Kornimate/medical-research-clean huggingface dataset:
significance of fluorescence colposcopy with autofluorescence imaging for cervical cancer

Conditions: Cervical Cancer

Summary: clinical trial to access significance of fluorescence colposcopy with autofluorescence imaging for the screening of cervical cancer

1. perform pelvic vaginal exam of the subjective to know symptom, illness history, physical exam and basal state before fluorescence colposcopy. 2. observe acetowhite epithelium and perform biopsy at suspicious lesion during fluorescence colposcopy. 3. perform fluorescence colposcopy again after biopsy and confirm extraordinary reaction. 4. after 1\~2weeks follow up the subjective at opd and confirm biopsy result.

Eligibility criteria:
inclusion criteria: 1. age : 20-65 years 2. abnormal cervical papanicolaou smear , no other specific cervical disease 3. subject to colposcopic biopsy or leep 4. signed voluntarily to informed concents with full knowledge after explanation abot objective, method, contents exclusion criteria: 1. pregnant women 2. porphyria 3. severe cervical bleeding 4. genital chlamydia, gonorrhea infection 5. other drug user with possible interaction (e.g. photosensitizer) 6. no informed consent

Keywords: fluorescence colposcopy cervical cancer
real-time pressure volume loop monitoring as a guide for enhanced understanding of changes in elemental cardiovascular physiology during therapeutic strategies aiming for hemodynamic optimization. cohort ii: structural heart interventions (pluto-ii)

Conditions: Heart Failure; Valvular Heart Disease; Aortic Stenosis; Mitral Insufficiency; Tricuspid Insufficiency

Summary: the aim of pluto-ii is to use biventricular pressure-volume (pv) loop measurements to improve the understanding of direct changes in cardiac and hemodynamic physiology induced by transcatheter aortic valve implantation (tavi) or tricuspid edge-to-edge repair (teer). these procedures evoke immediate changes in cardiac mechanoenergetics, ventricular-vascular interaction as well as ventricular (in)dependency. within the context of pluto-ii, patients will undergo biventricular pv-loop measurements before and after tavi or teer. in future, the application of perprocedural pv loop monitoring may tailor the daily individual decision making process during structural interventions in the catheterization laboratory.

pressure-volume (pv) loop monitoring is a tool allowing direct visualization of individual cardiac and hemodynamic physiology, including parameters reflecting cardiac mechanoenergetics (a derivative of the myocardial metabolic demand) as well as the ventricular-arterial coupling. the concepts of changing biventricular cardiac and hemodynamic physiology induced by structural heart interventions, including transcatheter aortic valve implantation (tavi), transcatheter edge-to-edge mitral repair (mitral teer) and transcatheter edge-to-edge tricuspid repair (tricuspid teer) are largely based on hypotheses, computer simulations and non-invasive (echocardiographic) estimations. pvl monitoring has the potential to identify unique characteristics of tavi, mitral teer and tricuspid teer from the perspective of changing baseline cardiovascular physiology, including (a change in) interference between both ventricles (i.e. the ventricular crosstalk). perprocedural (biventricular) pv loop monitoring can be of direct clinical relevance by appreciating the ventricular tolerance of increased cardiac afterload induced by the particular intervention in individual patients. in future, real-time pv loop analysis can be adjunctive to the individual decision-making process during routine structural interventions.

Eligibility criteria:
inclusion criteria: - adult patients undergoing elective transcatheter aortic valve implantation (tavi) or transcatheter edge-to-edge repair (teer). exclusion criteria: * confirmed or suspected (concomitant) congenital heart disease. * mechanical circulatory support (including impella, pulsecath, intra-aortic balloon counterpulsation or extracorporeal membrane oxygenation) was used during the procedure aiming to improve native cardiac output. * no (written) informed consent was obtained.

