Kornimate/medical-research-clean huggingface dataset:
hierarchical diagnosis for adult diffuse glioma based on deep learning

Conditions: Astrocytoma; Glioblastoma Multiforme; Oligodendroglioma

Summary: this is a restrospective study to establish a deep learning model based on multi-parametric magnetic resonance imaging scans to predict grade, histopathologic type and genotype of adult diffuse glioma.

glioma is a common kind of tumor in central nervous system. the pre-operative prediction of grade, histopathologic type and genotype is important for treatment and management of adult diffuse glioma patients. right now, most of the diagnostic prediction models on glioma are based on 2016 who central nervous system tumor guideline. the goal of this study is to establish a new deep learning model to predict grade, histopathologic type and genotype of adult diffuse glioma. we will recruit 500 patients with pathologically confirmed diagnosis of glioblastoma, astrocytoma and oligodendroglioma who received neurologic surgery in our center. each subject underwent pre-operative multi-parametric magnetic resonance imaging scans including t1wi, t2wi, t1ce, flair and dwi. pathologic diagnosis of each patient are available in pathology department. a deep learning based hierarchical diagnosis

Eligibility criteria:
inclusion criteria: 1. patients undergoing surgery in nanjing drumtower hospital between 2010.01 and 2022.05 with post-surgery pathological diagnosis of who grade ii to iv adult diffuse glioma. 2. available pre-surgery t1wi, t2wi, t1ce, flari and dwi mr sequences 3. no pre-surgery anti-tumor therapy exclusion criteria: 1. poor image quality 2. failed image preprocessing 3. unavailable pathology data

Keywords: astrocytoma glioblastoma oligodendroglioma deep learning artificial intelligence
evaluation of 41 cases of pediatric granuloma annulare

Conditions: Granuloma Annulare

Summary: introduction: granuloma annulare is a non-infectious, granulomatous disease that can affect children and adults. although there are many studies examining adult patients, there are limited studies examining pediatric granuloma annulare cases. it is aimed to examine the demographic, clinical, and pathological features of pediatric granuloma annulare cases in this study. materials and methods: this study was performed retrospectively in a single-center, tertiary dermatology hospital. forty-one patients, under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. demographic characteristics, and clinical and histopathological features were evaluated.

granuloma annulare; is a non-infectious, granulomatous skin reaction with potential triggers that can affect the adult and pediatric age group. diabetes mellitus, hyperlipidemia, and malignancy have been described in association with adult granuloma annulare cases. while there are studies on the clinical, pathological features and associated diseases in patients with adult granuloma annulare, a limited number of studies have been conducted on pediatric granuloma annulare patients. therefore, clinical and histopathological evaluation of pediatric granuloma annulare cases was planned in our study. this study was performed retrospectively in a single-center tertiary dermatology hospital. patients under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. cases with uncertain diagnosis were not included in the study. cases with dermatological findings recorded in detail and/or diagnosed histopathologically were included in the study. demographic features, lesion localization, lesion characteristics (size, elementary lesion, color), involvement (localized/generalized), histopathological features, concomitant diseases, differential diagnoses in cases with histopathology, regression time and recommended treatments were recorded.

Eligibility criteria:
inclusion criteria: * being under 18 years old * having granuloma annulare * applying to the istanbul training and research hospital, dermatology outpatient clinic between 2008-2021 * consenting to participate in the study exclusion criteria: -being over 18 years old

Keywords: granuloma annulare pediatric dermatology pediatric granuloma annulare
modeling impaired judgement in cocaine abusers - 6

Conditions: Cocaine-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is for the modeling of impaired judgement in cocaine abusers.

the objective of this study is to investigate recognition memory and appreciation of changing contingencies in relation to a response judgement.

Eligibility criteria:
inclusion criteria: (3 groups)normal, healthy controls. recent cocaine experience. over 6 months since the last cocaine experience. exclusion criteria: psychosis or mood disorder. history of seizure, head trauma
comparing different surgical techniques for coverage of pressure ulcer

Conditions: Pressure Ulcer

Summary: the plastic, reconstructive and aesthetic surgery department of montpellier was born out of the wound and healing department, the first unit of this type to be created in europe. the investigators quickly became the national leader in the management of pressure ulcers, especially in people with spinal cord injuries. our expertise has evolved over time as well as our surgical techniques for covering ulcers, gradually over time the investigators have gone from " random " flaps to " propeller " flaps, more reliable in terms of vascularization and more logical in terms of force distribution and skin tension. the investigators found subjectively that the rate of complications was lower for the helical flaps. the investigators therefore seek to confirm this trend through a retrospective study on patients operated on in the department between january 1, 2015 and december 31, 2019.


