Kornimate/medical-research-clean huggingface dataset:
therapeutic response evaluation by ctc expansion system

Conditions: Circulating Tumor Cells

Summary: among biomarkers, ctcs are a convenient, sensitive and biologically informative option. ctc detection could be considered a real-time "liquid biopsy" approach and contains several advantages such as minimally invasive, easy and safe to perform, and multiple samples can be taken over time, better prognosis to indicate an elevated risk of metastases, improved therapy monitoring, providing live disease status information., however, the number of ctcs is very low, so the establishment of cell culture from ctcs becomes the most challenging over the past year. in this study, we develop a short-term ctc expansion protocol combined with a new surface coating technique. expanded circulating tumor cells will provide genetic information and develop oncology drug screening platform, which provides an opportunity to monitor response to therapy noninvasively.

ctc detection could be considered a real-time "liquid biopsy" approach and contains several advantages such as minimally invasive, easy and safe to perform, and multiple samples can be taken over time, better prognosis to indicate an elevated risk of metastases, improved therapy monitoring, providing live disease status information., however, the number of ctcs is very low so the establishment of cell culture from ctcs becomes the most challenging over the past year. in this proposal we will develop a short-term ctc expansion protocol through combine with a new type of surface coating technique. expanded circulating tumor cells will provide genetic information and develop oncology drug screening platform which provide an opportunity to noninvasively monitor response to therapy.

Eligibility criteria:
inclusion criteria: * patients with malignant tumors exclusion criteria: * unsuitable for recruitment by clinical judgement or non-compliance with regular follow-up.
use of simvastatin for the prevention of vasospasm in aneurysmal subarachnoid hemorrhage

Conditions: Aneurysmal Subarachnoid Hemorrhage; Cerebral Vasospasm

Summary: the purpose of this study is to test whether treatment with a drug called simvastatin prevents and improves outcome in patients who have subarachnoid bleeding. simvastatin is currently approved for the treatment of high cholesterol levels.

aneurysmal subarachnoid hemorrhage or sah (bleeding on the surface of the brain) affects 10 per 100,000 population each year. for survivors of the initial hemorrhage, delayed narrowing of the blood vessels (vasospasm) and related delayed strokes are the most common serious complication. narrowing of blood vessels affect 30% of patients with such bleeding. despite maximum therapy, nearly 50% of patients with symptomatic vasospasm with develop stroke. because cerebral vasospasm remains the leading cause of morbidity and mortality after asah, this critically important issue needs further studies. one hundred and fifty patients will be randomized, 50 to each arm of the study. patients enrolled in the study will be receive the drug (either simvastatin 40 mg or simvastatin 80 mg per mouth daily), while the control group will receive a sugar tablet. the treatment will be continued for a total of 21 days. the neurological abilities (stroke outcome measures, these are included with the application for your review) at day 21 post asah will be reviewed at time of discharge as well at 6 months of follow up.

Eligibility criteria:
inclusion criteria: * 18-85 years old inclusive * subarachnoid hemorrhage diagnosed by ct on admission * randomizable within 732 hours of subarachnoid hemorrhage * saccular intracranial aneurysm proven by cerebral angiography or computed tomographic angiography (cta) * surgical or endovascular obliteration * able to obtain written informed consent from patient or surrogate exclusion criteria: * pregnancy, as confirmed by routine urine test on admission * elevated liver function test at time of randomization, defined as more than three times the upper limit of normal * on statins, niacin, or fibrate therapy within 30 days of presentation * any vasospasm on the initial diagnostic angiogram * glasgow coma scale 5 or less at the time of randomization * history of liver disease or active liver disease * hypersensitivity to statins * patient taking medication not recommended for concomitant use with simvastatin (40 or 80 mg) as per the product label

Keywords: sah vasospasm
improving the diagnosis of meningitis in emergency rooms

Conditions: Meningitis

Summary: a point-of-care laboratory (poc) was set at north hospital, marseille, france for the diagnosis in less than two hours of meningitis caused by known pathogens, close to the reception of emergency service. in this instance 30% of patients have no etiological diagnosis after the poc diarrhoea tests . this lab has discovered over 200 new species of bacteria in humans, including vector bacteria and opened the field of large deoxyribonucleic acid (dna ) viruses. also, the laboratory of emerging viruses discovered many ribonucleic acid (rna) viruses transmitted by arthropods. based on this collection of new pathogens described in poc laboratory, this study proposes to expand the etiological diagnosis strategy of meningitis after poc test.


