Kornimate/medical-research-clean huggingface dataset:
use of fototherapy in the treatment of fissure in ano

Conditions: Fissure in Ano

Summary: the eligible population consisted of individuals with anal fissure awaiting surgical intervention. individuals aged 18 years or older were included, diagnosed with anal fissure and who voluntarily agreed to participate in the research. those who had some pelvic inflammation and who had already undergone a surgical procedure and had recurrence were excluded from the studythe selected individuals underwent a standardized anamnesis of the service, answered questionnaires on symptoms of intestinal constipation (rome iv criteria and the bristol scale), underwent a physical evaluation by a trained professional, and then began the application of the research protocol. the antares brand laser device was used for 3 sessions with an interval of 24 hours. the visual analogue scale (vas) was used before starting treatment, after the first and second sessions, and 1 week after the third session. in addition, at the end of the treatment, the closure, or not, of the lesion was verified, and the questionnaires performed prior to phototherapy were reapplied. the vas assesses the patient's level of pain, which can be divided into mild pain (1-2), moderate pain (3-7), and severe pain (8-10). the bristol scale is based on the identification of the patient's consistency of stools, while types 1-2 correspond to constipation, 3-4 indicate normal intestinal rhythm, 5 indicate lack of fiber, and 6-7 correspond to diarrhea.


Eligibility criteria:
inclusion criteria: * individuals with the diagnosis of anal fissure that accepted to participate as volunteers in the clinical trial exclusion criteria: * individuals with pelvic inflammation * individuals who have been through surgical procedures * individuals who have relapse

Keywords: fissure ano phototherapy
trial for quantity-effect relationship of acupuncture with two-ways regulation to treat functional enteropathy

Conditions: Functional Constipation; Functional Diarrhea

Summary: the objective of this study is to investigate the dose-effect relationship of acupuncture with two-ways regulation effect to treat functional enteropathy

eligibility criteria: functional constipation,functional diarrhea，irritable bowel syndrome

Eligibility criteria:
inclusion criteria: * function constipation function diarrhea exclusion criteria: * not function constipation not function diarrhea

Keywords: functional constipation functional diarrhea acupuncture
burden of obstructive sleep apnea in stroke (bosast)

Conditions: Stroke; Obstructive Sleep Apnea

Summary: there are two purposes of this study. the first purpose is to define the frequency of obstructive sleep apnea in stroke survivors as well as its association with fatigue and quality of life. the second purpose is to determine if continuous positive airways pressure (cpap) treatment can have a beneficial effect on these patients' fatigue and quality of life.

stroke survivors frequently complain of fatigue, depressive symptoms, and decreased cognitive functioning. these burdens complicate the recovery and rehabilitation from stroke. while there may be many contributing factors to these burdens, one factor in particular may be both terribly common and yet readily susceptible to intervention. consistent reports from around the world demonstrate that \>50% of stroke patients have obstructive sleep apnea (osa), a disorder that is also associated with fatigue, depressive symptoms, and decreased cognitive functioning. osa is also associated with increases in inflammatory products which themselves are associated with the same array of burdens. this study will examine inpatients at a stroke rehabilitation center. patients' sleep will be studied. patients with osa will be randomized to 10 days treatment double blind with either continuous positive airways pressure (cpap) treatment or to sub-therapeutic cpap treatment. after 10 days of treatment, the osa patients and the stroke patient without osa will be restudied. the study will shed light on the impact of osa on stroke patients' burdens.

Eligibility criteria:
inclusion criteria: * stroke survivor in stroke rehabilitation unit * age 45-85 * able to consent * no prior treatment with cpap exclusion criteria: * complex apnea * known inflammatory disease * neurological disease precluding patient's ability to consent and cooperate

Keywords: stroke obstructive sleep apnea fatigue quality of life
validation of indicor photoplethysmography (ppg) valsalva pulse response vs non-invasive blood pressure

Conditions: Heart Failure

Summary: this study designed is compare the pulse response to the valsalva maneuver between a photoplethysmography sensor (ppg) and non-invasive blood pressure sensor for the purpose of validating the ppg methodology in deriving a value for the valsalva pulse response. the aim is to show that the ppg method captures the same phase responses as the blood pressure monitor and the primary outcome is the correlation between pulse amplitude ratios for the pulse at the end of the valsalva to an average baseline pulse.

with both a photoplethysmography (ppg; indicor, vixiar medical,. baltimore, md) and non-invasive blood pressure (caretaker, caretaker medical, charlottesville, va) sensors in place on the index and middle fingers, respectively, each patient will be asked to perform three mild, 10-sec valsalva maneuvers with at least 45 seconds between. pulse recordings will be collected from each device to compare phases of the valsalva pulse response including pulse amplitude changes and baseline movement. the primary outcome is the correlation between pulse amplitude ratios for the pulse at the end of the valsalva to an average baseline pulse.

