Kornimate/medical-research-clean huggingface dataset:
adjusted individual oral feeding for improving short and long term outcomes of preterm infants

Conditions: Body Weight Changes; Feeding and Eating Disorders of Childhood; Breast Feeding; Evoked Response Audiometry

Summary: the authors hypothesize that adjusted individual feeding (aif) for preterm infant starting from transition to oral feeding (33 weeks corrected age) will result in less episodes of apnea/bradycardia, early achievement of full oral feeding, improved weight gain and shorten hospitalization duration in the short term. in the long term aif will result in higher scores on the griffith's developmental scales, decreasing parental anxiety and feeding disorders .

preterm infants born at \<32 weeks of gestation at our institute will qualify for this study. recruitment will occur between day 7-14 of life after sever brain malformations or intraventricular bleeding will be ruled out. randomization to control or intervention will be via sealed envelopes. in the control group - infants will be treated according to the common practice in the neonatal intensive care unit. transition to oral feeding will occur at 33 wkks (breast feeding) and 34 wks (bottle feeding). meals will be given every 3 hours, the amount will be written by the care giving physician and will be written as a strict number (i.e 30 ml every 3 hours) parents in the intervention group will be taught be the nurses (nidcap trainees) to identify their infants' ques (self regulation or withdrawn as well as signs of hunger), this parents will be taught the physiology of maturation of feeding, as well as various techniques of infants feeding amongst them pace feeding. during the study parents in both groups will be interviewed every 14 days as for their satisfactions, anxieties, infants ability to cope. video typing during kangaroo care at 32 and 35 wks as well as during feeding at 35 weeks will be done and evaluated. general movements assessment (neurodevelopment) will be done at 33 -35 weeks gestational age, as well as at 52 weeks. alberta infant motor scales will be evaluated at 4 and 8 month corrected age,automated brain stem evoked response (abr) will be done at 33 wks for assessment of brain stem maturity, duration of hospitalization, weight gain per week at 33, 34 and 35 weeks will be calculated, age at full oral feeding will be noted. at the age of 6 month griffith's developmental scales will be performed

Eligibility criteria:
inclusion criteria: - birth at less than 32 weeks of gestation exclusion criteria: * high grade intraventricular hemorrhage (grade 3 or4) * genetic syndrome

Keywords: preterm oral feeding outcome
cohort study of clinically isolated syndrome and early multiple sclerosis

Conditions: Multiple Sclerosis, MS; Clinically Isolated Syndrome

Summary: a majority of patients with multiple sclerosis initially presents with a single demyelinating event, e.g. in the optic nerves, brain, brainstem or spinal cord, referred to as a clinically isolated syndrome (cis). not all patients with cis get a relapse and develop multiple sclerosis but in those patients who do, irreversible damage of the central nervous system, e.g. axonal damage, is already detectable in that early stage of disease. early initiation of immunomodulatory therapy is crucial for patients with clinically isolated syndrome who are at high risk for the development of multiple sclerosis. vice versa identification of low risk patients could help to avoid an unnecessary therapy. in this prospective observational study we want to follow up patients with cis and early multiple sclerosis over a period of four years and obtain clinical, laboratory and mri - data in order to identify risk factors for relapses, prognostic factors and therapy response markers.


Eligibility criteria:
inclusion criteria: * age \> 18 years * signed informed consent * clinically isolated syndrome within the last 6 months * diagnosis of multiple sclerosis within the last two years exclusion criteria: * eye disease that could interfere with oct (e.g. glaucoma, diabetic retinopathy) * secondary progressive multiple sclerosis * pregnancy * contraindications for mri, e.g. pacemaker, metal implants, allergy against gadolinium * alcohol or drug abuse

Keywords: clinically isolated syndrome (cis) multiple sclerosis (ms) immunomodulatory therapy prognostic markers mri oct
effect of planned visual training on heart failure patients

Conditions: Heart Failure

Summary: this study was conducted to evaluate the effects of planned visual education based on the health belief model on the attitudes, beliefs, and symptoms of heart failure patients towards their disease. planned visual education based on the health belief model has positive effects on the attitudes, beliefs, and symptoms of heart failure patients towards their disease.

