Kornimate/medical-research-clean huggingface dataset:
modified intraocular lens to reduce eye inflammation after cataract surgery in uveitis patients

Conditions: Cataracts

Summary: this study will test the effectiveness of an intraocular lens treated with heparin in reducing or preventing inflammation after cataract surgery in patients with uveitis. patients with uveitis (inflammatory eye disease) often develop cataracts (clouding of the lens of the eye) that can impair eyesight. cataracts can be removed surgically, and this is usually done when poor vision interferes with adequate daily functioning, or when the lens becomes too cloudy to evaluate the level of eye inflammation in uveitis-information needed to adjust medication dosages. after surgery, vision is corrected with special eyeglasses, contact lenses, or intraocular lenses (iol). iols are small, plastic artificial lenses permanently placed inside the eye. patients with uveitis who require cataract surgery and whose eye inflammation has been controlled by medicine for at least 3 months may be eligible for this study. those enrolled in the study will be randomly assigned to one of two treatment groups: one group will have a standard iol implanted during cataract surgery; the other will receive a heparin-treated iol. before surgery, patients will undergo standard preoperative tests, including chest x-ray, electrocardiogram, blood tests and urinalysis, as well as an eye examination that includes photography of the cornea, iris and retina. additional tests and examinations to be done at the start of the study and at periodic follow-up visits for about 1 year may include: fluorescein angiography to evaluate the blood vessels of the retina; specular microscopy to examine the surface of the iol; cell and flare measurements to evaluate inflammation, and ultrasound to examine the back of the eye.

the purpose of this project is to evaluate the ability of a heparin-surface modified intraocular lens to reduce the incidence and severity of post-operative inflammation in patients with uveitis undergoing extracapsular cataract surgery. patients who have a history of uveitis and have been in remission on steroids and/or cyclosporine or cytotoxic agents for at least three months will be considered for this study. they will be randomized in a masked fashion to either a surface-modified lens or to a non-modified lens of similar design. the intraocular inflammation will be assessed using standardized clinical criteria, and by a laser cell flare meter at those sites using this equipment. the presence of inflammatory cells on the lens surface will be assessed using specular micrography. in an initial period, the study will only be carried out in the clinical center of the national eye institute (nei) at the national institutes of health (nih). however, in order to complete the study in a reasonable period of time, it may be expanded to include several outside centers.

Eligibility criteria:
follow-up only.

Keywords: cell/flare meter heparin coating inflammation laser cell flare photometry multicentric polymethylmetacrylate specular micrography specular microscopy
telemedicine in total hip arthroplasty and total knee arthroplasty

Conditions: Knee Osteoarthritis; Hip Osteoarthritis

Summary: the objective of this study is to evaluate patient perspective on telemedicine used in 3 week post operative visits for knee and hip arthroplasty. it is hypothesized that patient satisfaction with telemedicine follow-up is equal to patient satisfaction with in-office followup. patient satisfaction will be assessed at the 3-week and 9-week post-operative timepoints.

in 2014 there were 370,770 total hip replacements and 680,150 total knee replacements performed in the united states. as the elderly proportion of the population continues to grow, it is estimated that the number of total hip arthroplasty will grow by 71 percent and total knee arthroplasty will grow by 85 percent by the year 2030 (sloan, m the journal of bone and joint surgery 2018). as these numbers continue to rise, health care delivery must evolve into a more efficient, cost effective system without compromising the quality of the care delivered. telemedicine involves using electronic communications and software to provide clinical services to patients in place of an in-person visit. benefits of telemedicine include avoiding unnecessary trips to hospitals, saving time, and reducing the number of working days missed (asiri, a acta inform med 2018). used in general surgery followup care, anonymous survey responses demonstrated a high degree of satisfaction with 85% expressing a desire to utilize telemedicine for followup care in the future (nikolian, v annals of surgery 2018). postoperative telemedicine has been studied in many specialties, but literature exploring its use in orthopedics has been scant.

Eligibility criteria:
inclusion criteria: there will be two arms of this study, knee and hip patients. * knee: all adult patients over the age of 18 scheduled for a primary total knee arthroplasty will be eligible for the inclusion in the study. * hips: all adult patients over the age of 18 scheduled for a primary total hip arthroplasty will be eligible for the inclusion in the study. exclusion criteria: * lack of access to a telephone * history of wound complications * venous thromboembolism (deep vein thrombosis and/or pulmonary embolism), * significant cardiac history (myocardial infarction, angina, stroke, lower limb ischemia) * subject with any condition (including cognitive impairment) that, in the opinion of the investigator, might interfere with the evaluation of the study objectives.
patients with ocular neuropathic pain: description of pain and impact on their quality of life

Conditions: Dry Eye Syndromes; Neuralgia; Pain; Quality of Life

Summary: some patients with dry eye may have severe disabling neuropathic pain. they describe spontaneous pain, dysesthesia, hyperalgesia or even allodynia. it is classical to note an important discordance between the high intensity of the symptoms and the poverty of the clinical signs. these pains are often unrecognized and therefore often not sufficiently treated. a significant impact on patient's quality of life may occur. the concept of ocular neuropathic pain being relatively recent, few studies have focused on the subject at present. our study aims to shed light on these pains in patients consulting for dry eyes at the ophthalmological foundation a. de rothschild. the objective of our study is to describe precisely the characteristics of neuropathic eye pain and the visual, general and psychological repercussions in these patients.


