Kornimate/medical-research-clean huggingface dataset:
effect of periodontal treatment on adipokine levels

Conditions: Periodontitis; Diabetes Mellitus, Type 2

Summary: the present study aimed to determine the effect of non-surgical periodontal treatment (nspt) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 diabetes mellitus (t2dm).

the present study aimed to determine the effect of non-surgical periodontal treatment (nspt) on serum and salivary adipokine and interleukin (il)-1β levels in periodontitis patients with or without type 2 diabetes mellitus (t2dm). a total of 80 patients; 20 healthy, 20 t2dm with periodontitis (p), 20 t2dm periodontally healthy, 20 systemically healthy with p were included in this study. at baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. periodontitis patients received nspt in 4 sessions. clinical parameters were re-measured and samples were re-collected at 1 and 3 months after treatment. serum and salivary levels of adipokines and il-1β were analyzed using a flow cytometry-based technique of lumina® map™. data were analyzed using appropriate statistical tests.

Eligibility criteria:
inclusion criteria: * diabetes mellitus should be diagnosed for ≥1 year and hba1c level should be at least %6,5 * periodontitis should be diagnosed for at least 4 teeth with probing depth ≥5 mm with bleeding on probing (bop) and also radiographic alveolar bone loss should be presence * presence of at least 15 teeth exclusion criteria: * received antibiotic treatment in the previous 3 months * smokers * pregnancy and lactation * received periodontal treatment in the previous 6 months * presence of less than 15 teeth * having major diabetic complications

Keywords: adipokines diabetes mellitus inflammation periodontitis
analgesic efficacy of serratus anterior plane block in the rib fractures pain

Conditions: Serratus Plane Block

Summary: serratus anterior plane block (sapb) is a facial plane block that was first described by blanco in 2013 and that blocks the lateral cutaneous branches of the t2-t9 intercostal nerves, the intercostobrachial nerve, n. thoracic longus, n. thoracodorsalis nerves. case and case series have been reported in the literature on the use of sapb in rib fractures, and it has been reported as an effective analgesia method. we apply sapb to patients with rib fractures with pain in our clinic. our aim is to evaluate sapb for patients with rib fractures pain and to compare them with the control group in terms of total analgesic consumption and pain scores.

after ethics committee approval patients with rib fracture pain and have a numerical rating scale (nrs) score of ≥ 4, included the study. the patients were randomized by the closed envelope method. the patients were divided into two groups as the sapb-performed group (group s) and the control group (group k). intravenous patient-controlled analgesia (pca) device prepared with tramadol was applied to all patients.

Eligibility criteria:
inclusion criteria: rib fracture pain and had a numerical rating scale (nrs) score of ≥ 4 asa i-ii-iii exclusion criteria: patients with infection at the injection site coagulopathy allergy to amide-type local anesthetics history of peripheral neuropathy hepatic and/or renal failure refusing the procedure
acute coronary syndrome and nurse counselling

Conditions: Acute Myocardial Infarction; Coronary Artery Disease

Summary: the goal of this clinical trial is to examine in patients with acute coronary syndrome. the main questions it aims to answer are: * does nurse counseling affect quality of life? * does nurse counseling affect functional capacity? * does nurse counseling affect knowledge, attitudes and beliefs about syndromes? participants will be trained using the training booklet, and nursing counseling will then be provided for six months. if there is a comparison group: researchers will compare with the control group to see if the nurse counseling has had an effect.

after obtaining verbal and written consent from the participants, they are required to answer the questions on the diagnosis form, acute coronary syndrome response index, and multiple quality of life scale. then, preliminary measurements will be made and a 6-minute corridor walking test will be applied. while the control group will be followed up routinely, the training booklet prepared for the intervention group will be explained orally. participants will then be informed that they will be called monthly. they will be told that they can reach these monthly calls and consult the nurse when they need it. after this stage, interviews with patients will begin. the standard way of communication with the participants by the researchers is by telephone, and a total of 6 interviews will be provided, the first of which is in the 1st month after the application of the tests. in each call, all the information in the training booklet will be repeated, additional information will be given in line with the needs and demands of the person, their questions will be answered and the interview will be ended. although it varies according to the individual interviewed, it is predicted that these telephone interviews will last for 30 minutes on average. apart from these standard calls, individuals in need will be able to reach the researcher face-to-face during phone calls, text messages, instant messaging methods or hospital visits, and in this way, the counseling process will continue actively for 6 months. after six months, the final tests will be done.

