Kornimate/medical-research-clean huggingface dataset:
art therapy and caregivers stress

Conditions: Caregiver Stress Syndrome

Summary: this research will be conducted to determine the effect of art therapy on the stress, anxiety and well-being of caregivers in the palliative care service.

introduction and aim: evidence for the use of art in health promotion has been increasing in recent years. however, in the literature review, no study was found in our country examining the effect of art therapy on caregivers. in palliative care, the management of psychological problems such as stress and anxiety that caregivers frequently experience is very important for the health and quality of life of both the patient and the caregiver. accordingly, this research will be conducted to determine the effect of art therapy on the stress, anxiety and well-being of caregivers in the palliative care service. methods: the research will be carried out as a randomized controlled experimental study in the palliative care unit of a training and research hospital. a distress thermometer will be applied to individuals who are primary caregivers of patients hospitalized in the palliative care unit, and caregivers with a stress score of 4 and above will be included in the sample. the block randomization method will be used in assigning the individuals included in the sample to the art therapy and control groups. caregivers in the art therapy group will be given art therapy practices, lasting approximately 45 minutes-1 hour, twice a week for 4 weeks. visual and handicraft practices (painting work, collage work, mandala work, painting with felt, clay work, painting and storytelling) are done in art therapy activities that will last for 4 weeks, and it is aimed to develop personal and emotional awareness, reduce stress and increase general well-being. research data will be collected using descriptive information form, distress thermometer, state anxiety inventory and personal well-being scale. conclusions: it is thought that this study will increase attention to art therapy, improve stress and anxiety levels in caregivers, and strengthen current and future research in art therapy and nursing research. given the key role caregivers play in palliative care, it is important to support caregivers as a necessity for holistic and comprehensive health care services

Eligibility criteria:
inclusion criteria: * the age of 18 and over, * must be able to read and speak turkish * care givers of patients hospitalized in palliative care clinics, * has a distress score of 4 or above, * does not have any sensory or cognitive health problems that would prevent communication, * must agree to participate in the study exclusion criteria: * no primary caregiver role * has a physical disability to perform artistic practices,
improving pain management and opioid safety for patients with cirrhosis

Conditions: Cirrhosis, Liver

Summary: this project aims to test a behavioral intervention in patients with liver cirrhosis and chronic pain and teach self pain-management skills.

prescription opioid medications are a leading cause of opioid-related death and are particularly risky in patients with cirrhosis of the liver, which affects 4 million people in the us. in this population, prescription opioids are associated with complications of liver disease, decreased access to life-saving transplantation, and increased hospitalization, post-transplant mortality, and all-cause mortality. moreover, most patients with cirrhosis have underlying alcohol and/or substance use disorders (suds), which increase the risk of opioid-related complications and misuse. despite these risks, our pilot work found that nearly half of all patients with cirrhosis are prescribed opioid medications each year and that these prescriptions are often inconsistent with opioid prescribing safety guidelines. one potential reason for this may be the lack of safe, evidence-based, alternative pain management strategies for this patient population. indeed, existing opioid safety and pain management interventions designed for general populations do not address many of the specific issues facing patients with cirrhosis. the research team plans to recruit patients at upmc for participation in the liver education about pain (leap) intervention program. leap is a modular 12-week pain self-management intervention with individual and group sessions. individual sessions serve the purpose of individualizing the program to the needs of the patients. group sessions allow participants to practice skills, set goals with the group, seek social support, and learn together. the purpose of the leap program is to make pain better, help patients reach their personal goals (things that may be hard to do because of pain), and add to the care patients' medical team is providing.

Eligibility criteria:
inclusion criteria: * all participants must be over 18 years of age and fluent in english * must have a diagnosis of cirrhosis * must be receiving care at upmc hepatology clinics * must have chronic pain lasting at least 3 months exclusion criteria: * participants will be excluded if they are younger than 18 years of age or are unable to provide informed consent for any reason * participants will be excluded if they had a prior liver transplantation or have a limited life expectancy of less than 6 months

Keywords: liver diseases cirrhosis, liver implementation science strategies evaluation behavioral intervention
a study of contrast-enhanced mammography (cem) scans in people with breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study is to find out whether contrast-enhanced mammography/cem scans performed 2 minutes and 6 minutes after receiving iohexol contrast dye can be used to identify the amount of residual disease in the breast following neoadjuvant treatment.


