Kornimate/medical-research-clean huggingface dataset:
evaluation of the prognostic value of the suppression ratio evaluated by bis among patients admitted to the icu for cardiac arrest

Conditions: Cardiac Arrest

Summary: the aim of this study is to evaluate the prognostic value of the suppression ratio monitored by bispectral index for prediction of neurologic outcome after cardiac arrest. all patient admitted to our intensive care unit after a cardiac arrest are included. the results of the suppression ratio will be collected in the 6 first hours of admission. we will evaluate the link between suppression ratio and cerebral performance category score collected at three months.


Eligibility criteria:
inclusion criteria: * adult * cardiac arrest admitted to the icu exclusion criteria: - pregnancy
angelman syndrome video assessment (asva) source material study

Conditions: Angelman Syndrome

Summary: this is a longitudinal, observational, nonrandomized, fully remote study enrolling approximately 55 participant-caregiver dyads. the study includes no treatments or interventions, and participants will not be asked to change their current treatments. the objective of this study is to gather sufficient source material videos to develop a scoring system for asva and to perform preliminary validation of that scoring system.


Eligibility criteria:
* caregiver reports that the individual with as has a laboratory-confirmed diagnosis of angelman syndrome * individual with as is at least 1 year old * caregiver is willing and able to provide informed consent for themselves and oversee study participation * caregiver or legal guardian is willing to provide informed consent on behalf of the individual with as * caregiver is comfortable reading and speaking in english * caregiver has access to a smartphone or tablet that is compatible with the study app or caregiver has internet access and is willing to use a wi-fi only device to record and upload videos nt-caregiver dyads will be eligible for inclusion if the: * neurotypical individual is between 1 and 8 years of age * caregiver is willing and able to provide informed consent and oversee study participation and nt individual is willing and able to provide assent, as applicable * caregiver is comfortable reading and speaking in english * caregiver has access to a smartphone or tablet that is compatible with the study app or caregiver has internet access and is willing to use a wi-fi only device to record and upload videos participant-caregiver dyads will be excluded from the study only if they do not meet the inclusion criteria above.

Keywords: angelman syndrome
impact of a curriculum about professionalism on stress response during a critical situation

Conditions: Professional Burnout; Professional Stress; Anesthesia; Medical Education; High Fidelity Simulation; Anxiety State

Summary: the purpose of this study is to evaluate the impact of a curriculum about professionalism on stress response during a critical situation in anesthesiology residents. residents in anesthesiology will complete a training program on professionalism during their first postgraduate year. they will go through a standardized simulated scenario where they have to manage an intra-hospital cardiorespiratory arrest and then meet the patient's family. stress response will be assessed and compared to a control group that did not receive the training program.


Eligibility criteria:
inclusion criteria: * residents in anesthesiology (postgraduate year 1) * voluntary exclusion criteria: * /

Keywords: cardiopulmonary arrest family patient meeting
mesh hernioplasty of strangulated hernias with intestinal resection

Conditions: Strangulated Hernia

Summary: primary suture repair increases the risk for recurrence, the fact of benefit of mesh repair in elective situations is documented, and many studies have reported beneficial outcomes of mesh hernioplasty in emergency situations. still there is controversy of using such grafts in presence of intestinal resection.

patients with acutely incarcerated hernias (with small intestine contents) who underwent polypropylene mesh hernioplasty were included in this prospective study from june 2005 through jan. 2011, patients were categorized into 2 groups who required intestinal resection anastomosis (group i)or not (group ii).

