Kornimate/medical-research-clean huggingface dataset:
efficacy testing of collagen elixir

Conditions: Skin Condition

Summary: to assess isagenix-collagen elixir on skin condition improvement


Eligibility criteria:
inclusion criteria: * healthy adults aged above 20 years old exclusion criteria: * subject who is not willing to participate in this study. * patients with diseases of the skin, liver, kidney. * subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. * female who is pregnant or nursing or planning to become pregnant during the course of the study. * received facial laser therapy, chemical peeling or uv overexposure in the past 4 weeks. * constant drug use * participated cosmetic product human study in the past 3 months.
a non-invasive approach to the assessment of volume status in mechanically ventilated septic patients.

Conditions: Severe Sepsis; Septic Shock

Summary: to evaluate the use of sonographic inferior caval vein assessment in mechanically ventilated septic patients. volume assessment in mechanically ventilated patients with inflammation is of major importance to guide fluid therapy. the researchers investigated whether measurement of caval vein diameter correlates with invasively assessed volume-based hemodynamic parameters.


Eligibility criteria:
inclusion criteria: * age 18-90 * presence of severe sepsis and septic shock * invasive hemodynamic monitoring using the picco system

Keywords: presence of severe sepsis and septic shock, mechanical ventilation
multicenter phase 2 trial evaluating cisplatin-gemcitabine with concomitant thoracic radiotherapy for treatment of inoperable stage iii non small cell lung cancer

Conditions: Non Small Cell Lung Cancer

Summary: the purpose of the study is to evaluate the response rate of patients with non small lung cancer to gemcitabine in combination with radiotherapy. the tolerability and safety of this combination will also be evaluated.


Eligibility criteria:
inclusion criteria: * inoperable non small cell lung cancer stage iii * adequate hematological parameters * adequate lung function reserve exclusion criteria: * previous chemotherapy and thoracic radiation for non small cell lung cancer * presence of distant metastases
a twelve week study of supervised mouth rinse and flossing

Conditions: Healthy

Summary: the purpose of this study is to evaluate the efficacy of twice daily alcohol containing essential oil mouth rinse and brushing versus dental flossing and brushing under once daily supervision for the prevention and reduction of plaque and gingivitis.


Eligibility criteria:
inclusion criteria: * able to comprehend and follow the requirements and restrictions of the study (including willingness to use the assigned study products according to instructions, availability on scheduled visit dates and likeliness of completing the clinical study) based upon research site personnel's assessment * able to attend once daily session during weekdays for flossing and rinsing occurring on site * evidence of a personally signed and dated informed consent document indicating the subject (or legally acceptable representative) has been informed of all pertinent aspects of the trial * able to read and understand the local language (participants capable of reading the documents) * adequate oral hygiene (that is brush teeth daily and exhibit no signs or oral neglect) * a minimum of 20 natural teeth with scorable facial and lingual surfaces. teeth that are grossly carious, extensively restored, orthodontically banded, abutments, exhibiting severe generalized cervical and/or enamel abrasion, or third molars will not be included in the tooth count * a minimum of 10 bleeding sites based on the bi * absence of advanced periodontitis based on a clinical examination at baseline and discretion of the dental examiner exclusion criteria: * history of significant adverse effects, including sensitivities or suspected allergies, following use of oral hygiene products such as toothpastes, mouth rinses and red food dye * dental prophylaxis within four weeks prior to screening/baseline visit * history of medical conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures * antibiotic, anti-inflammatory or anticoagulant therapy during the study or within the one month prior to the baseline exam. intermittent use of certain anti-inflammatory medication is acceptable at the discretion of the investigator * use of chemotherapeutic anti-plaque/anti-gingivitis products such as triclosan, essential oils, cetylpyridinium chloride, stannous fluoride or chlorhexidine containing mouth rinses within the two weeks prior to baseline
comparative effect of cylindrical lenses verses spherical equilient on contrast sensitivity

