Kornimate/medical-research-clean huggingface dataset:
aln-apoc3 in adult participants with dyslipidemia

Conditions: Dyslipidemia

Summary: this study is researching an experimental drug called aln-apoc3 (called "study drug"). the study is focused on participants who have dyslipidemia (abnormal amounts of fats in the blood, including triglycerides and cholesterol), but who are otherwise healthy. the aim of the study is to see how safe and effective the study drug is. the study is looking at several other research questions, including: * what side effects may happen from taking the study drug * how much study drug is in the blood at different times * how the study drug changes lipid levels in the blood

the study will be conducted in 2 parts, part a and part b. participants in part a will be excluded from participating in part b.

Eligibility criteria:
key inclusion criteria: 1. judged by the investigator to be in in good health based on medical history, physical examination, vital signs, electrocardiograms (ecg's) and laboratory safety testing, as defined in the protocol 2. participants can enter the study under one of the following options, as defined in the protocol: 1. currently not taking statin and have not been on statin therapy for the 3 months prior to screening, or 2. on a stable dose of statin, taken continuously for 3 months 3. fasting triglycerides concentrations ≥100 and \<500 mg/dl (1.13 to 5.65 mmol/l) during screening visit, as defined in the protocol 4. fasting ldl-c ≥70 (1.81 mmol/l) if on stable statin therapy or if not on statin treatment, as defined in the protocol key exclusion criteria: 1. history of clinically significant cardiovascular (other than dyslipidemia), respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, psychiatric, or neurological disease, or any other concern, as assessed by the investigator that may confound the results of the study or poses an additional risk to the participant by study participation 2. was hospitalized (ie, \>24 hours) for any reason within 30 days of the screening visit 3. is positive for human immunodeficiency virus (hiv) or hepatitis b surface antigen (hbsag) at the screening visit, as defined in the protocol 4. is positive for hepatitis c antibody and positive for qualitative hepatitis c virus (hcv) ribonucleic acid (rna) test at the screening visit 5. any malignancy, except for non-melanoma skin cancer or cervical/anus in-situ, that have been resected with no evidence of metastatic disease for 3 years prior to the screening visit note: other protocol defined inclusion/exclusion criteria apply

Keywords: lipids triglycerides cholesterol
stepping-up: partnering with the community to prevent early mobility decline

Conditions: Mobility Limitation

Summary: preclinical mobility limitations (pcml) manifest early in the process of declining mobility, and are not typically identified or acted upon by clinicians. these mobility limitations manifest as changes in how daily tasks such as walking are performed (slower speed, lower endurance). persons in the pcml stage are at increased risk for the onset of disability and chronic disease. persistent deterioration in mobility is a predictor of mortality and has been reported even in the absence of changes in activities of daily living over a two-year period. further, older persons with mobility limitations, including reduced gait speed, are at risk for falls. these cumulative transitions of a person's life-long mobility form their mobility trajectory and preventing mobility decline at an early stage along this trajectory is the focus of this research initiative. this study will evaluate a novel intervention, stepping-up, for improving walking ability in persons with pcml.


Eligibility criteria:
inclusion criteria: 1. community-dwelling 2. age ≥55-75 years 3. pcml as assessed using a questionnaire that requires respondents to self-report difficulties with their mobility (walking 2.0km). respondents will be considered in a stage of pcml if they report no task difficulty but report modification of task performance (i.e. modify frequency, method or time to complete the task) 4. understanding of spoken and written english 5. own a laptop computer, have an email address and have internet capabilities of running the video-conferencing platform, zoom©. 6. resident of ontario, canada exclusion criteria: 1. a score of \<11 on the moca 5-minute telephone screen 2. major illness that would prevent participation

Keywords: preclinical mobility limitation walking ability physical function task-oriented motor learning self-management
benefit of the chalaxie pedagogical tool in the management of overweight or obese children with intellectual disability : a pilot monocentric prospective study.

