Kornimate/medical-research-clean huggingface dataset:
biodex sit2stand for individuals with cardiac disease

Conditions: Coronary Artery Disease; Frail Elderly Syndrome; Heart Failure

Summary: patients with cardiac disease have been shown to have deficits in activities such as standing up from a chair. the biodex sit2stand trainer is a new device meant to improve sit to stand performance by providing a lifting force through the seat to help the individual stand. the amount of lift can be graded to help improve leg strength, endurance, and function over time. the device has the potential to be a form of training for those in cardiac rehabilitation who have limitations in standing from a chair.

patients who are diagnosed with cardiovascular disease and enter cardiac rehabilitation present with limitations in activity and restrictions in their abilities to participate in society. even after a standard course of cardiac rehabilitation, some individuals will still present with deficits. one area this is seen is the ability to stand up from a chair. a new device, the biodex sit2stand trainer, has been designed to help improve the standing movement in those with lower extremity weakness. the trainer provides a graded lift or push through the seat to help the participant reach a standing posture. this study will whether a six week training program using the trainer will lead to improvements in strength, function and quality of life for those individuals who have recently completed a cardiac rehabilitation program. this study is a pilot study to help determine the ideal dosage of training and identify any limitations in using the device with this population. based on the results of this pilot work, a larger intervention study will be conducted to examine the effectiveness of the trainer in a cardiac rehabilitation program.

Eligibility criteria:
inclusion criteria: individuals nearing the end of their cardiac rehabilitation program will be asked to participate. inclusion criteria include the following: * completion of a cardiac rehabilitation * ability to walk 50 feet independently with or without an assistive device * inability to stand from a standard chair five times without the use of their arms or unable to complete five sit to stands in less than 15 seconds. * no major cardiac arrhythmias during cardiac rehabilitation sessions. * ability to attend 14 sessions over a 7-8 week period exclusion criteria: * not meeting inclusion criteria

Keywords: cardiac rehabilitation sit to stand function
prevalence of renal failure and risk factors in an unreferred healthy population

Conditions: Healthy

Summary: blood sample is taken for measurement of serum creatinine, cystatin c, clone v haemoglobin, cholesterol, urine acid, glycemia and crp. the medical file is gathered. there will be searched for an association between renal function and cardiovascular risk factors and risk factors by exposition to toxic substantia during work.


Eligibility criteria:
inclusion criteria: * 20-55 years * male and female subjects

Keywords: no specific condition
amantadine to speed awakening after cardiac arrest

Conditions: Coma; Heart Arrest; Anoxia

Summary: this study evaluates if amantadine will increase the rate of awakening in patients resuscitated from cardiac arrest but comatose (not following commands) after their resuscitation. half of the participants will receive amantadine and the other will receive placebo.

amantadine has been used to help patients awaken following traumatic brain injury, but it has not been studied in patients with anoxic brain injury. amantadine is a dopamine agonist and may help with stimulating the brain to awaken. the investigators will randomize subjects who remain comatose 72 hours following resuscitation from cardiac arrest to either amantadine or placebo. they will be treated with either amantadine or placebo for 7 days.

Eligibility criteria:
inclusion criteria: * non traumatic cardiac arrest * age 18 and older * defibrillation and/or chest compressions by healthcare providers * return of spontaneous circulation exclusion criteria: * written do not attempt resuscitation (dnar) reported to providers before randomization * known prisoner or pregnancy * lack of motor response to pain and absent n20 response on somatosensory evoked potentials prior to randomization * initial ct demonstrating brain edema (defined as grey white ratio \<1.2) * presence of malignant pattern on eeg at time of randomization * next of kin unwilling to provide supportive care for at least one week after enrollment * presently using other dopaminergic agent

Keywords: heart arrest resuscitation seizures hypothermia, induced amantadine
enzymatic debridement in burns patients: a comparison to standard of care

