Kornimate/medical-research-clean huggingface dataset:
characterization of chronic pain in elderly population with emphasis on differences between gender

Conditions: Elderly; Chronic Pain; Gender

Summary: introduction: it is estimated that by 2025 there will be approximately 1.2 billion people above 60 years old. global projections indicate that by 2050 there will be about 2 billion elders, 80% of them living in developing countries. researches on the relationship between pain and aging are currently much valued within the health sciences, the ultimate goal being the provision of adequate pain control for the growing number of elders in society. objectives: to characterize chronic pain in the elderly population and evaluate pain threshold to mechanical stimulation, with emphasis on gender differences. methods: this study refers to a cross-sectional study to be conducted in convenience samples of a primary care unit (geraldo horacio de paula souza) that follows elders and the department of geriatrics of the university hospital of the school of medicine of universidade de são paulo (hospital das clínicas). at least 200 participants of each gender, aged 65 or above, will be selected to participate. chronic pain will be that lasting for six or more months (either continuous or recurrent, as recommended by the international association for the study of pain). participants will be searched about their demographic and socioeconomic backgrounds, and asked to answer the following questionnaires: the mini mental state examination, a structured questionnaire for activities of daily living, a structured questionnaire for instrumental activities of daily living, beck anxiety inventory, geriatric depression scale, the five dimensions european quality of life assessment (eq5d) and brief pain inventory. participants will also be evaluated regarding pain threshold to mechanical stimuli using algometer. descriptive statistics of the sample will be displayed as means, medians, standard deviations and proportions. for testing for differences between males and females, a significance level of 5% will be used. keywords: elderly, chronic pain, gender.


Eligibility criteria:
inclusion criteria: * patient of the geriatrics clinic at the central institute (ic) of the hospital das clínicas da faculdade de medicina da universidade de são paulo (hcfmusp) or the geraldo horácio de paula souza school of public health center of the university of são paulo * be over 65 years old * accept study participation * have read, understood, agreed and signed the tcle exclusion criteria: * cognitive difficulty in understanding and responding to research questions * do not accept participation in the study
effects of global postural re-education (gpr) on patients with non-specific neck pain.

Conditions: Neck Pain

Summary: pain is an "unpleasant sensory and emotional experience (associated with actual or potential tissue damage". chronic pain is a sensation of hyperalgia to muscles, ligaments and skin on both active and passive movements. chronic pain has a tendency to prevent people from working and exercising

neck pain is a very common clinical condition which equals the economic, social cost and level of disability to that of low back pain.mechanical neck pain that occurs without an identifiable underlying disease and anatomical abnormality is termed as "non-specific" neck pain (ns-np).mechanical neck pain commonly arises insidiously and is generally multifactorial in origin.two most common complains associated with chronic specific and non-specific neck pain are kinesiophobia (fear of movement) and postural asymmetry (forward head posture). medical, surgical and physical therapy treatments are recommended for addressing chronic non-specific neck pain. within the scope of physical therapy conventional management consist of many different techniques such as therapeutic exercises, electrotherapy, pilates, yoga and manual therapy. manual therapy is among the most common used method for treating musculoskeletal conditions including chronic neck pain. manual therapy consists of stretching techniques, joint mobilization/manipulation, isometric/dynamic strengthening exercises and fascial manipulation or release. global postural re-education (gpr) is an alternative therapeutic strategy based on the concept that postural muscles are organized in the form of 'muscle chains' located on the anterior and posterior aspect of the spine. it involves the global stretching of the anti-gravitational muscles and the kinetic muscle chains.

Eligibility criteria:
inclusion criteria: * chronic non-specific neck pain ≥ 3 months. * no prior medication and physical therapy interventions from last 3 months. * pain: moderate level (6 on nprs). exclusion criteria: * history of any trauma . * history of any psychological condition. * specific causes of neck pain (e.g., systemic, rheumatic, neuromuscular diseases). * presence of central and peripheral neurological sign. * spinal surgery

Keywords: pain range of motion kinesiophobia forward head posture
selective unilateral spinal anesthesia versus selective sensory spinal anesthesia for knee arthroscopy surgery

Conditions: Pain

Summary: background: selective unilateral spinal anesthesia is the gold standard spinal anesthesia technique for knee arthroscopy. selective sensory spinal anesthesia has recently been validated for this surgery. both selective techniques are specially indicated for ambulatory surgery because of pacu fast track, low discharge home time and high patient satisfaction. this study compares both spinal techniques for knee arthroscopy surgery.


