Kornimate/medical-research-clean huggingface dataset:
to study the concentration level of, doxil, and doxorubicin at various time frames

Conditions: Lymphoma Leukemia

Summary: doxil or doxorubicin to be administered was administered in a dose of 50 mg/m2 as infusion over 15 minutes. blood samples to be obtained at 0, 1, 2, 3, 4, 8, 12, 24, 48 and 72 hours

comparison of auc in a single dose of doxorubicin vs single dose of doxil \[ time frame: 0, 1, 2, 3, 4, 8, 12, 24, 48 and 72 hours. cycle is defined as 28 days) the primary objective of this study is to determine the pharmacokinetic equivalence of doxorubicin and doxil as a single dose in patients with carcinomas, lymphomas and leukemia's. the outcome measure will be determined by analyzing the concentration from each patient at pre-specified time points and calculating area under the curve (auc) and peak plasma concentration (c max)to determine % variability between doxorubicin and doxil within each patient.

Eligibility criteria:
inclusion criteria: * ages eligible for study: 18 years to 75 years (adult, older adult) sexes eligible for study: all accepts healthy volunteers: no criteria inclusion criteria: have confirmed diagnosis of lymphomas. leukemia's and carcinoma to be treated with doxil or doxorubin have a normal left ventricular ejection fraction (lvef) based on institutional ranges. be \>/= 18 and \</= 75 years of age sign a written institutional review board (irb)-approved informed consent form have a negative pregnancy test, if patient is of child-bearing potential. agree to use effective contraceptive methods during the study (nonsterile patients of childbearing potential) have acceptable liver function, renal function and hematologic status based on the institution. exclusion criteria any medical related exclusion criteria as per the institution. are unwilling or unable to comply with procedures required in this protocol have known infection with human immunodeficiency virus (hiv), hepatitis b, or hepatitis c have a serious nonmalignant disease (e.g., hydronephrosis, liver failure, significantly impaired hepatic function, or other conditions) that could compromise protocol objectives in the opinion of the investigator and/or the sponsor are currently receiving any other investigational agent have exhibited allergic reactions to doxorubicin or a similar structural compound
hyperbaric oxygen and its effect on radiation induced long term side effects

Conditions: Cancer of Head and Neck

Summary: the investigators intend to determine if patients that are already undergoing hyperbaric oxygen (hbo) therapy one year post treatment with radiation therapy for head and neck cancer, experience improvement in xerostomia and/or taste alteration. the investigators will enroll a similar demographic one year post treatment with radiation therapy that does not receive hbo therapy. this is a quality of life study.

radiation therapy is a commonly utilized treatment modality for head and neck cancer patients. xerostomia (i.e. dry mouth) (and taste change) are common and most significant side effects of this treatment. xerostomia leads to several complications for patients including difficulty in chewing, speaking, swallowing, taste and smell abnormalities, oral infections and inflammation, osteoradionecrosis, dental caries and periodontal disease. these conditions tend to lead to an overall decreased quality of life for patients affected. a possible modality for the treatment of xerostomia is the use of hyperbaric oxygen (hbo) therapy. hbo is the medical use of oxygen at a level higher than atmospheric pressure. it has been proposed that hbo results in accelerated blood vessel growth and repair in tissue injuries by increasing the oxygen partial pressure gradient (bennett, 2005). today, the use of hbo is widely accepted for both the treatment and prevention of radiation induced toxicities such as osteoradionecrosis and soft tissue necrosis. here at upstate university hospital, the investigators treat approximately 20 patients each year with hyperbaric oxygen for either the prevention or management of radiation induced complications such as osteoradionecrosis and /or soft tissue necrosis. the investigators would like to use this group of patients to evaluate the effect of hbo in the improvement of radiation induced xerostomia (and or taste change). the investigators' data will be collected from patients with the use of periodic quality of life questionnaires at 5 timepoints, as well as data relating to the treatment each patient was given. .

