Kornimate/medical-research-clean huggingface dataset:
magnesium sulfate versus placebo for tocolysis in pprom

Conditions: Preterm Premature Rupture of Membranes

Summary: study compares the outcomes of women between 26 and 32 wks gestation with rupture of membranes. women randomized to receive tocolysis with magnesium sulfate x 48 hrs or placebo of saline iv x 48 hrs. antibiotics and antenatal steroids given to both groups.

the majority of studies of the effectiveness of tocolysis with pprom were in the 1980s prior to the commmon usage of antenatal steroids and prophylactic maternal antibiotics. in most studies, tocolysis was not attempted prior to the onset of labor in this group of women. the acog practice bulletin of june 1998 concedes that the recommendation of tocolysis to permit administration of steroids and maternal antibiotics is based primarily upon consensus, not consistent scientific evidence. the purpose of this study, which will randomize 128 subjects to tocolysis or no tocolysis, is to prospectively assess whether short term (48 hr) tocolysis affords benefit to women and babies between 26 and 32 weeks gestation with pprom. subjects will be enrolled at 1-2 high risk hospitals in chattanooga and knoxville. all english and spanish speaking women 18-45 years with pprom and cervical dilation \ 6 hours tocolysis at time of admission will be excluded. both groups of women will receive continuous fetal monitoring, antibiotics, and antenatal steroids (if not previously administered). both groups will be evaluated every 2-4 hours for fetal and maternal well being. both groups will receive ivf at 125cc/hr, and the treatment group will be loaded with 4 grams of magnesium sulfate and receive maintainence dose of 2 grams/hr x 48 hrs.

Eligibility criteria:
inclusion criteria: * english or spanish speaking * preterm premature rupture of membranes * 26 - 32.6 weeks gestation * cervical dilation \</= 4 cm exclusion criteria: * suspected intrauterine or intraamniotic infection * \> 6 hours of tocolysis prior to admission * positive fetal lung maturity

Keywords: short term tocolysis preterm premature rupture of membranes
assessing psychotherapy outcome with feedback

Conditions: Individual Psychiatric Disorder; Couple Dysfunction; Family Dysfunction

Summary: this study is a comparison of client outcomes in two different types of psychotherapy treatment. in one condition clients will receive treatment-as-usual (tau); the therapy that they would normally receive. in the other condition clients will receive treatment-as-usual but in addition their therapist will have access to empirical feedback on client progress. clients in the feedback condition will fill out weekly online questionnaires, and their therapists will have access to a website that feeds back the results of these questionnaires. the purpose of the study is to understand the impact of providing such feedback to therapists. participating therapists at 4 sites will offer all of their clients the opportunity to participate, and participating clients will be randomly assigned to either condition. this should result in a representative sample of client seeking treatment at these 4 chicago-area clinics.


Eligibility criteria:
inclusion criteria: * client seeks therapy at one of the 4 participating sites * for individual therapy: client must consent and complete pre-test battery before the first therapy session * for couple therapy: both clients must consent and complete pre-test battery before the first therapy session * for family therapy: at least one client must consent and complete pre-test battery before the first therapy session * clients must be 12 years of age or older * clients must be able to read (english or spanish) at a 6th grade level exclusion criteria: * clients under 12 years of age * clients incapable of reading at a 6th grade level * clients who are blind, or are have sufficiently impaired sight as to be unable to read the questions on the web portal
effect of granisetron on usage of sympathomimetics during caesarean section

Conditions: Hypotension; Cesarean Section Complications

Summary: the aim of the present study is to quantify the dose and usage of sympathomimetics used in caesarean section.

recent metaanalysis showed significantly reduced hypotension and bradycardia in patients undergoing caesarean section in spinal anesthesia when 5-hydroxytryptamine 3 receptor antagonists were used prophylactically. due to this fact in our clinic the standard procedure was changed. all patients for caesarean section receive granisetron before spinal anesthesia. the aim of the present study is to evaluate the usage and dose of sympathomimetics during spinal anesthesia. therefore the investigators will evaluate approximately 120 participants who received granisetron and 120 participants who did not receive 5-hydroxytryptamine 3 receptor antagonists.

