Kornimate/medical-research-clean huggingface dataset:
safety and efficacy of cem-102 compared to linezolid in acute bacterial skin infections

Conditions: Skin Diseases, Bacterial

Summary: the purpose of this study is to determine the safety and efficacy of cem-102 compared to linezolid in the treatment of acute bacterial skin structure infections (abssis).

abssis are common and affect all age groups. in recent years, abssis caused by multi-drug resistant pathogens, especially methicillin-resistant staphylococcus aureus (mrsa) have become more common. there is an urgent need for additional antibacterial drugs with modes of action different from those currently available. cem-102 is one such agent with excellent activity against s. aureus, including mrsa.

Eligibility criteria:
inclusion criteria: * diagnosis of acute bacterial skin-structure infection (abssi) of no more than 7 days duration which was suspected or proven to be caused, at least in part, by a gram-positive pathogen. * eligible infections included cellulitis measuring at least 10 cm length and width or 100 cm squared, with or without a focal abscess, and surgical or traumatic wound infections * infection which in the opinion of the investigator will require 10-14 days of antibacterial therapy. * have at least 3 of the following local and/or systemic symptoms and/or signs of infection: purulent or seropurulent drainage/discharge, erythema, fluctuance, heat/localized warmth, pain/tenderness to palpation, swelling/induration, regional lymph node swelling or tenderness, temperature \>=100.4 degree f, increased white blood cell count, or bandemia. * must not have received treatment with another systemic antibiotic for the current abssi. exclusion criteria: * superficial skin structure infections such as folliculitis, carbuncles, furunculosis, cutaneous abscesses, and simple cellulitis. * infections involving burns, human or animal bites, or chronic diabetic foot ulcers. * suspected polymicrobial infection involving pseudomonas aeruginosa * anticipated need for \>14 days of antibiotic therapy. * infections complicated by the presence of prosthetic materials that will not be removed, such as permanent cardiac pacemaker battery packs, mesh, or joint replacement prosthesis. * known significant renal, hepatic, or hematologic impairment. * received prior potentially effective antimicrobial therapy for the acute bacterial skin and skin structure infection, unless they were failing therapy after 48 hours or had a gram-positive pathogen non-susceptible to prior therapy identified as a causative pathogen.

Keywords: acute bacterial skin and skin struction infections; bacterial skin diseases; staphylococcal skin infections; mrsa
comparative effects of perindopril and zofenopril on blood pressure control and oxidative status blacks hypertensive patients.

Conditions: Hypertension

Summary: the aim of the study is to compare the short term effect of perindopril and zofenopril in the management of hypertension and the oxydative stress in blacks hypertensive patients. pezo-hp is a double-arm, double-blind, randomized and parallel clinical trial conducted at the yaoundé central hospital.

aim: to determine and compare the short term effect of angiotensin converting in the management of hypertension as well as the oxidative effect of zofenopril and perindopril in blacks hypertensive patients in the yaoundé central hospital. method: a double-arm, double-blind, randomized and parallel clinical trial conducted at the yaoundé central hospital. hypertensive patients who are not taking angiotensin-converting enzyme inhibitor or angiotensin receptors blockers, are randomize into 2 groups. depending on the group, the intervention consisted of the administration of perindopril 10 mg daily or zofenopril 30 mg daily for 08 weeks. the endpoints were the nycthemeral blood pressure profile, pro oxidant marker (malondialdehyde) and anti-oxidant marker (ferric reducing antioxidant). progress: recruitment for pezo-hp was completed in may 2019 with 24 patients.

