Kornimate/medical-research-clean huggingface dataset:
clinical relevance of the salvage treatment for colorectal neuroendocrine tumors

Conditions: Rectal Neoplasms; Neuroendocrine Tumors

Summary: we evaluated all related clinical and pathologic data of rectal net cases, including the resection margin status, net grading, and lymphovascular invasion status. finally, the present study was aimed at (1) determining the risk factors for ln and distant metastases in colorectal nets (2) clarifying the clinical significance of the salvage treatment for colorectal neuroendocrine tumors following initial endoscopic resection with positive resection margin status and (3) compare different salvage treatment of this uncommon disease through conducting a large, multi-center cohort study.


Eligibility criteria:
inclusion criteria: * within the age range of 18 to 65 years, diagnosed with rectal neuroendocrine tumors. furthermore, patients were required to have a palpable tumor as determined by digital rectal examination or accessible through proctoscopy, with the distal border situated within 12 cm from the anal verge. exclusion criteria: * (1) muscularis propria invasion or net grading = 3, (2)regional ln or distant organs metastasis at the time of diagnosis, (3) incomplete follow-up information, (4) the patient had multiple primary tumors, (5) patients with surgical excision or inappropriate methods such as forceps removal, and (6) the patient had a history of malignant tumors.

Keywords: endoscopic resection
surgical removal of visceral fat tissue (omentectomy) associated to bariatric surgery: effects on insulin sensitivity

Conditions: Insulin Resistance; Obesity; Metabolic Syndrome X

Summary: the intraabdominal fat is associated with insulin resistance, a condition that is in the basis of diabetes, metabolic syndrome and some cardiovascular diseases. it is not clear whether it is the origin of it or a surrogate marker only. we intend to compare the effects of bariatric surgery with versus without omentectomy in morbidly obese people intended to go through bariatric surgery, accessing insulin sensitivity by metabolic tests. if the visceral fat is causative of insulin resistance, its surgical removal (omentectomy) might lead to improvement of insulin action, as seen in animal studies and in one study with morbidly obese human volunteers.

in order to verify a potential additional benefit of omentectomy combined to roux-en-y silastic ring gastric bypass, insulin sensitivity will be studied by the gold-standard test, euglycemic-hyperinsulinemic clamp, since early postoperative follow-up (before significant weight variation), compared to a control group of bariatric surgery (same technique) alone. the variables will be analyzed in the post surgical evolution for correlation to metabolic changes: adiposity-related hormones and cytokines; lipid profile and other cardiovascular risk factors; molecular expression of biopsied subcutaneous adipocytes in vitro; anthropometrics; ultrasonography of abdominal subcutaneous and intra-abdominal fat depots and carotid intima-media thickness (preclinical atherosclerosis evaluation).

Eligibility criteria:
inclusion criteria: * age between 21 and 50 years. * female sex. * bmi between 40 and 50kg/m2. * metabolic syndrome (ncep/atp iii criteria). exclusion criteria: * weight variation \>5% within 3 months prior to preoperative tests. * use of antidiabetic medications within 3 months prior to preoperative tests. * hba1c \>8%. * use of systemic corticosteroids for longer than 1 week within 3 months prior to preoperative tests. * hepatic cirrhosis, renal failure or any clinical condition (other than obesity) recognized as impairing insulin sensitivity. * present smoking.

Keywords: insulin resistance metabolic syndrome x obesity intra-abdominal fat omentum bariatric surgery glucose clamp technique intravenous glucose tolerance test adiponectin cytokines
efficacy and safety of bifidobacterium combined with high-frequency transcranial magnetic stimulation in the treatment of adolescent depression

Conditions: Adolescent Depression

Summary: a total of 100 patients with adolescent depression who were admitted to our hospital between march 2022 and october 2022 were selected. on the basis of double blinding, these patients were randomly divided into the observation group(n=50) and the control group(n=50) using a random number table. 5s management method was used in the whole process of treatment to improve the hospital environment, increase the work efficiency and reduce the occurrence of cross infection through the effective implementation of the five steps of sort(seiri), set in order(seiton), shine (seiso), standardize(seiketsu) and sustain(shitsuke).