Eligibility criteria:
inclusion criteria: * patient aged 18 years or older, * presenting at least one of the following symptoms: spontaneous pain, burning sensation in eye, dysesthesia, allodynia, hyperalgesia * french language-skills exclusion criteria: * severe corneal or palpebral damage explaining current pain
a clinical study for the effect of 4th generation poly amidoamine dendrimer on post-bleaching hypersensitivity and shade stability

Conditions: Tooth Hypersensitivity

Summary: this study assessed the impact of four desensitizing agents on both color stability and dental sensitivity following a bleaching procedure, spanning from the 24-hour to the 1-year follow-up assessment periods.

dental bleaching is a temporary treatment with potential adverse effects on dental sensitivity post-procedure. therefore, the study aimed to evaluate dental color stability and sensitivity over a one-year period following bleaching, utilizing one of four desensitizing agents: pamam, mi paste plus, hydroxyapatite and f (reminpro), and ultra ez. the selection of the desensitizing agent was based on a predetermined randomization sequence generated in microsoft excel. color stability was objectively assessed through spectrophotometric analysis, while subjective evaluation was conducted using the vita classic shade guide by two external observers not involved in the procedure. dental sensitivity levels were tracked at various intervals using a visual analogue scale. baseline measurements for both sensitivity and color stability were taken before the bleaching procedure, with subsequent evaluations at 24 hours, 3 days, 1 week, 1 month, 3 months, 6 months, 9 months, and 1 year post-bleaching. the study involved 60 patients from ain shams university seeking dental whitening treatment, divided into four groups based on the randomization sequence.

Eligibility criteria:
inclusion criteria: male and female patients will be selected according to the following inclusion criteria: * participants should have their entire upper and lower teeth, from right first premolar to left first premolar, present and sound, without restorations or periodontal disease. * teeth have never been bleached before. * the participants are required to have low-caries index. * teeth should have a vita-color shade of a2 or darker. * cooperative behavior patient and medically free. * patient ages between 18 to 40 years old. exclusion criteria: * serious medically compromised patients. * smoking, alcoholism. * hypersensitivity to the agents used in the study. * lactated, pregnant patients. * patients have serious oral diseases, as acute necrotizing gingivitis, acute gingiva stomatitis, or undergoing orthodontic treatment. * patients with dental enamel cracks. * patients who had previous bleaching treatments

Keywords: dental bleaching shade stability
does caffeine reduce postoperative bowel paralysis after elective colectomy?

Conditions: Postoperative Ileus; Laparoscopic Colectomy Without Stoma Formation; Colorectal Neoplasm; Diverticulitis

Summary: postoperative bowel paralysis is common after abdominal operations, including colectomy. as a result, hospitalization may be prolonged leading to increased cost. a recent randomized controlled trial from the university of heidelberg showed that consumption of regular black coffee after colectomy is safe and associated with a significantly faster resumption of intestinal motility (müller 2012). the mechanism how coffee stimulates intestinal motility is unknown but caffeine seems to be the most likely stimulating agent. thus, this trial addresses the question: does caffeine reduce postoperative bowel paralysis after elective laparoscopic colectomy? patients after laparoscopic colectomy will receive either 100 mg caffeine, 200 mg caffeine, or 250mg corn starch (placebo) 3 times daily in identically looking gelatin capsules. the study is a randomized, controlled trial, with blinding of physicians, patients and nursing stuff (evaluating the endpoints). primary endpoint will be the time to first bowel movement.


Eligibility criteria:
inclusion criteria: * patients scheduled for elective laparoscopic colectomy (right or left hemicolectomy, segmental resection, extended hemicolectomy, sigmoid resection, upper rectum (anastomosis higher than 7 cm ab ano)) * there will be no upper age limit. if elderly patients are considered fit for surgery, they will be included in the study. * informed consent * application of epidural analgesia exclusion criteria: * participation in another concurrent interventional trial * need for a stoma (colostomy or ileostomy) or reversal of a stoma, if the patient had a complete bowel obstruction * known hypersensitivity or allergy to caffeine/coffee * expected lack of compliance * american society of anesthesiologists (asa) physical status score of iv or v * impaired mental state or language problems * alcoholism or drug abuse * previous extensive abdominal surgery * inflammatory bowel disease * clinically significant cardiac arrhythmia * cardiac insufficiency * pregnancy, lactation, or childbearing potential without using adequate contraception * intake of opioid analgesics, or steroids \>5mg/d for ≥7 days before surgery * under anti-depressive medication * liver cirrhosis or compromised liver function (meld score \>15) * emergency procedure

