Kornimate/medical-research-clean huggingface dataset:
prognostication in acute pulmonary embolism

Conditions: Pulmonary Embolism

Summary: to evaluate the effect of a prognosis-guided vs standard medical therapy in the: 1) duration of hospital stay; 2) cost-effectiveness; 3) satisfaction and quality of life; 4) in-hospital and 30-day all-cause mortality; and 5) 30-day readmissions in normotensive patients with acute symptomatic pulmonary embolism (pe). design: prospective, randomized, controlled, single blind trial. normotensive patients with acute symptomatic pe will be randomly assigned to follow a prognosis-guided treatment, or to receive usual care. setting: respiratory, medicine and emergency departments in 15 spanish hospitals. analyses: data for the primary and secondary end points will be analyzed according to the intention-to -treat principle. the intention-to-treat analysis will include all randomly assigned patients. for the efficacy end points, investigators will use the mann-whitney u test. we will also use competing risk regression models according to fine and gray. for the safety end points, comparisons will be made with the use of the chi-square test. separate analyses will be done in key prespecified subgroups of patients, according to age and hospital size.


Eligibility criteria:
inclusion criteria: * confirmed pe by objective testing * signed and dated informed consent of the subject available before the start of any specific trial procedures exclusion criteria: * pregnancy * haemodynamic instability * contraindication to anticoagulant therapy * life expectancy less than 3 months * participation in other clinical trials during the present clinical trial * use of a fibrinolytic agent, surgical thrombectomy, interventional (transcatheter) thrombus aspiration or lysis, or use of a cava filter to treat the index episode of pe * inability to the follow-up visits
the midwest head and neck cancer consortium multi-institutional parathyroid registry

Conditions: Primary Hyperparathyroidism

Summary: the purpose of this registry is to create a database that collects clinical data to improve knowledge about primary hyperparathyroidism.

this will be a multi-institutional prospective study in which patients that have undergone parathyroidectomy with intra-operative pth assessment. the success of minimally invasive parathyroidectomy without and with intra-operative pth will be assessed for each patient. success for exploration without intra-operative pth will be defined as directed exploration with detection of an abnormal parathyroid in the location suggested by imaging. success with intra-operative pth will be defined as per standard protocols (50% or \> decrease in intra-operative pth following excision).

Eligibility criteria:
inclusion criteria: * adult individuals (male and female) who have a personal diagnosis/history of primary hyperparathyroidism. * age 19 or greater. * patients who are seen and treated surgically at unmc's department of otolaryngology- head neck surgery . * able to provide informed consent. exclusion criteria: -no history of primary hyperparathyroidism

Keywords: hyperparathyroidism hypercalcemia
characterizing the genomic landscape of prostate cancer in native american populations (nat-geno)

Conditions: Prostate Cancer

Summary: the purpose of this study is to analyze tumor tissue samples from patients of native american identity with prostate cancer. by examining these samples, researchers hope to understand how different genes in your tumor can influence treatment decisions, how your cancer progresses and the outcome of your cancer.

this study aims to establish a comprehensive database of native american (na) patients diagnosed with prostate cancer (pc), focusing on an in-depth characterization of the genomic landscape. archived tumor tissue collected at screening and peripheral blood samples obtained within the first year of enrollment will serve as the basis for comprehensive molecular analyses. whole exome sequencing (wes) and whole transcriptome sequencing (rna-seq) will be performed to characterize and delineate the genomic and transcriptomic landscape of the study cohort. the study will initially enroll participants at the stephenson cancer center, with planned expansion to additional sites across oklahoma and, subsequently, to other institutions across the united states. oversight will be maintained by the tribal institutional review board and an independent community advisory board to ensure cultural appropriateness, transparency, and sustained community engagement throughout the research process. the overarching objective is to generate insights that will inform the development of personalized treatment strategies in the future.

Eligibility criteria:
inclusion criteria: * written informed consent signed and dated by the patient prior to the performance of any study-specific procedures, sampling, or analyses. * at least 18 years-of-age at the time of signature of the informed consent form (icf). * patients who self-identify as native american. * patients with a pathologically proven diagnosis of pc (any stage). * availability of most recent archived tumor samples. exclusion criteria: * patients not of native american descent or identity. * patient does not have archival tissue available.

Keywords: native american men genomic profile
efficacy of tak-438 compared to ag-1749 (lansoprazole) in the treatment of erosive esophagitis

Conditions: Erosive Esophagitis

Summary: the purpose of this study is to determine the efficacy of tak-438, once daily (qd), compared to lansoprazole in patients with erosive esophagitis of grade a to d as defined by the la classification grading system.