Eligibility criteria:
inclusion criteria: * caesarean section in spinal anesthesia exclusion criteria: * withdrawal * incomplete documentation

Keywords: serotonin antagonists sympathomimetics
a trial investigating the efficacy and safety of flexible vs. fixed dosing and simple vs. stepwise titration with once daily (od) insulin degludec in inadequately treated subjects with type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in asia. the aim of the trial is to investigate the efficacy and safety of flexible versus fixed dosing and simple versus stepwise titration with od insulin degludec in inadequately treated subjects with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * current treatment with iglar (insulin glargine) with or without oads (oral antidiabetic drug). all antidiabetic treatments should have been on-going for at least 12 weeks prior to randomisation, and doses of oads should have been stable in this period of time. - please note that a maximum of 3 oads are allowed during this trial: metformin, sulphonylurea (su)/glinides, dipeptidyl peptidase 4 (dpp-iv) inhibitors, alfa-glucosidaseinhibitors or pioglitazone. * diagnosis of t2dm (type 2 diabetes mellitus) at the discretion of the investigator for at least 26 weeks prior to visit 1 (screening visit) * hba1c 7.0-9.5% (both inclusive) by central laboratory analysis * body mass index (bmi) equal to or below 35 kg/m\^2 exclusion criteria: * any chronic disorder or severe disease which, in the opinion of the investigator might jeopardise subject's safety or compliance with the protocol * stroke; decompensated heart failure new york heart association (nyha) class iii or iv; myocardial infarction; unstable angina pectoris; or coronary arterial bypass graft or angioplasty; all within the last 26 weeks prior to visit 1 (screening visit) * impaired renal function, defined as serum-creatinine higher than or equal to 1.4 mg/dl for males and higher than or equal to 1.3 mg/dl for females * current or past (within the last 5 years) malignant neoplasms (except basal cell and squamous cell skin carcinoma) * treatment with glucose-lowering agent(s) other than stated in the inclusion criteria in a period of 12 weeks prior to randomisation
robotic versus laparoscopic roux en-y gastric bypass

Conditions: Roux-en-y Anastomosis Site; Obesity, Morbid; Bypass Complication; Anastomosis; Complications; Surgery-Complications

Summary: this study retrospectively identified 33 consecutive obese patients who underwent either laparoscopic or robotic gastric bypass procedures over a 2-year period.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) ≥35-39 kg/m2 with one obesity- associated co-morbidity * bmi≥40kg/m2, age ≥ 18 years. exclusion criteria: * re-do surgery procedures
system accuracy of the blood glucose monitor for personal use bg-709b

Conditions: Diabetes Mellitus

Summary: this study assesses the system accuracy a blood glucose monitoring systems pursuant to iso 15197

this study assesses the system accuracy the blood glucose monitoring systems for personal use bg-709b as outlined in din en iso 15197:2015.

Eligibility criteria:
inclusion criteria: * male or female patients with clinical indication for blood glucose testing * signed form of consent * minimum age of 18 years * subjects are legally competent and capable to understand character, meaning and consequences of the study exclusion criteria: * pregnancy or lactation * severe acute disease (at study physician's discretion) * acute or chronic diseases with inherent risk of aggravation by the procedure (at study physician's discretion) * current constitution that does not allow participating in the study (e.g. hematocrit out of the devices's specifications, medication known to influence blood glucose measurements; appendix a of iso 15197) * being unable to give informed consent * age younger than 18 years * legally incompetent
effectiveness of cervico-isthmic cerclage

Conditions: Cerclage, Cervical; Cervical Insufficiency

Summary: this study compares the rate of live births before and after cervico-isthmic cerclage in 3 hospitals in the last 10 years. the hypothesis is that cerclage significantly increases the rate of live births in women with cervical insufficiency.


