Kornimate/medical-research-clean huggingface dataset:
opioid-free anesthesia in gynecologic surgery

Conditions: Gynecologic Disease

Summary: post-operative nausea and vomiting (ponv) is common for the patients undergoing laparoscopic gynecologic surgery. ponv is a major factor for patient dissatisfaction, delayed patient recovery and increased medical expenses. opioid-reducing anesthetic regimen is known to decrease ponv and facilitate early recovery after surgery (eras) and has been widely accepted recently. in this study, the researchers intend to investigate whether opioid-free anesthesia effectively reduces ponv, and whether it is clinically safe and feasible.


Eligibility criteria:
inclusion criteria: * patients scheduled for laparoscopic gynecologic surgery (≥90 min) for benign or malignant uterine/ovarian disease * age ≥ 19 * asa (american society of anesthesiologists) class i-ii exclusion criteria: * uncontrolled hypertension * untreated intracranial aneurysm * severely impaired renal or hepatic function * pregnancy * history of hypersensitivity for drugs used in the study * patients not using nsaid-containing iv pca (patient controlled analgesia) device post-operatively

Keywords: analgesics, opioid postoperative nausea laparoscopy gynecologic surgical procedures
a dose finding study of pf-00489791 in patients with mild to moderate high blood pressure

Conditions: Hypertension

Summary: the purpose of this study is to evaluate the safety and blood pressure lowering effect of different doses of pf-00489791 in patients with mild to moderate high blood pressure


Eligibility criteria:
inclusion criteria: 1. males and/or females of non-childbearing potential between 18 and 70 years of age 2. history of mild to moderate hypertension exclusion criteria: 1. type 1 or 2 diabetes on prescribed medications 2. secondary, severe, or malignant hypertension 3. history of a significant cardiovascular event within the last 12 months of enrollment

Keywords: clinical trial randomized controlled trial humans cyclic nucleotide phosphodiesterases type 5
weight management intervention in college: a pilot study

Conditions: Obesity

Summary: this proof-of-concept study consists of a series of uncontrolled pilot studies to refine a behavioral weight loss trial using a "small change" approach for emerging adult college students with overweight/obesity. the primary aim of this study is maximize student acceptability of the intervention and weight loss outcomes.

forty percent of emerging adults (age 18-25) have overweight or obesity, which is unlikely to remit and has significant health consequences. however, emerging adults are underrepresented in traditional weight loss programs, drop-out at high rates, and have blunted weight loss outcomes. one potential way to improve participation is to offer bwlis in college health service centers to reduce barriers to participation. approximately 40% of emerging adults are enrolled in a postsecondary institution and college health centers are used widely by students. moreover, delivering an intervention with design features that are responsive to emerging adult preferences and lifestyles may also improve intervention effectiveness and attractiveness. the "small change" (sc) approach to weight loss addresses emerging adult barriers to engagement by focusing on reducing calories through a few self-selected, specific changes to current obesogenic behaviors, requiring less time and effort than traditional behavioral weight loss interventions (bwli) and promoting autonomy and self-efficacy. the sc approach has been used effectively for weight loss in other populations. this proof-of-concept study is part of a larger study that aims to develop and refine a novel and effective bwli based on a sc approach that is designed for emerging adults and for implementation in college health centers, an accessible care setting. the primary aim of this proof-of-concept study is to iteratively test and refine the intervention to maximize student acceptability and weight loss outcomes.

