Kornimate/medical-research-clean huggingface dataset:
progesterone levels and endometrial compaction in frozen-thawed embryo transfer cycles

Conditions: Infertility, Female; Infertility of Uterine Origin; Implantation; Placenta

Summary: this study is intended to determine whether there is a correlation between endometrial compaction and serum progesterone levels on the day of frozen embryo transfers by using transvaginal sonography for the endometrial assessment.

this study is planned to be conducted by prospectively evaluating approximately 200 frozen embryo transfers within 6 months in a single center. patients planned to be included in the study are started estrodiol 6 mg / day on day2-3 of mensturation. 12 days after the start of estrogen, patients who have endometrial thickness over 7 mm are then started vaginal progesterone supplementation as per routine practice and are eventually proceeded to embryo transfer either on day 4 or 6 of progesterone supplementation. in this study investigators are intended to measure endometrial thickness transvaginally on the day of embryo transfer to accurately determine the presence of endometrial compaction, assess serum progesterone levels, evaluate any possible correlations between endometrial compaction, serum progesterone levels and pregnancy rates.

Eligibility criteria:
inclusion criteria: 1. woman aged 20-40 years 2. hormonal(estrogen and progesterone) frozen- thawed embryo transfer cycles 3. having available blastocyst(s) cryopreserved by vitrification method. exclusion criteria: 1. recurrent implantation failure 2. recurrent pregnancy loss 3. presence of uterine pathology 4. requirement for fresh embryo(s); 5. presence of any clinically relevant systemic disease contraindicated for assisted reproduction or pregnancy 6. allergy history for relevant drugs 7. body mass index of \ 38 kg/m2 at screening 8. current breastfeeding or pregnancy 9. refusal or inability to comply with the requirements of the protocol for any reason, including scheduled clinic visits and laboratory tests 10. natural or modified natural cycles

Keywords: frozen-thawed embryo transfer endometrial compaction progesterone
better sleep in psychiatric care - depression, anxiety and ptsd

Conditions: Sleep Problem; Anxiety Disorders; Affective Disorder

Summary: cognitive behavioral therapy (cbt) is treatment of choice for insomnia. many patients in psychiatric care have sleep problems including insomnia, but are rarely given the choice to participate in cbt to improve their sleep. patients with ptsd, anxiety disorders and depression display high levels of sleep difficulties. sleep problems are often general, such as insomnia and sleep phase problems. in a previous pilot study, the investigators of the current study developed a cbt protocol that would target sleep problems in this mixed psychiatric population. the basis was cbt for insomnia (cbt-i), but also including techniques that would alleviate sleep phase problems (e.g. the systematic use of light and darkness), and techniques to target more general sleep related problems (e.g. difficulties waking up in the morning), that are also common in psychiatric patients. this treatment was well tolerated and gave large withing-group effects on insomnia severity in the pilot study. in a naturalistic randomized controlled trial, the investigators now evaluate the effects of this psychological treatment on sleep and anxiety and depressive symptoms in patients at the units for anxiety and affective disorders and trauma, southwest psychiatry and northern stockholm psychiatry, stockholm county council, sweden.


Eligibility criteria:
inclusion criteria: * being a patient at the clinics involved in the project * experiencing sleep problems (subjective report) * being able to participate in a psychological intervention in group format exclusion criteria: * night shift work

Keywords: cognitive behaviour therapy psychological intervention
an observational study to evaluate the effectiveness of mircera treatment for renal anemia in pre-dialysis participants with chronic kideny disease (ckd)

Conditions: Kidney Disease, Chronic

Summary: this observational trial will examine the efficacy and safety of mircera for renal anemia in participants with stage iii-iv ckd in daily clinical practice. mircera will be prescribed by treating physician and followed for approximately 36 months.