Conditions: Low Vision Aids

Summary: the concept of spherical equivalent plays a pivotal role in simplifying the prescription and enhancing communication between eye care professionals and patients. the spherical equivalent is a calculated value that condenses the spherical and cylindrical components into a single power.

mathematically, it is determined by adding half of the cylindrical power to the spherical power (se = sphere + (cylinder/2)). this calculated value serves as a convenient representation of the overall refractive error, aiding in a more straightforward understanding of the prescription. understanding their individual and collective impact on contrast sensitivity opens up new avenues for refining corrective interventions and enhancing the overall quality of vision. this article aims to demystify the intricate relationship between spherical equivalent and cylindrical correction, and their collective impact on contrast sensitivity.

Eligibility criteria:
inclusion criteria: * patients within 18 to 35 years will be included. * both genders will be included. * patients having astigmatism will be included. * patients having 6/6 corrected vision will be included. * eyes having no other ocular pathology will be included. * patients having no history of ocular surgery or corneal scar will be included. exclusion criteria: * i. eyes having any ocular pathology will be excluded. * patients with corneal suture will be excluded. * those using contact lenses instead of spectacles for vision correction will be excluded. * participants with a history of eye surgery within the past year will be excluded.
a randomized controlled clinical trial on the use of saline nasal irrigations to eradicate localized nasal infection by sars-cov-2

Conditions: Symptoms and Signs

Summary: consecutive adult (\>18 years old) subjects who tested positive for sars-cov-2 with nasopharyngeal swab at the local covid-19 prevention centre were included. patients were divided into two groups: cases (who performed nasal lavages) and controls (who did not perform lavages), with similar confounding factors (age, comorbidities, vaccination status). at the moment of diagnosis, patients were asked to fill out an ad hoc questionnaire to evaluate their symptoms at the moment of diagnosis and of negativization. subjects were asked to perform, at a daily time of their choice, a nasal swab provided at the moment of enrolment. when the subjects tested negative for the first time, they had to complete the questionnaire once again. the study was divided into two phases. in the first phase cases were recruited and were given nasal washes (tonimer panthexyl®) to be performed three times a day, and in any case after nasal swab. in the second phase controls were recruited and were asked to perform only daily nasal swabs. symptoms course and time of negativization were analyzed. statistic comparisons were made using kaplan-meier test. p values \<0,05 were considered to be statistically significant.


Eligibility criteria:
inclusion criteria: * age \>18 years * starting participation to the study within the first 48 hours since diagnosis * ability in self-swabbing * ability in self-administration of nasal lavages exclusion criteria: * age \<18 years * refusal of participation * starting participation to the study after the first 48 hours since diagnosis * no ability in self-swabbing * no ability in self-administration of nasal lavages
hypofractionated vs. conventionally fractionated concurrent crt for ld-sclc

Conditions: Carcinoma, Small Cell; Lung Neoplasms

Summary: the purpose of this study is to determine whether hypofractionated concurrent chemo-radiotherapy has the same efficiency as conventionally fractionated concurrent chemo-radiotherapy in limited disease small cell lung cancer.

for patients with limited disease small cell lung cancer, 45gy/15f of radiotherapy with concurrent chemotherapy will be used in experimental arm. while 60gy/30f of radiotherapy with concurrent chemotherapy will be used in the control arm. both survival and toxicity of the two arms will be observed and compared.