this study, which evaluated the effects of planned visual education based on the health belief model on the attitudes, beliefs, and symptoms of patients with heart failure towards their disease, was conducted with 110 heart failure patients. the study was planned as a randomized controlled experimental study conducted on two groups as intervention (n = 55) and control group (n = 55). the study was conducted between september 2021 and march 2022 at manisa celal bayar university (mcbu) hafsa sultan hospital cardiology polyclinic. simple randomization method was used in assigning the sample group to the experimental and control groups. data were collected using "the patient identification form", "the health belief model scale - heart failure" and "memorial symptom assessment scale - heart failure".

Eligibility criteria:
inclusion criteria: * patients aged between 18 and 65, * those with no communication problems, * those diagnosed with nyha i-ii heart failure, * those without cognitive impairment, * those who can understand and speak turkish, * those who agree to participate in the study. exclusion criteria: * patients who do not agree to participate in the study, * patients who want to leave the study, * patients with nyha iii-iv heart failure diagnosis, * patients diagnosed with cancer, * patients with diabetic foot or amputation.

Keywords: heart failure health belief model patient training nursing
prophylactic treatment with oseltamivir

Conditions: Influenza, Human

Summary: the purpose of this study is to compare the efficacy of 5-day versus 10-day oseltamivir prophylactic treatment in patients who had been exposed to influenza.


Eligibility criteria:
inclusion criteria: * 18 years or older * exposure to influenza during hospitalization * risk factors for influenza complications * consent for participation obtained exclusion criteria: * younger than 18 years * hematological malignancy * hospitalized in intensive care unit * refusal to participate
the role of lactobacillus reuteri in preventing necrotizing enterocolitis (nec) in pre-term infants

Conditions: Necrotizing Enterocolitis; Sepsis

Summary: the purpose of this study is to compare the effectiveness of l. reuteri with placebo in prevention of nec in children, as according to my knowledge, there is limited work is done nationally and internationally. probiotics are being used in our children hospital and the institute of child health, multan. route of administration of l. reuteri will be oral or via nasogastric tube due to availability of oral form in pakistan. the results of this study will be helpful to assess the beneficial effects of probiotics especially l. reuteri in nec in preterm. so, they can be recommended as preventive strategy to avoid nec development and its complications based on its availability, effectivity and easy administration


Eligibility criteria:
inclusion criteria: * preterm neonate\ 28 weeks of gestation of both genders hemodynamically stable exclusion criteria: * preterm neonates \>34 weeks gestational age \< 28 weeks of gestation cardiorespiratory illness parental refusal

Keywords: necrotizing enterocolitis, lactobacillus reuteri ds 17938
invent-in-office study

Conditions: Otitis Media

Summary: the objective of the study is to evaluate the safety and efficacy of the acclarent tympanostomy tube delivery system (ttds) for the placement of tympanostomy tubes (tt) under local anesthesia in an office/clinic setting.


Eligibility criteria:
inclusion criteria: * scheduled to undergo tympanostomy tube insertion * at least 6 months old * behavioral capacity and cooperative temperament to undergo an awake procedure (based on physician judgement) exclusion criteria: * history of sensitivity or reaction to anesthesia chosen for the procedure * significantly atrophic, bimeric, or completely atelectatic tympanic membrane * otitis externa * anatomy that precludes sufficient visualization of and access to the tympanic membrane * anatomy that necessitates tympanostomy tube placement in the posterior half of the tympanic membrane

Keywords: tympanostomy tube placement
behavioral economic approaches to increase colorectal cancer screening

Conditions: Cancer of the Colon

Summary: this is an rct aimed at testing different population-based approaches to increasing colorectal cancer screening through email outreach, including usual email communication, active choice, and active choice + financial incentive.

this is an rct aimed at testing different population-based approaches to increasing colorectal cancer screening. the investigators will randomize a cohort of employees between the ages of 50-64 to 3 arms of email communications: a.) usual email communication; b.) active choice- usual care + the ability to pre-commit directly through a web form; c.) financial incentive- usual care + active choice + financial incentive for completion.

