Kornimate/medical-research-clean huggingface dataset:
red blood cell lifespan

Conditions: Chronic Kidney Disease; Hemodialysis

Summary: background: a low amount of red blood cells in the blood of patients with limited kidney function is a well known problem. besides the lack of substances in the blood like iron or erythropoietin the shortened survival of red blood cells leads to the low red blood cell count. red blood cells of patients on kidney replacement therapy (dialysis) die earlier than those of healthy persons. they live only about 70 days compared to 120 days in healthy humans. today little is known about the causes for the shorter survival of the red blood cells in patients on dialysis. because inflammation leads to a shorter life of the red blood cells in people suffering from several diseases leading to inflammation we would like to learn about the role of inflammation in the shortened life of red blood cells of dialysis patients. when red blood cells are dying the content is broken down to several substances. one of these substances is the gas carbon monoxide (co). the carbon monoxide is exhaled with the breath. the more red blood cells die the more co is exhaled. that's why we can calculate the lifespan of the red blood cells when we measure the amount of co in breath at the same time as the red blood cell count in the blood. aim of the study: we aim to learn about the influence of inflammation of on red blood cell survival in dialysis patients. to look for factors with effect on inflammation or red blood cell survival, for example type of dialysis access, medication or kind of dialysis treatment. study procedures: over the course of the 18 month study, 6 observational assessments will take place. if the patient experiences a situation with increased inflammation during the study period (for example any kind of infection or intervention) up to two more study visits will take place. each study visit will include blood sampling, performed without the need for an extra needle stick, and a breath sampling in order to calculate the red blood survival and to measure markers for inflammation in the blood. the breath sample will be taken using the easy to use gasampler device developed by a company called quintron especially for medical breath sampling. in order to get a sample of air at the patient's home for calculation of carbon monoxide produced in the body we will ask the patients to take home an open empty plastic bottle before each study visit. the bottle should be kept overnight on a table or sideboard in the apartment. before leaving home for hemodialysis or in clinic visit the patient will seal the plastic bottle with the top, take it to the dialysis center and hand it to the research staff. risks: the amount of the additional blood drawn is 30 ml; this is the amount 2 tablespoons, at each study visit. this does not harm the patient. the breath sampling does not imply any risk.


Eligibility criteria:
inclusion criteria: * age greater than 18 years * chronic hemo- or peritoneal dialysis treatment greater than 3 months exclusion criteria: * inability to understand the english language and give informed consent for participation in the study
brain stimulation for traumatic brain injury

Conditions: Traumatic Brain Injury; Diffuse Axonal Injury

Summary: the purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rtms) is effective in the cognitive rehabilitation of patients with diffuse axonal injury(dai) after traumatic brain injury(tbi).


Eligibility criteria:
inclusion criteria: * clinical and radiological diagnosis of traumatic brain injury. * between one to two years after traumatic brain injuri * must be able to sign the informed consent form exclusion criteria: * drug addiction * uncontrolled epilepsy * extensive cranial vault defects

Keywords: traumatic brain injury diffuse axonal injury repetitive transcranial magnetic stimulation neuromodulation cognitive rehabilitation
assessing factors in tinnitus patients' clinical study experiences

Conditions: Tinnitus

Summary: clinical trials can sometimes favor certain demographic groups. additionally, there is limited research that delves into the factors that influence participation in clinical trials, both positive and negative. the goal is to identify the obstacles and challenges that prevent participation in tinnitus clinical studies, as well as the reasons for withdrawal or discontinuation. the insights gained from this study will ultimately benefit those with tinnitus who may be invited to participate in clinical research in the years to come.


Eligibility criteria:
inclusion criteria: * diagnosed with tinnitus * willing to comply with all study related procedures and assessments * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * no documented diagnosis of tinnitus * any other health problems that would prohibit safe participation in the study * pregnant or planning to become pregnant while enrolled in the study

Keywords: tinnitus
transauricular vagus nerve stimulation in children

Conditions: Hypoxia-Ischemia, Brain

Summary: the goal of this clinical trial is to learn about brain waves during transauricular vagus nerve stimulation (tavns) in healthy children. the main questions it aims to answer are: * what is the safety, tolerability, and physiological response of tavns in children? * does the electroencephalogram (eeg) change during tavns? participants will * undergo a brief titration session where tavns will be titrated to below perceptual threshold * receive one session of 30 minutes of tavns * undergo clinical eeg monitoring during tavns * continuous cardiorespiratory monitoring via pulse oximetry and blood pressure every 5 minutes * answer tolerability questions before, during and after 30 minute tavns session


Eligibility criteria:
inclusion criteria: * admitted for clinical eeg for spell characterization at investigator's institution exclusion criteria: * known history of brain injury * known history of bradycardia * congenital heart disease * pregnant * pacemaker or wearable defibrillator * undergoing active cancer treatment
myofascial pain and central sensitization

Conditions: Myofascial Pain; Physical Therapy

Summary: this prospective, observational cohort pilot study compared pain phenotyping and functional measures in 30 participants with non-acute neck and/or shoulder girdle pain consistent with primary myofascial pain at 3-months following a physical therapy referral to study the impact of their baseline degree of pain amplification.


