Kornimate/medical-research-clean huggingface dataset:
impact and mechanism of depression on cardio-cerebral vascular events and arteriovenous fistula dysfunction in mhd patients

Conditions: Cardio-cerebral Vascular Events; Arteriovenous Fistula Dysfunction

Summary: depression is a common psychiatric disorder in patients on maintenance hemodialysis (mhd). it may contribute to poor prognosis in a number of ways, including its effect on platelet function. we aimed to investigate the impact and underlying mechanisms of depression on the occurrence of cardio-cerebral vascular events (ccve) and dysfunction of arteriovenous fistula (davf) in mhd patients. in this study, mhd patients were recruited and divided into depression and non-depression groups using the hamilton depression scale (hamd) in this prospective cohort study. their clinical and laboratory indicators were collected and the occurrence of ccve and davf were recorded through clinical follow-up, and analyzed, and the differences and possible influencing factors of ccve and davf occurrence were assessed between the two groups of patients.


Eligibility criteria:
inclusion criteria: * patients had undergone dialysis treatment for more than 3 months, and their medical status was stable at the time of enrollment, with an expected survival period of more than 1 year exclusion criteria: * (1) with communication disorders or mental illness other than depression; (2) a combination of cirrhosis, lymphoma, thrombocytopenic purpura, or other diseases that significantly affect platelet function; (3) complicated with malignant tumors, tuberculosis, severe heart failure, and unstable medical conditions; (4) inability or unwillingness to cooperate with researchers.

Keywords: maintenance hemodialysis patients depression cardio-cerebral vascular events arteriovenous fistula dysfunction platelet
effectiveness of nanoone woman underwear using in the management of dysmenorrhea

Conditions: Dysmenorrhea

Summary: to evaluate the mean change in menstrual pain intensity during menstrual cycles from baseline after wearing nanoone woman underwear in women with primary dysmenorrhea

the severity of dysmenorrhea pain experienced by subjects will be evaluated on a vas, ranging from zero (no pain) to ten (very severe pain). subjects will be asked to use the vas scoring system to record, on a provided sheet, their experienced menstrual pain level daily during menstrual bleeding for a total of three consecutive menstrual cycles.

Eligibility criteria:
inclusion criteria: 1. females aged below 40 years old. 2. screened by inquiry and diagnosed as primary dysmenorrhea by gynaecologist with pelvic ultrasonography. 3. female subject who is: * using adequate contraception since last menstruation and no plan for conception during the study. * non-lactating. * has negative pregnancy test (urine) within 14 days prior to the study. 4. informed consent form signed. exclusion criteria: 1. sensitivity to study product. 2. patient has been diagnosed with secondary dysmenorrhea (defined as identifiable pelvic pathology). 3. patient has clinically significant physical disability or abnormal findings on physical examination or laboratory testing judged by the investigator or co-investigator. 4. participation of any clinical investigation during the last 30 days.
comparative evaluation of the effect of prophylactic intraligamentary injection of dexamethasone and piroxicam on postoperative pain in teeth with symptomatic irreversible pulpitis

Conditions: Postoperative Pain

Summary: the study is conducted to assess and compare the efficacy of local intraligamentary injection of glucocorticoids(dexamethasone) and nsaid(piroxicam) on reduction of postoperative pain in patients with symptomatic irreversible pulpitis.


Eligibility criteria:
inclusion criteria: 1. systemically healthy patient (asa i or ii). 2. mandibular posterior teeth with: * preoperative sharp pain. * absence of widening in the periodontal ligament (pdl). * vital response of pulp tissue to cold pulp tester (ethyl chloride spray). exclusion criteria: 1. patients allergic to anesthetics, piroxicam (any other nsaids) or dexamethasone (other corticosteroids). 2. pregnant or nursing females. 3. patients having significant systemic disorder (asa iii or iv). 4. hemostatic disorders or anti-coagulant therapy during the last month. 5. consumption of opioid or non-opioid analgesics or corticosteroids during the last 12 hrs before treatment. 6. retreatment cases.
value of diaphragmatic motion measurement at ultrasonography to predict poor prognosis in emergency department patients with acute respiratory failure

Conditions: Dyspnea; Acute Respiratory Failure

Summary: acute respiratory failure is one of the most common diagnosis in patients admitted in the emergency department. acute respiratory failure is associated with morbidity and mortality. fifteen percent of patient will require ventilatory support and among them 40% will die. measurement of diaphragmatic motion (excursion) at ultrasonography is a noninvasive measure, allowing to assess diaphragm dysfunction. it could be useful in predicting poor prognosis in ed patients with respiratory failure . in this study the investigators will compare the prognostic value of diaphragmatic excursion measurement at ultrasonography to that of the national early warning score (news) 2 in patients presenting with acute respiratory failure in the ed the investigators made the hypothesis that measurement of diaphragmatic excursion in ed patients with acute respiratory failure could be of value in predicting the need for ventilatory support or mortality within 28 days from ed admission

diaphragmatic dysfunction can be explored by measuring diaphragmatic excursion using ultrasonography in spontaneous ventilation patients. patients in spontaneous ventilation will undergo both diaphragmatic excursion measurement at ultrasonography and assessment of the news2 score as part of standard care.

