Kornimate/medical-research-clean huggingface dataset:
teaching math skills to individuals with fragile x syndrome

Conditions: Developmental Disabilities; Fragile X Syndrome

Summary: children with fxs are predisposed to manifesting a particular profile of intellectual strengths and weaknesses, including specific deficits in math, visual-spatial skills, executive functioning, and social skills. until now, intensive behavioral interventions have not been targeted to syndrome-specific weaknesses. in the present study we will develop and evaluate behavioral strategies to aid skill acquisition in children with fxs.

there are no experimental data of skill acquisition using matching-to-sample techniques (or any other specific cognitive intervention) conducted with individuals with fxs. further, no studies have been conducted to examine the possible underlying or mediating brain processes involved during matching-to-sample skill acquisition in children with fxs or any other neurodevelopmental disorder. previous pilot data have indicated that the computerized match-to-sample procedure, even when conducted in time-limited sessions, may significantly help individuals with fxs learn new skills. we plan to utilize brain imaging methodology to compare functional connectivity networks for those who pass and those who fail the equivalence test. 30 subjects with fxs and 30 control subjects with idiopathic developmental disability will be enrolled in the study. all subjects will be enrolled at stanford.

Eligibility criteria:
inclusion criteria: * (a) 10 to 23 years of age (this age range was chosen to maximize the probability that subjects will cooperate with the imaging procedures as well as benefit from the interventions), * (b) in good physical health, * (c) able to participate in the imaging component of the project, * (d) iq between 50 and 80. we have found that individuals with iq's less than 50 points are generally unable to comply with the scanning procedures. * (e) diagnosis of fxs (for fxs group) and non-specific developmental disorder (for control group). exclusion criteria: exclusion criteria include * contraindications for mri (e.g., pacemaker, braces), * the presence of neurological or sensory problems not associated with the conditions of interest (e.g., head trauma, blindness), or inability to discontinue psychotropic medication for 4 weeks prior to the scan. * additional exclusion criteria for the control group include the presence of any known identifiable syndrome (e.g., fragile x syndrome, down syndrome, prader-willi syndrome, turner syndrome, pku, fetal alcohol syndrome, williams syndrome).
equine-assisted therapy for therapy-resistant adolescents with autism spectrum disorders, a replicated ab-design

Conditions: Emotion Regulation; Autism Spectrum Disorder; Adolescent - Emotional Problem

Summary: the purpose of this study is to assess the (cost)effectivity of equine assisted therapy in adolescents with autism spectrum disorders.

the study has a mixed-methods strategy consisting of three elements: a randomized, multiple-baseline single-case design (n=35), a qualitative study (n=8-10) and a cost-effectiveness study (n=6). after obtaining written informed consent, participants will be randomly assigned to one of the five pre-defined baseline lengths (2-6 weeks) to increase the internal validity of the design.

Eligibility criteria:
inclusion criteria: * between 11-18 years old; * a clinical diagnosis of autism spectrum disorders according the diagnostic and statistical manual of mental disorders 5 (dsm 5) as diagnosed by a beroepen in de individuele gezondheidszorg (big) registered healthcare professional; * insufficient emotion regulation after regular therapy for at least 1,5 years as indicated by a score above clinical cut-off (t-score = 65) on the edi; * comorbidities are allowed except for those interfering with safety. exclusion criteria: * unable to respond to questions (parents or adolescents); * no access to an internet connection; * insufficient mastery of dutch language in parents or adolescents; * physically incapable to work with the horses; * unstable medication use; * total intelligence quotient (iq) equal to or below 80 on the wechsler intelligence scale for children (wisc-iii-r or wisc-v); * allergic or phobic to horses; * insufficient regulation to safely handle the horses; * therapy with horses within the last two years.
ability of metoprolol to alter the exercise induced elevation of catecholamines

Conditions: Heart Failure

Summary: heart failure is a frequent disease in denmark, and it is associated with very high mortality. around 60,000 people in denmark have heart failure, and there is about 11,000 hospitalizations every year due to this disease. from the time of diagnosis, patients survive an average of 4-5 years. a critical illness mechanism in heart failure is that these patients have high blood levels of catecholamines; epinephrine and norepinephrine, which is stress hormones from the sympathetic nervous system. standard treatment of heart failure is with the two medical preparations betablockers and ace-inhibitors. it is not known what effect betablocker-treatment have on blood concentration of epinephrine and norepinephrine. it is the purpose of this study, to investigate the effect of selo-zok ® (metoprolol) on the blood concentration of epinephrine and norepinephrine. this is done by creating a stress condition for the body, in this case with the bicycle test, while doing blood samples to determine the concentration of catecholamines. this will be done by 1-week treatment of tablet selo-zok ® followed by 1-week treatment of placebo (a substance with no medical effect). blood samples will be taken to determine small changes in inheritance material (dna) in the form of point mutations also called single nucleotide polymorphisms, since these changes can affect how we respond to metoprolol treatment.


