Kornimate/medical-research-clean huggingface dataset:
short term outcome of laparoscopic trans-abdominal preperitoneal inguinal hernia repair without mesh fixation

Conditions: Inguinal Hernia

Summary: comparison between two groups of participants suffering inguinal hernia each group 23 individual all underwent laparoscopic trans-abdominal inguinal hernia repair first group received mesh fixation the second underwent no fixation , results of follow up in the first year were compared together

this comparative study was performed in zagazig university hospitals, general surgery department in the time period between july 2018 and june 2020 0n 46 patients undergoing laparoscopic trans abdominal preperitoneal (tapp) repair for un complicated unilateral inguinal hernia. patient selection; in this study we enrolled patients above * 18 years old suffering unilateral, * non -recurrent, * un-complicated inguinal hernia. we excluded patients with * previous abdominal or pelvic surgery, * unfit with laparoscopic surgery, * those with ascites, * abdominal malignancy * on chemotherapy and immune-compromised patients. randomization; using computer generated random numbers , the study participants were randomly allocated into two equal groups each group 23 individual, the first group; group a; patients underwent laparoscopic tapp repair of inguinal hernia and the mesh prosthesis was fixed in position using absorbable vicryl tacks (abstack30 medtronic), and group b patient underwent laparoscopic tapp repair of inguinal hernia and the mesh prosthesis was placed in position without fixation. all the study participants were subjected to thorough history taking, detailed clinical examination, determination of the presence of inguinal hernia, measurement of the hernia defect diameter by ultrasound or computerized tomography in difficult cases, preoperative laboratory tests were performed as per usual follow up early postoperative data during the admission were collected, a; pain score (measured by visual analogue scale (vas), hematoma formation, early recurrence, time needed for ambulation. follow up was carried out in outpatients clinics by the attending surgeon after 1 week, 1 month,3 months and 6 months of the operation , the recorded follow up data included wound complications, seroma formation, foreign body sensation and recurrence. the study was approved by the local ethical committee and institutional review board (irb) of our university hospitals, all patients signed an informed written consent before participation in this study preoperative, demographic, operative and postoperative data were collected and properly analyzed using t test, z test in spss 22 program package

Eligibility criteria:
inclusion criteria: * 18 years old suffering unilateral, * non -recurrent, * un-complicated inguinal hernia. exclusion criteria: * previous abdominal or pelvic surgery, * unfit with laparoscopic surgery, * those with ascites, * abdominal malignancy * on chemotherapy and immune-compromised patients.
comparative effectiveness and safety of inhaled corticosteroids and antimicrobial compounds for non-cf bronchiectasis

Conditions: Bronchiectasis

Summary: the purpose of this study is to provide patients and their physicians with greater understanding of the risks and benefits of commonly used therapies for treatment of non-cf bronchiectasis

non-cf bronchiectasis is a chronic inflammatory lung disease that is closely linked to pulmonary ntm disease. both are rare but rising in incidence and disproportionately affect the elderly and women. therapy of non-cf bronchiectasis aims to reduce inflammation via either ics-induced immunosuppression or antibiotic-associated immunomodulation and/or suppression of pathogenic organisms. both strategies, pursued long-term alone or some cases concomitantly, have inherent risks, and the relative risks and benefits of these differential approaches are poorly studied to date. ultimately, our study will provide patients and their physicians with greater understanding of the risks and benefits of these therapeutic choices.

