Kornimate/medical-research-clean huggingface dataset:
comparison of techniques between concave distraction and convex resection in the treatment of congenital cervical scoliosis

Conditions: Congenital Scoliosis Due to Bony Malformation; Cervical Scoliosis

Summary: to treat congenital cervical scoliosis, previous literature introduced surgical technique, like hemivertebra resection by anterior and posterior approach. although this technique is effective, it has a lot of disadvantages. so investigators introduce another surgical technique.

although hemivertebra resection technique can obtain satisfactory clinical outcome, it has its disadvantages. because of the presence of vertebral arteries, the procedure of cervical hemivertebra resection is not only difficult and risky, but also time and labor consuming. the operation is a great challenge to the skill, physical strength and energy of the surgical team. meanwhile, hemivertebra resection and compression on convex side may lead to iatrogenic foraminal stenosis and increase the incidence of nerve root palsy at the corresponding segment after surgery. the shortening of the convex side may further aggravate the patient's existing short neck deformity, which is not conducive to the recovery of patient's appearance. therefore, our department pioneer a new surgical technique to avoid hemivertebra resection in 2015, which is distraction and lateral opening on concave side. this technique extends the concave side through intervertebral space where the concave apex locates or adjacent intervertebral space to achieve the purpose of scoliosis correction. the avoidance of hemivertebra resection significantly reduces the difficulty and risk of the surgery. this procedure tries to make up for the patient's congenital anatomical deficiency and lengthen the concave side. although there is no need to expose vertebral artery, preoperative cta(computed tomography angiography) should be performed routinely to determine whether there is abnormality in vertebral artery and whether it will interfere with the distraction on concave side and the placement of prosthesis.

Eligibility criteria:
inclusion criteria: * the presence of torticollis caused by congenital cervical scoliosis (defined as a cobb angle of \>10°) * operation and follow-up were performed in our hospital exclusion criteria: * patients with other causes of torticollis appearance, such as muscular torticollis, ocular torticollis, neurogenic torticollis, etc. * patients with other spinal deformity or disease, such as cervical kyphosis or kyphoscoliosis, congenital deformity of middle and lower thoracic vertebra, lumbar vertebra, ankylosing spondylitis, severe ossification of cervical posterior longitudinal ligament, etc. * cervical infectious diseases, cervical primary or metastatic tumor * have a history of spinal trauma or surgery * imaging data are incomplete or of poor quality.

Keywords: congenital cervical scoliosis hemivertebra resection distraction and lateral opening spinal fusion
the effectiveness of group-delivered guided written exposure therapy for cptsd symptoms among adolescents : a multi-centered randomized controlled trail

Conditions: CPTSD, Compelx Post-traumatic Stress Disorder

Summary: this study aims to examine the effectiveness of group-delivered guided written exposure therapy for complex post-traumatic stress disorder (gwe-c) among chinese adolescents through a randomized controlled trial. a total of 120 participants will be recruited, with 60 randomized to the gwe-c group and 60 randomized to the supportive therapy (st) group. the gwe-c intervention will consist of 7 to 10 group sessions. the primary outcome, assessed by the international trauma questionnaire (itq), will be measured at baseline, post-treatment, 1-month follow-up, and 3-month follow-up.


Eligibility criteria:
inclusion criteria: * aged between 10 and 18 years; * meet the diagnostic criteria or subclinical criteria for complex ptsd (c-ptsd) , defined as missing either one symptom from the ptsd clusters, or the dso cluster; * possess sufficient literacy and language skills to complete writing-based tasks; * be able to understand the study procedures and complete the required assessments; * provide written informed consent, with consent also obtained from their legal guardians. exclusion criteria: * presence of a severe psychiatric disorder or neurodevelopmental disorder, such as schizophrenia, bipolar i disorder, autism spectrum disorder, intellectual disability, or other severe psychiatric conditions that would interfere with study participation; * presence of a severe physical illness that would impair the ability to engage in the intervention; * suicidal ideation within the past six months; * ongoing exposure to traumatic events; * currently receiving other trauma-focused psychological treatments.

