Kornimate/medical-research-clean huggingface dataset:
effect of elderberry juice on cognition and inflammation in patients with mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: elderberries (sambuci fructus) have been shown in a number of studies to have significant anti-inflammatory and antioxidant effects. multiple human and animal studies have supported the anti-inflammatory and antioxidant effects of elderberry preparations and it has been used in natural medicine for hundreds of years. studies examining factors that may decrease the risk of alzheimer's disease have revealed that drinking juices with similar properties to elderberries is one of the most reliable way to decrease risk. as such the investigators wish to determine the effects of elderberry juice on cognitive decline in a group of subjects at high risk for alzheimer's disease, those with mild cognitive impairment. elderberry juice is a commercially available nutritional supplement and easily available to this population.


Eligibility criteria:
inclusion criteria: * cdr score of 0.5 * mmse of at least 24 * age 50 or older exclusion criteria: * known history of sensitivity to elderberry products. * diabetes. * bleeding disorder. * current pregnancy. * known allergy to honeysuckle. * currently making changes to other drugs that might affect cognitive performance (subjects showing the greatest cognitive decline and other signs of alzheimer's disease may be prescribed cholinesterase inhibitors as this is a standard of care for alzheimer's disease but not mci). * presence of any condition the health professional believes will impair ability to complete study procedures (ex. terminal illness, comorbid major psychiatric disorders such as schizophrenia, or drug abuse). * potentially confounding neurodegenerative diseases (e.g. ms).

Keywords: elderberry juice alzheimer's inflammation
improving hypertension care for inner city minorities

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension

Summary: to improve long-term blood pressure bp) control in a predominantly african-american, low ses community of a large city.

background: the study was in response to a demonstration and education initiative, "improving hypertensive care for inner city minorities", which was reviewed and approved by the clinical applications and prevention advisory committee in april 1992 and by the national heart, lung, and blood advisory council in may 1992. the request for applications was released in october 1992. design narrative: components of the program included a community education campaign, an educational intervention for private physicians, and major modifications in the process of care for hypertensives in a health care system that was the largest single provider to the target area. the intervention area was compared to a similar community in another part of the city which was served by different private and public providers. pre- and post-intervention random samples of persons ages 18-74 were selected from each geographical area to assess the effectiveness of the program in reducing the prevalence of uncontrolled hypertension. the community intervention focused on improving awareness and need to maintain treatment. the private physician intervention focused on strategies for promoting long-term patient adherence. the public hospital clinic/systems components were: 1) educating providers, 2) instituting an evening clinic for the working poor, 3) providing tailored patient education programs which were culturally sensitive and did not require class attendance, and 4) implementing a program in the public hospital emergency center to identify and refer patients with undetected hypertension or hypertension not under regular care. efforts, including reminders and follow-up by community health center social workers, were used to keep patients active in treatment programs. the community intervention was directed by the co-investigator from texas southern university (tsu), an historically black university located in the intervention area. he had extensive experience in community outreach. the intervention toward private physicians was directed by investigators from baylor college of medicine who had established clinical credibility in the physician community. the investigators from baylor also had direct supervision over the physicians who provided care in the harris county hospital district (hchd) public health care system. the hchd was deeply committed to the project and had a high level of representation in all the planning phases.

Eligibility criteria:
no eligibility criteria
biofeedback breathing training influence cardiac autonomic nervous system in children with cerebral-palsy.

Conditions: Cerebral Palsy; Autonomic Nerveus System

Summary: the effect of breathing biofeedback training to influence the function of the cardiac autonomic nervous system at rest and in activity in children with cerebral palsy. cerebral palsy children suffer from a non-progressive damage of the brain. it is the most common injury that causes physical handicapped in childhood. there are a few researches that investigated the autonomic function in cerebral palsy children. those researches found hyperactivity of the sympathetic autonomic system, including high resting heart rate compare to their typically developed pears. the recommended treatment for cerebral palsy is activity, muscle strengthening and mobility. the impairment in the autonomic system influences the everyday function and has correlation with secondary morbidity. as far as we know there are no researches who investigated the following issues. in this study we would like to: 1. describe the autonomic cardiac function, breathing function, motor function and the correlation between them in children with cerebral palsy. 2. compare the autonomic cardiac function at rest in aerobic test and in diaphragmatic breathing. 3. test the influence of breathing training on heart rate variability parameters at rest, in aerobic test right after the breathing training program and one month after, in children with cerebral palsy

participants: 60 children with cerebral palsy age 6-11 who can walk and understand simple instructions. main outcome measures: heart rate variability using polar watch and transmitter rs810cx. secondary outcome measures: 1. lung functioning using sensormedics vmax 29 spirometry:forced vital capacity, forced expiratory volume in one,tidal volume. 2. biofeedback 3. sub maximal aerobic test on treadmill-modified naughton protocol with polar watch and transmitter. 4. gross motor function classification system 5. gross motor function measure 6. functional mobility scale 7. children assessment of participation and enjoyment 8. autonomic function questionnaire

