Kornimate/medical-research-clean huggingface dataset:
telementoring for emergency ultrasonography performed by emergency physicians with low experience.

Conditions: Teleradiology, Ultrasonography

Summary: 1. purpose * this study aims to evaluate the feasibility of iphone based telementoring for the ultrasonography. 2. methods * study design: prospective observational study * study setting: urban academic ed of tertiary care teaching hospital * study period: july, 2014 \~ december, 2014 (six months) * study participants: of the patients who need to undergo ultrasonography in the ed, those who are agreed to participate in this study are enrolled. 3. we hypothesize that the iphone based real time tele-diagnosis by remote expert would not be different from the diagnosis via his/her direct ultrasound examination.

* teleultrasound system 1. we already developed the telesystem for viewing the ultrasound examinations performed in the emergency department (ed) by using the iphone display simultaneously at the out of ed. 2. remote mentors can view the patient and examiner's hand holding the ultrasound probe while simultaneously viewing the ultrasound image in the same field of ultrasound display 3. the examiner and the mentor can communicate with each other. * procedures: 1. the residents perform the ultrasonography and the out of ed expert observe the practice by using the iphone. 2. while viewing the practice, the mentor can guide the examiner (resident) to manipulate the probe to get the best ultrasound image. 3. after finishing the practice, the mentor measures the speed of used mobile network using the application of 'benchbee' and records the predesigned registry. 4. the registry includes the patients' information, the time and date of examination, the type of mobile network (3g, lte, wifi and etc.) and the speed of mobile network, used tele-displayer (iphone, ipad, ipad mini), used probe, performed body organ (cardiac, lung, hepatobiliary, vascular, genital organ, appendix and intestine including suspected intussusception), the examiner's level of training and the ultrasound experience of the examiner and the mentor. 5. the mentor records the patient's diagnosis and the problems during this procedure. 6. the mentor goes to the patient, perform the ultrasonography directly and confirm the patients' diagnosis. 7. we will investigate the diagnostic accuracy for iphone-based tele-ultrasonography comparing these diagnoses.

Eligibility criteria:
inclusion criteria: * the patients who undergo the emergency physician-performed ultrasonography exclusion criteria: * the failure of examination due to such as patients' severe obesity, a large amount of gas and etc. * the patients who refuse to participate in this study. * the patients who need emergency ultrasonography.

Keywords: real time, ultrasonography, handheld
drinking extra water for to prevent or decrease headaches

Conditions: Headache

Summary: the purpose of this study is to find out if drinking extra water helps people prevent or relieve headaches and hunger and, if so, what volume of water is most effective and when is it best to drink it?

if participants decide to participate in this trial, they will be asked to drink a specific amount of water at particular times of the day for 14 days. a computer will decide by chance the amount of water they will be asked to drink each day of the trial and the times at which to drink this. there are different amounts and different times that people will be asked to drink water, this is so that the investigators can find out if there is an optimal volume of water to drink, and a best time to drink water to reduce headaches or hunger. the least amount of water the computer could ask participants to drink is half a glass (that is 4oz or 120ml). the largest volume of water the computer could ask participants to drink would be eight glasses of water a day (a total of 64oz or 2l) spread across the day (that is not all at once). once the computer has assigned participants to a particular volume and times to drink water, these will remain the same for every day throughout the study. participants will be asked to provide some brief information about themselves at the beginning of the study (for example, age, sex, height and whether you exercise, smoke or not). during the study they will be asked to weigh themselves and record this, their dietary habits and the amount they drink will be kept on a private and confidential page on the study website. they will be asked to fill in \[2\] confidential short surveys about how they feel and their views, one at the start and one at the end of the study.

