Kornimate/medical-research-clean huggingface dataset:
the first failure study

Conditions: HIV; HIV Infections

Summary: the purpose of this study is to look at two different antiretroviral treatment options in individuals who are about to commence their second antiretroviral treatment. this study will assess important clinical and laboratory differences between these two therapeutic options. potential differences include: differences in body fat distribution, in lipid parameters, in adherence and in neurocognitive (brain) function. this study is looking to show differences in body fat distribution between the two study treatment arms. differences in lipids, viral load, adherence, cardiac and bone biomarkers and neurocognitive function will also be assessed. there is also a lumbar puncture sub study participants can also take part in. the total duration of involvement in the trial will be up to 96 weeks (approximately 2 years) plus a screening visit 1 - 4 weeks prior to the start of the study. including visit the clinic on 12 occasions (screening visit, baseline visit, weeks 2, 4, 8, 12, 24, 36, 48, 64, 80 and 96)


Eligibility criteria:
inclusion criteria: * hiv-1 infected males or females * over 18 years of age * signed informed consent * currently receiving a stable antiretroviral regimen comprising of: * two or more licensed nrtis * one licensed nnrti or boosted protease inhibitor * no previous protease inhibitor resistance documented on hiv-1 genotypic resistance testing * failure of current antiretroviral regimen due to: * toxicity, intolerance or virological failure if receiving an nnrti containing regimen at screening * toxicity or intolerance if receiving a boosted-protease inhibitor regimen at screening (with plasma hiv rna \< 400 copies/ml at screening) * willing to modify antiretroviral therapy, in accordance with the randomisation assignment * no previous exposure to etravirine * subjects in good health upon medical history, physical exam, and laboratory testing in the opinion of the investigator * have no serologic evidence of active hbv infection evidenced by negative hepatitis b surface antigen * female subjects who are heterosexually active and of childbearing potential (i.e., not surgically sterile or at least two years post menopausal) must practice contraception as follows from screening through completion of the study: * barrier contraceptives (condom, diaphragm with spermicide) * iud or depo plus a barrier contraceptive * female subjects of childbearing potential must have a negative pregnancy test. exclusion criteria: * current alcohol abuse or drug dependence * pregnancy * active opportunistic infection or significant co-morbidities * current prohibited concomitant medication * a likelihood of diminished response to any of the study treatment arms, in the opinion of the investigator, based on hiv genotypic resistance testing

Keywords: treatment experienced
effectiveness of nutritional products to treat moderate acute malnutrition

Conditions: Wasting; Moderate Acute Malnutrition

Summary: the purpose of this study is to determine whether an improved corn-soya blend (csb+) and a new formulated ready-to-use supplementary food (rusf) are effective in the treatment of moderate acute malnutrition in children.

assuming the availability of some food in the household, the caregivers were instructed on how best to use the food they have and the quantity of supplementary food distributed was calculated to provide about 50% of child energy requirement.

Eligibility criteria:
inclusion criteria: * children aged 6-59 month * weight-for-height between -3 and -2 z-scores without edema * good appetite * stable clinical conditions exclusion criteria: * weight-for-height z-score \< -3 * presence of bilateral pitting edema * unstable clinical conditions * not showing appetite
association between attention deficit hyperactivity disorder and bulimia nervosa in outpatients with eating disorders

Conditions: Bulimia Nervosa; Eating Disorders; ADHD

Summary: to understand whether a relationship exists between eating disorders and adhd, we seek to clarify the prevalence of adhd in individuals with eating disorders. to this end, we will estimate the prevalence of adhd, and other neuropsychiatric disorders, in outpatients with history of an eating disorder diagnosis. secondarily, we will identify patterns of cognitive deficits in outpatients with history of an eating disorder diagnosis. we will also examine whether adhd in this population is associated with functional and familial correlates associated with adhd.


Eligibility criteria:
inclusion criteria: * male and female outpatients between, and including, 18 and 55 years of age with a history of eating disorder diagnosis. exclusion criteria: * any clinically unstable psychiatric conditions such as: acute psychosis, acute panic, acute obsessive compulsive disorder, acute mania, acute suicidality, acute substance use disorders (alcohol or drugs), and sociopathy. * any metabolic, neurological, hepatic, renal, cardiovascular, hematological, opthalmic, or endocrine disease that would confound ability to participate in valid assessments. * mental retardation (iq \<75). * organic brain disorders. * non-english speaking subjects will not be allowed into the study because the assessment instruments are unavailable and have not been adequately standardized in other languages.