Keywords: pressure-volume loop cardiac mechanoenergetics
effects of kinesio taping and extracorporeal shock wave therapy in the calcaneal spur

Conditions: Calcaneal Spur; Plantar Fasciitis; Heel Pain

Summary: the term \&#34;heel pain\&#34; is used to describe a common, painful condition that is localized in the plantar part of the heel and worsens when weight is placed on the heel. patients with heel pain are more likely to have thickened plantar fascia, abnormal plantar fascia tissue, thicker plantar heel fat pad, and calcaneal spur. calcaneal spurs are bony protrusions that typically occur just in front of the medial calcaneal tuberosity. systemic medical treatments, physical therapy agents, exercise and local injections are often applied for heel pain caused by plantar fasciitis and calcaneal spur. this study is to examine the effects of eswt and kinesio taping on pain and other clinical outcomes in patients with calcaneal spurs.

the responses of patients who underwent eswt or kinesio taping due to calcaneal spur before and after treatment will be compared. pain, functionality and quality of life are the clinical parameters compared.

Eligibility criteria:
inclusion criteria: * aged 18 years and over with heel pain * a calcaneal spur seen on foot radiographs exclusion criteria: * those who had received a steroid injection into the heel within the past three months * those who had experienced trauma or surgery to the foot and ankle within the past six months * those with a rheumatic disease affecting the foot and ankle (e.g., spondyloarthritis) * those with open wounds or infections in the area to be treated with lesions.

Keywords: calcaneal spur extracorporeal shock wave therapy kinesio taping plantar fasciitis
analysis of passive leg raise test on blood pressure in critically ill patients.

Conditions: Shock; Hypovolemia; Hemodynamic Instability

Summary: positioning intensive care patients in trendelenburg position to identify fluid responsiveness assessed by picco device.

it is a prospective observational study. patients admitted to intensive care unit of university clinical centre of gdańsk, receiving advanced hemodynamic monitoring with picco method will be enrolled. after blood pressure measurement, picco will be calibrated with transpulmonary thermodilution with 10 - 20 ml of cold saline. readings will be noted. the patient will be positioned in trendelenburg position with it's head 15 degrees down. the increase of blood pressure after positioning in relation to the values obtained before the trial will be correlated to the parameters that asses patent's volaemia. after 5 minutes patient will be back to supine position and hemodynamic parameters will be recorded for another 5 minute.

Eligibility criteria:
inclusion criteria: * hemodynamic instability * mechanical ventilation exclusion criteria: * increased intracranial pressure * increased intraabdominal pressure * lower limbs sequential compression system * agitation * patients exposed to pain stimulus before the test * aortic aneurysm * left to right cardiac shunt * severe valvular insufficiency
theory based integrated program on medication adherence among community dwelling schizophrenia

Conditions: Schizophrenia; Medication Adherence; Medication Compliance

Summary: this clinical trial aims to evaluate the effectiveness of the theory-based integrated program in promoting medication adherence in patients with schizophrenia. the purpose of this study are: * to explore the effectiveness of the theory-based integrated program in promoting community-based schizophrenia patients' adherence to medication(like :motivation, attitude and behavior) * to explore the effectiveness of the theory-based integrated program in improving the psychiatric symptoms of patients with schizophrenia in the community. participants (the experimental group) received routine home visits from psychiatric mental nurses, including drug administration, drug side effects and symptom management, life care, and the theory-based program provided by the researcher(treatment as usual + the theory-based integrated program). the comparison group: received routine home visits from psychiatric mental nurses, including drug administration, drug side effects, and symptom management, life care,(treatment as usual).

members of the experimental group received routine home visits, plus a 1-hour the theory-based program intervention 12 times in the 1st, 3rd, 5th, 7th, 9th, 11th, 13th, 15th, 17th, 19th, 21st, and 23rd weeks, and each patient received a total of 12 hours of intervention. the control group received routine home visits by psychiatric mental nurses, and the nurse provided patients with answers to questions about medications or care and handling of life events. the visits and intervention time frequency were the same as those in the experimental group. both groups were received baseline (t0), after the 6th hours intervention (t1) and 12th hours intervention by nurses to collect data on the main outcome variables: adherence to medication, mental symptoms, motivation to take medication, and attitude towards medication.

