Kornimate/medical-research-clean huggingface dataset:
study of surgically-induced weight loss on pelvic floor disorders

Conditions: Pelvic Floor Disorders

Summary: the specific aim of this study is to evaluate the effect of surgically-induced weight reduction, as achieved by laparoscopic gastric banding or sleeve gastrectomy, on pelvic floor disorders such as stress urinary incontinence, overactive bladder, anal incontinence, and pelvic organ prolapse in severely, morbidly and super-obese women using a prospective, observational study design.


Eligibility criteria:
inclusion criteria: * surgical eligibility met by center for the treatment obesity criteria * morbid obesity (bmi \> 40 kg/m2) or severe obesity (bmi \> 33 kg/m2) in presence of nih co-morbidities * willing to participate in study, including completion of self-reported questionnaires exclusion criteria: * pregnancy or planned pregnancy * recent pregnancy or pelvic surgery * age \< 21 years * known neurologic disease or pelvic pathology

Keywords: pelvic floor disorders weight loss
modulation of inflammation by medium cut off membranes

Conditions: Cardiovascular Diseases; End Stage Renal Disease

Summary: this study examines whether medium-cut off dialysis results in improved blood purification of large middle molecules e.g. inflammatory molecules compared to hemodialysis (hd) treatments with conventional high-flux dialyzers.

cardiovascular events and sepsis remain the leading causes of mortality in patients on maintenance hemodialysis. thus expectancy of life for these patients is comparable to the prognosis of metastasized cancer. so far the exact mechanisms causing excess mortality in hemodialysis patients remain elusive, but chronic inflammation seems to play a central role in the pathogenesis of cardiovascular disease in hd patients. keeping this in mind the theranova medium-cut off membrane, with its ability to clear middle molecules (0,5-50 kda), seems suitable to further improve clearance of inflammatory mediators as the non-protein bound inflammatory mediators lie within the cut off range of this membrane. the investigators designed this study to get information on the changes in the inflammatory milieu in dialysis patients when using medium-cut off membranes which are know to significantly reduce cytokines compared to standard high-flux dialyzers.

Eligibility criteria:
inclusion criteria: * time since initiation of dialysis \> 3 months * age \> 18 years exclusion criteria: * time since initiation of dialysis \< 3 months * age \< 18 years * ongoing acute or chronic infection/malignoma, because this will interfere with inflammatory baseline values * major surgery less than 2 weeks before inclusion in the study * pregnancy * mental illness * lack of written and informed consent
exercise effects in children with attention deficit hyperactivity disorder

Conditions: Attention Deficit/Hyperactivity Disorder

Summary: the study will investigate catecholamines responses, and cognitive effects of exercise in children with attention deficit hyperactivity disorder, and the effect of exercise training on these measures.

a leading pathophysiologic hypothesis of attention-deficit/hyperactivity disorder (adhd) is based on the notion of a catecholamine \[ca; norepinephrine (ne), epinephrine (epi), and dopamine (da)\] dysfunction. this hypothesis suggests that the ca response to environmental stimuli is attenuated in adhd and is derived primarily from observations that drugs such as methylphenidate and amphetamine - considered to be ca agonists - are effective in treating the symptoms of adhd. despite this compelling evidence, a definitive role of ca responsiveness in adhd remains controversial. physical activity is widely known to be a powerful stimulus of the hypothalamic-pituitary-adrenal (hpa) and noradrenergic systems. on the basis of the nation of a ca dysfunction in adhd, we reasoned that the normal robust increase in circulating ca seen in response to exercise would be blunted in children with adhd. the objective of this study is to examine the possibility that exercise program and testing might be useful in differentiating ca responses to stress between children who had received a diagnosis of attention-deficit/hyperactivity disorder (adhd) and age- and gender-matched controls. this study will take place in 'children and adolescence health and sports center' in meir medical center, kfar-saba, israel. forty-five children, boys and girls between the ages 6 and 18, with newly diagnosed adhd that not receiving any drugs will be assigned to the intervention group. age and gender matched children with adhd, receiving ritalin and not engaged in regular exercise, or healthy children's without adhd will serve as controls. the intervention group will participate in an exercise program, including aerobic and anaerobic components, twice a week, for 3 months. exercise testing, blood sampling and cognitive assessment will be performed at the start and in the end of this study.