Eligibility criteria:
inclusion criteria: 1. at visit 1 (start of the observation period), the participant must have endoscopically confirmed erosive esophagitis of grade a to d, as defined by the la classification grading system, and the target number of participants who are clearly grade c or d is 30% (120 participants) or more of the total participants. 2. outpatient (including inpatient for examination) exclusion criteria: 1. participants with an esophagus-related complication (eosinophilic esophagitis, esophageal varices, scleroderma, viral or fungal infection, esophageal stenosis, etc.), a history of radiotherapy or cryotherapy of the esophagus, a caustic or physiochemical trauma (esophageal sclerotherapy, etc.). however, participants with schatzki's ring (mucosal tissue ring around inferior esophageal sphincter) or barrett's esophagus are allowed to be included. 2. participants who have received surgery or treatment affecting gastroesophageal reflux (cardioplasty, dilation of esophageal stenosis \[excluding schatzki's ring\], etc.), or who have a history of surgery of stomach or duodenum (excluding removal of benign polyp under endoscopy) 3. participants who have acute upper gastrointestinal bleeding, gastric or duodenal ulcer (mucosal defect with white coating) within 30 days prior to visit 1 (start of the observation period). however, participants with gastric or duodenal erosions are allowed to be included. 4. participants with a previous or current history of zollinger-ellison syndrome, or other gastric acid hypersecretion disorders

Keywords: drug therapy
a randomized controlled trial evaluating the role of negative pressure wound therapy (npwt) for incisional surgical site infections in patients undergoing hepatopancreatobiliary surgery

Conditions: Hepatobiliary Disease; Hepatobiliary Disorders; Surgical Site Infection

Summary: to compare the rates of incisional surgical site infections (issis) within 7 days of hepatopancreatobiliary (hpb) surgery using negative pressure wound therapy (nwpt) versus using standard sterile gauze dressing.


Eligibility criteria:
inclusion criteria: all patients undergoing elective open hpb surgery (benign or malignant disease) of age \> 18 years consenting to the study protocol. exclusion criteria: the patient in which primary wound closure is not achieved. the patient planned for a second look surgery. the patient with the history of long-term antibiotic use (more than a month). past history of open abdominal surgery (less than 1 month).

Keywords: hepatopancreatobiliary surgery surgical site infection negative pressure wound therapy
temozolomide all-case-registered surveillance (designated drug use investigation)(study p05062)

Conditions: Glioma; Astrocytoma

Summary: the purpose of this study is to confirm the safety and efficacy of temozolomide in patients with newly diagnosed malignant glioma (concomitant with radiotherapy and then as monotherapy) and relapsed malignant glioma (as monotherapy) when used in the daily medical practices. post-marketing surveys are not considered applicable clinical trials and thus the results of this survey will not be posted at its conclusion. the results will be submitted to public health officials as required by applicable national and international laws.

patients are invited to participate in the study.

Eligibility criteria:
inclusion criteria: * all patients treated with temozolomide for newly diagnosed malignant glioma (concomitant with radiotherapy and then as monotherapy) and relapsed malignant glioma (as monotherapy). exclusion criteria: * patients with a history of hypersensitivity to temozolomide or dacarbazine. * pregnant women and women who may be pregnant.
fexofenadine as adjuvant therapy in parkinson disease

Conditions: Parkinson Disease

Summary: parkinson's disease (pd) is a chronic, progressive neurological disorder characterized by both motor and non-motor symptoms. pd is the second most common neurodegenerative disorder after alzheimer's disease and the most common movement disorder. pd has age-related pathology; it is present in 1-2% of the population over 60 years of age. the disease is characterized by a triad of disordered voluntary motor activity in the form of bradykinesia (slowness of movement) or even akinesia (absence of movement),rigidity and postural instability, and a resting tremor of the hands and less commonly the feet.


Eligibility criteria:
inclusion criteria:• age ≥ 50 years. both male and female will be included. patients with parkinson's disease on dopamine replacement therapy. modified hoehn and yahr stage, mhy 1-4 exclusion criteria:• atypical parkinsonism or drug-induced parkinsonism breast feeding pregnant women and women with planned pregnancy. patients with significant liver and kidney function abnormalities. history/presence of acute heart disease alcohol and / or drug abusers. patients with known allergy to the study medications other medical conditions that can interfere with results or endanger the participant.

