Kornimate/medical-research-clean huggingface dataset:
delayed cord clamping in infants born by 'two-step' vaginal delivery

Conditions: Placental Transfusion; Hematocrit Anemia

Summary: the investigators conducted a rct (parallel group study with 1:1 randomisation) comparing ecc (at 60 seconds) and dcc (at 180 seconds) in 90 cases of normal birth by' two-step' delivery. in term infants born by' two-step' delivery, dcc results is a higher blood volume in the newborn and facilitates the maternal-placental-fetal exchange of circulating compounds, without potentially detrimental neonatal outcomes.

introduction: placental transfusion supports an important blood transfer to the neonate, promoting a more stable and smooth transition from fetal to extra-uterine life with the potential to prevent iron deficiency in young children. several studies have demonstrated that cord clamping timing is greatly relevant for facilitate placental transfusion, the transfer of extra blood from the placenta to the infant in the third stage of labor. therefore, during natural 'two-step' delivery umbilical cord management may play a relevant role on blood passage to the neonate and it may affect neonatal hematological values and placental transfusion. the most effective way to manage umbilical cord in in 'two-step' delivery remains to be established. objective: the aim of the present study is to evaluate the effect of two different methods of umbilical cord management (early cord clamping - ecc vs. delayed cord clamping - dcc) on the placental transfusion, defined by in two-step delivery, by ∆ haematocrit (hct) from arterial cord blood at birth and capillary blood at 48 h of age. accounting for physiological body weight decrease. secondary outcomes included contemporary estimate of blood gases, lactate, and glucose concentrations in arterial cord blood gas analysis. material and methods: this is a randomized clinical trial on the effect of different cord management newborns born by 'two-step' delivery. after obtaining parental consent, all mothers \> 38 weeks' gestation will be assigned to either ecc or dcc group in a 1:1 ratio according to a randomized sequence generated by an opened, sealed, numbered, opaque envelope containing the cord clamping interventions allocation, ecc (at 1 minute) or dcc (at 3 minutes after delivery).

Eligibility criteria:
inclusion criteria: vaginal delivery gestational age \>37 weeks natural process of labor exclusion criteria: cesarean section fetal distress major isoimmunisation ccongenital diseases cord abnormalities.

Keywords: placental transfusion two-step delivery early cord clamping delayed cord clamping
biomarkers in tumor tissue samples from patients with peripheral t-cell lymphoma or natural killer cell neoplasms

Conditions: Lymphoma

Summary: rationale: studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. it may also help doctors find better ways to treat the cancer. purpose: this research trial studies biomarkers in tumor tissue samples from patients with peripheral t-cell lymphoma or natural killer cell neoplasms.

objectives: * to identify mutations in oncogenes and tumor suppressors of peripheral t-cell lymphoma or natural killer (nk) cell neoplasm. * to delineate the mechanisms that mediate oncogenic effects and their clinical prognostic significance in these diseases. * to perform a comprehensive mutation analysis via whole exome resequencing in a panel of peripheral t-cell or nk lymphomas. outline: fixed paraffin-embedded tumor tissue samples are analyzed for mutations by the illumina hiseq platform. sequencing reads are performed by gapipeline version 1.5.1 and mapping on the human genome performed using the maq software version 0.7.1. genes harboring validated somatic mutations are then amplified by pcr and analyzed by sanger resequencing.

