Kornimate/medical-research-clean huggingface dataset:
a prospective study of the dry eye drink that evaluates hydration and subject's assessment on eye dryness

Conditions: Dry Eye

Summary: a study to assess the effect of the dry eye drink on eye dryness

this is a prospective, non-randomized, comparative study of the dry eye drink by bruder healthcare that evaluates hydration and subject's assessment on eye dryness. subjects will administer the dry eye drink by adding one sachet of the dry eye drink powder in 12 oz of water.

Eligibility criteria:
inclusion criteria: * male and/or female subjects aged between 18 and 65 years (both limits inclusive). * subjects with symptomatic dry eye syndrome confirmed at baseline in at least any one or both the eyes. * subjects with ≥ 310 mosmol/l tear osmolarity. * subjects with ≥ 6 speed score. * subject willing to provide written informed consent and able to comply with protocol requirements. exclusion criteria: * subjects who are pregnant, nursing, or planning a pregnancy within the study participation period. * have undergone mechanical treatment for meibomian gland dysfunction using thermal pulsation/expression (e.g., lipiflow) or intense pulsed light (e.g., optilight) therapy within 6 months prior to the screening/baseline visit * have a known hypersensitivity to any of the study product components * have undergone ocular surgery (e.g., cataract, corneal or refractive surgical procedure) within 6 months prior to the screening/baseline visit * have evidence of clinically significant ocular trauma * have active ocular herpes simplex or herpes zoster infection * have ocular inflammation (uveitis, iritis, scleritis, episcleritis, conjunctivitis or keratitis, with the exception of keratoconjunctivitis sicca) at the discretion of the investigator * have ocular infection (e.g., viral, bacterial, mycobacterial, protozoan or fungal infection of the cornea, conjunctiva, lacrimal gland, lacrimal sac or eyelids. including hordeolum) * have severe (grade 3 or 4) inflammation of the eyelid (e.g., blepharochalasis, staphylococcal blepharitis or seborrheic blepharitis) * have eyelid abnormalities that significantly affect the lid function (e.g., entropion, ectropion, tumor, edema, blepharospasm, lagophthalmos, severe trichiasis, severe ptosis) * have an ocular surface abnormality that may compromise the corneal integrity (e.g., prior chemical burn, recurrent corneal erosion, corneal dystrophy, or the effect of any other ophthalmic medication that might in the opinion of the investigator compromise the ocular surface integrity) * have a systemic condition or disease not stabilized or judged by the investigator to be incompatible with participation in the study or with the lengthier assessments required by the study (e.g., current systemic infection, uncontrolled autoimmune disease, uncontrolled immunodeficiency disease, history of myocardial infarction or heart disease, etc.) * participation in any clinical study within 30 days before the first administration of study product. * subjects who are illiterate and cannot complete the subject diary independently.

Keywords: eye dryness dry eye drink
the effect of oral administration of 9-cis rich powder of the alga dunaliella bardawil on visual functions im patients with retinitis pigmentosa

Conditions: Retinitis Pigmentosa

Summary: retinitis pigmentosa is a genetically determined disease consisting of progressive centripetal retinal degeneration starting in the rods outer segments. its prevalence is 1:4000 people and is the fourth most common blinding disease in israel in 2004 \[7% of all blindness\]. the investigators tried to treat a non-progressive form of the disease \[fundus albipunctatus\] by oral therapy of the food supplement made from alga dunaliella bardawil composed of approximately 50% 9-cis β-carotene. the alga dunaliella bardawil accumulates high concentration of β -carotene when grown under appropriate conditions. the β -carotene of the alga is composed of approximately 50% of all-trans - β carotene and 50% 9-cis β -carotene. the 9-cis β -carotene has shown to be a precursor of 9-cis retinoic acid both in-vitro in human intestinal mucosa and in-vivo in a ferret, perfuse with 9-cis b-carotene. the night vision, as measured objectively by electroretinography (erg) more than doubled in six patients tested. the visual field was also improved significantly.


