Kornimate/medical-research-clean huggingface dataset:
identification of sentinel lymph nodes with methylene blue and isotope

Conditions: Infiltrative Breast Cancer

Summary: the aim of this study is to evaluate the performance of a double labelling method using isotope and methylene blue dye injection to localize precisely sentinel lymph node (sln) in a series of 100 patients with infiltrative breast cancer justifying sln excision. method and patients: sln excision will be performed on 100 patients treated for infiltrative breast cancer. after preoperative methylene blue dye injection and lymphoscintigraphy, individual localization of the radioactive and stained nodes will be performed. after the surgery, sln will be submitted to serial analysis and immunohistochemistry. a comparison of the two methods and an economical evaluation of the complete procedure will be performed.


Eligibility criteria:
inclusion criteria: * patients with infiltrative breast cancer (diagnosed pre-operatively by core biopsy) * approval and informed consent exclusion criteria: * chemotherapy * locoregional radiotherapy * prevalent axillary lymph node

Keywords: sentinel lymph node sln probe breast cancer lymphoscintigraphy methylene blue dye
use of optune ttf with radiation as an alternative for elderly patients with primary cns lymphoma

Conditions: Central Nervous System Neoplasms, Primary

Summary: this study will compare the overall survival (os) time of elderly patients who would not tolerate standard chemotherapy for pcnsl treated with wbxrt together with optune-ttf to those treated with whole-brain radiotherapy alone. standard treatment of primary central nervous system lymphoma (pcnsl) for patients with good performance status involves high-dose methotrexate-based chemotherapy regimens and whole-brain radiation therapy (wbxrt). although up to 20% of patients with pcnsl are 80 years of age or older, little data exist with regard to optimal treatment of this patient population and they often do not qualify for clinical trials. in addition, elderly patients have a poorer rate of complete and partial response and increased risk of toxicity when treated with standard chemotherapy regimens. though a consensus does not exist, radiotherapy alone is often used in these patients to minimize toxic effects of more aggressive chemotherapies. the optune ttf device has proven effective in treating high-grade gliomas and is currently being investigated to treat meningiomas and metastatic lesions in the brain as well as other tumor types elsewhere in the body. it is generally well tolerated with no known systemic side effects, producing only an occasional local skin reaction. the mechanism of action is independent of tumor type and therefore may be effective in treating lymphoma as well.


Eligibility criteria:
inclusion criteria: * histological de novo diagnosis of pcnsl * tumor located in the supra-tentorial brain region * karnofsky performance score of 70 or above * ineligible for chemotherapy due to age or other co-morbidities * life expectancy of at least 3 months * patient has a caretaker willing to assist with study compliance * patient is able to provide written consent on their own behalf exclusion criteria: * second or subsequent recurrence of pcnsl * patient wishes to receive systemic treatment * implanted electronic medical device in the brain (deep brain stimulator, vagus nerve stimulator, programmable shunt, etc.) * skull defect without replacement * prior radiation, surgery, or chemotherapy for pcnsl within the 4 weeks prior to enrollment * patient unable to comply with optune device treatment or the study follow- up schedule * active participation in another therapeutic clinical trial * patient unable to provide written consent on their own behalf

Keywords: pcnsl, primary central nervous system lymphoma
covid-19 lockdown and deviant sexual fantasies