Eligibility criteria:
inclusion criteria: * within medicare data, indicated diagnosis of bronchiectasis by a pulmonologist (icd-9 code 494.0 and/or 494.1) exclusion criteria: * cystic fibrosis diagnosis, hiv infection, history of organ transplant

Keywords: nontuberculous mycobacteria corticosteroids macrolides antibiotics
urethral stricture database

Conditions: Urethral Stricture

Summary: establishment of a clinical urethral stricture database for a prospective longitudinal cohort study.

the aim is to establish a prospective clinical database of patients undergoing urethral surgery due to urethral stricture. in addition to pre-operative basic data, intraoperative and postoperative data, as well as follow-up data through questionnaires, are to be collected. the main objective is the prospective determination of success rates of the performed urethral surgeries in the short, medium, and long term. furthermore, risk factors leading to failure (recurrence of urethral stricture) should be identified. ultimately, the quality of life before and after urethral surgery is to be assessed in order to compare the applied procedures. in today's reconstructive urethral surgery, there are few scientific surveys so far. many of the applied techniques (therapy options) are based more on the experiences of individual surgeons than on a solid database, hence there are also different approaches. by evaluating prospective data and comparing individually applied surgical methods, the least complication-prone and most successful techniques are to be identified. the planned study aims to create an "efficacy-safety" profile for each urethral surgery technique. this will enable us in the future to not only provide improved (data-based) patient information but also to involve the patient better in the therapy decision. thus, in the future, counseling and therapy for a young sexually active patient could differ from counseling for an older patient who is no longer sexually active, even with the same stricture length and location. the analyses of the urethral database will thus enable us to internally validate therapy algorithms and provide personalized patient counseling.

Eligibility criteria:
inclusion criteria: all patients undergoing any of the following urethral surgeries are included: * internal urethrotomy according to sachse (endoscopic transurethral urethrotomy) * end-to-end anastomosis * urethral plastic surgeries with oral mucosa graft (potentially penile skin) * urethral plastic surgeries with mesh graft * hypospadias corrections * boutonniere * (self) bougienage of the urethra exclusion criteria: * lack of capacity to consent

Keywords: reconstructive surgery quality of life perioperative outcomes
efficacy and safety of voclosporin to treat active noninfectious uveitis

Conditions: Noninfectious Uveitis

Summary: the primary objective of this study is to assess the safety and efficacy of voclosporin as therapy in subjects with active noninfectious uveitis involving the intermediate and/or posterior segments of the eye (i.e., anterior + intermediate-, intermediate-, posterior- or pan-uveitis).


Eligibility criteria:
inclusion criteria: * active noninfectious uveitis involving the intermediate and/or posterior segment (i.e., anterior + intermediate-, intermediate-, posterior- or pan-uveitis) in at least one eye as evidenced by a vitreous haze grade of at least 2+ at the baseline visit. subjects who also have anterior segment involvement need not be excluded if otherwise qualified. * subjects must be: * capable of understanding the purpose and risks of the study. * able to give written informed consent. * able to comply with all study requirements. exclusion criteria: * ocular disease/conditions * the following conditions are exclusionary if present: * uveitis limited to only the anterior segment of the study eye. * confirmed or suspected infectious uveitis in either eye. * prior and current treatment: - as defined in the protocol * extraocular conditions: - as defined in the protocol. * laboratory, blood pressure and ecg evaluations: * as defined in the protocol.
collection of pleural effusion fluid

Conditions: Solid Tumor; Pleural Effusion; Metastasis

Summary: at the laboratory for molecular and cellular therapy (lmct) of the vrije universiteit brussel, belgium, we study resistance mechanisms that hamper effective immunotherapy for solid cancer patients. to perform clinically relevant research, we apply autologous human material for functional assessment. the latter requires viable tumor and immune cells. solid cancer patients with pleural metastasis often develop pleural effusion. notably, upon pleural drainage, residual material is obtained that consists of histocompatible tumor and immune cells. hence with this study, we want to obtain blood and pleural effusion fluid drawn from solid cancer patients with pleural metastases to: 1. collect, enrich and store primary cells derived from residual pleural effusion fluid and blood at the lmct (vub, belgium) 2. evaluate characteristics of the cells (phenotype, function,...) and compare content of pleural effusate with blood and clinicopathologic features of the patients.