Keywords: adolescents cptsd randomized controlled trial
efficacy and safety study of apixaban for extended treatment of deep vein thrombosis or pulmonary embolism

Conditions: Venous Thrombosis

Summary: the purpose is to evaluate the effects of an investigational blood thinner, apixaban, in preventing venous thromboembolic (vte) recurrence or death in patients who have completed their intended treatment for deep vein thrombosis (dvt) or pulmonary embolism (pe)


Eligibility criteria:
inclusion criteria: * men and women ≥ 18 years of age; * clinical diagnosis of deep vein thrombosis (dvt) or pulmonary embolism (pe); * anticoagulant treatment completed * no recurrence of venous thromboembolism (vte) exclusion criteria: * subjects with indications for long-term treatment with a vitamin k antagonist * active bleeding or high risk for serious bleeding * short life expectancy * uncontrolled high blood pressure * impaired kidney or liver function
study to evaluate automated intensity management in patients undergoing a bsc scs temporary trial

Conditions: Chronic Pain; Intractable Pain; Low Back Pain; Pain, Neuropathic; Pain, Back

Summary: the purpose of the study is to assess the feasibility of using information extracted from physiologic signals to automatically adjust stimulation in patients undergoing spinal cord stimulation (scs).


Eligibility criteria:
key inclusion criteria: * study candidate is undergoing a temporary scs trial of commercially approved bsc neurostimulator system, per local directions for use (dfu). * subject signed a valid, ec/irb-approved informed consent form. * age 18 or above, or above legal age and willing and capable of giving informed consent specific to national law when written informed consent is obtained. * in the clinician best judgment, subject is able to distinguishably describe quality and location of sensation and pain. key exclusion criteria: * subject meets any contraindication in bsc neurostimulation system local dfu. * investigator-suspected gross lead migration during the scs trial period which may preclude the study candidate from receiving adequate scs therapy. * subject is currently diagnosed with cognitive impairment, or exhibits any characteristic, that in the clinician's best judgement would limit study candidate's ability to assess and report sensation information. * subject is currently diagnosed with a physical impairment, or exhibits a condition that would limit study candidate's ability to complete study assessments.
overnight pain treatment investigating opioids vs. nonopioids

Conditions: Abortion Second Trimester

Summary: the purpose of this study is to compare maximum pain scores between patients seeking induced abortion and requiring cervical preparation with osmotic dilators. patients will be randomized to receive prescription for ibuprofen alone or to receive prescription for ibuprofen + oxycodone for overnight pain management after cervical preparation with osmotic dilators. data collected in-person and through a text-messaging platform.


Eligibility criteria:
inclusion criteria: * english-speaking women * 18 years or older * access to cell phone with text-messaging capability/data * receiving cervical preparation for induced abortion * able to complete baseline survey on smartphone/tablet at screening visit exclusion criteria: * history of opioid or alcohol abuse * contraindications or allergy to ibuprofen * contraindications or allergy opioid medications * seeking uterine evacuation for premature preterm rupture of membranes or advanced - cervical dilation or intrauterine fetal demise
canadian eye injury registry

Conditions: Eye Injuries

Summary: the purpose of this study is to establish an eye injury registry to assess the mechanisms and outcomes of significant eye injuries occurring in canada. the epidemiologic data will determine where public health strategies should be directed to prevent future eye injuries.

currently there is no established database or recording system of eye injuries occurring in canada. estimates place the figure at approximately 100000 significant eye injuries occurring in our country every year. this represents a large public health and long-term disability challenge. lost productivity of working-age individuals with vision loss amounts to $4.4 billion annually in canada, part of which is due to eye injury. by recording the types, locations, and outcomes of significant eye injuries, it is hoped improved public health strategies may be established to prevent further ones. the need for such a database has been recognized by the ivey eye institute, the canadian national institute for the blind (cnib) and the canadian ophthalmological society (cos). the united states eye injury registry (useir) has been in existence for greater than 20 years. through their database they have recorded thousands of eye injuries which has led to public health interventions through their various ocular societies. they have also established a standardized reporting system and ocular trauma score which has improved diagnosis and prognosis of eye injuries. this system has been used in many countries as a standardized reporting scheme for eye injuries. it is hoped that through a pilot recording system established in london a framework for a national reporting system will develop. the objective is to use the standardized reporting system of the useir to report canadian eye injuries. the time frame for outcome measures will be 6 months. the patients will be followed along for this amount of time to assess there visual outcomes. no further follow up after 6 months will be undertaken for the purpose of the registry. the hypothesis is that by recording the type and outcome of eye injuries, a better understanding of mechanisms and location of these injuries in canada will occur. subsequent public health interventions can then be made in conjunction with the cnib and cos to improve eye health in canada.

Eligibility criteria:
inclusion criteria: * any patient who experiences an acute eye injury that has or has the potential to compromise the integrity of the eye. these are serious eye injuries resulting in permanent and significant (i.e. measurable or observable on routine eye examination) structural or functional change to the eye. separate reports are to be filed for each eye involved in bilateral injuries. exclusion criteria: * based on the standard of the united states eye injury registry * mild ocular contusions * subconjunctival hemorrhage * superficial abrasions by themselves usually would not meet the criterion of serious and/or reportable injuries. * the exclusion of these injuries will depend on the clinical judgement of the reporting physician.

