synergistic with capecitabine. the combination of docetaxel plus capecitabine is highly active and superior to docetaxel monotherapy in women with mbc pretreated with an anthracycline

this trial will compare the efficacy of docetaxel plus epirubicin versus docetaxel plus capecitabine combinations as first line treatment in women with mbc

Eligibility criteria:
inclusion criteria: * histologically- or cytologically- confirmed metastatic breast adenocarcinoma. * no previous chemotherapy treatment for metastatic disease. * no previous anthracycline treatment except as adjuvant therapy at least one year before. * age 19-75 years old * presence of measurable disease * performance status 0-2 (who) * adequate cardiac function (lvef \>50%) without a recent (within 6 months) history of myocardial infraction and/or unstable or uncontrolled angina. * adequate bone marrow(absolute neutrophil count \>1500/mm3, platelet count \>100.000/mm3, hemoglobin \>10gr/mm3), liver (bilirubin \<1.5 times upper limit of normal and sgot/sgpt \<2 times upper limit of normal) and renal function (creatinine \<2mg/dl). * no previous radiotherapy to more than 25% of marrow-containing bones. * written informed consent exclusion criteria: * active brain metastases. * psychiatric illness or social situation that would preclude study compliance * other concurrent uncontrolled illness. * other invasive malignancy within the past 5 years except of nonmelanoma skin cancer. * positive pregnancy for premenopausal women. * concurrent antineoplastic treatment e.g. hormonal therapy

Keywords: metastatic breast cancer; first line chemotherapy; docetaxel; epirubicin; capecitabine
exploratory study using a new head-only pet scanner / exploreneurolf

Conditions: Brain Diseases

Summary: the "neurolf prototype" is a small aperture pet scanner. the neurolf prototype will be used with patients, which have just finished their regularly scheduled pet examination on a clinical whole body pet system. the radioactive tracer used for this procedure will still be active. this remaining acitivity will be used for an image acquisition with the neurolf prototype without the need for an additional radioactive tracer dose. the control intervention is be a brain pet scan as part of standard clinical routine. it will be done immediately before the scan on the neurolf prototype.


Eligibility criteria:
inclusion criteria: * capable of giving informed consent as documented by signature (appendix informed consent form). * ability to sit still in the head-only pet scanner for 15 minutes. * are scheduled to receive a regular brain pet scan as part of clinical routine. * male and female patients 18 years to 80 years of age. exclusion criteria: * contraindications to pet examination, * patient height smaller than 160 cm or taller than 200 cm, * patient weight more than 120 kg, * patient cannot sit upright for at least 15 minutes, * metal implants in the head, * pregnant or breastfeeding women, * known or suspected non-compliance, drug or alcohol abuse, * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant, * participation in another study with investigational drug/device within the 30 days preceding and during the present study, * previous enrolment into the current study, * enrolment of the investigator, his/her family members, employees and other dependent persons.
effect of antioxydant-enriched media on blastocyst euploidy rates.

Conditions: Infertility; In Vitro Fertilization

Summary: one of the most sensible factors in ivf culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ros) caused by the artificial environment. this study aims to evaluate the impact of using antioxidant-supplemented media during culture to evaluate embryo ploidy rates in a prospective randomized trial using sibling oocytes.

improvements in culture conditions is an ongoing process in ivf due to, on one hand, the still lack of knowledge on human embryonic development, and, on the other hand, the frequent need for repeated ivf cycles to achieve an 'implantable' embryo. the main factor for optimizing conditions of an embryo to develop is its microenvironment, mainly the culture media used. one of the most sensible factors in ivf culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ros) caused by the artificial environment, as it has been extensively shown in animal models and to a certain extent in humans. a primordial step for improvement is to alleviate an increase in ros during embryo development. this can be manipulated by means of utilizing a culture media with supplements that can serve as scavengers, leading to an equilibrium between oxidation and reduction of ros during the culture period. so far, the produced culture media contain low concentrations of limited additives involved in anti-oxidative stress. recently, a culture medium containing an implementation in higher doses of distinctive elements known to clearly serve as cellular scavengers has been formulated. however, very few human ivf studies have been performed up to date. our research intends to investigate the incorporation of antioxidant-rich culture media into ivf practices with the primary objective of analyzing its impact on embryo euploidy, as well as the previous culture steps including fertilization and blastocyst developmental rates. this study aims to evaluate the impact of using antioxidant-supplemented media during culture to evaluate embryo ploidy rates in a prospective randomized trial using sibling oocytes.

