Kornimate/medical-research-clean huggingface dataset:
dose reduction of postoperative radiation for soft tissue sarcoma of the arms and legs

Conditions: Soft Tissue Sarcoma

Summary: the investigators are doing this study to find out whether lowering the dose of postoperative radiation therapy and targeting a smaller area of tissue for treatment is as effective as the standard dose and volume of radiation therapy to control soft tissue sarcoma after surgery. they also want to find out whether the study approach causes fewer and less severe long-term side effects than the standard approach.


Eligibility criteria:
inclusion criteria: * patients must be diagnosed with a primary soft tissue sarcoma of the extremity, confirmed by mskcc pathologic review * age at the time of enrollment of ≥18 years * patients must have undergone margin-negative oncologic resection of their primary tumor, as confirmed by mskcc pathologic review * patients must be able to start radiation within 3 months from time of surgery °if patient is receiving adjuvant chemotherapy, patient must start rt no longer than 3 months past their chemo treatment. * female patients of childbearing potential must have a negative serum pregnancy test within 14 days of radiation start (or if urine test, within 24 hours of radiation start) * sexually active patients of childbearing potential must agree to use effective contraception. * the use of chemotherapy will not be dictated by this trial. patients are allowed to receive chemotherapy at the discretion of the disease management team (as is standard practice to make individualized decisions for each patient regarding the use of chemotherapy). exclusion criteria: * patients with positive margins after surgical resection as indicated by mskcc pathologic review * patients with diagnosis of superficial myxofibrosarcoma with indistinct/infiltrative borders on preoperative mri16 (see appendix figure 1 for reference figure) * patients with multifocal disease in the extremity * patients who have received prior radiotherapy at or adjacent to the primary tumor bed * patients with a differentinvasive cancer requiring active treatment at the time of enrollment. * patients with any concurrent medical or psychiatric condition or disease which, in the investigator's judgment, would make them inappropriate candidates for entry into this study

Keywords: postoperative radiation soft tissue sarcoma of extremity 20-064
remote cognitive assessment for surgical patients

Conditions: Mild Cognitive Impairment; Delirium

Summary: this is a pilot study to evaluate the use of remote cognitive testing to identify patients who may have cognitive vulnerability and may benefit from cognitive care pathways. participants in this study are asked to complete a smartphone battery of thinking, memory, speech, and motor function tests on their smartphone.

this study is evaluating cognitive function in older adults that are undergoing surgery using remote assessments. participants complete a battery of neuropsychological assessments prior to their surgery date. the battery includes smartphone adaptions of tests of thinking, memory, speech, and movement. the participant has a one-hour remote visit, where the investigators will conduct a montreal cognitive assessment (moca) and have the participant complete the smartphone assessments. after their surgery, participants are evaluated on the delirium rating scale.

Eligibility criteria:
inclusion criteria: * spine surgery with a duration greater than or equal to three hours * can speak, write, and understand english * ability to participate in remote visit exclusion criteria: * participating in other cognitive studies * having more than one surgery (planned multiday surgery) * emergency surgery

Keywords: remote cognitive assessment
low-level laser therapy for genitourinary syndromes and stress urinary incontinence

Conditions: Vaginal Atrophy; Urinary Incontinence,Stress

Summary: genitourinary syndrome of menopause (gsm) and stress urinary incontinence (sui) are common for women. low-level laser therapy (lllt) was applied for wound healing, but there was no study regarding treatment effect of gsm and sui. this retrospective study aims to assess the efficacy of lllt in alleviating gsm and sui.

between september 2022 and august 2023, all women who received lllt for gsm and sui at the gynecologic outpatient clinic of a hospital were retrospectively reviewed. the treatment was once a week for eight weeks. vaginal health index (vhi) and questionnaires before and after treatment for evaluation of lower urinary tract symptoms (luts) and quality of life are the outcome assessment.

