Kornimate/medical-research-clean huggingface dataset:
telerehabilitation program bases aerobic and baduanjin exercises in post stroke elderly patients

Conditions: Stroke

Summary: it is an interventional study in which 60 stroke patients estimated to enroll according to random allocation and will divided into two groups. the study group participants will involve in telerehabilitation sessions will be based on low-impact rhythmic movements, guided by video with the baduanjin exercise program ,the control group will receive the same aerobic exercises only

it is an interventional study in which 60 stroke patients estimated to enroll according to random allocation and will divided into two groups. the study group participants will involve in telerehabilitation sessions will be based on low-impact rhythmic movements, guided by video, according to the protocol of (schachter et al., 2003). the telerehabilitation program will be moderately intense aerobic exercise 3 times per week and will be included 3 parts: warm-up, central part, and cool-down. each session : 30 min, 3 sessions/ week for 3 months. the repetition rate will determine the intensity of the exercises: 10, 15, 20, or 25 repetitions per minute. the exercise intensity of each telerehabilitation session will be individually adjusted by the participants' modified borg perceived exertion. with the baduanjin exercise program is delivered individually, at each patient's home, through telerehabilitation, with direct remote supervision by a physiotherapist. each session consists of a short preparatory phase (stretching exercises and abdominal breathing patterns) follows by a set of seven movements, adapts from the eight-section brocade baduanjin exercise that originally comprises eight movements, repeated a certain number of times.the control group will receive the same aerobic exercises only

Eligibility criteria:
inclusion criteria: * • the subject selection will be according to the following criteria: * all patients of this study will be diagnosed as stroke and the diagnosis will be confirmed by computed tomography or mri (el-tamawy et al., 2021). * age of patients will be more than or equal 65years (males and females). * all patients will be hemodynamically stable. exclusion criteria: * • the potential participants will be excluded if they meet one of the following criteria: * patients who cannot follow instructions as sensory aphasia, blindness, dementia, and deafness. * patients with any orthopedic, neurological, or chest disorders that affect trunk muscles control or cause respiratory disorders as copd. * patients with psychiatric disorders. * patients with unstable cardiovascular conditions. * uncontrolled hypertension, or other concomitant respiratory diseases * participate at any research or rehabilitation program during the period of this study
to evaluate the safety and pharmacokinetic characteristics of aju-c714 and c714r in healthy adults

Conditions: Dyslipidemia

Summary: to evaluate the safety and pharmacokinetic characteristics of aju-c714 and c714r in healthy adults


Eligibility criteria:
inclusion criteria: 1. healthy adult over 19 years of age and under 65 years of age. 2. weight ≥ 50 kg (man) or 45 kg (woman), with calculated body mass index (bmi) of 18 to 30 kg/m2. 3. those who have no congenital chronic disease or chronic disease requiring treatment and who have no pathological symptoms or findings. 4. those who are eligible for clinical trials based on laboratory (hematology, blood chemistry, serum, urine test) and 12-lead ecg results during screening tests. 5. those who voluntarily decide to participate and agree to comply with the cautions after hearing and fully understanding the detailed description of this clinical trial. 6. those who agree to contraception during the participation of clinical trial. exclusion criteria: 1. those who take barbiturate and related (causing induction or inhibition of metabolism) drug within 1 month or the first administration of clinical trial drug within 10 days. 2. those who received investigational product or bioequivalence test drug within 6 months before the first administration of clinical trial drug. 3. those who donated whole blood within 8 weeks, received apheresis within 2 weeks, blood transfusion within 1 month or can't refrain from donating blood from the time of written consent until the end of the study. 4. those who has a history of gastrointestinal disease or surgery which may affect the absorption of the drug. 5. those who exceeding an alcohol consumption criteria alcohol: men - 21 glass/week, women - 14 glass/week (1 glass: soju 50 ml, beer 250ml or liquor: 30ml), smoke: 20 cigarettes/day. 6. those who has under * those who are hypersensitive to component of the investigational product and have the medical history * those with active liver disease or persistent elevation of aminotransferase levels of unknown * those with myopathy * those taking cyclosporin * those with renal impairment with severe renal failure * those with hypothyroidism * those who has genetic problems such as galactose intolerance, lapp lactose deficiency or glucose-galactose malabsorption 7. those who has a history of mental illness. 8. those who are deemed unfit by the investigators to participate in the clinical trial for other reasons. 9. women who are pregnant or who may be pregnant and breastfeed.
research on infarction with open arteries using oct and cmr

