Kornimate/medical-research-clean huggingface dataset:
registry of coronavirus complications - correlation with glycomic profile in covid-19 patients

Conditions: Chronic Pain; Morbidity, Multiple; Covid19

Summary: covid infection has resulted in multi-organ injury and may result in cardiovascular, pulmonary, neurological, and muscular damage. it is associated with significant asthenia and the long-term effects of the infection are still unclear, particularly for the development of pain and delayed functional rehabilitation. glycomics "is the systematic study of the structure of glycans in a given cell type or organism. glycans are complex oligosaccharides attached to proteins and lipids that regulate a variety of organic processes, including immunity thus, glycans may influence different moments of the response to the virus and involved in the clinical severity of the disease, but may also change depending on the severity of symptoms and the organic response to sars-cov-2 infection. glycomic data could provide important insights into interindividual differences at the molecular level that directly interact with sars-cov-2 and the development of mid- and long-term side effects. the ability to identify early those susceptible to developing covid-19 infection and at higher risk for covid-19 with unfavorable outcomes long after infection would help guide therapeutic strategy and provide important guidance for rational health care organization, which is of outmost importance. long-term outcome data regarding post-covid patient functional capacity and glycomics will be compared to assess whether there may be differences in protein glycosylation that may predict patient outcome.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of covid19 virus infection (buffer/bal/positive igg serology) * age \>18 years * able to express informed consent to participate in the study exclusion criteria: * patients unable to express consent, * patients aged \<18 yr, * with signs and symptoms compatible with covid-19 but without certified diagnosis by swab/bal or serological examination of presence of covid igg antibodies
effects of intragastric balloon on bone, metabolic and respiratory parameters

Conditions: Overweight; Obesity; Metabolic Syndrome

Summary: the purpose of this study is to evaluate the effects of intragastric balloon on bone, metabolic and respiratory parameters in 50 patients with metabolic syndrome.


Eligibility criteria:
inclusion criteria: * metabolic syndrome (idf criteria) exclusion criteria: * menopause * older than 50 years * diabetes mellitus
cognitive exercise therapy approach scale in patients with chronic neck pain

Conditions: Evaluation; Treatment

Summary: the aim of this study was to determine the validity, reliability and sensitivity of the cognitive exercise therapy approach scale in patients with neck pain.

according to the power analyzes 199 neck pain patients will be taken to the study.the study will be initiated after the approval of the ethics committee of the eastern mediterranean university faculty of health sciences. after informing about the content of the study, individuals who want to participate in the study will be asked to sign the informed consent form. in order to evaluate the validity and reliability of the bety scale in the study, the same individuals will be given a test-retest with 1 week intervals. in these tests, the neck disability index (ndi), arm shoulder and hand problems questionnaire (dash), short form-36 (sf-36), hospital anxiety and depression scale (hads) and bety scale will be applied.in order to assess the sensitivity to change, 44 individuals will be asked to re-fill the forms after the traditional physiotherapy program for neck pain, which will be administered 10 sessions. for 2 weeks, a routine exercise program consisting of 20 minutes of conventional tens, 20 minutes of hotpack, 8 minutes of therapeutic ultrasound and isotonic, isometric, stretching and relaxation exercises will be applied.

Eligibility criteria:
inclusion criteria: * individuals aged between 18-65 years * neck pain vas out of 3 and above which individuals * individuals who have neck pain for more than 3 months exclusion criteria: * patients with previous neck surgery history * not willing to participate in the study * attract trouble understanding for filling scale

Keywords: cognitive exercise therapy approach scale validity reliability responsiveness neck pain
type 2 diabetes and acute myocardial infarction

Conditions: Myocardial Infarction; Type 2 Diabetes; Impaired Glucose Tolerance; Inflammation

Summary: the present study was designed to determine the prevalence of previously unknown impaired glucose tolerance and type 2 diabetes in patients with acute st-elevation myocardial infarction subjected to acute pci. secondary, a possible association between inflammation, haemostasis and abnormal glucose regulation was studied.