Eligibility criteria:
disease characteristics: * diagnosed with peripheral t-cell lymphoma or natural killer cell neoplasms * available fresh tumor samples from patients treated on ecog-e2404 and normal dna (non-ecog) samples patient characteristics: * not specified prior concurrent therapy: * see disease characteristics

Keywords: peripheral t-cell lymphoma stage i adult t-cell leukemia/lymphoma stage ii adult t-cell leukemia/lymphoma stage iii adult t-cell leukemia/lymphoma stage iv adult t-cell leukemia/lymphoma anaplastic large cell lymphoma
preventive approach for the management of the main geriatric risks

Conditions: Geriatric Syndromes

Summary: nowadays, ehpad residents are polypathological (cognitive and psycho-behavioral pathologies, undernutrition, ic, diabetes, copd, ir, etc.) and multi-medicated. from a medical point of view, this implies the need for regular monitoring and a high level of medical or even multidisciplinary expertise for the healthcare team. the objective of the ger-e-tec ™ project is to provide these complex patients with telemedicine tools allowing protocolized and personalized, non-intrusive monitoring. the ger-e-tec ™ project more specifically takes into account the significant issues in nursing homes of aging residents with the main geriatric syndromes (fall, undernutrition, cognitive-behavioral disorders, iatropathogeny, etc.) the objective of the work undertaken is to develop a codified preventive approach for the management of the main geriatric risks, in order to avoid the occurrence of an acute decompensation factor in the elderly.


Eligibility criteria:
inclusion criteria: * major subject (≥65 years old) * subject hospitalized between june 17, 2019 to november 13, 2019, in the uf 3723 department, of the medical clinic b of the university hospitals of strasbourg * having not expressed his opposition, after information, to the reuse of his data for the purposes of this research. exclusion criteria: * subject having expressed opposition to participating in the study * impossibility of providing the subject with enlightened information (difficulties in understanding the subject, etc.) * subject under guardianship or guardianship * subject under safeguard of justice * subject in palliative / end of life situation * subject in acute emergency situation

Keywords: geriatric syndromes psycho-behavioral pathologies undernutrition, diabetes
clinical course and treatment of covid-19 inpatients in hospital

Conditions: COVID-19

Summary: the study is an epidemiological observational study. it serves to collect data from patients with positive covid-19 test results who are hospitalized. all data describing the course of the inpatient stay are recorded (length of stay, course of therapy, medication, x-ray and ct results,ventilation mode and duration, laboratory). furthermore, anthropometric data and information on covid-19 symptoms is recorded.

the aim of this study is to describe the course of disease and the treatment of patients suffering from covid-19 who are hospitalized and treated as inpatients: 1. are there common features (previous illnesses, medication, age, bmi, etc.), which may influence the course of disease? 2. are there therapeutic procedures that have a positive or negative impact on the course of the disease or the length of stay in the intensive care unit/ the duration of ventilation (early/late intubation, cpap, niv, ecmo)?

Eligibility criteria:
inclusion criteria: * positive covid-19 test result * age \> 18 years exclusion criteria: * age \< 18 years * negative covid-19 test result * lack of agreement * any medical, psychological or other condition, that restricts the ability of the person to be informed and to give the consent for voluntary participation in this trial
observational bronchoscopy video data collection study with adult patients

Conditions: Lung Diseases; Lung Neoplasms; Lung Cancer; Lung Transplantation; Lung Diseases, Obstructive

Summary: the primary aim is to develop a software algorithm that has the capacity to detect the normal 18 anatomical structures of the lung by using the position of the scope during the bronchoscopy procedure and using existing bronchoscopy technology.

a data collection of bronchoscopy videos from 100-150 patients are enrolled for getting image material of different lung anatomies, captured with ce-marked and fda-approved ambu bronchoscopes (ambu® ascope™ 5 broncho hd). no intervention will take place, only standard of care. all types of indications are enrolled. all patients were given oral and written information prior to participating, and signed consent was provided. no patient identifiable information is stored.

Eligibility criteria:
inclusion criteria: * patients indicated for bronchoscopy of central airways as per standard of care * patients of 18 years or above exclusion criteria: * lack of patient cooperation for bronchoscopy (e.g. patients with mental disorders, dysgnosia, psychological disorder) * patients unable or unwilling to give informed consent
move to music video intervention for icu survivors

Conditions: Critical Illness; Intensive Care Unit Syndrome

Summary: the purpose of this study is to determine if exercising with a music video program will improve physical functions of patients who have been discharged from an intensive care unit (icu).


