Kornimate/medical-research-clean huggingface dataset:
study to assess the safety and effectiveness of beltavac® polymerized with cat dander

Conditions: Rhinoconjunctivitis With or Without Allergic Asthma

Summary: non-interventional study to assess the safety and effectiveness profile of a scit therapy with beltavac® polymerized with cat dander in allergic patients

this prospective open multi-centre non-interventional study assess the safety and effectiveness profile of the subcutaneous allergen-specific immunotherapy with beltavac® polymerized with cat dander allergic patients (children and adults) in routine medical care. patients receive a rush schedule administration every month for a year. they attend at least 5 study visits to inform about the adverse reactions, the self reported symptoms and the medication intake.

Eligibility criteria:
inclusion criteria: * patients of the age of 12 years and older suffering from a clinically relevant cat dander induced allergic rhinitis or rhinoconjunctivitis associated with or not with asthma * positive skin testing * positive serum-specific ige determination * informed consent exclusion criteria: * patients suffering from acute or chronic infections or inflammations * patients suffering from uncontrolled asthma * patients with a known autoimmune disease * patients with active malignant disease * patients requiring beta-blockers * patients having any contraindication for the use of adrenaline * patients with previous immunotherapy with this allergen or another allergen with cross-reaction * patients with immunotherapy treatment at the time of inclusion
nasal hfov versus nasal sippv in neonate following extubation: rct crossover study

Conditions: High-Frequency Ventilation; Intermittent Positive-Pressure Ventilation; Newborn Morbidity; Noninvasive Ventilation

Summary: mechanical ventilation was introduced to treat respiratory failure in preterm infants or sick neonates then improvements in survival (1,2). however, the complications from short or long term use of ventilation can result in unintended harm or burden (e.g., air leak syndrome, pneumonia, bronchopulmonary dysplasia, neurological injury, retinopathy of prematurity) (3,4). to reduce these risks, clinicians should aggressive extubated neonates as early as possible. respiratory (focus on blood gas as well as partial pressure co2 \[pco2\]) or extubation (focus on clinical condition as well as reintubation) failure was worrisome in pediatrician and parents if the neonate was reintubated owing to complete recovery of lung disease or inadequate respiratory drive. non-invasive ventilation (niv) was supported for primary respiratory support (initial mode before endotracheal intubation) or post-extubation. nasal continuous positive airway pressure (ncpap) was familiar to niv mode in neonatal respiratory support. nowadays, the new niv modalities are nasal intermittent synchronized positive pressure ventilation (nsippv) and nasal high frequency oscillation (nhfo). to increase the likelihood of ncpap success, other new modalities of niv may be interesting. from theory, nsippv and nhfo combines peak inspiratory pressure (pip) with synchrony and high-frequency oscillations without synchrony above cpap, respectively. from meta-analysis, nsippv and nhfo were statistically significant superior than ncpap both respiratory and extubation failure in neonate (5,6). the aim of our study was to investigate the efficacy of nhfov and nsippv for co2 clearance and reintubation rate after extubated neonates. the investigators hypothesized that nhfov mode would improve co2 clearance better than nsippv mode.

the primary outcome (pco2) was measured by crossover rct. the secondary outcome (reintubation within 7 days) was measured by paralleled rct.

Eligibility criteria:
inclusion criteria: * born in hospital and admit in nicu * the first endotracheal intubation and need niv if extubation * umbilical arterial catheterization to draw the blood gas * neonate has not been intervened from another rct study exclusion criteria: * major congenital anomalies or chromosomal abnormalities * neuromuscular diseases * upper respiratory tract abnormalities * suspected congenital lung diseases or pulmonary hypoplasia * need for surgery known before the first extubation * grade iv intraventricular hemorrhage occurring before the first extubation * palliative care * parents' decision not to participate

Keywords: nasal high-frequency oscillation nasal synchronized intermittent positive pressure respiratory failure extubation failure
tolerability of suprascapular and median nerve blocks for the treatment of shoulder-hand syndrome

