Kornimate/medical-research-clean huggingface dataset:
the use of manual therapy to treat low-back and hip pain

Conditions: Low Back Pain; Pain

Summary: low back pain (lbp) is a common problem in the adult population with many approaches to treatment, but no clear answer. one of the causes of lbp, musculoskeletal pain, can be triggered by spasm of the deep muscles of the back and pelvis. this study, therefore, focuses on treating pelvic muscle pain as a way of lessening lbp.

osteopathic manipulative medicine (omm) is a well-researched standard of care in the treatment of low back pain (lbp). under the heading of omm, many different modalities exist to decrease a patient's somatic dysfunction. among the most commonly used are high velocity (thrusting through an immobilized joint) and muscle energy (engaging a restrictive barrier using the patient's own strength). although a very common complaint, there is no exact etiology for lbp. many different theories exist, including postural disturbances, leg length discrepancies, and even genetic predispositions. a study in spine finds that among those with chronic lbp there is a subgroup of people with reduced hip flexion, and concludes that hip motion should be considered in treatment of patients with lbp. currently, there exists no research on the manipulation of hip flexors in the treatment of lbp. this study, therefore, will test the efficacy of omm on the deep pelvic musculature as a way of decreasing lbp.

Eligibility criteria:
inclusion criteria: * written informed consent * age-older than 18 years and younger than 65 years * lumbopelvic pain exclusion criteria: * cardiovascular disease (heart-failure, myocardial infarction, hypertension) * diabetes * rheumatoid arthritis * osteoarthritis * chronic illness * pregnancy-self reported * neurodegenerative disease * osteopenia * osteoporosis * metastatic cancer

Keywords: low back pain hip pain
determinants of daily physical activity level in patients with cystic fibrosis - pilot study protocol

Conditions: Cystic Fibrosis

Summary: the aim of the study is to analyze the determinants (barriers and facilitators) of the daily physical activity level in a population of patients with cystic fibrosis. a population of patients will be included in order to realize an assessment of their daily physical activity level over an entire week. a specific questionnaire, designed from 3 different questionnaires, will be associated to the physical activity evaluation and will allow to asses psycho-social and environmental factors.

physical activity (pa) is a major component of the management of patients with cystic fibrosis (cf). regular pa is associated, in cystic fibrosis as in other pathologies, with health benefits and a greater life expectancy. however, the literature shows an absence of consensus for the daily pa level reached by cf patients, and also for the determinants of this pa level. it appears that cf patients tend to have a reduced pa level, compared to international guidelines. some determinants have already been mentioned, like physical, psychological or organizational factors. but these factors have not been considered in a multifactorial way, by also considering social and environmental factors, and are rarely associated with objective pa level measurement or only reported in paediatric population. a better comprehension of these determinants of daily pa level represents an important issue for the optimization of interventions designed for the promotion of pa in cystic fibrosis. for this study, a population of cf patients will realize an evaluation of their daily pa level based on accelerometry (by wearing a portable device over 7 days). during the pa assessment, patients will have a questionnaire to fill in, delivered with the sensor. the objective assessment of pa level will be analyzed with regard to various parameters from different dimensions: individual, clinical, psycho-social and environmental. individual and clinical parameters will be collected from patients' data routinely assessed for the management of patients. psycho-social and environmental parameters will be assessed with a specific questionnaire, specifically designed from 3 different questionnaires.

Eligibility criteria:
inclusion criteria: * diagnosis of cystic fibrosis confirmed by the identification of genetic mutation and/or positive sweat test * regular follow-up in cf centers ; * age higher than 6 years old * stable clinical status, away from exacerbation period or antibiotic treatment. exclusion criteria: * transplant patient or patient waiting for a transplant * inability to fill in the questionnaire or to complete the planned evaluations * ongoing participation in another research protocol (interventional study) * refusal to participate in the study * patient under legal protection.