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old; 2. length of icu stay \>5 days (excludes patients with less comorbidity); 3. recruitment within 48 hours of icu discharge (standardizes time to begin intervention); 4. able to independently move upper and lower extremities (required to participate in intervention); 5. cognitively able to complete the assessments and comply with physical testing instructions; 6. able to speak english or spanish; and 7. reside at home prior to icu admission. exclusion criteria: 1. documented mental incompetence; 2. dependent status pre-icu admission (assessed by the katz index of independence in activities of daily living); 3. evidence of delirium assessed using the confusion assessment method; 4. hearing impairment; 5. documented "comfort measures only" or impending death; 6. prior residence in a long-term care facility; and 7. unstable clinical measures defined as heart rate (\>140 beats/minute) or respiratory rate (\>35 breaths/minute), blood pressure (systolic blood pressure \>180 mmhg or \< 90mmhg), ventilation problems, agitation, or perspiration. we will not enroll adults unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant women, and prisoners.
paracervical block in first trimester surgical abortions

Conditions: Pain; Surgical Abortion

Summary: the investigators primary objective is to study the analgesic effects of combined ketorolac and lidocaine in a paracervical block compared to preoperative ibuprofen followed by intra-operative paracervical block with lidocaine alone on women undergoing first trimester surgical abortions. the investigators hypothesize that women who receive a paracervical block of combined ketorolac and lidocaine will experience less pain during the procedure based on a visual analog scale (vas) compared to those who receive preoperative ibuprofen and a paracervical block with lidocaine alone. this randomized, multi-site, placebo-controlled clinical trial will investigate the difference in perceived pain from first trimester surgical abortions using a paracervical block of combined ketorolac and lidocaine compared to preoperative ibuprofen and paracervical block with lidocaine alone. a total of fifty women who are seeking elective surgical abortions of intrauterine pregnancies less than 11 0/7 weeks' gestation will be recruited from johns hopkins bayview medical center, planned parenthood of maryland in baltimore, maryland and planned parenthood columbia-willamette in portland, oregon. pain before, during, and after surgical abortion will be measured using a 100-mm vas. the primary outcome of interest is the mean difference in pain level from preoperative baseline to time after cervical dilation comparing the treatment groups. if the investigators see greater pain reduction associated with the paracervical block of lidocaine and ketorolac, adoption of this regimen may improve pain management during first trimester surgical abortions. if combined ketorolac and lidocaine when administered as a paracervical block is proven to be efficacious, the need for additional analgesia in first trimester surgical abortions can be minimized.


Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * english-speaking * ability and willingness to sign the informed consent * ability and willingness to comply with the terms of the study * voluntary request for pregnancy termination * ultrasound-confirmed singleton intrauterine pregnancy with an estimated gestational age not exceeding 76 days (10 6/7 weeks) from the first day of the preceding menstrual cycle exclusion criteria: * women who require or request sedation * untreated acute cervicitis or pelvic inflammatory disease * contraindications to lidocaine such as allergy to lidocaine, cardiac arrhythmia or heart block, and porphyria * allergic reaction or sensitivity to lorazepam or nsaids * chronic nsaid use * history of gastritis or gastric ulcer * acute renal failure or chronic renal disease * chronic liver disease * history of bleeding diathesis * chronic narcotic use * current or past history of illegal drug use (excluding marijuana)

Keywords: pain associated with first trimester surgical abortion
hyaluronic acid for soft tissue injuries

Conditions: Elbow Tendinopathy; Ankle Sprains

Summary: soft tissue adapted biocompatible hyaluronic acid, or stabha™, has demonstrated varying degrees efficacy in patients treated for common musculoskeletal tendinopathies and ligament injuries, such as ankle sprains, lateral elbow tendinopathy, and rotator cuff tendinopathies. factors associated with prognosis following treatment remain largely unknown. identifying appropriate patient populations for use of stabha™ is a necessary first step to facilitate the design of future clinical trials in the management of acute and chronic musculoskeletal soft-tissue injuries.