Eligibility criteria:
inclusion criteria: * clinically stable adults, including heart failure patients visiting an outpatient clinic exclusion criteria: * atrial flutter or atrial fibrillation with an irregular ventricular response * significant atrial or ventricular ectopy * history of paradoxical emboli * hypertrophic obstructive cardiomyopathy * known intracardiac shunt * known severe aortic valve stenosis * known severe mitral valve stenosis * history of embolic cva * myocardial infarction within one week of intended indicor testing * uncontrolled hypertension (systolic bp \>160mmhg or diastolic bp\>100mmhg) * hypotension (systolic bp \<90mmhg) * symptomatic bradycardia * known cholesterol emboli * poor left ventricular function with left ventricular thrombus * unstable angina * significant aortic valvular disease * patients weighing less than 40kg
activity and fatigue of the respiratory muscles and pulmonary characteristics in post-polio patients

Conditions: Post-polio Syndrome

Summary: background: early diagnosis of respiratory impairment in post-polio (pps) patients may delay respiratory decline and future need of invasive respiratory aids. objectives: to compare pulmonary function measures, maximal respiratory pressure and activity levels and fatigue of respiratory muscles between patients with pps and healthy controls. design: cross-sectional study. setting: hadassah physical medicine and rehabilitation department, jerusalem. patients: patients with pps (n=12; 6 males; age 62.1±11.6 years) able to walk for 6 minutes without human assistance; age-matched healthy subjects (n=12; 4 males; age 62.2±6.5 years). intervention: none. measurements: a body plethysmograph was used to quantify forced expiratory volume in the first second of a forced expiratory maneuver, vital capacity, slow vital capacity, residual volume (rv), total lung capacity (tlc), and thoracic gas volume (tgv). also, rv to tlc ratio is calculated. a manometer was used to measure maximal inspiratory pressure (mip) and maximal expiratory pressure (mep). a spirometer was used to measure maximal voluntary ventilation (mvv). surface electromyography (semg) recorded diaphragmatic muscle activity during rest and while performing mvv.


Eligibility criteria:
inclusion criteria: * diagnosed with post-polio syndrome * able to walk for 6 minutes, with or without walking aids and orthotics but without human assistance exclusion criteria: * any neurological or orthopedic condition, unrelated to post-polio syndrome
acute comfort and blur profile of a lubricant eye drop versus a marketed lubricant eye gel

Conditions: Dry Eye

Summary: the purpose of this study is to compare the comfort and blurriness of an investigational lubricant eye drop with a marketed lubricant eye gel.


Eligibility criteria:
inclusion criteria: * documented diagnosis of dry eye exclusion criteria: * must not have worn contact lenses within 12 hours preceding enrollment * must not have used any topical ocular drops or ointment within 24 hours preceding enrollment

Keywords: dry eye artificial tears
vascular thrombus involvement in nephroblastoma

Conditions: Nephroblastoma with Vena Cava Thrombosis

Summary: nephroblastoma (wilms tumor) is the most common kidney tumor in children. it is a malignant embryonic tumor with a good prognosis with more than 85% long-term survival with appropriate chemotherapy, surgery (which most often consists of a total nephrectomy) and radiotherapy for locally invasive forms. some nephroblastomas (approximately 10%) present with vascular extension with vena cava thrombus, a situation which may worsen the prognosis due to the complexity of the surgery. while the oncological treatment of nephroblastoma is highly formalized, to date there is no specific guideline on the surgical management of this rare clinical presentation of nephroblastomas. the aim of the study is to provide recommendations for the surgical management of nephroblastomas with vena cava thrombus in a large multicenter series.

nephroblastoma (wilms tumor) is the most common kidney tumor in children. it is a malignant embryonic tumor with a good prognosis with more than 85% long-term survival with appropriate chemotherapy, surgery (which most often consists of a total nephrectomy) and radiotherapy for locally invasive forms. some nephroblastomas (approximately 10%) present with vascular extension with vena cava thrombus, a situation which may worsen the prognosis due to the complexity of the surgery. while the oncological treatment of nephroblastoma is highly formalized, to date there is no specific guideline on the surgical management of this rare clinical presentation of nephroblastomas. the management of children with nephroblastomas with vena cava thrombosis is very specific because of the vital risks to diagnosis, especially pulmonary embolism but also cardiac arrest (in the event of extension in the right atrium) and cerebrovascular accidents by embolism, rarer. surgery of the primary tumor and its intravascular extension is complex and may require the use of extracorporeal circulation, a source of significant morbidity and even mortality. these patients who will actually have a single kidney are at high risk for renal failure due to possible contralateral kidney damage during surgery. surgery is not clearly codified because cases are rare, including in expert centers. the aim of the study is to provide recommendations for the surgical management of nephroblastomas with vena cava thrombus in a large multicenter series.

