Kornimate/medical-research-clean huggingface dataset:
carpal tunnel syndrome in pregnant women

Conditions: Carpal Tunnel Syndrome; Exercise

Summary: the purpose of our study is to evaluate the effectiveness of the home exercise program in patients who develop carpal tunnel syndrome (cts).

materials and method: thirty-three patients with cts (mild to moderate) were included to randomized, single-blind, controlled clinical trial. based on emg results and clinical examination, patient group was divided two part as mild and moderate cts (group 1) and normal (group 2). the sick boston carpal tunnel syndrome questionnaire form was filled in face-to-face method. cases in this study: patients who had pain and numbness problems at the hands of the bezmiâlem vakif university polyclinic for women and obstetrics were then directed to the bezmiâlem vakif university physical therapy rehabilitation policlinic. after the examination and clinical testing of each patient (tinel test, phalen's test, reverse phalen's and durkan's carpal compression test), the patients were directed to bezmiâlem vakif university neurology policlinic. based on electromyography (emg) results and clinical examination, the group was classified as mild and moderate cts (group 1) and normal (group 2). a disease exercise form was distributed for all patients to do exercises.

Eligibility criteria:
inclusion criteria: * provocation tests during the examination and physical examination to match the median nerve distribution those who have symptoms of numbness, tingling, weakness and pain in the hands that have lasted at least 1 month. * patients with confirmed mild-moderate idiopathic cts on emg. exclusion criteria: * previously undergone carpal tunnel surgery * gestational diabetes mellitus, * eclampsia, preeclampsia * thyroid disorders * arthropathies * hand or wrist trauma * bilateral fractures * severe cts * atrial fibrillation * cervical radiculopathy * peripheral neuropathy * thoracic outlet syndrome * diabetes mellitus * hypothyroidism * hyperthyroidism * rheumatologic disease

Keywords: carpal tunnel syndrome home exercise pregnant women
combined sensitivity and specificity of cortical lesions and central vein sign for ms diagnosis and differential diagnosis

Conditions: Multiple Sclerosis)

Summary: this study investigates the specificity/sensitivity of the combined presence of cortical lesions (cls)/leuco-cortical lesions (lcls) and central veins sign (cvs) for multiple sclerosis (ms) diagnosis and differential diagnosis.

cls and lcls may be detected at 3 tesla (t) mri by using dedicated sequences. 3d double inversion recovery (dir), phase-sensitive inversion recovery (psir), magnetization prepared - rapid gradient echo (mprage) and magnetization prepared - 2- rapid gradient echo (mp2rage) have all shown variable sensitivity to cls and lcls. the central vein sign (cvs, i.e. the detection of a central vessel in a focal lesion) has been recently proposed as a biomarker for distinguishing between ms and not and not ms. both the presence of cl and cvs brings high sensitivity and specificity in distinguishing ms from not ms patients; whether their combination achieves higher sensitivity and specificity to ms diagnosis and differential diagnosis is to date not know. this study investigates the specificity/sensitivity of the combined presence of cortical lesions (cls)/leuco-cortical lesions (lcls) and central veins sign (cvs) for multiple sclerosis (ms) diagnosis and differential diagnosis.

Eligibility criteria:
inclusion criteria: * clinical and mri data of patients with ms or ms mimics (migraine, vasculitis, diabetes, neuromyelitis optica spectrum disorder) * mri data must have been collected at 3t between 1990 and 2020 and must include t1 w, t2 w, t2-star based sequence (cvs detection) and dir/psir/mp2rage (eventually also high spatial resolution mprage) for cortical lesion detection exclusion criteria: * unavailability of institutional informed consent * unclear diagnosis * other neurological or psychiatric diseases.

Keywords: cortical lesions leuco-cortical lesions central vein sign
long-term follow-up of gene therapy for radiation-induced xerostomia

Conditions: Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

Summary: this study will assess the long-term safety and efficacy of bilateral intra-parotid administration of aav2-haqp1 in adults with grade 2 or grade 3 radiation-induced late xerostomia.

individual participation in this study will last approximately 48 months for participants who received aav2-haqp1 in study mgt-aqp1-201 and at least 60 months for participants who receive aav2-haqp1 in study mgt-aqp1-202.

Eligibility criteria:
inclusion criteria: * received study drug in study mgt-aqp1-201 exclusion criteria: * withdrew consent to participate in study mgt-aqp1-201.
comparison of binocular spectacle prescription versus patching therapy in refractive amblyopia patients

Conditions: Amblyopia

Summary: this study will examine on refractive amblyopia patients, whose amblyopia started due to longstanding uncorrected refractive errors.

there will be a comparison of two treatment methods i.e. patching and binocular spectacle prescription used to cure amblyopia patients. in binocular spectacle correction, we will slightly blur the good eye and fully correct the amblyopic eye so that binocular functions stimulate and improve after the treatment. literature suggests that patching improve monocular functions but there is no significant improvement in binocular functions.