Eligibility criteria:
inclusion criteria: * english-speaking participants * diagnosed by their physician with non-acute (more than two weeks) neck and/or shoulder girdle primary myofascial pain * referred to a physical therapy treatment. exclusion criteria: * in an effort to reduce the potential that another medical condition could lead to a secondary myofascial pain response, extensive comorbid exclusion criterion. * use of chronic high-dose opioid medication greater than 100 mg oral morphine equivalents per day. * individuals receiving or applying for compensation or disability. * the inability to provide informed consent. * severe physical impairment (e.g., blindness, deafness) * co-morbid medical condition limiting function (e.g., malignant cancer) * reported illicit drug use * severe psychiatric condition that would limit judgment. * lack of internet access.
immunologic changes and recovery-related factors in elderly colon cancer patients

Conditions: Cancer of Colon; Interleukins; Aged

Summary: colorectal cancer is one of the most frequent malignancies, with a rising proportion of elderly patients in an aging society. in this study, the investigators attempted to find out the relationship between immunologic factors and recovery using various parameters impacting the treatment in elderly patients.

in prospective study, total 75 patients who received radical resection for colon cancer between september 2023 and february 2024 at asan medical center was involved. investigators included colon cancer patients treated with surgery, diagnosed with adenocarcinoma histologically and having information regarding preoperative status with abdominopelvic ct. routine blood sampling and immunologic tests including interleukin-6 (il-6) and natural killer cell (nk cell) were performed at preoperative day, post operative 3rd day (pod#3), and outpatient clinic day (about postoperative 21th day (pod#21)). investigators attempted to assess the patients' subjective health level using a simple questionnaire, euroqol group- 5 dimension- 3 level (eq-5d-3l). the sarcopenia was evaluated by the artificial intelligence software system and defined as an smi \< 41cm2/m2 in women and smi \< 43 cm2/m2 in men with a body mass index (bmi) \< 25kg/m2, and \< 53 cm2/m2 in men with a bmi ≥ 25 kg/m2. in this study, primary end point was recovery represented by hospital stay defined as the day from operation to discharge and readmission within 30days after discharge. secondary end point was eq-5d-3l (only in prospective cohort). 'recovery' was evaluated by hospital stay and readmission within 30 days after discharge. analyses of clinicopathological characteristics of categorical variables and continuous variables were conducted using the chi-square test and t-test, respectively. a multivariable analysis with cox proportional hazards model was used to compare risk factors associated with postoperative hospital day including nlr, agr, albumin, bmi and sarcopenia. investigators conducted an analysis including variables that have been proven to be related to the immune system or recovery in previous studies or that are suspected to be clinically relevant.

Eligibility criteria:
inclusion criteria: * colon cancer patients treated with surgery * diagnosed with adenocarcinoma histologically * having information regarding preoperative status with abdominopelvic ct exclusion criteria: * familial colorectal cancer * malignancies other than adenocarcinoma * inflammatory bowel disease-associated cancer * recurrence * metastasis
effectiveness of ultrasound guided corticoanesthetic injection in carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: effectiveness of ultrasound guided corticoanesthetic injection in carpal tunnel syndrome treatment comparing two different injection sites. single-blind randomized trial.

carpal tunnel syndrome (cts) is the most common nerve entrapment neuropathy. six placebo-controlled trials with 393 participants proved corticosteroid injection to be effective in symptom relief. however, all injections were palpation-guided. therefore, the exact injection site was uncertain. although three studies comparing palpation and ultrasound (us) guided cts injection showed us superiority, the optimal injection site for the injectate delivery remains unclear. some authors believe in thinning of the flexor tenosynovium as the mechanism of the median nerve decompression, and therefore recommend injection between the tendons, away from the nerve. other authors stress the importance of hydrodissection and direct contact of the injectate with the nerve and suggest injection targeting the median nerve. according to our best knowledge, no study comparing different injection sites for a corticosteroid delivery in cts has been published in english written literature. the objective of this study was to determine the optimal target site for the corticosteroid delivery in cts injection.

