Kornimate/medical-research-clean huggingface dataset:
automatic oxygen administration during the respiratory distress in infants and children (infant-freeo2)

Conditions: Hypoxemic Acute Respiratory Distress; Infant Between 1 Month and 24 Months Old; Child Between 2 and 15 Years Old

Summary: the aim of the study is to assess the use feasibility of the freeo2 system so as to deliver automatically oxygen in infants and children admitted at hospital for hypoxemic acute respiratory distress. in healthy volunteers adults, freeo2 system provided a better control of the oxygen saturation in function of designed target, reducing the desaturation time and hyperoxia. our hypothesis is that freeo2 system use is feasible in infants and children with hypoxemic acute respiratory distress. we think freeo2 will provide a better control of the oxygen saturation, a faster oxygen weaning than classical way (rotameter). in addition, freeo2 could reduce the number of intervention by nurses.


Eligibility criteria:
inclusion criteria: * admission to the emergency for respiratory disease justifying an oxygen administration to maintain a spo2 ≥ 92%. * inclusion within a time less than 24 hours after the start of the oxygen at the emergency department. * written consent of the parents of the child exclusion criteria: * necessity of an oxygen flow exceeds 4 l / min to maintain a spo2 higher than 92% * criteria of gravity justifying immediately a different technique of ventilatory support: * disturbance of consciousness with a glasgow coma score ≤ 12 * hemodynamic instability (mbp \< - 2 ds or need for vasopressors) * cardiac or respiratory arrest * ph \ 55 mm hg * necessity of a urgent surgery * age \< 1 month * respiratory rate \> 80 b/min (1 month-2 years old), \> 40 b/min (2 - 10 years old) \> 30b/min (\> 10 years old) ou \< 10 b/min

Keywords: hypoxemic, respiratory distress, infant
pilot study on the effects of low-level laser therapy treatment for acute and persistent discomfort

Conditions: Chronic Pain; Acute Pain

Summary: this study will examine the effectiveness of low-level laser therapy (lllt) for the management of pain in various locations of the body. all subjects selected for participation in the study will be assigned to a lllt treatment group for a duration of 12 sessions.

low-level laser therapy (lllt) is a treatment modality that is gaining popularity in the field of physical therapy for its proposed mediation of pain. lllt is typically used in conjunction with other more conventional physical therapy treatment sessions; therefore, it is not clear if the benefits are from the lllt or the conventional treatment, or the combination of them both. the research question: does low-level laser therapy treatment with a class 3b laser decrease pain and improve function in persons with persistent or acute joint/muscle discomfort as compared to before treatment? study participants presenting with pain will be interviewed regarding the location and intensity of their primary pain complaints. participants will also be asked to identify functional limitations associated with their pain. participants will undergo an initial screening process to identify the presence of any exclusion factors and precautions associated with the delivery of lllt. investigators will collect pre-test and post-test information from participants regarding pain intensity and perceived functional limitations. investigators will also collect relevant joint range of motion and muscle strength data during the first and last sessions. treatment location for the study will vary within the participant group and will be determined during the initial screening process. the intervention will include lllt treatment using a combination of led and laser light delivered by the richmar theratouch lx2 device.

Eligibility criteria:
inclusion criteria: * subjects having persistent or acute discomfort/pain in a muscle or joint of their body * ability to speak english or provide own translator * ability to complete the pre-test/post-test session * ability to attend three times per week exclusion criteria: * pregnant women * currently undergoing immunosuppression therapy * subjects with photosensitivity concerns
pegasys long-term anti-fibrotic effect co-infection trial (perfect)

Conditions: HIV/HCV Coinfection

Summary: this is an uncontrolled, open-label, phase iii trial of peginterferon alfa-2a (pegasys) in participants coinfected with human immunodeficiency virus (hiv) and hepatitis c virus (hcv). participants with hiv/hcv who do not show negative or reduced hcv ribonucleic acid (rna) after at least 12 weeks of treatment with peginterferon alfa-2a plus ribavirin will receive a low dose of peginterferon alfa-2a for 18 months. the primary objective is to evaluate safety and tolerability. secondary objectives are to evaluate histological, virological, and biochemical effects.


