Kornimate/medical-research-clean huggingface dataset:
efficacy of hydroxyzine for patients with panic disorder

Conditions: Panic Disorder

Summary: the aim of this study is to evaluate the efficacy of hydroxyzine compared to treatment as usual (tau) for patients with panic disorder. by conducting a pilot study, we hope to provide initial data on the feasibility and potential impact of hydroxyzine for this population. this will inform the design and power calculations of a larger, more comprehensive study in the future. objectives: to assess the feasibility of conducting a randomized controlled trial (rct) of hydroxyzine for panic disorder. to evaluate the effectiveness of hydroxyzine compared to tau in reducing panic symptoms in patients with panic disorder. to explore the potential side effects and tolerability of hydroxyzine in this population. methods: this will be a single-center, open-label, randomized pilot study. a total of 30 patients with a primary diagnosis of panic disorder will be recruited from a psychiatric outpatient clinic. participants will be randomly assigned to receive either hydroxyzine or tau for 8 weeks. the primary outcome measure will be the change in panic symptoms as assessed by the panic disorder severity scale (pdss). secondary outcome measures will include the hamilton anxiety rating scale (ham-a) and the clinical global impression-severity (cgi-s) scale. participants will be assessed at baseline, 4 weeks, and 8 weeks. adverse events will be monitored throughout the study. expected results: this pilot study is expected to provide preliminary data on the feasibility and potential efficacy of hydroxyzine for panic disorder. the results will inform the design of a larger rct to further evaluate the efficacy of hydroxyzine for this population. significance: there is a need for effective and well-tolerated treatments for panic disorder. if found to be effective, hydroxyzine could provide a new option for patients with this condition, potentially improving their quality of life and functioning. the results of this pilot study will inform the design of future studies and contribute to the development of evidence-based treatments for panic disorder.


Eligibility criteria:
inclusion criteria: * the study will recruit adult patients (18 years and older) * confirmed diagnosis of the panic disorder according to the diagnostic and statistical manual of mental disorders (dsm-5). * participants will be included if they have had at least one panic attack per week for the last four weeks, * have not received any pharmacological treatment for panic disorder in the past four weeks, * willing to discontinue any current benzodiazepine or ssri treatment for the duration of the study. exclusion criteria: * current substance abuse or dependence, * medical diseases * psychiatric comorbidities, * pregnancy or lactation.
health-related quality of life and psychosocial aspects of diabetes technology (insulin pumps)

Conditions: T1DM; Health Related Quality of Life; Insulin Pump

Summary: this study will be prospective comparative trial comparing between insulin pumps vs multiple daily injections (mdi) in treatment of type 1 diabetes mellitus (t1dm) in terms of health- related quality of life (hrql) and efficacy of glycemic control (hba1c level ) hypothesis: type 1 diabetes is characterized by autoimmune destruction of insulin-secreting pancreatic b cells leading to disturbed glucose regulation and overt hyperglycemia which leads to variable consequences and complication. consequently, individuals with type 1 diabetes have a lifelong dependency on insulin replacement therapy. aim of the work: to compare the psychosocial impact of insulin pumps versus multiple daily injections in treatment of type 1 diabetes mellitus (via questionnaire) in terms of health-related quality of life and efficacy of glycemic control (hba1c level).


Eligibility criteria:
inclusion criteria: * 1.type 1 diabetes mellitus. * 2.patients who are on insulin pumps must be for at least 3 months on them exclusion criteria: * 1. other types of dm e.g., t2dm, mody. * 2. patients with other comorbidities; cardiac, renal, neurological, hepatic ....etc.