Eligibility criteria:
inclusion criteria: * males and females age \> 18 previous radiation therapy to the head and neck region at least one year from end of treatment exclusion criteria: * history of parotidectomy history of dementia
hiv and std prevention for high-risk, inner-city, african american youth

Conditions: HIV Infections; Sexually Transmitted Diseases

Summary: this study will evaluate the joint and separate effectiveness of two hiv/std prevention programs in providing protection against acquiring stds and maintaining safer sex behavior.

approximately 25% of the new hiv cases in the united states each year occur among adolescents. although african american teens make up only 15% of the adolescent population in the u.s., they account for about two thirds of new aids cases among teens. an atlanta, georgia study involving a population composed primarily of urban african american teens demonstrated that few of the teens who tested positive for hiv were aware of the risks involved in sexual activity. because of this population's increased risk for contracting hiv and other stds, prevention programs that specifically target african american teens are necessary. this study will evaluate the joint and separate effectiveness of two hiv/std prevention programs, small group training and mass media messages, in providing protection against acquiring stds and maintaining safer sex behavior. african american adolescents will be recruited for this single-blind, 18-month study through community-based organizations in four different cities. all participants will first complete a computer-administered survey to assess sexual attitudes, beliefs, and behaviors. they will also provide a urine sample for std testing. following these baseline assessments, participants will be randomly assigned to either the focus on youth (foy) hiv prevention program or the promoting health among teens general health intervention. both programs will involve eight 1-hour small group sessions that will occur over three saturdays. participants in the foy program will learn safe sex and abstinence skills. participants in the promoting health among teens intervention will receive general health information about diet, substance use, and appropriate screening for common health conditions other than stds. all participants who test positive for an std during the study will receive treatment. follow-up assessments will occur at months 6, 12, and 18 post-intervention to determine program effectiveness. the second prevention program, mass media messages, will be administered among all participating african american teens in one of the two participating northern cities and one of the two participating southern cities. cities that will receive the media intervention will be randomly selected. the other city in each pair will serve as a control city. tailored hiv/std prevention messages will be delivered through local mass media. telephone interviews will be conducted over a 34-month period among 900 randomly selected teens from both media and non-media cities to assess community-wide effectiveness of the program.

Eligibility criteria:
inclusion criteria: * currently resides in one of the test cities exclusion criteria: * presence of mental impairments

Keywords: adolescents sexually transmitted infections gonorrhea chlamydia infections
micro-wave ablation under organ-based tracking in patients with prostate cancer - fostine

Conditions: Focal Treatment for Prostate Cancer

Summary: with the advent of multiparametric mri (mpmri), the concept of focal therapy continues to develop as a compromise between active surveillance and radical tratment. however, it must be combined with the most stringent quality control measures, such as exceptional imaging, to allow close management of the index tumor. the choice of the energy is also crucial. several have been tested such as hifu, electroporation or cryotherapy. a new therapeutic alternative currently under investigation resides in the use of microwaves delivered through a thin needle inserted precisely into the index lesion according to the same procedure as targeted biopsy under image fusion to induce coagulation necrosis and lead to the tumor destruction. through an ablate, performed transrectally under real-time mri/trus image registration and 3d mapping, in patients with localized prostate cancer (pca).

patients with a detectable index lesion on mpmri, psa level \<20 ng/ml and wishing to undergo a prostatectomy due to significant pca on biopsy are elibible for this study approved by the ethics committee. targeted biopsies of the index lesion are performed by using an ultrasound-mri image fusion system with organ based tracking (obt)-registration (trinity\*, koelis, france) to provide quality control. targeted cores are analyzed intraoperatively with an extemporaneoux analyses. if positive, a targeted focal microwave ablation is achieved during the same session by a single 18g needle inserted transrectally under sedation. predictive ablation charts obtained with the 2.45 ghz frequency microwave generator (tato, biomedical srl, italy) through ex vivo experiments were used to choose the duration and power of the treatment. treated patients are followed-up for 4 to 6 weeks and the planned radical prostatectomy is performed. all treated patients complete uroflowmetry test and questionnaires (ipss, ipss-qql, iief-5, and mshw-ejd-sf) befor, at 7 days and 1 month after the procedure. a mpmri of the treated prostate is performed at 7 days after the ablation to identify the devascularized area, but also to verify that no organ at risk is affected by the microweve treatment. after radical prostatectomy, whole-mount histology serves to define the ablation boundaries and dimension in the prostate. it also allows to determine the impact of the use of microwaves on cancerous tissue. a total of 10 patients will be enrolled.

Eligibility criteria:
inclusion criteria: * patients with detectable index lesion on mpmri, psa level \<20 ng/ml and wishing to undergo a prostatectomy due to significant pca on biopsy. * life expectancy up to 10 years or plus. exclusion criteria: * past history of prostate surgery or pelvic radiotherapy, prostatitis, extra-capsular extension on mri or index lesion above 25 mm, distance between rectum and index lesion less than 5 mm.

