Kornimate/medical-research-clean huggingface dataset:
platelet-rich plasma injections from cord blood + penile traction vs. penile traction alone in patients with peyronie's disease. open-label, single-center randomized study

Conditions: Peyronie Disease; Penile Curvature; PRP Injection; Cord Blood; Randomised Clinical Trial; Penile Injection Therapy

Summary: the goal of this clinical trial is to learn if platelet-rich plasma injections from cord blood (cb-prp) is useful in peyronie disease. the primary goal is evaluation of patient satisfaction at 1 and 3 months after treatment completion using the pdq questionnaire secondary objectives are: * measurement of penile curvature measured with a goniometer with spontaneous erection before and after treatment (1 and 3 months) * measurement of penile length in stretching before and after treatment (1 and 3 months) * evaluation of the improvement in quality of life, through the short-form health survey 12 (sf-12) health status questionnaire and through the hospital anxiety and depression scale (hads) participants will be randomized in two groups: * penile extender alone * penile extender + cb prp injection (1 injection every 15 days - 3 in totalinjections)


Eligibility criteria:
inclusion criteria: * patients with peyronie's disease (ipp) penile curvature greater than 30 degrees (autophotography in erection with goniometer measurement) patients candidates for penile traction age: 18-75 years good health conditions preserved erection (iief \>20) complete blood count with differential and coagulation within the normal range (platelets between 150,000 and 450,000 μl) hiv, hcv, and hbsag negative the fertile partner of the patient randomized to the experimental group must use an acceptable highly effective contraceptive method (oral contraceptives, intrauterine device, abstinence, vasectomized partner) for the entire duration of the study informed consent to the study exclusion criteria: coagulopathies, platelet disorders major active infections previous penile surgery (excluding circumcision and condyloma removal) previous infiltrative therapy or penile traction treatment

Keywords: penile exteder peyronie disease prp cord blood prp
comparison of the effect of supine and prone position on the ultrasonographic airway measurements

Conditions: Airway Edema; Obstructive Sleep Apnea; Respiratory Complication

Summary: the aim of this study is to compare the preoperative and postoperative ultrasonographic measurements of patients undergoing in the prone position and the change in upper airway edema. the secondary aim of the study is to investigate the relationship between osas risk levels determined by the stop-bang score in the preoperative period of the patients participating in the study, and airway ultrasound measurements and postoperative critical respiratory events in the preoperative and postoperative period.


Eligibility criteria:
inclusion criteria:1-american society of anesthesiologists physical status classification (asa) i-ii-iii-iv risk group who will undergo percutaneous nephrolithotomy surgery exclusion criteria: 1. prone position contraindications 2. history of maxillofacial deformity, tumor or trauma, 3. difficult airway history 4. decompensated cardiac, respiratory, hepatic, renal diseases 5. cervical spine fracture 6. patients refusal -

Keywords: airway edema obstructive sleep apnea respiratory complications
immuno-virological characterization of severe h1n1v influenza infection in bronchoalveolar lavage

Conditions: Influenza; Acute Lung Injury; Acute Respiratory Distress Syndrome

Summary: the influenza a/h1n1v pandemic virus causes severe pneumonia that can lead to acute respiratory distress syndrome and death even in healthy young individuals. the respective roles of viral replication, bacterial infection and immune alterations of the host during such severe influenza h1n1v infection need to be clarified in order to optimize patients care. in this context, we aim to study immune and virological parameters in bronchoalveolar lavage fluid during severe influenza a/h1n1v infection with pulmonary involvement in intensive care unit. results will be correlated to bacterial or viral pulmonary co-infections and to peripheral blood immune and virological parameters.