Eligibility criteria:
inclusion criteria: * written informed consent to participate in the study. * men or women aged 18 years or older. * electroretinogram (erg) responses compatible with the diagnosis of retinitis pigmentosa exclusion criteria: * current smokers. * current use of vitamin a/ beta carotene supplements. * active arterial disease within 3 months of study entry such as unstable angina, myocardial infarction, transient ischemic attack (tia), stroke, and coronary artery bypass graft (cabg) surgery. * history of malignancy, except basal or squamous cell skin carcinoma. * pregnant women, women who are breast feeding, and women of childbearing potential who are not using chemical or mechanical contraception. * uncontrolled hypertension defined as either resting diastolic blood pressure of \>95mmhg (taken from the mean of 3 readings) or resting systolic blood pressure of \> 180 mmhg. * history of alcohol abuse or drug abuse, or both. * patient plans to engage in vigorous exercise or an aggressive diet regimen. * uncontrolled endocrine or metabolic disease. * participation in another investigational drug study within 4 weeks of entry into this study. * serious or unstable medical or psychological condition that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study. * subject whose hormone replacement therapy (hrt) or oral contraceptive therapy (oct) was initiated within the 3 month prior to enrollment.
3d telemedicine: a clinician feedback study

Conditions: Telemedicine; 3 Dimensional; Reconstructive Surgery

Summary: the use of telemedicine has increased significantly due to constraints imposed by the covid pandemic. 3d telemedicine uses multiple cameras in the clinic room which can reconstruct an image in 3 dimensions in real-time, which may be beneficial in more visual focused specialties such as plastic surgery. there are no clinical data regarding the use of 3d telemedicine, with previous studies laboratory based without clinicians or patients. this study aims to provide clinician data comparing 3d and 2d telemedicine, and feedback to allow incremental improvement of the system prior to clinical trials involving patients.

aims the aim of this study is to assess 3d telemedicine and 2d telemedicine from the clinician's perspective, to optimise the system prior to clinical trials with patients. this will provide baseline validated outcome data on areas such as usability, presence (the realism or immersion of a system), mental effort and task load. "keep, lose and change" prompts will be used to aid improvements in the 3d telemedicine system prior to clinical trials. participants this will be a clinician feedback based study on 2d telemedicine and 3d telemedicine. clinicians will include nurses, doctors and physiotherapists from canniesburn plastic surgery unit, glasgow, uk. consent clinicians will consent in writing to participate method clinicians will use both 3d and 2d telemedicine systems to examine a member of the research team who will act as a "patient". there will be a single clinician (consultant, nurse specialist or physiotherapist) examining the patient during the clinic.they will use each system for 10 minutes each. no randomisation will take place. this will be followed by a questionnaire which will be filled in once per patient by the clinician in the clinic. outcome measures no primary or secondary measures are specified as this is an observational feedback study, not an interventional clinical trial. satisfaction - visual analogue scale 0-100 mental effort rating scale - single instrument likert scale (paas 1996) system usability scale - 10 item industry standard technology scale presence questionnaire - 29 item scale - assessment of presence in the system/virtual environment (pq, witmer 2005). semi structured exit interview - will discuss with participant their views on the telemedicine system, using "keep, lose and change" prompts to aid system improvements.

Eligibility criteria:
inclusion criteria: * clinicians in canniesburn plastic surgery unit * doctors * nurses * physiotherapists exclusion criteria: * visual problems whereby participant is legally blind * cannot consent
smile vs. lasik using contoura with phorcides

Conditions: Myopia; Astigmatism

Summary: subjects will undergo smile surgery in one eye and lasik using contoura with phorcides on the contralateral eye to correct myopia.

once consented to participate in the study, subjects will have a comprehensive ocular examination to determine eligibility to undergo simultaneous smile surgery in one eye and lasik using contoura with phorcides on the contralateral eye to correct myopia.the study objective is to compare the 6-month visual outcomes (i.e., visual acuity, contract sensitivity, high order aberrations), quality of vision (i.e., double vision, glare, starburst, halos, etc.) and dry eye symptoms of patients undergoing contralateral lasik using contoura with phorcides and smile surgery. surgical treatment will be randomized so there is a 50% chance to receive smile on the right eye and lasik on the contralateral eye. subjects will receive standard of care topical ophthalmic antibiotic and steroid drops. visual outcomes and patient self-reported symptoms will be assessed at week 2, month 1, month 3, and month 6.

