Kornimate/medical-research-clean huggingface dataset:
nutritional assessment of children with chronic kidney disease

Conditions: Nutrition Disorders, Child

Summary: primary outcome is assessment of nutritional status of children with ckd. secondary outcome is assessment stamp screening tool for detection of malnutrition of ckd children.

pediatric chronic kidney disease (ckd) has systemic implication on all aspects of normal development, including nutrition, growth, bone and mineral metabolism and neurocognitive function . chronic kidney disease (ckd) introduces a unique set of nutritional challenges for the growing and developing child .

Eligibility criteria:
inclusion criteria: * children of both sexes. * diagnosed as chronic kidney disease. * age: 2 years up to 15 years children. exclusion criteria: * • age: less than 2 years old child and more than 15 years old child. * previously diagnosed to have any co- morbid or systemic disease other than ckd. * irregular dialysis. * renal transplant.

Keywords: chronic kidney disease
clinical research protocol of ferumoxytol for magnetic resonance enhancement imaging in patients with atherosclerosis.

Conditions: Atherosclerosis

Summary: we are preparing to initiate a clinical trial involving ferumoxytol for magnetic resonance-enhanced imaging in patients with atherosclerosis. the aim of this study is to assess the safety and effectiveness of ferumoxytol for magnetic resonance angiography in patients with atherosclerosis.

in this study, the safety of ferumoxytol as an mr imaging contrast agent will be assessed by monitoring vital signs and laboratory parameters such as complete blood count, urinalysis, and liver and kidney function tests before and after administration of ferumoxytol. following the injection, all patients will undergo two mri scans at different time intervals, ranging from 0 to 15 hours and from 24 to 48 hours. within one week prior to the injection, patients will undergo standard laboratory tests as part of their routine clinical assessment, and the pre-administration lab results will be documented. this study will prospectively enroll patients with atherosclerosis, and ferumoxytol-enhanced mra imaging will be performed on all patients to investigate the diagnostic utility of ferumoxytol as an mr imaging contrast agent.

Eligibility criteria:
inclusion criteria: patients aged 18 years and older with atherosclerosis. exclusion criteria: individuals with a history of allergy or hypersensitivity to iron or dextran. patients currently receiving oral or intravenous iron therapy. patients with hemosiderosis or hemochromatosis. patients with a history of allergic reactions to intravenous iron products or any iron overload-related conditions. individuals who are unable to undergo magnetic resonance imaging (mri) due to psychological reasons (such as claustrophobia) or physical reasons (such as the presence of non-compatible metallic objects in the body). patients with end-stage diseases or life expectancy less than 1 year. pregnant women. any other individuals deemed unsuitable for inclusion by the investigator.
korean post-marketing surveillance for reyataz®

Conditions: HIV-1

Summary: the purpose of this post-marketing surveillance is to investigate and confirm the type and incidence of newly identified adverse events and any other factors affecting safety and efficacy of reyataz® so that the regulatory authority can manage the marketing approval properly


Eligibility criteria:
inclusion criteria: * patients ≥ 13 years of age with hiv-1 who are on reyataz® treatment at the time of enrollment and have never been participated in this study previously or who are initiating reyataz® treatment for the first time in the real-life conditions in its registered indication(s) as required by kfda exclusion criteria: * according to warning/caution in local label
stress reduction and hypertension prevention in african americans

Conditions: High Blood Pressure

Summary: there are major health disparities in blacks associated with high blood pressure (bp) and psychosocial stress. we evaluated the effects of lifestyle modification with meditation in black adults with high normal and normal blood pressure. participants (n=304) were randomized to either the transcendental meditation technique or health education control in addition to usual care for up to 36 months for bp and secondary outcomes.

background: blacks suffer from disparities in hypertension, cardiovascular disease (cvd) and currently, coronavirus-19. these conditions are associated with social determinants of health and psychosocial stress. while previous trials demonstrated stress reduction lowering blood pressure in grade i range in blacks, there is a paucity of clinical trial data in blacks with high normal and normal bp. objective: this randomized controlled trial was conducted to evaluate the effect of stress reduction with the transcendental meditation (tm) technique in black adults with high normal bp and normal bp using international society of hypertension (ish) definitions. methods: a total of 304 black adults with high normal (130-139/85-89 mm hg) and normal bp (120-129/80-84 mm hg) were randomized to either tm or health education (he) arms. bp was recorded at 3, 6, 9, 12, 24, 30, and 36 months after baseline. linear mixed model analysis was conducted to compare the bp change between tm and he participants in the high-normal bp and normal-bp groups. survival analysis for hypertensive events was conducted.

