Kornimate/medical-research-clean huggingface dataset:
minimal invasive treatment of achilles tendinopathy: focus on percutaneous release (maffulli)

Conditions: Tendinopathy

Summary: to evaluate the outcome of percutaneous paratenon release for chronic midportion achilles tendinopathy.

since 2011 the percutaneous procedure took the place of the open release of the paratenon for the surgical treatment for chronic midportion achilles tendinopathy in the investigators' center. in this study the investigators re-evaluate the patients undergoing percutaneous surgery since then in order to compare the outcome with the excellent results cited in literature. the patients will be contacted and asked to participate completing a vas-score, a visa-a score and agreeing with a clinical examination. approving by the ethical committee of uzleuven is pending.

Eligibility criteria:
inclusion criteria: * patients that underwent percutaneous paratenon release for chronic midportion achilles tendinopathy exclusion criteria: * insertional tendinopathy * open intervention * (partial) achilles tendon rupture

Keywords: chronic midportion achilles tendinopathy percutaneous paratenon release
safety and immunogenicity of oxford astrazeneca vaccine against covid-19 infection

Conditions: Vaccine Adverse Reaction; Seroconversion

Summary: after sars-cov-2 inactivated vaccine authorization for use in different countries including egypt, investigating its immunogenicity, safety, and efficacy in preventing covid-19 infection is highly needed. in egypt, immunization of hcws in isolation hospitals by sars-cov-2 inactivated vaccine is now a national priority. moreover, data and reports regarding the application of vaccine are still limited and deficient.

this study will be conducted at zagazig university hospital. laboratory work will be implemented at immunology research laboratory at microbiology and immunology department, faculty of medicine, zagazig university. a representative sample will be drawn from healthcare workers (hcws) at zagazig university hospital. assessment of inclusion and exclusion criteria by history taking. blood samples will be drawn from hcws by direct venipuncture before the start of immunization and 14 days after immunization. the incidence of any adverse reactions after each immunization will be recorded. sars-cov-2 neutralizing antibodies will be detected by enzyme-linked immunosorbent assay.

Eligibility criteria:
inclusion criteria: -healthy healthcare workers exclusion criteria: * healthy healthcare workers' refusal. * pregnancy and lactation. * confirmed acute cases of sars-cov-2 infection * having a history of sars-cov-2 infection in the past 3 months. * fever (body temperature \> 37.0 ℃), dry cough, fatigue, nasal obstruction, runny nose, pharyngeal pain, myalgia, diarrhea, shortness of breath and dyspnea occurred within 14 days before vaccination. * history of allergy to any vaccines * previous vaccination within the last 30 days
simo decoction and acupuncture on poi in colorectal cancer

Conditions: Colorectal Cancer

Summary: colorectal cancer resection is one of the most common types of abdominal surgery. though most patients undergoing colorectal resection show recovery of bowel movements within a week, some have prolonged intestinal paralysis or postoperative ileus, resulting in decreasing patient comfort, increasing morbidity and mortality, a longer hospital stay and subsequent increased healthcare costs.

prevention the incidence of postoperative ileus (poi) is quite important because of the negative clinical outcomes it causes. in the past two decades, many treatments and care approaches, such as fluid restriction, early enteral nutrition, and nonsteroidal anti-inflammatory drug are used for the management of poi. in theory of traditional chinese medicine, oral simo decoction (smd) or acupuncture at the tsusanli acupoint can boost gastrointestinal hypomotility. the efficacy of accelerating the return of gastrointestinal function by such single method or combination of them has been validated in randomized controlled trials and systematic review following several types of surgery. in recent years, chewing gum, a new and simple modality, has become a commonly applied method in order to prevent and reduce the poi. systematic reviews and meta-analyses revealed that chewing gum provided significant benefits for the improvement of postoperative bowel function. more importantly, many official guidelines recommend chewing gum for an evidence-based approach in the prevention of poi. despite these positive evidence, three newest randomized controlled trials are unable to demonstrate an effect of chewing gum on the recovery of bowel function after colorectal resection. it is important to note that almost all previous randomized controlled trials are based on small sample size. this raises the question whether postoperative smd, acupuncture at the tsusanli acupoint, or chewing gum can reduce risk of poi following colorectal resection among patients with large sample size. to examine this question, we conducted this randomized controlled trial to compare incidence of poi and length of hospital stay in colorectal cancer patients who received smd and acupuncture, chewing gum or no intervention following resection.