Eligibility criteria:
inclusion criteria: * 18 years old, diagnosed with acute coronary syndrome and treated with a stent, * treatment preventing communication is not a problem, literate, * there is no obstacle to performing the 6-minute walk test. * who did not accept to participate, were included in the study. exclusion criteria: * \<18 years of age, * mental or cognitive impairment, * diagnosed with spo2 \<80, * peripheral arterial disease, lower extremity amputation, impaired tumor or open wound of lower extremity, and deep vein thrombosis, 6 munites corridor walk test parts of individuals who are contraindicated in making are not included.

Keywords: acute coronary syndrome counseling nursing
effects of structured skills training group in treatment of adhd in adults

Conditions: Attention Deficit Hyperactivity Disorder (ADHD)

Summary: this study aims to examine if structured skills training group therapy for adhd in adults has beneficial effects superior to 'treatment as usual' including medication in a controlled outpatient setting on clinically relevant outcomes including symptoms, functioning and quality of life measures. the trial is designed as a multicenter randomized controlled, parallel group study. patients are randomized into 1 of 2 treatment arms with 14-week duration: one arm with initial intervention by structured skills training groups by weekly sessions or one with control condition (treatment as usual). then after 15 weeks patients in the control condition arm are switched to the active intervention by 14 weeks of structured group therapy. all patients are assessed for defined outcomes after six months.

background: the focus in recent years on evidence for non-pharmacological treatment in adults with adhd raises the question of potential effects of structured group therapy. structured skills training groups have shown beneficial effects in some studies in an outpatient psychiatric context by reduction in adhd symptoms in individuals who remained stable regarding medication status. aims: the main objective for the trial is to investigate the potential effects of structured skills training groups in a clinically relevant but still controlled setting on broader outcomes including both symptomatic, functional and health related quality of life measures. methods/design: the trial is designed as a multicenter randomized controlled parallel group design. at each outpatient site the enrolled patients are randomized into two groups for either group 1 (g1) with start of weekly treatment in active structured skills training group lasting for 14 weeks or allocated to group 2 (g2) with treatment as usual/clinical management and with 15 weeks delayed start of their group treatment for comparison wth patients in the other arm. those patients in the control condition arm receiving treatment as usual or clinical management of individual patients (g2), are thereafter switched to active structured skills training group therapy.all patients are followed up after six months with assessments of primary and secondary outcomes.

Eligibility criteria:
inclusion criteria: * diagnosis of adhd according to the diagnostic and statistical manual of mental disorders, 4th. edition (dsm-iv) persisting in adulthood exclusion criteria: * any psychotic disorder * recently suicidal behaviour * substance or alcohol abuse or dependence within three months prior to screening for inclusion * pervasive developmental disorder * intellectual disability * seizures or any neurological diseases causing mental handicap

Keywords: group therapy structured skills training dialectic behavioural therapy
bright light therapy for depressed geriatric inpatients

Conditions: Unipolar Depression

Summary: bright light therapy has been shown to be effective for the treatment of both seasonal and non-seasonal unipolar depression as well as bipolar depression, primarily in outpatients under the age of 60. there is a dearth of studies exploring the efficacy of this treatment modality among elderly depressed inpatients, which is our study population.

investigators are studying the ability of light therapy to reduce depressive symptoms in elderly patients who are hospitalized with unipolar depression (depression that is not due to bipolar disorder). participants will receive either active light treatment or inactive treatment (also known as placebo).

Eligibility criteria:
inclusion criteria: * a current episode of non-psychotic unipolar depression as the primary reason for psychiatric hospitalization * currently hospitalized on the musc senior care unit * age 60 years or older * hamd-17 ≥8 exclusion criteria: * any prior use of bright light therapy * primary indication for hospitalization is for a disorder other than major depressive disorder (determined by patient's treatment team) * photosensitive medical conditions or current use of photosensitizing medications - if patients have been advised by a treating clinician at any point to avoid sunlight because of their current medication regimen or medical condition, they will be considered to have a photosensitive medical condition and will be excluded from this study. * treatment with ect; if a patient's condition deteriorates during study participation such that the treatment team feels ect would be in their best interest, they will be withdrawn from study participation. for logistical and transport purposes, the study team feels that exclusion of patients receiving ect will be necessarily. additionally, these patients would likely be excluded from a future larger rct given that ect would likely interfere with signal of blt efficacy. * uncontrolled headaches or any migraines within the last month * major neurocognitive disorder * severe intellectual disability * inability to consent for the study * active psychosis * inmates

Keywords: depression geriatrics psychiatry stress disorders
vasostar vibrational guidewire system to facilitate crossing coronary artery chronic total occlusions

Conditions: Chronic Total Occlusion of Coronary Artery; Chronic Angina

Summary: the goal of this project is to provide an improvement in wire performance to expedite crossing difficult lesions in the coronary vasculature.

this early feasibility study (efs) is proposed to evaluate the initial safety and efficacy of the vasostar guidewire system to cross complex coronary vascular lesions in non-tortuous arterial segments which are resistant to crossing with a traditional interventional guidewire.