Eligibility criteria:
inclusion criteria: * self-identified black women and men * no current antihypertensive medications * high normal bp (130-139 mm hg and/or dbp 85-89 mm hg) or * normal bp (sbp 120-129 mm hg and/dbp 80-84 mm hg) exclusion criteria: * use of antihypertensive medications within the previous 2 months * history of cvd, ie, myocardial infarction, angina, peripheral artery disease, heart failure, stroke, or renal failure, diabetes, major psychiatric or substance use disorder other life-threatening illness * lack of signed a consent form

Keywords: blood pressure stress reduction meditation lifestyle modification
the life paths that lead teenagers to attempted suicide:trajectories of proximal adversity

Conditions: Suicide, Attempted

Summary: suicidal behaviors seriously alter the vital and functional prognosis of adolescents. although the literature has lighted out a considerable number of risk factors for suicide attempts in youth, theoretical models - among which bio-psycho-social models - still lack empirical evidence. more specifically, the way adverse life events dynamically interact together and with the individual's diathesis to precipitate suicidal attempts remains unclear. studies of life trajectories have opened an alternative approach to traditional linear epidemiological analysis to capture such a complex process. to date, adverse trajectories approaches never have been applied to the period immediately preceding the occurrence of the suicidal gesture (proximal adverse trajectories).


Eligibility criteria:
inclusion criteria: * inclusion criteria for cases * youth aged 15-24 inclusive * who stayed at the hospital or in the emergency room for less than 15 days after a first suicide attempt * who were discharged less than 15 days ago * who gave their informed consent for majors, or whose parents gave their informed consent for minors inclusion criteria for controls * youth aged 15-24 inclusive * who have never experienced any suicidal ideation or suicide attempt * who gave their informed consent for majors, or whose parents gave their informed consent for minors inclusion criteria for informants * close relatives of the participant * who are major * who lived in the same household as the participant or have interacted with him/her for more than half the weeks of the year preceding the index suicide attempt exclusion criteria: * no consent or consent withdrawal for majors and/or their parents for minors * neurological or psychiatric condition altering the capacity to understand

Keywords: suicide attempt adolescence adverse life event developmental model trajectories
estrogen and graft atherosclerosis research trial (eager)

Conditions: Cardiovascular Diseases; Coronary Arteriosclerosis; Coronary Disease; Heart Diseases; Myocardial Ischemia; Postmenopause

Summary: to determine if postmenopausal hormone replacement therapy in women following coronary bypass surgery would reduce the occurrence of graft occlusion and delay the development of graft atherosclerosis.

background: coronary atherosclerosis is a major cause of death in women in the united states. although coronary artery bypass surgery decreases symptomatic and clinical evidence of ischemia, it does not alter the underlying process. patients may present several years later with recurrent symptoms that may be a result of occlusion of saphenous vein grafts, development of atherosclerotic disease in vein grafts, or progression of underlying disease. any intervention that can reduce the rate of progression of coronary atherosclerosis following bypass surgery would provide significant benefit for women following bypass surgery and possibly for other women with atherosclerotic disease. observational studies suggest that postmenopausal estrogen replacement therapy is associated with a reduction in cardiac morbidity. design narrative: the study was a randomized, double-blind, controlled trial. subjects were randomized to conjugated estrogen with daily medroxyprogesterone or placebo within two weeks of bypass surgery. graft occlusion and development of vein graft atherosclerosis were measured by comparing quantitative coronary angiographic and vascular ultrasonic assessment of disease severity and extent performed at six months and three and a half years after randomization. the primary outcome variables included the occurrence of graft occlusion at six months and the change in severity and extent of atherosclerosis in the saphenous vein grafts over three years. the trial determined the influence of hormone replacement therapy on the primary outcome variables. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
postmenopausal women who had undergone coronary artery bypass graft.
a clinical trial to study the effect of a drug, curcumin in patients with periodontitis