Eligibility criteria:
inclusion criteria: * suspected influenza a/h1n1 infection * diffuse bilateral pneumonia \<96h with acute lung injury or respiratory distress syndrome * invasive or non-invasive ventilation in intensive care unit * age \> 13 exclusion criteria: * other cause identified of acute lung injury or acute respiratory distress syndrome * contraindicated bronchoalveolar lavage

Keywords: influenza h1n1 lymphocytes t cell cd4 cd8 cytokine serology broncho-alveolar lavage acute respiratory distress syndrome ventilation intensive care unit
explain pain in fibromyalgia patients

Conditions: Fibromyalgia

Summary: education of pain physiology is described as an educational session or sessions describing the neurobiology and neurophysiology of pain, and pain processing by the nervous system. there is compelling evidence that an educational strategy addressing neurophysiology and neurobiology of pain can have a positive effect on pain, disability, catastrophization, and physical performance in chronic musculoskeletal pain disorders. although pain physiology education has been studied in patients with chronic low back pain, chronic whiplash, and chronic fatigue syndrome in combination with widespread pain, studies in fibromyalgia (fm) are limited to a 2013 study with limited results. the investigators propose a study with a higher dose of education of pain physiology (i.e. a higher number of educational sessions and total education time) to study if this generates a larger treatment effect in patients with fibromyalgia.


Eligibility criteria:
inclusion criteria: * american college of rheumatology classification criteria for fm, both 1990 and 2010 * reported average pain intensity ≥ 4 on a 0 to 10 cm visual analogue scale based on 1 week of daily pain diaries * on stable doses of medications for fm ≥ 4 weeks exclusion criteria: * suffer from an inflammatory rheumatic conditions * have a planned elective surgery during the study period * have ongoing unresolved disability claims * experience symptoms of bipolar disorder, major depressive disorder, panic disorder, or psychosis * do not speak spanish fluently

Keywords: fibromyalgia patient education central sensitization
evaluating investigational medical device for breast tumor diagnosis using diffusion optical spectroscopy

Conditions: Breast Cancer; Breast Tumor; Mammary Carcinoma, Human

Summary: this is a multicenter, pivotal clinical trial to evaluate the safety and efficacy of a diagnostic device used to assist in the differentiation of breast tumors in patients with breast lesions detected by ultrasound alone or by both ultrasound and mammography.


Eligibility criteria:
inclusion criteria: * female aged 19 years or older * acr bi-rads category 3-5 (5th edition, 2023 update) exclusion criteria: * pregnant, potentially pregnant, or currently breastfeeding * calcifications detected on mammography but do not have corresponding lesions identified on ultrasound * biopsy performed on the same breast within 7 days prior to the date of informed consent * significant trauma or scarring at the measurement site, or those suffering from mastitis. * breast implants, electronic medical devices such as pacemakers, or with a space left in the breast cavity due to implant removal * history of phototoxic reactions or light sensitivity
research on accurate prediction of long-term medication use for schizophrenia based on cognitive function

Conditions: Non-medicine Intervention

Summary: chinese version of the cognitive function test of schizophrenia (mccb) . to explore a predictive model for long-term medication use in patients based on cognitive function


Eligibility criteria:
inclusion criteria: * schizophrenia patients with first episode and disease duration of 5, 10, 20, and 30 years _meet the diagnostic criteria for schizophrenia in icd-10 exclusion criteria: * other people with mental illness
to assess the correlation of high-resolution specimen pet-ct imaging, using the xeos aura 10 pet-ct, with the histopathology results and long-term outcome of patients undergoing resective cancer surgery.

Conditions: Prostate Cancers; Breast Cancer; Head and Neck Cancer; Cancer

Summary: this registry study aims to evaluate the effectiveness and clinical impact of specimen pet-ct imaging by analyzing the correlation between specimen pet-ct images, intraoperative interpretations, and histopathological findings. additionally, it assesses how these imaging insights influence clinical decision-making and long-term patient outcomes. through this comprehensive analysis in a real-world setting, the study seeks to generate valuable insights that can enhance specimen evaluation processes and ultimately improve patient care.