Eligibility criteria:
inclusion criteria: * male and females between the ages of 21 and 50 * nearsightedness between -2.00 diopters and -8.00 diopters * have similar levels of nearsightedness in each eye (≤1.5d of difference between eyes) * less than or equal to 3.00 diopters of astigmatism * have similar levels of astigmatism in each eye (≤0.75d of difference between eyes) * total spherical equivalent (se) of no more than -8.0 d * tricare prime beneficiary * residing within 60 miles radius from lackland afb exclusion criteria: * subjects with corneal abnormal findings including signs of keratoconus, keratoconus suspect, abnormal corneal topography, epithelial basement membrane disease, pellucid marginal degeneration, corneal degenerations, progressive and unstable myopia, irregular or unstable corneal mires on central keratometry images, and patients whose corneal thickness would cause anticipated treatment would violate the posterior 250 microns (μm) of corneal stroma from the corneal endothelium. * subjects with active collagen vascular, connective tissue, autoimmune or immunodeficiency diseases * pregnant or nursing females * systemic disease likely to affect wound healing, such as uncontrolled diabetes and severe atopy * any ocular disease such as advanced/uncontrolled glaucoma, severe dry eye, active eye infection or inflammation, recent herpes eye infection or problems resulting from past infection. * 0.25 or 0.50 of manifest astigmatism in either eye * taking the medication isotretinoin (accutane) or antimetabolites for any medical condition.

Keywords: smile lasik countoura phorcides
role of as-oct in assessment of corneal perforation

Conditions: Corneal Perforation

Summary: assessment of healing of thin and perforated cornea after surgical treatment by anterior segment optical coherence tomography

* thin and perforated cornea (small perforation) is surgically treated by amniotic membrane graft and platelet rich plasma clot * anterior segment optical coherence tomography is performed preoperative and 1 month postoperative to assess healing

Eligibility criteria:
inclusion criteria: * thin cornea about to perforate * small corneal perforation exclusion criteria: * active infection
anti-stigma intervention for chinese american older adults

Conditions: Mood Disorders; Anxiety Disorders

Summary: approximately 50 participants will be enrolled and screened to achieve 45 eligible patients with mood/anxiety disorders to complete a 10 weekly anti-stigma group intervention (asgi) in addition to several self-report internalized stigma and psychiatric measures.this study will examine changes in internalized stigma and psychiatric symptoms pre- and post-asgi with 3 months post-intervention follow-up.


Eligibility criteria:
inclusion criteria: * self-reported chinese heritage; * 55 years or older * mandarin and/or cantonese speaking and ability to read and/or comprehend spoken chinese language. * currently receiving treatment from a mental health provider at gouverneur medical center asian bicultural clinic (gmc abc) and willing to continue mental health care through the study. * willing to provide release for communication between primary mental health care provider and study staff throughout the study. * documented by mental health provider after consent for release of information as having mood and anxiety disorder diagnosis in the past year; * a willingness to participate in the asgi with stated availability; * able and willing to provide informed consent. exclusion criteria: * lifetime psychosis, neurocognitive, or significant neurological disorders; * current manic episode; * past 6 months of alcohol/substance use disorder; * serious safety concerns of suicide or homicide.
curcumin gel on radiation induced oral mucositis

Conditions: Radiation-Induced Mucositis; Head and Neck Cancer

Summary: the goal of this clinical study is to investigate the effect of a curcuma longa oral gel (curenext) on reducing radiation-induced oral mucositis severity in cancer patients and provide a context for understanding if there is a relationship between the curcumin clinical effect and production of egfs and il8. researchers will compare between curcumin group and standard treatment group.


Eligibility criteria:
inclusion criteria: * patients above 16 years having histopathologically confirmed cancer in head and neck region who planned to have radiation with head and neck mask. * scheduled for 6-8 weeks of radiotherapy with 60-70gy radiation (200cgy/fraction for 5 days/week). exclusion criteria: * patient with hodgkin lymphoma. * any allergy to curcumin or other condiments.