Keywords: fexofenadine
effect of nurse-led intervention programme professional quality of life and psychological distress in nurses

Conditions: Compassion Fatigue

Summary: nurses are at risk in terms of burnout and empathic fatigue. therefore, efforts to protect the mental health of nurses are very important. it is stated that the studies conducted are mostly descriptive and not interventional. in addition, the evidence levels of interventional studies are low.

aim:the aim of this study is to reduce nurses' psychological distress, burnout and secondary trauma stress. design this single-blind randomized controlled trial design was used. measurements were made before, after and 6 months after participants and settings the study was perform at a hospital in turkey. intervention program was applied in 4 week. 84 nurses meeting the criteria were invited to the program.48 nurses agreed to participate. nurses were randomly assigned groups. sample size the sample was calculated with the open epi program. the sample size was calculated as 20 per group. intervention the program was created to reduce nurses' psychological distress, and improve the professional quality of life. the intervention programme were four sessions. the intervention group was divided into two groups. intervention were applied in a comfortable room in the hospital. interventions were based on cognitive behavioral approach. outcome measures the outcomes were compassion fatigue, burnout and compassion satisfaction, psychological distress. these variables were evaluated by the professional quality of life scale (proqol-iv). the ghq-12 is a scale surveying psychological distress observed within the last few weeks. data collection research data were collected before, immediately after, and six months after intervention. validity and reliability measuring tools showing good psychometric properties were used to ensure validity and reliability. volunteer participants were randomly assigned to groups, and the intention-to-treat approach was used for data analysis. the study has been reported in accordance with the consort 2010 statement principles. ethical considerations permission was obtained from the relevant university, and written permission was obtained from the hospital. the participants were informed, all participants gave written consent. data analysis mann whitney u test, and friedman analysis was used. all analyses were made on an intention-to-treat approach. missing data were compensated for using the last observation method carried forward.

Eligibility criteria:
inclusion criteria: * nurses who responded to the questionnaires received a score on compassion fatigue higher than the mean score (20 points) * nurses who worked at clinics and had at least six months of experience exclusion criteria: * nurses who responded to the questionnaires received a score on compassion fatigue lower than the mean score (20 points) * head nurses

Keywords: burnout compassion fatigue nursing psychological distress
nlr and plr levels following ipack block in knee arthroplasty

Conditions: Knee Arthropathy; Knee Osteoarthritis; Knee Pain Chronic

Summary: effect of ipack block on nlr and plr following knee arthroplasty

the nlr is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. nlr is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. dynamic changes in the nlr precede the clinical state for several hours and may alert clinicians early about the ongoing pathological process. nlr is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. it opens a new dimension for clinical medicine to understand better the biology of inflammation, the linkage, and antagonism between innate and adaptive immunity, and its clinical consequences for health and disease. nlr is affected not only by surgical trauma but also by the method of anesthesia. in recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. however, there have been very few studies evaluating the effect of various methods of anesthesia on the nlr. this is the first study to investigate the effect of regional anesthesia on the nlr and plr in patients undergoing knee replacement surgery.

Eligibility criteria:
inclusion criteria: * patients with asa classification i-iii * aged 20-90 years * who will be scheduled for hip arthroplasty under spinal anesthesia exclusion criteria: * patients who have a history of bleeding diathesis * take anticoagulant therapy * history of chronic pain before surgery * multiple trauma * patients unable to assess their pain (dementia) * patients operated under general anesthesia * patients having an infection in region of the procedure * patient who do not accept the procedure
an optimized ultrasound twinkling marker for the imaging of lymph nodes in patients with clinically node-positive breast cancer, the utmost2 trial

Conditions: Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Locally Advanced Breast Carcinoma

Summary: this phase ii trial studies the performance, including ultrasound visibility, of an optimized ultrasound twinkling marker in imaging lymph nodes in patients with clinically node-positive breast cancer. in patients with biopsy-proven breast cancer, biopsy markers are used to identify the sites of cancer involvement in both the breasts and lymph nodes. these biopsy markers are critical for guiding surgical management many months after the marker is placed. for breast radiologists and breast surgeons, there is a need for simple, consistent visibility of biopsy markers by ultrasound, particularly several months after marker placement. ultrasound is the imaging method of choice, particularly for lymph nodes in the armpit (axilla). ultrasound is non-ionizing and is more comfortable for patients compared to mammography. however, ultrasound visibility of these markers is challenging and inconsistent, with ultrasound failing to detect the marker approximately 25% of the time. the mayo-designed investigational biopsy marker takes advantage of an ultrasound phenomenon called twinkling artifact. the mayo-designed optimized ultrasound twinkling marker may work better than standard biopsy clip marker in imaging lymph nodes in patients with clinically node-positive breast cancer.


