Kornimate/medical-research-clean huggingface dataset:
decolonization efficacy of polyhexanide vs. mupirocin

Conditions: Staphylococcus Aureus; Colonization, Asymptomatic

Summary: this pilot randomized controlled trial evaluates the feasibility, tolerability, and preliminary efficacy of a decolonization regimen using polyhexanide in reducing staphylococcus aureus colonization in the preoperative phase of elective spine surgery, compared to the standard mupirocin and chlorhexidine regimen. the trial involves 24 participants randomized into two groups: one receiving polyhexanide and the other receiving mupirocin and chlorhexidine. the primary outcome is the randomization rate, with secondary outcomes including other feasibility outcomes, tolerability, and efficacy measures such as the reduction in s. aureus colony-forming units (cfus) and changes in the nasal and skin microbiome composition.


Eligibility criteria:
inclusion criteria: * age over 18 years * scheduled for elective spinal surgery * colonized with staphylococcus aureus * informed consent provided exclusion criteria: * emergency spine surgery * methicillin-resistant staphylococcus aureus (mrsa) or mupirocin-resistant s. aureus * known allergies to products used in the trial * pregnant or breastfeeding women * recent antibiotic therapy (within 14 days) * known non-compliance, substance abuse, or psychological disorders * participation in another antimicrobial trial within the last 30 days

Keywords: staphylococcus aureus colonization spinal surgery decolonization
efficacy and safety of irlanda-1-association on the treatment of common cold in children

Conditions: Common Cold

Summary: the purpose of this study is to evaluate the clinical efficacy of the drug associations in the treatment of common cold symptoms.

double-blind,randomized, multicenter; maximal experiment duration: 7 days; 03 visits; safety and efficacy evaluation.

Eligibility criteria:
inclusion criteria: * participant within 48 hours of the onset of common cold symptoms: headache, sneezing, sore throat, nasal obstruction, cough, coryza and body pain; * signed consent of the patient; * participant whose tutors have the capacity to understand and consent to the child's participation in the clinical study, manifested by signing tcle exclusion criteria: * patients with any clinically significant disease that in the investigator is opinion can´t participate in the study; * patients with any laboratory finding or image finding that in the investigator is opinion can´t participate in the clinical trial; * patients with history of hypersensitivity to any of the formula compounds; * participation in clinical trial in the year prior to this study; * patients with vaccine reaction; * patients who have uncontrolled asthma however, participants in use of pulmonary corticosteroids (alone or in combination with other products) will be allowed if they are in stable dose and diagnosed with controlled asthma; * patients with gastroesophageal reflux, gastric or duodenal ulcer or other serious disease of the gastrointestinal tract; * patients with diabetes mellitus type i and ii; * pregnancy or risk of pregnancy and lactating patients; * patients who were in use of drugs that can interfere with flu symptoms evaluation.
emergency department mcg for suspected acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: the goal of this study is to assess a new non-invasive computerized, multiphase, resting electrocardiogram analysis device in early identification of patients at risk for acute coronary syndrome. the overall objective is to assess the association between the results from a resting mcg and 30-day cardiovascular outcome in patients presenting to the emergency department with suspected coronary disease.


Eligibility criteria:
inclusion criteria: * age 18 and over. * symptoms consistent with a possible acute coronary syndrome per the treating emergency physician. * has an electrocardiogram performed while in the ed. exclusion criteria: * acute st-segment elevation mi. * patient unable or unwilling to complete follow-up.
the use of an open label placebo to treat cancer related fatigue in cancer survivors

Conditions: Fatigue

Summary: the purpose of this randomized-controlled, crossover pilot trial is to evaluate the feasibility, acceptability and effects of a non-deceptive (open-label) administration of placebo pills for treating cancer related fatigue (crf). if significant effects are found, the investigators will later determine if the presence of a comt val18met genotype variant predicts placebo responses.