Keywords: insulin pump t1dm hrql
radiologic assessment in complete mesocolic excision for right colon cancer (racomerc)

Conditions: Right-sided Colon Cancer

Summary: colorectal surgery has made progressive advances in recent years related on one hand to the implementation of diagnostic methods that allow an early diagnosis of tumors and on the other hand to the development of therapeutic options based on laparoscopic surgery. in particular, multicenter clinical trials have shown that the laparoscopic approach to colorectal cancer had a comparable or even better outcomes in terms of perioperative complications and functional recovery of patients than traditional surgery. complete mesocolic excision (cme) in right colonic resections is a surgical approach, of greater technical complexity, that appears to improve the oncological outcomes of these patients at the cost of an increased rate of complications. the highest rate of complications reported in the literature in patients undergoing cme was related to intraoperative bleeding due to the central vascular dissection that is performed. ct technological advances have made possible to perform ct angiography with multiplanar and three-dimensional reconstructions with the possibility of obtaining a detailed preoperative map of the vascular anatomy of these patients. ct scan was acquired immediately before contrast material injection and during arterial and venous phase. arterial phase was obtained using the bolus tracking technique with an automated scan-triggering software. image analysis was performed using multiplanar reformations (mpr), maximum intensity projection (mip) and 3d volume rendering (vr) technique. the purpose of the ct was to identify three different parameters necessary for proper performance of cme and cvl and to compare preoperative observations with intraoperative evidence. all surgeries were performed by teams experienced in laparoscopic colorectal surgery. the investigators evaluated:- fascia of fredet; vascular structures; lymph nodes.

x

Eligibility criteria:
inclusion criteria: * patients with diagnosis of right-sided colon cancer * patients underwent to ct angiography * laparoscopic right hemicolectomy with cme and cvl. exclusion criteria: * metastatic disease * palliative treatment * impossibility to perform ct angiography * patients underwent to a traditional colonic resection with d2 lymphadenectomy.

Keywords: right colon cancer complete mesocolic excision ct abdominal scan
increased blood glucose levels after steroid injection

Conditions: Osteoarthritis, Knee; Diabete Type 2

Summary: a sample of 600 patients diagnosed as knee osteoarthritis injected with 40 mg triamcinolone, recorded their morning fasting blood glucose levels for 7 days before injection used as the baseline blood glucose level, which was compared with fbs levels for 14 days after steroid injection. our study compared the differences in blood glucose changes between hba1c \>7% and hba1c ≤7% groups and those between insulin and non-insulin treated groups.


Eligibility criteria:
inclusion criteria: age \> 18 years, patients with knee osteoarthritis diagnosed according to american college of rheumatology (acr) criteria (17), and grade1-3 in kallgren-laurence radiographic scale (18), whom failed to response to medical treatment including paracetamol and nonsteroidal anti-inflammatory medication, and to physical therapy, checking their blood glucose values daily. exclusion criteria: patients who were unable to provide consent, patients had any contraindications to corticosteroids, patients who had received oral corticosteroid in the past 6 months or corticosteroid injection in the previous 3 months, patients who had no monitoring hba1c level before injection or also whom had not monitor blood glucose levels before or after injection.
validation of ai lumbar spine anatomy measureing function

Conditions: Spinal Cord Compression

Summary: spinal degeneration and its associated clinical diseases are common ailments in aging societies. with the advent of a super-aging society, the importance of assistive technologies for spinal image interpretation is increasingly significant to enhance care efficiency and reduce medical personnel expenditure. recently, due to the rapid development of artificial intelligence (ai) algorithm, ai-based computer-assisted detection (cade) devices gradiually become a convenient method for spinal anatomy measurement. however, the accuracy of these devices has not been fully established. this study aims to validate the performance of radispine (an application program) in spinal anatomy segmentation and measurement.


Eligibility criteria:
inclusion criteria: the subjects should be aged 20 or older and younger than 75, with an equal gender distribution of 50% male and 50% female. from this group, 150 subjects with reasonable datavalues will be selected, with a requirement that at least 30% of them are male and at least 30% are female. exclusion criteria: 1. with history of spinal surgery 2. spinal trauma 3. spinal osteoporosis 4. spinal metastasis or infection

Keywords: artificial intelligence(ai) algorithm spinal anatomy
efficacy and safety evaluation of vi-sealer

Conditions: Benign Gynecologic Neoplasm

Summary: this study's primary goal is to compare the efficacy and safety of the novel advanced hemostatic device(ahd), vi-sealer, with conventional ahds in laparoscopic total hysterectomy for patients with benign gynecologic neoplasm.

vi-sealer is a reusable advanced bipolar electrode with an interchangeable blade. this study evaluates the efficacy and safety of the vi-sealer by comparing it with other advanced hemostatic devices, such as ligasure, enseal, thunderbeat, harmonic scalpel, etc. the economic evaluation of the device compared with other disposable devices would also be conducted.