Conditions: Burn

Summary: burns represent one of the most severe and dreaded traumas. burned and traumatized tissue is known as eschar. the dead eschar, if not removed, often becomes heavily contaminated and is the source of local and/or systemic infection or sepsis. the local inflammation and infection destroy healthy surrounding tissues and extends the original damage. in order to prevent these complications, and in order to minimize the risk of infection, it is imperative to evaluate the burn and remove all of the offending eschar at the earliest possible opportunity. this removal of dead tissue is termed "debridement". the most direct debridement method for eschar removal is surgery. traditional, conservative non-surgical debridement is a lengthy process which often involves many complications. the objective of this study is to evaluate the safety and enzymatic debriding efficacy of debrase gel dressing (dgd) in hospitalized patients with deep partial thickness and/or full thickness thermal burns and to compare dgd to standard of care (soc).

completed study.

Eligibility criteria:
inclusion criteria: 1. males and females between 4 years to 55 years of age, 2. thermal burns caused by fire/flame, scalds or contact, 3. deep partial thickness (mixed deep dermal) and/or full thickness (3°) burn wounds ≥ 5% and ≤ 30% total body surface area (tbsa); all these wounds must receive study treatment, 4. at least one wound of ≥ 2% tbsa deep partial thickness and/or full thickness burn, 5. total burn wounds ≤ 30% tbsa, 6. signed written informed consent. exclusion criteria: 1. deep partial thickness and/or full thickness facial burn wounds, \> 0.5% tbsa; study treatment of facial burns is not allowed, 2. study treatment of perineal and/or genital burns (a patient with these wounds may be enrolled but the wounds may not be designated as target wounds), 3. circumferential anterior/posterior trunk full thickness fire/flame burns, \> 15% tbsa, (circumferential is defined as encircling ≥ 80% of the trunk circumference.) 4. pre-enrollment escharotomy, 5. heavily contaminated burns or pre-existing infections, 6. signs that may indicate smoke inhalation, 7. general condition of patient would contraindicate surgery, 8. pregnant women (positive pregnancy test) or nursing mothers, 9. poorly controlled diabetes mellitus (hba1c\>9%), 10. cardio-pulmonary disease (mi within 4 weeks prior to injury, pulmonary hypertension, copd or pre-existing oxygen-dependent pulmonary diseases), 11. pre-existing diseases which interfere with circulation (pvd, edema, lymphedema, surgery to the regional lymph nodes, obesity, varicose veins), 12. immediate life threatening conditions (such as immuno-compromising diseases, life threatening trauma, severe pre-existing coagulation disorder, cardiovascular, liver or neoplastic disease),
comparison of outcome of wound closure after thyroid surgery with and without platysma suturing

Conditions: Pain, Acute Postoperative

Summary: comparison of outcome of wound closure after thyroid surgery with and without platysma suturing in terms of wound scar and pain.

this randomized controlled trail was conducted at surgical ward from january 2021 to july 2021. materials and methods total 72 patients (indicated for thyroid surgery) who were fulfilling the inclusion criteria were enrolled. patients were divided randomly into two groups by using lottery method. in group a patients wound closure was done without platysma suturing and in group-b patients wound closure was done with platysma suturing. pain assessment was done with the help of vas after surgery (6, hours, 24 hours, 48 hours). scar assessment was carried out with the help of posas. all this information was noted by the researcher himself and noted on a well-designed questionnaire.

Eligibility criteria:
inclusion criteria: * : both men and women patients in the age range (20-70 years) undergoing primary thyroid surgery were included. exclusion criteria: * patients with disorders of wound healing, diabetes mellitus, pre-operative known malignant condition, history of neck surgery or not willing to participate in the study were excluded.

Keywords: thyroid surgery scar visual analog scale
use of death cafes to prevent burnout in icu healthcare employees

Conditions: Burnout; Burnout, Professional; Burnout, Psychological; Anxiety; Depression

Summary: burnout affects a significant number of healthcare employees and leads to worsened mental health, increased job turnover, and patient safety events. those caring for critically ill patients may be especially susceptible due to high patient mortality, long hours, and regular encounters with traumatic and ethical issues. preliminary studies suggest that debriefing opportunities may reduce burnout through reflection on distressing patient events, enhancement of social support, and interprofessional collaboration. death cafés are a specific form of debriefing that focus on discussing death, dying, loss, and illness. the purpose of this study is to evaluate whether biweekly death cafe group debriefing sessions can prevent burnout in icu physicians and staff.