Keywords: cystic fibrosis barriers and facilitators daily physical activity accelerometry
a phase i study of gzr18 injection in healthy subjects

Conditions: Type 2 Diabetes; Overweight and Obesity

Summary: this trial is conducted in china. the aim of the trial is to evaluate the safety and tolerability of gzr18 injection in healthy subjects following single dose and once-weekly dose for 2 consecutive weeks until reaching the target dose.


Eligibility criteria:
inclusion criteria: * 1. subjects sign informed consent voluntarily. * 2. chinese adult subjects, male or female. * 3. age 18-55 at screening (both included). * 4. at screening and baseline, 19.0 kg/m2 ≤ bmi ≤ 26.0 kg/m2 (male ≥55.0 kg, female ≥45.0 kg). * 5. female subjects were human chorionic gonadotophin (hcg) negative at screening and baseline. exclusion criteria: * 1. history of dizziness with blood and needles. * 2. known or suspected allergy to study related products; or a history of drug and food allergies; or a history of allergy-related diseases. * 3. participants who participated in other clinical trials and were given the investigational drug or medical device intervention within 90 days prior to screening. * 4. blood donation, surgery, or trauma with significant blood loss (more than or equal to 400 ml, except for menstrual blood loss in women) within 12 weeks prior to screening. * 5. any clinically significant medical history judged by the investigator, including but not limited to: lung, gastrointestinal, liver, nervous system, kidney, genitourinary and endocrine, skin, or blood disorders, especially a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 , and a history of pancreatitis (acute or chronic). * 6. at screening or baseline, physical examination showed clinically significant abnormalities judged by the investigator.
intrastromal corneal ring for high astigmatism on postkeratoplasty

Conditions: Astigmatism

Summary: to evaluate the clinical outcomes of intrastromal corneal ring segment (icrs) implantation to correct high-degree astigmatism on eyes with prior penetrating keratoplasty (pk).

eighteen eyes of 18 patients, 8 men and 10 women, with high levels (\> 5 diopters \[d\]) of postkeratoplasty astigmatism were studied in a nonrandomized, retrospective, observational case series. mean age at the time of icrs implantation was 38 years, range 22 to 49 years. pk was performed to treat keratoconus in 15 patients, corneal scar after trauma in 2 patients, and fuchs endothelial dystrophy in 1 patient. all patients were spectacle and contact lens intolerant. there was no active corneal disease or problem apart from high astigmatism. minimum time of icrs implantation was 2 years after pk and at least 6 months after sutures removal. preoperative examinations included personal medical ocular history, uncorrected visual acuity (ucva), best spectacle-corrected visual acuity (bscva), refraction, keratometry, intraocular pressure (iop) measurement by applanation tonometry, corneal astigmatism, surface regularity index, surface asymmetry index, tonometry, slit-lamp biomicroscopy, specular microscopy, and fundus examination. main outcome measures included ucva, bscva, refraction, keratometry and computerized analysis of corneal topography. all surgeries were performed by the same surgeon (ban) at the goiania eye institute, between july 2007 and january 2009. corneal tunnels were created by means of mechanical dissection in all eyes. intrastromal corneal ring segments implantation was indicated because of the existence of reduced best spectacle-corrected visual acuity (bscva) or contact lens intolerance. intracorneal ring segments implantations were performed by the same surgeon following the same protocol. all eyes were implanted with the cornealring (visiontech medical optics, belo horizonte, mg, brazil). mean follow-up after icrs implantation was 12 months (range, 09 to 22 months). the procedure, its goals, and possible complications were explained and all patients signed an informed consent. the amount and axis of astigmatism to be corrected by icrs was based on manifest refraction.

Eligibility criteria:
inclusion criteria: * \> 5 diopters of postkeratoplasty astigmatism * patients 21 to 50 years old * conventional treatments have failed exclusion criteria: * diabetes * autoimmune diseases

Keywords: intrastromal corneal ring astigmatism postkeratoplasty eyes to evaluate the clinical outcomes of icrs implantation to correct high-degree astigmatism on eyes with prior penetrating keratoplasty (pk)
a multicenter survey study into patient experience with mobile apps

Conditions: Malignant Pleural Effusion

Summary: this multicenter prospective survey study is designed to evaluate a newly developed mobile app that will support patients with malignant pleural effusion (mpe) treated with an indwelling pleural catheter (ipc). the aim is to test the mobile app with patients with mpe and get user feedback during and at the end of the study period.