Conditions: Shoulder Hand Syndrome; Complex Regional Pain Syndromes

Summary: shoulder-hand syndrome (shs) in stroke patients is painful and lowers quality of life. unfortunately, the cause of shs is not known, diagnosing shs can be difficult, and treating it can be hard. recent research has shown that certain nerve blocks are good for treating shoulder pain for stroke patients, but no one has looked specifically as shs. investigators think that specific nerve blocks involving a shoulder nerve (the suprascapular, or ssc nerve) and a hand nerve (the median nerve) will be helpful in reducing shs pain. investigators will use ultrasound guidance to accurately inject these nerves. these injections have never been described for shs patients however, so investigators want to make sure people with shs can go through with the injections without too much pain or discomfort. that is, the investigators want to test the tolerance of these injections for people with shs. investigators are also hoping to better understand how consistent a set of diagnostic criteria, called the budapest criteria, are at diagnosing shs in order to be able to accurately diagnose this condition.


Eligibility criteria:
inclusion criteria: * subjects are required to be 18 years of age or older and have a presumptive diagnosis of shs post-stroke with a minimum visual analog scale of 40mm (greater than 40mm is considered moderate pain). exclusion criteria: * subjects will be excluded from the study if they have significant cognitive impairment (mini-mental state examination \ 180/110), septicemia, and brachial plexus injuries will be excluded. patients who are blind and deaf will also be excluded, as they will be unable to adequately complete the post-procedure survey and vas. patients on anticoagulation medications will also be excluded on a case-by-case basis and medications will be held prior to injection if required for safety. patients with inr \>1.5 will be excluded.

Keywords: suprascapular nerve block median nerve block crps shoulder hand syndrome
chewing gum test for the diagnosis of giant cell arteritis (horton's disease) - chewinghort

Conditions: Horton Disease

Summary: it is hypothesized that chewing-gums may be a useful test to unmask jaws intermittent claudication in order to enhance the diagnosis of giant cell arteritis (gca).

gca is the most common vasculitis. the diagnosis easily could be made in patients over 50 years old with headache, inflammatory belt pain, claudication of the jaws, scalp hyperesthesia, ophthalmological manifestations and an inflammatory syndrome. however, the clinical pictures could be less suggestive, hence diagnostic difficulties. some patients have only isolated inflammatory syndrome. to confirm the diagnosis, sometimes pet ct or temporal artery biopsy is used, but access to a pet ct is sometimes complex, biopsy of temporal arteries is only positive in about 70% cases. early diagnosis is important, however, to avoid irreversible complications, especially ophthalmological complications. one in six patients has definitive amaurosis, because of diagnosis delay. the current diagnostic delay is estimated on average at 9 weeks. jaw intermittent claudication probably has a very good positive predictive value and this clinical sign often carries conviction. patients with claudication of the jaws also have a greater visual risk. kuo reports two observations of patients with claudication of the jaws revealed by the "chewing gum test" after 2 minutes of chewing. it is therefore proposed to perform a chewing gum test to assess the sensitivity and specificity of this test, compared to the interview. once the test is done, the study is completed for the patient.

Eligibility criteria:
inclusion criteria: * group 1 * any patient suspected of having gca, that is to say in practice patients in whom a doctor plans a doppler ultrasound of temporal arteries or a temporal arteritis biopsy or an imagery (angio-ct, angio-mri, pet- to scan * patient over 50 years old * patient able to chew a chewing gum for 4 minutes group 2 * patients free from gca * age matched (± 3 years) * patient able to chew a chewing gum for 4 minutes exclusion criteria: * group 1 * patients known to have a temporomandibular joint pathology * patients who started corticosteroid therapy group 2 * patients known to have temporomandibular joint pathology * patients who started corticosteroid therapy
a validation study of nitroglycerin induced acute drop of pd/pa (ntg-pd/pa) in clinical practice

