Kornimate/medical-research-clean huggingface dataset:
[18f]fapi pet/ct in suspicious focal liver lesions without fdg avidity

Conditions: Liver Cancer

Summary: fibroblast activation protein (fap) is a serine protease that belongs to the dipeptidyl peptidase-iv (dpp-iv) family located in fbroblast membranes. fap is overexpressed in the cancer-associated fbroblasts (cafs) of 90% of epithelial carcinomas, including primary and metastatic liver cancer. we aim to conduct a prospective study to investigate the diagnostic perfoemance of 18f-fapi pet/ct in evaluating suspicious liver mass without fdg avidity.

fibroblast activation protein (fap) is a serine protease that belongs to the dipeptidyl peptidase-iv (dpp-iv) family located in fbroblast membranes. fap is overexpressed in the cancer-associated fbroblasts (cafs) of 90% of epithelial carcinomas, including primary and metastatic liver cancer. therefore, fap-targeted radiopharmaceuticals can be considered a promising approach for visualizing cafs. cafs are crucial components of the tumor stroma, promote the growth of cancer cells, and are associated with poor prognosis. currently, 18f-labelled fbroblast activation protein inhibitor 18f-fapi has shown promising diagnostic value in many types of tumors, especially those in which are not avid for 18f-fdf , and several studies have demonstrated that 18f-fapi pet/ct is superior to 18f-fdg pet/ct for detecting liver cancer and has lower tracer uptake in normal liver tissue. we aim to conduct a prospective study to investigate the diagnostic performance of 18f-fapi pet/ct in evaluating suspicious liver mass without fdg avidity.

Eligibility criteria:
inclusion criteria: * patients with suspected liver malignant lesions based on traditional diagnostic imaging (ct or mri or ultrasound) and clinical symptoms; * patients underwent \[18f\]fdg pet/ct with negative findings (suspicious primary and/or metastatic lesions were hypo- or isometabolic on \[18f\]fdg pet/ct); * patients who agreed to undergo \[18f\]fapi pet/ct scans within 1 week. exclusion criteria: * pregnancy; * age\<18 years old; * patients with chemo/radio/targeted therapy before scanning; * inability to provide informed consent (signed by participant, parent, or legal representative).
return of continence following robot-assisted radical prostatectomy with or without a urethrovesical sling

Conditions: Urinary Incontinence; Prostate Cancer

Summary: the purpose of this study is to determine the impact of an absorbable urethrovesical sling on the post-operative return of urinary continence after robot-assisted radical prostatectomy.


Eligibility criteria:
inclusion criteria: * patients must have organ confined prostate cancer. * patients must have psa\< 15. * patients must have clinical stage prostate cancer \< ct3. * patients must be scheduled for robot assisted transperitoneal laparoscopic radical prostatectomy. * patients must be able to provide written informed consent and hipaa authorization for release of personal health information. * patients must be at least 18 years of age. exclusion criteria: * patients must not have previously undergone transurethral resection, laser therapy, microwave therapy, radiofrequency ablation, or other surgery of the prostate. * patients must not have previously undergone incision of urethral stricture or incision of bladder neck contracture. * patients must not have previously been diagnosed with urethral stricture, bladder neck contracture or urinary incontinence. * patients must not have previously been diagnosed with atonic bladder or neurogenic bladder. * patients must not have significant pre-operative voiding symptoms as defined by an american urologic association symptom score of greater than 19. * patients must not have a prior history of radiation to the pelvis. * patients must not have persistent bacteriuria that cannot be cleared, as demonstrated by a negative urinalysis or urine culture, within 1 month of surgery. * patients must not have allergies to pig tissue or pig products or have religious or cultural objection to the use of pig tissue.

