Kornimate/medical-research-clean huggingface dataset:
feasibility and effectiveness of a pilot program of physical activity to improve hiv related functional limitations and disability in adults aged 40 and older from côte d'ivoire

Conditions: HIV Infections

Summary: the goal of this interventional study is to document the importance of hiv-related disabilities, notably the frequency / nature of functional limitations, neurocognitive impairments, and restrictions of social participation in adults living with hiv aged 40 and older. participants will undergo a comprehensive set of cognitive and functional assessments, and approximately twenty particpants will be asked to participate in an anthropological survey conducted through structured interviews. researchers will a group of people living with hiv and o reference group without hiv infection.

this is a mixed-methods study combining a cross-sectional study during which clinical evaluations, functional tests, and quantitative evaluations by questionnaire relating to disability (whodas, hdq), depression (phq-9) will be conducted. and an anthropological survey. the study takes place in the abobo district, abidjan, in two health centers. the quantitative evaluation will concern 300 people living wiht hiv (plhiv) receiving antiretroviral therapy and followed at the avocatier health facility (fsu) and the el rapha medical health centre (cms), in the abobo district, abidjan. a comparison group of adults without hiv infection of similar sex and age distribution will also be included as a reference group (n = 150). the qualitative research will include around 20 plhiv selected so that enough diversity is represented (sex, age, family situation). it will be based on conducting interviews to examine how the practice of physical activity is perceived culturally and socially and to determine the factors that may influence the implementation of this type of activity.

Eligibility criteria:
inclusion criteria: participants living with hiv: * age ≥40 years * documented hiv-infection * combined art for ≥12 months * written consent to participate to the study controls: * age ≥40 years * negative hiv test within the last 12 months; * living in abobo area * written consent to participate to the study exclusion criteria: participants living with hiv: * hiv infection with hiv-2 type only * any clinical symptoms suggesting an acute infection * any life-threatening pathology in the short term or any pathology not allowing participation in the study controls: * any clinical symptoms suggesting an acute infection * any life-threatening pathology in the short term or any pathology not allowing participation in the study

Keywords: hiv disabilities aging readaptation resource-limited countries
efficacy of therapeutic interventions for orthostatic hypotension in parkinson's disease and multiple system atrophy

Conditions: Parkinson's Disease; Multiple System Atrophy; Orthostatic Hypotension

Summary: patients with parkinson's disease or multiple system atrophy (msa), and symptoms of orthostatic hypotension, are eligible for the study. each patient will have three weeks of conservative therapy, three weeks of therapy with fludrocortisone, and three weeks of therapy with domperidone. autonomic testing, a symptom questionnaire, bedside blood pressure testing, and unified parkinson disease rating scale (updrs) will be performed after each intervention.

enrolled patients, ages 40-95, must have parkinson's or msa, diagnosed by a neurologist, and symptoms of orthostatic hypotension. each patient will fill out two validated questionnaires to determine if they are candidates for the study. baseline patient details, such as their medications and updrs, will be recorded. medications must be held stable during the period of the study. each patient will then have three weeks of conservative therapy, three weeks of therapy with fludrocortisone, and three weeks of therapy with domperidone. autonomic testing, a symptom questionnaire, bedside blood pressure testing, and updrs will be performed after each intervention.

Eligibility criteria:
inclusion criteria: * patients residing in queensland australia * age 40-95 * parkinson's disease or msa diagnosed by a neurologist * symptoms of orthostatic hypotension, as defined by 2 validated questionnaires exclusion criteria: * patients with acute cardiomyopathy or cardiac condition * patients unable to give consent * patients not stable on their parkinsonian medications * patients with another cause for autonomic neuropathy

Keywords: orthostatic hypotension parkinson's disease
laser doppler flowmetry in assessing the vitality of traumatised teeth

Conditions: Dental Trauma

Summary: teeth injuries are considered one of the most challenging events that occur in dentistry, especially in children. after an injury, there is a possibility that the blood supply to the tooth may become affected and compromised leading to nerve and blood vessels death with the tooth described as a non-vital tooth. the conventional diagnostic tools available to assess tooth nerve/blood supply are not always reliable. child cooperation and understanding contribute greatly to this shortfall. failure to assess the vitality of the tooth may result in pain, swelling or infection of the tooth or de-vitalising a normal tooth which may render the tooth weak for the future and possibly losing the tooth. the laser doppler flowmetry is a non-invasive, non-painful technique and shown to be more reliable than the traditional techniques. we aim to assess if this device can predict and assess whether the tooth is alive or dead during the follow up visits of the injury along the other conventional tests.

a clinical study will be carried out which consists of a one year follow up to monitoring traumatised front teeth in children attending the department of paediatric dentistry. the vitality/sensibility of traumatised teeth will be assessed using laser doppler flowmetry, electrical pulp testing and ethyl chloride. measurements will be performed by a single operator (chief investigator) and will be carried out at baseline, 3, 6, 9 and 12 months follow up period.