Conditions: Myocardial Infarction

Summary: the purpose of this study is to determine the prevalence of plaque disruption and to assess the composition of disrupted plaques in patients with myocardial infarction (mi) and non-obstructive coronary artery disease (cad) using optical coherence tomography (oct). additionally, cardiac magnetic resonance imaging (cmr) will be used to detect myocardial abnormalities, which will be correlated to oct findings to gain insight into the mechanisms of mi in patients with non-obstructive coronary artery disease (i.e. "open arteries").

in this single center, observational study, patients of both sexes with mi who are referred for cath will be enrolled. those who have no obstructive cad on clinically indicated coronary angiography, defined as no stenosis of \>50% in any major epicardial vessel, will undergo coronary oct just after the clinically indicated diagnostic angiogram, and cmr within 1 week, typically within 72-96 hours. participants will be followed for clinical events for at least 1 year. 20 fully eligble participants will be recruited at nyu langone medical center and bellevue hospital center among a projected 200 enrolled patients.

Eligibility criteria:
inclusion criteria: * acute ischemic symptoms compatible with diagnosis of acute coronary syndrome (acs) (chest pain or anginal equivalent symptoms at rest or new onset exertional anginal equivalent symptoms) * objective evidence of myocardial infarction (either or both of the following): elevation of troponin to above the laboratory upper limit of normal (uln) or st segment elevation of ≥1mm on 2 contiguous ecg leads * willing to provide informed consent and comply with all aspects of the protocol * age ≥ 21 years exclusion criteria: * stenosis ≥50% of any major epicardial vessel on invasive angiography, as determined by the angiographer at the time of clinically ordered cardiac cath. * history of known obstructive cad at angiography, including history of percutaneous coronary intervention (pci) or coronary artery bypass grafting (cabg) * recent use of vasospastic agents, such as cocaine, triptans, ergot alkaloids (≤1 month) * alternate explanation for troponin elevation, such as hypertensive urgency, acute exacerbation of heart failure, chronic elevation due to kidney disease, pulmonary embolism, cardiac trauma * coronary dissection apparent on angiography * excessive coronary tortuosity which, in the opinion of the angiographer, increases the risks of oct * egfr\<30 or contraindication to additional contrast needed for oct in the opinion of the angiographer or treating physician * contraindication to mri (including but not limited to mri-incompatible metal implants or foreign bodies) * pregnancy * thrombolytic therapy for stemi (qualifying event)

Keywords: myocardial infarction cad
self cranial electrical stimulation (ces) for pain in older adults with knee osteoarthritis (self ces for knee pain)

Conditions: Osteo Arthritis Knee

Summary: the purpose of this study is to determine the feasibility, safety, and preliminary efficacy of a two-week self cranial electrical stimulation(ces) on pain in older adults with knee osteoarthritis(oa)


Eligibility criteria:
inclusion criteria: * have self-reported unilateral or bilateral knee oa pain, according to american college of rheumatology criteria * have had knee oa pain in the past 3 months with an average of at least 30 on a 100 numeric rating scale (nrs) for pain * can speak and read english * have a device with internet access that can be used for secure video conferencing for real- time remote supervision * have no plan to change medication regimens for pain throughout the trial * are able to travel to the coordinating center * are willing and able to provide written informed consent prior to enrollment exclusion criteria: * history of brain surgery, brain tumor, seizure,stroke, or intracranial metal implantation * serious medical illness, such as uncontrolled hypertension (i.e., systolic blood pressure/ diastolic blood pressure ≥ 150/95 mm hg)heart failure, or history of acute myocardial infarction * alcohol/substance abuse * cognitive impairment * pregnancy or lactation * hospitalization within the preceding year for psychiatric illness
study comparing the safety and efficacy of piperacillin/tazobactam to cefepime in patients with hematologic malignancy or lymphoma

