Kornimate/medical-research-clean huggingface dataset:
taping technique with supervised exercises protocol on pain and functional status in individuals with arthritis

Conditions: Patellofemoral Osteoarthritis

Summary: osteoarthritis (oa) is claimed to be a global burden and a key health issue that affects the large weight-bearing joints of the lower extremity such as the knee and hip joints. the study was aimed to find out the efficacy of the tapping technique in addition to the supervised exercise protocol on pain intensity and functional status of an individual with patella-femoral arthritis.

the study was based on a controlled pretest-posttest experimental group design. after initial screening, forty individuals (mean age 55years, ranged 40-60years) with patello-femoral arthritis randomly (n=20each) assigned into two group a and b. group a received taping technique in addition to the supervised exercises protocol while group b received supervised exercises protocol only. both the groups received their specified treatment 5 consecutive days in a week for 4weeks. data collected for the variables (vas and womac) at day1 pre-intervention (baseline) and at day 28th post-intervention. the t-test used for within and between group analysis with keeping the p\<0.05.

Eligibility criteria:
inclusion criteria: * the individuals with unilateral patella-femoral osteoarthritis * aged between 40-60years; * pain more than 3cm on vas; * crepitus on movement, * showing osteophytes on standing skyline view of radiograph (kallgren/lawrence grade ≥2), * found positive for the special tests (coordination test for the muscle vastus medialis, apprehension test for patellar, clarke's test, and waldron's test with phase i and ii) exclusion criteria: * the individuals with involvement of tibio-femoral joint; * presence of patella alta/baja; * history of rheumatoid arthritis/traumatic knee, knee surgeries within six months * on steroid injection, neurological deficit, fragile skin around the knee, allergic to tape; * poor cooperation

Keywords: patellofemoral osteoarthritis therapeutic exercises vas womac taping
estimate for dietary intakes and hemodialysis patients

Conditions: Nutrition Disorders; Dialysis; Chronic Renal Failure; Dietetician

Summary: the aim of this clinical research is to evaluate the relevance of using the epa slide to estimate dietary intakes in dialysis patients. the obtained results will be compared with the reference technique validated by the has: food intake over 3 days. the aim is also to improve the global management of dialysis patients and improve their quality of life. the aim is to evaluate a quick and easy-to-use tool whose use has been demonstrated in hospitals but for which no study has been carried out in an ambulatory hospitalization context.


Eligibility criteria:
inclusion criteria: * patient must be able to understand and voluntarily sign an informed consent form * patient with chronic end stage renal failure treated with hemodialysis. * patient with age \>= 18 years exclusion criteria: * patient treated by peritoneal dialysis * patient with age \< 18 years * patient with intellectual limitations that may limit the comprehension of questionnaires * patient with communication disorders or verbal comprehension * patient not french speaking * patient with enteral nutrition * patient having been hospitalized for less than 2 months
pre-operative studies for prediction of lymph nodes involvement in endometrial cancer patients

Conditions: Endometrial Cancer

Summary: the study evaluates pre-operative prediction of the risk for lymph nodes involvement in endometrial cancer patients. patients will undergo ultrasound exam (bi and three dimensional) and biomarker test - ca 125, in addition to routine physical and laboratory exams, before surgery. the sonographic evaluation will include endometrial characteristics and myometrial invasion, pelvic findings and enlarged lymph nodes.


