Kornimate/medical-research-clean huggingface dataset:
health benefits of functional meat (with n-3 fatty acids and rosemary extract) on low risk for cardiovascular disease people

Conditions: Low Risk for Cardiovascular Disease

Summary: volunteers were randomly assigned by gender to follow of two 12 weeks experimental periods: intervention (i) and control (c) in different order (i/c or c/i). both periods were separated by a 4 weeks wash-out interval during which subjects returned to their usual diet: during the i period, volunteers weekly consumed three 150g/serving functional meat (fm) products (cooked ham and turkey breast). it was firmly recommended that all other meats and meat derivatives had to be excluded from the diet. during the c period, volunteers consumed identical amounts of meat products that did not include functional ingredients (control meat (cm)). functional meat (fm) products (functional cooked ham (fh) and functional cooked turkey breast (ft)), were manufactured mixing the meats with the patented formula® (p200402755.2004). the amount of supercritical rosemary extract, deodorized salmon oil and vitamin e used was respectively, 0.02% w/w, 0.6% w/w, and 0.001% w/w. control meat (cm) products (control cooked ham (ch) and control cooked turkey (ct), were prepared without addition of the functional ingredients.

the total duration of the study was 28 weeks: first experimental period 0-12 weeks, washout period 12-16 weeks second experimental period 16-28 weeks:

Eligibility criteria:
inclusion criteria: * men and women aged over 18 years * at least 2 lipid profile parameters altered (tag ≥150 mg /dl and/or total cholesterol ≥200 mg / dl and/or ldl ≥130 mg / dl and/or hdl ≥40mg/dl men or ≥ 50mg/dl women). * signed informed consent exclusion criteria: * individuals with body mass index (bmi) ≥ 35 kg/m2 * individuals with diabetes mellitus insulin dependent * individuals with disorders associated with eating behaviour * individuals with consumption of omega 3 functional foods, fish oil or antioxidant supplements * individuals inability to consume the test foods (ej. vegetarians) * individuals with special diet due to disease as celiac disease, chronic renal failure, etc. * individuals with mental disease or low cognitive function. * individuals with consumption of drugs to weight lost. * individuals treated with drugs whose direct effect is on lipid profile (statins, fibrates, diuretics, corticosteroids or oral anti-inflammatory). * individuals with diseases that could be involucrate in weight lost (not controlled hypothyroidism, serious psychiatric illness, etc.). * pregnant women or lactating. * individuals with regular consumption of anti-inflammatory or glucocorticoids.

Keywords: fatty acids, omega-3 rosemary extract functional meat cardiovascular disease
evaluation of the effect of 980nm diode laser intracanal irradiation on levels of interleukin-8 expression

Conditions: Endodontically Treated Teeth

Summary: this clinical trial will be conducted to evaluate the amount of il-8 expression before and after the application of intracanal irradiation with diode laser 980 nm versus placebo in failed endodontic cases with periapical lesions.

* thorough medical and dental history for the eligible patients * thorough intraoral and extraoral diagnosis * local anesthesia * isolation and removal of any previous filling or restoration * removal of old gutta percha and establish patency to the full working length. * 1st sample: will be collected using 3 sterile paper points * chemo-mechanical preparation. * 2nd sample collection • laser group: the canals will be irradiated with a high-power diode laser, with wavelength of 980 nm, maximum output of 3 watts and coupled with a fiber optic tip of 200 µm diameter. • mock laser application (placebo group): the fiberoptic tip will be inserted inside the root canal, mimicking the laser irradiation, but not activated. * 3rd sample collection * a piece of dry cotton will be placed in the access cavity, and then will be sealed with glass ionomer filling material * 2nd visit: 1 week later, 4th sample collection then obturation * number of visits \& follow up period: two visits