Conditions: Pediatric Obesity

Summary: the main objective of this study is to determine the benefit of the chalaxie pedagogical evaluation tool in the management of overweight or obese children with intellectual disability. chalaxie is a software developped as a pedagogical evaluation tool. it is used in the therapeutic education of overweight and obese children and allow the clinican to explore several skills of the child, such as self-esteem.

secondary objectives 1. to assess the feasibility of the chalaxie tool use during a medical visit; 2. to assess the relevance of the chalaxie tool for the pediatrician; 3. to describe the characteristics of the patients followed at the "réseau ode"; 4. to evaluate patient self-esteem. conduct of research after receiving written consent from the study participant and parental authority, the patients will have two visits with the pediatrician during which they will use the chalaxie pedagogical evaluation tool. at the first visit, they will use the self-esteem assessment module. at the second visit (i.e. final visit), which should take place between 3 weeks and 2 months after the first visit, they will use a module of their choice.

Eligibility criteria:
inclusion criteria: * minor patient of 11 years of age or older * overweight or obese patient respectively defined as a bmi ≥ iotf 25 and ≥ iotf 30 * mild intellectual disability defined as intelligence quotient (iq) ≥ 55 and \<70 or (if iq unknown) patient in a special education institution (ulis, im-pro) * affiliated or beneficiary of a social security scheme * written consent of the patient and one of the parental authority holder exclusion criteria: * patient with a severe autistic disorder * patient who already used the chalaxie tool during his/her follow-up * difficulties in understanding the instructions for using the software and/or difficulties in using a computer

Keywords: intellectual disability patient therapeutic education pedagogical evaluation
comparison of the efficacy of different nerve stimulation methods in individuals with chronic consipation

Conditions: Constipation

Summary: consipation is the most common digestive complaint in the general population. the normal frequency of defecation ranges from a minimum of three times a week to a maximum of two times a day.

constipation is one of the most common health problems in the geriatric population, negatively affecting the physical and emotional status of individuals. constipation can be classified into three main groups: normal transit time constipation, slow transit time constipation and dyssynergic defecation disorders . treatment in chronic constipation should be directed towards the underlying cause. in the treatment of chronic constipation, lifestyle modifications and physiotherapy are the first, pharmacologic treatment is the second, and surgical treatment is the third. physiotherapy modalities such as defecation training, classical massage, electrical stimulation, anorectal biofeedback and exercise training can be used in the treatment of chronic constipation.

Eligibility criteria:
inclusion criteria: * 18-65 ages female * rome iii diagnostic criteria exclusion criteria: * severe heart or kidney diseaseprevious gastrointestinal, spinal or pelvic surgery other than cholecystectomy, hysterectomy or appendectomy neurological diseases such as multiple sclerosis, stroke, parkinson's disease or spinal injury, * impaired awareness (mini-mental score \< 15), * legal blindness, pregnancy, * rectal prolapse * anal fissure and altered constipation and diarrhea pattern.

Keywords: constipation
pharmacokinetic study on echinocandins for patients with septic shock following secondary peritonitis

Conditions: Septic Shock; Peritonitis

Summary: the main objective of this study is to describe the pharmacokinetics of the prescribed echinocandins for septic shock with secondary peritonitis for which intra-abdominal fungal infection is suspected or proven.

the secondary objectives of this study are: * determine whether the current recommended doses of caspofungin achieve the pharmacokinetic/pharmacodynamic (pk/pd) target for this molecule. * determine whether the current recommended doses of micafungin achieve the pk / pd target for this molecule * describe the peritoneal concentrations of echinocandins in secondary peritonitis complicated with septic shock * identify via modeling pk / pd parameters and based on monte carlo simulations the optimal dosing regimen for caspofungin and micafungin in this population

