Kornimate/medical-research-clean huggingface dataset:
bispectral index monitoring in pediatric cataract surgery: a comparative study using propofol-midazolam versus sevoflurane anesthesia

Conditions: Ophthalmic

Summary: ocular alignment will be studied in children having cataract surgery that will be divided into two groups, one group will be anesthetized using sevoflurane anesthesia (group a), and the other will be anesthetized by midazolam bolus and propofol infusion (total intravenous anesthesia, tiva) (group b). in both groups depth of anesthesia will be monitored by bispectral index monitor.

after signing the informed consent by children parent, child will be transferred to the operating room and will be connected to pulse oximetry, non invasive blood pressure and electrocardiogram(ecg), child will be anesthetized by sevoflurane 8% for cannula insertion, then in group a, sevoflurane will be continued with 2%, and iv atracurium 0.25mg/kg, and paracetamol 15mg/kg iv will be given. in group b, sevoflurane will be discontinued and propofol bolus1mg/kg iv, midazolam 0.05 mg/kg iv, atracurium 0.25 iv, and paracetamol 15mg/kg iv then propofol infusion will start immediately according to mcfarlan protocol for manual syringe pump for pediatrics. for first 10 minutes 15mg/kg, second 10 minutes 13mg/kg, third 10 minutes 13mg/kg, fourth 10 minutes 11mg/kg, fifth 10 minutes 11mg/kg, and will be continued on this rate for the end of surgery. bispectral index monitor(covidien, germany) will be attached to child forehead after cleansing it with alcohol 70%. after adequate jaw relaxation , trachea will be intubated with adequate size endotracheal tube and attached to anesthesia machine ( general electric, carestation 650).volume controlled ventilation (vcv) will start with tidal volume(vt) 6-8 ml/kg, respiratory rate (rr)16-20 according to end-tidal carbon dioxide (co2)35-40mmhg. flow of fresh gas rate 2 l/minute. standard circuit system connection for pediatric will be used. heart rate ,peripheral oxygen saturation (spo2), non invasive blood pressure, end-tidal carbon dioxide (etco2), and bispectral index monitor will be measured every 5 minutes. 6 ml/kg of ringer will be given infusion slowly.

Eligibility criteria:
inclusion criteria: 0-children american society of anesthesiologist (asa )grade l, ll of both sex 0-congenital or traumatic cataract exclusion criteria: 0- syndromes involving cataract. 0- children with neurologic disorders. 0- children on anti-psychotic medication. 0- hypersensitivity to any anesthetic used.

Keywords: propofol ocular alignment tiva
the efﬁcacy of the integrated water jet channel colonoscopy in water exchange method

Conditions: Colonoscopy; Colon Disease

Summary: this prospective randomized controlled trial compared integrated water jet channel colonoscopy with traditional accessory channel colonoscopy in cecal insertion time among patients undergoing we method colonoscopy.

when the we method colonoscopy were done with the accessory channel for both infusing and suctioning of water. the water had to be suctioned or infused alternatively and increaed the insertion time. with the new designed endoscopy that integrated a separate water jet channel for infusing water, infusing and suctioning of water can be done at the same time. besides, water jet pumping system could provide a powerful jet to help us open the collapse lumen and keep an appropriate distance between the mucosa and the lens, thus preventing loss of visualization. it will help the colonoscopist to find the way during insertion.

Eligibility criteria:
inclusion criteria: * underwent fully sedative colonoscopy with we method in the outpatient department exclusion criteria: * age \ 80 years old * without standard colon preparation * allergy to meperidine or propofol * with a history of partial colectomy * refusal to provide written informed consent.

Keywords: water exchange water jet channel colonoscopy colonoscopy cecal insertion time adenoma detection rate
comparison of effectiveness of hand versus rotary instrumentation in pulpectomy of primary second molar teeth.