Eligibility criteria:
inclusion criteria: * strangulated hernias exclusion criteria: * above 75, under 18 * recurrent hernia * peritonitis * pure omentum contents asa above 3

Keywords: infection prosthesis recurrence strangulation
clinical study to validate the use of a new point of care troponin i test

Conditions: Acute Coronary Syndrome

Summary: this trial is designed as a prospective, multi-center, observational study of "all-comers" eligible adult subjects presenting to participating emergency departments with symptoms suggestive of acute coronary syndrome (acs)

this trial is designed as a prospective, multi-center, observational study of "all-comers" eligible adult subjects presenting to participating emergency departments (eds) with symptoms suggestive of acs and/or myocardial ischemia. subjects presenting with symptoms suggestive of acs will be screened and approached for consent for study enrollment by trained personnel. after obtaining written informed consent, subjects will have up to 4 blood samples collected for ctni testing using the meritas troponin i test and meritas point-of-care (poc) analyzer. blood draws and testing will occur at 4 intervals over 24 hours.

Eligibility criteria:
inclusion criteria: 1. the informed consent must be signed by the subject, or the subject's legal authorized representative. 2. 21 years of age or greater at the time of enrollment 3. subjects presenting to the ed with any symptoms suggestive of acs and/or myocardial ischemia, such as but not limited to: subjects currently having chest pain, pressure or a burning sensation across the precordium and epigastrium, pain that radiates to neck, shoulder, jaw, back, upper abdomen and either arm. exclusion criteria: 1. informed consent form not signed 2. age \<21 years 3. known pregnancy -
a safety and efficacy study of abt-089 in children with attention-deficit/hyperactivity disorder (adhd)

Conditions: Attention-Deficit/Hyperactivity Disorder

Summary: the purpose of this study is to test if the investigational medication abt-089 is a safe and effective treatment for children with attention-deficit/hyperactivity disorder or adhd.


Eligibility criteria:
inclusion criteria: * have voluntarily signed an informed consent form * meet diagnostic criteria for attention-deficit/hyperactivity disorder (adhd) based on detailed evaluation and interview with parent(s) * first grade or higher in a school setting 3 days/week * subject is generally in good health based on medical history, physical examination, clinical lab tests, and ecg * subject weighs at least 37 pounds (17 kg) * female subjects of childbearing potential must have a negative urine pregnancy test at screening and baseline and agree to comply with applicable contraceptive requirements * subject and parents have been judged by the study doctor to be reliable to keep required appointments for clinic visits and all tests, including blood draws, and examinations exclusion criteria: * subject is not functioning at an age-appropriate level intellectually * subject has a current or past diagnosis of bipolar disorder, psychosis, autism, asperger's syndrome, or pervasive developmental disorder * current diagnosis of obsessive-compulsive disorder, eating disorder, anxiety disorder or depressive disorder requiring treatment of any kind * subject has a history of significant allergic reaction to any drug * subject requires ongoing treatment with any psychiatric medication * subject has a serious medical condition, seizure disorder (except febrile seizures as an infant), or history of substance abuse or dependence
a study to determine the efficacy and safety of finerenone on morbidity and mortality among hospitalized heart failure patients

Conditions: Heart Failure; Acute Heart Failure

Summary: finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (hf) and mildly reduced or preserved left ventricular ejection fraction.

this is an international, randomized, double-blind, placebo-controlled, event-driven trial of finerenone for the treatment hospitalized heart failure patients with mildly reduced or preserved ejection fraction.

Eligibility criteria:
inclusion criteria: * provide electronic or written informed consent, either personally or through a legally authorized representative * age ≥18 years * current hospitalization or recently discharged with the primary diagnosis of heart failure * heart failure signs and symptoms at the time of hospital admission * imaging evidence of mildly reduced or preserved left ventricular ejection fraction (ef) (40% or higher) * elevated n-terminal pro b-type natriuretic peptide (ntprobnp) ≥1000 pg/ml or b-type natriuretic peptide (bnp) ≥250 pg/ml for patients without atrial fibrillation (af); or elevated ntprobnp ≥2000 pg/ml or bnp ≥500 pg/ml for patients with af exclusion criteria: * treatment with a mineralocorticoid receptor antagonist (mra) * documented prior history of severe hyperkalemia in the setting of mra use * estimated glomerular filtration rate (egfr) \ 5.0 mmol/l at screening * acute myocardial infarction, coronary revascularization, valve replacement/repair, or implantation of a cardiac resynchronization therapy device within 30 days * hemodynamically significant (severe) uncorrected primary cardiac valvular disease * cardiomyopathy due to known acute inflammatory heart, infiltrative diseases, accumulation diseases, muscular dystrophies, cardiomyopathy with reversible causes, known hypertrophic obstructive cardiomyopathy, complex congenital heart disease, or known pericardial constriction * probable alternative cause of participant's heart failure symptoms * concomitant systemic therapy with potent cytochrome p450 isoenzyme 3a4 (cyp3a4) inhibitors or moderate cyp3a4 inducers, or potent cyp3a4 inducers