Eligibility criteria:
inclusion criteria * any adult (defined as someone aged 18 or above) for whom advice to drink extra water is not contraindicated. exclusion criteria general exclusions * \< 18 years of age * no personal email address * pregnancy * ecstasy recreational drug use exclusions health conditions * impaired renal function * chronic bowel problems * low sodium levels * diabetes insipidus * schizophrenia or history of psychosis * anorexia or bulimia * congestive heart failure * current chemotherapy treatment exclusions concurrent medications * taking regular non-steroidal anti-inflammatory drugs * diuretics (e.g. thiazides, indapamide, loop diuretics), also called "water tablets" * anti-depressants: selective serotonin re-uptake inhibitors (ssris), tricyclic and tetracyclic antidepressants (tcas),monoamine oxidase inhibitor (maois) * anti-psychotics (e.g. haloperidol) * anti-convulsants (e.g. sodium valproate, carbamazepine) * cancer drugs (anti-neoplastic agents) implicit exclusions * people without internet access * people who cannot read * people without the ability to understand the website and informed consent documents

Keywords: headache hunger intensity public led online trial water intake
utility of high flow nasal cannula in co toxicity

Conditions: Carbon Monoxide Poisoning; Environmental Exposure

Summary: determination of the half-life of cohb in co-poisoned patients with high flow nasal oxygen therapy in the ed.

carbon monoxide (co) poisoning is common and potentially fatal environmental emergency which requires immediate attention. it is responsible for up to 40,000 emergency department (ed) visits and 5000 to 6000 deaths per year, making it one of the leading causes of poisoning death in the united states. the management options for co poisoning are limited to high flow oxygen by face mask or hyperbaric oxygen treatment. while half-life of carboxyhemoglobin (cohb) in a patient treating with high flow oxygen via a nonbreathing face mask is 90 minutes, it becomes 30 minutes with hyperbaric oxygen treatment (hbo). the hypothesis of this study is using high flow nasal oxygen therapy in the co poisoning may be more effective and safer treatment method comparing to standard oxygen therapy in the ed. also, it may be a safe promising alternative of hyperbaric oxygen therapy. the aim of the study is to determine the half-life of cohb in co-poisoned patients with high flow nasal oxygen therapy in the ed.

Eligibility criteria:
inclusion criteria: * the patients who are admitted to the emergency department with co poisoning with a cohb level of \>10%. * the patients who accept to participate in the study. exclusion criteria: * the patients who are \<18 years old. * the patients who need mechanical ventilation * the patients who are implemented oxygen more than 30 minutes before the ed admission * the patients who will be transferred to the hyperbaric oxygen center before the cohb levels are decreased to the half.

Keywords: carbon monoxide toxicity high flow nasal cannula emergency department
fdg-pet as an imaging modality to diagnose and risk stratify subclinical, imaging negative ici-myocarditis

Conditions: Subclinical Immune Checkpoint Inhibitor-Induced Myocarditis; Myocarditis; ICI-Myocarditis; Solid Malignant Tumor; Hematologic Malignancy; Subclinical Myocarditis; Subclinical ICI-myocarditis

Summary: the purpose of this pilot study is to evaluate fluorodeoxyglucose - positron emission tomography (fdg-pet) as an imaging modality to diagnose and risk stratify subclinical, imaging negative ici-myocarditis, and to determine whether subclinical ici-induced myocarditis is a distinct and clinically relevant entity with a risk of progression to fulminant myocarditis.


Eligibility criteria:
inclusion criteria: * age ≥18 years at the time of signing informed consent * any solid or hematologic malignancy undergoing treatment with ici (either as a single agent or in combination with others) * ambulatory and able to complete a 48-72 hour high fat and low carbohydrate diet with 18 hours fasting (pet diet), 18f-fdg pet/ct scanning, as well as 13n-ammonia pet-ct myocardial perfusion imaging (part of the routine protocol of the investigation). these two studies will be done as part of the same imaging set. * willing to return to mayo clinic for ongoing follow-up * left ventricular ejection fraction (lvef) ≥45% * cardiac mri (cmr) without conclusive evidence of inflammation, coronary assessment available (either via cardiac computed tomography angiography, ccta, or via coronary angiogram) informed consent obtained before any trial-related activities. trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial. exclusion criteria: * fulminant myocarditis requiring steroid therapy * cmr with definitive evidence of myocarditis * clinical presentation consistent with acute coronary syndrome (wall motion abnormalities consistent with a specific coronary distribution, coronary angiogram with a culprit lesion identified, patients requiring revascularization either with percutaneous coronary interventions or coronary artery bypass grafting). * patients unable to provide informed consent * patients unable to complete the diet preparation protocol * pregnancy (all women of child-bearing age and potential will have a negative pregnancy test within 48 hours of the pet/ct at screen and 6-month visit) * breastfeeding
tlc d-99 and ifosfamide in metastatic soft tissue sarcoma patients

