Kornimate/medical-research-clean huggingface dataset:
effects of smoked marijuana on neuropathic pain

Conditions: Neuropathic Pain

Summary: to determine if smoking marijuana will reduce neuropathic pain without causing too much drowsiness or feeling "too dopey".

the case for marijuana's medical use for pain is primarily from experimental studies with normal subjects, which have yielded conflicting results. experimental subjects have been shown to have significant dose-dependant antinociception effect that is not reversed by opioid antagonism. in contrast to this positive antinociceptive effect, other experiments demonstrated hyperalgesic activity and probably enhancement of the perception of pain upon acute exposure in chronic users of marijuana. in addition to studying spontaneous pain antinociception, it would be useful to evaluate the response to marijuana following evoked pain. such evoked pain is produced by stimulation of the skin that is normally not noxious. because of the potential side effects of marijuana administration, one of the aims of the present study is to analyze inter-individual variability and the occurrence of dose-dependant analgesia of marijuana with an eye on defining tolerable dosing in clinical neuropathic pain syndromes. comparisons: neuropathic and experimentally induced pain scores will be compared after the administration of escalating doses of low, high, and placebo marijuana cigarettes as provided by the national institutes on drug abuse (nida).

Eligibility criteria:
inclusion criteria: * able to understand english * age greater than 18 and less than 70 * vas greater than 3/10 * history of previous marijuana use (i.e., avoidance of marijuana naive subjects) * negative urine drug screening test * nerve injury a.k.a. complex regional pain syndrome type ii or * complex regional pain syndrome type i or * neuropathic pain due to confirmed bilateral distal peripheral neuropathy associated with diabetes i or ii, focal nerve injury, postherpetic neuralgia, spinal cord injury with incomplete myelopathy, central pain following a stroke or focal brain lesion, or clinical definite multiple sclerosis of at least 3 months duration. exclusion criteria: * presence of another painful condition of greater severity than the neuropathic pain condition which is being studied * unstable type 1 or 2 diabetes defined as blood glucose more than 156 mg/dl * for diabetic subjects maintained on insulin with a stable blood glucose more than 156 mg/dl, a hemoglobin a1c level of more than 0.11 (normal range, 0.048-0.067) * history of traumatic brain injury * history of schizophrenia or a past or current history of a serious psychiatric disorder that is currently not well controlled with medications * uncontrolled medical condition - coronary artery disease, hypertension, cerebrovascular disease, asthma, tb, copd, opportunistic infection, malignancy requiring active treatment * active substance abuse (alcohol or injection drugs) * current use of marijuana (within 30 days of randomization) as determined by urine screening

Keywords: cannabis marijuana neuropathy antinociception mood cognition
bergonie institute breast cancer database

Conditions: Breast Cancer

Summary: a database of breast cancer patients was established at institute bergonié since the 90s , to assess patients' survival, assess practice, search for prognostic factors.


Eligibility criteria:
inclusion criteria: * breast cancer * aged 18 years and over * first treatment at bergonie institute exclusion criteria: -

Keywords: breast cancer survival prognosis factors
comparison of detection of sars-cov2 (covid-19) between nasopharyngeal swab specimens and those obtained by salivary sputum

Conditions: Covid19

Summary: multicenter observational study of diagnostic test validation (research involving the human person, type 3) in addition to the diagnosis by the reference method (nasopharyngeal swab), the patient will be asked to provide a saliva sample via a salivary spit. the clinical circumstances of the diagnosis, the age of the patient, the associated terrain (diabetes, immunodepression, pregnancy) will be noted. the nasopharyngeal and saliva samples will be analyzed in cayenne and the remaining samples will be frozen and stored at the crb before being sent to the university hospital of caen for analysis and concordance verification. the expected benefits are: possibility of repeating tests in the same person more easily due to the absence of pain and thus reduce the barriers to diagnosis and screening. possibility of self-sampling, which could simply be sent to the laboratory, which would relieve the diagnostic sites that mobilize staff and require a fairly heavy organization. avoid long waiting lines that can be an obstacle and lead to a renunciation of the diagnosis.


