Kornimate/medical-research-clean huggingface dataset:
stereotactic pelvic adjuvant radiation therapy in cancers of the uterus.

Conditions: Endometrioid Adenocarcinoma; Serous Carcinoma; Clear Cell Carcinoma; Carcinosarcoma; Dedifferentiated Carcinoma

Summary: advanced technology has enabled radiation oncologists to more accurately and precisely target radiation to areas at risk while maximally sparing healthy tissue. furthermore, there is growing evidence demonstrating both safety and efficacy for sbrt. we propose that these advantages are translatable to the adjuvant treatment of endometrial cancer. we submit that a prescription dose of 30 gy in 5 fractions, which equates to a 2 gy equivalent dose (i.e an eqd2) (α/β = 10 gy) of 48 gy, compares favorably to the eqd2 delivered standardly for adjuvant treatment (44.25 gy via 45gy/25fx; 50 gy at vaginal surface for vault brachytherapy) and therefore should be effective and safe dose in the adjuvant setting. through precision delivery and careful dosimetry the treatment should be safe and well tolerated with minimal impact on patient quality of life.


Eligibility criteria:
inclusion criteria: * patients, who have undergone hysterectomy for curative intent, with histologically confirmed endometrioid adenocarcinoma, serous or clear cell carcinoma, or carcinosarcoma or dedifferentiated carcinoma * patient is a candidate for adjuvant pelvic radiation (+/- vault brachytherapy), meeting one of the following conditions: * high grade histology or * outer-half myometrial invasion and figo grade 1-2 or * figo stage ii - iiic1 (all gross nodal disease must be resected) * patient is willing and able to give informed consent to participate in this clinical trial. * age ≥18 years. * patients who are to receive adjuvant systemic therapy in addition to pelvic radiotherapy will be eligible provided that there is at minimum a 3-week interval between any radiation treatment and chemotherapy treatments. adjuvant systemic therapy may be given before or after radiation treatment. * patient must be willing and able to complete the qlq-c30 questionnaire with en-24 companion as described in the study protocol. * primary language of the patient must be english or, if a patient's primary language is not english, they are still able to participate provided the qlq-c30 and en-24 is available in their primary language. exclusion criteria: * patient has had prior pelvic radiotherapy. * patient has received neo-adjuvant systemic therapy * patient has a contraindication to pelvic radiotherapy, such as but not limited to a connective tissue disease or inflammatory bowel disease. * patient has a contraindication to iodinated ct contrast. * patient has a hip prosthesis.
evaluating quality of life in patients with soft tissue sarcoma presenting with metastatic lung disease

Conditions: Soft Tissue Sarcoma; Metastatic Lung Disease

Summary: the purpose of this study is to evaluate the role of palliative surgery in improving quality of life (qol) and symptom control for patients who present with a soft tissue sarcoma (sts) and metastatic lung disease. responses to clinical edmonton symptom assessment system - sarcoma modified ( esas-sm) questionnaire for patients who have undergone surgery for resection of the primary tumour will be compared to those that are unable to have surgery. data collected from this questionnaire can highlight the benefits in patients' qol who receive palliative surgical resection, and whether these benefits surmount those who are not treated with palliative surgery.


Eligibility criteria:
inclusion criteria: * patients with soft tissue sarcoma with at least one pulmonary metastasis * metastatic lung disease must have been present at time of initial presentation exclusion criteria: * all patients under 18 will be excluded * patients who have been previously undergone surgical resection of the primary tumor

Keywords: non-surgical palliative surgery
natural course of initially metabolic healthy obese individuals (healthy obesity)?

Conditions: Healthy Obesity, Metabolically

Summary: the main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. therefore, the investigators want to understand: 1. what distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison? 2. which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?

the hypothesis is, that changes in the molecular regulation of adipose tissue as well as in adipose tissue cellular composition are responsible for the development of a rather metabolic healthy or unhealthy phenotype. knowledge of these factors will be used to generate new diagnostic concepts for personalized risk prediction and will furthermore serve as the basis to develop novel strategies to target adipose tissue to improve metabolic health.

