Kornimate/medical-research-clean huggingface dataset:
preservation of pancreatic beta cell function through insulin pump therapy

Conditions: Diabetes Mellitus

Summary: type i diabetes (t1dm) is the second most common chronic illness effecting children in the usa. worldwide, type i diabetes is increasing in incidence, and its underlying etiology remains elusive. nevertheless, recent data supports the notion that early and intensive management of type i diabetes can 1) decrease long-term complications of diabetes; and 2) may significantly improve beta cell function and insulin secretion over ensuing years. to this end, we propose using insulin pump therapy to preserve and/or enhance residual endogenous b-cell secretory capacity among patients with newly diagnosed type 1 dm. furthermore, we anticipate that early use of an insulin pump will improve glycemic control beyond that achieved with standard multiple daily injection (mdi) therapy, and will be well-tolerated by the patient. these data will provide important pilot information to explore the potential role of intensive insulin pump therapy in the treatment of children newly diagnosed with type i diabetes. the specific aim of this study is to test the following hypothesis: early use of insulin pump therapy is effective in preserving or enhancing residual endogenous pancreatic b-cell secretory capacity among patients with newly diagnosed t1dm: moreover, early use of an insulin pump will improve glycemic control beyond that achieved with standard multiple injection therapy, and will be well-tolerated by the patient.


Eligibility criteria:
inclusion criteria: * medical history and clinical presentation consistent with the diagnosis of type 1 dm. * age: 8-18 years exclusion criteria: * clinical presentation consistent with type 2 dm. * history of other chronic systemic inflammatory or autoimmune disease or other severe medical conditions. * concurrent pregnancy. * participation in other research protocols or use of other investigational agents within 30 days of enrollment.

Keywords: insulin pump beta cell
mobile health intervention in intracerebral hemorrhage survivors

Conditions: Intracerebral Hemorrhage; Hypertension

Summary: this randomized controlled trial investigates the efficacy and safety of mobile health intervention in managing hypertension after intracerebral hemorrhage (ich).

140 ich survivors will be randomized into mobile health intervention (mobile) and the usual care group for hypertension management. all subjects will be educated on the importance of hypertension control after ich and given lifestyle advice, including the dash diet. subjects in the mobile group will enter their home blood pressure (bp) measurements into a mobile stroke app (werise) daily, and the study team will regularly review the bp measurements through a backend system. a protocol-based intervention via phone calls, which includes anti-hypertensive drug adjustment and reinforcement of lifestyle modification, will be implemented. subjects in the usual care group will have their hypertension managed by their respective treating physicians. all subjects will be followed up for 26 weeks. the primary and secondary endpoints include the rate of controlled hypertension at 12 and 26 weeks.

Eligibility criteria:
inclusion criteria: * primary ich diagnosis * age ≥ 18 years * discharge modified rankin scale of ≤4 exclusion criteria: * expected life expectancy of \<1 year * patient or caregiver does not have access to werise app. * patient or caregiver does not know how to use werise app . * inability to perform home bp monitoring * inability to participate in follow-up activity * contraindication for intensive and rapid lowering of blood pressure (known \>70% cerebral vascular stenosis; history of fall, dizziness or syncope due to hypotension; any other medical condition that is deemed contraindicated for low blood pressure * bleeding tendency (platelet count \< 75 x 10\^9/l; known coagulation disorder) * severe renal impairment (estimated glomerular filtration rate using ckd-epi formula \<30 ml/min/1.73m2) * severe liver impairment (child-pugh c cirrhosis) * known contraindication or allergy to two or more anti-hypertensive classes
a study of second look laparoscopy (sll) in people with ovarian cancer who have completed their first course of chemotherapy

Conditions: Ovarian Cancer

Summary: the researchers are doing this study to look at the health outcomes of people with advanced ovarian cancer who have a second look laparoscopy (sll) after they complete their first course of chemotherapy. the researchers will compare the health outcomes of people who have minimal residual disease (mrd-small amounts of cancer cells in the body after a person receives treatment) at the time of sll with the health outcomes of people who do not have mrd at the time of sll. the researchers are also doing this study to determine if sll is safe and practical (feasible) in people with advanced ovarian cancer who have completed the first course of therapy for their disease.