Eligibility criteria:
inclusion criteria: * aged 13-18 years old; * met the diagnostic criteria for depression in the international classification of disease-10 (icd-10); * with a total score of the hamilton rating scale for depression (hamd-24) ≥20 in the initial assessment; * who were right-handed exclusion criteria: * with a definite diagnosis of other mental disorders in the past; * with a past or current history of manic episodes; * with a past or current history of severe physical diseases; * who used antidepressants, mood stabilizers, steroids, anti-inflammatory drugs, antibiotics, and immunomodulators in the past 1 month; * who used lactic acid bacteria products for ≥7 days in the past 1 month; * with a history of alcohol or psychoactive substance abuse within the last 3 months; * with contraindications for rtms, including but not limited to intracranial metal foreign bodies, cardiac pacemakers, and ear hearing aids; * complicated with organic brain diseases, epileptic diseases, and severe physical diseases
intrapleural docetaxel administration using medical pleuroscopy in malignant effusion with lung cancer

Conditions: Pleural Effusion, Malignant; Non-small Cell Carcinoma

Summary: in this trial, the effect of intrapleural docetaxel administration using medical pleuroscopywill be evaluated in lung cancer patient with malignant effusion.

this study is designed to be pilot, single-center, open-label, single-arm, prospective, phase ii trial of patient with nsclc with pleurla effusion. approximately 40 patients will be enrolled into the trial, and study will be performed to 31dec2018 from irb and korea: mfds approval date. docetaxel will be administed to interpleural space using medical pleuroscopy in malignant effusion with lung cancer. response evaluation will be done until confiramtion of disease progression.

Eligibility criteria:
inclusion criteria: * age ≥ 20, and nsclc patients with malignant pleural effusion and related symptoms * ecog ≤ 2 * blood test anc≥ 1500/mm3, hb ≥ 8.0g/dl, platelet count ≥ 100000/mm3 serum creatinine ≤ 1.8mg/dl, total bilirubin within normal limits, transaminases ≤ 1.5 x unl, alkaline phosphatase ≤ 2.5 x unl bun ≤ 25mg/dl, creatinine clearance ≥ 50ml/min * negative serum or urine pregnancy test for women for childbearing age * patients who provide written informed consent for the study exclusion criteria: * age \< 20 * patients who were previously perfomed pleurodesis * patients who were previously treated with thoracic radiosurgery * patinet with bilateral pleural effusion * age ≥ 80yrs * patients with histories of hypersensitivity to docetaxel * patients with cardiovascular, respiratory, hepatic, renal, gastrointestinal, neunological disease, asthma, mi, stroke, arrhythmia, uncontrolled hypertionsion, etc. that would effect absorption, distribution, and metabolism of ip or be risk factors during ip administrion. * patients who could not understand the study procedure

Keywords: pleurodesis
the oxylipin response as a new predictive biomarker of patient responsiveness to biotherapy in rheumatoid arthritis (opera)

Conditions: Rheumatoid Arthritis

Summary: opera aims to better understand and predict the responsiveness of rheumatoid arthrits (ra) patients to biological disease modifying anti-rheumatic drugs (bdmards). our objectives will be (i) to determine, at baseline, the differences of oxylipin response between responders vs non-responders to anti-tumor necrosis factor (anti tnf) and (ii) to investigate the relationships between the oxylipin response, the polyunsatured fatty acid (pufa) content of immune cells and the cytokine response.

30 ra patients starting an anti-tnf will be recruited. before and after 6-months of anti-tnf treatment, blood will be collected using the truculture system (2x 1ml in non-stimulated and lipopolysaccharide (lps)-stimulated truculture tubes) to measure whole blood oxylipin response (wbor), cytokine response, pufa cell content and gene expression under homeostatic and stimulated conditions (i.e. lps). at baseline and after 6 months of treatment, the rheumatologist will perform a clinical evaluation of their ra patients using disease activity score using 28 joint-count (das28-crp). non-responders will be defined as ra patients failing to achieve good or moderate eular response after 6 month of anti-tnf treatment, discontinued the drug, initiated a new bdmard, or increased dosage of oral corticosteroids greater than 10 mg/d at the second visit.