Eligibility criteria:
inclusion criteria: * any women \>18 years of age at time of informed consent * diagnosed with breast cancer and schedule for nat exclusion criteria: * history of kidney disease, creatinine level \>1.3 or egfr \<45. * known allergic reaction to gadolinium or iodinated contrast media. * contraindication to contrast-enhanced breast mri. * lesion not included in the field of view of either pre- or post-nat mri or cem * presence of pacemakers or automated implantable cardioverter defibrilator * pregnant women

Keywords: breast cancer memorial sloan kettering cancer center 23-224
clinical application of autologous three-cellular cultured skin substitutes (css)

Conditions: Burns; Ulcers; Giant Nevi

Summary: the aim of this work was to present the investigators experience in the use of autologous three-cellular cultured skin substitutes (css) consisting of cultured keratinocytes, melanocytes and fibroblasts attached to a scaffold of hyaluronic acid. this method represents a surgical alternative in the treatment of a variety of pathologies, including burns, ulcers and giant nevi.

background and objective: permanent wound closure remains a limiting factor in the closure of extensive, full-thickness loss of substance. the aim of this work was to present our experience in the use of autologous three-cellular cultured skin substitutes (css) consisting of cultured keratinocytes, melanocytes and fibroblasts attached to a scaffold of hyaluronic acid. this method represents a surgical alternative in the treatment of a variety of pathologies, including burns, ulcers and giant nevi. methods: css were obtained from full-thickness skin biopsies collected after enrollment of 11 patients in a study protocol approved by the local institutional review boards of the "la sapienza" university of rome. css consisted of a structure characterized by the presence of a pluristratified epithelial cell surface with melanocytes (relation 1/20) and a basement of fibroblasts kept together by an esterified hyaluronic acid scaffold that can be surgically manipulated, and is gradually reabsorbed after implantation and substituted by the host connectival stroma.

Eligibility criteria:
inclusion criteria: * of extensive full-thickness loss of substance exclusion criteria: * location: face * all contra indications for surgery * coagulation disorders * infection * allergic reactions * collagenopathies * malignant cancer and chemotherapy * immunodeficiencies * diabetes

Keywords: bioengineered ski keratinocytes fibroblasts skin culture autologous css full-thickness loss of substance from: burns ulcers giant nevi cicatricial outcomes
circulating tumour dna (ctdna) in patients with colorectal cancer and the relationship to imaging features of extramural venous invasion

Conditions: Cancer; Rectal Cancer

Summary: this study does not involve randomization or treatment. eligible patients have colorectal adenocarcinoma with no metastases eligible for curative surgery. a pre operative staging scan must have been completed within 6 weeks prior to surgery. two x 20ml blood samples will be taken from each patient, one prior to and one during or within 24hrs after surgery. patients are annually followed up to 3 years.

a multicentre observational study, ctdna aims to provide the evidence base for metatstatic disease being caused by vascular methods of spread by determining if there is a link between emvi status and ctdna

Eligibility criteria:
inclusion criteria: 1. have a biopsy-confirmed colorectal adenocarcinoma 2. is eligible for curative surgery 3. has no metastatic disease on ct scan 4. has completed pre-operative staging scan within six weeks prior to surgery 5. have provided written informed consent to participate in the study 6. be aged 16 years or over exclusion criteria: 1. have metastatic disease (including resectable liver metastases) 2. have a synchronous second malignancy 3. are contraindicated for any imaging able to determine emvi status

Keywords: emvi extramural venous invasion mremvi rectal cancer ctdna neoplasm dna mri
determination of anatomic variations of the internal jugular and femoral veins using ultrasound in the emergency department

Conditions: Vascular Anatomy

Summary: central venous catheterization is a common and important procedure done in the emergency department. the internal jugular vein (ijv), subclavian vein (sv) and femoral vein (fv) are commonly used for central venous access. unfortunately, this procedure has high-risk complications. traditionally, physicians have relied on the use of anatomic landmarks and physical manipulation such as moving the head or rotating the leg in order to place central catheters; however, studies have demonstrated that significant anatomic variations exist within large percentages of study populations. in addition, although studies have demonstrated that the use of ultrasonography for placement of femoral catheters leads to lower rates of complications, no previous studies have specifically determined anatomic variations in the femoral triangle. therefore, this study will examine the anatomic variation of the ijv vs. carotid artery and the femoral vein vs. femoral artery in the emergency room setting. the investigators will study the variation as a function of sex, age, race, body habitus and degree of head rotation (measured using a goniometer) and in doing so, the investigators will demonstrate the utility of using ultrasound to place central lines in order to decrease morbidity.