Eligibility criteria:
inclusion criteria: * minors with nephroblastoma with vena cava thrombosis +/- atrial extension. * cared between 1999 and 2019 in the centers of the study. exclusion criteria: - other renal and non-renal tumors with vena cava thrombosis.

Keywords: nephroblastoma wilms tumor vena cava thrombosis surgical management
prevention of arrhythmia device infection trial (padit pilot)

Conditions: Arrythmias

Summary: the goal of the pilot study is to compare conventional antibiotic therapy to an aggressive antibiotic therapy plan for the prevention of arrhythmia device infection in high-risk patients undergoing arrhythmia device procedures. all antibiotics are approved for use and readily available.

infection can occur after surgery for either a pacemaker or an implantable defibrillation and can have very serious consequences. these infections are common and can be seen in as many as 2-3% of high-risk patients. doctors use antibiotics to prevent these infections, but we do not know how much or how often to give the antibiotics to get the best effect. it is not known whether additional antibiotics during and after the operation would further reduce the risk of infection. this research study will compare two different ways of using common antibiotics to prevent infection during and following a device procedure. one way is the standard approach of a single dose before surgery and the other way uses more antibiotics. we do not know if either way is better. the purpose of this study therefore, is to compare two types of antibiotic therapy plans to better understand if one is most effective in preventing infection. this study will provide the ability to evaluate the feasibility (i.e. site activation, enrollment, compliance, drop-out) and generate proof of concept for the larger clinical trial of 12,000 patients in all 25 canadian hospitals implanting icds, which will be submitted to the cihr. additionally, the study supports the continued initiatives of the network of physician investigators (canadian heart rhythm society device advisory committee - chrs dac) collaborating to address arrhythmia procedures related clinical trials that will answer simple clinical questions that will focus initially on safety issues.

Eligibility criteria:
inclusion criteria: * \> 18 years * one of the following planned device procedures: * icd, pacemaker, crt-p, crt-d generator and/or lead replacement or * pocket or lead revision or * system upgrade (insertion or attempted insertion of leads) or * new cardiac resynchronization therapy device implant (pacemaker or icd) exclusion criteria: * unable or unwilling to provide written informed consent * unable or unwilling to complete the study follow-up schedule * life expectancy \< 12 months as per the opinion if the local investigator * allergy to or unable to tolerate cefazolin or clindamycin or vancomycin * allergy to or unable to tolerate intracavitary bacitracin or gentamicin or cefazolin * previously enrolled in this trial * in another study that would confound the results of this trial

Keywords: device procedure pacemaker icd antibiotics
a study to evaluate the efficacy and safety of mirikizumab (ly3074828) in participants with moderate-to-severe plaque psoriasis

Conditions: Psoriasis

Summary: the purpose of this study is to evaluate the efficacy and safety of mirikizumab in participants with moderate to severe plaque psoriasis.


Eligibility criteria:
inclusion criteria: * present with chronic plaque psoriasis based on an investigator confirmed diagnosis of chronic psoriasis vulgaris for at least 6 months prior to baseline and meet the following criteria: * plaque psoriasis involving ≥10% bsa and absolute pasi score ≥12 in affected skin at screening and baseline * spga score of ≥3 at screening and baseline * candidate for systemic therapy and/or phototherapy for psoriasis. exclusion criteria: * have an unstable or uncontrolled illness, including but not limited to a cerebro-cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematologic, or neurologic disease or abnormal laboratory values at screening, that in the opinion of the investigator, would potentially affect participant safety within the study or of interfering with the interpretation of data. * breastfeeding or nursing women. * have had serious, opportunistic, or chronic/recurring infection within 3 months prior to screening. * have received a bacillus calmette-guerin (bcg) vaccination within 12 months or received live vaccine(s) (including attenuated live vaccines) within 12 weeks of baseline or intend to receive either during the study. * have any other skin conditions (excluding psoriasis) that would affect interpretation of the results. * have received systemic nonbiologic psoriasis therapy or phototherapy within 28 days prior to baseline. * have received topical psoriasis treatment within 14 days prior to baseline. * have received anti-tumor necrosis factor (tnf) biologics, or anti-interleukin (il)-17 targeting biologics within 12 weeks prior to baseline. * have previous exposure to any biologic therapy targeting il-23 (including ustekinumab), either licensed or investigational.

Keywords: psoriasis il-23
comparison of early whole body vibration and progressive resistance training in fast-track total knee arthroplasty.