Eligibility criteria:
inclusion criteria: * rheumatoid patient according to acr-eular (american college of rheumatology-european league against rheumatism) 2010 criteria, * active disease defined by a das28-crp\>3.2, * biological and targeted synthetic dmards naïve, * indication for treatment with anti-tnf * stable corticosteroid therapy ≤ 10 mg/day exclusion criteria: * contra-indications to a biological dmards (current or recent cancer, active infection), * non-steroidal anti-inflammatory drugs (nsaids) treatment during the last 2 weeks before inclusion

Keywords: anti tnf oxylipin cytokine polyunsatured fatty acid
heparins for thromboprophylaxis in covid-19 patients: hethico study in veneto

Conditions: COVID-19; Hypercoagulability

Summary: the hethico study aims to collect retrospectively documented clinical information on patients hospitalized in veneto region (italy) for sars-covid-2 infection in 2 types of settings, medical environment (coorte med), and intensive / sub-intensive (coorte icu), to assess the safety and possible efficacy of the anticoagulant treatments used for thromboprophylaxis, or in preventing thrombotic complications related to hospitalization from covid-19.

the hethico study aims to collect retrospectively documented clinical information on patients hospitalized in veneto region (italy) for sars-covid-2 infection in 2 types of settings, medical environment (coorte med), and intensive / sub-intensive (coorte icu), to assess the safety and possible efficacy of the anticoagulant treatments used for thromboprophylaxis, or in preventing thrombotic complications related to hospitalization from covid-19. furthermore, the possible association between the observed clinical evolution and the type of antithrombotic prophylaxis performed (class of drug and dose intensity) will be assessed in a large cohort of patients hospitalized in the various participating hospitals in the veneto region and observed with follow-up. in the short term, gathering information on: clinical outcomes, survival, concomitant pathologies, adverse events of anticoagulant drugs, interactions with other concomitant drugs, and risk factors. the collected data, suitably anonymized, will be used to produce scientific works, the standardization of care paths, and the planning of targeted training events.

Eligibility criteria:
inclusion criteria: * proved sars-covid-2 infection exclusion criteria: * none

Keywords: covid-19 pandemic hypercoagulability state thromboprophylaxis heparin
clinical outcomes, viscoelastic properties and central pain mechanisms after eccentric training in neck/shoulder pain

Conditions: Neck Pain; Work-related Injury; Shoulder Pain

Summary: objectives: the aims are to 1) evaluate the clinical impact of eccentric training in female computer users with chronic nsp, 2) compare pressure hyperalgesia, temporal summation of pain (tsp), and conditioned pain modulation (cpm) in female office workers with and without nsp, and 3) assess changes in central pain responses after training. methods: in part a, twenty office workers with nsp will be compared with 20 healthy controls. in part b, the nsp group will undergo a 5-week eccentric training program. participants will report their pain intensity, and complete the neck disability index, and the disabilities of the arm, shoulder and hand questionnaire. pressure pain thresholds (ppts) will be assessed over the neck and forearm. cuff algometry will identify pain detection (pdt) and tolerance thresholds (ptt). tsp will be evaluated by visual analogue scale pain scores during 10 repetitive cuff stimulations. cpm will be calculated as the difference in pdt with and without a conditioning painful stimulus. outcomes will be measured at baseline and post-intervention.


Eligibility criteria:
inclusion criteria: * neck / shoulder pain has to last more than 12 weeks', with an average score higher than 2 on a 11-point numeric pain rating scale within the last 24 hours and during the week before data collection. * all subjects will have to work for a minimum of four hours per day using a computer, should speak and understand english, and could not be involved in regular strength training of the neck/upper extremities exclusion criteria: * previous whiplash; a history of neurological or mental illnesses; consumption of pain killers within the last 24 hours; drug addiction, defined as the use of cannabis, opioids or other drugs; fibromyalgia; previous cervical spine or upper limb surgery; carpal tunnel syndrome; concomitant injury or pain from the lumbar spine; and heart diseases or hypertension.