Eligibility criteria:
inclusion criteria: * underwent open or laparoscopic colorectal cancer resection * diagnosis of colorectal cancer was confirmed by histopathological examination of surgical samples in all patients exclusion criteria: * previously underwent exploratory laparotomy * known central nervous system tumors including metastatic brain disease * history of organ allograft * substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results * any condition that is unstable or which could jeopardize the safety of the patient and his/her compliance in the study * pregnant or breast-feeding patients
unloading induced effects on local glucose uptake into m. soleus

Conditions: Local Glucose Uptake; Glucose Metabolism Disorders

Summary: the present study aimed to investigate whether a daily intake of lupin protein and a neuromuscular electrical stimulation training twice a day can improve local glucose uptake into m. soleus during a 60 day unloading phase with a special unloading device, the hephaistos orthosis (hep).

the 60 day unloading intervention with the hephaistos unloading device had the following key objectives: primary hypothesis: * assesment and evaluation of insulin sensitivity and local glucose uptake in the unloaded m. soleus and whether it can be improved by dietary supplementation of lupin seeds and neuromuscular electrical stimulation. secondary hypotheses: * assesment and evaluation of unloading-induced reductions in muscle mass and whether they can be mitigated by dietary supplementation of lupin seed and neuromuscular electrical stimulation. * assesment and evaluation of whole-body glycemic effects of the interventions.

Eligibility criteria:
inclusion criteria: * male volunteers * age: between 20 and 45 years * body mass index (bmi): 20 -26 kg/m2 * agreement and signed consent before the study exclusion criteria: * smoker * competitive athletes * diabetes mellitus * rheumatic disease * muscle or joint disease * bone fractures in the period up to one year before study start * herniated disc * flatfeet (pes planus) * allergy to nuts or legume * vascular diseases * epilepsy * severe hyperlipidemia * anemia (\< hb standard values; standard values healthy men: 13.5 -17.5 g/dl) \* * increased thrombosis risk \* * kidney disorder: deviations from normal values for creatinine in plasma. (normal value: creatinine \< 1.20 mg/dl)\* * lesions of the cruciate ligaments, or orthopedic surgery in the past 10 years on the side of the hephaistos orthosis * achilles tendon injury, or rupture in the past 10 years on the side of the orthosis * hyper-/hypocalcaemia (abnormal levels of calcium in the blood, normal level: 2.15 - 2.64 mmol/l) * intake of anti-inflammatory drugs during the study * abuse of drugs or alcohol (\> than 20-30g alcohol/day) * participation in another clinical study within the last 2 months before the start of this study * increased bleeding tendency (hemophilia, regular use of anticoagulants) * history of intolerance to local anesthetics * imprisoned during study * any other condition classed as unsuitable for study participation by the medical executive director * prior convictions (objectionable criminal record) additional exclusion criteria for mri * metal implants or other osteosynthesis material * pacemaker * claustrophobia

Keywords: lupin protein glucose metabolism glut4 muscle unloading neuromuscular electrical stimulation
improving the quality of care for atrial fibrillation by promoting patient-centered decision making

Conditions: Atrial Fibrillation

Summary: the primary aim of this proposal is to determine the effectiveness of a decision support tool on improving the process of shared decision-making for treatment on nonvalvular atrial fibrillation (nvaf) compared to receipt of usual care.

