Kornimate/medical-research-clean huggingface dataset:
neural mechanisms of attention lapses in adult adhd

Conditions: Attention Deficit Disorder; Hyperactivity Disorder

Summary: adhd is a common disorder, leading to a significant disability that often persists in adulthood. adhd is characterized by attentional disturbances that are difficult to asses with standard neuropsychological tests. attention tends to stall after a certain time of fatigue (i.e. an attention lapse). the aim of this study is to study the electroencephalographic (eeg) characteristics of these attention lapses in a sustained attention task, comparing adhd patients with healthy subjects.

the main goal is to assess with eeg the timing of the attentional demobilization that precedes a sustained attention lapse in patients with adhd. the secondary objectives are: 1 / to analyze impaired cognitive control mechanisms during lapses in patients with adhd; 2 / study the relationships between the deficits identified through eeg recording, clinical evaluations, and the subjective perception of daily difficulties; 3 / to measure the impact of the subjective attention state on the neuronal precursors of the attentional lapses; 4 / evaluate the relation between propensity to wandering mind and attentional lapses.

Eligibility criteria:
inclusion criteria: * diagnosis of adhd according to dsm-5 criteria by a psychiatrist with clinical experience with adhd * aged 18 to 60 * having signed an informed consent * able to understand the objectives and the risks related to the research for healthy controls * absence of psychiatric disorder or neurological disease * matched in sex, age (± 2 years) and level of study (± 2 years) to each adhd patient exclusion criteria: * treatment by methylphenidate or amphetamine in the 3 months preceding the study * treatment by a psychotropic drug other than antidepressant ssri: anti-depressant non-ssri, antipsychotic, mood stabilizer, benzodiazepine or hypnotic daily intake * neurological pathology or neurological sequelae * history of head trauma with loss of consciousness of more than 15 minutes * subject under the protection of justice * subject under guardianship, curatorship * subject in exclusion period (determined by previous or current study), * impossibility to give the subject enlightened information (subject in emergency situation, difficulties of comprehension of the subject (for example mental retardation, illiteracy, subject not including french ...)

Keywords: electroencephalography neurocognition attention deficit attention lapses
potential benefits of expanded hemodialysis in prevention of sarcopenia

Conditions: Chronic Kidney Disease Requiring Chronic Dialysis

Summary: the current study will investigate whether long term implementation of expanded hemodialysis (hdx) will effectively decrease serum levels of large uremic toxins and ameliorate progression of sarcopenia in patients with chronic kidney disease requiring hemodialysis.

this is an open-label, prospective, 1:1 randomized, parallel-group, study to evaluate the efficacy of expanded hemodialysis (hdx) compared to conventional hemodialysis in patients with chronic kidney disease in south korea for up to 12 months.

Eligibility criteria:
inclusion criteria: * on hd treatment over 6 months before study enrollment * aged over 18 years * able to give informed consent exclusion criteria: 1. hemiplegia or paraplegia state 2. planned renal transplant or conversion to peritoneal dialysis within study period 3. active chronic infection or inflammatory conditions including autoimmune disease, inflammatory arthritis and active malignancy 4. history of monoclonal gammopathy 5. life expectancy \<12 months 6. pregnancy or breast feeding 7. receiving immunosuppressant medication 8. inability to complete study assessments
cpg 7909 in patients wih stage iv renal cell cancer

Conditions: Carcinoma, Renal Cell

Summary: cpg 7909 given alone to patients with renal cell cancer after their nephrectomy. cpg 7909 is as a subcutaneous injection once per week for up to 24 weeks. up to 40 patients will be included in the study.