Eligibility criteria:
inclusion criteria: * hypertensive patients * on a stable atihypertensive therapies (determined by the investigator) for at least 3 months with no classes changes. the pharmacological treatment should not include an angiotensin-converting enzyme inhibitor or angiotensin ii receptor blocker * subject must not present any contraindication to exercise * before any study-specific procedure, the appropriate written informed consent must be obtained. exclusion criteria: * side effects affecting life quality of patients (determined by the data safety monitoring board). * withdrawal of consent

Keywords: angiotensin converting enzymes inhibitor angiotensin ii receptor blockers blood pressure oxidative status
effects of zolmitriptan on sensory transmission after spinal cord injury

Conditions: Spinal Cord Injuries; Muscle Spasticity

Summary: after spinal cord injury, patients develop a spastic syndrome that is characterized by hyperactive reflexes, increased muscle tone, clonus and involuntary muscle spasms. the neuronal mechanisms behind the development of spasticity remain largely unknown, though animal experiments have shown that changes occur both at the level of the motoneuron and sensory neurons. this project aims to examine the changes that occur in the modulation of sensory afferent transmission after spinal cord injury, and how these changes can contribute to the triggering and initiation of muscle spasms after chronic spinal cord injury in humans. it is known that after spinal cord injury, the majority of descending sources of monoamines, such as serotonin (5ht), are abolished. animal experiments have shown that 5ht receptors on sensory neurons in the spinal cord are responsible for inhibiting sensory transmission. as a result, after spinal cord injury these receptors are no longer activated below an injury, resulting in the production of large, long excitatory responses in the motoneuron when sensory are activated. this large sensory activation of the motoneuron can, in turn, activate a long response in the motoneuron to produce an involuntary muscle spasm. the aim of our study is to determine whether, similar to animal experiments, the 5ht1 receptors are responsible for sensory inhibition in spinal cord injured subjects, and whether activating these receptors (through the 5ht1 agonist zolmitriptan) will restore the normal inhibition of sensory transmission that is lost after injury, thereby resulting in a decrease in the initiation of involuntary muscle spasms.


Eligibility criteria:
inclusion criteria: * patients must have suffered a trauma to the spinal cord at least 1 year prior. in addition, subjects must exhibit some degree of spasticity as determined by having an ashworth spasticity score greater than 1 in the ankle or knee. exclusion criteria: * if patients have damage to the nervous system other than to the spinal cord * pregnant women * elderly patients (\> 65 years) * alcoholic patients * history of ischemic cardiac, cerebrovascular or peripheral vascular syndromes * valvular heart disease or cardiac arrhythmias * other significant underlying cardiovascular disease (atherosclerotic disease, congenital heart disease) * uncontrolled or severe hypertension * hemiplegic, basilar or ophthalmologic migraine * hypersensitivity to zolmitriptan or any component of the formulation * history of autonomic dysreflexia * patients taking: * ergot-containing drugs * other 5ht1 agonists * mao inhibitors * cimetidine and other 1a2 inhibitors * propranolol * selective serotonin and norepinephrine reuptake inhibitors * acetaminophen * metoclopramide * xylometazoline * oral contraceptives

Keywords: spasticity spinal cord injury zolmitriptan
capnographic monitoring in gastrointestinal endoscopy for elderly patients

Conditions: Hypoxia; Gastric Cancer; Gastric Polyp; Colon Polyp; Colon Cancer; Esophageal Cancer

Summary: hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people. the aim of this randomized study was to determine whether intervention based on additional capnographic monitoring reduces the incidence of hypoxia in gastrointestinal endoscopes procedures for elderly patients.


Eligibility criteria:
inclusion criteria: * 65 ≤ age \<80 * patients undergoing gastrointestinal endoscopes * patients signed informed consent form * asa classification i-ii exclusion criteria: * coagulation disorders or a tendency of nose bleeding * an episode/exacerbation of congestive heart failure (chf) that requires a change in medication, diet or hospitalization from any cause in the last 6 months * severe aortic stenosis or mitral stenosis * cardiac surgery involving thoracotomy (e.g., coronary artery bypass graft (cabg), valve replacement surgery) in the last 6 months * acute myocardial infarction in the last 6 months * acute arrhythmia (including any tachycardia - or bradycardia) with the fluid of hemodynamics instability * diagnosed chronic obstructive pulmonary disease or current other acute or chronic lung disease requiring supplemental chronic or intermittent oxygen therapy) * pre-existing bradycardia (heart rate \< 50 / min), or hypoxia (sao2\< 90 % ) * need supplemental oxygen because of pre-existing diseases * emergency procedure or surgery * multiple trauma * upper respiratory tract infection * allergy to propofol or tape and adhesives

Keywords: capnographic monitoring hypoxia gastrointestinal endoscopy elderly patients propofol
allium sativum oil and turmeric gel as alternative non-vital pulpotomy medicaments in primary teeth.