Eligibility criteria:
inclusion criteria: * patient 18 years or older with breast cancer and biopsy-proven malignant involvement of an axillary lymph node * surgical management will be determined by the surgeon, who will decide if preoperative iodine (i)-125 seed localization of the positive node is necessary or if they will retrieve the positive node with intraoperative ultrasound guidance. during surgery, the targeted node, its associated biopsy markers, i-125 seed if placed, and optimized twinkling marker will be resected. the position of the marker in the lymph node or proximity to the node will be noted from the surgical and pathology documentation * surgery will be performed by one of the surgeons in the division of breast and melanoma surgical oncology (doctor \[dr.\] judy boughey, dr. amy degnim, dr. tina hieken, dr. jeffrey johnson, dr. mary mrdutt, dr. shon black, dr. mara piltin) * patients must be able to understand the study procedures and comply with them for the entire length of the study * no contraception is necessary or required exclusion criteria: * current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements * inability or unwillingness of individual or legal guardian/representative to give written informed consent * current or past participation within a specified timeframe in another clinical trial, as warranted by the administration of this intervention
bowel dysfunction after low rectal resection. an pilot study using psyllium husk in rectal cancer patients.

Conditions: Low Anterior Resection Syndrome; Quality of Life (QOL)

Summary: rectal cancer constitutes 1/3 of more than 4500 annually diagnosed cases of colorectal (crc) in norway. with the advances in radiochemotherapy, and surgical techniques, the long-term survival rate is increasing after surgery regardless of the rising incidences, with a 73% 5-year survival rate in norway (89% for stage i-iii cancer). low anterior resection (lar) is the most commonly performed surgical procedure with curative intent with over 500 procedures per year in norway alone. 80 % of patients subjected to lar suffer from the lar syndrome (lars) which includes grades of bowel incontinence, urgency and tenesmus contributing to reduced quality of life (qol). suggested means of management have been advocated without preceding randomized trials. psyllium husk has been suggested as a nutritional supplement for symptom reduction in patients suffering from lars, but data is limited and no larger, randomized studies regarding its effect on patients with low anterior resection syndrome have been conducted. in this pilot study preceeding a placebo-controlled rct, the investigators aim to improve documentation of a proposed management strategy. the investigators anticipate that a reduction in intestinal symptomburden will increase qol for this large patientgroup.


Eligibility criteria:
inclusion criteria: * operated with low rectal resection for rectal cancer * lars score \>20 at 12 months or more after surgery * written consent exclusion criteria: * various conditions rendering the patient unable to answer questionnaire * lars score 0-20 * contraindications to psyllium husk (hypersensitivity, intestinal obstruction, reduced esophageal function, rare congenital medical conditions such as sucrase-isomaltase deficiency, fructose intolerance and glucose-galactose malabsorbtion)

Keywords: rectal cancer, lars, quality of life, psyllium
effects of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric operations

Conditions: Restrictive Lung Disease

Summary: the study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients

the patients of interest are morbid obese patients scheduled for bariatric surgery. dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung mechanics (dead space and compliance) as well as oxygenation (pf ratio) will be monitored intraoperatively and postoperatively

Eligibility criteria:
inclusion criteria: - morbid obese (body mass index \> 40) with documented restrictive lung disease scheduled to bariatric operation. exclusion criteria: * heart failure * ِِِِarrhythmia * heart block * severe liver or kidney impairment.
short term effect of cervical mobilization vs manipulation on blood pressure in hypertensive subjects

Conditions: Hypertension

Summary: spinal pain or misalignment is a very common disorder affecting a significant number of populations resulting in substantial disability and economic burden. various manual therapeutic techniques such as spinal manipulations and mobilizations can be used to treat and manage pain and movement dysfunctions such as spinal malalignments and associated complications. these manual therapeutic techniques can affect the cardiovascular parameters . -

group a group (n=20). all participants will receive only single session of neck mobilization. grade iv unilateral posteroanterior pressure and sustained extension to be applied restricted joints and muscle energy technique. - group b (n=20) will receive single session of neck manipulation with high-velocity, low-amplitude thrust over restricted joints (one at a time) with the goal of restoring normal range of motion in the joint.

Eligibility criteria:
inclusion criteria: * sbp ranging from 135 to 159 mm hg or dbp ranging from 85 to 99 mm hg over 3 qualifying bp screening visits * the age of participants will range from 27 to 60 years old. * body mass index of participants will range between \< 39 kg/m². exclusion criteria: * cardiovascular diseases or surgery, including second- or third-degree heart block, angina pectoris, defibrillator, valvular disease, recent myocardial infarction, cardiac surgery in the past 12 months. * history of stroke. * body mass index (bmi) greater than 39 kg/m2. * pregnancy.
medical and psychiatric co-morbidity among treatment resistant patients with major depression disorder

Conditions: Major Depressive Disorder

Summary: assessing psychiatric and physiological co-morbidity in trd and non-trd patients


Eligibility criteria:
inclusion criteria: * diagnosis of mdd * received at least one adequate treatment exclusion criteria: -