Eligibility criteria:
inclusion criteria: 1. aged 20 to 65 years 2. clinically diagnosed with benign gynecologic neoplasms (eg. adenomyosis, uterine fibroids, etc.) 3. eligible for hysterectomy 4. signing an written consent form indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study prior to any other study-related assessments or procedure exclusion criteria: 1. large uterus size over 16 weeks of gestational age 2. cervical or intraligamentary fibroids 3. severe endometriosis (stage 3 or 4) 4. suspected malignancy of the uterus or adnexa 5. contraindicated for the use of energy devices (such as implantable cardioverter defibrillators, pacemakers) 6. previous pelvic surgery ≥ 3 times 7. not suitable for laparoscopic surgery

Keywords: advanced hemostatic devices advanced energy devices ligasure laparoscopic total hysterectomy vi-sealer
nutritional intake and gut microbiome

Conditions: Obesity, Childhood

Summary: pediatric obesity has been increasing in prevalence, but concerns have been raised around the world because no treatment has been found. recently, however, research on gut microbiome has begun to become a new alternative. it has been shown that changes in the microbiome in adults may induce obesity. however, the results on children are still scarce. unlike adults, children have few external factors such as alcohol, tobacco, stress, and cancer, making them suitable for obesity-related gut microbiome studies. the investigators will use illumina miseq platform for 16s rrna metagenomics profiling in children. in this study, the investigators aimed to analyze the relationship between pediatric obesity, gut microbiome profile, blood biomarkers relevant to metabolic syndrome, and nutrient intake data.


Eligibility criteria:
inclusion criteria: * obese children: children ≥95 ‰ between age 7 and 12 years * non-obese children: 5‰\<bmi \<85 ‰ for children between the ages of 7 and 12 years exclusion criteria: * taking antibiotics, probiotics, or steroids for a month before visit * taking probiotics-like products including yogurt for seven days before visit * having enteritis symptoms including diarrhea for a month before visit * chronic heart disease, chronic bowel disease, chronic liver disease, chronic kidney disease, endocrine disease, genetic diseases or congenital metabolic disorder

Keywords: microbiome gut
neothyr - the role of mitochondria-dysfunction in newborns of mothers with autoimmune thyroid disease

Conditions: Subclinical Hypothyroidism; Autoimmune Thyroid Disease; Alteration of Mitochondrial Membrane

Summary: previously, studies have shown that children of women with thyroid autoantibodies experience more birth complications and poorer health in their first days. studies have also shown later signs of cognitive developmental challenges (risk of attention deficit/hyperactivity problems) among children of mothers with autoimmune thyroid disease and/or subclinical hypothyroidism. in denmark there is no formalized screening or treatment of subclinical thyroid disease - with or without thyroid peroxidase antibodies (tpo-antibodies) - among pregnant women. the hypothesis of this study is that the offspring of women with subclinical thyroid disease have a mitochondria-dysfunction which leads to more complications during birth, poorer health and well-being in the early childhood. the investigators will test this by recruiting mothers by a blood sample in the third trimester of pregnancy, screen the cord blood at birth and later on test the children with bayley test two times in the early childhood.

prior to a planned caesarean section, maternal blood samples are drawn and at the cesarean, cord blood samples are drawn, when the cord is clamped and cut. thyrotropin, free t3, free t4, anti-tpo and lipids are measured on maternal as well as cord samples. flow cytometry is performed to measure mitochondrial function. at age 6 months and 15 months the child´s development is evaluated by the bayley-iii test.