the investigators will conduct a pilot randomized-controlled, crossover trial to evaluate the feasibility, acceptability and effect of the open-label administration of placebo pills on crf and associated psychosocial factors (e.g., emotional health, social health, quality of life, etc.) for cancer survivors (css) who have completed all cancer treatments yet continue to experience crf. additionally, in an exploratory manner, the investigators will collect dna saliva specimens that will be analyzed for potential biomarkers that may predict placebo responses. to do this, investigators will use a 7-week, single site, two-parallel arm, randomized controlled crossover pilot study to determine the feasibility, acceptability and effects of an open label placebo intervention (olpi) on css who completed cancer treatments at least 6 months prior to enrollment in the study and report a fatigue score of 4 or greater on a 0-10 scale. investigators will enroll 80 eligible cs participants who will be randomized into two groups of 40 (group1 and group2 ). in this crossover study, participants in group1, will receive an olp (placebo pill) for 21-days (period 1)and group2 (observational controls) will not. after a 1-week washout period, group2 will receive the olp for 21-days (period 2) and group1 (observational controls) will not.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of stage ii - iv cancer; * completed primary treatment 6months to 10 years; * report ≥4 (moderate fatigue) on a 0-10 fatigue severity rating scale; * agree not to change any medications or treatments during the study; * willingness to make 4 clinical site visits over the course of the 49-day study. exclusion criteria: * stage 1 cancer; * uncontrolled diabetes; * uncontrolled copd; * uncontrolled ischemic heart disease; * uncontrolled liver/kidney diseases; * uncontrolled autoimmune diseases; * uncontrolled psychiatric or cognitive diseases.

Keywords: cancer-related fatigue
s.l. spray solution® and difflam® and acular®spray for the prevention of postoperative sore throat

Conditions: Sore Throat

Summary: the purpose of intubation for patients under general anesthesia is to maintain their respiratory function. however, this procedure does cause a postoperative sore throat. comfort of patients could be promoted if effective treatment could be found. the specific aims of this project are: 1. comparing the efficacies between the spray of s.l. spray solution and difflam to release postoperative sore throat. 2. acular spray for the prevention of postoperative sore throat. 3. comparing the efficacies between the spray of s.l. spray solution and difflam and acular to release postoperative sore throat.

this is a quasi-experimental study with purposive sampling. patients were distributed into the four groups (1.5mg / ml benzydamine hydrochloride, 3.0mg / ml benzydamine hydrochloride, 5％ketorolac tromethamine) by the operative room. research tools including pain scale (numeric rating scale: 0-10), drugs and case data record sheet. collected information was managed by spss for windows (version 21.0) statistical software package. both the descriptive and inferential statistics were performed. sample homogeneity among the four groups were verified by f-test and chi-square test. generalized estimating equation was selected to compare the throat pain in the four points of assessment. the specific aims of this project are: 1. comparing the efficacies between the spray of s.l. spray solution and difflam to release postoperative sore throat. 2. acular spray for the prevention of postoperative sore throat. 3. comparing the efficacies between the spray of s.l. spray solution and difflam and acular to release postoperative sore throat.

Eligibility criteria:
inclusion criteria: 1. intubation for patients under general anesthesia 2. age\>20 3. none pre-operative sore throat 4. by the researchers explain research purposes, the researchers agreed to participate exclusion criteria: 1. postoperative on n-g tube 2. surgical side is located by the mouth or throat 3. thyroidectomy 4. difficult airway 5. none extubation at pacu 6. on patient-controlled analgesia 7. the medical records have a history of nonsteroidal antiinflammatory drugs allergy 8. medical records have kidney disease or a history of renal dysfunction 9. peptic ulcer 10. pregnancy or lactation

Keywords: postoperative sore throat american society of anesthesiologists status general anesthesia post-anesthesia care unit(pacu)
study on visual performance of a monofocal intraocular lens

Conditions: Cataract Senile

Summary: retrospective/prospective study on visual performance of a monofocal intraocular lens (iol). the objective is to compare best corrected distance visual acuity (cdva) between 1-3-month and 12- month follow-up.