Eligibility criteria:
inclusion criteria: * male and female employees of the university of pennsylvania health system who live within 30 miles of a health system endoscopy center.
nature (envast as an adjunct ppci in subjects presenting with stemi)

Conditions: Segment Elevation Myocardial Infarction (STEMI)

Summary: this study is designed to compare the safety and effectiveness of blood clot (thrombus) removal in subjects presenting with st-segment elevation myocardial infarction (stemi) with the envast coronary system versus conventional intervention.

a prospective, multi-center, randomized clinical trial designed to assess the safety and effectiveness of the envast coronary thrombectomy system as an adjunctive measure to conventional intervention in subjects presenting with st-segment elevation myocardial infarction (stemi).

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. chest pain for \> 20 min with an electrocardiographic st-segment elevation ≥ 1 mm in two or more contiguous electrocardiogram (ecg) leads or an infero-lateral myocardial infarction (mi) with st segment depression of ≥ 1 mm in ≥ 2 of leads v1-3 with a positive terminal t wave. 3. timi thrombus grade ≥ 3 in the infarct related artery. in cases where timi thrombus grade is equal to 5 (i.e. timi 0 flow in the infarcted artery), timi thrombus grade of at least 3 has to be re-confirmed with awi. patients showing timi thrombus grade of less than 3 upon awi are no longer eligible for randomization. 4. start of intervention within 8 h of symptom onset 5. subject is willing and able to provide informed consent prior to the intervention exclusion criteria: 1. unconscious patients 2. infarct related artery diameter, at visual assessment, smaller than 2.5 mm 3. presence of severely calcified plaque(s) proximal to or at the site of the culprit lesion(s) 4. presence of extreme vessel tortuosity proximal to or at the site of the culprit lesion(s) 5. women of child-bearing potential (e.g. below 55 years of age, who have not undergone tubal ligation, ovariectomy or hysterectomy and last menstruation within the last 12 months) 6. stent thrombosis as culprit lesion 7. previous myocardial infarction in the same territory (i.e. same target vessel) 8. participation in another interventional clinical trial
coronary artery vasculopathy in pediatric heart transplant patients

Conditions: Orthotopic Heart Transplant

Summary: heart transplantation is a life-sustaining therapy that allows patients with either congenital or acquired heart disease and severe cardiac dysfunction to survive. over time, however, the transplanted heart can develop problems. one of the more common and troubling problems is the development of stenoses, or narrowings, within the coronary arteries. these narrowings, technically referred to as coronary artery vasculopathy (cav for short), account for the single most common cause of death or need for repeat heart transplant in persons more than one year post-transplant. traditionally, cav has been diagnosed at cardiac catheterization using coronary angiography (where dye is directly injected into the coronary blood vessels and viewed using special x-ray equipment called fluoroscopy). there is no good treatment for cav aside from treatment of symptoms and listing for repeat heart transplantation. the goal of this study is to test several newer methods of diagnosing cav. the first is called coronary flow reserve (catheterization test). the second is called endo-pat (a finger probe test) and the third is called contrast-enhanced cardiac mri (mri test, only for patients 12 and older). the older method (coronary angiography) will still be used in all cases, in addition to the new tests the goal is, one day, to be able to diagnose patients with cav earlier in the course, prior to a patient's development of abnormal angiograms. if this can be done, it is possible that better therapies will be able to be used to stop or even reverse the development of cav, perhaps reducing, or at least delaying, the need for repeat heart transplantation.


Eligibility criteria:
inclusion criteria: * patients age 1 - 25 years who are status-post oht (≤18 years at the time of transplantation) and undergoing routine post-transplant surveillance catheterization for endomyocardial biopsy and coronary angiography exclusion criteria: * the presence of sick sinus syndrome or 2nd or 3rd degree atrioventricular block (without a functioning implanted pacemaker) * hemodynamically significant valvular disease * severe asthma or bronchospasm, known severe cav * pulmonary hypertension. * patients taking digoxin * verapamil and dipyridamole are also excluded given known interactions with adenosine.