Keywords: prostate cancer focal treatment for prostate cancer focal treatment
non-invasive neuromodulation guided through biomarkers in patients with stroke sequels

Conditions: Stroke

Summary: this study aims to investigate if the size effect of repetitive magnetic transcranial stimulation in the paretic upper limb in patients after stroke is influenced by the therapeutic decision.

after the patients and volunteers signed an informed consent form they will be classified and randomized using a website (randomization.com) by a non-involved researcher. all patients and volunteers will be assigned to groups (arms) after being tried: (i) rtms-dir: in which the patients will be submitted to a customized treatment with repetitive transcranial magnetic stimulation (rtms) based in neurophysiological assessments; (ii) rtms: patients will be submitted to standard treatment in the lesioned or non-lesioned hemisphere based in neurophysiological assessments; (iii) rtms sham: each patient will receive a sham intervention that emits the same sound as the real stimulation; in each group, the patients will be submitted to 10 sessions for two weeks, five days a week in which will receive the rtms followed by 45 minutes of neurofunctional physiotherapy. all outcomes will be assessed before and after the 10 sessions.

Eligibility criteria:
inclusion criteria: * more than 3 months after stroke; * ischemic or hemorrhagic stroke with upper limb motor impairment; exclusion criteria: * any contraindication for application of transcranial magnetic stimulation; * peripheral lesions in the assessed upper limb; * score ≤ 18 at folstein mini mental state examination; * alteration of drugs that alter the excitability of the cortex (in less than 3 months); * application of botulinum toxin in less than 6 months.

Keywords: transcranial magnetic stimulation electroencephalogram physiotherapy brain symmetry biomarker
the clinical application and mechanism of music therapy (mozart's effect) on epilepsy

Conditions: Seizure

Summary: music has a long history in healing physical and mental illness. the mozart effect was initially reported by rauscher, shaw, and ky in the journal of "nature" in the year of 1993. they examined performance on stanford-binet spatial tasks immediately following either 10 minutes of listening to mozart's sonata k.448, silence, or instruction to relax. they found the performance scores were 9 point higher in mozart-listening group than other two groups. later, the beneficial influence of mozart music on parkinson's disease, epilepsy, senile dementia, and attention-deficit/hyperactivity disorder was reported. however, the real neurophysiological mechanism of the influence remains unclear. epilepsy is a common disorder in the field of pediatric neurology. although we had greatly advanced in develop of new anticonvulsant, thirty percent of patients with epilepsy have drug-resistance, which is associated with an increased risk of debilitating psychosocial consequences. in addition, the adverse effects of anticonvulsants are not uncommon. few reports demonstrated that patients exposed to mozart's music can significantly decrease in seizure frequencies and interictal epileptiform discharge. however, the case number of these studies was limited and the mechanisms of music therapy on epilepsy were not well known. in our recent studies, mozart's music indeed decreased the epileptifrom discharge in the patients with epilepsy, particularly in the patients with generalized discharge and central discharge. on the basis of these encouraging results, we will try to investigate the neural mechanisms and clinical applications of music therapy in the following three years. in the first year of our study, we use animal model to examine the possible mechanism of mozart's effect. the aim of the second year study is investigation the effect of music on the cortical functions in the epileptic rat model. according to our previous study, mozart's sonata k.448 was effective in reducing epileptiform discharge. on the basis of previous two-year results, the patients with epilepsy will be enrolled in the third year project to perform an individualized music therapy. in this study, we can provide an alternative therapy in the patients of epilepsy and investigate the possible biological mechanism of music effect.

children with first unprovoked seizure were investigated.patients were randomly classified into treatment and control groups. they did not receive aed after their first unprovoked seizure. the treatment group listened to mozart k.448 for eight minutes once daily before bedtime for at least six months.all of the patients received follow-up telephone calls monthly. patients who experienced seizure recurrence were advised to begin aed treatment.

Eligibility criteria:
inclusion criteria: * children who had epileptiform discharges with first unprovoked seizure exclusion criteria: * epileptic children without epileptiform discharges

Keywords: mozart k.448 first unprovoked seizure epileptiform discharges music therapy children
evaluation of melatonin's effect on pain and blood loss after cesarean section