Eligibility criteria:
inclusion criteria: * patients assigned female at birth≥ 18 years of age * suspected or known stage iii-iv epithelial ovarian cancer for which the patient has undergone, or is planned to undergo, attempted primary or interval debulking surgery * homologous recombination deficiency testing should be planned to be completed prior to completion of initial platinum/taxane chemotherapy. hrd testing can be determined using : * confirmation of deleterious somatic or germline brca mutation * clia certified test for hrd * patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial exclusion criteria: * patients with the inability to swallow oral medications or impaired gastrointestinal absorption due to gastrectomy or drainage gastrostomy tube * patients receiving standard of care or investigational protocol directed treatment are eligible for this study, with the exception of protocol directed treatment which would prohibit the sll surgery from being performed

Keywords: stage iii-iv epithelial ovarian cancer second look laparoscopy (sll) 23-249
factors predicting the duration of effectiveness of viscosupplementation in knee arthosis

Conditions: Knee Osteoarthritis

Summary: knee osteoarthritis is a frequent condition whose prevalence is estimated at 7.6% of the french population aged 40 to 75, or approximately 2 million individuals . viscosupplementation (vs) is a symptomatic treatment of knee osteoarthritis recommended by a large number of learned societies. it consists of the intra-articular injection (ia) of hyaluronic acid (ha), to reduce knee pain by restoring normal joint homeostasis impaired by endogenous ha deficiency. the ia administration of ha can be performed using 2 protocols: repeated weekly injections (3, sometimes 5 injections) and single injections. to date and there is no argument to favor either protocol. regardless of the formula used, the safety of ha is excellent (rr of adverse reaction versus saline = 1.01, 95% ci 0.96-1.07, p = 0.6). the indication for viscosupplementation is the symptomatic treatment of mild to moderate knee osteoarthritis after failure and / or intolerance of analgesics or nonsteroidal anti-inflammatory drugs (nsaids). in this indication, after ha injection the responder rate is in the order of 70% to 75% at 6 months and approximately 50% at 12 months. however, the predictors of the duration of effectiveness of sv are still unknown. the objective of the study is to research the factors influencing the duration of the effectiveness of sv, under real life conditions.


Eligibility criteria:
inclusion criteria: * all adult outpatients, of both sexes, regardless of age, with a doctor-accepted diagnosis of knee oa and who have been treated with sv within the past 3 years exclusion criteria: * patients who have not been treated with sv in the past 3 years. * patients who have been treated with vs for an indication other than osteoarthritis of the knee. * patients in whom the assessment could not be performed reliably

Keywords: viscosupplementation
illness management and recovery (imr) in danish community mental health centres

Conditions: Schizophrenia; Bipolar Disorder

Summary: the aim of this trial is to evaluate the effectiveness of the illness management and recovery program for people diagnosed with schizophrenia or bipolar disorder in according to their level of functioning.

background: illness management and recovery (imr) is a curriculum-based psychosocial intervention designed as structured program with a recovery-oriented approach. the aim of imr is to rehabilitate people with severe mental illnesses by helping them acquire knowledge and skills in managing their illness and achieve personal recovery goals. previous randomised clinical trials indicate that imr can be implemented with a good effect and a high fidelity though further trials are crucial to demonstrate the potential effectiveness of imr. methods/design: the trial design is a randomised, assessor-blinded, multi-centre, clinical trial of the imr program compared with treatment as usual for 200 participants diagnosed with schizophrenia or bipolar disorder under the care of two community mental health centres in the capital region of denmark. the primary outcome is level of functioning at the end of treatment and at follow-up 21 months after baseline. the secondary outcomes are disease symptoms; use of alcohol/drugs; individual meaning of recovery; hope; hospital admissions and out-patient psychiatric treatment at the end of treatment and at follow-up 21 months after baseline.

