Kornimate/medical-research-clean huggingface dataset:
penthrox™ in the canadian emergency department (ed)

Conditions: Pain, Acute

Summary: this canadian, multi-centre, prospective, real world study is designed to evaluate the effectiveness of low dose methoxyflurane (meof) (penthrox™) for the treatment of moderate to severe pain associated with trauma in the canadian ed.

the study will assess the change in pain intensity over 20 minutes from start of administration of penthrox™ and will generate real world evidence in support of existing clinical trial data including effectiveness, safety and additional parameters of low dose meof (penthrox™) in canadian eds.

Eligibility criteria:
inclusion criteria: 1. conscious adult patients: ≥ 18 years of age 2. moderate to severe pain associated with trauma (nrs0-10 ≥ 4) which is unlikely to require surgery/hospitalization, such as * musculoskeletal injuries and physical wounds * fractures * lacerations * burns * dislocations * contusions * injury due to foreign bodies 3. patient (and/or patient's authorized legal representative) should understand the nature of the study and provide written informed consent 4. patient is able to follow all study requirements and procedures and complete required questionnaires exclusion criteria: 1. multi-level trauma 2. women of child bearing potential who are pregnant or peri partum, including labour 3. an altered level of consciousness, due to any cause, including head injury, drugs, or alcohol 4. clinically significant renal impairment 5. a history of liver dysfunction after previous meof use or other halogenated anesthetics 6. hypersensitivity to meof or other halogenated anesthetics, or to butylated hydroxytoluene 7. known or genetically susceptible to malignant hyperthermia or a history of severe adverse reactions in either patient or relatives 8. exacerbation of an underlying condition (i.e., chronic pain) 9. clinically evident or potential hemodynamic instability as per the opinion of the investigator 10. clinically evident respiratory impairment as per the opinion of the investigator 11. prior treatment with penthrox within 3 months
project bloom regulatory clinical evaluation - system accuracy, user performance and system use evaluation

Conditions: Diabetes Mellitus

Summary: clinical evaluation including system accuracy, user performance, system use, instructions for use and marketing claims evaluation.


Eligibility criteria:
summary of inclusion criteria: * able to voluntarily provide written informed consent to participate in the study. * user performance accuracy testing only: self-monitoring - subject is currently performing unassisted self-monitoring of blood glucose. * for subjects participating in the in vivo glucose adjustment procedure age range is 18 - 45. summary of exclusion criteria: * female subjects who are pregnant or lactating. * subjects who, in the opinion of the investigator, are unsuitable for participation in the study. * user performance accuracy testing only -prior involvement with the investigational bgms being used in this study.
integration of hypertension management into hiv care in nigeria

Conditions: Human Immunodeficiency Virus; Hypertension

Summary: this study evaluates a tailored-practice facilitation (pf) strategy for integrating a task strengthening strategy for hypertension control (tassh) for the care of patients living with hiv (pwh) within primary health centers (phcs) in lagos, nigeria.

although access to antiretroviral therapy has led to increased survival among people living with hiv (pwh) in africa, this population now has higher cardiovascular disease (cvd) - mortality than the general population largely due to an increased burden of hypertension. in nigeria, the acute shortage of physicians limits the capacity to control hypertension among pwh at the primary care level where the majority receive treatment. this study proposes the use of practice facilitation (pf) - which will provide external expertise on practice redesign and a tailored approach to delivery of the evidence-based task strengthening strategy - to integrate hypertension into the hiv care model. using a clinical-effectiveness implementation design, we will evaluate the effect of a pf strategy for integrating an evidence-based intervention for hypertension (htn) control into hiv care among 960 patients with uncontrolled htn in 30 primary health centers (phcs) in nigeria. study is in 3 phases: 1) a pre-implementation phase that will develop a tailored pf intervention for integrating tassh into hiv clinics; 2) an implementation phase that will compare the clinical effectiveness of pf vs. a self-directed condition (receipt of information on tassh without pf) on bp reduction; and 3) a post- implementation phase to evaluate the effect of pf vs. self-directed condition on the adoption and sustainability of tassh. the pf intervention comprises: (a) an advisory board to provide leadership support for implementing tassh in hiv clinics; (b) training of the hiv nurses on tassh protocol; and (c) training of practice facilitators, who will serve as coaches, provide support, and performance feedback to the hiv nurses