Eligibility criteria:
inclusion criteria: * bmi of 25 or greater * enrolled at college/university where study will take place * english-speaking exclusion criteria: * history or current diagnosis of anorexia nervosa, bulimia nervosa, or alcohol use disorder (current symptoms also assessed at screening using validated screening questionnaires) * participation in another formal weight loss program * current or recent pregnancy * psychiatric hospitalization in the past 12 months * recent weight loss of 5% body weight or more * history of bariatric surgery * severe food or physical activity restrictions that would interfere with treatment recommendations
trial of a brain preservation diet in preventing cognitive decline in old age hostel residents

Conditions: Cognitive Decline; Dietetic Intake

Summary: dementia is a major cause of disabilities in older people. if the onset of dementia can be delayed by preventive measures, the burden of the disease to the society can be greatly reduced. it is now recognised that dietary factors are related to the incidence of dementia. high intake of vegetables, fruit and fish are protective while high intake of saturated fat and salt (via its effect on blood pressure) are detrimental to risk of dementia. the investigators therefore propose to perform a randomized controlled trial of dietetic interventions in old age hostels in hong kong. twelve old age hostels under the tung wah group will be randomly assigned to intervention or control groups. the intervention group will receive dietetic interventions by 2 weekly small group discussion with the residents, modification of menu and publicity. the daily diet to be implemented consists of the following principles: 1. fresh fruit 2 portions, 2. vegetables 4 portions, 3. fish, 4. white meat, 5. sodium intake \< 100 mmol/l, 6. six glasses of water. in the control group. the dietician will give two health talks and advice on menu only. the primary outcome is the incidence of questionable dementia in those who are normal at baseline and the incidence of dementia in those who have questionable dementia at baseline. the categorisation will be performed by trained research assistant after administering a structured questionnaire. change in mini-mental examination score and sf36 quality of life scores are secondary outcomes. food records over three days for each subject are recorded every three months, to ensure that the brain preservation diet has been adhered to. half of the subjects will be randomly assigned to have blood and urine tests at baseline and at one year, in order to examine the health effects of dieting.


Eligibility criteria:
inclusion criteria: * old age home residents age 75 years or above, cdr\<1 exclusion criteria: * tube fed residents
tae and surgery in patients with peptic ulcer bleeding uncontrolled by endoscopic therapy

Conditions: Peptic Ulcer; Bleeding

Summary: the aim of the study is to compare the outcomes of trans-catheter arterial embolization (tae) and surgery as salvage therapy of peptic ulcer bleeding after failed endoscopic therapy.

the aim of the study is to examine the hypothesis that trans-catheter arterial embolization (tae) is safer than and probably as effective as surgery in the control of bleeding from ulcers after failed endoscopic therapy. patients with major arterial bleeding that cannot be stopped by endoscopic therapy will be randomly assigned to receive immediate tae or surgery. primary outcome will be death within 30 days of randomization. secondary outcomes include recurrent bleeding after assigned treatment, need for additional intervention either in the form of interventional radiology or surgery, and post procedural morbidities.

Eligibility criteria:
inclusion criteria: * patients with bleeding peptic ulcers documented during endoscopic therapy and anyone of the following: * forrest i bleeding that fails to be controlled by therapy during first endoscopy * check endoscopy after clinical re-bleeding of forrest i bleeding * forrest iia or an initial iib but a sizable artery unveiled upon clot elevation in a high risk ulcer defined by: * posterior bulbar duodenal ulcer \> 2cm, or * an angular notch / lesser curve gastric ulcer \> 5cm that fail an attempt at endoscopic therapy together with evidence of a significant bleed (hypotension with sbp \< 90mmhg, fresh hematemesis or hematochezia). exclusion criteria: * refusal to participate in trial * no consent * age \< 18 * pregnancy * moribund patients * patients with terminal malignancy

Keywords: peptic ulcer bleeding uncontrolled by endoscopic therapy.
efficacy study of nifedipine controlled-release tablets (xin ran) to treat mild to moderate essential hypertension

Conditions: Essential Hypertension

Summary: the purpose of this study is to compare nifedipine controlled-release (cr) tablets (xin ran) with nifedipine controlled-release tablets (adalat）in the treatment of mild to moderate essential hypertension.