Eligibility criteria:
inclusion criteria: * participants aged \> 18 years with ckd * participants who are eligible for mircera treatment according to current guidelines and summary of product characteristics (smpc) exclusion criteria: * non-renal anemia * pregnancy and breast-feeding * uncontrolled hypertension * known hypersensitivity to methoxy polyethylene glycol-epoetin beta * administration of any other study drug within 30 days prior to study enrollment
thoracic epidural versus general anesthesia for laparoscopic cholecystectomy

Conditions: Epidural Anesthesia; General Anesthesia

Summary: eighty two patients planned to undergo elective laparoscopic cholecystectomy were divided into two groups, t and g, randomly. in group t all patients underwent laparoscopic cholecystectomy under thoracic epidural anesthesia with 12mlof 0.25% bupivacaine and 1% lignocaine plain whereas in group g all patients underwent surgery under general anesthesia. intra-operative heart rate, mean arterial pressure (map) and post operative opioid consumption in first 24hrs were recorded as primary outcomes whereas presence or absence of respiratory complication and duration of hospital stay as secondary outcome.


Eligibility criteria:
inclusion criteria: 1. patients having asa statusi-iii 2. age more than 18 years, 3. both genders 4. planned to undergo laparoscopic cholecystectomy exclusion criteria: 1. patients who did not give consent, 2. allergic to local anesthetic 3. hemodynamically unstable, 4. pregnant, full stomach patients

Keywords: headache blood pressure
hospitalization or ambulatory treatment of acute diverticulitis

Conditions: Diverticulitis

Summary: the purpose of 01diver is to evaluate efficacy and safety of a home treatment protocol for non complicated diverticulitis compared with management in the hospital. the hypothesis is that a ambulatory treatment with oral antibiotic and progressive introduction of diet is not inferior to the conservative management in hospital in patients with acute not complicated sigmoid diverticulitis, shown by contrast enhanced ct scan. patients are prospectively randomized to conservative antibiotic treatment either to ambulatory or to hospital treatment.


Eligibility criteria:
inclusion criteria: * age older than 18 years * diagnosis of mild diverticulitis by abdominal computerized tomography * signed informed consent exclusion criteria: * severe diverticulitis * informed consent not signed * suspicion of colon cancer * pneumoperitoneum * intolerance for oral feeding * antibiotics for diverticulitis in the last month * immunosuppression * pregnancy or lactation * severe (decompensated) other illness * psychological or social problems

Keywords: diverticulitis not complicated diverticulitis
investigation of the relationship between body image perception, proprioception, cobb angle and posture in individuals with adolescent idiopathic scoliosis

Conditions: Scoliosis; Adolescence; Scoliosis Idiopathic

Summary: scoliosis is a three-dimensional torsional deformation of the spine and trunk. chest deformity and pelvic asymmetry are often seen together with spinal deformity. adolescent idiopathic scoliosis occurs from the onset of puberty until growth plate closure and is the most common of all scoliosis. one of the most common deformities among posture disorders is known as scoliosis. the change in load distribution resulting from this three-dimensional deformation causes postural changes in patients with idiopathic scoliosis. according to a study, it is thought that postural control and central information processing efficiency may decrease as the cobb angle increases in people with scoliosis.

scoliosis, shoulder asymmetry, midline asymmetry, trunk shift and lower extremity length inequality. therefore, it affects body image perception negatively by limiting physical functions and mobility. in a study conducted with individuals with ais, it was found that as the cobb angle increased, body image was adversely affected. it is also known that during the vertebral growth period in idiopathic scoliosis, postural reflex mechanisms originating from the proprioceptive organs and balance problems are associated with the displacement of the vertebrae. as a result of a study on vestibular effect and proprioception, it is concluded that it would be beneficial to include proprioception, balance and coordination exercises in the treatment of scoliosis. in the current literature review, no study was found that investigated the relationships between cobb angle, proprioception, body image perception and posture variables in individuals with adolescent idiopathic scoliosis. the aim of our study is to explain the relationship between some problems accompanied by scoliosis in individuals diagnosed with idiopathic scoliosis. with the results that can be obtained from our study, we aim to explain how posture, proprioception and body image perception are affected in individuals with ais and to contribute to the exercise programs that can be given to the person in line with these results.