Eligibility criteria:
inclusion criteria: * the emergency inclusion procedure was correctly applied according to french law (signature of consent form by a patient-designated trusted person or a family member, or a medical decision to proceed with patient inclusion if the latter two persons are unavailable) ---- or ---- signature of the consent form by the patient * the patient must be insured or beneficiary of a health insurance plan * the patient is 18 years of age or older * the patient has beed admitted to the icu for septic shock accompanying secondary peritonitis * patient requiring antifungal treatment via echinocandins (caspofungin or micafungin) * a venous or arterial access for blood sampling is already in place for routine care exclusion criteria: * the patient is participating in an interventional study that may affect the results of the present study, or has participated in such a study within the past 3 months * the patient is under judicial protection, or is an adult under guardianship * the patient is pregnant, parturient or breastfeeding * moribund patient * known positive serology for human immunodeficiency virus (hiv) * known positive serology for hepatitis c * known diagnosis for tuberculosis
diagnosis and natural history study of patients with neurological conditions

Conditions: Alzheimer's Disease; Dementia; Movement Disorder; Multiple System Atrophy; Parkinson's Disease

Summary: the purpose of this study is to improve understanding of neurological conditions. patients participating in this study will continue receiving medical care, routine laboratory tests, and diagnostics tests (x-rays, ct-scans, and nuclear imaging), from their primary care physician. doctors at the nih plan to follow these patients and offer advice and assistance to their primary care physicians.

the objective of this protocol is to provide diagnosis and follow experimental therapeutics branch (etb) patients not currently entered on another research protocol. no investigational treatments will be administered on this protocol, and the nih physicians will be playing largely a consultative role to the patient's primary physician.

Eligibility criteria:
inclusion criteria: patients may be included on this protocol if they have an identifiable neurological disorder or represent a diagnostic puzzle. these disorders would include patients with parkinson's disease, alzheimer's disease, multiple system atrophy, progressive supranuclear palsy, restless legs syndrome, other cognitive and movement disorders, and diagnostic puzzles. patients 18-90 years of age, inclusive, are eligible.

Keywords: movement disorders parkinson's alzheimer's screening diagnostic puzzles alzheimer disease progressive supranuclear palsy psp restless leg syndrome rls parkinsonism pd
treatment of knee osteoarthrosis using the electromagnetic fields

Conditions: Knee Osteoarthritis; Knee Arthritis

Summary: this study is a randomized controlled clinical trial using a blind evaluator. fifty-one volunteers were selected from 50 years to 70 years, obeying the following criteria: diagnosis of knee oa grade ii and iii through the radiographic classification of kellgreen and lawrence 1955, body mass index (bmi) less than 40 kg / m², volunteers should have had knee pain for at least six months. all are from the rehabilitation sector of santa casa de misericórdia de são paulo (iscmsp). the subjects were evaluated through a questionnaire developed by the authors of the study (annex i), the visual analogue scale (eva) (annex ii), then applied to the lower extremity functional scale lefs (appendix iii) and the activities of daily living scale adls (annex iv). in addition, the evaluation of muscular strength was through dynamometry using the lafayete dynamometer model 01163, which was performed by a blind evaluator regarding the group that will belong to each candidate. the muscles tested were: quadriceps, ischiostibial and gluteus maximus. the randomization was through 60 brown envelopes divided into a, b, c and d, designating the randomness of the sample. in addition to the initial evaluation, an evaluation was performed at the end of the tenth session and after 3 months of treatment. the volunteers underwent a five-week treatment program, totaling 10 sessions, divided into four groups, group a - intervention (int) underwent knee and hip muscle strengthening exercises and electromagnetic field therapy with (meditea - arg) using the coplanar technique, group b - exercises (exe) carried out exercises to strengthen the hip and knee muscles in the c - placebo group (pla). hip and knee and electromagnetic field therapy with the magnetron® coplanar technique, but with the device switched off and group d - apparatus (apa) only use electromagnetic field therapy with the magnetron® coplanar technique. in the present study, there were no significant differences between groups regarding pain, function and muscle strength. however, group a obtained better results in the evaluated criteria, tending that the combination pemf and exercises, is an indicated treatment for oa knee.