Keywords: heart failure preserved ejection fraction mildly reduced ejection fraction hospitalized
hypercoagulability after breast cancer surgery

Conditions: Breast Cancer; Blood Coagulation Disorders

Summary: the risk of deep venous thrombosis after radical breast surgery is known. the objective of this study is to explore hypercoagulability after radical breast cancer surgery by studying several factors for haemostasis before, during and after surgery. ultrasound doppler examination is realised between 24 and 72 hours post-operatively. hypercoagulability is defined by a significant increasing level of thrombin-antithrombin, d-dimer and the endogen thrombin potential.


Eligibility criteria:
inclusion criteria: * breast cancer * mastectomy exclusion criteria: * thrombophilia * anticoagulant treatment

Keywords: hypercoagulability plasma coagulation parameters breast cancer
exercise program based on motor learning and forward head posture correction

Conditions: Musculoskeletal Abnormalities; Deformity

Summary: the aim of this study is to investigate the efficiency of an exercise program based on principles of motor learning in correction of forward head position (fhp) in asymptomatic patients.

epidemiological studies have shown that bad posture and poor body control occurs at puberty, with forward head posture (fhp) and rounded shoulders being the most common biomechanical deviations in sagittal plane. the fhp is defined as an anterior displacement of the head with hyperextension of the cervical spine and this is associated with a reduction in the length of the upper portion of the trapezius, posterior portion of the cervical extensor muscles, the sternocleidomastoid and the levator scapulae. fhp can be evaluated by measuring craniovertebral angle (cva) which is defined as the angle between a horizontal line passing through c7 and a line extending from the tragus of the ear to c7. cva, smaller than 50 degrees, constitute a criterion of abnormal posture of cervical spine, suggesting fhp. people with fhp present incomplete balance control, thereby affecting the position of the center of gravity and motor control of the body. the establishment of altered motor control strategies could lead to balance disorders, neck muscle imbalances, chronic neck pain and even respiratory dysfunction. despite the efforts of researchers to create effective treatment programs based on strength training and stretching exercises, positive long-term results have been a problem in fhp correction. for this reason, re-education of posture and body alignment, through exercise programs based on motor learning, with cognitive elements (attention, motivation, feedback, reasoning), could be proved a more effective therapeutic strategy.

Eligibility criteria:
inclusion criteria: * students at technological educational institute of sterea ellada, * aged 18-26 years old * males and females * craniocervical angle \< 50 degrees (statical forward head posture in standing position) exclusion criteria: * injury or surgery in cervical spine * accompanying neurologic, musculoskeletal or mental problems * any medical administration * intense continuous or intermittent neck pain * bmi \>25 * participation in any rehabilitation or physiotherapy sessions considering neck dysfunction the last 6 months * change in physical activities during the research period of 6 weeks

Keywords: neck motor control motor learning
applying artificial intelligence to optimize early-stage hepatocellular carcinoma treatment based on multi-modal image

Conditions: Hepatocellular Carcinoma

Summary: this study intends to establish two prognostic models based on contrast-enhanced ultrasound (ceus) and dynamic enhanced magnetic resonance (de-mri) multimodal images: prognostic model of liver cancer patients after hepatectomy and prognostic model of liver cancer patients after radiofrequency ablation. combined with artificial intelligence imaging omics, traditional imaging omics and clinical information, to predict and compare the prognosis of two different treatment methods for early liver cancer, so as to realize the individual selection of treatment methods for early liver cancer patients


