Kornimate/medical-research-clean huggingface dataset:
low and high frequency repetitive transcranial magnetic stimulation (rtms) in the treatment of resistant auditory hallucination in schizophrenia

Conditions: Schizophrenia

Summary: auditory hallucinations (ah) are experienced by 50 to 70% of subjects with schizophrenia. almost a quarter of patients are medication resistant to such symptoms. the application of rtms at low frequency in the left temporoparietal cortex reduces ah. a pilot study reported successful treatment of ah with high frequency rtms. rtms (20hz) should be a shorter and an easier treatment for out-patients with schizophrenia compared to low stimulation treatment.

90 schizophrenia patients diagnostic and statistical manual of mental disorders, 4th edition, text revision (dsm iv-tr) criteria with persistent auditory hallucinations (ah) resistant to antipsychotic treatments will be recruited. a double blind sham-controlled randomized parallel study comparing three groups treated 10 session in 5 days with high frequency (20 hz), low frequency (1hz) and sham-controlled condition rtms. they will be followed 3 month and evaluated using auditive hallucination rating scale (ahrs), scale for the assessment of positive symptoms scores (saps), scale for the assessment of negative symptoms scores (sans) and positive and negative symptom scale (panss) global score and global assessment of functioning (gaf) score.

Eligibility criteria:
inclusion criteria: * patients with schizophrenia dsm iv-tr criteria and persistent ah resistant to antipsychotic treatments. exclusion criteria: * left handed patients lateralizes * rtms contraindications

Keywords: rtms schizophrenia high frequency rtms low frequency rtms ahrs saps sans panss gaf uku
nevus doctor clinical decision support

Conditions: Nevus; Melanoma

Summary: the "nevus doctor" is a dermatoscopy based computer decision support tool to assist general practitioners (gps) in the classification of pigmented skin lesions (psls). the aim of the program "nevus doctor" is to help gps increase their diagnostic accuracy, in particular regarding the selection of suspicious psls that need biopsy or referral to specialist health care for further assessment. the aim of this study is to investigate the diagnostic performance of the decision support tool in a primary care setting in norway. we hypothesize that the diagnostic accuracy of the computer program "nevus doctor" is better than the performance of the gps.

in the trial gps examine patients who attend a primary health care center. a given psl is first assessed clinically by the gp and afterwards photographed. a clinical photograph as well as a dermatoscopic photograph is taken, the latter using a dermatoscope attached to the lens of the camera. the dermatoscopic image is then processed by the computer program. the performance of "nevus doctor" is compared with the gps' assessment. a dermatologist reviews all cases based on the clinical and dermatoscopic photographs and this assessment serves as the reference standard.

Eligibility criteria:
inclusion criteria: * pigmented skin lesion exclusion criteria: -

Keywords: computer-assisted diagnosis general practice dermatoscopy melanoma nevus
zoledronic acid in the management of patients with asymptomatic/early stage multiple myeloma

Conditions: Multiple Myeloma

Summary: evidence for the beneficial effects of bisphosphonates on bone resorption in multiple myeloma has been reported extensively, showing reductions in skeletal events and improvement of several biochemical variables in bone resorption. zoledronic acid (zometa®, cgp42446) is the most potent clinically available bisphosphonates, with the largest therapeutic ratio between the desired inhibition of calcium resorption and the unwanted inhibition of mineralization in vitro of all the bisphosphonates. this trial will investigate the efficacy of zoledronic acid in preventing skeletal events in patients with asymptomatic/early stage multiple myeloma

outline: this is a multi-center study. * patients will be randomly assigned by study number to receive 4mg of zoledronic acid every three months or to be observed. performance status: ecog performance status 0-3 (kps 30 - 100) life expectancy: 12 months hematopoietic: * hb \>10 g/dl within 14 days prior to registration hepatic: * not specified renal: * serum creatinine \< 2 mg/dl within 14 days prior to registration cardiovascular: * not specified pulmonary: * not specified

