Kornimate/medical-research-clean huggingface dataset:
association between neck pain and quality of sleep

Conditions: Chronic Neck Pain; Disability

Summary: a prospective study to assess the association between the change in quality of sleep and the change in intensity of pain in spanish patients seen for subacute or chronic neck pain. the objective is to determine the prevalence of sleep alterations, the association between quality of sleep and intensity of pain, degree of disability, intensity of catastrophizing and depression.


Eligibility criteria:
inclusion criteria: * patients with nonspecific neck pain of more than 14 days duration * seen in health centers participating in the study * patients who accept to participate and sign the consent form * without age limits and regardless of gender exclusion criteria: * inability to complete the questionnaires (illiteracy, dementia) * inflammatory rheumatologic disease, fibromyalgia, cancer in last 5 years

Keywords: quality of sleep neck pain disability catastrophizing depression
register of treatment of unprotected left main coronary artery stenosis in andalucía

Conditions: Unprotected Left Main Coronary Artery Stenosis

Summary: register of treatment of unprotected left main coronary artery stenosis in andalucia (retrato).


Eligibility criteria:
inclusion criteria: * new diagnosed of unprotected left main coronary artery stenosis (lesion ≥50%) * have signed informed consent exclusion criteria: * participating in other research protocol * inability to follow a monitoring

Keywords: coronary stent procedure (csp coronary-artery bypass grafting (cabg)
triaging patients with musculoskeletal disorders directly to physiotherapists at primary health care clinics.

Conditions: Musculoskeletal Disorders

Summary: the purpose of this study is to determine whether initial triaging to physiotherapists of patients with musculoskeletal disorders who seek health care from primary care clinics affects the patients health and/or health care utilization differently than initial consultation with a general practitioner.


Eligibility criteria:
inclusion criteria: * seeking primary care clinic for musculoskeletal disorder * age 16-67 years * speaks enough swedish or english to understand the patient information and complete the questionnaires * triage nurse judges it suitable to triage participant to physiotherapist exclusion criteria: * has received treatment at the clinic by physician or physiotherapist during the preceding month for the same problem * seeking for chronic musculoskeletal disorder with unchanged symptoms the latest 3 months and for which the patient has already tried physiotherapy * seeking for help with medical aids other than crutches * is in need of home care * has been included in the study earlier
r-21 colorectal cancer screening (crcs) pilot trial

Conditions: Colorectal Neoplasms

Summary: the goal of this study is to test patient education program for decision making about colorectal cancer (crc) screening in community health centers.

baseline visit: if you agree to take part in this study, you will complete a questionnaire that asks demographic questions (such as your age and sex) and questions about colorectal cancer. it should take about 10-15 minutes to complete. you will be randomly assigned (as in the flip of a coin) to 1 of 2 groups. if you are in group 1, you will view a colorectal cancer program. if you are in group 2, you watch a program on essential hypertension. you will watch the program on a laptop in the clinic. the program is about 30 minutes long. after you watch the program, you will complete a questionnaire that asks what you thought about the program and some questions about understanding medical information. it should take about 5-10 minutes to complete the questionnaire. you will be called 1-3 weeks after your baseline visit to complete a questionnaire by phone. the call should last about 20-25 minutes. you will be asked if you discussed colorectal cancer screening tests with your doctor, your preferences for colorectal cancer screening tests, and if any colorectal cancer screening tests were ordered. at month 3, your medical record will be reviewed by the study staff. length of study: you will be off study after your medical record is reviewed at month 3. this is an investigational study. up to 180 participants (90 hispanic and 90 african-american) will take part in this study. all participants will be enrolled from the harris county hospital district and kelsey-seybold outpatient clinics.

Eligibility criteria:
inclusion criteria: 1. male or female patients 2. 49 -75 years of age 3. english-speaking african american or spanish-speaking hispanic patients (upon approval of spanish language arm) exclusion criteria: 1. history of colorectal cancer 2. history of polyps 3. any inflammatory bowel disease (ibd), e.g. crohn's disease or ulcerative colitis 4. family history of colorectal cancer in a first degree relative 5. had fecal occult blood test (fobt) in the past year, flexible sigmoidoscopy in the past 5 years or colonoscopy in the past 10 years

Keywords: colorectal neoplasms promoting health literacy patient education program colorectal cancer screening crcs patient decision aid ptda video questionnaires surveys
preoperative and intraoperative quantification of axillary tumoral load

