Kornimate/medical-research-clean huggingface dataset:
the effect of sensorial biodex balance balance system exercises in diabetic neuropathy

Conditions: Diabetic Neuropathies; Diabetes Mellitus; Exercise Training

Summary: this study examined the effects of balance exercises performed with the biodex balance system (bbs) on nerve conduction, sensory symptoms, and muscle strength in patients with diabetes-related neuropathy.

we enrolled twenty-seven patients in this study. patients in the intervention group (n=14) performed exercises using the computerized bbs. the control group (n=13) was just informed about diabetes self-management. all patients underwent pretest and posttest peripheral nerve conduction studies. sensory examination performed by using 5.07 semmes-weinstein monofilaments and 128-hz tuning fork. muscle strength measurements obtained with manual dynamometer

Eligibility criteria:
inclusion criteria: * diabetes-related neuropathy based on laboratory tests, clinical findings, and nerve conduction study exclusion criteria: * increased risk of non-diabetes related neuropathy: history of autoimmune, cerebrovascular, or chronic infectious disease, cancer, chemotherapy and/or radiotherapy, radicular neuropathy, chronic kidney and liver failure, alcoholism or other substance abuse, and mental or physical disabilities (including blindness). we also excluded patients who didn't speak turkish
pilot study of tetomilast in chronic obstructive pulmonary disease (copd) associated with emphysema

Conditions: Chronic Obstructive Pulmonary Disease

Summary: phase 2a multicenter, randomized, double-blind, placebo-controlled study to assess the pharmacodynamics, efficacy, and safety of tetomilast in patients with emphysema.


Eligibility criteria:
inclusion criteria: * male or female, 40-75 yrs old,inclusive. * rating of greater than or equal to 1 on the goddard scale in assessment of emphysema severity by hrct. * fev1: fvc greater than 70% predicted. * at least 1 documented copd exacerbation within the past year but not within 8 weeks of randomization. * current or former smokers with a cigarette smoking history of at least 20 pack-years (or equivalent) and whose smoking status has not changed 60 days prior to screening. exclusion criteria: * patients with asthma, active tuberculosis or bronchiectasis. * a respiratory tract infection within 30 days prior to the screening visit. * any malignancy within the last 5 years with the exception of non-melanomatous skin cancer. * uncontrolled cardiovascular, endocrine, blood, or nervous system disorders. * uncontrolled condition with copd exacerbation of level 2 or 3 in the 8-week period prior to randomization. * systemic use of corticosteroids or other immunosuppressive agents within 30 days of the screening visit. * subjects taking anticoagulants.
comparison of the effects of a 12-week consumption of two carbonated beverages on insulin sensitivity

Conditions: Glucose Homeostasis

Summary: the purpose of this study is to determine whether consumption of carbonated drinks containing sweeteners affect insulin sensitivity.

sweeteners are natural or synthetic sugar substitutes which provide a sweetness taste to drink and food with few or no additional calories. sweeteners are widely used in commercialized beverages. despite some debate, no significant toxicity was demonstrated at a reasonable level of consumption (less than 20 cans per day). however little data is available on the metabolic effects of a regular consumption of beverages containing sweeteners. the objective of the study is to evaluate the effect of a regular consumption (twice a day for 12 weeks) of a carbonated drink with sweeteners, in a normal diet, compared with unsweetened sparkling water on insulin sensitivity in healthy normoweight and overweight subjects.