Eligibility criteria:
inclusion criteria: * having been diagnosed with adolescent idiopathic scoliosis by a doctor, * not having cognitive, mental and psychological problems, * continuing exercise or brace therapy. exclusion criteria: * having a history of spinal surgery * having a type of scoliosis other than idiopathic, * presence of musculoskeletal system pathologies, * vestibular system disorders.
postural analysis during dental surgery

Conditions: Postural Low Back Pain

Summary: background: attention and awareness towards msds in the dental profession has increased considerably in recent years. from recent literature reviews, it is learned that prevalence of msds in dentists is 64-93%. it has been seen that the use of magnification systems not only improves the operator's visual capabilities, but also allows for a more correct posture, and to prevent the onset of back and neck disorders. purpose and methods: evaluate dentist posture during extraction of third lower molars depending on whether the operator uses the naked eye, surgical loupes or surgical microscope systems. data will be evaluated through the index rula (rapid upper limb assesment) to define whether there is a change in exposure to the risk of msds (muskoloskeletal disease) and using fiducial markers for the movement analysis of the operator during the procedure.

study design: randomized controlled clinical trial. purpose: evaluate dentist posture during extraction of third lower molars depending on whether the operator uses the naked eye, surgical loupes or surgical microscope systems. methods: data will be analysed through the index rula (rapid upper limb assesment) to define whether there is a change in exposure to the risk of msds (muskoloskeletal disease). posture assessment will be based on 3-d data of the upper body, which can discriminate spatial displacements up to 2mm in translation and 1 degree in rotation. the surgical intervention will be performed under local anesthesia (mepivacaine 20 mg/ml with adrenaline 1:100000) and by the use of microscope (opmi movena s7) or surgical loupes or no magnifying system. during this session the following data will be collected for the study: 1. demographic data (baseline) 2. medical and dental history 3. parameters related to the lower third molar 4. radiographic tests 5. marker operator position 6. pre- and postoperative photographs each patients will be recalled for follow-up visits at 7 days. during this session will be carried out the removal of stitches and data will be recorded as follows: 1. vas pain and trismus. 2. number of painkillers taken 3. control photographs 4. posse scala

Eligibility criteria:
inclusion criteria: * patients elements 38 or 48 in dysodontiasis requiring a complex extraction * able to sign informed consent exclusion criteria: * general contraindication to surgical treatment * pregnancy * lactation * age under 18 years
impact of whole-body vibration training on sarcopenic elderly

Conditions: Sarcopenia

Summary: sarcopenia is defined as a phenomenon which the amount of muscle mass in elderly aged 60-70 years is about 20-30% lower than that of the young adults and middle-aged people due to muscle atrophy caused by aging and alteration in muscle itself in aged skeletal muscle. whole body vibration(wbv) training can be a choice for hospitalized patients who cannot conduct high intensity resistance training.

this study is prospective study. the goal of this study is 1. to investigate the effect of whole body vibration training using vibration platform with tilt table on muscle mass, muscle strength, physical performance in hospitalized older adults with sarcopenia. 2. to demonstrate whether whole body vibration training using vibration platform with tilt table can be useful in hospitalized older adults with sarcopenia who could not perform high intensity exercise.

Eligibility criteria:
inclusion criteria: * more than 70-year old people who admitted seoul national university hospital, bundang. * deconditioning subjects with diabetics, infections, chronic lung disease, etc. who cannot walk independently due to long-term hospital care. * subjects who had a mobility impairment. * subjects who can agree voluntarily. exclusion criteria: * subjects who inserted implant due to trauma within 1\~2 months recently. * acute coronary syndrome. * uncontrolled hypertension. * subjects who took drugs which can affects neuromuscular system. * severely impaired cognition * subjects who cannot agree volun.tarily.

