Kornimate/medical-research-clean huggingface dataset:
effects of a motor imagery exercise protocol in patients with fibromyalgia

Conditions: Fibromyalgia; Pain, Chronic; Image, Body; Psychological Distress

Summary: the aim of this study was to evaluate the efficacy of a novel approach with a motor imagery-based exercise program versus conventional rehabilitative approach in fibromyalgia syndrome (fm): reduction of pain was set as the primary outcome.

evidence about the therapeutic efficacy of exercise intervention programs in fm is still low and many authors suggested improving standardized exercise prescription for fm to achieve optimal results. in the literature, as an alternative approach, rehabilitative protocols in group music and imagery seem to improve well-being and reduce anxiety in women with fm and suggest that music and imagery may help diminish pain intensity and depression. a rehabilitative approach should also consider the psychological and emotional aspects and, when possible, be accompanied by cognitive-behavioral therapy. the purpose of this research is to evaluate the possible efficacy of a novel approach with a motor imagery-based exercise program versus conventional rehabilitative approach in fm syndrome: the reduction of pain was set as the primary outcome as well as taking into account the patient's psychological and emotional condition. this study was designed as a double-blind, randomized, controlled trial.

Eligibility criteria:
inclusion criteria: * experienced widespread pain for more than 3 months * pain with 4 kg/cm2 pressure at 11 or more of the 18 tender points * aged 18 to 60 years * pharmacological therapeutic regimen must have been stable for at least three months before exclusion criteria: * pregnant women * pacemaker wearers * overlapping painful conditions * presence of autoimmune or hematologic diseases * psychiatric disorders in pharmacological and psychological treatment * other causes of chronic pain * other diseases such as epilepsy, tumors, major neurological problems and diabetes

Keywords: fibromyalgia pain imagery
a study of fg-3019 in subjects with liver fibrosis due to chronic hepatitis b infection

Conditions: Liver Fibrosis Due to Chronic Hepatitis B Infection

Summary: the overall goal of this trial is to evaluate the efficacy of fg-3019 for reversing liver fibrosis in subjects with chronic hepatitis b infection who are beginning antiviral therapy with entecavir. this phase 2 randomized, double-blind, placebo controlled study will enroll subjects with chronic active hepatitis b infection and liver fibrosis (ishak score ≥2) who are eligible for antiviral therapy.


Eligibility criteria:
inclusion criteria * signed informed consent * age of 18 to 75 years, inclusive * hbsag positive for ≥24 weeks prior to screening * liver fibrosis, confirmed by biopsy and histology * willing to use contraception exclusion criteria: * female subjects who are pregnant or nursing * prior antiviral therapy, with the exception of interferon therapy \>6 months prior to day 1 * severe heart failure * present hepatocellular carcinoma and history of other cancers * severe anemia * advanced kidney disease * immunosuppressive therapy within 24 weeks prior to screening * alcohol or drug abuse within the 12 months prior to screening * trauma or surgical procedures requiring hospitalization within 8 weeks prior to day 1 * planned elective surgery during the study including 9 weeks following the final dose of study drug * history of allergy against nucleoside analogs or human, humanized, chimeric, or murine monoclonal antibodies * inability to cooperate with study personnel or a history of noncompliance to the medical regimen (i.e., subjects who would be expected to comply poorly with the treatment) * clinically significant medical or psychiatric condition considered a high risk for participation in an investigational study * morbid obesity (body mass index \[bmi\] \>40) * inadequate iv access

Keywords: connective tissue growth factor (ctgf) human igg1 monoclonal antibody
a study of bone marrow transplantation using fully-matched relatives as donors for patients with hematological malignancies

Conditions: Hematological Malignancies; Leukemia; Lymphoma; Multiple Myeloma; Hodgkin's Disease

Summary: this research study uses a drug called cyclophosphamide to decrease the incidence of gvhd in matched sibling hematopoietic stem cell transplant. in doing so, the goal of the study is to increase overall survival.

this research protocol has been developed for patients undergoing matched-sibling hematopoietic stem cell transplant (hsct). the patients who are treated according to this 2 step allogeneic hsct protocol will receive cyclophosphamide to induce in-vivo tolerization of both autologous and allogeneic lymphocytes, followed by an allogeneic cd34-selected hsct. the primary research questions relate to immune reconstitution, incidence of gvhd, and relapse in patients who receive lymphocyte treatment of this type in allogeneic hsct and how it impacts overall survival.