Eligibility criteria:
inclusion criteria: * patients being cared for in the tampa general hospital emergency department * 18 yrs or older * male or female * have the anatomy that will be examined (lateral neck and femoral regions) * speak either english or spanish * alert and oriented to person, place, time and situation * stable vital signs exclusion criteria: * under 18 yrs * incarcerated individuals * those with acute changes in mental status (intoxicated, encephalopathy, psychosis) * those from whom consent could not be obtained * those requiring intensive care monitoring * persons having pathologies that would interfere with the ultrasound investigation * persons who do not speak english or spanish * persons with acute or severe mental or cognitive disabilities * individuals in a sedated, traumatized or crisis state

Keywords: ultrasound femoral vein internal jugular vein
characteristics and outcomes of odontoid fragility fractures in elderly

Conditions: Odontoid Fracture; Osteoporosis; Surgery

Summary: usually, cervical spine fractures are not considered as osteoporotic fractures. however, recent studies show that odontoid fractures are the most common fractures of the cervical spine in elderly and may occur in a context of low trauma energy. thus, the goal of this observationnal study is : * to describe the different type of odontoid fracture and to characterize bone status in elderly patient (\>65 y) who underwent odontoid fracture in a context of low trauma energy. * to describe short and long term outcomes

all patients over 65 y admitted for low trauma odontoid fracture will be consecutively included in the study after informed consent. the investigators will record: * clinical risk factor of osteoporosis and health habits including accomodation * type of fracture and characterization of the odontoid fracture on imaging (standard x ray / mri / qct) * bone status : bone mineral density on dxa, lab tests for secondary osteoporosis check-up, previous vertebral fracture on vfa or x ray * osteoporosis managment : nutrition, vitamin d, anti-osteoporotic drugs * treatment of the fracture : surgical / non surgical * adverse event during hospitalization * lenght of hospital stay * type of discharge follow-up à 3 and 12 months : dead vs alive ; accomodation ; autonomy ; new fracture

Eligibility criteria:
inclusion criteria: * all patients over 65 y admitted for low traumat odontoid fracture exclusion criteria: * patient \< 65 y * traumatic odontoid fracture
effect of qmix 2in1 as final irrigation protocol on periapical healing

Conditions: Periapical Diseases

Summary: aim: to compare the 12-month radiographic outcome of root canal treatment with and without the additional use of qmix 2-in-1 (dentsply tulsa, maillefer, ballaigues, switzerland) irrigation solution. methodology: the study included 60 single-rooted teeth with periapical radiolucency of 60 patients, randomized into two groups using randomized block design with block sizes of 10 patients in each. root canals were prepared with waveone gold files (dentsply sirona, maillefer, ballaigues, switzerland) and irrigation was performed with 5 ml 2.5% sodium hypochlorite (naocl) using side-vented needles during instrumentation. the final irrigation protocol was performed using 5 ml 2.5% naocl (n= 30) or 5 ml qmix 2-in-1 (n=30). then the root canals were irrigated with 5 ml of distilled water and filled with gutta-percha and ah plus sealer (dentsply sirona), using the cold lateral compaction technique. the patients were recalled after 12 months and evaluated radiographically according to perapical index (pai) scores. pre and post-treatment pai scores were compared and teeth were considered 'healthy' (pai ≤ 2) or 'diseased' (pai ≥ 3). the mann whitney u test was used to compare the differences between the post-operative and follow-up images of the treatment groups. the wilcoxon signed rank test was applied to examine the changes in pai score from baseline to the follow-up evaluation in each group.

this randomized controlled trial was conducted to evaluate radiographic periapical repair after endodontic treatment using qmix 2-in-1 (dentsply tulsa, maillefer, ballaigues, switzerland) and naocl irrigation in single-rooted teeth with apical periodontitis.

Eligibility criteria:
inclusion criteria: * necrotic, single root teeth with a periapical lesion (2\>pai\>5) exclusion criteria: * pregnant * had used antibiotics within the previous week * allergy to local anesthetic agents * history of intolerance to non-steroidal anti-inflammatory drugs * had uncontrolled hypertension, uncontrolled diabetes mellitus, chronic renal failure, hematological disease, or had received or were receiving radiotherapy and periodontal bone loss (visualized radiographically) * open tooth apex

Keywords: qmix 2-in-1 sodium hypochlorite chlorhexidine treatment outcome radiographic healing
biological evaluation of a novel anti-inflammatory treatment in immune-mediated inflammatory diseases

Conditions: Inflammation

Summary: the aim of the study is to investigate in vitro the impact of a novel anti-inflammatory treatment on costimulatory molecules expressed on monocytes.


Eligibility criteria:
inclusion criteria: * immune-mediated inflammatory disease (non-st segment elevation myocardial infarction, rheumatoid arthritis, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, crohn's disease, ulcerative colitis, cystic fibrosis, psoriasis, multiple sclerosis or major depressive episode) * patient able to understand the reason of the study * patient not opposed to the conservation of biological samples for scientific research exclusion criteria: * pregnant woman * subject without health insurance

Keywords: immunomodulation
the effect of the cytosorb® filter to remove anticoagulants from the circulation during emergency surgery for aortic dissection

Conditions: Aortic Dissection; Factor X Inhibition

Summary: the direct oral anticoagulants (doacs) and particularly the fxa inhibitors are a concern in patients presenting with type a aortic dissection as this may contribute to severe bleeding complications. the antidote andexanet alfa (ondexxya®) can interact with the heparin- anti-thrombin iii (atiii) complex which may neutralize the anticoagulant effect of heparin and the use of andexanet alfa before surgery necessitating heparin-anticoagulation has been reported to cause unresponsiveness to heparin. the investigators have preliminary in-vitro data demonstrating the ability to remove apixaban from reconstituted blod by hemadsorption and are now analyzing if afxa inhibitor levels may be reduced by hemadsorption in the clinical setting analyzing this in patients using fxa inhibitors being operated acutely for type a aortic dissection.