Conditions: Deviant Sexual Fantasies

Summary: our society is going through an unprecedented situation: the covid 19 pandemic is forcing many populations, worldwide, into confinement for their own protection. the very characteristics of this confinement and of the disease (isolation, potential severity of the illness, being psychologically unprepared for such a circumstance) have a significant impact on one's psyche, like emotional disorders -anxiety/depression-, difficulties when returning to normal life, vicarious traumas... confinement is paradoxical in as although well-intended to protect the individual, it leads to the isolation of the individual. this paradox is destabilizing one's feelings, because when the investigators feel the need for protection and reassurance, the investigators are left alone and feel abandoned. the investigators therefore understand that this confinement framework is in essence a situation that might revive unresolved deprivation situations from the childhood. how to react in front of this upsurge in anxiety? strategies used may include, among others, escape in the imaginary through numerical tools or others, and /or going to the actual characterized by deviant sexual behaviours. the investigators know in fact that certain moments, like anxiety, depression, boredom, psychological unrest are propicious for acting, for violent sexual offenders. the investigators therefore pay extra attention to our patients in such periods favoring these kinds of trouble. this study will enable us to understand if the confinement associated with covid 19 has generated anxiety that lead sexual offenders or individuals with paraphilic disorders to engage into deviant fantasies or, potentially sexual activities.

the questionnaire is handed only one time to each patient and the questions it contains are part of those commonly used. how do the investigators precisely operate: self questionnaire on paper, handed to each patient followed by the criavs in the waiting room, and returned by the patient to the therapist, or the department, in a sealed envelope. digital data collection thereafter.

Eligibility criteria:
inclusion criteria: * adults * consulting at the criavs between june and end october 2020 exclusion criteria: * no demance * no decompensated psychatric disorder * no tutelage

Keywords: sexuality confinement sex offender outcome paraphilia cybersexuality
a phase iia study of bms-512148 to assess safety, exposure, and biological effects in stable type 2 diabetic subjects

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this clinical research study is to assess the safety of, exposure to, and biological effects of bms-512148 in stable type 2 diabetic subjects


Eligibility criteria:
inclusion criteria: * established diagnosis of type 2 diabetes mellitus, who are treated with metformin or diet alone (drug naive). * fasting glucose (fg) \< - 240 mg/dl, while on metformin or antidiabetic diet alone. * hba1c (hemoglobin a1c) in the range of 6.0-10.0% exclusion criteria: * women of childbearing potential
rebound pain following surgery with regional anesthesia block

Conditions: Regional Anesthesia Morbidity; Pain, Postoperative

Summary: for some kinds of surgery, anesthesiologists provide nerve blocks (regional anesthesia) to reduce pain from surgery by injecting freezing medication around deep nerves with ultrasound. nerve blocks help with pain control following surgery and reduce the amount of strong opioids needed but relatively little research has focused on the pain that occurs once the nerve block has worn off. this is called rebound or transition pain. this research study will prospectively collect data including pain scores before, during and after nerve blocks are given for surgery. we will look at the type of nerve blocks and other analgesia medications used with the aim of quantifying rebound pain to better understand how to limit it's impact on quality postoperative pain control.


Eligibility criteria:
inclusion criteria: * age 18-75 years * receiving peripheral nerve block as part for anesthesia/analgesia as part of standard perioperative care for surgery performed at university of alberta hospital during a 6 month period * elective and emergency surgery exclusion criteria: * inability to consent to participate in the study (illiteracy, \<7th grade education) * contraindication/history of hypersensitivity to local anesthetics

Keywords: rebound pain nerve block
drug-induced repolarization ecg changes

Conditions: Long QT Syndrome; ADHD; Depression; Death; Death, Sudden, Cardiac; Romano-Ward Syndrome; Pathologic Processes; Heart Arrest; Electrocardiogram: Electrical Alternans; Heart Diseases; Cardiovascular Diseases; Death, Sudden; Arrhythmias, Cardiac; Heart Defects, Congenital; Cardiovascular Abnormalities; Congenital Abnormalities; Genetic Disease; Genetic Syndrome; Qt Interval, Variation in; Psychiatric Disorder

Summary: studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for attention-deficit hyperactivity disorder (adhd) and depression. the qt-interval on a electrocardiogram (ecg) is often used to assess the patients risk of developing heart arrhythmias. the qt-interval defines the hearts electrical resting period and a long interval is linked to an increased risk of developing heart arrhythmias. in this project the investigators wish to examine possible side-effects in patients receiving medication for adhd and depression and their dynamic qt-interval changes, by analysing the ecg changes that occur during "brisk standing".