Eligibility criteria:
inclusion criteria: * primary idiopathic cts * symptoms of classic or probable cts (numbness or tingling in at least 2 of the 4 radial fingers) * unsuccessful 1-month treatment with wrist splinting * nerve conduction test results that showed median neuropathy at the wrist exclusion criteria: * previous steroid injection * diabetes mellitus, * thyroid disorder * inflammatory disease * polyneuropathy * current pregnancy * previous carpal tunnel surgery * severe illness * inability to respond to questionnaires

Keywords: carpal tunnel injection corticosteroid ultrasound-guided musculoskeletal ultrasound
safety and performance of the biphasic plate distal femur: a multicenter case series

Conditions: Distal Femur Fracture; Periprosthetic Fractures; Intra-Articular Fractures; Supracondylar Fracture

Summary: the goal of this observational multicenter case series is to assess the safety and performance of the ce-marked "biphasic plate distal femur" during standard of care.

the goal of this observational study is to assess the safety and performance of the ce-marked "biphasic plate distal femur" during standard of care. the study is conducted as a retrospective and prospective multicenter case series. eligible patients are those with fractures of the distal femur who are treated with the biphasic plate df according to the instruction for use (ifu). the patient will be followed-up until healing or up to 12 months, whichever comes first. to assess the safety and performance following data is collected: * incidents of aes/saes occurring in the affected lower extremity/extremities * bone healing assessed by a surgeon * weightbearing and function * patients' quality of life and pain level

Eligibility criteria:
inclusion criteria: * patients with fractures of the distal femur requiring internal fixation and treated with the biphasic plate df as indicated according to the ifu. as per the ifu, the biphasic plate df is indicated for: * distal shaft fractures * supracondylar fractures * intraarticular fractures * periprosthetic fractures * no other major implant beside the biphasic plate df is used for fixation of the distal femur fracture, with the exceptions of lag screw(s) and/or cerclage wire(s), and/or a joint replacement. * patients who are willing and able to comply with postoperative fus per local standard of care. * ability to provide informed consent according to the irb/ec defined and approved procedures. * patients over 18 years of age exclusion criteria (preoperatively): * patient is participating in another interventional clinical trial. exclusion criteria (intraoperatively): * change of surgical plan intraoperatively at the discretion of the surgeon that biphasic plate df is not used * necessity to apply a second (medial) plate (double plating) or an intramedullary nail in case of critical fixation distally

Keywords: biphasic plate df distal femur fracture femur fracture periprosthetic fractures intra-articular fractures
goalkeeper: intelligent information sharing for children with medical complexity

Conditions: Childhood Cancer; Cerebral Palsy; Chronic Lung Disease; Congenital Heart Disease; Congenital Metabolic Disorder; Gastrostomy

Summary: this proposal addresses the major challenge of improving health outcomes for children with cancer and other complex conditions, for whom the effectiveness of outpatient care depends on care coordination across a diverse group of caregivers that includes parents, community support organizations and pediatric care providers. the investigators have developed goalkeeper, a prototype system for supporting care coordination across multiple care providers. the primary aim of the clinical trial is to assess the potential for this new system, goalkeeper, to improve meaningful use of goal-centered care plans in the care of children with cancer and other complex chronic conditions.

the overarching aim of the research is to improve care coordination and goal setting for children with medical complexity (cmc). specific aims of the pilot clinical trail are as follows: (1) to assess the efficacy of goalkeeper on goal-setting in the health care encounter. (2) to examine the roles of parent health literacy and parent activation in moderating the effect of the intervention. study population: stanford's primary and subspecialty care clinics at stanford children's health will serve as the setting for study recruitment. the pilot randomized controlled trial will enroll 60 parents of children with medical complexity and their health-care providers. eligibility criteria for participants will be age 18 years or older, english-speaking, and (for parents) child\<12 years old. exclusion criteria are parent with known mental illness or neurocognitive impairment. a stepped wedge approach by provider will introduce families to goalkeeper at different time points in the study. a pre-intervention period will occur at least 1 month before the trial start where clinical observations and baseline survey information will be obtained of each providers' practice. each family will be given training and 4-month access to the goalkeeper application and participate in an exit interview at the end of study.

Eligibility criteria:
inclusion criteria: * parent-child dyads and their medical provider * parent and provider age 18 years or older * parent english- or spanish-speaking * child \> age 12 months and \<12 years old exclusion criteria: * parent with known mental illness or neurocognitive impairment.

Keywords: complex chronic condition care coordination shared decision making health literacy
a study of the use of vaginal radiofrequency therapy in treatment of sui.

Conditions: Urinary Incontinence, Stress

Summary: to investigate the immediate, short-term and long-term efficacy of vaginal radiofrequency therapy in the treatment of stress urinary incontinence, and to compare the efficacy of pelvic floor electromyography combined with biofeedback therapy in stress urinary incontinence.

before treatment, patients with mild and moderate stress urinary incontinence were diagnosed according to the diagnostic criteria through medical history inquiry and gynecological physical examination, and patients were screened according to the inclusion and exclusion criteria. after informing two treatment plans and signing the informed consent, they were randomly divided into vaginal radiofrequency therapy group and electrical stimulation combined biofeedback group. after being included in the test, one hour urine pad test was conducted, and iiq-7, pisq-12 and fsfi questionnaires were completed. iiq-7, pisq-12 and fsfi questionnaires were followed up 1, 3, 6 and 12 months after treatment. after 3 months and 1 year of treatment, 1 hour urine pad test was given again.