Eligibility criteria:
inclusion criteria: * children with cerebral palsy * age 6-11 years * able to walk * both gender exclusion criteria: * heart or lung known disease * can not follow simple commends

Keywords: cerebral palsy autonomic nerveus system heart rate variability
physical therapy to prevent osteopenia in preterm infants

Conditions: Metabolic Bone Disease

Summary: to determine whether reflex locomotion therapy is effective for the prevention of osteopenia in preterm infants and compare its effectiveness over other physiotherapeutic methods like passive joint mobilizations and massage

premature infants have smaller and low bone mineralization compared with term infants bones, since 80% of calcium uptake occurs at the end of pregnancy. passive physiotherapy has been effective in the treatment of osteopenia. active mobilizations implemented by the baby itself, may be more effective than passive, as they cause muscle contraction from the central nervous system (cns). reflex locomotion therapy (rlt), stimulates cns causing muscle contraction so it may be effective in the treatment of osteopenia in premature. objectives: to determine whether rlt is effective for the prevention of osteopenia in preterm infants and compare its effectiveness over other physiotherapeutic methods. methodology: our study is a multicentre randomized clinical trial, with 90 children less than 34 weeks of gestational age, divided into three treatment groups, one will receive rlt, another will be treated with passive joint mobilizations with articular pressure; and last one will be done massage techniques. the treatment will last for one month, for the three groups. we intend to measure changes in mineralization, bone formation, and bone resorption, and anthropometry.

Eligibility criteria:
inclusion criteria: * preterm infants * 26 to 34 weeks of gestational age * admitted in neonates * hemodynamically stable * complete enteral nutrition * parents or guardians signed an informed consent authorizing the participation of the baby in this study. exclusion criteria: * neurological disorders * mechanical ventilation * bronchopulmonary dysplasia * congenital malformations * metabolic diseases * genetic diseases * intraventricular hemorrhage iii-iv, * diuretic medication or corticosteroids * bone fractures at the time of inclusion.

Keywords: premature infant physical therapy modalities
feedback loop between intracranial atherosclerosis and cerebral small vessel disease

Conditions: ICAS - Intracranial Atherosclerosis; Cerebral Small Vessel Diseases

Summary: the present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.

cerebrovascular disease is the most common cause of death worldwide. there is a close link in structure and function between the intracranial large arteries and cerebral small vessels. moreover, growing evidences have demonstrated that large artery atherosclerosis often coexists with small vessel disease, which may deteriorate the clinical outcomes of stroke and dementia. the mutual feedback mechanism between them is not fully understood. the present study focuses on the mechanism of mutual feedback between large artery atherosclerosis and cerebral small vessel disease by using magnetic resonance imaging. the study may provide biomarkers for the early prevention and treatment of cerebrovascular disease.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * at least one intracranial artery ≥ 50% atherosclerotic stenosis * modified rankin scale \< 2 * mini-mental state examination \> 24 exclusion criteria: * concurrent ipsilateral extracranial artery ≥ 50% stenosis * pregnant women * contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)

Keywords: intracranial atherosclerosis cerebral small vessel disease feedback mechanism multimodal mri
suicidality and suicide attempt among hiv patients on efavirenz-containing versus efavirenz-free antiretroviral regimens

Conditions: HIV Infection

Summary: the purpose of this study was to compare the frequency of suicidality and suicide attempt among hiv patients starting treatment with efavirenz and with patients starting treatment with other hiv medications.


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * at least 6 months of enrollment before first prescription * antiretroviral naive exclusion criteria: * no diagnosis of hiv on patient record * age \< 12 years
the effect of hypercapnia on physiological parameters during short-term breathing

Conditions: Hypoxia; Hypercapnia; Cardiac Output, High

Summary: the aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.

hypercapnia causes changes in physiological parameters at various levels throughout the body. the study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. it is an intervention prospective study that will be conducted at the faculty of biomedical engineering on healthy volunteers. all the volunteers undergo three different phases in random order. the individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.

Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * pregnancy * severe cardiovascular conditions * severe asthma or other severe respiratory conditions * injury to the upper limbs or hands that could affect the peripheral perfusion * diabetes * hypotension or hypertension

Keywords: cardiac output perfusion index pulse oximetry
effect of mental stress on platelet function

Conditions: Mental Stress

Summary: the aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages

psychological stress is an important cardiovascular risk factor. activation of platelets plays an important role in atherosclerosis development and it could be one of the mechanisms linking psychological stress and cardiovascular diseases. we plan to include 32 healthy subjects. (16 in every group). one group with subjects at age 20 - 49 and the other group with subjects at age 50 - 70 years. the aim of the study will be to assess the acute and chronic effect of a standard short mental stress (2-minute bondet test) on platelet function and of the level of endothelin-1, catecholamines and cortisol. we plan to evaluate if age may play a role in the effect of psychological stress on platelet function.

Eligibility criteria:
inclusion criteria: * healthy subjects between 20 - 70 years of age * written informed consent * no evidence of diseases exclusion criteria: * pregnancy * oral contraceptives * smoking * use of aspirin or nsaids within the last week * use of benzodiazepines within the last week * alcohol or drug abuse * participation in another study within the last month

Keywords: mental stress platelet adhesion platelet function catecholamines
a phase ii study of oxaliplatin in association with 5fu and folinic acid in the treatment of subjects with non-surgical or advanced metastatic gastric cancer

Conditions: Stomach Neoplasms

Summary: this phase ii trial will evaluate, in first line advanced or metastatic gastric cancer, the efficacy and tolerance of another oxaliplatin, 5fu bolus combination already tested in advanced colorectal cancer


Eligibility criteria:
inclusion criteria: * histologically proven gastric or gastroesophagic junction adenocarcinoma * measurable disease at least in a unidimensional manner. if a unique metastasis constitutes the only disease symptom, histological confirmation will be required * metastatic or locally non-surgical primary gastric cancer * recurrent gastric cancer after local and/or systemic treatment with a post-surgical period of at least 4 weeks, a post-adjuvant chemotherapy period or a neo-adjuvant chemo-radiotherapy of at least 6 months * serum bilirubin\< 2 mg/dl * serum creatinine \< or =to 2 times normal superior limit * absolute neutrophil count \> or =to 2000/dl * platelet count \> or =to 100000/dl * hemoglobin \> or =to 10 g/dl * ast/alt \< or =to 2.5 times normal superior institutional limit * alkaline phosphatase \< or =to 5 times the normal superior institutional limit * age \> 18 years * performance status ecog 0-2 * written informed consent signed and dated exclusion criteria: * symptomatic sensory peripheral neuropathy * uncontrolled concomitant disease.(e.g. severe diabetes mellitus, arterial hypertension) * any other malignancy diagnosed within 5 years previous to the gastric cancer, with the exception of " in situ " cervix carcinoma or non-melanoma skin cancer * concomitant anti-tumoral treatment * cerebral metastases * unstable heart disease, even though under treatment * myocardial infarction within the last 6 months * pregnancy or nursing (or women in reproductive life without adequate contraception) * significant neurological or psychiatric disorders
interrater reliability of infant motor profile

Conditions: Premature Infants; Cerebral Palsy; Down Syndrome; Metabolic Disorders; Spina Bifida; Low; Birthweight, Extremely (999 Grams or Less)

Summary: the aim of this study is to assess risky infants (or diagnosed infants) with infant motor profile, and analyze interrater and intrarater reliability of this test.

it is very hard to assess risky infants because of many problems like lack of cooperation, crying, discomfort ect. but with "infant motor profile (imp)" it is possible to assess motor behavior of risky infants in their daily environment. the assessment relays on video recordings so after recording the motor behavior many people can score the same children many times to have a certain idea about the infant. with this tool it could be easier to set a therapy program after determining the basic motor problem. in turkey there are a lot of risky infants which later have diagnosed with cerebral palsy, metabolic disorders and other diseases. also there are a lot of infants with down syndrome (ds) and spina bifida (sb). it has been known motor development is impaired with different childhood conditions but there is less information in literature about motor development of children with sb, ds and other diseases. with this study motor status of risky infants between 3- 24 months old will be explored, interrater and intrarater reliability of infant motor profile will be analyzed.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of cerebral palsy * clinical diagnosis of down syndrome * clinical diagnosis of spina bifida exclusion criteria: * uncontrolled epilepsy * severe congenital disorders