Eligibility criteria:
inclusion criteria: * women with gsm and sui * received lllt at the gynecologic outpatient clinic exclusion criteria: * more or equal to stage 2 pelvic organ prolapse defined by pelvic organ prolapse-quantification system * ongoing urinary tract infection or vaginitis with the pathogen in the previous 2 weeks * bladder calculus * neurogenic bladder due to radical hysterectomy or injury of the central nervous system * a preexisting malignant pelvic tumor.

Keywords: menopause stress urinary incontinence vaginal atrophy low-level laser therapy
measurement of tricuspid regurgitation volume for assessment of tricuspid regurgitation using 3d transesophageal echocardiography

Conditions: Tricuspid Regurgitation

Summary: this study is a prospective observational chart review. the aim of the study is to evaluate tricuspid regurgitation volume using 3d volumetric assessment as an accurate method for tricuspid regurgitation severity in comparison to vca.


Eligibility criteria:
inclusion criteria: -all degrees of tricuspid regurgitation minimal, mild, moderate and severe will be included exclusion criteria: * exclusion criteria will be non-sinus rhythm, more than mild pulmonary regurgitation, more than trace aortic regurgitation.
study to assess the efficacy and safety of ski3246 in subjects with non-constipation irritable bowel syndrome

Conditions: Non-constipation Irritable Bowel Syndrome

Summary: the purpose of this study is to determine the efficacy and safety of different doses of ski3246 compared with placebo in the treatment of patients with irritable bowel syndrome with non-constipation.


Eligibility criteria:
inclusion criteria: * have been diagnosed as non-constipation by rome iii. * patients who voluntarily signed written informed consent may participate in the study. exclusion criteria: * pregnant or lactating female. * patients with a history of inflammatory bowel disease. * severe neurological or psychological disease * history of allergic reaction to the medications used in this study * use of other investigational drugs within 30 days prior to the study. * patients that investigators consider ineligible for this study
trial of transcranial direct current stimulation (tdcs) for depression

Conditions: Major Depression

Summary: among antidepressant treatments, ect stands as the most effective in treating acute depression. however, patient concerns with the cognitive side effects of ect have encouraged the development of new and more focal forms of brain stimulation such as transcranial direct current stimulation (tdcs). however, not all patients may respond to this treatment in the way that it is currently administered and this has raised interest in finding alternative, possibly more optimal ways of administering tdcs. this study will investigate whether tdcs stimulation using an alternative electrode montage has antidepressant effects.


Eligibility criteria:
inclusion criteria: 1. subject meets criteria for a dsm-iv major depressive episode. 2. total madrs score ≥20. 3. subject has not responded to tdcs given with a standard montage or subject is unable to receive tdcs with standard montage - for example, due to skin rash etc at site of electrode placement for standard montage. exclusion criteria: 1. diagnosis (as defined by dsm-iv) of: any psychotic disorder (lifetime); eating disorder (current or within the past year); obsessive compulsive disorder (lifetime); post-traumatic stress disorder (current or within the past year); mental retardation. 2. history of drug or alcohol abuse or dependence (as per dsm-iv criteria) within the last 3 months (except nicotine and caffeine). 3. inadequate response to ect in the current episode of depression. 4. subject is on regular benzodiazepine medication which it is not clinically appropriate to discontinue. 5. subject requires a rapid clinical response due to inanition, psychosis or high suicide risk. 6. neurological disorder or insult, e.g., recent stroke (cva), which places subject at risk of seizure or neuronal damage with tdcs. 7. subject has metal in the cranium, skull defects, or skin lesions on scalp (cuts, abrasions, rash) at proposed electrode sites. 8. female subject who is pregnant. 9. participants who are not fluent in english will not be included in the trial for safety reasons: a) it is usually not possible to have an interpreter reliably available every weekday for up to 4 weeks and it is not safe to give tdcs to a subject who cannot tell us immediately of any side effects; b) as this is a novel treatment, the study involves detailed neuropsychological testing for safety reasons. this testing cannot be effectively or validly completed by someone who is not fluent in english. note that translation of the proposed tests into english has not been validated and that we cannot be confident that neuropsychological impairment would be detected using this method.