Eligibility criteria:
inclusion criteria: * diagnosis of asymptomatic multiple myeloma as defined by the criteria below: * presence of bone marrow clonal plasma cells (more than 10%) * presence of an m-protein in serum and/or urine (no concentration specified) * serum calcium \< 12 mg/dl within 14 days prior to registration. less than 3 lytic lesions, no pathologic fractures and no osteopenia noted on skeletal survey * no symptoms of hyperviscosity, amyloidosis or recurrent infection * bone mineral density with a t score higher than -2.0 standard deviation (not have osteoporosis) within 28 days prior to registration * negative pregnancy test exclusion criteria: * no previous treatment with bisphosphonates * no disorders of the parathyroid or thyroid glands * no current breastfeeding * no prior malignancy is allowed except for adequately treated in situ cervical cancer, gleason \< grade 7 prostate cancers

Keywords: multiple myeloma bisphosphonates
aneurysmal subarachnoid hemorrhage: red blood cell transfusion and outcome

Conditions: Subarachnoid Hemorrhage

Summary: the purpose of this study is to determine the feasibility of conducting a large trial examining the effect on clinical outcome of a liberal red blood cell (rbc) transfusion strategy compared to a restrictive strategy (usual care) in patients with aneurysmal subarachnoid hemorrhage (sah).


Eligibility criteria:
inclusion criteria: 1. age ≥18 years old at time of presentation 2. first ever episode aneurysmal sah 3. confirmed aneurysmal sah diagnosis: as confirmed by treating neurosurgeon or neuro-interventionalist and supported by blood in subarachnoid space (demonstrated on cranial imaging or cerebrospinal fluid positive for xanthochromia) that is the result of a ruptured saccular aneurysm (confirmed by cranial imaging - cranial topography or magnetic resonance imaging angiography or catheter angiogram) 4. incident hemoglobin ≤100g/l within 14 days following sah (defined by first day of hospital presentation) exclusion criteria: 1. physician and or family decision to withdraw/withhold critical care at time of enrolment 2. active bleeding with hemodynamic instability at time of enrolment 3. patients with contra-indication or known objection to blood transfusions 4. sah due to causes other than saccular aneurysm rupture including mycotic, traumatic and dissecting aneurysms, and aneurysms associated with arteriovenous malformations.

Keywords: blood transfusion
evaluation of helmet technology and head impact exposure

Conditions: MTBI - Mild Traumatic Brain Injury; Concussion, Mild

Summary: the purpose of the study is to monitor longitudinal changes in brain structure and function between the preseason and postseason, in a population of football playing athletes grouped by helmet make and model. secondly, the purpose is to determine the protection of the helmet make and model relative to amount and magnitude of sustained head impacts.

sports-related traumatic brain injury (stbi) is common in competitive sports and recreational activities, with 1.6 to 3.8 million reported annually in the u.s. children, adolescents and young adults are at the highest risk for sustaining mild tbi. there is scarce high-level prospective, objective evidence indicating that any recent helmet design can prevent stbi. while helmets were developed for, and are effective in, preventing skull fractures and intracranial hematomas, it is unclear if they afford protection against forces inside the cranium. this study will investigate the relationship between potential changes in brain structure and function pre and post season compared to helmet make and model and head impact exposure in high school and college athletes playing a collision sport such as football. the use of helmets/headgear during such a high-risk sport will allow for collision measurement devices to be affixed to the athlete under the helmet and will not affect play or fit of equipment. by the nature of the sport selected, it is likely this study will primarily include males, however if any female meets inclusion criteria on the team selected, the participant will be included in this investigation. all participants will be outfitted with an accelerometer which will measure the magnitude of every impact to the head sustained by the athlete. effectiveness of the helmet model will be determined via differences in longitudinal brain imaging and functional testing following competitive football participation. a subset of athletes who report a diagnosed concussion will also receive additional brain neuroanatomical and neurophysiological testing within a week following the diagnosed concussive event. the investigators will also enroll a group of athletes involved in a non-contact sport (such as cross country) to act as controls.

