Kornimate/medical-research-clean huggingface dataset:
a prospective randomized trial of efficacy of stump closure for distal pancreatectomy

Conditions: Pancreatic Fistula

Summary: overall morbidity rate remained high after distal pancreatectomy (dp), ranging from 30% to 60%. whilst postoperative pancreatic fistula (popf) remains serious and also is one of the most common complications after dp (12% to 40%). popf after dp is also associated with major complications such as bleeding or septic shock and remains an equivocal problem. however, all the previous reports were retrospective review, non-randomized study, or individual experience and showed no significant improvement of overall popf. as always, this issue remains in obscurity and seek for a more concrete evidence to solve.

pancreatic surgery has been called formidable operation not only the technical challenge to surgeons but also demanding for patients. it evolved into a safe procedure with mortality rates of \<5% recently, cutting down gradually from 25% in the 1960s. however, overall morbidity rate remained high ranging from 30% to 60%. distal pancreatectomy (dp) has been believed a safer and minor procedure compared with pancreatic head resection including standard pancreaticoduodenectomy (pd), pylorus-preserving pancreaticoduodenectomy (pppd), or duodenum-preserving pancreatic head resection (dpphr). whilst postoperative pancreatic fistula (popf) remains serious and also is one of the most common complications after dp. büchler et al observed that the popf rate was in fact significantly higher after dp when compared to pancreatic head resections. the variable documented incidence of popf following dp ranges from 12% to 40%. popf after dp is also associated with major complications such as bleeding or septic shock and remains an equivocal problem. although the majority of complications are not life-threatening, popf could prolong hospitalization, expend expenditure for healthcare, abrade the quality of life; moreover, delay in further management for a fraction of patients with malignancy. over the past two decades, various risk factors and multitudinous operative procedures have been held for reduction popd following dp. these include underlying disease process, method of stump closure, and concomitant splenectomy however, all these reports were retrospective review, non-randomized study, or individual experience. as always, this issue remains in obscurity and seek for a more concrete evidence to solve.

Eligibility criteria:
inclusion criteria: * age\>= 20 years * scheduled distal pancreatectomy at ntuh * unable to realize this trial and willing to sign the informed consent form exclusion criteria: * age\< 20 years, pregnent women, breast-feeding women, or mentally illed * active malignancy within 2 years * received other upper abdomen major surgery * scheduled spleen preservation or associated major organ resection

Keywords: distal pancreatectomy pancreatic fistula oxidized regenerated cellulose pancreatectomy
sexual dysfunction, disability and quality of life in patients with multiple sclerosis (ms)

Conditions: Multiple Sclerosis, Relapsing Remitting

Summary: this is an observational, prospective, non-interventional, non-controlled study planned to be conducted in subjects with relapsing-remitting multiple sclerosis (rrms). the purpose of this observational study is to determine the correlation between the degree of disability and sexual dysfunction; and between the sexual dysfunction and the quality of life (qol) of subjects with relapsing remitting multiple sclerosis (rrms) in argentina.

multiple sclerosis, like most of the chronic diseases, can affect the sexuality of those who suffer from it. this situation has an evident and marked impact on the qol of the subjects and his/her partner, and causes conflict in the relationship, with high levels of mutual dissatisfaction. the impact that the duration of the disease or the degree of disability have on the level of sexual dysfunction is not clear. however, the possible organic and state of mind causes of the sexual dysfunction makes us think that the degree of disability is a crucial factor in the genesis and duration of the symptoms in the sexual area. the frequency with which the sexual dysfunction is detected or referred in these subjects is variable. the sexual dysfunction in subjects with ms is typically characterized by a decreased libido, erectile dysfunction and ejaculation disorders in men, and decreased lubrication and anorgasmia in women. the most commonly detected problems are the erectile dysfunction and/or lack of sexual interest in men and lack of interest, decreased libido and orgasmic disorder in women. this observational study aims to assess a population of subjects with ms that show symptoms of sexual dysfunction, in order to determine the relationship, if any, between the severity of the general disability and the incidence of sexual dysfunction. at the same time, this epidemiologic study aims to measure the impact the sexual dysfunction generates in the quality of life of subjects with ms. the data to be obtained could contribute to a better understanding of the relationship between the studied variables and, eventually, to alert the treating doctors about the incidence of these morbid associations. the total duration of the study is 24 months. the recruiting period will be 12 months. once the recruiting time is over, the collection of data will continue during the full 24 months period that was planned.