Conditions: Irreversible Pulpitis (toothache)

Summary: to provide an effective technique for pulpectomy in primary second molar teeth in pakistani population, local studies are required. no local studies have been done so far and limited number of international in vivo studies have been conducted previously. hence this study will evaluate the effectiveness of this technique in pakistani population. if results of this study will be significant in favor of this technique, it will be applied with confidence in same population. there will be better compliance of patients as procedure will be done in single visit.


Eligibility criteria:
inclusion criteria: 1. children of both genders having age 4-6.5 years 2. children having signs and symptoms of irreversible pulpitis in their second primary molar teeth on clinical examination as per operational definition. exclusion criteria: 1. children having previously accessed pulpectomy assessed clinically and on periapical radiographs. 2. children having acute/chronic abcesses in teeth under consideration seen clinically. 3. children having furcal or periapical radiolucency around teeth under consideration seen on periapical radiograph. 4. diabetic, haemophilic or medically compromised children found on history 5. children who fail to attend appointments.
impact of speac® system data on therapeutic decisions related to convulsive seizure patients with a recent non-diagnostic emu visit

Conditions: Epilepsy

Summary: this is an open label, randomized, prospective study of the impact on healthcare utilization of a surface electromyography (semg) based seizure monitoring and alerting system for veterans with seizures with upper extremity motor involvement, who have had a recent non-diagnostic emu stay.


Eligibility criteria:
inclusion criteria: 1. subject is a veteran with a reported history of motor seizures (epileptic, non-epileptic or unknown) with upper extremity motor involvement. 2. subject has completed a non-diagnostic emu stay within the last two years. 3. male or female between the ages 22 to 99. 4. if female and of childbearing potential, subject must agree to not become pregnant during the trial. 5. can understand and sign written informed consent or will have a legally authorized representative (lar) who can do so, prior to the performance of any study assessments. 6. subject or primary caregiver must be competent to follow all study procedures. 7. subject must be willing to use the seizure monitoring and alerting system for a prolonged period (up to five months), for a minimum of 30 hours/ week. exclusion criteria: 1. the subject cannot be pregnant, or nursing. 2. the subject cannot be sensitive or allergic to adhesives or tapes. 3. the subject may not be enrolled in another clinical trial. 4. the subject is homeless or in a home without a power supply.
the safety and feasibility of costal bone marrow aspiration during thoracic surgery

Conditions: Non Small Cell Lung Cancer

Summary: this pilot trial is designed to evaluate the feasibility and safety of obtaining bone marrow from costal aspiration during surgery. the investigators hypothese that sufficient bone marrow-derived hspc's (which represent only 0,1% of the total bone marrow fraction) can be derived by rib bone marrow aspiration for ex vivo single-cell evaluation, optimization of a 3d bmn platform and preclinical ex/in vivo assessment in patient-derived organoids and murine xenograft models.

this pilot trial is designed to evaluate the feasibility and safety of obtaining bone marrow from costal aspiration during surgery. previous trials demonstrated the feasibility of micro-metastasis detection in rib marrow aspirate. this procedure appears safe since no adverse events were documented during previous trials. the investigators hypothesize this technique can be used to obtain sufficient bone marrow-derived hspc's (which represent only 0,1% of the total bone marrow fraction) for ex vivo single-cell evaluation, optimization of a 3d bmn platform and preclinical ex/in vivo assessment in patient-derived organoids and murine xenograft models. the use of rib marrow eliminates the need for extra incisions because the cuts made for trocar placement or the thoracotomy can be re-used. therefore, the investigators hypothesize that the patients undergoing costal bone marrow aspiration during surgery will not experience extra discomfort. every patient undergoing thoracic surgery is treated according to eras protocols with a major emphasis on pain control. if the feasibility and safety of bone marrow aspiration are confirmed by this pilot trial, the investigators plan to conduct a large-scale study in which they will collect and bank blood, bone marrow and tumor per nsclc patient. with this unique autologous biological material collection, the investigators aspire to conduct innovative research into the current resistance mechanisms of nsclc to immunotherapy;