Eligibility criteria:
inclusion criteria: * physicians, nurses, pharmacists, or therapists working in the intensive care unit and have worked for the full-time equivalent of at least 1 week in the preceding 4 weeks exclusion criteria: * not physicians, nurses, pharmacists, or therapists * have worked less than the full-time equivalent of at least 1 week in the preceding 4 weeks

Keywords: critical care nurses physicians healthcare workers death grief stress, psychological occupational stress behavioral symptoms coping skills clinical trial
comparative effects of motor imagery and mirror therapy versus motor relearning program in subacute stroke patients

Conditions: Stroke

Summary: use of motor imagery, mirror therapy and motor relearning program in rehabilitation of people with stroke is on rise and these are unique and emerging techniques. motor imagery is a mental rehearsal through visualization while mirror therapy creates a reflection of non-effected limb by using a mirror. moreover, motor relearning is task-oriented approach, benefacial for balance and motor function in patients with stroke that emphasizes on relearning.the aim of the study is to determine the comparative effects of motor imagery and mirror therapy versus motor relearning program in addition to routine physical therapy on balance, motor function and activities of daily living in subacute stroke patients.

this randomized clinical trial will be conducted at medical centre fifty stroke patients will be included using convenience sampling technique. the participants in the study will be randomly allocated in to two groups . twenty five participants will be included in both groups a d b. group a (motor imagery and mirror therapy) will receive 60 minutes treatment session that consists of 20 minutes motor imagery, 20 minutes mirror therapy along with 20 minutes routine physical therapy and group b (motor relearning program) will receive treatment session of 60 minutes including motor relearning program of 40 minutes duration along with routine physical therapy of 20 minutes. both groups will undergo 60 minutes session for 5 days per week for 12 weeks. berg balance scale will be used to assess balance, fugl-meyer assessment to assess motor function and functional independence measure for activities of daily living. assessment will be carried out at baseline, 4th week, 8th week and at 12th week after the discontinuation of treatment.

Eligibility criteria:
inclusion criteria: 1. stroke patient of both gender. 2. stroke patient of age 40-65 year . 3. patient diagnosis of cerebral ischemic stroke . 4. patients who had suffered a stroke with hemiplegia, were subacute at least 3 months to 5 months since the onset. 5. ability to walk with minimal assistance (functional ambulation category 1 to 3. 6. patient with score \> 25 on mini-mental status examination. exclusion criteria: 1. patients who presented with hemiplegic neglect or apraxia 2. patients with history of global or receptive aphasia 3. patients with history of psychological or emotional problems 4. patients with history of decompensated cardiovascular/ respiratory/ digestive/ renal disorders, biologic inflammatory syndrome, neoplastic disorders, neurogenic bladder or skin disorders (bedsores). 5. patients with history of artificial joints

Keywords: mirror therapy motor relearning programme stroke motor imagery
detection and neurological impact of cerebrovascular events in noncardiac surgery patients: a cohort evaluation

Conditions: Covert Postoperative Stroke

Summary: the neurovision study will characterize the incidence, impact, and risk factors of covert stroke in adults undergoing noncardiac surgery. we will determine the incidence of acute covert stroke using an mri study of the brain in the days following noncardiac surgery. we will characterize the epidemiology and the impact of covert stroke in patients undergoing noncardiac surgery, and its association with cerebral deoxygenation.

at the university of wisconsin a planned sub study of neurovision is being conducted aiming to enroll 100 patients with additional cognitive testing, mri sequences and a preoperative mri scan. at hamilton juravinski hospital, hamilton general hospital, auckland city hospital and prince of wales hospital a planned sub study of neurovision (pafs - perioperative atrial fibrillation and postoperative stroke) is being conducted aiming to enroll 400 participants. the purpose of this sub-study is to determine the prevalence of af(atrial fibrillation) before surgery (i.e. "background" af), as well of the incidence of af after surgery using the icentia cardiostat "patch-like" single lead heart rhythm monitor.