Keywords: sarcopenia vibration gait muscle rehabilitation
semantic and syntactic computerized analysis of free speech

Conditions: Psychotic Disorders; Psychosis; Schizophrenia and Related Disorders; Schizophrenia Prodromal; Diagnosis, Psychiatric

Summary: subtle speech disorganization could be predictive of a transition to schizophrenia of ultra-high-risk patients. the aim of our longitudinal multicenter cohort study is to identify specific linguistic markers of the psychotic transition to validate a french predictive model of this transition using computerized speech analysis techniques

different scales allow identification of patients at ultra-high-risk to develop psychosis. the current challenge is to identify a predictive marker of transition to schizophrenia. language disorders, which reflect psyche, could be one of these markers. computerized speech analysis techniques such as latent semantic analysis (lsa) have already proven their reliability in schizophrenia. these techniques reveal subtle speech disorganization that would be predictive of a clinical transition of ultra-high-risk psychotic patients. a combination of semantic and syntactic analysis could accurately predict the psychotic transition. the aim of our longitudinal multicenter cohort study is to validate this predicitve model in french language as well as identifying specific linguistic markers of the psychotic transition. the initial report including the caarms is completed with an audio recording from the initial medical interview. the recording will be transcribed and analyzed by computer following the method of lemmatization and vectorial analysis (lsa). an analysis of the grammatical function (number of words, rate of the various grammatical functions) will also be performed. this first analysis will emerge linguistic markers correlated to transition to psychosis that we will use to construct a predictive model for transition to schizophrenia.

Eligibility criteria:
inclusion criteria: * major and/or minor from 15 to 30 years old * who alleged a suicidal gesture or idea or behavior that has repercussions in their emotional, social or professional life * if patients receive neuroleptic treatment that impairs cognitive abilities, a one-week wash-out period will be scheduled prior to assessment. exclusion criteria: * history of psychosis * risk of self-harm or violence not compatible with outpatient treatment * qi\<70 (wais) * neurological disorder or major health problem * impossibility to interrupt neuroleptic treatment for one week * refusal to participate

Keywords: psychotic disorders diagnosis, psychiatric schizophrenia prodromal ultra high risk prediction of psychosis machine learning automated language analysis semantic coherence syntaxic complexity
study in epcam positive patients with symptomatic malignant ascites using removab versus an untreated control group

Conditions: EpCam Positive Tumor (e.g.Ovarian, Gastric, Colon, Breast); Malignant Ascites

Summary: the study will be performed to obtain further efficacy and safety data in order to obtain a marketing authorization (pivotal study). in addition, health economic data are to be collected.


Eligibility criteria:
inclusion criteria: * histological confirmed diagnosis cancer * symptomatic malignant ascites * epcam positive tumor * eocg 0-2 * negative pregnancy exclusion criteria: * acute or chronic infection * exposure to investigational product, cancer chemo- or radiotherapy within the last 28 days * previous treatment with mouse monoclonal antibodies * known or suspected hypersensitivity to removab or similar antibodies * inadequate renal function * inadequate hepatic function (ast, alt, gtp,\< x uln; bilirubin \<1.5xuln) * platelets \> 80000 cells/mm3; absolute neutrophil count (anc) \< 1500 cells/mm3 * bmi \< 17 * patients with reduced nutritional status * ileus within the last 30 days * brain metastases in cancer history * pregnant and nursing women * history of myocardial infarction, congestive heart failure or relevant cardiac arrhythmia within previous 3 months * inadequate respiratory function in option of investigator

Keywords: epcam positive tumor malignant ascites intraperitoneal
a study of setrobuvir in combination with pegasys (peginterferon alfa-2a) and copegus (ribavirin) in patients with genotype 1 chronic hepatitis c

Conditions: Hepatitis C, Chronic

Summary: this randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of setrobuvir in patients with genotype 1 chronic hepatitis c. treatment-naïve patients will be randomized to receive either setrobuvir (800 mg orally b.i.d loading dose followed by 200 mg orally .b.i.d.) or placebo in combination with standard of care pegasys (peginterferon alfa-2a) and copegus (ribavirin). treatment duration will be 28 weeks or 48 weeks depending on response. treatment-experienced patients categorized as relapsers, partial responders and viral breakthrough patients to previous pegylated interferon and ribavirin therapy will be randomized to receive either setrobuvir or placebo in combination with pegasys and copegus for 48 weeks. treatment-experienced patients categorized as null-responders to previous pegylated interferon and ribavirin therapy will be assigned to treatment with setrobuvir plus pegasys and copegus for 48 weeks.