Eligibility criteria:
inclusion criteria: * over 18 years old * patients treated with methylphenidate * patients treated with methylphenidate and qt-prolonging ssri * patients treated with methylphenidate and a non qt-prolonging ssri exclusion criteria: * patients considered in an unstable phase in their psychiatric condition * patients that are not able to understand the information regarding the trial, or who are unable to cooperate.
aquatic_training in obese women

Conditions: Obesity

Summary: this study aims to assess the effects of 10-week water-based aerobic training (thrice a week) on anthropometrics, biochemicals, cardiovascular parameters, and explosive strength in young overweight and obese women. the findings indicate that water-based aerobic training could be a useful program to enhance body composition, biochemical, cardiovascular, and explosive strength parameters in young overweight and obese women compared to inactive persons

this study is based on a randomized controlled trial with a pre-to-post testing design, twenty-seven young overweight and obese women were assigned to training group (a water-based aerobic training) or control group (maintaining their usual activities during the studying period. for each training session, water activities were implemented for 50 min which included warm-up (10 min), main activities (30 min), and cool-down (10 min). the swimming pool where the intervention took part was 1.50 m deep of water. the pre- and post-intervention participants were assessed for their anthropometrics, biochemicals (fasting glycemia, total cholesterol, high-density lipoprotein cholesterol (hdl-c), low-density lipoprotein cholesterol and triglyceride (tg)), resting blood pressure, and resting heart rate, and explosive strength of upper (countermovement jump and squat jump) and lower limbs (a seated medicine ball throw test).

Eligibility criteria:
inclusion criteria: * age between 20 and 35 years * sedentary lifestyle within six month * not using drugs or other therapy for obesity. exclusion criteria: * bmi below 25.0 and over 34.9 kg.m-2 * having any infectious or skin diseases

Keywords: aquatic training body composition lipid profile obesity management physical fitness testing resting heart rate
a randomized control trial: returning to run after injury

Conditions: Knee Injuries

Summary: the purpose of this study is to examine the effectiveness of telehealth via video feedback to transition rear foot strike runners to non-heel strike runner following a lower extremity injury. telehealth re-education gait training is much cheaper than in-clinic retraining sessions with a medical provider and could be much more widely used by both consumers and researchers as a training aid, a way to help alter running form, prevent running injuries and be used as a tool for use in the rehabilitation of running related injuries.

a convenience sample of 30 runners from the united states military academy (usma) at west point, new york (ny) who are recovering from a lower-extremity injury and are interested in participating in a return to run program. acceptable lower-extremity injuries can include stress fractures proximal to the ankle, anterior chronic exertional compartment syndrome (cecs), patella-femoral pain syndrome, osteoarthritis of the lower-extremity, iliotibial band syndrome, chronic lower-extremity pain and or any participant that may benefit from the following; shorter stride, increased step rate, reduced knee loading, and reduced ground reaction force average vertical loading rates (avlr). all participants will be screened via questionnaire and physical assessment for inclusion / exclusion from the study. upon enrollment runners will be randomized into two groups. regardless of group, all runners will have their running form and foot strike pattern analyzed using an instrumented treadmill and high-speed motion capture initially and at week 10. kinetic and kinematic data including avlr, impulse, foot strike pattern (fsp), contact time, step length, and step rate will be recorded at these time points. additionally, all runners will receive the same graduated return to run intervals and 4-week home exercise program. runners randomized to the intervention group will receive additional video tele-health instruction on how to transition to a non-rearfoot strike (nrfs) running pattern. runners in the intervention group will have additional tele-health follow-ups at weeks 1, 2, 4,6, 8, and 10 using a tele-conferencing program and the hudl technique application. at each tele-health video follow-up participants will be emailed a questionnaire assessing their progress and function. at month 6 a final data collection session to include video analysis will be performed.

