Kornimate/medical-research-clean huggingface dataset:
prostate metabolism, cancer risk and gut microbiota

Conditions: Prostate Cancer; Prostate Hyperplasia

Summary: this is a prospective, single center translational multiple cohort study to investigate the association of gut microbiota and prostate cancer.

prostate cancer (pca) is a significant health care system challenge. pca is the most common male cancer in finland and most western countries. interestingly, although the incidence of indolent (latent) pca is very similar throughout the globe, there is a remarkable global age-adjusted incidence variation (up to 40-fold difference between highest and lowest incidences). epidemiological data suggest that aging in men is associated with neoplastic processes in the prostate but only a subset of men will develop a true malignancy potentially affecting their life-span or quality of life. genetic factors have a significant effect on pca risk, but very likely life-style (e.g. diet and physical activity) affect pca risk as well, but the mechanisms mediating protective or harmful effects of life-style remain unclear. gut microbiota, i.e. the collection of microbes colonizing the gastrointestinal tract, has been acknowledged to play significant role in many metabolic pathways and pathogenetic processes in the human body. although there is some evidence suggesting that gut microbiota affects therapy responses (especially androgen deprivation) in pca, it´s potential role in prostate carcinogenesis is not well documented. our previous studies suggest that gut microbiota composition is different in men with and without pca potentially contributing to the pca risk, and that changes in steroid hormone synthesis may be one mechanism how gut microbiota affects pca risk. promic is a prospective, single center translational multiple cohort study to investigate the association of gut microbiota and pca. the main aim is to validate our preliminary findings of association between gut microbiota and pca. we also study metabolic characteristics in the gut, systemic circulation, and prostate tissue in men with different gut microbiota signatures. the study is carried out in turku university hospital and university of turku.

Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form. * ability and stated willingness to comply with all study procedures and availability for the duration of the study. exclusion criteria: * inability to comply with study procedures or unwillingness to participate in the study.
fibrin monomer compared with hemostatic sponge in the integrity of the graft during tympanoplasty

Conditions: Tympanic Membrane Perforation

Summary: the diagnosis of tympanic perforation reaches a high number of records in otorhinolaryngology services worldwide. most of the tympanoplasties are performed in patients whose cause of perforation and hearing loss was chronic otitis media; this entity affects the population between 0.5 to 30% , the statistics mention more than 20 million people with this disease in the world. since the introduction of tympanoplasty in the second half of the nineteenth century there have been numerous publications nationally and internationally about various experiences and new techniques. including the use of fibrin monomer . this procedure is usually performed with the use of hemostatic sponge and recently with fibrin monomer, both materials are part of the basic input and surgical hemostatic agents. in this hospital are performed on average 110 tympanoplasty per year which has a percentage of non- integrity of the graft in the case of microscopic tympanoplasties using hemostatic sponge of 16% which is similar to the index of lack of integrity of the graft in microscopic tympanoplasties reported worldwide (18%), with the recent addition to the service of fibrin monomer, was necessary to evaluate if this material contributes to the integrity of the graft in microscopic tympanoplasty, as it has been reported in previous studies, so if there is found more integrity with this material, it can be recommended for routine use, improving the final prognosis of the patients.

objective: assess the effect of fibrin monomer in the integrity of the graft during tympanoplasties compared with the effect of the hemostatic sponge at the hospital of specialties western medical center. material and methods: clinical trial with single blind, parallel-groups and randomized assignation. there were included patients with a diagnosis of tympanic perforation, candidates for surgical treatment by performing only microscopic tympanoplasties, which fulfilled the selection criteria. the main variable of the study was the integrity of the graft. the statistical analysis was performed according to the nature of variables, for continuous data using measures of central tendency and dispersion and for the qualitative data with frequencies and percentages. to evaluate the effect of fibrin monomer relative to the hemostatic sponge, the data relating to the integrity of the graft between the groups were analyzed by chi-square.

Eligibility criteria:
inclusion criteria: * patients diagnosed with tympanic perforation and with surgical indication of tympanoplasty (without otorrhea for 6 months) exclusion criteria: * background of tympanic perforation caused by allergic or pulmonary diseases including asthma and allergic rhinitis.

Keywords: fibrin monomer tympanoplasty hemostatic sponge
comparison of mucin levels at the ocular surface of visual display users with and without dry eye disease

Conditions: Dry Eye Disease

Summary: the study aimed to evaluate 1) if levels of the glycocalyx membrane mucins, including muc1, muc4, muc16 and muc20, are altered in conjunctival cells of visual display users with and without dry eye disease, and 2) if mucin levels correlate with dry eye clinical diagnostic data.

the cross-sectional study aimed to evaluate 1) if levels of the glycocalyx membrane mucins, including muc1, muc4, muc16 and muc20, are altered in conjunctival cells of visual display users with and without dry eye disease, and 2) if mucin levels correlate with dry eye clinical diagnostic data.