Eligibility criteria:
inclusion criteria: * failed previously treated endodontic single-rooted teeth with chronic periapical lesions; with radiographic evidence of periapical radiolucency of not less than 1 cm diameter will be selected. * teeth with straight root canals. * no contributory medical history. * no previous administration of analgesics and/or antibiotics within the previous 2 weeks. exclusion criteria: * retreatment cases with complications such as separated instruments, perforations, ledges, resorption, transportation, calcifications, immature apices and over fillings. * teeth with curved roots. * swelling or sinus tract. * mutilated teeth that interfere with proper isolation and seal between visits. * subjects with generalized periodontitis, or if the tooth has a probing depth of more than 3 mm. * subjects with uncontrolled diabetes or debilitating diseases. * pregnant or nursing females. * systemic disorders that necessitate antibiotic prophylaxis or prevent the use of ibuprofen.

Keywords: diode laser endodontic retreatment il-8 expression
hiv/std safer sex skills groups for women in drug treatment programs - 1

Conditions: Behavior Therapy

Summary: the purpose of this study is to look at a program for women in drug abuse treatment designed to reduce human immunodeficiency virus/sexually transmitted disease (hiv/std) risk behaviors and reduce unprotected sexual risk behavior.

the proposed trial is intended to test the effectiveness of a proven, manual driven, five-session safer sexual skills building group (ssb) intervention (schilling et al., 1991; el bassel and schilling, 1992) for female patients in mmtp or in drug-free outpatient treatment. the effects of ssb will be compared to a standard group hiv education session (he). this study uses a 2-group, randomized, parallel-group design to compare a five-session safer sexual skills building group to a single 60-min hiv education session (control condition). the control condition is designed to standardize and simulate the usual care at community clinics.

Eligibility criteria:
adult females (18 years of age or older) in drug abuse treatment at participating community treatment programs are invited to participate.

Keywords: behavioral intervention
terlipressin infusion during whipple procedure: effect on blood loss and transfusion needs

Conditions: Terlipressin; Blood Loss

Summary: the present study aims to look at the effect of terlipressin infusion on blood loss and blood transfusion needs during whipple procedure


Eligibility criteria:
inclusion criteria: * all patients older than 18 years of age, * asa classification class i and ii, * patients assigned for whipple procedure. exclusion criteria: * preoperative renal failure, * severe liver dysfunction (child-turcotte-pugh grade c), * hyponatremia (na+ \<132mmol/l), * severe valvular heart disease, * heart failure, * symptomatic coronary heart disease, * bradycardic arrhythmia (heart rate \< 60/min), * peripheral artery occlusive disease (clinical stadium ii-iv), * uncontrolled arterial hypertension (blood pressure \>160/100mmhg despite intensive treatment), * pregnancy.
molar incisor malformation in egypt

Conditions: Paediatric Dentistry

Summary: the aim of the current study is to assess the prevalence of molar incisor malformation in fayoum-egypt.

localized developmental radicular dysplasia is a rare finding. this radicular formation arrest may be due to traumas, infections, radiation therapy, chemotherapy, or idiopathic. molar incisor malformation is a condition characterized by arrested or altered radicular development of first permanent molars. roots may be thin, short, or totally missing. in some patients, there are constrictions located in the cervical part of the crown of the permanent incisors. there are also cases where the roots of the second primary molars are affected. mim could also have been mistaken for a consequence of severe root resorption, or dentine dysplasia prior to its initial description. this unique deformity, regardless of its nomenclature, presents previously undescribed clinical features and it is quite difficult to get a successful conservative treatment result. the aim of the current study is to assess the prevalence of this rare condition in fayoum-egypt.