Eligibility criteria:
inclusion criteria: * age 18 years or older; * patients with monolateral or bilateral (only one eye will be the study eye) monofocal iol implantation after uncomplicated surgery in the period between may 2019 and november 2019, if the follow-up visit can be performed 10-18 months after surgery; * no visual acuity limiting pathologies; * availability of 1-3-month postoperative data * availability, willingness and sufficient cognitive awareness to comply with examination procedures in case of a prospective 12-month visit; * written informed consent for participation in the study and data protection. exclusion criteria: * difficulty for cooperation (distance from their home, general health conditions) * subjects with diagnosed degenerative visual disorders (e.g. macular degeneration or other retinal or optic disorders) that would confound visual acuity measurements; * subjects with surgical complications or secondary interventions (except for nd:yag capsulotomy) related to the cataract surgery of the monofocal iol eye(s) or any other interventions in the post-operative eye including but not limited to glaucoma surgery, retinal surgery; * visual field loss which has impact on visual acuity; * use of systemic or ocular medication that might affect vision; * patients with amblyopia, strabismus, forme fruste keratoconus or keratoconus; * capsular or zonular abnormalities that have affected postoperative centration or tilt of the lens (e.g. pseudoexfoliation syndrome); * concurrent participation in another device investigation.
neurofeedback training for dyslexia

Conditions: Dyslexia; Reading Problem

Summary: the study aims at testing a neurofeedback (nf) training specifically designed for inducing a functional hemispheric imbalance of the tempo-parietal regions in individuals with dyslexia. a randomized clinical trial aimed at comparing two experimental conditions is described: a) left theta/beta nf training in combination with right beta/theta nf training and b) sham nf training.


Eligibility criteria:
inclusion criteria: * diagnosis of dyslexia or reading performance 2 sd below the norm * average intelligence exclusion criteria: * psychiatric conditions * comorbidity with neurodevelopmental disorders * neurological disorders * epilepsy * enrollment in linguistic or literature university courses
her2 circulating tumor cells in gastric cancer

Conditions: Gastric Cancer

Summary: the investigators propose to survey the frequency of her2 (+) ctc in order to lay groundwork for future clinical trials incorporating her-2 targeted agents in gastric cancer.

we propose to survey the frequency of her2 (+) ctc in order to lay groundwork for future clinical trials incorporating her-2 targeted agents in gastric cancer. blood samples will be collected from metastatic gastric cancer patients.

Eligibility criteria:
inclusion criteria: * patients older than 18 years ② patients with localized, histologically confirmed gastric cancer ③ informed consent form exclusion criteria: * no informed consent form
a study on safety and efficacy of propofol in small children under 2 years of age

Conditions: Heart Rate Low; Anesthesia; Functional

Summary: this retrospective study the safety and efficacy of intravenous propofol used in children under 2 years of age during general anesthesia for surgery.

emr review of intravenous propofol used in target controlled infusion method in children under 2 years old.

Eligibility criteria:
inclusion criteria: * children under 2 years of age * children who received intravenous propofol for maintenance of anesthesia exclusion criteria: * children who underwent general anesthesia with inhalational anesthetics
radiotherapy alternates human epidermal growth factor 2 (her2) expression in human breast cancer

Conditions: Human Epidermal Growth Factor 2 Negative Carcinoma of Breast

Summary: based on fundamental study （in vitro and in vivo, pro. jianjian li）， her2 expression would be changed from negative to positive by cancer irradiation with liner-accelerator at dose 6gy or up. the propose of this study is to reveal the irradiation result on her2 expression in human breast cancer.


