Kornimate/medical-research-clean huggingface dataset:
the role of neuroactive steroids in stress, alcohol craving and alcohol use in alcohol use disorders

Conditions: Alcohol Use Disorder

Summary: to use pregnenolone (preg; 300; 500mg) daily versus placebo (pla) as a probe to assess the role of neuroactive steroids in individuals with alcohol use disorder (aud).

the study aims to examine the effects of preg on a) alcohol craving, mood and neuroendocrine reactivity to brief, guided imagery exposure to stress, drug cues and neutral situations in the laboratory and b) daily alcohol intake, craving, cognition and mood in men and women with aud; and c) sex differences in all of these outcomes.

Eligibility criteria:
inclusion criteria: * male or female individuals, ages 18 to 68. * subjects must meet current diagnostic and statistical manual of mental disorders 5th edition (dsm-v) criteria for alcohol use disorder; documented positive urine toxicology screen for alcohol at intake or collateral information from family members, significant others, room-mates etc., on recent use. * subject has voluntarily given informed consent and signed the informed consent document. * able to read english and complete study evaluations. exclusion criteria: * women who are pregnant, or nursing or are of childbearing potential and not practicing an effective means of birth control. * meet current criteria for use disorder on another psychoactive substance, such as, heroin, amphetamines, hallucinogens/phencyclidine (pcp), excluding alcohol and nicotine. * any current use of opiates or past history of opiate use disorder (assessed via urine toxicology and self report). * current use of any psychoactive drugs (urine toxicology), including anxiolytics, naltrexone or antabuse. * any psychotic disorder or current axis i psychiatric symptoms requiring specific attention. * significant underlying medical conditions such as cerebral, renal, thyroid or cardiac pathology which in the opinion of study physician would preclude patient from fully cooperating or be of potential harm during the course of the study. * hypotensive individuals with sitting blood pressure below 90/50 mmhg.
monosodium glutamate on gastric emptying

Conditions: Delayed Gastric Emptying

Summary: children with a radionuclide gastric emptying test with abnormal results will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. the purpose of the study is to determine if a single dose of monosodium glutamate can shorten the gastric emptying time.

there is evidence that monosodium glutamate has effects on synapsis at the gastric and duodenum level that results in stimulation of contractility resulting on increase rate of gastric emptying. the purpose of the study is to demonstrate that the administration of a single dose of monosodium glutamate can shorten the gastric emptying time. patients with a prior study indicating a delay of gastric empting time, will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. each patient will serve as her/his own control. results will be analysed by pair-t test.

Eligibility criteria:
inclusion criteria: * children with delayed gastric emptying not receiving prokinetic medication in the last 72 hours exclusion criteria: * prior gastrointestinal surgery, patients with known history of reaction to monosodium glutamate. history of neoplasia, autoimmune or inflammatory bowel disease.

Keywords: delayed gastric emptying children monosodium glutamate
reflex rolling versus lung squeezing techniques on pulmonary functions in premature neonate with pneumonia

Conditions: Pneumonia

Summary: respiratory problems in neonates are one of the leading causes of neonatal morbidity and mortality in developing countries. these respiratory problems are seen in premature neonates, which mainly include respiratory distress syndrome (rds), pneumonia, requiring ventilatory assistance or oxygen support

the purpose of this study is to compare between the effect of reflex rolling and lung squeezing techniques on pulmonary functions in premature neonates with pneumonia.

Eligibility criteria:
inclusion criteria: * 1) preterm neonates with pneumonia. 2) neonates with 30-37 weeks of gestation admitted to nicu. 3) they were free from any major congenital malformation. 4) they were clinically and thermodynamically stable. exclusion criteria: * 1) treatment with neurotropic drugs. 2) interventricular hemorrhage. 3) temperature \>38 4) respiratory and cardiac congenital anomalies. 5) seizures. 6) surgical procedures. 7) genetic disorders 8) any segmental or lobar collapse confirmed on chest x-ray. 9) major airway interventions including change of endo-tracheal tube, hand ventilation or bronchial lavage in the previous 12 hours.
ani and remifentanil in skull pin fixation.