Eligibility criteria:
inclusion criteria: * kaukaser * healthy men * 18 years \< age \< 30 years * non-smoker * 18 \< bmi \< 25 * no chronic diseases * motor-disability that disables completement of cardio-pulmonary exercise-test. exclusion criteria: * alcohol abuse or any other abuse * intake of any narcotic drugs (example: cannabinoids, narcotics, stimulants of central nervous system, hypnotics, hallucinogenes) * any of following medication: * astmamedication * heartmedication * antihistamines * antipsycotics * nsaids * rifampicine * chinidine * glucocorticoids * abnormal ecg, particularly 2. or 3. degree av-block, sinusbradycardia, sick sinusnode-syndrome, sign of heart failure or ischemia. * allergy or intolerance of metoprolole * lactoseallergy * 110 mmhg \< systolic blood pressure \< 140 mmhg * 60 mmhg \< diastolic blood pressure \< 90 mmhg * bloodsucker \> 11,1 mmol/l, or fasting, venous bloodsucker \>= 7,0 (measured if: 7,8 \< bs \< 11,1)

Keywords: snp catecholamines metoprolole healthy subjects physiological stress
autobiographical specificity

Conditions: Memory; Alzheimer Disease; Frontotemporal Dementia

Summary: autobiographical memory is diminished in patients with alzheimer's disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific memories. however, this study proposes a detailed methodology to provide a qualitative analysis of autobiographical specificity.

patients with alzheimer's disease and those with behavioral variant of frontotemporal dementia will be invited to retrieve autobiographical memories. memories will be analyzed and categorized into specific, categoric, extended, or semantic autobiographical retrieval.

Eligibility criteria:
inclusion criteria: * alzheimer' disease or avioral variant of frontotemporal dementia * no opposition from the patient to be included in the study * for alzheimer's patients: a score of more than 24 out of 30 on the mini mental state examination (mckhann et al., 1984) exclusion criteria: * other psychiatric/neurological disorders * minor patients * adults under guardianship or protection.

Keywords: autobiographical memory alzheimer's disease with behavioral variant of frontotemporal dementia
novel biomarkers of preeclampsia, aquaporin, fatty acid, and s110b

Conditions: Preeclampsia

Summary: this is a research study designed to help identify preeclampsia in pregnant women earlier, and possibly lead to better treatment for women preeclampsia.

there is a paucity of biomarkers to predict preeclampsia and for predicting the severity of preeclampsia. this study was designed to identify novel biomarkers for both the prediction of preeclampsia in previously normal pregnancies and for the prediction of the severity of preeclampsia in preeclamptic women. the investigators plan to perform targeted testing for markers that the investigators predict based on their findings or based on available published evidence and the investigators also plan testing for novel markers using various approaches such as proteomics, lipidomics and genomics. the targeted markers will include aquaporin 4 (aqp4), soluble aquaporin fragments, chemokines, and halogenated fatty acids in the plasma and/or spinal fluid. aquaporin fragments and aqp4 have been hypothesized to correlate with severe headaches which are complications of severe preeclampsia. the investigators found in their murine studies that there is a correlation between the presence of halogenated fatty acids in the plasma and elevated blood pressure in a murine model of preeclampsia. the approaches will complement the targeted analyses to identify novel markers that have not been predicted yet.

Eligibility criteria:
inclusion criteria: * greater than or equal to 20 years of age * greater than 24 weeks of gestation * obstetrics/anesthesia team had decided that combined spinal/epidural (cse) or spinal anesthesia will be performed exclusion criteria: * pre-pregnancy comorbidities: * hypertension, diabetes, or pulmonary hypertension * use of steroids, beta blockers, ca channel antagonist, anticoagulants * cardiac or vascular conditions * severe headaches or visual disturbances * inability to receive cse or spinal anesthesia * chorioamnionitis, fever, bronchitis, pneumonia

Keywords: preeclampsia pregnancy complications eclampsia aquaporin aquaporin 4
transcranial doppler during liver transplantation

Conditions: Liver Transplantation; Ultrasonography, Doppler, Transcranial; Complication, Postoperative; Neurologic Deficits

Summary: this is a prospective study that would investigate the transcranial doppler (tcd) changes during the living donor liver transplantation and the association between the tcd changes and the post-transplant neurological complications.

