Kornimate/medical-research-clean huggingface dataset:
the effect of an education module to reduce weight bias among healthcare professionals in a private hospital setting

Conditions: Obese, Stigma

Summary: although scientific bodies have recognized obesity as a disease, obese people are often stigmatized, facing discrimination, and accusations that they are responsible to their condition due to their lack of willpower by healthcare professionals. however, experimental research to reduce weight bias among healthcare professionals is lacking, and published studies to date are methodologically flawed, including lack of randomization, lack of control group and small sample size. the study is designed to evaluate the effect of a comprehensive online education module on knowledge about obesity and weight bias in a convenience sample in a private hospital setting. this is an interventional study conducted among all assuta medical centers healthcare employees including physicians, bariatric surgeons, nurses, dietitians, social workers, physiotherapists, pharmacists, imaging department technicians, laboratory workers, patient services assistants and medical secretariats. participants who will confirm their consent to participate in the study, will be randomized into two arms: intervention vs. control (with no intervention). the study intervention will include an online 15-minute educational module which will be based on relevant literature and expert opinion and will include four sections: a) knowledge about obesity; b) weight bias definition and impact; c) strategies to reduce weight bias; d) a short quiz. at baseline, one week and one-month post intervention, both groups will respond to an anonymous on-line survey on knowledge about obesity and weight stigma. moreover, data on demographic parameters of study participants will be collected.


Eligibility criteria:
inclusion criteria: * all assuta medical centers healthcare employees will be recruited to the study exclusion criteria: -
pilot study on the effect of intrathecal opioids on immune function in humans with cancer pain

Conditions: Cancer-associated Pain

Summary: the purpose of this study is to examine the changes in immune function, as measured by biomarkers in the blood, that happen with intrathecal (spinal) delivery of opioid medications for the treatment of moderate to severe cancer pain. hypothesis: treatment of pain with intrathecal (spinal) therapy is associated with little alteration of immune function as measured by biomarkers in the blood of cancer patients with moderate to severe pain.

biomarkers of immune function will be measured before and after patients receive an intrathecal pain pump for management of cancer pain.

Eligibility criteria:
inclusion criteria: * diagnosis of cancer * evaluation by a pain management physician and confirmation that cancer is the primary etiology of patient's pain * moderate to severe pain, as specified by a baseline pain rating score of 5 or above on a scale from 0 (no pain) to 10 (worst pain imaginable) despite current opioid therapy * pain management plan (as developed by interventional pain service, patient and primary service) that includes placement of an intrathecal drug delivery system for pain management * able and willing to give informed consent exclusion criteria: * patients with an expected life expectancy of less than 12 weeks * patients not felt be a safe surgical candidate by pain management physician for placement of and intrathecal drug delivery system (idds) due to the presence of severe medical comorbidities * patients who are not a candidate for intrathecal drug therapy due to coagulopathy, concurrent necessary use of blood thinners, presence of systemic infection, drug allergy to analgesic agent, evidence of csf obstruction or other technical factor * severe or untreated psychiatric disease * refusal of informed consent * pregnant patients or patients less than 18 years of age

Keywords: cancer-associated pain immune function
vitiligo skin transplantation

Conditions: Vitiligo

Summary: in vitiligo, the melanocytes are lost from the skin in certain areas. one treatment for vitiligo takes the melanocytes from areas of normal skin and places them on areas of that same person's body which have lost their color. this is called the melanocyte-keratinocyte transplantation procedure (mktp). this procedure has been used successfully in over 3000 cases in india and saudi arabia. the purpose of this study is to see if it is effective when performed at the investigators' institution.


Eligibility criteria:
inclusion criteria: 1. be at least 18 years old 2. have a diagnosis of vitiligo with no news lesions or growth of old lesions in the past 6 months 3. be able to understand the requirements of the study, the risks involved, and be able to sign the informed consent form 4. agree to follow and undergo all study-related procedures exclusion criteria: 1. female patients who are breastfeeding, pregnant, or planning to become pregnant 2. patients with a history of developing vitiligo or keloids at sites of trauma 3. patients self-reported as having hiv or hepatitis c 4. patients self-reported as having uncontrolled diabetes mellitus 5. the investigator feels the patient should not participate in the study for any reason

Keywords: vitiligo skin transplantation non-cultured melanocyte surgery
effectiveness of social skills training group for children with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: socio-communicative impairments are core deficits in individuals with autism spectrum disorder (asd). individuals with asd have difficulty understanding eye contact, facial expressions, body language, and different tones of voice when communicating with others. they can't interpret the thoughts and feelings of others, or predict social events, and the impaired social skills may lead to rejection of peers and poor participation in school. social skills training targets the core symptoms of asd. empirical support is building for cognitive-behavioral intervention approach, social skills training group for verbally fluent, school-aged children with asd. several studies have shown the efficacy of the social story intervention. it is usually provided individually, but we want to use it in the group.