Conditions: Hypotension Symptomatic; Ischemic Heart Disease

Summary: hyperemia with adenosine was an elemental process in ffr examination. adenosine injection will induce some discomfort, and increase cost expenditure. nitroglycerine will induce an acute drop of pd/pa, and this lowest pd/pa was determined as ntg-pd/pa. ntg-pd/pa has a linear relationship with ffr value and has a good diagnostic accuracy to predict ffr≤0.80 in our recent study. there is only one prospective study report on the relationship between ntg-pd/pa and ffr. in this study, we aim to evaluate the safety of ntg-pd/pa, the repeatability and dose-response of this novel index. furthermore, we will investigate the diagnostic accuracy of ntg-pd/pa, with ffr≤0.8 and resting full-cycle ratio≤0.89 as ischemic threshold respectively.

fractional flow reserve (ffr) is defined as the ratio of mean distal pressure (distal to the target lesion, pd）to mean proximal pressure (aortic pressure, pa) in the coronary artery(pd/pa) while the maximal hyperemic flow is achieved. nowadays, ffr-guided pci is highly recommended for the assessment of physiologic ischemia in intermediate coronary lesions. however, hyperemia with adenosine was an elemental process in ffr examination. adenosine injection will induce some discomfort, and increase cost expenditure. based on the clinical and physiologic outcome study, a lot of non-hyperemic indexes had been proposed, and adenosine injection could be waived. whereas, these novel physiologic indexes are limited to the proprietary software of each vendor, curtailing clinical application. intracoronary nitroglycerin injection was needed before each ffr assessment. nitroglycerine will induce an acute drop of pd/pa, and this lowest pd/pa was determined as ntg-pd/pa. ntg-pd/pa has a linear relationship with ffr value and has a good diagnostic accuracy to predict ffr≤0.80 in our recent study. there is only one prospective study report on the relationship between ntg-pd/pa and ffr. in this study, we aim to evaluate the safety of ntg-pd/pa, the repeatability and dose-response of this novel index. furthermore, we will investigate the diagnostic accuracy of ntg-pd/pa, with ffr≤0.8 and resting full-cycle ratio≤0.89 as ischemic threshold respectively.

Eligibility criteria:
inclusion criteria: * eligible for ffr examination exclusion criteria: * hypersensitivity to adenosine or nitroglycerine * severe valvular aortic stenosis * resting heart rate less than 50 beats per minutes * systolic blood pressure less than 100 mmhg or diastolic blood pressure less than 40 mmhg * exposure to pde-5 inhibitors within 48 hours. * recent intracranial hemorrhage or brain injury

Keywords: ntg-pd/pa, fractional flow reserve, adenosine
the role of carotid flow time-based fluid administration in caesarean section

Conditions: Spinal Anesthesia; Cesarean Section

Summary: it has been reported that corrected carotid flow time (ftc) may indicate the responsiveness of spontaneously breathing patients to fluid therapy. the primary objective of the study is to determine the effect of fluid preload applied to patients with preanesthetic ftc values below the cut-off value on the incidence of hypotension in cesarean section (c/s) surgery. pregnant women who underwent cesarean section under spinal anesthesia were included in this prospective study. in the preoperative care unit, patients were assigned to two groups according to their baseline ftc values. patients with baseline ftc \ 327 ms. on the other hand, patients with baseline ftc \> 327 ms were assigned to the second group, and preload fluid was not administered to these patients. intraoperative hemodynamic data were recorded for each patient.


Eligibility criteria:
inclusion criteria: * 20-40 years of age pregnant women * american society of anesthesiologists (asa) physical status-ii patients * uncomplicated, singleton, term pregnancy * elective c/s surgery exclusion criteria: * placental disorders * gestational hypertensive disorders * morbid obesity (bmi\>39 kg/m2) * carotid stenosis more than 50% * baseline sap more than 160 mmhg * arrhythmia * history of cardiovascular or cerebrovascular disease, and chronic kidney disease (estimated glomerular filtration rate \<60 ml/min/1.73 m2) * emergency surgery

Keywords: cesarean section carotid flow time preload fluid hypotension spinal anesthesia
tissue doppler imaging (tdi) versus electrocardiography (ecg) interventricular pacing delay optimization in cardiac resynchronization therapy (crt)

Conditions: Heart Failure; Cardiac Resynchronization Therapy

Summary: the aim of this study was to compare the response to cardiac resynchronization therapy when the interventricular pacing interval was optimized by tissue doppler imaging (tdi) to response when it was optimized following qrs width criteria.


