Kornimate/medical-research-clean huggingface dataset:
neural correlates of lower extremity motor recovery in stroke patients: longitudinal diffusion spectrum imaging studies

Conditions: Stroke

Summary: to investigate the relationship between the integrity of the white matter, including the corticospinal tracts and the corpus callosum, with the recovery of lower extremity function in patients with cerebral stroke at the subacute and chronic stages.

recent studies have provided strong evidence that motor recovery after adult ischemic stroke is a function of neural plasticity. up to date, it remains largely unknown as to the relationship between the integrity of the subcortical white matter with the lower extremity function recovery. given the fact that the white matter is more resistant to ischemia after acute stroke than the gray matter (falcao et al., 2004) and that the intensity of white matter in stroke has been found to be much greater in many brain areas in stroke than in healthy controls (wen et al., 2004), it is of interest to study how the integrity of the subcortical white matter, primarily the corticospinal tracts and the corpus callosum, contributes to the recovery of lower extremity function in subacute and chronic stroke with lesions involving different areas of the brain.

Eligibility criteria:
inclusion criteria: * between 30 to 80 years old * diagnosis of the first-time onset of stroke as confirmed by imaging studies * within 30 days post onset university hospital * brain lesions mainly involving either the cortical primary motor cortex (m1) area or confined to the subcortical (m1 spared) * no neurological or orthopedic problems which would affect their lower extremity function * no contraindications for mri studies exclusion criteria: * medically unstable * unable to communicate with the experimenters

Keywords: stroke diffusion spectrum tractography functional mri (fmri) lower extremity
limb-girdle muscular dystrophy type 2i in norway

Conditions: Limb Girdle Muscular Dystrophy, Type 2I; Limb Girdle Muscular Dystrophy; Muscular Dystrophies; Limb Girdle Muscular Dystrophy R9 FKRP-related

Summary: key goals are to establish the natural history of limb-girdle muscular dystrophy type 2i (lgmd 2i) and identify feasible and sensitive tools and biomarkers to measure disease affection and progression, determine the norwegian lgmd 2i prevalence, carrier frequency and genotypes, and to assess health-related quality of life in the norwegian lgmd 2i population. main aims are to facilitate future clinical trials and contribute to good clinical practice with suitable methodology and to complete health and social care in order to optimize the function and quality of daily living of the patient group.

a single-center study with norwegian nationwide enrollment. data is based on questionnaires, patient journals, clinical examination, a set of functional tests and biomarkers, and patient reported outcomes. clinical/ paraclinical tests are repeated after 2-years in order to measure disease progression. both skeletal muscle, heart and respiratory function will be examined. at baseline there will also be performed a sleep study in order to find if they are prone to sleep-disordered breathing.

Eligibility criteria:
inclusion criteria: * genetical confirmed limb-girdle muscular dystrophy type 2i in norway * live in norway * written consent exclusion criteria: * children \< 16 years are excluded from the assessment of quality of life and from the clinical/paraclinical part, but may contribute with information through questionnaires and patient journal. the study of prevalence and genotypes is anonymous and consent independent and will include everyone that is genetically lgmd 2i-confirmed in norway.
laser treatment of leg telangiectasias

Conditions: Leg Veins

Summary: is 1064 nm yag laser better than sclerotherapy to treat leg veins?

comparison between laser and sclerotherapy in the treatment of telangiectasias of legs.

Eligibility criteria:
inclusion criteria: * patients with leg telangiectasias exclusion criteria: * varicose veins * dvt * pregnancy

Keywords: laser telangiectasias leg veins sclerotherapy
effectiveness of scapular muscle training in improving grip strength among lateral epicondylitis patients

Conditions: Lateral Epicondylitis

Summary: the effectiveness of scapular muscular training along with conventional physiotherapy on the improving the grip strength of the patients suffering with the lateral epicondylitis was assessed by diving 56 patinets in two grousp as group a (n=28) was treated with conventional physiotherapy treatment and group b (n=28) was treated with scapular strengthening and conventional physiotherapy protocol.