malignant pleural effusion (mpe) is characterized by the presence of malignant cells in the pleural cavity and develops in about 15% of patients with malignant disease. two-thirds of all cases have a pleural effusion as one or sole initial manifestation of malignant disease. primary tumors that most frequently develop mpe as metastatic disease are lung, breast cancer, and lymphoma accounting for 75% of all cases. discomforting symptoms of mpe can include chest pain, cough, wheezing, hemoptysis, general discomfort, uneasiness, or ill feeling (malaise), shortness of breath and weight loss. to relief these discomforting symptoms, pleural drainage (evacuation) is routinely performed. a significant number of solid cancer patients are currently being treated with immunotherapeutic drugs in first or second line or in the framework of a clinical trial. aside from tumor cell intrinsic mechanisms, we and others previously found that non-malignant tumor infiltrated cells can also install immunotherapy resistance. hence it remains of utmost importance to study the functional interactions between tumor cells and their non-malignant (solid) micro-environment to increase our current understanding of molecular profiles that predict responsiveness to immunotherapy. by exploiting patient-derived material, we aspire to perform more clinically relevant fundamental and translation research. the primary objective is to collect and compare blood, tumor and mpe-derived cell fractions. the secondary objective is to correlate cellular profiles with clinico-pathologic data.

Eligibility criteria:
inclusion criteria: * all solid cancer patients with pleural metastases undergoing pleural drainage with available tumor biopsy (upon informed consent) * \>18 years of age exclusion criteria: * pregnancy healthy volunteers will be included for collection of control blood samples (upon informed consent).
comparison of the effectiveness of spair-q among different age groups

Conditions: Postoperative Complications; Sore-throat; Airway Complication of Anesthesia

Summary: some previous studies have reported structural and physiological changes in the pharyngeal airway and ues with aging . it has been found that the shape and size of the pharyngeal airway in elderly individuals differ from those of young adults. this study aims to compare the effectiveness of the air-q laryngeal mask airway (lma) across different age groups (young, middle-aged, and elderly patients) and to evaluate complications associated with supraglottic airways (sga).

"supraglottic airway devices (sga) used perioperatively are known to require lower anesthetic depth and result in fewer airway complications such as coughing and sore throat after awakening from anesthesia compared to endotracheal intubation. due to these advantages, sgas are particularly beneficial in elderly patients, as they experience a reduction in functional reserves, are more affected by cardiopulmonary diseases, and are more sensitive to anesthetic drugs sgas are inserted through the oral route, and the sga cuff is placed between the base of the tongue, hypopharynx, and upper esophageal sphincter (ues) to provide proper ventilation. some previous studies have reported structural and physiological changes in the pharyngeal airway and ues with aging . it has been found that the shape and size of the pharyngeal airway in elderly individuals differ from those of young adults. additionally, there are changes in the function and structure of the ues with age. these age-related changes may affect the performance of sgas in the elderly population. recently, sgas that do not require manual cuff inflation have been used more frequently in various clinical settings due to the advantages of eliminating the need for manual cuff inflation and cuff pressure monitoring. the air-q is connected to an airway tube through a communication port that allows for self-regulation of cuff pressure in response to airway pressure."

Eligibility criteria:
inclusion criteria: * 18-85 year-old patients * american society of anesthesiologist physical status classification i-iii, * undergoing an elective operation under general anesthesia in our hospital exclusion criteria: * predicted difficult airway (mallampati class 4, mouth opening \< 3 cm, or thyromental distance \< 6 cm) * body mass index (bmi) \> 40 kg/m2 * patients with a high risk of aspiration (e.g., history of gastrectomy, gastroesophageal reflux disease, or hiatal hernia), * unstable vital signs, * cervical spine problems, respiratory complications (e.g. recent pneumonia).

