Kornimate/medical-research-clean huggingface dataset:
intensive activities-based locomotor training program in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: the goal of the proposed work is to investigate the impact of an intensive 3-week activities-based locomotor training (ab-lt) program on activity capacity, activity performance, and participation in children with cerebral palsy (cp). caregiver perspectives will provide a holistic assessment of the program.


Eligibility criteria:
inclusion criteria: * intervention: participants will be included if they have a diagnosis of cp and are between the ages of 2 to 12 years. they must also be enrolled in the 3-week ab-lt program at fortis therapy center. parent interview: participants will be included if they are the parent or guardian (any age) of a child who participated in the 3-week ab-lt program and attended at least 3 sessions with their child. exclusion criteria: * intervention study: participants will be excluded if they have had surgery or botulinum toxin injections in the previous 6 months or have uncontrolled epilepsy or cardiovascular disease. parent interview: participants will be excluded if they have not attended at least 3 ab-lt sessions with their child.

Keywords: cerebral palsy children activities-based locomotor training neuroplasticity
post marketing observational study (pmos) to assess quality of life in swedish hidradenitis suppurativa (hs) patients

Conditions: Hidradenitis Suppurativa

Summary: the objective of this study is to assess quality of life (qol), skin pain, work productivity/activity and health related problems in swedish patients with moderate to severe hs before and after 6 months treatment with adalimumab. participants will be treated in accordance with normal routine clinical care.


Eligibility criteria:
inclusion criteria: * diagnosis of hidradenitis suppurativa * prescribed adalimumab according to the summary of product characteristics (smpc) * willingness to sign and date a patient information/informed consent form exclusion criteria: * prior biologic treatment discontinued \<6 months before the baseline visit * patient not able to understand the language of the provided patient questionnaires * history of non-compliance with medication or a medical history that could enhance non-compliance with medication, as determined by the investigator

Keywords: quality of life
hypoperfusion-hypodensity mismatch for the identification of patients with stroke within 4.5 hours

Conditions: Acute Ischemic Stroke

Summary: intravenous thrombolysis is recommended within 4.5 hours of stroke onset. the aim of the study is to evaluate whether a hypodensity on native ct within the virtually entire area of hypoperfusion on perfusion ct, i.e. hypoperfusion-hypodensity mismatch, identifies patients within the time window of thrombolysis in a multicenter cohort. the investigators hypothesize hypoperfusion-hypodensity mismatch will identify patients ≤ 4,5 hours of symptom onset with \>70% specificity and \>85% positive predictive value.


Eligibility criteria:
inclusion criteria: * acute ischemic stroke * evidence of acute intracranial vessel occlusion (any supratentorial proximal or peripheral artery of the anterior cerebral artery, middle cerebral artery or posterior cerebral artery territory) by ct hyper dense thrombus and/or ctangiography vessel occlusion and/or by ischemic perfusion deficit * evidence for acute ischemic perfusion deficit, i.e. acute symptoms attributable to ischemic ct perfusion lesion * complete native ct and ctperfusion performed on admission * sufficient ct and ctperfusion quality for judgement of acute ischemic hypodensity * known time of symptom onset. exclusion criteria: * none
registry of haploidentical hematopoietic stem cell transplantation in adult with hematologic disease

Conditions: Multiple Myeloma

Summary: the goal of this observational study is to register hematologic patients with haploidentical hematopoietic stem cell transplantation (haplohsct). the main questions it aims to answer are: * 1-year progression free survival rate * 1-year overall survival rate * graft-versus-host free relapsed free survival at 30-day, 100-day, 180-day and 1-year * chronic graft-versus-host free relapsed free survival at 180-day and 1-year * rate of neutrophil and platelet engraftment * efficacy of donor specific antibody desensitization * relapsed rate * primary and late graft failure * safety and complication of haplohsct * complication of viral, bacterial, and fungal infection * viral reactivation * comparison outcomes between matched sibling donor (msd) hsct and matched unrelated donor (mud) hsct * comparison cost-effectiveness of treatment between matched sibling donor (msd) hsct and matched unrelated donor (mud) hsct participants will be collected the data of baseline diagnosis, treatment, treatment results of all admission and follow-up visits from hospital medical record.