Eligibility criteria:
children would be recruited into this study when they: * between 6-16 years old. * medically fit (asa i, ii). * able to communicate using english language. * have an acceptable level of cooperation. * have at least one traumatised anterior tooth, regardless of the type of trauma, with uncertain pulpal vitality requiring monitoring for a minimum of 12 months and minimal coronal restoration (covering less than half the labial crown surface). * have at least one vital and non-traumatised anterior tooth to act as a control. exclusion criteria: * medically and mentally compromised children. * children with learning disabilities. * children with communication barrier including those unable to communicate using english language. * heavily restored teeth covering more than half the labial surface of teeth. * patients on routine analgesics, antidepressants or antihypertensive drugs. * vital teeth with pulp canal obliteration.
awareness of gestational diabetes among sohag governorate women

Conditions: Gestational Diabetes

Summary: the type of the study is a cross sectional descriptive using questionnaire method in sohag governorate among 500 women, over 6 months by random selection and they will be asked to answer the questions of prepared and copied questionnaire sheet. inclusion criteria: all women can participate in this questionnaire.

the study is a cross sectional descriptive using questionnaire method in sohag governorate among 500 women, over 6 months by random selection and they will be asked to answer the questions of prepared and copied questionnaire sheet. data was collected by using a self-administered questionnaire. based on extensive literature review no questionnaire was found that specifically related to knowledge evaluation. the basic theme of the questionnaire was taken from diabetes knowledge questionnaire (dkn), a well validated tool for knowledge assessment among type 1 and type 2 diabetes mellitus patients. some modifications were made and new questions particularly related to gestational diabetes mellitus (gdm) were included. final version of questionnaire consists of 15questions divided into five main categories which are basic knowledge about gdm(3 questions), risk factors (3 questions), food and diet values (3 questions), management(3 questions)and complications/outcomes (3 questions). all questions were in multiple choice format with one option was "i don't know "to avoid unnecessary guesses by the participants. score 1 was given to every right answer and 0 to every wrong answer. a higher score indicates better knowledge about gdm. thus the maximum score is 15 and minimum is 0 and other questions without score to know the patient himself and to assess the relationship between the residency, work, education level and knowledge of patient and family history. a standardized questionnaire will focus on: 1. personal data 2. basic knowledge about gdm 3. knowledge about risk factors of gdm 4. knowledge about diet/food values 5. knowledge about management of gdm 6. knowledge about gdm complications/outcomes

Eligibility criteria:
inclusion criteria: * all females exclusion criteria: * there is no exclusion criteria:
effect of spontaneous breathing on atelectasis during induction of general anesthesia in patients in infants

Conditions: Atelectasis

Summary: spontaneous breathing on occurrence of atelectsis in infants

keeping the spontaneous breathing during the anesthesia for 5 minutes and occurrence of atelectasis

Eligibility criteria:
inclusion criteria: * general anesthesia exclusion criteria: * heart or lung problems * prematurity
a research study of how semaglutide works in people with disease affecting the heart and/or blood vessels and type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: this study looks into how the type 2 diabetes medicine, semaglutide, can prevent risk of heart disease complications and stroke. participants will either get semaglutide or placebo ("dummy" medicine) - which treatment is decided by chance. semaglutide is a new medicine to treat type 2 diabetes and can be prescribed by doctors in some countries. the study medicine will be in a pen, and must be injected with a needle in the stomach, thigh or upper arm once a week. the study will last for 57-63 weeks. participants will have 10 clinic visits with the study doctor, 5 visits to the specialised clinic for imaging and at least 1 phone contact. participants' health will be monitored carefully and blood samples will therefore be taken at the clinic visits. women cannot take part if pregnant, breast-feeding or planning to become pregnant during the study period.