Eligibility criteria:
inclusion criteria: 1. diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) diagnosis of schizophrenia group, including schizophrenia, affective schizophrenia (schizoaffective disorder); 2. age between 20 and 64 years old; 3. at least one oral antipsychotic drugs; 4. living in the community, not participating in day wards, community rehabilitation centers and other rehabilitation institutions on weekdays, no psychiatric outpatient clinics, only home visits by home nurses; 5. those who can communicate in chinese and taiwanese exclusion criteria: 1. those who have a diagnosis related to organic problems, substance abuse, dementia or mental retardation, and are unable to communicate; 2. those who have received long-acting injections from the psychiatric department. -

Keywords: schizophrenia, medication adherence, randomized control trail,community, schizophrenia
pilot study evaluating neuro-imaging correlates of epigenetic finding in prediction of chronic postsurgical pain

Conditions: Chronic Post-surgical Pain

Summary: this pilot research study is being performed to learn more about pain and look at how pain changes brain chemistry and function. the research team would like to learn new information to better control chronic pain after surgery. this information collected in this research will be used to plan possible future visits. participants in this study are being asked to participate because they are scheduled for an upcoming surgery. the research team would like to observe them before and after their surgery.

this study is a pilot feasibility study in 30 healthy, preoperative children and young adults undergoing major surgery with high risk for chronic post-surgical pain (cpsp) to characterize the brain metabolite status of the anterior cingulate cortices (acc) and insula in pre-surgical adolescents and to understand the relationship between metabolite levels and cpsp. the investigators will also examine whether neurochemical tone in these regions is related to resting state functional connectivity with other brain regions. correlations between differentially methylated cpg sites in genes enriching gamma aminobutyric acid (gaba) and dopamine-darpp-32 pathways and glu/gaba levels in insula/acc will be analyzed.

Eligibility criteria:
inclusion criteria: 1. male or female aged ≥ 8 yrs of age 2. english speaking; 3. healthy (defined as american society of anesthesiologists physical status 1 or 2) 4. ability to provide assent/consent/parent permission. 5. scheduled to undergo chest surgery (thoracotomy, thoracoscopy, nuss procedure, pectus surgery, mastectomy), spine surgery, amputation, hernia repair or hip/knee replacement. exclusion criteria: 1. history of chronic pain conditions including migraines 2. use of opioids chronically or for major surgery within the 6 months prior to enrollment 3. severe obesity (bmi\>35 kg/m2) 4. taking no more than two concomitant medications known to induce or inhibit cyp2d6 activity, including paroxetine, fluoxetine, cimetidine, and duloxetine or other medications used to treat attention deficit hyperactivity disorder (medications containing amphetamine or methylphenidate). 5. use of hormonal contraceptives 6. use of medications that may alter pain sensitivity (e.g. gabapentin,/pregabalin amitryptiline/other antidepressants, clonidine). 7. active or history of renal/liver problems or congenital cardiac disease 8. diagnosed developmental delay 9. pregnant or lactating females 10. any skin condition that prevents cuff application 11. history of seizures 12. claustrophobia 13. metallic implants/orthodontics/braces or other mri exclusion (mri safety screening will be conducted prior to enrollment and prior to each mri scan)
prp in recurrent implantation failure

Conditions: Recurrent Implantation Failure

Summary: the endometrial function and endometrial receptivity have been accepted to be major limiting factors in the establishment of pregnancy. in spite of improved almost all aspects of ivf: ovarian stimulation, embryo culture and transfer, the pregnancy rates still not satisfactory. the bottleneck is the process of implantation. recurrent implantation failure (rif) is one of the nightmares in reproductive medicine and despite several strategies that have been described for management; there is no universal agreement yet. recently, intrauterine infusion of platelet-rich plasma (prp) is described to promote endometrial growth and receptivity, prp has been investigated as a therapeutic approach for several medical disorders in dermatology and rheumatology, but its use in ivf is still limited. objective: to evaluate the effectiveness of intrauterine perfusion of autologous platelet-rich plasma in the improvement of pregnancy rate in rif patients.