Eligibility criteria:
inclusion criteria: * participants who exposed to video display terminals for more than 1 year (at least 5 days per week and 6 hours per day) were enrolled and divided into two groups: (1) vdt users with ded and (2) vdt users without ded. ded was diagnosed according to the tear film and ocular surface society (tfos) dews ii criteria: (1) ocular surface disease index (osdi) score ≥ 13 and (2) one of these signs; fluorescein tear breakup time (tbut) \ 5 corneal spots or \> 9 conjunctival spots). exclusion criteria: * a history of contact lens wear or ocular surgery within 2 year of the study visit; a history of previous ocular disease; topical or systemic therapies other than artificial tears within two weeks before recruitment; and inflammatory ocular diseases, ocular surface diseases, glaucoma and systemic diseases with ocular involvement, such as meibomian gland dysfunction, diabetes, and peripheral neuropathy.

Keywords: dry eye disease mucin
effectiveness of brief intervention in primary care for diverse young people (chat)

Conditions: Adolescent Drinking; Cannabis Use

Summary: brief motivational interviewing intervention to address alcohol use among diverse teens 12-17.

the six-item crafft will be used to screen teens at our partner clinics for risky ac use. for those that screen in as at-risk and express interest in the study, the teen's case manager will complete an online consent/assent form with the parent and teen that contains contact information for the teen so that investigators can follow up with the teen for surveys and intervention delivery or for providing an informational brochure. when the online consent/assent form is completed, the teen will be sent a personalized link to complete their baseline survey. upon survey completion, the teen will receive a link that has their electronic gift card payment, and the case manager will be notified that a particular id has completed the survey. the case manager will be informed by study staff whether to schedule that id for enhanced usual care (euc) or the chat intervention. investigators expect each teen to be scheduled within 30 days of completing their baseline survey to receive euc or chat. the informational brochure for the euc will be handed to the teen during the visit or securely emailed, and chat could take place either via a virtual or in-person visit. whether or not the teen completes euc or chat, every teen will be followed by the rand survey research group to complete their follow-up web-based surveys based on timing of completion of their baseline survey. teens will receive gift card incentives for completing the 3-month, 6-month, and 12-month surveys. investigators will begin recruitment in month 9 of the project. briefly, investigators expect to recruit from study month 9 to month 42 for the baseline survey. investigators expect the chat intervention to occur from months 9 to 42 the 3-month follow-up from months 12 to 45, 6-month from months 15 to 48, and the 12-month from months 21 to 53. out of an anticipated 5,644 clients that our partner clinics will screen, investigators expect approximately 847 (15%) to screen in as at-risk on the crafft and anticipate that approximately 500 (\~60%) will consent into the study.

Eligibility criteria:
inclusion criteria: * receive health care at one of two participating health systems * aged 12-17 * screen positive for being at risk for alcohol or cannabis use using the crafft exclusion criteria: * if they don't meet the inclusion criteria, they will be excluded
diffusion tensor imaging in chronic inflammatory demyelinating polyneuropathy (pidc)

Conditions: CIDP (Chronic Inflammatory Demyelinating Polyradiculoneuropathy); CMT (Charcot Marie Tooth Disease)

Summary: the main purpose of this study is to assess the clinical feasibility of diffusion tensor imaging (dti) for the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (cidp). for thar purpose, investigator will compare, fractional anisotropy (fa) obtained by diffusion tensor imaging (dti) mri 3t on brachial plexus and cervical spinal nerve roots between patients with defined chronic inflammatory demyelinating polyradiculoneuropathy (cidp), according to the efns 2010 criteria, and healthy controls. the secondary outcomes will be to compare dti parameters (fa, adc or apparent diffusion coefficient) between cidp patients, healthy volunteers, and patients with charcot marie tooth disease type 1a (cmt1a) and mri morphological parameters (t1, stir) between these groups. moreover, investigator will investigate the possible relationship between mri parameters, clinical indices, and electrophysiological measure.

investigator will prospectively enroll 15 patients with cidp followed in the neurology department of clermont ferrand university hospital, who satisfy the joint task force of the efns and pns definite cidp criteria. two control groups will be studied in parallel, including 15 healthy volunteers on one side, and 15 patients with cmt-1a on the other side (proven by genetic testing). using a 3-t magnetic resonance imaging scanner, we will obtain dti scans of brachial plexus of these 3 groups, prepare fractional anisotropy (fa) maps, and compare these values between groups. investigator will evaluate mri imaging findings too (coronal stir, t1-weighted images,and dwis). mri studies will be reviewed independently by two neuroradiologists, blinded to clinical informations. in all patients with cidp, investigator will also performs clinical evaluation and electroneuromyography. correlation between fa values clinical indices will be examined.