Eligibility criteria:
inclusion criteria: * normal healthy volunteer * able to provide written consent * must be 13 years or older and a participant on a high school or collegiate team exclusion criteria: * unable to provide written consent * not medically cleared to participate on a high school or collegiate team
enhanced measurement-based care effectiveness for depression (embed) study

Conditions: Major Depressive Disorder

Summary: measurement-based care (mbc) is an evidence-based practice that incorporates routine outcome assessment using validated rating scales to guide collaborative clinical decision-making. although mbc results in improved outcomes for patients with major depressive disorder (mdd), there are barriers to its broad implementation in clinical settings. the use of "enhanced" mbc (embc), with mobile apps that allow patients to track outcomes and engage in self-management via wechat, may address some of these barriers. the investigators hypothesize that implementation with embc using wechat will be superior to standard mbc implementation using paper-pencil assessments at the clinic, for both implementation and clinical outcomes.

the investigators present a trial protocol for a 2-arm cluster randomized controlled trial (rct) with a hybrid implementation-effectiveness design comparing standard mbc implementation versus embc implementation with 6-month follow up in 12 mental health centers in shanghai, china. the embc implementation uses a wechat mini-program that includes outcome tracking using brief questionnaires and self-management lessons supplemented with support by a lay coach via wechat.

Eligibility criteria:
inclusion criteria: 1. men or women aged 18-65 years; 2. participants were diagnosed of unipolar depressive disorder by the treating physician based on accepted diagnostic criteria (e.g., ccmd-3, dsm-iv, dsm-5, icd-10); 3. participants are expected to have a smartphone device available and be proficient in using a smartphone; 4. participants should have a junior high school education or above, have sufficient audio-visual skills, be able to fully understand the research content and have the legal ability to sign informed consent. exclusion criteria: 1. presence of obvious violent aggressive behavior or tendencies; 2. participants who are unstable during onset episodes and cannot cooperate in completing the study content; 3. serious suicidal tendencies; 4. inability to carry out effective verbal communication; 5. no smartphone; 6. other circumstances that prevented cooperation or completion of the study.

Keywords: measurement-based care scales assessment depression randomized cluster trial implementation mobile health wechat clinical trial mixed methods china
fidaxomicin versus vancomycin for the treatment of clostridium difficile-associated diarrhea (cdad) (mk-5119-018)

Conditions: Clostridium Infections; Diarrhea

Summary: this is a comparative study to investigate the safety and efficacy of fidaxomicin versus vancomycin in subjects with clostridium difficile-associated diarrhea (cdad).

the primary objective of this pivotal study is to investigate the safety and efficacy of fidaxomicin versus vancomycin in subjects with clostridium difficile-associated diarrhea (cdad). the cure rates at end of therapy and recurrence rates will be evaluated and compared.

Eligibility criteria:
inclusion criteria: * males/females with cdad * females must use adequate contraception * signed informed consent exclusion criteria: * life-threatening cdad * toxic megacolon * pregnant * concurrent use of diarrheal agents * participation in other trials

Keywords: cdad, clostridium difficile, diarrhea clostridium difficile-associated diarrhea
short term effects of anodal cerebellar vs anodal cerebral transcranial direct current stimulation in stroke patients

Conditions: Stroke

Summary: to compare the effect of anodal cerebellar transcranial direct current stimulation (tdcs) vs anodal cerebral tdcs on balance, mobility and cognition in stroke patients in stroke patients


Eligibility criteria:
inclusion criteria: * ability to give written consent. * able to walk unassisted * functional status allowing the participants to participate in the balance training. * score 6 or above on johns hopkins fall risk assessment tool exclusion criteria: * neurological diseases, such as parkinson, alzheimer * any history of psychological illnesses * receipt of electrotherapy that might affect the nervous system in the two weeks prior to the study * cerebellar disorders * use of any sedative medicines in the two days prior to the study * any symptoms of amnesia and depression; * memory disorders with scores below 21 on the mini mental status examination test * any signs of severe motor disorders in the lower extremity which cause any movement limitation or deformity * any signs of radiculopathy or root lumbar spinal cord involvement * any visual or auditory impairment, or vertigo reports * use of a heart rate regulator * any structural deformities in the lower extremities or the spine * any abnormalities in the vestibular system * history of recent fracture * inability to move without assistance