Conditions: Knee Arthropathy

Summary: patients who have undergone total knee arthroplasty (tka) with fast-track recovery protocol at the department of orthopedics and traumatology at the local university hospital and meet the inclusion and exclusion criteria will constitute the study sample. the patients will be divided into 2 groups using the computerized randomization method in the post-operative 4th week; whole body vibration group and progressive resistance exercise group. the first evaluation of the participants will be made at the end of the post-operative 4th week. final evaluations will be made at the end of the post-operative 10th week, following the 6-week training.

patients who have undergone total knee arthroplasty (tka) with fast-track recovery protocol at the department of orthopedics and traumatology at the local university hospital and meet the inclusion and exclusion criteria will constitute the study sample. the patients will be divided into 2 groups using the computerized randomization method in the post-operative 4th week; whole body vibration group and progressive resistance exercise group. the first evaluation of the participants will be made at the end of the post-operative 4th week. after 2 days and 6 weeks of training a week, final evaluations will be made at the end of the 10th postoperative week. evaluations will include measures of impairment in body functions and structures, activity limitation measures, balance assessment, and quality of life assessments. evaluations will be made by a blind researcher. the study will be started with a total of 28 patients, including 14 participants in both groups. the sample size was determined by performing a power analysis. the purpose of the study will be explained to the patients by the researcher and the patients who agree to participate in the planned study will be included in the study.

Eligibility criteria:
inclusion criteria: * undergoing unilateral tka surgery due to knee oa, * being between the ages of 50-75, * to be able to understand the verbal and written information given. exclusion criteria: * to undergo revision tka surgery. * participating in any exercise or strengthening training within the last 3 months. * having undergone major surgery on the extremity to be operated on. * having a comorbid disease such as rheumatoid arthritis, cancer. * having a neurological disease that causes functional insufficiency. * having a diagnosed psychiatric disorder. * having received anaesthesia for any reason in the last 1 month. * regularly using hypnotics or anxiolytics. * having dementia. * having a hearing or vision impairment that cannot be corrected with a hearing aid or glasses. * being morbidly obese (body mass index\> 40 kg/m2). * having implanted pacemakers or defibrillators. * having dermatological problems affecting the thigh. * having a score above 3 in the american society of anesthesiologists classification score.

Keywords: fast-track surgery whole body vibration progressive resistance training total knee arthroplasty rehabilitation
water-based zinc intervention trial in zinc deficient children

Conditions: Zinc Deficiency; Diarrhea

Summary: the overall aim of this trial is to determine whether the use of the household-based water treatment device life straw family (lsf) can be an effective strategy to improve zinc status and health status of vulnerable populations in developing country rural settings with poor access to potable water. to assess the effectiveness of the lsf strategy (a filter delivering purified and zinc enriched water) a double blind controlled field efficacy trial will take place over a period of 12 months in rural villages in the district of natitingou, north-west benin. in order to attain the research objectives the efficacy trial will envisage 3 arms: intervention (zinc enriching filter), placebo (filter) and control group (disinfection tables). during the trial the following outcomes will be monitored: zinc status and growth rate of the participating children, zinc status and pregnancy outcome in a sub-sample of pregnant women (pregnancy sub-study), diarrhea prevalence in all participating subjects, water quality, zinc enrichment of water, and modality and consistency of use of the lsf-device by the study population. the study hypotheses are: 1) the use of the lsf-device will reduce microbiological contamination of the household water, 2) the use of the lsf-device will increase zinc intakes and serum zinc concentration in preschool children, 3) the use of the lsf-device will increase zinc intakes and serum zinc concentration in pregnant women, 4) the achievement of 1 and 2 will improve growth and lower frequency and length of diarrhea episodes in participating preschool children, 5) the achievement of 1 and 3 will improve pregnancy outcome and lower frequency and length of diarrhea episodes in participating pregnant women, 6) the use of the lsf-device will lower frequency and length of diarrhea episodes in participating households members.


Eligibility criteria:
inclusion criteria: * 2-5 year old children * subjects residing in the study area for the whole study period exclusion criteria: * subject with severe anemia (hb \< 7 g/dl) * subjects affected by chronic medical illnesses known to interact with zinc metabolism * subjects receiving zinc supplementation or other medicines that may affect zinc metabolism
validating clinical efficacy for integrated psychological intervention for obesity: physical therapy and psychotherapy

Conditions: Mental Health Issue; Body Image

Summary: this study is to develop an integrated therapy (physical therapy and psychotherapy) to treat cognitive distortion for body image. then, validate its efficacy to make an improvement in both physical and mental health.


Eligibility criteria:
inclusion criteria: * bmi 25\~30 * the score over 68 in sims (the situational motivation scale) exclusion criteria: * diagnosed in any chronic disease * trouble using smartphone * pregnant or planning to be pregnant * unable to be in the fmri * limited to be involved in physical activities over 30 minutes * already had an experience in liposuction

Keywords: body image satisfaction liposuction psychological therapy