Conditions: Hematologic Neoplasms

Summary: to compare the safety and efficacy of piperacillin/tazobactam (4 g/500 mg) administered intravenously every 6 hours to cefepime (2 g) administered intravenously every 8 hours for the empiric treatment of neutropenic fever in patients with a hematologic malignancy or lymphoma.


Eligibility criteria:
inclusion criteria: * hospitalized male and female patients, 18 years of age or older * patients who have leukemia (acute lymphocytic leukemia \[all\], acute myelogenous leukemia \[aml\], chronic lymphocytic leukemia \[cll\], chronic myelogenous leukemia \[cml\]), that is newly diagnosed, who have had initial induction, re-induction, or intensification chemotherapy or who have had a bone marrow (allogenic, syngeneic, or autologous) or peripheral blood stem-cell transplant or patients with lymphoma, hodgkin's disease, multiple myeloma, myelodysplastic syndrome or myelodysplasia (refractory anemia \[ra\], refractory anemia with ringed sideroblasts \[rars\], refractory anemia with excess blasts \[raeb\], refractory anemia with excess blasts in transformation to leukemia \[raeb-t\], or chronic myelomonocytic leukemia \[cmml\]. * fever, defined as an oral temperature of ≥ 37.9°c /100.2°f, a rectal temperature ≥ 38.4°c /101.4°f, or a tympanic temperature ≥ 38°c /100.4°f exclusion criteria: * the presence of any clinically acute or chronic disease or condition that, in the opinion of the investigator, may interfere with the patient's ability to safely comply with the conditions of the protocol, or could preclude the evaluation of the patient's response or could make the completion of the therapy unlikely * neutropenia associated with syndromes that are not associated with a high risk of bacterial infection (eg. chronic benign neutropenia or kostmann's syndrome) * neutropenia due to primary bone marrow failure

Keywords: hematologic neoplasms
diet and physical activity program for type 2 diabetes mellitus

Conditions: Type 2 Diabetes

Summary: an individualized educational intervention are going to be developed. its based on the com-b model, designed and applied by primary care nursing professionals for patients with type 2 diabetes mellitus. its expected that participants, after a 6 month intervention, face to face and telephone, will improve their adherence to healthy behaviors related to diet and physical activity, their quality of life and the glycosylated hemoglobin figures.


Eligibility criteria:
inclusion criteria: * be cared for by one of the nurses participating in the research team * ability to complete the questionnaire * sign the informed consent * keep the primary care health center during till the end of the research
gene expression, immunological status and metabolome in glioma patients

Conditions: Glioma

Summary: study on glioma patients treated with brain surgery is focusing on the analysis of their transcriptome expression profile measured in two immune cell populations, cd4+ t cells and cd56+ nk cells. the results of analysis will be compared to the reference data of healthy population. furthermore, the metabolomic and immunological status will also be monitored and compared to healthy group reference data, before and after the surgery\*. with comparative crossomics analysis the investigators intend to possibly identify new diagnostic and prognostic biological markers for the relapse of the disease. the results are expected to convey a deeper insight into pathophysiology of the glioma as well as into the mechanisms of the current surgical therapy. \* the healthy reference data have been published in collaborative efforts of btc, umc and nib (gruden et al. 2012).


