Kornimate/medical-research-clean huggingface dataset:
serum magnesium levels in desalination tap water and outcomes in acute myocardial infarction patients

Conditions: Myocardial Infarction; Death; Congestive Heart Failure; Acute-MI; Cardiovascular Disease

Summary: association between serum magnesium and clinical outcome in patients with acute mi (ami) with 1 year follow-up in 300 patients in regions supplied by desalinated drinking water (dsw) (sheba mc) and 150 patients in regions with non-desalinated drinking water (dw) (nahariya mc).

extensive seawater desalination in israel may decrease magnesium in drinking water (dw), causing hypomagnesemia and adverse health effects. we study the association between consumption of desalinated drinking water (dsw) and serum magnesium in acute mi (ami) patients, subjects 35-75 years of age with the first ami will be prospectively recruited during 1 year from 2 regions; the departments of cardiology at the sheba medical center (300 patients, predominantly served by dsw) and the nahariya medical center (150 patients, served by non-dsw). questionnaire will be developed to collect data on demographic variables (at home and work), water and beverages consumption habits (tap water, mineral water), dietary sources of mg and mg supplementations. mg levels will be measured in dw from the patients' homes and in their serum on admission.

Eligibility criteria:
inclusion criteria: 1. patients with first ami 2. age 35-75 exclusion criteria: 1. patients \> age 75

Keywords: desalinated sea water magnesium drinking water
gastric emptying after sleeve gastrectomy

Conditions: Gastric Emptying; Bariatric Surgery

Summary: sleeve gastrectomy (sg) increases gastrointestinal motility, which influences feelings of fullness and satiety. by understanding the differences in gastric emptying (ge) between patients with sufficient weight loss (total weight loss \[twl\] \> 35%) and insufficient weight loss (twl \< 25%), better insight in the aetiology of weight loss after sleeve gastrectomy may be obtained. ge will be measured with scintigraphy and mri.

sleeve gastrectomy (sg) increases gastrointestinal motility, which influences feelings of fullness and satiety. patients' weight loss response on sg varies widely and is difficult to predict. by understanding the differences in gastric emptying (ge) between patients with sufficient weight loss (total weight loss \[twl\] \> 35%) and insufficient weight loss (twl \< 25%), better insight in the aetiology of weight loss after sleeve gastrectomy may be obtained. ge will be measured with scintigraphy and mri. mri is a non-invasive imaging method which provides more detailed images of the sg compared to the conventionally used scintigraphy scans.

Eligibility criteria:
inclusion criteria: * women aged between 20 and 55 years who underwent sleeve gastrectomy as primary procedure with either twl \ 35%. * patients who had a follow-up period of 2-3 years after sleeve gastrectomy exclusion criteria: * maximum bmi \>50 kg/m2 * patients with a disease known to affect appetite, gastric emptying or gastrointestinal motility * patients who are unable to stop medications that affect gastric emptying and/or motility prior to measurements. it is depending on t1/2 for how long they need to stop medication * patients who started menopause * patients with gastrointestinal problems or, gastric or intestinal diseases * patients with a drug or alcohol addiction * patients who are unable to stop smoking for 24h * patients who are pregnant or lactating * patients who have an intolerance or allergy for one of the components of the test product * patients who have a contra-indication to mri scanning

Keywords: gastric emptying gastric sleeve mri scintigraphy
wearable electronic breath sound sensing device

Conditions: Asthma in Children; Asthma Attack

Summary: this study will assess the ability of a wearable stethoscope to monitor wheezing in high-risk asthma patients admitted at children's healthcare of atlanta. this study is important to assist in the health management of patients with chronic lung diseases that can experience exacerbations leading to their health worsening and requiring hospitalization. the population that will be approached for this study will include 10 pediatric subjects hospitalized at children's healthcare of atlanta for an asthma-related exacerbation. participants will wear the patches for up to 8 hours on their chest and back wall from their date of consent until their hospital discharge. this may range from the participant taking part in 1 to 14 visits that could last up to 8 hours.

the main goal of this study is to evaluate the ability of a novel wearable breath sound sensor (wearable stethoscope) to continuously monitor breath sounds, specifically wheezing, in pediatric asthma patients during hospital admission. the data collected will be used to develop a wheeze detection algorithm. the breath sound recordings from this device will not be used for any medical decision-making or treatment changes, and all study participants will continue to receive routine medical management per standard of care guidelines.