Eligibility criteria:
inclusion criteria: * patients submitted to de novo implant due to conventional cardiac resynchronization therapy indications. exclusion criteria: -
evaluation of interprofessional relations between primary care and hospital centers in the experimentation of medical cannabis in france carried out by the ansm (ecipcanna)

Conditions: Medical Cannabis

Summary: an observational study to explore inter-professional relations and perceptions around the experimentation of medical cannabis, conducted by the french national agency for safety and health. the study aims to identify the barriers and facilitators to prescribing and dispensing medical cannabis and to analyse healthcare professionals' perceptions of medical cannabis in france. using a qualitative method based on semi-directed interviews and focus groups, the study will involve hospital physicians, general practitioners, and community and hospital pharmacists participating in the the french national agency for safety and health experiment. the primary objective is to understand the dynamics between health professionals involved in the medical cannabis programme, while secondary objectives include proposing strategies to overcome barriers to the provision of medical cannabis.


Eligibility criteria:
inclusion criteria: * healthcare professional participating in the experiment conducted by the the french national agency for safety and health: hospital doctor, general practitioner, community pharmacist, or hospital pharmacist * non-opposition exclusion criteria: * refusal of participation by hospital doctor, general practitioner, community pharmacist, or hospital pharmacist

Keywords: cannabis for medical use outpatient medicine prescription pharmacy primary care
age, risk factors for cvd and cognitive functioning

Conditions: Cardiovascular Diseases; Heart Diseases; Neurologic Manifestations

Summary: to relate cardiovascular disease (chd) risk factors to cognitive performance among middle-aged and elderly men and women over a 10 year longitudinal study period.

background: the framingham heart study is a major epidemiological investigation of prospective relationships between risk factors for the development of cardiovascular disease (cvd risk factors) and cvd risk factor outcomes. the framingham study and other large, prospective studies have resulted in an extensive literature on the impact of cvd risk factors (including age) and cvd outcomes. comparatively, there have been many fewer studies of the impact of cvd risk factors on cognitive functioning, and possibly no studies of the effect of objectively measured, competing risk factors on cognitive functioning. design narrative: dr. elias and colleagues used cardiovascular risk factor data from the framingham heart study (n= 2,123) in a prospective design allowing them to relate cvd risk factors (including age and gender) to two outcome measures: (1) level of cognitive performance and (2) change in cognitive performance over a 10 year longitudinal study period. the overall goals were to determine the best multivariate combination of biological and psychosocial risk factors for the prediction of lowered cognitive ability in middle-aged and elderly men and women, and to evaluate the relative impact of age, gender, and other biological and psychosocial risk factors on cognitive functioning. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
a family intervention for delirium prevention

Conditions: Delirium

Summary: to address the feasibility of implementing a randomized, educational intervention to prevent delirium, directed at family members of hospitalized older (70 years of age or older) medical in-patients. specifically rates of recruitment and acceptance rates of such an intervention to family members will be assessed. an estimate of the effect size of this intervention will also be calculated. this is a pilot study. the investigators hypothesize that this intervention will be feasible and agreeable to family members to perform, with acceptance rates exceeding 80%.

in a recent study in chile, investigators randomized family members of admitted patients to an educational intervention to prevent delirium. family members actively participated in a non-pharmacological intervention to prevent delirium. this has not been done in a north american environment, with different cultural and climactic factors. this study will be a randomized controlled trial (pilot study) involving family members. family members will be randomized to a control group or an educational intervention. the control group will receive a general brochure, outlining general health information published by the ministry of health. the intervention group will receive a specific brochure on details around delirium (what it is and how to prevent it), and then a brief educational session comprising a didactic session and to address any questions. this pilot study will examine the feasibility of doing this kind of intervention in a north american environment. the family-based intervention is similar to what was done in the chilean study. it involves six elements including the educational session. the five other elements include: 1) family being present for extended periods (at least 5 hours if possible); 2) engaging in conversation with study patients for re-orientation to current time and current events; 3) avoiding sensory deprivation (ensuring hearing or visual aids and dentures are available as needed; 4) providing familiar objects to patients; 5) provision of a clock and calendar to the patient. the intervention brochure is similar to what was provided to family members as part of the original chilean study (kindly provided to the principal investigator, m. dasgupta, by the lead author of the chilean study, dr. f.t. martinez).