decision-making regarding appropriate therapy for non-valvular atrial fibrillation (nvaf) is a complex process. different options carry with them different profiles of risks and benefits, and choosing the "right" therapy depends upon the patient's understanding of these risks and benefits and a consideration of the risks and benefits according to the patient's values and preferences. studies have shown that patients' preferred therapy frequently disagrees with what is recommended by disease management guidelines. the purpose of this study is to examine an intervention to improve the quality of decision-making for nvaf compared to usual care. the intervention has several components, including: a) educating the patient about why values and preferences are important to the decision-making process, b) providing an individualized assessment of the risks and benefits of each of the treatment options, c) exploring patients' values and preferences as they relate to the risks and benefits of each of the treatment options, d) preparing the patient to discuss his/her preferences with the physician.

Eligibility criteria:
inclusion criteria: * 45 years or older * be scheduled to see primary doctor at va * diagnosis of atrial fibrillation * english speaking exclusion criteria: * have valvular disease as the cause of afib * be on warfarin for a condition other than nvaf * have a contraindication to warfin * have a contraindication to asa * life expectancy of less than 12 months * cognitive impairment * receiving anti-platelet agent other than aspirin * receiving care in a supervised resident clinic or from an attending physician who refuses participation in the study * bleed with identified source in the last 12 months * bleed with an unidentified source * history of intracerebral hemorrhage * severe hearing impairment * severe visual impairment

Keywords: atrial fibrillation cerebrovascular accident anticoagulation decision-making
the effect of ticagrelor with or without atorvastatin on endothelial function in healthy males

Conditions: Ischemia

Summary: to test the effect of atorvastatin or placebo in combination with ticagrelor on ach-induced vasodilatation of the forearm resistance vasculature as assessed by forearm blood flow (fbf) measurement before and 10 min after a 20 min forearm ischemia. the area under the dose-effect curve (auc) of different ach doses will be calculated and compared between treatment groups (atorvastatin + ticagrelor vs. placebo + ticagrelor) and different time points (pre-ischemia vs. post-ischemia).


Eligibility criteria:
inclusion criteria: * healthy male subjects; 18 - 40 years of age * body mass index between 18 and 27 kg/m2 * written informed consent * normal findings in medical \& bleeding history * non-smoking exclusion criteria: * regular intake of any medication including otc drugs and herbals within 2 weeks before imp administration * known coagulation disorders (e.g. haemophilia, von willebrand´s disease) * known disorders with increased bleeding risk (e.g. peridontosis, haemorrhoids, acute gastritis, peptic ulcer, intestinal ulcer) * known sensitivity to common causes of bleeding (e.g. nasal) * history of thromboembolism * history of occlusive vascular diseases * history of vascular anomalies * history of hypercholesterolemia * history of myopathy * impaired liver function (ast, alt, ggt, bilirubin \> 3 x uln) * impaired renal function (serum creatinine \> 1.3 mg/dl) * elevated creatinine-kinase or serum-myoglobin (\> 3 x uln) * any other relevant deviation from the normal range in clinical chemistry, haematology or urine analysis * hiv-1/2-ab, hbsag or hcv-ab positive serology * systolic blood pressure above 145 mmhg, diastolic blood pressure above 95 mmhg * known allergy against any test agent under study * regular daily consumption of more than on litre of xanthine-containing beverages or more than 40g alcohol * participation in another clinical trial during the preceding 3 weeks
cognitive training and brain stimulation in prodromal alzheimer's disease

Conditions: Subjective Cognitive Decline; Mild Cognitive Impairment

Summary: the aim of this study is to investigate whether a tdcs-accompanied intensive cognitive training of working memory leads to performance improvement in individuals with prodromal alzheimer's disease.

