Kornimate/medical-research-clean huggingface dataset:
xiyanping injection combined with azithromycin vs azithromycin for children with pneumoniaprotozoal pneumonia

Conditions: Mycoplasma Pneumoniae Pneumonia

Summary: mycoplasma pneumoniae pneumonia in children is one of the major diseases in children's respiratory department in china, but there are still large clinical unmet needs.

in order to further verify the clinical value and safety of xiyanping injection in children with mycoplasma pneumoniae pneumonia, to provide references for subsequent confirmatory research, and to provide more reasonable and standardized application guidance and basis for clinical practice, we intend to adopt more rigorous scientific design to carry out a multi-center, randomized, double-blind, parallel-controlled study of xiyanping injection in the treatment of children with mycoplasma pneumoniae pneumonia.

Eligibility criteria:
inclusion criteria: 1. 5 to 14 years of age at the time of screening; 2. children who meet the western medicine clinical diagnosis standard of mycoplasma pneumoniae and the mycoplasma pneumoniae igm antibody titer ≥1 : 80, or mycoplasma pneumoniae dna or rna (pcr) test positive, or rapid identification of mycoplasma pneumoniae antibodies positive; 3. heat course ≤ 5 days; 4. the total number of peripheral blood routine leukocytes is within the normal range; 5. the child's legal guardian or / and himself voluntarily participate in the study, and the legal guardian agrees and signs the informed consent form (while children ≥8 years of age need to voluntarily sign the informed consent form); 6. according to the researcher's judgment, the subject / legal guardian is believed to be reliable and able to comply with this plan, visit plan and medication arrangement. exclusion criteria: 1. have a disease that needs to be distinguished from mycoplasma pneumoniae pneumonia (mpp); 2. patients with basic diseases such as primary immunodeficiency disease, acquired immunodeficiency syndrome, congenital respiratory malformation, abnormal lung development, aspiration pneumonia, lung malignancies, etc .; 3. congenital abnormalities of heart and lung, combined with serious primary diseases such as cardiovascular, cerebrovascular, liver, kidney, and hematopoietic system, or any laboratory test indicators meet the following criteria: alanine aminotransferase (alt), aspart amino acid aminotransferase (ast)\> 2.0 times, serum creatinine (cr)\> 1.5 times the upper limit of normal value (uln); 4. those who have been diagnosed with mycoplasma pneumoniae in the past 3 months;
changes in the diameter of retinal vessels after remote ischemic conditioning in patients with type 1 diabetes

Conditions: Retinal Ischemia; Diabetes Complications; Ischemia; Diabetes Mellitus, Type 1

Summary: remote ischemic conditioning (ric) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury. it remains unknown whether this can be used in retinal ischemic diseases. the purpose of the present study is to examine if the autoregulation of retinal vessel diameters in diabetic patients change after remote ischemic conditioning and if the observations are different from what have been observed in normal persons.


Eligibility criteria:
inclusion criteria: * diabetes type 1 * diabetic retinopathy exclusion criteria: * previous treatment for diabetic retinopathy * other ocular and systemic diseases requiring treatment * pregnancy or lactation
the long term clinical course of postinfectious irritable bowel syndrome after shigellosis; a 10 year follow up study

Conditions: Shigella Sonnei Infection

Summary: background: the incidence of postinfectious irritable bowel syndrome (pi-ibs) was reported to be in the range of 5-30%, but limited number of long-term follow-up results. objective: to investigate the long term clinical course of pi-ibs after shigellosis. setting: a shigellosis outbreak in a tertiary referral hospital with about 2,000 employees in korea at 2001. patients: a shigella-exposed cohort of 124 hospital employees who had been infected by shigella sonnei due to contaminated food in the employee-cafeteria in gangnam severance hospital, seoul, korea, at december 2001. a control cohort of age and sex-matched, non-infected 105 contemporary hospital employees. measurements: questionnaire survey for bowel symptoms at 1, 3, 5, 8 and 10 years after outbreak.

postinfectious-ibs (pi-ibs) can be defined as the acute onset of new ibs symptoms in an individual, who has not previously met the criteria for ibs, immediately following an acute illness characterized by 2 or more of the following: fever, vomiting, diarrhea, or a positive bacterial stool culture. our group previously have reported clinical course of pi-ibs in a homogenous cohort which was comprised of patients recovered from shigellosis. and in current study, we finally report a collective result of 10-year long-term follow-up of our small, but well-followed, homogenous cohort of pi-ibs after shigellosis.