Eligibility criteria:
inclusion criteria: * patient with an indication to perform a covid diagnostic test (symptomatology, contact case, systematic screening etc...) * men and women at least 3 years old exclusion criteria: * refusal of the patient or his legal representative, * taking treatments that reduce salivary volume (anticholinergic activity) * impossibility to perform the nasopharyngeal test * patient under guardianship or curatorship, persons placed under protective measures
improving safety and accuracy of stereotactic brain biopsies in primary central nervous system lymphoma.

Conditions: Cerebral Lymphoma

Summary: primary central nervous system lymphoma (pcnsl) is an aggressive extranodal non- hodgkin lymphoma exclusively localized into the nervous system. the aim of this study is to evaluate the mri imaging characteristics of the peritumoral area (pta) and to correlate this information to pathological findings.

primary central nervous system lymphoma (pcnsl) is an aggressive extranodal non- hodgkin lymphoma exclusively localized into the nervous system. it is a relatively rare disorder, accounting for only 3% of all primary brain tumors but due to its anatomical localization represents an important clinical and diagnostic challenge in onco-hematology. different mri patterns of the peritumoral area (pta) might correlate with different histopathological sensitivity regarding diagnostic potential out of contrast-enhanced region (cer). improvements in the understanding of pta diagnostic potentials is of great help in diagnosing patients with deep-seated lesions, who would otherwise be not eligible for stereotactic biopsy and therefore for a consequent adequate treatment.

Eligibility criteria:
inclusion criteria: * adult patients, undergoing stereotactic biopsy for newly diagnosed psncls exclusion criteria: * severe hepatic dysfunction * severe renal dysfunction * severe heart failure * myocardial infarction and stroke within 90 days * hyperreactivity against contrast agents * pregnancy
bi-level positive airway pressure for respiratory distress syndrome in twins infants

Conditions: nCPAP; BiPAP; Respiratory Distress Syndrome

Summary: the investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -bi-level positive airway pressure(bipap) or nasal continuous positive airway pressure (ncpap) -as a primary mode of ventilation in preterm twins infants with respiratory distress syndrome

invasive ventilation is related to development of adverse pulmonary and nonpulmonary outcomes in ventilated infants. various modes of noninvasive respiratory support are being increasingly used to minimize the incidence of bronchopulmonary dysplasia (bpd). the aim of this trial to compare the effects of bi-level positive airway pressure(bipap) and nasal continuous positive airway pressure (ncpap) in preterm twins infants as the primary mode.

Eligibility criteria:
inclusion criteria: * 1. gestational age (ga) is from 26 to 37 weeks; * 2. diagnosis of respiratory distress syndrome. the diagnosis of respiratory distress syndrome will be based on clinical manifestations (tachypnea, nasal flaring and or grunting) and chest x-ray findings; * 3. respiratory distress syndrome silverman score \>5; * 4. informed parental consent has been obtained. exclusion criteria: * 1. severe respiratory distress syndrome requiring early intubation according to the american academy of pediatrics guidelines for neonatal resuscitation; * 2. major congenital malformations or complex congenital heart disease; * 3. group b hemolytic streptococcus pneumonia, septicemia, pneumothorax, pulmonary hemorrhage; * 4. cardiopulmonary arrest needing prolonged resuscitation; * 5. transferred out of the neonatal intensive care unit without treatment.
washed microbiota transplantation improves nutritional status of patients with crohn's disease

Conditions: Crohn's Diseases

Summary: patients with crohns' disease (cd) are always complicated with malnutrition. exclusive enteral nutrition (een) is an effective treatment to improve nutritional status and induce remission in patients with cd however a reduction in microbiota diversity was the most frequently reported effect of een. there was a raised critical question that whether een combining microbiota transplantation can bring much more benefits to those cd patients with malnutrition. fecal microbiota transplantation (fmt) is an effective way of remodeling microbiota. the improved methodology of fmt in our group since 2014 was different from the traditional manual fmt and was recently coined as washed microbiota transplantation (wmt), which is dependent on the automatic facilities and washing process in a laboratory room with biosafety level 3. importantly, the worse nutritional status might decrease the efficacy of fmt. therefore, there was a raised critical question that when is the proper time to combine wmt for those cd patients requiring een. this trial aimed to explore the timing of wmt in cd patients with malnutrition and assess the efficacy and safety of the strategy using wmt combined with een in cd patients.