Eligibility criteria:
inclusion criteria: 18-75 years old women with a sexual history, and patients with mild to moderate stress urinary incontinence. exclusion criteria: severe cardiopulmonary insufficiency, acute pelvic inflammatory disease or other infectious stage, non-steroidal anti-inflammatory drugs and steroid hormones affecting collagen production factors, pop-q-2 and above prolapse.
descriptive observational study on the characteristics of advanced and metastatic melanoma in spain

Conditions: Melanoma Stage Iv; Melanoma Stage Iii; Advanced Cancer

Summary: this is an observational, multicentre epidemiological study with a longitudinal cohort in which information will be retrieved from medical records of patients with advanced metastatic or unresectable melanoma at first diagnosis.


Eligibility criteria:
inclusion criteria: * patients of legal age with stage iii, metastatic, or unresectable melanoma at first diagnosis after january 8, 2018. first diagnosis is understood as: a. disease onset as metastatic or unresectable disease; b. first metastatic or unresectable relapse in the pre-established dates (after january 8, 2018) in a patient with previous localised melanoma and completely resected on dates before the pre-inclusion period. * signing the informed consent form (icf). * a patient may have received the first or subsequent treatments for metastatic or unresectable disease in a hospital other than the centre where the icf was signed, as long as the patient meets the inclusion criteria 1. * a patient can only sign one icf (cannot sign an icf in two different centres). * if a patient signs the icf in a centre during the first-line therapy and then goes to another centre with consideration for the following lines: if the centre is associated with the gem-1801 study, researchers will do their best to update the following lines and the patient status, introducing the new information in the centre where the icf was initially signed. this information will be provided by the patient before contacting the principal investigator and always with prior consent of the patient, who will have previously provided the consent to contact by telephone for this purpose. if this second (or subsequent) centre is not associated with the gem- 1801 study, this will be considered loss of follow-up, unless the patient returns to the gem-1801 start centre, wherein the reporting physicians will do their best to update the information from other centres, always with prior patient consent, who will have previously signed the icf; c) a patient card with the assigned code will be delivered. exclusion criteria: * any patient not complying with inclusion criteria.
open lung protective ventilation in cardiac surgery

Conditions: Hypoxemia

Summary: cardiac surgery with cardiopulmonary bypass (cpb) frequently induces post-operative respiratory dysfunction. the post-operative pulmonary complications (ppcs) significantly increase the peri-operative morbidity and require invasive treatments during longer and more expensive icu stays. a specific pathophysiology involving general anesthesia and cpb-related factors (inflammation, pulmonary ischemia) has been clearly demonstrated and pulmonary atelectasis seems to play a central role in the occurence of these ppcs. the open lung approach is a ventilation strategy that aims to "open the lung and keep it open" using different ventilatory settings. the efficacy of that strategy is not demonstrated in the global surgical population. however, its application in the perioperative care of cardiac surgery patients could be of great interest by counteracting the development of atelectasis. the purpose of this multicentre, double blinded, randomized controlled study is to evaluate the influence of a perioperative multimodal protective ventilation strategy based on the "open lung approach" on postoperative outcomes during the first 7 days following cardiac surgery. participating centres will include 500 adult patients undergoing scheduled on-pump cardiac surgery. the open lung approach will combine recruitment maneuvers (rm), positive end expiratory pressure (peep) at 8 cmh2o from intubation to detubation and continuation of ultraprotective ventilation during cpb. it will be compared to a conventional approach without rm, with peep at 2 cmh2o and discontinuation of ventilation during cpb. the primary endpoint is any post-operative pulmonary complication. the secondary endpoints are any post-operative extra-pulmonary complications and the number of icu-free days to day 7.


Eligibility criteria:
inclusion criteria: * cardiac surgery planned with cpb and sternotomy. * age \> 18 years old. exclusion criteria: * urgent surgery : cardiac transplantation, aortic dissection, active endocarditis. * aortic arch surgery with circulatory arrest. * lvad surgery. * acute or chronic preoperative hypoxemia (pao2 \< 65 mmhg in air). * preoperative shock state requiring catecholamines. * lvef \< 40%. * pulmonary hypertension with systolic pulmonary artery pressure \> 50 mmhg. * severe right ventricular dysfunction (tdi tricuspid annular systolic velocity \< 10 cm.s-1). * chronic kidney disease (glomerular filtration rate \< 30 ml/min). * body mass index \> 35kg/m2. * patient's refusal.