Conditions: Periodontitis

Summary: the study will follow a parallel arm, randomised, double blinded, placebo controlled design. there will be two groups group 1 = receiving 1% curcumin chips after routine scaling and root planing (n=20) group 2 = receiving placebo chips after routine scaling and root planing (n=20) clinical parameters: ( baseline, 4 weeks, 12 weeks) probing pocket depth, clinical attachment level, gingival index, plaque index cytokine parameter ( baseline, 4 weeks) interleukin 1 beta in gcf statistical analysis repeated measures of anova paired t-tests


Eligibility criteria:
inclusion criteria: 1. systemically healthy individuals 2. presence of a minimum of 20 teeth in the oral cavity 3. localised periodontal pockets with probing depths greater than 4mm i.e., periodontitis in its stages 2 and 3, as described by the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions, and published by the american academy of periodontology (aap) exclusion criteria: 1. known allergy to curcumin and/ or hydroxyl propyl methyl cellulose 2. systemic diseases and/or inflammatory conditions, obesity 3. former or current tobacco users 4. chronic consumption of alcohol 5. use of anti-inflammatory drugs and antibiotics over the past 3 months 6. periodontal therapy in any form, surgical or non surgical in the past 6 months 7. pregnant and lactating mothers

Keywords: periodontitis, 1% curcumin chips, host modulation therapy, anti inflammatory effect, interleukin 1 beta
pancrelipase with nutritional supplement in patients at risk of malnutrition (effort-enzo)

Conditions: Malnutrition

Summary: this study investigates if pancreatic enzymes in combination with oral nutritional supplement can improve nutrient bioavailability in older people with malnutrition or at risk of malnutrition.

this study investigates whether adding digestive pancreatic enzymes to oral nutritional supplements (ons) can improve nutrient absorption in older adults at risk of malnutrition. while ons are commonly recommended, their effectiveness is often limited due to age-related declines in exocrine pancreatic function, leading to reduced enzyme secretion. studies indicate that pancreatic lipase levels decline with age, potentially impairing nutrient digestion and absorption. the study proposes using pancrelipase (zenpep®), an fda-approved pancreatic enzyme replacement therapy, to enhance nutrient bioavailability. the randomized, placebo-controlled trial will assess whether pancrelipase improves postprandial levels of amino acids, fatty acids, and glucose in hospitalized patients at nutritional risk. the study aims to determine if pancreatic enzyme supplementation can enhance nutrient absorption and provide a novel strategy for managing malnutrition in older adults without diagnosed exocrine pancreatic insufficiency (epi). if successful, this approach could improve clinical outcomes, reduce healthcare costs, and enhance quality of life.

Eligibility criteria:
inclusion criteria: * informed consent as documented by signature * male or female 70 years of age or older * hospitalized at site * nutrition risk screening 2002 (nrs-2002) ≥ 3 * egfr ≥ 30 ml/min/1.73 m2 (epi-ckd) based on medical history (no older than 6 months) * ability to eat orally exclusion criteria: * patients with acute cardiovascular event ≤ 2 days * patients with terminal conditions * patients diagnosed with pancreatic exocrine insufficiency (epi) treated with pancreatic enzyme replacement therapy (pert) * patients having a planned transplant or new-onset dialysis in the next 6 months. * patients having a colectomy, resection of the small intestine or cholecystectomy * known hypersensitivity to any of the substances or excipients of the ons or the medicinal product

Keywords: pancrelipase oral nutritional supplements
project affinity: excess cancer blood testing

Conditions: Cancer

Summary: study investigating cancer blood samples on an iterative measurement systme


Eligibility criteria:
inclusion criteria: * undergoing sact * routine blood tests exclusion criteria: * not had first cycle of sact
registry of cutting balloon and dcb intervention in femoropopliteal stenosis/occlusion.