after ethical committee approval was obtained, 150 infertile women with history of rif gave their written consent to be included in this study. all were recruited from the outpatient clinic of al-baraka fertility hospital - with age below 40 yrs, body mass index (bmi) below 30 kg/m2, whose uteri were morphologically normal as confirmed by hsg and u/s to limit additional factors that may affect the results of the study - divided into 2 comparable groups; all participants underwent antagonist protocol, oocytes retrieval, fertilization and embryo transfer; in the study group, intrauterine infusion of 0.5 to 1 ml of platelet-rich plasma (prp) was performed 48 hrs before blastocyst transfer, pregnancy tests were done 12 days after et.

Eligibility criteria:
inclusion criteria: * female infertile patients with history of recurrent implantation failure * age below 40 yrs., * body mass index (bmi) below 30 kg/m2. exclusion criteria: * haematological and immunological disorders * hormonal disorders, * chromosomal and genetic abnormalities and uterine abnormalities (acquired or congenital) as confirmed by hsg and u/s to limit additional factors that may affect the results of the study

Keywords: recurrent implantation failure implantation ivf platelet rich plasma (prp)
early exercise training in critically ill patients

Conditions: Critical Illness; Intensive Care; Muscle Weakness; Deconditioning

Summary: this randomized controlled trial was designed to investigate whether a daily training session using a bedside cycle ergometer, started early in stable critically ill patients with an expected prolonged icu stay, could induce a beneficial effect on exercise performance, quadriceps force and functional autonomy at icu and hospital discharge compared to a standard physiotherapy program.

inactivity during prolonged bed rest leads to muscle dysfunction. muscle function decreases even faster in icu patients due to inflammation, pharmacological agents (corticosteroids, muscle relaxants, neuromuscular blockers, antibiotics), and the presence of neuromuscular syndromes, associated with critical illness. a recent recommendation document advices to start early with active and passive exercise in critically ill patients. however, no evidence is available concerning the feasibility of an early muscle training intervention in the acute icu phase when patients are still under sedation. a rather new method to train bed-bound patients is the use of a bedside cycle ergometer. this randomized controlled trial was designed to investigate whether a daily training session using a bedside cycle ergometer, started early in stable critically ill patients with an expected prolonged icu stay, could induce a beneficial effect on exercise performance, quadriceps force and functional autonomy at icu and hospital discharge compared to a standard physiotherapy program.

Eligibility criteria:
inclusion criteria: * icu stay \> 5 days * expected prolonged stay of at least 7 more days * cardiorespiratory status that allows at least passive exercise therapy exclusion criteria: * persistent or progressive neurological or (neuro)muscular disease * coagulation disorders (inr \> 1.5, \[bp\] \< 50000/mm³) * intracranial pressure \> 20 mmhg * psychiatric disorders or severe confusion

Keywords: exercise therapy physiotherapy critical illness intensive care muscle weakness mechanical ventilation
intraoperative lung-protective ventilation in neurosurgery

Conditions: Ventilator-induced Lung Injury

Summary: the purpose of this study is to explore the effectiveness of lung-protective ventilation during general anesthesia for neurosurgical procedures on postoperative pulmonary outcome, compared with traditional ventilation.

after screened for preoperative risk classification of postoperative respiratory complications,360 patients undergoing elective neurosurgery are randomly assigned to two groups, lung-protective ventilation (l) and traditional ventilation(t).patients are mechanical ventilated with either a tidal volume of 10-12 ml/kg ideal body weight (ibw,t) or 6-8ml/kg ibw with 6-8 cm h2o peep(l),both with recruitment maneuver (rm).each rm consists of applying a continuous positive airway pressure of 30 cmh2o for 30 seconds. postoperative pulmonary complications are compared between groups.