Eligibility criteria:
inclusion criteria: * age equal or over 18 y.o * signs of acute respiratory failure defined by rr equal or over 25 br/min and/or signs of increased work of breathing * patients on spontaneous breathing exclusion criteria: * medical history of diaphragmatic dysfunction including stroke or diaphragmatic paralysis * patients on ventilatory support at ed admission or prior to inclusion * patients treated with curare * trauma patients

Keywords: diaphragmatic excursion diaphragmatic dysfunction emergency department respiratory insufficiency acute respiratory failure
bioimpedance measurement of abdominal free flaps during arterial and venous weaning in breast reconstruction

Conditions: Breast Reconstruction; Thrombosis, Venous; Bioimpedance Measurement Capacity

Summary: as the occurrence of thrombosis in post surgery is rare, it seemed difficult to study only this one. this is why we decided to test the bioimpedance, temperature and green, red and infrared light absorption measurements of the prototype during the weaning of the flap during surgery. indeed, during weaning the investigators voluntarily interrupt the arterial and venous flow to transfer the flap to the breast. this weaning corresponds to a thrombosis model. the patients will benefit from an "improved" postoperative monitoring. indeed, in addition to the classical clinical monitoring, they will benefit from an additional monitoring during 5 days thanks to the realization of an ultrasound of the flap which will be carried out every 6 hours the first 24 hours then every 12 hours. this protocol is therefore a feasibility study for the collection of data of interest.


Eligibility criteria:
inclusion criteria: * woman undergoing microsurgical breast reconstruction using a free abdominal flap * age greater than or equal to 18 years exclusion criteria: * pregnant patient * patient with an active implantable device such as a pacemaker or an artificial heart * patient refusing to participate in the study * age less than 18 years old

Keywords: breast reconstruction thrombosis, venous bioimpedance measurement capacity
physiological study to compare noninvasive ventilation (niv) masks

Conditions: Sleep-disordered Breathing; Hypercapnia

Summary: noninvasive ventilation (niv) is an established therapy that delivers positive pressure to the upper airways to provide respiratory support. two types of niv can be delivered; continuous positive airway pressure (cpap) at one continuous pressure and bilevel niv at two pressures for inhalation and exhalation. this investigation is designed to physiologically evaluate the performance of a niv mask, mask a, compared to a standard niv mask, mask b on cpap therapy. people with sleep disordered breathing who have chronic hypercapnia, and are already receiving nocturnal cpap will be recruited. they will receive one night's cpap therapy on mask a and 1 night on mask b in random order. physiological parameters will be recorded. parameters will be recorded during three baselines at the beginning of each evening and throughout the night when participants are asleep. the three baselines are: 1. participant awake with normal breathing (not on cpap), 2. participant awake and on cpap, and 3. participant asleep on cpap in rem-sleep (rapid eye movement sleep).


Eligibility criteria:
inclusion criteria: * already using overnight cpap and tolerating the therapy well (over 4 hours use/night) * hypercapnia: venous bicarbonate of 30 milliequivalents of solute per liter (eq/l) or more, or transcutaneous carbon dioxide (tcco2) of 50 millimeters of mercury (mmhg) of more. * provide written informed consent * already use a full (oronasal) face mask for cpap * willing to have a venous blood sample taken during the pre-screening visit. exclusion criteria: * presence of sleep apnea on cpap: * subjects excluded if they have an apnea-hypopnea index (ahi) of more than 20, or * if the ahi has not already decreased by 50 percent or more from pre-cpap to with cpap. * forced expiratory volume in 1 second (fev1) of less than 40 percent of predicted. * forced expiratory volume in 1 second divided by forced vital capacity (fev1/fvc) less than fifty percent of predicted, at the screening visit. * have poorly controlled asthma or changing asthma symptoms. * nasal obstruction * do not fit mask a or mask b * agitation or psychological illness
one point versus two point fixation of tripodal zygomatic fractures