Eligibility criteria:
inclusion criteria: * be an adult aged 18 years and older. * attends one of the 30 hiv clinics. * have a diagnosis of htn with uncontrolled blood pressure, i.e. bp is 140-179/90-100 mm hg. * ability to provide consent. exclusion criteria: * bp\>180/110 mm hg; * history of chronic kidney disease, heart disease, diabetes or stroke, pregnancy * inability to provide informed consent. * refusal to participate in the study.

Keywords: hypertension implementation science research integrated models practice facilitation people living with hiv human immunodeficiency virus cluster trial
effect of brimonidine on corneal thickness

Conditions: Impact of Brimonidine on the Cornea

Summary: brimonidine, an alpha-2 adrenoceptor agonist, is an effective and safe medication which is widely used in glaucoma treatment. although it is known that it is quickly taken up by the cornea following topical administration and that the cornea has alpha-2 adrenoceptors there are only few studies available on the impact brimonidine has on the cornea. the aim of the study is to find out 1. whether topical administration of brimonidine results in interaction with corneal alpha-2 adrenoceptors in terms of an increase in corneal thickness and 2. whether there are any differences between the response corneal epithelium, stroma and endothelium show to alpha-2 adrenoceptor stimulation.


Eligibility criteria:
inclusion criteria: * healthy, 18-99 years, normal ophthalmologic history, consent to participate in the study exclusion criteria: * any serious medical or neurologic conditions and/or regular use of local or systemic medications

Keywords: brimonidine alpha-2 adrenoceptor cornea corneal thickness
development of a videogame prototype targeting cigarette and marijuana smoking, and tobacco product prevention among young adolescents

Conditions: Smoking

Summary: to study feasibility and implementation of a education videogame and the effects on adolescents knowledge and beliefs around tobacco products.

the goal for sub-study 4 is to learn more about how an educational videogame can feasibly be implemented and disseminated in youth programs. for this sub-study we will further develop, expand, and refine the smokescreen game and increase the game's reach on a national platform. the study will conduct the proposed evaluation by: working with game developers to develop a web- based version of the game, creating a pre-post survey to measure the effect of the game and building that into the smokescreen game to anonymously collect information on players' knowledge and beliefs around tobacco products, and collaborating with youth programs to pilot test how the game can be implemented in real world settings.

Eligibility criteria:
inclusion criteria: * must be able and willing to sit at a computer or mobile device for 45-60 minutes per session to play the game and answer questions before and after playing video game. * be enrolled in a youth program that we have a partnership with exclusion criteria: * up to the discretion of the study team
surgery impact on circulating tumor dna in pancreatic cancer

Conditions: Resectable Pancreatic Cancer

Summary: pancreatic cancer represents the fourth cause of death by cancer in western countries. the only curative treatment is surgery but this one is possible only in 10 to 15 % of cases. to date, there are few biomarkers in circulating blood as prognostic or diagnostic markers in pancreatic cancer. the purpose of this study is to determine if the pancreatic tumor mobilization during its resection impacts the quantity of circulating tumor dna in peripheral and portal blood.

the investigators will analyze if the tumor mobilization increases circulating dna rate in peripheral and portal blood. moreover, circulating tumor dna will be measured during 12 months after surgery in peripheral blood. they will use a gene mutation detection technique called next generation sequencing (ngs) which is more specific than a simple polymerase chain reaction (pcr).