Eligibility criteria:
inclusion criteria: * diagnosis of knee oa grade ii and iii * body mass index (bmi) of less than 40 kg / m² * knee pain for at least six months exclusion criteria: * severe oa above grade 3 * previous physical therapy for at least 6 months, * any other affection of the lower limbs (lll) and lumbar spine, * obesity (bmi\> 40), * patients with cardiovascular, metabolic, neurological, oncological or history of knee surgery.
prevention of musculoskeletal injuries in musicians

Conditions: Cervical and Mandibular Pain and Disorders in Wind Players

Summary: musicians are a group with a high prevalence of musculoskeletal injuries. in particular, wind musicians, due to their playing requirements, are prone to suffer from cervical and mandibular alterations. for this reason, a specific exercise programme has been designed with the aim of analysing its effectiveness in improving these regions.

this study is a clinical trial with a control group whose participants are university music students specialising in wind instrument performance. the intervention of the participants in the experimental group consists of the individual performance of a specific programme of warm-up exercises prior to instrumental practice aimed at improving the mobility and strength of the cervical and mandibular regions, as well as a series of cool-down exercises after instrumental practice based on stretching the main muscles of both regions. participants in the control group will continue their normal life without performing any specific exercise previously taught by the researchers. for the evaluation of the programme, an initial evaluation and a re-evaluation after 12 weeks will be carried out. in both, cervical and jaw mobility as well as body posture will be assessed. in addition, at the muscular level, the activity of the upper trapezius and masseter muscles will be assessed, and the pain threshold at trigger points will also be measured. the hypotheses are that by carrying out the exercise programme designed for wind musicians, an improvement in body posture, in the range of cervical and jaw mobility and in muscle activation will be achieved, as well as a decrease in the pain threshold. for the study of the results, an inferential statistical analysis of the data will be carried out using the wilcoxon test for paired data or student's t-test for repeated measures according to the sample characteristics in order to determine the effect of the exercise programme on the different variables of the experimental process. correlation statistics will be used to establish the association between certain quantitative explanatory variables and anova for categorical variables. the level of significance will be kept at p\<.05 and all calculations will be carried out using the spss 22.0 statistical programme.

Eligibility criteria:
inclusion criteria: * woodwind or metal musicians * university students of music performance exclusion criteria: * any surgical intervention in cervical spine, orofacial region or temporomandibular joint. * analgesics or physiotherapeutic treatment in the last 24h. * pregnancy

Keywords: musculoskeletal pain neck pain temporomandibular disorders posture musician
comparison in marginal adaptation between conventional and gull wing preparation in laminates veneers

Conditions: Teeth Sensitivity

Summary: the aim of this study is to evaluate tooth sensitivity and marginal adaptation of porcelain laminates veneers prepared with modified gull wing preparation and conventional preparation.

visit 1: preoperative records, face-to-face adherence reminder session, clinical, radio-graphic examination and primary impression for diagnostic cast construction. visit 2: teeth preparation, secondary impression,temporary restoration and teeth sensitivity evaluation using united states public health service criteria. visit 3: placement and permanent cementation of the final restoration visit 4: marginal adaptation measurement by electron microscope using impression replica.

Eligibility criteria:
inclusion criteria: * from 18-40 years old, be able to read and sign the informed consent document. * be physically and psychologically able to tolerate conventional restorative procedures. * have no active periodontal or pulpal diseases, have teeth with good restorations. * patients with teeth problems indicated for laminate veneer (e.g:discoloration, fracture not involve more than 50% enamel loss, mild malposition. * be willing to return for follow-up examinations and evaluation. exclusion criteria: * patients in the growth stage with partially erupted teeth. * patient with fractured teeth of more than 50% enamel loss. * patients with poor oral hygiene and motivation. * pregnant women. * patient with post and core endodontically treated teeth. * psychiatric problems or unrealistic expectations. * lack of opposite occluding dentition in the area intended for restoration
anti-neutrophil cytoplasmic antibody in interstitial lung disease.