Keywords: anodal cerebral anodal cerebellar
acute clinical outcomes of hemorrhagic myocardial infarction

Conditions: Acute Myocardial Infarction

Summary: acute clinical outcomes 1. mortality 2. arrhythmia 3. readmission 4. cva 5. adhf


Eligibility criteria:
inclusion criteria: 1. 18-85 years of age 2. primary pci 3. post-pci cardiac biomarker labs
study of 3 doses of ard-0403 in testosterone deficient men

Conditions: Hypogonadism

Summary: the purpose of this study is to determine which dose, if any, results in testosterone levels within the normal range for men.


Eligibility criteria:
inclusion criteria: * testosterone deficiency * normal bmi exclusion criteria: * previous treatment with testosterone replacement therapy within 4 weeks * moderate-severe benign prostatic hypertrophy, or prostatic cancer * haematocrit \>50%
cytokine hemadsorption in covid 19 patients with bacterial sepsis

Conditions: INTERLEUKIN 6

Summary: in this retrospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in covid-19 icu patients with or without sepsis.


Eligibility criteria:
inclusion criteria: * covid-19 patients were the available data of laboratory diagnosis of covid-19 (a positive throat swab nucleic acid test or positive serum covid-19 specific antibody test), * patients with covid-19 induced sepsis was detection of bacterial agent in blood or tracheal culture exclusion criteria: * below 18 aged * those who did not undergo hemoperfusion
tactic- trans-disciplinary chronic disease continuity of care model

Conditions: Chronic Disease; Geriatrics

Summary: the overall aim of this study is to create a trans-disciplinary chronic disease continuity of care model with health information technology, utilizing mobile devices such as tablets, ipads and smartphones.

this study aims to explore if a trans-disciplinary chronic disease continuity of care model with integrated technology (mobile devices such as tablets, ipads and smartphones) to standard practice (patient-centered, coordinated care model without the integration of technology) will results in a reduction in 30-day readmission rate in adult patients.

Eligibility criteria:
inclusion criteria: * adult patients on a 43 bed medical surgical unit * adult patients on 44 bed geriatric unit exclusion criteria: * adult patients admitted and not diagnosed with chronic disease * patients who are transferred between intervention and non-intervention unit * patients who refuse * patients with delirium, dementia and altered mental status * patients who cannot read and write in any language * patients in the intervention group who cannot use mobile technology
an innovative approach to automated carbon dioxide angiography during endovascular abdominal aortic aneurysm repair

Conditions: Abdominal Aortic Aneurysm

Summary: the study aims to perform endovascular aortic repair procedures with co2-angiography using a standardized an operative protocol


Eligibility criteria:
inclusion criteria: * age \> 18 years * male, female * patients with indication for aaa * informed consent achievement exclusion criteria: * severe copd (chronic obstructive pulmonary disease) * known atrium- or ventricular septal defect with right-left-shunt * severe renal arteries atherosclerosis * ruptured aaa * current partecipation in other interventional studies

Keywords: endovascular aortic repair
study of mra in patients with rheumatoid arthritis (ra)

Conditions: Rheumatoid Arthritis

Summary: this is an open-label, extension, phase ii study to evaluate the long-term safety and efficacy of mra in patients with ra who were participated in study mra009jp.


Eligibility criteria:
inclusion criteria: * patients administered mra more than 2 times in preceding study, mra009jp, and evaluated the efficacy and the safety. * patients confirmed to have shown the safety in the preceding study. exclusion criteria: * patients with class iv steinbrocker functional activity at evaluation within 4 weeks before treatment with the study drug * patients who received any of the following treatments between the start of preceding study and the registration of this study. 1. plasma exchange therapy 2. surgical treatment (e.g., operation)
the impact on survival of neo-adjuvant transarterial chemoinfusion (tai) for patients with hepatocellular carcinoma and portal vein tumor thrombosis (pvtt) who underwent hepatectomy : a random, controlled, stage iii clinical trial.

Conditions: Hepatocellular Carcinoma

Summary: to compare the impact on survival of neo-adjuvant tai for patients with hcc and pvtt who underwent hepatectomy.