background: a high prevalence of impaired glucose tolerance (igt) and unknown diabetes mellitus (dm) in patients with cardiovascular disease has been shown. european guidelines recommend screening of patients with ami for dm and igt by performing an oral glucose tolerance test (ogtt). the prevalence of igt and dm in a norwegian population of patients with ami is unknown. evidence are lacking regarding the reliability of an ogtt performed early after an ami. the present study was designed to detect unknown igt and dm in patients with ami and the main challenge of the study was timing and reproducibility of the ogtt. in addition, mechanisms (inflammation, haemostasis) involved in impaired glucose regulation will be studied. design: the study is designed as an observational cohort study prospectively including 200 patients with a primary pci treated acute stemi admitted to the coronary care unit at ullevål university hospital. an ogtt is performed in-hospital and repeated after 3 months and a glucometabolic classification was performed according to the results. the patients will be followed for a minimum of two-years with regards to clinical endpoints. aims of the study: 1. study the prevalence of igt and dm in a norwegian population with acute stemi. 2. validate the results of an ogtt performed early after myocardial infarction, by repeating the test after three months. 3. elucidate possible interactions between biomarkers of inflammation and coagulation, and the glucometabolic status. 4. study the relationship between impaired glucose tolerance and prognosis after stemi. 5. contribute to an increased focus on undiagnosed dm and igt in patients with coronary heart disease in norway and the results may lead to an increased use of routine ogtt in the follow-up of patients with myocardial infarction. investigate how patients with myocardial infarction and known glucometabolic state are followed up "in real-life" by their physicians. clinical implications: the study may detect a large proportion of undetected dm and igt in patients with ami and change present guidelines on the follow-up of patients after ami with increased focus on impaired glucose tolerance. the study will provide new insights about the association between inflammation, haemostasis and impaired glucose tolerance in patients with acute st-elevation myocardial infarction.

Eligibility criteria:
inclusion criteria: * patients with acute st-segment elevation infarction (defined from ecg), treated with primary percutaneous coronary intervention pci)were prospectively included. * stable patients exclusion criteria: * known dm * unstable patient * signs of heart failure * renal failure defined as creatinine \>200 umol/l
how is physical activity level and educational expectations of patient with knee osteoarthritis : epidemiological study in spa therapy

Conditions: Knee Osteoarthritis; Physical Activity

Summary: the primary purpose is to evaluate the level of physical activity in patients with knee osteoarthritis in a spa treatment and doing epidemiological study about this patient.

explain the physical activity level of knee osteoarthritis by socio-demographic, clinical variables, barriers and facilitators of regular physical activity practice, fears and beliefs about their condition, functional limitations and physical inactivity.

Eligibility criteria:
inclusion criteria: * patients, male or female, aged 50 to 75 years. * patients with knee pain reported to osteoarthritis * patient affiliated to a social security scheme (beneficiary entitled) * patient registered spa exclusion criteria: -

Keywords: physical activity level knee osteoarthritis non pharmacological treatment survey socio-demographic, clinical variables barriers, facilitators fears and beliefs function
local spraying of gm-csf via bronchoscopy in the treatment of autoimmune pulmonary alveolar proteinosis

Conditions: Pulmonary Alveolar Proteinosis

Summary: this study aims to explore a new therapeutic approach: the feasibility, safety and preliminary efficacy of directly spraying gm-csf into the airway through bronchoscopy for the treatment of apap.


Eligibility criteria:
inclusion criteria: 1. age: 18 to 60 years old; 2. a clear diagnosis of apap must meet at least one of the following diagnostic criteria: 1) balf appears "milky white"; or cytological examination reveals a large amount of pas-positive protein deposition; 2) hrct shows typical "paving stone-like changes"; 3) positive for serum gm-csf antibody. 3. there are more than one of the following treatment indications: symptoms such as progressive breathing difficulties, coughing, and shortness of breath after activity occur; 2) without oxygen inhalation, pao2 \> 65 mmhg 3) pulmonary function dlco accounts for % of the predicted value, ranging from 60% to 80%, including the critical value. 4. no other pap specific treatments (such as wll, inhaled gm-csf, biological agents, etc.) have been received recently (for more than 4 weeks). 5. agree to participate in this study and sign the informed consent form. exclusion criteria: 1. secondary pap (such as secondary to blood diseases, etc.); 2. patients with obvious pulmonary fibrosis, emphysema or irreversible lung function impairment; 3. patients in the acute exacerbation stage; 4. patients with other lung diseases (such as active pulmonary tuberculosis, bronchiectasis with purulent infection or other chronic infections; have severe asthma, chronic bronchospasm, etc. 5. have a history of allergy to gm-csf antibodies or related drug components; 6. patients who have participated in other clinical drug trials within the past three months; 7. patients who have experienced severe complications related to bronchoscopy or are intolerant to bronchoscopy; 8. concurrent with other serious cardiovascular and cerebrovascular diseases, hematological disorders, malignant tumors, etc. 9. pregnant or lactating women.
ali post radiation therapy in patients with lung and esophageal canter

Conditions: Solid Tumor Malignancies

Summary: the goal of this clinical research study is to learn if giving autologous lymphocyte infusions to patients who are receiving chemotherapy and radiation for non-small cell lung cancer or esophageal cancer is safe and effective.