Eligibility criteria:
inclusion criteria: * boys and girls between the ages 6 and 18, with newly diagnosed adhd. exclusion criteria: * children with adhd on medications

Keywords: attention deficit hyperactivity disorder catecholamine children physical activity
a six-month study to compare outcome differences and visceral response ... irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: the purpose of this study is to assess the effect of participation in one of the following interventions: (1) ibs stress management; (2) ibs symptom management; or (3) ibs educational training on improving ibs associated symptoms. it is anticipated that this research will provide information on the usefulness of psychological approaches in treating ibs and will help scientists better understand the disorder.


Eligibility criteria:
inclusion criteria: * irritable bowel syndrome exclusion criteria: * gi pathology (organic disease) that affects bowel transit * co-morbid pain disorders * current or recent history (within 24 months) of drug or alcohol abuse * clinical evidence (including physical exam, laboratory tests) of significant medical disease that may interfere with the patient successfully completing the trial * planned use of drugs or agents that affect gi motility and/or perception

Keywords: irritable bowel syndrome abdominal pain abdominal discomfort diarrhea constipation ibs
reducing sexual risk behaviors and improving health for people at a sexually transmitted infection clinic

Conditions: HIV; Sexually Transmitted Diseases; HIV Infections

Summary: this study will determine whether showing an educational dvd to people at sexually transmitted infection clinics can reduce incidence of new infections and risky sexual behaviors and improve overall health.

sexually transmitted infections (stis) can produce long-term health problems. they are often linked to hiv, which can also be sexually transmitted, because both occur in the same populations and because stis and hiv interact biologically. having an sti other than hiv can increase the risk of hiv acquisition and transmission as well as negatively impact hiv progression. the population of people who go to clinics specializing in stis are particularly at risk of engaging in risky sexual behaviors and having poor health outcomes-like infection with an sti. this study will test the effectiveness of using an educational dvd to reduce incidence of risky sexual behaviors and sti acquisition, including risk of hiv, and to improve overall health. participation in this study will involve two phases. in phase 1, participants will complete both computerized and paper surveys and watch an educational dvd. the educational dvd may include information on diet, physical activity, sleep, smoking, stis, and stress. participants will be recruited from among people who are already going to the clinic, and participation will add approximately 1.5 hours to their visits. in phase 2, participants will be asked to complete four follow-up visits occurring 3, 6, 9, and 12 months after phase 1. during these follow-up visits, participants will complete a 45-minute computerized survey similar to that in phase 1 and provide urine and throat samples for sti testing. all surveys will assess health-related thoughts, feelings, and behaviors, including sexual behaviors. participants will be compensated for completing phase 1 and each visit in phase 2.

Eligibility criteria:
inclusion criteria: * evidence of sexual risk behavior, defined as either signs, symptoms, or diagnosis indicative of an std during the past 3 months; or unprotected vaginal or anal intercourse with two or more sexual partners, a partner with two or more partners, an anonymous partner, an injection drug using partner, or a partner with an std exclusion criteria: * impaired mental status that would prevent participant from providing informed consent or participating meaningfully * inability to understand english

Keywords: std sti sexual behavior prevention hiv seronegativity
the effect of interpersonal psychotherapy on quality of life among people living with hivaids

Conditions: Breif Description: Patients' Quality of Life of

Summary: quality of life (qol) is a significant importance for people living with hiv/aids by modifying the adverse psychosocial consequences that accompany the disease. in ethiopia, interpersonal psychotherapy (ipt) has never been tried for people living with hiv/aids for quality of life. the objective of the study was to assess the effects of interpersonal psychotherapy on quality of life among plwha at mettu karl referral and bedele hospital, southwest ethiopia, 2022.