Eligibility criteria:
inclusion criteria: * endometrial cancer patients * surgical candidates exclusion criteria: * fertility preservation therapy * contraindication for surgery * stage 2 and higher
personalized and automated digital coaching in people with non-specific chronic low back pain

Conditions: Chronic Low Back Pain

Summary: the investigators hypothesize that a personalized and automated digital coaching could reduce activity limitations in people with chronic low back pain as compared to usual care

non-specific low back pain (lbp) is the leading cause of years of life lived with disability worldwide and its burden is growing alongside the increasing and ageing population. lbp is usually treated according to symptoms duration, presence of concomitant radicular pain and of consistent anatomical abnormalities and is defined according to symptoms duration: acute (\ 12 weeks). the prognosis of acute lbp is excellent, but in 5 to 15% of individuals, lbp becomes chronic. at 6 months, about 10% of individuals with chronic lbp are on sick leave, and at 12 months, 20% report persistent disability. unfavourable evolution of chronic lbp is characterized by onset and persistence of spine-specific disability in all individuals and work absenteeism in working age individuals. the probability of returning to work is only 20% after 1 year of sick leave and 0% after 2 years. multidisciplinary rehabilitation that combines education, physical therapy, cognitive behavioural therapy and rehabilitation is usually offered. however, lack of personalization of these programs could affect their efficacy and systematic evaluation suggests their low cost-effectiveness). current management of non-specific chronic low back pain involves a multidisciplinary approach that typically includes non-opioid analgesics, physical exercise and strength training, education, and cognitive behavioural therapies. therapeutic interventions such as massage, acupuncture, or spinal manipulation may also be beneficial. the investigators hypothesize that a personalized and automated digital coaching could reduce activity limitations in people with chronic lbp, as compared to usual care. participants allocated to the experimental group will be invited to download a smartphone application which will appraise their motivation and automatically propose 1) exercises to be performed at home and adapted to their pain levels; 2) audio recordings for pain management; and 3) educational and coaching content adapted to their motivation. in addition, the smartphone application enables users to plan their home exercises.

Eligibility criteria:
inclusion criteria: * adults aged 18 or over * having non-specific chronic lbp * participating in the "compare" e-cohort * having provided consent for their data to be used to assess trial eligibility * and to be randomized if eligible * and to, allow their data to be used to evaluate intervention effectiveness without being notified that they are in the control group, if randomized to usual the control group * having a valid email address * able to read and write french having a smartphone functioning with android acquired after 2020 exclusion criteria: * no exclusion criteria

Keywords: chronic low back pain digital coaching
tetanus immunization in subjects with no immunization history or with tetanus antibody levels below protective levels

Conditions: Tetanus

Summary: the goal of this study is to re-evaluate the tetanus antibody pharmacokinetic profile when tetanus immune globulin (human)(tig) and tetanus vaccine (tetanus toxoid; tt) are given concurrently with strict control on the anatomical location and timing of administration of tig and tt. pharmacokinetic profile of antibody titer including the duration of adequate titer protection provided by tig and tt given in combination will be assessed using a standardized administration regimen and standardized antibody assay procedure. this study may provide evidence for the recommendations of the world health organisation (who) whereby dual coverage with both a vaccine and tetanus hyperimmune would ideally provide the best coverage for anyone with the potential of developing tetanus.

this is a prospective, open-label, single-center trial including a single group of subjects with no known primary immunization history with tt or \>10 years have passed since the last dose of tetanus containing vaccine was received. the study will enroll six subjects who would receive both dt and tig concurrently on day 1. all dosed subjects will be followed for 40 days during which day 1, 2, 3, 4, 5, 7, 14, 21, 30 and 40 time levels of tetanus antibodies will be measured in order to determine the serum level vs. time curve, cmax, tmax, and duration of protective antibody levels.