Eligibility criteria:
inclusion criteria: * voluntarily participate and must sign informed consent form * mild to moderate essential hypertension (sbp 140-179 mmhg and/or dbp 90-109 mmhg) * average dbp measured by 24-hour ambulatory blood pressure monitoring (abpm) ≥80 mmhg exclusion criteria: * secondary hypertension and malignant hypertension * pregnant or nursing women, or patients that cannot guarantee to take effective contraception measures * baseline sbp≥180 mmhg or dbp≥110 mmhg, or patients with cerebral, cardiac or renal complications * have following complications: cerebrovascular accident within 6 months, myocardial infarction or cardiac failure, macroaneurysm or dissecting aneurysm, definite angina, a-v block of grade 2 or higher, sick sinus syndrome, atrial fibrillation or other malignant arrhythmia * clinical significant diseases of heart, lung, liver, kidney and hematologic system or malignant tumors, hiv infection, uncontrolled diabetes (fasting blood glucose ≥7.0 mmol/l, 2-hour postprandial blood glucose ≥7.8 mmol/l) * kock pouch * sever gastrointestinal stenosis * abnormal laboratory values with clinical significance, including serum potassium \ 5.5 mmol/l, glutamic-pyruvic transaminase (alt) or glutamic oxalacetic transaminase (ast) \>2-fold upper limit of normal (uln), cr \>uln * uric acid \>uln with the diagnosis of gout * gastrointestinal abnormalities or surgery that may interfere with drug absorption * hyperthyroidism or hypothyroidism * allergic to any ingredient or metabolite of investigational drug or drugs of similar structure * heavy smokers (\>25 cigarettes every day), alcoholics (\>250 ml liquor every day), drug addicts * psychological diseases, acrasia, cannot express explicitly * patients whose mood may be affected by variations in blood pressure, which in turn increases blood pressure * anxiety disorders, depression or cannot follow study protocol * bmi \>30 * night shift, irregular sleep patterns or insomnia * participate in other clinical trials within 3 months * other conditions that investigators consider unsuitable for participation
skin incisions and wound complication rates for c-sections in obese women

Conditions: Obesity; Infection; Cesarean Section; Surgical Wound

Summary: it is the purpose of this study to evaluate the relationship between a low transverse, vertical midline, and supra-panicular high transverse skin incisions and the rate of wound complications in women with a bmi of 40 or greater undergoing a cesarean section for delivery. so far, the choice of incision for the morbidly obese is based only on case reports. no randomized controlled trials have been done up to date comparing these methods. it is our hope that a high transverse incision will have all of the benefits of a low transverse skin incision, with the added benefit of better exposure offered by a vertical midline incision, without the added increased risk of subjecting the woman to a vertical hysterotomy.


Eligibility criteria:
inclusion criteria: * pre-pregnancy bmi equal or greater than 40 exclusion criteria: * prior cesarean section or laparotomy
serum-derived bovine immunoglobulin effect on mucositis

Conditions: Mucositis

Summary: the purpose of this cancer control clinical research study is to evaluate whether nutritional therapy with serum-derived bovine immunoglobulin/protein isolate (sbi) might reduce mucositis (a condition caused by cancer treatment involving mouth sores, pain and/or bleeding that may cause difficulty eating), improve nutritional status and lessen the symptoms associated with chemo-radiation therapy which may result in quality of life (qol) improvements during the prescribed treatment for cancer therapy.


