Kornimate/medical-research-clean huggingface dataset:
clinical trial on acupuncture adjuvant treatment in the pain after the surgery of gastrointestinal carcinoma

Conditions: Gastrointestinal Carcinoma; Pain

Summary: clinical trial on acupuncture adjuvant treatment in the pain after the surgery of gastrointestinal carcinoma. gastrointestinal cancer patients are diagnosed by pathology or cell biology. patients are randomized into 2 groups: the control group receive normal treatment only, the experimental group receive acupuncture therapy besides normal treatment. clinical evaluation is based on the observation of the pain degree and life quality improvement. blood biochemistry tests mainly include prostaglandin e2(pge2),5-hydroxytryptamine(5-ht), histamine(his), malondialdehyde (mda), superoxide dismutase (sod), glutathione peroxidase (gsh-px), adrenaline, nor-adrenaline, tumor necrosis factor (tnf)-α, cell flow cytometry on th1, th2, th17, treg cytokines as well as serum cortisol, estradiol (female), progesterone (female), testosterone (male) etc.


Eligibility criteria:
inclusion criteria: 1. general anesthesia,gastric and colorectal cancer surgery under laparoscopic; 2. pathology diagnosed; 3. brain, heart, lung, liver, kidney are at good condition before surgery; 4. no mental disorder, no conscious obstacle, no limbs disability. exclusion criteria: 1. severely complication after surgery; 2. contraindication of the acupuncture; 3. patients with mental disease; 4. patients taking part in other clinical trials, being treated with other biotherapy or immunotherapy and researchers consider not suitable for clinical subjects for other reasons will be excluded.

Keywords: acupuncture therapy pain degree after surgery
effect of inspiratory muscle training on posture in chronic obstructive pulmonary disease patients

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is a respiratory disease that results in progressive airflow limitation and respiratory distress. physiopathological features of copd suggest that people who suffer from this disease have many risk factors for falls that have been identified in older individuals. risk of falls is multi-factorial and impaired balance has been shown to contribute. the investigators aimed to demonstrate that, imt performed during a prp may improve postural control in copd patients.

chronic obstructive pulmonary disease copd is a preventable and treatable disease. according to the who, copd would be the third leading cause of death by 2030. this disease is characterized by airflow limitation that is not fully reversible. the airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases. however, emerging data showed that copd patients demonstrate important deficits in balance and control which associated to a high risk of fall. individuals with copd, especially those with inspiratory muscle weakness, increased their reliance on ankle muscle proprioceptive signals and decreased their reliance on back muscle proprioceptive signals during balance control, resulting in a decreased postural stability compared to healthy controls. these proprioceptive changes may be due to an impaired postural contribution of the inspiratory muscles to trunk stability. inspiratory muscle training (imt) has been shown to be an effective modality for copd patients for improving the maximal inspiratory muscle strength, the dyspnea and health-related quality of life. however, the effect of inspiratory muscle training on postural control is not studying. the purpose of this study is to evaluate the effect of the inspiratory muscles training on posture in copd patients.

Eligibility criteria:
inclusion criteria: * were copd diagnosed by pulmonary function testing * clinically stable * abscence of other obstructive diseases * signed written consert exclusion criteria: * were previous pneumonectomy or lobectomy in the past 6 months * spontaneous risk of pneumothorax or rib fracture * incapacity to follow a standard rehabilitation programme (locomotor deficits, acute cardiac failure and acute exacerbation of copd at the beginning of the programme) * lower limb injury * neurological injury or disease * the absence of written informed consent

Keywords: copd imt cop ml cop ap posture
new echocardiographic parameters for prediction of response to cardiac resynchronization therapy

Conditions: Congestive Heart Failure

Summary: echocardiography parameters for cardiac dyssynchrony had no predictive value in current multicentric prospective studies concerning cardiac resynchronization therapy. comprehensive echocardiography and new parameters as 2d and 3d strain, as well as 3d echo have been analyzed, but their definite value has not been proven yet.