Keywords: bulimia nervosa eating disorder nos attention deficit hyperactivity disorder adhd
high molecular weight hyaluronic acid, α-lipoic acid, magnesium, vitamin b6 and vitamin d, in the prevention of spontaneous abortion

Conditions: Abortion, Spontaneous

Summary: the study aims to verify if the association of high molecular weight hyaluronic acid, α-lipoic acid (ala), magnesium, vitamin b6 and vitamin d, reduces the risk of miscarriage in patients at risk.


Eligibility criteria:
inclusion criteria: * two or more previous spontaneous first trimester abortions without apparent risk factors (idiopathic polyabortion) * endocrinopathies * autoimmune diseases * thrombophililic or coagulation diseases exclusion criteria: * multiple pregnancies * presence of genetic abnormalities of one or both partners leading to increased risk of fetal aneuploidies * presence of mullerian abnormalities in the uterus * symptoms present at recruitment such as pelvic pain or metrorrhagia
manual acupuncture using acupuncture needle vs press needle for covid-19 healthcare anxiety

Conditions: Anxiety

Summary: this study would like to compare manual acupunture treatment for anxiety in covid health workers population in cipto mangunkusumo hospital using filiform needles and press needle.

this study wanted to know would press needle be having better outcome for anxiety treatment, compared with filiform needles, because press needle taken home and could be manipulated as needed at home, unlike filiform needle where an acupuncturist must be available to do the treatment. furthermore, the press needle needed to be changed once within 5 days, that is 2-3 times in week. so we hope to have better acupuncture option (in effectivity and timewise) for covid healthcare workers anxiety treatment. there are no study to compare the usage of the two types of needles for anxiety treatment to date.

Eligibility criteria:
inclusion criteria: * covid-19 health workers. * rapid test covid-19 t or pcr swab non reactive within 7 days before intervention * ham-a score below 25 * could still do daily activities * willing to enroll this study and sign the informed consent * willing to comply with the study procedure exclusion criteria: * contraindicated for acupuncture : having medical emergencies, pregnancy, blood clotting issue, uncontrolled diabetic mellitus, fever. * having acupunture treatment within 7 days prior to study intervention * having tumor or infection at the pucture site * cognitive or consciouseness impairment * having anxiety therapy with a psychiatrist

Keywords: acupuncture press needle anxiety
a comparison of two different single doses of prednisolone on endodontic inter-appointment pain

Conditions: Endodontics; Pain

Summary: the purpose of this prospective randomized, double-blind, placebo-controlled study is to compare the efficiency of 2 different single doses of pre-operative oral prednisolone (20 \& 40 mg) for the control of inter-appointment endodontic pain in patients diagnosed with symptomatic irreversible pulpitis. the tested null hypothesis is that there is no difference in pain relief between the two doses. seventy-two patients presented for treatment at dental university hospital will be selected. the inclusion criteria are systemically healthy patients (asa classification i or ii), with no contraindications to corticosteroids (osteoporosis, systemic fungal infections, poorly controlled insulin-dependent diabetes mellitus, ocular herpes simplex, primary glaucoma, allergy to corticosteroids, ulcerative colitis, a compromised immune status, and major psychosis). patients under 18 years, pregnant or breast-feeding, took an analgesic agent within the last 6 hours, those with un-restorable teeth, teeth with periodontal disease will be excluded. patients having mandibular molars with symptomatic irreversible pulpitis with normal periapical area and moderate-severe preoperative pain (i.e. ≥ 34 mm on a visual analog scale (vas)) will be included. subjects will be randomly divided into 3 groups, namely placebo (control), 20 mg prednisolone and 40 mg prednisolone according to a computerized random numbers. each participant will receive a single oral dose of either formulation (drug or placebo) 30 minutes before starting endodontic treatment. all medications will be placed in identical containers and will be coded; thus, both the operator and the patients will be blinded to the type of medication. endodontic treatment will be performed and canals will be instrumented to a minimum of size 30, .04 taper following the standardized protocol. postoperative pain will be assessed by using a visual analogue scale at 4, 12, 24 and 48 hours after initiation of therapy.


Eligibility criteria:
inclusion criteria: * systemically healthy patients (asa classification i or ii), with no contraindications to corticosteroids (osteoporosis, systemic fungal infections, poorly controlled insulin- dependent diabetes mellitus, ocular herpes simplex, primary glaucoma, allergy to corticosteroids, ulcerative colitis, a compromised immune status, and major psychosis). exclusion criteria: * patients under 18 years, pregnant or breast-feeding, took an analgesic agent within the last 6 hours, those with un-restorable teeth, teeth with periodontal disease
foveal sparing ilm peeling with ilm flap transposition

Conditions: Full Thickness Macular Hole

Summary: foveal sparing internal limiting membrane (ilm) peeling with ilm flap transposition over the macular hole combines the benefits of foveal sparing ilm peeling with ilm flap techniques. aim of this study is to retrospectively examine the rate of postsurgical macular hole closure, development of central atrophy in the foveal area, and improvement of best corrected distant visual acuity in a group of patients having undergone foveal sparing ilm peeling with ilm flap transposition for macular hole repair.

