Kornimate/medical-research-clean huggingface dataset:
effect of virtual reality glasses used during splint application on children's pain and anxiety levels.

Conditions: Pain, Acute; Anxiety Acute; Fractures, Bone

Summary: the study in order to evaluate the effect of virtual reality glasses during splint in children on pain and anxiety due to the procedure.

the study was carried out as a randomized controlled experimental study in order to evaluate the effect of virtual reality glasses during splint in children aged 6-12 years on pain and anxiety due to the procedure. the sample of the research consisted of 80 childrens who came to karabuk university training and research hospital orthopedic policlinic and emergency between 1 may and 31 october 2021 for the splint application. in the study, two groups consisted of experimental group (n=40) and control group (n=40) were determined. the "participant information form", the "wong baker pain scale", the "state anxiety inventory for children", virtual reality glasses and pulse oximeter were used to collect data. the pain, anxiety and vital signs of the children in the experimental and control groups were recorded before, during and after the splint. the video chosen by the children in the experimental group was shown with virtual reality glasses during the splint application. in the control group a video wasn't shown during the splint application. chi square, mann whitney u, bonferroni and friedman tests were used in the analysis of data.

Eligibility criteria:
inclusion criteria: * the child should be between the ages of 6 and 12 age old. * acceptance of the research and giving written consent by the family and the child. * ability of the family and child to speak turkish. * the child should not wear glasses. * the child should be at a cognitive level able to choose videos. exclusion criteria: * the child should have chronic diseases. * the child should take analgesics with in the last 24 hours. * the child should have physical, mental and neurological disabilities. * the child has a febrile illness. * fainting of the child during the procedure.

Keywords: anxiety child fracture nurse pain splint virtual reality glasses
research on individualized treatment for alcoholism

Conditions: Alcohol Dependence

Summary: the purpose of this study was to compare the effects of two psychosocial treatments that differed in scope and intensity (broad spectrum treatment and motivational enhancement treatment) combined with 3 or 6 months of treatment with naltrexone on alcohol drinking behaviors in alcohol dependent patients.


Eligibility criteria:
inclusion criteria: * men and women between the ages of 21-65 * current dsm-iv diagnosis of alcohol dependence * abstinent for a minimum of 3 and maximum of 21 days prior to treatment initiation * able to participate in an 18-month outpatient study * live within a one hour or less commute to fairbanks * fluent in english * women of child-bearing potential must have a negative pregnancy test and use effective contraceptive methods. * score as contemplators or greater on the readiness for change scale exclusion criteria: * severe hepatic disease (gggt, sgot or other liver functions greater than 4 times normal) * opiate use (for any reason) in the last 14 days or a history of opioid dependence in the past year * pregnant or lactating females or those unwilling to use birth control * inability, according to the opinion of the interviewer, to follow medication instructions and safety precautions * comorbid substance dependence (but not abuse) diagnosis in the past 6 months, excluding nicotine or marijuana dependence * concomitant use of medications intended to decrease drinking (e.g. disulfiram) * meeting current dsm criteria for bipolar disorder, schizophrenia, bulimia/anorexia, dementia, major depression

Keywords: alcoholism naltrexone motivational enhancement therapy
a trial in recombinant human prourokinase to treat acute pulmonary embolism

Conditions: Acute Pulmonary Embolism

Summary: this trial is being conducted to assess the efficacy and safety of recombinant human prourokinase in the acute pulmonary embolism.


Eligibility criteria:
inclusion criteria: 1. aged 18-75 years（include the critical value）and 2. high-risk pe or medium high-risk pe and 3. pe symptom duration ≤14 days and 4. plt≥100×10\^9/l，alt and ast≤2.5uln，tbil\<uln，cr within the normal range and 5. informed consent can be obtained from subject or legally authorized representative exclusion criteria: 1. hemorrhagic or unexplained stroke history 2. ischemic stroke or transient ischemic attack (tia) within 6 months 3. the existence of the central nervous system injury or tumor 4. severe trauma，major surgery or head injury within 3 weeks 5. active bleeding within 1 month 6. clinician deems high-risk for bleeding 7. using anticoagulants (after a washout period can be randomized) 8. pregnancy or delivery within 1 week 9. vascular puncture which can not be oppressed 10. cardiopulmonary resuscitation within 10 days 11. systolic blood pressure above 180 mmhg or diastolic blood pressure above 100mmhg 12. severe liver dysfunction 13. infective endocarditis 14. arterial aneurysm or arteriovenous malformation or suspected aortic dissection 15. left atrial thrombus 16. neurosurgery or eye surgery within 1 month 17. hemorrhagic diabetic retinopathy 18. serious cardiac insufficiency 19. ventricular arrhythmias 20. known allergic to prourokinase，urokinase，recombinant tissue-type plasminogen activator，contrast agent or any drug in the trial 21. do not allow for 30 days' study 22. any disease or condition is not suitable for intravenous thrombolysis 23. lactating women or plan to pregnant women during the trial，or don't want to during the study period using effective contraception or abstinence of male and female patients with possibility of fertility 24. clinician thinks patient doesn't fit to participate in the test of other diseases or conditions
laparoscopic splenectomy in children

