Kornimate/medical-research-clean huggingface dataset:
exosomes detection for the prediction of the efficacy and adverse reactions of anlotinib in patients with advanced nsclc

Conditions: Non-Small Cell Lung Cancer

Summary: exosomes detection for the prediction of the efficacy and adverse reactions of anlotinib in patients with advanced nsclc

explore blood exosomal mirna as a biomarker for predicting the efficacy or risk of serious adverse reactions in patients with advanced lung adenocarcinoma (or lung squamous cell carcinoma) after anlotinib treatment.

Eligibility criteria:
inclusion criteria: 1. patients who have signed informed consent. 2. male or female, age between 18-75 years old. 3. patients with advanced lung adenocarcinoma who failed standard treatment. 4. complete prognostic assessment information. 5. efficacy evaluation: pr/sd/pd. 6. anlotinib single drug administration. 7. ecog ps score: 0-1. 8. patient's expected survival time is greater than 12 weeks. 9. the functions of main organs meets the following criteria: 1) absolute neutrophil count (anc) ≥1.5×10\^9/l; 2) white blood cell count (wbc) ≥3.0×10\^9/l; 3) platelet (plt) ≥100×10\^9/l; 4) hemoglobin (hb) ≥90g/l; 5); creatinine clearance ≥50ml/min or serum creatinine (cr) ≤1.5×upper limit of normal (uln); 6)serum total bilirubin (tbil) ≤1.5×uln; 7) alanine aminotransferase (alt) and aspartate aminotransferase (ast) ≤2.5×uln; 8) left ventricular ejection fraction (lvef) ≥ the lower limit of the normal (50%); 9) serum cr ≤ 1.5uln or creatinine clearance (ccr) ≥ 60ml / min; 10) alt and ast ≤ 5uln; 11) activated partial coagulation activity enzyme time (aptt), international normalized ratio (inr), prothrombin time (pt)≤1.5×uln. 10. women of childbearing age should make sure their pregnancy test is negative within 2 weeks before the study, and keep using contraceptive methods during the study and within 24 weeks after the last administration of anlotinib. for men, they must agree to use contraceptive methods during the study period and also 24 weeks after the last administration of anlotinib. exclusion criteria: 1. patients whose plasma is not qualified for the test (hemolysis, precipitation, etc.) 2. patients who have used anlotinib before. 3. pathological diagnosis results do not meet the requirements for entry. 4. patients never used tkis. 5. patients with hemoptysis, more than 50ml per day. 6. patients with other kinds of malignancies within 5 years. 7. patients who have taken systemic therapy (immunotherapy, cytotoxic therapy, or other targeted therapies) within 6 weeks before grouping. 8. patients who have symptoms of diseases that affect the patient's medication. 9. patients who have suffered non-relieving toxicity from previous treatment. 10. patients who have habitus of hemorrhage; the history of ulcer or fracture and non healing wounds. 11. patients who have suffered arterial/venous thrombosis within 24 weeks. 12. patients who have been diagnosed with mental disorder. 13. patients who have suffered other diseases that may affect the patient's life safety and the results of this experiment.

Keywords: anlotinib non-small cell lung cancer exosome detection biomarker
longitudinal at home smell testing to detect infection by sars-cov-2

Conditions: Anosmia; Asymptomatic COVID-19; COVID-19 Respiratory Infection; Influenza; Healthy; PASC Post Acute Sequelae of COVID 19

Summary: the purpose of this study is to learn more about how to better track smell recovery in people who have been infected with the sars-cov-2 virus (which causes covid-19). many people who have been infected by this virus develop changes in their sense of smell (olfaction). we are interested in measuring smell function objectively via smell cards that test odor intensity, identification, and discrimination. objective and precise olfactory testing that can be performed in the convenience of one's home will help identify people with smell loss after infection by sars-cov-2. we will use results from this test to better understand the relationship between sars-cov-2 infection and recovery of olfactory function and to learn whether the aromha longitudinal smell test is a reliable olfactory function tracking tool to quantify smell loss in the context of covid infection. these results may inform the design of therapeutic clinical trials to accelerate the recovery of smell function.