Conditions: Non Vital Teeth

Summary: the purpose of the study is to use allium sativum oil and turmeric gel as non-vital pulpotomy medicaments in primary teeth by evaluating their antibacterial effect against streptococcus mutans and lactobacillus acidophilus. it is hypothesized that there is no difference in the antibacterial effect of allium sativum oil and turmeric gel when used as non-vital pulpotomy medicaments.

it is a multi-arm parallel randomized controlled trial in which forty patients aged between 4 to 8 years, each containing at-least one non-vital primary molar, will be selected and randomly divided into group a (allium sativum oil) and group b (turmeric gel). non-vital pulpotomy will be performed by removing the coronal necrotic pulp. sterile paper point will be dipped in the root canals and taken to the laboratory. cotton pellets soaked in the respective medicaments will be placed over the root canal orifices and filled temporarily. patients will be recalled after one week. samples will be again taken, and tooth restored. comparison between bacterial count at baseline and after one week of treatment will be made and expressed as colony-forming units/ml (cfu/ml).

Eligibility criteria:
inclusion criteria: 1. cooperation of patients and consent of parents. 2. patients with asa classification i and ii (mild to moderate systemic disease). 3. non-traumatic extensively carious hence restorable primary molars. 4. no history of antibiotic use for 2 weeks. 5. presence of following clinical signs or symptoms suggestive of nonvital tooth such as tenderness on percussion, non-responsive to cold test, periapical/furcal radiolucency, localized gingival/mucosal soreness/ redness/ swelling, and/or slight mobility-grade i. exclusion criteria: 1. history of allergy to anesthetics and latex. 2. radiographic evidence of pulpal floor opening into the furcation area 3. more than half of the roots resorbed.
predictability of the pulse pressure variation (ppv) during spontaneous ventilation on the incidence of hypotension during induction of anesthesia

Conditions: Hypotension

Summary: the purpose of this study is to find out the predictability of the pulse pressure variation during spontaneous ventilation on the incidence of hypotension during induction of anesthesia.


Eligibility criteria:
inclusion criteria: * patients undergoing general anesthesia induction with intravenous anesthesia using propofol and remifentanil * patients requiring invasive arterial blood pressure monitoring for the surgery exclusion criteria: * refusal of consent * patients with heart disease (symptomatic valvular heart disease, intracardiac shunt, pulmonary hypertension with pulmonary systolic arterial pressure exceeding 40mmhg) * fev1 ≤ 50% predicted fev1 * patients with chronic renal failure * asa class iv, v, vi * systolic arterial blood pressure below 90mmhg before induction of anesthesia

Keywords: hypotension during anesthesia induction
prospective trial on trochanteric femur fractures treated with or without a trochanter support plate

Conditions: Femoral Fractures

Summary: fractures just below the hip often are treated with a so called gliding screw and plate (dhs). recently a new additional plate called a trochanter support plate (tsp) which attaches to the dhs has become available which is claimed to give extra support to the fracture. in a prospective randomised study we wish to test the hypothesis that the tsp does not give any additional stability to the fracture treated with the dhs.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of unstable trochanteric femur fracture.(evans-jensen class.3-5) * (can include; patients with cognitive problems (ie. dementia etc) exclusion criteria: * patients with pathological fractures * multitrauma patients * patients not able to walk before the fracture * under 19 years old. * patients with fractures needing other treatments than gliding hip screws * reverse oblique fractures.