Eligibility criteria:
inclusion criteria: * 18\~70 years old, ecog 0-2 * patients with histologically or cytologically proved small cell lung cancer * limited disease (ld), was characterized by tumors confined to one hemithorax. it may include ipsilateral hilar, both mediastinum and both supraclavicular nodes. metastatic lymph nodes were defined as lymph nodes with short diameter of more than 1cm or fdg uptake in pet. the thickness of pleural effusion was less than 1cm unless malignant pleural effusion was cytologically proved. in a word, stage i-iiib excluding the patients with lung metastases should be defined as ld according to ajcc cancer staging 7th edition. * no progression after 2 cycles of chemotherapy with ep. * no prior history of anti-tumor treatment. * no severe internal diseases and no organ dysfunction * written informed consent provided and exclusion criteria: * malignant tumors of other sites. non melanoma skin cancer and cervical carcinoma in situ were not included if curable. * active heart disease or acute myocardial infarction happen in six months. * psychiatric history. * pregnant woman or woman need to breast feed or woman with positive chorionic gonadotrophin (hcg) * uncontrolled diabetes or hypertension * interstitial pneumonia or active pulmonary fibrosis * acute bacterial or fungal infection * oral or intravenous use of steroids

Keywords: limited disease small cell lung cancer concurrent chemoradiotherapy dose fractionation
iron metabolism disorders in patients with sepsis or septic shock.

Conditions: Iron-deficiency; Iron Deficiency Anemia; Anemia of Chronic Disease; Sepsis; Septic Shock

Summary: anemia is a common health problem. depending on a geographical region, anemia affects even 50% of population. among patients admitted to the intensive care unit (icu) anemia may affect as much as 66% of patients. moreover, many patients develop anemia during the icu stay. in general population the most common cause of anemia is iron deficiency (id). the investigators lack information on the incidence of id and anemia of inflammation (ai) with absolute id (mixed type of anemia: ai + ida) or functional id (ai) in patients with sepsis or septic shock hospitalised in the icu. therefore, the aim of the study is to improve diagnosis of iron deficiency (id) and anemia of inflammation (ai) with absolute id (ai + ida) or functional id (ai) in patients with sepsis or septic shock. id have negative effects on the body and is associated with impaired production of proteins responsible for transport of oxygen in the blood (hemoglobin) and oxygen storage (myoglobin), and impaired immune function. development of anemia is associated with well documented complications: organ hypoxia, myocardial infarction, stroke, infection. replenishment of iron at this early stage may potentially prevent ida. it is advantageous to replenish iron stores in order to avoid these complications, especially in patients with sepsis or septic shock. in ida red blood cell transfusion is not recommended as it leads to other numerous complications. therefore the patients presenting with laboratory results suggesting id will receive divided doses od parenteral iron. monitoring of iron replenishment will be based on a new laboratory parameter- reticulocyte hemoglobin equivalent.


Eligibility criteria:
inclusion criteria: * diagnosis of sepsis or septic shock according to the third international definition and appropriate diagnostic criteria exclusion criteria: * active bleeding * erythrocyte mean corpuscular volume (mcv) above the reference range * diagnosed thalassemia or suspicion of thalassemia based on mentzer index \[9\] * pregnancy

Keywords: ferritin transferrin transferrin saturation hepcidin reticulocyte hemoglobin content parenteral iron
covid-19 simulation education on nursing students

Conditions: COVID-19 Pandemic; Simulation of Physical Illness

Summary: this study aims to determine the effect of simulation education as an approach to patients with covid-19 on nursing students' perception and fear of the covid-19 disease. this study was conducted in a randomized controlled trials with 86 nursing students from a university between november 10 and december 10, 2021.


Eligibility criteria:
inclusion criteria: * nursing student and * agreeing to participate in the study exclusion criteria: * refusing to participate in the study or quitting the study

Keywords: nursing student perception of illness fear of death.
urdu translation and cross-cultural validation of the foot and ankle disability index

Conditions: Ankle Disorders Injuries

Summary: the goal of this cross-cultural validation study is to urdu translate and cross-cultural validation of foot and ankle disability index for the patients with chronic ankle instability. the main question it aims to answer was: • to translate foot and ankle disability index in urdu and to find out the validity and reliability for patients with chronic ankle instability. data collection procedure would be, fadi urdu version was introduced and the patients were asked to fill fadi urdu version. the questionnaire was filled again by the same participants after one week to assess the test retest reliability. questionnaire was conducted to have the best result. after the ethical approval, participants who meet the inclusion criteria and who were free from exclusion criteria were explained about the objectives of this study. only those who gave consent were included in the study.