in patients with severe heart failure, delays in the conduction system can result in asynchronous contraction impairing cardiac function. by implantation of pacemaker systems with three leads located in atrium, right ventricle and coronary sinus, tracing back this deranged contraction closer to the physiological excitation propagation is aimed (cardial resynchronization therapy \[crt\]). despite patient selection according to the guidelines nearly one-third of the patients do not profit, neither clinically nor echocardiographically, from an implanted crt-device. in addition, recent studies have shown that no reliable prediction may be achieved with the known echocardiographic parameters of dyssynchrony, regarding the response to such therapy. the aim of this study is therefore to assess new echocardiographic parameters, which may allow to better predict crt response.

Eligibility criteria:
inclusion criteria: * congestive heart failure, dilated cardiomyopathy, indication for implantation of a crt-device according to the european society of cardiology (esc) exclusion criteria: * persons who are incapable of giving informed consent * acute heart attack * arrhythmia during the examination (such as atrial fibrillation and frequent ves) * state after stemi with an extended scar * inotropic drug therapy * pre-existing permanent pacemaker stimulation
nasal hfov versus nasal cpap to reduce post-extubation pco2

Conditions: Respiratory Distress Syndrome, Newborn; Respiratory Tract Diseases

Summary: to investigate whether nasal high frequency oscillation ventilation (nhfov) immediately after extubation reduces the arterial partial pressure of carbon dioxide (paco2) at 72 hours after extubation in comparison with nasal continuous positive airway pressure (ncpap) in very low birth weight infants (vlbws).

randomized controlled clinical trial comparing nhfov vs ncpap immediately after extubation of vlbw infants. intervention and treatment protocol as described for the two study arms. definition of treatment failure (infant meets at least one criterion): * sustained pco2 \>80 mmhg and ph \<7.20 confirmed by arterial or capillary blood gas analysis in spite of optimized non-invasive respiratory support with maximum settings as defined above. * fraction of inspired oxygen (fio2) \>0.6 to maintain peripheral oxygen saturation as measured by pulse oximetry (spo2) at 90-94% in spite of optimized non-invasive respiratory support with maximum settings as defined above. * reintubation (study patients may be intubated at any time, due to clinical considerations, with or without reaching another criterion of "treatment failure"). sample size: assuming a variability of the paco2 as previously reported for difficult-to-wean preterm infants in our unit (czernik c, j matern fetal neonatal med 2012) and a treatment failure rate of 22% within 72 hours after extubation, we calculated a sample size of 34 patients in each study arm to detect a difference in the paco2 of 7 mmhg, using a two-sided significance of 0.05 and a power of 0.8. randomization: sequence generation by an independent statistician and a study nurse. block randomization using at least two different block sizes. allocation concealment using sequentially numbered opaque sealed envelopes. data monitoring: by an independent statistician.

Eligibility criteria:
inclusion criteria: * gestational age \<32+0 weeks * birth weight \<1500 g * received mechanical ventilation via an endotracheal tube for ≥120 h * caffeine treatment according to unit guidelines * paco2 \ 7.2 * fio2 25-40% to maintain spo2 at 90-94%. * time-cycled, pressure-controlled ventilation: pip ≤22 cm h2o, peep ≤6 cm h2o; volume guarantee ventilation: working ppeak ≤22 cm h2o, peep ≤6 cm h2o; high frequency oscillation ventilation: pmean ≤12 cm h2o, amplitude ≤30 cm h2o * decision of the attending clinician to extubate exclusion criteria: * major congenital malformation requiring surgery * duct-dependent congenital heart disease * neuromuscular disease * participation in another randomized controlled trial * death before reaching the eligibility criteria * hydrocortisone treatment at the time of enrolment * chronological age \>28 days

Keywords: high frequency oscillation ventilation nasal continuous positive airway pressure airway extubation prematurity
the effects of neurophysiological facilitation techniques after coronary artery bypass graft surgery

Conditions: Cardiac Disease

Summary: the aim of the study is to investigate the effects of neurophysiological facilitation techniques, applied in addition to phase i cardiac rehabilitation in the early postoperative period after coronary artery bypass graft (cabg) surgery, on left ventricular function, respiratory functions, and functional capacity.

in this prospective randomized controlled study, participants will be randomly divided into two groups: the control group, which will receive phase i cardiac rehabilitation, and the treatment group, which will receive phase i cardiac rehabilitation along with the application of neurophysiological facilitation techniques. the participants' left ventricular function, respiratory functions, and functional capacity will be assessed before and after the interventions.