Eligibility criteria:
inclusion criteria : all patients that were scheduled for resective surgery and for whom successful high-resolution pet-ct imaging was performed on their resected specimens using the aura 10 pet-ct. successful imaging means that the image contains at least a portion of the primary tumor, the radiotracer injection was correctly executed and there were no technical issues that lead to an uninterpretable pet-ct image. or all patients that are scheduled for resective surgery and for whom high-resolution pet-ct imaging will be performed on their resected specimens using the aura 10 pet-ct. patients willing to provide informed consent for use of their relevant medical records. for retrospectively included patients with no further long-term follow-up (ltfu) data collection, a notification will be sent. exclusion criteria: * under the age of 18 years at the time of resective surgery. * women who are pregnant or breastfeeding.

Keywords: pet-ct registry imaging cancer
echocardiography during ajmaline test

Conditions: Brugada Syndrome

Summary: in this study the investigators analyse echocardiographic images before and during ajmaline test. the purpose is to know if any echocardiographic modifications are present during either negative or positive ajmaline testing.

the diagnosis of brugada syndrome is made when a type 1 pattern is present on the electrocardiogram (ecg), either spontaneously or after administration of a sodium channel blocker. for pathofysiological understanding, the investigators will analyse echocardiography images before and during the administration of ajmaline. comparing echocardiographies before and during negative ajmaline test, will allow the investigators to indentify the effect of ajmaline administration on cardiac function. the comparison between images of negative and positive ajmaline tests will expose differences related to the occurence of a type 1 ecg.

Eligibility criteria:
inclusion criteria: * \>17 years old * clinical indication for ajmaline test exclusion criteria: * history of right ventricular outflow tract ablation

Keywords: ajmaline test
optimal palliative anti-epidermal growth factor receptor treatment in metastatic colorectal cancer -

Conditions: Colorectal Cancer Metastatic; Circulating Tumor DNA; KRAS Gene Mutation; NRAS Gene Mutation; BRAF Gene Mutation; Epidermal Growth Factor Receptor Inhibitor

Summary: the present study will investigate the feasibility and clinical value of using circulating tumor dna as selection for anti-epidermal growth factor receptor treatment for metastatic colorectal cancer.

the primary aim of this prospective study is to investigate if cfdna in plasma is feasible and reliable for selection of mcrc patients who will benefit of anti-egfr monoclonal antibody therapy secondary, to analyze developments in mutational status as reflected by cfdna in plasma during therapy and at time of progression

Eligibility criteria:
inclusion criteria * histopathologically verified metastatic colorectal cancer * indication for systemic palliative treatment with standard anti-egfr monoclonal antibodies * fit for therapy with egfr inhibition * consent to treatment and sampling * measureable disease according to recist v 1.1 * age ≥ 18 exclusion criteria * ps \> 2 * significant other cancer disease within 5 years of inclusion * conditions precluding sampling during therapy and treatment breaks.
factors predict difficult colonoscopy before the procedure: prospective registry study

Conditions: Colonoscopy

Summary: in this study, the investigators aim to evaluate the relationship between cecal intubation time during colonoscopies and factors such as the patient's age, body mass index, history of constipation, wexner constipation score, antidepressant use, and previous abdominal surgery. the objective is to assess factors that may predict longer cecal intubation times, especially in difficult colonoscopies. prior to the procedure, informed consent will be obtained from patients scheduled for colonoscopy in the surgical endoscopy unit, and relevant information will be recorded. during the procedure, data will be collected, including cecal intubation time, if ileal intubation is performed, and the total procedure time.

this study is designed as a prospective single-center registry study and has been approved by the ethics committee of sisli hamidiye etfal training and research hospital on may 30, 2023. the inclusion criteria for study involve patients scheduled for colonoscopy in surgical endoscopy unit who have not undergone colorectal surgery. following informed consent obtained from patients before colonoscopy, data forms prepared by investigators will be completed, evaluating patients' age, height, weight, body mass index, colonoscopy indication, antidepressant use, and history of abdominal surgeries. additionally, the wexner constipation score will be calculated for each patient. the time taken to reach the cecum and, if intubated, the ileum, from the initial insertion of the endoscope in colonoscopy, as well as the total procedure time, will be recorded using a chronometer. patients with inadequate bowel preparation preventing cecal intubation will be excluded from the study. the collected data will be analysed to assess factors prolonging cecal intubation time and, if possible, to identify predictors for difficult colonoscopy before procedure.