the foot and ankle are common sources of pain and disability, with approximately 2 million people in the united states per year affected by foot pain. as many as 25% of sports injuries have been attributed to the foot or ankle, with ankle sprains accounting for up to 45% of all injuries in some sports. the foot and ankle disability index (fadi) were designed to assess functional limitations related to foot and ankle conditions. therefore, it is used to assess the patients with chronic ankle instability. the fadi was originally developed in english. it has been translated and validated in italian languages and showed excellent reliability and responsiveness. to cross culturally validate the fadi in urdu, the fadi will be translated in urdu to assess the chronic ankle instability patients to check the instability. convenience sampling technique will be used in this study. a study will be conducted at pakistan sports board lahore including 10 athletes for 1st stage and 50 athelets in 2nd stage. the aim of this study was to translate fadi in urdu and to find out the validity and reliability of urdu version of fadi in patients with chronic ankle instability. reliability and validity of fadi in urdu version was evaluated by calculating cronbach's alpha, intra-class correlation co-efficient and pearson/ spearman rank correlation co-efficient. spss 25 was used for data analysis.

Eligibility criteria:
inclusion criteria: * a history of ankle sprain with pain and/or limping for more than 1 day, * chronic weakness, pain, or instability that they attributed to the initial injury * giving way in the last 6 months. * able to read urdu language exclusion criteria: * bilateral ankle instability * history of ankle fracture * ankle injury within 3 months of participation * history of anterior cruciate ligament injury * history of balance disorder * current participation in supervised physical rehabilitation.
clinical use cases assessment of the gabi system in young children with underlying medical conditions (bridge study)

Conditions: Cardiac Disease; Respiratory Disease; Congenital Cardiac Defect; Cardiovascular Diseases; Chronic Respiratory Disease; Chronic Cardiopulmonary Disease; Premature Infant Disease

Summary: subjects will use the gabi system on a daily basis for 3 months, each time the subject is resting or asleep. the gabi system will recording the spo2, pulse rate, respiratory rate and movements of the subject. the objective of this study is to perform a first assessment of the range of most potentially clinically relevant indications for use of the gabi system for children \< 6 years old with underlying medical conditions. this is performed by asking hcps to review the data measured by the gabi system after taking a medical decision independently from the gabi data and to assess the potential clinical utility of the gabi system. the usability of the system will also be assessed throughout questionnaires filled out by the hcps and by the caregivers. \*during this study, the data collected by the gabi system are not intended to be used by caregivers or hcps to take any (medical) decisions.


Eligibility criteria:
inclusion criteria: 1. infants and children \< 6 years old. 2. subjects who present at least one of the following underlying medical conditions: 1. subjects who underwent a congenital cardiac or cardiopulmonary surgery recently and could benefit from an additional post-surgery monitoring at home, per the investigator's opinion. 2. subjects at risk awaiting surgery. 3. subjects hospitalized following a severe respiratory condition within the past 2 weeks requiring invasive or non-invasive ventilation or oxygen therapy. 4. subjects hospitalized following a severe cardiovascular condition within the past 2 weeks, including severe heart failure, tachycardia or bradycardia. 5. subjects with chronic respiratory disease, such as asthma, developmental or cardiovascular conditions who could benefit from medical monitoring at home, per the investigator's opinion. 6. subjects with chronic respiratory support at home. 7. premature babies who required intensive neonatal care. 8. subjects hospitalized following a brief resolved unexpected event (brue) within the past 2 weeks. 9. a clinical risk identified by the investigator which justifies the potential benefit of having a gabi system used by the subject 3. subject is (or is willing to be) followed up by an hcp of the investigation site during the duration of the study. 4. signed informed consent form prior to performing any study specific procedure. 5. willing and likely (based on the investigator's judgement) to comply with all study requirements. exclusion criteria: 1. weight \< 2.5 kg. 2. subject presenting an anatomical limitation that would prevent the use of the gabi system. 3. subjects presenting a motor disorder that would prevent the use of the gabi system (with the exception of epilepsy ). 4. subjects participating in another interventional clinical study (with the exception of registries), which may have an impact on this study outcomes, based on the investigator's judgement.
bioequivalency study of amlodipine besylate tablets, 10 mg of dr. reddy's under fed conditions