Conditions: Sarcoma, Soft Tissue

Summary: the purpose of this study is to determine the maximum tolerated dose of the tlc d-99 combined with ifosfamide and then the efficacy of this combination in terms of overall response rate, time to progression and time of response

the maximum tolerated dose of the combination was determined and the phase i terminated. then, phase ii study started.

Eligibility criteria:
inclusion criteria: * histologic diagnosis of soft tissue sarcoma metastatic or recurrent after 6 months from the last chemotherapy * age \>/=18 yrs * ps \</=2 * disease detectable almost for 1 dimension * life expectancy \>/=3 mos * minimum 4 wks from last radiotherapy * adequate medullary, liver, and renal functions * normal lvef * written informed consent exclusion criteria: * pregnant or breast-feeding patients * serious concomitant disease or not controlled infections
perioperative complications in reversed shoulder arthroplasties

Conditions: Proximal Humeral Fracture

Summary: retrospective observational study of reversed shoulder arthroplasties by proximal humeral fracture. analysis of preoperative risk factors as well as minor and major complications at the first week, 90 days and 1 year.

the study is a multicenter retrospective observational study (3 centers). data are collected from 105 patients over 65 years-old undergoing reversed shoulder arthroplasties by proximal humerus fractures, in 3 or 4 parts. patient information is obtained from the clinical records in their usual preoperative assessment, and follow-up on the usual routine checks, at the first week, 90 days and 1 year. minor and major complications rates are evaluated according to preoperative risk (asa), underlying diseases and according to anticoagulant / antiaggregant treatments. likewise, transfusion rates related to asa, as well as length of hospital stay related to it.

Eligibility criteria:
inclusion criteria: * complex( 3- or 4-part) humerus fractures undergoing reversed shoulder arthroplasties. exclusion criteria: * no exclusion criteria

Keywords: reversed shoulder arthroplasties clinical complications complex proximal humeral fractures
movement system impairment based classification versus general exercise for chronic non-specific low back pain: a randomised controlled trial

Conditions: Low Back Pain

Summary: the objective of this study is to investigate the efficacy of a treatment based on movement system impairment based classification (msi) model in patients with chronic non-specific low back pain.

the subjects will be recruited from orthopedic outpatient clinics as well from the community. the examiner will screen the eligibility of each subject based on the eligibility criteria. all eligible subjects will receive information about the study and will sign an informed consent form before participating in the study. the examiner will collect the baseline data prior to randomisation. this examiner will be blinded to patients' allocation to treatment groups. the subjects will be randomly allocated to one of two groups (treatment based on msi model or general exercise) using a computer-generated randomisation schedule conducted by a study researcher who will not be involved with the patients and assessment of outcomes. participant allocation will be kept in a sealed opaque envelopes using a random numerical sequence. the examiner, responsible for the treatment will open the envelope in front of the patient and will communicate him about which treatment group he will be part of. the clinical outcomes of this study will be assessed before, after the treatment (2 months) and at 4 and 6 months after randomisation. descriptive analyses will be done to check for data normality. the between-group comparisons to obtain the mean effects of the treatments will be conducted by means of interaction terms (group versus time interactions) using linear mixed models. all data will be given to a statistician who will perform the statistical analysis in coded form. the statistical analysis will be done according to the principles of intention to treat. the spss 19 and sigmaplot 10 will be used for these analyses.