Eligibility criteria:
inclusion criteria: stage iv renal cell carcinoma with lung and/or soft tissue metastasis nephrectomy measurable disease by recist criteria exclusion criteria: cns, bone or liver metastasis tumors that are mainly papillary, chromophobe, medullary, collecting duct, or unclassified prior immunotherapy, including il-2 or ifn-alpha

Keywords: renal cell carcinoma, phase i, phase ii, immunotherapy
screening diagnosis of fall risk after stroke and initial intervention: a fnirs study

Conditions: Stroke

Summary: this is a functional near infrared spectroscopy (fnirs) study designed to screen for risk of falls after diagnosis of stroke and initial intervention.

this was an initial screening and preliminary intervention study. each subject underwent two models of simultaneous fnirs-eeg testing during the sit-to-stand process, the first without any intervention and the second based on biofeedback (emg feedback) during the sit-to-stand process. initial screening of fall risk in post-stroke patients was performed by comparing differences in brain activation and brain network connectivity between patients and healthy subjects. preliminary validation the effectiveness of the emg feedback-based sitting and standing training for post-stroke patients by comparing the differences of brain activation, brain network connectivity, and electromyographic changes during the sit-to-stand process in the two models.

Eligibility criteria:
inclusion criteria: stroke patients 1. diagnosis of stroke confirmed by neuroimaging (ct or mri) evaluation 2. 18-85 years old 3. able to complete the sit-to-stand transition 4. able to follow instructions to complete the trial 5. patients who signed an informed consent form. healthy subjects: 1. no abnormalities on cranial fmri examination 2. 18-85 years old 3. able to complete the sit-to-stand transition 4. able to follow instructions to complete the trial 5. not taking medications. 6. subjects who signed an informed consent form exclusion criteria: stroke patients: 1. inability to tolerate the test due to organic diseases 2. serious mental illness that prevents them from cooperating with or tolerating the trial 3. pregnant or lactating women 4. had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction. healthy subjects: 1. inability to tolerate the test due to organic diseases 2. serious mental illness that prevents them from cooperating with or tolerating the trial. 3. pregnant or lactating women 4. had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction
clinical impact of a multiplex rapid diagnostic pneumonia panel testing in critically-ill patients with severe hospital-acquired pneumonia, ventilator-associated pneumonia and community-acquired pneumonia with high risk of multidrug resistant pathogen

Conditions: Infectious Disease of Lung; Molecular Diagnosis; Pneumonia

Summary: the objective of the research is to ascertain the influence of a syndromic mutiplex pcr assay (filmarray) on the management of patients hospitalised in the icu for severe respiratory disease. the diagnostic process for pneumonia has become significantly more intricate over the past decade due to the interference of the biological, radiological, and clinical criteria of patients hospitalised in the intensive care unit with the conventional criteria for the diagnosis of severe respiratory diseases. additionally, patients who are hospitalised in the icu are at a heightened risk of contracting other associated infections. consequently, patients are frequently administered antibiotics, whether or not they are effective, as it is challenging to promptly determine the aetiology of their symptoms using conventional methods. to enhance the diagnostic and therapeutic aspects of their treatment, we implemented a novel syndromic molecular test in our laboratories. this test is designed to expedite and enhance the management of pneumonia and the stewardship of antibiotics. this research will include 80 to 100 adult patients hospitalized in icu between feb 2025 and feb 2027. it will take place within the siriraj hospital, bangkok, thailand.

not provided

Eligibility criteria:
inclusion criteria: * patients who have received complete information about the research and who have not objected to the use of its data * patients with suspected pneumonia infection exclusion criteria: patients with following conditions; * active immediate life-threatening cardiac arrhythmia, defined as ventricular tachycardia and ventricular fibrillation * acute cerebral vascular event, including both acute ischemic stroke or intracranial hemorrhage acute coronary syndrome * cardiogenic shock * life-threatening gastrointestinal hemorrhage * drug overdose * advanced-stage cancer with predicted survival less than 1 year
a phase 3 study comparing 2 doses of cp-690,550 vs. placebo for treatment of rheumatoid arthritis

Conditions: Arthritis, Rheumatoid

Summary: this phase 3 study is intended to provide evidence of the efficacy and safety of cp 690,550 when dosed 5 mg and 10 mg twice a day as monotherapy in adult patients with moderate to severe rheumatoid arthritis. it is intended to confirm the benefits of cp-690,550 in improving signs and symptoms and physical function that were observed in the phase 2 rheumatoid arthritis studies.