Eligibility criteria:
inclusion criteria: * patient admitted at hospital for meningitis requiring, for the emergency physician, a microbiological examination with a "poc meningitis kit." * patient who has freely signed the informed written consent * patient affiliated to a social security scheme exclusion criteria: * pregnant woman, parturient or nursing * adult patient under guardianship * patient deprived of liberty under court order * patient refusing or unable to sign the informed consent form.
laparoscopy-assisted proximal gastrectomy versus and laparoscopy-assisted total gastrectomy

Conditions: Gastric Cancer

Summary: the choice of surgical strategy for patients with proximal gastric cancer is controversial mainly because proximal gastrectomy is infamous for high rates of reflux symptoms and anastomotic stricture. but there are no prospective randomized trials until now. the primary end point of this study is whether the rate of reflux esophagitis is different or not between lapg and latg. through this study, we

prospective randomized clinical trials between laparoscopy-assisted proximal gastrectomy and laparoscopy-assisted total gastrectomy. lapg reconstruction: double tract reconstruction (3 anastomosis, intracorporeal roux-en y esophago-jejunostomy, extracorporeal gastro-jejunostomy 10cm below esophago-jejunostomy,extracorporeal jejuno-jejunostomy 20cm below gastro-jejunostomy) latg reconstruction: intracorporeal roux-en y esophago-jejunostomy primary end point : incidence of reflux esophagitis after operation sample size : lapg 97 cases, latg 97 cases (p1=0.018 p2=0.018, a=0.05, b=0.80) non-inferiority test, non-inferior margin (delta) : 0.05. sample size calculated by our mrcc(medical research collaborating center, http://mrcc.snubh.org) study duration : 48 months (enrollment 36months, follow-up 12months) reflux esophagitis evaluation methods 1. ambulatory 24hr-ph esophageal holter monitoring for acid reflux 2. disida scan for bile reflux 3. endoscopic evaluation (grading according to la classification) 4. visick score (subjective symptoms) 5. eortc sto 22 and giqli evaluation (quality of life) 6. nutritional benefits (body weight, triceps skin folds thickness, blood test) 7. upper gastrointestinal study 8. gastric emptying scan

Eligibility criteria:
inclusion criteria: * age 20\~80 * informed consent * no other malignancies * proximal gastric cancer met by following conditions 1. lesion located on proximal stomach (upper one third) 2. lesion below 5cm in size 3. lesion confined to proper muscle depth (ct2) 4. no evidence of metastatic enlarged ln on #5, 6, 4d, 10 basins and other distant metastasis. (cn1) exclusion criteria: * if patients is only suitable to total gastrectomy, he will be excluded.

Keywords: gastric cancer proximal gastrectomy total gastrectomy laparoscopy reflux esophagitis double tract reconstruction
parents' experience of child loss during pregnancy or birth

Conditions: Stillbirth and Fetal Death; Miscarriages; Experience

Summary: the investigators are conducting a participatory study with and for parents after child loss during pregnancy or birth. their aim is to develop treatment recommendations for healthcare professional. these focus on question, how to deal with parents when experiencing child loss.

the entire study is following a participatory approach and including parents after stillbirth in the research team. along a co-creative design, the investigators planned a multistep-explorative mixed-methods study. in detail, three key steps will be conducted. first, workshops and focus groups will be carried out to identify central needs of affected parents. afterwards, one investigator will interview the parents narratively to gain an in-depth understanding of their experiencs. finally, these findings will be summarized and translated into treatment recommendations for healthcare professionals.

