Kornimate/medical-research-clean huggingface dataset:
the value of enhanced external counterpulsation on erectile dysfunction

Conditions: Erectile Dysfunction

Summary: the purpose of this study is to investigate the efficacy of enhanced external counterpulsation (eecp) in patients with erectile dysfunction

patients with erectile dysfunction will be randomized into two groups: eecp intervention or not. erectile function, hemodynamic parameters, vascular endothelial function will be measured and compared.

Eligibility criteria:
inclusion criteria: 1. men over 18 years old; 2. provide signed informed consent; 3. existence of erectile dysfunction 4. agree not to use any other erectile dysfunction treatment at least one month; exclusion criteria: 1. history of long drug abuse; 2. pelvic, spine, brain trauma or surgery; 3. endocrine, liver, lung, kidney disease, malignancies, hematological disorders; 4. abnormal urogenital status, such as small testicle (\<2cm), penile plaques;

Keywords: erectile dysfunction vascular endothelium counterpulsation, external
endocarditis registry of the university hospital of cologne (er-uhc)

Conditions: Infective Endocarditis

Summary: as recommended in the guidelines on the prevention, diagnosis, and treatment of infective endocarditis (ie) patients with ie should be evaluated and managed by a multispecialty team including an cardiologist, infectious disease specialist, and cardiac surgeon. our registry is a prospective, national registry of patients with ie. from january 2013 data from endocarditis board were prospectively recorded using standard definitions during the hospitalization. patient demographics, clinical, laboratory, and imaging data at the time of ie diagnosis, as well as treatment outcomes were entered into the er-uhc database.

the primary endpoint will be the 1 year all-cause mortality after treatment begins of ie. we will use 1 year all-cause mortality as the primary endpoint because it has been demonstrated that a period of at least 6 months is necessary to offset the early postoperative mortality related to valve surgery. we also looked at all-cause in-hospital mortality as a secondary endpoint.

Eligibility criteria:
inclusion criteria: * all patients with patients with definitive infective endocarditis exclusion criteria: * childs
utility of a mobile application for young women with breast cancer

Conditions: Breast Cancer; Cancer Distress

Summary: this study aims to evaluate the use of mobile technology as a communication tool among patients with breast cancer and measured its effect on patient-reported cancer-related distress, specifically focusing on young women as they often face unique challenges.

this is a prospective, randomized, two stage study. the target population is adult females ≥ 18 and ≤ 45 years of age with breast cancer with a national comprehensive cancer network (nccn) distress thermometer score of distress score ≥ 4. the study will be conducted at atrium health wake forest baptist comprehensive cancer center (ahwfbccc). the hypothesis is that the social connectivity via the mighty pro application, as well as the educational components available in the application, will decrease patients' cancer-related distress. this study aims to evaluate the feasibility of implementing the mighty pro application and measure its efficacy at reducing distress among young women with breast cancer.

Eligibility criteria:
inclusion criteria: * ability to understand and willingness to sign an irb-approved informed consent * age ≥ 18 and ≤ 45 years at the time of consent * female * established patient at atrium health wake forest baptist comprehensive cancer center (ahwfbccc) * histological confirmation of any type and stage (0-iv) of breast cancer * screening (baseline) nccn distress thermometer score ≥ 4 * access to a mobile device for trial purposes and an active email address * ability to read and understand the english language. note: the mighty pro application is available in english only. * as determined by the enrolling investigator, ability of the participant to understand and comply with study procedures for the entire length of the study exclusion criteria: - none

Keywords: cancer-related distress breast cancer young adult cancer
new technique for uretero-ileal anastomosis for patient with bladder cancer who are suitable for orthotopic neobladder

Conditions: Bladder Cancer

Summary: there are many techniques for uretero-ileal anastomosis some of them are antirefluxing for protection of the upper urinary tract with many complications including strictures and pyelonephritis with difficult technical issues and long operation time so a modified technique combining the 2 ureter by wallace technique and implanted them in a single trough in the neobladder making the surgery easier and shorter. this technique was done after informed consent in 45 patients with muscle invasive bladder cancer candidate for radical cystectomy and ileal neobladder diversion

this was a prospective study conducted from 2014 to 2017 in ain shams university, 73 patients were enrolled from outpatient clinic diagnosed with muscle invasive bladder cancer and candidate for radical cystectomy and orthotopic urinary diversion, 45 patients were included according to patient's acceptance and the inclusion and exclusion criteria. after having a written informed consent, all selected patients were assessed by detailed history and physical examination, contrast enhanced pelvi-abdominal computed tomography (ct) scan (for patients with serum creatinine \<1.5 mg/dl). laboratory investigations in the form of complete blood count, coagulation profile, electrolytes, renal and liver function tests. bowel preparation was done to all patients one or two days before operation. cases were diverted using a u-shaped pouch with uretero-ileal anastomosis done in a single trough combining the extramural serous-lined tunnel and wallace techniques.

