Kornimate/medical-research-clean huggingface dataset:
scalable communication modalities for returning genetic research results

Conditions: Hereditary Breast and Ovarian Cancer; Lynch Syndrome

Summary: efforts to examine the utility of alternate modalities for genetic results disclosure has widespread implications for how precision medicine research might yield direct health benefits for study participants. this study will examine the efficacy of an online self-guided program to return genetic results to a racial minority cohort population. study results will provide empirical evidence on the effectiveness of alternate modalities for genetic results return, inform ongoing efforts to establish scalable approaches for effective return of genetic research results, and increase access to personal health information among african american women.

this study is a randomized controlled trial (rct) within the black women's health study (bwhs) to test alternate communication modalities for results disclosure. the bwhs is an ongoing prospective cohort study of 59,000 self-identified black women from across the united states who have been followed since 1995. targeted sequencing of over 4000 women within the cohort for brca1/2 and other known or suspected high and moderate penetrance genes opens up the possibility of returning breast cancer genetic results to bwhs participants and examining the clinical utility of genetic results return. the primary aim of the proposed research project is to compare the efficacy of two communication modalities for returning breast cancer genetic research results to african american women: 1) a conventional modality that entails telephone disclosure by a licensed genetic counselor, and 2) an online self-guided modality that entails returning results directly to participants, with optional genetic counselor follow-up via telephone. secondary aims of this study will examine 1) moderators of the intervention impact and 2) psychosocial, sociodemographic, and clinical predictors of result uptake. this study is uniquely situated to provide critical empirical evidence on the effectiveness of alternate models for genetic results return and provide further insight into the factors influencing uptake of genetic information among african american women.

Eligibility criteria:
inclusion criteria: -women in the bwhs previously included in the targeted breast cancer sequencing project exclusion criteria: * women with known cognitive impairments * women with variant of uncertain significance (vus) results from the sequencing study

Keywords: brca testing return of genetic research results ehealth digital health risk communication elsi
the impact of frailty in type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of our work; to investigate the effect of frailty on balance and fall risk in individuals with type 2 diabetes.the reason why participants the investigators invited to the study is participants diagnosis of type 2 diabetes.during the research, a questionnaire form (age, gender, educational status, etc.) in which participants demographic information will be recorded for evaluation purposes and a consent form for participation in the study will be filled. standardized mini mental test will be applied. then fragility will be evaluated with the fried fragility index. fall assessment will be assessed with the fall risk self-assessment scale and balance assessment will be made with the tinetti balance. participants will not need to spend a long time for all assessments. the time required for the assessment will be around 30 minutes.


Eligibility criteria:
inclusion criteria: * diagnosed with diabetes * being 65 years or older * not having a cooperation problem, * no communication difficulties or problems voluntarily accepting participation in the research exclusion criteria: * - those with uncontrollable hypertension, heart disease, cardiac arrhythmia * those with cardiovascular disease * those who have malignancy and cause malignancy, chemotherapy, radiotherapy * those with any neurological or orthopedic disorders * those who have had an operation in the last 6 months * those on bed rest * individuals addicted to alcohol and drugs * those who do not agree to participate in the research
detection and treatment of depression in patients admitted to the general hospital

Conditions: Depressive Disorder; Depression

Summary: depression is a common disorder among patients with a somatic illness admitted to the general hospital. patients with depression do worse in terms of their somatic symptoms or functioning that those without depression. they also stay in the hospital for longer. that is the reason that we are interested to know whether patients with depression do better if their depression is recognised earlier and treated appropriately. we would like to find out which questionnaires are most suitable in clinical practice to help pick up patients with a depression. in addition, we would like to know whether a short-term psychological treatment of depression would be of any help. we hope to be able to show that this treatment would not only result in a reduction of depressive symptoms, but also in a better and quicker recovery of the somatic illness. the treatment will consist of 6 to 9 weekly sessions of one hour, conducted by a cognitive behavioural assistant. initially, the treatment will take place in the hospital. when patients are discharged, treatment sessions will continue at home. the treatment will focus on things like recognising and challenging unhelpful thoughts, planning of activities, and testing out of predictions by setting up behavioural experiments. three monthly booster sessions will be offered to help patients to maintain their gains and prevent relapse. we will reassess the symptoms of the patients at three and six months after the end of treatment.