Eligibility criteria:
inclusion criteria: * shigella sonnei infected patients exclusion criteria: * refused to participate in these surveys * pregnant or had history of abdominal surgery or chronic organic gastrointestinal disorder
evaluation of portal venous system thrombosis after blunt splenic trauma utilizing doppler ultrasound

Conditions: Thrombosis of Portal Venous System.

Summary: the true incidence of thrombosis in the portal venous system after blunt splenic trauma is unknown and has not been elucidated in the medical literature. the investigators hypothesize that this entity is more common than previously suspected. consequences of missing this diagnosis can be clinically significant, i.e. mesenteric ischemia in the acute phase and portal venous hypertension in the chronic phase. early diagnosis would facilitate treatment with anticoagulation and avoidance of these complications. in a prospective fashion, doppler ultrasound will be performed prior to discharge and at 3 months in all patients 18 and up who have sustained blunt splenic trauma. clinical follow-up will be extended to 6 months in patients initially diagnosed with thrombosis in the portal venous system on their 3 month ultrasound. the investigators will attempt to identify risk factors in this trauma population that would facilitate an early screening protocol.


Eligibility criteria:
inclusion criteria: * all trauma patients 18 and up admitted to rambam medical center with diagnosis of blunt splenic trauma. exclusion criteria: * trauma patients younger than 18.
sexual dysfunction in patients with relapsing remitting multiple sclerosis and associated comorbidities

Conditions: Multiple Sclerosis; Sexual Dysfunction

Summary: this work aims to: 1. investigate and correlate sexual dysfunction in relapsing-remitting multiple sclerosis patients with specific focus on 1. specific neurologic deficit. 2. depressive symptoms. 3. comorbid factors. 4. fatigue symptoms. 2. to investigate the impact of sexual dysfunction on sexual quality of life (sqol). 3. to search for possible gender difference.

the present study is a cross sectional study on 120 ms adolescent patients meeting the mcdonald's criteria; 60 male cases and 60 female cases recruited from mansoura university hospitals, egypt. all patients were subjected to the following: 1. clinical evaluation: 1. thorough neurological examination. 2. cognitive functions by minimental state examination (mmse). e. expanded disability severity scale (edss). 2. neurophysiological evaluation: a. visual evoked potential (vep). 3. imaging evaluation: a. conventional mri. 4. cerebrospinal fluid (csf): 5. sexual dysfunction measure: through the international index of erectile function (iief), female sexual function questionnaire (sfq) and the sexual quality of life male and female version (sqol) (american psychiatric association, 1994). 6. depressive symptoms assessment through the bdi (the beck depression inventory) which is the most common instrument measuring the severity of depression. 7. fatigue symptoms were evaluated through fatigue subscale of multiple sclerosis quality of life-54(msqol-54).

Eligibility criteria:
inclusion criteria: * 120 ms adolescent patients meeting the mcdonald's criteria; 60 male cases and 60 female cases recruited from mansoura university hospitals exclusion criteria: the exclusion criteria: * active relapse or relapse during 30 day prior to survey due to significant changes in all life activities during this period including sexuality. * edss score equal or higher than 6.5. * current pregnancy in female patients. * form of the disease other than rrms. * patients with any sort of cognitive impairment preventing them from understanding questionnaire. * poorly controlled concomitant diseases were excluded. * patients with past history of any sexual problems prior to the first ms attack. * un married patients.
impact of renovations in long term care living spaces on residents with dementia, their families and staff