Conditions: Interstitial Lung Disease; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Summary: the purpose of this study is to investigate the clinical features and long-term outcome of anti-neutrophil cytoplasmic antibody (anca)-positive interstitial lung disease (ild) and assess the difference between microscopic polyangiitis (mpa) associated ild and isolated anca-positive idiopathic interstitial pneumonia.

ild patients with serum anca-positivity were enrolled in this study. 1. baseline data collection: 1. demographics information (age, gender) 2. clinical course 3. clinical symptoms and signs (cough, dyspnea, fever, fatigue, crackling, clubbing fingers, mechanics hand) 4. laboratory findings (blood and urine routine, liver and renal function tests, erythrocyte sedimentation rate, c reactive protein) 5. serologic tests (ana , rheumatoid factor , anti-cyclic citrullinated peptide (ccp), anti-dsdna, anti-ro (ss-a), anti-la (ss-b), anti-smith, anti-scl-70, anti-jo-1) 6. systemic manifestation if diagnosed as systemic vasculitis 7. pulmonary function tests (ventilation and diffusion capacity test) 8. chest high-resolution computed tomography (hrct) 2. treatment: treatment will be given according to the experience of each pulmonologist. 3. follow-up: 1. patients were followed up at least once a year and basic laboratory tests, serologic autoantibodies, pulmonary function test and chest hrct were evaluated routinely 2. follow-up end point was april 2019. 4. outcome

Eligibility criteria:
inclusion criteria: * males and females * aged from 18 to 85 years with informed consent * have a diagnosis of ild based on clinical symptoms and radiologic features, with or without histopathologic results * have available anca testing results during the first visit and follow-up period exclusion criteria: * connective tissue disease associated ild * ild induced by drug, environment, or occupational exposure * hypersensitivity pneumonitis and sarcoidosis

Keywords: interstitial lung disease anti-neutrophil cytoplasmic antibody anti-neutrophil cytoplasmic antibody-associated vasculitis
protective effects of exercise training

Conditions: Sleep Deprivation

Summary: rationale. sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction. objective. to determine if 7 weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (tsd) in healthy young men. methods: 16 subjects will be examined during 40-h tsd, both before and after 7 weeks of interval exercise training. vasodilatation induced by ach, insulin and heat (42°c) as well as pulse wave velocity (pwv), blood pressure and heart rate (hr) will be assessed at baseline, during tsd, and after one night of sleep recovery. biomarkers of endothelial activation, inflammation, and hormones will bemeasured from morning blood samples at 07:00


Eligibility criteria:
inclusion criteria: * healthy * men * 18 - 35 yrs exclusion criteria: * consumming 400 mg of caffeine per day, * body mass index (bmi) greater than 30 kg/m², * taking medication. * excessive daytime somnolence (epworth sleepiness scale \>9) * sleep complaints (pittsburgh sleep quality index \>5) * inability to be considered as an intermediate chronotype on the horne and ostberg questionnaire (score \ 69) * traines subject (ricci gagnon questionnaire \>35)

Keywords: exercise training endothelial function
effect of sulfur thermal water on circulating h2s levels and markers of bone metabolism in osteopenic subjects.

Conditions: Hydrogen Sulfide; Osteoporosis

Summary: the aim of the study is to investigate whether inhalation treatment with high-sulfide waters from some spas (referred to as "thermal waters"), performed for 12 consecutive days, is able to change circulating h2s levels and alter bone metabolism. identifying a clear correlation between circulating levels of h2s and sulfur water administration, as well as a potential anabolic effect on bone, would set the stage for new studies that could have important clinical implications for promoting health and preventing osteoporosis


Eligibility criteria:
inclusion criteria: * post-menopausal women with a diagnosis of osteopenia exclusion criteria: * concurrent muscoloskeletal conditions or chronic pharmacological treatment interfering with bone metabolism
does psychoeducation improve the pain relief derived from a brief intervention

Conditions: Pain; Acute Pain

Summary: this project is a single-site, five-arm, randomized controlled trial investigating whether providing patients in an orthopedic clinic waiting room psychoeducation about mindfulness impacts the degree of pain relief they experience during a mindfulness-based intervention.


Eligibility criteria:
inclusion criteria: * receiving pain treatment at tallahassee orthopedic center * understanding english instructions fluently * being 18 years of age or older exclusion criteria: * unable to consent because of physical or mental incapacity.