Eligibility criteria:
inclusion criteria: * patients undergoing assisted reproductive technology cycles when icsi is indicated. * patients when iin vitto fertilization (ivf) is also performed will be included as far as there are enough oocytes for icsi randomization. however, ivf oocytes will not be used for the study. * maternal age 18-43 years old. * pgt-a cycles with only trophectoderm biopsies on day 5/6/7. * patients with more than 6 cocs expected for icsi. * body mass index \<35. * fresh and frozen ejaculated sperm. exclusion criteria: * pgt-m cycles * fresh and frozen testicular sperm.

Keywords: intracytoplasmic sperm injection pre - implanttaion genetic diagnosis for aneuploidy antioxydante culture media embryo development euploidy
the effect of patient preference on retention success

Conditions: Malocclusion; Orthodontic Retention

Summary: aim of the study: to determine whether allowing the patient to choose the type of retainer affects the success of retention in terms of stability and patient satisfaction. hypothesis: allowing the patient to choose their retainer can increase the success of retention. design: two-arm parallel group randomized controlled clinical trial

this study investigates whether allowing patients to choose the type of retainer-fixed or removable-affects the success of orthodontic retention in terms of stability and patient satisfaction. the hypothesis is that patient autonomy in selecting their retainer type can enhance retention success. conducted as a two-arm parallel group randomized controlled trial, the study involves patients who have completed fixed appliance treatment. participants are randomly assigned to either the intervention group, where they choose their retainer type after being informed of the pros and cons, or the control group, where the clinician decides the retainer type. the primary outcome of the study is the stability of the orthodontic treatment, with secondary outcomes including retainer survival, oral health, and patient satisfaction. stability is measured using indices such as little's irregularity index, inter-canine width, and overjet, among others. oral health is evaluated based on caries presence, sulcus depth, and gingival bleeding. retainer survival is monitored by incidents of losing or breaking the retainer. patient satisfaction is assessed through a detailed questionnaire covering aspects such as retainer usage, comfort, and perceived value. due to the nature of the intervention, blinding is not possible for operators, participants, or assessors. this study aims to provide insights into how patient choice influences the outcomes of orthodontic retention, potentially guiding future clinical practices towards enhanced patient satisfaction and treatment success. this study aims to provide valuable insights into the impact of patient autonomy on orthodontic retention outcomes. by comparing patient-chosen and clinician-chosen retainer types, the research seeks to enhance our understanding of factors contributing to successful orthodontic retention and overall patient satisfaction.

Eligibility criteria:
inclusion criteria: 1. patients older than age 12 2. patients who have been treated with fixed orthodontic appliances 3. patients with good standard of oral hygiene exclusion criteria: 1. patients with initial diastema or other significant spacing 2. patients with dentofacial syndromes/cleft lip and palate 3. patients who had orthodontic treatment before 4. patients with hypodontia (more than one tooth missing, except third molars) 5. patients who have undergone orthognathic surgery
operative difficulty grading scale for laparoscopic cholecystectomy in bpkihs

Conditions: Laparoscopic Cholecystectomy

Summary: the main purpose of this study is to utilize operative grading scale to predict conversion to open,complication and reintervention and validate nassar scale.

laparoscopic cholecystectomy is the commonly performed procedure in our institute. laparosopic cholecystectomy is high variable surgery ranging from simple routine operation to difficult surgery leading to increased morbidity and mortality. the majority of previous scores use a combination of pre-operative and operative data and were produced in studies that were limited by retrospective data, small sample sizes and lack of external validation. very few intraoperative difficulty grading scale was published and none are widely used in clinical practice. so operative grading scale will have advantages of assisting in intra-operative strategy and planning, allowing comparison across different research studies, facilitating risk adjustment for surgical outcomes and providing an aid in training surgeons and monitoring of training progression. the main purpose of this study is to utilize operative grading scale to predict conversion to open,complication and reintervention.