Eligibility criteria:
inclusion criteria: * the patient has a diagnosis of ra based upon the american college of rheumatology (acr) 1987 revised criteria. * the patient has active disease at both screening and baseline, as defined by both: ≥6 joints tender or painful on motion; and ≥6 joints swollen; and fulfills 1 of the following 2 criteria at screening: 1.esr (westergren method) \>28 mm in the local laboratory. 2. crp \>7 mg/l in the central laboratory * patient had an inadequate response to at least one dmard (traditional or biologic) due to lack of efficacy or toxicity. * no evidence of active or latent or inadequately treated infection with mycobacterium tuberculosis. * patient has washed out of all dmards other that antimalarials exclusion criteria: * blood dyscrasias including confirmed: 1. hemoglobin \<9 g/dl or hematocrit \<30%; 2. white blood cell count \<3.0 x 109/l; 3. absolute neutrophil count \<1.2 x 109/l; 4. platelet count \<100 x 109/l * history of any other autoimmune rheumatic disease other than sjogren's syndrome * no malignancy or history of malignancy. * history of infection requiring hospitalization, parenteral antimicrobial therapy, or as otherwise judged clinically significant by the investigator, within the 6 months prior to the first dose of study drug

Keywords: antirheumatic agents clinical trial
acute admission to hallingdal sjukestugu

Conditions: Morbidity; Health Economy; Quality

Summary: the main objective of the project is to assess whether a community hospital may have or should have a role in the norwegian health care system in the acute treatment of a defined group of patients.

the research project's objective is to analyze whether acute admissions to hallingdal sjukestugu (hss) is a real alternative to hospitalization in a general hospital. hss is a community hospital and a department under ringerike general hospital (rs) and is located in hallingdal 170 km from the rs. it is an established practice that the general practitioners in hallingdal send selected patients in need for acute treatment to hss in place of rs. in 2008 this accounted for 10.1% of the total number of acute inpatients from the six municipalities of hallingdal. the research program includes a prospective, randomized study in which all patients intended for acute inpatient at hss are distributed randomly into two groups, an intervention group who is admitted to hss, and a control group who is sent to rs. a minimum of 70 patients are included in each group. the patients are going to be followed through one year after the hospital stay and all contacts with the specialist health services and the municipal health care services will be registered. there will also be collected data on the patients' functioning level and the patients' opinion about quality of the hospital stay. through standardized questionnaire the involved health professional will be asked about their reviews. three studies will analyze the patients' progress, economics and quality in the two groups. the three studies will together constitute a doctoral thesis. the research project will provide a better basis for assessing the role of local medical centers in the norwegian health care in the acute treatment of a defined group of patients.

Eligibility criteria:
inclusion criteria: * patients who by the general practitioner are intended for acute admission to hss and where the specialist on call at rs approves such admissions. * patients residing in hallingdal municipalities. exclusion criteria: * patients with injuries and acute and/or unclear illnesses in need of diagnosis, treatment or monitoring in an acute hospital. * urgent births at hss. * acute psychiatric admissions to hospital. * patients with serious mental disorders. * patients who during the follow-up year move to a municipality outside of hallingdal.

Keywords: community hospital alternative acute admissions
alkagin paste in the prevention of radiation dermatitis

Conditions: Anus Neoplasms; Rectal Neoplasms; Urogenital Neoplasms

Summary: the purpose of this study is to determine whether alkagin paste is effective at preventing radiodermatitis in patients receiving external beam radiation therapy to the perineal area.