Eligibility criteria:
inclusion criteria: 1. any patient with a hematologic or oncologic diagnosis in which allogeneic hsct is thought to be beneficial, and in whom front-line therapy has already been applied. patients will be considered high-risk if they have any of the following: 1. age \> 50 years 2. ecog performance status of \<2 3. acute leukemia: requiring more than one chemotherapy regimen to obtain 1st cr; second or greater cr, 1st relapse; any ph+ all 4. cml 2nd chronic phase, accelerated phase, or blastic phase 5. mds with ips of intermediate 2 or greater 6. any myeloproliferative disorder 7. hodgkin lymphoma: relapsed, refractory, or primary induction failure 8. non-hodgkin lymphoma: relapsed, refractory, primary treatment failure, or not eligible for an autologous hsct 9. other conditions not listed will be assessed as high-risk by the pi 2. patients must have a related donor who is either hla-identical or a one antigen mismatch at the hla- a; b; c; and dr loci. 3. patients must adequate organ function: 1. lvef of \>45% 2. dlco (adjusted for hemoglobin) \>45% of predicted 3. adequate liver function as defined by a serum bilirubin \<1.8, ast or alt \< 2.5x upper limit of normal 4. creatinine clearance of \> 60 ml/min 4. patients must be willing to use contraception if they have childbearing potential 5. able to give informed consent exclusion criteria: 1. ecog performance status of 3 or 4. 2. hiv positive 3. active involvement of the central nervous system with malignancy 4. psychiatric disorder that would preclude patients from signing an informed consent 5. pregnancy 6. patients with life expectancy of \< 6 months for reasons other than their underlying hematologic/oncologic disorder.

Keywords: myeloablative hematopoietic stem cell transplant cyclophosphamide tolerization 2 step approach hematological malignancies leukemia lymphoma multiple myeloma hodgkin's disease
safety and feasibility evaluation of robot assisted physiotherapy exercises with rex

Conditions: Spinal Cord Injury

Summary: prospective, open label, single arm, non-randomized, non-comparative registry study of robot-assisted physiotherapy exercises with the rex robot powered exercise system in patients with spinal cord or other injury preventing unsupported patient ambulation.

the objective of this feasibility study is to evaluate the overall device safety when used in spinal cord injury hospitals or rehabilitation centers under the supervision of a physician and/or qualified rehabilitation specialists.

Eligibility criteria:
inclusion criteria * wheelchair user * spinal injury levels of c4 down to l5 * has no outstanding skin integrity issues that could be effected by the rex device * should be between approximately 1.42m and 1.93m in height. more specifically, rex is able to accommodate the following limb lengths: * upper leg length : 380 - 470 mm * lower leg length : 366 - 470 mm * heel position (ankle to hind foot) : 40 - 92 mm * floor to ankle height (to be measured while wearing the shoe to be used for mobilising in rex) : 96 - 116 mm * has a skeletal hip width of 380 mm or less (limit imposed by rex) * is between 40 kg and 100 kg weight (limits imposed by rex) * has the manual dexterity to work a joystick * sufficient passive range of motion in the hip, knee and ankle of at least * hip 90 degrees flexion 15 degrees hip extension 20 degrees abduction 16 degrees adduction * knee 0 degrees extension 93 degrees flexion * ankle 20 degrees dorsiflexion (with weight bearing and 10 degrees knee flexion) 22 degrees dorsiflexion (with 93 degrees knee flexion) 10 degrees plantar flexion 9 degrees inversion 9 degrees eversion * thigh lateral diameter of \< 135 mm (230 mm above the knee joint line) * calf lateral diameter of \< 100 mm (90 mm below the knee joint line) * manual dexterity to work a joystick with or without a t-bar and use emergency stop button * no contraindications to standing or mobilising * patients must choose to participate, and must have signed the informed consent document exclusion criteria: * patients who do not meet inclusion criteria or physician discretion. * patients with history of impaired cardiac function who have been referred to and reviewed by a medical professional. with a decision made that they should not continue in the trial due to their impaired cardiac function. * patients contraindicated to walk or stand * patients with spinal injury outside inclusion criteria * withdrawal or refusal to sign informed consent * any other contraindication based on physician discretion * known allergy (skin contact) to materials used in rex
effects of a positive slope treadmill training in individuals after stroke. (hemislope)

Conditions: Stroke

Summary: the main objective of this study is to determine if a single session of treadmill training with a positive slope improves the kinematic parameters of the hip, knee and ankle on the paretic lower limb. secondarily we will quantify the efficiency of a such training on kinetic and functional parameters.