Keywords: trochanter femur fracture
collaborative outcomes study on health and functioning during infection times during covid-19 pandemic

Conditions: Mental Health Wellness 1; Pandemic

Summary: observational, cross-sectional, multi-center, multi-wave survey, assessing characteristics and predictors of physical and mental health as well as health behaviors during covid-19 pandemic, targeting the general population (children, adolescents and adults).

in march 2020, the world health organization declared the covid-19 (known as coronavirus) virus a global pandemic. covid-19 is a variant of coronavirus thought to originate in wuhan province china. up until april 7, 2020, as many as 1,346,299 individuals had confirmed covid-19 infection, with already 74,679 deaths from covid-19 complications. the hypothesis of this study is that the physical and mental health of the general population and health care workers involved in the management of covid-19 infected people is heavily affected by covid-19, but that risk and protective factors exist. investigators plan to distribute 3 different surveys based on the age group. the first survey, coh-fit-adults/ (coh-fit-a), will be distributed the general adult (age \>/= 18 years old) population in north america, south america, europe, asia, africa and australia via an online link, making the general population aware of the project via public announcements, social media and regular media coverage outlets, or via specialized institutes and agencies (e.g., opinion research centers) that are capable of using a randomly selected, nationally representative sample (potentially funded by national / local grant applications). for the subgroup of adult health-care professionals, additionally, survey distribution mechanisms will be used that utilize medical professional organizations and associations, hospital and university anonymized channels. guardians of adolescents aged 14-17 years old will be asked to provide electronic consent for their adolescent to participate in the coh-fit-ad survey after having taken the survey and being familiar with the questions, being informed that the one question having sexuality as the content will be omitted from the adolescent version. guardians of children aged 6-13 years old will be able to review the survey questions that children would answer before electronically consenting to participate.

Eligibility criteria:
inclusion criteria: * general population * consenting to the study (adults) * guardians consenting to study participation of children and adolescents exclusion criteria: * not consenting to the study (adults) * not assenting to the study (children and adolescents) * age \< 6 years old

Keywords: covid-19 mental health physical health infection resilience
cbt with disulfiram and contingency management

Conditions: Cocaine Abuse

Summary: this is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. all participants will receive weekly individual cognitive behavioral therapy (cbt).

this study will compare four types of treatment involving skills training and incentives for attending sessions or taking study medication. disulfiram is a widely prescribed deterrent to alcohol use. in addition to weekly cognitive behavioral therapy (cbt), participants will be assigned to one of the following treatments: 1. placebo 2. disulfiram 3. placebo plus incentives for cocaine abstinence and medication compliance (prize cm) 4. disulfiram plus incentives for cocaine abstinence and medication compliance

Eligibility criteria:
inclusion criteria: * 18-50 year old * cocaine dependent * willing to sign consent * willing to accept randomization to intervention exclusion criteria: * significant medical conditions * psychiatric disorder with current use of prescribed psychotropic medication * lifetime schizophrenia or bipolar disorder * suicidality or homicidality * unlikely to be able to complete 1 year follow up * unable to speak or read english at a third grade level

Keywords: disulfiram cognitive behavioral therapy contingency management drug abuse therapy educational/resource design/development
clinical trial on binge eating disorder, treatment with naloxone spray

Conditions: Binge Eating Disorder

Summary: the investigators are studying a new treatment for one subtype of obesity. obesity is not a disease. it is a symptom of several different diseases. these diseases have distinct etiologies, being caused by aberrations in different mechanisms. forms of obesity caused by such non-critical mechanisms might be corrected fairly easily and safely. the investigators are interested in overeating and obesity that is caused by the opioidergic system. the opioidergic system appears to be responsible for a subtype of obesity associated with binge eating disorder (bed). people, especially with the right genetic predisposition, can become addicted to foods that release endorphins, in the way that people become addicted to exogenous opiates and other drugs that release endorphins. the particular application in our proposed clinical trial is for intranasal (in) naloxone. the peak levels of naloxone were similar and the bioavailability of naloxone intranasally was 100% (the same) of that available iv." in administration of naloxone has since been broadly tested in humans, as well, where it has been shown to be safe, with pharmacokinetics similar to those of naloxone given by injection .