Eligibility criteria:
inclusion criteria: * age ≥65 years old * an anticipated hospital stay of at least 2 days after elective noncardiac surgery that occurs under general or neuraxial anesthesia * written informed consent for potential participation prior to noncardiac surgery exclusion criteria: * contraindication to mri (e.g. implanted devices not safe for mri studies, claustrophobia) * unable or unwilling to attend the follow-up appointments * documented history of dementia * residing in a nursing home * undergoing carotid artery surgery or intracranial surgery * unable to complete neurocognitive testing due to language, vision or hearing impairment * unable to communicate with the research staff due to language barriers * patients who do not undergo their research mri study after surgery * patients who do not complete a baseline moca questionnaire * patients who suffer an acute overt clinical stroke after the index surgery, but before their research mr study * previously enrolled in the neurovision study.
compliance with proms detection through digital support and correlation compared to standard outpatient proms detection in hip prosthetics (dig-proms-h)

Conditions: Quality of Life

Summary: two methods for detecting outcomes after hip prosthetic surgery are compared: the traditional one using paper questionnaires administered in the outpatient setting (womac score) vs detection using digital questionnaires created on google forms and sent to the patient's smartphone on which the compilation takes place in the extra area outpatient.

proms (patient reported outcomes measures) are used globally for the evaluation of the results of a prosthetic surgery. one of the most used methods in the evaluation of proms in hip prosthetic surgery is the womac score, usually measured in an outpatient setting using paper questionnaires. the aim of the study is to investigate the validity of an alternative method of evaluating proms in which the questionnaire will be administered to the patient digitally (google forms) in an out-of-patient setting. the questionnaire aimed at the subjective evaluation of the discomfort induced by arthrosis of the hip (womac score), will be administered during the pre-hospitalization visits and again during the follow-up visits carried out at 1, 3 and 6 months after intervention. the digital evaluation will be sent to the patient during the outpatient visits and will be considered valid only if completed within 48 hours of the same. on each patient the measurements will be carried out in both methods and differences in terms of compliance and satisfaction with the two methods under examination will be detected. any differences in the final result of the womac score compared to the two methods and the differences in terms of outpatient assessment times will also be evaluated.

Eligibility criteria:
inclusion criteria: * patients with coxarthrosis with indication of hip arthroplasty * males and females aged 18-78 and with a barthel scale score ≥ 91 * patients in possession of private digital electronic support (smartphone, tablet or pc) exclusion criteria: * patients with a barthel scale score ≤ 90 * patients with psychiatric pathologies, a history of drug and alcohol abuse * patients not in possession of private digital electronic support

Keywords: proms digital hip prosthesis womac score
heart muscle viability and remodeling in individuals post-heart attack

Conditions: Cardiovascular Diseases; Coronary Disease; Myocardial Infarction; Heart Diseases; Heart Failure, Congestive

Summary: the purpose of this study is to assess the effect of heart muscle viability on left ventricular (lv) remodeling after a heart attack; to explore the relationships between retained viability of the area of tissue death (infarct zone), lv remodeling, response to the occluded artery trial (oat) intervention, and response to late percutaneous coronary intervention of the infarct related artery (ira).