Keywords: orthotopic heart transplant
immunological consequences of obstructive sleep apnea

Conditions: Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) is a medical problem whose importance is increasing in recognition and awareness. osa is associated with the development of hypertension and other cardiovascular diseases (1,2). osa has pathophysiologic characteristics that are known to negatively impact immune function. both sleep deprivation and hypoxia, hallmarks of osa, impair immune responses (6,8,11). in addition, patients with osa are frequently obese and obesity may be associated with increased chance of infections and immune impairment (14,15). adipose cells are known to secrete cytokines and hormones that are involved in the immune response such as leptin, tumor necrosis factor alpha and interleukin-6 (16-19). thus, it seems very likely that osa may impact antigen-specific immune responses. although it is known that characteristics of osa impact immune function, it is not known what effects clinical osa has on immunity. the central hypothesis of this application is that that patients with obstructive sleep apnea will have attenuated cell-mediated and humoral immune responses to influenza vaccine compared to matched control subjects. our hypothesis has been formulated on the basis that patients with osa are sleep deprived and experience repeated hypoxemia that negatively impact both humoral and cell-mediated immune responses.


Eligibility criteria:
inclusion criteria: * absence of any immunocompromising diseases or medical conditions * not taking any immune modifying medications or supplements * significant obstructive sleep apnea as verified by complete overnight polysomnography with apnea-hypopnea index (ahi) \> 15 events per hour (sleep apnea subjects) * free of sleep disordered breathing verified by complete overnight polysomnography (ahi \< 5 events per hour) or oximetry (\< 5 desaturations per hour) (control subjects) exclusion criteria: * documented history of allergy to influenza vaccine or any of its components
long term follow-up (ltfu) of subjects who received sb-318, sb-913, or sb-fix

Conditions: Hemophilia B; Mucopolysaccharidosis I; Mucopolysaccharidosis II

Summary: long-term follow-up of subjects who received sb-318, sb-913, or sb-fix in a previous trial and completed at least 52 weeks post-infusion follow-up in their primary protocol. enrolled subjects will be followed for a total of up to 10 years following exposure to sb-318, sb-913, or sb-fix.

non-interventional, multi-center, long-term follow-up (ltfu) study of subjects dosed with sb-318 in the clinical study sb-318-1502, sb-913 in the clinical study sb-913-1602, and sb-fix in clinical study sb-fix-1501. all subjects dosed in the studies and completed at least 52 weeks post-infusion follow-up in their primary protocol will be offered to participate. subjects who enroll will be monitored for a total of up to 10 years following exposure to the respective investigational products.

Eligibility criteria:
inclusion criteria: 1. subjects who received sb-318 under study protocol sb-318-1502, sb-913 under study protocol sb-913-1602, or sb-fix under study protocol sb-fix-1501 2. subjects who have provided consent to participate in the ltfu study. exclusion criteria: 1. unable to comply with study visit schedule or study visit procedures. 2. any other reason that, in the opinion of the investigator or medical monitor, would render the subject unsuitable for participation in the study.

Keywords: mucopolysaccharidosis i hurler-scheie syndrome mucopolysaccharidosis ii hunter syndrome gene editing gene therapy zinc finger sb-318 sb-913 sb-fix rare genetic dna sangamo zfn long term hemophilia b mps
u/s guided vs. traditional palpation for radial artery cannulation

Conditions: Critical Illness

Summary: the purpose of this study is to compare the efficacy of ultrasound- guided with the traditional palpation radial artery cannulation in critically ill children.

arterial catheterization is often performed in critically ill patients for continuous hemodynamic monitoring and blood sampling. however, insertion of radial artery catheter with traditional palpation may be technically challenging, particularly in pediatric patients. there are few published studies on the use of ultrasound guidance for radial-artery catheter placement and mostly they were elective surgery children which received inhalation or deep sedative medication. recently no setting published in pediatric intensive care unit.