Keywords: colectomy laparoscopy caffeine
saline versus albumin fluid for extracorporeal removal with slow low efficiency dialysis feasibility study

Conditions: Renal Replacement Therapy; Acute Kidney Injury; Hypotension

Summary: objective: the primary aim of this 60 patient feasibility trial is to determine if, for critically ill patients treated with sled for aki, randomization to receive albumin (25%) boluses versus normal saline placebo boluses is feasible, with respect to the recruitment rate, blinding and adherence to the protocol.

background: intravenous albumin (25%) boluses are frequently given to critically ill patients during slow low-efficiency dialysis (sled) treatments for acute kidney injury (aki). the intention of giving albumin during sled is to stabilize the blood pressure to permit more aggressive overall fluid removal with ultrafiltration; however, there is little evidence to support this expensive practice. objective: the primary aim of this feasibility trial is to determine if, for critically ill patients treated with sled for aki, randomization to receive albumin (25%) boluses versus normal saline placebo boluses is feasible, with respect to the recruitment rate, blinding and adherence to the protocol. the results of this feasibility trial will help us to plan and carry out a multicentre pilot trial comparing the efficacy of the interventions in achieving fluid removal in critically ill patients with aki on sled. design: a randomized controlled trial with two parallel arms. setting: the mixed medical-surgical intensive care units of a canadian tertiary care hospital. study population: 60 patients with aki requiring treatment with sled (by definition, kidney disease improving global outcomes (kdigo) stage 3 aki). intervention: participants will be randomized to receive either albumin (25%) boluses or normal saline placebo boluses during their sled treatments.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 yrs; 2. aki treated with sled (stage 3 aki per kidney disease improving global outcomes (kdigo) aki guidelines48). exclusion criteria: 1. sled initiated for non aki-related indication (i.e. concurrent intoxication; treatment of hypothermia); 2. receiving chronic dialysis treatments; 3. history of allergic reaction to albumin; 4. pregnancy.

Keywords: albumin normal saline dialysis intensive care unit
exercise in treatment resistant depression (trd): a feasibility study

Conditions: Treatment Resistant Depression

Summary: the objective of this study is to determine the effects of adjunct exercise in treatment resistant depression. the central hypothesis for the research is that adjunct exercise with usual care in treatment resistant depression (trd) will have significant effects in improving the psychiatric symptoms in comparison to usual care alone.

participants with treatment resistant depression will be recruited to participate in a 12-week clinical trial on the effects of adjunct moderate-intensity exercise versus usual care. primary outcome measure will be reduction in baseline scores on hamilton depression rating scale (17 item). secondary outcome measure will include reduction in baseline scores of clinical global impression severity, pittsburgh sleep quality index global score, scores on beck depression inventory, and improvement in actigraphic sleep.

Eligibility criteria:
inclusion criteria: * being sedentary (exercising less than 3 times/week for \> 20 minutes at moderate/vigorous intensity for each bout) * ability to come for supervised exercises up to 5 days/week. * on stable doses of medication or psychotherapy (within last 1 month) for underlying depression and willingness to continue on stable dose or therapy schedule during active phase of study participation, with the exception of during acute exacerbation of symptoms of psychiatric illness. * being able to read, understand, and provide written informed consent. exclusion criteria: * dsm-iv tr axis i diagnosis of bipolar disorder, schizophrenia or schizophrenia spectrum disorder, or substance or alcohol abuse/dependence disorder (except nicotine dependence) in the past 12 months. patients with current primary anxiety disorder will also be excluded. * behavioral or personality disturbances, which may significantly interfere with study participation. * evidence of acute suicidal risk. * medical contraindication for physical exercise (significant orthopedic or cardiopulmonary disorder) that would prevent regular aerobic exercise. the american college of sports medicine criteria for risk stratification will be used and where indicated medical clearance for exercise will be obtained through the subject's primary care physician. * pregnancy.

Keywords: treatment resistant depression exercise
basic life support by children

Conditions: Cardiopulmonary Arrest With Successful Resuscitation; Child, Only

Summary: a controlled clinical trial will be performed. school children from the age of 10 to 11 will be selected to learn basic life support (bls) in a primary school of zaragoza. one of the groups will learn bls in two consecutive years and the other group will learn bls only the first year. the investigators think that the knowledge will be better in the group that receives two interventions.

a controlled clinical trial will be performed. 72 participants between 10 and 11 years old will be selected and randomized to participate. control group and experimental group will enrolled 36 participants each one. control group will receive bls training once. experimental group will receive bls training in two consecutive years. previous and after training a test will be performed.