Eligibility criteria:
inclusion criteria: * age: 20-50 years * gender: male and female * pain on the lateral epicondyle * vas scoring more than 4 * positive test: tomson test, mill's test , cozen;s sign and maudsley's test exclusion criteria: * any neurological/ radiculopathy signs in upper limb * cervical pain * bilateral elbow pain * history of elbow or wrist surgery * receiving any corticosteroid injection within last 6 months
effects of warm water on gi system in laparoscopic cholecystectomy patients

Conditions: Laparoscopic Cholecystectomy; Abdominal Distention

Summary: objective: the study was carried out to determine the effect of drinking warm water on gis functions in patients who underwent laparoscopic cholecystectomy surgery.

method: the research was completed in kahramanmaraş necip fazıl city hospital with 100 patients, 50 of whom were in the study group (wg) and 50 were in the control group (kg). the patients in cg were given warm water to drink at the 2nd hour after surgery. on the other hand, patients in kg were allowed to drink warm water after bowel sounds started and gas was produced. patients in both groups were 2,4,8,12 after surgery. hours were evaluated in terms of gis functions. statistical analysis was done in spss 22.0 for windows package program. a p\<0.05 value was accepted for statistical significance.

Eligibility criteria:
inclusion criteria: * over 18 years old * having surgery exclusion criteria: * not meeting the sampling criteria * refused to participate canceled surgery

Keywords: laparoscopic cholecystectomy bowel movements
effects of human papillomavirus diagnosis on relationships of patients with head and neck cancer

Conditions: Head and Neck Carcinoma

Summary: this trial studies the effects of human papillomavirus diagnosis on the relationships of patients with head and neck cancer. determining the effects of human papillomavirus diagnosis on relationships may determine whether human papillomavirus-positive patients and their partners are more likely to experience decline in relationship intimacy after diagnosis than human papillomavirus-negative patients and their partners. this may help researchers provide valuable insight into the degree to which a diagnosis of human papillomavirus affects patient relationships over and above the effects of a cancer diagnosis and address the need for additional patient counseling or education following diagnosis.

primary objectives: i. to explore the agreement between patients' perceived intimacy level and their partners' perceived intimacy level at different time points in the course of their head and neck cancer (hnc) treatment. ii. to compare any changes in the patients' perceived intimacy scores between human papillomavirus (hpv)-positive and hpv-negative hnc patients at different time points in the course of their hnc treatment. exploratory objective: i. identify areas of concern or misinformation among patients and partners where further patient counseling or education may be indicated. outline: patients and partners complete surveys over 10 minutes prior to surgery and 3-6 months after completion of treatment.

Eligibility criteria:
inclusion criteria: * capable of giving informed consent * diagnosis of head and neck cancer (previously untreated, any stage) or in a partnered relationship with an individual diagnosed with head and neck cancer * tumors positive for hpv * tumors negative for hpv * treatment plan is intent to cure * in a partnered relationship * willing to answer brief survey prior to treatment and again after completion of treatment * english speaking exclusion criteria: * prior treatment (surgery, chemotherapy, radiation therapy \[xrt\], or chemoradiotherapy \[crt\]) for head and neck cancer * partners of eligible patients undergoing active cancer treatment * not in a partnered relationship * non-english speaking
tech-tya: ehealth platform to deliver group intervention for ya cancer survivors

Conditions: Cancer

Summary: the purpose of this study is to adapt a web-based platform to deliver a group intervention for young adult cancer survivors.

in the first part of this study, the investigators adapted a website to deliver an evidence-based intervention for improving hrqol for young adult cancer survivors, and then conducted usability testing sessions with young adult cancer survivors to get feedback on the website. in the second part of the study, the investigators will conduct a single-arm pilot trial in which the website will be used to deliver the intervention via weekly group meetings with a trained facilitator over the course of 10 weeks.