Eligibility criteria:
inclusion criteria: * history of premature delivery or late miscarriage unrelated to maternal pathology, chorioamnionitis, fetal or placental pathology * patient aged over 18 at the time of the phone call * cerclage performed according to the benson technique verified on the operative report * cerclage performed in one of the 3 obstetric gynecology departments of the chu de lyon (lyon sud, croix rousse and hfme) between january 1, 2010 and april 1, 2019 exclusion criteria: * history of trachelectomy * surgical technique not specified or not deductible from the operating report * refusal to participate in the study * patient under legal protection

Keywords: cervico-isthmic cerclage cerclage cervico-isthmic cervical insufficiency miscarriage prematurity
sustain: behavior change and nutrition security for ckms

Conditions: Stage 2 Cardiovascular-Kidney-Metabolic Syndrome; Cardiovascular Disease Other

Summary: to determine the feasibility and engagement of participants in the sustain intervention compared to enhanced usual care over 24 weeks through mixed-methods measurement of participant enrollment, adherence, retention, and engagement (counseling, screenings, referrals, and uptake). methods: leveraging rigorous quantitative and qualitative evaluation, the study team will identify mechanisms driving intervention feasibility and engagement. hypothesis: sustain will be feasible with a high degree of engagement among medicaid-enrolled participants with stage 2 ckms in comparison to enhanced usual care.


Eligibility criteria:
inclusion criteria: * patients must be medicaid enrolled, and/or dual enrolled in medicaid * patients must be diagnosed with at least one of the following diseases: hypertension, type 2 diabetes mellitus, hyperlipidemia, chronic kidney disease and/or metabolic syndrome * patients must at least 18 years of age or older at the time of signing consent * patient must have access to internet-enabled device * patient has no objections to online grocery shopping, home food deliveries, or nutrition counseling * patient lives in setting able to receive instacart deliveries (e.g., non-institutionalized) * patient is willing to use a credit card for instacart back-up payments exclusion criteria: * have any condition that impacts digestion, metabolism, or food intake (e.g., surgical loss of esophagus, stomach, or colon, pancreatic dysfunction, bariatric surgery, brain surgery that alters cognition, etc.) * have active digestive illnesses (i.e., celiac disease, irritable bowel syndrome, chronic malabsorption) * any comorbidity such as psychiatric or general illness that may put the subject at risk as determined by investigator * any other factor which, in the investigator's opinion, is likely to compromise the subject's ability to participate in the study * recent (e.g., 6 months) participation in other behavioral nutrition trials * are currently pregnant or are planning to become pregnant during the study

Keywords: ckms cardiometabolic health cardiovascular-kidney-metabolic health cardiovascular-kidney-metabolic syndrome
radiofrequency catheter ablation for chronic atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the purpose of this study is to determine the long-term efficacy of radiofrequency catheter ablation in patients with chronic atrial fibrillation.


Eligibility criteria:
inclusion criteria: * chronic atrial fibrillation exclusion criteria: * left atrial diameter \>55 mm * left ventricular ejection fraction \<0.30 * contraindication to amiodarone therapy or anticoagulation with warfarin * presence of a mechanical prosthetic valve * history of a cerebrovascular accident * presence of left atrial thrombus on tee * prior attempt at catheter or surgical ablation for atrial fibrillation

Keywords: atrial fibrillation catheter ablation amiodarone cardioversion
comparison of at & pr training to improve functional ability after breast cancer surgery

Conditions: Breast Cancer

Summary: to determine the effect of aerobic training and progressive resistance training to improve upper limb functional ability after breast cancer surgery