Keywords: clinical pain hyperalgesia intervention musculoskeletal disorders computer work strength training
pain, reward, attention and neurocircuitry: biomarkers of suicidality

Conditions: Major Depressive Disorder; Suicide; Suicidal Ideation

Summary: the ultimate aim of this study is to identify a biomarker of suicide risk in mdd by measuring the "hedonic spectrum" (pain and reward responsivity), attention and its associated brain structures using brain scans (fmri and dti), as well as the stability of markers over time.

the issue of suicide has continued to puzzle researchers in the field of psychiatry. edwin shneidman, a prominent researcher on suicide emphasized "the most evident fact about suicidology and suicidal events is that they are multidimensional...containing concomitant biological, sociological, and psychological (interpersonal and intrapsychic)...elements". yet, no study to date has attempted to integrate these dimensions when evaluating suicide risk. considering the presence of a psychiatric illness is a primary predictor of suicide, it is important to develop a unified understanding of risk factors that integrate current clinical and neurobiological findings in this population. our aim is to: (1) identify an integrated biomarker model to predict risk of suicide attempt in patients with major depressive disorder (mdd) with and without a history of suicide attempt, using neuroimaging, neurocognitive testing and behavioural tasks, and (2) test the stability of this model using a prospective 1 year design.

Eligibility criteria:
inclusion criteria: 1. dsm-5 criteria for major depressive episode within a mdd, confirmed through mini diagnosis104 2. ages between 18 and 70 years 3. hamilton depression rating scale - 17 item (hamd-17) \>= 14 4. capable of giving informed consent 5. groups 1 and 2 participants only: hamd-17 item 3 (suicide) \>= 2 6. group 2 participants only: positive history of a suicide attempt within the last six months 7. group 3 participants only: positive history of a lifetime suicide attempt exclusion criteria: 1. pregnancy/lactation 2. medical condition requiring immediate investigation or treatment 3. recent (\< 6 months)/current history of drug abuse/dependence (other than caffeine, or nicotine) 4. lifetime history of psychosis, bipolar i or bipolar ii; other axis i comorbidities are allowable 5. individuals who are taking a daily sedative hypnotic, atypical antipsychotic or stimulant must be on a stable dose for at least 4 weeks prior to the neuroimaging scan. the dose must not be taken after 10:00pm the evening prior to the scan. those receiving a benzodiazepine or an atypical antipsychotic on an "as needed" basis (taken, but not every day) will be washed out of their benzodiazepine/atypical antipsychotic for two weeks prior to neuroimaging. those receive stimulants on an "as needed" basis will be washed out for 1-3 days prior to neuroimaging, depending on the stimulant half-life. 6. participation in experimental treatment trials for the study duration.
transcatheter mitral valve replacement in patients with severe symptomatic mitral regurgitation - apollo-eu trial

Conditions: Mitral Regurgitation

Summary: evaluate the safety and efficacy of medtronic intrepid™ tmvr tf system in patients with moderate-to-severe or severe symptomatic mitral regurgitation, or moderate symptomatic mitral regurgitation combined with mitral stenosis in the presence of mac who, by agreement of the local site multidisciplinary heart team experienced in mitral valve therapies, are unsuitable for treatment with approved transcatheter repair or surgical mitral valve intervention.

prospective, single-arm, multi-center, interventional, pre-market trial

Eligibility criteria:
inclusion criteria: * subject has moderate-to-severe or severe symptomatic mitral regurgitation as defined by the american society of echocardiography 2017 guidelines and standards - recommendations for non-invasive evaluation of native valvular regurgitation, or subject has moderate symptomatic mitral regurgitation combined with mitral stenosis with the presence of mac * local site multidisciplinary heart team experienced in mitral valve therapies agrees that patient is unsuitable for treatment with approved transcatheter repair or conventional mitral valve surgery * subject and the treating physician agree that the subject will return for all required post-procedure follow-up visits * subject meets the legal minimum age to provide informed consent based on local regulatory requirements * subjects anatomically suitable for the medtronic intrepid™ tmvr tf system exclusion criteria: * estimated life expectancy of less than 24 months * currently surgically implanted mitral valve * prior transcatheter mitral valve procedure with device currently implanted * anatomic contraindications * anatomically prohibitive mitral annular calcification (mac) * aortic valve disease requiring intervention or previous intervention within 90 days of enrollment * lvef \< 25% (measured by resting transthoracic echocardiogram), patients with lvef 25 - \<30% will be further evaluated by the screening committee for approval (right ventricular dysfunction, pulmonary hypertension, and left ventricular function) * left ventricular end diastolic diameter (lvedd) \> 75mm * need for emergent or urgent surgery * hemodynamic instability * history of bleeding diathesis or coagulopathy * end stage renal disease * liver failure * frailty