Eligibility criteria:
for anosmic patients/healthy controls: inclusion criteria 1. known anosmia (for anosmic patients only) 2. age greater than or equal to 18 3. access to phone, tablet or computer connected to the internet. exclusion criteria 1. known odor-evoked adverse effects, e.g. asthma. for asymptomatic participants: inclusion criteria 1. no symptoms of covid infection at the time of enrollment. 2. age greater than or equal to 18 3. access to phone, tablet or computer connected to the internet. exclusion criteria 1. known odor-evoked adverse effects, e.g. asthma. for participants with covid-19-related smell loss: inclusion criteria 1. past infection of sars-cov-2 virus as validated by a previous pcr or antigen test 2. age greater than or equal to 18 3. access to phone, tablet or computer connected to the internet. exclusion criteria 1. known odor-evoked adverse effects, e.g. asthma.
medication use among american indians adults

Conditions: Type 2 Diabetes; Medication Adherence

Summary: the goal of this study is to explore facilitators of and barriers to medication adherence within the context of local social determinants of health (sdoh) that are not available in the ehr. for american indians with type 2 diabetes. the main aim is: identify facilitators of and barriers to medication adherence within the context of sdoh, electronic health record (ehr) derived medication adherence \[hba1c \ 7% to ≤9% (above target); and hba1c \> 9% (uncontrolled)\].

the investigators will identify potential participants by drawing a sub sample of 90 patients from the larger sample (based on findings from aims 1 and 2). once patients are identified university of florida (uf) study team members will provide a coded list of eligible patients, from the limited dataset, to the choctaw nation of oklahoma (cno) information management team. the cno information management team will provide the contact information for 135 individuals directly to the cno community health worker who will then contact patients. uf study team members will not have access to the identifiable data. the cno community health worker (not uf study team members) will contact by telephone or in person at a scheduled visit the identified patients within each of the sampling groups (labeled 1-6) to introduce the study and screen for eligibility. after reviewing the consent, answering any questions, and obtaining written consent for the study, the cno community health worker will use a structured interview guide containing semi-structured and open-ended questions with probes to collect in-depth information from the patient. as part of the interview session patients will be asked to complete 3 sets of questionnaire items: demographic, sdoh, and medication and utilization. all interviews will be audio recorded and professionally transcribed and validated for accuracy. instead of using patient names cno will link each transcript back to the code number provided by the uf study team. the uf study team will not have access to the link of the code number to the patient identifier. the de-identified transcripts will be sent to uf study team members for analysis. a uf study team member will use a qualitative data management program to aid in analyzing and managing the data.

Eligibility criteria:
inclusion criteria: 1. enrolled tribal member 2. 18 years and older 3. have been diagnosed with type 2 diabetes 4. live within cnos 10.5 county service area 5. use cno tribal health services 6. for whom cardiometabolic levels and medication adherence level will have been generated from the aim 1 analysis of cno data 7. willing and able to participant in a 60-90-minute interview focused on facilitators of and barriers to medication adherence. exclusion criteria: (1) has end-stage renal disease

Keywords: type 2 diabetes medication adherence american indians barriers facilitators social determinants of health
characterization of factors influencing the cognitive decline in patients with coronary artery disease

Conditions: Coronary Artery Disease

Summary: the real impact of cardiac surgery and coronary angioplasty remains to be clarified and, where appropriate, the influencing factors in a way beneficial or deleterious remain to be identified. the identification of such factors could make even faster screening, prevention and therefore open therapeutic prospects for those patients. the objective of the study is to constitute a prospective cohort to assess the occurrence of cognitive decline after cardiac surgery (200 patients) and coronary angioplasty (200 patients) using the scale dementia rating scale (drs) of mattis. in addition, the investigators will identify factors that influence positively or negatively, the occurrence of such a cognitive decline. the study based on a systematic monitoring of clinical, biological, imaging and pharmacological factors and, to correlate the respective influence of these factors on the incidence of cognitive decline.