Eligibility criteria:
inclusion criteria: * singleton pregnancy, clinically healthy exclusion criteria: * twin-pregnancy, metabolic disorder, medication or other diseases with a potential adverse impact on the pregnancy and fetus

Keywords: mitochondria function tpo-antibodies subclinical thyroid disease thyroid disease in pregnancy children´s development
pet scans in normal volunteers and patients with fabry disease

Conditions: Fabry Disease; Healthy

Summary: this study will determine the rate of sugar metabolism in the brain of patients with fabry disease, a genetic disease of abnormal lipid metabolism. compared with healthy people, patients with fabry disease have increased blood flow to the brain, which may result from abnormal brain metabolic activity. this study will use positron emission tomography (pet) and magnetic resonance imaging (mri) to compare brain sugar metabolism in eight untreated patients, eight patients who are receiving enzyme replacement therapy, and eight healthy volunteers. patients with treated and untreated fabry disease and normal volunteers may be eligible for this study. participants will undergo the following two procedures: 1. pet scan \< the patient lies in the pet scanning machine. first, the chest is scanned for a few minutes to determine how much radiation the tissues of the chest absorb. a radioactive sugar called fluorodeoxyglucose (fdg) is then injected through a catheter (thin plastic tube placed in a vein) and the heart is scanned for about 45 minutes to measure the amount of fdg in the blood inside the heart. the head is then scanned for about 20 minutes to measure fdg in the brain. this measurement tells how much sugar the brain uses for energy. the procedure requires insertion of two or three catheters. a special facemask may be molded to the patient's head to help hold the head still during the scanning. 2. mri scan \< the patient lies on a table surrounded by the scanner (a metal cylinder) for about 60 minutes. a strong magnetic field and radio waves are used to show images of structural and chemical changes in tissues. this study may provide information that will help explain abnormalities in fabry disease and the effect of treatment on the brain.

we have found that patients with fabry disease have an increased resting global cerebral blood flow compared with healthy subjects. this augmentation may result from an abnormal metabolic activity in the brain of the patients. the goal of this protocol is to study the cerebral metabolic rate of glucose (rcmrglu) in eight untreated patients with fabry disease, eight fabry patients who are receiving enzyme replacement therapy and compare it with the rcmrglu eight in healthy volunteers. in order to minimize the need for arterial lines we shall image the left ventricle of the heart to obtain the (18)fdg time-activity curve needed to measure rcmrglu. the method will be validated in the healthy volunteers.

Eligibility criteria:
hemizygote male fabry patients 18-50 years-of-age. must be able to tolerate the procedures. must be able to give written informed consent.

Keywords: blood flow glucose lysosomal disease metabolic uptake fabry disease
brentuximab vedotin combined with bendamustine supercharge, a low-toxicity and efficient salvage regimen for primary refractory or first-relapsed classic hodgkin lymphoma: long-term results of a retrospective monocenter study.

Conditions: Hodgkin Lymphoma

Summary: this is a retrospective, monocenter and non-interventional study. data were retrospectively collected from all patients who completed the bv-bs scheme in the time period between 1 september 2013 and 1 september 2023.

this is a retrospective, monocenter and non-interventional study. data were retrospectively collected from all patients who completed the bv-bs scheme in the time period between 1 september 2013 and 1 september 2023. the regimen consisted of 3-day outpatient intravenous infusions of 1.8 mg/kg bv on day 1 of each 3-week cycle (as established by younes and colleagues) sequentially combined with bendamustine (at least 24 hours after bv, precisely on days 2 and 3 of the treatment cycle; as reported by picardi et al) at a fixed dose of 120 mg/m2 per day. all patients who achieved at least partial remission were considered eligible for peripheral blood stem cell (pbsc) collection (performed with granulocyte colony-stimulating factor \[g-csf\] and endoxan or plerixafor, if necessary) and proceeded to asct at any time beyond cycle 4. the anti-tumor activity of this treatment regimen was assessed according to the lugano criteria at the end of the combination treatment. prior to the first cycle of bv-bs, all patients underwent a clinical evaluation that included assessment of b symptoms, world health organization performance status, and measurement of palpable lesions. in particular, imaging procedures were conducted after the second and fourth cycles or prior to asct. the response was based on international criteria (cheson et al, 2016). pet scans were considered positive or negative based on the deauville 5-point scale criteria.