Eligibility criteria:
inclusion criteria: * patients with mpe and, scheduled for an indwelling pleural catheter (ipc) procedure, * age 18 or older exclusion criteria: * patients without an ios smartphone or email account * patients who refuse participation.
safety & efficacy of bct197a2201 in copd patients presenting with an exacerbation

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study will assess preliminary parameters of safety and efficacy of a single dose of bct197 in patients with a chronic obstructive pulmonary disease (copd) exacerbation.

this was an exploratory, double-blind, randomized, placebo-controlled, multicenter, adaptive parallel-group design study in four parts in patients with acute copd exacerbation. in part i, patients were randomized to receive either a single dose of 75mg bct197, placebo or 40 mg oral prednisone in the ratio of 1:1:1. in part ii patients were randomized to receive either a single dose of 20 mg bct197 or placebo in the ratio of 5:1. patients in parts i and ii received their single dose on day 1 of the study. in parts iii and iv patients were randomized to receive either bct197 or placebo in a ratio of 5:1 at a dose of 20mg (part iii) or 75 mg (part iv) with patients receiving a single dose on both day 1 and day 6 of the study.

Eligibility criteria:
inclusion criteria: * patients with copd (stage ii to iv) with a copd exacerbation. * smoking history of 10 pack years. * females must not be of child-bearing potential. exclusion criteria: * use of steroids in the last 30 days or calcium channel blockers in the last 48 hours. other protocol-defined inclusion/exclusion criteria may apply

Keywords: chronic obstructive pulmonary disease exacerbation pulmonary inflammation
genome, proteome and tissue microarray in childhood acute leukemia

Conditions: Leukemia

Summary: we will study gene and protein expression in leukemia cells of children diagnosed with acute leukemia. we hope to identify genes or proteins which can help us grade leukemia at diagnosis in order to: (a) develop better means of diagnosis and (b) more accurately choose the best therapy for each patient.


Eligibility criteria:
inclusion criteria:1. all children who present at packard hospital with a new diagnosis or relapse of acute leukemia will be eligible. there is no bias in regards to age range, gender or ethnic background. 2. signed informed consent
registry of patients living with type 1 diabetes

Conditions: Type 1 Diabetes Mellitus

Summary: a registry of individuals with type 1 diabetes open to all patients with type 1 diabetes living in canada will be established. the objective of this registry will be to measure the frequency and the severity of episodes of hypoglycemia. participants will be invited to answer questionnaires about the frequency of their hypoglycemic episodes, their fear about hypoglycemia, their symptoms of hypoglycemia, the factors in cause (insulin therapy, nutrition, exercise, etc.), etc. participation to the registry is divided in 3 phases. the first phase is mandatory for all participants. phases 2 and 3 are optional.

the objective of phase 1 is to draw an overall picture of the population with type 1 diabetes in canada in terms of demographics, diabetes treatment, hypoglycemia frequency and diabetes complications. it takes about 10 minutes to answer the questionnaire. if the participant uses a continuous glucose monitor and agrees, the participant is invited to send the latest report of the continuous glucose monitor. the objective of phase 2 is to characterize the causes, experience and consequences of hypoglycemia. phase 2 also involves, if the participant accepts and live in the province of quebec or alberta, to provide the research team with their latest blood and urine tests as well as their list of medications. the objective of phase 3 is to collect information on diabetes and hypoglycemia treatment, hyperglycemia management, sleep habits, depression, physical activity and the benefits of technologies to reduce the frequency of hypoglycemia. phase 3 also involves, if the participant agrees, answering a food questionnaire, wearing a step counter, measuring waist circumference

Eligibility criteria:
inclusion criteria: * diagnosis of type 1 diabetes * living in canada exclusion criteria: * type 2 diabetes * gestational diabetes
the reverse barrel™ vrd intracranial aneurysm trial

Conditions: Intracranial Aneurysms

Summary: the purpose of this clinical investigation is to evaluate the safety and effectiveness of the barrel™ vrd when used to facilitate endovascular coiling of wide-neck bifurcating or branch intracranial aneurysms with any approved embolic coils.