Eligibility criteria:
inclusion criteria: * 18-95 years old, admitted for colonoscopy exclusion criteria: * colonic resection history

Keywords: colonoscopy constipation cecal intubation time
a study to evaluate the efficacy of sage-217 in the treatment of adult participants with major depressive disorder

Conditions: Major Depressive Disorder

Summary: this study is a phase 3, multicenter, double-blind, randomized, placebo-controlled study evaluating the efficacy of sage-217 in the treatment of adult participants with major depressive disorder (mdd).

this study was previously posted by sage therapeutics. in november 2023, sponsorship of the trial was transferred to biogen.

Eligibility criteria:
inclusion criteria: 1. participant had a diagnosis of mdd with symptoms that had been present for at least a 4-week period. 2. participant had a montgomery-åsberg depression rating scale (madrs) total score of ≥32 and a 17-item hamilton rating scale for depression (ham-d) total score ≥22 at screening and day 1 (prior to dosing). exclusion criteria: 1. participant had active psychosis. 2. participant had attempted suicide associated with the current episode of mdd. 3. participant had a medical history of bipolar disorder, schizophrenia, and/or schizoaffective disorder.
a study to evaluate the safety of cnto 2476 in patients with advanced retinitis pigmentosa

Conditions: Retinitis Pigmentosa

Summary: the main purpose of this study is to evaluate the preliminary safety and immunogenicity (ability of an antigen to provoke immune response in the human body) of cnto 2476, administered subretinally, in participants with advanced retinitis pigmentosa (rp; disease of the eye that leads to loss of vision and blindness) with either light perception only (lp) or hand motion (hm).

the study will be an open-label (all people know the identity of the intervention), first in human safety study. nine adult men and women with advanced rp with lp only (first 5 participants) or not better than hm bilaterally (subsequent 4 participants) in both eyes will be enrolled. participant 5 may have combination visual acuity of lp in the treated eye and no better than hm in the fellow eye. treatment will proceed on a cohort basis ie, cohort i: participant 1; cohort ii: participant 2; cohort iii: participant 3 and 4; cohort iv: participant 5, 6, and 7; and cohort v: participant 8 and 9. the initial participants for each cohort must have completed at least 4 weeks of post-treatment follow-up before participants in the next cohort may be treated. there are 2 safety assessment phases in this study: the main phase approximately 12 months from the time the participant is eligible to enter the study and the long-term safety follow-up phase of 4 additional years. the total length of the participation in the study could last up to 5 years (including both the main and safety follow-up phases).

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of retinitis pigmentosa that is not part of another systemic disease * vision deficit characterized by vision that is not better than either light perception (group 1) or hand motion (group 2) in both eyes * normal hematology and chemistry lab results * participant is suitable candidate for ophthalmologic surgery exclusion criteria: * other significant ophthalmologic diseases or any other ophthalmologic condition that interferes with ophthalmologic examination * women of childbearing potential * ocular hypertension * other serious medical conditions

Keywords: retinitis pigmentosa advanced retinitis pigmentosa (rp) cnto 2476 subretinal human umbilical tissue-derived cells (hutc) light perception (lp) hand motion (hm)
neurophysiological dissection and intervention of freezing of gait in parkinson's disease

Conditions: Parkinson's Disease With Freezing of Gait

Summary: different conditions of gait ignition freezing, spontaneous freezing during walking and turning freezing on encountering obstacle will be investigated in fmri study to examine whether different regions of brain will be involved under different conditions of freezing. we hypothesize that anterior cortical regions will engage in gait ignition failure, deep locomotion regions will be responsible for spontaneous freezing and schema regions will be involved in the generation of turning freezing on seeing the barrier. in the third part of the project, we will deliver a 5-day session of transcranial direct current stimulation (tdcs) to the motor cortex of the fog patients to examine whether the intervention will benefit the patients. based on the signal source findings, we will investigate whether the possible tdcs beneficial effect will be different or similar in patients with different electric sources. in addition, how long the possible beneficial effect of tdcs can be consolidated after the 5-day course of stimulation is crucial and requires to be elucidated under the research project. we aim to peep the myth of fog in pd by the multi-modality approach and hope the study will benefit the long suffering patients.