Conditions: Laparoscopic Splenectomy; Children; Benign Blood Diseases

Summary: laparoscopic splenectomy (ls) gained popularity since it has been described for the first-time during nineties of past century. it has become "golden method" for splenectomy in all ages including children

background: laparoscopic splenectomy (ls) gained popularity during the last years in pediatric age group. benign hematological diseases represent the main indications of that procedure. there are some score systems of difficulty of the technique but they are for adult patients. the aim is to develop a prognostic score system of ls in children with benign hematological diseases. methods: ls was performed in all children with benign hematological diseases. ls was done by the same team. they operated children in lateral decubitus position. the control of pedicle was achieved using bipolar sealing devices, polymer clips or endoscopic linear staplers. preoperative, operative, and postoperative data were recorded and analyzed. children were divided into two groups a and b according to the development of complications.

Eligibility criteria:
inclusion criteria: * children with benign hematological diseases exclusion criteria: * malignant hematological diseases

Keywords: laparoscopic splenectomy, children prognostic score benign hematological diseases
evaluation of a clinical decision support system for anemia management in pre-operative care

Conditions: Decision Support Systems; Anemia

Summary: anemia need to be diagnosed and treated, following several guidelines. however, the complexity of these recommendations leads to low compliance and to unnecessary and harmful per- and postoperative blood transfusion. in order to improve practices and regarding the complexity of the guidelines, the latest european consensus conference recommends the use of decision support systems for the management of preoperative anemia.

the world health organization defines anemia as a hemoglobin level of less than 13 g/dl in adult men and less than 12 g/dl in women. the cause of these anemias is most often deficient with 17% iron deficiency. this deficiency is related to age, inflammatory diseases, blood loss, and absorption disorders mainly. anemia must be diagnosed preoperatively and treated. to reduce transfusion in the perioperative period there are various possibilities: increase of the preoperative erythrocyte mass, reduction of losses, use of the blood that has been applied. the impact of these preoperative strategies can be considerable. in their work, beattie and al demonstrates that transfusion is associated with an increase in mortality at 90 days, proportional to the volume transfused, with certainly a higher risk in fragile subjects. more recently, an american registry of more than 220,000 patients showed that 30% had preoperative anemia. this anemia not only significantly increased mortality, but all causes of comorbidity were aggravated in an anemic patient. however, the complexity of these recommendations leads to low compliance and to unnecessary and harmful per- and postoperative blood transfusion. in order to improve practices and regarding the complexity of the guidelines, the latest european consensus conference recommends the use of decision support systems for the management of preoperative anemia.

Eligibility criteria:
inclusion criteria: * anesthesiologist: anesthesiologists, resident/fellow physician anesthesiologists. exclusion criteria: * unfinished questionnaire.

Keywords: clinical decision support systems patient blood management preoperative anemia
evaluation of the effectiveness of two marketed multi-purpose solutions for silicone hydrogel contact lenses - study 1

Conditions: Myopia; Hyperopia; Contact Lens Comfort

Summary: the purpose of this study was to evaluate the performance of opti-free® puremoist® multi-purpose disinfecting solution (mpds) compared to biotrue™ multipurpose solution (mps) in silicone hydrogel contact lens wearers.

in this 2-period crossover study, eligible participants were randomized to either opti-free® puremoist® multi-purpose disinfecting solution or biotrue™ multipurpose solution in period 1 for use with their habitual contact lenses, after which they switched to the alternate solution in period 2. each period was 30 days in length. a 2-day washout period during which participants refrained from using a multi-purpose contact lens solution preceded period 1 and period 2.