Eligibility criteria:
summary inclusion criteria: 1. male or female ≥18 years old. 2. a wide neck, intracranial, bifurcating or branch aneurysm with a neck ≥4 mm or a dome-to-neck ratio \<2, including non-de novo aneurysms where no stent was utilized. 3. subject's aneurysm arises from a parent vessel with a diameter ≥ 2.0 mm and ≤ 4mm, measured by 2d digital subtraction angiography (dsa). 4. subject responds to anti-coagulation and anti-platelet therapy according to the test used in each study center. 5. subject is eligible to undergo a procedure with the use of contrast media. 6. subject is willing to comply with protocol requirements and return to the treatment center for all required clinical evaluations and follow-up. 7. subject has given written informed consent. 8. life expectancy \> 12 months. - summary exclusion criteria: 1. subject presents with ruptured aneurysm, unless rupture occurred 30 days or more prior to screening. 2. subject is currently undergoing radiation therapy. 3. subject has known allergies to nickel-titanium metal. 4. subject has known allergies to aspirin, heparin, ticlopidine, or clopidogrel. 5. subject has a life-threatening allergy to contrast media (unless treatment for allergy can be tolerated). 6. subject has a known cardiac disorder, likely to be associated with cardio-embolic symptoms such as atrial fibrillation (afib). 7. subject has any condition, which in the opinion of the treating physician, would place the subject at a high risk of embolic stroke. 8. subject is currently participating in another clinical research study. 9. subject has had a previous intracranial stenting procedure associated with the target aneurysm. 10. subject is unable to complete the required follow-up. 11. subject is pregnant or breastfeeding.(females of childbearing potential must have a pregnancy test and provide written proof that they are not pregnant prior to inclusion.) 12. subject has participated in a drug study within the last 30 days. 13. subject who cannot or is unwilling to take asa/clopidogrel for a minimum of at least 3 months following the procedure. 14. extradural aneurysms. -

Keywords: intracranial aneurysm treatment endovascular therapy
reproducibility and repeatability of multifunctional mri biomarkers of the body

Conditions: Metastatic Liver Cancer

Summary: advanced mri (magnetic resonance imaging) technique called dce (dynamic contrast enhanced) and dwi mri can provide valuable information regarding tumor biology and response to treatment through various parameters. validating stability of these parameters will further establish robustness and reliability of these promising biomarkers.


Eligibility criteria:
inclusion criteria: * diagnosis of metastatic liver cancer proven by pathology * at least one liver tumor should be \> 2cm in long diameter * patients with viable tumor proven in the other imaging modalities exclusion criteria: * severe claustrophobia * presence of mri-incompatible metallic objects or implanted medical devices in body * renal failure, as determined by glomerular filtration rate (gfr) \< 30 ml/min/1.73 m2 * weight greater than that allowable by the mri table * chemotherapy within 28 days prior to enrollment * prior external radiation therapy to the liver, prior transarterial chemoembolization

Keywords: reproducibility of results liver neoplasm neoplasm metastasis regional perfusion perfusion magnetic resonance imaging
prestudy: lifestyle and cardiovascular disease

Conditions: Obesity; Diabetes Mellitus; Cardiovascular Diseases

Summary: the purpose of this pilot study is to optimize conditions for a planned human intervention study focusing on how diet predispose for, and influence, lifestyle disease development and its consequence in cardiovascular disease development.

common for many of the risk factors of lifestyle diseases is that they are induced by improper diet. recent research has shown that especially total amount and composition of the macro nutrients, protein, carbohydrate and fats, is important. a time course experiment has been performed where 5 subjects underwent a diet intervention for four weeks with a controlled, balanced macro nutrient energy content of every meal. the sampling time points were 0, 1, 2, 7, 14 and 28 days. the goals were to determine optimal length of intervention with stabilization of gene expression to occur and compare blood and subcutaneous abdominal fat tissue as source of biological material for rna for dna microarray analysis. microarray analysis were performed on 3 of the 5 subjects.