Keywords: prostate cancer prostatectomy incontinence
trial of argon plasma coagulation versus apc and apc and hemospray in the treatment of radiation proctitis

Conditions: Rectal Bleeding

Summary: randomized trial of argon plasma coagulation compared with argon plasma coagulation and hemospray in the therapy of bleeding from radiation proctitis

20 patients with radiation proctitis will be randomized to receive either argon plasma coagulation therapy alone or therapy with apc followed by hemospray administration ;the treatment in each arm is administered during a sigmoidoscopic examination

Eligibility criteria:
inclusion criteria: * bleeding from radiation proctitis exclusion criteria: * pregnancy bleeding diathesis

Keywords: radiation proctitis bleeding therapy
pain improvement after ultrasound guided continuous radio frequency 60 degree for plantar fasciitis

Conditions: Plantar Fascitis

Summary: detailed changes after ultrasound guided cry for plantar fasciitis in regard pain score and plantar fascia ap diameter in ultrasound scan pre and 30 days post operation


Eligibility criteria:
inclusion criteria: * chronic plantar fasciitis not responding to treatment not responding to classical injection exclusion criteria: * torn plantar fascia
transcranial direct current stimulation in clinical setting to reduce pain in older workers

Conditions: Chronic Pain; Aging

Summary: chronic pain is one of the main factors influencing workers' retention at work. considering that the prevalence of suffering from chronic pain increases with age, older workers are most likely to be absent from work because of their pain. transcranial direct current stimulation (tdcs) is a treatment option to reduce chronic pain. this study aims to document the effect of tdcs on pain and work retention in older workers and to compare the traditional tdcs protocol (5 sessions) with an enhanced protocol (11 sessions).

chronic pain affects many spheres of the lives of affected individuals and those around them. in canada, the prevalence of chronic pain is estimated at 15% of adults aged 18 and over. among seniors, the prevalence of this health problem can reach up to 50% and affect one in two seniors. chronic pain is one of the leading causes of work disability. in this context, pain reduction remains one of the most effective methods to enable the worker to stay at work. considering the aging quebec population, labor needs and the average retirement age which is increasingly postponed, it becomes crucial to take an interest in aging workers and their continued employment. transcranial direct current stimulation (tdcs) is a non-invasive neurostimulation method that has shown promise in reducing chronic pain. recently, several research teams have shown that tdcs has beneficial effects on pain, physical function and social participation in seniors. despite all these recent advances, very few studies have focused on optimizing tdcs treatment modalities and no studies have focused on the impact of tdcs on return to work or retention. the vast majority of studies using tdcs to reduce pain give one tdcs session per day for 5 consecutive days. this study aims to document the effect of tdcs on pain and work retention in older workers and to compare the traditional tdcs protocol (5 sessions) with an enhanced protocol (11 sessions).

Eligibility criteria:
inclusion criteria: * to be more than 55 years old * to have chronic pain * to have employment relationship * to have pain that interferes with work tasks exclusion criteria: - tdcs contraindications (epilepsy, metallic implant in the head, pacemaker, cochlear implant)

Keywords: transcranial direct current stimulation physical therapy work retention
chlortalidone and bumetanide in advanced chronic kidney disease: hebe-ckd trial

Conditions: Renal Insufficiency, Chronic

Summary: this study aims to demonstrate the possible benefit of a treatment based on double diuretic in patients with chronic kidney disease and severely impaired glomerular filtration rate. this is based on previous observations where the investigators found that volume overload is a frequent condition within this population and is strongly linked to an increase in morbidity and mortality. the investigators consider that this therapy could be beneficial given that most of these patients are treated with loop diuretics, however, with the passage of time, adaptive changes in the distal nephron occur that promote a decrease in the treatment effect. in this sense, thiazide diuretics at appropriate doses could 'break' the resistance, since their mechanism of action antagonizes the resistance mechanism. unfortunately, to this day, this treatment has not been fully evaluated. particularly in this type of population. the investigators developed a study proposed as a double blind randomized clinical trial, where the population will be divided into two groups. a group will be given the standard treatment based on loop diuretic (bumetanide), while the other group will receive the intervention (bumetanide plus chlorthalidone). after a 30-day follow-up period, the results will be measured. with respect to the effectiveness of the treatment, the decrease in volume overload by bioimpedance will be measured. while the occurrence of adverse effects during the same monitoring period will be observed.


