Kornimate/medical-research-clean huggingface dataset:
long-term adverse effects after bariatric surgery on oesophagus epithelium

Conditions: Morbid Obesity

Summary: the goal of this trial is to examine long-term effects of laparoscopic gastric bypass (lrygb) and sleeve gastrectomy (lsg) on oesophageal symptoms and disease, including the presence of barrett oesophagus ≥ 5 years post-surgery.

bariatric surgery shows impressive results in terms of weight loss and resolution of comorbidities. still, there are questions as to the frequency of long-term adverse effects: the prevalence and causes of post-operative swallowing disorders and reflux disease are uncertain. recently, independent study groups described a high incidence of barrett oesophagus post lsg. additional research is urgently needed. the goal of this trial is to examine long-term effects of laparoscopic gastric bypass (lrygb) and sleeve gastrectomy (lsg) on oesophageal symptoms and disease, including the presence of barrett oesophagus ≥ 5 years post-surgery.

Eligibility criteria:
inclusion criteria: * patients who received laparoscopic gastric bypass or laparoscopic sleeve gastrectomy ≥ 5 years ago as a primary bariatric procedure will be eligible for this study. exclusion criteria: * patients who received laparoscopic gastric bypass or laparoscopic sleeve gastrectomy as a secondary bariatric procedure (e.g. after gastric banding), * patients who received a secondary bariatric operation after laparoscopic gastric bypass or laparoscopic sleeve gastrectomy( e.g. biliopancreatic diversion)
atomoxetine and huntington's disease

Conditions: Huntington Disease; Chorea

Summary: the purpose of this research study is to evaluate the effect of atomoxetine (also known as strattera) compared to placebo (inactive substance) on daily activities such as attention and focus, thinking ability and muscle movements in subjects with early huntington disease (hd) and attention deficit disorder (add).

no medications have been investigated to improve attention and executive functions in patients with huntington's disease, despite the evidence that these cognitive domains can be abnormal even before motor symptom onset. because cognitive symptoms are highly associated with functional disability, treatments aimed at improving cognitive functions would be of significant benefit to patients in the early stages of the disease. atomoxetine is the ideal choice for such a trial. it has proven efficacy in adults with attention deficit hyperactivity disorder (adhd) and it selectively targets norepinephrine and dopamine in the prefrontal cortex rather than in subcortical areas. this selectivity is an advantage for patients with hd, because motor side effects are less likely to be facilitated than with a psychostimulant. the present study is a feasibility study in which we propose to administer either 80 milligram (mg) atomoxetine for 4 weeks or placebo to 20 patients with early hd who also complain of mild cognitive symptoms. the groups will then crossover to the other condition (atomoxetine or placebo). participants will be assessed on measures of adhd symptoms and a sensitive battery of neuropsychological tests. based on the shared neural circuitry in adhd and hd, and the demonstrated effectiveness of atomoxetine on attention in adults with adhd, improved performance on cognitive tests of attention and executive functions and on subjects' report of adhd symptoms are expected in the atomoxetine treatment phase. no changes in motor status are predicted during the study.

Eligibility criteria:
inclusion criteria: * confirmed huntington's disease (hd) diagnosis * age 18 to 65 * must have mild hd * must have complaints of poor attention exclusion criteria: * childhood history of attention deficit hyperactivity disorder (adhd) symptoms * diagnosis of schizophrenia, bipolar affective disorder, dementia, delirium or severe anxiety * current use of a monoamine oxidase inhibitor (maoi) medication * pregnancy * uncontrolled hypertension * tachycardia * cardiovascular or cerebrovascular disease * history of a loss of consciousness for greater than (or equal to) 5 minutes * having any neurological disorder or insult other than huntington disease

Keywords: huntington disease chorea attention adhd add strattera atomoxetine
pain severity in flapless dental implant placement using laser

Conditions: Jaw, Edentulous, Partially

Summary: the goal of this split-mouth randomized clinical trial study was to investigate the effect of using a laser on pain and discomfort following flapless dental implant surgery. it was hypothesized that laser did not have any impact on post-op pain. therefore, the study aimed to compare pain and discomfort following flapless dental implant surgeries with or without a laser.


Eligibility criteria:
inclusion criteria: 1. adult human subjects agreed to participate in the study and return on follow-up times 2. subjects eligible for receiving dental implants 3. subjects with an edentulous area in the posterior of the mandible bilaterally 3- subjects with sufficient bone width and height (\>5 mm width, and \>10 mm height) at the implant sites 4. subjects with sufficient keratinization tissue at the implant sites exclusion criteria: 1. subjects refused to return for follow-up or refused study enrollment. 2. subjects with uncontrolled systemic diseases 3. subjects younger than 18 years 4. subjects receiving psychotropic drugs

Keywords: jaw, edentulous, partially pain measurement laser therapy dental implants randomized controlled trial
an open label study to describe the pharmacokinetics of daptomycin in infants

Conditions: Sepsis

Summary: this is a safety and pharmacokinetic study of single-dose daptomycin in infants \> 48 hours and \< 120 days of age with suspected systemic infections. the investigators will enroll a total of 24 infants in 4 gestational age/postnatal age cohorts. interim analyses will be performed after 3 infants are enrolled in each cohort. the investigators anticipate that 6 mg/kg of daptomycin will yield an auc \<740 mch\*hr/ml.