Eligibility criteria:
inclusion criteria: * healthy male or female * subject taking at least three main meals (breakfast, lunch, dinner) * subject able to understand and sign an informed consent * subject drinking and enjoying soft drinks * subject appreciating sweeteners taste * 19 kg/m² \< bmi\< 30 kg/m² exclusion criteria: * any severe or acute illness that may influence the results of the study or may be life-threatening * pregnant or breastfeeding subject * past or present metabolic or digestive diseases, with the exception of a possible appendectomy * diabetes or severe acute illness that may alter blood sugar * treatment that may interfere with glucose homeostasis * past or present kidney disease (renal failure, ... ) * local or systemic medication that may change water status, metabolism and feeding behavior * antiplatelet treatment * alcohol consumption ≥ 3-4 glasses / day ( ≥ 21 drinks / week ) * sustained physical exercise (more than 4 hours per week) * subject adding sweeteners (tablets or powder) in their diet * subject drinking more than two cans of drinks with sweeteners / day * subject dieting to lose weight * subject unable or unwilling to consume 2 liters of fluid / day

Keywords: sweetener, insulin, body mass index, physical activity
improving oral health with serious games

Conditions: Caries; Tooth Decay; Cavities; Gingivitis

Summary: this study investigated if computer games can be effective at changing the way children take care of their teeth. we a museum exhibit with 3d virtual reality games called "attack of the s. mutans!" our hypothesis was that children who played the games and visited the exhibit would show improved attitudes about oral health, which would translate into improved brushing and self-care habits. in this randomized controlled study with school children aged 8-12, we compared the outcomes for three groups: group 1) visited attack of the s. mutans!; group 2) experienced a hands-on classroom presentation about virtual reality being used for healthcare; group 3) received no-treatment.


Eligibility criteria:
inclusion criteria: for participation in the study, enrollment criteria are as follows: 1) a dentist's diagnosis of tooth decay, or restorative dental work in the previous year; and 2) parents or guardians provide usable baseline data, including contact information for follow-up questionnaires. exclusion criteria: none

Keywords: video games oral health social cognitive theory behavior change randomized trial growth modeling minority gender
psychological intervention using smartphone technology to alleviate malignant pain

Conditions: Cancer Pain; Opioid Use; Cognitive Behavior Therapy

Summary: the purpose of this study is to develop and pilot test a novel medical intervention (stamp+cbt app) that will help patients track their pain, mood, opioid use and side effects while delivering tailored education and self-management advice for patients with advanced cancer.

the primary purpose of this project is to determine the feasibility and acceptability of a novel mobile health application (stamp+cbt app). the stamp+cbt app (smartphone technology to alleviate malignant pain + cognitive behavioral therapy) seeks to provide education about pain medications alongside cognitive behavioral therapy techniques for pain to patients with advanced cancer. the application uses multi-media educational materials and survey algorithms assessing pain, medication usage, mood, stress, and sleep to improve pain management in this population. in this study, patients with advanced cancer at ou will participate in a single-arm, 6-week study of stamp+cbt (4-week intervention period and a 2-week post-intervention period).

Eligibility criteria:
cohort inclusion criteria: * age ≥ 18 years * patient diagnosed with an active cancer diagnosis (locally advanced solid tumor malignancy, multiple myeloma, or other advanced hematologic malignancy), either undergoing active treatment or receiving treatment for an advanced cancer or are receiving supportive care * chronic pain related to cancer or treatment (\> pain score of 4) * has an active prescription for at least one opioid medication to treat their cancer pain (i.e. not for post-surgical pain) * completed baseline survey cohort exclusion criteria: * patients in survivorship: patients who have completed their treatment regimens, are not actively receiving treatment for an advanced cancer, or have a cancer that is in remission * cognitive impairment that would interfere with study participation, as judged by treating clinician * inability to speak english (the intervention has not yet been translated to spanish) * enrolled in hospice * currently hospitalized * use of transmucosal fentanyl, given safety concerns and ongoing risk mitigation program required to prescribe these (tirf rems) * pain primarily related to a recent surgery (within the last 2 weeks) we will exclude adults who are unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant women, and prisoners.