Eligibility criteria:
inclusion criteria: * signed informed consent form * age between 18 and 60 years * bmi 30-50 kg/m2 * knowledge of german, which requires sufficient written and allow oral patient education inclusion criteria for initially healthy group * blood pressure \< 140/90 mmhg * normal glucose metabolism * hba1c \< 6.5 % * fasting glucose \< 7.0 mmol/l * normal lipid metabolism o ldl-cholesterol \< 5.0 mmol/l * ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference) * tg \> 1.7 mmol/l * hdl-cholesterol \> 1.0 mmol/l (male) / \> 1.3 mmol/l (female) * fasting glucose ≥ 5.6 mmol/l * bp ≥ 130/85 mmhg exclusion criteria: * pregnancy * medication and / or pathologies that prevent a safe execution of the fat tissue biopsies * history of or planned bariatric operation * medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases) * active malignant tumor (\<2a remission)

Keywords: obesity healthy
environmental treatment for seasonal affective disorder (sad)

Conditions: Seasonal Affective Disorder

Summary: the purpose is to study treatments of seasonal affective disorder (sad).

this is a multicenter, randomized controlled trial of negative ion generation versus light-emitting diode phototherapy for seasonal affective disorder. participants appropriate for the study are subjects with a dsm iv diagnosis of major depression, with seasonal pattern, winter type. subjects were seen at yale university,new haven,ct university of british columbia,vancouver,bc groningen university hospital,groningen, the netherlands, royal ottawa hospital, ottawa,ontario, mcgill university, montreal,quebec, university hospital,saskatoon, saskatchewan. the trial is 4 weeks in duration. this trial has now been completed.

Eligibility criteria:
inclusion criteria: * subjects meet dsm-iv criteria for major depressive episodes with a seasonal pattern, winter type. exclusion criteria: * significant suicidal risk * serious medical illness * pregnancy * other dsm-iv diagnoses * taking mood altering medication * may not travel to a sunny destination during study

Keywords: major depression seasonal affective disorder (sad)
study of recovery of strength after surgery comparing two different medications for reversal of muscle relaxant

Conditions: Surgery

Summary: the purpose of this study is to compare two different medications (neostigmine/glycopyrrolate and sugammadex) to see if one drug improves patient comfort regarding the return of muscle strength after surgery.


Eligibility criteria:
inclusion criteria: * adult patients age 18 years of age or greater who are capable of giving consent * undergoing surgical procedures of expected length 6 \</= hours requiring nmb exclusion criteria: * pregnancy * history of documented anaphylaxis or contraindication to any of the study medications * active coronary disease with a positive cardiac stress test * history of severe chronic obstructive pulmonary disease (copd) defined as an fev1 \< 50% of predicted * serum creatinine \>/= 2.0 mg/dl * severe hepatic dysfunction accompanied by coagulopathy * definition: * known liver disease and * inr \> 1.5 (except for patients on anticoagulants) and * platelet count \<100,00/ul without other obvious cause * chronic sustained release opioid for \> 2 weeks duration pre op (in the 30 days prior to surgery) * use of toremifene * significant cognitive impairment or documented psychologic impairment * myasthenia gravis or other neuromuscular disease * patients who are not eligible for standard anesthetic induction, eg, those needing rapid sequence induction or awake fiberoptic bronchial intubation. * american society of anesthesiologists (asa) status \> 3

Keywords: neuromuscular blockade sugammadex sug neostigmine neo/glyco 17-207
diabetic retinopathy and diabetic macular edema screening by non-physicians with limited training

Conditions: Diabetic Retinopathy

Summary: the purpose is to assess accuracy of digital retinal image interpretation by technicians and direct ophthalmoscopy by nurses for the determination of diabetic retinopathy severity and the presence of diabetic macular edema for the identification of referrals to ophthalmologists. the results of both screening methods were compared with comprehensive eye examination by ophthalmologists.

diabetic visual disabilities have increasingly become a global concern since a number of diabetic patients are expected to surge dramatically in the coming decade. essential means to minimize this problem are detecting vision-threatening diabetic retinopathy early in the course of disease and timely interventions by ophthalmologists. the american diabetes association had issued a guideline for the detection and recommended regular comprehensive eye examination as a preferred method. however, it is not likely that there will be ophthalmologists enough to comprehensively examine the surging number of diabetic patients. other practical screening methods, such as an interpretation of digital retinal images or direct ophthalmoscopy employed by other health care providers, for identifying the retinopathy for referral to ophthalmologists, should minimize this problem.