Eligibility criteria:
inclusion criteria: * children from 10 to 12 years old that are attending to the selected school at the moment of the intervention * children with signed consent given by parents at the moment of the intervention exclusion criteria: * children not attending all the theorical and practical interventions * children not completing all test. * children with learning disabilities
choice of diction's effect

Conditions: Communication; Advance Directives; Decision Making; Cardiopulmonary Resuscitation

Summary: the purpose of the research is to determine how the language used when discussing preferences about cardiopulmonary resuscitation (cpr) affects decisions regarding this (code status)

most americans express a preference for dying at home naturally and surrounded by loved ones. however, many also believe that cardiopulmonary resuscitation (cpr) is more effective than it is, and want to have cpr even when the chances for a good outcome is poor. among other reasons, the alternative term (do not resuscitate, or dnr) has been shown in the literature to be associated by patients with passive, sub-optimal, and low quality care. this study will attempt to determine patient preference for the "no cpr" term on patients admitted to the hospital using alternate phrasing. during admission to the medical teaching service, patients over the age of 65 who are able to consent and who are not critically ill/unstable will be approached. after checking brief background questions (such as if they ever had discussions like these before), they will be randomized into two groups and asked code status using one of the two phrases. this question will determine the patient's "code status;" asking for this is a routine part of hospitalized care that is required by law (the exact terminology is left to the care team). after determining the patient's code status, they will be asked how satisfied they were with the decision; the investigator will be asked if they agree with the decision separately. demographic and clinical information will be collected. six months later, the patient will be contacted again; at this time, they will be asked about recent life and health changes. finally, they will be asked their code status one more time. this will conclude the participant's involvement in the study

Eligibility criteria:
inclusion criteria: * 65 or older * english-fluency in reading and speaking * capacity to consent exclusion criteria: * unstable psychiatric illness * unstable/critically ill patients requiring icu-level care * active substance abuse

Keywords: older adult allow a natural death do not resuscitate resuscitation decisions
prediction and validation of unipolar depression with psychosocial-somatic markers in a naturalistic cohort recruited in an outpatient setting

Conditions: Depressive Disorder; Depression; Depressive Symptoms; Depressive Episode; Major Depressive Disorder

Summary: the pokal-psy project is a study that monitors participants for five years. the goal of the study is to identify distinguishable subtypes of depression on the basis of biomarkers and to gain insight into their prognostic significance.


Eligibility criteria:
inclusion criteria: * (phq\>8) if depressed * subjects of any sex aged between 18-70 * sufficient ability to speak and understand the german language * ability to understand and sign the informed consent form exclusion criteria: * cognitive impairment that interferes with reliable completion of questionnaires or answering questions * presence of manic episode, bipolar disorder, schizophrenia or schizoaffective disorder (as well as other diseases in the f2 domain in the icd), active eating disorder, active drug or alcohol dependence syndrome * presence of uncontrolled systemic disease (e.g. autoimmune disease), uncontrolles somatic (other than metabolic or cardiovascular)/ neurologic diseases, current or recent (last month) physical trauma * patient with acute suicidal ideation * known deficiency of alpha-1-antitrypsin * pregnant or lactating women
study of the influence of sleep on hemodynamic parameters in patients with sleep disorders

Conditions: Hypertension; Sleep; Insomnia

Summary: several epidemiological studies in large cohorts suggest a strong association between sleep duration, complaint of insomnia and risk of hypertension.these findings suggest an important role of sleep quality in development of hypertension. principal limitations of these studies are the cross-sectional study design, self-report sleep duration and poor measurement of blood pressure. the investigators propose to study an insomniac population with complete evaluation of quality and quantity of sleep, associated to complete hemodynamic measurement of hypertension.

hypertension and sleep disorders is a cross sectional study realised in an adult cohort with chronic complain of insomnia. in our study, sleep duration is evaluated by complete evaluation of quality and quantity of sleep: one night psg, associated with sleep agenda during 3 weeks, actigraphy, and several sleep questionnaires. we join to this sleep evaluation, a complete hemodynamic evaluation with: path way velocity and central bp obtained by tonometry, ambulatory bp measurement (abbm), and self- bp measurement. the primary objective of this epidemiological study is to show an increase risk of hypertension when sleep duration is less than 7 hours, with objective measurement of sleep duration and hypertension. secondary objectives are to evaluate role of complain of insomnia in the risk of hypertension, and to determine cardiovascular risk in insomnia with hemodynamic explorations.

Eligibility criteria:
inclusion criteria: * adult with insomnia (6 months or more) exclusion criteria: * sleep disorders with obstructive apnea

Keywords: hypertension sleep insomnia