Eligibility criteria:
inclusion criteria: * patients diagnosed with hematologic diseases indicated for treatment with haploidentical hematopoietic stem cell transplantation including 1. myeloid diseases (acute myeloblastic leukemia, myelodysplastic syndrome, chronic myelocytic leukemia, classical and non-classical myeloproliferative disorders) 2. lymphoid disease (acute lymphoblastic leukemia, lymphoma) 3. severe aplastic anemia * unable to find a matched sibling donor (msd) or matched unrelated donor (mud), and no alternative treatments * eastern cooperative oncology group (ecog) 0-2 * normal ast and alt, creatinine \&lt;2g/dl, and left ventricular ejection fraction ≥50% * age \&gt;18 years * capable of informed consent and provision of written informed consent before any study procedures * capable of attending all study visits according to the study schedule * female subjects who is childbearing potential must have a negative result for pregnancy test exclusion criteria: * hiv infection, active hepatitis b, active hepatitis c * active infection * history of other malignancy except basal cell carcinoma and carcinoma of the cervix in situ * a pregnant woman and/or refusal of contraception

Keywords: haploidentical hematopoietic stem cell transplantation (haplohsct) registry
a novel mat exercise program improves functional fitness, activity levels, and quality of life in older adults

Conditions: Physical Activity; Quality of Life; Functional Fitness

Summary: in this study, investigators recruited older adults aged 60 to 80 years and utilized a parallel experimental design. a total of 32 participants were randomly assigned to either the experimental or control group. the intervention consisted of a 70-min-long exercise game-based mat training session conducted twice weekly for 10 consecutive weeks. each session included a 10-min warm-up, approximately 45 min of primary training, and a 15-min cool-down and stretching routine. participants completed the international physical activity questionnaire (ipaq) and the world health organization quality of life questionnaire (whoqol, taiwanese version) before and after the intervention. additionally, the functional fitness assessment were conducted.

the mat-based exercise facility (stampede, taipei, taiwan) assists participants in exercise training by incorporating interactive light and sound effects to guide users through various exercises while progressively increasing intensity. the training program is divided into two phases: the first phase focuses on fundamental movements, whereas the second phase introduces more advanced exercises. with progress, additional exercise equipment is incorporated, along with increased sets, duration, movement variations, and training intensity. training sessions can be conducted in a simple, progressive manner or a game-competitive format. throughout the training, participants wore a heart rate monitor (alathec obeat1, taichung, taiwan) that recorded their exercise intensity and heart rate fluctuations. however, the exercise intensity and frequency were adjusted based on participants' adaptation. this study encompassed five different lighting modes, namely all light on, circle on, four corners, two lines, and diamond. each mode was paired with different training protocols and movement patterns, supplemented by training equipment, such as medicine balls, resistance bands, and balance pads.

Eligibility criteria:
inclusion criteria: (i) elderly individuals (aged 60-80) who have not experienced any muscle or skeletal injuries in the past month and are able to participate in training normally. (ii) completion of the physical activity readiness questionnaire and meeting the conditions for initiating moderate-intensity exercise intervention. (iii) ability to comply with the exercise frequency required by this study and travel to and from the training site independently. exclusion criteria: (i) individuals with severe musculoskeletal disorders, (ii) individuals deemed unsuitable for exercise training based on a physical activity readiness questionnaire evaluation or psychiatric disorders, and (iii) individuals under medications that may influence study outcomes.

Keywords: exercise game functional fitness sport technology physical activity stampede training
biotechcoach-forall: development of mental and physical exercise systems, clinical recording, supervisory analytical large-scale data and virtual guidance of vulnerable population groups

Conditions: Heart Failure

Summary: this would be a single center, parallel, two group randomized controlled pilot study that is designed to assess the feasibility and efficacy of the virtual coach program in elderly patients with heart failure.

this would be a single center, parallel, two group randomized controlled pilot study that is designed to assess the feasibility and efficacy of the virtual coach program in elderly patients with heart failure. sixteen (16) subjects will be enrolled to allow 8 subjects to be randomly assigned to each arm. the study will be conducted in thessaloniki/greece. the study is expected to complete enrollment in approximately 3 months. participants will be randomly randomized to either the intervention group (use of virtual coach program and usual care) or the control group (use of usual care alone) after successfully fulfilling all inclusion and exclusion criteria.