Eligibility criteria:
inclusion criteria: * every patient taken care by toulouse university hospital for the resection of a non-metastatic pancreatic adenocarcinoma by whipple resection. * patient aged over 18 years old * patient having given his written consent * patient with social insurance coverage exclusion criteria: * patients who had surgery, but their pathological examination of the resected specimen does not contain adenocarcinoma. * patient for whom the surgery was not realized (exploratory laparotomy)

Keywords: circulating tumor dna kinetic pancreatic cancer pancreatoduodenectomy next generation sequencing
effectiveness of a mayan language social media campaign on covid-19 vaccine beliefs in guatemala

Conditions: Vaccination Refusal

Summary: prior evidence, including formative work supporting the development of this study, suggests there is widespread vaccine hesitancy among indigenous communities in guatemala, fueled by mistrust in the health system, lack of official information, and the circulation of myths and misinformation. we will test the effectiveness of a video-based social media campaign that provides a basic overview of the science behind covid-19 vaccines and addresses prevalent myths and misinformation being shared in target communities. a series of animated videos will be promoted through facebook ads and randomized at the individual level across facebook users throughout the entire country. to investigate the effectiveness of mayan language content, we are testing three treatment arms - visually identical videos in the 1) spanish language, 2) k'iche' language, and 3) kaqchikel language. our primary outcomes are responses to two attitudinal questions collected via facebook polling: 1) how safe do you think a covid-19 vaccine is for people like you? (options: very safe, somewhat safe, barely safe, not safe, don't know); and 2) when you think of most people whose opinion you value, how much would they approve of people getting a covid-19 vaccine? (options: definitely approve, mostly approve, somewhat approve, not at all approve, don't know). we will measure effects of the three treatment arms across spanish speakers (including k'iche' and kaqchikel speakers who also speak spanish). we will also measure the effectiveness of k'iche vs. spanish content among k'iche speakers and kaqchikel vs. spanish content for kaqchikel speakers.


Eligibility criteria:
inclusion criteria: * the intervention will be delivered through the facebook ads platform. intervention content will be promoted to facebook users throughout the entire country of guatemala. k'iche' content will be targeted only in departments where the k'iche' language is primarily spoken. kaqchikel content will be targeted only in departments where the kaqchikel language is primarily spoken. exclusion criteria: * only adult facebook users of age 18 will be included. users under age 18 are excluded.
analgesic efficacy of local anesthetic transversus abdominis plane (tap) blocks in abdominal surgery

Conditions: Pain

Summary: the aim of the study is to establish the efficacy of local anaesthetic tap (transversus abdominis plane) blocks in providing pain relief in the first 24hrs following open or laparoscopic elective abdominal colorectal operations. tap blocks involve the injection of local aesthetic (ropivicaine) into the transversus abdominis plane in the abdominal wall. this injection takes place after induction of anaesthesia, but before the commencement of surgery. tap blocks have been proposed as a potential safer alternative to epidural anaesthesia. the blocks have been extensively used in the hunter new england system over the last 18 months. as yet there is no clear evidence for there efficacy, hence the need for this trial. this trial would establish the efficacy of this practice. if the technique proves effective it could be widely used and provide a simpler method of managing post operative pain.


Eligibility criteria:
inclusion criteria: * all patients aged 18 and over undergoing elective open or laparoscopic colorectal surgery performed by the participating surgeons within the study period will be considered for the trial. exclusion criteria: * history of adverse reaction to ropivicaine or similar drug. * inability or refusal to give consent * coagulopathic * severe renal impairment * aged \<18 years

Keywords: postoperative analgesia abdominal surgery ropivacaine local anaesthesia tap block pain management
the effect of eating disorder on occupational balance in university students

Conditions: University Student; Eating Disorders; Occupational Balance

Summary: the aim of this study is to examine the effect of eating disorders on occupational balance in university students. occupational balance levels will be compared in university students with and without eating disorders. the study will be finalized with the voluntary participation of 105 university students for both groups and 210 university students in total. the relationship between eating disorder tendencies and occupational balance in university students will be examined.