Eligibility criteria:
inclusion criteria: 1. informed consent obtained and signed 2. male or female at least 18 years of age 3. diagnosed with head, neck, or lung cancer and scheduled to undergo combined chemo-radiation therapy 4. diagnosed with head, neck, or lung cancer with disease stage within the criteria described in 4.0 staging criteria 5. not experiencing diarrhea during the 5 days preceding enrollment, as defined by having less than two unformed bowel movements per day or loose (mushy) or watery stools in the 5 days preceding enrollment. 6. not currently taking anti-diarrheal medications (prescription or over the counter). 7. agrees and is able to take the investigational products or placebo starting from the day of enrollment (approximately 7-14 days prior to beginning chemo-radiation therapy) through 6-7 weeks of chemo-radiation therapy (for a total of 8-9 weeks). exclusion criteria: 1. history of uncontrolled diarrhea during screening. 2. history of irritable bowel syndrome with diarrhea with a normal pattern of more than three bowel movements in a 24 hour period. 3. history of inflammatory bowel disease: ulcerative colitis, crohn's disease, or microscopic colitis. 4. history of active infectious diarrhea and receiving therapy within 10 days of the first dose of study drug or placebo. 5. known allergy or intolerance to beef or soy or any ingredient used in the product 6. history of concurrent intensive chemotherapy within 10 days of the first scheduled dose of study drug or placebo. 7. gastrointestinal surgery or bowel resection that could affect study product absorption (this does not include cholecystectomy or appendectomy). 8. unable to comply with the protocol requirements. 9. any condition that in the opinion of the investigator might interfere with the study objective. 10. women who are pregnant or breastfeeding.
the effectiveness of telerehabilitation in patients with subacromial pain syndrome

Conditions: Subacromial Pain Syndrome

Summary: the main hypothesis of the study is that telerehabilitation is an effective treatment method and it is not inferior than standard physiotherapy.the aim of this study is to evaluate the effectiveness of telerehabilitation in patients with subacromial pain syndrome by comparing it with standard physiotherapy.

subacromial pain syndrome formerly known as subacromial impingement syndrome is the cause of approximately 44% to 65% of pain complaints related to the shoulder. methods such as immobilization, drug therapy, injection techniques, physical therapy modalities and therapeutic exercises, manual therapy, acupuncture and surgery can be used in the treatment of the disease. due to the coronavirus disease 2019 (covid-19) pandemic that started in wuhan province of china in december 2019, the problems in patients' access to hospitals and rehabilitation services caused telerehabilitation to be on the agenda. telerehabilitation can be summarized as the delivery of rehabilitation services to those in need by using communication technologies. this method covers the steps of evaluation, monitoring, prevention, intervention, control, training, and consultation. although there are many studies on the effectiveness of telerehabilitation in the literature, there is no study on the superiority of telerehabilitation, physical therapy under supervision and home exercise program over each other.

Eligibility criteria:
inclusion criteria: * having subacromial pain for at least 2 weeks * positive result of hawkins-kennedy, painful arc or infraspinatus muscle strength tests . * to have internet access and equipment to participate in videoconference . * being literate and not having cognitive dysfunction. exclusion criteria: * positive drop arm test * signs of adhesive capsulitis (restriction in range of motion-especially in abduction and external rotation) * grade 3 or full thickness rotator cuff tear * labral tears and other intraarticular structural pathologies * history of shoulder surgery

Keywords: subacromial pain syndrome subacromial impingementsyndrome telerehabilitation physiotherapy
diabetes genome project: a prospective registry to identify genetic variation among diabetic patients

Conditions: Diabetes Mellitus; Insulin Resistance; Atherosclerosis

Summary: previous scientific research has found multiple genes that affect the risk for developing heart disease or complications during the treatment of heart disease. less is currently known about how patients with heart disease may differ on the basis of other ailments they may have and how these other ailments may affect their treatment and prognosis. for this reason, researchers at the mid america heart institute are conducting this research to find out how genes affect heart disease and recovery following angioplasty. the study will include patients with diabetes in order to determine if their genes are different from patients without diabetes. a total of 1,607 patients were enrolled. there were 2 groups of patients selected for this study. the first group of patients included into the study will be those that are scheduled to have a diagnostic angiogram only. the second group of patients were those that had along with the angiogram a percutaneous transluminal coronary angioplasty, ptca and or the use of a device called a coronary "stent", designed to help prop open the artery and to help avoid collapse. samples for both groups will be stored for 30 years. after this time, all samples will be destroyed. ultimately, we are hopeful that we will identify genes that will identify groups of patients at risk for heart disease.