the purpose of this study is to determine the safety and preliminary efficacy of un-manipulated autologous lymphocyte infusion (ali) using the patient's own lymphocytes collected using apheresis, and infused after the completion of radiation/chemoradiation. primary objective to investigate the preliminary efficacy of autologous lymphocyte infusion (ali) in improving the absolute lymphocyte counts in lung and esophageal cancer patients who had undergone chemo-radiation (crt). secondary objectives 1. to evaluate the feasibility and safety of ali in patients who had undergone chemoradiation. 2. to identify lymphocyte clonal populations in the tissue that are specific for tumor cells 3. to identify immune reconstitution in the peripheral blood shaped by ali. 4. to conduct clonal analysis using t-cell receptor (tcr) sequencing from tumor and from peripheral blood.

Eligibility criteria:
inclusion criteria: histologically or cytologically documented nsclc or esophageal cancers stage ii-iva disease where definitive chemoradiation is the standard of care age 18 exclusion criteria: prior radiotherapy to the chest life expectancy\<6 months any systemic therapy, aside from standard of care immunotherapy, that is planned to be administered prior to 6 weeks after ali. pregnancy
portable ultrasound to predict heart failure readmission risk

Conditions: Heart Failure; Patient Readmission

Summary: the purpose of this research is to use a handheld ultrasound to assess patients with congestive heart failure (chf) to see if the ultrasound can help predict readmission to the hospital. the study will include patients who are admitted to the hospital for chf. participants will have two ultrasounds at hospital discharge and at a follow up visit.

the purpose of this research is to see if a portable ultrasound can help predict readmission to the hospital for patients who are admitted to the hospital for chf. the study will enroll patients who take part in mobile integrated healthcare as part of their routine care. participants will have two ultrasounds. the first ultrasound will be at hospital discharge. between seven to ten days after hospital discharge participants will be visited at their home in follow-up as the usual standard of care for mobile integrated healthcare. at this visit participants will have a second ultrasound. participants will be followed for one year for hospital readmission.

Eligibility criteria:
inclusion criteria: * primary admission diagnosis is listed as congestive heart failure, with an acute component of decompensation. * age greater than 18 years. * principal residence within the geographic reach of our mih program. exclusion criteria: * pregnant women

Keywords: ultrasound
nmt for parkinson's disease

Conditions: Parkinson Disease

Summary: parkinson's disease (pd) is defined by characteristic motor symptoms including slow movements, small movements, difficulty with movement initiation and disruptions in timing. besides gross motor symptoms, fine motor impairments in pd cause difficulties with everyday tasks such as writing, self-care, and fine object manipulation. these activity limitations can lead to disability, social isolation, and a reduced quality of life. in a series of breakthrough studies michael thaut and colleagues developed neurologic music therapy (nmt) and found it can address many gross motor impairments and improve gait and balance. other music therapies such as music-supported therapy (mst) have proven motor benefits in stroke patients through movement exercises with musical instruments. however, the pathological basal ganglia (bg) in pd brains leads to a reduced supply of those internally generated movements. in contrast, externally cued movements (eg. via a beat or a rhythm) during nmt sessions are instantaneously entrained to the period of a rhythmic stimulus possibly without involvement of the bg. the underlying idea is that rhythm is the essential component relating music specifically to motor behavior. the mechanism of action is called "rhythmic entrainment" where one system's motion or signal frequency entrains the frequency of another system. the effect of nmt on fine motor function has not been investigated yet. music activities are important in the lives of many older adults. notably, the use of music has been associated with increased well-being for older adults, as it fosters social connection and mood regulation. furthermore, many musical activities have limited physical demands, making them attainable for individuals who are living with mobility impairments or other physical restrictions. based on the literature and the investigators preliminary studies, the investigators propose to test the efficacy of neurologic music therapy in comparison to music supported therapy and occupational therapy (ot) as standard of care on adults in the parkinson's spectrum. the investigators have defined a working plan using different musical instruments and growing tempo to specifically improve fine motor movements.