cardiovascular invasive interventions (surgery and angioplasty) save thousands of lives every year, but questions remain about the neurological complications and in particular cognitive deficit. indeed, cardiac surgery has been associated with cognitive decline in 50 to 70% of patients in the first postoperative week and in 20 to 40% of patients 6 months to one year after surgery. the study will be based on a prospective monitoring during 1 year of a cohort of 400 patients who will receive either a cardiac surgery or coronary angioplasty. at inclusion, will be collected medical history, risk factors, treatment history, clinical and etiological data (imaging, cardiac and vascular balance). the results of routine tests performed complementary to hospitalization will be recorded (echo-doppler vessels of the neck, cardiac ultrasound trans-thoracic and/or transesophageal a holter cardiac). in recruiting, we will apply a method of matching based on age (on 5 years) between 2 groups in order to compare 2 homogeneous groups.

Eligibility criteria:
inclusion criteria: * aged more than 18 years, * candidate to cardiac surgery or patients candidate to coronary angioplasty. exclusion criteria: * presenting a psychiatric illness that can interfere with the mental state and with scores provided in this study (explored in a systematic manner by the mini international neuropsychiatric interview dsm 4).

Keywords: cardiac surgery angioplasty cognitive decline
optimal treatment of plantar fasciitis: physical training, glucocorticoid injections or a combination thereof.

Conditions: Plantar Fasciitis

Summary: the purpose of this study is to determine whether reduced load to patients with plantar fasciitis (reduced standing, walking, landing) together with either controlled heavy resistance training or glucocorticosteroid injection or a combination thereof is the best treatment.

plantar fasciitis (pf) is a frequently diagnosed condition, defined as pain at the medial tubercle of the calcaneus, and 10% of the population will at some points in their life experience this condition. accumulated loading of the plantar fascia seems to relate to development of pf, as it is commonly seen in runners and those who are overweight, and number of daily steps or simply time of standing has been shown to be a predisposing factor for pf development. orthosis and glucocorticoid injections are 2 widely used treatments with proven effect. however treatment of overuse injury in other tendon/aponeurosis-like structures, has over the later years been dominated by an increasing documentation of a good curative effect of heavy controlled mechanical loading (eccentric strength exercises or heavy slow concentric strength training) upon tendinopathies in achilles or patella tendon. however, no studies have looked at the influence of physical training (e.g. strength training) on the diseased plantar aponeurosis. also no studies have looked at the effect of a combination of giving local glucocorticoid injection and training on this or other tendon overuse entities. we hypothesize that heavy strength training will have a positive effect upon pf, and that a combination of training and glucocorticoid injections will have an additive effect upon this disease and be even more effective than each of the treatments alone. glucocorticoid injection acting as the standard control treatment.

Eligibility criteria:
inclusion criteria: * pain at the medial attachment of fascia plantaris. * first step pain in the morning * symptoms for at least 3 months. * age 20-65 years * ultrasound scanning at the first visit shows thickness of the fascia above 4 mm. * patient can read and understand danish exclusion criteria: * known arthritis, inflammatory bowl disease, psoriasis or clinical signs of any of these * leg ulcerations * longlasting oedema of the leg and foot * palpatory decreased puls in the foot * diabetes * reduced sensibility in the foot * infections in the foot * daily use of pain killers * pregnancy or planning to become pregnant * earlier operations on the foot, that is judged to complicate training * patient assessed not to be able to participate in the training for other reasons * glucocorticosteroid injection to the diseased plantar fascia within the last 6 months.