Eligibility criteria:
inclusion criteria: * all patients undergoing laparoscopic cholecystectomy exclusion criteria: * cbd stone * malignancy of extrahepatic biliary tree * cholecystectomy as a part of other surgery

Keywords: surgery laparoscopic cholecystectomy cholecystitis
weight management aimed to reduce risk and improve outcomes from radical prostatectomy

Conditions: Obesity; Prostate Cancer

Summary: the purpose of this study is to test how a weight management program affects substances in the blood called biomarkers that can show the presence or severity of cancer, compared to a standardized diet and exercise educational flyer.


Eligibility criteria:
inclusion criteria: * men newly diagnosed with pca who are scheduled for radical prostatectomy (rp) (t1 or t2) * body mass index (bmi) 25-45 kg/m2 * has internet access exclusion criteria: * history of 5 alpha reductase inhibitors prior 3 months * history of radiation therapy for cancer treatment * taking active cancer treatment * undergoing salvage therapy * castration-resistant pca * evidence of metastasis * evidence of biochemical recurrence * high risk medical condition (e.g. kidney disease, uncontrolled diabetes, etc.)
ovarian stimulation with fsh alone versus fsh plus gnrh antagonist in an oocyte donor/recipient programme

Conditions: Premature Luteinisation; Progesterone Elevation

Summary: the aim of this study is to compare the efficacy of a protocol using fsh alone with that of a protocol using fsh plus a gnrh antagonist for controlled ovarian hyperstimulation in cycles of elective freezing in the context of a donor/recipient programme.

the hypothesis to be tested is that an ovarian stimulation protocol that includes fsh alone without any lh surge prevention regimens is not inferior to a protocol including fsh plus a gnrh antagonist in terms of clinical outcome in a donor/recipient model. the formal sample size is calculated as follows: if there is a true difference in favour of the experimental treatment of 5% (20% vs 15%), then 160 patients (80 per group in case of 1:1 enrolment) are required to be 80% sure that the upper limit of a one-sided 95% confidence interval (or equivalently a 90% two-sided confidence interval) will exclude a difference in favour of the standard/control group of more than 10%. in the context of the present pilot study (as a first stage), the investigators intend to study 50 patients (25 per group in case of 1:1 enrolment). at a second stage the above mentioned sample size will be used.

Eligibility criteria:
inclusion criteria: * healthy women 21-32 years old with a bmi of 21 to 29 kg/m2 who wish to donate their oocytes * normal ovarian reserve tests * normal menstrual cycles of 26-32 days * the women would not have received any hormonal treatment during the last three months before entering the study. * absence of coagulation and/or autoimmune disorders. exclusion criteria: 1. use of other protocols towards oocyte retrieval, such as natural, or modified natural cycles 2. poor ovarian response according to the bologna criteria \[22\], 3. history of endocrine or metabolic disorders, ovarian cystectomy or oophorectomy, 4. women with the diagnosis of polycystic ovary syndrome 5. clinical and/or laboratory markers of hereditary or acquired thrombophilia that complied to the standard protocols of each unit. * non-hormonal medication for a serious medical condition

Keywords: controlled ovarian stimulation gnrh antagonist oocyte donation lh surge
effect of progressive relaxation exercises and tens on women delivering via cesarean

Conditions: Cesarean Section; Acute Pain

Summary: this study aimed to determine the effect of progressive relaxation exercises and transcutaneous electrical nerve stimulation administered to women delivering via cesarean section on acute pain, breastfeeding behavior, and comfort levels. single-blind, randomized controlled study. this study was carried out in the obstetrics and gynecology clinic of a university hospital affiliated with the ministry of health in turkey between august 20, 2018 and april 15, 2019. a total of 120 participants were randomly assigned to one of four groups, which included a transcutaneous electrical neural stimulation (tens) group, a progressive relaxation exercises (pre) group, a combined intervention (tens+pre) group, and a control group. data were collected with a data collection form, the visual analogue scale (vas), the latch breastfeeding diagnostic tool (latch), and the postpartum comfort scale (pcs). in the analysis of the data, numbers, percentages, and chi-square tests were used. also, median values, wilcoxon signed-rank test, and kruskal-wallis h test were employed for continuous variables.