Eligibility criteria:
inclusion criteria: 1. male and female patients aged \>55 years old with any of the following conditions, diagnosed according to appropriate international guidelines criteria a) heart failure of any etiology, with either reduced or preserved ejection fraction 2. subjects must be in who functional class ii-iv 3. subjects must be on stable clinical condition and on stable medical treatment for the underlying disease for at least three months prior to randomization 4. willing and able to comply with scheduled visits, treatment plan, and trial procedures 5. evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study exclusion criteria: 1. patients with heart conditions other that those listed above 2. subjects who have unstable disease with evidence of decompensation, recent hospitalization or undergoing investigation for clinical deterioration 3. subjects with recent history of chest pain, palpitations, lightheadedness, dizziness, or syncope on exertion 4. subjects with contraindications to physical activity or with physical obstruction to perform the prescribed training program (eg patients confined on wheel chair etc) 5. subjects with any severe acute or chronic medical or psychiatric condition that may increase the risk associated with trial participation or may interfere with the interpretation of trial results 6. subjects who are investigational site staff members directly involved in the conduct of the trial and their family members, site staff members otherwise supervised by the investigator 7. subjects participating in any other experimental studies 8. subjects not willing to provide signed informed consent.

Keywords: heart failure exercise life coach
delirium treatment with acupuncture in internal medicine departments

Conditions: Delirium in Old Age

Summary: delirium frequently occurs in hospitalized older people, and treatment options are limited. acupuncture has been shown to reduce agitation in the setting of dementia. the investigators will test the hypothesis that it may also assist in treating delirium.

this randomized-controlled trial aims to evaluate the efficacy of acupuncture integrated with standard care as compared to standard care only for the treatment of delirium in hospitalized older persons. patients aged 65 and older, hospitalized in the internal medicine departments of bnai zion medical center and diagnosed with delirium or subsyndromal delirium will be randomized to either true acupuncture with usual care, or usual care only. daily treatments and outcomes' follow-up will be conducted up to one week from recruitment or until resolution of delirium or subsyndromal delirium for 48 hours. the primary outcome will be delirium resolution evaluated as time-to-first delirium remission (over 7 days) and the number of days spent delirium-free.side effects will be monitored daily.

Eligibility criteria:
inclusion criteria: * hospitalized in internal medicine department * aged over 65 years * delirium or subsyndromal delirium within the last 48 hours exclusion criteria: * platelet count under 20x10\^9/l * encephalopathy explained by a cause other than delirium (acute stroke, alcohol, cirrhosis, etc.) * history of severe dementia * communication barriers preventing delirium assessment
evaluation of an early support programme in orthophony

Conditions: Language Development Disorders; Preterm Birth

Summary: prospective, interventionnal with minimal risks and constraints, multicentric, non-randomized, open study, to measure the impact of an early support programme in speech and language therapy for vulnerable children (papev-ortho), in children born very prematurely or very hypotrophically, on the incidence of language and communication deficits at the corrected age of 2 years.

prospective, interventionnal with minimal risks and constraints, multicentric, non-randomized, open study, to measure the impact of an early support programme in speech and language therapy for vulnerable children (papev-ortho), in children born very prematurely or very hypotrophically, on the incidence of language and communication deficits at the corrected age of 2 years. parents of eligible children are informed of the study either during the hospitalization of the neonatal newborn by a hospital physician, or during a consultation performed during the first 6 months by a pilot physician from the rpsof-asnr network, hospital or private practitioner. parents who agree that the data collected about their child may be used in the study sign a written declaration of free and informed consent. the early support programme in orthophony (papev-ortho) is systematically proposed to families with possible access to a language therapist in the network. early support in speech therapy lasts between 6 months and 24 months of corrected age. it includes 10 to 20 sessions depending on the child's needs. these sessions are conducted by a speech-language pathologist from the rpsof-asnr network, trained in the issues specific to the very premature child and the network's tools. the support focuses on: * the development of parental sensitivity and receptivity * the development of parental reactivity * optimization of communication sequences in routine acts and play * the development of the child's intentionality in play and routine acts * support for verbal and non-verbal oral communication the participation of the child and his or her parents in the study ends at the end of the consultations and evaluations carried out at 24 months of corrected age. children within the group that followed the papev-ortho program will be compared to children who did not benefit from this program.

Eligibility criteria:
inclusion criteria: * premature birth \< 32 weeks of amenorrhea * or premature birth with intrauterine growth restriction (iugr) \< p3 * corrected age ≤ 6 months at the time of inclusion * affiliation to a social security system + mutual insurance exclusion criteria: * genetic pathology * ongoing developmental care: psychomotricity or speech therapy * neuromuscular pathology affecting oral and facial motor skills * severe oral disorders: feeding by gastric tube or gastrostomy * severe sensory, auditory or visual impairment * neither of the 2 french-speaking parents

Keywords: language development communication development preterm infant orthophony
bipolar intervention study: cognitive interpersonal therapy