Eligibility criteria:
inclusion criteria: * german speaking * living in austria, germany or switzerland * child loss during pregnancy or birth * child loss within last 12 months * legal capacity * voluntary participation exclusion criteria: * loss of child after birth * not speaking and understanding german * not in a good mental condition to participate

Keywords: pregnancy loss child loss qualitative research mixed-methods experience need parents perinatal loss fetal death miscarriage stillbirth
comparison of the gma-tulip and i-gel laryngeal mask for airway management in general anaesthesia: a randomized controlled trial

Conditions: Trauma Surgery; General Anesthesia

Summary: the goal of this clinical trial is to learn if gma-tulip laryngeal mask willfit well in the right place in participants undergoing trauma surgery in a supine position under general anaesthesia. it will also learn about the convenience, effectiveness and safety of the gma-tulip laryngeal mask. the main questions it aims to answer are: does the gma-tulip laryngeal mask exhibit better anatomical alignment? does the gma-tulip laryngeal mask perform effectively in trauma surgery patients in a supine position under general anaesthesia? researchers will compare with the i-gel laryngeal mask (a device already popular among anaesthetists) to see if the gma-tulip laryngeal mask works to have a good performance in general anaesthesia. participants will describe feelings immediately after anesthesia， 1 hour later and 24 hours later.


Eligibility criteria:
inclusion criteria: 18 years old ≤ age ≤ 70 years old. patients undergoing trauma surgery in a supine position under general anesthesia. 18 kg/m2 ≤ bmi ≤ 35 kg/m2. american society of anesthesiologists (asa) grades i-iii. can understand the research process and the use of pain scales. clear understanding and voluntary participation in the study, signing of informed consent form. exclusion criteria: patients with known or predicted difficult airways. high risk of reflux or aspiration (e.g., gastroesophageal reflux disease patients). individuals with active upper respiratory tract infections. cervical related diseases or surgical history. preoperative sore throat or previous sore throat or hoarseness. patients with oral and maxillofacial trauma or fractures. other reasons why researchers believe it is not appropriate to participate in the experiment.

Keywords: gma-tulip laryngeal mask i-gel laryngeal mask anatomical alignment of laryngeal mask oropharyngeal leak pressure
the effect of pregnancy on temporal summation and venipuncture pain perception

Conditions: Pain; Pregnancy

Summary: recent studies have shown that women are more likely to experience pain in many medical situations. during pregnancy, women may experience an increase in pain threshold. this is thought to be related to hormonal changes and an increase in the level of certain natural pain-relieving substances in their bodies. it is important to develop simple tests to identify woman at higher risk for pain so the investigators can help them. temporal summation is what happens when a person becomes more sensitive to a certain feeling on their skin when it is applied several times over the course of several seconds. the investigators hypothesize that pregnant women show decreased temporal summation and pain scores to venipuncture, compared to non-pregnant women.

recent epidemiologic studies have shown that women are at substantially greater risk for many clinical pain conditions, and there is a suggestion that postoperative and procedural pain may be more severe among women then men. during pregnancy, women experience an elevation in the threshold to pain and discomfort. in addition to hormonal changes, the changes in pain perception during pregnancy may be related to an increase in endogenous opioids. pain is the most feared experience in the intra and postpartum period, and severe pain experienced during this time can lead to significant morbidity, including chronic pain and depression. much attention has been paid to tests that can predict patients at higher risk for pain. temporal summation (ts) has been shown to be a simple and reliable test. temporal summation represents the physiological wind-up phenomenon taking place at the spinal level of the central pain pathways. ts extent can be measured in humans by administering a series of noxious stimuli of constant intensity and of various modalities in order to evoke an increase in perceived pain. it is a very simple and easy test to perform, and very well tolerated by patients. whether ts changes in pregnancy and whether ts in pregnancy correlates with pain perception during acute stimuli such as venipuncture is unknown.