Keywords: plantar fasciitis treatment training glucocorticosteroid injection
embedded narrative in interactive game design for improving medication adherence of schizophrenia

Conditions: Schizophrenia and Related Disorders; Medication Adherence; Mental Health Issue; Gamification

Summary: this study explores the potential of an interactive narrative game to enhance medication adherence among stable schizophrenia patients. employing participatory design methods, game's development and testing process actively involved patients and individuals closely connected to their daily lives. artificial intelligence-generated content (aigc) facilitated swift iterations in game's visual style and content. during game therapy, patients are tasked with making decisions based on presented situations, which influence the course of the narrative.

our game design is inspired by cognitive behavioral therapy (cbt), specifically the autonomic engagement and emotion regulation for the treatment of stable schizophrenic patients. this design aims to motivate patients to practice the basic principles of cbt in a virtual environment with the aim of producing positive psychological and behavioral changes in real life. to ensure that the interactive design in the game can effectively promote cognitive reconstruction and emotional regulation in patients, the investigators used the following game interaction strategies: 1. situational simulation: by simulating real-life situations, patients face challenges and make decisions in the game that are similar to those in real life, so as to train their cognitive and emotional regulation. 2. immediate feedback: provide patients with immediate feedback during the game so that they can understand the impact of their decisions on the outcome of the game, thus encouraging them to make more positive decisions in real life. 3. role-imitation: encourage patients to take an in-depth look at their thoughts and behaviors from a third-person perspective by having them take on the role of a therapy practitioner.

Eligibility criteria:
inclusion criteria: * stable phase schizophrenia * on long-term medication * medication adherence was problematic exclusion criteria: * serious schizophrenia * lack of basic cognitive abilities
the difference of reflux pattern between the patients who have postprandial reflux symptoms

Conditions: Gastroesophageal Reflux Disease

Summary: gastroesophageal reflux disease is increasing worldwide. the causes of reflux symptoms are not found exactly. especially, the postprandial reflux symptoms are more common than the all day reflux symptoms. one of the causes of reflux symptoms is the relaxation of the lower sphincter of the esophagus. but, the sphincter relaxation also occur in normal people. but, there is a difference in postprandial reflux pattens between the patients and the normal people. so, in this study, we want to compare the difference of reflux pattern between the patients who have postprandial reflux symptoms and normal people though the 24hr ph monitoring.


Eligibility criteria:
inclusion criteria: 1. over 19 years old, male and female 2. normal people (control group, who has no postprandial reflux symptoms 3. patients who have postprandial reflux symptoms (postprandial reflux symptom means that within the last 6 months, postprandial reflux symptoms more than once a week for more than 1 month) exclusion criteria: 1. patients who have nasoesophageal stricture 2. patients who have bleeding tendency 3. patients who have esophageal varix 4. patients who have cardioverter implantation 5. patients who had surgery for esophagus, stomach or duodenum 6. patients who are taking medications, gastrointestinal motility drugs
patient knowledge on pain management and safe opioid use

Conditions: Opioid Use

Summary: the purpose of this study is to examine what patients currently know about opioids, including their role in pain management, side effects, risks of abuse, and proper storage and disposal. it is critical for patients to be properly informed about opioid usage in treating postoperative pain, but current gaps in patient knowledge are not well understood. this study will help identify knowledge deficiencies and guide future patient education. additionally, this study will examine possible patient factors that may be associated with these gaps. evaluation of patient knowledge will be assessed through interviews conducted before patients' day of surgery.

opioids are frequently prescribed to treat pain after surgery, and while these medications may be effective analgesics they are also susceptible to misuse and addiction. there are growing concerns that prescription opioids contribute to the existing opioid supply and become potential sources for abuse1,2. in fact, opioids are often abused by those using medications not prescribed to them but obtained from friends or relatives3,4. many patients who undergo surgery are not given adequate information about opioids and strategies for postoperative pain management. studies find that inadequate knowledge and inability to recall postoperative pain regimens result in poor compliance5. many patients are also unaware of how to properly store and dispose of prescription opioids1,6 and this predisposes them to opioid misuse and improper saving and sharing of pills6. little is known, however, about the specific gaps in knowledge and what patient demographics may be associated with lack of understanding. as an initial step toward addressing these issues, this study seeks to identify deficiencies in patient understanding of opioids and pain management.