Eligibility criteria:
inclusion criteria: 1. \> 40 years ,and \< 80 years 2. scheduled for neurosurgery 3. after informed consent has been obtained 4. with an expected duration of ≥ 4 hours 5. preoperative risk index for pulmonary complications≥ 2 6. glasgow coma scale \>8 exclusion criteria: 1. mechanical ventilation of \> 1 hour within the last 2 weeks before surgery 2. body mass index ≥ 35 kg/m2 3. acute respiratory failure (pneumonia, acute lung injury or acute respiratory distress syndrome) 4. emergency surgery 5. severe cardiac disease 6. progressive neuromuscular illness 7. pregnancy 8. refusal to participate

Keywords: protective mechanical ventilation ventilator-induced lung injury neurosurgery
prognostic value of hemodynamic disturbances in rhegmatogenous retinal detachment (crado-red)

Conditions: Retinal Detachment

Summary: retinal detachments correspond to a separation of the neuroepithelium from the pigment epithelium. they can be exudative (sometimes in conjunction with a tumor), tractional, traumatic (postoperative) or rhegmatogenous (in relation to a tear). ultrasound, requested when the fundus is difficult to achieve and shows a hyperechoic mobile membrane. it can also measure the hemodynamic parameters of retinal arteries. a preliminary study showed a correlation between systolic velocity in the central retinal artery and postoperative visual acuity. the aim of this study is to confirm those preliminary data.


Eligibility criteria:
inclusion criteria: * patients over 18 years * rhegmatogenous retinal detachment, relapsing or not, including pseudophakic retinal detachment or aphakic retinal detachment, if the retinal detachment occurs more than three months after phacoemulsification exclusion criteria: * traumatic retinal detachment * bilateral retinal detachment * less than 3 months after phakoemulsification * predictable follow-up of less than 6 months * patient under of legal protection * patient's opposition to participate * absence of affiliation to the social security * eye's axial length\> 25.5 mm * preoperative visual acuity greater than 70/100 * no surgery
a trial comparing the incidence of hypophosphatemia in relation to treatment with iron isomaltoside and ferric carboxymaltose in subjects with iron deficiency anaemia due to inflammatory bowel disease

Conditions: IBD

Summary: treatment with iron isomaltoside and ferric carboxymaltose in subjects with iron deficiency anaemia due to inflammatory bowel disease and comparison of the incidence of hypophosphatemia

existing iv iron complexes differ in relation to the compounds capability to induce unintended hypophosphatemia to a degree defined as medical significant. this trial is designed evaluate the effect of iv iron isomaltoside compared to iv ferric carboxymaltose on phosphate in subjects with ida due to inflammatory bowel disease .

Eligibility criteria:
inclusion criteria include: * men or women ≥ 18 years * subjects diagnosed with ibd * hb \< 13 g/dl * body weight ≥ 50 kg * s-ferritin \<100 ng/ml * egfr ≥ 65 ml/min/1.73 m2 * s-phosphate \> 2.5 mg/dl * oral iron preparations are ineffective or cannot be used or where there is a clinical need to de-liver iron rapidly * willingness to participate and signing the informed consent form (icf) exclusion criteria include: * anaemia predominantly caused by factors other than ida according to investigator's judgment * hb ≥ 10 g/dl and body weight \< 70 kg * hemochromatosis or other iron storage disorders * known hypersensitivity reaction to any component of iron isomaltoside or ferric carboxymaltose * previous serious hypersensitivity reactions to any iv iron compounds * treatment with iv iron within the last 30 days prior to screening * treatment with erythropoietin or erythropoietin-stimulation agents, red blood cell transfusion, radiotherapy, and/or chemotherapy within the last 30 days prior to screening * received an investigational drug within the last 30 days prior to screening * planned surgical procedure within the trial period * hepatic enzymes \> 3 times upper limit of normal * surgery under general anaesthesia within the last 30 days prior to screening * any non-viral infection within the last 30 days prior to screening * alcohol or drug abuse within the past 6 months * untreated hyperparathyroidism * kidney transplantation * conditions that interfere with the subject's ability to understand the requirements of the trial and/or presumable non-compliance * any other laboratory abnormality, medical condition, or psychiatric disorders which, in the opinion of the investigator, will put the subject's disease management at risk or may result in the subject being unable to comply with the trial requirements * pregnant or nursing women.