Eligibility criteria:
inclusion criteria: * male or female, age above or equal to 50 years at the time of signing informed consent * body mass index equal to or less than 39.9 kg/m\^2 * diagnosed with type 2 diabetes 180 daysor more prior to the day of the first screening visit * hba1c 6.0% - 9.0% (42-75 mmol/mol) (both inclusive) * established cardiovascular disease exclusion criteria: * hospitalisation for unstable angina pectoris or transient ischaemic attack within 90 days prior to the day of the first screening visit * planned coronary, carotid or peripheral artery revascularisation. * presently classified as being in new york heart association (nyha) equal to or above class iii * treatment with glucagon-like peptide-1 receptor agonists (glp-1 ras) or systemic anti-inflammatory drugs within 90 days prior to the first screening visit. stable treatment with acetylsalicylic acid for prevention of cardiovascular events and occasional use of propionic acid derivatives drugs (e.g. ibuprofen) is allowed
reperfusion with cooling in cerebral acute ischemia

Conditions: Stroke, Acute

Summary: the purpose of this study is to determine whether reducing a patients body temperature (mild hypothermia of 33 degrees centigrade) will significantly reduce the risk of brain injury (notably reperfusion injury and hemorrhagic conversion) in patients that have suffered a significant interruption of blood flow to an area of brain (occlusion of large proximal cerebral artery) and have undergone successful removal of that interruption (revascularization).


Eligibility criteria:
inclusion criteria: * age 18-85 years old * symptoms consistent with an ischemic stroke with a large vessel occlusion (mca, ica-terminus) as determined by vascular imaging * aspects score of 5-7 on non-contrast ct of the brain * ability to undergo endovascular reperfusion therapy * must have no contraindications to general anesthesia * a pre-treatment modified rankin score of 0 or 1 * arterial puncture performed under 8 hours from symptom onset or last seen normal * immediate post reperfusion ct scan shows no hemorrhage exclusion criteria: * bleeding diathesis with a platelet count \ 1.5 * involved in another clinical trial * history of dementia * end stage renal disease on hemodialysis * history of ventricular dysrhythmias * life threatening medical condition precluding survival under 6 months * presence of an ivc filter * contrast dye allergy with history of anaphylaxis

Keywords: ischemic stoke endovascular reperfusion reperfusion injury mild hypothermia
tcm etiological study on the theory of xusunshengji in liver cirrhosis

Conditions: Liver Cirrhosis

Summary: to elucidate and confirm the theory of xusunshengji in the traditional chinese medicine etiological pathogenesis of liver cirrhosis.


Eligibility criteria:
inclusion criteria: * with 6 month of chronic liver disease history, and positive serum hbsag exclusion criteria: * other chronic hepatitis and liver cirrhosis of non-hepatitis b
safety and efficacy assessment of unani formulation 'dolabi' in management of diabetes mellitus type ii

Conditions: Diabetes Mellitus; Type 2 DM

Summary: diabetes is a chronic health condition that affects millions of people worldwide. in recent years, pakistan has witnessed a significant increase in the prevalence of diabetes, making it a major public health concern. to address this growing problem, conducting clinical trials on diabetes in pakistan is of utmost importance. clinical trials play a crucial role in advancing medical knowledge, improving patient care, and finding effective treatments for diabetes. this research aims to assess the safety and effectiveness of the unani formulation dolabi in treating type ii diabetes mellitus. the study consists of two phases: a pre-clinical phase, which involves acute and subacute oral toxicity testing on animal models, and a clinical phase, which includes a single-blind, single-arm, multicenter, phase ii clinical trial conducted at shifa ul mulk memorial hospital-hamdard university and haidery herbal care-north nazimabad to evaluate its clinical efficacy. diabetes management plays a vital role in effectively controlling the disease and minimizing its complications. lifestyle management plays significant role in managing blood glucose levels in all age and gender segments. medications are prescribed to regulate blood glucose levels when lifestyle changes alone are insufficient. regular monitoring of blood sugar levels, along with other important parameters like blood pressure and cholesterol, helps individuals with diabetes to track their progress and make necessary adjustments to their treatment plans. dolabi is a time tested formulation of hlwp and it is being used clinically for more than 05 years at hamdard matabs all around pakistan and clinically found satisfactory. the current study is designed in accordance with ich gcp e6 protocols as approved by who and drap. it will enable us to present this safer and locally produced combination for the large community suffering with this condition in improving their lives.


Eligibility criteria:
inclusion criteria: * subjects having type ii diabetes mellitus. * subjects having raised fbs above 120 mg/dl and hba1c level 6.7 or above. * subjects over 30 years of age. * subjects agree to use study medicine throughout the study. exclusion criteria: * subjects suffering from chronic liver diseases and kidney failure. * subjects currently taking any hypoglycemic agent(s). * subjects suffering from any type of cancer and any other comorbid condition. * subjects having history of adverse drug reaction. * pregnant and lactating mother.