Conditions: Breast Cancer

Summary: at present, patients diagnosed of a breast cancer with infiltration of the axillary lymph-nodes are submitted to axillary lymph-node dissection (alnd). the sentinel node (sn) technique is not indicated when a lymph-node biopsy or cytology is positive, nor when the surgical treatment is upfront neither when a neoadjuvant systemic therapy is indicated. the reason for not performing sn is that patients diagnosed of an infiltrated axilla though ultrasound-guided biopsy or cytology tend to have a higher tumoral load than those diagnosed after a sentinel biopsy. furthermore, even if these patients are submitted to a neoadjuvant systemic treatment and the axillary clinical exploration is negative after the treatment, different studies showed that the sn false negative rate is unacceptably high. despite these facts, a high proportion of patients with a positive axilla at diagnosis and submitted to level i and ii axillary lymph node dissection show few lymph nodes infiltrated in the pathological study, frequently four or less neoplastic nodes. new methods of detecting these patients with limited infiltrated nodes should be developed and new approaches to axillary surgery (i.e., partial resection) should be offered. to date, the only information expected to get after an axillary imaging is performed is if the axilla is infiltrated or not. no information about the tumoral load is demanded. in the other hand, level i and ii alnd is performed according to established anatomic limits, without selecting the nodes to be excised neither identifying the ones infiltrated for a directed excision. the aim of the study is to evaluate the ability of a specified and reproducible imaging protocol for distinguishing patients with a high axillary tumoral load from the ones with a low tumoral load. at the same time, as the initial nodes receiving lymph drainage should be the ones commonly affected, identifying these nodes injecting diluted methylene blue in the retroareolar parenchyma and studying their tumoral load could help selecting patients with high from those with low axillary tumoral load. evaluation of both steps (that is, first the imaging protocol followed by the methylene blue protocol), could eventually help to distinguish which patients should be submitted to a classical level i and ii alnd and which ones can be spared from excising the lymph nodes not stained by the methylene blue.


Eligibility criteria:
inclusion criteria: * breast cancer patients with infiltrated axillary lymph nodes ct1-4 cn1 * older than 18 years old * able to understand and accept the protocol procedure and to sign an informed consent form in accordance with national legislation. exclusion criteria: * breast cancer patients in whom no information about axillary lymph nodes status (cytology or biopsy) is available. * patients younger than 18 years old. * psychiatric disease * difficulties to understand spanish.
using short message service as a means of clinical engagement in early psychosis

Conditions: Psychotic Disorders

Summary: engagement with clinical services for youth with early psychosis represents a significant challenge, with up to 40% of patients dropping out of treatment in the first year. this has been linked to worse illness outcomes and represents a significant barrier to recovery for these patients. this study aims to evaluate the efficacy of short message service (sms) as a means of improving clinical engagement in early-episode psychosis populations by bridging contact between appointments with weekly check-ins/reminders. these weekly check-ins during the first year of treatment will serve as an additional opportunity to reach out to patients and give them a chance to do the same with their care teams, with patient responses triggering clinician follow-up if necessary.


Eligibility criteria:
inclusion criteria: * between the ages of 16-29 * a diagnosis of an affective or non-affective psychotic disorder (i.e., bipolar or major depressive disorders with psychotic features, schizophrenia spectrum disorders, other specified psychotic disorders, substance induced psychosis and attenuated psychotic syndrome) * eligible for follow-up within the slaight family centre for youth in transition early intervention service * within the first 6 months of treatment exclusion criteria: * involved in another intervention study * do not have a personal cell phone number

Keywords: sms text messaging clinical engagement
effect of microneedling, bimatoprost and excimer in vitiligo treatment

Conditions: Vitiligo

Summary: the purpose of this research is to treat vitiligo with a topical pgf2α, microneedling and excimer laser. the goal is to have greater repigmentation than the standard of care (excimer) after 12 weeks of treatment. the study is a pilot, split study meaning the patient will receive one experimental and one standard of care treatment on symmetric lesions of similar location, geometrics and size. enrolled subjects will present biweekly to clinic on the same two days for twelve weeks. one lesion will be treated with microneedling, topical pgf2α and calibrated excimer laser, while the parallel lesion will be excimer laser alone. physical exam, photographs, and a review of of the subjects medical records will occur in the study. changes in size, appearance, and adverse events will be monitored throughout the study. the patient will also agree to close up photographs of their lesions throughout the study. the possible benefit of joining this study is that the treatment received may be more effective than the other study treatment or then other available treatments for vitiligo, although this cannot be guaranteed.