Eligibility criteria:
inclusion criteria: * age 6-17 years * diagnosis of persistent asthma * being treated for an acute asthma exacerbation * parent can speak and understand english exclusion criteria: * unable to provide consent for the study * history of prematurity * history of other chronic lung conditions - cystic fibrosis, bronchiectasis, or primary ciliary dyskinesia * history of latex allergy or allergy to medical tape adhesive * patients currently using another medical device - implanted pacemaker or vagal nerve stimulator or diaphragm pacing device

Keywords: hospital admission wearable stethoscope asthma exacerbations
efficacy of two internet delivered intervention programs for depression: behavioral activation vs physical activity

Conditions: Major Depressive Disorder

Summary: to compare the clinical and cost-effectiveness of behavioral activation (ba) and physical activity (pa) for adults with major depressive disorder (mdd) or adjustment disorder with depressive symptomatology with a wait list control group (wl) in spanish population.

research shows that in 2030 (mathers and loncar, 2006) depression will become one of the three leading causes of disability. depression is a common mental disorder with a negative impact on mental well-being, quality of life, and social and work-related functioning both in the short and longer term. additionally, depression is associated with increased morbidity, mortality, health care utilization and health care costs. on a population level, depression is one of the most costly diseases. the economic costs of depression were estimated at €136.3 billion (eu25) in 2010 in the eu and are still rising. european health care systems face the challenge of improving access to cost-effective treatments while simultaneously working to sustain budgetary stability in times of economic austerity. internet-based depression treatment appears a very promising alternative to current routine depression treatment strategies. meta-analyses have demonstrated the clinical effectiveness and potential cost-effectiveness of internet-based treatment for depression in controlled research setting. internet-based treatment thus has the potential to keep depression treatment affordable, as it enables mental health care providers to reach out to large populations needing depression treatment at a better cost-effectiveness, but with similar levels of clinical efficacy and quality of care. in spain the trial will be carried out in a community sample, comparing the clinical and cost-effectiveness of ba or pa with wl for adults with major depressive disorder (mdd) and adjustment disorder with depressive symptomatology. respondents will be followed until 6 months after baseline (measures will be taken at bl, 3 months, and 6 months).

Eligibility criteria:
inclusion criteria: * being 18 years of age or older * meet dsm-iv diagnostic criteria for mdd and adjustment disorder confirmed by mini international neuropsychiatric interview version 5.0 and scid i * a score of 5 or higher on the phq-9 screening questionnaire. exclusion criteria: * current high risk for suicide according to the mini interview section c * serious psychiatric co-morbidity: substance dependence, bipolar affective disorder, psychotic illness, obsessive compulsive disorder, as established at the mini interview * currently receiving psychological treatment for depression in primary or specialised mental health care * being unable to comprehend the spoken and written language (spanish) * not having access to a pc and fast internet connection (i.e. broadband or comparable).

Keywords: internet based treatment depression efficacy cost-effectiveness behavioral activation self-applied ecological momentary assessment physical activity
social groups for australian children on the autism spectrum

Conditions: Autism Spectrum Disorder

Summary: this study evaluates the kontakt social skills group training in australian children on the autism spectrum compared to an active control group which is a group art class

kontakt is a manualized social skills group training program designed for children and adolescents with asd which aims to improve communication, social interaction skills, reduce the severity of asd symptoms, improve the ability to empathise and adapt in a group setting. a large randomized controlled trial in sweden found that adolescents who participated in kontakt demonstrated improvements in social skills, behaviour, reduced stress and improved overall functioning as reported by parents immediately following and at three months after the program. however, social skills are at least in part influenced by social cultural contexts and there is a need to understand the feasibility, acceptability and effectiveness of kontakt in an australian context. moreover, in the previous studies, the social skills groups were compared to treatment as usual groups. therefore, this study evaluates the kontakt social skills group training in australian children on the autism spectrum compared to an active control group which is a group art class

Eligibility criteria:
inclusion criteria: * individuals aged 8 to 12 * clinical consensus diagnosis of asd as defined by dsm-5 and confirmed by the autism diagnostic observation schedule-2 * iq scores \> 70 as measured by the wechsler abbreviated scale of intelligence - second edition (wasi-ii) exclusion criteria: * existing prior comorbid externalizing behaviours as assessed by the childhood behaviour checklist (cbcl). * clinically assessed self-injurious behaviour • low intrinsic motivation to participate in a social skills training group * insufficient english language skills

Keywords: social groups active contol group children australian
phase iii study to evaluate the immunogenicity and safety of mg1109 in healthy adult volunteers

Conditions: Influenza

Summary: the purpose of this study is to evaluate the immunogenicity and safety of the investigational vaccine in the subjects during their participation in the study.

mg1109 is purified, inactivated influenza viral antigen.