Eligibility criteria:
inclusion criteria: 1. \> 48 hours and \<120 days of age at the time of daptomycin administration 2. sufficient venous access to permit administration of study medication 3. suspected to have systemic infection and appropriate cultures (blood +/- urine/csf) are obtained within 72 hours of study entry 4. availability and willingness of the parent/legally authorized representative to provide written informed consent exclusion criteria: 1. history of anaphylaxis attributed to daptomycin 2. previous participation in the study 3. exposure to daptomycin in the month prior to the study 4. serum creatinine \>1.0 mg/dl 5. concomitant administration of tobramycin

Keywords: infants daptomycin
post-treatment effects of naltrexone

Conditions: Alcoholism

Summary: the aims of this protocol are to compare 3 and 6 months of naltrexone treatment coupled with two psychotherapies that differ in scope and intensity. the effect of these treatments will be assessed with patients who differ in their psychosocial need and resources at their disposal, and in their level of cravings for alcohol.


Eligibility criteria:
inclusion criteria: * meets current diagnosis of alcohol dependence and have been abstinent for a minimum of 3 and maximum of 21 days prior to treatment * must be able to participate in an 18-month outpatient study, and live within a one hour or less commute to treatment facility. * must be fluent in english. * women of childbearing potential must have a negative pregnancy test. exclusion criteria: * severe hepatic disease or a liver function test greater than 4 times normal. * opiate use in the last 14 days or a history of opioid dependence in the past year. * pregnant or lactating females who are not using a reliable method of birth control. * inability to follow medication instructions and safety precautions. * comorbid substance dependence diagnosis in the past 6-months, excluding nicotine or marijuana dependence. * use of medications intended to decrease drinking. * meets criteria for bipolar disorder, schizophrenia, bulimia/anorexia, dementia, major depression.
propranolol in severely burned children

Conditions: Burn

Summary: to determine the safety and efficacy of administration of propranolol for reducing heart rate and blood pressure in burn injury.

other purposes of this study are to study the effect on muscle function, the infectious process, sepsis, systemic inflammation and long-term scarring. quality of life will also be looked at over time.

Eligibility criteria:
inclusion criteria: * burns covering \>20% of the total body surface are * age of 0 to 18 years * patient arrival to the burn center within 96 hours (4 days) of burn injury * require \> 1 surgical procedure exclusion criteria: * pregnancy * known history of aids, aids related complex, or hiv * history of cancer within 5 years * existence of pre-morbid conditions * asthma * congestive heart failure (measured ejection fraction \< 20%) * medical condition requiring glucocorticoid treatment * burn injury due to chemical burns * burn injury due to deep electrical injury (decision of hospital pi) * presence of anoxic brain injury that is not expected to result in complete recovery * decision not to treat due to burn injury severity
effectiveness of a buteyko-based breathing technique for asthma patients

Conditions: Asthma

Summary: the purpose of this study is to investigate the effects of a buteyko-based breathing technique on physiological and psychological parameters in adults with asthma

the investigators explore the effects of a buteyko-based breathing technique training using a treatment group vs. control group design and a repeated measures design with follow-up measurements 3 and 6 months after the intervention. the sample size calculation was made for an effect of d = .20 with repeated measures, a power of 1- β = .80 and α = .05. additionally the investigators plan to take measurements (only once) from healthy volunteers matching them (age and gender) with the asthma patients.

Eligibility criteria:
inclusion criteria: * written informed consent, regular intake of prescribed asthma medication according to the awmf scheme level 1, native speaker of german exclusion criteria: * participation in another study, comorbidities (heart diseases, cancer still under treatment, psychiatric diseases)

Keywords: buteyko-based breathing technique training
d-chiroinositol administration in hypogonadal males

Conditions: Male Hypogonadism; Sexual Dysfunction

Summary: d-chiroinositol (dci), is known as second messenger of insulin pathway, but recently several works have reported the influence of dci on steroidogenesis. in particular, the dci capabilities to regulate aromatase expression and testosterone biosynthesis are arising. in this regard, dci administration in case of reduced levels of testosterone, could be a good therapeutic opportunity. for this reason, the treatment of late-onset male hypogonadism (loh) in undoubtedly an interesting target. loh is a reduction of testosterone level due to advancing age, currently treated with testosterone replacement therapy (trt). unfortunately, there is a lack of information about trt safety, especially in older men. for these reasons, the aim of this study is to evaluate the effect of dci treatment on testosterone accumulation in loh patient.