Eligibility criteria:
inclusion criteria: * adults (age 18+) * both sexes * associated with one of the two participating community mental health centres * diagnosed following the icd-10 criteria of schizophrenia or bipolar disorder * able to speak and understand danish * giving informed consent verbally and in writing exclusion criteria: * have a guardian or a forensic psychiatric arrangement * comorbidity with the icd-10 criteria of the diagnoses of dementia or mental retardation * a large-scale substance abuse - if later on the abuse is under control inclusion in the trial will be possible * a current home of supported housing - since the treatment as usual given to this group of patients is significant different from patients living independently * a current involvement in a psycho-educational course - patients are eligible for participation in the trial after the psycho-educational course has ended if they meet the inclusion criteria at this point * not given informed consent.

Keywords: recovery illness management rehabilitation mental illness psychosocial intervention clinical recovery (increase in functioning, decrease in symptoms) personal recovery (hope, optimism, living a fulfilling life)
camp smart speech to print summer literacy camp

Conditions: Reading Disorder, Developmental

Summary: this project aims to explore the feasibility and efficacy of a 6-week, intensive summer literacy intervention provided to children in 1st-3rd grades.

1. purpose/objective: to determine the feasibility and preliminary effectiveness of a 6-week literacy summer camp for improving language and literacy outcomes of children with identified language or literacy difficulties. 2. methods: this intervention will be provided by students in the speech and hearing clinic on sdsu's campus. the summer clinical sessions last for 8 weeks. week 1 will be used for the pre-testing of each participant's baseline language (morphological awareness, phonological awareness, morphosyntax, vocabulary, and narrative language skills) and reading (letter knowledge, nonword reading, reading fluency and reading comprehension). in weeks 2-7, the intervention will take place. this will consist of 3, 3-hour sessions per week. finally, in week 8, the investigators will conduct post-testing of children's language and reading skills. 3. subjects: the investigators will recruit a maximum of 12 students who are in the summer after kindergarten, first, or second grade. the investigators will be recruiting students from the local community who either a) have ieps with eligibility of sli or sld-reading or b) have documented parent or teacher concern for reading and/or language skills as determined by parent questionnaire. 4. planned analyses: planned analyses will include analysis of improvement in each of the language and reading skills from pre-test to post-test. the investigators will also include probes of performance of reading skills to allow for single subject analysis. the investigators will develop fidelity rubrics to explore the fidelity of intervention implementation and will analyze how fidelity relates to individual-child-level improvement.

Eligibility criteria:
inclusion criteria: * students who are in the summer after kindergarten, first, or second grade. * students from the local community who either a) have ieps with eligibility of sli or sld-reading or b) have documented parent or teacher concern for reading and/or language skills as determined by parent questionnaire. * children who fit the above criteria will additionally be determined eligible for the intervention based on language or reading composite skills one or more standard deviations below the mean on the test of integrated language and literacy skills (tills). * children who are rising 4th, 5th, or 6th graders and who have an iep with eligibility of sli or sld-reading and who demonstrate composite scores one or more standard deviations below the mean on the tills may be considered if space remains after recruitment of 1st-3rd graders. exclusion criteria: * students who do not either a) have an iep or b) have documented parent or teacher concern based on parent questionnaire. * students who score within the typical range on the tills. * students who are deaf or blind.