Eligibility criteria:
inclusion criteria: * serologic evidence of chronic hepatitis c infection by anti-hcv antibody test * received peginterferon alfa-2a for at least 12 weeks and either did not reach a 2-log drop in hcv rna after 12 weeks of treatment, did not reach an undetectable hcv rna after 24 weeks of treatment, or reached undetectable hcv rna that was detectable again at the end of 48 weeks of treatment * detectable serum hcv rna at screening * serologic evidence of hiv infection by hiv rna detection * cd4 cell count greater than or equal to (\>/=) 100 cells/mcl during therapy with peginterferon alfa-2a plus ribavirin for at least 12 weeks * stable hiv status and, if on antiretroviral therapy, a stable regimen for at least 6 weeks prior to baseline * compensated liver disease * no evidence of hepatocellular carcinoma exclusion criteria: * pregnant or breastfeeding * antineoplastic or immunomodulatory treatment within 6 months prior to first dose * any investigational drug within 6 weeks prior to first dose * positive for hepatitis a immunoglobulin m antibody * severe neutropenia or thrombocytopenia at screening while still on therapy with peginterferon alfa-2a plus ribavirin * severe psychiatric or neurologic comorbidity * history of any significant medical conditions, such as immune disorders or disease of the major organ systems * uncontrolled thyroid disease * severe retinopathy * evidence of drug abuse
web-based support for people with schizophrenia and their families

Conditions: Relapse Rates Related to Website Usage

Summary: this study will assess the feasibility of using the internet and in-home computers to provide advice from health care professionals, social support, and health information to people with schizophrenia and their families.

the objective of this study is to assess the feasibility of using the world wide web (web) and in-home computers to provide patients suffering from schizophrenia and their families advice from health care professionals, social support, and information. the purposes of this intervention are to improve: 1) the availability, convenience and use of needed mental health services; 2) family support for their ill family members; and 3) patient and family outcomes.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia able to speak and read english regular contact with a family member exclusion criteria: * enrolled in another study

Keywords: schizophrenia relapse psychological distress
chemical dependency and smoking cessation: patient's views - 1

Conditions: Tobacco Use Disorder

Summary: the purpose of this study is to asses patient views on smoking cessation and tobacco harm reduction during drug treatment.

participants included 34 patients who had never voluntarily quit smoking for longer than 24 hours (continuous smokers), 34 smokers who had quit smoking for at least 24 hours before but had relapsed (relapsers), and 10 former smokers who had been abstinent for at least the past 6 months (successful quitters). we held 7 focus groups, 3 with continuous smokers and 4 with relapsers. focus groups lasted 2 hours and were held at participants' clinics to preserve confidentiality. we conducted hour-long individual interviews with successful quitters. all participants completed a brief written survey immediately before their session. survey items included questions on demographics, smoking behaviors, and motivation for cessation, reduction, and nicotine maintenance. we reimbursed all participants $40 and provided a meal to focus group attendees.

Eligibility criteria:
inclusion criteria: selection criteria included being 18 years or older, smoking 5 or more cigarettes per day for at least 2 years, and being enrolled continuously in methadone maintenance treatment (mmt) for at least the past 2 years. exclusion criteria: being less than 18 years of age, smoking 4 or fewer cigarettes per day, smoking less than daily for less than 2 years, and not being enrolled continuously in methadone treatment for at least the 2 past years.
peri-operative ratg-perfusion of solid transplants

Conditions: Organ Preservation Solutions

Summary: the increasing demand for organ transplantation and the shortage of available organs limit the success of organ transplantation programs. consequently, acceptance of expanded criteria donor (ecd) organs with the consequences of higher risk of unfavorable transplantation outcome has become an increasing reality. among the most prominent characteristics distinguishing ecd from standard criteria donors (scd) are risk factors including brain death (bd) or prolonged cold ischemia time (ci) amplifying ischemia reperfusion injury (iri). currently there are no standard regimens to improve the quality of ecd organs. therefore, donor organ treatment might be a promising approach to substantially improve organ quality. it will be investigated whether the application of the peri-operative perfusion of kidneys and livers with the polyclonal antibody rabbit antithymocyte globulin (ratg) ameliorates iri. this trial is designed as a parallel armed randomized controlled trial.


Eligibility criteria:
inclusion criteria: * patients receiving a kidney or liver transplant from deceased donors exclusion criteria: * hepatitis c virus/human immunodeficiency virus, undergoing re-transplantation or under a public guardian
the effect of crt on the hypercapnic ventilatory response

Conditions: Sleep Disordered Breathing; Heart Failure

Summary: central sleep apnoea (csa) affects up to half of patients with severe heart failure and is associated with a poor prognosis. csa is manifest as episodes of deep breathing interspersed with very shallow or absent breathing and is largely due to an exaggerated response to rising carbon dioxide in the blood, which normally drives how hard we breathe. cardiac resynchronization therapy (crt), in which a pacemaker is implanted to improve co-ordinated contraction of the heart, has been shown to reduce the severity of csa in some patient groups. we aim to determine whether this improvement is due to normalization of the body's response to carbon dioxide in the blood. our hypothesis is that crt improves csa by normalizing the brain's response to carbon dioxide.