Eligibility criteria:
inclusion criteria: * plwha who were 18 years of age or above were included in the study exclusion criteria: * plwha who are either currently or previously used ipt and acute physical or mental disturbances will be excluded
expression analysis of urinary exosome in type 2 diabetic kidney disease and evaluation of its clinical diagnostic value

Conditions: Diabetic Nephropathy

Summary: expression analysis of urinary exosome mir-136-5p in type 2 diabetic nephropathy and evaluation of its clinical diagnostic value

1. preliminary screening of mirnas: through geo database and reading related literature, mirnas differentially expressed in type 2 diabetes and diabetic nephropathy were selected as potential candidate biomarkers for follow-up verification. 2. collection and treatment of clinical samples: urine of diabetic patients was collected from the first affiliated hospital of shandong first medical university in strict accordance with the drainage standard, and the basic information of patients was registered. meanwhile, the collected samples were divided into type 2 diabetes group and diabetic nephropathy group according to whether the urine was accompanied by uacr≥300/g. subsequently, the collected samples were centrifuged and retained for supernatant. 3. isolation and identification of urinary exosomes: ultrafast centrifugation method was used to separate the treated urine samples of exosomes, and then identified by transmission electron microscopy, nanoparticle analysis and western blot respectively. 4. real-time pcr was used to detect the changes in urinary exosomal mirna expression levels of the two groups of patients, and statistical analysis and correlation analysis of clinical indicators of the differentially expressed mirnas were performed. 5. target gene prediction and enrichment pathway analysis of differentially expressed mirnas were performed to screen out pathways that might be related to the occurrence and development of dkd, and then the relevant pathways were verified by immunofluorescence, immunocoprecipitate, western blot, real- time pcr and other methods.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years old; 2. previously diagnosed with type 2 diabetes; 3. typical diabetic symptoms (polydipsia, polydipsia, polyuria and weight loss) plus random blood glucose ≥11.1mmol/l; 4. fasting blood glucose ≥7.0mmol/l, fasting is defined as at least 8 hours without intake of calories; 5. oral glucose tolerance test (ogtt) 2-hour blood glucose ≥11.1mmol/ l, using a glucose load equivalent to 75 grams of anhydrous glucose dissolved in water (venous blood was drawn in all patients; 6. with or without uacr≥300mg/g. exclusion criteria: 1. refused to enroll patients; 2. type 1 diabetic nephropathy and other special types of diabetic nephropathy; 3.patients with kidney stones and urinary system infection; 4.patients with autoimmune system diseases, malignant tumors, and blood system diseases; 5.patients with severe chronic cardiopulmonary disease, chronic liver and kidney disease; 6.patients with severe infectious diseases; #7#use of glucocorticoids, immunosuppressants or cytotoxic drugs.
prospective registry of patients with pancreas adenocarcinoma resectable and borderline

Conditions: Chemotherapy Effect; Pancreas Cancer

Summary: unlike other types of gastrointestinal tumors, there is controversial evidence of the efficacy of neoadjuvant therapy in patients with borderline and resectable adenocarcinoma (adk) of the pancreas, the objective of this study is to perform a "snapshot" of the usual practice in our setting in terms of neoadjuvant therapy in adk, both in terms of the different regimens used as well as the results in terms of morbidity, mortality and survival. likewise, in a second phase, a prospective registry of patients included in the neoadjuvant regimen for both resectable and borderline adk diagnosed in catalonia will be launched, which will provide us with valuable information to try to answer open questions in the context of borderline and resectable adk treatment.