Eligibility criteria:
inclusion criteria: the diagnosis of freezing of gait will be made by the following criteria: 1. without video:is there any feeling that your feet are transiently glued to the floor while trying to initiate walking, making a turn or when walking through narrow spaces or in crowded places? (sometimes it can be accompanied with trembling of the legs and small shuffling steps.) 2. additional instructions with video:we will watch a short video together to see the many ways in which freezing can occur. also, look carefully for how long these episodes last, as you can expect some questions on this later. 3. patient is diagnosed to have freezing of gait if "i have experienced such a feeling or episode over the past month" was answered. exclusion criteria: 1. impairment of cognition that leads unable to fully cooperate with the oral commands during examinations. 2. moderate to severe medical disorders such as functional iii or above congestive heart failure, or cancer with distant metastasis etc. 3. hoehn and yahr stage 5.

Keywords: parkinson's disease freezing of gait electrophysiology magnetic resonance image direct current stimulation
rasecal-bronchoscopic ambusampler

Conditions: Respiratory Failure

Summary: prospective, multi-centre, open labelled, 1:1randomized controlled study.

1. patients admitted to icu with acute respiratory failure, requiring mechanical ventilation with, suspected or confirmed covid-19. 2. patients admitted to icu with acute respiratory failure due to a condition other than covid-19, requiring mechanical ventilation.

Eligibility criteria:
inclusion criteria: (all are required) * clinicians experienced in performing bronchoscopies (i.e. bronchoscopists should have performed a minimum 5 bronchoscopies in mechanically ventilated patients and a minimum of 5 bronchoscopies in a simulated or practice setting). * clinicians who have undergone the online product-training module for the use of the ambu bronchosampler, with self-certification documented. * clinicians who have simulated the online product training module using an ambu bronchosampler and ambu ascope4 a minimum of 5 times in a practice setting and have self-certified. population * patients ≥ 18 years old * patients on mechanical ventilation with acute respiratory failure for \>4h * patients eligible for a clinically indicated bronchoscopy with fluid sampling. patient information has been explained and verbal or written consent has been obtained exclusion criteria: investigators * investigators who have not completed product training in ascope bronchosampler by online and hands-on from ambu product specialists or an experienced user from the site. * investigators with experience in \< 5 self-verified simulated fluid sampling procedures using the ambu bronchosampler 4.8.2 population * clinician concern regarding safety of bronchoscopy * involved study personal not available to perform the procedure and enroll the patient
intranasal esketamine and fentanyl for pain in minor trauma

Conditions: Acute Pain Due to Trauma

Summary: intranasal esketamine, fentanyl and placebo are compared in treatment of acute pain in adult patients with minor trauma. study is blinded randomized placebo-controlled parallel design.


Eligibility criteria:
inclusion criteria: * nrs 5 or more, minor trauma, no need for immediate iv cannulation, weight 45-115 kg exclusion criteria: * pregnancy, breastfeeding, head trauma, severe chronic obstructive pulmonary disease (copd), gfr under 30, liver cirrhosis, mental illness other than mild/moderate depression, sleep apnea, unstable coronary artery disease (cad), unstable heart failure (hf), intoxication, untreated hypertension, dementia, do not understand finnish, contraindication to nasal spray, allergy to any of the medications, bradycardia, desaturation, suspected high intracranial pressure (icp)

Keywords: fentanyl esketamine ketamine analgesia acute pain minor trauma