Kornimate/medical-research-clean huggingface dataset:
correlation of cardiac computed tomography angiography dimensions and ethnicity in trinidad

Conditions: Coronary Artery Disease

Summary: the aim of this study is to compare coronary artery dimensions on cardiac ct angiography amongst different ethnicities in trinidad.

the aim of this study is to compare coronary artery dimensions on cardiac ct angiography amongst different ethnicities in trinidad.

Eligibility criteria:
inclusion criteria: 1. ccta for chest pain 2. all ethnicities 3. all genders exclusion criteria: 1. patients who did not provide consent.
a simplified questionnaire to detect osa in copd patients

Conditions: OSA; COPD

Summary: to detect the existence of severe obstructive sleep apnea (osa) in chronic obstructive pulmonary disease (copd) patients, which had higher mortality and hospitalization rate, a simplified questionnaire was developed for identifying those copd patients with severe osa.

to detect the existence of severe obstructive sleep apnea (osa) in chronic obstructive pulmonary disease (copd) patients, which had higher mortality and hospitalization rate, a simplified questionnaire was developed for identifying those copd patients with severe osa. with patient's bmi, neck and waist circumference, snores, witnessed apnea... time frame suspect to enroll 5 patients in 1 month and complete 4 patients at least we need 24 months to complete 120 patients

Eligibility criteria:
inclusion criteria: * stable copd patients exclusion criteria: * cancer exacerbation in recent 2 months pregnancy central type sleep apnea claustrophobia chronic respiratory failure
evaluation of a collaborative intervention to promote employer contact and rtw among people with cmd or chronic pain

Conditions: Pain, Chronic; Mental Disorder

Summary: the overall aim of this cluster ranomized controlled trial is to investigate whether an intervention for collaboration between patient with cmd or chronic pain and employer (the demand and ability protocol) can contribute to reduced sick leave and to increased health, work ability and trust in the managers. the intervention is delivered by rehabiliation coordinators at primary health care centres.

the overall aim of this cluster ranomized controlled trial is to investigate whether an intervention for collaboration between patient with cmd or chronic pain and employer (the demand and ability protocol) can contribute to reduced sick leave and to increased health, work ability and trust in the managers. the intervention is delivered by rehabilitation coordinators at primary health care centres. furthermore, the aim is to identify hindering and facilitating factors for feasibility, usability and implementation of the demand and ability protocol intervention (dap) in primary health care. research questions: 1. what is the effect of dap for patients regarding sick leave, health, work ability, and trust in the manager compared to matched controls who do not recieve dap? 2. how do patients and managers experience their participation in the intervention and how do they experience the usability of the dap? 3. what facilitating and hindering factors exist for the introduction and implementation of dap in primary health care, and how do rehabilitation coordinators (reko) and medical doctors experience the feasibility and usability of the intervention?

Eligibility criteria:
inclusion criteria: * have a diagnosis of cmd and/or chronic pain * have a job * be on full-time or part time sick leave * accept the manager's involvement. exclusion criteria: * been on full-time sick leave for more than 6 months before the first contact with reko
effect of amantadine administration on spatial functioning following traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: amantadine hydrochloride is one of the drugs given at rehabilitation programs to people who suffered acquired brain injury in order to expedite recovery and improve functioning. a previous study examined the spatially asymmetric allocation of attention in patients with traumatic brain injury (tbi). patients demonstrated significantly worse performance with leftward than with rightward cross-hemi field shifts of attention. this is reminiscence of neglect patients. this difference was significantly reduced during and following treatment. our objective is to investigate whether amantadine hydrochloride is effective in improving allocation of spatial attention and improving function in people with traumatic brain injury.


Eligibility criteria:
inclusion criteria: 1. aged 18-50 yrs 2. patients who were diagnosed with a diffuse axonal injury post tbi 3. severity of injury was defined as moderate to severe 4. at least 3 months post injury 5. sufficient cognitive abilities to learn and perform the computerised task. exclusion criteria: 1. pyramidal signs on neurological examination 2. localised damage demonstrated on ct 3. contra indication to amantadine, post traumatic epilepsy, renal failure and patients with known sensitivity to amantadine 4. patients who were diagnosed with parkinson's disease or has a first degree family who was diagnosed with parkinson's.