Conditions: Pain, Procedural

Summary: forty patients were enrolled, and all patients used total intravenous anesthesia (remifentanil-propofol based total intravenous analgesia) as anesthesia induction and maintenance. according to the preliminary data of this department, patients who underwent intracranial surgery for skull pin fixation used remifentanil 5.0-6.0 ng/ml, while the hemodynamics is relatively stable. therefore, when this plan is implemented, the patient needs to be under the same depth of anesthesia (monitored by electroencephalography, maintaining a value of 40-60), first start with remifentanil 6.0 ng/ml, and use the up and down method as adjust 0.5 ng/ml of concentration of remifentanil each time. an analgesia nociception index(ani) lower than 30 and hyperdynamics (the increased heart rate(hr) and mean blood pressure(mbp) up 20% of baseline or hr\>100bpm and arterial blood pressure(abp)\>180/100mmhg) indicates insufficient analgesia, therefore increase it by 0.5 ng/ml; an ani higher than 30 and stable hemodynamics (the changes of hr and mbp within 20% of baseline or hr\<50bpm and abp\<90/50mmhg) indicates that analgesia is acceptable, and the next patient will decrease it by 0.5 ng/ml during skull pin fixation. data collection: heart rate, measure blood pressure, analgesia nociception index, bispectral index, concentrations of propofol and remifentanil before 2 mins, during, 5, and 15 mins of skull pin fixation were recorded and analyzed.


Eligibility criteria:
inclusion criteria: 1. must be at least 20 years old and less than 80 years old 2. with anesthesia risk grade below grade three (including grade three) (asa i\~iii) 3. patients who are expected to undergo intracranial surgery for skull pin fixation exclusion criteria: 1. those with anesthesia risk classification asa class iv or higher 2. those who are allergic to opioid analgesics or propofol drugs 3. emergency patients

Keywords: remifentanil pain analgesia nociception index
a study to investigate csl312 in subjects with hereditary angioedema (hae)

Conditions: Hereditary Angioedema

Summary: this is a multicenter, randomized, placebo-controlled, parallel-arm, phase 2 study to investigate the clinical efficacy, pharmacokinetics, and safety of csl312 as prophylaxis to prevent attacks in subjects with hae.


Eligibility criteria:
inclusion criteria: * male or female * aged ≥ 18 to ≤ 65 years * a diagnosis of c1-inh hae or fxii/plg hae; * for subjects with c1-inh hae: ≥ 4 hae attacks over a consecutive 2-month period during the 3 months before screening, as documented in the subject's medical record. exclusion criteria: * history of clinically significant arterial or venous thrombosis, or current clinically significant prothrombotic risk * history of an uncontrolled, abnormal bleeding event due to a coagulopathy, or a current clinically significant coagulopathy or clinically significant risks for bleeding events * known incurable malignancies
the efficacy of reiki in the treatment of fibromyalgia

Conditions: Fibromyalgia

Summary: the purpose of this study is to investigate the effectiveness of reiki in the treatment of fibromyalgia (fm), a condition characterized by widespread muscle pain and stiffness, often accompanied by sleep disturbance, headaches, irritable bowel syndrome, and psychological distress. reiki is a form of energy medicine in which practitioners reportedly access universal life energy to heal patients, either by direct contact at specific hand positions or from a distance.

fibromyalgia is one of the most common rheumatologic diagnoses. treatment is generally unsatisfactory and most randomized, controlled treatment trials have been unable to demonstrate a sustained effective intervention. a vast body of anecdotal literature as well as two randomized controlled trials suggest that reiki may be an effective treatment for fm, appearing to relieve pain and improve psychological well being. reiki appears to have no adverse effects and can eventually be self-administered, making it a low-risk, low-cost, potentially patient-empowering intervention. this study will investigate the efficacy of reiki in the treatment of fm. one hundred reiki-naive fm patients will be recruited from a chronic fatigue referral clinic and will participate in an 8-week trial. patients will be randomized into one of two reiki groups (direct-contact and distant reiki) or one of two control groups (sham and placebo). patients will receive either reiki or placebo 16 times during the course of the study. patients will be assessed at study entry, at weeks 4 and 8, and 12 weeks post-treatment.

Eligibility criteria:
inclusion criteria * fibromyalgia without concurrent medical conditions associated with chronic pain, such as diabetic neuropathy, systemic lupus erythematosus, or severe degenerative joint disease * willing to undergo randomization and attend treatments regularly * willing to stay on a stable medical regimen during the entire 8-week trial and use only acetaminophen for breakthrough pain * live within a one-hour drive of the study site exclusion criteria * received reiki or any other energy medicine (therapeutic touch, qi gong, shen therapy, etc.) * pregnant * pending litigation or disability claim related to fm

Keywords: fibromyalgia, reiki, energy medicine
the phonak edulink-system in students with specific performance deficits in speech-in-noise intelligibility

Conditions: Auditory Processing Disorder

Summary: in the management and remediation of students with specific performance deficits in speech-in-noise intelligibility, most often, a "triad" approach for treatment is used, which includes direct therapy, compensatory strategies, and environmental modifications. the purpose of the study is to determine whether a new hearing aid, the phonak edulink-fm system, can improve specific performance deficits in speech-in-noise intelligibility. participants will complete a test battery related to auditory processing, as well as some psychological tests and questionnaires. one group of participants with specific performance deficits in speech-in-noise intelligibility will receive the hearing aid for use in school; a second group will not. the effect of this treatment on auditory performance, school performance and satisfaction, attention and verbal learning and memory, self concept, behavior and listening effort following 26 weeks of hearing aid use will be compared across the groups.