Keywords: mitral valve regurgitation tmvr intrepid™ symptomatic severe
molecular and clinical response to a single bout of aerobic exercise in a multimorbid population: a study from the consortium on precision exercise in aging

Conditions: Multimorbidity - End-stage Kidney Disease

Summary: the combination of data from different origins (biological, health, patient-related) has the potential to improve care for the elderly. precision approaches that are emerging in health are based on the premise that a better understanding of the biological responses to interventions will make it possible to optimize the treatments. in the field of exercise, this type of approach is emerging. this pilot study aims to collect preliminary data to demonstrate that a patient-centric vision with data from multiple sources is mandatory to personalize exercise intervention and improve health care. older adults with end-stage chronic disease treated by hemodialysis represent a population of choice that requires personalized care since they are multimorbid and exhibit a complex health profile. on the other hand, the beneficial effects of exercise are still little understood and the avoidance of adverse effects in response to exercise such as hypotension during dialysis remains uninvestigated.objective: demonstrate the feasibility of an integrative approach by combining "omics", clinical data, patient-related outcomes (pro) as well as exercise variables (e.g., intensity, duration) methods: a total of 10 people aged 60 and over will be recruited to randomly perform 2 experimental conditions: hemodialysis alone (cont) or hemodialysis + aerobic exercise (ex), which will be carried out over 2 visits one week apart. these visits will take place at the scheduled time of the hemodialysis treatment. the variables of interest are: blood pressure response to a single bout of exercise exercise (during and post-exercise), symptoms (with visual analogue scales within 36 hours of the visit + dialysis symptom index for the 7 days after the experimental visit), dialysis efficiency (kt/v) and biological response (proteomics and metabolomics). health-related quality of life (kdqol questionnaire), medical data (electronic medical record), and level of physical activity (pase questionnaire and smart watch; apple watch) will be evaluated.


Eligibility criteria:
inclusion criteria: * being treated by hemodialysis for end-stage kidney disease for at least 3 months * medically eligible exclusion criteria: * diagnosed neurocognitive decline * hip fracture with recent hemiarthroplasty preventing hip flexion while pedalling, * covid-19 positive, * already included in another study.
evaluation of 4 mri methods (pdff 3, 6 and 11 gradient echoes and spectroscopy) compared to the reference method (liver biopsy) in quantification of hepatic steatosis

Conditions: Hepatic Steatosis; MRI; Liver Biopsy; Quantification

Summary: evaluation of 4 mri methods (pdff 3, 6 and 11 gradient echoes and spectroscopy) compared to the reference method (liver biopsy) in quantification of hepatic steatosis

hepatic steatosis is an increasingly frequent pathology, which can lead to severe complications (cirrhosis, hepatocellular carcinoma). the poor quantification of steatosis by ultrasound or scanning and the invasiveness of the reference method (liver biopsy) make mri a measurement tool of choice. recent techniques such as proton density measurement with several echoes or spectroscopy are increasingly used for the measurement of steatosis. at the time of the development of therapeutics to reduce fatty liver disease, the use of mri seems an interesting alternative for longitudinal follow-up in these patients. our study aims to ensure the reliability of these different mri techniques for accurate quantification of liver steatosis and to compare them. * measurement and influence of hepatic fibrosis * measurement and influence of intrahepatic iron * influence of intercurrent liver disease * comparison of the fat measurement of the different hepatic segments * reproducibility by measurement of inter-observer concordance

Eligibility criteria:
inclusion criteria: * patients undergoing hepatic biopsy (trans-parietal or trans-jugular) in the context of liver disease * signature of written consent exclusion criteria: * contra-indications to mri * refusal of protocol * underage patients and protected adults

Keywords: hepatic steatosis mrimaging
safety and efficacy of the sterile single-use circular stapling device circcurer ii (jiangxi langhe medical instrument co., ltd., guangzhou, china)

Conditions: Phimosis; Foreskin; Tightness; Redundant Prepuce

Summary: evaluation of the safety and efficacy of the sterile single-use circular stapling device circcurer ii (jiangxi langhe medical instrument co., ltd., guangzhou, china) in comparison with circumcision in adults patients with pathological foreskin (phimosis, stenosis, redundant prepuce)


Eligibility criteria:
inclusion criteria :phimosis, stenosis of foreskin, redundant prepuce exclusion criteria : active inflammation of foreskin