Eligibility criteria:
inclusion criteria: * first-time undergoing open-heart surgery * aged between 50 and 85 years * full cooperation exclusion criteria: * presence of facial, sternum, or rib fractures * chronic renal failure * development of cerebrovascular events * cognitive function impairment * development of deep vein thrombosis in the postoperative period * presence of neuromuscular disease * presence of orthopedic disabilities * intubation duration longer than 24 hours * staying in intensive care for more than 48 hours

Keywords: coronary artery bypass respiratory function test ventricular ejection fraction
managing pain in patients with plantar fasciitis - a blinded randomized controlled trial

Conditions: Plantar Fasciitis

Summary: plantar fasciitis (pf), a leading cause of persistent heel pain, results in almost a million physician visits annually. conservative treatment is often the first line of management with insoles being frequently prescribed. while multiple studies have compared insoles based on the degree of customization to foot contour, the literature is lacking in data comparing insoles based on their material. in this randomized clinical trial, we compared the early effects of polyethylene (pe), polyurethane (pu), and carbon fiber insoles in the treatment of pf, using a set of patient-reported outcomes.

carbon fiber insoles (vktry, milford, ct, usa) were initially designed to increase ground forces leading to a harder push off for faster running or higher jumping. to enable energy return, the insoles require extreme rigidity and therefore are composed of a full-length carbon-fiber base. the highly rigid construct of the carbon fiber can potentially benefit patients with plantar fasciitis by using these insoles in their own shoes, which could lead to more effective pain management, increased compliance, and improved patient outcomes. while this insole is currently being widely used by athletes, the application of this insole for pf patients has not been explored. therefore, the aim of this study is to understand how patients respond to the these insoles compared to current standard orthotics (superfeet green, superfeet worldwide llc. wa, usa and aetrex l20, aetrex inc, nj, usa) in a blinded randomized controlled trial.

Eligibility criteria:
inclusion criteria: * adult patients (over 18 years old) with plantar fasciitis * adults who are competent and able to consent on their own behalf * patients who are seen at mgh boston, mgh waltham and newton wellesley hospital exclusion criteria: * patients who received an injection in the last 6 months in their plantar fascia * patients who will need to be treated surgically * patients who are non-english speaking
osteopathic protocol for insomnia in college students

Conditions: Insomnia

Summary: in this randomized controlled experimental trial, it is aimed to determine the effectiveness of an osteopathic protocol treatment for insomnia in college students. in this study, will be used the compression of 4th ventricle (cv4) and the diaphragmatic breathing technique.

insomnia is a sleep disorder defined by persistent difficulty in initiating, maintaining or consolidating sleep. it can also be defined by early morning awakenings or having a dissatisfied sleep quality, even if you have plenty of time and a suitable environment to a restful sleep. this difficulty sleeping must be experienced at least 3 nights per week, for 3 consecutive months. this can often lead to symptoms such as fatigue, irritability and difficulty concentrating during the day. both compression of 4th ventricle and diaphragmatic techniques have been proven to help lower the tone of the sympathetic nervous system, restoring a normal respiratory mechanism. it is anticipated that the combination of 4th ventricle technique and diaphragmatic breathing may result in a significant reduction in insomnia symptoms, providing study participants with a notable improvement in the quality of sleep and, therefore, in their general well-being.