Eligibility criteria:
inclusion criteria: * diabetic patients defined by who criteria * lived in the geographic area of participated hospitals exclusion criteria: * have contraindications for receiving mydriatic medications * have ocular media not clear enough for making diagnosis by any of the screening equipment * have other retina diseases precluded the diagnosis of diabetic retinopathy
influence of combined double-bundle acl reconstruction with lateral retinacular release to prevent patellofemoral malalignment in isolated acl rupture

Conditions: ACL Injury

Summary: anterior knee pain which might be due to patellofemoral malalignment is an inevitable post operative complication after an acl reconstruction (aclr). we combined the double bundle aclr technique with lateral release technique to prevent patellofemoral malalignment post aclr.


Eligibility criteria:
inclusion criteria: * unilateral isolated total acl rupture * normal bmi exclusion criteria: * flexion contracture more than 200, presence of anterior knee pain before surgery, q angle \>140 in males and \>170 in females, presence of a patellar tilting, rupture of other ligaments, and muscular dysfunction.
effectiveness of pilates and taping in office workers with neck pain

Conditions: Neck Pain

Summary: the aim of this study is to investigate the effectiveness of pilates and kinesiotape applications in office workers with neck pain. in this direction, neck pain and disability, pain threshold, muscle strength, range of motion, core endurance, postural awareness and quality of life will be evaluated.

the aim of this randomized controlled experimental study was to investigate the effectiveness of pilates and kinesiotape in office workers with neck pain. in this study where a total of 42 office workers will be followed for 8 weeks, individuals will be randomly divided into two groups. the training groups will consist of 3 people each. the control group will receive only pilates training and the experimental group will receive kinesio taping in addition to pilates training. individuals will be analyzed for neck pain and disability, pain threshold, muscle strength, range of motion, core endurance, postural awareness and quality of life.

Eligibility criteria:
inclusion criteria: * have been office workers for at least 1 year * using a computer at a desk for at least 3 hours a day * having neck pain for more than 6 weeks * having neck pain rated at or above 3/10 on a visual analog scale exclusion criteria: * having neurological and rheumatologic chronic diseases * having received physical therapy in the last 6 months * having a history of trauma to the spine * having a history of surgery in the cervical spine * having diagnosed cervical/lumbar disc and spine pathologies * having an allergic reaction to taping

Keywords: neck pain office workers postural awareness quality of daily life range of motion
effect of a quality improvement initiative to address social determinants of health on rehospitalization rates in patients with heart failure

Conditions: Heart Failure

Summary: the objective of this program is to improve post-acute care coordination for necessary social services for patients leaving the hospital after recovering from an episode of decompensated heart failure.


Eligibility criteria:
inclusion criteria: * aged 18-99 years * resident of missouri or kansas * current inpatient admission for acute heart failure exclusion criteria: * under 18 years or over 99 years of age

Keywords: heart failure
a study to evaluate rapid throughput screening for human covid-19 infection

Conditions: Covid19

Summary: the purpose of this study is to assess the ability of an artificial intelligence smartphone-enabled point of care ecg to detect covid-19.


Eligibility criteria:
inclusion criteria: * adult males and females age 18 or greater. * undergoing covid-19 testing by pcr. * willing and able to provide informed consent. * pregnant females (minimal risk study, no risk from ecg). exclusion criteria: - unwilling or unable to provide informed consent.
laparoscopic single anastomosis sleeve ileal bypass versus laparoscopic sleeve gastrectomy for morbid obesity

Conditions: Obesity, Morbid

Summary: this study will compare two bariatric surgical interventions in terms of weight loss, gastroesophageal reflux, and effects on obesity-related comorbid conditions in morbidly obese patients.

sleeve gastrectomy is an established therapeutic option for morbidly obese patients without preexisting gastroesophageal reflux disease. the novel single anastomosis sleeve ileal bypass (sasi) procedure is already introduced in norway at a private high-volume bariatric hospital. the purpose of this study is to evaluate the effects of sasi in comparison to an established bariatric procedure, i.e. sleeve gastrectomy. the primary end point is 2-year changes in bmi after sleeve gastrectomy and sasi.