Keywords: literacy intervention
the benefit of functional movement control for patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the study purpose is to explore the effect of functional movement control for patients who have stage ii or iii degenerative knee joint disease and also physical inactive. half of patients will receive aerobic exercise and functional movement control training in combination, while the other will simply receive aerobic exercise.

physical inactivity, which is a common phenomenon among patients with degenerative knee joint disease has been proved a predictor of increased symptoms and poor general health. however, changing the lifestyle of people with this disease who is physical inactive is still a problem which has not been solved. knee pain may act as barrier to engage in physical activity and can influence patient's movement performance. the different effectiveness between the aerobic exercise and functional movement control training. aerobic exercise has been proved could improve knee pain for the patients with degenerative knee joint disease. the functional movement control training could improve knee alignment during walking and other functional activities to increase patient's movement awareness.

Eligibility criteria:
inclusion criteria: * participant who was diagnosed has knee osteoarthritis * above 40 years old * participant who didn't achieve at least 150 min moderate intensity physical activity level per week exclusion criteria: * patients with walking disability * cannot complete 8 weeks intervention program * received arthroscopy or other surgery before 6 months

Keywords: knee osteoarthritis physical activity exercise
a randomized, clinical trial of oral midazolam versus oral ketamine for sedation during laceration repair.

Conditions: Lacerations

Summary: sedation is often needed for young children undergoing minor procedures in the emergency department (ed). oral midazolam is one of the most commonly used regimens for children undergoing laceration repair but its sedative efficacy was shown to be suboptimal. in only one randomized controlled study oral ketamine has been used successfully for procedural sedation for laceration repair. a recent study showed that the combination of oral midazolam and oral ketamine provided deeper sedation compared with oral midazolam alone. however children treated wuth the combination of midazolam and ketamine required longer recovery hypothesis: oral ketamine can provide superior sedation to oral midazolam in children requiring sedation for laceration repair.


Eligibility criteria:
inclusion criteria: • any child with laceration requiring sedation exclusion criteria: * major trauma * closed head injury associated with loss of consciousness * abnormal neurologic examination in a previously normal child * significant developmental delay or baseline neurological deficit * a patient with seizures * elevated intra-cranial pressure * hypersensitivity to midazolam or ketamine * hypertension * hyperthyroidism or a patient receiving thyroid replacement * alcohol intoxication or a history of alcohol abuse * acute or chronic respiratory, cardiac, renal or hepatic abnormalities * glaucoma * known psychiatric disease * american society of anesthesiologists (asa) score of more than 2 * informed consent cannot be obtained from legal guardian

Keywords: laceration sedation pediatrics
success of endodontic treatment with different obturation techniques and sealer cements

Conditions: Pulpitis; Periapical Lesions; Periapical Periodontitis; Periapical Pathology

Summary: the present study aims to compare the radiographic success of endodontic treatment using orstavik's criteria between two sealers: ah plus (dentsply detrey, konstanz, germany) and neosealer flo (avalon biomed, bradenton, florida, usa), as well as between two obturation techniques: continuous wave and single cone. the study includes 270 patients, with a minimum follow-up period of 6 months. clinical and radiographic variables will be assessed, including quality of obturation, lesion healing, and restoration. the study seeks to determine if the use of bioceramic sealer is effective regardless of the obturation technique used, highlighting the importance of clinical follow-up to evaluate endodontic treatment success.


Eligibility criteria:
inclusion criteria: patients aged 18 years and older. teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. informed consent provided for data usage. exclusion criteria: * patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression). * teeth with root fractures, resorption, or open apices. * incomplete clinical or radiographic records. * cases with poor-quality radiographs or lack of standardization for evaluation

Keywords: endodontics endodontic sealer calcium silicate-based sealer ah plus
colchicine in atrial fibrillation to prevent stroke

Conditions: Atrial Fibrillation; Stroke

Summary: the purpose of this study is to determine the feasibility of performing a randomized controlled trial to investigate the efficacy of an anti-inflammatory drug, colchicine, at reducing well validated markers of thrombosis (d-dimer) and inflammation (hs-crp).

atrial fibrillation (af), the most common cardiac arrhythmia (with a global burden of 33.5 million affected patients in 2010), is responsible for about 20% of ischemic stroke, a major cause of morbidity and mortality. anticoagulants are very effective in reducing the risk of stroke in af but on average 10-15% of treated patients still experience a stroke over a 10-year period and in selected elderly populations the risk is even higher. we hypothesize that thrombosis mediated by inflammation might be responsible for the residual risk of stroke, despite anticoagulant therapy and that targeting inflammation has the potential to reduce thrombosis and the risk of stroke in anticoagulated patients with af.