Eligibility criteria:
inclusion criteria: * being a college student * insomnia presence * willingness to complete a full study period * understanding and acceptance of the study procedures * willingness to refrain from other intervention during the study period * availability to keep a diary (sleep and mood throughout the day) exclusion criteria: * having suffered a stroke or aneurysm * hypertension * fractured the base of the skull * pregnancy * active insomnia treatment * participation in other simultaneous studies * regular use of sleep medication * have participated in complementary therapies for insomnia recently

Keywords: cv4 diaphragmatic breathing insomnia osteopathy college students
the feasibility of florbetapir quantitation in europe

Conditions: Alzheimer's Disease

Summary: this study will evaluate whether the addition of quantitation as an adjunct to visual interpretations significantly improves the accuracy of amyvid scan interpretation.


Eligibility criteria:
inclusion criteria: * readers have undergone amyvid reader training * readers have not more than minimal experience with quantitation of amyloid pet scans exclusion criteria: * readers have previously been trained to quantitate amyloid pet scans
determining the efficacy of essential oil aromatherapy in children undergoing port access

Conditions: Anxiety and Fear; Pain

Summary: the purpose of this study is to determine if the use of aromatherapy impacts patient anxiety and pain scores surrounding port access in pediatric oncology patients between the ages of 4 years and 18 years.

specific aims include the following: aim 1: to compare pre and post port access anxiety scores for both control and intervention groups. aim 2: to assess pre and post port pain scores surrounding port access for both control and intervention groups. aim 3: to compare pain and anxiety scores between age groups. the overall goal of this pilot study is to identify if aromatherapy, using non-topical, still quicktab medipack blended scent aromatherapy, manufactured by soothing scents, is effective as a valid non-pharmacologic supplementation in reducing anxiety and pain scores during port access in pediatric oncology patients.

Eligibility criteria:
inclusion criteria: 1. children between 4 years and 18 years 2. scheduled for port access with or without lab draw 3. oncology, neuro-oncology, and stem cell transplant patients exclusion criteria: 1. has asthma, reactive airway disease, or allergies to any of the ingredients we are using in the aromatherapy study (lavender, bergamot, sweet orange, and ylang ylang) 2. currently uses aromatherapy for port accesses or other painful procedures (does not apply to patients using aromatherapy, such as peppermint oil, for nausea) 3. has a cognitive impairment that prevents them from being able to provide anxiety or pain scores 4. does not wish to participate in the study

Keywords: aromatherapy port-a-cath pediatric
prospective study on the feasibility of plasma flt3-ligand assay to achieve a first estimate of its prognostic value on the outcome of patients treated intensively for acute leukemia

Conditions: Acute Leukemia

Summary: despite advances in their classification and treatment, acute leukemia remain incurable disease for the majority of patients. it is necessary to identify new prognostic markers of survival and new therapeutic targets to improve prognosis. some studies have shown that fms-like tyrosine kinase 3-ligand (flt3-l) could be interesting from this. a more recent study from our group testing a novel therapy in acute lymphoblastic leukemia, showed an increase of this marker in the blood of patients responding to treatment. the aim of our prospective, non-interventional study is to measure the plasma levels of flt3-l at different times of the management of patients with acute lymphoblastic leukemia but also myeloid. for this, analyzes of the samples collected in the usual care will be conducted to study the relationship between the plasma concentration of flt3-l and outcomes. if there is any link, the flt3-l could serve as a predictor of treatment response.


Eligibility criteria:
inclusion criteria: * acute myelogenous leukemia diagnosis or lymphoblastic * patient intensively treated * patients who agreed to participate in the study and having signed the consent biocollection non-inclusion criteria: * patient aged under 18
the effects of traditional massage on spasticity and activity of children(2 to 10 years) with cerebral palsy