Eligibility criteria:
inclusion criteria: * panoramic radiographs for older than nine-year-old patients, having completely developed first permanent molars exclusion criteria: * panoramic radiographs with missing first permanent molars or pathological lesions which may cause root resorption

Keywords: molar-incisor malformation, developmental malformation
association of herpesvirus and periodontitis

Conditions: Periodontitis

Summary: a significant influence of the herpes viruses family in the progression of periodontal disease has been suggested. the aim of this study was to investigate the potential association of four herpes viruses (hsv-1, hsv-2, cmv and ebv) with periodontal disease using a qualitative test for evaluating the presence or absence of viral dna in crevicular fluid samples of both healthy periodontal patients and periodontal compromised patients. adult patients with healthy periodontium or periodontally compromised attending the egas moniz university dental clinic (almada, portugal) are eligible to participate the study involves a periodontal diagnosis and collection of unstimulated crevicular fluid from saliva samples. there will be no direct benefits for patients, but indirect benefit of advancing science in the study of potential involvment of herpes viruses in periodontitis. no risks of participating are antecipated as the study material and data will be anonymized. the study runs from the the cooperativa de ensino egas moniz and is expected to run for 3 months.


Eligibility criteria:
inclusion criteria: * patients (\> 18 years of age) with natural teeth attending clinical appointments at the egas moniz university dental clinic; * cases (periodontally compromised) included at the department of periodontology of the same clinic; * controls (periodontally healthy) included at the remaining departments of the same clinic. exclusion criteria: * occurrence of a viral infection during the six months prior to the clinical study; * exposure to antiviral medication in the six months prior to the survey; * clinical history of immunosuppression, either exogenous or endogenous; * chemotherapy in the previous six months.

Keywords: periodontitis herpes virus
an observational study of tocilizumab (actemra) in participants with moderate to severe rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this observational study evaluates the use and efficacy of intravenous (iv) tocilizumab in routine clinical practice in participants with moderate to severe rheumatoid arthritis. eligible participants initiated on tocilizumab treatment in accordance with the local label were followed for 6 months.


Eligibility criteria:
inclusion criteria: * adults, \>/= 18 years of age * moderate to severe rheumatoid arthritis according to the revised (1987) american college of rheumatology (acr) criteria * participants in whom the treating physician has made the decision to commence tocilizumab treatment (in accordance with the local label); this can include participants who have received tocilizumab treatment within 8 weeks prior to the enrollment visit exclusion criteria: * participants who have received tocilizumab more than 8 weeks prior to the enrollment visit * participants who have received treatment with any investigational agent within 4 weeks (or 5 half-lives of the investigational agent, whichever is longer) before starting treatment with tocilizumab * history of autoimmune disease or any joint inflammatory disease other than rheumatoid arthritis
assessment of physician consideration of epro's, from patients with gout, rheumatoid arthritis, sjogren's syndrome or systemic lupus, on the frequency of therapeutic adjustments

Conditions: Gout; Rheumatoid Arthritis; Sjogren's Syndrome; Systemic Lupus Erythematosus

Summary: inflammatory rheumatic diseases affect 1% of the population. treatment of such diseases should be based on disease activity, safety issues and other patient characteristics such as comorbidities (eular, 2022), leading to a higher risk of cardiovascular diseases. to this end, the general treat-to-target approach, as recommended in the eular guidance, may require several successive treatment lines based on updates to the patients' profile and close monitoring as the keystone of its implementation. regular feedback from patients could be used to fuel such strategies. this feedback can be collected using an epro (electronic patient reported outcome). the purpose of this study is therefore to assess patient management using the information provided by patients through e-pros, which will transfer the data provided by the patient to the physician and will notify the investigators via email when a patient has completed a form (no data interpretation or alerts). the hypothesis is that the more physicians are provided with insights into their patients' health, the more they will function in a treat-to-target approach and the more often they will tend to adjust their patients' treatments.