many different intervention program have been used throughout the world. one alternative method used to teach children is the social stories method, which was created by gray (1993) to address the social difficulties of children with asd. the theoretical framework of the social stories is based on theory of mind (tom) hypothesis. difficulties associated with the impaired tom was addressed by explaining the complex social concepts in simple words and often include the description of perspectives of others. several studies have shown the efficacy of the social story intervention. it is usually provided individually, but we want to use it in the group. in this study, we plan to randomly assign thirty-six 5-7-year-old children with asd to one of two kinds of social skills groups: the social skills group or the play activities group (control condition). group met for 16 weeks, one time per week, one hour each time. participants were recruited between october 2020 and september 2023. assessment were conducted at baseline and endpoint (16 weeks). to empower parents, we would also ask parents of participants to attend our treatment and lecture.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of autism spectrum disorder * must be able to understand 3-steps verbal commands exclusion criteria: * mental retardation * seizure

Keywords: autism,autism spectrum disorder,social skill training
loop resection or cold-cup biopsy? a study comparing the accuracy of muscle samples during bladder tumor surgery

Conditions: Bladder Cancer; Bladder Cancer Stage I; TURBT

Summary: in this report the investigators compared two deep muscle sampling methods (loop resection and cold-cup biopsy) during endoscopic resection of bladder tumors for patients with suspected bladder cancer in tygerberg hospital. the investigators found that both sampling methods are equal effective with regards to muscle representation, regardless of surgeon experience. an important finding is that loop resection produced less tissue artefacts in the deep muscle specimen for the more experienced surgeons, while there was no difference for less experienced surgeons. the investigators thus conclude that - from a practical point of view - loop resection should be the deep muscle sampling method of choice.


Eligibility criteria:
inclusion criteria: * • all patients requiring cystoscopy plus loop resection of bladder tumor. exclusion criteria: * • patients who underwent cystoscopy and no loop resection * patients who underwent cystoscopy and only cold-cup biopsy

Keywords: bladder cancer detrusor muscle sampling detrusor muscle representation loop resection cold-cup biopsy artifacts
the dietary education trial in carbohydrate counting (diet-carb study in type 1 diabetes

Conditions: Type1diabetes; Type1 Diabetes Mellitus; Glucose Metabolism Disorders

Summary: the study is designed to evaluate two different dietitian-led self-management approaches in carbohydrate counting compared to routine dietary care (control) on glycaemic control in adult patients with type 1 diabetes: 1. the basic carbohydrate counting concept aims at improving carbohydrate counting accuracy and day-to-day consistency of carbohydrate intake (the bcc intervention) 2. the advanced carbohydrate counting concept aims at improving prandial insulin dose accuracy using an automated bolus calculator (the abc-acc intervention) the main hypothesis is that structured training and education in either the bcc concept or the abc-acc concept will reduce hba1c or the average glucose variability more than routine dietary education.

the current study is a randomized controlled trial with a parallel-group design. a total of 231 patients will be enrolled in the trial. participants will be randomized to one of three arms: 1) basic carbohydrate counting (bcc), 2) advanced carbohydrate counting with an automated bolus calculator (abc-acc), or 3) standard dietary care. the primary objective is to evaluate the six months effects of education in the bcc concept and the abc-acc concept compared to standard dietary care on glycaemic control as assessed by hba1c or mage (mean amplitude of glycaemic excursions).

Eligibility criteria:
inclusion criteria: * type 1 diabetes * diabetes duration; \>12 months * hba1c of 53-97 mmol/mol * multiple daily insulin injection therapy * provided voluntary written informed consent exclusion criteria: * practicing carbohydrate counting, as judged by the investigator * participated in a bcc group program within the last two years * use of insulin pump, or plans of having an insulin pump within the study period * fixed dose of rapid acting insulin therapy for meals * split-mixed insulin therapy * use of open cgm * use of freestyle libre * use of an automated bolus calculator * gastroparesis * pregnancy or breastfeeding, or plans of pregnancy within the study period * low daily intake of carbohydrates (defined as below 25 e% or 100 g/day), as judged by the investigator * uncontrolled medical issues, as judged by the investigator or a medical expert * concomitant participation in other clinical studies * unable to understand the informed consent and the study procedures

Keywords: carbohydrate counting basic carbohydrate counting advanced carbohydrate counting carbohydrates diet
autoimmunity after checkpoint blockade

Conditions: Autoimmunity; Cancer; Immunotoxicity; Oncology

Summary: the purpose of this study is to better understand how the treatment of cancer with immune checkpoint inhibitors (ici) leads to the development of autoimmunity. specifically, we wish to understand the genetics and immune system features that cause a subset of cancer patients treated with checkpoint inhibitor therapy to develop an immune-related adverse event (irae).