Eligibility criteria:
inclusion criteria: * informed consent * able to communicate in english * healthy pregnant patients in the 1st, 2nd and 3rd trimesters * healthy non-pregnant patients exclusion criteria: * refusal to participate * patients under age 18 or over age 40 * inability to communicate in english * use of analgesics, anti-depressants and muscle relaxants * self-report of substance abuse * previous injury to the non-dominant arm/forearm

Keywords: temporal summation venipuncture pain
school partnered collaborative care (space) intervention for children with type 1 diabetes

Conditions: Type 1 Diabetes

Summary: this is a pilot trial of a school-partnered collaborative care (space) model for pediatric type 1 diabetes. the trial will investigate the feasibility and acceptability of space for children with type 1 diabetes in the school setting. space is adapted from a collaborative care model used to treat depression and other mental health care conditions in adolescents and adults.

this pilot cluster randomized controlled trial will examine the feasibility of a school-partnered collaborative care (space) model for children with type 1 diabetes (space for t1d). school districts will be randomized to the intervention or control arm in a 2:1 allocation ratio. school districts randomized to the control arm in year 1 of the study will be invited to participate in space in year 2. all children with type 1 diabetes meeting inclusion criteria in each school district will be approached to participate through their school nurse. all research activities will be conducted using a virtual video-conferencing platform. the intervention arm will consist of four monthly virtual meetings between the child, school nurse, diabetes care and education specialist (dces), and any other identified school-related support people. the purpose of these meetings will be to determine a shared treatment plan, make treatment recommendations, and determine progress towards meeting the child's goals. the control arm will receive usual care in the school and the clinical setting as well as monthly phone calls from the dces to the parent to offer review of blood glucoses. no additional contact with the school will be offered. participants and their parents will be asked to complete surveys regarding their overall health and well-being and provide us access to their glucometer/continuous glucose monitor data. additional information will be collected from the electronic health record (hemoglobin a1c, care utilization, referrals). at the end of study, surveys for the parent and school nurse will assess feasibility and other implementation outcomes.

Eligibility criteria:
inclusion criteria: * diagnosis of type 1 diabetes for at least 6 months * attend school in one of the partnered school districts * receive daily oversight from the school nurse for their diabetes * managed by the children's hospital of pittsburgh diabetes center * able to participate in english exclusion criteria: * child has developmental delay or neuropsychiatric disorder which would preclude their participation in their diabetes care and/or completion of study questionnaires * child is completely independent in diabetes care in school

Keywords: school collaborative care model diabetes care and education health services
prevention of edema after coronary artery bypass graft by customized pressure-guided elastic bandages

Conditions: Limb Edema; Surgical Site Infections; Leg Swelling; Compression Bandages; Coronary Artery Bypass Graft; CABG; Saphenectomy; Saphenous Vein; Delayed Wound Healing; Post Operative Complications; Post Operative Surgical Site Infection

Summary: the study aimed to assess the efficacy of customized pressure-guided elastic bandages (cpg-eb) in preventing postoperative edema and complications in coronary artery bypass graft (cabg) patients. while compression therapy, like compressive stockings, has benefits in preventing edema, concerns about affordability persist. cpg-eb provides optimal sub-bandage pressure, proven effective in venous leg ulcers. implementing cpg-eb post-cabg could enhance venous blood flow, reducing complications and improving outcomes. patients were divided into two groups: one with cpg-eb and the other standard post-cabg care. data collected at 1, 2, and 6 weeks post-surgery assessed swelling and wound complications. comparative analysis used standardized criteria.

inclusion criteria : 1. all patients scheduled for elective coronary artery bypass grafting (cabg) surgery with saphenous vein harvesting from the leg at siriraj hospital. 2. patients aged 18 years and older undergoing cabg surgery with saphenous vein harvesting from the leg at siriraj hospital, who willingly consent to participate in the study. exclusion criteria : \* 1. patients with an ankle-brachial pressure index (abi) \< 0.8 2. patients with severe leg swelling (pitting edema of grade 3 or higher) or with pre-existing or post-operative heart failure that remains uncontrolled despite diuretic therapy. 3. patients with occlusive peripheral arterial disease (pad) or chronic venous insufficiency (ceap 2s), characterized by significant venous stasis, leg pain, varicose veins, or lymphadenopathy.