Keywords: stamp (smartphone technology to alleviate malignant pain) cbt (cognitive behavioral therapy) mhealth (mobile health technology)
choir singing in aphasia rehabilitation

Conditions: Stroke; Aphasia

Summary: this study evaluates the verbal, cognitive, emotional, and neural efficacy of a choir singing intervention in chronic aphasic patients and their caregivers. using a cross-over rct design, half of the participants receive a 4-month singing intervention during the first half of the study and half of the participants during the second half of the study.

background: singing is a highly stimulating and versatile activity for the brain, combining vocal-motor, auditory, linguistic, cognitive, emotional, and social brain processes, both in the left and right hemisphere. the capacity to sing is often preserved in aphasia after stroke, and singing-based methods, such as melodic intonation therapy (mit), can be effective in rehabilitating speech production in aphasics. also emotionally and socially, singing could provide a powerful alternative channel for aphasic patients to express their emotions and interact with others, but the communal or group-level use of singing in aphasia rehabilitation has not been systematically studied. aims: the purpose of the study is to determine the clinical and neural efficacy of a novel choir singing intervention in subacute/chronic aphasia. specifically, the targeted outcomes are (i) verbal and vocal-motor skills, (ii) cognitive skills, (iii) emotional functioning and quality of life, (iv) caregiver psychological well-being, and (v) structural and functional neuroplasticity. in addition, the capacity of singing and music learning in aphasia is explored. methods: subjects are 60 stroke patients with at least minor aphasia (≥ 6 months post-stroke) and their family members (fms, n = 60) from helsinki area recruited to a cross-over rct study. participants are randomized to two groups \[n = 60 in both (30 patients, 30 fms)\], which receive a 16-week choir intervention either during the first (ab group) or second (ba group) half of the follow-up. the intervention is a combination of group training, which utilizes a novel combination of traditional senior choir singing and mit-like speech training protocols, and home training in which the choir material is trained with a tablet computer. all patients are evaluated at baseline, 5-month, and 9-month stages with language, cognitive, and auditory-music tests and questionnaires. half of the patients (n = 30) also undergo electroencephalography (eeg) and structural and functional magnetic resonance imaging (s/fmri). fms are evaluated with questionnaires.

Eligibility criteria:
the following inclusion criteria are used in patient recruiment: 1. age over 18 2. finnish-speaking 3. time since stroke \> 6 months 4. at least minor non-fluent aphasia due to stroke (bdae aphasia severity rating scale score ≤ 4) 5. no hearing deficit 6. no severe cognitive impairment affecting comprehension (the patient is able to understand the purpose of the study and give an informed consent) 7. no neurological / psychiatric co-morbidity or substance abuse 8. ability to produce vocal sound (through singing or humming).
the role of angiogenesis-related pathways in the development of port wine stains

Conditions: Port Wine Stain

Summary: 1. port wine stain (pws) is a congenital, progressive vascular malformation of human skin involving the superficial vascular plexus that occurs in estimated 3-5 children per 1,000 live births. in childhood, pws are flat red macules, but lesions tend to darken progressively to purple and, by middle age, often become raised as a result of the development of vascular nodules. because most malformations occur on the face, pws is a clinically significant problem in the majority of patients. 2. the late-stage cobblestoning appearance of pws subjects is comprised by not only pronounced vascular ectasia with proliferation of thin and/or thick-walled vessels and their stroma, but also numerous epithelial, neural and mesenchymal hamartomatous abnormalities. despite these histologic observations, the specific mechanisms involved in pws nodular formation remains unclear. 3. in one nodular pws subject, we found that phosphatidylinositol 3-kinases (pi3k)/protein kinase b (akt) and phosphoinositide phospholipase c g subunit (plc-g) were activated in both hypertrophic areas and nodules within the lesion. these observations led us to hypothesize that the pi3k pathway may play an important role in nodular formation.