sleep disordered breathing is common in heart failure, affecting around half of patients. this may be obstructive sleep apnoea due to loss of pharyngeal muscle tone (osa, associated with obesity and snoring and predisposing to hypertension, heart attack and stroke) or central sleep apnoea (csa). csa is particularly prevalent in severe heart failure and associated with an adverse prognosis. the mechanism involves reflex hyperventilation due to pulmonary oedema, exaggerated chemosensor response to hypercapnoea associated with increased sympathetic nervous system activation and a prolonged circulation time. it is known that crt improved csa in 'responders' but the mechanism is unknown. we hypothesis that crt normalizes the respiratory response to carbon dioxide (the hypercapnic ventilatory response - hcvr). we will screen patients undergoing crt with an embletta sleep study to identify a group with moderate to severe csa and a group with no sleep apnoea (controls). patients will undergo assessment of the hypercapnic ventilatory response with a read re-breathe test prior to device implantation and 6 weeks and 6 months afterwards. the gradient of minute ventilation vs paco2 will be compared.

Eligibility criteria:
inclusion criteria: * heart failure with reduced ejection fraction (\<40%) * either no significant sleep disordered breathing or moderate to severe csa * able to consent to the study * ambulatory * aged 18-100 years exclusion criteria: * patients on non-invasive ventilation * predominant osa * unable to consent or attend for the study

Keywords: cardiac resynchronization therapy central sleep apnoea sleep disordered breathing heart failure hypercapnic ventilatory response
routine activity and preterm delivery risk in women with a short cervix

Conditions: Cervical Shortening

Summary: the goal of this clinical trial is to evaluate the effect of routine activity versus rest on the risk of preterm delivery in pregnant women with a short cervix diagnosed between 24 and 34 weeks of gestation. the main questions it aims to answer are: does routine activity influence the gestational age at delivery? how does routine activity affect secondary outcomes such as preterm labor, premature rupture of membranes, delivery mode, maternal anxiety, and satisfaction? researchers will compare women instructed to maintain routine activity (control group) to women advised to practice maximal rest (intervention group) to see if physical activity impacts preterm birth outcomes. participants will: wear a smart band to monitor step counts over a two-week period. be randomized into two groups: one encouraged to maintain routine activity and the other advised to follow strict rest protocols. undergo regular follow-ups at a high-risk pregnancy clinic and have their data collected through hospital records and smart band tracking. this randomized controlled trial will assess gestational age at delivery as the primary outcome, along with secondary maternal and neonatal outcomes, providing insight into the role of physical activity in managing pregnancies complicated by a short cervix.


Eligibility criteria:
inclusion criteria: * singleton pregnancies between 24+0 and 34+6 weeks. * short cervical length (\<25 mm) confirmed via transvaginal ultrasound. * no medical contraindications to physical activity. exclusion criteria: * twin pregnancies or higher-order multiples. * medical indications for reduced mobility (e.g., symphysiolysis, fall risk). * maternal comorbidities, fetal distress, vaginal bleeding, pprom, or need for immediate delivery.

Keywords: preterm delivery physical activity cervical shortening bed rest cervical length high-risk pregnancy randomized controlled trial
western equine encephalitis vaccine, inactivated

Conditions: Virus

Summary: this study is designed to determine the safety and immunogenicity of wee vaccine lot number 3-1-92.

study objectives: primary: to assess safety of the western equine encephalitis (wee) vaccine, inactivated, tsi-gsd 210, lot 3-1-92. secondary: to evaluate immunogenicity of the western equine encephalitis (wee) vaccine, inactivated, tsi-gsd 210, lot 3-1-92.

Eligibility criteria:
inclusion criteria: * 18-55 years of age * in good health as determined by pertinent medical history, brief physical exam, vital signs, and clinical safety laboratory evaluations * female: has a negative urine pregnancy test and is willing to use reliable form of contraception for the study duration * negative hiv antibody screen, seronegative for hbsag and hepatitis c antibody * wee, eee, vee, and chik prnt80\<1:10 * ability to comprehend abnd a willingness to sign an informed consent, which includes the hipaa and a separate hiv consent form * be willing to comply with all follow-up visits, testing, and ae reporting exclusion criteria: * participant in the usamriid sip * receipt of any other vaccine or investigational; drug within 30 days prior to study entry * anticipates receipt of other vaccines for the duration of the study (influenza vaccination will be permitted but not within 28 days of wee vaccination * acute of chronic medical conditions, medications, or dietary supplements that, in the pi's opinion, would impair the subject's ability to respond to vaccination * hypersensitivity to any vaccine * allergic to any vaccine component: human serum albumin, neomycin * receipt of or anticipates receipt of blood products during the study * female: pregnant or breastfeeding * clinically significant abnormal laboratory tests (generally greater than or equl to 2 times the upper limit of normal as determined by the pi)
reliability of a new balance assessment system in patients with adolescent idiopathic scoliosis