Eligibility criteria:
inclusion criteria: * patient undergoing thoracic surgery for a confirmed or suspected lung cancer exclusion criteria: * uncertainty of pre-operative diagnosis, exception is per-op frozen section analysis confirming malignity * asa ≥ 3 * bleeding disorders
survival outcomes of multiple myeloma patients admitted on assiut clinical hematology unit

Conditions: Multiple Myeloma Survival Outcome

Summary: our study will discuss survival outcomes of multiple myeloma patients admitted on assiut clinical hematology and role of neutrophil to lymphocyte and lymphocyte to monocyte ratios as prognostic factors in multiple myeloma.

what are survival outcomes and the prognostic value of neutrophil to lymphocyte ratio of multiple myeloma patients admitted on assiut clinical hematology unit? multiple myeloma (mm)is a plasma cell neoplasm associated with its characteristic clinical complications: anemia, infections, renal impairment or bone destruction. mm is the second most commonly diagnosed hematological neoplasm, with an incidence rate of 6.2 per 100 000 individuals . survival outcomes have remained constant over the past few decades; therefore, mm is still considered incurable. however, the increasing use of autologous stem cell transplantation (sct) and the introduction of novel therapeutic agents, such as thalidomide and bortezomib, have improved the survival of myeloma patients . relationship between inflammation and cancer have been established. some inflammatory factors from accessory cells in tumor milieu, such as interleukin-1 (il-1), il-6, and tumor necrosis factor-alpha (tnf-α), facilitated cancer cells' invasiveness . further studies exhibited the reactive oxygen and nitrogen from inflammatory cells induced mutation of some tumor suppressor genes, and inflammatory factors such as il-6 and prostaglandin e2 (pge2) caused dna methylation, which both played an important role in tumorigenesis. accordingly, neutrophil to lymphocyte ratio (nlr) coinciding with rationales supported by numerous studies, could offer a precise potency in predicting prognosis of cancers. in fact, many studies already demonstrated the prognostic significance of nlr in various cancers consistently, a number of meta-analyses further confirmed this view in colorectal cancer, lung cancer, ovarian cancer, breast cancer, and lymphoma and others.

Eligibility criteria:
inclusion criteria: clinical and laboratory diagnosis of multiple myeloma * multiple myeloma patients received chemotherapy in our unit. exclusion criteria: * waldenstrom macroglobulinemia * mgus * amyloidosis * other plasna cell disorders
an effectiveness and toxicity of cyberknife based radiosurgery for parkinson disease

Conditions: Parkinson Disease

Summary: clinical objective of the study is estimation of effectiveness and safety of cyber knife based functional radiosurgery for parkinson disease patients suffering from tremor.

basic treatment patients with parkinson's disease (pd - parkinson's disease) or essential tremor (et - essential tremor) is a pharmacotherapy. in the case of lack of its effectiveness, the gold standard procedure is deep brain stimulation (dbs). despite the proven efficacy, still remains a group of patients not eligible for this treatment. in such cases, ablation within the deep structures of the brain (thalamotomy, subthalamotomy, pallidotomy) can be considered. thermoablation and radiosurgery (srs - stereotactic radiosurgery) are used: srs is prefered for patients who are not candidates for invasive procedures. 27 patients will be enrolled in this study. all patients will be immobilized in thermoplastic masks and planned (rt) on the base of ct/mri fusion. the initial total dose in the target volume (thalamic nuclei complex - vop and voa ) will be 70 gy given in one fraction. the dose will be escalated every 5 gy and the treatment effect and possible side effects will be evaluated. dose escalation will be finished at a dose at which the effect of treatment will be satisfactory, or if side effects are unacceptable. the highest dose tested dose will be 110 gy. three patients will be irradiated with particular doses and observed at least 3 moths; then study will be continued. patients will be controlled 3, 6, 9, 12, 18 months after treatment completion and, next every each 6 months. neurologic and neuropsychologic status, local effect (mri ) and eventual toxicity will be checked during follow-up (fu).