Eligibility criteria:
inclusion criteria: * glomerular filtration rate less than 30 ml / min / 1.73m * without replacement therapy (dialysis or hemodialysis) * volume overload * at least 100 ml per day of residual diuresis * use of a loop diuretic for at least one month exclusion criteria: * allergies known to diuretics * patients with severe infections * patients with hemodynamic instability * amputees * patients with cognitive impairment * patients with acute renal failure * patients with graft loss

Keywords: diuretics bumetanide chlorthalidone chronic kidney disease volume overload
healthy kids & families: overcoming social, environmental and family barriers to childhood obesity prevention

Conditions: Obesity

Summary: the study will test the impact of a community health worker (chw)-delivered intervention aimed at helping families overcome barriers to childhood obesity prevention. barriers include social, environmental, and family issues. this intervention will be compared to a control condition consisting of a community health worker (chw)-delivered intervention aimed at helping families improve positive parenting skills.

the study will test the impact of a community health worker (chw)-delivered intervention aimed at helping families overcome barriers to childhood obesity prevention. barriers include social, environmental, and family issues. this intervention will be compared to a control condition consisting of a community health worker (chw)-delivered intervention aimed at helping families improve positive parenting skills. the intervention uses multiple delivery modalities to maintain novelty and prevent attrition/burden. these include home visits, telephone contacts, print (literacy sensitive newsletters), social media (facebook), and community events. parents and children will complete scheduled assessments at baseline, 6-, 12-, 18- and 24-month follow-up. the specific aims are: aim 1: to determine the effectiveness of the intervention compared to the control condition on child physical activity, healthy eating, bmi and utilization of built environment resources. aim 2: to determine the effectiveness of the intervention compared to the control condition on parent physical activity, healthy eating, bmi. aim 3: to examine the potential scalability of the intervention guided by the re-aim (reach effectiveness adoption implementation maintenance) model.

Eligibility criteria:
inclusion criteria: * eligible individuals for the research study are parents/guardians and their k-6th grade children attending one of 9 schools in the greater worcester area. parents and their children are recruited as parent-child dyads. exclusion criteria: * has an inability or unwillingness to give informed consent or assent * is a prisoner exclusion (child only) * the child has been told by a doctor that they cannot walk or eat fruits and vegetables.

Keywords: physical activity healthy eating weight families community health worker childhood obesity built environment
a study to evaluate the efficacy and safety of vb-201 in patients with covid-19

Conditions: Severe COVID-19

Summary: the purpose of this phase 2 study is to test safety, efficacy, and tolerability of an oral preparation of vb-201 in patients with severe covid-19


Eligibility criteria:
inclusion criteria: 1. signed and approved informed consent before initiation of protocol-specified procedures; 2. male or female subjects, ≥18 to ≤80 years of age with covid-19 3. sars-2-cov-2 infection confirmed by pcr in the last 8 days 4. hospitalized 5. symptoms of severe covid-19 as demonstrated by one of the following: * respiratory frequency \>30 breaths per minute * spo2 \<94% on room air at sea level * ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (pao2/fio2) \<300 mmhg * lung infiltrates \>50% 6. for a female subject; either: * subject is of non-childbearing potential, defined as: menopause with amenorrhea \>1 years, hysterectomy, or bilateral oopherectomy or * agrees to continue to use highly effective methods of birth control defined as those alone or in combination that result in a low failure rate (\<1%) when used consistently and correctly throughout the study and for at least one month following treatment termination and have a negative pregnancy test at screening and before the first dose of study drug; males must use at least one method of contraception (e.g. condom) throughout the study and for 90 days following the last dose of study drug; 7. in the opinion of the investigator, the subject will be compliant and have a high probability of completing the study and all required procedures. exclusion criteria: 1. evidence of critical covid-19 based on any of the following * admission to icu * assisted ventilation (invasive or non-invasive) * ecmo or hemofiltration required * ards * shock * acute cardiac failure 2. dementia 3. bacterial co-infection 4. co-infection with other common viral pneumonias (e.g. influenza) 5. participation in another interventional clinical trial or intention to participate in another interventional study during the course of this study; 6. in the opinion of the investigator, unlikely to survive for at least 48 hours from screening or anticipate mechanical ventilation within 48 hours 7. unable to take oral medication 8. history of gastrointestinal illness that may cause nausea and vomiting 9. subjects with any laboratory test at screening that common medical practice would deem as significantly abnormal. for example: * alanine transaminase (alt), aspartate transaminase (ast), or alkaline phosphatase \>5.0 times the upper limit of normal (uln) or * creatinine clearance \<30 ml/min 10. the subject has a known allergy or sensitivity to the study treatment or to any of the excipients contained in the study drug formulation (see list of ingredients in the investigator's brochure); 11. female subject with a positive pregnancy test or nursing, or planning a pregnancy during the course of the study; 12. unwilling or unable to comply with study requirements