Eligibility criteria:
inclusion criteria: * - for all patients: at least 18 years-old. * for cmt1a group : cmt1 a should be proven by genetic testing * for cidp group: cidp should satisfied the definite cidp criteria of the joint task force of the efns and pns 1 (situations a and b according to the french cidp work group2). they might have received steroids, immunoglobulin or immunosuppressive treatments exclusion criteria: * for all groups: any neurological comorbidity, other causes of neuropathy or history of exposure to neurotoxic agents (the inclusion and exclusion criteria are detailed in supplemental data) allergies, renal failure, pregnancy

Keywords: feasibility and reproductibility dti parameters (fractional anisotropy, apparent diffusion coefficient) mri morphological parameters (t1, stir)
collection of blood, urine, and stool to monitor metastaticcolorectal cancers

Conditions: Stage III Colorectal Cancer AJCC v8; Stage IIIA Colorectal Cancer AJCC v8; Stage IIIB Colorectal Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8

Summary: this trial studies the monitoring of therapy and progression by collecting blood, urine, and stool from participants with colorectal cancer that has spread to other places in the body or cannot be removed by surgery. studying samples of blood, urine, and stool from participants with colorectal cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.

primary objectives: i. detection of mutated kras in urine specimen of patients with kras mutated metastatic colon cancer on first, second, or third line therapy. ii. detection of new kras in urine in patients without kras mutated metastatic colon cancer on therapy which includes anti-egfr antibodies (cetuximab or panitumumab). secondary objectives: i. changes of the stool microbiome with chemotherapy and at progression of the disease. descriptive objectives: i. changes in the quantity of mutated kras, braf or pi3k in urine deoxyribonucleic acid (dna) over the cycles of first line therapy. ii. associations between the quantity of mutated kras, braf or pi3k in urine dna, molecular make up of circulating tumor cells (ctcs), cell free dna and progression over the course of first line therapy. iii. feasibility of detection of exosome in the plasma of colorectal cancer patients on first line chemotherapy in dr. fabbri?s lab at children?s hospital los angeles. iv. feasibility of detection of tumor dna in the plasma of colorectal cancer patients on first line chemotherapy. outline: participants undergo collection of blood and urine at baseline, on day 1 of courses 1, 2, and 3, at restaging, and at disease progression. participants may undergo collection of stool at baseline, on day 1 of course 2, and at disease progression. participants also undergo biopsy within 4 weeks of disease progression.

Eligibility criteria:
inclusion criteria: * all patients with metastatic/unresectable colorectal cancer who will undergo first, second, or third line therapy; the participating investigator will select treatment, however, patients with kras wild type must receive anti-egfr therapy to be eligible for this study * subject consent to enrollment on the protocol * histologically confirmed metastatic or un-resectable colorectal cancer, known kras status; knowledge of other mutations is optional * willingness to undergo biopsy at the time of progression * willingness to follow the study instructions for collection of specimens * available archival tissue
the influence of thiopurine methyltransferase activity on toxicity after high-dose methotrexate in childhood acute lymphoblastic leukemia

Conditions: Acute Lymphoblastic Leukemia

Summary: the purpose of this study is to explore the impact of thiopurine methyltransferase (tpmt) activity on the risk of hdm-related bone marrow- and hepatotoxicity and treatment interruptions during maintenance therapy for children with all. hypothesis of the study: patients with tpmt activity compatible with tpmt low activity polymorphisms have an increased risk of toxicity following high-dose methotrexate (hdm) compared to children with normal tpmt activity.

high-dose methotrexate (hdm) given concurrently with oral 6-mercaptopurine (6mp) may be followed by myelotoxicity, which may necessitate treatment interruption and thus interfere with the efficacy of the treatment of childhood all. several studies have indicated that mtx and 6mp act synergistically. it has previously been reported that the risk of significant bone-marrow suppression is increased if oral 6mp is coadministered with hdm during maintenance therapy and that reductions of the dose of concurrently given oral 6mp can reduce the risk of significant myelotoxicity following hdm. mtx may increase the bioavailability of 6mp through inhibition of xanthine oxidase, which catabolizes 6mp. in addition, mtx may through inhibition of de novo purine synthesis enhance the availability of 6-thioguanine nucleotides (6tgn) that primarily exert the cytotoxic effect of 6mp. the enzyme tpmt competes with the formation of 6tgn, as it methylates 6mp and thus create relatively non-toxic metabolites. tpmt heterozygous patients with one wild type and one low-activity allele have a higher risk of myelosuppression and treatment interruption compared to patients with tpmt wild type. furthermore, tpmt heterozygous patients have a reduced risk of relapse and a higher risk of secondary malignancy compared to patients with tpmt wild type. little has been published on the influence of both tpmt activity and 6mp dosage on myelo- and hepatotoxicity following hdm.