Eligibility criteria:
inclusion criteria: * age range between 18 and 80 years old * undergoing primary total hip replacement surgery * english speaking exclusion criteria: * medical background (profession that involves the prescribing, dispensing, handling, or administering of opioids) * history of chronic opioid use (continuous opioid use for 3 or more months) * opioid use within the past 3 months * non-english speakers
comparison of the effectiveness of two glucocorticoid regimens for treatment of graves' orbitopathy

Conditions: Graves Ophthalmopathy

Summary: the goal of this interventional study is to compare the effectiveness of two different glucocorticoid regimens for treatment of active moderate-to-severe graves' orbitopathy. the main questions it aims to answer are: 1. are the two glucocorticoid regimens similarly effective? 2. do the two glucocorticoid regimens have similar safety profile? the patients involved are treated with one of the two glucocorticoid regimens. their ocular status, therapeutic response and quality of life reassessed during the treatment, at its end, and 3 month later.

systemic glucocorticoids are the mainstay of treatment for active moderate-to-severe graves' orbitopathy. however, there are a number of different glucocorticoid regimens with different total dosage, schemes of administration and duration. the goal of this interventional study is to compare the effectiveness of two different glucocorticoid regimens for treatment of active moderate-to-severe graves' orbitopathy. the main questions it aims to answer are: 1. are the two glucocorticoid regimens similarly effective? 2. do the two glucocorticoid regimens have similar safety profile? the patients involved are treated with one of the two glucocorticoid regimens. the first group is treated with modified monthly regimen, including 3 pulses of 3 infusions of 500 mg methylprednisolone administered in three consecutive months, with application of 125 mg methylprednisolone intramuscularly once per week between the pulses. total cumulative dose - 5.5. g., duration - 3 months. after completion of the venous infusions, a low dose peroral glucocorticoid therapy is prescribed for the next 3 months. the second group is treated with weekly glucocorticoid regimen: 6 infusions of 500 mg methylprednisolone during the first 6 weeks followed by 6 infusions of 250 mg methylprednisolone during the next 6 weeks. total cumulative dose - 4.5 g., duration - 3 months. patients' ocular status and therapeutic response are assessed at 1st, 3rd and 6th months; quality of life - at 3rd and 6th month.

Eligibility criteria:
inclusion criteria: * active moderate-to-severe graves' orbitopathy * without previous treatment with glucocorticoids or orbital radiotherapy * euthyroid state exclusion criteria: * uncontrolled hyper- or hypothyroidism * previously treated graves' orbitopathy * mild or sight-threatening form of graves' orbitopathy * inactive moderate-to-severe graves' orbitopathy * contraindications for glucocorticoid treatment
risk factors for poor outcome after epigastric and umbilical hernia repair

Conditions: Umbilical Hernia; Epigastric Hernia

Summary: umbilical and epigastric hernia repairs are common and performed by numerous surgical techniques. considering that the hernia repairs in general are relatively small and simple procedures there are disproportionate poor results. the aim of present study is to determine surgical risk factors for readmission after umbilical and epigastric hernia repair and to report risk factors for later reoperation for recurrence.

all elective umbilical or epigastric hernias registered in the danish ventral hernia database are included in the study. the included patients will be followed in up to 4 years in order to identify correlation between technical aspects of the hernia repair and postoperative morbidity.

Eligibility criteria:
inclusion criteria: * umbilical or epigastric hernia repair exclusion criteria: -

Keywords: readmission recurrence umbilical epigastric hernia outcome morbidity