Conditions: Dementia

Summary: a long-term care facility in central canada planned to renovate their existing dementia care units. the overarching objective of this study was to examine the effects of the renovations on residents, family, and staff.

a long-term care facility in central canada renovated their existing dementia care units, which accommodates 60 residents with intermediate and advanced stages of dementia. the primary features of the renovation include physical upgrades and the addition of a large u-shaped activity pavilion. the overarching objective of this study was to examine the effects of these design transformations in the facility and grounds on residents, family, and staff. the overall project addressed the following questions: * how does the long-term care unit renovation affect the health outcomes, quality of life, and lived experiences of residents? * what are the effects of the long-term care unit renovation on care staff and family members? * what aspects of the transformation were responsible for observed changes? and what aspects worked or did not? a multi-component, mixed-methods (qualitative and quantitative) research plan was used in this project. personal (resident, families, staff) and environmental variables (social interactions, implementation and use of technology and physical space) were assessed pre-renovation (spring/summer 2017) and post-renovation (summer 2019 and 2020). due to the covid-19 pandemic, plans for additional data collection in the summer of 2020 were not completed. with this mixed-methods research plan, the investigators gained valuable information about the renovation that is important for long term care facilities.

Eligibility criteria:
resident inclusion criteria: * currently living on special care unit for residents with intermediate to advanced dementia or cognitive impairment in a long-term care facility family member inclusion: * must have a family member/friend/neighbour currently living on the special care unit. * for the qualid, the family member must have visited the resident at least three out of the last seven days family member exclusion criteria: * must be able to participate in-person. * must be able to communicate in english. * must be cognitively able to participate. staff inclusion criteria: * must currently work on the special care unit (either full or part-time or occasional) * for the survey, staff must be able to read and understand english.

Keywords: long-term care renovations residents family staff
music therapy to promote emotion and cognition for dementia

Conditions: Dementia

Summary: the purpose of this study is to determine if the effects of music therapy alter emotion and cognition performances of individuals with mild to moderate dementia. the music therapy intervention protocol is structured by drum improvisation, rhythm imitation, music cognition and song discussion. attentive listening and active participation of the music training activities allow participants to utilize their focus of attention and comprehension of informational texts. music therapy intervention is proposed to provide positive stimulations on emotion and cognitive functions of individuals with dementia. the results of the present study will clarify relationship between the effect of music therapy and the neural substrate of music therapy in anatomical and functional brain data obtained from mri (fmri).

individuals with dementia often exhibit deterioration in cognitive functions and experience changes in emotions and personalities. due to the changes in the frontal and temporal lobes of the brain, individuals with dementia often experience an impaired ability to judge situations. empirical studies have indicated that cognitive stimulation is essential to facilitate individuals with dementia in thinking, concentration, and memory. structured music activities provide cognitive stimulation to individuals with dementia through attentive listening and active participation. additionally, drum improvisation not only reflects the current status of an individual, but also serves as an audio feedback through free play.

Eligibility criteria:
inclusion criteria: * a mild dementia diagnosis with clinical dementia rating (cdr) score: 1 and the mini mental state examination (mmse) score: 18-24 exclusion criteria: * significant visual and hearing impairment that hinders music listening and score reading * for fmri safty: with shrapnel or other metal or electronic implants in their bodies

Keywords: dementia drumming emotion cognition functional mri
investigation of the serum mucoprotein 3 (muc3) protein levels in gestational hypertensive disease

Conditions: Muc3; Pregnancy Induced Hypertension

Summary: hypertensive diseases of pregnancy are one of the most frequently encountered reasons for maternal and neonatal morbidity and mortality. the excretion of high levels of mucoprotein takes part in the pathogenesis of preeclampsia through restraining trophoblast invasion. this study aimed to investigate levels of serum mucoprotein three in hypertensive diseases of pregnancy. this study included a total of eighty cases that 20 normal pregnancy, 20 gestational hypertension, 20 preeclampsia, and 20 hellp syndrome patients from june 2010- january 2011.