Eligibility criteria:
inclusion criteria: 1. patients 18 years of age or older. 2. having a stabha™ injection for the treatment of: 1. acute first or second degree ankle sprain (e.g. occurred within the past 48 hours). 2. lateral epicondylitis (tennis elbow). 3. informed consent obtained. exclusion criteria: 1. medical contraindication to stabha™. 2. previous treatment with stabha™. 3. ankle or foot fracture. 4. bilateral ankle sprain. 5. previous ankle sprain in the past 12 months. 6. prior surgical management of the ankle or elbow. 7. current or anticipated incarceration. 8. terminal illness with expected survival less than 90 days. 9. currently enrolled in a study that does not permit co-enrollment. 10. unable to obtain informed consent due to language barriers. 11. unable to comply with the protocol. 12. problems, in the judgment of study personnel, with maintaining follow-up with the patient. 13. prior enrollment in the study. 14. other reason to exclude the patient, as approved by the sponsor.
web-based motor intervention to increase health related physical fitness in children with congenital heart disease

Conditions: Congenital Heart Disease; Health Related Physical Fitness; Motor Skills; Cardiovascular Prevention

Summary: children with congenital heart diseases (chd) often show reduced health related physical fitness as well as limitations in gross and fine motor skills/development. intervention programs in childhood are still rare and often focus just on the improvement of cardiac outcomes or exercise capacity. web-based interventions, as a useful alternative to training manuals or supervised training, are cost effective and allow a customization of training times. primary purpose of this study is to improve health related physical fitness in children with congenital heart disease.


Eligibility criteria:
inclusion criteria: * ages 10-18 years old. * chd with moderate to complex severity according to the acc criteria. * health-related physical fitness \<50th percentile (healthy reference). * german speaking. * internet availability and an internet-capable device to use the intervention app * informed consent of parent/guardian as well as of the child. exclusion criteria: * severe arrhythmias * severe left heart failure * chromosomal anomalies and/or genetic syndromes. * severe physical and/or sensory impairments (hearing, visual, or psychomotor). * elective cardiac intervention within the next 6 months following enrollment.
proposed research protocol for male infertility

Conditions: Male Infertility

Summary: the purpose of this experiment is to test the feasibility of a minimally interventionist protocol for young couples with male factor infertility, which addresses the cause of infertility for these couples which is the inability of the sperm to fertilize the egg.ultrasound monitoring of natural follicular development utilizing rfsh, gnrh antagonist and rhcg only for the final maturation. single follicle aspiration and iui or ivf/icsi based on sperm charcteristics on the day of fertilization. fertilized eggs transfered to the uterus on the same day as the aspiration.


Eligibility criteria:
inclusion criteria: 1. couples with "pure" male factor infertility of six months or more, defined as not pregnant in spite of being desirous of pregnancy for at least six months with normal sexual activity and no birth control. primary and secondary infertility included. 2. abnormality of any one of the sperm parameters according to who or kruger for concentration, motility or morphology. 3. women aged 18 to 30 with a bmi between 18 and 30 4. women who testify that they are healthy with regular menstrual cycles between 25-35 days per cycle. exclusion criteria: 1. uterine fibroids or ovarian cysts or tumors or suspected hydrosalpinx on us on prior fertility workup. paraovarian simple cysts, ok. 2. prior pid, abdominal or pelvic surgery or abnormal hsg if done. 3. known allergy to medications used in protocol 4. diagnosed or suspected genetic or psychiatric disease in either patient. 5. azoospermia 6. female partner with a history of infertility with another partner 7. elevated fsh (over 10 units/l) in female partner if done.