Eligibility criteria:
inclusion criteria: * patients with atrial fibrillation who has been receiving chronic anticoagulation for at least 3 months. exclusion criteria: * contraindications to colchicine such as allergy/hypersensitivity, * receiving colchicine or other anti-inflammatory drugs (such as corticosteroids, methotrexate, anti-neoplastic, interleukin 1-1b antagonist, tumor necrosis factor-alpha inhibitor), * receiving food or co-medications such as strong-moderate cytochrome p450 3a4 inhibitors that will result in elevated plasma level of colchicine, * inflammatory disorders (sle, rheumatoid arthritis, connective tissue disorder) or chronic infection, * severe renal (egfr\ 2x upper limit of normal), * moderate or severe cytopenias (platelet \< 100, neutrophil count \< 1.5) or existing blood dyscrasia (e.g., myelodysplasia) * pregnant or lactating woman or woman of child bearing age no protected by reliable contraception.

Keywords: atrial fibrillation arrhythmias, cardiac stroke agents, anti inflammatory d-dimer c-reactive protein
evaluation of balance and functionality in postmenopausal osteoporosis using quadriceps femoris muscle thickness, beyond thoracic hyperkyphosis

Conditions: Osteoporosis; Sarcopenia; Ultrasonography; Hyperkyphosis

Summary: to determine the impact of thoracic hyperkyphosis, sarcopenia and quadriceps muscle thickness evaluated by ultrasonography (usg) on balance, fall risk and functional parameters in women with postmenopausal osteoporosis, to assess their interrelationships and to compare the clinical characteristics of sarcopenia and thoracic hyperkyphosis.

an observational study was conducted on patients with pmo and/or osteoporotic vertebral fractures according to who criteria. one hundred seventeen patients who were 50 years of age or older, with a diagnosis of pmo and/or osteoporotic vertebral fractures according to who criteria, who were able to ambulate without any assistive devices were included in the study. patients with a history of neurological disease which may affect balance and proprioception, visual and vestibular disease, previous major lower extremity surgery or previous vertebra surgery were excluded. the investigators also excluded the patients with advanced heart, liver, or renal failure, stage 4 knee osteoarthritis, psychiatric disorders, and use of any medication affecting the central nervous system. age, height, weight, body mass index (bmi), comorbidities, medications, previous surgeries, steroid use, previous fractures and the energy level of these fractures (low or high), fracture location, family history of fractures, alcohol use, smoking, menopausal age and the number of falls in a year were questioned. the frax algorithm was used to determine the risk of fracture. the cobb angle of thoracic kyphosis was calculated radiographically and qfm thickness was measured from anterior thigh via ultrasonography (usg). the presence of sarcopenia was determined. balance, fall risk and physical function were evaluated with tandem stance and gait test, berg balance scale (bbs), timed up and go test (tug), hand grip strength, chair stand test (cst).

Eligibility criteria:
inclusion criteria: * patient who were 50 years of age or older, had postmenopausal osteoporosis and/or osteoporotic vertebral fractures according to who criteria, * patient who were able to ambulate without any assistive devices exclusion criteria: * history of neurological disease which may affect balance and proprioception, * visual and vestibular disease * previous major lower extremity surgery or previous vertebra surgery * advanced heart, liver, or renal failure * stage 4 knee osteoarthritis * psychiatric disorders * use of any medication affecting the central nervous system.

Keywords: muscle thickness sarcopenia hyperkyphosis ultrasonography