Eligibility criteria:
inclusion criteria: * major patient * patient with trochanteric, ischiatic or sacral pressure ulcer * patient who undergone flap surgery for pressure ulcer between january 1st, 2015 and december 31st, 2019 exclusion criteria: * other loss of substance than pressure ulcer * combined covering with a random flap and a propeller flap * surgical revision of a flap without a new flap

Keywords: ulcer flap random propeller paraplegic surgery
young patient with aortic dissection or aneurysm: a prospective observational cohort study

Conditions: Aortic Aneurysm and Dissection

Summary: aortic dissection or aneurysm is unusual in young patients, and frequently associated with unusual presentations. however studies about this area is scarce. besides, the treatment option is not clare. the prognosis of this cohort is also unclear. the goal of this study was to better understand the characters, treatment option and prognosis of young patient with aortic dissection or aneurysm.

to understand the clinical characteristics, treatment options and prognosis of aortic dissection or aneurysm in young people，the study plan will include young people younger (≤50 years) with aortic dissection or aneurysm from 2020.6. then collect their clinical data and conduct follow-up studies, in order to understand younger aortic dissection or aneurysm patients.

Eligibility criteria:
inclusion criteria: * young patients with aortic dissection or aneurysm exclusion criteria: * aortic dissection or aneurysm due to traumatic
nuclear magnetic resonance for embryo ploidy selection

Conditions: Aneuploidy; Infertility

Summary: this study aims to validate the embryo culture medium analysis by nuclear magnetic resonance spectroscopy, as a faster and less-costly alternative to preimplantation genetic test for aneuploidy which could significantly enhance embryo selection and the success rate of assisted reproductive technologies.

assisted reproductive technologies (art) refers to treatments used to assist people in achieving a pregnancy. over the last years, art have been developed with efforts to deliver a healthy baby. however, the selection of the embryo that most likely results in pregnancy remains a critical step in art. currently, this selection is based on morphological assessment of the embryos, but up to 70% of those embryos display an abnormal number of chromosomes. preimplantation genetic test for aneuploidy (pgt-a) is used to assess the ploidy of embryos, although this is an invasive, expensive and time consuming technique. alternatively, in order to predict the ploidy of pre-implantation embryos (euploidy vs aneuploidy), we suggest to characterise the metabolic profile of the embryo culture medium by nuclear magnetic resonance (nmr), which is a non-invasive, low cost and fast technique. the aim of this study is to assess whether, using multivariable analysis to all the collected nmr data, it is possible to identify a differential metabolic pattern between aneuploid and euploid embryos which could improve embryo selection.

Eligibility criteria:
inclusion criteria: * age: ≥18 and \<49 years old. * body mass index ≥18.5 kg/m2 and \<30 kg/m2. * planned for in vitro fertilization followed by preimplantation genetic test for aneuploidy. * oocytes retrieval and fertilization by intracytoplasmic sperm injection * six follicles over 14 mm on the day of the triggering. gonadotropin-releasing hormone antagonist * signed and dated informed consent. exclusion criteria: * previous history of poor ovarian response (\<4 oocytes retrieved) with a maximal dose of ovarian stimulation (≥300 iu/day). * presence of a medical condition which is known to affect assisted reproductive technologies outcome (e.g. thyroid dysfunction). * active female smoking. * current use of anti-depressants, anti-psychotics, steroids, antiepileptics or chemotherapy. * those unable to comprehend the investigational nature of the proposed study.

Keywords: non-invasive embryo selection metabolic profile nuclear magnetic resonance
identification of gene biomarkers in aging skin

Conditions: Hyperpigmentation; Skin Aging

Summary: this study is a blinded, prospective, single-center, clinical study conducted in japanese female subjects between the ages of 20-75 years. this design uses skin biopsy samples from environmentally exposed areas and unexposed (control) areas within the same subjects to assess the gene expression profile from three different age groups.

the primary objective of the skin aging study is to investigate changes in gene expression patterns that occur during the aging process.

Eligibility criteria:
inclusion criteria: * individuals who are willing to read and sign an informed consent form prior to participating in the study. * individuals who have a temperature of less than or equal to 100 degrees f at the time of biopsy collection. * individuals who had not applied any sunless tanning product on the arms within the past year. * individuals with no prior history of alcoholism (or who consume fewer than 2 to 3 alcoholic beverages per day). * individuals who have not consumed any anti-aging nutritional supplements (multivitamins and multiminerals are acceptable) or aspirin, nsaids, or other pain medication in the last 48 hours before biopsy. exclusion criteria: * male gender * individuals who did not fit the 'inclusion criteria' above.