Keywords: air-q laryngeal i̇ntubating airway oropharyngeal leak pressure supraglottic airways
the effectiveness of purposeful exercises in children diagnosed with special learning disabilities

Conditions: Lack of; Attention, With Hyperactivity (ADHD); Specific Learning Disability

Summary: the aim of the study is to examine the effect of purposeful balance and coordination exercises on attention and quality of life in children diagnosed with special learning disabilities.

the study was planned as a randomized controlled trial, and children aged 7-17 who were diagnosed with "special learning disability" in a special education center in kocaeli-darica were included as a sample. children were divided into experimental and control groups by randomization. in addition to the individual training program they received from the special training center, the experimental group was given goal-oriented balance and coordination exercises for 8 weeks, 2 days a week for 40 minutes. the control group continued only the individual training program. all participants and their parents were informed about the study, and an informed consent form was obtained from the participants and their parents. in order to collect data from the participants; "leisure time activity questionnaire for children" to determine physical activity levels, "quality of life assessment questionnaire for children" to determine their quality of life, "bruininks-oseretsky motor proficiency test 2 short form" to evaluate motor skills, "burdon attention test" to measure attention level used. these tests and forms were repeated before starting the study and at the end of the study. pre- and post-intervention data were statistically analyzed and compared.

Eligibility criteria:
inclusion criteria: * being diagnosed with special learning disabilities * to be between the ages of 7-15 * to attend the special education and rehabilitation center and individual support training program regularly. * not having exercise intolerance or any disease that prevents exercise * the child's willingness to participate in the study and the consent of the parent to participate in the study exclusion criteria: * having physical or psychological disorders in addition to the diagnosis of special learning disabilities (adhd, etc.) * being diagnosed with special learning disabilities and not complying with the age range * not attending the individual training program regularly * parents not giving consent for the child to participate in the study
how often and what type of deformity is detected in all spine radiographs?

Conditions: Scoliosis; Kyphosis; Radiography

Summary: the study will be done retrospectively.the aim of this study is to retrospectively examine the spinal pathologies of patients with a prediagnosis of spinal deformity and for whom spinal radiography is requested and to evaluate the clinical features of these patients.

spinal radiography for scoliosis is the gold standard in the diagnosis, treatment and follow-up of spinal diseases. there are studies showing that unnecessary and repetitive radiographs of patients increase the risk of cancer in older ages. patients should be thoroughly examined before a spine radiograph is taken. adam's test should be applied to the patient with scoliosis findings in the physical examination. spinal radiography for scoliosis should be requested from those whose trunk rotation angle is 5 degrees or more during adam's test. the diagnosis of scoliosis is made when the cobb angle measured on posterior-anterior radiographs is greater than 10 degrees. the diagnosis of kyphosis is made when the cobb angle measured on lateral radiographs is greater than 50 degrees. patients with a prediagnosis of spinal deformity and spinal radiographs taken between january 2019 and september 2019 in the radiology clinic of our hospital will be included in the study. demographic characteristics of the patients, presence and degree of scoliosis on posterior-anterior radiographs, if present, degree of kyphosis on lateral radiographs, structural pathologies in the spine and clinical features will be investigated.

Eligibility criteria:
inclusion criteria: 1. patients aged 18 and under 2. those who requested spine radiographs for scoliosis and kyphosis exclusion criteria: 1. having a history of previous spinal surgery or trauma 2. repeated radiographs in the same patient

Keywords: scoliosis,kyphosis,radiography
preliminary data for breath biofeedback of dietary compliance

Conditions: Obesity

Summary: the investigators ultimate goal is to test the hypothesis that immediate feedback of dietary adherence will enhance compliance to a weight loss program. this study deals directly with gathering the needed preliminary data for a grant submission.