comparison between patients having a single session of treadmill training with slope and those having a single session of treadmill training with no slope

Eligibility criteria:
inclusion criteria: * hemiplegic patient * capacity to walk during 20 minutes without technical assistance exclusion criteria: * patient with bilateral brain lesions * previous orthopedic surgery * pregnant woman
performance of a photoscreener for vision screening in a haitian pediatric population

Conditions: Amblyopia; Myopia; Hyperopia; Astigmatism; Cataract; Retinoblastoma; Trachoma; Xerophthalmia; Glaucoma; Retinopathy of Prematurity

Summary: screening of haitian children between the ages of 3 and 6 years old for amblyogenic risk factors with the use of the spot photoscreener. the photoscreener results will be compared to the complete ophthalmologic evaluation. primarily, this will allow evaluation of the performance of the spot photoscreener in the haitian children population. secondarily, this study will gather epidemiological information on vision problems in the haitian children population.

screening of haitian children between the ages of 3 and 6 years old for amblyogenic risk factors with the use of the spot photoscreener before and after cycloplegia. the photoscreener results will be compared to the complete ophthalmologic evaluation. the ophthalmologic evaluation includes visual acuity, ocular alignment, slit lamp evaluation, cycloplegic refraction and dilated fundus evaluation. first of all, this will allow evaluation of the performance of the spot photoscreener in the haitian children population. second of all, this study will gather epidemiological information on vision problems in the haitian children population.

Eligibility criteria:
inclusion criteria: * haitian children aged 3-6 years of age * signed consent form from a legal guardian exclusion criteria: * previous vision problem diagnostic * unsigned consent form
study to analyze mutations in v600 braf oncogen in participants with metastatic melanoma

Conditions: Metastatic Cancers

Summary: this is a national, multicenter, cross-sectional epidemiological study in adult spanish participants diagnosed with advanced or metastatic melanoma.


Eligibility criteria:
inclusion criteria: * valid tumor samples from participants diagnosed with stage iiic or iv melanoma * written informed consent granted exclusion criteria: - do not fulfill one or more inclusion criteria

Keywords: v600 braf mutation metastatic melanoma
does teriparatide (rhpth 1-34) promote fracture healing in proximal humeral fractures?

Conditions: Humeral Fracture

Summary: 40 postmenopausal women, with a non-operated proximal humeral fracture, will be randomized to standard treatment (physiotherapy) or standard treatment + forsteo (rhpth 1-34) during 4 weeks. follow-up will be at 7 weeks and 3 months including x-ray and dash score (the disabilities of the arm, shoulder and hand) measuring physical function, and pain on a visual analoge scale (vas). two doctors, blinded to the treatment, will judge the callus formation and healing on the x-rays and guess the treatment. the dash score and the pain score will be compared between the treatment groups. the investigators hypotheses are that callus formation and healing will be more pronounced and that patients have less pain and better function in the rhpth 1-34 group.


Eligibility criteria:
inclusion criteria: * proximal humeral fracture * postmenopausal woman 50 years or older * non-surgical treatment exclusion criteria: * dementia or psychiatric disorder * known malignancy \< 5 years prior to fracture * calcium above reference value * signs of liver disease * creatinine over ref. value * inflammatory joint disease * alcohol or drug abuse * oral corticosteroid medication * long-term nsaid-treatment (=\> 3 months prior to fracture)

Keywords: teriparatide fracture healing proximal humeral fractures
safety and efficacy of the carbofix pedicle screw system

Conditions: Degenerative Disc Disease; Spondylolisthesis; Spinal Stenosis; Spinal Curvatures; Tumor

Summary: the purpose of this study is to evaluate the safety and efficacy of carbofix' pedicle screw system in the lumbar spine.