Keywords: radiation induced oral mucositis head and neck cancer curcuma longa egf il8
computer assisted early detection of liver metastases from fmri maps

Conditions: Metastatic Colorectal Cancer

Summary: the purpose of this protocol is to develop a detailed mri technique and haemodynamic maps enabling early detection of colorectal metastases in the liver.

in this research, we propose to develop methods and protocols for imaging-based, non-invasive early detection and diagnosis of colon cancer metastases. colon cancer is the third most common cancer worldwide. while it is amenable to surgery if detected early, advanced carcinomas are usually lethal, with liver metastases being the most common cause of death. early and accurate detection of these lesions is recognized as having the potential of improving survival rates and reducing treatment morbidity. current diagnostic imaging offers improved discrimination and sensitivity that can be used for earlier detection of smaller lesions conducive to curative therapy. in previous research, we demonstrated the feasibility of fmri based on hypercapnia and hyperoxia for monitoring changes in liver perfusion and hemodynamics without contrast agent administration. the isolation and analysis of areas with significant hemodynamical changes in images acquired at early phase of tumor development has proven to be a difficult, time consuming, and potentially unreliable task. our goal is thus two-fold: 1. use image processing and machine learning tools on a training set of hemodynamical maps obtained from well validated tumors to automate the process and improve its discrimination and sensitivity characteristics, and; 2. implement our method in patients with colorectal liver metastases. the method can help general radiologists with no image processing training to highlight undetectable tumors from background noise and increase diagnosis specificity and sensitivity.

Eligibility criteria:
inclusion criteria: * control group of healthy volunteers * study group: patients with colon cancer stage iii or iv with high suspicion of liver metastases: raising cea, suspected lesion in the liver by ct or pet. exclusion criteria: * contraindication to perform mri.

Keywords: colon cancer metastatic colorectal cancer mri magnetic resonance imaging early cancer detection medical image processing machine learning disease modeling colon cancer stage iii
a prospective, multicenter, randomized control study to determine clinical effectiveness, patient wellness and cost of pain related care of in-elastic lumbar sacral orthoses versus standard medical treatment in patients presenting with acute low back pain in primary care centers (the arrest study)

Conditions: Back Pain; Low Back Pain

Summary: the objective of this study is to evaluate sixty male and non-pregnant female patients diagnosed with acute moderate to severe low back pain with the onset of symptoms within 30 days. to evaluate functional improvement following a 4-week use of an in-elastic lumbar sacral orthosis (lso) as a treatment modality for acute low back pain.

the objective of this study is to evaluate sixty male and non-pregnant female patients diagnosed with acute moderate to severe low back pain with the onset of symptoms within 30 days. to evaluate functional improvement following a 4-week use of an in-elastic lumbar sacral orthosis (lso) as a treatment modality for acute low back pain.

Eligibility criteria:
* inclusion criteria: o moderate to complete disability (baseline odi score of 21 to 80 percent) * exclusion criteria: * pregnant patients * patients considering pregnancy * patients in any other investigational device or drug study * patients unwilling to return for follow up * patients unwilling to provide access to medical claims associated with pain management.
denosumab treatment in ckd patients at high risk of fracture

Conditions: Chronic Kidney Diseases; Fracture; Bone Density, Low; End Stage Renal Disease

Summary: objective: to verify the efficacy and safety of denosumab in the prevention and treatment of ckd-mbd in ckd patients with high risk of fracture. methods: a cohort of ckd patients with high risk of fracture was established and followed up for long periods (≥24 months). patients with ckd3b-5d stage and fracture risk assessment tool (frax) scores at high risk or very high risk of fracture were enrolled. a multicenter, prospective, open-label, randomised controlled, interventional study was conducted. the patients were divided into two groups. the patients in the denosumab group received subcutaneous injection of denosumab 60mg once every 6 months, and the patients in the non-denosumab group received conventional treatment. bone metabolic markers (serum calcium, phosphorus, vitamin d, parathyroid hormone, alkaline phosphatase, tartrate-resistant acid phosphatase 5b, osteocalcin, total n-terminal propeptide of type i collagen, etc.), bone mineral density (dual-energy x-ray, quantitative ct), and vascular calcification score were regularly monitored. all adverse events (all-cause death, cardiovascular death, cardiac events, fracture, hospitalization, emergency department visits, etc.) were recorded during the follow-up period. bone mineral density and clinical parameters were compared between the two groups.