Eligibility criteria:
inclusion criteria: * pediatric patients who required radial artery cannulation for hemodynamic monitoring or frequent blood samples in intensive care unit exclusion criteria: * wound at area of cannulation * can not palpate or weak radial artery pulse
research on the application of patient navigation-based management model of patients after leep

Conditions: Cervical Intraepithelial Neoplasias

Summary: cervical cancer poses a significant threat to women's health and is a crucial public health issue. early detection and treatment of cervical lesions and standardized management have emerged as essential pillars in the global cervical cancer elimination. the loop electrosurgical excision procedure (leep) is widely employed as a preferred approach for the diagnosis and treatment of precancerous cervical lesions and early invasive cervical cancer. patients with high-grade cervical lesions are more prone to experiencing sexual dysfunction and psychological disorders after leep, attributed to the unique surgical site, physiological alterations, and psychological stress during the postoperative recovery process, thereby adversely affecting their quality of life. currently, there is a shortage of research evidence regarding targeted intervention measures and long-term effect evaluations for sexual function quality and quality of life after leep for cervical lesions. in recent years, the health management model based on patient navigation has evolved into a novel modality for facilitating comprehensive tumor prevention and control. however, its effect in managing cervical lesions has yet to be comprehensively assessed. therefore, we will design a randomized controlled trial to evaluate the impact of a patient navigation-based health management model on quality of life and sexual function after leep in patients with cervical lesions.


Eligibility criteria:
inclusion criteria: * individuals aged between 25 and 50 years; * leep will be conducted following clinical evaluation; * no intention to conceive within the subsequent year; * proficiency in utilizing social media platforms, such as wechat, is required; * patients must be capable of providing informed consent to participate in the study and willing to engage in long-term follow-up. exclusion criteria: * individuals who are widowed, separated, or experiencing atypical sexual activity due to reasons related to their spouse. * presence of genital tract malformations. * a history of neurological disorders, such as stroke or epilepsy, or a history of psychiatric conditions, such as depression. * patients with other significant illnesses that could impact the long-term follow-up of the study.

Keywords: loop electrosurgical excision procedure patient navigation quality of life sexual function
forced versus spray coagulation in women undergoing lletz-conization for cervical dysplasia: a randomized trial

Conditions: Uterine Cervical Dysplasia

Summary: in a randomized clinical trial of 120 women undergoing large loop excision of the transformation zone (lletz)-conization for cervical dysplasia, two coagulation modes, spray versus forced coagulation, will be compared. the primary outcome of the study is time to complete hemostasis, secondary outcomes are intraoperative blood loss, postoperative pain, and postoperative bleeding complications.

intraoperative bleeding during large loop excision of the transformation zone (lletz)-conization can be achieved by two modes of electrocoagulation, spray coagulation and forced coagulation. spray coagulation is a superficial coagulation mode, whereas forced coagulation is a deep tissue coagulation mode. it is unknown, whether spray or forced coagulation is superior regarding intraoperative hemostasis and other outcome parameters such as postoperative bleeding and postoperative pain. therefore, the investigator designed a randomized clinical trial of 120 women undergoing large loop excision of the transformation zone (lletz)-conization for cervical dysplasia, comparing the two coagulation modes, spray coagulation and forced coagulation, the primary outcome of the study is time to complete hemostasis measured in seconds, secondary outcomes are intraoperative blood loss measured as difference in serum hemoglobin pre- and postoperatively, postoperative pain according to a 10 step vas scale, and postoperative bleeding complications, defined as necessity to intervene surgically for vaginal bleeding up to 14 days postoperatively. the study population consists of women undergoing lletz-conization for histologically proven cervical dysplasia. the study hypothesis states that the difference in the mean time until complete hemostais will be at least 1/3 shorter in women randomized to spray coagulation. with a study population of 120 women, this study has a power of \>80% to detect a difference of 1/3 of the mean coagulation time until complete hemostais based on an anticipated mean time of 85 seconds.

Eligibility criteria:
inclusion criteria: * histologically proven cervical dysplasia * colposcopy prior to lletz-conization * informed consent * no known hematologic disorder exclusion criteria: * significant language barrier * a personal history of lletz-conization

Keywords: conization lletz cervical dysplasia cervical intraepithelial neoplasia