Eligibility criteria:
the inclusion criteria: * patients with invasive bladder cancer (t2, t3). * good performance status * patients with serum creatinine ≤ 2 mg/dl * prostatic urethra free of tumor. * willing to adhere to the follow up regimen. the exclusion criteria: * patients not fit for surgical intervention. * patients with renal or hepatic dysfunction. * male patients with positive urethral biopsy or diffuse cis. * female patients with bladder neck or vaginal involvement. * concomitant pathological condition in the distal ureters necessitating the excision of a significant segment that hinders proper fashioning of uretero-ileal anastomosis. * cases with markedly dilated ureters.

Keywords: bladder cancer orthotopic diversion wallace sub-serous extramural tunnel.
pediatric and ambulatory research in infectious diseases

Conditions: Otitis; Bronchiolitis; Influenza; Pharyngitis; Varicella; Pneumonia; Gastroenteritis

Summary: many ambulatory networks are mainly based on diagnoses made by first-line physicians not specifically trained to join the network. here we aim to set up a surveillance network on pediatric infectious diseases with an investment in teaching with specific trainings of participating pediatricians, increasing in use of point of care tests, and automated data extraction from the computers of the pediatricians.

107 pediatricians among the 1400 members of the french ambulatory pediatric association, afpa (association française de pédiatrie ambulatoire) were involved in this survey.to belong to the pari network, pediatricians have to use the same software, axi5-infansoft (developed by compugroup medical, nanterre, france) for electronic medical record of children. the pediatricians were trained to the use of point of care tests and to the infectious diagnoses (otitis, pharyngitis, varicella, bronchiolitis, influenza, pneumonia, etc..). the study population consisted of all children under 16 years of age from the patient population for which an infectious disease was diagnosed.

Eligibility criteria:
inclusion criteria: * children under 16 years of age with at least one infectious disease among: * pharyngitis * otitis * pneumonia * influenza * bronchiolitisz * varicella * gastroenteritis * enterovirus disease * bordetella pertussis disease * using the same same software, axi5-infansoft (developed by compugroup medical, nanterre, france) exclusion criteria: * parental refusal

Keywords: vaccination antibiotic treatment point of care test automated data extraction network
denervation for osteoarthritis in the pip-joint efficacy study (dops)

Conditions: Osteoarthritis Finger; Surgery

Summary: the goal of this clinical trial is to compare the effects of a surgical and a non-surgical treatment method in patients with osteoarthritis in the proximal interphalangeal (pip) joint. the main questions it aims to answer are: * are the treatments effective? * is the surgical treatment more effective than the non-surgical treatment? participants will receive surgical treatment (pip joint denervation) or non surgical treatment (patient education plus exercise). researchers will compare the non-surgical and surgical groups to see if pain, patient-reported function, quality of life, movement and grip strength differs between the groups.

this is a parallel group, two-arm, randomized, controlled trial comparing the effects of surgical denevation to patient education plus exercise in patients with symptomatic pip joint osteoarthritis. the research questions are: 1. does any of the treatments denervation of the pip-joint and patient education plus exercise decrease pain, improve patient-reported outcomes, grip strength and range of motion (rom) in pip-joint osteoarthritis? 2. does denervation of the pip-joint decrease pain, and improve patient-reported outcomes grip strength and rom more effectively than patient education plus exercise for pip-joint osteoarthritis? participants will be randomly assigned (1:1) to receive surgical denervation of the pip-joint or education plus exercise. a block randomization scheme with a fixed block size of 10 will be used. patients will be stratified according to gender. sealed opaque envelopes will be used and data analysts will be masked for treatment allocation. assesments will be made at inclusion, and after 3, 6 and 12 months. the studys primary enpoint is 12 months after intervention.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * chronic symptomatic osteoarthritis in the pip-joint. * radiological signs of osteoarthritis on posteroanterior and lateral radiographs assessed by the kellgren-lawrence classification (grade ii-iv) (kellgren \& lawrence, 1957). * clinical signs of pip-joint arthritis. exclusion criteria: * inflammatory arthritis. * ongoing infection in the hand. * inability to co-operate with the follow-up protocol. * intra-articular glucocorticoid, prp or hyaluronic acid injections in the affected joint less than 3 months prior to enrollment.
trial comparing early complications of two techniques in the laparoscopic gastric bypass

Conditions: Obesity

Summary: the purpose of this study is to define and evaluate the early complications between two different surgical techniques used to perform a laparoscopic gastric bypass


Eligibility criteria:
inclusion criteria: * body mass index between 35 with comorbidities and 50 kg/mt2 exclusion criteria: * body mass index \ 50kg/mt2

Keywords: early complications of both techniques fistula rate dehiscence rate reoperation rate and cause
clinical performance of nipt in multiple gestation pregnancies

Conditions: Trisomy 21 in Fetus

Summary: this study plans to evaluate the clinical performance of the maternit21 plus and/or genome laboratory developed test, in the detection of fetal trisomy 21 in circulating cell-free dna extracted from maternal blood samples obtained from women pregnant with a twin gestation.