Eligibility criteria:
inclusion criteria: 1. patients aged 18 to 65 years with active cd, as defined by harvey-bradshaw index (hbi) score \>4; 2. patients accompanied with malnutrition as assessed by nutritional risk screening 2002 (nrs2002) score ≥ 3 or patient-generated subjective global assessment (pg-sga) score ≥ 4; 3. patients with high compliance. exclusion criteria: 1. accompanying with contraindications of enteral nutrition (en) such as ileus, active gastrointestinal bleeding and shock; 2. severe comorbidities (e.g., clostridium difficile infection, diabetes, cancer, cardiopulmonary failure and severe liver and kidney diseases; 3. parenteral infection such as urinary infection, pneumonia, etc; 4. steroids or biologicals use within 6 week; 5. intestinal fibrotic stenosis; 6. patients who are pregnant or going to be pregnant; 7. patients with mental disorders.

Keywords: fecal microbiota transplantation exclusive enteral nutrition washed microbiota transplantation malnutrition
a wearable and a self-management application for chronic obstructive pulmonary disease (copd) patients at home

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: our overall research goal for this project is to create a wearable device and mobile application, appealing to patients with chronic obstructive pulmonary disease (copd), which provides them with appropriate self-management tools and detects aecopds early to permit prompt treatment and prevent severe exacerbations requiring hospitalization.

our overall research goal for this project is to create a wearable device and mobile application, appealing to patients with copd, which provides them with appropriate self-management tools and detects acute exacerbations of copd (aecopds) early to permit prompt treatment and prevent severe exacerbations requiring hospitalization. currently, the investigators are developing a second version of this app, wearcopdv2. this app will incorporate features identified as being desirable from our patient interviews: 1) new sensor that was requested by patients - oxygen saturation, and 2) the app will incorporate a patient-facing interface as patients requested a method to view their data as well as access to information to learn how to manage their condition better. research questions: can an app designed for patients with copd that includes biosensor feedback improve self-management of copd? what is the accuracy of our sensor data (heart rate, activity, respiratory rate, oxygen saturation, coughing, and other sounds of interest) in detecting early aecopds?

Eligibility criteria:
inclusion criteria: * able to speak english * moderate to very severe copd (gold c and d) as defined by the gold guidelines * clinically relevant disease, as defined by a history of exacerbation in the previous 12 months * previous spirometry or pulmonary function test results of forced expiration volume/forced vital capacity (fev1/fvc) \<0.70 with an fev1 below 80% predicted * patient resides at home (not long term care residence or another hospital) exclusion criteria: * pulmonary condition other than copd as the main respiratory disease such as bronchiectasis or asthma * rapid lethal disease, e.g. lung cancer, advance heart failure, end-stage renal disease * any medical conditions that would impair their ability to participate in the study

Keywords: wearables self-monitoring
effect of oral combination therapy in a single dosage form in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: the aim of the study is to determinate the effect of combined oral therapy of long acting metformin/glimepiride in a single dose in patients with type 2 diabetes mellitus and monotherapy failure.

a randomized double-blind clinical trial, to determine the effect of combined therapy of oral prolonged-release metformin/glimepiride in a single dosage form on fasting glucose and hba1c. patients will be included in this study are patients with diabetes mellitus and secondary failure to monotherapy. will also assess the effect of combined therapy on the oral lipid profile (total cholesterol, ldl, hdl, vldl, triglycerides) and on the sensitivity and insulin secretion. we evaluate the clinical measurements, laboratory and safety during 3 months, through the allocation of subjects to three study groups (metformin, glimepiride and metformin extended release / glimepiride)