the goal of the present study is to assess behavioral (primary) effects of a multi-session cognitive training combined with transcranial direct current stimulation (tdcs). many studies to date have found tdcs to be an efficient method to enhance various cognitive functions by modulating cortical excitability in young adults, but its behavioral impact and underlying mechanisms in pathological aging still need to be elucidated. individuals with prodromal alzheimer's disease, will participate in a three-week cognitive training with concurrent online tdcs application. cognitive performance (primary) will be examined before, during and after the intervention, in order to draw conclusions about the effect of tdcs. in addition to cognitive training, a control group, receiving sham stimulation during training, will be assessed. follow-up sessions to assess long-term effects are planned four weeks and seven months after the post assessment. furthermore, to assess potential predictors of tdcs effects, functional and structural parameters will be measured with mri. the results of the study will offer valuable insights into efficacy of combined tdcs and cognitive training, as compared to training alone, in individuals with prodromal stages of alzheimer's disease. moreover, improved understanding of tdcs effects on cognitive training performance and underlying neural correlates may help to develop novel approaches for modulating cognitive decline in healthy and pathological aging.

Eligibility criteria:
inclusion criteria: * older adults (60 - 80 years); * right handedness; * subjective cognitive decline (scd) or mild cognitive impairment (mci) exclusion criteria: * dementia or other neurodegenerative neurological disorders; epilepsy or history of seizures; close relatives with epilepsy or history of seizures; previous stroke; * severe and untreated medical conditions that precludes participation in the training, as determined by responsible physician; * history of severe alcoholism or use of drugs; * severe psychiatric disorders such as depression (if not in remission) or psychosis

Keywords: memory brain stimulation
impact of fatigue on jumping performance

Conditions: Healthy

Summary: the purpose of this study will be to determine the effects of a 2-minute single limb lateral step-down fatigue test versus a 30 second side hop test on single limb forward hop distance.

current methods to induce fatigue often incorporate equipment not available in all clinical settings or include tasks that are difficult to standardize. one of the tests to fatigue the leg muscles is the leg extensor fatigue test using a unilateral weight machine. there are drawbacks to this testing including the clinician having access to the equipment, testing only fatigued a single muscle group, and it is less sport/task specific compared to jump testing. our previous work has incorporated the use of a side hop task that is performed by hopping over two lines 40 cm apart for 30 seconds. while this does induce fatigue and decreases single leg forward hop performance the overall decrease was relatively small (\<10 cm). it is likely necessary to induce a greater amount of fatigue; thus further limiting single leg forward hop performance.

Eligibility criteria:
inclusion criteria: * no history of knee surgery * tegner score \>5 exclusion criteria: * participants with traumatic spine or lower extremity injury within past 6 months * participants who are unable to give consent or are unable to understand procedures of experiment

Keywords: side hop forward hop step test vertical jump
antagonization of heparin with protamine sulfate after tavi

Conditions: Aortic Valve Stenosis; Heart Valve Diseases

Summary: transcatheter aortic valve replacement (tavr) is now the first therapeutic option offered to high and intermediate risk patients with symptomatic aortic stenosis but even to low-risk, when the aortic valve is tricuspid and the transfemoral approach is suitable. vascular and bleeding complications are the most frequent procedure-related unwanted events associated with increased short-term morbidity and mortality. selection of the appropriate vascular access site and pre-closing devices as well as stent implantation mitigate these complications. act-guided heparin reaching a target of 300 seconds or more is recommended prior to the placement of the guiding sheath in the common femoral artery. protamine sulfate is the heparin antidote, which antagonizes 100% of its anti-iia activity and 60% of its anti-xa activity. reversal of heparin using protamine sulfate is recommended for transapical and complicated transfemoral aortic valve placement.however, there is a great heterogeneity of protamine use in daily practice and supportive evidence for the prevention of bleeding complications as well as its safety is lacking. in addition, the radial approach for the second vascular access is more commonly used as well as the use of echo-guided femoral puncture further questioning reversal of heparin when the procedure has been successfully completed without overt bleeding complications. our study aims to demonstrate the superiority of a strategy of systematic act-guided heparin administration followed by systematic antagonization with protamine sulfate over usual of care to reduce in-hospital mortality, vascular/bleeding complications, stroke and transcient ischemic attack, myocardial infarction or red blood cell transfusion, from randomization to hospital discharge