Eligibility criteria:
inclusion criteria: 1. morbid obesity at referral for bariatric surgery (i.e. a body-mass index \[bmi\] of ≥35 kg/m2 with obesity-related comorbid conditions or ≥40 kg/m2 with or without such comorbidities). 2. age 20-60 years. 3. previous failed attempts of weight loss. 4. norwegian speaking patients. exclusion criteria: 1. bmi ≥55 kg/m2. 2. a history of major abdominal or bariatric surgery (excluding appendectomy, cholecystectomy, and sectio). 3. established disabling cardiopulmonary disease, ongoing treatment for cancer, long-term steroid use, and conditions believed to be associated with poor adherence after surgery. 4. previous or current gastroesophageal reflux symptoms with daily use of antireflux medication. patients are also excluded if preoperative manometry identifies a hiatal hernia (≥4cm in axial length) or if preoperative upper endoscopy identifies esophagitis grade c or d (la classification), peptic stricture, barrett's esophagus, or esophageal carcinoma. 5. achalasia 6. pregnancy.

Keywords: procedure: sleeve gastrectomy bariatric surgery procedure: single anastomosis sleeve ileal bypass
partnership for a hispanic diabetes prevention program

Conditions: Diabetes; Pre-diabetes

Summary: the aims of the study are to investigate 1. the effects of an intervention vs. control on levels of glycosylated haemoglobin (haemoglobin a1c) in hispanic participants, older than 18 years, who have elevated ha1c at baseline (\>6.0%). glycosylated haemoglobin provides an indication of blood sugar levels over the past 3 months. elevated ha1c levels are seen in diabetics and pre-diabetics. 2. the effects of the intervention vs control on consumption of fresh fruit and vegetables 3. the effects of the intervention vs control on levels of physical activity


Eligibility criteria:
inclusion criteria: * aged 18 years and older * haemogloblin a1c ≥ 6.5% * hispanic ethnicity

Keywords: diabetes haemoglobin a1c hispanic behavioural intervention
a multi-center, parallel design, randomized, double-blind study to evaluate the safety and efficacy of 6 and 12 mg proellex® (telapristone acetate) administered orally in the treatment of premenopausal women with confirmed symptomatic uterine fibroids

Conditions: Uterine Fibroids

Summary: the primary objective of this study is to determine the safety and efficacy of two oral doses of proellex administered for up to 2 courses of treatment (18 weeks each), each separated by an off-drug interval (odi), to premenopausal women with symptomatic uterine fibroids.


Eligibility criteria:
inclusion criteria: * is a pre-menopausal female, between 18 and 47 years * participant has a history of at least 3 regular menstrual cycles in which menorrhagia (heavy bleeding) is due to uterine fibroids * confirmed uterine fibroid(s) at screening * visit 1 historical pictorial blood loss assessment chart of \>120 milliliters (ml) of blood loss, to ensure participants have a menstrual blood loss of at least 80 ml by alkaline hematin assay (during the baseline assessment period). * a body mass index (bmi) between 18 and 45 inclusive exclusion criteria: * participant is pregnant or lactating or is attempting or expecting to become pregnant during the entire study period * received an investigational drug in the 30 days prior to the screening for this study * has an intrauterine device in place * observation or history of abnormal endometrial biopsy including the presence of endometrial intraepithelial neoplasia * participants with abnormally high liver enzymes or liver disease
use of clarithromycin and rifabutin for the treatment of m. avium complex (mac) lung disease