Eligibility criteria:
inclusion criteria: * adults scheduled to undergo knee arthroscopy exclusion criteria: * a previous history of neurological impairment * insulin-dependent diabetes mellitus * intolerance to the study drug or related compounds and additives * bmi \> 38 kg/m2 * height \ 180 cm * any existing contraindications for spinal anaesthesia * surgery in which a complete block of the lower limb

Keywords: knee arthroscopy hyperbaric bupivacaine hypobaric levobupivacaine plus fentanyl
evaluation of the diagnostic of hepatic fibrosis with the in severe obese patients candidates to bariatric surgery

Conditions: Steatosis; Obesity; Fibrosis, Liver

Summary: background: the xl probe of fibroscan was recently developed to realize liver stiffness measurements (lsm) in overweight patients. severe obese patients have a high prevalence of liver injuries and could benefit of liver evaluation prior to bariatric surgery. objectives: assess the fibroscan applicability, reliability and diagnostic performances in severe obese patients' candidates for bariatric surgery.


Eligibility criteria:
inclusion criteria: * severe obese patients candidate to bariatric surgery with no history of liver disease have a large prevalence of liver lesions.
evaluation of a patient warming concept following the german s3 guideline for prevention of intraoperative hypothermia

Conditions: Hypothermia; Hypothermia, Accidental

Summary: the aim of the study is to evaluate a patient prewarming concept following the recommendations of the s3-guideline "prevention of perioperative hypothermia" with respect to incidence and complications of perioperative hypothermia. the study hypothesis is that postoperative core temperature in adult patients after prewarming is significantly higher than in patients who were treated following actual standard protocol (passive insulation).

the aim of the study is to evaluate a patient prewarming concept following the recommendations of the new german s3-guideline "prevention of perioperative hypothermia" with respect to incidence and complications of perioperative hypothermia. prewarming should enable the patients to preserve their core temperature for a longer period and to avoid perioperative hypothermia.the study hypothesis is that postoperative core temperature in adult patients after prewarming is significantly higher than in patients who were treated following the actual standard protocol (passive insulation).

Eligibility criteria:
inclusion criteria: * patients scheduled for elective general or orthopedic surgery with expected duration \> 45 min * american society of anesthesiologists physical status 1-3 * age \> 17 years exclusion criteria: * emergency surgery * patient's denial * unexpected decrease of duration of anesthesia \< 45 min * preoperative body temperature \> 38 °c

Keywords: perioperative hypothermia prewarming treatment guideline
sfi bars and milled bars supporting mandibular overdentures. three-year randomized clinical trial

Conditions: Edentulous Alveolar Ridge in Mandible

Summary: the aim of this study will be to evaluate the marginal bone loss and prosthetic complications of stress-free implant (sfi) and milled bars used to assist mandibular 4-implant overdentures after 3 years

eight edentulous participants with insufficient stability of mandibular dentures will receive 4 implants in the mandibular ridge (2 implants in the canine areas and 2 implants in the first molar areas), and then after 3 months, patients will be randomly assigned into 2 groups; 1) group 1: will include 4 participants who will receive milled bar overdentures, and 2) group 2: will include 4 participants who will receive sfi bar overdentures. for both groups, marginal bone loss will be evaluated using the standardized digital periapical films at the time of insertion, 6 months, 1 year, and 3 years after insertion. prosthetic and mucosal complications will be evaluated after 3 years.