Conditions: Peripheral Artery Disease; Femoropoliteal Stenosis/Occlusion; Cutting-balloon; Drug-coated-balloon

Summary: observational registry including patients with peripheral artery disease due to femoro-popliteal stenosis or occlusion treated with cutting ballon- and subsequent drug-coated-ballon-percutaneous-transluminal-angioplasty (pta).

the registry includes consecutive patients with symptomatic peripheral artery disease due to femoro-popliteal stenosis or occlusion treated with cutting ballon- and subsequent drug-coated-ballon-percutaneous-transluminal-angioplasty (pta). interventional procedure: 1. pta with cutting-balloon (60-120 seconds). 2. pta with drug-coated-balloon (60 seconds). technical success is defined as 1. no recoil \>30% 2. no dissection \>type b 3. no stenting \>30% of lesion length. follow-up of patients after 6 months and 12 months (abi, rutherford-classification, mace, tlr, tvr, binary restenosis).

Eligibility criteria:
inclusion criteria: * peripheral artery disease (pad) with femoro-popliteal stenosis \>70% or occlusion (vessel diameter 4-6mm) * age 18-99 * informed consent exclusion criteria: * proximal / iliacal stenosis * stenosis/occlusion of all arteries below the knee

Keywords: pad femoropoliteal stenosis/occlusion cutting-balloon drug-coated-balloon
examination of pain in individuals with non-specific lack pain

Conditions: Back Pain; Balance; Proprioception

Summary: the aim of this study is to examine the relationship between pain, and balance, proprioception sensation in the knee, erector spinae and multifidus muscle strength in individuals with non-specific low back pain.

impaired postural control in people with non-specific low back pain; it can be affected by many factors such as pain, musculoskeletal disorders, proprioception. postural control is important for the continuation of activities of daily living. postural control is decreased in patients with non-specific low back pain. according to the proprioception examinations, patients with low back pain are more impaired than healthy individuals. impaired proprioception can also reduce the ability to maintain posture, balance control and increase the load on the spine. thus, individuals with low back pain may become more vulnerable to injuries. weakness of the abdominal muscles and superficial trunk muscles are also risk factors for low back pain. weakness and fatigue may occur as a result of structural changes, which are more common in the paraspinal muscles and the multifidus muscle. this can lead to deterioration of lumbar stability. because these muscles have an important place in providing stability. proprioceptive information from the hip, knee and ankle and coordination of the joints are important in maintaining and controlling balance. regional receptors in muscles, joints, skin and tendons and proprioception in the knee joint provide the necessary joint activity and stabilization. with the decrease in balance and proprioception, pain may occur, and we may encounter a decrease in muscle strength as a result of leading a sedentary life. in this case, since the proper posture, muscle activity and balance required for coordinated movement are negatively affected, the movement is impaired. because these activities must be performed in the correct order for the movement to occur. in the literature, there are studies on the relationship of low back pain with muscle strength, balance and proprioception; however, the lack of sufficient studies investigating the relationship between balance and proprioception in the knee in individuals with non-specific low back pain suggests that the study to be conducted will make an important contribution to the literature and reveals the importance of our study.

Eligibility criteria:
inclusion criteria: * having pain intensity of 3 or more according to vas. * having a mini mental test score of 24 and above * being able to stand on one leg. * having low back pain for 3 months or more exclusion criteria: * osteoporosis * being in the 0%-20% range on the oswestry scale * pregnancy * being on constant painkillers for one reason or another * having undergone lumbar, hip, knee and ankle surgery. * having severe hearing, vision, speech impairment

Keywords: low back pain balance proprioception
indocyanine green lymphography in management of lingual lymphatic malformation

Conditions: Lymphatic Malformation

Summary: to elucidate the application of indocyanine green (icg) fluorescence angiography in the treatment of childhood tongue clm (clinically localized malignancy, presumed context here), providing a clearer scientific basis for subsequent targeted interventions.