Keywords: skin aging dermogenomics genetic biomarker dermatology
long-term safety and performance of the argos-io intraocular pressure sensor system in subjects with primary open angle glaucoma (poag)

Conditions: Primary Open-angle Glaucoma

Summary: the purpose of this study is to evaluate the long-term safety and performance of the argos-io system in patients with primary open angle glaucoma (poag)

this study is a prospective open-label, multicenter study for clinical follow-up of the argos-01 and argos-02 patients. from the argos-01 to the argos-02 study, some modifications were made to the form of the argos-io implant in consequence of the outcomes of the argos-01 study. maximal 5 patients of the argos-01 study and maximal 21 patients of the argos-02 study will take part in this study. the sensor was always implanted in one eye only which will be the study eye.

Eligibility criteria:
inclusion criteria: * subjects of the argos-01 and argos-02 study with an implanted argos-io pressure sensor. exclusion criteria: * n/a

Keywords: poag primary open angle glaucoma cataract intraocular pressure intraocular pressure sensor system iop self-monitoring of intraocular pressure
effects of bisoprolol and atenolol on sympathetic nervous activity and central aortic pressure in patients with essential hypertension

Conditions: Untreated Essential Hypertension

Summary: β-blockers (bbs) with different pharmacological properties may have heterogeneous effects on sympathetic nervous activity (sna) and central aortic pressure (cap), which are independent cardiovascular factors for hypertension. hence, we analyzed the effects of bisoprolol and atenolol on sna and cap in hypertensive patients.


Eligibility criteria:
inclusion criteria: * 25\~65 years old * untreated essential hypertension * sbp 140-160mmhg \& dbp 90-100mmhg * sinus rhythm * resting heart rate \>70bpm * can give written informed consent exclusion criteria: * atrial fibrillation (af)/ sick sinus syndrome (sss)/ atrioventricular block 2-3 grade(avbⅱ-ⅲ) without pacemaker * bradyarrhythmia/ hypotensive * unstable angina pectoris (uap)/ami/ hf (nyha class iii - iv) * uncontrolled diabetes mellitus (dm) * bronchial asthma * gastro-intestinal ulcer or skin ulcer * liver dysfunction/ renal impairment * treated with ccb (calcium antagonists) ( except amlodipine) or other beta blocker. * glaucoma * known allergic/ intolerance to beta blocker * pregnant or lactating women * participation in another clinical study within the last 3 months * legal incapacity or limited legal capacity
trial of citicoline therapy in patients with mania or hypomania and cocaine abuse/dependence

Conditions: Mania; Hypomania; Cocaine Abuse; Cocaine Dependence

Summary: the purpose of this research is to determine if a citicoline supplement is associated with a reduction in cocaine use and craving in patients with bipolar disorder (a mental disorder marked by alternating periods of mania and depression) or schizoaffective disorder/bipolar type (a psychotic disturbance in which there is a mixture of schizophrenic and manic-depressive symptoms) and cocaine abuse/dependence. this research also wants to explore if citicoline supplements are associated with greater improvement in symptoms of mania and on memory and cognition (the mental faculty of perception, reasoning, and judgement) in these patients.

forty-four outpatients meeting the inclusion and exclusion criteria were enrolled after completing an institutional review board (irb)-approved informed consent process. baseline evaluation included a medical and psychiatric history, structured diagnostic interview using diagnostic and statistical manual (dsm)-iv criteria, mood assessment with the inventory of depressive symptomatology-self report (ids-sr), young mania rating scale (ymrs), and cognitive assessment with the rey auditory verbal learning test (ravlt). alternate but equivalent versions of the ravlt were used to minimize practice effects with repeated administration. cocaine use was assessed at each biweekly visit with urine drug screens. citicoline or placebo was given beginning at one tablet (500 mg)/day with an increase to two tablets (1000 mg/day) at week 2, three tablets (1500 mg/day) at week 4, and four tablets (2000 mg/day) at week 6. doses were decreased, if needed, due to side effects.

Eligibility criteria:
inclusion criteria: * men and women ages 18-70 years * history of mania or hypomania (bipolar i,ii, not otherwise specified (nos) or cyclothymic disorder or schizoaffective disorder/bipolar type) * early recovery for cocaine abuse/dependence (between 7 days and 12 weeks of enrollment). * any current mood state as indicated by structured diagnostic interview * no psychotropic medication changes within 7 days prior to enrollment. * english or spanish speaking exclusion criteria: * pregnant/nursing woman * current or past citicoline therapy * active suicidal or homicidal ideation with plan and intent * dementia, mental retardation or other severe cognitive impairment * severe or life threatening medical condition
whole body vibration in rehabilitation of spastic cerebral palsy