Eligibility criteria:
inclusion criteria: * older than 18 years old and younger than 75 years; * ecog ps≤1; * proven hepatocellular carcinoma according patological examination or easl/aasld diagnostic criteria; * not previous treated for tumor; * estimated tumor and tumor thrombosis could be removed en bloc in operation; * no distant metastasis; * the lab test could meet: neutrophil count≥2.0×109/l; hemoglobin≥100g/l; platelet count≥75×109/l; serum albumin≥35g/l; total bilirubin\<2-times upper limit of normal; alt\<3-times upper limit of normal; ast\<3-times upper limit of normal; serum creatine\<1.5-times upper limit of normal; pt≤upper limit of normal plus 4 seconds; inr≤2.2; * sign up consent; exclusion criteria: * cannot tolerate tai or surgery; * distant metastasis exits; * known history of other malignancy; * be allergic to related drugs; * underwent organ transplantation before; * be treated before (interferon included); * known history of hiv infection; * known history of drug or alcohol abuse; * have gi hemorrhage or cardiac/brain vascular events within 30 days; * pregnancy;
prognostic values of pet examination with 11 c-fe_cit with voxel-based analysis method in patients with sporadic parkonson's disease and parkinsonisms (prot.pd-diagn).

Conditions: Parkinson Disease

Summary: the role of pet for the in vivo study of the presynaptic dopaminergic system with 11c-fe-cit is universally recognized, and its use has also become routine in numerous nuclear medicine centers in europe. the indication for the examination is provided exclusively by the clinic in the presence of extrapyramidal signs in the suspicion of parkinson's disease (pd) or for the differential diagnosis of parkinsonisms. the existence of factors that influence the prognosis of patients with pd or parkinsonism associated with other degenerative diseases is known. given these premises, the possibility of identifying the disease in the early stages appears fundamental. for this purpose the following should be considered: 1. an automatic analysis method based on the measurement of radiotracer uptake at the level of individual voxels, following statistical parametric mapping procedures. 2. the analysis based on regions of interest (rois) positioned ad hoc by the operator which will give the value of the roi to reference region ratio. in particular, rois on the basal ganglia (caudate, putamen) towards cerebellum. both of these methods offer a quantitative measurement of the damage at the level of the structures involved that is absolutely better than the visual investigation of the distribution of radioactivity in the central nervous system. in this study the investigators want to compare results provided by methods 1 and 2 in the populations under examination to evaluate the data relating to the specificity and sensitivity of the test.


Eligibility criteria:
inclusion criteria: * diagnosed with initial pd or parkinsonism; * signature of informed consent. exclusion criteria: * patients \< 18 years
preoperative anxiety at oocyte retrieval

Conditions: Infertility, Female; Anesthesia Awareness; Anxiety State

Summary: this study evaluated the effects of preoperative anxiety and dosage of anesthesia on ivf success. half of participants according to the recorded beck's anxiety inventory (bai) score: a low-anxiety group, while the other half high-anxiety group.

anxiety is common among women hospitalized for oocyte retrieval. infertility is usually accompanied by psychological and behavioral changes and can result in preoperative anxiety. sometimes, preoperative anxiety can be serious. furthermore, in the absence of premedication for oocyte retrieval, severe degrees of anxiety may occur. anxiety effects the total consumption of analgesic and anesthetic drugs intraoperatively and has a negative impact on recovery from anesthesia. in addition, the negative effect of anesthetic agents used on fertilization and embryo quality during in vitro fertilization (ivf) has been discussed. however, the impact of any of them on fertilization and embryo quality has not been clearly determined to date. studies have reported different results regarding the negative effects of anesthetic agents on embryo development and fertilization.

Eligibility criteria:
inclusion criteria: * oocyte retrieval under sedation * 25 and 43 years of age * american society of anesthesiologists physical status i-ii exclusion criteria: * history of psychiatric illness * secondary infertility can be surgically corrected * not able to communicate well in the native language * those women who necessitated general anesthesia

Keywords: anxiety oocyte retrieval monitoring of brain function