objectives: participants \& setting: intervention \& measurements: sample size:

Eligibility criteria:
inclusion criteria: * all patients scheduled for living donor liver transplantation for whatever the indication at gastrointestinal surgery center (gisc) exclusion criteria: * patients with coexisting neuropsychiatric or cerebrovascular disorders or those who have a history of head trauma or brain surgery
identifying pain generators and potentiators of residual complaints following lumbar discectomy

Conditions: Lumbar Radiculopathy; Central Sensitisation

Summary: lumbar discectomy (i.e. surgically removing a hernia) is frequently performed in belgium to treat lumbar radiculopathy. every year \>12,000 interventions are performed with variable long-term results. the treatment success of this procedure varies and up to 41% of the patients report post-operative persistent pain complaints, and consequently suffer from failed back surgery syndrome (fbss). chronic complaints in fbss following lumbar discectomy are usually treated with symptomatic interventions (including painkillers, neuromodulation, etc), rather than from a biopsychosocial perspective. in order to develop a focused and effective treatment strategy, it is crucial to first gain insight into how persons with persistent complaints after lumbar discectomy differ from those without persistent symptoms. different known contributing factors entail type of surgery, muscle and psychosocial impairments. although in scientific and clinical literature it is assumed that dysfunctional pain processing also plays an important mechanistic role in fbss, there is a lack of research to support this. however, this knowledge is crucial to depict the full mechanistic picture of pain generators and potentiators in fbss. therefore, we will examine whether residual complaints persisting following lumbar discectomy can be accounted for by underlying dysfunctional pain processing and whether a clinical classification algorithm can be used to identify the predominant pain mechanism in these patients.


Eligibility criteria:
inclusion criteria: * dutch speaking * body mass index below 35kg/m² * lumbar radiculopathy patients, classified as asa i to ii without any symptoms of spinal cord compression (i.e. bilateral leg pain), who are scheduled for a first-time, single-level, unilateral lumbar discectomy * healthy, pain-free controls (score 0 on a visual analogue scale from 0 to 100) exclusion criteria: * female participants will be excluded if pregnant, lactating or \<1 year postnatal * having (a history) of severe medical disorders either respiratory (e.g. cystic fibrosis), orthopedic (e.g. whiplash trauma), neurologic (e.g. cerebrovascular incident), cardiovascular (e.g. severe hypertension), endocrinological (e.g. diabetes), psychiatric (e.g. post-traumatic stress disorder * having a history of spinal surgery (e.g. discectomy), spinal traumata (e.g. vertebral fracture) or severe spinal deformities (e.g. spondylolisthesis) * having a pacemaker or defibrillator * healthy controls will be excluded if having suffered low back pain in the preceding year of score 2 or higher on the visual analog scale and which limited their activities of daily living or for which they consulted a (para)medic.

Keywords: lumbar radiculopathy discectomy central sensitization
appendectomy during pregnancy and child development

Conditions: Appendicitis Acute; Pregnancy Related; Anesthetic Toxicity; Child Development; Psychomotor Development Impaired

Summary: maternal acute appendicitis during pregnancy is the most common abdominal surgical emergency. long-term neurodevelopmental issues were scarcely reported. the aim of the study is to investigate the impact of appendicitis and appendectomy during pregnancy in general anesthesia on the cognitive and psychomotor development of children.

maternal acute appendicitis (aa) is the most common emergent abdominal surgical condition during pregnancy. brain development in a fetus is dynamic and complex, and therefore much more vulnerable to different agents. gastrointestinal operations during pregnancy are performed in general anesthesia and anesthetic neurotoxicity in the developing brain, through the period from a fetus to a child, delivered inconsistent results. child development after aa or other intra-abdominal inflammatory/infective condition during pregnancy was not consistently reported or studied. in most reports, the length of fetal follow-up after appendectomy for aa during pregnancy is not defined, not stated, or declared as 'uneventful'. investigators will make a study with a structured children's cognitive and neurodevelopmental follow-up whose mothers had operated acute appendicitis during pregnancy.

Eligibility criteria:
inclusion criteria: * all pregnant women operated for acute appendicitis (january 2006- december 2020) exclusion criteria: * pregnant women younger than 18 * nonpregnant women

Keywords: appendicitis, pregnancy, child development, psychomotor development impaired
ability of hypotension prediction index to predict hypotension events in thoracic surgery

Conditions: Perioperative/Postoperative Complications

Summary: investigators design this prospective observational study to exam the ability of hypotension prediction index in predicting intraoperative hypotension events in each phase of thoracic surgery

hypotension prediction index is a novel introduced monitoring-tool that aims to predict hypotension events before their occurence, and has been reported to have superior predictive ability than the commonly measured perioperative hemodynamic variables. to date, there is no information regarding its ability to predict hypotension events in each phase of thoracic surgery.