Eligibility criteria:
inclusion criteria: * a) breast cancer female survivors eligible under 35-65 years complaining of cancer-related fatigue. b) adjunctive radiotherapy or underwent surgery (lumpectomy or mastectomy), willing to participate will be included in the study. c) shoulder pain d) decreased rom e) primary unilateral bc, alnd, no distant metastases, no previous alnd on the contra lateral side f) no previous history of arm lymph edema exclusion criteria: - a) survivors with other concurrent metastasis anywhere else in the body, diagnosed case of any cardiac or respiratory condition, contra-indicated for exercise training (severe dyspnea, chest pain, severe nausea, ataxia, dizziness etc.) b) any other neurological or recent musculoskeletal problems were excluded from the study. c) bilateral mastectomy d) adjunctive chemotherapy
a rtc to examine the effectiveness of 400 mg of oral zinc gluconate as adjunctive therapy for ano-genital warts

Conditions: Genital Warts; HPV

Summary: the purpose of this study is to examine the effect of 400 mg of oral zinc gluconate on genital warts. our hypothesis is that there will be a 10% difference in complete clearance of genital warts in the group randomized to oral plus standard of care compared to those randomized to placebo plus standard of care.

clients presenting to the bccdc sti clinic with genital warts will be randomized to either 400 mg zinc gluconate or placebo (200mg bid) for 8 weeks in addition to the standard of care. clinical assessment of warts and additional standard treatment will occur every 7-10 days for a maximum of 8 weeks. a telephone call will occur at week 20 to determine if any of the warts have cleared or re-appeared. the appearance of new warts will also be noted. the proportion of subjects who have complete clearance of genital warts at 8 weeks will be compared between groups.

Eligibility criteria:
inclusion criteria: 1. adults age 19 and over 2. clinical diagnosis of genital warts requiring treatment based on clinician evaluation 3. fluency in english 4. available within four days of the intended 8 week follow-up visit exclusion criteria: 1. individuals under the age of 19 2. pregnant women 3. known contraindication to zinc signs of copper/iron deficiency which include anemia and neutropenia which are characterized by tiredness, fatigue and light headedness. 4. diseases that alter zinc metabolism or absorption eg. type ii diabetes mellitus, crohn's disease, chronic leg ulcers 5. clients who are currently taking zinc for therapeutic purposes or have taken zinc in the last two months for therapeutic purposes 6. clients who have received standard of care treatment for their warts in the past month

Keywords: warts hpv zinc
self-management for persistent subacromial pain

Conditions: Shoulder Pain Chronic

Summary: physiotherapy-led exercises is the first line treatment for patients with subacromial pain. however, current evidence report that most treatment programmes only show a short-term benefit. there seem to be a potential for enhancing the effectiveness of exercise interventions by improving adherence to self-managed exercises, but there is lack of knowledge about adherence to exercise programmes in shoulder pain. before conducting a planned randomised controlled trial on the clinical effectiveness of an intervention focusing on adherence to a self-managed exercise strategy (the ad-shoulder intervention), it is necessary to run a feasibility study in order to establish whether such a resource-demanding trial is worthwhile. feasibility studies are designed to answer the key question "can it work?" the main objectives of the present study was to assess the feasibility in terms of recruitment capability, data collection procedures and acceptability of the ad-shoulder intervention in patients with subacromial pain receiving treatment in primary or secondary health care.


Eligibility criteria:
inclusion criteria: * pain located to the upper arm * had previously received conservative treatment due to subacromial pain * still seek primary or secondary care during the past 6 months exclusion criteria: * frozen shoulder diagnosis (\<50% external rotation compared to contralateral side) * patients who have received surgical treatment due to shoulder problems * pregnant patients * patients with insufficient norwegian language skills * serious psychiatric disorder

Keywords: shoulder pain persistent pain self-management exercise
optic nerve sheath diameter in prediction of fluid responsiveness

Conditions: Fluid Responsiveness; Optic Nerve Sheath Diameter; Shock

Summary: the aim of the study to examine optic nerve sheath diameter measurement for prediction of fluid responsiveness in hemodynamically unstable patients


Eligibility criteria:
inclusion criteria: * patients on mechanical ventilation * 18 years or older * patients developing hypotension (mean arterial blood pressure) \<65 mmhg exclusion criteria: * patients with spontaneously breathing activity. * patients with a history of intracranial disease e.g. (stroke, tbi, causes of increased intracranial pressure). * local cause in the eye as (glaucoma, single eye) * need for high peep. * known history of cardiac disease. * organ/s failure at admission
early life cohort in papua indonesia (elipi study)