Eligibility criteria:
inclusion criteria: * all patients 18 years and older with the diagnosis of vitiligo. exclusion criteria: * female patients currently pregnant or lactating * female patients with plans to come pregnant during the next 3 months * allergic reactions to topical or oral prostaglandins * uncontrolled skin disease * history of glaucoma * concomitant disease or therapy that interferes with the diagnosis that might interfere with vitiligo diagnosis sand evaluation. * patients currently using other treatments for vitiligo, such as topical steroids, calcineurin inhibitors, and vitamin d analogs within 2 weeks of study initiation * inability or unwillingness of subject or legal guardian/representative to give
the frequency of positive challenge test to penicillin in children suspected to have allergy to penicillin

Conditions: Penicillin Allergy

Summary: the incidence of reactions during penicillin challenge tests among children with suspected penicillin allergy

children who are suspected to have penicillin allergy due to a suspected allergic reaction during penicillin treatment are sent for allergy investigation to role out allergy. patients go through penicillin test and if negative are challenged by oral administration under medical observation. the investigators would like to check the incidence among our pediatric pediatric patients.

Eligibility criteria:
inclusion criteria: * children older then 6 month with suspected penicillin allergy exclusion criteria: * children under 6 month old
the impact of targeted temperature management duration on thrombin function in cardiac arrest patients

Conditions: Targeted Temperature Management; Cardiac Arrest; Thrombin Function; Treatment Duration

Summary: this study will be a single-center, prospective, randomized controlled trial with an estimated sample size of 64 patients. eligible patients will be randomly assigned in a 1:1 ratio to receive ttm for either 24 hours or 72 hours. the primary outcome measure will be the changes in thrombin function indices at various time points during ttm treatment in both groups. the secondary endpoints of the study include additional coagulation function indicators, the incidence of bleeding-related events between the two groups, the amount of blood products used, the incidence of thrombotic events, and the cpc scores at 28 days and 6 months for both groups.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 80 years; 2. glasgow coma scale score of less than 8 upon admission; 3. patients resuscitated after out-of-hospital cardiac arrest; and (4) patient or their legal representative has signed the informed consent form. exclusion criteria: 1. cardiac arrest caused by irreversible factors such as trauma or poisoning; 2. cardiac arrest due to terminal conditions like advanced cancer; 3. uncorrected persistent cardiogenic shock, defined as a systolic blood pressure below 90 mmhg despite treatment with fluid resuscitation, vasopressors, and inotropic agents; 4. pre-existing cerebrovascular disease or ct-confirmed intracerebral hemorrhage upon admission; 5. pre-arrest cerebral performance category (cpc) score between 3 and 5; 6. bradycardia or sick sinus syndrome following the return of spontaneous circulation; 7. pre-existing coagulation disorders or severe bleeding tendencies; 8. pregnant or breastfeeding women, or women of childbearing age with elevated serum hcg levels; 9. presence of treatment limitations (such as refusal by the patient or legal representative to undergo advanced life support, including mechanical ventilation, chest compressions, or targeted temperature management); 10. determination by the principal investigator that the patient is unsuitable for the trial.
multiple ascending dose study of hm12470 in type 1 and type 2 diabetes mellitus

Conditions: Type1 Diabetes Mellitus; Type2 Diabetes Mellitus

Summary: this is a phase 1 multiple ascending dose (mad) study, conducted in subjects with type 1 and type 2 diabetes mellitus


Eligibility criteria:
inclusion criteria: * t1dm or t2dm * female subjects must be non-pregnant and non-lactating exclusion criteria: * pregnant or lactating women * participation in an investigational study within 30 days prior to dosing
short message system (sms) monitoring intended for the suicidal patients

Conditions: Patients Having Realized a Suicide Attempt

Summary: the study wants to prove that sms monitoring reduced the number of suicide attempts in six months according to the beginning of its implementation in the group of the patients benefiting sms compared with the group of patients benefiting from the usual care.


Eligibility criteria:
inclusion criteria: * written informed consent * surviving a suicide attempt * leaving directly the emergency department or hospitalized less than 7 days * being able to be joined by telephone mobile exclusion criteria: * under guardianship * patient who are not able to provide a consent

Keywords: suicide attempt, sms monitoring, recurrence, phone, prevention control, tertiary healthcare
rural disparities in pediatric obesity: the iamhealthy intervention

Conditions: Weight Loss

Summary: the purpose of this study is to learn if providing a family-based group program using mobile health technology (iamhealthy healthy lifestyles program) is effective at improving child weight, nutrition, and physical activity.

this is a cluster-randomized study that will test the iamhealthy healthy lifestyles program versus a standard approach to weight loss in kids current in 2nd thru 4th grade. the iamhealthy healthy lifestyles program utilizes mobile tools to deliver the weight loss program to kids and families in rural settings. this study will include kids from schools in rural cities/counties, and their parents, and they will be randomly assigned to a group by their school. the iamhealthy healthy lifestyles program is a rurally tailored telemedicine intervention. it delivers behavioral, nutritional, and physical activity topics for kids and their families. the total length of the intervention will be about 8 months, which coincides with the length of a typical school year.