Eligibility criteria:
inclusion criteria: * subjects of both genders between 18 and 65 years of age with chronic non-specific lbp (pain for more than 3 months) with a pain intensity of at least 3 points measured by a 0-10 points pain numerical rating scale * subjects must be able to stand and walk independently * subjects must be able to read in portuguese exclusion criteria: * subjects with any contraindication to physical exercise according to the guidelines of the american college of sports medicine * subjects with severe depression (measured by depression, anxiety and stress scale - dass) * subjects with serious spinal pathologies (fractures, tumors, and inflammatory pathologies such as ankylosing spondylitis), nerve root compromise (disc herniation and spondylolisthesis with neurological compromise, spinal stenosis, and others), serious cardiorespiratory diseases, previous back surgery or pregnancy. * subjects that cannot be classified into any of the five categories of the movement system impairment model upon initial assessment

Keywords: low back pain, mechanical low back pain, low back ache, low backache, lower back pain, lumbago
glutamine challenge as predictor of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (tips)

Conditions: Refractory Ascites; Hepatic Hydrothorax; Hepatic Encephalopathy; Cirrhosis

Summary: transjugular intrahepatic portosystemic shunt (tips) is the first-line therapy for patients with cirrhosis and refractory ascites. however, mental changes known as hepatic encephalopathy (he) frequently occur after tips. there is no effective method to predict he after tips. oral glutamine challenge (ogc) and psychometric tests have been used to assess the risk for he, but never in patients undergoing tips. severe muscle loss may also predispose patients to he. the aim of the present study is to assess if both the ogc and psychometric tests can accurately predict the development of overt he after tips. patients will be studied before tips and followed after tips for the development of he. the role of muscle loss in favoring he, as well as is possible reversibility after tips will also be investigated.

in cirrhosis, up to 10% of patients develop refractory ascites. tips (transjugular intrahepatic portosystemic shunt) is the first-line therapy for these patients. however, 30% will go on to develop hepatic encephalopathy (he) as a consequence of tips, and there is no effective method to predict this outcome. oral glutamine challenge (ogc) is used to functionally assess ammonia metabolism, and the severity of porto-systemic collateralization, and it has been used to predict overt he. psychometric tests (i.e. psychometric hepatic encephalopathy score \[phes\] and inhibitory control test) allow the identification of covert forms of he and can also predict overt he. severe sarcopenia may also predispose patients to he. the aim of the present study is to assess if both the degree of impairment in ammonia metabolism as estimated with the ogc, and cognitive status as determined by psychometric tests, can accurately predict the development of overt he after tips. patients will be studied before tips and followed after tips for the development of overt he. the role of sarcopenia in favoring he, as well as is possible reversibility after tips will also be investigated.

Eligibility criteria:
inclusion criteria: * cirrhosis (any etiology) * refractory ascites or hepatic hydrothorax and plan for tips placement exclusion criteria: * well-documented overt hepatic encephalopathy, either persistent or at the time of screening * any contraindication for tips placement * except for coagulopathy and thrombocytopenia (decided on an individual basis) * uncontrolled depression/anxiety disorder or use of antipsychotic drugs * active use of alcohol or illicit drugs * history of dementia * tips planned for another indication. * active alcoholic liver disease.

Keywords: tips hepatic encephalopathy oral glutamine challenge psychometric tests portal hypertension cirrhosis
to study the feasibility and quality of life of medial group retropharyngeal node sparing in nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: this is an randomized, controlled, phase 3 clinical trial. the purpose of this study is to evaluate whether medial group retropharyngeal node （mrln） sparing could reduce the incidence of radiation-caused dysphagia and improve patients' quality of life without compromising survival rate.

in this study, patients with non-keratinizing stage t1-4 n0-3 m0 npc(uicc/ajcc 8th edition), except for patients with mrln metastasis, are randomly assigned to receive mrln sparing or prophylactic irradiation . patients in mrln sparing group will not routinely receive mrln irradiation to 56gy/33fr; while patients in mrln prophylactic irradiation group will always receive mrln irradiation to 56gy/33fr. our primary endpoint is local relapse-free survival (lrfs). secondary end points include overall survival (os), incidence of out-field recurrence rate, toxic effects, and quality of life (qol).all efficacy analyses are conducted in the intention-to treat population, and the safety population include only patients who receive their randomly assigned treatment.