Keywords: depression direct current stimulation alternative electrode montage
total-body pet / ct in the evaluation of treatment and prognosis of lymphoma

Conditions: Lymphoma

Summary: the prospective study aims to explore the value of total-body pet/ct dynamic imaging (uexplorer) in assessing the treatments and prognosis in patients affected with lymphoma. total-body 18f-fdg pet/ct scans are being performed before treatment, after three cycles of chemotherapy and six weeks after the end of treatment. the plan of this study involves to evaluate the clinical application of total-body pet / ct in patients histopathologically-diagnosed as lymphoma, and to optimize the dynamic acquisition protocols with total-body 18f-fdg pet/ct.

100 cases of lymphoma patients are enrolled in this study. participation in this study involves three dynamic 18f-fdg pet/ct exams, which occur before the treatments start, two or three days before the fourth cycle of chemotherapy, and then six weeks after the end of last treatments. progress free survival(pfs) and overall survival(os) are used as the end points to study the value of metabolic parameters obtained from the dynamic pet/ct imaging. the differences of dynamic metabolic parameters and static suv value are evaluated in patients with lymphoma from the perspective of diagnosis, staging, treatment and prognosis.

Eligibility criteria:
inclusion criteria: * provision of signed, written and dated informed consent prior to any study specific procedures * had histologically confirmed lymphoma * patients aged 18\~75 years old exclusion criteria: * female patients who are pregnant, breast-feeding * currently active second malignancy other than lymphoma * any situation not suitable for this study judged by researchers

Keywords: lymphoma, total-body pet/ct, prognosis, dynamic imaging
evaluating risk factors of post-lasik ectasia

Conditions: Corneal Ectasia

Summary: ectasia after refractive surgery is a relatively rare complication which can lead to sight-threatening complications if not detected and treated in time. it is important to continue our quest to improve our methods of identifying absolute and relative risk factors of ectasia following various keratorefractive surgical procedures.

surgical correction of refractive errors is becoming increasingly popular. in the 1990s, the excimer laser revolutionized the field of corneal refractive surgery with prk and lasik, refractive lenticule extraction (relex) of intracorneal tissue using only a femtosecond laser, and lately relex smile (smile). the term lasik (laser in situ keratomileusis) was first used in 1990 by pallikaris, in which a microkeratome was used to cut a hinged corneal flap, followed by excimer ablation of the stromal bed and flap repositioning . lasik is known to be a safe refractive surgical procedure, with good refractive efficacy and predictability and is associated with rapid visual recovery with minimal risk of complications. most of complications are flap related and include a free cap, a button hole, an incomplete cut, flap striae, interface debris, diffuse lamellar keratitis (dlk), and epithelial ingrowth. other complications include undercorrection, overcorrection, decentered ablation, irregular ablation, and ectasia. corneal ectasia is a sight-threatening complication of laser refractive surgery characterized by progressive steepening and thinning of the cornea.it is defined as progressive stromal thinning and steepening of the cornea, resulting in refractive aberrations and visual deterioration. the incidence of post- lasik ectasia is estimated to be between 0.04% and 0.6%.corneal ectasia has been observed to occur as early as 1 week and as late as several years after lasik. the main purpose of assessing risk is to determine what group or groups of people present a higher chance to develop post-lasik ectasia. the development of postoperative ectasia varies between lasik centers and depends on the screening tools used to screen candidates, the experience and technical skill of the surgeon, and the tools used during the surgery. risk factors for the development of post-lasik ectasia include young age, a personal or family history of keratoconus, forme fruste keratoconus (ffkc), high myopia, low-residual stromal bed (rsb), and deep primary keratotomy resulting in a thick flap. although several risk factors have been identified for the likelihood of ectasia development after keratorefractive surgeries, some cases have been reported to develop in an enigmatic way, without the prescence of any of these risk factors.