Eligibility criteria:
inclusion criteria: * malignant glioma = glioblastoma (who iv) patients exclusion criteria: * pregnancy * metastases

Keywords: glioma pbmc subpopulations gene expression metabolomics immunological status mirna proteomics
efficacy and safety curcumin in depression

Conditions: Major Depression

Summary: antidepressants generally do not lead to an immediate relief of symptoms. most people will not see a significant improvement for at least 4 weeks. studies have generally shown that the full benefits of antidepressant therapy may take as long as 8 to 12 weeks. however, this timeline is variable among individuals.curcumin is one of the main curcuminoids isolated from this perennial herb. it possesses a variety of pharmacological activities, including anti-inflammatory, antiproliferative, antioxidant, and neuroprotective effects. curcumin has been found to possess antidepressant action in various animal models of depression. chronic administration of curcumin has been reported to exert antidepressant-like action in olfactory bulbectomy model of depression in rats. although the mechanism of the antidepressant effect of curcumin is not fully understood, it is hypothesized that it acts through inhibiting the monoamine oxidase enzyme and modulating the release of serotonin and dopamine.in randomized, double-blind, placebo-controlled study 40 patients will be randomized to receive either 500 mg/day of curcumin or placebo together with antidepressants for 6 weeks.


Eligibility criteria:
inclusion criteria: males and females in age 20-60 years major depressive episode according to dsm-iv clinical global impression severity scale scores more than 4 hamilton depression rating scale scores more than 21 montgomery and asberg depression rating scale scores more than 22 ability and willingness to sign informed consent exclusion criteria: evidence of organic brain damage mental retardation alcohol or drug abuse an unstable medical condition any significant medical or neurological illness patients with a known hypersensitivity to curcumin or other components of the product pregnant women or women who intend to become pregnant receiving any antidepressant and mood-stabilizers

Keywords: antioxidants curcumin depression
tvto™ x tvts ™ for treatment of stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: this is a prospective, comparative randomized controled trial. the general purposes of this study is to compare the efficacy and safety of tvto™ and tvtsecur™ as surgical treatment for female urinary stress incontinence.


Eligibility criteria:
inclusion criteria: * clinical and urodynamic for stress urinary exclusion criteria: * detrusor overactivity (urodynamic study) * urodynamic changes suggesting reduced vesical capacity * associated neurological diseases * coagulopathies * pregnancy * foreign matter sensitiveness history * acute urinary tract infection * sequel from high ionizing radiation exposure * use of drugs that may result in high surgical risk and/or significant postoperative complication * anesthetic procedure contraindication * vulvovaginitis: presence of vaginal secretion with infection clinically or lab supported

Keywords: tvto tvtsecur mini sling stress urinary incontinence
analyze the relationship between the density of fat tissue and cellulite with the lumbar lordosis degree

Conditions: Lordosis

Summary: the aim of this study is analyze the relationship between the density of visceral and subcutaneous fat and cellulite with the lumbar lordosis degree.

there are two types of abdominal fat: subcutaneous adipose tissue which is more superficial, lying above the abdominal muscle wall and visceral adipose tissue, corresponding to the intra-abdominal fat witch is more harmful to health. the accumulation of fat tissue differs between genders and age. men have a huge propensity for developing central fat and women accumulate more subcutaneous fat tissue on the gluteal-femoral region. some authors suggest that the accumulation of fat tissue increases with age. several studies have concluded that there is a relationship between the abdominal fat storage and the degree of lumbar curvature. in addition, some authors also suggest that there is a relationship between the degree of lumbar lordosis and cellulite, which is related to circulatory changes. however these relationships are not yet clarified in the literature.