Eligibility criteria:
inclusion criteria: * anisometropic amblyopia * anisometropia \> 1.00 d( difference between eyes in se) * astigmatism \>1.50 d * va in amblyopic eye 20/40 -20/200(6/12-6/60) or less than 20/200 * va in the better eye or fellow eye 20/30 (6/9) or better exclusion criteria: * strabismic amblyopia * deprivation amblyopia * isoametropic amblyopia * history of ocular trauma, iol implant * media opacity * any ocular/retinal pathology * optic nerve pathology * ptosis * any gaze control abnormalities
tysabri observational program

Conditions: Relapsing-Remitting Multiple Sclerosis

Summary: the primary objective of this study is to assess the long-term safety and impact on disease activity and progression of tysabri in participants with relapsing remitting multiple sclerosis (rrms) in a clinical practice setting.

top is an epidemiological observational study of participants receiving natalizumab, with each participant to be followed for up to 15 years. this study is designed to address the long-term safety profile and the long-term impact on disease activity and progression of tysabri with marketed use, and the impact of treatment on disability in particular by comparing the results with prospectively determined controls from established databases.

Eligibility criteria:
key inclusion criteria: * documented diagnosis of relapsing remitting multiple sclerosis * the decision to treat with tysabri must precede enrollment * patient must be a new tysabri user, and must not have had more than 3 tysabri infusions prior to enrollment * must have had at least one relapse in the previous year, and must satisfy locally approved therapeutic indications for tysabri key exclusion criteria: * history of progressive multifocal leukoencephalopathy or other opportunistic infections, or an increased risk of opportunistic infections * history of positive anti-tysabri antibodies * concomitant immunomodulatory or immunosuppressive therapy during therapy with tysabri * patient immunocompromised at the time of enrollment * known active malignancy * women must not be breast feeding or pregnant, or planning to become pregnant (must use birth control unless surgically sterile) note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: disease progression multiple sclerosis disease activity tysabri natalizumab long-term safety
comparison of robot assisted gait training and body weight supported treadmill training using gait analysis and semg measurements

Conditions: Stroke, Ischemic

Summary: the aim of our randomized controlled clinical trial was to analyze the effects of robotic-assisted gait training and body-weight-supported treadmill training on gait analysis parameters and lower extremity agonist and antagonist muscle activities in stroke patients and to compare their effectiveness in improving locomotor function. the main questions that the researchers aimed to answer are: what are the effects of robotic-assisted gait training and body-weight-supported treadmill training on gait analysis parameters in stroke patients? what are the effects of robotic-assisted gait training and body-weight-supported treadmill training on lower extremity agonist and antagonist muscle activities in stroke patients? what is the effectiveness of robotic-assisted gait training and body-weight-supported treadmill training in improving locomotor function in stroke patients? the patients included in the study were randomly divided into three groups: the first group received robotic-assisted gait training with robogait, the second group received body-weight-supported gait training on a treadmill with rehawalk, and the third group received conventional walking training.


Eligibility criteria:
inclusion criteria: * age 18 and above * chronic stage stroke (6 months - 2 years) * first stroke * spasticity of ashworth stage 2 or lower * ability to follow commands * ability to walk unsupported for more than 10 meters * no treatment received in the last month exclusion criteria: * severe osteoporosis * unstable fracture * excessive spasticity (ashworth stage 3 and above) * cognitive impairment

Keywords: stroke rehawalk robogait
sensory retraining facilitates sensory recovery after mandibular nerve injury

Conditions: Injury of Trigeminal Nerve; Surgery; Mandibular Prognathism

Summary: the purpose of this study is to determine whether sensory retraining exercise could improve lip numbness caused by bilateral sagittal split of mandible.

the study is a prospective randomized controlled trial. the patients receiving bilateral sagittal split osteotomy and having lip numbness or paraesthesia will be included in this study. 80 patients will be included and randomized into two groups and there are 40 patients in each group. the control group is to maintain follow up in clinic and do not receive any sensory retraining exercise. the experimental group is requested to perform sensory retraining at home by themselves.