Eligibility criteria:
inclusion criteria: * healthy adults who are available for follow-up during the study exclusion criteria: * subjects with history of exposure to the h5n1 subtype or h5n1 subtype vaccine * subjects with immune system disorder including immune deficiency disease

Keywords: avian influenza
adrenocorticotropic hormone stimulation in postural orthostatic tachycardia syndrome (pots)

Conditions: Postural Tachycardia Syndrome

Summary: this study is to determine different chemical levels in the blood during a low salt diet. this study will compare normal volunteers to those with postural tachycardia syndrome (pots)

patients with postural tachycardia syndrome had a subnormal increment in aldosterone with upright posture, which might reflect a blunted adrenal response to stimulation upon assuming upright posture. in this aim, we propose to assess the adrenal response to aldosterone stimulation with intravenous adrenocorticotropin hormone. for this protocol, subjects enrolled in the parent study will be approached about this sub-study. subjects will be assured that they are not required to participate in this study even if they choose to participate in the parent study. there will be no randomization for this specific sub-study. the order of diets (low sodium vs. high sodium) will be performed as a part of the parent study, and not as a part of this sub-study. this sub-study will only be performed in the low dietary salt phase. all subjects will be previously screened and evaluated as a part of the parent study. no further screening will be performed exclusively for this study. women of childbearing potential will have had a serum pregnancy test as a part of the parent study. pregnant women will not be allowed to participate.

Eligibility criteria:
inclusion criteria: subjects will be enrolled in the parent study "dietary salt in postural tachycardia syndrome" during the "low salt" phase postural tachycardia syndrome diagnosed with postural tachycardia syndrome by the vanderbilt autonomic dysfunction center increase in heart rate ≥30 beats/min with position change from supine to standing (10 minutes) chronic symptoms consistent with pots that are worse when upright and get better with recumbence * control subjects * healthy, non-obese, non-smokers without orthostatic tachycardia * selected to match profiles of pots patients (gender, age) * not using vasoactive medication * age between 18-50 years * male and female subjects are eligible. * able and willing to provide informed consent exclusion criteria: * overt cause for postural tachycardia (such as acute dehydration) * inability to give, or withdrawal of, informed consent * pregnant * other factors which in the investigator's opinion would prevent the subject from completing the protocol.

Keywords: pots
taurine eye drops may prevent the progression of cataract

Conditions: Cataract

Summary: the aim of the current intervention study is to determine the effectiveness of taurine containing eye drops (available under brand name viziloton) to prevent the progression of grade i and ii senile cataract. this study could answer: * dose continuous use of taurine-containing eye drops could prevent further deterioration of vision in mild cases of cataract? * the acceptance/ compliance of participants to taurine-containing eye drops. * could long-term use of taurine-containing eye drops cause adverse effect(s)? participants will: * take taurine-containing eye drops (viziloton eye drops) 4 times a day for one year. * visit eye clinic every 3 months for assessment and visual examination. * keep notes for their symptoms and their adherence to treatment.


Eligibility criteria:
inclusion criteria: * the presence of grade i or ii senile cataract on one or two eyes. exclusion criteria: * clinical signs of glaucoma * history of amblyopia, eye surgery, argon or yag laser eye treatment, or major eye trauma * history of iritis, retinal crystalline deposits, or optic nerve disease * visually significant fundus pathology
a phase i study to evaluate the safety, tolerability, pharmacokinetics ，pharmacodynamics of oral shr2150 in healthy subjects

Conditions: HIV-1 Infection

Summary: the study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability and pharmacokinetics, pharmacodynamics of shr2150. will consist of 50 healthy subjects, 5 groups. the purpose of this part is to explore the safety, tolerability ,pharmacokinetics and pharmacodynamics of single doses of shr2150 capsule in healthy subjects.


Eligibility criteria:
inclusion criteria: 1. signed informed consent. 2. aged 18\~45. 3. body weight ≥ 50 kg for male; ≥ 45 kg for female, body mass index (bmi) between 18 to 28 kg/m2 ( including boundary value) . 4. vital signs, physical examination, laboratory results are within normal range or considered not clinically significant. 5. female subjects (including partner) of childbearing potential must be using a medically acceptable form of birth control. exclusion criteria: 1. currently suffering from cardiovascular, liver, kidney, digestive, nervous, blood, thyroid or mental diseases. 2. have severe infection, severe trauma or major surgical operations within 3 months. plan to receive surgery during the trial and within two weeks after the end of the trial.. 3. 12-ecg test have clinical significant abnormality or the qt interval (qtc) \> 450 ms(male)/qtc)\> 460 ms(male) or\<300ms(female). 4. screening for infectious diseases is positive (including hbsag, anti-hcv, tppa, anti-hiv) 5. suspected allergy to any ingredient in the study drug. 6. have any drug that inhibits or induces liver metabolism within 1 month. 7. any condition or disease that affects the absorption, metabolism, and/or excretion of the study drug judged by the investigator; 8. treatment with immunosuppressant or interferon-containing drugs within 6 months of study drug administration; 9. participated in clinical trials of any drug or medical device within 3 months before screening, or within 5 half-lives before screening; 10. treatment with live(attenuated) vaccine within 2 months before taking the study drug or during the study or within 1 months after administration; 11. had donated blood or blood transfusion≥ 200 ml within 1 months before taking the study drug or had donated blood or blood transfusion≥ 400 ml within 3 months prior to screening; 12. the average daily smoking ≥ 5 cigarettes within three months; the average daily alcohol intake in a month exceeds 15 g (15 g alcohol is equivalent to 450 ml beer or 150 ml wine or 50 ml low-alcohol); 13. keep smoking, drinking alcohol or consuming caffeinated foods or beverages (more than 8 cups, 1 cup = 250 ml) 2 days before taking the study drug and during the study; and those who have special dietary requirements and cannot follow the unified diet; 14. history of drug abuse , drug dependence or drug screening test is positive; 15. pregnant or lactating women; 16. other conditions that the investigator believes the subject is not suitable.
an extension study of kps-0373 in patients with spinocerebellar degeneration (scd)