Eligibility criteria:
inclusion criteria: * depressive disorder exclusion criteria: * severe physical disfunction * severe cognitive disfunction * speech and/or hearing disorder * limited knowledge of the dutch language

Keywords: intervention studies randomized controlled trials cognitive therapy hospitals, general prevalence
dose-guided radiotherapy in oesophageal cancer: managing the real dose

Conditions: Adenocarcinoma

Summary: this study will prospectively collect patients undergoing the standard cross regimen in the neoadjuvant setting of the treatment for gastro-oesophageal cancer. the investigators will focus on the potential geometric differences between the oar and target volume on the initial planning ct and on the kilovolt (kv) cone-beam computed tomography (cbct). they expect a potential difference in the abdominal part of the planned target volume (ptv) and/or gastro-oesophageal junction part. furthermore, the impact of gastric filling , potential tumor regression and the accuracy of 5 mm ptv margin in the thoracic ptv will be monitored.

optimal radiotherapy planning and delivery is essential for irradiation of gastro-oesophageal junction tumors. there is a need for individualized radiotherapy delivery to the upper abdomen, because of mobility. likewise, controlling gastric filling by instructing patients about fluid and food intake before treatment, may contribute to positional reproducibility. there is evidence that missing microscopic disease in treating the clinical target volume (ctv) results in a worse prognostic outcome. the investigators want to evaluate wether positional difference of stomach, with and without fasting prescription, has an impact of the delivered dose. they will focus on the part of the ctv extending in the stomach. the investigators hypothesize that measurement of the dose using verification kilovoltage cone beam cts will provide information on potential cold/hot spots of dose delivery and monitor potential geometric differences during treatment. this may result in a suboptimal treatment and a reconsideration of matching target volume on soft tissue instead of bony landmarks. the investigators will evaluate the first clinical results with dgrt in patients with esophageal cancer.

Eligibility criteria:
inclusion criteria: * histologically proven adenocarcinoma of the gastro-oesophageal junction * age 18 years or older * international union against cancer (uicc) t2-4 n0-2 m0, potentially resectable disease treated by the cross regimen * who 0-2 exclusion criteria: * thoracic adenocarcinoma/squamous cell carcinoma * palliative treatment for the oesophageal cancer
the captain trial: cerebrolysin asian pacific trial in acute brain injury and neurorecovery

Conditions: Traumatic Brain Injury

Summary: the purpose of this trial is to investigate safety and efficacy of cerebrolysin as add-on therapy to standard care in patients with acute traumatic brain injury (tbi). the study duration for each patient is 180 days.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of tbi and a gcs 7-12 * only isolated tbi * ct * pre-trauma karnofsky-index = 100 * age 18-60 years * male and female patients * time to needle for study medication within 6 hours after injury * patient is not pregnant or lactating during the trial and is not of childbearing potential * patient was able to speak, read and write in a pre-defined study language before the accident. * reasonable expectation of completion of outcome measures at follow-up * written informed consent exclusion criteria: * evidence of pre-existing major health problems * any neurological or non-neurological condition independent from tbi that might influence the functional outcome or other efficacy outcome measures * injury of writing hand influencing cognitive or other outcome measures * clear clinical signs of intoxication influencing the evaluation * major drug dependency including alcohol * chronic treatment with steroids, ca2+-channel blockers or major anticoagulants * penetrating high-velocity missile head trauma * stab wound trauma into the brain * patients with spinal cord injury
exercise and dry needling treatment combination in nocturnal calf cramps

Conditions: Nocturnal Leg Cramps; Myofascial Pain Syndrome

Summary: the investigators aim to evaluate the effectiveness of dry needling treatment in addition to stretching exercises on cramp duration, cramp intensity, cramp frequency, sleep quality, and sensitivity of myofascial trigger points in patients with nocturnal calf cramp.

nocturnal leg cramps are sudden, involuntary, painful contractions of the lower extremity in the nighttime, most often in the calf muscles, that gradually lessens. its etiology is not clear. it can be seen in electrolyte disturbances, drug side effects, neuromuscular diseases, diabetes mellitus, peripheral vascular pathologies. it has been mentioned in the literature that myofascial trigger points in the gastrocnemius muscle may be associated with nocturnal calf cramps. our aim in this study is to evaluate the effectiveness of the combination of stretching exercises and dry needling therapy on cramp duration, cramp intensity, cramp frequency, sleep quality, and algometer measurement in patients with nocturnal calf cramps and whose had myofascial trigger point in the gastrocnemius muscle.