Eligibility criteria:
inclusion criteria: 1. taiwanese adult (18-40 y/o) 2. developmental dentofacial disharmony (class iii) 3. patients received orthognathic surgery (bsso alone or with maxillary procedure) exclusion criteria: 1. medical condition associated with systemic neuropathy 2. unwilling to sign informed consent 3. congenital anomaly or acute trauma affecting the face 4. previous facial surgery 5. positive pain sensation at first week of post-surgery 6. altered sensation before ogs as numbness or unusual feeling 7. cleft lip and palate

Keywords: mandibular nerve orthognathic surgery sagittal split osteotomy sensory retraining
school-based bladder health intervention

Conditions: Urinary Dysfunction; Lower Urinary Tract Symptoms; Urinary Tract Infections; Urinary Tract Infections in Children

Summary: the aim of this study is to promote healthy bladder behaviors among school children. we hypothesize that a combination of bladder health education and awareness events, additional resources such as a water station to support healthy bladder behaviors, and tailored changes to classroom bathroom policies can promote healthy bladder behaviors among school children.

in order to promote healthy bladder behaviors among school children, we will conduct a randomized control trial in schools. the research team will provide support for a combination of bladder health education and awareness events, additional resources such as a water station to support healthy bladder behaviors, and tailored changes to classroom bathroom policies that are tbd (e.g. mobile technology bathroom passes). the study will involve 4-8 fourth grade classrooms within 2 elementary schools that meet the historical criteria for \>50% students receiving free school lunch.

Eligibility criteria:
inclusion criteria: * 4th grade students from elementary schools that meet the historical criteria for \>50% students receiving free school lunch. exclusion criteria: * not meet the inclusion criteria

Keywords: school-based intervention bathroom policy healthy bladder behaviors bladder health education
three-chamber bags retrospective study in spain

Conditions: Parenteral Nutrition; Blood Stream Infection

Summary: the primary study objective is to assess the rates of blood stream infection (bsi) from the use of three-chamber bags (e.g., smofkabiven®, kabiven®, others) compared to hospital compounded bags (hcbs) in patients requiring parenteral nutrition in spanish hospitals.

this is a retrospective observational database study of patients receiving parenteral nutrition (pn) for at least 3 consecutive days with hospital admission date between january 1, 2013, and december 31, 2015 (study period). the study will use an as treated approach, where patients will be followed from the index date (hospital admission day of the hospitalization during which pn is administered) up to patient discharge or death (observation period). the study will be conducted using an initial emr (electronic medical record) data retrieval process, followed by manual data retrieval (chart review) that will complement data obtained from emr. data collection for manual data retrieval will be conducted through an ecrf. the documentation of patient data will comprise two sequential steps. the initial step will include data of 30% of patients and then an interim analysis (ia) will be conducted. if ia shows positive results, data for the remaining 70% of patients (step ii) will be gathered. the study will be conducted in 10-14 sites in spain. data analysis: baseline demographics, co-morbidities, and hospitalization characteristics will be reported descriptively by means of mean with standard deviations and medians with ranges for continuous variables and by counts and percentages for categorical variables. incidence rates for bsi will be reported by treatment group.

Eligibility criteria:
inclusion criteria: 1. adult hospital inpatients ≥ 18 years 2. treatment with pn for at least 3 consecutive days 3. pn containing all three major macronutrients, delivered from 3cb or hcb 4. patients with hospital admission between january 1, 2013, and december 31, 2015 (study period) exclusion criteria: 1. bloodstream infection before or at the same day of first pn administration 2. immunosuppression due to concomitant therapy (e.g., immunosuppressive therapy due to transplantation, concomitant oral or intravenous administration of glucocorticoids) or disease (e.g., hiv, leukaemia) 3. permanent vascular access (port, shunts for dialysis) 4. femoral venous placement of central venous line used for pn 5. burns, extensive skin injuries (e.g., lyell´s disease) 6. chemo-/radiotherapy for up to 3 months before hospital admission 7. change of pn bag type during observation period, e.g., from hcbs to 3cbs or vice-versa

Keywords: parenteral nutrition icu 3-chamber bags icd-9-cm bsi medical records system computerized
sensorimotor training versus resistance training in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: people with knee osteoarthritis (oa) have functional instability and defective neuromuscular function, it was recently suggested that sensorimotor exercises may be important and needed to improve the effectiveness of training programs for these patients. this study objective was to compare the effectiveness of a supervised resistance muscular training (rt) versus sensorimotor training (smt) for patients with knee oa, on decrease of pain and functional improvement.


Eligibility criteria:
inclusion criteria: * patients diagnosed with tibiofemoral osteoarthritis; * both genders; * age\> 50 years \<75 years; * completion of clinical and radiological criteria of the american college of rheumatology (acr) criteria for knee oa; * no physical activity in the previous 3 months; * education level from the 4th grade of primary school. exclusion criteria: * uncontrolled hypertension; * decompensated diabetes mellitus; * uncontrolled thyroid diseases; * cardiorespiratory disease (ischemia, arrhythmia, chest pain, or exercise-induced bronchospasm), liver abnormalities; * patients with grade iv functional limitation that needed devices to walk(kellgren-lawrence radiographic classification); * patients in a period of sick leave by the inss or any other related factor; * other rheumatic diseases.