Eligibility criteria:
inclusion criteria: * primary single hepatocellular carcinoma confirmed by histology or cytology, with a maximum diameter ≤5.0 cm; * good liver function, child-pugh grade a; * no serious dysfunction of heart, lung, kidney and other important organs ④ liver resection or radiofrequency ablation was performed in our hospital, and the study protocol and follow-up procedure were followed. exclusion criteria: * patients who cannot perform dce-mri examination due to metal implants in the body ② patients who had received other treatment before dce-mri or ceus; * invisible lesions, diffuse lesions or poor dce-mri/ceus image quality under ceus; ④ drug abuse, clinical or psychological or social factors that make informed consent or study implementation affected.
prevalence of periodontitis based upon principles presented by the 2017 classification: a hospital-based cross-sectional study on a sample of young egyptian dental patients

Conditions: Periodontitis

Summary: the study aims at determining the prevalence of periodontitis based upon principles presented by the 2017 classification: a hospital-based cross-sectional study on a sample of young egyptian dental patients


Eligibility criteria:
inclusion criteria: 1. patients whose age from 12 to 39 years old . 2. patient consulting in the outpatient clinic 3. provide informed consent. exclusion criteria: 1. patients having problem in opening their mouth or undergoing inter maxillary fixation where oral examination will not be possible. 2. patients diagnosed with psychiatric problems or intoxicated with alcohol or drugs
retrospective safety survey in patients included in nv1fgf clinical trials

Conditions: Peripheral Arterial Occlusive Disease

Summary: the objective of this study is to collect retrospectively long term safety data in patients who have participated in the previous phase i-ii trials conducted with the compound.


Eligibility criteria:
inclusion criteria: * patient randomized, treated and alive at the end of the phase i-ii study participation, irrespective of their treatment group, * who signed the talisman survey informed consent (or for deceased patients, the informed consent was signed the legal representative/family member as per national regulations - except in countries where ethics committee approval only is required for retrospective data collection). the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
local steroid treatment for idiopathic granulomatous mastitis (lstigm)

Conditions: Granulomatous Mastitis

Summary: this study evaluates the clinical response rate of local steroids in the treatment of idiopathic granulomatous mastitis in female adults. half of the participants will receive local injection combined with topical steroids and the other half will receive topical steroids mono-therapy.

idiopathic granulomatous mastitis (igm) is a rare benign inflammatory breast disease of unknown etiology.clinical presentation of igm can be variable. some findings may be confused with breast malignancy. although igm as a disease has been known for nearly four decades, no treatment consensus has been reached because of its rarity. surgical treatment, antibiotics, oral steroids, topical steroids, immunosuppression (methotrexate, mycophenolate mofetil) and close follow up have all been reported to be effective. currently,surgical treatment and systemic steroids treatment are most frequently employed. with the consideration of side effects of long term systemic (oral) steroid usage, topical steroids without systemic use were assessed and showed satisfactory curative effect. but there is no data concerning the use of local injection of steroids therapy on igm.the purpose of this study is to evaluate the effectiveness of steroids local injection on the basis of topical steroids for igm treatment.

Eligibility criteria:
inclusion criteria: * idiopathic granulomatous mastitis * require non-surgical treatment exclusion criteria: * breast carcinoma

Keywords: granulomatous mastitis local injection topical steroids
biologic assessment of satiety

Conditions: Obesity

Summary: subjective measures of satiety are correlated with biologic mechanisms of appetite control.