a single-center prospective registry which enrolled 1,607 patients. following informed consent, patients underwent coronary angiography and/or percutaneous coronary intervention. this project was funded by an institution grant, philanthropy, industry, and a grant from the american diabetes association. the long-term goal is to better understand the biological underpinnings associated with diabetic atherosclerosis and vascular risk attributable to diabetes. all patients also provided informed consent for blood banking. blood samples were collected at baseline (fasting) and in patients undergoing pci (random) at 2,8 and 16 hours following arterial injury. these samples were separated in aliquots of 12 x1000µl, 10x500µl edta plasma, 2x1,000 µl and 20x200 µl of buffy coat (baseline only) and 2x1,000 µl of rbcs (baseline only). this protocol was designed to perform multiple biomarker studies as it avoids multiple freeze thaw cycles. a plaque imaging sub-study using the ivus-vh software platform to characterize plaque tissue enrolled 209 patients.

Eligibility criteria:
inclusion criteria: * male or female gender * diabetes mellitus or no diabetes mellitus * candidate for percutaneous coronary intervention * informed consent

Keywords: diabetes mellitus insulin resistance atherosclerosis
heart rate and initial presentation of cardiovascular diseases (caliber)

Conditions: Abdominal Aortic Aneurysm; Coronary Heart Disease NOS; Unheralded Coronary Death; Intracerebral Haemorrhage; Heart Failure; Ischemic Stroke; Myocardial Infarction; Stroke; Peripheral Arterial Disease; Stable Angina Pectoris; Subarachnoid Haemorrhage; Transient Ischemic Attack; Unstable Angina; Cardiac Arrest, Sudden Cardiac Death

Summary: study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.

this study is part of the caliber (cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the nihr and wellcome trust. the central theme of the caliber research is linkage of the myocardial ischaemia national audit project (minap) with primary care (gprd) and other resources. the overarching aim of caliber is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. caliber has received both ethics approval (ref 09/h0810/16) and ecc approval (ref ecc 2-06(b)/2009 caliber dataset).

Eligibility criteria:
inclusion criteria: * one year prior to study entry (up-to-standard follow-up, cprd quality research standard). * \> 30 years old * have at least a recorded heart rate measurement during the study period exclusion criteria: - evidence of prior atherosclerotic or cardiac disease
dutch version fear-avoidance component scale (facs)

Conditions: Musculoskeletal Pain; Musculoskeletal Pain Disorder; Fear of Pain; Fear of Injury; Low Back Pain, Recurrent; Neck Pain; Shoulder Pain; Knee Pain Chronic; Hip Pain Chronic; PROMs

Summary: chronic musculoskeletal disorders such as low back and neck pain are responsible for an enormous global burden. fear-avoidance (fa) can be a predictor for the transition from subacute to chronic low back pain. in patients with neck pain, those who were less fearful about harming their neck, had higher pain tolerance, which might have a positive impact on their level of disability. a new scale, the fear-avoidance component scale (facs) was developed by neblett, mayer, hartzell, williams and gatchel (2015) to assess fa. it consists of an all-encompassing set of constructs that more effectively deals with all critical issues of the fa concept than current scales do. current scales have been criticized because of following findings: limited construct validity, little evidence on treatment responsiveness, a lack of evidence-based cut-off scores and items being too narrow or too general. the new scale comprehensively assesses all cognitive, emotional and behavioral components related to the updated version of the fa model by combining items of well-known scales in context of the fa model with items on one's perception of victimization and blame related to an injury. a dutch version of the facs is currently lacking. subsequently, the aim of this study is to investigate different psychometric properties of the generated dutch version in patients with musculoskeletal disorders.


Eligibility criteria:
inclusion criteria for all patients * between 18-80 years old * current pain complaint is not surgically treated * not being currently treated by a physiotherapist for pain complaint * dutch language is mother tongue * at least 6 weeks of pain exclusion criteria for all patients * pain from a non-musculoskeletal origin (e.g., tumour) * neurological disease * impaired cognition inclusion criteria for healthy controls * not being disabled due to msk pain based on cut-off per disability questionnaire * between 18-80 years old * dutch language is mother tongue