Eligibility criteria:
inclusion criteria: * idiopatic parkinson disease (pd) * lack of effective pharmacotherapy * lack of possibilities of qualifications to dbs (deep brain stimulation) procedure * informed consent for participation in the study and for radiotherapy exclusion criteria: * age under 18 * pregnancy * other than pd induced tremor * dementia, psychosis. * poor performance status * atrophic cerebral changes, structural changes in basal nuclei * lack of informed consent.

Keywords: tremor parkinson disease functional radioablation cyber knife radiosurgery
characterizing the gut microbiota alteration associated with severe acute malnutrition

Conditions: Severe Malnutrition; Malnutrition; Infant Nutrition Disorders; Child Nutrition Disorders; Kwashiorkor; Marasmus

Summary: the investigators performed two case-control studies in niger and senegal analysing fecal microbiota to characterize the specificity of the gut microbiota alteration associated with severe acute malnutrition (sam).

fecal samples of cases (severe acute malnutrition (sam) ascertained according to the who definition) and controls (asymptomatic healthy children ascertained by clinical and anthropometric criteria) were analysed by v3v4 16s rrna sequencing, redox and ph measurement and using specific polymerase chain reaction targeting methanobrevibacter smithii and bacteroides thetaiotaomicron. based on the literature and oxydative stress reported in sam, the investigators tested if the proportion of aerotolerant prokaryotes is increased among gut prokaryotes enriched in sam in comparison to prokaryotes enriched in controls. the investigators further linked this to fecal redox potential and assessed the total number of bacteria in feces by flux cytometry.

Eligibility criteria:
inclusion criteria: * children aged 0-59 months of varying nutritional status from niamey (niger) and dakar (senegal). exclusion criteria: * absence of parent or patient consent, antibiotic administration \<2 months before stool collection and insufficient fecal amount. exclusion criteria for controls included any form of malnutrition, presence of fever, acute respiratory infection (cough), acute or chronic diarrhea in the previous 4 weeks. symptoms and complications of malnutrition (cough, fever, diarrhoea, vomiting) nor other form of malnutrition (moderate to severe stunting and underweight) were not a reason of exclusion for cases since they are considered as direct consequence and part of severe acute malnutrition.
rtms as a treatment of visceral pain secondary to malignancy

Conditions: Malignancy

Summary: the purpose of this study is to assess the efficacy of rtms over primary motor cortex in patients suffering from malignant visceral pain. thirty four patients were included in the study. they are divided randomly into 2 groups using closed envelop as real rtms group and sham group. real rtms over the hand area of motor cortex (20 hz, 10 trains with inter train interval 30 second with total pulses 2000, intensity 80% of motor threshold) every day for ten consecutive days (5 days/week) and the coil elevated and angled away from the head as sham stimulation. patients were evaluated by verbal descriptor scale (vds), visual analog scale (vas), and hamilton rating scale for depression (ham-d) at the baseline, after 1st, 5th, 10th session, 15 day and 1 month after end of sessions. serum human dynorphin (dyn) level was measured at baseline, 5th and 10th session.


Eligibility criteria:
inclusion criteria: * all patients within age group 18-65 years with malignant visceral pain resistant to medical treatment for at least 2 months or associated with significant adverse effect from medication was involved in this study. exclusion criteria: * we excluded patients with intracranial metallic devices or with pacemakers or any other device. we also excluded those with extensive myocardial ischemia, unstable angina and those known to have epilepsy.

Keywords: vas vds ham-d visceral pain malignancy rtms motor cortex analgesia dynorphin
effect of topical application of black pepper essential oil and peripheral catheter insertion

Conditions: Vein; Spasm; Patient Satisfaction; Nurse Scope, Practice

Summary: the investigators aimed to determine the effects of topical application of black pepper essential oil on peripheral intravenous catheter insertion success.this randomized controlled trial was carried out on 60 patients randomly assigned to either the experimental group (n=30) or the control group (n=30) reporting to the endoscopy unit of the clinic between may 2019 and october 2019. in the experimental group, black pepper essential oil was used to increase vein degree before the procedure, while in the control group, no extra interventions were applied. the time taken in determining an appropriate vein, time taken for successful catheter insertion, and the patient's and nurse's satisfaction after the process were recorded.