Keywords: knee osteoarthritis exercise therapy resistance training proprioception
the effectiveness of stellate ganglion block in managing dysphagia in patients with medullary infarction

Conditions: Bulbar Palsy

Summary: this is a randomized controlled study, including dysphagic patients with bulbar palsy after ischemic stroke who were received in the department of rehabilitation medicine. all patients are randomly allocated to the observation group or the control group. both groups are provided with comprehensive rehabilitation. besides, the observation group additionally undergoes the stellate ganglion block. at admission and after 10-day treatment, video fluoroscopic swallowing study, and penetration-aspiration scale, functional oral intake scale, flexible laryngoscope are used to assess swallowing function.

palliation of dysphagia in patients with bulbar palsy after ischemic stroke continues to be a challenge. this is a randomized controlled study, including dysphagic patients with bulbar palsy after ischemic stroke who were received in the department of rehabilitation medicine. all patients are randomly allocated to the observation group or the control group. both groups are provided with comprehensive rehabilitation. besides, the observation group additionally undergoes the stellate ganglion block. at admission and after 10-day treatment, video fluoroscopic swallowing study, and penetration-aspiration scale, functional oral intake scale, flexible laryngoscope are used to assess swallowing function.

Eligibility criteria:
inclusion criteria: * diagnosed with ischemic stroke according to the diagnostic criteria, with the stroke occurring in the medulla oblongata and diagnosed as bulbar palsy. * upper esophageal sphincter did not open or opened ineffectively, with food residue or aspiration, revealed by videofluoroscopic swallow study. * age \>18 years. * first-time stroke. * steady vital signs, * transferred or admitted to the department of rehabilitation medicine within 15d after onset. exclusion criteria: * the bulbar palsy caused by other diseases, such as neurodegenerative diseases. * pseudobulbar palsy. * complicated with other neurological diseases. * tracheostomy tube inserted. * simultaneously suffering from liver, kidney failure, tumors, or hematological diseases. * dysphagia caused by other possible diseases. * pregnant females.
preoperative versus postoperative ultrasound-guided rectus sheath block for sleep quality and cytokines of patients

Conditions: Postoperative Pain

Summary: rectus sheath block (rsb) is used for postoperative pain relief in patients undergoing abdominal surgery with a midline incision. it has proved to be effective in preoperative block, but it has not been previously compared with postoperative block. the aim of the present study is to evaluate postoperative pain, sleep quality and changes in the cytokine levels of patients undergoing gynaecological surgery with rsb performed preoperatively versus postoperatively.

rectus sheath block (rsb) is used for postoperative pain relief in patients undergoing abdominal surgery with a midline incision. it has proved to be effective in preoperative block, but it has not been previously compared with postoperative block. the aim of the present work is to evaluate the postoperative sleep quality and changes in cytokines of patients undergoing gynaecological operation with rsb preoperatively or postoperatively. methods/design this study is a prospective, randomized, controlled (randomized, parallel group, concealed allocation), double-blinded trial. all patients undergoing transabdominal gynaecological operation will be randomized 1:1 to the treatment intervention with general anaesthesia as an adjunct to rsb preoperatively or postoperatively. the objective of the trial is to evaluate the postoperative sleep quality and changes in cytokines of patients undergoing hysterectomy with rsb preoperatively (n=32) or postoperatively (n=32). all of the patients, irrespective of group allocation, will receive patient-controlled intravenous analgesia with oxycodone. the primary objective is to compare the interval between leaving the post-anaesthesia care unit and receiving the first pcia bolus injection on the first postoperative night between patients who receive preoperative versus postoperative rsb. the secondary objectives will be to compare (1) cumulative oxycodone consumption at 24 h after surgery; (2) postoperative sleep quality, as measured using a bis-vista monitor during the first night after surgery; and (3) cytokine levels (interleukin-1, interleukin-6, tumour necrosis factor-α and interferon-gamma) during surgery and at 24 and 48 h postoperatively.

Eligibility criteria:
the inclusion criteria are as follows: (1) an age of 18 to 65 years old; (2) scheduled to undergo elective midline incision transabdominal gynaecological surgery for benign mass; and (3) american society of anaesthesiologists (asa) risk classification i-ii. the exclusion criteria are as follows: (1) patient refusal; (2) known hypersensitivity to the study medication (ropivacaine); (3) long-term use of opioids; (4) liver or renal insufficiency; (5) a history of psychiatric or neurological disease; (6) deafness; (7) previous open surgery; (8) regular use of acetaminophen, nonsteroidal anti-inflammatory drugs, corticosteroids, or antiemetics; and (9) a preoperative pittsburgh sleep quality index (psqi) global score of higher than 6

Keywords: rectus sheath block cytokines sleep