the population of the study will consist of voluntary students between the ages of 18-25 who continue their university education. in the power analysis performed to determine the sample size, it was determined in the g\*power program, with 95% power (alpha = .05, two-way), the effect size was taken as cohen's d = 0.5 by the guidelines provided by j. cohen, and it was determined that at least 105 people in each group and 210 people in total were needed for the independent sample t-test. inclusion criteria: * volunteering to participate in the study, * to be able to read and write turkish, * to be between the ages of 18-25 and studying at undergraduate level exclusion criteria: * any disability, * presence of a chronic disease individuals who volunteered to participate in the study will be evaluated with data collection forms filled in through questionnaires. demographic information about the individuals (such as class, department, age, and gender) will be obtained with the sociodemographic information form. data collection tools will be used by the researchers in face-to-face interviews with the participants and the data will be recorded anonymously. it will be determined whether the participants have an eating disorder according to the results of the scoff eating disorders scale. participants with eating disorders will constitute the research group and participants without eating disorders will constitute the control group. both groups will complete the occupational balance questionnaire and their occupational balances will be compared. the study was planned to be terminated when there were at least 105 participants in each of the research and control groups for the endpoint.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the study, * to be able to read and write turkish, * to be between the ages of 18-25 and studying at undergraduate level. exclusion criteria: * having any disability, * presence of a chronic disease.
torque teno virus: a biomarker of immunosuppression

Conditions: Renal Transplant Rejection; Immunosuppression; Renal Transplant Failure; Renal Transplant Infection

Summary: to seek an association between torque teno virus dna titres resulting from under or over-immunosuppression in a kidney allograft recipient, graft rejection, both cell-mediated rejection and antibody-mediated rejection, donor-specific antibodies (dsa), the incidence of bk viraemia and bk nephropathy, cmv infection or diseases and pcp infection and the number of circulating nk, b and t lymphocyte subtypes.

balancing the adverse effects of over-immunosuppression such as infection and malignancy, to the risk of rejection, remains the central challenge for day-to-day clinical practice in transplantation. a quantitative measure of immunocompetence remains elusive, and in the absence of such markers, immunosuppression drug concentrations and clinical events, such as organ rejection, infection, malignancy etc. are used as surrogate markers of immunocompetence to guide therapy. as demonstrated in several studies, the torque teno virus is widespread amongst the general population. in theory, if one suppresses the immune system, these viruses should multiply, resulting in a higher dna level which can be detected by a simple blood test. hence, the dna level could be used as an indicator for the level of immunosuppression, along with the available blood tests to measure the level of toxicity of the said drugs. in this research to be done at the royal london hospital, the investigators aim to elucidate that the torque teno virus is widely prevalent in an ethnically diverse east london kidney transplant recipient population by conducting the viral pcr on blood samples already collected during their routine clinic visits. the population will include all kidney transplant recipients in a two-year period. the investigators will measure the correlation between the ttv dna level and drug concentrations of the immunosuppressive medications which will elucidate how the dna levels are affected by different drug concentrations. the investigators will then measure the correlation between the ttv dna levels, and the common adverse outcomes experienced by the transplant recipients, namely, patient death, loss of transplant organs, transplant rejection, rates of infection, and cancers in transplant patients by collecting data from patient records. these tests will help understand whether the torque teno virus dna levels can be used as a marker of immunosuppression in the general population in the uk.

Eligibility criteria:
inclusion criteria: * all consenting renal transplant recipients in the study period will be included in the study exclusion criteria: * no exclusion criteria.