the goal of this study is to understand how the treatment of cancer with checkpoint inhibitors leads to the development of autoimmunity. specifically, to understand the genetics and immune system features that cause a subset of cancer patients treated with checkpoint inhibitors to develop autoimmunity. at least 300 patients will be enrolled when they are initially prescribed any checkpoint inhibitor. peripheral blood and serum from patients when they enroll and examine the genetics, serum factors, and phenotype of the immune system. there is no planned intervention. subjects will be asked to provide peripheral blood and serum at established time points when they are getting therapeutic infusions and routine clinical labs, as well as, at the time they develop any autoimmune symptoms. urine may also be collected at the time of enrollment, standard study visits, and/or at the time of an autoimmune complication. inclusion criteria include a diagnosis of cancer, prescription for a checkpoint inhibitor, and fluency in english. exclusion criteria include any subjects not willing or able to give consent, children under the age of 18, and history of transplant. there will not be any interventions. clinical data will be extracted from electronic medical records. coded data will be stored in a redcap database. phi and study key stored at upenn on a password-protected database on an encrypted drive that is institutionally secured and managed by the university of pennsylvania.

Eligibility criteria:
inclusion criteria: * a diagnosis of cancer and prescription for a checkpoint inhibitor exclusion criteria: * any subjects not willing or able to give consent * children under the age of 18 * a history of transplant
interactive rehabilitation for adults with unilateral vestibular weakness

Conditions: Dizziness; Equilibrium; Disorder, Labyrinth; Inner Ear Injury

Summary: people that have difficulty with balance, such as those with damage to their inner ear, have a higher risk of falling, which may lead to anxiety and reduced quality of life. some individuals that have lost part of their sense of balance can learn to compensate using information from their vision, their sense of where their limbs are in space, and from other balance organs that are still intact. our study aims to determine if virtual reality used together with information from footplate sensors can be used to train people with balance problems to compensate for their inner ear deficits.


Eligibility criteria:
inclusion criteria: * adult age 18-80 * unilateral vestibular weakness confirmed one or more of: * videonystagmography * vemp * or unilateral vestibular weakness idiopathic, not yet diagnosed (nyd) * persistent imbalance following diagnosis of resolved benign paroxysmal positional vertigo (bppv) * symptomatic * long-standing/persistent symptoms greater than one year exclusion criteria: * orthopedic deficit (eg. lower body joint dysfunction or lower joint replacement) * neurological deficit or proprioception deficit * diabetes * poor vision or blindness * fluctuating vestibular symptoms, or condition known to fluctuate eg. menière's disease, perilymphatic fistula (plf) or superior canal deshicsence (sdcs) * active benign paroxysmal positional vertigo (bppv) * undergoing treatment which may affect balance or ability to stand * cognitive impairment that prevents understanding and responding to instructions required to complete the study * inability to provide informed consent
physical therapy on non-structural medial elbow pain

Conditions: Elbow Injuries and Disorders; Neuritis, Ulnar; Neuritis, Brachial; Neuritis; Nerve Root; Neuritis Median Nerve

Summary: this study is investigating the effect of using a regional interdependence approach of managing non-structural elbow pain with physical therapy.

potential patients will be referred for physical therapy with elbow nerve pain arising from a non-structural lesion. we believe by addressing spine and trunk posture and mobility we can relieve elbow pain associated with a nerve compression with physical therapy. patients will be put on a staged exercise program to regain spinal mobility and strengthen proximal core musculature and scapular musculature. manual therapy to facilitate mobility will be incorporated. patients will undergo standard physical therapy by an unblinded therapist until resolution of symptoms.

Eligibility criteria:
inclusion criteria: * the patient presents with elbow pain that is not exacerbated with resisted wrist flexion, extension, supination, or pronation. * the patient presents with elbow pain that is not exacerbated with passive wrist flexion or extension. * the patient presents with three of the four positive cervical radicular signs * patient presents with peripheral paresthesia exclusion criteria: * the patient reports a surgical history involving the elbow. * the patient has an mri that is positive for structural deficits within the upper extremity. * the patient self-reports a diagnosis of rheumatoid arthritis or other neurological systemic diseases such as parkinson's disease, cerebrovascular accident, multiple sclerosis, or similar conditions

Keywords: regional interdependence posture neural tension physical therapy
ketoprofen gel vs placebo in children with ankle sprain

Conditions: Ankle Sprain

Summary: the aim of this study is to analyse the effect of ketoprofen gel in children presented with ankle sprain to the emergency department.

ankle sprains may be associated with soft tissue injuries and fractures. although diagnostic modalities are important, alleviation of pain is also a part of emergency department management. the aim of this study is to analyse the effect of ketoprofen gel in children presented with ankle sprain to the emergency department.