Eligibility criteria:
inclusion criteria: 1. all patients scheduled for elective coronary artery bypass grafting (cabg) surgery with saphenous vein harvesting from the leg at siriraj hospital. 2. patients aged 18 years and older undergoing cabg surgery with saphenous vein harvesting from the leg at siriraj hospital, who willingly consent to participate in the study. exclusion criteria: 1. patients with an ankle-brachial pressure index (abi) \< 0.8 2. patients with severe leg swelling (pitting edema of grade 3 or higher) or with pre-existing or post-operative heart failure that remains uncontrolled despite diuretic therapy. 3. patients with occlusive peripheral arterial disease (pad) or chronic venous insufficiency (ceap 2s), characterized by significant venous stasis, leg pain, varicose veins, or lymphadenopathy.

Keywords: compression bandages compression therapy customized pressure-guided elastic bandages cabg coronary arterial bypass graft
self screening tool for crohn's perianal fistula

Conditions: Crohn Disease

Summary: this study aims to develop a self-screening tool for crohn's perianal fistula.


Eligibility criteria:
inclusion criteria: * crohn's disease exclusion criteria: -
locally delivered 1% metformin gel in the treatment of intrabony defects in chronic periodontitis

Conditions: Intrabony Defects in Chronic Periodontitis

Summary: this study was designed as a randomized, controlled clinical trial to evaluate the efficacy of 1% mf gel as local drug delivery in adjunct to srp for the treatment of intrabony defects in chronic periodontitis in comparison with placebo gel.

background: metformin (mf) belonging to the class biguanide, is a first-line therapy for type 2 diabetes mellitus, and is one of the most commonly prescribed oral hypoglycemic drug worldwide. mf has shown to posses bone forming and bone sparring actions. the present study was designed to investigate effectiveness of mf, 1 % in an indigenously prepared biodegradable controlled-release gel as, as an adjunct to scaling and root planing (srp) in treatment of chronic periodontitis subjects with intrabony defects. materials and methods: sixty five subjects were categorized into two treatment groups: srp plus 1% mf and srp plus placebo. clinical parameters were recorded at baseline and at 3 and 6 months; they included plaque index (pi), modified sulcus bleeding index (msbi), probing depth (pd), and clinical attachment level (cal). at baseline and after 6 months, radiologic assessment of intrabony defect (ibd) fill was done using computer-aided software.

Eligibility criteria:
inclusion criteria: * systemically healthy subjects * sites with probing depth (pd) ≥5 mm * clinical attachment level (cal) ≥4 mm * vertical bone loss ≥3 mm on intraoral periapical radiographs with no history of periodontal therapy or use of antibiotics in the preceding 6 months were included exclusion criteria: * patients with known systemic disease * known or suspected allergy to the mf/ biguanide group * patients on systemic mf or other oral antidiabetic therapy * patients with aggressive periodontitis * patients with diabetes * use of tobacco in any form * alcoholism * immunocompromised patients * pregnant or lactating females
effect of two doses of coenzyme q10 on seminal fluid and semen antioxidant status

Conditions: Male Infertility

Summary: the study was conducted to assess the impact of two doses of coenzyme q10 on seminal fluid parameters and antioxidant status in infertile men.

the aim of this study was to assess the impact of two doses of coenzyme q10 on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.

Eligibility criteria:
inclusion criteria: * history of infertility of at least 12 months despite regular unprotected intercourse. oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (\<15 million/ml), progressive motility (\<32%), total motility (\<40%) and morphology (\<30% who criteria) as defined by who manual for semen analysis 2010 exclusion criteria: * azoospermia, * varicocele, * genital tract infection, * cryptorchidism, * testicular trauma or scrotal surgery, * endocrine disorder, * systemic illness, * smoking * the presence of female factor

Keywords: male infertility coenzyme q10 antioxidants