Keywords: canadian eye injury registry
phase 1 study of sgi-110 in patients with acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: to evaluate the tolerability and pharmacokinetics of sgi-110 when administered subcutaneously to japanese patients with acute myeloid leukemia (aml).


Eligibility criteria:
inclusion criteria: * male or female patients with a diagnosis of aml (who classification 2008). * patients, 20 years of age or older, who are unresponsive to standard chemotherapy or have relapsed following standard chemotherapy * patients, 65 years of age or older, who are not eligible for standard intensive chemotherapy * patients with ecog performance status (ps) of 0 to 2 * patients with adequate organ function * women of child-bearing potential must not be pregnant or breast feeding (pregnancy test will be performed at screening). women of child bearing potential and all men with female partners of child bearing potential must practice two medically acceptable methods of birth control and must not become pregnant or father a child while receiving treatment with sgi-110 and for 3 months following last dosing. * patients who have undergone prior allogeneic hematopoietic stem cell transplantation must have no evidence of active graft-versus host disease (gvhd) and must be off immunosuppressive therapy by ≥2 weeks prior to imp administration. exclusion criteria: * patients with acute promyelocytic leukemia accompanied by t(15;17)(q22;q12) or (pml/rara) karyotype abnormalities (include other variant types of apl) * patients with multiple cancers (except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer from which the subject has been disease free for at least 3 years) * subjects with life-threatening illnesses other than aml or mds, uncontrolled medical conditions or organ system dysfunction which, in the investigator's opinion, could compromise the subject's safety, or put the study outcomes at risk. * patients with poorly controlled arrhythmias, or any class 3 or 4 cardiac disease as defined by the new york heart association functional classification * patients with symptomatic central nervous system involvement.
validity and reliability of the map-hand scale in patients with carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome (CTS)

Summary: the primary aim of the study was to determine the validity and reliability of the "map-hand (measure of activity performance of the hand)" scale in patients with carpal tunnel syndrome. the secondary aim of the study was to evaluate the hand activity performance in patients with carpal tunnel syndrome.


Eligibility criteria:
inclusion criteria: 1. age 18 and above and able to read and write 2. diagnosed with mild or moderate unilateral cts according to electroneuromyography results at least 6 months ago 3. motor-sensory symptoms such as numbness and loss of strength in the hand for at least three months 4. volunteers with no history of diabetes, no medical treatment or injections, no surgery, and no cervical radiculopathy or polyneuropathy exclusion criteria: 1. those with trauma, deformity, fracture, muscle contracture and atrophy in the shoulder, forearm and hand 2. those who have received corticosteroid injections into the carpal tunnel area within the last three months and have been included in a physiotherapy program 3. those who have cognitive problems

Keywords: carpal tunnel syndrome reliability validity
narrative intervention for long covid-19 (nico)

Conditions: Long COVID; Long Covid19

Summary: this t1 proof of concept trial is designed to test the narrative intervention for long covid-19 intervention.

people living with covid19 long haul syndrome frequently experience high symptom burden and problems performing basic activities of daily living. covid19 has impacted mental health not only for people directly affected by the pandemic, including people who are living with covid19 long haul syndrome, but also those affected indirectly, putting further strain on the mental health system, which was already under stress. understanding the experience of covid 19 long haul syndrome that can inform innovative and impactful ways to improve living with covid19. mental health providers are in high demand with an increase in burnout. one study reported 1/3 of mental health providers have experienced severe burnout since the onset of the pandemic. there are nursing staff shortages across the us, especially in rural areas. shortages also occur within social work staff globally. there is a need to design innovative, interdisciplinary, and less time-intensive interventions to help those living with chronic illness. more people living longer with different types of illnesses and staffing shortages make traditional talk therapy interventions more challenging to deliver to more people. this study has two specific aims: aim 1: establish the acceptability and feasibility of an asynchronous narrative intervention for people living with long haul covid19. aim 2: explore themes of illness narratives of people living with long haul covid19

Eligibility criteria:
inclusion criteria: * diagnosed with long covid * have access to email weekly * between the ages of 18-89 years old exclusion criteria: * conflicting research study
replication of the horizon pivotal fracture trial in healthcare claims data

Conditions: Osteoporosis

Summary: investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials. the investigators' goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies.

this is a non-randomized, non-interventional study that is part of the rct duplicate initiative (www.rctduplicate.org) of the brigham and women's hospital, harvard medical school. it is intended to replicate, as closely as is possible in healthcare insurance claims data, the trial listed below/above. although many features of the trial cannot be directly replicated in healthcare claims, key design features, including outcomes, exposures, and inclusion/exclusion criteria, were selected to proxy those features from the trial. randomization is also not replicable in healthcare claims data but was proxied through a statistical balancing of measured covariates according to standard practice. investigators assume that the rct provides the reference standard treatment effect estimate and that failure to replicate rct findings is indicative of the inadequacy of the healthcare claims data for replication for a range of possible reasons and does not provide information on the validity of the original rct finding.