idiopathic full thickness macular holes lead to central defects in the visual field and to deterioration of the visual acuity. introduction of internal limiting membrane (ilm) peeling techniques lead to significant increase in closure rates of the macular holes. foveal sparing ilm peeling represents a surgical technique for macular hole repair with less surgical trauma with high closure rates of the macular hole, compared to classic ilm peeling \[ho et al. 2014, murphy et al 2019\]. the combination of foveal sparing ilm peeling with the established ilm flap techniques \[michalewska et al 2010 und 2015\] offers the potential of better improvement in postsurgical visual acuity with the high closure rates, due to ilm flaps. aim of this study is to retrospectively examine the rate of postsurgical macular hole closure, development of central atrophy in the foveal area, and improvement of best corrected distant visual acuity in a group of patients having undergone foveal sparing ilm peeling with ilm flap transposition for macular hole repair.

Eligibility criteria:
inclusion criteria: * vitrectomy with foveal sparing ilm peeling with ilm flap transposition in the time period from 1.10.2020 to 8.7.2022 * age 18 and older * idiopathic full thickness macular hole as indication for surgery * full follow-up, including visual acuity testing and oct preoperative, and 3 months after surgery. exclusion criteria: * age \<18 years
validation of a scale of well-being at work

Conditions: Adjustment Disorder

Summary: the main objective of this work is to explore the psychometric properties of scale of well-being at work called "serenat" in order to validate it. secondary objectives are to study the influence of socio-demographic characteristics of the subjects on the results of serenat and to describe the results on subjects monitored among an adult psychiatric population.

this is a cross sectional survey. 200 subjects were selected among people having consulted an occupational doctor to validate the scale in the general population (study 1), and 50 subjects among a psychiatric population for the ancillary study (study 2). the serenat scale is a self-report questionnaire composed of 20 items. all items are scored on a four point likert scale ranging from 0 (strongly disagree) to 3 (strongly agree) resulting in a range of 0 to 60. the 20 items are related to different domains. 10 items explore psychological balance at work: relaxation (item 1), sleep quality (item 2), concentration (item 3), form (item 4), sense of security (item 5), satisfaction (item 6), quality of relationships and contacts at work (item 7), voltage or aggressiveness (item 8), optimism for the future from a professional point of view (item 9), life balance (item 10). 10 items are related to working conditions and organization of work: comfort of the working environment (item 11), time constraint (item 12), sense of competence (item 13), decision latitude (item 14), interest at work and variety of tasks (item 15), recognition (item 16), professional support (item 17), communication and transfer of information (item 18), human conflict (item 19), satisfactory work schedules (item 20).

Eligibility criteria:
inclusion criteria: * agree to participate, exert a professional activity for at least 3 months at the time of inclusion, consult an occupational doctor or go to consultations related to stress and anxiety, read and be able to respond to the scale, exclusion criteria: * not be acting on work stoppage, nor pregnant, be capable of consent, not benefit from any legal protection regime and not be deprived of freedom.

Keywords: mental health well-being at work screening psychosocial risk psychometrics questionnaire job stress
causes of death in follicular lymphoma: a single center retrospective analysis

Conditions: This Study Describes the Different Causes of Death in 237 FL Patients

Summary: background.although the life expectancy of patients with fl has recently increased, notably since the introduction of rituximab in combination with chemotherapy, little is known regarding the precise causes of patients death. patients and methods'. this study describes the different causes of death in fl patients among followed since 2000 at lyon university hospital, centre léon bérard and mayo clinic. the causes of death will be classified as related to lymphoma progression, treatment-related toxicity (including trm and secondary myelodysplastic syndrome/acute myeloid leukemia), secondary neoplasias, or other.


Eligibility criteria:
inclusion criteria: * fl patients * patients recorded as deceased exclusion criteria: -other diagnosis than fl

Keywords: follicular lymphoma; death, rituximab, treatment related toxicity
diagnostic accuracy of direct mr arthrography of the wrist at 1.5, 3.0 and 7.0t

Conditions: Wrist Injuries

Summary: the purpose of our study is to evaluate the diagnostic accuracy of mr arthrography of the wrist at 1.5, 3.0, and 7.0t with wrist arthroscopy as reference standard.