Conditions: Mycobacterium Avium Complex Lung Disease

Summary: to determine the safety and tolerance of clarithromycin given three times per week in combination with multiple drugs including rifabutin three times per week

safety and tolerance of clarithromycin given 3 times weekly with multiple drugs including ethambutol and rifampin/rifabutin

Eligibility criteria:
inclusion criteria: * meet american thoracic society criteria for nontuberculous mycobacterial lung disease: two or more afb smear positive, culture positive sputums or bronchoscopic samples and/or two or more afb smear negative respiratory samples with moderate to heavy growth (2+-4+); abnormal cxr consistent with m. avium lung disease; absence of other potential mycobacterial or fungal lung pathogens (except for the coexistence of m. abscessus). * adults age 18 and older * pretreatment isolate of m. avium complex available for mic determination exclusion criteria: * history of allergy to study drugs * if a mensruating female, not pregnant and on adequate birth control. * children less than 18 years of age * hiv + or at high risk for hiv infection.

Keywords: mac
head circumference growth in children who develop multiple sclerosis later in life

Conditions: Multiple Sclerosis

Summary: multiple sclerosis patients commonly develop generalized ventricular dilation with or without cerebral atrophy over time. case studies in the literature have noted some multiple sclerosis patients develop the typical "normal pressure hydrocephalus" triad of dementia, gait disturbance and incontinence which were responsive to shunts. many patients with connective tissue disorders (ehlers-danlos syndrome) develop multiple sclerosis and studies indicate that in the multiple sclerosis population, there exists over 10% more ehlers-danlos patients than in the normal population. because studies are indicating a form of external communicating hydrocephalus in the ehlers-danlos population, the author hypothesizes the same type of hydrocephalus may occur in the multiple sclerosis population. to evaluate this hypothesis, investigators will retroactively evaluate the head circumference of multiple sclerosis patients between birth and 15 months (before the skull sutures have closed).

multiple sclerosis patients commonly develop generalized ventricular dilation with or without cerebral atrophy over time. case studies in the literature have noted some multiple sclerosis patients develop the typical "normal pressure hydrocephalus" triad of dementia, gait disturbance and incontinence which were responsive to shunts. many patients with connective tissue disorders (ehlers-danlos syndrome) develop multiple sclerosis and studies indicate that in the multiple sclerosis population, there exists over 10% more ehlers-danlos patients than in the normal population. because studies are indicating a form of external communicating hydrocephalus in the ehlers-danlos population, the author hypothesizes the same type of hydrocephalus may occur in the multiple sclerosis population. to evaluate this hypothesis, investigators will retroactively evaluate the head circumference of multiple sclerosis patients between birth and 15 months (before the skull sutures have closed). high pressure on the brain (even if subtle) could be evidence of congenital ccsvi (cerebrospinal venous insufficiency), increased cerebrospinal fluid (csf) production, the poor drainage of cerebral spinal fluid, or a combination of all. retrospective examination of skull expansion is a necessary step to ascertain these possibilities, allowing for early treatment and the hope of avoidance of the neurological symptoms, and often disabling effects. it is the author's belief that "benign external hydrocephalus" is not a benign condition.

Eligibility criteria:
inclusion criteria: * diagnosis of multiple sclerosis exclusion criteria: * excludes cis (clinically isolated syndrome)

Keywords: multiple sclerosis hydrocephalus
patient compliance during pegintron and rebetol combination therapy in chronic hepatitis c (study p04690)

Conditions: Hepatitis C, Chronic; Hepatitis C

Summary: participants will receive pegintron injection pen (peginterferon alfa-2b) and rebetol (ribavirin) combination therapy as their usual medical treatment. the current study aims to evaluate whether the previously introduced, and now widely accepted and implemented educational program, which represents additional efforts in everyday practice to increase patient compliance, will succeed in achieving adherence rate in treated participants similar to the extent demonstrated by clinical trials.


Eligibility criteria:
inclusion criteria: * before inclusion, all participants must be informed and must give consent for the use of his/her anonymized health data related to his/her treatment with peginterferon alfa-2b (injection pen) and ribavirin. exclusion criteria: * according to peginterferon alfa-2b/ribavirin label.