Eligibility criteria:
inclusion criteria: * age between 18 and 90 years. * signed a written informed consent prior to initiation of any study-related procedures. * no known primary immunization history with tt/dt or \>10 years have passed since the last dose of tetanus containing vaccine was received. subjects with unknown or uncertain previous vaccination histories are considered to have no previous tetanus and toxoid doses. subjects who have had military service since 1941 will be considered to have had 1 dose of tetanus vaccine. * subjects must have documented tetanus antibody levels that are non-protective levels (\< 0.15 iu/ml). * subjects must be free of any presenting wound or wound infection exclusion criteria: * history or suspicion of significant allergic reaction to intravenous immune globulin, and or blood products * a history of selective iga deficiency (serum level \<5.0 mg/dl) and known antibodies to iga * congestive heart failure (new york association stage greater than class ii) * conditions whose symptoms and effects could alter protein catabolism and/or igg utilization (e.g. protein-losing enteropathies, nephrotic syndrome) * women of child bearing potential who do not practice adequate contraception (i.e. chemical or mechanical methods) and pregnant or lactating females * subjects who have severe thrombocytopenia or any coagulation disorder that would contraindicate intramuscular injections * tig therapy within the previous six months * investigational drug therapy within the previous three months * history of thromboembolism

Keywords: trismus lockjaw
amyloid proteins from medullary thyroid cancer and laryngeal amyloidosis

Conditions: Amyloid; Medullary Thyroid Cancer; Alzheimer Disease; Dementia

Summary: using excess tumour samples that contain amyoid, from patients with medullary thyroid cancer, we aim to determine the structures of ex vivo amyloid fibrils from human tumour tissue samples and compare them with that of existing stock of in vitro formed amyloid fibrils. this will permit the analysis of the effects of gene mutation and post-translational modification on the development of amyloid from a disease state. amyloid is known to accumulate in the brain tissue of patients with neuro-degenerative conditions such as alzheimer's disease and dementia. therefore solving the structure of amyloid fibrils may aid the development of future treatments for these conditions.

this is an anonymous, voluntary inclusion, laboratory based, basic science research study. appropriate patients who meet the inclusion criteria and complete the consent process will be asked to donate a small sample of excess tumour tissue after the completion of their surgical procedure. this tissue will be transferred to the research laboratory in leeds university for analysis and subject to a variety of investigations and scientific procedures to achieve the study objectives. these include: 1. - amyloid extraction by tissue homogenization and centrifugation as already documented in the literature. 2. - mass spectrometry analysis to identify and characterize the most prominent proteins present in the amyloid deposits and their possible post-translational modifications. 3. - transmission electron microscopy to characterize at the gross features of the extracted amyloid fibrils at low resolution (\>20å). this relatively simple procedure allows for quick characterization of the samples in order to optimize them for atomic force microscopy (afm) and cryo-electron microscopy (cryo-em). 4. - atomic force microscopy to characterize helical parameters of the amyloid fibrils needed to calculate the structure from cryo-em data. 5. - cryo-electron microscopy to elucidate the structure of the amyloids extracted from tissue affected in each disease

Eligibility criteria:
inclusion criteria: * diagnosed with known or suspected mtc or la * age \>= 18 years, no upper age limit * able to provide informed consent for both surgical treatment and inclusion into this study * for mtc patients, treatment recommendation from the thyroid mdt is for either hemithyroidectomy or total thyroidectomy * for la patients, agreement with their attending clinician to undergo surgical debulking of disease under general anaesthetic. the procedure is called 'microlaryngoscopy and biopsy/debulking' exclusion criteria: * no known or suspected diagnosis of mtc or la * age \<18 years * unable to provide informed consent * treatment recommendation from thyroid mdt is for any treatment excluding primary surgery (ie palliation, best supportive care, chemotherapy, radiotherapy etc) * for la patients, no agreement between patient and attending clinician to proceed with surgery as primary treatment.
to evaluate the efficacy and safety of ak111 injection in the treatment of moderate to severe plaque psoriasis

Conditions: Psoriasis; Skin Diseases

Summary: this is a randomized, double-blind phase ii clinical study to evaluate the efficacy and safety of ak111 in the treatment of subjects with moderate to severe plaque psoriasis.

this is a randomized, double-blind phase ii clinical study to evaluate the efficacy and safety of ak111 in the treatment of subjects with moderate to severe plaque psoriasis. the study has 2 parts: first part (randomized double-blind) and second part (open).