Eligibility criteria:
inclusion criteria: * histological confirmed advanced breast cancer * cancer sample can be obtained by fine needle biopsy * ihc and fish confirmed her2 negative * radiotherapy indication for local residual cancer exclusion criteria: * no radiotherapy indication * patient refuse

Keywords: breast cancer human epidermal growth factor 2 (her2) irradiation
does parathyroid autofluorescence reduces unintensional parathyroidectomy during total thyroidectomy with central lymph node compartment dissection

Conditions: Thyroid Cancer; Thyroidectomy with Central Lymph Node Dissection

Summary: the aim of the study is to evaluate the effectiveness of autofluorescence in the intraoperative preservation of parathyroids during total thyroidectomy with central lymph node compartment dissection.

real-time intraoperative identification and functional maintenance of structures are of major importance in endocrine surgery, with a critical role in clinical outcomes and patients' quality of life. despite the advances in preoperative imaging techniques, there is still need for precise intraoperative visualizing \[1\]. limitations of naked eye inspection and subjectivity of palpation are imposing challenges even for the most experienced surgeons \[1-3\]. nowadays, attention is attracted to intraoperative imaging techniques using near infrared fluorescence (nirf) with endogenous or exogenous contrast agents. these imaging techniques are attractive in biomedicine due to its high penetration depth and low scattering in human tissue \[2\]. autofluorescence is the ability of several natural substances or drugs to be fluorescent after the absorbance of light or radiation. it has been already proved that parathyroid glands emit their own light after near-infrared (nir) around 820nm , providing high contrast to the surrounding tissues. this made near-infrared autofluorescence a potential useful tool in hands of experienced endocrine surgeons in order to distinguish parathyroid glands from other anatomic structures during thyroidectomies. approximately 7.6% of thyroid surgeries resulted in hypoparathyroidism, with 75% of these cases being transient and 25% being chronic. the mechanisms that underlie hypopth are related to disruption of parathyroid arterial supply or venous drainage, mechanical injury, thermal or electrical injury, and either intentional or inadvertent partial or complete removal. the aim of the present study is to evaluate the value of intra-operative autofluorescence imaging concerning the unintentional excision rate of parathyroids during total thyroidectomy with central lymph node compartment dissection. moreover, we are going to evaluate correlation of autofluorescence with 24 hours post-operative pth.

Eligibility criteria:
inclusion criteria: 1. patient is over 18 years old 2. patient scheduled for a non-emergency operation 3. patient eligible for total thyroidectomy exclusion criteria: 1. patient is participating in another clinical trial which may affect this study's outcomes 2. prior operation in the neck 3. primary or secondary hyperparathyroidism 4. vitamin d deficiency 5. use of drugs that influences calcium metabolism (vitamin d analogues, oral calcium supplements, bisphosphonates, teriparatide, thiazide diuretics, aromatase inhibitors)

Keywords: thyroidectomy central lymph node compartment dissection autofluorescence fluobeam xs
effect of non-invasive ventilation in cystic fibrosis patient with chronic respiratory failure.

Conditions: Cystic Fibrosis; Chronic Respiratory Failure

Summary: there is no randomised controlled trials to determine the clinical effects of long term non-invasive ventilation in cystic fibrosis patients.

the effects of long term mechanical ventilation for the treatment of respiratory failure in patients with neuromuscular diseases is well established. long term non-invasive ventilation is commonly used in the treatment of cystic fibrosis patients with respiratory failure. however, the benefits of this treatment have never been studied in randomized control trials and are unknown. the goal of this multicenter study is to evaluate the effects of the addition of non-invasive ventilation to the standard therapy in stable cystic fibrosis patients with chronic hypercapnia. two groups of patients will be followed: the first group will receive standard treatment for advanced cystic fibrosis according to international guidelines, the second group will receive the same treatment plus non-invasive ventilation (4h/day). the follow up time will be one year for each patient.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cystic fibrosis * chronic hypercapnia on room air in stable condition (paco2 between 45 and 55mmhg in two occasions separated by more than 4 weeks) * informed consent exclusion criteria: * current treatment with non-invasive ventilation * paco2 more than 55 mmhg * recent pneumothorax (within past 3 months)

Keywords: hypercapnia non-invasive ventilation
the influence of gonadal hormone suppression on adipocyte lineage and the microbiome