Eligibility criteria:
inclusion criteria: * men and women ≥18 years of age * any patient eligible for transfemoral tavi, irrespective of the chronic antithrombotic treatment * written informed consent * registered at the french social healthcare exclusion criteria: * any major protamine sulfate exposure contraindications defined as a history of severe pulmonary hypertension, acute pulmonary edema or history of bronchospasm related to protamine sulfate administration * known allergy to protamine sulfate * hypersensitivity to protamine sulfate including protamine contained as an excipient in nph \[neutral protamine hagedorn\] insulin, known protamine or protamine-heparine complex antibodies * non-femoral approach for the tavi procedure * protamine sulfate exposure within 24h of randomization * fish allergy * mechanical valves * for men: sterile or vasectomy * women of childbearing potential * pregnancy and breast feeding women * contemporaneous enrolment in an interventional clinical trial * patient under guardianship or curatorship

Keywords: tavi protamine heparine antagonization aortic stenosis
efficacy of buprenorphine on postoperative endodontic analgesia

Conditions: Postoperative Pain

Summary: to see whether the addition of buprenorphone to local anesthesia will lengthen postoperative analgesia for endodontic pain


Eligibility criteria:
inclusion criteria: * persons with preoperative pain to percussion of a tooth with pulpal disease requiring endodontic therapy, healthy individuals, asa class i and ii, no known allergies to the drugs being administered exclusion criteria: * pregnancy, allergy to buprenorphine, allergy to local anesthetic

Keywords: analgesia endodontic postoperative
multiple dose study of pf-05231023 in adult subjects who have poor lipid control with and without type 2 diabetes mellitus

Conditions: Diabetes Melliuts, Type 2

Summary: this is a trial in obese subjects who have poor lipid control with and without type 2 diabetes mellitus to study the safety, tolerability and pharmacokinetics of multiple doses of pf-05231023


Eligibility criteria:
inclusion criteria: * male and female subjects of non-childbearing potential between the ages of 30 and 70 years with and without a diagnosis of type 2 diabetes mellitus (according to the american diabetes association guidelines). * subjects with poor lipid control as confirmed by laboratory tests. * bmi of 30 to 40 kg/m2 and a total body weight of \>50 kg (110 lbs). exclusion criteria: * evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding asymptomatic, seasonal allergies at time of dosing). * levels of blood enzymes indicating pancreatitis or elevated liver function enzymes outside of the laboratory's reference range as confirmed by laboratory tests. * subjects with type 1 diabetes mellitus.

Keywords: type 2 diabetes safety multiple dose intravenous
biological imaging guided antalgic radiotherapy of bone metastases (phase ii trial)

Conditions: Bone Metastases

Summary: highly selective irradiation requires accurate target definition by high-resolution three-dimensional imaging. co-registration of fdg-pet and high-resolution ct might be the imaging modality of choice. this choice might target radiation therapy precisely to the intra-osseous volume that is responsible for pain and to spare selectively healthy bone in the vicinity of the metastasis. this strategy could result in equal anti-pain efficacy as conventional large volume radiotherapy, but could allow bone remodeling and preservation of bone structural strength in the vicinity and could lead to reduced toxicity to neighboring organs.


Eligibility criteria:
inclusion criteria: * painful bone metastasis of solid tumors * a maximum number of bone metastases less or equal to 3 * life expectancy \> 6 months * minimum age 21 years * signed informed consent exclusion criteria: * previous radiotherapy to the painful site * bone metastasis from malignant melanoma or renal cell carcinoma * associated fracture or extra-osseous component