Eligibility criteria:
inclusion criteria: 1. male or female subjects aged ≥18 years old. 2. subjects with moderate to severe plaque psoriasis with or without psoriatic arthritis. 3. at screening and baseline, pasi score ≥ 12, bsa ≥ 10%, spga ≥ 3. 4. suitable for systematic therapy assessed by investigators. 5. subjects who are women of childbearing potential must be practicing an adequate, medically acceptable method of birth control during the study and for at least 6 months after the last investigational drug administration. exclusion criteria: 1. types of psoriasis other than chronic plaque-type psoriasis. 2. drug-induced psoriasis. 3. evidence of active tb. patients with evidence of latent tuberculosis may enter the trial after sufficient treatment had initiated and maintained according to protocol. 4. positive results of confirmatory test for hepatitis b, hepatitis c, human immunodeficiency virus (hiv) or syphilis. 5. history of repeated chronic infection, had any serious infection or systemic infection within 2 months before screening. 6. progressive or uncontrolled symptoms or signs of circulatory, respiratory, digestive, neuropsychiatric or psychological,hematological, endocrine and other systems before randomization. 7. history of malignant tumour within 5 years before screening. 8. previous or current autoimmune diseases. 9. allergic to any component of the investigational drug, or have had severe allergic reactions to monoclonal antibodies.
dynamic epidermal cooling during pulsed dye laser treatment of port wine stain birthmark at high fluences

Conditions: Port Wine Stain

Summary: the purpose of the study is to improve the efficacy of pulsed dye laser treatment of port wine stain birthmarks. involvement in the protocol will involve formal documentation of the level of treatment pain, duration of post-treatment purpura and incidence of side effects. in addition, measurements will be taken of blood substances that promote blood vessel formation/regrowth and non-invasive reflectance measurements and photographs will be taken before and after treatment. the objective of this study is to document the degree of port wine stain lightening, the incidence of side effects and the presence of angiogenic factors induced during treatment with the pulsed dye laser in association with cooling agent. this information ultimately lead to improved treatment.

the flashlamp-pumped pulsed dye laser has offered the best results with the lowest incidence of side effects. the yellow light is preferentially absorbed by hemoglobin allowing more selective destruction of the ectatic capillaries in the dermis. the flashlamp-pumped pulsed dye laser has become the treatment of choice for port wine stain birthmarks; however, therapeutic challenges remain. the epidermis is not totally spared due to partial absorption of energy therein by melanin which presents an optical barrier through which the light must pass to reach the underlying blood vessels. absorption of laser energy by melanin causes localized heating in the epidermis, which may, if not controlled, produce permanent complications such as hypertrophic scarring or dyspigmentation. clinical studies have demonstrated the efficacy and safety of cryogen spray cooling during pulsed laser treatment of port wine stain birthmarks. this technology allows the use of higher incident laser light dosages and has been demonstrated to improve treatment results. cryogen spray cooling also decreases treatment pain and the duration of post-laser treatment purpura.

Eligibility criteria:
inclusion criteria: * diagnosis of pws birthmark or age and sex matched control of a subject with a pws birthmark * apparent good health as documented by medical history and physical examination * ability to understand and carry out subject instructions exclusion criteria: * pregnancy * history of cutaneous photosensitivity * history of photodermatoses, skin cancer or other cancer * any therapy to the proposed treatment sites within the previous two months * current participation in any other investigational drug evaluation * concurrent use of known photosensitizing drugs * inability to understand and carry out subject instructions

Keywords: port wine stain
balance training after stroke - a randomized, controled pilot study

Conditions: Stroke

Summary: this pilot study is part of a master's thesis. in the rehabilitation of stroke patients should be compared whether individual balance training has a greater effect than group balance training. the result is determined based on the walking speed.