Eligibility criteria:
inclusion criteria: * women who were aged between 18 and 45, * who were in the postoperative 8th hour, * who had a transverse cesarean section, * who, as well as their babies, did not develop any complications during pregnancy, delivery, and the postpartum period. exclusion criteria: * women who did not have an open wound on their body and/or allergic disease on their skin, * who had cardiac arrhythmia or a pacemaker, * who had a risk of epilepsy, * who had epilepsy, eclampsia, kidney or liver disease, * who had previously applied tens and pre methods, * who were morbidly obese (with a bmi value of over 40), * who used chronic opioids, antidepressants, and psychoactive drugs.

Keywords: cesarean section pain breastfeeding comfort muscle relaxation transcutaneous electrical neural stimulation
redwil: reduction of wound infections in laparoscopic colon resections by wound protectors

Conditions: Colorectal Surgery; Wound Infections

Summary: surgical site infection is common in colorectal surgery leading to increased postoperative pain, longer hospital stay, delayed wound healing and increased re-operation rates. hence, reducing the wound infection rate is a major aim in abdominal surgery. wound protectors were invented for retracting the abdominal wall and keeping the abdominal wall sterile in order to reduce bacterial colonialization of the wound and wound infections. this is a prospective-randomized trial comparing use of wound protectors versus woven drapes in laparoscopic colon resections with minilaparotomy.


Eligibility criteria:
inclusion criteria: * elective laparoscopic colorectal resection with minilaparotomy exclusion criteria: * emergency operation * patients under 18 years of age

Keywords: colorectal surgery wound infection wound protector laparoscopy surgical site infection after laparoscopic colorectal surgery with minilaparotomy
assessment the cancer risk of indeterminate thyroid nodules through integration of clinical, ultrasonographic and multiomic features

Conditions: Thyroid Nodule; Thyroid Cancer

Summary: indeterminate thyroid nodules have a mild risk of malignancy (15-30%). the aim of our study is to individuate new biomarkers of thyroid carcinoma through multiomic analyses of blood samples and of specimen samples of patients with indeterminate thyroid nodules.


Eligibility criteria:
inclusion criteria: * patients with indeterminate thyroid nodules (class iii and class iv according to bethesda classification of thyroid nodules) exclusion criteria: * patients with concomitant thyroid nodules of bethesda class v or class vi * patients with preoperative diagnosis of lymph node metastases of central or lateral neck compartment * patients with distant metastases

Keywords: thyroid carcinoma indeterminate thyroid nodule genomics proteomics metabolomics
shift characteristics affect handover duration and rates.

Conditions: Handover Duration

Summary: the primary aim of our study was to analyze the independent factors affecting handover duration in emergency department. the secondary aim was to identify the factors affecting emergency department handover rates.

the primary aim in this study was to analyze the independent factors affecting handover duration in emergency department. our secondary aim was to identify the factors affecting the emergency department handover rates. to better analyze independent variables, we dichotomized the data. first, we dichotomized handover duration into two groups according to the median handoff time of 20 minutes. second, we divided handover rates into two groups using the median rate of handovers per shift, which was 3.87%.

Eligibility criteria:
inclusion criteria: the day and night shift handover , which are the interactive, verbal, bedside, and face-to-face interactions between the outgoing and incoming medical staff, were included. exclusion criteria: handover locations other than bedside (n=3), handover methods except verbal communication (by paper (n=2)), and the use of information technology (n=1) were excluded to standardize the procedure.

Keywords: handoff signoff handover sign-out shift change emergency department