Kornimate/medical-research-clean huggingface dataset:
a study to measure needle bending and changes in prostate shape during a prostate seed implant

Conditions: Prostate Cancer

Summary: prostate brachytherapy is an effective treatment option for men with localized prostate cancer, with excellent cure rates and a favorable toxicity profile. with the current needle insertion technique, seed placement inaccuracy is primarily caused by needle deflection and soft tissue deformation, which both occur during the brachytherapy operation. this study will accrue 20 patients undergoing prostate brachytherapy implants and acquire a series of ultrasound images, video clips and one ct scan.


Eligibility criteria:
inclusion criteria: * prostate cancer * treated with prostate brachytherapy at the cross cancer institute * low and intermediate risk prostate cancer * ambulatory patients * stable medical condition * over 18 years of age * capable of giving informed consent exclusion criteria: * any hormonal therapy

Keywords: needle deflection prostate deformation prostate brachytherapy needles
post hemorrhoidectomy anorectal pain

Conditions: Hemorrhoid Pain

Summary: this is a quality assurance trial to evaluate the effectiveness of guided breathing exercises on reducing the symptoms of hemorrhoidal disease in colorectal surgery patients. all patients who undergo hemorrhoid surgery are educated on breathing exercises that can be used to reduce pain and increase relaxation. these patients will be surveyed at their post-operative visit regarding pain and other symptoms and at their one month post operative visit on the any hospitalizations and emergency room visits since their surgery.

the effectiveness of guided breathing exercises on reducing the symptoms of hemorrhoidal disease in colorectal surgery patients will be assessed in this quality assurance trial. during the pre-operative clinic visit, patients to undergo hemorrhoid surgery are educated on breathing exercises that can be used to reduce pain and increase relaxation. in this year long study patient self-reported utilization of the breathing exercises and their level of pain, sleep quality, gastrointestinal symptoms (diarrhea, constipation, etc), emergency room visits, and hospitalizations in the month post hemorrhoid surgery will be evaluated. all patients will be asked to complete a brief survey at their pre-operative and one month post-operative visits.

Eligibility criteria:
inclusion criteria: * undergoing elective hemorrhoid surgery exclusion criteria: * emergent/urgent hemorrhoid surgery

Keywords: hemorrhoid pain deep breathing multimodal pain control
a study in healthy subjects to investigate pharmacokinetics of azd5423 when administered in different ways

Conditions: Bioavailability and AUC

Summary: the purpose of this study is to look at drug levels of azd5423 in blood when the drug is administered in different ways - orally, intravenously or inhaled (with four different devices), to healthy subjects

a phase i, single centre, open, partly randomised, crossover study in healthy subjects to evaluate azd5423 absolute pulmonary bioavailability when administered inhaled via a new dry powder inhaler, turbuhaler, spira nebulizer and i-neb aad system

Eligibility criteria:
inclusion criteria: * healthy male or women of non-childbearing potential aged 18-45 years inclusive with suitable veins for cannulation or repeated vein puncture * have a body mass index (bmi) between 19 and 30 kg/m2 (inclusive and rounding allowed) and weight between 50 and 100 kg (inclusive) * be able to inhale from the inhaler devices used in the study according to given instructions as well as be able to perform spirometry exclusion criteria: * history of any clinically significant disease or disorder * current smokers * any clinically relevant abnormal findings

Keywords: phase i, healthy male volunteers, pharmacokinetics
comparison of two pulse oximeters in delivery room

Conditions: Hypoxia

Summary: time to stable reading of oxygen saturation at the delivery room will be compared between two different devices.

after delivery babies will be located in the radiant warmer. the probe of each pulse oximeter will be applied to one of the feet. both probes will be simultaneously connected to the female plug of the pulse oximeter. heart rate will be checked time to get a stable reading in each device (by observation on the devices' display) will be recorded; this will be the primary study outcome. other vital signs (oxygen saturation, heart rate) and demographics) will be recorded as well. paired students t test will be used for the statistical analyzes.

Eligibility criteria:
inclusion criteria: * neonates in the operation or delivery room immediately after delivery whose parents agreed to enter the study exclusion criteria: * malformation of one of the legs, not allowing sensor application. any situation in which the study might interfere with the treatment of the newborn

Keywords: neonatal resuscitation pulse oximetry
effects of an intermittent reduced calorie diet on crohn's disease

Conditions: Inflammatory Bowel Diseases; Crohn Disease; Diet Modification

Summary: the purpose of this study is to see how an intermittent calorie reduced diet (ircd) that mimics fasting (also known as a fasting mimicking diet, fmd) effects inflammation in patients with mild to moderate crohn's disease (cd). the diet may allow users to receive the benefits of fasting while also being able to enjoy food (the ingredients of which are gras (generally recognized as safe) by the food and drug administration (fda). research on dietary interventions and cd are very limited. diets that mimick fasting have been studied with support of the national institute of health and published in leading journals. this research investigates whether markers of inflammation decrease and/or quality of life increases after five-day periods of the ircd, and may provide rationale for its use to treat cd.