Eligibility criteria:
inclusion criteria: 1. patients without medial group retropharyngeal node metastasis; 2. patients with newly histologically confirmed non-keratinizing (according to who histologically type); 3. tumor staged as t1-4n0-3(according to the 8th ajcc edition); 4. no evidence of distant metastasis (m0); 5. satisfactory performance status: karnofsky scale (kps) ≥ 70; 6. patients must be informed of the investigational nature of this study and give written informed consent. exclusion criteria: 1. patients with medial group retropharyngeal node metastasis; 2. aged \> 65 or \< 18; 3. treatment with palliative intent; 4. prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer; 5. pregnancy or lactation (consider pregnancy test in women of child-bearing age and emphasize effective contraception during the treatment period); 6. with history of previous rt (except for non-melanomatous skin cancers outside intended rt treatment volume); 7. prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes; 8. any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial.

Keywords: nasopharyngeal carcinoma medial group retropharyngeal node
a social media personalized normative feedback intervention for heavy drinking college students

Conditions: Alcohol Consumption

Summary: this study seeks to evaluate the unique and synergistic efficacy of social media-specific personalized normative feedback targeting the reduction of alcohol use among heavy-drinking college students who post alcohol-related content on social media. hypothesis: alcohol personalized normative feedback, social media-specific personalized normative feedback, and the alcohol personalized normative feedback+ social media-specific personalized normative feedback conditions will be more effective in reducing drinking than the attention control condition.


Eligibility criteria:
inclusion criteria: * college students recruited across three universities: duquesne university, miami university, and university of houston (du, mu, uh) * undergraduate college students 18 to 26 years old * meet heavy drinking (4+ drinks in one sitting for individuals assigned female at birth, 5+ drinks in one sitting for individuals assigned male at birth in the past month) and arc (alcohol-related content) posting criteria (2+ arc posts in the last 30 days for individuals assigned female at birth, 1+ for individuals assigned male at birth, on either facebook, instagram, snapchat, twitter, or tiktok) exclusion criteria: * pregnant or of another protected population

Keywords: social media
kinesiophobia after anterior cruciate ligament reconstruction.

Conditions: Kinesiophobia; ACL Injury

Summary: anterior cruciate ligament (acl) rupture is a serious trauma with long-term consequences to the athlete. psychological and physiological factors may negatively affect patient recovery and increase reinjury rate after anterior cruciate ligament reconstruction (aclr), and development of kinesiophobia is also possible.

anterior cruciate ligament (acl) rupture is a serious trauma with long-term consequences to the athlete. return to sports at the pre-injury level after anterior cruciate ligament reconstruction (aclr) is reported between 55 and 83%. psychological and physiological factors can negatively affect patient recovery and increase reinjury rate after aclr. in daily practice, surgeons and physiotherapists see athletes struggling to improve muscle strength and complaining of a lack of self-confidence and fear of reinjury during their progress to return to sports. kinesiophobia in aclr patients is used to determine fear of pain, lack of self-confidence, and fear of reinjury. patients with self-reported fear are less active, have decreased muscle function, and increased risk of a second acl injury. lower rates of return to sports are reported in athletes with kinesiophobia after aclr. to measure kinesiophobia, the self-reported tampa scale of kinesiophobia (tsk-17) test is widely used. the original tsk was developed and described by miller et al. in 1991. in aclr patients, the risk of developing fear was previously measured in a large systematic review of 2175 patients, in which 514 (24%) reported a psychological reason for not returning to sports.

Eligibility criteria:
inclusion criteria: * patients underwent aclr by three orthopaedic surgeons at the tartu university hospital sports traumatology centre between 2013 and 2019. exclusion criteria: * patients with revision aclr, bilateral aclr, and postoperative infections were excluded from the study.