Keywords: male infertility natural cycle ivf in-vitro fertilization intrauterine inseminatio
the clinical profile of parkinson disease in egypt

Conditions: Parkinson's Disease

Summary: multi-center, retrospective observational cohort study in 4 tertiary referral centers in cairo over the period from 2004 to 2016. study population. including all patients with idiopathic parkinson disease attending. patients were diagnosed in accordance to the united kingdom - parkinson disease society brain bank criteria.

retrospective, observational study that involve medical record review (mrr). data extraction and collection from medical records was organized through an electronic structured data collection form by two of authors (h.s and n.s). the abstraction documents included; patient's age, sex, family history, age at onset, type and side of motor symptoms onset, associated non-motor manifestations. moreover; management plan, drug history, outcome and disease progression were also verified and recorded. during medical record reviewing (mrr); any missing documentation or poorly recorded information was managed by deleting the case.

Eligibility criteria:
inclusion criteria: * all patients with parkinsonian syndromes exclusion criteria: * records with missing operationalized variables from patient records
safety and efficacy of oral bovine lactoferrin

Conditions: Neonatal SEPSIS

Summary: oral lactoferrin versus placebo will be given to preterm neonates

200 patient were included in the study , one hundred received oral placebo in the form of 2 ml saline , the other 100 preterm neonates received oral lactoferrin with monitoring of c-reactive protein , different cultures, complete blood count on day 7 and after one month.

Eligibility criteria:
inclusion criteria: all neonates born at cairo university hospital nicu exclusion criteria: * neonatal deaths before 3 days postnatal . * neonates with underlying gastrointestinal problems that prevent oral intake. * neonates with major congenital anomalies . * neonates with severe hypoxic ischemic encephaloapathy . * neonates whose parents refuse to participate.

Keywords: lactoferrin
evaluation of systolic function in heart failure with middle ejection fraction by 3d speckle tracking imaging

Conditions: Heart Failure

Summary: in 2016, the european heart association defined the median ejection fraction heart failure for the first time. more research is needed to improve our understanding of this population, so as to make the best clinical decision and improve the prognosis. in this study, 3d-sti was used to evaluate left ventricular systolic function in heart failure with median ejection fraction.

as the final manifestation of cardiovascular disease and the main cause of death, heart failure is one of the important challenges threatening human health in the 21st century. in 2016, the european heart association proposed a new classification standard for heart failure. in particular, for the first time, heart failure with median ejection fraction has been clearly defined. these patients have received more and more attention, but there are still relatively few studies on them. more research is needed to improve our understanding of this part of the population in order to make the best clinical decisions and improve the prognosis. 3d speckle tracking technology is a new technology developed on the basis of real-time three-dimensional echocardiography and speckle tracking technology. it is gradually recognized in the evaluation of left ventricular systolic and diastolic function, especially in the evaluation of cardiotoxicity of chemotherapy drugs. at present, the application of 3d-sti in the evaluation of left ventricular systolic function in heart failure with median ejection fraction is limited and needs further study.in this study, 3d-sti was used to evaluate left ventricular systolic function in heart failure with median ejection fraction.

Eligibility criteria:
inclusion criteria: meeting the diagnostic and classification criteria of heart failure proposed in the 2016 esc guidelines for the diagnosis and treatment of acute / chronic heart failure exclusion criteria: 1. acute or chronic infectious diseases; 2. copd, chronic bronchitis, emphysema and other serious lung diseases; 3. autoimmune diseases; 4. malignant tumor; 5. acute, chronic liver disease or other reasons lead to abnormal liver function (transaminase is more than 3 times of normal value); 6. acute and chronic kidney disease, end-stage renal disease (serum creatinine \> 220 μmol/l, or creatinine clearance rate \< 30 ml/min); 7. heart valve disease; 8. severe arrhythmia; 9. the image quality of echocardiography was poor when it was larger than three sections;

Keywords: median ejection fraction 3d-sti