Eligibility criteria:
inclusion criteria: * diagnosis of specific performance deficits in speech-in-noise intelligibility based on two or more standardized tests of auditory processing in noise including retests. * students in the 1st to 4th class of primary school exclusion criteria: * hearing loss, defined as: * air conduction pure tone thresholds (250-8000 hz) exceeding 20 dbhl * air-bone gaps, even in the presence of normal sensitivity, exceeding 10 dbhl * abnormal tympanogram * history or diagnosis of behavioral and/or emotional disorders meeting icd-gm-criteria (including attention deficit/hyperactivity disorders (ad-/hd) * non-german speaking * cognitively impaired children (iq \< 85) * children currently using psychoactive medication * students with special education

Keywords: auditory processing disorder speech-in-noise intelligibility
64cu/68ga labelled eb-ss-cpt pet/ct scan in colorectal cancer

Conditions: Colorectal Cancer

Summary: positron labeled camptothecin based pet imaging is a new imaging technique that uses positron isotopes such as 68ga/64cu for pet/ct (mr) imaging. it is expected to have significant clinical significance in staging and detecting primary and metastatic head and neck cancer, oral cancer, and colorectal cancer tumors.

cpt, a botanical anticancer drug, is a mechanism that inhibits dna synthesis and thus exerts anticancer effects by using topoisomerase i as its target of action, and has shown good efficacy in digestive system tumors and head and neck tumors, etc. previous research result showed that amphiphilic eb-ss-cpt formed nanoparticles by self-assembly, bound to albumin in vivo and released cpt by breaking disulfide bonds under high gsh conditions in tumor tissues, effectively enhancing the pharmacokinetics and biodistribution of camptothecin, thereby improving therapeutic efficacy and in this study, the sensitivity of colorectal cancer cells to the drug was also demonstrated. in this study, 64cu-nota-eb-ss-cpt (hereafter 64cu-eb-cpt) was generated by posionuclide 64cu-labelled eb-ss-cpt for pet/ct imaging alone and showed better tumour enrichment compared to the 64cu-labelled cpt group. eb-cpt is expected to be more enriched in tumour tissue through the epr effect of its nanoparticles, and 64cu is also a promising radionuclide for quantitative analysis using pet/ct imaging. the formation of 64cu-eb-cpt or 68ga-eb-cpt by labelling eb-cpt with the positronium nuclide 64cu or 68ga is expected to be enhanced by the epr effect of the precursors (the enhanced permeability and retention effect of solid tumours). the epr effect (enhanced permeability and retention effect) refers to the tendency of molecules or particles of certain sizes to accumulate in tumour tissue relative to normal tissue) is expected to enrich the drug in the tumour area and allow early diagnosis of tumour patients by pet/ct imaging with the preceding positronuclide 64cu or 68ga, which can help in the staging of tumours and the development of treatment plans.

Eligibility criteria:
inclusion criteria: * in the near future (within 2 months), patients who plan to undergo puncture biopsy or undergo tumor surgical treatment or are clinically highly suspected of cancer (including primary and tumor recurrence and metastasis) * able to understand and voluntarily sign informed consent forms, with good compliance exclusion criteria: * severe abnormalities in liver and kidney function * suffering from claustrophobia or other mental illnesses * pregnant, pregnant, and lactating women

Keywords: colorectal cancer pet/ct cpt
home-based self-management and cognitive training changes lives (hobscotch)-parkinson's disease (hobscotch-parkinson's)

Conditions: Parkinson Disease; Cognitive Dysfunction; Memory Disorders

Summary: the goal of this pilot study is to assess the feasibility of adapting and delivering the existing home-based epilepsy self-management intervention, hobscotch, for people with parkinson's disease (pd) the main questions it aims to answer are: 1. can the current hobscotch program be adapted for people with pd? 2. will people with pd experience improved quality of life similar to that found in people with epilepsy after participating in the hobscotch program? participants will be asked to: * attend nine, one-hour virtual (online and/or by telephone) hobscotch-pd sessions with a one-on-one certified hobscotch-pd coach * complete a brief clinical questionnaire about their diagnosis of pd * complete two questionnaires before and after the hobscotch-pd sessions about their quality of life and about memory and thinking processes * keep a short daily diary about their pd symptoms and use of the self-management strategies taught in the hobscotch-pd program * complete a brief satisfaction survey after the entire hobscotch-pd program