Keywords: renal transplant immunosuppression torque teno virus
effects of transcutaneous spinal direct current stimulation on mobility in cases with multiple sclerosis

Conditions: Multiple Sclerosis; Transcranial Direct Current Stimulation

Summary: the primer aim of the study is to examine the effects of the transcutaneous spinal direct current stimulation (ts-dcs) on mobility in addition to the physiotherapy program to individuals with multiple sclerosis. our secondary aim is to show the relationship of these effects with ts-dcs through fatigue and quality of life evaluations.

our study is carried out at istanbul cadde medical center. the patients who will participate in the study are determined according to the inclusion criteria among the patients who applied to the multiple sclerosis polyclinic of istanbul medeniyet university göztepe training and research hospital, department of neurology. transcutaneous spinal direct current will be applied to the individuals participating in our study in 20-minute sessions, 3 days a week for 2 weeks. according to the type of stimulation applied, participants are divided into two groups: experimental and control groups by simple randomization. while cathodal ts-dau was applied to the patients in the experimental group; sham ts-dau is applied to patients in the control group. the same evaluations will be applied to all participants throughout the study, and the evaluations are applied before and after the intervention. the data collected as a result of the evaluations will be analyzed with spss version 22.

Eligibility criteria:
inclusion criteria: * patients diagnosed with ms and suffering from walking difficulties due to ms * edss score between 2-6 * being over 18 years old exclusion criteria: * relapsed within the last two months * changed medication within 45 days * hospitalized in the last three months * had other neurological or musculoskeletal problems * had an obstacle to stimulation (skin problems, metal implants, etc.) * do not want to participate in the study individuals
a study of the efficacy and safety of upadacitinib (abt-494) in participants with moderately to severely active crohn's disease who have inadequately responded to or are intolerant to biologic therapy

Conditions: Crohn's Disease

Summary: the objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in participants with moderately and severely active crohn's disease (cd).


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cd for at least 3 months prior to baseline. * confirmed diagnosis of moderate to severe cd as assessed by stool frequency (sf), abdominal pain (ap) score. * evidence of mucosal inflammation based on the simplified endoscopic score for crohn's disease (ses-cd) on an endoscopy confirmed by a central reader. * demonstrated an inadequate response or intolerance to any biologic therapy for infliximab, adalimumab, certolizumab pegol, vedolizumab, and ustekinumab. * if female, participant must meet the contraception recommendations. exclusion criteria: * participant with a current diagnosis of ulcerative colitis or indeterminate colitis. * participant not on stable doses of cd related antibiotics, oral aminosalicylates, corticosteroids or methotrexate (mtx). * participant with the following ongoing known complications of cd: abscess (abdominal or peri-anal), symptomatic bowel strictures, fulminant colitis, toxic megacolon, or any other manifestation that might require surgery while enrolled in the study. * participant with ostomy or ileoanal pouch. * participant diagnosed with conditions that could interfere with drug absorption including but not limited to short gut or short bowel syndrome. * screening laboratory and other protocol pre-specified analyses show abnormal results.

Keywords: upadacitinib crohn's disease efficacy safety
concurrent low intensity shockwave therapy on collagenase clostridium histolyticum for peyronie's disease

Conditions: Peyronie Disease; Erectile Dysfunction

Summary: the purpose of this research is to determine whether or not low-intensity shockwave therapy (liswt) with xiaflex treatment will result in greater improvements to the curvature of the penis.


Eligibility criteria:
inclusion criteria • diagnosed with pd * palpable penile plaque * dorsal, lateral, or dorsolateral penile curvature * penile curvature \> 30 degrees and \< 90 degrees as measured using goniometer during objective curvature assessment * non-calcified plaque or grade 1 calcification ("stippling", no shadowing) as determined by penile duplex doppler ultrasound (pddu) * "stable pd symptoms' defined as pd symptom duration \> 6-months or stable symptoms \> 3-months exclusion criteria: * prior intralesional injections or surgery for pd. * severe baseline penile pain. * moderate or severe baseline ed based on iief-ef domain. * history of low intensity shockwave therapy for sexual dysfunction (ed or pd). * ventral (downward) or ventrolateral penile curvature. * moderate or severe (grade 2/3) plaque calcification as determined by pddu. * inability to achieve satisfactory erection rigidity at time of baseline curvature assessment.