Conditions: Cerebral Palsy, Spastic, Diplegic

Summary: the study has been conducted to see the effects of traditional massage on spasticity and activity of children with cerebral palsy (cp). it is a randomized controlled trial having two groups, control and intervention. both groups received routine physical therapy treatment comprising stretching of tight muscles, strengthening of weak muscles, positioning and handling. intervention group also received traditional massage in addition to routine physical therapy. caregivers were trained to perform routine physical therapy treatment and traditional massage at home. data was collected using a structured questionnaire, modified ashworth scale (mas), gross motor function classification system (gmfcs), gross motor function measure (gmfm) and cpchild caregiver priorities \& child health index of life with disabilities at baseline, after 06 weeks and 12 weeks of intervention.

physical therapy is an important component of rehabilitation regimen which is commonly used in the management of children with cp. massage is also used as a complimentary alternative medicine (cam). it has many types being practiced across the globe. traditional massage is a type of massage being practiced in a specific society and has its own way of execution. it does not need professional education, training and certification so do not have any financial burden on the caregivers. as pakistan is a poor country with low socio-economic status, so such measures of management which involve less financial burden on caregivers need to be investigated. in this rct, traditional massage was performed on the participants in the supine lying position. each upper and lower limb was massaged for five minutes with gentle rubbing in proximal to distal direction. five minutes massage was also provided at front and back of trunk area each in center to periphery direction. this type of traditional massage is practiced in pakistan population which is somewhat different to swedish massage. in few previous studies effect of swedish massage on spastic cp has been investigated with conflicting level of evidence. however no study has been conducted in pakistan to see the effects of traditional massage on children with cerebral palsy.

Eligibility criteria:
inclusion criteria: * child should have diagnosis of spastic cerebral palsy (hemiplegic and diplegic types only). exclusion criteria: * children having moderate to severe contractures. * children having moderate to severe mental retardation and with multiple disabilities. * children with attention deficit hyperactive disorder (adhd), uncontrolled seizures and behavioral disorders

Keywords: cerebral palsy, traditional massage, spasticity, children
surgical sympathetic blockade in heart failure

Conditions: Systolic Heart Failure; Beta-blockers Intolerance; Beta-blockers Resistance

Summary: the investigators sought to evaluate the feasibility and safety of surgical sympathetic blockade in systolic heart failure patients and secondary to assess its cardiovascular consequences.


Eligibility criteria:
inclusion criteria: * chronic heart failure (at least 1 month of symptoms onset) * nyha functional class ii or iii * lv ejection fraction 40% or lower * resting heart rate higher than 65 bpm * either maximum beta-blocker therapy according to guidelines or no beta-blocker use for intolerance. exclusion criteria: * nyha functional class i or iv * cardiogenic shock * resting heart rate ≤ 65 bpm * systolic blood pressure \< 90 mmhg * sustained ventricular tachycardia * eligibility to other surgical procedures * procedure-limiting comorbidity * presence of icd or pacemaker * valvar, chagasic or congenital cardiomyopathy * age \> 70 years * patient refusal * contra-indication to videothoracoscopy * decompensated thyroid disease * atrial fibrillation or flutter * active infection

Keywords: heart failure sympathetic nervous system sympathectomy adrenergic beta-antagonists ventricular dysfunction, left
effect of amlodipine monotherapy or combined with terazosin on lower urinary tract symptoms and hypertension

Conditions: Lower Urinary Tract Symptoms; Hypertension

Summary: the aim of this study was to investigate the efficacy and safety of low dose amlodipine alone, or combined with low dose terazosin in male patients with both lower urinary tract symptoms and hypertension.


Eligibility criteria:
inclusion criteria: 1. men 50 years or older 2. with luts \[defined as international prostate symptom score (ipss) \>= 10\]. 3. stage 1 or 2 essential hypertension (sbp \>= 140 mm hg and \ = 90 mm hg and \< 110 mm hg) exclusion criteria: 1. a history of postural hypotension 2. secondary hypertension 3. prostate cancer 4. prostate surgery or other intervention 5. use of any agents to influence the luts symptoms in the last 4 weeks 6. other severe diseases

Keywords: amlodipine terazosin lower urinary tract symptoms (luts) essential hypertension international prostate symptom score (ipss) quality of life (qol)