Eligibility criteria:
inclusion criteria: 1. aged 18-39 years at the time of participation 2. diagnosed with a primary cancer between 18-39 years old 3. finished cancer treatment with curative intent 1 month to 5 years prior to enrollment (except hormone therapy) 4. ned and no anticipated/scheduled anti-cancer treatments at the time of enrollment (except hormone therapy) 5. able to speak and read english 6. able and willing to give informed consent 7. access to internet or cellular connectivity with sufficient bandwidth to participate in videoconferences (part 2 only) exclusion criteria: 1. ongoing or future anti-cancer treatments (beyond hormone therapy) are scheduled or anticipated 2. documented or observable psychiatric or neurological disorders that could interfere with study participation (e.g., psychosis, active substance abuse) vulnerable populations will not be included in this study.

Keywords: neoplasms quality of life young adults
local co2 increases core and wound temperature

Conditions: Hypothermia

Summary: eighty adult patients undergoing open colon surgery will be randomized to either:standard warming measures or to additional insufflation of humidified carbon dioxide in the open wound cavity during major abdominal surgery. primary aim is to test if core and local temperature can be increased.

eighty adult patients undergoing open colon surgery will be randomized to either: standard warming measures including heating sheets, warming of fluids, and insulation of limbs and head, or to additional insufflation of humidified carbon dioxide (approx. 30ºc, approx. 80-100% relative humidity) via a simple humidifier (sterile warmed water) connected to a gas diffuser (cardia innovation ab) that is able to create a local atmosphere of 100% carbon dioxide (humidified ) in the open wound cavity. primary aim the primary aim of this study is to evaluate if humidified carbon dioxide insufflated into an open surgical wound can be used to warm the core, open wound cavity, and the wound edges during major abdominal surgery. secondary aims secondary aims are to evaluate possible differences between the groups regarding complications and clinical differences including histological signs.

Eligibility criteria:
inclusion criteria: * major open abdominal surgery (colon surgery) in adults patient signed informed consent exclusion criteria: * acute surgery

Keywords: abdominal surgery hypothermia wound desiccation warming
preoperative renal insufficiency predicts postoperative adverse outcomes

Conditions: Renal Insufficiency; Morality

Summary: the main purpose of this study is to evaluate the risk of postoperative mortality and complications in surgical populations with preoperative renal insufficiency.

this retrospective cohort study use the national surgical quality improvement program (nsqip) database to evaluate the risk of postoperative morbidity and mortality in the surgical population. patients with estimated. glomerular filtration rate(gfr) \ 90 ml/min per 1.73 square meter are defined as patients without renal insufficiency. propensity score-matching methods and multivariate logistic regression are used to calculate the risk of postoperative morbidity and mortality.

Eligibility criteria:
inclusion criteria: * patients with estimated gfr \< 60 ml/min per 1.73 square meter or currently on dialysis are included in renal insufficiency group. * patients with estimated gfr \> 90 ml/min per 1.73 square meter are included in non-renal insufficiency group exclusion criteria: * patients population with estimated gfr between 60-90 is not included in the study
impact of flaxseed on the syndrome metabolic inflammation

Conditions: Metabolic Syndrome

Summary: this study aims to evaluate the effects of enterolignanas of flaxseed on nutritional and inflammatory indicators in male workers of a food industry.


Eligibility criteria:
inclusion criteria: * work in the manufacturing company in the city of itu-sp. * have at least three of the following cardiovascular risk factors: waist circumference ≥ 90 cm; overweight or obese characterized by bmi ≥ 25 kg/m²; fasting total cholesterol ≥ 200 mg/dl, ldl- cholesterol ≥ 130 mg/dl and hdl-cholesterol \< 40 mg/dl, triglycerides ≥ 150 mg/dl; glycemia ≥100 mg/dl; and hypertension characterized by systolic blood pressure ≥140 mm/hg and/or diastolic blood pressure ≥ 90 mm/hg. exclusion criteria: - female gender