Eligibility criteria:
inclusion criteria: * ≥18 years old; * stage 3b-5d chronic kidney disease; * the 10-year probability of hip fracture assessed by fracture risk assessment tool (frax) was \>5%; * voluntarily signed informed consent. exclusion criteria: * age \< 18 or ≥100 years; * premenopausal women; * denosumab was absolutely contraindicated; * had received denosumab or bisphosphonates therapy; * tertiary hyperparathyroidism; * patients with malignant tumor; * patients at risk for osteonecrosis of the jaw; * estimated follow-up time ≤12 months.

Keywords: denosumab chronic kidney diseases treatment fracture
fermented grape combined with fruits and vegetables drink on anti-aging and anti-inflammatory

Conditions: Skin Condition

Summary: 60 subjects were recruited and divided into placebo group and fermented grape drinks group.

in this study, using a fermented grape drinks made of fermented grapes with fruit and vegetable powder to explore whether it can improve the skin's condition and achieve anti-inflammatory effects. sixty subjects were recruited and divided into placebo group and fermented grape drinks group. after drinking for 8 weeks, skin test and blood biochemical analysis were performed.

Eligibility criteria:
inclusion criteria: 1. dry skin. 2. rough skin 3. large pores 4. dark yellow complexion 5. sagging skin exclusion criteria: 1. skin disorders 2. liver diseases 3. kidney diseases 4. allergy to cosmetics, drugs, or foods 5. pregnant and lactating women 6. people who had any cosmetic procedures before 4 weeks of the study 7. area of facial spot over 3 cm2 8. vegan 9. people who took collagen supplements in the past 3 months.
simplified rapid hydration in preventing ca-aki among patients with chronic kidney disease

Conditions: Chronic Kidney Disease

Summary: no well-defined protocols exist to guide fluid administration for prevention of contrast-associated acute kidney injury in high risk patients. the investigators will compare long term hydration at routine speed(12h before and after procedure at 1ml/kg/h) with short term hydration at high speed(1h before and 4h after procedure at 3ml/kg/h) to verify our hypothesis that the short term hydration may not be inferior to the long one.

no well-defined protocols exist to guide fluid administration for prevention of contrast-associated acute kidney injury in high risk patients undergoing coronary angiography. long term hydration at routine speed(12h before and after procedure at 1ml/kg/h), as the most recommended adequate hydration, has been carried out to prevent contrast-associated acute kidney injury in lots of clinical trials. base on the data in the poseidon randomized controlled trial with hemodynamic-guided fluid administration, short term hydration at high speed(1h before and 4h after procedure at 3ml/kg/h) may not be inferior to the classic long term hydration, the speed should be reduced half of the intended speed in all the patients. we hypothesized short term hydration may not be inferior to the long one to reduced significantly the hospital stay and healthy cost.

Eligibility criteria:
inclusion criteria: * ≥18 years of age; * written informed consent; * candidates scheduled for coronary intervention (angiography and/or coronary intervention); * patients with chronic renal insufficiency, the baseline estimated glomerular filtration rate (egfr) was 15-60 ml/min / 1.73 m² * at least one risk factor (age\>75 years, medical history of diabetes mellitus or hypertension, congestive heart failure \[nyha class \>ii or history of acute pulmonary edema\]); exclusion criteria: * end-stage renal failure or heart/renal transplantation; * history of exposure to contrast medium or acute infectious diseases within 48 hours prior to the procedure; * acute decompensated heart failure; * left ventricular thrombus; * allergy to contrast agent; * pregnancy or lactation; * malignant tumour or life expectancy \<1 year; * pre-procedural receipt of nsaids (except asprin), aminoglycosides, cyclosporine or cisplatin in the past 48 h; * severe valve disease or elective undergoing surgery.

Keywords: contrast-associated acute kidney injury coronary angiography chronic kidney disease intravenous hydration