Eligibility criteria:
inclusion criteria: * male or female, over 18 years of age, presenting with at least one ischemia inducing lesion in a native coronary artery that is refractory to standard guidewire crossing. chronic total occlusion (cto) is defined as 100% coronary blockage for over a 3-month duration documented either by prior catheterization or by clinical evaluation * suitable candidate for non-emergent, coronary angioplasty * documented de-novo or restenotic coronary chronic total occlusion defined as a lesion with timi 0 flow for at least 90 days refractory to conventional guidewire crossing * left ventricle ejection fraction \> 20% within the last 12 months. * for antegrade chronic total occlusion procedures, activated clotting time (act) should be \> 300 sec * chronic total occlusion in a non-tortuous arterial segment * voluntarily sign a patient informed consent form specific to the study. * physically and mentally willing to comply with all study requirements. exclusion criteria: * successful target lesion crossing with a conventional wire system prior to enrollment * prisoners. * pregnancy * patient has an active implantable. * extensive dissection created by refractory guidewire * severe ongoing congestive heart failure (new york heart association class iv symptoms) * active infection * uncontrolled hypertension (systolic blood pressure \> 180 mm) at the time of the procedure * history of severe reaction to contrast media * recent myocardial infarction (within 2 weeks) * in-stent target lesion * severe cerebrovascular disease including history of prior stroke or transient ischemic attack within 1 month at the time of the procedure * saphenous vein graft (svg) chronic total occlusion or an in-stent chronic total occlusion * short life expectancy due to other illnesses such as cancer or pulmonary, hepatic or renal disease * participation in another investigational protocol at the time of the procedure
candida albicans in periodontal and endodontic lesions in diabetic and normoglycemic patients

Conditions: Diabetes

Summary: pulpal and periodontal tissues are closely related and have similar microbiota that cross-contamination between the pulp and periodontal tissues.the aim of this study was to investigate the prevalence of isolated candida albicans from periodontal endodontic lesions in diabetic and normoglycemic patients and their virulence in different atmospheric conditions. a case-control study was conducted on 15 patients with type 2 diabetes mellitus (g1) and 15 non-diabetics (g2), with periodontal endodontic lesions. samples of root canals and periodontal pockets were plated on chromagar for later identification by polymerase chain reaction (pcr) and virulence test.

this case-control study was conducted on thirty patients (15 patients with type 2 diabetes mellitus and 15 normoglycemics) with clinical and radiographic diagnosis of a periodontal endodontic lesion. to assess the glycemic control of the patients were measured the plasma glucose level and glycosylated hemoglobin concentrations (hba1c). all patients were initially submitted to examination to verify the clinical periodontal parameters (plaque index, probing bleeding, probing depth, clinical attachment level and gingival recession) and pulp sensitivity testing. the study included patients who presented periodontal pockets involving the apical region of the tooth and pulp necrosis (periodontal endodontic lesion). exclusion criteria were: use of antibiotics in the last six months, pregnancy, smoking, other systemic diseases, clinical signs of oral candidiasis, and patients who did not sign a free and clarified consent term. sample collection collection from the root canal was performed after access, rubber dam isolation, disinfection of the surgical field with 5.25% sodium hypochlorite, and neutralization with 5% sodium thiosulfato, with 3 sterile paper points remaining in the root canal for one minute. sampling of the periodontal pocket was made at the deepest site through 3 sterile paper points, inserted one by one for one minute. the material collected from the periodontal pocket and the root canal was inoculated in eppendorf tubes containing 1 ml of reduced transport fluid (rtf). next, samples from each site were diluted and plated on the medium saboraund dextrose agar plus chloramphenicol and chromogenic medium (chromagar candida ®, biomerieux, paris, france) and incubated at 37° c for 48h in a reduced oxygen atmosphere (10% co2 and 90% air). the green colonies that grew on chromagar plates were chosen at random and stored in glycerol at 20° c for later identification by pcr.

Eligibility criteria:
inclusion criteria: -patients who presented periodontal pockets involving the apical region of the tooth and pulp necrosis (periodontal endodontic lesion). exclusion criteria: * use of antibiotics in the last six months, * pregnancy, * smoking, * other systemic diseases, * clinical signs of oral candidiasis * patients who did not sign a free and clarified consent term.

Keywords: candida endodontic lesion diabetes
retrospective/prospective analysis of surgical outcomes of robotic prostatectomy at the james

Conditions: Prostate Cancer

Summary: this is a retrospective/prospective analysis of surgical outcomes of robotic prostatectomy.

this retrospective / prospective study will allow us to collect and analyze the presurgical, peri-operative, and outcome data of patients who undergo robotic radical prostatectomy at the arthur g. james cancer hospital and solove research institute, the ohio state university medical center, beginning february 2008 onwards.