Eligibility criteria:
inclusion criteria: * healthy males, bmi\>30 exclusion criteria: * known chronic disease or in need of any medical treatment

Keywords: dietary intervention nutrigenomics diet, carbohydrate-restricted gene expression gene expression profiling oligonucleotide array sequence analysis biological markers food obesity blood subcutaneous fat, abdominal
observational study - ta- 2025-1

Conditions: Astigmatism

Summary: this multi-centric, prospective observational study collects biometric datasets as well as associated video recordings of the surgical procedure.


Eligibility criteria:
inclusion criteria: * diagnosed with cataracts (any grade), * seeking cataract treatment, * willing to provide informed consent. exclusion criteria: * active ocular infections or trauma. * poor fixation ability (e.g., severe nystagmus). * prior intraocular surgery. * seeking toric iol implantation requiring ink marking.
glidescope® versus macintosh laryngoscope for post-thyroidectomy assessment of vocal cord mobility

Conditions: Complication, Postoperative

Summary: vocal cord dysfunction is a serious post-thyroidectomy complication. this can lead to various postoperative clinical consequences as hoarseness of voice, aspiration or stridor . it is also one of the common reasons for post-thyroidectomy malpractice claims. this study will compare glidescope® with macintosh laryngoscope regarding accuracy of assessment of post-thyroidectomy vocal cord mobility.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status i and ii, * elective thyroid surgery with * normal thyroid profile exclusion criteria: * history of previous thyroid surgery, * preoperative vocal cord dysfunction * predicted difficult airway
unity-based mr-linac guided adaptive radiotherapy for high grade glioma: a phase 2 trial

Conditions: Glioblastoma Multiforme

Summary: glioblastoma (gbm) is a high grade glioma (brain tumor) that is treated with surgery or biopsy followed by radiotherapy (rt) given daily over 3 or 6 weeks with or without an oral chemotherapy. radiation is targeted to the visible residual tumor on magnetic resonance imaging (mri) images plus a large margin of 15 to 30 mm to account for possible cancer cells outside the visible tumor and for potential growth or shifts in tumor position throughout the prolonged rt course. standard rt uses mri to create a reference plan (with large margins) and treats that same volume every day. this exposes a large amount of healthy brain tissue to radiation leading to toxicity and reduced quality of life. a new technology, the mr-linac, combines an mri scanner and a linac (radiation delivery machine) into one unit. this allows for "adaptive" rt by obtaining an updated mri scan each day just prior to treatment, adapting the rt plan to take into account any changes in the tumor or the patient's anatomy on that given day. this allows for a smaller (5 mm) margin on the visible tumor as its position can be tracked daily. the goal of this study is to use adaptive rt with small margins to demonstrate that the local control of the visible tumor is not compromised compared to the large volumes used with standard non-adaptive rt, while determining whether smaller margins lead to decreased radiation toxicity and therefore improved quality of life by minimizing radiation exposure.


Eligibility criteria:
inclusion criteria: * patients aged 18 years and older * histopathologically confirmed malignant glioma of the brain, grade 4 (gbm) * eligible for rt in 15 or 30 fractions with or without chemotherapy (temozolamide) * expected survival greater than 12 weeks * who performance status less than or equal to 2 * able to converse and answer questionnaires in english language * has a maximum final planning volume less than 150 cm3 exclusion criteria: * contraindications to mri examination as per standard mri screening policy * contraindication to gadolinium-based contrast media * unable to lie flat in a supine position for 30 minutes * poor baseline kidney function with an egfr \< 60 ml/min * unable to tolerate immobilization in a head thermoplastic mask * patients \>140 kg and/or a circumference \>60cm * previous cranial irradiation * infratentorial tumour extent, multifocal of leptomeningeal disease * unable to give informed consent