Conditions: Malaria

Summary: malaria remains an important cause of illness in young infants. our clinical and epidemiological studies in papua (indonesia) have shown the magnitude of malaria morbidity in infants in the first 5 years of life, including recurrent episodes of malaria, anaemia, malnutrition and coinfection. together these contribute significantly morbidity in early life, and almost certainly to the very high infant mortality rates in this region. however the body of knowledge around infant malaria outside of africa, where both species p. vivax and p. falciparum are prevalent is considerable smaller. the impact of recurrent vivax malaria and severe anaemia on neurodevelopment and growth in young children is unknown in papua. this study therefore aims to provide longitudinal data on the incidence of symptomatic and asymptomatic malaria (p. falciparum and p. vivax) and the associated risk of anaemia. it also provides an opportunity to assess incidence risk of non-malaria febrile illnesses and bacterial co-infections and the long term outcomes in terms of neurodevelopment and growth in a vulnerable age group. the study is a continuation from two already established cohort studies: "stop mip", which enrolled pregnant women and followed them until delivery and a "baby-cohort", which enrolled babies from mothers included in the cohort and followed them through their first year of life. continuous follow up of those babies until they are 4 years old will increase our understanding of long term impact especially of vivax malaria. the cohort will be linked to a randomized controlled trial (rct) and will offer cohort patients to be enrolled into the rct when they are diagnosed with malaria (symptomatic), allowing to estimate treatment effectiveness.


Eligibility criteria:
inclusion criteria: * patient enrolled in the baby-cohort study exclusion criteria: * patients not enrolled in the baby-cohort study
episiotomy wound care, episiotomy wound healing and pain perception

Conditions: Episiotomy Wound; Wound Healing; Pain; Training, Toilet

Summary: the world health organization (who) and professional societies recommend restricted episiotomy instead of routine episiotomy. however, since the 1990s, there has been evidence of the risks of the procedure, and although routine use has no benefit, it is still widely used. in this study, investigators aimed to determine the effect of episiotomy on the wound healing process and pain perception by providing episiotomy wound healing and genital hygiene training with training material created to raise awareness about wound care after episiotomy and to eliminate factors that delay the healing of episiotomy wound.

this study aimed to determine the effect of episiotomy wound care and genital hygiene training on episiotomy wound healing and pain perception. methods: in this study, investigators used a randomized controlled trial approach. it was carried out in the postpartum service of the medical faculty hospital. 128 participants who underlap vaginal postpartum episiotomy were randomly assigned to the experimental and control group. the women who gave birth in the experimental group were given episiotomy wound care and genital hygiene training. the routine postpartum care was given to the participants who gave birth in the control group. the data were collected using the personal information form, the episiotomy area evaluation scale (reeda score), and the visual analog scale (vas). .

Eligibility criteria:
inclusion criteria: * 18 years of age and older * primiparous * givingbirth vaginally on due date (37-42 gestational weeks) * who have a healthy newborn, * who have a mediolateral episiotomy, * who do not have communication problems * who can understand and speak turkish were included in the research. exclusion criteria: * givingbirth by cesarean section * having third and fourth-degree perineal tears, * having a history of diseases that prevent wound healing, * using certain drugs (eg, glucocorticoids, anticoagulants, chemotherapy, immunosuppressant, and radiotherapy), * having chronic systemic diseases (heart, kidney and lung diseases, coagulation disorder, immunodeficiency, connective tissue disorders, and diabetes), * having history of genital warts, symptomatic vaginitis, * having history of perineal reconstructive surgery, any postpartum complication (hemorrhage, puerperal infection, mastitis, thromboembolic disease or postpartum psychiatric disorder)

Keywords: wound healing episiotomy genital hygiene postpartum care reeda scale