Eligibility criteria:
inclusion criteria: * mandibular edentulous ridge exclusion criteria: * severe atrophy in mandibular ridge

Keywords: sfi bar milled bar bone loss mucosal complications prosthetic complications
effect of riluzole as a symptomatic approach in patients with chronic cerebellar ataxia

Conditions: Hereditary Ataxia; Multiple Sclerosis; Cerebellar Ataxia

Summary: cerebellar disorders are often disabling and symptomatic therapies are limited to few options that are partially effective. it seems therefore appropriate to search for additional approaches. purkinje cells are the sole output of the cerebellar cortex: they project inhibitory signals to the deep cerebellar nuclei (dcn), which have a critical role in cerebellar function and motor performance. dcn neurons fire spontaneously in the absence of synaptic input from purkinje neurons and modulation of the dcn response by purkinje input is believed to be responsible for coordination of movement. recent evidences support the notion that an increase in dcn excitability may be an important step in the development of cerebellar ataxia and point to the underlying molecular mechanisms: the inhibition of small-conductance calcium-activated potassium (sk) channels, that causes an increase of the firing frequency in dcn, correlates with cerebellar ataxia. the rationale of the present project is that sk channel openers, such as riluzole, may have a beneficial effect on cerebellar ataxia. the researchers propose to perform a pilot study investigating safety and efficacy of riluzole, an approved treatment for amyotrophic lateral sclerosis, as a symptomatic approach in patients with chronic cerebellar ataxia.

forty patients with chronic cerebellar ataxia will be enrolled in a double-bind, randomized, placebo-controlled trial. by central randomisation, patients will take 50 mg of riluzole or placebo twice daily for 8 weeks. electrocardiogram routine laboratory tests and pregnancy tests will be performed before drug administration, after 4 weeks of treatment and at the end of the study (after 8 weeks of treatment). at the same time points the international cooperative ataxia rating scale (icars) for pharmacological assessment of the cerebellar syndrome will be administered to the two groups (riluzole and placebo) of patients. to guarantee the evaluation of the results in blind conditions, the neurologists who will evaluate the icars scores will be different from those who will deal with randomisation and follow-up of patients.

Eligibility criteria:
inclusion criteria: * patients with cerebellar degeneration (heredoataxias, sporadic idiopathic ataxia, multiple system atrophy type c) * patients who meet mcdonald criteria for probable or definite multiple sclerosis (ms) with chronic cerebellar ataxia (not acute cerebellar ataxia due to relapse) * age between 18 and 80 years exclusion criteria: * ataxia due to other diseases * acute cerebellar ataxia * use of other drugs for chronic ataxia * serious concomitant illnesses (cardiac arrhythmias, haematological and hepatic diseases) * pregnancy or breast feeding

Keywords: cerebellar ataxia deep cerebellar nuclei (dcn) small-conductance calcium-activated potassium(sk)channels riluzole sporadic ataxia multiple system atrophy type c
the cohort study of the correlation between serum 25(oh)d level and pregnancy outcome

Conditions: Vitamin D Deficiency; Recurrent Miscarriage; Pregnancy Related

Summary: the objective of this single-center prospective observational study is to clarify the trend of maternal serum 25(oh)d levels before pregnancy and during pregnancy, and to explore the correlation between serum 25(oh)d levels and subsequent pregnancy outcomes of patients with abortion, so as to provide certain scientific evidence for finding the optimal serum level of 25(oh)d and optimal vitamin d supplementation to maintain a healthy pregnancy.

women of reproductive age who meet the inclusion criteria are recruited from the outpatient department of renji hospital from november 2022 to december 2023. subjects fill in the basic information at the outpatient clinic. after being included in the study, peripheral blood is collected before and during the first trimester (\< 10 weeks), second trimester (22-24 weeks) and third trimester (32 weeks) to detect 25(oh)d, calcium, phosphorus and pth levels. b-ultrasound examination is performed before pregnancy to record endometrial thickness, endometrial hemodynamic index (pi, ri and s/d) and uterine arterial hemodynamic index (pi, ri and s/d) during the luteal phase. data are comprehensively analyzed through questionnaire form filling, laboratory examination, and clinical information records including pregnancy outcomes (final live birth rate, cesarean section rate, pregnancy loss rate, etc.), obstetric complications, and neonatal delivery information.