Eligibility criteria:
inclusion criteria: * age \>18; * clinical evidence for wrist joint abnormalities; * request for mr arthrography prior to wrist arthroscopy; * willingness to take part in our study with written informed consent; exclusion criteria: * age\<18; * history of prior wrist surgery; systemic diseases e.g. rheumatoid arthritis; * infection; history of adverse contrast reactions; * contraindication for mr imaging (e.g. pacemaker, metallic implants, etc.); * history or possible signs of renal failure (see section "nephrogenic systemic fibrosis")

Keywords: wrist abnormalities
prospective study of white blood cells

Conditions: Autoimmune Diseases; Inflammation; Rejection; Transplant, Liver

Summary: the purpose of this study is to investigate white blood cells from volunteering donors to support the development of engineered regulatory t cell therapies.


Eligibility criteria:
no additional inclusion/ exclusion criteria will be applied by quell other than those specified by the consenting institutions.
asthma surveillance and education in preschool settings

Conditions: Asthma

Summary: the purpose of this study is to test the effectiveness of a bilingual intervention in improving asthma care for low-income inner-city children enrolled in subsidized preschool childcare programs.

background: proposed is a non-randomized, controlled, prospective trial to test the efficacy of a bilingual intervention to improve asthma care for low-income inner-city children enrolled in subsidized preschool childcare programs. because of high rates of asthma prevalence, subsidized preschool childcare programs offer ideal settings to test innovative strategies to improve asthma care within communities at highest risk of morbidity. design narrative: the study will comprise three arms. arm 1 is surveillance, in which children with asthma are identified. in arm 2, children with asthma are identified and given written asthma action plans (monitoring). arm 3 consists of surveillance, monitoring, and education.

Eligibility criteria:
inclusion criteria: * enrolled in specific subsidized preschools in new york city * 2.8 to 4 years old * persistent asthma as defined by symptom reports * use of quick-relief agents or controller medications exclusion criteria: * history of intubation
2nd line gemcitabine monotherapy for transitional cell carcinoma of urothelium (tcc) after cddp regimen

Conditions: Urologic Neoplasms; Carcinoma, Transitional Cell

Summary: to investigate efficacy and safety of 2nd line gem monotherapy after cddp regimen for patients with transitional cell carcinoma of urothelium


Eligibility criteria:
inclusion criteria: * histologically and/or cytologically confirmed tcc * received 1st line chemotherapy for locally advanced or metastatic tcc with cddp regimen * to have at least one measurable region * ps: 0-2 * to have adequate organ function (bone marrow, liver and renal function) exclusion criteria: * to have interstitial pneumonia or pulmonary fibrosis * within 4 weeks after the latest chemotherapy or radiotherapy * to have brain metastasis with symptom * to have severe complication (cardiac infarction, infection, drug hyper sensitivity or diabetes)

Keywords: transitional cell carcinoma of urothelium
perceptions of undergraduate students and teaching staff on online teaching

Conditions: Covid19

Summary: spread of covid-19 in the world has led to a shift in teaching and learning techniques to online methods in order to prevent transmission of the disease. misr international university (miu) has an established online learning system that has been used together with face-to-face classes. the aim of this study is to assess and compare the satisfaction and perceptions of full-time teaching staff and undergraduate students regarding online learning during covid-19 crisis.

statement of the problem: spread of covid-19 in the world has led to a shift in teaching and learning techniques to online methods in order to prevent transmission of the disease. misr international university (miu) has an established online learning system that has been used together with face-to-face classes. however, shifting all courses in all the faculties to the online mode is a new experience that needs to be assessed to allow for future improvement plans. aim: to assess and compare the satisfaction and perceptions of full-time teaching staff and undergraduate students regarding online learning during covid-19 crisis. method: an online anonymous questionnaire will be distributed to all misr international university (miu) students and staff members. the total number of students is 8679 and the total number of staff members regardless of their academic title is 530. the questionnaire will be validated by three experts and piloting will be performed on a sample of participants. the questionnaire consists of five sections: demographics, satisfaction with online teaching and learning methods, knowledge, and perception of covid-19.

Eligibility criteria:
inclusion criteria: * all miu undergraduate students and full-time staff members exclusion criteria: * students or full-time staff members who will not respond to the questionnaire

Keywords: online learning teaching methods covid-19 knowledge and perceptions
prevention of intradialytic hypotension in acute kidney injury patients

Conditions: Acute Kidney Injury; Acute Renal Failure

Summary: intradialytic hypotension (ih) is a major complication during acute hemodialysis. the aim of this study was to evaluate the effects of dialysate temperature (dt) reduction with na and ultrafiltration (uf) profiling on hemodynamics of critically ill acute kidney injury (aki) patients submitted to sustained low-efficiency dialysis (sled).


Eligibility criteria:
inclusion criteria: * acute renal failure with a need of dialysis. exclusion criteria: * patients with basal serum creatinine \> 3 mgdl. * patients submitted to renal transplantation. * patients unlikely to survive. * declination in authorization to participation in the study.

Keywords: hypotension acute renal failure acute kidney injury dialysis icu