Eligibility criteria:
inclusion criteria: 1. pain free walking 2 miles in 35 minutes 2. weight bearing dorsiflexion (wbdf) range of motion (rom) 80% symmetry 3. 20 unassisted single leg heel raises 4. recovering from a lower-extremity injury exclusion criteria: 1. history of previous stress fracture / fracture of the foot 2. participant who already uses a non-rearfoot strike running pattern 3. participant is pregnant
gapcare: the geriatric acute & post-acute care coordination program for fall prevention in the emergency department

Conditions: Falls (Accidents) in Old Age

Summary: gapcare (geriatric acute \& post-acute care coordination program for fall prevention) is an early stage investigation that enrolls older adults who present to the emergency department after a fall to determine the feasibility of an emergency department (ed)-based multidisciplinary intervention for preventing recurrent falls in older adults.

falls are the leading cause of fatal and non-fatal injury among older adults. eds frequently evaluate older adults after their falls, but the typical evaluation consists of an injury assessment alone. there is a critical need for an ed-based intervention that addresses reasons for the fall and provides on-the-spot assessment and guidance to prevent subsequent falls. failure to prevent subsequent falls will result in increased morbidity, mortality, healthcare utilization, loss of independence, and rising health care costs as the population of older adults increases. participants in gapcare will be older adults (≥65 years-old) who present to the ed for a fall. we will pursue the following specific aims to test and further refine the gapcare intervention: (1) examine the feasibility of recruitment and retention of eligible patients into the gapcare intervention, (2) determine the initial efficacy of the gapcare intervention in reducing subsequent falls and healthcare utilization at 6 months. our long-term goal is to prevent the early morbidity and mortality of older adults who present to the ed after a fall. the overall objective of this survey is to gather preliminary data on the feasibility of an ed based fall prevention project.

Eligibility criteria:
inclusion criteria: * community-dwelling adult (non-institutionalized) 65 years-old or older presenting to ed after a fall * able to communicate in english * fall not due to syncope or external force (i.e., struck by car or assault) * fall not due to serious illness (i.e. stroke, acute myocardial infarction) * will be discharged to home, assisted living, or rehabilitation at completion of ed visit (i.e., not admitted) * legally authorized representative present to give informed consent if patient has cognitive impairment on six item screener (score of less than four) exclusion criteria: * unable to give informed consent due to intoxication or altered mental status * presence of injuries that prevent mobilization (i.e., pelvic or lower extremity fractures)

Keywords: emergency department prevention transitions of care
preoperative supine time for adrenal venous sampling

Conditions: Primary Aldosteronism

Summary: this study aim to understand whether the length of preoperative supine time would affect the avs outcome.

primary aldosteronism (pa) is the most common form of secondary hypertension, accounting for 5% of hypertensive patients and 17-23% in patients with resistant hypertension. compared to the primary hypertension, pa is more prone to cause severe organ damage and even early death. adrenal venous sampling (avs) is an effective confirmatory test for subtyping unilateral and bilateral adrenal hyperplasia, helping doctors to make an accurate decision between surgery or medication. supine in bed before avs is recommended for a desirable result of avs according to guidelines. however, investigating study about the most optimal preoperative supine time before avs is lacking. this is a single-center prospective randomized controlled study. 120 patients diagnosed as pa and with willing for further avs examination will be included. participants will be randomly allocated to 15-min supine time group or 2-hours supine time group. the primary outcomes are the degrees of clinical and laboratory remission (blood pressure, type and dose of antihypertensive drugs, serum potassium, orthostatic arr). the secondary outcomes are the technical success rate and adverse event of avs (selective index≥2 is considered as successful surgery without corticotropin stimulate). discussion: primary aldosteronism is an intractable public health problem, and many techniques including avs have been developed to correctly identify this disease. this study will help to understand whether the length of preoperative supine time would affect the diagnostic efficacy of avs, and thus help to formulate a more reasonable avs procedure.