Eligibility criteria:
inclusion criteria: * family lives in a rural area (city and/or county population less than 20,000) * child body mass index (bmi) \>85th and \<99th percentile * child in 2nd thru 4th grade * child and parent speak english * family is available at times intervention is offered exclusion criteria: * child has physical limitation or receives an injury which significantly limits physical mobility * child has significant medical issue * child and parents have significant developmental delay or cognitive impairment * child has a sibling who has already enrolled in the program * family moves to a non-participating school
gleevec combined with camptosar plus paraplatin in previously untreated extensive stage small cell lung cancer

Conditions: Lung Cancer

Summary: this study will evaluate combination chemotherapy for patients with extensive stage small cell lung cancer combined with the potentially useful growth inhibiting effects of gleevec.

upon determination of eligibility, all patients will be receive: * irinotecan + carboplatin + imatinib

Eligibility criteria:
inclusion criteria: to be included in this study, you must meet the following criteria: * small cell lung cancer with extensive stage disease confirmed by biopsy * measurable or evaluable disease * ability to perform activities of daily living with minimal assistance * adequate bone marrow, liver and kidney * no active brain metastasis. * no previous chemotherapy or radiation therapy * give written informed consent. exclusion criteria: you cannot participate in this study if any of the following apply to you: * limited stage disease (includes ia, ib, iia, iib, and iiia) * active brain metastasis * age \< 18 years old * history of a prior malignancy within three years * women pregnant or lactating. please note: there are additional inclusion/exclusion criteria. the study center will determine if you meet all of the criteria. if you do not qualify for the trial, study personnel will explain the reasons. if you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
monitoring of immune and microbial reconstitution in (hct) and novel immunotherapies

Conditions: Immune and Microbial Reconstitution; Systemic Viral Infection; Acute-graft-versus-host Disease; Chronic Graft-versus-host-disease; Recurrent Malignancy; Cytokine Release Syndrome; Allogenic Related Donors; Cell Therapy/Immunotherapy Patients

Summary: this protocol serves as a mechanism to collect, store, and distribute bodily fluid and tissue samples obtained from hematopoietic cell transplant (hct) or novel immunotherapy patients and their donors at the masonic cancer center in order to conduct correlative studies of the immune system, microbiota, and their interactions. fluid (including but not limited to, blood, urine, saliva, cerebrospinal fluid, bronchoalveolar lavage fluid) sample log-in, processing, relabeling, and storage is performed by the masonic cancer center (mcc) translational therapy lab (ttl).


Eligibility criteria:
inclusion criteria: * patients planning to undergo hct or other cellular therapy/immunotherapy * allogeneic related donors * aged 0-80 * willing and able to sign voluntary written consent exclusion criteria: * patients whose medical record indicates that they have opted out of research
acceptability, feasibility, and effectiveness of a four-week feeling tone mindfulness course

Conditions: Mindfulness; Depression; Anxiety; Stress; Wellbeing; Self-compassion

Summary: this is an academic research study aiming to explore the acceptability, feasibility, and effectiveness of a four-week feeling tone mindfulness course on equanimity, mindfulness, self-compassion, and mental health outcomes.

the four-week feeling tone mindfulness course is an adapted version of a mindfulness intervention program recently developed by professor mark williams and colleagues. this study aims to explore the acceptability, feasibility, and effectiveness of a four-week feeling tone mindfulness course on equanimity, mindfulness, self-compassion, and mental health outcomes (e.g., depression, anxiety, stress, wellbeing) in a hong kong population.

Eligibility criteria:
inclusion criteria: * aged 18 or above * speak and understand cantonese as well as written chinese to a level where the participant can fully take part in the course without the need for translation support * have means to access online teleconferencing meeting software (e.g., zoom), online surveys, online intervention materials, and short message service (sms) or whatsapp messenger exclusion criteria: * moderately severe or severe depressive or anxiety symptoms * diagnosed with bipolar disorder or bipolar affective disorder (type i or type ii) or ever experienced a manic/hypomanic episode * diagnosed with schizophrenia/ psychosis or ever experienced a psychotic episode * diagnosed with dementia/ neurocognitive disorders/ neurological disorders * diagnosed with intellectual disability * diagnosed with other neurodevelopmental disorders * experience of a traumatic event that is currently affecting the potential participants * recent bereavement, major loss, or stressful life events * suicidal * alcohol or drug abuse * currently experiencing other mental or physical health condition, or life condition that might affect potential participants' participation in the course * prior experience of taking part in the feeling tone intervention as a course participant