Eligibility criteria:
inclusion criteria: * included in the nopho all92 protocol * available tpmt phenotype * treated at least once with hd-mtx 5.0 g/m2 (+- 10%) during maintenance therapy * at least one available measurement on blood counts or alanine aminotransferase levels 28 days after hd-mtx exclusion criteria: * hr all * children with down syndrome * events during maintenance therapy * tpmt deficiency

Keywords: acute lymphoblastic leukemia child 6-mercaptopurine methotrexate
continuous monitoring of vital signs at home (ward home ii)

Conditions: Vital Sign Monitoring; Clinical Deterioration; Hospital At Home

Summary: the study aims to investigate the use of wireless, continuous monitoring in patients at home including the frequency of alarms triggered by abnormal vital parameters and their significance for (re)hospitalisation/serious adverse events(sae) and/or death within 30 days.

acute hospital admissions challenge the capacity of the healthcare system. readmission is common among patients with chronic medical diseases, and many patients admitted for acute conditions are often subsequently observed at the hospital for hours and often with one overnight stay for observation purposes alone. recent medico technical research has allowed continuous and wireless monitoring of patients' vital signs in-hospital, but the practice at home remains uninvestigated. however, the technology has the potential to relieve hospital overcrowding by offering continuous and real time analytics of vital signs in high-risk patients at home.

Eligibility criteria:
inclusion criteria: adult patients (≥18 years) admitted (with at least one night stay) with an acute medical disease and scheduled for discharge to their own homes adult patients (≥18 years) who have contacted the ems and, after assessment by paramedic personnel, not deemed sick enough for immediate hospital admission. exclusion criteria: patients placed on palliative treatment. acceptable chronically abnormal vital parameters of spo2\ 24, or hr\>110. allergy to plaster, plastic, or silicone. a pacemaker or implantable cardioverter defibrillator (icd) device. if the patient was deemed not able to open the front door when visited by the investigator. inability to give informed consent.
kaneka endovascular embolization and protection

Conditions: Aneurysm Cerebral

Summary: prospective, multi-center, non-randomized registry / study, up to 164 patients enrolled and followed at 180 days +/- 45 days and again at 365 days +/- 90 days post procedure

assess and describe real world clinical data on i-ed coils characterize the acute and long-term performance of ied coils when used for treating for an intracranial aneurysm may be used alone or in combination with other adjunctive device(s) study duration anticipated timeline for study: patient enrollment in 18 - 24 months completion of follow-up 12 months after last patient enrolled

Eligibility criteria:
inclusion criteria: * target aneurysm of 4mm - 14mm in size * ruptured or unruptured * suitable for embolization with coils * may be treated with or without assist devices exclusion criteria: * unstable neurological deficit in unruptured cases (condition worsening within last 90 days) * pre-planned staged procedure of target aneurysm * mrs score 3 or more * hunt hess score more than 3 for subjects with ruptured aneurysm * evidence of active infection (e.g.,fever, temperature \>38 degrees c and/or wbc \>15,000)

Keywords: aneurysm coil i-ed coil embolization neuro endovascular
spinal anesthesia induced hypotension during cesarean section

Conditions: Hypotension

Summary: the purpose of this study is to compare two methods for preventing low blood pressure associated with spinal anesthesia during cesarean sections.

many women experience low blood pressure after spinal anesthesia for cesarean section. this low blood pressure may result in nausea, vomiting dizziness and impairment of uterine blood flow.the purpose of this study is to compare two methods for preventing low blood pressure associated with spinal anesthesia during cesarean sections. in both methods, we will attempt to prevent low blood pressure using phenylephrine infusion that has been shown to be effective in recent research. in addition to receiving phenylephrine one group of patients will receive standard salt solution (ringer's lactate solution), while the other group will receive a different, intravenous fluid called hydroxyethylstarch.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status i and ii * elective cesarean section * weight 50-120 kg, height 150-180 cm * normal singleton pregnancy * beyond 36 weeks gestation * no known fetal abnormalities * ages 18-35 exclusion criteria: * contraindications to spinal anesthesia * multiple gestation, placenta previa, accreta * pregnancy induced hypertension or preeclampsia * diabetes mellitus, cardiovascular diseases * coagulopathy * spinal cord abnormalities, spinal surgery, or preexisting neurological dysfunction * baseline hr \<65 * failed spinal anesthesia/inadequate sensory block for surgery * history of abnormal bleeding * history of adverse reactions to hydroxyethylstarch

Keywords: spinal anesthesia cesarean section