as above

Eligibility criteria:
inclusion criteria: * mild to moderate crohn's disease (cdai score 151-450) * between the ages of 18-70 (inclusive) exclusion criteria: * women who are pregnant, nursing or expect to be pregnant * individuals allergic to nuts * individuals with a body mass index (bmi) lower than 18 * individuals diagnosed with a serious medical condition (unless approved in writing by a physician) * individuals who have been severely weakened by a disease or medical procedure * individuals who are taking medication which may not be safely consumed with a calorie restricted diet * individuals with diabetes who are taking anti-diabetic drugs associated with risk of hypoglycemia * individuals with more than mild-moderate cardiovascular disease or life-threatening cancer (as determined by patient's physician) unless approved by a physician * individuals with history of severe cardiac disease (particularly uncompensated congestive heart failure nyha grade 2 or more or lvef \< 40%) * individuals with a history of syncope * individuals with dietary needs incompatible with the ircd meal plan * individuals with liver or kidney disorders that may be affected by very low glucose and protein content of the diet * patients on a calorie restricted diet will also be excluded * patients with relevant prior gastrointestinal surgery and consequences such as short bowel syndrome, ostomy of small or large intestine,total colectomy, proctocolectomy, ileoanal pouch will be excluded (not excluded are patients with resection of terminal ileum, resection of short strictures of the small intestine, hemicolectomy).

Keywords: ibd crohn's disease diet fasting intermittent reduced calorie diet cd intermittent fasting fmd
effectiveness of managing suspected metastasis and progress using plasma d-dimer testing in gastric cancer patients

Conditions: Stomach Neoplasms

Summary: for prognosis evaluation, investigators enroll gastric cancer patients who underwent radical gastrectomy and collect the laboratory examination and clinicopathological characteristics. then independent risk factors for overall survival will be analysed. for predicting efficacy evaluation, investigators also collect information of patients first diagnosed with metastases. diagnostic efficacy is analysed by receiver operator characteristic curve method.

to investigate the novel predictive value of coagulation factors for postoperative outcomes after radical gastrectomy in patients with gastric cancer, investigators enroll patients with a pathologically confirmed diagnosis of gastric cancer who underwent radical gastrectomy between january 2021 and february 2017. patients follow up data were obtained by regular follow-up. the most recent preoperative laboratory tests and clinicopathological characteristics were evaluated. patients are devided into two groups according to our target indicator. the 5-year overall survival rate is analysed by kaplan-meier method. the independent risk factors for overall survival are analysed by cox proportional hazard regression method. investigators hypothesized that the target factor is closely related to disease progression. whether it can be used as a tumor marker to predict metastasis is to be studied. investigators collect laboratory examination including tumor markers of patients first diagnosed with metastases. diagnostic efficacy is analysed and compared by receiver operator characteristic curve method.

Eligibility criteria:
inclusion criteria: * all patients were newly diagnosed with gastric cancer; * all patients were pathologically diagnosed; * all patients had pre-treatment coagulation test; * stage i-iv disease; * age≥18 years exclusion criteria: * accompanying or secondary to other tumors; * had history of venous thrombosis or received any anti-coagulation treatment; * acute infection or intravascular disseminated coagulation; * pregnancy or lactation; * history of neoadjuvant chemotherapy; * lost to follow-up
modeling post-traumatic pain and recovery: the symbiome longitudinal cohort study

Conditions: Musculoskeletal Pain; Injuries

Summary: this study will explore the contribution of stress-system activity to pain and functional disability in the acute stage of traumatic musculoskeletal injury, and to the maintenance of symptoms after 3, 6 and 12 months post-injury.

purpose: the purpose of this protocol is to establish a longitudinal database of data collected from people having experienced an acute traumatic injury to their musculoskeletal system. this includes injuries commonly considered 'non-catastrophic' or 'minor' soft tissue injuries such as whiplash, low back injuries, sports or slip and fall-type injuries that result in sprain/strain of muscle, tendon, ligament or other such soft tissues. uncomplicated bony fractures (those that are managed through casting only, non-surgical) will also comprise this cohort. the data will include biological specimens, psychological and cognitive profiles, and social/environmental indicators. this protocol represents the start of the systematic merging of biology, mental health and environment (symbiome) project from the emerging solving traumatic pain and disability through advanced research translation (start) research group centred at western. over time, this database will allow rich exploration of complex interactions between biology, psychology and environment as they relate to the resolution of traumatic pain and disability, or similarly the persistence thereof. additional research ethics board (reb) applications will be submitted as those projects are ready to be formally conducted.