Eligibility criteria:
inclusion criteria: * medical history (interview) demonstrating good health * non-smoking * not taking steroid-based medications * not planning to or currently attempting to gain or lose weight * being willing to consent to study conditions * healthy adults ages 25-45 years * body mass index between 18-30 kg/m2. * university of north dakota students may participate but student status is not required. exclusion criteria: * diagnosed eating disorders * current or planned pregnancy * lactation * unmanaged hypertension (systolic \>160 mmhg or diastolic \> 100mmhg) and/or other cardiovascular, pulmonary, skeletal and metabolic diseases * taking medications known to affect appetite, body composition, weight, or food intake

Keywords: obesity satiety body weight management
the acute effect of aerobic exercise on sleep in patients with depression

Conditions: Depression; Sleep; Sleep Disorder; Sleep Disturbance; Sleep Fragmentation; Sleep Initiation and Maintenance Disorders; Insomnia; Insomnia, Psychophysiological; Insomnia Due to Other Mental Disorder; Insomnia Related to Another Mental Condition

Summary: the aim of this trial is to investigate the effects of a single bout of aerobic exercise on sleep in patients with depression.

primary objective: the primary objective of this study is to evaluate whether a single bout of aerobic exercise improves sleep efficiency more than a control condition in patients with depression. secondary objectives: secondary objectives are to assess the effects of a single bout of aerobic exercise on 1) sleep continuity, 2) sleep architecture, 3) pre-sleep arousal, 4) subjective sleep quality, 5) daytime sleepiness, 6) nocturnal blood pressure, 7) heart rate variability, and 8) the frequency and severity of adverse events. design: this will be a two-arm parallel group, randomized, outcome assessor blinded, controlled, superiority trial. according to sample size calculation a total of 92 patients will be randomized using minimization. the trial will take place in the first five days of the patients' psychosomatic in-patient rehabilitation in the clinic oberwaid, st.gallen, switzerland. the study visits are scheduled is as follows: day 0-2: screening, inclusion, and graded exercise test to determine exercise intensity of intervention day 3: questionnaires for background information night 1 (day 3-4): baseline polysomnography and sleep related questionnaires day 4: randomized allocation (control or exercise condition) and performing corresponding intervention night 2 (day 4-5): follow-up polysomnography and sleep related questionnaires day 5: daytime sleepiness questionnaire

Eligibility criteria:
inclusion criteria: * inpatient psychosomatic rehabilitation in the clinic oberwaid, st.gallen, switzerland * age: ≥18 and ≤65 years old * primary diagnosis of depression (f32, f33) without psychotic episode according to international statistical classification of diseases, 10th edition exclusion criteria: * regular use of hypnotic agents (patients were included if no hypnotic agents were taken 2 weeks prior to study participation) * factors precluding exercise testing or training * use of beta-blockers (with the exception of carvedilol \& nebivolol) * use of opioids * history of epilepsy * restless legs syndrome defined by ≥7 points on the restless legs syndrome screening questionnaire (rlssq) * moderate or severe sleep apnea defined by an oxygen desaturation index (odi) ≥15 in the first polysomnography. * morbid adiposity with bmi \>40

Keywords: exercise sleep depression heart rate variability blood pressure randomized controlled trial polysomnography
analyzing olfactory dysfunction mechanisms in covid-19

Conditions: SARS-CoV-2

Summary: we aim to understand the mechanism of olfactory dysfunction in covid-19.

in december 2019, a new coronavirus causing severe acute respiratory syndrome was described in wuhan, china. this virus, later named severe acute respiratory syndrome coronavirus 2 (sars-cov-2), spread worldwide and has been designated a pandemic by the world health organization. by the beginning of march 2020, several ear, nose, throat societies raised awareness of a frequent association between coronavirus disease 2019 (covid-19) and smell disorders. in the present study, the investigators wish to begin to understand the pathogenesis of olfactory dysfunction in covid-19.

Eligibility criteria:
inclusion criteria: - deceased hospitalised patients, tested positive or negative for sars-cov-2 for patient or control group respectively exclusion criteria: * none

Keywords: hyposmia anosmia olfactory dysfunction covid-19 sars-cov-2