Eligibility criteria:
inclusion criteria: * age 1 month - 70 years old, male or female; * the patient and the family of the child agreed to participate in the experiment and signed an informed consent form; * clinical diagnosis of refractory port wine stains with thickened nodular or pdl resistance; .there is no bleeding, ulceration, infection, etc. affecting the visual field of laser surgery operation. exclusion criteria: * patients with severe infectious diseases; * heart disease patients; * epilepsy patient; * pregnant patient; * researchers believe that patients who are not suitable for this experiment

Keywords: port wine stain, pi3k, vascular malformation,pdl
efficacy and safety of hippophae rhamnoides l. leaf extract on body fat

Conditions: Obesity

Summary: obesity is a major health issue worldwide; there is a constant raise in obesity related death each year. in vitro and animal studies elucidated hippophae rhamnoides l. leaf extract as a novel anti-obesity agent. however, the efficacy and safety of hippophae rhamnoides l. leaf extract supplementation on body weight regulation in humans are lacking.

the investigators performed a 12-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of hippophae rhamnoides l. leaf extract on body fat. the investigators measured body fat mass, percent body fat, fat free mass, weight, and body mass index.

Eligibility criteria:
inclusion criteria: * age between 19 and 65 years, * bmi 25\~29.9 kg/m2 or waist circumference ≥ 90(men), ≥ 85(women), * subjects giving written informed consent exclusion criteria: * bmi ≥ 30 kg/m2 * significant variation in weight(more 10%) in the past 3 months * cardiovascular disease, e.g. arrhythmia, heart failure, myocardial infarction, and patient with pacemaker * history of disease that could interfere with the test products or impede their absorption, such as gastrointestinal disease or gastrointestinal surgery * participation in any other clinical trials within past 2 months * laboratory test, medical or psychological conditions deemed by the investigators to interfere with successful participation in the study * pregnancy or breast feeding etc,.
comparison of different anterior cruciate ligament surgery techniques in skeletally immature patients.

Conditions: Anterior Cruciate Ligament Rupture

Summary: this cohort study compares to groups of patients with reconstruction of anterior cruciate ligament (acl). patients in group 1 had acl-reconstruction in the years 2001-2010 with a transphyseal drilling technique. patient in group 2 had acl-reconstruction in the years 2013-2018 with a physeal sparing technique. data including: x-ray exam, patient reported questionnaires and clinical evaluation will be compared between the 2 groups.


Eligibility criteria:
inclusion criteria: * acl reconstruction as skeletally immature exclusion criteria: * other ligament injuries in index knee * other ligament injuries in opposite knee * revision acl reconstruction * pregnant * not able to read or understand the danish languages
prognostic value of the selvester qrs score for perioperative myocardial injury following non-cardiac surgery

Conditions: Cardiac Ischemia; Cardiac Arrhythmia; Perioperative Injury; Perioperative Complication

Summary: the purpose of this study to determine the prognostic value of the selvester qrs score for perioperative myocardial injury following elective non-cardiac surgery.

this study was designed as an investigator-directed, non-commercial, observational, prospective, national, single-center study. the effect of preoperative complex ecg changes on the formation of cardiac damage will be studied. the data of the people participating in the study will be kept entirely confidential. after being informed about the study, all patients giving written informed consent will undergo preoperative evaluation. an ecg and cardiac troponin analysis will be performed to the patients who meet the eligibility. after the surgery will be completed control cardiac troponin and extensive physical examination will be performed.

Eligibility criteria:
inclusion criteria: * patients who undergoing elective non-cardiac surgery in the operating room * ≥18 years old * interpretable preoperative ecg of the patient * preoperative negative high sensitive cardiac troponin t * asa i-iii class * patients who give the informed consent exclusion criteria: * a history of myocardial infarction, coronary artery disease, pci and revascularization * a history of chronic renal disease, cerebrovascular incident, stroke * asa class iv * patients who do not give the informed consent * patients who undergoing emergency surgery * patients whose preoperative ecg is not interpretable * minor procedures to be performed outside or inside the operating room

Keywords: myocardial injury perioperative injury
intracochlear platelet-rich fibrin application in cochlear implantation