Eligibility criteria:
inclusion criteria: * age 45 to 85 * diagnosis of parkinson's disease using the uk brain bank criteria * fine motor impairments (if available, scores 2 and higher on the updrs motor examination part iii.23 and 24) * medication stable for at least 30 days. exclusion criteria: * features suggestive of other causes of parkinsonism, including cerebrovascular disease or history of major head trauma * inability to move fingers or hands * hoehn and yahr stage 4 and higher * ferrous metal implants which may interfere with the meg data acquisition and/or be an mri safety concern * dementia * participants engaged in other research studies involving music therapies * participants whose insurance does not cover occupational therapy costs or who have no insurance.
effect of anterioposterior weight shifting training with visual biofeedback in patients with step length asymmetry after stroke

Conditions: Stroke; Hemiplegic Gait

Summary: to investigate the effect of anteroposterior weight shifting training with visual biofeedback on step length asymmetry. reduced speed and asymmetry of stepping is a specific characteristic of hemiplegic gait. asymmetry of stepping is characterized by shorter step length of the unaffected limb compared to the affected limb. causes of this phenomenon are difficulty in weight bearing at the affected limb, weak propulsive force of the affected limb, and decreased strength of hip extensors. to correct these factors. we have developed an anteroposterior weight shifting training system with visual feedback and studied its effects.


Eligibility criteria:
inclusion criteria: 1. independent standing 2. ability to walk 10m without manual assistance 3. asymmetric ratio of step length \> 1.1 4. no severe perceptual, cognitive or cardiovascular impairments that could affect walking exclusion criteria: 1. quadriplegia or double hemiplegia 2. orthopedic or neurologic conditions in addition to the stroke 3. had more than 1 cerebrovascular accident

Keywords: anterioposterior weight shifting training patient
dynamic evolution of pulmonary nodules and influence factors of its clinical decision-making

Conditions: Pulmonary Nodule, Solitary; Pulmonary Nodule, Multiple

Summary: the researchers are aimed to investigate the dynamic evolution of indeterminate pulmonary nodules by a long-term follow-up of patients with different characteristics. influence factors of clinical decision-making that might contribute to overtreatment or delayed treatment will also be studied.

this observatory study prospectively recruits patients with indeterminate pulmonary nodules identified in computed tomography (ct) scans from thoracic clinic. the radiological features and their chronological changes during follow-up period will be recorded in detail. subgroup analyses will be performed based on the clinical and demographic characteristics of patients (including symptomatic information, comorbidities, family history, antibiotic usage, etc). hospital anxiety and depression scale (hads) is collected from each patient at multiple time points to evaluate the patients' psychological status and its impact on clinical decision-making. the interaction analyses between individual characteristics (such as education level, occupation, disease cognitive level, etc) and hospital anxiety and depression scale will also be performed. the researchers aim to provide high-quality evidence for the formulation of a precise follow-up and management plan for patients with pulmonary nodules.

Eligibility criteria:
inclusion criteria: 1. patients with pulmonary nodules ≤ 3cm 2. patients who provide electronic, written or oral consent to be enrolled in the follow-up cohort exclusion criteria: 1. patients with a surgical history of pulmonary nodules; 2. patients who have obtained pathological diagnosis through surgery or non-surgical methods such as puncture; 3. patients with pulmonary nodules that are likely metastatic from other sites; 4. refuse to participate in this study.

Keywords: pulmonary nodule radiologic picture prospective observatory study psychological state decision-making
genomically guided radiation therapy in the management of triple negative breast cancer

Conditions: Triple Negative Breast Cancer

Summary: the purpose of the study is to determine the feasibility of genomically guided radiation therapy (rt) in people with triple negative (her2 negative, hormone receptor negative) breast cancer undergoing breast conservation therapy.


Eligibility criteria:
inclusion criteria: * participants should have undergone breast conservation therapy with a lumpectomy and axillary evaluation to consist of a sentinel node biopsy or axillary dissection * confirmation of triple negative (tn) breast cancer by tissue biopsy * adequate tissue to calculate rsi * to fulfill the requirement of her2- disease, a breast cancer must not demonstrate, at initial diagnosis or upon subsequent biopsy, overexpression of her2 by either ihc or in-situ hybridization as defined by the asco / cap guidelines * to fulfill the requirement of hormone receptor (hr)- disease, a breast cancer must express (\<10%), by immunohistochemistry (ihc), the hormone receptors (estrogen receptor \[er\] and progesterone receptor \[pr\]) as defined in the american society of clinical oncology (asco) / college of american pathologists (cap) guidelines * life expectancy \>16 weeks * kps ≥ 70 * age ≥ 18 years * participants with surgery within 14 days should have recovered from all effects of the surgery and be cleared by their surgeon * there is no limit on prior systemic therapies * women of childbearing potential and sexually active males must commit to the use of effective contraception while on study * ability to sign an informed consent form, which can be signed by a family member or health care proxy. informed consent must be given before study enrollment exclusion criteria: * major surgery or significant traumatic injury that has not been recovered from 14 days before study initiation * women who are pregnant or breastfeeding * positive surgical margins * history of allergy or hypersensitivity to any of the study drugs or study drug components * metastatic breast cancer

Keywords: breast cancer genomically guided radiation