Eligibility criteria:
inclusion criteria: 1. patients are clinically diagnosed as primary aldosteronism with arr≥37 (pac showed as pg/ml, renin showed as μiu/ml) and passed through pa confirmatory tests (pac-post cct\>110pg/ml, pac-post ssit \>80pg/ml, or pac-post fst\>60pg/ml). pac: plasma aldosterone concentration; 2. patients with willing for avs; 3. age 18 or above, male or female, with legal capacity. exclusion criteria: 1. patients with suspected adrenocortical carcinoma or pheochromocytoma; 2. patients with high risk of adrenal surgery; 3. patients have been subtyping to glucocorticoid-suppressible hyperaldosteronism or familial hyperaldosteronism type iii; 4. patients were diagnosed as cushing syndrome or subclinical cushing syndrome; 5. patients were treated with glucocorticoids recently; 6. patients with whole body or venipuncture area infection; 7. patients with venous access thrombosis; 8. patients are allergic to iodine; 9. patients with x-ray contraindications; 10. patients with coagulation dysfunction; 11. patients are unable to cooperate and follow-up.

Keywords: adrenal venous sampling preoperative supine time primary aldosteronism resistant hypertension
efficiency of function-oriented taping application in low back pain patients

Conditions: Low Back Pain; Kinesiophobia

Summary: purpose of this study is to determine the efficiency of functional tape application to patients with acute or subacute low back pain. 40 patients with acute-subacute low back pain were divided into two groups: control and experimental group. to control group, mckenzie exercises, transcutaneous electrical nerve stimulation (tens), hot pack (hp) and pulsed ultrasound treatments were applied. to experimental group, functional taping were applied in addition of these treatments. range of motion (rom), visual analogue scale (vas), tampa scale of kinesiophobia (tsk) and the oswestry disability index (odi) were evaluated preand post-treatment and datas were analyzed with statistical methods. in analysis; p value was accepted p\<0,05 for t test and mann whitney u test process. in the measurements that compared the improvement of both groups, based on pre- and post-treatment evaluations; improvement in the experimental group was significantly higher in all of these parameters of rom, vas, tsk and odi than in the control group (p\<0,05). the use of functional rigid taping in patients with acute and subacute low back pain provided a statistically significant improvement in all measured values of patients and provide better results than the control group. however, there is a need for comparative new studies in order to measure the effectiveness of rigid taping in a more accurate way.


Eligibility criteria:
inclusion criteria: * being between the ages of 20 and 65 * being literate in turkish * having lower back pain for less than 3 months * informed consent form for taping application to have been signed exclusion criteria: * allergic reaction on the skin * hypertension, type 2 diabetes mellitus (dm) and presence of accompanying systemic disease other than hypercholesterolemia * not being able to communicate * using corsets and similar supports * having a body mass index \> 30 * use of antidepressant and myorelexan medication

Keywords: rigid taping functional taping
healthysteps: exercise for older adults with mobility limitation

Conditions: Mobility Limitation

Summary: this study will compare three different exercise programs in older adults who report difficulty walking and will determine if the programs improve walking.


Eligibility criteria:
inclusion criteria: * men and women who live in the lower mainland (greater vancouver) area of british columbia * aged 65 years or older * living independently in their own home * report mobility limitation, defined as any difficulty walking one-quarter mile (about 2-3 blocks) outside on level ground or climbing one flight of stairs (about 10 steps) without resting because of a health or physical problem exclusion criteria: * have a current medical condition for which exercise is contraindicated * have participated in an exercise intervention study in the past 6 months * do not have adequate cognitive function to provide informed consent and participate fully in the study * do not speak and understand english fluently

Keywords: energy cost of walking energy metabolism aged older adult exercise gait walking aerobic motor skill