Conditions: Hearing Loss, Sensorineural

Summary: fibrosis due to surgical trauma is a common problem with cochlear implants. fibrosis limits the effectiveness of implant and increases the power consumption. our aim in this study is to benefit from the anti-inflammatory effects of autologous platelet-rich fibrin to reducing the fibrotic cascade.

the most common problem with cochlear implants is that their effectiveness decreases over time and they are not functional enough mainly due to fibrosis. our aim in this study is to benefit from the anti-inflammatory effects of autologous platelet-rich fibrin to reducing the fibrotic cascade. cochlear implant application will be performed under general anesthesia. after the postauricular incision and mastoidectomy, posterior tympanotomy will find the middle ear and from there the round window, and platelet fibrin prepared with the i-prf technique will be locally applied to the round window during the operation, and then implantation will be performed. the points where the electrode enters the cochlea will be covered with fascia. intraoperative nrt and impedances will be measured on all electrodes in all patients, and nrt and impedance measurements will be repeated in the 1st week, 1st month, 3rd and 6th months postoperatively. custom sound ep 5.0 (5.0.4.136) program provided by cochlear company will be used for these measurements.

Eligibility criteria:
inclusion criteria: * patients with sensorineural hearing loss * patients who will have cochlear implant surgery with ci422 electrode exclusion criteria: * patients with cochlear abnormality * patients with auditory neuropathy

Keywords: cochlear implant platelet rich fibrin
clinical benefits of a novel sleep-focused mind-body program on gulf war illness (gwi) symptoms

Conditions: Sleep Disturbance; Persian Gulf War Syndrome in Veteran

Summary: the purpose of this study is to investigate clinical benefits of a novel sleep-focused mind-body program on gulf war illness (gwi) symptoms.

this randomized study investigates whether two treatment conditions:mind-body bridging (mbb) and supportive education (sed) are effective in improving sleep disturbance and self-reported indicators of other co-morbid symptoms in veterans with gwi. the two treatment conditions will each comprise 3 sessions of 2 hr. duration and conducted over 3 consecutive weeks (week 1-3).

Eligibility criteria:
inclusion criteria: * veteran from first gulf war * suffering from sleep disturbance * has other chronic symptoms of gulf war illness: * fatigue * chronic headaches * joint/muscle pain * cognitive difficulties * memory/concentration problems * shortness of breath * gastrointestinal symptoms exclusion criteria: * terminally ill * a highly unstable medical or psychiatric condition * parkinson disease * dementia of any cause * nocturia * delayed/advanced sleep phase syndrome * narcolepsy
arthroscopic rotator interval closure in shoulder instability repair

Conditions: Recurrent Shoulder Dislocations

Summary: study title: arthroscopic rotator interval closure in shoulder instability repair - a prospective study objective: to evaluate the effect of arthroscopic rotator interval closure (aric) on patients with recurrent shoulder dislocations undergoing arthroscopic bankart repair (abr) in terms of recurrence, rehabilitation and function. hypothesis: 1. although hyperlax patients undergoing abr have higher incidence of recurrent shoulder dislocations than those without hyperlaxity, adding aric will lower the recurrent dislocation rate. 2. patients with arthroscopic bankart repair (abr) and aric are slower in gaining the range of motion (rom) but within 6 months are equal to those with abr only.


Eligibility criteria:
inclusion criteria: * age 16-40 years old * anterior shoulder instability * hyperlaxity (general and shoulder laxity) exclusion criteria: * previous humerus/glenoid fracture * large bony "bankart" * previous shoulder operation * adhesive capsulitis-habitual dislocations

Keywords: abd abduction abr arthroscopic bankart repair acj acromioclavicular joint ad anterior drawer aric arthroscopic rotator interval closure bl bankart lesion chl coracohumeral ligament er external rotation ff forward flexion ghj glenohumeral joint hsl hillsacs lesion ir internal rotation isp infraspinatus pd posterior drawer ri rotator interval rom range of motion sghl superior glenohumeral ligament ssc subscapularis ssp supraspinatus