Keywords: amantadine hydrochloride rehabilitation acquired brain injury tbi
effects of stellate ganglion block and superior cervical ganglion block on sleep and recovery

Conditions: PTSD

Summary: the aim of this study is to discover whether the stellate ganglion block (sgb) plus the superior cervical ganglion block (scgb) procedure is associated with improvements in heart rate variability and sleep quality as measured by the whoop biometric capture device. it is predicted that after receiving the blocks, patients will show objectively improved measures of stress in the form of higher heart rate variability and improved sleep quality as well as improved subjective wellbeing.

ptsd is meaningfully related to workforce productivity and quality of life factors, including loss of employment and decreases in general life satisfaction. trauma leads to symptoms that diminish capacity to experience warm and loving feelings for others (emotional numbness), profound negative changes in our self-image and identity, fears that often limit enjoyment of pleasurable activities, and other life-altering challenges. many survivors experience recurrent feelings of helplessness and horror, and may commonly experience crippling panic attacks, feelings of self-blame and shame, chronically disrupted sleep, and relationship conflict with loved ones. low resting heart rate variability (hrv)-- the variability in the time in between heart beats--is a physiological indicator of stress and has been associated with reductions in wellbeing and increases in all-cause mortality. higher heart rate variability is associated with better sleep quality while lower heart rate variability is associated with increased chronic inflammation. the negative effects of ptsd on sleep are well-documented, and interventions are often targeted at alleviating this damaging consequence, as insufficient sleep can perpetuate anxiety and impair day-to-day functioning, leading to an overall reduced quality of life. the current standard of care is to offer a combination of trauma-focused psychotherapy and symptom-focused medications, typically a selective serotonin reuptake inhibitor medication. however, a promising treatment known as the stellate ganglion block (sgb) plus the superior cervical ganglion block (scgb) procedure has been shown to alleviate ptsd symptoms without any of the side-effects and barriers known to patients on conventional treatments. while this treatment shows promise, most of the research performed so far has used subjective self-report measures of sleep quality and stress. whoop biometric capture devices offer an opportunity to objectively measure sleep quality and heart rate variability to investigate the effects of the sgb. physiological data could reveal whether this treatment works not just to alleviate subjective stress, but to physically reduce the effects of ptsd on the body.

Eligibility criteria:
inclusion criteria: - ptsd symptoms exclusion criteria: * none

Keywords: ptsd
supine daoyin in the treatment of aecopd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study was to evaluate the clinical efficacy and safety of supine daoyin in the treatment of aecopd.

chronic obstructive pulmonary disease (copd) is a chronic progressive disease with high incidence rate, high mortality rate and high disability rate. among the people over 40, the prevalence rate is 10.1%, while the prevalence rate in china is 13.7%. acute exacerbation of chronic obstructive pulmonary disease (aecopd) is a major event that affects the natural course of copd. in particular, most patients with aecopd have poor prognosis, higher morbidity and mortality, and lower quality of life. pulmonary rehabilitation can improve the clinical symptoms of aecopd patients, increase exercise tolerance, delay the decline of lung function, and improve the quality of life. in recent years, the clinical research on the rehabilitation of patients with aecopd is still in the exploratory stage, which needs to be supported by clear evidence. this is a multicenter, randomized controlled trial to evaluate the clinical efficacy and safety of supine daoyin in the treatment of aecopd. after admission, the patients were randomly divided into two groups, rehabilitation group and control group, 114 cases in each group. after routine treatment, the patients began to recover when they reached the initial rehabilitation standard, and recovered until they reached the discharge standard. the primary outcomes are the length of hospital stay due to acute exacerbation and clinical symptom score. the secondary outcomes include activities of daily living, dyspnea score, 6-minute walking distance, lower limb muscle strength, mechanical ventilation and quality of life. safety will also be assessed.

Eligibility criteria:
inclusion criteria: 1. a confirmed diagnosis of aecopd. 2. age between 40 and 80 years. 3. mmrc score ≥ 3. 4. barthel index\<50. 5. with the informed consent signed. exclusion criteria: 1. patients with severe cognitive impairment, dementia and various psychosis. 2. combined with severe arthritis and other osteoarthritis affecting the movement. 3. dyskinesia due to neuromuscular diseases. 4. long term bedridden for various reasons. 5. participating in other trials.

Keywords: chronic obstructive pulmonary disease acute exacerbation pulmonary rehabilitation supine daoyin randomized controlled trail
nebulized albuterol for congestive heart failure exacerbation

Conditions: Congestive Heart Failure

Summary: this is a randomized trial of the use of albuterol in the setting of acute decompensated congestive heart failure with radiographic evidence of cardiogenic pulmonary edema.

the objective is to carry out a randomized blinded placebo-controlled trial of inhaled albuterol as an early therapy for patients with decompensated congestive heart failure. compared to placebo, inhaled albuterol will improve oxygenation and decrease the need for non-invasive ventilation in patients with cardiogenic pulmonary edema.