Keywords: flaxseed lignans inflammation nutrition enterolactone enterodiol
a study to learn about the study medicine called vepdegestrant (arv-471, pf-07850327) in people with er+/her2- advanced breast cancer in china

Conditions: Breast Cancer

Summary: the purpose of this clinical trial is to learn about the pharmacokinetics. safety and tolerability of the study medicine (called arv-471) for the potential treatment of advanced estrogen receptor postive and human epidermal growth factor receptor 2 negative breast cancer. this study is seeking participants have * er+/her2- advanced breast cancer * received at least 1 line of endocrine therapy with or without cdk4/6 inhibitor * received up to 2 prior regimens of chemotherapy for advanced setting. all participants in this study will receive arv-471. arv-471 will be given by mouth at home once a day. the experiences of people receiving the study medicine will be examined. this will help determine if the study medicine is safe and effective. participants will take part in this study until their cancer is no longer responding. during this time, they will have visits at the study clinic about every 4 weeks.


Eligibility criteria:
inclusion criteria: * histological or cytological diagnosis of breast cancer with evidence of er+/her2- locally advanced or metastatic disease, which is not amenable to surgical resection or radiation therapy with curative intent. * received at least 1 line of soc of endocrine therapy with or without cdk4/6 inhibitor for locally advanced or metastatic disease. * up to 2 prior regimens of chemotherapy for advanced or metastatic disease setting are allowed. exclusion criteria: * known active uncontrolled or symptomatic cns metastases, carcinomatous meningitis, or leptomeningeal disease as indicated by clinical symptoms, cerebral edema, and/or progressive growth. participants with a history of cns metastases or cord compression are eligible if they have been definitively treated (eg, radiotherapy, stereotactic surgery) and clinically stable (including patients with residual cns symptoms/deficits) off enzyme-inducing anticonvulsants and steroids for at least 28 days prior to first dose of study drug. * any of the following in the previous 6 months: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure (new york heart association class iii or iv), cerebrovascular accident, transient ischemic attack, or symptomatic pulmonary embolism or other clinically significant episode of thromboembolic disease, congenital long qt syndrome, torsade de pointes, serious conduction system abnormalities (eg, bifascicular block defined as right bundle branch and left anterior or posterior hemiblock, 3rd degree av block), clinically important arrhythmias, left anterior hemiblock (bifascicular block), ongoing cardiac dysrhythmias of nci ctcae grade ≥2, atrial fibrillation of any grade.
a study evaluating safety and immunogenicity of meningococcal b rlp2086 vaccine in adolescents

Conditions: Meningitis, Meningococcal

Summary: the purpose of this study is to evaluate the safety and immunogenicity of an investigational meningococcal b rlp2086 vaccine in adolescents aged 11 to 18 years old.


Eligibility criteria:
inclusion criteria: * healthy male or female subjects between the ages of \>=11 and \<=18 years at the time of enrollment. * negative urine pregnancy test for all female subjects. * parent/legal guardian or subject under supervision of the parent/legal guardian must be able to complete all relevant study procedures during study participation. exclusion criteria: * history of any invasive meningococcal disease. * a previous anaphylactic or severe vaccine-associated adverse reaction. * any clinically significant chronic disease. * a known or suspected disease of the immune system or those receiving immunosuppressive therapy, including systemic corticosteroids. topical, inhaled or intra-articular corticosteroids are allowed. * participation in another investigational study in the 1-month (30-day) period before study visit 1 and during the conduct of the study.
comparison of the effects of dexmedetomidine and ketamine infusion on the inflammatory response in liver resection

Conditions: Inflammation; Analgesia

Summary: resection is being performed with increasing frequency in the treatment of surgical diseases of the liver. ischemia-reperfusion injury is a major cause of liver injury occurring during surgical procedures, including hepatic resection and liver transplantation. dexmedetomidine and ketamine, which are frequently used in anesthesia practice, also have strong anti-inflammatory capacity. the primary aim of this study is to investigate the effect of iv low-dose ketamine and dexmedetomidine infusion on inflammation in liver resection surgery, and the secondary aim is to determine its effect on pain scores.