Eligibility criteria:
inclusion criteria: * 40 to 65 years old * ability to communicate and to meet the requirements of the study * signed written informed consent before to conducting any study * body mass index (bmi) = 25-40kg/m2 * stable weight in the past three months (variability \<5%) * meal plan and monotherapy with oral hypoglycaemic fails * fasting glucose = 130-270 mg/dl * hba1c \> 7% * isocaloric diet with a minimum of 250 grams of carbohydrates per day in the three days prior to making the laboratory tests exclusion criteria: * suspected or confirmed pregnancy * nursing * inability to secure the non-pregnant during the study duration * hypersensitivity to any of the drugs under study * treatment with oral hypoglycemic or insulin * consumption of substance with toxic effects on any organ system * liver failure, heart failure, kidney failure or thyroid disease * chronic intake of alcohol * periods of acute or chronic diarrhea or vomiting * consumption of antifungal azoles, mao inhibitors, nifedipine,furosemide, amiloride, digoxin, procainamide, quinidine, quinine, triamterene and vancomycin
prosocial behavior and volunteerism to promote physical activity in older adults

Conditions: Physical Activity

Summary: the purpose of this 12-month study is to compare how well two programs help older adults make physical activity a regular habit.

although only a small percentage of older adults engage in habitual physical activity, previous studies have demonstrated interventions that include cognitive-behavioral strategies can enhance long-term, independent physical activity. in addition, there are episodic charity events, such as charity walks, that attract large numbers of participants of all age ranges to engage in moderate-intensity physical activity. these actions are a form of prosocial behavior, defined as voluntary, intentional behavior that results in benefits for another. the opportunity to help others seems to be a motive in inspiring these individuals to at least engage in one session of moderate physical activity. thus, the current research project contemplates whether prosocial behavior may be implemented as a viable behavioral incentive for long-term physical activity. participants in the prosocial behavior physical activity (pbpa) intervention will receive a cognitive-behavioral intervention to teach participants the behavioral skills necessary to engage in long-term (12-month) independent physical activity. participants in the healthy aging (ha) intervention will receive excellent educational sessions based on a number of topics of relevance to older adults. both programs will provide supervised stretching sessions so that participants learn how to safely and effectively improve flexibility, which helps reduce the likelihood of falls and disability. however, the pbpa intervention will also allow participants to earn food for donation to second harvest food bank based on their regular physical activity and volunteer time.

Eligibility criteria:
inclusion criteria: * age 55 years or older * physically underactive * no evidence of any major psychological illness * residence within 20 miles of study site * plans to remain in area for duration of study exclusion criteria: * currently engaging in regular physical activity * self-reported evidence of cardiovascular disease * self-reported evidence of diabetes * self-reported falling within the past year * alcohol consumption greater than 14 drinks per week * inability to understand english * plans to move from area * participation in another medical intervention study * severe hearing or sight impairments

Keywords: physical activity older adults physical function health-related quality of life prosocial behavior social cognitive theory
decreasing postoperative blood loss by topical vs. intravenous tranexamic acid in open cardiac surgery

Conditions: Bleeding; Surgical Blood Loss

Summary: the aim is to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (ta) versus the usual intravenous ta in patients undergoing cardiac surgery at the hamilton general hospital. this pilot study will assess the feasibility to perform a large randomized international trial exploring this objective.

postoperative bleeding related to open cardiac surgery increases the rates of complications and mortality. it results from the blood thinners that are needed for use. intravenous tranexamic acid (ta) has become a mainstay in cardiac surgical procedures for decreasing bleeding and minimizing transfusion requirements. although intravenous ta is usually well tolerated, there is a well-known risk (1 to 4%) of postoperative seizures. this is due to the similarity between ta and the brain tissues. the aim is to eliminate the risk of seizures but to maintain the protection against bleeding. when ta is used directly on the tissues (topically) for other type of surgeries (joints), ta is effective to reduce blood loss and transfusions. the aim is to prove that direct application of ta on the heart can eliminate postoperative seizures and reduce the amount of blood transfusions in patients who have cardiac surgery.