Keywords: covid-19 severe
the impact of obesity on maternal and perinatal outcomes

Conditions: Obesity

Summary: body mass index is an index that is commonly used to classify underweight, overweight and obesity in adults. it is defined as the weight in kilograms divided by the square of the height in meters.the growing epidemic of obesity in our society has become a major public health issue where the proportion of overweight and obese among women aged 15-59 have increased from 68 percent in 2008 to 76 percent in 2015


Eligibility criteria:
inclusion criteria: * pregnant women * single fetus * gestational age \>28weeks exclusion criteria: * patient refusal * multifetal pregnancy * medical illness prior to pregnancy.
brief intervention to prevent alcohol socialization (bipas alcohol)

Conditions: Alcohol Drinking, Adolescent; Drinking Behavior; Drinking, Alcohol; Adolescent Behavior

Summary: early alcohol socialization occurs within the family. this multi-level, high-reach, low-intensity intervention to prevent early alcohol use capitalizes on the influence of providers, immunization timing, and pediatric guidelines that advise healthcare providers to give anticipatory guidance about early alcohol use. in conjunction, the intervention capitalizes on the power of technology to reinforce and expand upon pediatrician messages. the study seeks to understand the feasibility and effectiveness of a pilot intervention designed to prevent alcohol socialization through education of parents of rising 6th grade students.


Eligibility criteria:
inclusion criteria: * 18 years or older; * parent or guardian of an enrolled child at a study clinic; * cohabitate part time (2 days/week) or more with enrolled child; * be able to complete study activities in english; * be able to give informed consent; * own a phone with text message capabilities and access to internet. exclusion criteria: * families in which the 10-to-12-year old child is actively receiving treatment for alcohol use disorder.
sweat duct imaging in mother/newborn dyads

Conditions: X-Linked Hypohidrotic Ectodermal Dysplasia

Summary: the purpose of this study is to evaluate sweat duct number on the plantar surface of newborn infants using a non-invasive confocal microscopy device.

in this exploratory study, the investigators propose to evaluate sweat duct number on the plantar surface of newborn infants using a non-invasive confocal microscopy device (lucid vivascope®). this approach has the potential to be valuable in repeated sweat endpoint assessments, as the device was selected based on its ease of use, the low risk to patients of all ages, and its ability to generate quantitative data.

Eligibility criteria:
inclusion criteria: * healthy term newborns (37-42 weeks gestation at delivery) in the assessment nursery at barnes-jewish hospital, st. louis, mo * mother of a healthy term newborn who is enrolled in this study exclusion criteria: * congenital abnormalities affecting skin, nails, or hair in the newborn infant * family history of a sweating disorder
safety, pharmacokinetics, and antiviral activity of remdesivir in hospitalized children with rsv

Conditions: Respiratory Syncytial Virus (RSV)

Summary: thai-cares rsv study is a phase ii, open-label, multicenter, randomized controlled trial with a two-arm, parallel-group design. the study aims to assess the safety, efficacy, and acceptability of a five-day course of remdesivir in children under two years of age who are hospitalized with confirmed respiratory syncytial virus (rsv) infection, as determined by either a rapid antigen test or rt-pcr. the primary objectives include evaluating the treatment's safety profile, its ability to significantly reduce rsv replication, and its overall acceptance in this patient population.

an overall target of 120 participants will be involved in the study. eligible participants will be randomized (1:1) to receive arm 1: standard of care alone (control arm). arm 2: remdesivir in combination with the standard of care. remdesivir will be administered by intravenous infusion every 24 hours for five (5) consecutive days. each participant will be followed during hospitalization plus 7-10 days after day 6\* for final visit.