Eligibility criteria:
inclusion criteria: * age 70 years or older * residing in the community * admitted to a general medical unit at the london health sciences center, university campus * having a willing and interested english-speaking family member * not delirious on admission * able to communicate in english exclusion criteria: * terminal condition * delirious on admission * advanced dementia * admission to the icu (or transfer to the icu within one week of admission)

Keywords: delirium hospitalized elderly
real-world evidence study of xen in chinese patients with refractory glaucoma

Conditions: Refractory Glaucoma

Summary: real-world evidence study to assess the safety and effectiveness of xen® glaucoma treatment system in chinese patients with refractory glaucoma. participants will be (prospective) or have already been (retrospective) implanted with xen via specific urgent medical need.


Eligibility criteria:
inclusion criteria: * patients with refractory glaucomas, including cases where previous surgical treatment has failed, cases of poag, and pseudoexfoliative or pigmentary glaucoma with open angles that are unresponsive to maximum tolerated medical therapy exclusion criteria: * angle closure glaucoma where angle has not been surgically opened * previous glaucoma shunt/valve in the target quadrant * presence of conjunctival scarring, prior conjunctival surgery or other conjunctival pathologies (eg, pterygium) in the target quadrant * active inflammation (eg, blepharitis, conjunctivitis, keratitis, uveitis) * active iris neovascularization or neovascularization of the iris within six months of the surgical date * anterior chamber intraocular lens * presence of intraocular silicone oil * vitreous present in the anterior chamber
motor imagery training football players with anterior cruciate ligament repair

Conditions: Anterior Cruciate Ligament Injuries

Summary: volunteer participants who have undergone anterior cruciate ligament surgery at bursa çekirge state hospital and meet the inclusion criteria will be included in the study. the study will select a sample group from the universe using the probability sampling method (simple random sampling). participants will be divided into 2 groups: conventional physiotherapy + kinesthetic motor imagery training group and conventional physiotherapy group with randomization software (https://www.randomizer.org/). conventional physiotherapy practices created by the physician will be applied by physiotherapists working in the hospital. knee functions will be evaluated with the ikdc scale, reaction time will be assessed with video recording supported by the kinovea program, kinesiophobia will be assessed with the tampa kinesiophobia scale, and finally, autonomic functions will be evaluated with the polar device. measurements will be repeated after 6 weeks of interventions.


Eligibility criteria:
inclusion criteria: * individuals with anterior cruciate ligament repair, * individuals who have no experience in this type of training, * not having any vision, hearing, or speech problems that would prevent the tests from being performed. * individuals who agree to the purposes of this study and to participate voluntarily. exclusion criteria: * have previous experience in motor imagery techniques or training, * having any orthopedic problem that prevents walking, * having a history of neurological disease, * people being treated with any medication that affects the central nervous system
effects of systemic lidocaine on postoperative quality of recovery after robot-assisted thyroidectomy

Conditions: Thyroid Cancer

Summary: systemic lidocaine infusion may improve the patients' recovery quality and chronic post surgical pain after robot-assisted thyroidectomy


Eligibility criteria:
inclusion criteria: * age between 20-65 * asa class i and ii * thyroid cancer patients who are scheduled for elective robot-assisted thyroidectomy exclusion criteria: * allergy to local anesthetics or contraindication to use of lidocaine * pregnancy * severe cardiovascular disease * renal failure * liver failure * neurologic and psychologic disease * chronic treatment with analgesics

Keywords: systemic lidocaine, intravenous lidocaine infusion, postoperative pain, quality of recovery, robot-assisted thyroidectomy, thyroid cancer