Conditions: Healthy

Summary: the purpose of this study is to determine the pharmacokinetics and bioequivalence of amlodipine besylate formulations under fed conditions.

this study evaluates the pharmacokinetics and bioequivalence of amlodipine tablets 10 mg of dr. reddy's versus norvasc 10 mg tablets administered as 1 x 10 mg tablet in healthy volunteers with a washout period of 14 days.

Eligibility criteria:
inclusion criteria: * healthy subjects between 18 and 45 years of age inclusive. * informed of the nature of the study and given written informed consent. * have a body weight within 15% of the appropriate range as defined in the 1983 metropolitan life company tables and weigh at least 115 (appendix i and appendix ii). exclusion criteria: * if female, the subject is lactating or has a positive pregnancy test at screening and prior to each of the three treatment periods. females must use a medically acceptable method of contraception throughout the entire study period and for one week after the study is completed. medically acceptable methods of contraception that may be used by the subject and/or her partner are: oral contraceptives, progestin injection or implants, condom with spermicide, diaphragm with spermicide, iud, vaginal spermicidal suppository, surgical sterilization of themselves or their partners or abstinence. females taking oral contraceptives must have taken them consistently for at least three months prior to receiving study medication. * hypersensitivity to amlodipine besylate (norvasc®)or related calcium channel blockers). * any history of a clinical condition that might affect drug absorption, metabolism or excretion. * recent history of mental illness, drug addiction, drug abuse or alcoholism. * donation of greater than 500 ml of blood in the past 4 weeks prior to study dosing or difficulty in donating blood. * received an investigational drug within the 4 weeks prior to study dosing. * currently taking any prescription medication, except for oral contraceptives, within the 7 days prior to study dosing or over-the-counter medication within 3 days of study dosing. this prohibition does not include vitamins or -herbal preparations taken as nutritional supplements for non-therapeutic indications as judged by the attending physician. * regular tobacco use in the 6 months prior to study dosing.

Keywords: bioequivalence amlodipine besylate
reduction dead space volume with karydakis modification

Conditions: PILONIDAL SINUS

Summary: the purpose of this study is to reduce the volume of dead space by a modification in kardakis flap procedure and consequently, to reduce the use of drains, wound drainage, seroma and hematoma formation, skin degradation and recurrence rates.

the study was a pilot study of 80 patients. excluding criteria were previous sinüs surgery, active infection, patients who did not accept the procedure and patients under age of 18. after excision of the sinüs volume was measured using a beaker. a flap extending across the cut (karydakis) was prepared in medial edge of the wound, 1 cm deep and 2 to 3 cm to be towards the interior. prepared flap was shifted to the medial and sutured to presacral fascia with vicryl 2/0. to reduce the volume of the dead space formed in the lateral, 5 mm skin was excised along the incision in the flap side. skin was approximated with sutures in the form of intermittent, using 2/0 poliprolen. no drain used. all patients were discharged on postoperative day 1. sutures were removed 2 weeks later. all patients for at least 6 months were followed for wound drainage, seroma and hematoma formation, separation of skin and and recurrence.

Eligibility criteria:
inclusion criteria: * patients older than 18 years * patients who accept the procedure * chronic p.sinüs disease exclusion criteria: * previous sinüs surgery * active infection * patients who did not accept the procedure * patients under age of 18.

Keywords: karydakis modification pilonidal sinus complication