Eligibility criteria:
inclusion criteria: * age 18-65 with shortness of breath and history of chf * pulmonary edema on chest xr exclusion criteria: * pregnancy * clinical or ekg changes to suggest acute coronary syndrome * history of copd or asthma * history of albuterol on medication list

Keywords: albuterol
effects of chiropractic care in patients with hip osteoarthritis

Conditions: Hip Osteoarthritis

Summary: the purpose of the study is to explore the short term effects of chiropractic care on pain and function in patients with hip osteoarthritis.

research over the last years have reported a scarce of trails investigating chiropractic treatment of lower extremities. osteoarthritis, also called joint failure, is a common rheumatic joint disease often affecting the hipjoint, contributing to pain, decreased mobility and loss of function. individuals with osteoarthritis can also be affected in many other ways, e.g. economically, socially and emotionally. chiropractic care may be considered as a complement to the conventional allopathic treatment of hip osteoarthritis. joint manipulation is a well-established treatment technique to restore optimal joint function of the locomotor system. the aim of the study is to explore the effects of chiropractic vs. continued conventional care (waiting list controls) on pain and function during a three week trail period among patients with hip osteoarthritis waiting for arthroplasty.

Eligibility criteria:
inclusion criteria: * waiting for first time unilateral arthroplasty on the affected side exclusion criteria: * documented osteoporosis, current pathology such as malignancy, infection, cardiovascular disease, stroke and femoral fractures on affected side

Keywords: chiropractic hip osteoarthritis hip arthroplasty pain activities of daily living.
a research study of the effect of food on etavopivat in healthy participants

Conditions: Healthy Volunteers Sickle Cell Disease, Thalassemia

Summary: the purpose of this study is to evaluate the effect of food on the amount of etavopivat in the bloodstream of healthy participants. participants will take a single oral dose of etavopivat following a high-fat meal (i.e. fed) and on an empty stomach (i.e fasted) on two separate occasions.the study will last up to 50 days (including screening).


Eligibility criteria:
inclusion criteria: * male or female. * age 18-55 years (both inclusive) at the time of signing the informed consent. * body mass index (bmi) between 18.5 and 39.9 kilogram per meter square (kg/m\^2) (both inclusive) at screening. * body weight greater than or equal to (≥) 40.0 kilogram (kg) at screening. * considered to be generally healthy based on the medical history, physical examination and the results of vital signs, electrocardiogram (ecg) and clinical laboratory tests performed during the screening visit, as judged by the investigator. exclusion criteria: * female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using adequate contraceptive methods. * participation (i.e., signed informed consent) in any other interventional clinical study within 30 days or 5 times the half-life of the previous investigational medicinal product (imp) (if known), whichever is longer before screening. * any disorder, unwillingness or inability, which in the investigator's opinion might jeopardise the participant's safety or compliance with the protocol. * use of tobacco and nicotine products, defined as any of the below: * has used any product containing tobacco or nicotine within 90 days prior to screening, * unable or unwilling to refrain from the use of any product containing tobacco or nicotine throughout the study, * positive nicotine test at screening. * participant is unable to refrain from or anticipates the use of any drug known to be a moderate or strong inhibitor or inducer of uridine 5'-diphospho-glucuronosyltransferase (ugt) enzymes, cytochrome p450 (cyp) 3a4, cyp2c9 or permeability glycoprotein (p-gp), including st. john's wort, for 28 days prior to dosing and throughout the study. * participant is unable to refrain from or anticipate the use of any medications or substances prohibited in the study.
observational study of synovian® inj. in patients with osteoarthritis in the knee

Conditions: Osteoarthritis in the Knee

Summary: this is an observational study to evaluate the injection site reactions of synovian® inj. in patients with osteoarthritis in the knee


Eligibility criteria:
inclusion criteria: * adult male or female patient of over 19 years of age * a patient diagnosed with knee osteoarthritis * a patient who has been informed of the purpose, method of the study and signed the written informed consent form. exclusion criteria: * a patient who shows hypersensitive reaction to the synovian® inj. or to the ingredients of synovian® inj. * a patient with infection at the joint * a patient with skin infection or skin disease at the injection area * a patient diagnosed with osteoarthritis with the kellgren \& lawrence grade iv in x-ray within 12 months before enrollment of this study.
effects of breathing exercises on pain, fatigue, and anxiety levels in women receiving brachytherapy

Conditions: Exercise

Summary: breathing exercises are one of the most useful techniques to reduce stress and anxiety. the aim of this study is to determine the effects of breathing exercises on pain, anxiety and fatigue in patients receiving brachytherapy treatment.

introduction: breathing exercises are one of the most useful techniques to reduce stress and anxiety. objective: the aim of this study is to determine the effects of breathing exercises on pain, anxiety and fatigue in patients receiving brachytherapy treatment. method: the sample of the study will consist of 56 women who applied to the brachytherapy unit of a training and research hospital. the research data will be collected using the introductory information form, numerical pain scale, beck anxiety inventory and piper fatigue scale. although studies have been conducted in different areas regarding breathing exercises, no study has been found in our country regarding the effects of breathing exercises on patients receiving brachytherapy. therefore, this study will determine the effects of breathing exercises on pain, anxiety and fatigue in patients receiving brachytherapy treatment and contribute to the literature. conclusion: it is thought that breathing exercises will be beneficial in reducing physical and psychological symptoms.