Conditions: Scoliosis; Adolescence

Summary: postural stability is one of the most important factors that determine a person's ability to make and maintain movements. it has been reported that in the presence of scoliosis, the postural stability of people is negatively affected due to somatosensory disorders. there are many studies in the literature that evaluate the postural stability of cases diagnosed with scoliosis with objective methods. evaluation of postural oscillations with objective devices is used to determine whether postural stability changes in ais and whether the type and location of scoliosis affect the progression. the most commonly used objective devices for this purpose are balanced assessment systems in which changes in postural sway are recorded on the force platform. our study aims to investigate the reliability of the "postural stability", "limits of stability", "sensory integration" and "bilateral comparison" tests of the al balance balance exercise and analysis system in cases with adolescent idiopathic scoliosis. after the demographic information of the cases that meet the inclusion criteria within the scope of the study is recorded, postural stability and balance evaluations within the al balance system will be performed on the cases. evaluations will be carried out with bare feet and feet positioned at the same coordinates. the tests will last 30 seconds and the test will be repeated a total of 3 times with a 1-minute rest between tests. these measurements will be repeated after 7 days to evaluate reliability. with this study, the reliability of a new and local balance assessment system will be tested in cases with ais.


Eligibility criteria:
inclusion criteria: * being between the ages of 12 and 18 * having been diagnosed with adolescent idiopathic scoliosis by an orthopedic specialist * cobb angle measured on anteroposterior radiograph is below 40 degrees * ability to understand and follow instructions * volunteering to participate in the study exclusion criteria: * presence of neuromuscular, rheumatic disease, or vestibular problems that may affect balance, vision-related diseases * having a recent history of orthopedic injury or surgery in the lower extremity * having had spine surgery * not having experienced any acute situation that could affect postural stability and balance between the two tests (within 7 days) * corset use has not changed between two tests (within 7 days)

Keywords: scoliosis postural control balance reliability
measures for the prevention of surgical site infection

Conditions: Infection

Summary: among the causes associated with infection of hospitalized patients, surgical site infection is a complication that is potentially associated with any type of surgical procedure, it also represents an expressive burden in terms of morbidity and mortality, as well as additional costs for health care systems around the world. it is regarded that the efficiency of the pre, per, and postoperative skin preparation depends on both the adopted antiseptic and the application method, with chlorhexidine currently being the most used drug in such preparation. however, the manner, timing, or timing of cutaneous antisepsis action is unclear. objective: comparing antisepsis techniques using chlorhexidine-based soap associated with ethyl alcohol and alcoholic chlorhexidine versus chlorhexidine-based soap associated with alcoholic chlorhexidine, in surgical orthopedic procedures.

among the causes associated with infection of hospitalized patients, surgical site infection is a complication that is potentially associated with any type of surgical procedure, it also represents an expressive burden in terms of morbidity and mortality, as well as additional costs for health care systems around the world. it is regarded that the efficiency of the pre, per, and postoperative skin preparation depends on both the adopted antiseptic and the application method, with chlorhexidine currently being the most used drug in such preparation. however, the manner, timing, or timing of cutaneous antisepsis action is unclear. objective: comparing antisepsis techniques using chlorhexidine-based soap associated with ethyl alcohol and alcoholic chlorhexidine versus chlorhexidine-based soap associated with alcoholic chlorhexidine, in surgical orthopedic procedures. methods: it is a primary, randomized, analytical and single-center clinical trial, consisting of 170 patients, which were distributed between 2 randomized groups, where chlorhexidine-based soap + alcoholic chlorhexidine were tested on the group csac and chlorhexidine-based soap + 70% ethyl alcohol + alcoholic chlorhexidine were tested on the group csaac. cultures were performed in the mannitol and emb (eosin methylene blue) media after being collected at the pre, post-skin preparation and end of the surgical procedure

Eligibility criteria:
inclusion criteria: * patients both males and females; older than 18 years old who will undergo orthopaedic surgical procedures; exclusion criteria: * patients who do not follow the medical guidelines; that are non-collaborative and / or do not sign the terms of consent.

Keywords: chlorhexidine infection orthopedics surgical rooms antisepsis surgical procedures.