Eligibility criteria:
inclusion criteria: * subject pregnant with a multiple gestation and received nipt from sequenom laboratories; * subject was 18 or older at the time of nipt exclusion criteria: * none
effect of tafoxiparin to treat primary slow progress of labor including prolonged latent phase and labor arrest

Conditions: Labor, Obstetric

Summary: the study will be designed as a double-blind, placebo-controlled, parallel-group, dose-finding study with one group treated with placebo and three groups treated with tafoxiparin in three different infusion concentration levels, respectively. the intravenous infusion will be initiated by a pre-defined bolus dose infusion.

primary objective to assess the dose-response relationship of tafoxiparin on the labor time defined as the time from the start of continuous infusion of tafoxiparin/placebo as an adjunct treatment to oxytocin, until partus in term-pregnant, nulliparous women requiring labor augmentation due to primary slow progress of labor including prolonged latent phase and labor arrest. secondary objectives to assess the safety and efficacy of tafoxiparin based on the safety and secondary efficacy parameters evaluated in the protocol. pk (pharmacokinetic) response in pregnant women during labor. methodology all term-pregnant, nulliparous women presenting to the delivery ward are potential study patients unless they have already been enrolled in another clinical study. subjects may be pre-informed about the study through the use of advertisements or information at the physician/midwife visits during pregnancy and at hospital admission. the whole study includes the following steps: * screening and baseline including informed consent and randomization * labor * discharge * follow-up at 8 (+/-1)weeks - end of study * safety follow up of infant at 6 months, +/-4 weeks, by telephone interview

Eligibility criteria:
inclusion criteria: 1. pregnant women of ≥18 to ≤45 years of age 2. nulliparous 3. gestational age \> 36 weeks + 6 days confirmed by ultrasound 4. experience slow progress of labor including prolonged latent phase and labor arrest (according to the respective definitions) etc exclusion criteria: 1. subjects with secondary slow progress or secondary labor arrest 2. bmi≥35 during first trimester of pregnancy 3. breech presentation or other abnormal presentations etc

Keywords: primary slow progress prolonged latent phase labor arrest
the acute effects of low-dose tnf-α on glucose metabolism and β-cell function in humans

Conditions: Diabetes Type 2

Summary: type 2 diabetes is characterized by increased insulin resistance and impaired insulin secretion. in addition, type 2 diabetes is associated with low grade inflammation indicated by increased levels of proinflammatory cytokines such as tnf-α. tnf-α has previously been shown to impair peripheral insulin signaling in vitro and in vivo. however, it is unclear whether tnf-α may also affect endogenous glucose production (egp) during fasting and glucose stimulated insulin secretion (gsis) in vivo. we hypothesized that low dose tnf-α would increase egp and attenuate gsis. recombinant human tnf-α or placebo was infused in healthy, non-obese and non-diabetic young men (n=10) during a 4-hour basal period followed by an intravenous glucose tolerance test (ivgtt).


Eligibility criteria:
inclusion criteria: * healthy men * age 20-35 exclusion criteria: * obesity (bmi\>25) * diabetes * chronic disease
10 year review of the experience of the pfna ,tfna the affixus nail

Conditions: Fractured Neck of Femur

Summary: the aim of this study was to investigate the clinical effects of design changes from the use of three different im nail designs in the management of extracapsular hip fractures.