Eligibility criteria:
inclusion criteria: * resectable or borderline pancreas adk * with or without radiotherapy * any type of approach * any type of surgery exclusion criteria: * locally advanced adk * no consent
a study of mometasone furoate metered dose inhaler in children with persistent asthma (p04223)

Conditions: Asthma

Summary: the primary objective of this study is to demonstrate the dose-related efficacy, by evaluating morning (am) lung function at the end of the dosing interval (am pre-dose percent predicted forced expiratory volume in one second \[fev1\]) across 12 weeks of treatment, of three doses (50 mcg, 100 mcg, and 200 mcg) of mometasone furoate (mf) metered dose inhaler (mdi) twice a day (bid) compared with placebo in children 5 to 11 years of age, inclusive, with persistent asthma. the primary hypothesis of this study is that at least one dose of mf mdi bid increases lung function, defined as a significant increase in percent predicted fev1, when compared to placebo.


Eligibility criteria:
inclusion criteria: * diagnosis of asthma of at least 6 months duration. * using an inhaled corticosteroid (ics), either alone or in combination with a long-acting beta-2 agonist (laba), for at least 12 weeks prior to the screening visit and must have been on a stable asthma regimen for at least 2 weeks prior to the screening visit, must not have used oral glucocorticosteroids within 30 days of the screening visit. exclusion criteria: * treated in the emergency room for a severe asthma exacerbation requiring systemic glucocorticosteroid treatment, or hospitalization for management of airway obstruction within 3 months prior to the screening visit. * history of ventilator support for respiratory failure secondary to asthma. * upper or lower respiratory tract infection (viral or bacterial) within the 2 weeks prior to screening and baseline visits. * history of clinically significant renal, hepatic, cardiovascular, metabolic, neurologic, hematologic, ophthalmologic, respiratory, gastrointestinal, cerebrovascular, or other significant medical illness or disorder which, in the judgment of the investigator, could interfere with the study or require treatment that might interfere with the study. specific examples include but are not limited to insulin-dependent diabetes, hypertension, active hepatitis, cardiovascular disease including hypertension, or conditions that may interfere with respiratory function such as, bronchiectasis, and cystic fibrosis. other conditions that are well controlled and stable will not prohibit participation if deemed appropriate per the investigator's judgment. * inability to correctly use an oral mdi or a dpi. * participation in this study at another investigational site. participation in a different investigational study at any site during the same time frame of this study. * randomization into this study more than once. * direct association with either the administration of the this study or the study staff.

Keywords: asthma children persistent
clinical study to establish the feasibility and usability of the endorings™

Conditions: Colon Cancer; Bowel Cancer; Colorectal Cancer

Summary: the purpose of this prospective clinical study is to establish the feasibility and usability of the endorings™ when used during standard colonoscopy procedure.

the endoaid ltd. endorings is used during endoscopy procedures. the endorings is a short silicon rubber tube with flexible circular wings that attaches to the distal end of the endoscope to facilitate endoscopic therapy. the endorings is designed to fit specific endoscopes (as designated on the packaging), and is supplied sterile following eto sterilization and is single use only. indications for use: to be attached to the distal end of the endoscope to facilitate endoscopic therapy, to be used for the following: * keeping the suitable depth of endoscope's view field * helping the endoscope with being inserted into the gastrointestinal tract patient population: the study population is comprised of patients indicated for colonoscopy. study design: single-center study. a single treatment group of 60 patients. no. of patients: up to sixty (60) treated patients will be enrolled in the study. primary endpoints:the primary endpoint is reaching the cecum of the colon with the endorings™. secondary endpoints / other outcomes: 1. incidence of complications (number of complications) 2. ability to complete s therapeutic interventions as biopsies, polypectomies, apc etc. 3. procedure time. 4. ease of scope insertion, advancement and withdrawal. 5. ability to center the scope inside the gastrointestinal tract. 6. subjective evaluation of the additional area screened by the physician (recorded in the source documents by a questionnaire). 7. patient satisfactory (by a follow up phone-call in which questionnaire with vas scale will be filled out).