Eligibility criteria:
inclusion criteria: * men and women \> 21 years of age * subjects with established diagnosis of rrms according to the revised mcdonald criteria - 2005 * subjects with a diagnosis of rrms for more than one year * the subject who have signed the informed consent exclusion criteria: * subjects with no sexual experience * subjects with other diseases associated to ms * subjects with psychiatric diseases that could cause sexual dysfunction * subjects with one relapse during the previous month * use of antidepressants and/or corticosteroids during the previous month

Keywords: multiple sclerosis, relapsing remitting sexual dysfunction
tranexamic acid versus blood stopper treatments in epistaxis management

Conditions: Epistaxis Nosebleed

Summary: in this randonmized controlled trial, aim to compare the effectiveness of local administration of tranexamic acid and blood stopper (ankaferd®) on cessation of bleeding in epistaxis patients.

anterior tamponade is frequently used in the management of anterior epistaxis. however, this procedure is often uncomfortable for patients. therefore, instead of this physical tampon, various pharmacologic agents such as tranexamic acid, blood stoppers (ankaferd®), and adrenaline can be used in epistaxis management. although the superiority of various agents used in the management of anterior epistaxis has been evaluated in published network meta-analyses, these meta-analyses do not compare ankaferd and tranexamic acid since there are no studies with each other. in order to close the gap in the existing literature, this study aims to evaluate the superiority of local administration of tranexamic acid and ankaferd® in terms of cessation of bleeding in patients with anterior epistaxis.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age with epistaxis will present to the emergency department with non-traumatic epistaxis and whose bleeding do not stop with simple external compression for 10 minutes. exclusion criteria: * patients demonstrating hemodynamic instability * patients with documented allergy to tranexamic acid or ankaferd * patients with known bleeding disorders, * patients using anticoagulants, * pregnant patients

Keywords: epistaxis nosebleed ankaferd tranexamic acid
expansion of invariant nkt cells for a cell immunotherapeutic approach allowing the control of graft versus host-disease and preserving the graft versus leukemia effect after allogeneic hematopoietic stem cell transplantation

Conditions: Allogeneic Hematopoietic Stem Cell (HSC) Transplantation

Summary: allogeneic hematopoietic stem cell (hsc) transplantation remains the most efficient cellular immunotherapeutic approach for the treatment of myeloid hematological malignancies. however, its use is hampered by the risk of developing acute graft-versus-host disease (agvhd). invariant nkt cells (inkt) represent a good candidate of immuno-regulatory cells that could control gvhd while preserving the anti-leukemic effect (gvl) of hsct. our team have shown that higher numbers and expansion capacity of cd4- inkt cells contained in the hsc graft were associated with reduced risk of agvhd but preserved gvl effect and that some healthy donors have low numbers and expansion capacity cd4- inkt cells 1. the objective of this project is to develop a strategy allowing to expand human cd4- inkt cells from healthy donors of hsc grafts that would be transposable to gmp-validated cell production. our team proposes to first determine the best strategy to expand the cd4- inkt cell subset from g-scf mobilized peripheral blood stem cells (pbsc) obtained from healthy donors, at little scale using cultures gmp validated conditions, by comparing the convention expansion protocol using il-2 alone to il-7, il-15, il-4 or combination of those cytokines involved in the expansion of t cells and by culturing the cells in a bioreactor. our team will then explore the characteristics of cells after expansion in terms of phenotype, transcription signature and functions in vitro (in mixed lymphocyte reaction) and in vivo in a well-established xenogeneic model of gvhd.


Eligibility criteria:
inclusion criteria: hematopoietic stem cells : * from major donors after mobilization by g-csf, informed of the research and not having opposed it * collected after verification by the cell therapy centre of the presence of a sufficient quantity of csh for transplantation exclusion criteria: hematopoietic stem cells (hscs) from donors seropositive for hiv, hcv, htlv1 and hbv (except post-vaccination profile)

Keywords: cell therapy immuno-modulation immunotherapy hematology
a dispensing clinical trial of comfilcon a extended range multifocal lenses

Conditions: Presbyopia

Summary: the aim of this study is to validate the clinical of comfilcon a extended range high add center near (cn) multifocal lenses in existing contact lens wearers against the current comfilcon a high add multifocal lenses.

this study is a 13-subject, randomized, prospective, single site, daily wear, single-masked (to the subject), bilateral, 4-day cross-over, dispensing study comparing the comfilcon a extended range multifocal test lens against the comfilcon a multifocal control lens.