Eligibility criteria:
inclusion criteria: * binge eating disorder (dsm-iv) and body mass index (bmi) \> 25 * binge eating screen \> 20 exclusion criteria: * pregnancy * drug usage * retarded * severe mental illness
assessing the ability of the t-spot®.tb test (iq)

Conditions: Tuberculosis

Summary: the primary objective of this clinical research study is to demonstrate performance of the normalized tb specific lymphocyte response (ntbslr) in identifying patients with active tb disease. the secondary exploratory objective is to demonstrate that active tb cannot be identified using an antigen-to-mitogen ratio derived from an elisa-based igra.

this study will enroll up to 202 subjects (assumes 15 % exclusion/drop-out rate). the target number of subjects is 75 active tb (recruited from subjects presenting at tb clinics) and 100 active tb excluded (recruited from subjects in the community). all subjects enrolled in this study will be men or women, aged 18 years or older. duration: 1 year

Eligibility criteria:
subject inclusion criteria: cohort 1a and 1b * must be at least 18 years of age * must be able to provide informed consent * must be able to provide a minimum of 10 ml of whole blood at each visit * must be t-spot.tb positive * first visit suspect tb subjects with no prior history of tb diagnosis subject exclusion criteria: cohort 1a and 1b * negative in the t-spot.tb test * previous or pre-existing confirmed tb diagnosis * on anti-tb treatment for less than 1 week\* * not meeting inclusion criteria subject inclusion criteria: cohort 2a and 2b * must be at least 18 years of age * must be able to provide informed consent * must be able to provide a minimum of 10 ml of whole blood at each visit * must be t-spot.tb positive * no prior history of tb diagnosis subject exclusion criteria: cohort 2a and 2b * negative t-spot.tb test * previous or pre-existing confirmed tb diagnosis * on anti-tb treatment * symptoms of active tb * not meeting inclusion criteria

Keywords: tb
muscular training-induced changes in copd

Conditions: Chronic Obstructive Pulmonary Disease; Healthy

Summary: the current protocol is developed in the context of a large research and innovation (r\&i) program aiming the promotion of daily life physical activity in chronic patients registered at clinicaltrials.gov (nct02976064) and approved by the ethical committee of the hospital clinic de barcelona (hcb/2016/0883). the project is partly supported by the smart innovation strategies promoted by the eu commission (comrdi15-1-0016). specifically, the protocol uses retrospective information collected between 2005-2008 as part of the eu project biobridge (lshg-ct-2006-037939). the aims of the current analysis of the retrospective information are 1) to assess training-induced changes in muscle oxygen saturation (sto2) assessed by near-infrared spectroscopy (nirs) during constant-work rate cycling exercise (cwre) as a useful marker of the effects of training at limb muscle level in patients with chronic obstructive pulmonary disease (copd), and 2) to further explore underlying mechanisms of skeletal muscle dysfunction as a characteristic systemic effect of copd, potentially modifiable with preventive interventions as endurance muscle training. methods: incremental exercise (vo2 peak) and cwre at 70% baseline peak work rate, before and after 8-week of endurance exercise training, were done in healthy sedentary subjects and copd patients. nirs was used to assess sto2 in the left "vastus internus" during the cwre (before an after training program) (objective 1); and blood samples and muscle biopsies of the quadriceps were obtained at rest (before an after training program) (objective 2).


Eligibility criteria:
inclusion criteria: * copd diagnosis following gold criteria (fev1/fvc post-broncodilator \<0,7) * clinical stability for at least 3 months exclusion criteria: * age \<45 years * any active cancer * comorbidities which carry high-level of handicap * other respiratory disease than copd * no sign of informed consent

Keywords: exercise training muscle dysfunction copd
eating disorders among adolescents

Conditions: Eating Disorders

Summary: the aim of the present study is to evaluate the prevalence of eating disorder among adolescents. also, to evaluate psychiatric comorbidity, sleep problems, alexithymia and emotion dysregulation associated with patients had eating disorders. in addition, to identify possible risk factors associated with eating disorder among adolescents.


Eligibility criteria:
inclusion criteria: * age between 10 to 18 years old. * males and females are included. exclusion criteria: * - participants were previously diagnosed with any psychiatric disorder.