Eligibility criteria:
inclusion criteria: * wear single vision sphere silicone hydrogel contact lenses (coopervision™ biofinity®, alcon® air optix® aqua, bausch+lomb® purevision™ or acuvue® oasys™) on a daily wear basis (a minimum of 8 hours per day, 5 days a week) for at least one month prior to visit 1; * willing to wear lenses on a daily wear basis (a minimum of 8 hours per day, 5 days a week) for the duration of the study, and wear lenses for 16 hours on two days during the study; * must have habitually used a biguanide preserved multi-purpose solution (other than biotrue) for at least 30 days prior to visit 1; * vision correctable to 20/30 snellen (feet) or better in each eye at distance with pre-study contact lenses at visit 1; * have access, capability and willingness to review and answer text messages; * read, sign, and date irb/iec approved informed consent and privacy document before enrollment; * willing to follow the study procedures and visit schedule; * other protocol-defined inclusion criteria may apply. exclusion criteria: * need to wear lenses on an extended wear (i.e. overnight) basis during the study; * known sensitivity or intolerance to biguanide, polyquaternium-1 (polyquad), or aldox preserved lens care products; * monocular (only one eye with functional vision) or fit with only one lens; * wearing toric or multifocal contact lenses or fit with monovision; * use of additional lens care products other than a biguanide preserved multipurpose solution such as daily or enzyme cleaners within the one week prior to visit 1; * use of topical ocular over-the-counter (otc) or prescribed topical ocular medications, with the exception of rewetting drops, within 7 days prior to visit 1; * abnormal ocular condition observed during the visit 1 slit-lamp examination; * current or history of ocular infections or severe inflammation within 6 months prior to visit 1; * ocular surgery within the 12 months prior to visit 1; * participation in any other clinical trial within 30 days of enrollment; * other protocol-defined exclusion criteria may apply.

Keywords: multi-purpose solution silicone hydrogel contact lenses comfort opti-free biotrue
a twelve week safety and efficacy study in rosacea

Conditions: Papulopustular Rosacea

Summary: the purpose of this study is to evaluate th safety and efficacy of one-daily topical application of cls001 low, mid and high dose compared to vehicle gel in subjects with papulopustular rosacea.


Eligibility criteria:
inclusion criteria: * diagnosis of papulopustular rosacea (at least 15 lesions) exclusion criteria: * nodular rosacea or subtype 3 * clinically significant abnormal findings that would interfere with study objectives

Keywords: rosacea
anesthesia-handover checklist and perioperative outcomes in elderly

Conditions: Elderly Patients; Major Surgery; Anesthesia; Adverse Effect; Prevention; Postoperative Complications

Summary: with the increasing number of surgical cases, intraoperative handover of anesthesia care is common and inevitable. verbal handover from one anesthesiologist to another during surgery are being used in many hospitals. however, verbal handover is often an informal, unstructured process during which omissions and errors can occur. it is possible that an improved anesthesia handover may reduce the related adverse events. this study aims to test the hypothesis that use of a well-designed, structured handover-checklist to improve handover quality may decrease the occurrence of postoperative complications in elderly patients undergoing major noncardiac surgery.

it was estimated that more than 9 million patients undergo surgery with a complete anesthesia handover each year worldwide. verbal handover from one anesthesiologist to another during surgery are being used in many hospitals; and there is no unified patient handover guideline at present. it is well recognized that the transfer-of-care is a point of vulnerability where valuable patient information can be distorted and omitted. a previous study of the investigators showed that handover of anesthesia care was associated with a higher risk of delirium in elderly patients after major noncardiac surgery. the world health organization has included communication during patient care handovers among its top 5 patient safety initiatives. it is possible that an improved anesthesia-handover protocol may reduce the related adverse events. many efforts have performed to optimize handover processes. however, handover quality between anesthesiologists has rarely been investigated. the investigators hypothesize that a well-designed, structured handover-checklist will improve handover quality and reduce the occurrence of postoperative complications.

Eligibility criteria:
inclusion criteria: 1. elderly patients (aged 65 years and over); 2. scheduled to undergo major non-cardiac surgery with an expected duration of at least 2 hours; 3. requirement of complete handover between anesthesiologists during surgery (initial anesthesiologist no longer returns). exclusion criteria: 1. preoperative history of schizophrenia, epilepsy, parkinsonism or myasthenia gravis; 2. inability to communicate before surgery (coma, profound dementia or language barrier); 3. craniocerebral injury or neurosurgery; 4. severe liver dysfunction (child-pugh grade c), severe renal dysfunction (requiring dialysis), or expected survival of \<24 hours.

Keywords: elderly patients major surgery anesthesia handover handover checklist postoperative complications
implementation of lung cancer screening in the first line zone of zora (flanders), using a low dose ct-scan

Conditions: Lung Cancer, Nonsmall Cell; Lung Cancer; Smoking Cessation; Lung Cancer, Small Cell

Summary: the goal of this clinical trial is to implement lung cancer screening in a targeted high-risk population of heavy (ex-)smokers in flanders (belgium). this implementation study will investigate the participation rate of eligible high risk (ex-)smokers in the first line zone south east region of antwerp (zora) in a ldct screening program, combined with smoking cessation.