Eligibility criteria:
inclusion criteria: * patients receiving a dose of 45 gy or more with concomitant chemotherapy to the perineal skin (for treatment of anal canal, low rectal or gynecological cancer). * patients able to understand and sign an informed consent form. * patients that do not have active connective tissue disorders. * patients 18 years or older. * patients that did not receive any previous radiation. * patients that do not have any known allergy to any ingredients of the alkagin paste * patients need to be able to apply the creams themselves or have help with applying the creams. * patients who have been offered to purchase silver clear underpants but have refused exclusion criteria: * patients that have a type v or type vi skin type according to the fitzpatrick scale (because these patients will likely have less radiodermatitis and if they do, it will be harder to evaluate it) the fitzpatrick scale: * type i (scores 0-7) white; very fair; freckles. always burns, never tans * type ii (scores 8-16) white; fair. usually burns, tans with difficulty * type iii (scores 17-25) beige; very common. sometimes mild burn, gradually tans * type iv (scores 25-30) beige with a brown tint; typical mediterranean caucasian skin. rarely burns, tans with ease * type v (scores over 30) dark brown. very rarely burns, tans very easily * type vi black. never burns, tans very easily 2) patients with an allergic reaction to alkagin paste

Keywords: patients with anal canal, low rectal or gynecological cancer
baclofen for anxiety and alcohol use disorder (aud): an open label study

Conditions: Alcohol Use Disorder (AUD)

Summary: the goal of this clinical trial is to determine the efficacy of baclofen for the treatment of alcohol use disorder (aud) in patients with or without comorbid anxiety symptoms. the main questions it aims to answer are: * do we see more abstinent days after the study period in patients with high anxiety symptoms compared to low anxiety symptoms? * do we observe additional differences between patients with high- and low anxiety symptoms in: any drinking at the end of treatment (yes/no), number of patients who respond to treatment, anxiety score reduction, autonomic responses, craving scores, drinking motives and side effects? participants already taking baclofen as part of routine clinical care for treatment of aud will be asked to answer several questionnaires over a 6 week study period.


Eligibility criteria:
inclusion criteria: * meeting dsm-5 criteria for aud * able to understand and provide written consent * already receiving baclofen or started with baclofen at start of hospitalization * therapeutic desire towards alcohol abstinence exclusion criteria: * concurrent substance use disorder other than nicotine or cannabis * clinically significant psychiatric illness that requires pharmacotherapy, unless stable and no changes in medication has been made in the last 30 days * clinically significant medical diseases that may pose a risk to continuing baclofen use * pregnant or currently breastfeeding women

Keywords: alcohol use disorder (aud) baclofen anxiety
carotid web associated with cerebral infarctions

Conditions: Carotid Arteries

Summary: carotid web located at the bulb level is a rare condition and is often associated with severe cerebral infarction in the carotid territory. this condition has been described predominantly in the black population. however, limited data are available for the epidemiology of carotid web and often result from selected population studies. it has been shown that the carotid web is a focal intimal dysplasia. rate of ischemic stroke recurrence is high, even in patients treated with antiplatelet therapy. this subtle lesion is often unknown and misdiagnosed including in stroke unit. we assume that the implementation of a multicentric cohort would allow a comprehensive analysis of the carotid web condition.

carotid web lesions associated with cerebral infarctions are a relatively rare and largely unknown disease. however, carotid web lesions are associated with severe infarction involving the functional and vital prognosis of patients. the high rate of recurrence should lead to an identification of the lesion at the first event in order to propose a suitable preventive treatment. we believe that only a multicenter cohort will be able to analyze the characteristics of the pathology and propose studies on critical size samples. a national cohort would lead quickly to a consequent collection of cases. by including overseas departments and communities, notions of prevalence and characteristics within different populations could finally be studied. participation to the cohort constitution will probably lead to sensitizing the various actors of the course of stroke care to the diagnosis and appropriate care of the carotid web. patients will be selected by the stroke units which take part in the cohort constitution. stroke unit investigator will fill the wepi online entry database. clinical, imaging and outcome characteristics will be informed. in order to guarantee the quality of the cases collected, the validation of the carotid web lesion will be carried out by a pair of expert neurologist - neuroradiologist appointed within an expert committee. in case of no consensus, a third expert will resolve the disagreement.