hypertensive diseases of pregnancy are one of the most frequently encountered reasons for maternal and neonatal morbidity and mortality. the excretion of high levels of mucoprotein takes part in the pathogenesis of preeclampsia through restraining trophoblast invasion. this study aimed to investigate levels of serum mucoprotein three in hypertensive diseases of pregnancy. this study included a total of eighty cases that 20 normal pregnancy, 20 gestational hypertension, 20 preeclampsia, and 20 hellp syndrome patients from june 2010- january 2011. this is the first study measuring levels of serum mucoprotein three in gestational hypertensive disease. muc3 levels showed a distinctive increase in hypertensive diseases of pregnancy compared with the pregnant control group. as a result, it is found that plasma mucoprotein 3 levels increase as the severity of hypertensive diseases of pregnancy increases; and plasma mucoprotein 3 could be a precursor for the evaluation of the severity of the disease.

Eligibility criteria:
inclusion criteria: * to accept the consent to participate in the research and sign the form, * according to acog 2002, pregnancy meets the criteria of hypertensive diseases \[1\], the diagnosis of hellp syndrome was made according to the criteria described by sibai. these; abnormal peripheral smear, schistocyte in the peripheral smear, lactate dehydrogenase \> 600 u / l, hemolysis, total bilirubin\> 1.2 mg / dl, ast\> 70 u / l, platelet count \<100,000mm3. * when the demographic characteristics and cvs of all cases were questioned in the initial evaluation, not having chronic inflammation or acute infection, not having any systemic disease, recurrent pregnancy loss, thrombophilia, antiphospholipid antibody syndrome, * not smoking, no history of cancer, no multiple pregnancies * not using antihypertensive, anticoagulant, nsaid, corticosteroid or antiplatelet and antiepileptic drugs exclusion criteria: * using antihypertensive, anticoagulant, nsaid, corticosteroid or antiplatelet and antiepileptic drugs * smoking,history of cancer, multiple pregnancies

Keywords: muc3 preeclampsia eclampsia hellp
pain management after adductor canal block for total knee arthroplasty

Conditions: Knee Osteoarthritis; Knee Arthritis; Knee Arthropathy; Knee Pain Chronic

Summary: this randomized, double-blinded, placebo-controlled trial sought to evaluate the efficacy of the ipack block with adductor canal block on postoperative pain, functional recovery and nlr and plr levels.

the interspace between the popliteal artery and capsule of the posterior knee, or ipack block, together with the adductor canal block (acb), has been described and shows promise in providing analgesia to the knee joint. however, the effect of these two blocks on postoperative pain levels, functional recovery, and stress response is uncertain. this study compares a preoperative ipack and acb block to sham blocks before total knee arthroplasty under spinal anesthesia.

Eligibility criteria:
inclusion criteria: * patients \> 18 years old undergoing unilateral total knee arthroplasty exclusion criteria: * refusal to participate * \< 18 yo * chronic opioid use * localized infection

Keywords: ipack adductor canal block pain management multimodal analgesia peripheral nerve block knee arthroplasty
ocd among patients with burns

Conditions: Obsessive-Compulsive Disorder; Burns

Summary: estimating the prevalence of ocd symptoms among patients with burns


Eligibility criteria:
inclusion criteria: * patients with burns for at least 6 months and are under treatment exclusion criteria: * was not defined
universal endometrial cancer dna sequencing for detection of lynch syndrome and personalized care

Conditions: Endometrial Adenocarcinoma; Endometrial Carcinoma; Lynch Syndrome; Relatives

Summary: this clinical trial studies universal screening for deoxyribonucleic acid (dna) mismatch repair deficiency in patients with endometrial cancer, mutations in the genes responsible for lynch syndrome (inherited forms of endometrial cancers) and other dna changes that could help guide treatment strategies. universal tumor dna sequencing may help doctors better understand how to personalize care, increase length of life, and increase quality of life in patients with endometrial cancer and their relatives.