Eligibility criteria:
criteria: please see https://drive.google.com/drive/folders/1wd618wrywyjeaxzfltcuk-vccnb6b-gv for full code and algorithm definitions. eligible cohort entry dates: zoledronic acid indication for treatment of postmenopausal women with osteoporosis was approved by fda on aug 20, 2007. * for ibm marketscan: aug 21, 2007 - december 31, 2018 (end of available data) * for optum cdm: aug 21, 2007 - mar 31, 2020 (end of available data) inclusion criteria: * postmenopausal women between the ages of 65 and 89 years * osteoporosis diagnosis exclusion criteria: * bisphosphonate users * previous use of: 1. any use of parathyroid hormone 2. use of anabolic steroids or growth hormone within 6 months before cohort entry date or 3. use of oral or intravenous systemic corticosteroids within 12 months of cohort entry date * serious disease that may limit life expectancy to less than 6 months * malignant neoplasm diagnosis within 12 months prior to the cohort entry date * conditions that influence bone metabolism * treatment and prevention of glucocorticoid-induced osteoporosis * treatment of paget's disease of bone * alcohol abuse/dependence or drug abuse/dependence or non-compliance * pregnancy * diagnosis and procedure for amputee of lower limb * use of zoledronic acid within 450 days prior to the cohort entry date * use of denosumab within 450 days prior to the cohort entry date * diagnosis of end-stage renal disease or diagnosis and procedure for kidney transplant * diagnosis of end-stage liver disease: cirrhosis, hepatic decompensation * blindness or compromised vision * use of abaloparatide within 450 days prior to the cohort entry date * use of romosozumab within 450 days prior to the cohort entry date
remote exercise for learning anger and excitation management

Conditions: Anger; Stress Disorders, Post-Traumatic

Summary: the immediate objective of this project was to demonstrate the feasibility of remote exercises for learning anger and excitation management (relax). the application is a remote, technology- enabled, anger treatment and management system based on current evidence-based cbt interventions. the project's objective was to show that relax (1) enables the practice of anger management strategies remotely through mobile phone interfaces; (2) integrates with evidence-based treatments through the implementation of an existing cbt anger management course; (3) provides information, direction, and feedback through physiological sensors and signal analysis; and (4) supports communication and direction by the therapist through a web-based therapist interface.

this project conducted a cognitive behavioral therapy (cbt) anger management treatment groups with a veteran population using the relax application, collected weekly feedback from participants, and collaborate with the sponsor to document initial efficacy, feasibility, and safety of the relax system. outcome domains included: 1) clinical outcomes (symptom severity, social functioning); 2) process outcomes (perception of treatment, satisfaction, group therapy alliance, treatment compliance, and attrition and treatment credibility); and (3) technical feasibility of the relax application. study clinicians were 1) trained to conduct baseline and follow-up assessments 2) trained to conduct the standardized anger management therapy (amt) protocol at acceptable levels of adherence and competence and 3) trained how to use the technology and how to respond to technical difficulties. study clinicians tested the feasibility of the relax application and showed that it can be integrated with cbt anger management therapies and support therapist communication through the technology.

Eligibility criteria:
inclusion criteria: * a score of 20 or higher on the 10-item trait scale of the staxi * participants taking psychoactive medications have to have a stable regimen for at least 45 days prior to study entry * participants must be able to read, understand, and sign the consents themselves and be willing and able to comply with all study related procedures exclusion criteria: * active psychotic symptoms/disorder as determined by the structured clinical interview (scid) for diagnostic and statistical manual of mental disorders(dsm) * active homicidal or suicidal ideation as determined by the scid * any significant cognitive impairment or history of organic mental disorder as determined by the scid * active (current) substance dependence as determined by the scid (lifetime substance dependence or substance abuse not excluded) * unwillingness to refrain from substance abuse during treatment * female veterans * vulnerable persons such as those described in the section ethical considerations and regulatory issues, vulnerable population

Keywords: technology mobile anger management anger ptsd veterans