Eligibility criteria:
inclusion criteria: * patients age between 18 years and 60 years; * histological confirmation of cd30+ subtype chl at first relapse or at refractory (patients who have failed to achieve complete remission at the end of treatment with 4-6 cycles of abvd or who have progressed early during front-line treatment \[after 2 cycles of abvd\] with interim fdg-pet/ct with deauville scale score of 5 \[primary refractory patients\]) * treatment with at least 1 cycle of bs and bv at doses of 120 mg/m2 and 1.8 mg/kg, respectively * metabolically active disease measurable at fluoro-desossi-glucose-positron emission tomography/computed tomography (fdg-pet/ct) * egog performance status 0-2 (or 3, if due to illness). exclusion criteria: * patients not fulfilling inclusion criteria

Keywords: hodgkin lymphoma primary refractory bendamustine supercharge brentuximab vedotin
the correlation between the metabolism and the functional status of multiple organs in the early stage of diquat poisoning

Conditions: Diquat Poisoning

Summary: diquat (dq), as a conductive biocidal herbicide, is classified as medium according to chinese pesticide toxicity classification standards. since the sale and use of paraquat are stopped in 2016, incidents of diquat poisoning have begun to increase. diquat is very toxic to the human body. mistake of diquat can cause damage to multiple organs throughout the body. it has a high fatality rate and no specific treatment.the treatment method has become a research hotspot of modern poisoning treatment. the degree of organ dysfunction caused by dq poisoning is mainly related to the patient's intake and the distribution of the poison in the human body.so far, the distribution concentration of dq under the influence of the time gradient in the body and the influence of dq on the human environment，metabolimics,，immune regulation activity and the comprehensive mechanism of action of various inflammatory factors have not been fully elucidated. therefore, this research mainly focuses on analyzing the internal environment metabolism research in patients with dq poisoning, and to conduct exploratory research on the severity of the impact on their organ functions


Eligibility criteria:
inclusion criteria: 1.time from poisoning to hospital admission: within 6 hours, 2 the age is greater than 18 years old, less than 65 years old 3 there is at least one target organ dysfunction 4 previous physical fitness 5 no bad habits (drug use, alcohol addiction) exclusion criteria: 1. refuse to join this study 2. missing/incomplete information 3. pregnant women, vulnerable groups such as those who have no capacity for civil conduct and cannot determine the consent of their attorneys 4. chronic organ dysfunction (chronic heart insufficiency, chronic respiratory insufficiency, chronic renal insufficiency, chronic liver insufficiency) 5. tumors, blood system diseases, various systemic immune diseases 6. various infectious diseases (various hepatitis, tuberculosis, aids)

Keywords: diquat metabolomics toxicology multicenter
cost-efficacy of silver diammine fluoride in erupting molars

Conditions: Dental Caries

Summary: this study aims to evaluate the cost-effectiveness of 30% silver diammine fluoride in the treatment of clinically caries lesions in enamel, on occlusal surfaces in first permanent molars compared to a control group that performs only the cross-toothbrushing technique and evaluate the acceptability and satisfaction of patients and responsible for the application of the solution cariostatic.

the sample will be comprised of 183 patients between 4 to 7 year-old, who present at least occlusal surface with initial caries lesion (icdas 1, 2, 3). patients will be randomly allocated to treatments, according to the technique to be employed: (i) 30% diamine silver fluoride, (ii) cross-toothbrushing technique. will also be guided and motivated individual, where these children will be taught the technique of brushing conventional. it will be given to all patients a toothbrush. in times of reassessment, the degree of wear of the bristles of these brushes will be evaluated in order to infer the use of the same. the teeth will be evaluated by clinical and exams at baseline and after 3, 6, 12, 18 and 24 months.

Eligibility criteria:
inclusion criteria: * erupting permanent molars (that are not in full occlusion) * not special children * children who present at least occlusal surface with initial caries lesion (icdas 1, 2, 3) exclusion criteria: * presence of cavitated caries lesions * presence of enamel defects (hypoplasias)

Keywords: dental caries permanent teeth silver diamine fluoride tooth eruption