Eligibility criteria:
inclusion criteria: * age ≥18 years * available imaging revealing the presence of a carotid web * cerebral infarction or transient ischemic attack in the carotid area downstream of a carotid web lesion. * validation of the carotid web by a pair of experts neurologist and neuroradiologist * agreement of the patient or the support person given after reading the information and non-opposition form exclusion criteria: * age \<18 years * patient expressing opposition to be enrolled in the caroweb cohort

Keywords: carotid web cerebral infarction cohort
evaluation of short implants' success for teeth replacement in atrophic posterior mandibular ridge

Conditions: Alveolar Bone Loss

Summary: the aim of this study was to evaluate clinically and radiographically the splinted short implants' and single short implants' stability and bone condition before and after loading, in atrophic posterior mandibular alveolar ridges.

a prospective study was conducted on 16 patients with missing posterior molars. group a: 8 patients had 2 short implants placed in atrophic posterior mandibular alveolar ridge. group b: 8 patients had a single short implant placed in atrophic posterior mandibular alveolar ridge.

Eligibility criteria:
inclusion criteria: * missing posterior teeth, indicated for short implant placement. * residual alveolar ridge at 6-8 mm height and at least 7mm width. * healthy band of keratinized attached mucosa. * good oral hygiene. * medically fit patient, free from relevant diseases. exclusion criteria: * medically compromised patients. * imunnocompromised patients * patients with para-functional habits. * smokers * poor oral hygiene. * patient refuse to undergo the surgery.

Keywords: short implant splinted short implant
trial of transcranial direct current stimulation (tdcs) using alternative electrode montages

Conditions: Major Depression

Summary: among antidepressant treatments, ect stands as the most effective in treating acute depression. however, patient concerns with the cognitive side effects of ect have encouraged the development of new and more focal forms of brain stimulation such as transcranial direct current stimulation (tdcs). our current study of tdcs as a treatment for depression suggests that this technique has antidepressant effects and is safe, painless and well tolerated. however, not all patients may respond to this treatment in the way that it is currently administered and the concern of possible relapse in some patients who respond to tdcs has raised interest in finding alternative, possibly more optimal ways of administering tdcs. this study will investigate whether using alternative electrode montages can improve the antidepressant effects of tdcs in people suffering from depression.


Eligibility criteria:
inclusion criteria: 1. subject met inclusion criteria for study hrec 07305 (a sham controlled study of transcranial direct current stimulation (tdcs) as a treatment for depression). 2. subject completed study hrec 07305. 3. subject either did not reach remission at the end of trial (defined as madrs score of ≤ 10) or suffered an early relapse (within a month of finishing the trial). exclusion criteria: 1. diagnosis (as defined by dsm-iv) of: any psychotic disorder (lifetime); bipolar disorder; eating disorder (current or within the past year); obsessive compulsive disorder (lifetime); post-traumatic stress disorder current or within the past year); mental retardation. 2. history of drug or alcohol abuse or dependence (as per dsm-iv criteria) within the last 3 months (except nicotine and caffeine). 3. inadequate response to ect in the current episode of depression. 4. subject is on regular benzodiazepine medication which it is not clinically appropriate to discontinue. 5. subject requires a rapid clinical response due to inanition, psychosis or high suicide risk. 6. neurological disorder or insult, e.g., recent stroke (cva), which places subject at risk of seizure or neuronal damage with tdcs. 7. subject has metal in the cranium, skull defects, or skin lesions on scalp (cuts, abrasions, rash) at proposed electrode sites. 8. female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception (urine test for pregnancy will be used).

Keywords: depression direct current stimulation extracephalic electrode