Conditions: Assessment of Proper Union of Fractures

Summary: the zygomatic bone defines the anterior and lateral projection of the face and articulates with the frontal, sphenoid,temporal, and maxillary bones. the zygomatic complex is responsible for the protection of the orbital contents and the mid-facial contour. fracture of the zygomatic complex is one of the most common facial injuries in maxillofacial trauma and predominately appears in young adult males. the etiology of zygomatic complex fractures primarily includes road traffic accidents, violent assaults, falls and sports injuries. the main clinical features of zygomatic complex fractures include diplopia, enophthalmos, subconjunctival ecchymosis, extraocular muscle entrapment, cosmetic deformity with depression of the malar eminence, malocclusion and neurosensory disturbances of the infraorbital nerve. diagnosis of zygomatic complex fractures is usually clinical with confirmation by computed tomography (ct) scan. zygomatic complex fractures with no or minimal displacement are often treated without surgical intervention, whereas fractures with functional or esthetic impairments often necessitate surgical intervention. various surgical approaches and treatment strategies have been proposed to obtain successful treatment outcome, including the gilles temporal approach, eyebrow, upper eyelid, transconjunctival, infraciliary lower eyelid, and intraoral vestibular approaches. the surgical approach for adequate reduction of zygomatic complex fractures must ensure a good functional and cosmetic result. surgical reduction of zygomatic fractures by an intraoral surgical approach was first described in1909 by keen, and several studies have subsequently documented the treatment outcome after open reduction of zygomatic complex fractures by an intraoral surgical approach.

this study is a prospective clinical intervention study where the admitted patients do lab investigation as cbc, coagulation profile ,kidney function test and imaging as ct maxillofacial with axial and coronal cuts. patients will be assigned randomly into either one of the two groups under the study using concealed envelope. under general anaesthesia with oral or naso-tracheal intubation, open reduction and internal fixation of tripod zygomatic fractures will be done using miniplates and screws at one point (zygomaticomaxillary area) or at two points (zygomaticomaxillary and frontozygomatic areas).

Eligibility criteria:
inclusion criteria: * (a) adult patients with maxillofacial fractures including tripodal zygomatic fractures as determined on clinical and radiological finding (b) isolated tripodal fracture zygoma exclusion criteria: * patients with le fort i/ii/iii fractures
malignant obstruction zilver against routine therapy (mozart i)

Conditions: Biliary Tract Neoplasms; Pancreatic Neoplasms; Jaundice, Obstructive

Summary: this study compares the 6 mm nitinol zilver biliary endoprostheses and the 10 mm nitinol zilver biliary endoprostheses to the 10 mm wallstent in appropriate patients in need of palliative treatment of malignant obstructive jaundice.

this research is being done to determine if the new, fda-cleared zilver metal biliary stent is better than the conventional stents. the new zilver stent may permit more accurate placement, may avoid some potential complications and last longer than the conventional stents. the study will also examine to find the best diameter of stent by comparing standard 10 mm stents to 6 mm zilver stents.

Eligibility criteria:
inclusion criteria: * unresectable malignancy of the extrahepatic bile duct exclusion criteria: * age below 21 years * pregnancy * active alcohol or drug abuse * simultaneously participating in another investigational drug or device study. * allergy to stainless steel or nitinol * active cholangitis * brachytherapy * unable or unwilling to comply with follow up

Keywords: stents stent-graft minimally invasive biliary tract cancer pancreatic cancer jaundice biliary tract neoplasms pancreatic neoplasms jaundice, obstructive zilver
vascular endothelial protection effects of dextromethorphan

Conditions: Atherosclerosis; Smoking; Inflammation

Summary: to test the hypothesis that dm could have anti-inflammatory effect and thus achieve vascular protection effect on heavy smokers.

dextromethorphan (dm), an ingredient widely used in antitussive remedies, had been reported to reduce the inflammation-mediated degeneration of neurons. we recently found that dm can prevent vascular remodeling and neuron injury in animal models of carotid ligation and cerebral ischemia injuries, respectively. it was believed that its action was through the anti-oxidant and nadph pathway to protect brain cells. however, the mechanism and actual effect on human vascular protection remained unclear. to test the hypothesis that dm could have anti-inflammatory effect and thus achieve vascular protection effect on heavy smokers, this prospective study will be conducted to treat subjects with heavy smoking history with dm or not and evaluate the anti-inflammatory and the improvement of endothelial function.

Eligibility criteria:
inclusion criteria: * healthy male volunteers who are currently smoking exclusion criteria: * personal history of hypertension or diabetes mellitus * family history with * documented premature cardiovascular events * cardiovascular-associated sudden death * total cholesterol \> 240 mg/dl * triglyceride \> 200 mg/dl * low-density lipoprotein \> 160 mg/dl.