Eligibility criteria:
inclusion criteria: * no previous intervention * more than 6 months post-treatment follow-up * stage i or stage iia exclusion criteria: * history of iodine allergy * syndromic clm * severe liver and kidney dysfunction

Keywords: indocyanine green tongue lymphatic malformation
position and predictive factors of hypotension in prone percutaneous nephrolithotomy

Conditions: Hypotension; Urolithiasis

Summary: this study was designed to investigate the effect of position and predictive factors on hypotension in patients performing percutaneous nephrolithotomy. patients aged \>18 years and asa i-iii who underwent general or regional anaesthesia were included in the study. percutaneous access was performed in all patients with fluoroscopy in the prone position.

this study was designed to investigate the effect of position and predictive factors on hypotension in patients performing percutaneous nephrolithotomy. patients aged \>18 years and asa i-iii who underwent general or regional anaesthesia were included in the study. percutaneous access was performed in all patients with fluoroscopy in the prone position. age, gender, body mass index(bmi), smoking, type of anaesthesia, duration of anaesthesia and surgery were recorded. the ecg, spo2, and non-invasive blood pressure values were recorded intraoperatively. preoperative and postoperative 12th hour hb,bun, cr,na,k and cl were measured in a blood sample. isotonic was used as an intravenous fluid in all participants. in treatment of hypotension routine ephedrine treatments were recorded. in the literature, studies in pcnl surgery have focused on data such as method, duration of bleeding and fluoroscopy, electrolyte-metabolic changes, and complications such as fever, hypothermia, pleural damage, and hospital stay. a limited number of studies have focused on bleeding and hemodynamics in comparing surgical methods in the prone and supine positions. the investigators could not find any study comparing systemic disease effects on intraoperative hypotension (hemodynamic parameters) in prone pcnl surgery.

Eligibility criteria:
inclusion criteria: * patients aged \>18 years and asa i -iii who underwent general or regional anaesthesia were included in the study. exclusion criteria: * patients who received preoperative vasopressor, inotropic infusion, erythrocyte and fresh frozen plasma (ffp), anaemia, uncontrolled coagulopathies, pregnancy, immunodeficiency, asa class iv and emergency surgeries.

Keywords: hypotension prone position nephrolithotomy
effects of esketamine on the incidence of postoperative delirium and postoperative sleep disturbance in elderly patients after major non-cardiac surgery

Conditions: Postoperative Delirium (POD); Postoperative Sleep Disturbance

Summary: postoperative delirium (pod) is a common surgical complication.it is associated with a range of negative outcomes such as delayed postoperative recovery,prolonged hospitalization,additional medical expenditures and higher mortality. meanwhile,sleep disorders are not only an important predisposing factor for delirium,but also one of the main symptoms of delirium.systemic inflammatory responses caused by sleep disorders may be an important mechanism for pod. many studies have shown that esketamie may inhibit inflammatory factors and enhance neuroplasticity. in summary,we felt the need to further explore the therapeutic potential of esketamine in the area of pod as well as postoperative sleep disorders.


Eligibility criteria:
inclusion criteria: 1. age ≧ 65 years; 2. asa ⅰ-ⅲ; 3. elective major non-cardiac surgery; 4. voluntary signed informed consent. exclusion criteria: 1. people with mental illness; 2. suffering from serious central nervous system disorders such as arkinson's disease, alzheimer's disease, etc; 3. elevated intracranial pressure; 4. emergency or trauma surgery; 5. prior history of postoperative delirium or postoperative cognitive decline; 6. the patient has impaired hearing or impaired vision; 7. suffering from severe systemic underlying diseases (e.g. cardiac insufficiency, malignant arrhythmia, malignant hypertension, hepatic failure, renal failure, etc.); 8. the patient is in chronic pain; 9. the patient is severely malnourished; 10. patients with stage 3 or 4 malignant tumors, pancreatic cancer, allbladder cancer, cholangiocarcinoma and other tumors with high malignancy and poor prognosis. 11. history of allergy to or contraindication to esketamine; 12. inability or unwillingness to complete questionnaires or clinical testing; 13. unable or unwilling to use a postoperative intravenous analgesic pump.

Keywords: esketamine non-cardiac surgery postoperative delirium (pod) postoperative sleep disturbance