general anesthesia will apply to all patients. group 1 (control group, n=15); after intubation, saline infusion will be started. the control group will also be infused with the same volume of saline. group 2 (ketamine group, n=15); after intubation, the patient will be started on ketamine infusion at a low dose of 0.25mg/kg/hour. group 3 (dexmedetomidine group, n=15); after intubation, the patient will be infused at a low dose of 1 mg/kg for the first 10 minutes, then 0.5 mg/kg/hour. for biochemical examination, blood will be taken for pedf (pigment epithelium-derived factor), pentraxin 3, serum amyloid a at the 1st and 12th postoperative hour. ast, alt, ggt, ldh, bilirubin, crp and hemogram results, which are routinely checked during these hours, will be recorded. all the patients were administered 1000 mg iv paracetamol 30 minutes before the surgery ended, and was repeated every 6 hours following the surgery.the postoperative analgesia was evaluated by using vas(visual analogue scale).the pca (patient controlled analgesia) device was programmed at 10 μcq concentration with loading dose 50 μcq, 15-minute lock time, 25 μcq bolus without basal infusion, and this was continued for 24 hours in the postoperative recovery room.

Eligibility criteria:
inclusion criteria: * asa (american society of anaesthesiologists) i-ii-iii group who will undergo liver resection surgery, * no known history of heart, kidney, hematological disease, peptic ulcer, gastrointestinal bleeding, allergy, chronic pain * who agreed to participate in the study exclusion criteria: * patients with underlying serious cardiovascular disease, * patients who cannot cooperate, patients who are allergic to one of the drugs to be used * patients who do not want to participate

Keywords: liver resection ketamine dexmedetomidine inflammation
the effects of toy in chıldren durıng inhaler therapy

Conditions: Lower Respiratory Tract Disease; Respiratory Disease

Summary: the purpose of the study is to investigate the effect of using a toy that children like during inhaler treatment on children's anxiety and emotional state. in the study, an inhaler treatment will be applied to children with a mask placed on a toy that they like. the purpose of this intervention is to reduce the child's anxiety and increase their emotional adjustment by improving adherence to the treatment.

respiratory diseases are commonly seen during childhood. today, inhaler medication is frequently used in the treatment of lower respiratory tract diseases. inhalation therapy is the process of delivering liquid medication in aerosol form directly to the respiratory tract and lungs using devices called nebulizers. compared to other treatment methods, the direct delivery of medication to the lungs, the rapid onset of effect, and fewer systemic side effects make inhalation therapy the preferred method for treating children. in treatments administered through inhalation, if the inhalation is being applied for the first time, the child may experience fear and anxiety due to not knowing the procedure. after the nurse explains how the procedure is done, they should use distraction techniques to relax the child and support the effective continuation of the inhalation treatment. distraction techniques are simple and inexpensive methods, and studies have proven their positive effect on children. this study is designed to investigate the effect of using a toy during inhaler treatment on children's anxiety and emotional state.

Eligibility criteria:
inclusion criteria: * the child being between the ages of 4 and 6, * the child being scheduled to receive their first inhaler treatment after admission to the unit, * no iv or im interventions being performed before the inhaler treatment, * the child and parents being willing to participate in the study, * no mental or neurological disabilities present in the child or parent, * the child not having any life-threatening illnesses, * the child having an oxygen saturation of 95% or higher, * the child's body temperature not exceeding 37.5 degrees celsius, * the child's cognitive level and motor development being appropriate for their age, * the child being able to count up to 10, * the parent being literate, * no visual or auditory problems present in the child or parent exclusion criteria: * the child's general condition (tachycardia, fever, vomiting, etc.) and orientation (disorientation, lethargy, etc.) significantly deteriorating after the inhaler treatment begins, * the parent or child wanting to withdraw from the study at any stage of the research.

Keywords: children inhalation therapy toy anxiety emotional state