Eligibility criteria:
inclusion criteria: eligible participants: 1. will be aged 18 years or older 2. will be able to speak and understand conversational (grade 6) english 3. will be free of cognitive impairments that would interfere with ability to follow directions (e.g. diagnosed alzheimer's dementia, down's syndrome) 4. will be free of neuromuscular disorder that impairs mobility (e.g. stroke, multiple sclerosis, cerebral palsy, als) 5. will be free of active malignancies for the past 5 years 6. will be free of systemic inflammatory conditions, including rheumatoid or psoriatic arthritis, scleroderma, or systemic lupus erythematosus 7. will not have been diagnosed with a concussion over the previous 6 months (including the current injury) 8. will not have been hospitalized overnight over the previous 6 months (including the current injury) 9. will not have taken steroid-based medications (either prescribed or self-administered) over the previous 6 months 10. will not have required surgical correction/relocation as a result of the trauma (e.g. open reduction/internal fixation of a fracture). - exclusion criteria: * those who are under the influence of drugs or alcohol, or are otherwise not able to provide appropriate informed consent at the time of contact and those with no fixed address will be excluded.
role of folic acid in the management of adjuvant endocrine therapy-induced hot flashes in breast cancer patients

Conditions: THERAPY-INDUCED HOT FLASHES IN BREAST CANCER PATIENTS

Summary: the study's objective is to investigate the role of folic acid administration in the management of hot flashes associated with adjuvant endocrine therapy in patients with breast cancer.

folic acid is one of the b vitamins that when absorbed into its active form is converted to tetrahydrofolate. folate is an essential cofactor for the biosynthesis of norepinephrine and serotonin. studies have also noted that folate, with a mechanism like hormone replacement therapy (hrt), can improve hot flashes by interfering with monoamine neurotransmitters called norepinephrine and serotonin .the purpose of the current study is to investigate the role of folic acid administration in the management of hot flashes associated with adjuvant endocrine therapy in patients with breast cancer.

Eligibility criteria:
inclusion criteria: * females older than 18 years * diagnosed with confirmed breast cancer and currently treated with an adjuvant endocrine * experiencing bothersome hot flashes at least 14 times/week * taking the treatment within 6 months to two years. exclusion criteria: * known hypersensitivity to folic acid * patients who have been treated with selective serotonin reuptake inhibitors (ssris) within the past 30 days. * renal impairment is defined as a serum creatinine level greater than 2 mg/ld.. * significant liver disease: indicated by liver enzyme levels exceeding two times the upper limit of normal. * metastatic breast cancer * taking other medication for hot flashes * medications inducing hot flashes such as (clomiphene, opioids, nifedipine, prednisone)

Keywords: breast cancer hot flashes endocrine therapy folic acid
health and nutrition survey on shenzhen children

Conditions: Nutrition Disorder, Child; Nutrition Disorders in Adolescence; Nutritional Deficiency; Nutrition, Healthy; Nutritional Stunting; Nutritional and Metabolic Diseases; Nutritional Imbalance; Development, Child; Development, Adolescent; Growth Disorders; Growth; Stunting, Nutritional

Summary: 1. master and analyze the nutritional health, growth and development status of primary and secondary school students in shenzhen, and discover the main nutritional health, growth and development problems and influencing factors. 2. provide basic data and evidence-based basis for the municipal government and related departments to formulate child health policies and measures.


Eligibility criteria:
inclusion criteria: with signed consent to be a study subject. exclusion criteria: none.
ion prostate irradiation

Conditions: Prostatic Neoplasms

Summary: the purpose of this study is to evaluate the safety and feasibility of primary hypofractionated irradiation of the prostate with carbon ions or protons using the raster scan technique.

as published: habl g, hatiboglu g, edler l, uhl m, krause s, roethke m, schlemmer hp, hadaschik b, debus j, herfarth k: ion prostate irradiation (ipi) - a pilot study to establish the safety and feasibility of primary hypofractionated irradiation of the prostate with protons and carbon ions in a raster scan technique. bmc cancer 2014, 14(1):202. http://www.ncbi.nlm.nih.gov/pubmed/24641841

Eligibility criteria:
inclusion criteria: histological proven carcinoma of the prostate with gleason score risk of lymphe node involvement of \<15% calculated by the yale-formula; risk \[%\] = \[gs -5\] x \[psa/3 + 1.5 x t\], mit t = 0, 1, and 2 for ct1c, ct2a, und ct2b/ct2c * karnofsky-index ≥ 70% * age between 40 and 80 years * psa exclusion criteria: stadium iv (distant metastases) lymphogenous metastases hip replacement former irradiation of the pelvis pacemaker defibrillator