Eligibility criteria:
inclusion criteria: * men or women of at least 18 years of age * diagnosed with (at least) one of the following autoimmune diseases: * rheumatoid arthritis (ra) according to the 2010 eular/acr classification criteria, * gout according to the 2015 eular/acr classification criteria, * systemic lupus erythematosus according to the 2019 eular/acr classification criteria * sjogren's syndrome according to the 2016 eular/acr classification criteria * according to local regulations, patient has expressed his/her non-opposition (for france) or has provided written informed consent (for switzerland and germany) to participate in the study * patient has access to the internet, a functioning email address and a mobile phone number * patient physically and mentally able to use a computer tool connected to the internet * only in switzerland \& germany : patient is covered by a health insurance plan exclusion criteria: * any neurodegenerative disease that alters cognitive faculties * refractory cancer * patients who do not have access to the internet and/or do not master its use in the context of this protocol * unwillingness or inability to adhere to study protocol (language barriers, cognitive disorders...) subject who is compulsorily detained for psychiatric treatment * patient who cannot be followed for 2 years by the investigating physician * patient over the age of legal majority who is protected, or deprived of liberty by judicial or administrative decision (vulnerable subject) * patient with an estimated life expectancy shorter than 1 year
the effect of glp-1 on glucose uptake in the brain and heart in healthy men during hypoglycemia

Conditions: Type 2 Diabetes; Stroke; Myocardial Infarction

Summary: type 2 diabetes mellitus, t2d is a disease characterized by an immense growing prevalence world wide with an increased risk of myocardial infarction and stroke. glp-1 has convincing effects on the high glucose levels in type 2 diabetic patients and is well tolerated. new animal studies indicate a protective effect of glp-1 in the brain and the heart. the mechanism behind this is yet not known. the study hypothesis is that during hypoglycaemia glp-1 will stimulate glucose-uptake in the brain and heart independent of insulin and thereby exert protective effects in the brain.

type 2 diabetes mellitus, t2d is a disease characterized by an immense growing prevalence world wide. t2d is associated with a three-fold increase in cardiovascular complications (myocardial infarction and stroke) leading to significantly higher morbidity and mortality in this group of patients. the prospective british diabetes study (ukpds) showed that neither diet alone nor the pharmaceutical treatment utilized (sulphonylurea, metformin, insulin) were able to reduce these macrovascular complications. glp-1 (glucagon-like-peptide-1)is an incretin with convincing effects on glycaemia in type 2 diabetic patients with little or no risk of hypoglycaemia. new research in animal models has shown a potential protective effect in the brain and heart in association with ischaemic damage. the mechanism behind this protective effect is not known. during hypoglycaemia the brain lacks glucose which is the main fuel for sufficient brain function. the brain will compensate by increasing glucose uptake across the blood brain barrier and similarly in the heart. the effect of native glp-1 on glucose uptake in the brain and heart will by visualized by fluoro-deoxy-glucose fdg-pet-scan during hypoglycaemia in healthy men. at the same time a pancreatic/pituitary clamp will be performed. the hypothesis is that glp-1 directly will stimulate glucose uptake independent of the pancreatic hormones and through this mechanism exert neuro- and cardioprotective actions. comparisons: fdg-uptake in the brain and heart with glp-1 infusion compared to placebo.

Eligibility criteria:
inclusion criteria: * healthy men * age 20-50 years * caucasian * bmi 20-30 kg/m2 exclusion criteria: * diabetes in subject and 1.degree relatives * any disease of clinical relevance

Keywords: glp-1 glucose metabolism type 2 diabetes brain pet
assessment of a new closed-loop algorithm in type 1 diabetes (saddle point model predictive control : sp-mpc) (ppa)

Conditions: Type 1 Diabetes

Summary: the purpose of the study is to assess a new closed-loop algorithm in type 1 diabetes (saddle point model predictive control : sp-mpc)

ten patients will be assessed during a closed-loop night and an open-loop night in random order. the primary objective is to assess the ability of sp-mpc controler to maintain euglycemia and avoid hypoglycaemia during the night, compared to open loop in type 1 diabetic patients treated by insulin pump.