Eligibility criteria:
inclusion criteria: * patients with ankle sprain * patients over 8 and lower than 18 years old exclusion criteria: * ankle sprain more than 24 hours * visual analogue scale score lower than 40mm * allergy to the study drug
restoring hand function in patients with tetraplegia by intraneural stimulation of peripheral nerves

Conditions: Tetraplegics

Summary: the aim of the clinical investigation is to evaluate the feasibility, in terms of efficacy and safety, of a prosthetic system, the regrasp 1 system, based on intraneural stimulation via time- 4h electrodes, as an aid device for restoring hand function in tetraplegic patients.

the study involves implanting intraneural electrodes in the nerve used to open and close the hand. electrical stimulation will activate the forearm and hand muscles, and thus evoke movements such as opening and closing the fingers of the hand and wrist movements. electrodes will be implanted temporarily and reversibly within the fascicles so that a more selective and therefore more effective stimulation can be determined. the electrodes will remain implanted for about 6 months. during this period, the results of the external electrical stimulation will be analysed through experimental sessions that will take place at the careggi university hospital. at the end of the study, the electrodes will be removed by surgery under general anaesthesia.

Eligibility criteria:
inclusion criteria: 1. men or women aged between 18 and 70. 2. spinal cord injury at the c5-6 level, with complete motor paralysis (asia a or asia b). 3. chronic injury (\&gt; 6 months), with stable clinical condition. exclusion criteria: 1. systemic infections. 2. central and/or peripheral nervous system comorbidity. 3. reduced joint flexibility. 4. severe spasticity of the upper limb (mas 3). 5. severe denervation of forearm and hand muscles (as demonstrated by electromyography and electroneurography analysis and intraoperative neural stimulation). 6. muscles not electrically excitable. 7. presence of hyperalgesia or allodynia. 8. wearers of life support devices that could be adversely affected by electromagnetic interference, such as pacemakers, implanted cardioverter defibrillators, etc. 9. cognitive impairment. 10. active or history of psychiatric illnesses including major depression, bipolar disorder and personality disorders (borderline or antisocial personality disorder). 11. pregnancy. 12. history of alcohol or substance abuse. 13. acquired brain injury with residual deficits. 14. participation in other clinical trials. 15. known allergies/hypersensitivity to time-4h electrode materials. 16. life expectancy of less than one year. 17. contraindications to general anaesthesia (patient refusal, severe aortic stenosis, significant pulmonary disease, etc.).

Keywords: electrodes intraneural stimulation hand tetraplegia
exercises using virtual reality on cancer patients

Conditions: Breast Cancer Female

Summary: in this study, a randomized controlled trial will be conducted to evaluate the effect of adding exercises using virtual reality on achievements in patients having breast cancer and conducted surgical treatment

in this study, a randomized controlled trial will be conducted to evaluate the effect of adding exercises using virtual reality on achievements in patients having breast cancer and conducted surgical treatment. a virtual reality (vr) environment is created by combining computer systems and sensor technology with the use of three-dimensional graphics and enabling users to experience a more real, immersive experience by utilizing their various senses (vision, hearing, touch, etc.) through the use of the computer and sensor technologies and it is characterized by immersion, imagination, and interaction 2 groups will be selected randomly to receive experimental and control intervention for 1 month and outcomes will be collected before and after treatment.

Eligibility criteria:
inclusion criteria: * breast cancer female patients * age ≥40 years * all patients with eastern cooperative oncology group performance status score ≤ 2 * having to undergo primary treatment with surgery, chemotherapy, and/or radiotherapy based on the patient's need exclusion criteria: * severe anemia (hb ≤ 8 g/dl) * uncontrolled hypertension, diabetes * severe infection, neurologic or muscular diseases prohibiting physical activity * severe heart disease or myocardial infarction during the last six months, and a severe chronic obstructive pulmonary disease * uncontrolled and/or extensive brain metastases, or bone metastases that were assessed to pose a risk of pathological fractures from exercising * contraindications given by the physician
impact of expressive touching during embryo transfer

Conditions: IVF-ET

Summary: infertile individuals report psychiatric symptoms and that their levels of anxiety and depression are significantly higher than in fertile controls .thus,this study aimed to determine the effect of expressive touching during embryo transfer on the anxiety and pregnancy rate.


Eligibility criteria:
inclusion criteria: * having a diagnosis of primary infertility, * being over the age of 25 and under the age of 35 * able to read and write arabic, * women who will be applied assisted reproductive techniques such as ivf- icsi-et, * women with the same drugs and protocols used in ivf treatment was included in the study. exclusion criteria: * women who have problems in understanding and perception, * having a diagnosis of secondary infertility wasn\&#39;t included in the study

Keywords: embryo expressive touching women pregnancy anxiety in vitro fertilization