Eligibility criteria:
inclusion criteria: * adults undergoing scheduled vats surgery exclusion criteria: * pregnant women * patients in intensive care units * patients with the underlying disease including respiratory failure(fev1/fvc \< 70 % and fev1 \< 50%), heart failure(nyha score =iii、iv), kidney failure(egfr\< 60 ml.min-1.1.73m-2), liver failure * patients with ongoing infection
change in pain and quality of life following scs for chronic pain

Conditions: Pain, Chronic; Pain, Radiating; Pain, Back; Pain Syndrome

Summary: study title subject-reported treatment efficacy and procedure satisfaction (steps) study.burst study- a prospective observational clinical study examining the changes in quality of life and pain following spinal cord stimulation for the treatment of chronic intractable lower back and lower limb pain.

objectives the primary objective is changes in lower back and/or lower limb pain patient-reported satisfaction with procedure outcome and treatment efficacy to reduce pain levels following an orthopedic procedure for knees, hips, shoulders, elbows, wrists, or anklesspinal cord (scs) stimulation. secondary objectives include changes in physical health, quality of life, and quality of life and pain-related prescription medication usage. design and outcomes this is a prospective observational single-arm study to access the primary outcome variable of lower back and/or lower limb patient satisfaction with procedure outcomes as measured using a modified macnab scale. patients will have presented to their healthcare providers with knee, hip, shoulder, elbow, wrist, or ankle pain and will have elected and been assigned a medically-appropriate surgical procedure as part of their standard of care. it is possible for subjects to have multiple areas of pain and subsequent surgeries, and subjects have the option of completing surveys for all medically-indicatedmedically indicated areas being treated.pain iiintervention and duration there will be no study intervention. subjects will only be monitored and evaluated for pre and post-operative satisfaction, pain, physical activity levels, quality of life, and medication use levels. subjects will be followed for 12 months following their scs stimulation implant procedure. sample size and population investigators aim for a minimum population size of 1,500 in order to give statistical significance with results. subjects will be stratified by surgical procedurearea of chronic pain.

Eligibility criteria:
inclusion criteria: prescribed spinal cord stimulator implant by their healthcare provider. previous conservative care such as physical therapy or chiropractic care that failed to provide adequate pain relief. willing and able to adhere to the protocol of the study including the survey timeline. between the ages of 18-85 years. exclusion criteria: unwilling to sign informed consent and comply with protocol

Keywords: spine lower limb
the fall monty activity programme feasibility study

Conditions: Stroke

Summary: between 45-73% of people who have had a stroke fall over in the months and years following their stroke. falls not only lead to injuries such as broken hips, but they may also lead to fear of falling. as a consequence people can get fearful to walk, keep up their household tasks and their social activities such as visiting friends and family. research has shown that exercises for strength and balance can help both older people and patients after stroke to get fitter and healthier and help to prevent them from having a fall. people also have less falls if they have learned about falls facts and home safety precautions. research has further suggested that people have less fear of falling and less injuries from a fall if they have learned how to fall ('safe landing' strategies). based on these research findings the researchers have developed a new falls prevention programme called the fall monty activity programme (fallmap). this programme aims to aid in functional recovery and reduce falls by combining a mix of activities such as falls education, strength and balance exercises, and activities that teach people how to get up from the floor and how to fall safely. especially because people with residual impairments following a stroke have an increased risk of a fall, the feasibility of this programme will be tested in a small group of people after stroke first. this study is a first step in establishing whether the different components of the fallmap are acceptable and practical for both patients after stroke and staff who deliver the program. in particular, it is important to evaluate if it is feasible to provide the seven combined components as one comprehensive programme. secondly, the question whether participating in the programme can positively influence the participants' fear of falling, quality of life, leg strength, balance and mobility will be explored. if this feasibility study suggests the programme can work in the clinical setting, then a definitive randomised controlled trial will be proposed in order to look at whether the full programme is effective at reducing falls in patients after stroke.


Eligibility criteria:
inclusion criteria: * aged over 50 and more than 6 months post-stroke. * living in the community. * having a good cognition (≥ 25 points on the short mini-mental state examination). * able to walk at least three times weekly outside the home without hands-on supervision (with or without the use of a walking aid). exclusion criteria: * the presence of medical issues preventing someone from participating in moderate to vigorous strength and balance exercises. * a receptive aphasia impacting on ability to follow instructions. * the inability to provide informed consent.

Keywords: falls