Eligibility criteria:
inclusion criteria: * patients with type 1 diabetes (c peptide negative) : * 18 to 70 year old, * with type 1 diabetes for more than 3 years, * treated by insulin pump for more than 3 months, * with previous cgm holter allowing preliminary settting of some of the sp-mpc parameters * able to provide written informed consent. exclusion criteria: * pregnancy or breastfeeding, * severe non stabilized diabetic retinopathy, * cardiovascular event in the previous 6 months, * infectious diseases with recent fever, * anemia (hemoglobin \< 11g/l), * hba1c \> 10%, * current or recent (less than 4 weeks) oral or injectable corticosteroid treatment, * creatinine clearance \<40ml/mn, * chronic alcoholism (weekly consumption of alcohol \> 280g for men and \> 140g for women), * adults legally protected (under judicial protection, guardianship, or supervision), persons deprived of their liberty

Keywords: artificial pancreas, closed loop glucose control, model predictive control
integrated dose escalation for advanced, localized gynecologic cancer (the ideal - gyn trial)

Conditions: Cancer of the Cervix; Cervical Neoplasms

Summary: the purpose of this study is to determine the maximum tolerated dose of integrated boost radiation therapy when given with concurrent chemotherapy (cisplatin).


Eligibility criteria:
inclusion criteria: * biopsy confirmed malignancy of the gynecologic tract * involved pelvic or para-aortic lymph nodes * treatment plan to include delivery of concurrent chemoradiotherapy. * good performance status * negative pregnancy test in women of child-bearing potential * signed study-specific informed consent * lab results within study specific limits exclusion criteria: * prior radiation to the abdomen or pelvis * a history of scleroderma or inflammatory bowel disease * contraindication to chemotherapy or radiation
clinical value of left colic artery in laparoscopic radical rectectomy

Conditions: Overall Survival; Postoperative Complications

Summary: colorectal cancer is one of the most common tumors in asia. according to the recent research, surgical procedure could provide more treatment benefit in rectal cancer. therefore, it was consider that important to standardized and improved the surgical procedure for rectal cancer. with the development of anatomical technique, minimally surgery with laparoscopy had become the trend for surgical treatment. there were several studies has been done to evaluate the safety and feasibility of laparoscopic surgery. in order to achieve better surgical outcome and reduce operative complications, the investigators design stratified randomization, double blinded, muti - center clinical trail to investigate the value of left colic artery in laparoscopic radical rectectomy.


Eligibility criteria:
inclusion criteria: * aged more then 18 years old; * diagnosed as rectal cancer with colonoscopic biopsy; * without metastasis; * no invasion of surrounding tissues; * limited operation; * underwent laparoscopic radical proctectomy(l-dixon); * bmi 18\~30kg/m2; * without multiple primary tumors; * sign on the medical informed consent. exclusion criteria: * simultaneous or simultaneous multiple primary colorectal cancer; * preoperative imaging examination results show: (1) tumor involves the surrounding organs and combined organ resection need to be done; (2)distant metastasis; (3)unable to perform r0 resection; * history of any other malignant tumor in recent 5 years; * patients need emergency operation; * not suitable for laparoscopic surgery; * women during pregnancy or breast feeding period; * informed consent refusal

Keywords: left colic artery laparoscopic surgery anterior resection of rectum rectum cancer
working memory training for chronic neuropathic and fibromyalgia pain

Conditions: Working Memory Deficits; Neuropathic Pain; Fibromyalgia

Summary: the goal of this project is to investigate and improve executive control function in two distinct pain conditions, namely neuropathic pain and fibromyalgia (fm). it is hypothesized that there is a significant difference in the executive control function of patients with neuropathic pain and fm pain. it is also hypothesized that all participants with poor executive control functioning will report significant improvements in pain intensity, functioning and cognitive complaints following cognitive training. the study tests and influence the working memory concepts of inhibition, updating and flexibility through an experimental, cross-over treatment design. to perform the experiment, we will recruit 160 participants (80 with neuropathic pain and 80 with fm) from the departments of pain management and research at st olav's university hospital and oslo university hospital (ous). the proposed design will be able to determine whether or not executive control, processing speed and memory function differs in two distinct populations of pain patients. moreover, whether impairments are amended by computerized training.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of fibromyalgia or neuropathic pain * confirmed objective cognitive impairments on the cantab battery compared to iq control exclusion criteria: * mania, suicidal ideation and/or active psychosis * no objective cognitive impairments * personality disorders * pregnancy

Keywords: pain working memory