Eligibility criteria:
inclusion criteria: * age 30 - 75 years * diagnosis of parkinson's disease per participant's provider * literate, english-speaking with grade 12 or equivalent in education * self-reported cognitive/memory difficulties * telephone and internet access exclusion criteria: * cognitive dysfunction that precludes participation in giving informed consent * significant visual impairment precluding reading or writing * no reliable telephone or internet access

Keywords: parkinson disease memory cognitive training self-management
research on the blood- cooling - toxin - removing - stasis - dispersing protocol evaluation of hench-schonlein purpura

Conditions: Purpura, Schoenlein-Henoch

Summary: due to high incidence of renal damage by hench-schonlein purpura(hsp) is the key to affect prognosis, this project moves the research emphasis forward in line with the idea of "prevention of progress of disease", which concerns on traditional chinese medicine(tcm) clinical research scheme evaluation of hsp, evaluates the renal damage and disease recurrence as the end event, and comes to the evaluation through the comparative study that the vantage point of the scheme of syndrome differentiation and treatment in detoxification, cooling blood and removing blood stasis to the conventional treatments can reduce kidney damage and recurrence rate.

target：optimize the tcm scheme of syndrome differentiation and treatment of hsp in line with the idea of blood- cooling - toxin - removing - stasis - dispersing under the path of combination between disease differentiation and syndrome differentiation, and regards reducing the rate of the recurrence of hsp and kidney damage as the end point of evaluation indexes, to evaluate the clinical efficacy of the scheme scientifically. main research contents: retrospective case investigation, analysis and research on literature, research on clinical assessment of the scheme of syndrome differentiation and treatment. methods：with a series of compounds as the main interference factors, choosing the sample estimation of superiority design and adopting the test methods of randomized, double-blind, placebo-controlled to carry out the research of multicenter clinical efficacy evaluation. it summarizes the advantages and rules of syndrome differentiation and treatment in tcm by means of the comparative study, which provides technical guidelines for the industry and sets an example to summarize the key common technology of clinical research, and also improves the evaluation level of tcm clinical research and efficacy.

Eligibility criteria:
inclusion criteria: * to comply with the diagnostic standard of purpura in tcm and hench-schonlein purpura in western medicine; * to comply with the diagnostic standard of tcm syndrome differentiation; * age between 5 and 18; * without similar herbal treatment a week before being included; * informed consent form is required to be singed. exclusion criteria: * fall short of the diagnostic standard of purpura in tcm and hench-schonlein purpura in western medicine; * fall short of the diagnostic standard of tcm syndrome differentiation; * older then 18 years or younger then 5years; * take similar herbal treatment within a week before being included; * can not take the drug according to the regulation or follow-up on time * patients combine serious primary disease in respiratory、gastrointestinal、hemopoietic、renal，or psychosis,or pestilence; * allergic to drugs of this research or others; * human subject of other clinical research in the nearly tow weeks.

Keywords: hench-schonlein purpura renal damage relapse end event tcm syndrome
effect of low glycemic index diet on body composition and mechanism of obese women

Conditions: Obesity

Summary: excessive body weight and obesity have reached epidemic proportions over the last few decades, which may cause many chronic diseases. maintaining a healthy life style could decrease the risk for obesity, metabolic syndrome and cardiovascular disease. the study aimed to evaluate long-term low glycemic index (gi) diet intervention on lipid profile, body composition and the mechanism of obese women. the pilot study will recruit twenty healthy subjects, and served test food to determine low gi food. in the experiment period, twenty women age from 20-50 years will be recruited. to be included in the study, subjects should have a bmi above 24 kg/m2, or the either one (fat mass ≧ 30% or waistline \> 80 cm). before dietary intervention, participants will receive food choice table and dietary questionnaires to record their dietary intake. the study will be a randomized, crossover, controlled clinical trails. the experiment period have six weeks, each participants will provide low gi diet (lunch and dinner). on the 0, 3, 6 week, subjects will measurement their body composition (body weight, body mass, waist and hip circumferences) and collect fasting blood samples to analysis the lipid profile, free fatty acid, blood sugar, insulin, adiponectin, leptin and fatty acid synthesis enzymes. statistical analysis will be performed by paired t-test. the study expect that long-term low gi diet intervention have beneficial effects on regulate body composition of obese women.


Eligibility criteria:
inclusion criteria: * bmi above 24 kg/m2, or the either one ( fat mass ≧ 30% or waistline \> 80 cm ) exclusion criteria: * cardiovascular disease * type 2 diabetes mellitus or impaired glucose tolerance * serious liver or renal disease, gastro-intestinal disease * proceed serious diet control for formerly three months * take any supplemental food products or medications known to influence lipid or carbohydrate metabolism

Keywords: obesity body composition adipocyte-derived cytokine low glycemic index