introduction: the literature describes many techniques to increase vein visibility and palpability that facilitate peripheral intravenous catheter insertion. however, there is only one study examining the effect of topical essential black pepper oil on veins. the investigators aimed to determine the effects of topical application of black pepper essential oil on peripheral intravenous catheter insertion success. methods: this randomized controlled trial was carried out on 60 patients randomly assigned to either the experimental group (n=30) or the control group (n=30) reporting to the endoscopy unit of the clinic between may 2019 and october 2019. the study results were evaluated using an information form, a catheter insertion form, and a visual analog scale (vas). in the experimental group, black pepper essential oil was used to increase vein degree before the procedure, while in the control group, no extra interventions were applied. the time taken in determining an appropriate vein, time taken for successful catheter insertion, and the patient's and nurse's satisfaction after the process were recorded via a chronometer.

Eligibility criteria:
inclusion criteria: must be evaluable their veins as 1, 2 and 3 according to vein assessment scale must be able to communicate exclusion criteria: clinical diagnosis of peripheral vascular disease clinical diagnosis of any other chronic illness (except cancer)

Keywords: essential oil application catheter insertion
impact of ipt with sulfadoxin pyrimetamin on pregnant women and their babies outcomes in peri-urban areas of bobo-dioulasso(burkina faso)

Conditions: Malaria, Pregnancy

Summary: the purpose of this is to determine the impact of intermittent preventive treatment (ipt) with sulfadoxine-pyrimethamine (sp) on the morbidities associated with malaria in pregnant women and newborns in rural peri-urban areas of bobo-dioulasso, 5 years after its implemented.

malaria in pregnant women is a crucial issue in burkina faso. faced with this problem, a strategy based on the use of treated nets and intermittent preventive treatment (ipt) based on sulfadoxine-pyrimethamine (sp) was adopted in 2005. five years after its implementation, the investigators will check whether this strategy is still effective in the preventing maternal and congenital malaria on the one hand and maternal anemia, low birth weight and prematurity on the other hand.

Eligibility criteria:
inclusion criteria: * residing in the health area of lafiabougou or secteur 24 * having agreed to give free and informed consent exclusion criteria: * bleeding from during the pregnancy * eclampsia

Keywords: intermittent preventive treatment with sulfadoxin-pyrimethamine in bobo-dioulasso peri-urban areas, 5 years after its implementation burkina faso.
prolonged continuous ecg monitoring prior to transcatheter aortic valve implantation

Conditions: Aortic Valve Stenosis; Arrythmia

Summary: patients with severe aortic stenosis candidates for a tavi procedure harbor a high burden of silent arrhythmic events. pre-procedural detection of such arrhythmias should help the investigators to implement specific therapeutic measures that may improve patient outcomes and reduce hospitalization length post-tavi.

this is a prospective registry including patients accepted by the heart team for a tavi procedure. patients will undergo a prolonged continuous ecg monitoring using the cardiostat® device within the 3 months prior to the tavi procedure. the duration of the ecg monitoring will be of 1 week. there will be no restriction regarding the type of valve and approach used for the tavi procedure. all type of arrhythmic events will be recorded, as well as the specific therapeutic measures implemented upon the occurrence of the arrhythmic event. following the tavi procedure, the patients will be monitored (telemetry) until hospital discharge. all arrhythmic events during the hospitalization period will be recorded. clinical follow-up will be performed at 30 days, and 1 year post-tavi, and yearly thereafter up to 5-year follow-up.

Eligibility criteria:
inclusion criteria: * patients with severe aortic stenosis accepted for a tavi procedure by the heart team. exclusion criteria: * urgent tavi procedure or logistic reasons precluding an ecg monitoring of at least 1 week within the 3 months prior to the tavi procedure. * prior permanent pacemaker.

Keywords: tavi ecg monitoring