intertrochanteric hip fractures are one of the more common orthopaedic presentations, with an approximate incidence in australia of 230 cases per 100,000 population. the importance of this pathology is well documented being the major fracture-related health care cost and cause of mortality in all sexes over 50 years of age. contemporary fixation of the proximal femur is performed utilising a number of implants adopting different concepts and techniques. cephalomedullary/intermedullary femoral nails (im nails) over the last 15 years have gained popularity. im nails are implanted via a small incision and intermedullary insertion through the greater trochanter, secured by passing a screw or blade through the femoral neck into the femoral head. this nailing technique offers the theoretical benefits of a smaller incision with less tissue dissection and hence reduced blood loss, infection and operating time. as well as a proposed biomechanical advantage due to a shorter lever arm, sharing the load and minimising proximal collapse. biomechanical studies of im nails in the use of extracapsular fractures of the femoral neck have found benefit over existing sliding/compression hip screws (chs). advantages have been observed in combined bending and compression performance to failure. as well as postoperative rigidity in unstable subtrochanteric fractures, and load bearing capability. significantly greater fatigue strength and fatigue life have additionally been shown in cyclic loading assessment and reduced incidence of cut out has been observed, showing benefit over the use of chs. early trials however found a higher rate of operative complications involving im fixation, including fractures at the tip of the nail or related to distal locking. following this several studies have compared the clinical outcomes of chs vs im nails with varying findings questioning the overall patient benefit, especially in stable fracture patterns. from a review of the past literature the common trend is a longer operative time and higher associated blood loss with chs, but fewer intraoperative surgical related complications and less fluoroscopic time with the use of nails. im nail use has shown to offer better post-operative ambulatory function and reduced limb shortening but it appears due to the early complications of this technique numerous variations in implant design have emerged. purpose in recent years further development has occurred in nail design in an attempt to reduce the incidence of fixation failure. the aim of this study was to investigate the clinical effects of these design changes from the use of three different im nail designs in the management of extracapsular hip fractures.

Eligibility criteria:
inclusion criteria: . fractured neck of femur exclusion criteria: . not fractured neck of femur
prospective study to assess the safety and effectiveness of tixel treatment on dry eye symptoms in asian patients

Conditions: Dry Eye Syndromes; Dry Eye

Summary: pilot study where effect of standard tixel treatment as used for periorbital wrinkles would be assessed on dry eye disease symptoms and signs in asian patients.

safety assessment will be asses via ae/sae reporting and impact assessment of the effect of the treatment on dry eye symptoms and signs through multiple

Eligibility criteria:
inclusion criteria: 1. ≥ 18 years. 2. osdi score of at least 23. 3. noninvasive tear film break up time (nikbut) ≤ 10 seconds. 4. no other eye or skin or immune problems. 5. willing and able to provide written informed consent. 6. willing to participate in all study activities and follow study instructions. exclusion criteria: 1. pregnancy and/or breastfeeding. 2. lesions in the periorbital area. 3. acute severe blepharitis. 4. acute conjunctivitis. 5. concomitant anterior eye disease. 6. has undergone outdoor/sunbed tanning during the last 4 weeks. 7. is unwilling to follow the tixel aftercare instructions after each of the three tixel treatments. 8. active herpes simplex or tendency for herpes simplex in the periorbital area (meaning the subject has had the condition previously). 9. current skin cancer, malignant sites and/or advanced premalignant lesions or moles in the treatment area. 10. an impaired immune system condition or use of immunosuppressive medication. 11. collagen disorders, keloid formation and/or abnormal wound healing. 12. previous invasive/ablative procedures in the areas to be treated within 3 months prior to initial treatment or plans for such treatment during the course of the tixel treatments, or before complete healing of the treatments has occurred. 13. has taken any medications (including via topical application), herbal treatment (oral or topic), food supplements or vitamins, which may cause fragile skin or impaired skin healing during the last 3 months. 14. has used oral isotretinoin (accutane® or roaccutan®) within 3 months prior to treatment. 15. history of bleeding coagulopathies or use of anticoagulants. 16. tattoos or permanent makeup in the areas to be treated. 17. burned skin, blistered skin, irritated skin, or sensitive skin in any of the areas to be treated. 18. thread lifting of the area to be treated in the last 3 months.
improving provider counseling interventions in hiv practice

Conditions: HIV Infections

Summary: hypothesis: hiv clinicians trained to deliver brief counseling messages and receiving cues from a brief computer survey on risk behaviors of their patients can counsel have an impact on patient's risk behaviors.

this is a randomized controlled study. the purpose of this study is to assess the impact of the cue sheet as an aid to targeted provider behavioral counseling. all enrolled participants are hiv+ adults seen for regular medical care at a site affiliated with the johns hopkins aids service. after consenting, participants will take an audio-assisted computer interviews to collect patient risk assessment data. for participants randomized to the intervention arm, the printed output on risk behaviors is then given to the provider along with cues for staged-based counseling for use during the same visit. participants in the control arm take the same computerized risk assessment but there are no printed cue sheets. risk behaviors of all participants are assessed at entry, at 6 months, and at 12 months. the main outcome measure is change in hiv transmission behaviors at 12 months for those in the intervention arm compared to the control arm.

Eligibility criteria:
inclusion criteria: * hiv seropositive * english speaking exclusion criteria: * cannot give informed consent