Conditions: Post Partum Haemorrhage in Patients Undergoing Cesarean Section

Summary: the purpose of this study is to assess the effect of melatonin on pain and amount of blood loss after cesarean delivery one hundred twenty women with singleton term pregnancy undergoing elective or emergency lower segment cesarean section under spinal anesthesia were included in this study. the patients were randomly allocated to one of three groups of 40 each to receive sublingual 3 mg melatonin or 6 mg melatonin or placebo before spinal of anesthesia . in all patients 20 iu syntocinon which dissolved in 0.5liter of lactated ringer's solution) at the rate of 500 ml over a 15 minutes period, immediately after delivery of the neonate was infused . time to first requirement of analgesic supplement, hemodynamic variables,will be recorded.patients were instructed preoperatively in the use of the verbal rating scale (vrs) from 0 to 10 (0no pain, 10maximum imaginable pain) for pain assessment. if the vrs exceeded four and the patient requested a supplement analgesic, diclofenac na supp 100 mg was to be given for post-operative pain relief as needed . for breakthrough pain(vrs \>4) if time of administration of diclofenac na less than 8h,pethidine 25 mg iv was given. for determination of blood loss ,change in hemoglobin levels, need for additional oxytocics and ,the volume of blood in the suction bottle was measured, blood soaked sponges. hemoglobin values were determined both before surgery and 12 h following surgery


Eligibility criteria:
inclusion criteria: * pregnant women at term (37-40 wks) gestation scheduled for either elective or emergency lower segment cesarean section exclusion criteria: * women with any risk factor associated with an increased risk of postpartum hemorrhage were excluded i.e. multiple gestation, antepartum hemorrhage,poly-hydramnios, two or more previous cesarean sections and/or a history of previous rupture uterus * current or previous history of significant disease including heart disease, liver, renal disorders ,anemia (hb8 g%)or known coagulopathy

Keywords: post partum haemorrhage cesarean pain
moderated-fat diet complemented with green tea reduces oxldl and fat mass in obese women

Conditions: Nutritional and Metabolic Disease

Summary: background: obesity is a chronic degenerative disease, considered as cardiovascular risk factor, characterized by systemic inflammation and high levels of oxldl. clinical studies have suggested that drink green tea could improve these complications. objective: analyze the effect of a moderate-fat diet complemented with green tea on oxldl, fat mass and tnfa in obese women. design: randomized, controlled clinical trial. obese women, without other chronic-degenerative disease were divided using a computer-generated random sequence: control group (con) with n=32, and intervention group (int) with n=32; and were instructed to consume a moderate-fat diet, and int group was instructed to complement the diet with green tea. anthropometric and biochemical measurements were performed, and oxldl and tnfa s levels were determined by elisa. all parameters were realized at baseline and in the 1st, 2nd and 3rd months post-intervention. tnfa mrna expression was determined by real-time rt-pcr (basal and final). the changes on lipid profile, oxldl, fat mass and tnfalpha expression were reported of the comparison between basal and final time points. the statistical analysis was performed with spss software.

the investigators assessed 114 women with the eligibility criteria: obese women older than 18y, in good health, as determined by a medical history questionnaire, and normal results of clinical laboratory tests excluding lipids. exclusion criteria was: history of cardiovascular, hepatic, gastrointestinal, or renal disease; no alcoholism, no smoking, no exogenous hormone use or other medication; no supplemental vitamin or infusion drinking (tea, coffee); or treatment for weight loss 3 months before the start of the study. a total of 64 female, mexican obese patients were included. we conducted the trial between april 2007 and december 2007 in guadalajara, jalisco, mexico. all of the studies were conducted at departamento de biología molecular en medicina, hospital civil "fray antonio alcalde". this study was approved by the ethical committee for human research, universidad de guadalajara (registration number 028/10). the procedures were in accordance with this institution's guidelines and written consent was obtained from each study subject.

Eligibility criteria:
inclusion criteria: * obese women older than 18 years, * in good health, as determined by a medical history questionnaire, and * normal results of clinical laboratory tests excluding lipids exclusion criteria: * history of cardiovascular, hepatic, gastrointestinal, or renal disease; * no alcoholism, no smoking, no exogenous hormone use or other medication; * no supplemental vitamin or infusion drinking (tea, coffee); or * treatment for weight loss 3 months before the start of the study

Keywords: green tea oxldl fat mass
phosphodiesterase inhibitors, pentoxifylline, as adjunctive therapy in patients with ulcerative colitis.

Conditions: Inflammatory Bowel Diseases

Summary: ulcerative colitis (uc) is an idiopathic, chronic inflammatory disease characterized by diffused inflammation of the colon and rectum mucosa; however, the exact underlying mechanisms of uc remain poorly understood. also, it is associated with high risk of colon cancer, so there is a continuous need for introducing new therapies that decrease progression, and hence better outcomes


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * both males and females will be included * negative pregnancy test and effective contraception. exclusion criteria: * breastfeeding * significant liver and kidney function abnormalities * colorectal cancer patients * patients with severe uc * patients taking rectal or systemic steroids * patients taking immunosuppressives or biological therapies * addiction to alcohol and / or drugs