Eligibility criteria:
inclusion criteria: * men, with a diagnosis of late-onset male hypogonadism * insulin resistance (homa index \> 2,5) * bmi between 25 and 30 exclusion criteria: * alcohol intake and/or drug abuse * recent hormonal treatment * smoking * obesity * systemic or endocrine diseases * male accessory gland infection * clinical history of cryptorchidism or varicocele and micro-orchidism

Keywords: male hypogonadism testosterone aromatase d-chiroinositol sexual dysfunction
the effect-site concentration of remifentanil for preventing cough during emergence from balanced anesthesia for nasal surgery

Conditions: Cough

Summary: after nasal surgery, emergence cough or straining will produce venous engorgement and increase bleeding from the surgical site, so the necessity for smooth extubation without severe cough during emergence provides a challenge for the anesthetists. recently, remifentanil is commonly used short-acting opioid, and several studies have demonstrated the antitussive effect of remifentanil via effect-site target-controlled infusion during emergence. however, there may be gender difference in response to opioid, and the previous studies about antitussive effect of remifentanil are targeted at female patients and there is no investigation of effect site concentration of remifentanil for male patients undergoing nasal surgery. the purpose of this study is to evaluate the effect-site concentration of remifentanil via target-controlled infusion for preventing cough in man after sevofluorane balanced anesthesia.


Eligibility criteria:
inclusion criteria: * all male aged 18-60 years * asa(american society of anesthesiologists)physical status i or ii * who underwent ess(endoscopic sinus surgery)or septoplasty under sevoflurane-remifentanil balanced anesthesia exclusion criteria: * predicted difficult airway, * bmi(body mass index) of more than 30 kg/m2, * chronic respiratory disease, * recent respiratory track infection, * chronic coughing, * significant cardiovascular, * hepatic or renal disease, * current smokers * medical history of medication of opioid or acei(angiotensin covering enzyme inhibitor)

Keywords: nasal surgery endoscopic sinus surgery septoplasty cough
the mechanism of ctbs targeting dentate nucleus for dre

Conditions: Transcranial Magnetic Stimulation; Drug Resistant Epilepsy; Cerebellum

Summary: in our previous cross-over study--the continuous θ burst stimulation (ctbs) targeting cerebellum dentate nucleus of 44 drug-refractory epilepsy (dre) patients, a significant reduction in seizure frequency was observed. however, the mechanism of this target to reduce seizures is still unknown. this study aims to explore the mechanism of ctbs targeting cerebellum dentate nucleus for dre, in order to provide theoretical support for this treatment method. a total of 50 patients with dre will have 2-week ctbs treatment via accurate navigation to bilateral cerebellar dentate nucleus. participants will be took tms-eeg, functional magnetic resonance imaging, and diffusion tensor imaging (dti) pre- and post- treatment. these three examinations will help to analyze the brain functional connectivity and suggest the mechanism of action of this treatment.


Eligibility criteria:
inclusion criteria: 1. participants aged between 18 and 60, 2. participants who are in line with the diagnostic criteria for epilepsy and drug-refractory epilepsy (dre), 3. participants who have duration of epilepsy ≥ 2 years and seizure frequency ≥ 2 seizures per month, 4. the type and dosage of anti-seizure medications (asms) keep unchanged during the experiment, 5. participants and their families are aware of this study and sign informed consent. exclusion criteria: 1. participants who are unable to cooperate with treatment and examinations, 2. participants who are in status epilepticus (se), 3. participants who are complicated with a serious infection, cerebrovascular disease, malignant tumour, and other nervous system diseases, with serious dysfunction of heart, liver, kidney, and other organs, and with psychiatric disorders, 4. participants who are pregnant or breastfeeding, 5. participants have contraindications of tms and mri, that is, the presence of metal or implanted devices in the body, such as cardiac pacemaker, deep brain stimulator, etc, 6. participants who are in other clinical trials, 7. participants who withdraw informed consent.
a study of attitudes about the risk of developing type 2 diabetes