Eligibility criteria:
inclusion criteria: any subject who meets all of the following criteria may be included in this study: * subject between the ages of 18 and 70 * the patient is undergoing colonoscopy for screening, or for surveillance in follow-up of previous polypectomy or for diagnostic workup; * written informed consent must be available before enrollment in the trial * for women with childbearing potential, adequate contraception exclusion criteria: any subject who meets any of the following criteria will not be included in this study: * patients with a history of colonic resection; * patients with inflammatory bowel disease; * patients with a personal history of polyposis syndrome; * patients with suspected chronic stricture potentially precluding complete colonoscopy; * patients with diverticulitis or toxic megacolon; * patients with a history of radiation therapy to abdomen or pelvis; * patients who are currently enrolled in another clinical investigation in which the intervention might compromise the safety of the patient's participation in this study.

Keywords: endorings
whether opioids are factor that induced pod?

Conditions: Postoperative Delirium

Summary: the purpose of this study was to investigate whether perioperative use of low doses of opioids could reduce postoperative delirium .

postoperative delirium (pod) is a common postoperative complication of the elderly caused by a variety of factors. pod is an acute neuropsychiatric disorder characterized by disturbance of attention consciousness and cognitive function fluctuation, and more than 40% of elderly patients have symptoms of hypoactivity pod.the incidence of pod is as high as 17% to 61% in patients with neurocognitive impairment and patients undergoing complex or emergency surgery, which usually occurs between 1 and 3 days after surgery. pod will lead to prolonged hospital stay, functional impairment and even death. how to prevent and treat pod is an urgent clinical problem to be solved at present. opiates are commonly used perioperative sedatives and analgesics, which may be associated with the occurrence of postoperative pod in elderly patients and increase the risk of pod. it is not clear whether perioperative use of low doses of opioids could reduces the incidence of pod in elderly patients. in this study, reducing-opioids anesthesia was defined as the use of 1/3 of the conventional opioid dose to observe whether reducing-opioids anesthesia affected the incidence of pod in elderly patients undergoing gastric cancer surgery

Eligibility criteria:
inclusion criteria: * patients' age ≥65 years * underwent elective radical gastrectomy exclusion criteria: * mini-mental scale test (mmse) exclusion criteria: illiteracy \<18, primary school \<21, junior school and above \<25 * preoperative clear systems and spiritual history of neurological disease or long-term use of sedatives or antidepressants * history of alcohol abuse or a history of drug dependence * have brain surgery or trauma * cannot with the completion of tests of postoperative cognitive dysfunction * refused to participate in the study

Keywords: opioid pod gastric cancer
proton boost for locally advanced head and neck tumors

Conditions: Epithelial Tumor, Malignant; Neuroendocrine Tumors

Summary: the aim of this research project is to test the local response and the acute toxicity (which can be observed within 90 days).

local response and acute toxicity are primary endpoints of the trial. at cnao a proton boost is delivered on the ptv1rx (area at high risk of relapse) up to at least 70 gy \[rbe\] in 2-3 gy \[rbe\] per fractions for 8-15 total fractions. ptv2 rx (area at low or intermediate risk of relapse) will be irradiated with photon imrt up to a total dose of 50-60 gy \[rbe\]. secondary endpoints of the trial are local control, relapse free survival, overall survival, tumor specific survival, intermediate and long term toxicity.

Eligibility criteria:
inclusion criteria: * histologic/cytologic diagnosis of primary epithelial malignant or neuroendocrine tumour * inoperable tumour, locally advanced stage * seated in rhinopharynx, nasal and paranasal sinuses, hypopharynx, larynx, oral cavity and oropharynx * at least one lesion measured according to the recist criteria * enrollment for irradiation with imrt up to 50-60 gy rbe\] on the ptv1rx and ptv2 rx to be followed at cnao with irradiation with proton boost on theptv1rx. exclusion criteria: * metastasis * previous radiotherapy * any metallic implants or other conditions such to prevent an adequate imaging of target volume * unavailability of previous imrt first phase radiotherapy plans