Eligibility criteria:
inclusion criteria: * ≥20 years old * the chromosome karyotype of the couple is normal * color ultrasound examination results indicated that there was no organic disease related to reproductive tract * no serious complications of surgery and medicine * agree and voluntarily sign informed consent exclusion criteria: * there are contraindications to pregnancy * the initiative to give up pregnancy * severe medical and surgical complications, for example, liver disease was defined as serum alanine aminotransferase \[alt\] or aspartic aminotransferase \[ast\]\>3 x upper normal limit \[uln\] after repeated testing * concomitant malignant tumor, malignant tumor developed in the last 5 years (except for the skin squamous basal cell carcinoma that has been removed and considered cured). subjects who developed malignant tumors more than 5 years ago should provide evidence of remission or cure. subjects with a history of cervical cancer were eligible if they could demonstrate that their cervical cancer had been cone removed or cured within the past 3 years * known human immunodeficiency virus (hiv) positive and/or hepatitis b surface antigen or hepatitis c virus antibody positive at screening visit * with a history of chronic infections such as mycoplasma, chlamydia, cryptococcus, and invasive fungal infections should be discussed with the principal investigator

Keywords: vitamin d pregnancy recurrent spontaneous abortion
physiotherapy and osteopathy on infant colic

Conditions: Infantile Colic; Manual Therapy

Summary: this study compares the effectiveness of manual therapy (osteopathy) on infant colic versus education to the family, and a third group with no specific intervention.

infant colic is a problem that affects 10-30% of babies in their first months of life. this research project aims to verify the effectiveness of manual therapy on infant colic. the sample is divided in three groups, performing in the firts one osteopathy manual therapy; in the second one, measures to support and education to the family; and in the third, there is no specific intervention.

Eligibility criteria:
inclusion criteria: * being diagnosed if infant colic. exclusion criteria: * babies diagnosed of other pathologies that justify cries, such as reflux, food intolerances or neurological syndromes. * premature babies less than 37 weeks gestation, who may be involved in other concomitant pathologies. * mothers (families) with language barriers, due to the difficulty of collecting data.

Keywords: infant colic osteopathy stress physiotherapy
a research study to compare the treatments of a combination of elzasonan with zoloft, to zoloft alone, or placebo in people with major depressive disorder (mdd)

Conditions: Depressive Disorder, Major

Summary: the major purpose of the study is to help determine whether giving the combination of elzasonan with zoloft to people with depression is a better treatment than taking zoloft alone. this study will also compare the safety and tolerability of elzasonan and zoloft combination to zoloft alone or placebo.


Eligibility criteria:
inclusion criteria: * adult subjects, 18 years of age or older with a diagnosis of recurrent, moderate-to-severe mdd without psychotic features (dsm-iv 296.3x, with a hamd17 score \>= to 22 and cgi-s \>=4. * mdd must be the primary psychiatric disorder that motivated the subject to seek treatment and the current episode must be at least 1 month in duration but no longer than 6 months in duration. exclusion criteria: * subjects who, in the investigator's judgement, would require treatment with electroconvulsive therapy (ect), or antipsychotics, or would require a change in intensity of psychotherapy, or subjects who would require treatment with any other psychotherapeutic drugs during the course of the trial. * subjects who have ever been diagnosed with panic disorder, post-traumatic stress disorder, obsessive-compulsive disorder, bipolar affective disorder, schizophrenia, schizoaffective disorder or othe psychotic disorder, mdd with a seasonal pattern, or dissociative disorders per dsm-iv criteria.
to evaluate the efficacy and safety of aspherical soft contact lens in myopia control

Conditions: Myopia

Summary: the objective of this study is to demonstrate that the ticon aspherical daily disposable soft contact lens could retard myopia progress in youth

this study is designed as a prospective, multicenter, randomized, double blinded, controlled, paired-eye comparison study. at least 60 evaluable subjects with myopia progression ≧ 0.75 d in the past 12 months will be recruited from 2 study sites. the experimental soft contact lens with aspherical design (ticon aspherical) will be randomly assigned to either the right eye or the left eye of the subject , then the fellow eye will be assigned a control lens with a single vision distance (svd) soft contact lens (ticon). both lenses will be worn at least 8 hours a day, 5 days a week for 1 year. all lenses will be replaced every day. brief assessment of the clinical findings will be followed up for one year at 1 day, 1 week, 1, 3, 6, 9, 12 months upon allocation. the primary efficacy outcome is change in spherical equivalent refraction (ser) measured by cycloplegic autorefraction over 12 months. the secondary outcome is change in axial eye length (axl) measured over 12 months. the secondary outcome measure is used to corroborate any changes in ser