Eligibility criteria:
inclusion criteria: * being over 18 years old * being willing to participate in the study * being able to speak and understand turkish exclusion criteria: * having a malignancy related to the respiratory system (bronchus or lung) * having chest pain * having done box breathing and diaphragm breathing exercises/receiving training before * having cognitive dysfunction * not giving consent to participate in the study

Keywords: radiothreapy
particulate corticosteroid versus non-particulate corticosteroid for sacroiliac joint injection

Conditions: Sacro-Iliac Spondylosis

Summary: comparing two different corticosteroids (dexamethasone and triamcinolone) for use in sacroiliac joint injections

patients eligible for a sacroiliac joint injection will be randomized to receive one of two different steroids, dexamethasone or triamcinolone. the response immediately after injection will be assessed to confirm the diagnosis, and then they will be followed for three month to assess the degree of pain relief experienced

Eligibility criteria:
inclusion criteria: * aged \>18, capable of understanding and providing consent in english, capable of complying with the outcome instruments used, capable of attending all planned follow up visits * unilateral low back/buttocks pain of at least 2 weeks. * patient reported 7 day average of numeric pain rating score (nprs) low back/buttocks pain of at least 5/10 at baseline evaluation * clinical diagnosis of sacroiliac joint pain as diagnosed by a board certified physiatrist including history of low back/buttocks pain and at least 2 positive physical exam findings (including positive fortin finger sign, pain with palpation of posterior superior iliac spine, positive faber's test, positive gaenslan's test, positive sacral distraction, positive thigh thrust, positive lateral compression, positive sacral thrust) * patient consents to sacroiliac joint corticosteroid injection in a shared decision-making process with the treating physician. * 80% or more relief of index pain within first 5-15 minutes after injection exclusion criteria: * clinical suspicion of alternative process is greater than clinical suspicion of sacroiliac joint pain * those receiving remuneration for their pain treatment (e.g., disability, worker's compensation). * those involved in active litigation relevant to their pain. * those unable to read english and complete the assessment instruments. * those unable to attend follow up appointments * the patient is incarcerated. * history of prior sacroiliac joint fusion * progressive lower extremity neurologic deficit (from active radiculopathy, unhealed radiculopathy, or neuromuscular disease) * sacroiliac joint steroid injection within the prior 12 months * 2 positive lumbar medial branch blocks within the past 12 months * radiofrequency ablation of the lumbar spine within the past 12 months * lumbar facet steroid injections within the past 12 months * prior epidural steroid injection within the prior 3 months in any location within the spine. * possible pregnancy or other reason that precludes the use of fluoroscopy. * allergy to steroid, contrast media, or local anesthetics. * bmi\>40. * systemic inflammatory arthritis (e.g., rheumatoid arthritis, ankylosing spondylitis, lupus). * active infection or treatment of infection with antibiotics within the past 7 days. * medical conditions causing significant functional disability (e.g., stroke, decompensated copd, decompensated heart failure) * chronic widespread pain or somatoform disorder (e.g. fibromyalgia). * addictive behavior, severe clinical depression, or psychotic features.
effects of a progestin on frequent and/or prolonged bleeding with nexplanon™

Conditions: Birth Control; Contraception; Implant; Breakthrough Bleeding; Uterine Bleeding

Summary: effects of norethindrone acetate (nta) in patients with nexplanon.

the purpose of this study is to find out what effects norethindrone acetate (nta) has on the duration and recurrence of frequent and/or prolonged bleeding associated with nexplanon™.

Eligibility criteria:
inclusion criteria: * between the ages of 18-48 * between ages of 14-17 with parental/guardian permission * women desiring placement of nexplanon™ * willing to keep a daily symptom calendar * keep appointments * women not desiring to become pregnant in the next 2 years exclusion criteria: * known or suspected pregnancy * less than 8weeks postpartum * menarche less than two years ago * current or past history of thrombosis or thromboembolic disorders * hepatic tumors (benign or malignant) * active liver disease * undiagnosed abnormal genital bleeding * undiagnosed headaches * known or suspected carcinoma of the breast or personal history of breast cancer * hypersensitivity to any of the components in nexplanon™ * bmi greater than 40 * depomedroxyprogesterone acetate injection in the previous 12 weeks

Keywords: uterine hemorrhage norethindrone acetate contraceptives