Eligibility criteria:
inclusion criteria: a person is eligible for inclusion in the study if he/she: * has had a self-reported oculo-visual examination in the last two years * is 50 years of age or greater and has full legal capacity to volunteer * is able to read and understand the informed consent * is willing and able to follow instructions and maintain the appointment schedule * has a spherical distance contact lens prescription between -1.00 and -5.00d (diopters) (inclusive) * near add power requirement of +2.25d or greater * has spectacle cylinder 0.75 d in both eyes * has normal binocularity (no amblyopia, no strabismus, no habitually uncorrected anisometropia ≥ 2.00d) * has monocular best-corrected distance visual acuity of 20/30 or better in each eye * has clear corneas and no active ocular disease * has not worn gas permeable contact lenses for 1 month prior to the study exclusion criteria: a person will be excluded from the study if he/she: * has never worn contact lenses before * has any systemic disease affecting ocular health * is using any systemic or topical medications that will affect ocular health * has any ocular pathology or abnormality that would affect the wearing of contact lenses * is aphakic (i.e. missing their natural lens inside their eye) * has uncorrected anisometropia (i.e. difference in the prescription between the eyes) of ≥2.00 d * has undergone corneal refractive surgery * is participating in any other type of eye related clinical or research study.
amg 510 ethnic sensitivity study (codebreak 105).

Conditions: Advanced/Metastatic Solid Tumors With KRAS p.G12C Mutation

Summary: to evaluate safety, tolerability, pk, and preliminary efficacy of amg 510 po qd in subjects of chinese descent with kras p.g12c-mutant advanced/metastatic solid tumors.


Eligibility criteria:
inclusion criteria * male or female subjects greater than or equal to 18 years old * subject is of chinese ancestry * pathologically documented, advanced/metastatic solid tumor with kras p.g12c mutation identified exclusion criteria: * active brain metastases from non-brain tumors. * myocardial infarction within 6 months of study day 1. * gastrointestinal (gi) tract disease causing the inability to take oral medication

Keywords: amg510 phase 1 chinese descent advanced solid tumors kras p.g12c mutation
children's familiarity with snack foods changes expectations about fullness

Conditions: Children

Summary: the purpose of this study was to measure and quantify children's beliefs about the satiating properties (i.e. expected satiation)of snack foods. the investigators predicted that children who were especially familiar with snack foods would expect them to deliver greater satiation.

palatability is regarded as a major determinant of children's energy intake. however, few studies have considered other "non-hedonic" beliefs about foods. in adults there is emerging evidence that expectations about the satiating properties of foods are an important determinant of meal size, and that these beliefs are learned over time. in the current study, we measured and quantified children's 'expected satiation' across energy-dense snack foods using a psychophysical technique known as method of adjustment. participants changed a comparison-food portion (pasta and tomato sauce) to match the satiation that they expected from a snack food. we predicted that children who were especially familiar with snack foods would expect them to generate greater satiation, and that children who were unfamiliar would match expected satiation based on the physical characteristics (perceived volume) of the foods. in our study, seventy 11- to 12-year-old children completed computerised measures of expected satiation, perceived volume, familiarity, and liking across six snack foods. our analyses focused on the associations between these measures. this approach enabled us to establish differences in healthy behaviours that are evident across individuals.

Eligibility criteria:
inclusion criteria: * aged 11 to 12 years * english speaking * normal or corrected-to-normal vision exclusion criteria: * none

Keywords: obesity child dietary habits
pancreatic exocrine insufficiency after bariatric surgery

Conditions: Obesity, Morbid; Pancreatic Insufficiency

Summary: main proposed benefit of sleeve gastrectomy is loss of ghrelin secreting tissue. some studies express that ghrelin augment pancreatic regeneration. therefore we hypothesized that with sleeve gastrectomy it may result with pancreatic insufficiency.

mechanism of weight loss differs in bariatric surgery according to type of surgery. with sleeve gastrectomy which has restrictive mechanism, ghrelin excretion decreases, and this condition is attributed as an additional mechanism in weight loss. ghrelin effects pancreatic regeneration, and loss of ghrelin may result with pancreatic insufficiency. therefore we aimed to deteremine this association.

Eligibility criteria:
inclusion criteria: patients underwent bariatric surgery (sleeve gastrectomy) after concordonce with nih criteria exclusion criteria: additional operations to sleeve gastrectomy like duodenal switch. other bariatric operations.
ventricular tachyarrhythmia (vt) storm, gene expression in implantable cardioverter defibrillator (icd) patients with electrical storm

Conditions: Arrhythmias

Summary: the purpose of the proposed pilot study is to identify factors which are associated with periods of high ventricular arrhythmia burden. this will be performed by analysis of gene expression from peripheral blood samples.

this is a study of patients with icd implants who present with multiple(\>2), low-level(1-2) or inappropriate therapies to their defibrillator. the purpose of this pilot study is to identify factors which are associated with periods of high ventricular arrhythmia burden by looking at gene expression from peripheral blood, in addition to levels of known markers of chf, including catecholamine levels, b-type natriuretic peptide, and troponin. this study hypothesizes that extrinsic or systemic factors play a role in triggering these events, and if true should yield candidate proteins which would spawn functional studies to prove a role in causation. additionally, identification of a marker of increased recurrence of events may aid in guiding therapy (starting an anti-arrhythmic versus awaiting the next event).