Eligibility criteria:
inclusion criteria: all the community of the school of allied health technologies; aged between 18-60 exclusion criteria: pathologies (cardiovascular, metabolic, cancer, respiratory, muscular); pregnancy; abdominoplasty; collum and gluteal surgeries; deregulated menstrual cycle ; anatomical changes; anticelulitic treatments

Keywords: central fat subcutaneous fat lumbar lordosis degree cellulite
thalamic recordings in children undergoing seeg

Conditions: Focal Epilepsy

Summary: stereoelectroencephalography (seeg) forms a key part of the pre-surgical evaluation in children who may be candidates for epilepsy surgery. it can help delineate the location of the putative epileptogenic zone, guiding further treatments including resective, disconnective and ablative epilepsy surgery techniques. however, less than 35% of children undergoing seeg end up becoming seizure free following further treatment. open and closed loop stimulation of thalamic nuclei via deep brain stimulation (dbs) and responsive neurostimulation (rns) are emerging treatment options for epilepsy. thalamic target nuclei vary between studies and there are currently no gold standard personalised methods for choosing a target. this stems from the limited systematic neurophysiological recordings from thalamic nuclei; investigators currently do not understand the ictal and interictal thalamic signatures of involvement in epilepsy and do not understand how functional connectivity can be altered within and between patients. in this prospective study, the investigators aim to recruit 30 patients undergoing seeg as part of their pre-surgical evaluation for drug resistant epilepsy at great ormond street hospital over a period of 3 years. once recruited, the investigators will target 3 nuclei bilaterally in each patient - the anterior, centromedian and pulvinar nuclei - using additional seeg electrodes. following clinical recording, the investigators will conduct two stimulation experiments, the first using single pulse electrical stimulation to measure effective connectivity between the thalamus and cortical regions and the second to study the effects of simulated dbs currents on cortical local field potential signatures. this study will lay the foundation for a personalised approach to thalamic neuromodulation for drug-resistant epilepsy by identifying neurophysiological biomarkers of thalamic involvement in epilepsy, paving the way for closed loop neuromodulation strategies that aim to optimise response using these biomarkers.


Eligibility criteria:
inclusion criteria: 1. all children undergoing seeg as part of their pre-surgical evaluation at gosh 2. participants/parents/legal guardian provide informed consent for inclusion exclusion criteria: 1) lack of informed consent
omegad (omega-3 and alzheimer's disease)

Conditions: Alzheimer's Disease

Summary: memory loss and difficulties with thinking associated with alzheimer's disease (ad) may be due to a deficiency in the brain of a fatty acid named dha. the aim of this trial is to see if dietary supplementation with a preparation, rich in dha, will halt cognitive impairment in ad patients


Eligibility criteria:
inclusion criteria: alzheimer's disease with mmse 15-30, living in own homes, treated with stable dose of acetylcholine esterase inhibitor for \>3 months and remaining on that treatment for the study period exclusion criteria: already treated with omega-3 fatty acids, nsaids, warfarin, being an alcohol abuser, suffering from serious concomitant disease or not having a caregiver

Keywords: alzheimer's disease omega-3 fatty acid dietary supplementation cognition safety
single versus multiple plastic stents in malignant distal bile duct obstruction

Conditions: Plastic Stent Occlusion

Summary: endoscopic retrograde cholangiopancreatography (ercp) with biliary stent placement is crucial for palliative treatment in patients with malignant bile duct obstruction who cannot perform surgery due to advanced diseases or associated comorbidities. stent patency is challenge in ercp. self expanding metallic stents (sems) have a longer duration of patency and fewer of recurrence occlusion of stent when compared with plastic stent (ps). however, the cost of ms is more expensive than ps about 4 times. therefore, many patients cannot afford the ms due to their economic status. data regarding the efficacy and safety of multiple ps compared with single ps for the palliative treatment in unresectable malignant distal bile duct obstruction are limited.

the aim of the current study is to compare the cumulative stent patency of multiple ps and single plastic stent and the clinical success rate as a primary objective, investigate the technical success rate, procedure time incident of overall adverse events including stent dysfunction and overall procedure related mortality as secondary outcomes.

Eligibility criteria:
inclusion criteria: in-operable distal malignant bile duct obstruction age\>18 exclusion criteria: pregnancy ecog 3-4 can not correct coagulopathy contraindicate for ercp

Keywords: plastic stent endoscopic retrograde cholangiopancreatography