Eligibility criteria:
inclusion criteria: * all subjects presented with ectasia following lasik exclusion criteria: * any associated ocular pathology. * any previous ocular surgeries other than lasik. * corneal opacities. * ocular trauma.
different surgical modalities for thigh lipodystrophy including liposuction,thigh lift and liposuction assisted thigh lift

Conditions: Thigh Lipodystrophy

Summary: the sample will be divided into two groups:- - control group which will include 60 adult individuals between 18 and 35 years old who have bmi between 19 and 25, not complaining of any thigh contour deformities or skin redundancy with no history of body weight fluctuations. this group will be divided into two subgroups, 30 males and 30 females. the following measurements will be recorded :- weight, height, thigh length, hip circumference, maximum buttocks circumference, upper thigh, middle thigh and lower thigh circumferences. - patient group which will include 40 patients suffering from thigh lipodystrophy and contour deformities who will undergo surgical intervention after their assessment. after assessment, one of the following techniques will be selected:- * liposuction only. * thigh lift. * liposuction assisted thigh lift.

preoperative assessment:- patients will be assessed regarding skin redundancy, history of weight loss and site of lipodystrophy whether deformity is proximal, distal or diffuse. the same measurements mentioned above will be recorded for the patient group before surgery. preoperative photographs in anteroposterior, lateral and oblique positions will be taken. informed consent will be signed by the patient before surgery illustrating possible risks and complications of the surgery. postoperative assessment:- the outcomes will be evaluated 3 months after surgery regarding patient satisfaction and achievement of symmetry. early complications will be assessed within one week after surgery including hematoma, seroma, surgical site infection and wound dehiscence. late complications will be assessed at 3 months follow up including asymmetry, conspicuous scar and lymphedema. postoperative measurements and photographs will be recorded and compared with preoperative ones.

Eligibility criteria:
inclusion criteria: 1. individuals between18 and 35 years for control group and more than 18 years for patient group . 2. patients with bmi between 19 and 25 for control group and less than 35 for patient group. exclusion criteria: 1. individuals less than 18 years. 2. patients undergoing bariatric surgery within a period of less than one year. 3. patients with bmi more than 35. 4. patients with systemic illness as cancer or mental disorders \& hepatic patients (generally debilitating diseases) or any contraindication for anesthesia.
transcriptomic study of adult population with marfan syndrome

Conditions: Marfan Syndrome; Marfan's Syndrome With Cardiovascular Manifestations

Summary: this project is designed to discover circulating biomarkers for aortic aneurysms in adults affected by marfan syndrome (mfs). the first aim is to identify circulating transcripts, protein-coding (mrna) and not (ncrnas), which show differential expression between three groups of adult patients affected by mfs, based on: presence or absence of thoracic aortic aneurysms (taa) and indication of taa-surgery. this obtained taa_mfs_signature will then be correlated to fundamental biological parameters, like cytokines and chemokines relevant during inflammation and transcriptomic as well as epigenetics changes in aortic aneurysm tissue. furthermore, the association of taa_mfs_signature to genetic, clinical and instrumental parameters at present used for diagnosis and treatment, will be evaluated.

the investigators will collect peripheral blood and aortic aneurysm tissues specimens from consenting subjects. for all three groups of mfs patients, total rna will be isolated from peripheral whole blood, plasma and peripheral blood mononuclear cell (pbmc) and processed for transcriptomic analyses by rnaseq. plasma will be used to determine cytokine and chemokine levels, using a luminex panel designed for inflammation biomarkers (serum proteomics). for all patients undergoing surgery, tissue specimens will be used for transcriptomic and epigenetic analysis, histological sections and serum proteomics.

Eligibility criteria:
inclusion criteria: general criteria: * clinically and genetically determined marfan syndrome (according to the revised ghent-criteria 2010) * signed informed consent * patient receiving regular pharmacological prophylaxis or newly diagnosed patients population without thoracic aortic aneurysms (taa) patients with clinically and genetically determined marfan syndrome, presenting thoracic aortic diameters within established normal limits (mm and base z-score). population with taa "stable dimensions" patients with clinically and genetically determined marfan syndrome, presenting stable values for dimension / z-score of the aortic root during the 12 months preceding the enrolment. population with taa with surgery indication: * patients with clinically and genetically determined marfan syndrome, presenting indication for surgical correctional according to the relevant international guidelines * trend of uncontrolled increase of aortic diameter compared to previous measurements * aortic ectasia associated to a clinically significant valve dysfunction * evaluation of cut-off for surgical intervention dependant also on familial dissection exclusion criteria: * patients with chronic or acute inflammation states, like: chronic liver disease, chronic renal insufficiency (creatinine \> 1.5 mg/dl) and diseases affecting the thyroid apparatus. * pregnancy