Eligibility criteria:
inclusion criteria: * icd patients at least 18 years of age that present within a 72 hour period: 1) \> 2 therapies for ventricular arrhythmias; 2) 1-2 therapies for ventricular arrhythmias; 3) inappropriate therapies for ventricular arrhythmias * able to give informed consent exclusion criteria: * inability to give informed consent

Keywords: ventricular arrhythmias icd vt storm icd patients with vt storm
study of non-inferiority between manzanilla sophia® and meticel ofteno® 0.5% for providing a soothing sensation to the eyes.

Conditions: Eye Strain; Eye Strain of Both Eyes

Summary: this is a phase iv clinical study to demonstrate the non-inferiority of manzanilla sophia® compared to meticel ofteno® 0.5% in providing restful sensation to the eyes. this will be evaluated by measuring the incidence of unexpected adverse events related to the interventions, the incidence of conjunctival hyperemia and the incidence of sensation of comfort with the application, when applied by the principal investigator (pi).

primary: -analog visual eyestrain test score secondary: * incidence of unexpected adverse events related to the interventions * incidence of conjunctival hyperemia * incidence of sensation of ocular dryness * incidence of ocular irritation * incidence of sensation of (sleep-crust) * incidence of sensation of comfort with the application, when applied by the principal investigator (pi)

Eligibility criteria:
inclusion criteria: * having the ability to voluntarily give their signed informed consent. * being able to and willing to comply with scheduled visits, treatment plan, and other study procedures. * age ≥18 years. * women of childbearing potential who have not undergone bilateral tubal occlusion (bto \[tubal ligation\]), hysterectomy, or bilateral oophorectomy must ensure continuation (initiated ≥ 30 days prior to signing the informed consent form \[icf\]) of the use of a hormonal contraceptive method or intrauterine device (iud) during the study period. * present on the analog visual eyestrain test score ≥ 3 on at least 4 of the included questions. exclusion criteria: * history of hypersensitivity to any of the components of the drugs under investigation. * use of contact lenses for a period less than two weeks prior to the start of the study, and during the intervention period of this study. * in the case of women: being pregnant, breastfeeding, or planning to become pregnant within the study period. * having participated in any clinical research study 30 days prior to inclusion in this study. * having previously participated in this same study. * having a single functional eye. * having a history of drug addiction or drug dependence current or within the last two years prior to signing the informed consent. elimination criteria: * withdrawal of their consent to participate in the study (informed consent form). * occurrence of a serious adverse event, whether related or not to the interventions, that in the opinion of the principal investigator (pi) and/or the sponsor, could affect the patient's fitness to safely continue with the study procedures. * non-tolerability or hypersensitivity to any of the drugs under investigation.
effects of stationary cycling and progressive functional training in cerebral palsy children

Conditions: Cerebral Palsy

Summary: cerebral palsy is not a progressive disease but movement problem and musculoskeletal disorders in cerebral palsy change with time. children with cp usually with the lower limb involvement presents with muscle weakness, limited muscular control which results in muscular insufficiency, coordination and balance impairment. these impairments effect the normal activities of child in daily living. there are many children who have good cognition but poor lower limb coordination which is leading cause of disability in them and multiple factors are responsible for them like lake of awareness in parents, no time, expensive therapy program and inappropriate techniques.

the study will be randomized clinical trial and will be conducted in bahawalpur. the study will be completed in time duration of 6 months after approval of synopsis. non probability convenience sampling technique will be used and 22 children will be recruited in the study meeting the inclusion criteria. the participants will be divided into two groups through randomization using lottery method. group a will perform 10-15 minutes of stationary cycle training, 3 times a week for 6 weeks. while group b will be given progressive functional training 3 times a week for 10-15 minutes for 6 weeks. pediatrics balance scale will be used to measure functional balance skills and gmfs scale will be used to measure gross motor function. the data will be assessed at the baseline and after 6 weeks of intervention. after data collection data will be analyzed by using spss version 25.

Eligibility criteria:
inclusion criteria: * • children with cerebral palsy (hemiplegic) * age: 4 to 10 years * able to sit without foot or arm support * children with level i \& ii on gross motor function classification system * normal cognitive function; can understand and follow command exclusion criteria: * • children with mental retardation. * visual and auditory disorders. * history of any surgical procedure. * any infections, unstable seizures, etc. * fixed deformities or contractures of lower limbs.

Keywords: : balance, cerebral palsy, cycling, motor control functional training,