Keywords: diabetes mellitus t2dm metabolic disease insulin resistance
intaglio surface of full-arch implant supported prosthesis

Conditions: Peri-Implantitis

Summary: the purpose of the study is to determine if there is an association between the intaglio shape of full-arch implant-supported prosthesis and marginal bone level around implants. the intaglio shape can be present as concave or convex and, depending on that, it can lead to more plaque accumulation on the fitting surface of the prosthesis. null hypothesis (h0): full-arch implant supported prosthesis with an increased depth of the intaglio shape demonstrate similar marginal bone levels as prosthesis with a reduced depth of the intaglio surface. alternative hypothesis (h1): full-arch implant supported prosthesis with an increased depth of the intaglio shape demonstrate increased/reduced marginal bone levels compared to prosthesis with a reduced depth of the intaglio surface.

the investigators will review dental records from the university and call eligible individuals for an appointment. during the research visit, the investigators will take new x-rays for marginal bone level assessment and a digital scan of the prosthesis to assess the shape of the intaglio. also, remove the prosthesis, perform clinical measurements and collect plaque samples from the prosthesis and the implant sulcus. then, implants and prosthesis will be cleaned and placed in position. the study will have only one appointment where every measurement will be assessed in this visit.

Eligibility criteria:
inclusion criteria: * ≥ 18 years old; * rehabilitated with a full-arch screw-retained supported prosthesis in the maxilla, in function for at least 1 year; * good overall health (asa i or asa ii). exclusion criteria: * individuals with motricity problems who cannot clean the prosthesis; * patients treated or maintained in centers outside the university of pittsburgh; * incomplete dental records; * misfit at the prosthesis-implant interface; * cemented prosthesis; * individuals rehabilitated with over dentures; * individuals with uncontrolled chronic diseases or immunocompromised; * pregnant patients.

Keywords: peri-implantitis marginal bone level dental implants full-arch prosthesis hybrid prosthesis
rb liquid biopsy biorepository

Conditions: Retinoblastoma; Retinoblastoma Bilateral; Retinoblastoma Unilateral

Summary: retinoblastoma (rb) is a primary eye cancer that forms in the back of the eye of infants and toddlers. traditionally, rb is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed. given this limitation, we use aqueous humor (ah), the clear fluid in the front of the eye to detect specific markers, or information, that comes from the tumor itself.

retinoblastoma (rb) is a primary intraocular malignancy that forms in the retina of infants and toddlers. traditionally, rb is diagnosed without tissue as direct tumor biopsy is prohibited due to risk of extraocular spread; tissue can only be obtained once an eye has been surgically removed. given this limitation, there are no eye-specific molecular biomarkers in current clinical practice for rb. the lack of in vivo molecular data without removing the eye limits our ability to prognosticate clinical outcomes and develop personalized treatment plans. it also limits our understanding of intratumoral dynamics throughout therapy. the aqueous humor (ah) is a high-yield source of tumor-derived nucleic acid that can be utilized as a liquid biopsy in eyes with retinoblastoma. detection of biomarkers from the ah may be used to prognosticate the likelihood of eye salvage and in the future may facilitate targeted, patient-centered therapies based on molecular biomarkers. objectives: 1. systematically and prospectively record accurate and complete data regarding the clinical presentation, treatment, and outcomes of patients diagnosed with rb. 2. collect, bank, preserve, and analyze biomaterials including ah, blood and saliva from patients with rb. 3. correlate phenotypic data with genotypic findings from human biomaterials in retinoblastoma patients to identify clinically relevant biomarkers

Eligibility criteria:
inclusion criteria: * all patients, age 0 days to 18 years, with a diagnosis unilateral or bilateral retinoblastoma (rb) seen at chla (children's hospital los angeles). exclusion criteria: * patients referred for second opinions only and not treated at chla for any reason.

Keywords: retinoblastoma rb ocular oncology aqueous humor
vytorin (10/20 or 10/40) compared to atorvastatin (10 mg or 20 mg) in patients with coronary artery disease (0653a-126)(completed)

Conditions: Hypercholesterolemia

Summary: evaluate the proportion of hyperlipaemic persons with known coronary heart disease achieving ldl-c goal as defined by the national cholesterol education program (ncep) adult treatment panel (atp) iii guidelines


Eligibility criteria:
inclusion criteria: * patients who are naïve to lowering lipid agent * patients who are treated with lowering lipid agents and had a wash-out period for 4 weeks. exclusion criteria: * impaired kidney function * increased liver enzyme levels * pregnant women * hypersensitivity to ezetimibe and other statin agents

Keywords: hypercholesterolaemia