Eligibility criteria:
inclusion criteria: * patients with only nocturnal calf cramp * patients with a trigger point in the unilateral gastrocnemius muscle * being between the ages of 18-50 exclusion criteria: * patients using diuretics or hypertension medications that may trigger cramping * those with a chronic disease history * those diagnosed with spinal stenosis * electrolyte disturbance in laboratory tests

Keywords: dry needling calf cramp myofascial trigger point
evaluation of the impact of sleep apnea on cerebral volumetry according to age

Conditions: Obstructive Sleep Apnea (SAOS); Aging

Summary: sleep apnea is a common disease in the general population and more particularly in elderly subjects in whom prevalence can reach 30 % after 70 years old. in adults (\ 70 years old) apneic subjects are less symptomatic in terms of sleepiness, they usually present a lower index of respiratory events and cardiovascular consequences in this population are still discussed, driving some authors to consider sleep apnea in the elderly as a specific disease and making the need for a treatment questionable. in this study the investigators will focus on the comparison between adult and elderly apneic subjects in terms of cognitive and cardiovascular consequences. adult apneic patients suffer from a decrease of cognitive performance as well as grey matter local atrophy, particularly in the hippocampus and in the frontal lobes. according to fewer studies, white matter can also be affected by a demyelinisation process. these structural modifications are sometimes associated with disorders of executive and memory functions. in the elderly, no clear association can be drawn between cognitive decline and sleep apnea. moreover, to our knowledge, the cerebral state of elderly symptomatic apneic subjects has mostly not be investigated.

the goal of this project is to evaluate the impact of sleep apnea on the brain according to age. our hypothesis is that adult apneic subjects would present local cerebral modification in the areas implied in cognition and memory, such as the hippocampus or the frontal areas, whereas elderly patients would present focal affects related to a deficit in the ventilatory and autonomic control without any major cognitive consequences. understanding the consequences of sleep apnea according to age could permit to refine the indications of sleep apnea treatment, mainly in elderly patients.

Eligibility criteria:
inclusion criteria for patients: * 18-55 or more than 70 years old * saos (ahi\>30) never treated before * consent form signed inclusion criteria for subjects: * 18-55 or more than 70 years old * no saos (ahi\<10) * consent form signed exclusion criteria (subjects and patients) : * contraindication in the practice of mri: pacemaker, metallic cardiac valve, intra-ocular metal part * contraindication in the injection of gadolinium (allergy during a previous radiological examination). * type 1 or 2 diabetes * history of cerebrovascular accident, myocardial infarction, congestive heart failure * chronic and/or severe renal insufficiency * chronic respiratory failure * neurological pathology * central origin sleep apnea (ahicentral \> 15)

Keywords: obstructive sleep apnea voxel-based morphometry polysomnography magnetic resonance imaging
stereotactic ablative radiotherapy (sabr) for treatment of ventricular tachycardia (vt) refractory standard invasive ablation techniques

Conditions: Tachycardia, Ventricular

Summary: the purpose of this study is to evaluate the clinical efficacy and safety of stereotactic ablative radiotherapy (sabr), also known as stereotactic body radiation therapy (sbrt), for treatment of ventricular tachycardia (vt) requiring implantable cardioverter defibrillator (icd) treatments in patients with vt refractory to standard invasive ablation techniques. we hypothesized that sabr is effective in suppressing sustained vt and reducing icd treatments in this group of patients and is associated with acceptably low risk of serious complications.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * have an icd implanted \> 6 months and all vt episodes in the past 6 months are available in device memory. * within the past 3 months, the patient has at least one episode of symptomatic monomorphic vt that requires icd treatment (anti-tachycardia pacing and/or icd shock) or was sustained/incessant but falls under icd treatment zone. these vt episodes must occur after at least one standard invasive vt ablation or occur in a patient that is clinically deemed not eligible to the standard vt ablation procedure. * two independent cardiac electrophysiologists reviewed the case and agreed that the patient would benefit from suppression of these vt episodes but there is no optimal invasive vt ablation or antiarrhythmic drug options. exclusion criteria: * has contraindication to receive sabr or vt clinically deemed not suitable for sabr. * is pregnant * has severe co-morbid medical condition or terminal illness and is unlikely to survive more than 6 months regardless of vt status based on clinical judgement by treating or enrolling physicians. * on potent immunosuppressive therapy (e.g., post organ transplant) * has severe collagen vascular disorder with organ involvement * not willing or not able to consent to participate in the study

Keywords: heart
impact of aromatherapy on nausea in hospitalized children undergoing rehabilitation

Conditions: Nausea

Summary: children, ages 8 - 17, will be enrolled in a research study about the impact of aromatherapy on nausea in the pediatric rehabilitation unit.

children will participate in the study for two weeks. one week the child will receive a aromatherapy product for nausea and the other week the child will not receive the product. if this aromatherapy is effective at decreasing nausea, the child may be more likely to participate in their rehabilitation therapy sessions. information gathered during the study may potentially benefit other patients by helping to develop hospital practices of using aromatherapy in the pediatric rehabilitation unit. children participating in the study may or may not help the child but may help children in the future: 1. children may have less nausea, which could help them feel better, more likely to participate in their rehabilitation activities, and may be able to take better care of themselves. 2. children may have a reduction in the need for taking medications that help nausea. 3. the research may benefit children in the future by helping to develop hospital practices about using aromatherapy in pediatric rehabilitation.