Eligibility criteria:
inclusion criteria: * male or female \>= 18 years old * undergoing cardiac surgical procedure with the use of cardiopulmonary bypass and median sternotomy * provide written informed consent exclusion criteria: * poor (english) language comprehension * minimally invasive valve surgery * off-pump procedures * emergency operations * known history of increased bleeding disorder * thromboembolic disease * allergy to tranexamic acid * severe renal impairment (egfr \<30 ml/min/1.73m2 )

Keywords: tranexamic acid cardiac surgery
feasibility study of incorporating 18f-fdg-pet imaging in radiotherapy for head and neck cancer

Conditions: Head and Neck Neoplasms

Summary: the purpose of this trial is to study fluorodeoxyglucose-positron emission tomography (fdg-pet)-based dose escalation using intensity modulated radiation therapy (imrt).

the dose escalation, based on the fdg-pet signal, is incorporated in the first ten fractions of the radiotherapeutic treatment. the total amount of fractions is 32, equal to a standard radiotherapeutic treatment for these types of cancers.

Eligibility criteria:
inclusion criteria: * patients with a proven histological squamous cell carcinoma of the larynx (only t3-4 no or tany n+), hypopharynx, oropharynx * patients who did not undergo surgery for the primary tumor location * patients with a karnofsky performance score of 70% or more * written informed consent for participation in this trial exclusion criteria: * other malignancy except for non-melanoma skin cancer * prior irradiation to the head and neck region

Keywords: neoplasms (squamous cell carcinoma of the head and neck region)
impact of kolcaba comfort theory training on dyspnea, function, and comfort in copd patients

Conditions: Main Heading (Descriptor) Terms

Summary: chronic obstructive pulmonary disease (copd) is the third most fatal chronic disease worldwide, following cardiovascular diseases and cancer. copd is characterized by chronic respiratory symptoms due to abnormalities in the airways (bronchitis/bronchiolitis) or alveoli (emphysema), leading to persistent and often progressive airway obstruction. patients frequently experience a range of physical and psychosocial symptoms, including dyspnea, cough, sputum production, fatigue, anxiety, and depression. dyspnea, in particular, can significantly reduce quality of life, impair daily activities, and affect patient comfort. functional status is a crucial metric for assessing disease progression and symptom severity in copd and is directly related to the intensity of symptoms such as dyspnea. effective management of symptoms and enhancement of comfort levels are critical in copd treatment. kolcaba's comfort theory provides a comprehensive approach to nursing care by addressing physical, psychospiritual, social, and environmental dimensions of patient needs. this theory can be an effective guide for improving comfort in copd patients. the objective of this study is to evaluate the effects of using kolcaba's comfort theory as a guide in managing symptoms and enhancing the quality of care for copd patients, focusing on dyspnea, functional status, and comfort. the research aims to provide innovative insights into the impact of comfort theory-based nursing care in sensitive patient populations like those with copd and to contribute valuable information for developing effective treatment and management strategies for symptom control.


Eligibility criteria:
inclusion criteria: * be 18 years of age or older. * have been diagnosed with copd for at least 6 months. * be in gold stages 1, 2, or 3 of copd. * be able to read and write in turkish. * have access to a phone for communication. exclusion criteria: * patients experiencing an acute exacerbation. * presence of non-copd pulmonary problems or diagnosed cardiovascular diseases. * psychiatric disorders that disrupt thought processes, such as dementia or schizophrenia. * respiratory issues caused by diseases other than copd. * problems with communication or speech. * use of a respiratory exercise device (pep). * inability to tolerate pep use. * desire to withdraw from the study at any point.

Keywords: copd dyspnea functional status comfort states kolcaba's comfort theory education