a four year prospective non-randomized feasibility implementation study for lung cancer screening in a targeted high-risk population of heavy (ex-)smokers by low-dose ct, combined with a smoking cessation intervention. it will be coordinated by a consortium of researchers from uza and uantwerpen. lung cancer (lc) remains the leading cause of cancer mortality, worldwide and in belgium. prevention and early detection are considered the cornerstones to increase the chances of successful treatment and improved outcomes. there is strong scientific evidence that screening for lung cancer through an annual low-dose ct scan (ldct) in a high-risk population of (ex-)smokers significantly reduces lung cancer mortality and is cost-effective. this implementation study will investigate the participation rate of eligible high risk (ex-)smokers in the first line zone (elz) south east region of antwerp (zora) in a ldct screening program, combined with smoking cessation. besides, other indicators of compliance, quality and turn-around-time will be estimated. it will give insights in the feasibility and potential challenges of implementing a ldct lung cancer screening program in our region. this implementation project is in line with the european commission council recommendation of december 2022 to explore the feasibility and effectiveness of ldct in a high-risk population. findings from this study will contribute valuable evidence for policymakers and stakeholders. furthermore, an implementation pilot is a prerequisite for a future high-quality population-based screening program.

Eligibility criteria:
inclusion criteria: the target population consists of all adult inhabitants from the following municipalities of the elz zora: mortsel (2640), edegem (2650), boechout (2530), kontich (2550), lint (2547), hove (2540), and having a (tba) % risk of developing an incidental lung cancer in the following 6 years (calculated a by risk prediction model) 1. males and females 2. 55 -74 years old 3. fitness for any kind of curative therapy for lung cancer 4. absence of prior (lung) cancer in the 5 preceding years (excluding skin basal cell carcinoma and early stage cervical cancer) 5. having a gp or related trusted health care provider exclusion criteria: 1. participant may not have any symptoms (cough, pain when breathing in...) 2. body weight \>140 kg in view of the maximum charge of the ct-scan table 3. the (rare) hereditary li-fraumeni syndrome which gives the carriers an excess risk of x-ray induced oncogenesis

Keywords: lung cancer screening lung cancer smoking cessation
intrathecal stem cells in brain injury

Conditions: Hypoxia-Ischemia, Cerebral; Cerebral Palsy

Summary: the purpose of this study is to determine whether the plasticity of autologous intrathecal hematopoietic cells would improve the neurologic evolution of the pediatric patients with hypoxic/ischemic brain injury.

there is accumulating evidence that shows that the placement of hematopoietic cells in the brain may increase growth-enhancing factors of axons and generate active neurons in the receptor. it has been found that after introducing hematopoietic cells in the subarachnoid space of the spinal cord, these cells may be transported through the cerebrospinal fluid and can be deliver more efficiently to the injured area, when compared to the intravenous route. patients will be stimulated 4 times and then harvest the bone marrow. bone marrow will be processed in order to obtain hematopoietic cells (cd34+) and minimize the erythrocytes amount. a inoculum of 5 to 10ml of stem cells will be infused intrathecally. patients will be evaluated with the "battelle developmental inventory" before the procedure and one and six months after that. an mri will be performed before the procedure and six months after that.

Eligibility criteria:
inclusion criteria: * patients with hypoxic/ischemic brain injury, with an between 1 month and 18 years, regardless the age at the time of injury, time post-injury, or previously received therapies, different from ours. exclusion criteria: * patients with neurodegenerative or autoimmune diseases. * patients with active infection in any organ or tissue at the time of entering the study, the onset of stimulation with g-csf or at the procedure. * patients who do not sign the informed consent form. elimination criteria * patients with severe meningeal abnormalities at the time of procedure. * patients who did not attend subsequent assessments 30 and 180 days after the procedure. * patients who die from causes related to neurological disease within 180 days after procedure. * patients who are diagnosed with neurodegenerative or autoimmune diseases after the procedure. * patients who do not bear the proper stimulation process with granulocyte colony stimulating factor (g-csf), either by misapplication, lack thereof, or severe adverse drug reaction. * patients choosing to leave the study.

Keywords: hypoxia ischemia brain children cerebral palsy
inferior vena cava collapsibility index assessment in predicting post spinal anaesthesia hypotension in patients undergoing arthroscopic knee surgeries.

Conditions: Post Spinal Anaesthesia Hypotension; Inferior Vena Cava Collapsibility Index

Summary: the aim of this study was to evaluate the role of inferior vena cava collapsibility index assessment in predicting post spinal anaesthesia hypotension in patients undergoing arthroscopic knee surgeries.

prospective cohort study conducted in ain shams university hospitals.

Eligibility criteria:
inclusion criteria: * patients: american society of anesthesiologists physical status (asa) i to ii undergoing arthroscopic knee surgeries under spinal anaesthesia. * both sexes. * aged 30 to 60 years. * body mass index \<35 kg/m2 exclusion criteria: * patients' refusal of procedure or participation in the study. * patients with contraindication to spinal anaesthesia. * patients with severe cardiovascular or pulmonary disease. * patients with pre-procedural hypotension (systolic arterial pressure less than 90 mmhg and/or mean arterial pressure less than 60 mmhg).

Keywords: inferior vena cava collapsibility index post spinal anaesthesia hypotension arthroscopic knee surgeries