primary objectives: i. molecular classification of tumor abnormalities through innovative upfront next-generation dna sequencing. ii. identify endometrial cancer (ec) patients with inherited ec, specifically lynch syndrome (ls), using both tumor and normal (blood) dna testing. iii. develop a comprehensive approach to genetic risk assessment and management including improved cascade testing in at-risk relatives. iv. provide local access to genetic counseling for patients with harmful germline mutations. v. identify molecular signatures that may be associated with favorable response to specific treatments (including chemotherapeutic agents, non-surgical options, and novel clinical trials \[in particular, patients with mismatch repair (mmr)-deficient or pole-mutant tumors\]). vi. determine if recurrence likelihood can be predicted from molecular signature. vii. identify ec patients with select molecular signatures for recruitment to long-term follow-up, cancer prevention, and treatment studies. outline: patients with endometrial cancer undergo clinical testing for inherited cancer mutations using blood dna and via next-generation sequencing of tumor samples. patients testing positive for lynch syndrome or other cancer susceptibilities will undergo genetic counseling and testing and counseling will be offered to their family members.

Eligibility criteria:
inclusion criteria: * adult women who had a hysterectomy or diagnostic biopsy proving endometrial adenocarcinoma (any stage) between 10/1/2017 and 4/30/2020, and received care at one of the participating hospitals * adult relatives of the ec patients found to have ls exclusion criteria: * individuals must be able to speak and read english; non-english speaking individuals will be excluded * individuals must be able to consent for themselves; those who are unable to consent for themselves for any reason will be excluded * prisoners will be specifically excluded from participation in the study * women who have uterine sarcomas are excluded * pregnant women are not eligible for the study
alpha-linolenic acid and the risk of ascvd

Conditions: Acute Myocardial Infarction; Ischemic Stroke; Peripheral Artery Disease

Summary: background: the plant-derived omega-3 fatty acid alpha-linolenic acid (ala, 18:3-n-3) may reduce the risk of atherosclerotic cardiovascular disease, including incident myocardial infarction, ischemic stroke and peripheral artery disease. however, the results of previous studies have been inconsistent. objectives: to investigate the associations between dietary intake of ala, adipose tissue content of ala, and the risk of the major atherosclerotic cardiovascular diseases incident myocardial infarction, ischemic stroke and subtypes, and peripheral artery disease. methods: this project will be based on data from the danish cohort study diet, cancer and health which consisted of 57,053 men and women at recruitment between 1993 and 1997. dietary intake of ala will be assessed using a validated semiquantitative food-frequency questionnaire and adipose tissue content will be determined with the use of gas chromatography analyses of adipose tissue biopsies collected at baseline. also, detailed information on lifestyle factors, medical history and anthropometri was collected at baseline. incident cases have been identified through national registries and the diagnoses have previously been validated. analyses of dietary intake of ala will be analysed using a traditional cohort design, whereas analyses on adipose tissue content of ala will be analysed based on a case-cohort design. hazard ratioes with 95% confidence intervals will be used to describe the associations between the exposure variables and the outcome variables of interest.


Eligibility criteria:
inclusion criteria: * born in denmark * age between 50 and 64 years * living in the areas of copenhagen and aarhus exclusion criteria: * previous cancer

Keywords: alpha-linolenic acid dietary intake adipose tissue nutritional epidemiology
cross-sectional, non-randomized observational study to assess the frequency of reduced sodium intake in the primary care setting - laxap

Conditions: Dietary Deficiency; Sodium

Summary: this study is a cross-sectional epidemiological, observational study. it would be carried out in primary health care sites. the purpose of this study is estimating the percentage of patients aged 60 years or older who suffer from a condition, or take medication, associated with a low or sodium-free diet in primary care consultations. this is a cross-sectional epidemiological study of data collection without medication. participants data will be collected after obtaining their confirmation through an informed consent from. no medication will be given to patients.


Eligibility criteria:
inclusion criteria: * patients seen in the primary care unit, in person, with inclusion beginning in order of care in consultation from the beginning of the study. * age greater than or equal to 60 years. exclusion criteria: not applicable