Eligibility criteria:
inclusion criteria: * patients ages 8 to 17 years of age on the rehabilitation unit and service at arkansas children's hospital * patients with a glascow coma scale (gcs) of 13-15 * patients with a rancho los amigos revised scale score of 5 or higher * ability to read and write in english * patient to have an expected length of stay of at least 2 weeks exclusion criteria: * patients with any mechanical or obstructive pathophysiology (appendicitis, bowel obstruction, or intussusception, etc.) * known allergy or sensitivity to lavender, peppermint, spearmint, or ginger * patients with known asthma and/or pulmonary conditions * wards of the state or any other agency or institution

Keywords: kids nausea aromatherapy rehabilitation
association between blood pressure and risk of psci

Conditions: Stroke; Cognitive Decline; Blood Pressure

Summary: this retrospective cohort study was designed to explore the relationship between blood pressure and cognitive impairment after stroke

patients who have been followed up for more than 3 months after stroke will be included in the study. basic data of patients and factors that may be related to cognitive impairment will be collected, and the relationship between blood pressure and cognitive impairment after stroke will be explored by univariate regression analysis and multivariate regression analysis. univariate logistic regression model and multivariate logistic regression model were used to explore the relationship between blood pressure level and the risk of cognitive impairment after stroke, and the effect of blood pressure level and cognitive impairment sub-line in different patients was evaluated by subgroup analysis.

Eligibility criteria:
inclusion criteria: 1. patient diagnosed with stroke by ct or mri, 2. patients completed the mmse scale at least once during hospitalization 3. the follow-up time was more than three months after the stroke occurred; exclusion criteria: 1. patients with incomplete data, follow-up time less than three months after the stroke occurred less than 3 months, 2. patients with pre-existing cognitive impairment before stroke according to their medical records, 3. patients failed to complete mmse assessment because of aphasia or any other reasons, 4. patients combined with malignant tumors, patients combined with psychiatric disorders.

Keywords: stroke cognitive impairment blood pressure
clinical study of peripheral capillary oxygen saturation (spo2): vital signs patch (vsp)

Conditions: Desaturation of Blood

Summary: a clinical study designed to determine the accuracy of the peripheral capillary oxygen saturation (spo2) function of the vital signs patch (vsp) device for measuring blood saturation level.

the clinical study protocol was designed for determining the accuracy of the spo2 function of the vital signs patch device for measuring blood oxygen saturation level, according to the guidelines for "evaluating and documenting spo2 accuracy in human subjects" as set out in annex ee of iso 80601-2-61. section 4.

Eligibility criteria:
inclusion criteria: * ages 23 to 33. * skin tone varied from light to dark. exclusion criteria: * smokers * anemic
retrospective trial on low prognosis infertile patients

Conditions: Infertility, Female; Fertility Disorders

Summary: the main objective of this study is to analyze management of controlled ovarian stimulation (cos) protocols in low prognosis patients, secondly to observe the clinical outcomes (fertilization rate, pregnancy rate, the ongoing pregnancy rate and the live birth rate) and the total units of gonadotrophins consume per m2 oocyte retrieved in this subgroup.

humanitas fertility center maintains an external audit anonymized electronic research queries system, exported from a certified only access web database, which at time of this analysis (cycles at december 31th 2016) include 26,883 consecutive fresh non-donors ivf cycles. patients who underwent these cycles had consented in writing that their medical records could be used for research purposes, as long as the patients' anonymity was protected and confidentiality of the medical record was assured. since both of these conditions were met, this study has been approved on march 2th 2017 with an expedited review and approval protocol by the center's institutional review board (irb). at least 2,000 expected low prognosis patients in the humanitas fertility center database out of 12,545 cycles performed in the period 2010-2015 with completed pregnancy follow-up.

Eligibility criteria:
inclusion criteria: * age ≤ 44 * body mass index; 18 ≤ bmi ≥ 27 * number of oocytes retrieved ≤ 9 * cycles performed between january 2010 - december 2015 exclusion criteria: * age \> 44 * number of oocytes retrieved ≥ 10 * abnormal uterine cavity * endometriosis iii-iv stage or adenomyosis * testicular spermatozoa pgs (preimplantation genetic screening) cycles

Keywords: low responders