Eligibility criteria:
inclusion criteria: * myopia (se) between -1.00d to -8.00d * astigmatism less than or equal to 1.75d * myopia progression ≧0.75 d in the past 12 months * best corrected visual acuity (bcva): 0.9 snellen or better * willingness to wear contact lens constantly * availability for follow-up for at least 1 year * parent's understanding and acceptance * have an acceptable surrogate capable of giving legally authorized consent on behalf of the subject exclusion criteria: * anisometropia greater than 2.00d * presence of ocular disease preventing wear of contact lens * severe ocular or systemic allergies * taking any medication that might have an impact on contact lens wear or that might influence the outcome of the clinical trial * ocular or systemic condition that might affect refractive development * atropine/pirenzepine treatment for myopia control in the past 1 month * prior use of ortho-k lenses * dry eye with schimer test (basal secretion test) \< 5mm/5min or other physical condition that would contraindicate contact lens wear

Keywords: myopia control soft contact lens eye diseases
to demonstrate equivalence in analgesic efficacy & bowel function between oxn pr higher dose & lower dose tablet strengths in subjects with non-cancer or cancer pain

Conditions: Malignant Pain; Non-malignant Pain

Summary: this study is aimed to demonstrate equivalence between combinations of lower strength oxn pr tablets (oxn pr lst) and single higher strength oxn pr tablets (oxn pr hst) taken at the same overall daily dose.

study oxn3508 is a multicenter double-blind, double-dummy, randomised, cross-over, 2-period, phase iii study in male and female subjects with severe non-malignant or malignant pain that requires around-the-clock opioid therapy at a daily dose of 120/60 mg or 160/80 mg oxycodone/naloxone prolonged release (oxn pr).

Eligibility criteria:
inclusion criteria * subjects who are receiving who step iii opioid analgesic medication for the treatment of non-malignant or malignant pain. * documented history of non-malignant or malignant pain that requires around-the-clock opioid therapy exclusion criteria * females who are pregnant or lactating. * subjects with evidence or significant structural abnormalities of the gastrointestinal tract. * subjects with evidence of impaired liver/kidney function upon entry into the study.

Keywords: oxycodone naloxone combination severe chronic and non-malignant pain malignant and non-malignant pain that requires around-the clock opioid therapy
clearance of intracranial blood products by continuous irrigation with the irraflow system

Conditions: Intracranial Hemorrhage; Ventriculitis; Intracranial Abscess

Summary: the study is a multi-center prospective cohort, controlled, phase 4 post-market registry evaluating the efficacy and radiographic outcomes associated with the use of the irraflow® active fluid exchange system compared to standard of care external ventricular drains.

the irraflow system offers automated irrigation, controlled drainage, and icp monitoring all in one system for the treatment of intracranial hemorrhage - \[intracerebral hemorrhage (ich), intraventricular hemorrhage (ivh), subarachnoid hemorrhage (sah), subdural hematoma (sdh)\], intracranial abscess, and ventriculitis. the analysis of the irras catheter will occur prospectively if it is determined the patient meets the enrollment criteria. all patients enrolled in the trial will receive additional supportive and medical treatment by choice of the treating physician and in accordance with standard of care. such treatment includes but is not limited to neurointensive care, neuromonitoring, and surgical or endovascular occlusion of identified sources of intracranial hemorrhage (e.g. vascular anomalies, aneurysms, etc.).

Eligibility criteria:
inclusion criteria: * age \>=18 years of age * intracranial hemorrhage documented on head ct or mri scan. * indication for active fluid exchange evaluated by treating physician. * signed informed consent obtained by patient or legal authorized representative * scheduled enrollment and treatment within 72 hours of last known well (lkw) exclusion criteria: * gcs ≤ 5 * pregnancy * fixed and dilated pupil * life-threatening medical condition