Conditions: Adipose Tissue; Microbiome; Menopause

Summary: this research study plans to learn more about the role of female sex hormones on adipose tissue (or fat) and the gut microbiome (or the organisms that are in your digestive tract). the rationale for this study is that the rate at which women gain fat (especially in the stomach region) increases after menopause. it is thought to be due to the loss of estrogen because post-menopausal women who take estrogen gain less weight than those who do not take estrogen. gut bacteria process estrogen and help determine the types of estrogen that circulate in the body. these bacteria can be changed with lifestyle factors such as diet, and may therefore, also affect the risk of diseases that are more common in women after menopause i.e., cardiovascular disease and cancer. in this study the investigators will obtain fat biopsies before and after 6 months of ovarian hormone suppression to measure how the fat cells change with the loss of female sex hormones (e.g., medical menopause). the investigators will also obtain stool and urine samples before and every month during the study to measure changes in the microbiome.


Eligibility criteria:
inclusion criteria: * enrollment into the parent protocol (comirb 16-1479 - the impact of estrogen status on the biological function of brown adipose tissue in women measured using quantitative pet/ct; pi - edward melanson, phd) * participation in gnrhag intervention exclusion criteria: * known allergy to lidocaine or other numbing medication * uncontrolled bleeding disorder or inability to withhold aspirin/nsaids or other blood thinning medications for 7 days prior to biopsy procedure.
inverting grayscale improves detection of proximal femur fracture

Conditions: Diagnoses Disease

Summary: proximal femur fractures (pff) are a worldwide public health concern. a delay in the diagnosis and treatment worsens the prognosis. inversion of grayscale is a tool available on most x-rays visualization software, and its use has been suggested to improve radiological diagnosis. the study aims to determine if using inverted grayscale radiography results in better diagnoses of pff among medical students. material and methods. the investigators evaluated the detection of pff by fifth-year medical students on a series of 30 pelvis x-rays. the series was composed of 20 x-rays with pff and 10 x-rays without fracture. a first reading session was set up where x-rays were presented separately in conventional and inverted grayscale. a second session one month later showed both grayscale visualizations together (bicontrast x-rays analysis method - bixam). x-rays' order of appearance was randomized. the investigators performed the same evaluation on senior orthopedic surgeons as a control. finally, sensitivity, specificity, and accuracy were assessed for each method (conventional, inverted, and bixam) with the mcnemar test. subgroup analyses were performed on the fracture localization (femoral neck, trochanteric).


Eligibility criteria:
inclusion criteria: * fifth-year medical students exclusion criteria: * other medical students
study of the impact of changes in carbonemia on microcirculation in patients achieving a test hypercapnia

Conditions: Microcirculation; Blood Circulation

Summary: the microcirculatory alterations is common in circulatory failure, especially during sepsis. the severity of these changes and their sustainability are responsible of multi organ failure and ultimately death. the optimization of microcirculatory flow could be a central objective of the management of patients hospitalized in intensive care. microcirculation includes all blood vessels of a diameter smaller than 100 micrometer. it represents the largest heat exchange surface of the body and is involved in tissue oxygenation. microcirculatory flow is conditioned by the macrocirculation (heart rate and blood pressure) and the state of the microcirculation (thrombosis, vasoconstriction ...). the role of the co2 in regulating microcirculatory flow is little studied. a recent work of our team and the oldest work in the literature lead to believe that co2 has a specific role in modulating microcirculatory flow. no study to date precisely studied the impact of changes in the microcirculatory flow carbonemia . the hypocapnia test is carried out in a standardized manner by inhalation of a mixture enriched in co2 7% allows a significant increase in carbonemia. hypocapnia will in turn obtained by a calibrated voluntary hyperventilation test. direct visualization of microcirculation by confocal microscopy is now considered the gold standard for exploring the microcirculation.


Eligibility criteria:
inclusion criteria: * patients from achieving hypercapnia test the chu of saint-etienne * non smoking * non diabetic * affiliated with or entitled to a social security system * written consent exclusion criteria: * subjects not performing the test hypercapnia in full * patients with dermatological pathology at the study area * patient with raynaud's syndrome * patients with known bleeding disorders * refusal to consent

Keywords: microcirculation confocal microscopy hypocapnia