Keywords: risky infant cerebral palsy down syndrome spina bifida infant motor profile
everybody brush: a community-wide toothpaste distribution campaign

Conditions: Dental Caries

Summary: dental caries (tooth decay) is a disease with significant public health implications afflicting low-income children, with marked rural disparities in disease prevalence and treatment. more than 70% of 11th grade children in crook, deschutes and jefferson counties have experienced tooth decay. effective approaches to prevent decay include brushing with fluoridated toothpaste and professional dental care. medicaid enrolled children are legally entitled to dental care under early periodic screening, diagnosis and treatment (epsdt), yet \<50% had any care in 2010. free distribution of toothpaste and toothbrushes combined with parental education can increase toothbrushing frequency and reducing tooth decay. however, many parents are confused about when to start, how much and often toothpaste should be used, and how to overcome behavioral difficulties in brushing toddlers' teeth or getting older children to brush their own. the investigators' objective is to implement and evaluate a community-wide toothpaste distribution campaign enhanced by telephone support for ohp children and adolescents and their families in central oregon

a community-wide toothpaste distribution campaign enhanced by telephone support. a tooth kit with toothpaste and toothbrushes for the whole family together with oral hygiene instructions in english and spanish will be mailed every 3 months. half of the population will be randomly assigned to also receive telephone support (short message service and one-to-one calls). families will receive biweekly messages with oral hygiene tips. bilingual culturally competent staff will be available by telephone to support families in overcoming barriers.

Eligibility criteria:
inclusion criteria: * family speaks english or spanish exclusion criteria: * none

Keywords: children fluoridated toothpaste health education medicaid
finder® instrument and finder® flu a/b, rsv, sars-cov-2 test clinical evaluation protocol

Conditions: Influenza A; Influenza Type B; SARS CoV 2 Infection; RSV Infection

Summary: the goal of this observational study is to compare the finder flu a/b, rsv, sars-cov-2 test to an fda-cleared device. the study will utilize prospectively collected de-identified nasopharyngeal samples obtained from both pediatric and adult populations from subjects presenting with symptoms of respiratory illness. the main question it aims to answer are: • the study is to validate that the device intended use in terms that the device's performance meets the criteria for substantial equivalence with a predicate and satisfies the statutory criteria for clinical laboratory improvement amendments (clia) waiver.


Eligibility criteria:
inclusion criteria: * nasopharyngeal samples will be collected using swabs and placed in liquid transport media. * the samples are obtained from individuals exhibiting respiratory signs and symptoms. * these samples are collected as part of standard differential diagnostic procedures. * a minimum sample volume of 1.5 ml is required for testing purposes. exclusion criteria: * de-identified samples that have not been stored in accordance with cdc recommendations for nasopharyngeal (np) sample storage. * samples obtained from subjects who do not exhibit signs or symptoms of respiratory illness. * the sample with a volume is less than 1.5 ml
clinical use of a magnetic anal sphincter augmentation device, trade name fenix

Conditions: Fecal Incontinence

Summary: this registration is for clinical use of the fenix, a humanitarian use device (hud) for fecal incontinence. this device is indicated for the treatment of fecal incontinence in patients who are not candidates for or have previously failed conservative treatment and less invasive therapy options (e.g. bulking agents, radiofrequency ablation, sacral nerve stimulation).

the fenix is surgically placed. this surgery could be an outpatient procedure or at most an overnight stay in the hospital. the design of the device allows it to be effective immediately. the device is similar to the linx device used for esophageal reflux. it is a circular set of magnets which surrounds the ano-rectal support. the size of the device is determined at the time of surgery so that the ano-rectum is closed. when the patient strains at stool, this pressure separates the magnets and allows passage of stool. the magnets are held together by an independent malleable titanium wire. once straining at stool stops, the magnets are able to re-connect or close the rectum. we will monitor patients for postoperative complications related to surgery.

Eligibility criteria:
inclusion criteria: * non-pregnant female patients * 18 years of age or older with fecal incontinence * failed conservative therapy ( pelvic floor physical therapy, medications) and failed trial of interstim. exclusion criteria: * patients less than 18 years of age, * pregnant * previous radiation to pelvis, * chronic diarrhea or inflammatory bowel disease.