Eligibility criteria:
inclusion criteria: * indication for urgent surgery for proximal aortic disease * treatment with fxa inhibitor for more than 2 weeks * measured concentration of fxa inhibitor in therapeutic range (\>50 ng/ml) at the time of admission. * intraoperative use of cytosorb® hemadsorber. exclusion criteria: • low fxa inhibitor concentration (\<50 ng/ml) at the time of admission
assessment of gastrointestinal blood loss after receiving aspirin or aspirin plus rivaroxaban, or aspirin plus regn9933, or aspirin plus regn7508 in healthy adult participants

Conditions: Healthy Volunteers

Summary: this study is researching experimental drugs called regn9933 and regn7508 (called "study drugs") and comparing their effects to approved treatments of rivaroxaban and aspirin (called "standard treatments"). aspirin will be given alone or in combination with the study drugs or the other standard treatments to look at their effects on blood loss in the intestines. the aim of the study is to see if aspirin alone or the study drugs regn9933 and regn7508, when taken with aspirin, cause less minor intestinal bleeding than standard treatments rivaroxaban with aspirin. the study is looking at several other research questions, including: * what side effects may happen from taking the study drug * how much study drug is in the blood at different times * whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)


Eligibility criteria:
key inclusion criteria: 1. body mass index between 18.0 and 32.5 kg/m2 (inclusive) at the screening visit 2. judged by the investigator to be in good health based on medical history, physical examination, vital sign measurements, and electrocardiograms (ecgs) performed at screening and/or prior to administration of initial dose of study treatment 3. normal aptt, normal pt, and normal platelet counts at screening period and at the day 1 visit as defined by the local laboratory 4. hemoglobin values within the normal range, per local laboratory, at the screening and day 1 visits 5. negative fobt at baseline (visit 2) and visit 3 as defined in the protocol key exclusion criteria: 1. history of any major surgical procedure or clinically significant physical trauma in the last 6 months, in the opinion of the investigator, that may pose a risk to the participant by study participation 2. whole blood donation within the previous 56 days or plasma donation within the previous 7 days prior to the screening visit 3. hospitalized for any reason within 30 days of the screening visit 4. estimated glomerular filtrate rate (egfr) of \<60 ml/min/1.73m2 at screening as described in the protocol. 5. current smoker or former smoker, including e-cigarettes, who stopped smoking within 12 months prior to the screening visit 6. history of illicit drug or alcohol abuse within the last 2 years prior to the day 1 visit 7. use of any prescription and nonprescription medications or nutritional supplements from approximately 2 weeks or 5 half-lives, as described in protocol 8. has elective surgery planned to occur prior to end of study (eos) note: other protocol defined inclusion/ exclusion criteria apply

Keywords: gastrointestinal (gi) bleeding fecal occult blood testing (fobt)
travelling in patients with sleep related breathing disorders

Conditions: Travel, Sleep Related Disorder

Summary: one questionnaire has been configured to ask therapy naive and treated patients about their travel activities. travel activities include private and professional traveling. another questionnaire collects medical information.

including a german sleep committee a new questionnaire has been created to ask patients about their travel habits. only travels over a onenightstay were of interest. all detailed information about the destination has been asked. a special point of interest were the impacts of traveling. for each patient a doctor completed the medical history including sleep related breathing disorder and relevant medical conditions e.g. orthopedic impacts.

Eligibility criteria:
inclusion criteria: * patients with sleep related breathing disorder * informed consent provided exclusion criteria: * patients with no sleep related breathing disorder * no informed consent provided
pulmonary embolism and covid-19

Conditions: Covid-19; Pulmonary Embolism

Summary: the charts of patients who developed pulmonary embolism in the course of covid-19 will be evaluated, retrospectively. clinical features and laboratory data will be analyzed.

patients with covid-19 infection will be evaluated retrospectively. demographic data, clinical and laboratory findings will be recorded. findings of patients with pulmonary embolism and withour pulmonary embolism will be compared.

Eligibility criteria:
inclusion criteria: - all patients with positive rt-pcr for covid-19 exclusion criteria: - all patients with negative rt-pcr for covid-19