background: coronary heart disease is a major health problem in the united states. it is estimated that in 2003, more than 600,000 americans had a new heart attack, and more than 400,000 experienced a recurrent heart attack. up to 40% of individuals with a new or recurrent heart attack will show a complete occlusion, or blocking, of the ira on follow-up angiography. many people with an occluded ira post-heart attack are at risk for progressive lv remodeling in the heart, which can lead to congestive heart failure. the nhlbi-funded oat study is testing the hypothesis that opening an occluded ira 3 to 28 days following a heart attack will reduce the composite endpoint of mortality, recurrent heart attack, and new york heart association class iv heart failure over a three-year follow-up period. oat has enrolled approximately 1,100 participants at 240 centers in 24 countries. among the mechanisms proposed to explain the benefit of late revascularization, recovery of lv function and attenuation of lv remodeling due to restoration of blood flow to viable myocardium, or heart muscle, is the most plausible. design narrative: an estimated 200 individuals who have had a heart attack will be enrolled in this study. the primary aims of this study are the following: 1) to test the hypothesis that participants who demonstrate preservation of viability within the infarct zone will have less progressive remodeling compared to participants exhibiting predominant infarct, and 2) to test the hypothesis that preservation of viability will modify the treatment effect of randomization to late revascularization in participants with an occluded ira 3 to 28 days after the heart attack. all participants will have resting gated tc-99m sestamibi spect imaging at baseline, and again 1 year later. parameters of baseline viability within the infarct zone, and serial measures of lv volume change and function will be centrally assessed by the cardiac imaging core laboratory at tufts medical center. the major study endpoint to address the hypotheses will be serial change in lv end-diastolic volume, based on the degree of preservation of viability within the defined infarct zone. sample size calculations will be based on data evaluated by the same group from a similar number of participants studied at a similar number of clinical sites.

Eligibility criteria:
inclusion criteria: * has experienced a heart attack 3 to 28 days prior to study entry * has an occluded ira at catheterization
combining behavioral treatment with agonist maintenance - 1

Conditions: Cocaine-Related Disorders; Opioid-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is to evaluate whether the community reinforcement approach (cra) plus contingency management (cm) is more effective overall than cra only in reducing illicit opioid and cocaine use during agonist maintenance treatment and at 3 and 6 month follow-up after completion of study protocol, and to compare the efficacy of maintenance on buprenorphine to methadone when maintenance is combined with cra only or cra plus cm.


Eligibility criteria:
please contact site for information.

Keywords: cocaine-related disorders opioid-related disorders substance-related disorders
cardiac magnetic resonance imaging after cardiac resynchronization therapy

Conditions: Heart Failure, Systolic

Summary: this study is evaluating how mri after crt can provide key insights regarding lv function, structure, and mechanics resulting from crt in patients with or without lv scar and inform optimal pacing strategies. the expected accurate and reproducible response assessment with cardiac mri has important implications for evaluating crt outcomes in clinical trials, and the insights from the post-crt mri promise to improve implementation of crt.

we are performing a study of 40 patients with current accepted indications for crt and no mri contraindications. these patients will have a pre-crt mri and another post-crt mri 6 months after the crt procedure. echocardiography, cardiopulmonary exercise testing, symptom assessment, and laboratory testing are also performed before and after crt. modifications to the post-crt mri protocol include the use of gradient echo cine imaging rather than steady state free precession imaging, application of wideband imaging to the lge acquisitions, and strain imaging with cine displacement encoding with stimulated echoes (dense) tailored for device patients.

Eligibility criteria:
inclusion criteria: * chronic systolic hf * lvef 35% or less * guideline-based class i or iia indication for crt * 25 and 85 years old * predominantly in sinus rhythm * gfr ≥ 40 ml/min/1.73m2\* \*contrast will not be given for the 6-month follow-up scan if the gfr falls to \< 40 ml/min/1.73m2. exclusion criteria: * inability to provide informed consent * pregnancy * presence of metal embedded in the body due to prior accident or injury, as documented by skull films or other imaging * preexisting pacemaker or defibrillator prior to enrollment * cerebral aneurysm clips; 6) cochlear implants * other metallic implants (prior to enrollment) known to be contraindications to mri * severe claustrophobia * acute kidney injury * acute renal failure or chronic kidney disease with gfr \< 40 cc/min * liver transplant * gadolinium allergy

Keywords: cardiac resynchronization therapy implantable cardioverter defibrillator heart failure magnetic resonance imaging