the rehaclinic kilchberg is a neurological rehabilitation facility with the phases b-d. between february and the end of march, out of 78 patients, 71% of the patients had a stroke. therefore, my choice of topic for the master's thesis fell on balance training of patients after a stroke. the duration of the study is based on the timetable for the master's thesis. initially, 20 stroke patients will be recruited. when the number is reached, the study is completed to begin descriptive statistics and analyze potential bias. deficits in the vestibular, visual, motor, and / or somatosensory systems lead to falls in the first 6 months after the stroke. this affects approximately 46% of patients. but also cognitive processes, such as attention and concentration. therefore, the treatment must be adapted to the respective strategy of the patient. if the patient increasingly uses the visual system, the therapy has to work a lot with the eyes closed. in turn, if he uses more of the sensorimotor system is increasingly trained with unstable documents. after this system, the balance program was set up. it is the same for the intervention and control group to make a difference between individual and group training.

Eligibility criteria:
inclusion criteria: * stroke starting from rehabilitation phase b * ability to understand therapy instructions * walkable with aids exclusion criteria: * neurodegenerative disease * non-stroke dizziness * cardiopulmonary insufficiency * polyneuropathy * peripheral vascular disease

Keywords: balance training gait speed
the observational study of cardiac and pulmonary ultrasound and evaluation of treatment of severe patients with novel coronavirus pneumonia

Conditions: Novel Coronavirus Pneumonia

Summary: complete the examination of cardio-pulmonary ultrasound in accordance with the a-ccue process of patients with novel coronavirus bedside. to summarize and analyze the characteristics of cardiopulmonary ultrasound in patients with novel coronavirus pneumonia, and assess the relationship between pulmonary ultrasound imaging score and national early warning score(news) and prognosis. auto line b is a method which is based on artificial intelligence is used to calculate the lungs ultrasonic b line numbers reviewing the status of patients with lung, and also evaluate patients' lungs using the traditional artificial semi-quantitative method, to evaluate those two kinds of evaluation methods for the evaluation of patients with lung condition effects are consistent or not, and verify consistency of ultrasonic evaluation method and the way of ct evaluation.


Eligibility criteria:
inclusion criteria: 1. age \>18 years old 2. identify the patients infected with novel coronavirus pneumonia; 3. the patient completed ct examination; 4. sign the informed consent. exclusion criteria: 1. age \< 18; 2. those who cannot complete cardiopulmonary ultrasound according to the a-ccue process; 3. the patient or his guardian requests to withdraw from the researcher;
steroid injection treatment of carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: the aim of this study is to assess the efficacy of injecting steroid into the carpal tunnel in relieving symptoms of carpal tunnel syndrome for at least 1 year with outcomes measured with patient evaluated symptoms score.out of the patients referred by primary care, those with a clinical diagnosis of cts who have tried wrist splint and whose symptom severity is judged by the examining surgeon to warrant surgery are offered to be put on the waiting list for carpal tunnel release. this means a waiting time of approximately 3 months. patients who give informed consent will be asked to attend the outpatient clinic for a physical examination followed by allocation to one of the three trial groups. immediately following the allocation the patients will receive the assigned treatment.

www.biomedcentral.com/1471-2474/11/76

Eligibility criteria:
inclusion criteria: * primary, idiopathic cts * age 18-70 years, either gender * symptom duration of at least 3 months and inadequate response to wrist splint * symptoms of classic or probable cts according to the diagnostic criteria in katz hand diagram * nerve conduction studies showing median neuropathy at the wrist and no other abnormalities or, in the absence of abnormal nerve conduction study results, 2 surgeons should independently diagnose the patient with cts. * scheduled for carpal tunnel release (ie, symptom severity indicating need for surgery)exclusion criteria exclusion criteria: * previous steroid injection for cts in the same wrist * inflammatory joint disease, diabetes mellitus· vibration-induced neuropathy, polyneuropathy * pregnancy * trauma to the affected hand in the previous year * previous cts surgery in the affected hand * inability to complete questionnaires due to language problem or cognitive disorder * severe medical illness * known abuse of drugs and/or alcohol