Conditions: Cerebral Palsy

Summary: spasticity is one of the most common features in children with cerebral palsy (cp) and is evident in the majority of cp types such as hemiplegia, diplegia, quadriplegia, etc. children with spastic upper motor neuron lesions often experience difficulties with muscle tone and movement, impacting their functional abilities and quality of life. conventional treatments such as physical therapy and medication have demonstrated positive effects in the management of spasticity. however, alternative interventions like whole body vibration (wbv) have gained attention due to their potential to modulate muscle tone and improve functional outcomes. wbv involves the transmission of mechanical vibrations to the whole body or specific body parts. these vibrations stimulate sensory receptors and elicit muscular responses, potentially leading to improved muscle tone regulation and reduced spasticity.

several studies have investigated the effects of wbv on spasticity management. these studies have reported various outcomes, providing valuable insights into the potential benefits of this intervention. previous studies showed an immediate reduction of spasticity of the calf muscle, increased the range of the popliteal angle, and improved step length, step width, foot angle, and walking speed. the current study seeks to address some of the limitations observed in previous research. it employs a randomized controlled trial design with a predetermined sample size, enhancing the statistical power and generalizability of the findings. the intervention group will receive supervised upper limb exercises using wbv, while the control group will receive conventional therapy. by comparing these two groups, the study aims to provide more robust evidence regarding the specific effects of wbv on muscle tone and spasticity. furthermore, the current study will utilize standardized assessment tools to measure muscle tone, spasticity, and functional outcomes pre-and post-intervention. this will allow for a comprehensive evaluation of the effects of wbv on spasticity management, encompassing both objective measures and functional improvements.

Eligibility criteria:
inclusion criteria: * age between 5 and 14 years, * who had a diagnosed with spastic cerebral palsy by a pediatrician, * 1-3 on ashworth scale (mas) for upper limb muscles * whose parents/guardians sign the informed consent, * who were willing to complete the study. exclusion criteria: * children with anatomical disorder or deformity in the upper limb, * children who received a botulinum toxin injection in the upper limb muscles during the last six months * surgery in the lower extremity during the previous year * severe associated neurological diseases as epilepsy * poor nutritional status. * those who do not agree to participate in the study.
effectiveness of an hiv-adapted imci training and supervision programme for community health workers

Conditions: Prevention of Mother-to-child Transmission of HIV; Antenatal Health Care Utilization; Postnatal Health Care Utilization; Infant Feeding Practices

Summary: this is a cluster randomized controlled trial (c-rct) to evaluate the effectiveness of a community-integrated management of childhood illness (c-imci) training for community caregivers (ccgs), adapted to include hiv-related interventions, on the delivery of maternal, newborn and child health interventions within households in rural communities in ugu district, kwazulu-natal (kzn) province, south africa. the intervention includes two components: (1) a 2-week hiv/c-imci training for ccgs and their associated facilitators and supervisors, and (2) continuous support and supervision following the continuous quality improvement (cqi) framework, a low-technology approach to management and supervision of health programs. the primary objectives of the proposed evaluation are to measure the effect of the intervention on key outcomes, including early uptake of antenatal care, facility based delivery, postnatal visits, coverage of exclusive breastfeeding, and uptake of hiv pcr testing in infants at 6 weeks. we will also examine the effects of the intervention on immunization uptake up to 12 months and knowledge and practices of ccgs and mothers pertaining to maternal, newborn and child health.


Eligibility criteria:
inclusion criteria: community caregivers * ccgs who work in ugu district * age 18 years or older * with grade 9 education or greater mothers * mothers age 18 years and older who delivered a live-born infant within the prior 12 months * reside in households served by participating ccgs. exclusion criteria: * none

Keywords: community health workers hiv pmtct antenatal postnatal breastfeeding south africa
effect of low-level laser therapy on salivary toll like receptor- 4 concentration of periodontitis patients: a relation to periodontal inflammaging

Conditions: Periodontal Disease

Summary: effect of low-level laser therapy on salivary toll like receptor- 4 concentration of periodontitis patients: a relation to periodontal inflammaging

effect of low-level laser therapy on salivary toll like receptor- 4 concentration of periodontitis patients: a relation to periodontal inflammaging

Eligibility criteria:
inclusion criteria: 1. male or female 2. aged below 40 or above 60. 3. have at least 16 natural teeth excluding wisdom. 4. provide informed consent and willingness to cooperate with study protocol. 5. periodontitis stage ii patients (23): * cal from 3-4 mm. * radiographic bone loss (15% to 33%). * no tooth loss due to periodontitis. * maximum probing depth ≤ 5 mm, mostly horizontal bone loss exclusion criteria: * 1- patients with any smoking habits 2- history of antibiotics in the previous three months. 3- pregnant or lactating female. 4- treatment with any systemic drug. 5- history of systemic disease. 6- patients who received periodontal treatment in the last 6 months

Keywords: inflamaging