Eligibility criteria:
inclusion criteria: * healthy males or females age 18 or older exclusion criteria: * chronic disease

Keywords: obesity
a study of retreatment with mabthera (rituximab) in combination with methotrexate in patients with rheumatoid arthritis (ra)

Conditions: Rheumatoid Arthritis

Summary: this study will evaluate the efficacy and safety of various treatment and retreatment regimens of mabthera. all patients will receive concomitant methotrexate, 10-25mg once weekly either orally or parenterally. the anticipated time on study treatment is 2+ years, and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * adult patients \>=18 years of age; * ra for \>=6 months; * receiving outpatient treatment; * inadequate response to methotrexate, having received and tolerated it for \>=12 weeks, with a stable dose for \>=4 weeks. exclusion criteria: * rheumatic autoimmune disease other than ra, or significant systemic involvement secondary to ra; * inflammatory joint disease other than ra, or other systemic autoimmune disorder; * diagnosis of juvenile arthritis, or ra before the age of 16; * previous treatment with \>1 biologic agent, any cell-depleting therapies, or concurrent treatment with any biologic agent or dmard other than methotrexate.
interpersonal and social rhythm therapy enter the brief title for protocol irb 09-003781>

Conditions: Bipolar Disorder, Depressed

Summary: in patients with bipolar disorder referred for psychotherapy, is interpersonal and social rhythm therapy delivered in a group psychotherapy format over 2-3 weeks feasible? this project will help determine if interpersonal social rhythm therapy can be delivered in the programmatic format being considered for the outpatient mood program.


Eligibility criteria:
adult patients with a confirmed diagnosis of bipolar disorder in a depressed phase. referral for interpersonal and social rhythm therapy

Keywords: bipolar depressed
a study assessing the safety, efficacy, and optimum dosage of k-161 in subjects with moderate to severe dry eye disease

Conditions: Dry Eye Disease

Summary: the objective of the study is to assess the safety, efficacy, optimum dosage, and dosing regimen of k-161 in adult subjects with moderate to severe dry eye disease.


Eligibility criteria:
inclusion criteria: * be at least 18 years of age at the time of informed consent visit. * have a reported history of dry eye disease in both eyes and a history of eye drop use for dry eye symptoms. * meet all inclusion criteria outlined in the clinical study protocol. exclusion criteria: * have any clinically significant ocular condition. * have a history of corneal refractive surgery and/or any other ocular surgical procedure within 12 months. * must not meet any other exclusion criteria outlined in the clinical study protocol.
biodiversity interventions for assisted living centers

Conditions: Nature, Human; Microbial Colonization; Well-Being, Psychological; Immune System and Related Disorders; Autism Spectrum Disorder; Visual Impairment

Summary: biodiversity is essential for nature and human well-being. land use has reduced biodiversity in cities, which weakens the functionality of the urban ecosystems and the well-being of citizens. this may also increase the risk of immune-mediated disorders among urban dwellers. in biodiversity interventions for assisted living centers (biwe 2), microbial biodiversity interventions are performed to increase biodiversity in urban housing units for people with autism spectrum disorder, disabled people and elderly. results from the intervention trials are combined with publicly available land cover and ecological data. these are analyzed from the viewpoint of shifts in ecosystems and human well-being and immune regulation, ecological quality, and urban planning. the investigators set up an intervention study in which yards of the housing units are rewilded with diverse vegetation and decaying deadwood and plant residuals. the investigators aim to evaluate the effect of rewilding, and yard management practices on commensal microbiome, cortisol levels and well-being and salivary cytokine levels, and gene pathways.

our specific aims are: to assess if rewilding diversifies health-associated skin microbiota and is associated with salivary cytokine levels, gene pathways, cortisol levels and commensal microbiota. assess whether there are patterns in the microbiome associated with the salivary cytokine levels and hair cortisol levels. assess whether rewilding affects health and psychological measures. the investigators will recruit approximately 36 study subjects living in assisted housing units in urban areas and aged between 18-82.

Eligibility criteria:
inclusion criteria: * person lives in assisted living center exclusion criteria: * immunosuppressive medications * immune deficiencies * a disease affecting immune response (colitis ulcerosa, rheumatoid arthritis, crohn's disease, diabetes) * cancer diagnosis within the last year or on-going cancer treatment

Keywords: biodiversity well-being planetary health commensal microbiome immune system