Conditions: Mania; Hypomania; Bipolar Affective Disorder

Summary: there is a need to develop a better understanding of the early phase of bipolar disorder, and to develop and evaluate effective psychosocial interventions that assist people in this phase. the purpose of this study is to determine whether or not it is feasible to conduct a larger study of the effectiveness of cognitive interpersonal therapy (a psychological therapy) with individuals who have experienced their first or second treated episode of mania or hypomania (symptoms common in early development of bipolar disorders).

the 'pico' framework (oxman, sackett, and guyatt, 1993; richardson, wilson, nishikawa, and hayward; 1995) was used to specify the parameters of the study aims and objectives: 1. population: could appropriate individuals be identified and recruited to a trial of cit for early bipolar disorder? 2. intervention: would cit be an acceptable intervention for individuals following a first or second treated episode of mania and or hypomania? could we identify any modifications required to the cit protocol used with this group? 3. control group: could an appropriate group of participants be recruited to facilitate a comparison with the cit intervention? could we explicitly establish the usual care package and its local implementation? 4. outcomes: which outcomes are appropriate for measuring relevant dimensions of a treatment effect?

Eligibility criteria:
inclusion criteria: * eligible individuals will have experienced their first or second treated episode of mania and / or hypomania in the previous 12-months prior to study entry. exclusion criteria: * participants will be excluded if there is a (1) diagnosis of learning disability; (2) inability to participate in psychotherapy/research due to acute medical condition or acute mania

Keywords: mania hypomania bipolar affective disorder psychological intervention cognitive therapy
effects of virtual reality on rehabilitation in patients with heart failure

Conditions: Heart Failure; Reduced Ejection Fraction

Summary: background. to improve symptoms and reduce poor outcomes related to heart failure (hf), international guidelines recommend cardiac rehabilitation (cr), particularly for those with a reduced ejection fraction. unfortunately, patient adherence to rehabilitation programs remains suboptimal, with dropouts ranging from 15.4 to 63.3%. an innovative and promising intervention that could improve adherence to rehabilitation is virtual reality (vr). this study aims to evaluate the effects of vr in patients with hf undergoing cr in terms of adherence (primary outcome), functional capacity, perceived exertion, angina, quality of life, heart rate, oxygen saturation, blood pressure, maximum oxygen uptake, minute ventilation/carbon dioxide production slope, oxygen pulse, blood values of nt-probnp and rehospitalization rates due to hf (secondary outcomes). methods. a randomized controlled trial will be conducted in a sample of 80 patients referred to cr. participants will be enrolled in a cardiological rehabilitation unit of a large university hospital in italy and randomized (1:1) to the experimental intervention consisting of cr performed with high-quality immersive vr with pico 4® head mounted display headset and treadmill xr® software (arm 1) or standard cr (arm 2). patients will receive 30-minute cr sessions twice a week for one month. results. significant improvements in primary and secondary outcomes are expected in patients in the intervention group. conclusions. if proven to be effective, vr could be an innovative, safe, and easy digital health intervention to improve adherence to cr in patients with hf, as well as important clinical outcomes.


Eligibility criteria:
inclusion criteria: * age over 18 years; * clinically stable chronic hf diagnosis with left ventricular ejection fraction (lvef) \< 40% exclusion criteria: * conditions that exclude exercise training (e.g., bone fractures); * conditions that exclude vr use of vr (e.g., blindness and deafness * severe cognitive impairment, documented with a score of 0 - 4 on the six-item screener; * end-stage renal disease requiring dialysis; * ascertained advanced pneumopathies; * active neoplasms; * rheumatic diseases.

Keywords: heart failure cardiac rehabilitation virtual reality treatment adherence and compliance randomized controlled trial
self-collected swabs for hpv testing in 18-24 year old women

Conditions: Papillomavirus Infections

Summary: the purpose of this study is to compare methods for transporting self-collected swabs for hpv testing in 18-24 year old women and to look at risk factors for hpv infection in 18-24 year old women.

we propose a cross-sectional study among 150 women in the united states who have used internet dating sites in the past year in order to examine risk factors for high-risk hpv infections in 18-24 year old online daters, and evaluate strategies for transporting and storing self-collected samples for hpv testing. we will ask participants to complete a written questionnaire on their health, sexual behavior, and attitudes toward self-collecting vaginal swabs, hpv vaccination, and cervical cancer screening. also, we will ask the women to self-collect two sequential vaginal swab samples that will be transported and stored according to the two strategies described above. each sample will be tested for type-specific hpv dna using a pcr-based assay.

Eligibility criteria:
inclusion criteria: * have had sex with men * have used the internet to search for romantic partners in the past year (e.g. posted or responded to an ad on an internet dating website or social networking website) exclusion criteria: * pregnant or breastfeeding