Eligibility criteria:
inclusion criteria: * adult patients, 18 to 65 years of age inclusive * documented chronic hepatitis c * treatment-naïve (no prior exposure to pegasys, copegus, or experimental hcv therapy) or treatment-experienced with current standard of care (pegasys and copegus) but categorized as null-responder or patients with partial response, relapse or viral breakthrough during or following prior treatment * serum hcv rna \>/= 50,000 iu/ml at screening * hcv antibody positive at screening * hcv genotype 1 * body mass index (bmi) 18-38 kg/m2 * in good health other than chronic hcv infection in the judgment of the principal investigators * negative for hepatitis b and hiv infection exclusion criteria: * pregnant or breastfeeding women * for treatment-naïve patients: any previous treatment for hcv infection * for treatment-experienced patients: previous treatment with an experimental therapy for hcv infection * co-infection with hiv or hepatitis c virus (hbv) * history or evidence of decompensated liver disease * history or evidence of hepatocellular carcinoma * history of alcohol abuse and/or other drug addiction \</= 1 year prior to enrollment in the study * poorly controlled diabetes mellitus * one or more additional known primary causes of liver disease other than hepatitis c * history of acute or chronic pancreatitis * participation in an other clinical study of a new chemical entity within 30 days prior to study randomization
racial distribution of heterotaxy syndrome

Conditions: Congenital Disorders

Summary: heterotaxy syndrome is a heterogeneous disease that is the result of a failure of normal right-left lateralization of the abdominal and thoracic organs during development. the major clinical manifestations include intestinal malrotation, functional asplenia and complex cyanotic heart disease. hypothesis: there exists a yet, un-recognized, racial distribution in heterotaxy syndrome.

the exact etiology of heterotaxy is unknown, but presumed to be multifactorial. while candidate genes have been suggested, no common gene has proven responsible for this constellation of lesions. various modes of inheritance have been described. though there are reports of familial occurrences, no reports of racial/ethnic predominance exist. we, therefore, propose to examine the racial/ethnic distribution of heterotaxy syndrome with congenital heart disease in patients treated at this institution. in addition, the investigators will determine if race/ethnicity is a factor in clinical outcomes. aim 1: to determine any pattern of racial/ethnic predominance within a cohort of patients with heterotaxy syndrome with congenital heart disease. aim 2: to correlate race/ethnicity with disparities in morbidity and mortality in patients with heterotaxy syndrome with congenital heart disease. this study will be a retrospective, chart review of approximately 90 - 100 medical charts, conducted on the egleston campus of children's healthcare of atlanta. charts reviewed will cover a period between january 1, 1990 and december 31, 2005. data to be collected includes: dob, diagnosis, surgical procedure, surgical outcome, survival, length of hospitalization, repeat surgical intervention, incidence of hospitalization, length of inotropic support, ventilator time, infection rate, insurance provider, list of antibiotics and zip code of residence at initial admission. in addition to the above information, data to be extracted from the medical chart of a decedent will include age at death, cause of death, laboratory data at time of death and autopsy results.

Eligibility criteria:
inclusion criteria: * all medical charts diagnosed clinically and at autopsy with heterotaxy syndrome, left atrial isomerism, right atrial isomerism or situs inversus totalis with congenital heart disease over a 16 consecutive year period at children's healthcare of atlanta at egleston. exclusion criteria: * those who do not meet inclusion criteria

Keywords: heterotaxy syndrome intestinal malrotation functional asplenia complex cyanotic heart disease