Keywords: endothelial function atherosclerosis smoking inflammation antioxidant
incidence rate of perioperiative vte in colorectal cancer patients : a multicenter prospective observational cohort study

Conditions: Incidence Rate of Perioperiative Venous Thromboembolism(VTE) in Colorectal Cancer Patients

Summary: this is a multi-centered, prospective, observational study aimed at observing the incidence rate of perioperiative vte in colorectal cancer patients


Eligibility criteria:
inclusion criteria: * patients in colorectal surgery ward clinical diagnosis of colorectal cancer prepare for radical colorectal surgery. exclusion criteria: * patients prepare for emergency surgery clinical diagnosis of benign colorectal disease patients who have joined other clinic studys

Keywords: venous thromboembolism colorectal cancer
random evaluation of patients who have had laparoscopic partial nephrectomy

Conditions: Kidney Cancer

Summary: the purpose of this study is to evaluate the necessity of using hemostatic agents as a tool when performing robotic partial nephrectomy in the treatment of kidney cancer. this project asks whether patients who undergo robotic partial nephrectomy without the surgeon using hemostatic agents during the procedure will have the same, fewer, or more complications than when patients undergo this same surgery with the surgeon using hemostatic agents during the procedure.


Eligibility criteria:
inclusion criteria: 1. male and female patients aged 18 years and older. 2. patients must have a solid or cystic renal mass suspicious for malignancy by imaging with ultrasound, computed tomography (ct) scan, or magnetic resonance imaging (mri). 3. patients must be initially scheduled ralpn as opposed to radical nephrectomy or other techniques for partial nephrectomy such as open surgery or pure laparoscopy without robot assistance. 4. patients with bilateral kidneys or a solitary kidney, so long as these are native kidneys as opposed to a transplanted kidney. 5. patients can have the common single renal artery and single renal vein, or they can have common variants such as two renal arteries and/or two renal veins. exclusion criteria: 1. patients on hemodialysis. 2. patients who have had a renal transplantation. 3. patients on therapeutic anticoagulation prior to surgery (example anticoagulants include: aspirin 325 mg daily, clopidogrel, warfarin, fondaparinux, dabigatran, and rivaroxaban). however, patients who take aspirin 81 mg daily as their daily regimen will be included. 4. patients with bleeding disorders (example: hemophilia) and other documented coagulopathy (example: chronic liver disease) with inr greater than 1.0 at baseline. 5. patients who have had a prior surgical procedure, aside from percutaneous renal biopsy, on the kidney in the current operation. 6. patients with over 100 ml of estimated blood loss (calculated by anesthesia team using the suction canisters) prior to clamping of the renal hilum will be excluded.
clinical importance of filaggrin gene mutation for treatment outcome in atopic dermatitis

Conditions: Atopic Dermatitis

Summary: atopic dermatitis is a common disease which affects about one million people in finland at some stage of their life. in atopic dermatitis we see a superficial inflammation of the skin and a defect in skin barrier function. the filaggrin protein plays a central role in the skin barrier function and studies indicate that about 30% of patients with atopic dermatitis have a mutation in the filaggrin gene. the aim of the study is to investigate whether a mutation in the filaggrin gene affects the clinical treatment outcome in patients with atopic dermatitis. if a mutation predisposes to a worse response to treatment, this could be examined and those patients with the mutation could be given extra treatment support for their atopic dermatitis. the prevalence of filaggrin mutation in the finnish non-atopic population is studied in the control group.


Eligibility criteria:
inclusion criteria (patients with atopic dermatitis): * age at least 18 years * clinical diagnosis of atopic dermatitis * need for follow-up at the skin and allergy hospital * patient gives signed informed consent to participate in this study * patients parents and grandparents are of finnish origin inclusion criteria (controls): * no history of atopy or skin disease * age at least 18 years

Keywords: atopic dermatitis filaggrin
iccrt vs. crt for locally advanced nasopharyngeal carcinoma

Conditions: Locally Advanced Nasopharyngeal Carcinoma

Summary: this trial is a multi-center phase iii clinical trial. the purpose of this trial is to explore whether concurrent chemoradiotherapy is not inferior to induction chemotherapy combined with concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma.


Eligibility criteria:
inclusion criteria: 1. age 18-65 years old; 2. pathologically confirmed non-keratinizing nasopharyngeal carcinoma; 3. stage t3-4n0-1 (according to the uicc/ajcc 8th); 4. no distant metastasis; 5. have not received anti-cancer treatment in the past; 6. ecog (eastern cooperative oncology group of the united states): 0-1; 7. adequate hematologic, hepatic and renal function. exclusion criteria: 1. the purpose of treatment is palliative; 2. diagnosed with other malignant tumors at the same time; 3. malignant tumor history; 4. pregnancy or breastfeeding, or expect to become pregnant during the clinical trial period; 5. combined serious illness.
toileting at night in older adults: light to maximize balance, minimize insomnia

Conditions: Falls; Balance; Insomnia; Aging

Summary: to examine the change in balance that occurs in older individuals when exposed to different colored lights at night.


Eligibility criteria:
inclusion criteria: * aged 55-85 * stable health * normal color vision exclusion criteria: * alcohol abuse * depression * sleep disorders * smoking * use of illegal drugs

Keywords: postural balance sleep initiation and maintenance disorders