Conditions: Spinocerebellar Degeneration

Summary: the purpose of this study is to evaluate the long-term safety, efficacy, and pharmacokinetics of kps-0373 in scd patients.


Eligibility criteria:
inclusion criteria: * japanese scd patients with mild to moderate ataxia (completion of the kps1301 study) exclusion criteria: * less than 75% of compliance in kps1301 study

Keywords: spinocerebellar degeneration (scd) thyrotropin-releasing hormone (trh) spinocerebellar ataxia (sca) cortical cerebellar atrophy (cca)
topical antibiotic prophylaxis for eyelids

Conditions: Antibiotic Side Effect; Eyelid; Wound; Eyelid Diseases; Surgical Wound Infection; Surgical Wound, Recent; Surgical Incision; Skin Cancer Face; Antibiotic Allergy; Surgical Site Infection

Summary: the investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery.

the use of prophylactic topical antibiotic therapy after eyelid surgery is widespread. due to increasing antibiotic resistance, antibiotic-related complications, and healthcare costs, the investigators wish to determine whether prophylactic post-operative antibiotic ointment is truly necessary. after all, existing dermatology literature currently recommends against the routine use of antibiotic ointment after various surgical procedures (e.g. mohs surgery). the investigators aim to perform a prospective randomized control trial at the university of california, san francisco. the investigators aim to recruit a total of 400 oculoplastics patients undergoing eyelid surgery or surgery involving peri-orbital incisions from 2017 through 2019.

Eligibility criteria:
inclusion criteria: patients aged 18 and older who are undergoing various eyelid procedures in an office, ambulatory care center, or operating room including but not limited to: * blepharoplasty (upper and lower lids); * ectropion repair; * entropion repair; * external dacryocystorhinostomy; * external levator resection; * eyelid lesion removal and/or biopsy; * eyelid reconstruction and defect repair including after mohs surgery; * fat pad excision (upper and lower lids); * gold or platinum weight implantation; * internal levator resection; * lateral tarsal strip; * orbital fracture repair requiring periorbital incisions; * orbitotomy requiring periorbital incisions; * tarsorrhaphy; * wedge excision. * patients undergoing repeat procedures will also be included. exclusion criteria: * patients aged younger than 18 years old who are undergoing the above eyelid procedures in an office, ambulatory care centers, operating rooms; * patients undergoing chalazion removal; * patients who have had previous wound infections at the site of the procedure; * patients with oral or iv antibiotic use within 10 days prior to procedure; * patients requiring iv antibiotics during the procedure; * patients with grossly contaminated or inflamed wounds; * patients with human or animal bites, patients with wounds resulting from trauma * patients allergic to all study drug options.
effect of infraclavicular and interscalen block on oxygenitaon of the forearm

Conditions: Upper Extremity Fracture

Summary: to research the oxygenitaon effects of infraclavicular and interscalene blocks on the forearm.

to research the oxygenation effects of infraclavicular and interscalen blocks on the forearm by comparing the blood flow (bf) values using the usg, perfusion index (pi) and near infrared spectroscopy (nirs) values using the massimo device.

Eligibility criteria:
inclusion criteria: * aged between 18-65 * asa score i-iii * undergoing elective or emergency arm, elbow and forearm surgery exclusion criteria: * patient's refusal for brachial plexus blockage * patients who had any neurological disorders preventing the evaluation of the sensory block in the upper extremity, * infection in the area to be blocked with icb or isb, * non-cooperated patients * patients with coagulopathy, * morbidly obese patients * patients with diabetes mellitus * patients with hypertension * patients with peripheral artery disease * patients with allergy to the drugsto be used * patients who had trauma in the area scheduled for the block * paitens who had deterioration of anatomical integrity because of previous surgery * pregnant women * patients whose block failed