Keywords: prostate ipi hypofractionation carbon ions proton
autologous bone marrow cell treatment in peripheral atherosclerosis

Conditions: Peripheral Vascular Diseases

Summary: implantation of bone marrow cells, including endothelial progenitor cells, into ischemic limbs has been shown to improve collateral vessel formation. in the present study the safety and feasibility of autologous blood mononuclear cells implantation will be investigated in patients with severe peripheral atherosclerosis.twenty cases will be enrolled. improvement in the ankle-brachial pressure index (abi:\>0.1), ischemic ulcers and angiography as well as laser doppler flow will be evaluated until six months.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of third or fourth class of peripheral atherosclerosis exclusion criteria: * insuline dependent diabetes * cancer

Keywords: peripheral arterial disease, blood marrow cells, therapeutic angiogenesis.
adhesion of connective tissue around laser-treated abutments for dental implants - clinical trial in humans

Conditions: Periimplantitis

Summary: this study aims to demonstrate the histological differences in the connective tissue surrounding laser-treated abutments and untreated abutments in humans. working hypothesis: there are differences in the adhesion of collagen fibres around implant abutments with laser-produced microgrooves and standard abutments.

all patients will receive both abutment systems. the assignment of the abutments to each of the implants will be made randomly using spss 15.0 (spss inc., chicago, il, united states) software.

Eligibility criteria:
inclusion criteria: * patient must have partial edentulism of at least 2 teeth * patients that have scheduled treatment for the placement of at least 2 implants * patients with favourable attached gingiva * patients without systemic diseases that would prevent the emplacement of implants * patient must accept participation in the study by signing an informed consent form exclusion criteria: * smokers of 1 or more cigarettes per day * patients who suffer from any known condition that could be an absolute or relative contraindication to dental implant placement * patients requiring any additional surgical technique for bone or gum graft in order to insert the dental implant * patients who refuse to be included in the study or do not sign the informed consent form

Keywords: laserlok, connective tissue, adhesion
endodontic treatment of primary teeth with guedes-pinto paste without antibiotic

Conditions: Pulp Disorder

Summary: the pulp therapy in primary teeth is still necessary even with all odontopediatrics evolution in prevention and minimal intervention, aiming to keep the tooth free of inflammation or infection and in a functional state until its exfoliation. several materials are used as filling paste of primary teeth. in brazil, the guedes-pinto paste (pgp), an association of iodofórmio, camphorated paramonochlorophenol, prednisolone and rifamycin, has been widely used for some decades. however, current brazilian legislation has made it difficult to commercialize antibiotics, which has made it difficult to obtain the ointment that is the association between prednisolone and rifamycin. therefore, the objective of this clinical trial will be to test pgp without rifamycin in the pulpectomy of primary teeth, and to compare it with the treatment performed with conventional pgp.

a randomized triple-blind non-inferiority clinical study with two parallel arms, with a 12-month follow-up, will be performed. the experimental group will be pgp formulated without the antibiotic, while the control group is the conventional pgp, containing rifamycin. the conventional pulpectomy will be performed using manual files, performing the instrumentation aided by endo-ptc and 1% sodium hypochlorite. at the end of the instrumentation, just before the obturation, the groups will be drawn, with the strategy of randomization in permuted blocks and stratified by the initial condition of the tooth (with or without periapical lesion). the main outcome will be the clinical and radiographic success of endodontic treatment after 12 months. patients who seek the dental service of the municipality and require endodontic treatment will be invited to participate in the study. the data will be statistically analyzed using the statistical package stata 12.0 (stata corporation, college station, tx, usa). the longevity of the treatments will be evaluated by estimating survival rates using the kaplan-meier method. the differences between survival rates according to the type of endodontic treatment proposed will be analyzed through the log-rank test.

Eligibility criteria:
inclusion criteria: * primary molar teeth with necessity of endodontic treatment. * patients whose parents or guardians consent to their participation in the study exclusion criteria: * systemic health problems, congenital facial deformities, facial tumors or syndromes * teeth presenting one of the following: * resorption of more than 2/3 of the root * destruction of the crypt of the permanent successor * pulp chamber floor drilling. * presence of internal resorption

Keywords: pulpectomy primary teeth root canal filling materials
understanding local determinants of cardiovascular disease and diabetes

Conditions: Hypertension; Diabetes; Overweight and Obesity

Summary: cross-sectional survey of all adults residing in two defined geographical regions in urban lilongwe and rural karonga district. participants were interviewed, had anthropometric measures taken, and had fasting blood specimens taken.


Eligibility criteria:
inclusion criteria: * all adults over 18 self-identifying as normally resident in the pre-defined geographical areas exclusion criteria: * none