Eligibility criteria:
inclusion criteria: * signed informed consent from parents/caregivers * aged 0 to \<2 years * weighing at least 2.0 kg * onset of rsv associated-symptoms within 1 week of screening * confirmed\* with rsv infection (by rapid antigen test or rt pcr) * hospitalized children fulfilling at least two of the following three rsv disease severity criteria: * inadequate oral feeding * inadequate oxygen saturation (peripheral capillary oxygen saturation \[spo2\] \<95% on room air or requiring oxygen supplementation to maintain spo2 ≥95%) * signs of respiratory distress (respiratory rate of ≥60 breaths per min for children aged up to 1 year, or ≥40 breaths per min for those older than 1 year, or accessory respiratory muscles use \[subcostal, intercostal, or suprasternal retraction\], or both) exclusion criteria: * preterm infants (gestational age at birth less than 37 weeks) who are aged \<56 days * being hospitalized for other clinically relevant concurrent conditions (except for risk factors for severe rsv, e.g., cardiac disease, pulmonary disease, genetic disease, and prematurity) * concurrent treatments with other agents with actual or possible direct antiviral activity against rsv \<24 hours prior to study drug dosing (e.g. ribavirin) * alt or ast \> 5 × uln * egfr \<30 ml/min/1.73m2 using the schwartz formula if aged ≥1 year; or if aged \<1 year based on a creatinine value cut off dependent on chronological age * any major congenital renal anomaly if \<28 days * apgar score \< 5 when last recorded if age \<24 hours * known hypersensitivity to the study drug, the metabolites, or formulation excipient. * on renal replacement therapies (e.g., intermittent hemodialysis, peritoneal dialysis, continuous renal replacement therapy) * any condition that, in the opinion of the site investigator, would make participation in the study unsafe for the child, or comprise the study objectives

Keywords: respiration disorders rsv infection respiratory syncytial virus hospitalizations
influence of daylong glycemia on detraining induced metabolic changes

Conditions: Healthy

Summary: aim of the study is to investigate the impact of glycemic index (provided as soft drinks) on changes in insulin sensitivity, metabolic flexibility, and arterial stiffness in response to detraining. the investigators hypothesize that low glycemic soft drinks decrease the detraining-induced impairment of insulin sensitivity, metabolic flexibility and arterial stiffness.

the duration of the study is 7 weeks: two x 2 weeks intervention (phase a and phase b) with 3 weeks washout phase inbetween. each 2-week intervention phase consists of an active week followed by an inactive week. in phase a subjects consume high gi (maltodextrin and sucrose) soft drinks during the inactive week. in phase b subjects consume a low gi soft drink (palatinose) during the inactive week. subjects were randomly assigned to either start with phase a or with phase b (cross over design). during the whole study duration all food is provided (55% cho, 30% fat, 15% protein) physical activity will be assessed by a step counter (active phase 7000-10000 steps/d and inactive phase 3000-4000 steps/d).

Eligibility criteria:
inclusion criteria: * normal weight men, * age 18-35 y, * active life style, * \> 300 min sports/week exclusion criteria: * food allergies, * regular use of medication, * smoking, * chronic disease, * vegan/vegetarian diet

Keywords: glycemic index inactivity insulin sensitivity metabolic flexibility arterial stiffness young men
the influence of the ribs on the gravity of burst thoracic spine fractures

Conditions: Burst Thoracic Spine Fractures

Summary: the purpose of this study is to analyse the anatomic influence of the ribs related to the incidence and severity of burst spine fractures.

to analyse the anatomic influence of the ribs related to the incidence and severity of burst spine fractures, with the measurements of kyphosis, vertebral collapse and vertebral canal narrowing

Eligibility criteria:
inclusion criteria: * burst fractures in thoracic spine exclusion criteria: * fractures that were not burst fractures in thoracic spine

Keywords: spinal fractures thoracic vertebrae spinal canal kyphosis