Eligibility criteria:
arm a: inclusion criteria: * patients with prostate cancer who have undergone robotic radical prostatectomy at the arthur g. james cancer hospital and solove research institute, the ohio state university medical center. * ability to understand and willingness to sign the written informed consent document. * 18 years and older arm b: inclusion criteria: * patients with prostate cancer that will undergo robotic radical prostatectomy at the arthur g. james cancer hospital and solove research institute, the ohio state university medical center. * ability to understand and willingness to sign the written informed consent document. * 18 years and older

Keywords: prostatectomy surgery prostate cancer
effect of education and respiratory rehabilitation on quality of life in copd patients

Conditions: COPD

Summary: in patients with copd and a history of recent exacerbation, to compare the quality of life after completing a joint program of health education and respiratory rehabilitation with those patients who only receive respiratory rehabilitation. to compare lung function, the distance traveled in the 6-minute walk test and in the test of the shuttle between both groups. also, to compare between both groups adherence to inhaled treatment, physical activity, and emotional condition. finally, to compare the number of visits to emergencies and hospitalizations, and on the other hand, the number of mild, moderate and severe exacerbations between both groups

in this trial we selected copd patients with a history of recent exacerbation to be submitted to a respiratory rehabilitation program with or without a individualized program of health education. we try to demonstrate a better improvement in the quality of life after completing a joint program of health education and respiratory rehabilitation in this patients than those one who only receive respiratory rehabilitation. we also want to demonstrate an improvement in lung function, the distance travelled in the 6-minute walk test and in the test of the shuttle, the adherence to inhaled treatment, the physical activity, the emotional condition, the number of visits to emergencies and hospitalizations and the number of mild, moderate and severe exacerbations between both groups.

Eligibility criteria:
inclusion criteria: * age over 30 years. * copd diagnosis according to gesepoc criteria (fev 1 / fvc greater 0.7). * smoker or ex-smoker with a cumulative consumption of more than 10 packages per year. * exacerbation of copd diagnosed in the last 15 days. exclusion criteria: * impossibility of obtaining informed consent. * osteoarticular, neuromuscular or cognitive limitation. * diagnosis of active neoplastic disease, except epidermoid carcinoma of skin. * patient with limitation or difficulty to go to the rehabilitation unit to complete the training program. * participation in another study / trial in the previous 6 months. * have participated in a respiratory rehabilitation program the previous year (12 previous months).
an access delivery model that eliminates barriers to breast cancer care delivery

Conditions: Breast Cancer

Summary: the purpose of the research is to examine the usefulness of using patient navigators in improving coordination of care between the breast examination center in harlem (bech) and the ralph lauren center for cancer care and prevention (rlcccp) for patients with a suspicious breast finding. this study will collect information to improve the role of the patient navigator, nonmedical staff that helps coordinate patient care. the study will also collect information to be used to help remove barriers that happen when several different institutions provide care.

this purpose of this protocol is to systematically evaluate the role of patient navigators, non-medical personnel who assist in the coordination of care, for women attending a breast cancer screening clinic in harlem who are found to have a suspicious result. the concept of patient navigation, developed by dr. harold freeman, has been identified as a promising strategy to reduce disparities in health care for minorities and the underserved. this protocol will evaluate the role of the patient navigator in coordinating care for women who are referred to the ralph lauren center for cancer care and prevention (rlcccp) from the breast examination center of harlem (bech). to achieve this, we propose four interrelated tasks. first, we will characterize in detail the specific nature of the activities of the navigators as they remedy barriers to the receipt of breast cancer care. secondly, we will determine whether the presence of the navigator minimizes the percentage of patients with significant delays in receipt of necessary care. third, we will measure patient satisfaction with care and their perceptions of the value of the navigator. finally, we will provide a baseline needs assessment of those (eligible) patients requiring pain and palliation services. specific aims: 1. to characterize the role of patient navigators by defining the specific tasks and activities they perform in order to eliminate and/or reduce barriers to receipt of cancer care. 2. to evaluate how the presence of a patient navigator influences the time intervals from receipt of a suspicious screening mammogram or palpable breast mass to appropriate diagnosis and or treatment. 3. to measure patient's satisfaction with the coordination of care in the presence of a patient navigator. 4. to descriptively assess the pain and palliation needs of the population under study.

Eligibility criteria:
inclusion criteria: * women with a suspicious screening finding * referred from breast examination center of harlem (bech) exclusion criteria: * women that were not initially seen at breast examination center of harlem (bech) * women with normal breast screening findings

Keywords: breast