Conditions: Prediabetic State

Summary: diabetes mellitus (dm) type 2 is well recognized as a major cause of morbidity and mortality in the united states, as well as a significant contributor to health disparities within the population. changes in demographic and lifestyle characteristics in the population have led to a progressive increase in the prevalence of both diabetes and impaired glucose tolerance (igt), a precursor to dm type 2. although pharmacologic interventions have proven to be successful in blocking the progression from igt to dm, they have not been as effective as diet and exercise modification. studies of behavioral interventions in igt have focused on the outcomes of improved dm risk factors and decreased progression to dm, but have either required extensive interventions that lack applicability to the general population or have utilized more modest interventions with no effect on risk factors. these studies have not included impact evaluations to assess the effect of knowledge of igt status on motivation to change and perceived risk. this study will assess the impact of knowledge of igt on the likelihood of altering health-related behaviors, utilizing the health belief model as a conceptual framework. subjects will be randomized to one of four treatment arms, organized in a factorial design to (1) assess the impact of ogtt testing on motivation to change behaviors and (2) evaluate the efficacy of a novel educational intervention linked to patients' learning styles. this evaluation will determine whether ogtt testing is more beneficial as a cue to action to motivate behavior change than a multifactorial assessment of diabetes risk. additionally, the improvement in health motivation after an educational intervention is expected to be enhanced when the educational method is tailored to the individual's preferred learning style. this information will provide the foundation for more efficient behavioral interventions for patients at high risk for dm type 2.


Eligibility criteria:
inclusion criteria: * increased risk for diabetes type 2 by one of the following characteristics: (1) bmi\>30, (2) age\>45, (3) first-degree relative with type 2 diabetes, (4) history of gestational diabetes, (5) prior elevated fasting glucose in the previous year. exclusion criteria: * history of diabetes (not gestational diabetes) * current laboratory results consistent with diabetes * current pregnancy

Keywords: glucose tolerance test health knowledge, attitudes, practice motivation communication health behavior
effect of using pictograms on improving depression and anxiety among type 2 diabetic patients.

Conditions: Type 2 Diabetes

Summary: we will study the impact of using pictograms on improving depression and anxiety among type 2 diabetic patients, we suppose that patients who received pictograms-enriched labels will have lower levels of depression and anxiety in comparison with those who will not receive after three month follow-up evaluation.


Eligibility criteria:
inclusion criteria: * participants are eligible if they are jordanian adults, aged 18 or older, who have been clinically diagnosed with t2dm for at least 6 months, having low health literacy (individuals who obtained 66 or lower scores in the full tofhla instrument are considered as individuals with "low literacy" in the study) \[24\], come personally for the refill. exclusion criteria: * patients who are unable to communicate verbally (aphasic or with hearing impairment), those with any visual, learning disabilities, and psychological or hepatorenal disease (according to the clinical diagnosis by a physician), and those deemed too ill or frail to attend the clinic, and who have participated in other diabetes education research projects will be excluded.
a prospective study of vasopressor on cerebral oxygenation during general anesthesia

Conditions: Hypotension Drug-Induced

Summary: the purpose of this study is to investigate whether norepinephrine(n), phenylephrine(p) or ephedrine(e) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.

this study was a single-center, randomized, double-blinded, controlled trial. first, the effects of e, p, or n on cerebral oxygen saturation(rsco2) under general anesthesia in abdominal surgery were studied. patients with abdominal surgery were evaluated using near-infrared spectroscopy. continual changes in systolic blood pressure (sbp), diastolic blood pressure (dbp), mean arterial blood pressure (map), heart rate (hr), stroke volume (sv), cardiac output (co) and systemic vascular resistance (svr) will be measured with lidco rapidv3 monitoring system. to investigate the individualized therapeutic options \& specific mechanisms of the three vasopressors on rsco2 and co.

Eligibility criteria:
inclusion criteria: * asa i-iii, age 18-80 years * elective abdominal surgery * signed informed consent exclusion criteria: * asa≥iv * preoperative unstable blood hemodynamics * allergy to ephedrine, phenylephrine or norepinephrine * decrease in map \<20% * severe cardiovascular disorder

Keywords: abdominal surgery ephedrine phenylephrine norepinephrine cerebral oxygen saturation map co general anesthesia propofol sevoflurane hypotension drug-induced
an observational study of risk factors and long-term prognosis of patients with liver abscess in the "real-world"

Conditions: Liver Abscess, Pyogenic; Liver Abscess; Abscess; Infections

Summary: pyogenic liver abscess is one of the most common visceral abscesses, its incidence is increasing worldwide. according to the previous literature, the mortality rate of pyogenic liver abscess is as high as 31% and become a serious social health problem. however, the data of prospective observational real-world studies are scarce and no relevant research of the liver histological change has been reported, so the long-term prognosis and the risk factors for pyogenic liver abscess are still unknown. patients will be followed up prospectively for a period of 2 years and observed clinical prognosis (all-cause mortality, the recurrence rate, and the rehospitalization rate). the investigators will investigate the predictive value of clinical risk factors for clinical prognosis and establish clinical prediction models to predict the long-term prognosis of pyogenic liver abscesses.


Eligibility criteria:
inclusion criteria: * patients older than 18 years of age; * irrespective of gender; * symptomatic patients of liver abscess confirmed with radiology imaging, either by ultrasonography or computed tomography scan. exclusion criteria: * patients \<18 years old; * pregnancy at presentation.

Keywords: pyogenic liver abscess liver histological change