Keywords: thoracic aortic aneurysm
pirfenidone effect on the recovery of renal function in septic acute kidney injury

Conditions: Acute Kidney Injury; Sepsis

Summary: patients with septic aki will be randomized in three arms, group pfd 1,200 will receive pdf 600mg every 12 hrs per mouth, group pdf 600 will receive pfd 600mg in the morning and placebo equivalent at night and group placebo will receive placebo every 12 hrs, all for 7 days, all receive conventional treatment kdigo guides. we analyze the recovery of renal function as a primary objective.

septic acute kidney injury (aki) is the most common cause of aki in the world, there is no specific treatment for this pathology; the pathophysiology is related to inflammatory pathway and strategies that modulate this are potentially useful. the pirfenidone (pdf) is an anti-fibrotic and anti-inflammatory treatment, in animal models has shown a beneficial effect on the recovery of renal function immediately after administrated. the investigators propose a triple blind clinical trial,in which septic aki patients will be randomized in three arms, all receive conventional treatment kdigo guides, grouppdf 1,200 will receive pdf 600mg every 12 hrs per mouth, group pdf 600 will receive 600mg in the morning and placebo equivalent at night and group placebo will receive placebo every 12 hrs, all for 7 days. the investigators analyze the recovery of renal function as a primary objective, as a secondary objectives clinical variables associated with renal recovery, biochemical variables, inflammatory, molecular variables and measurement of pdf in blood will be analyzed. patients will be follow-up for 7 days and 28 days after randomization.

Eligibility criteria:
inclusion criteria: . sepsis * aki by serum creatinine, according to the kdigo guide 2012 acute kidney injury • acute on chronic kidney disease (baseline creatinine \<2 mg / dl) exclusion criteria: * chronic kidney disease stage 3b, 4 or 5 (basal serum creatinine \> 2mg/dl) known and / or sharpened. * chronic dialysis (peritoneal dialysis or hemodialysis) * history of aki and / or rrt in the last three months * pregnancy aki by other causes other than sepsis

Keywords: septic acute kidney injury pirfenidone
analgesic current therapies for chronic neck pain

Conditions: Chronic Neck Pain

Summary: does the use of analgesic current therapies increase the effectiveness of neck stabilization exercises for improving pain, disability, mood, and quality of life in chronic neck pain? a randomized, controlled, single-blind study

analgesic therapies; such as interferential current (ifc) and transcutaneous electrical nerve stimulation (tens) have been applied solo or combined with exercise for management of neck pain (np), however, the efficacy of these combinations are unclear. in this study, our objective were to determine if tens or ifc increase the effectiveness of neck stabilization exercises on pain, disability, mood, and quality of life for chronic np. 81 patients with chronic np were included in the study. patients were randomly assigned into 3 groups; group i: neck stabilization exercise, group ii: tens+ neck stabilization exercise and group iii: ifc+ neck stabilization exercise. patients' pain levels (visual analogue scale (vas)), quality of life (short form- 36), mood (beck depression inventory (bdi)), levels of disability (neck pain and disability index) and the need for analgesics were evaluated prior to treatment, at 6th and 12th week follow-up. all participants had group exercise accompanied by a physiotherapist for 3 weeks and an additional 3 weeks of home exercise program.

Eligibility criteria:
inclusion criteria: * both genders between 20-50 years, had chronic neck pain exclusion criteria: having disc hernia that causes neurological deficit * having malignity, * having neck pain secondary neurological or vascular disease. * pregnancy * having psychiatric disease * having arthritic disease * having any contraindication for electrotherapy

Keywords: tens interferential current therapy chronic neck pain