Eligibility criteria:
inclusion criteria: 1. subject is 18 years old or older. 2. confirmation that the physical examination of radiopathy, myelopathy or combination is in correlation with the affected level. 3. lumbar ct, mri, or myelography confirms the level of involvement is consistent with the subject's examination. 4. informed consent given by the subject. exclusion criteria: 1. subject is not eligible for fixation with market-available fixation means. 2. familial history nf2. 3. acute traumatic spinal injury with or without neurological signs. 4. metabolic bone disease. 5. history of paget's disease or other osteodystrophies whether acquired or congenital, including renal osteodystrophy, hyperthyroidism, hypothyroidism hyperparathyroidism, ehrlers-danlos-syndrome, osteogenesis imperfecta, achondroplasia, tuberculosis. 6. history of mental disorder or current psychiatric treatment. 7. pregnancy and/or female subjects intending to become pregnant within the expected time frame of the study and/or female subjects of child bearing age who do not use conventional contraceptive methods. 8. immune deficiency disease. 9. infection in the location of the operative site, discitis, osteomyelitis, fever and/or leukocytosis (as diagnosed based on the results of cbc and esr tests). 10. scoliosis. 11. treatment with drugs that may interfere with bone metabolism such as: 1. cumulative dose of 150 mg. of prednisone or equivalent within the last 6 months. 2. calcitonin within the past 6 months. 3. bisphosphonates for 30 days or more within the last 12 months. 4. bone therapeutic doses of fluoride for 30 days or more within the last 12 months. 5. bone therapeutic doses of vitamin d or vitamin d metabolites for 30 days or more within the last 6 months. 6. treatment by chemotherapy within the last 12 months. 12. lack of willingness to make a commitment to return for required follow up visits. 13. drug and/or alcohol abuse. 14. morbid obesity. 15. metal allergies. 16. recent use of other investigational drugs or devices (within the past 30 days).
production of gut microbiota-derived metabolites in response to different fatty acid profiles

Conditions: Obesity, Abdominal; Diabete Type 2

Summary: the proposed project mainly aims to investigate the microbial processes leading to dietary metabolites production, independently of long-term microbiota adaptation to the diet, by measuring the microbiota-derived metabolite production from a meal sequence rich in saturated fatty acids (sfa) or the same meals but rich in polyunsaturated fatty acids (pufa) in individuals with or without obesity and type 2 diabetes (t2d)

the gut microbiota interacts with the host's enteric and systemic functions through the production of gut microbiota-derived metabolites. a subset of these metabolites, the endocannabinoids (ecb) and their congeners are derived from fatty acids and play a crucial role in metabolic health. the research project aims to study gut microbiota-derived metabolites, including the ecb and their congeners, in response to a 2-day diet rich in polyunsaturated fatty acids or rich in saturated fatty acids in individuals with or without abdominal obesity and type 2 diabetes. the investigators hope to better understand the kinetic production of circulating endocannabinoidome mediators derived from fatty acids in the diet.

Eligibility criteria:
inclusion criteria: * men and women aged between 45 and 65 years, menopaused women ; * body mass index between 20 to 35 kg/m² ; * general good health ; * score of diet quality (hei) between 40 and 70 ; * computer and internet access ; * basic understanding of written french ; * daily stool frequency. exclusion criteria: * intestinal pathologies including inflammatory bowel disease and gastrointestinal cancers ; * alcohol consumption greater than 15 portions for men and 10 for women weekly. * active tobacco and cannabis usage ; * consumption of omega-3 dietary supplements ; * consumption of dietary supplements (vitamins and probiotics) - must be ceased 2 weeks before the dietary intervention ; * completion of a course of antibiotics in the past 3 months ; * important weight change (+/- 5 kg) in the past 6 months ; * type 1 diabetes or insulin-treated diabetes.

Keywords: gut microbiome endocannabinoidome metabolites microbiome-endocannabinoidome axis obesity type 2 diabetes nutrition fatty acids
utilization of platelet gel for treatment of diabetic foot ulcers

Conditions: Diabetic Foot Ulcers

Summary: diabetes is a multiorgan disease and considered a major health problem in different societies. one of the complications the pain particularly in the extremities resulting from a process known as diabetic foot ulcer. the diabetic patients are subjected to many complications because of foot ulcers, many of them like as chronic wound disease or pressure ulcers (bed sore). routinely used medical measures for diabetic foot ulcers are depended to nursing care and take too long until pain relief. among many tested materials and works for wound healing such as debridement, tissue oxygenation, and skin transplantation, platelet-derived compounds are allocated the pivotal position between investigators to tissue regeneration and shortening the wound healing process. many of platelet components are procured from platelet rich plasma (prp) from whole blood donation. furthermore, it requires to an additional purification step to diminish the volume and facilitate handling in some studies. it means that platelet concentrates (pcs) may be obtained leading to more concentrated platelets in lower volume. two types of granules in platelet is responsible for storage of many useful and different growth factors: dense or delta and alpha granules. platelet-derived growth factors have the ability to growth and differentiation of numerous cells. also, the antibacterial effect of these growth factors has been reported. to better efficacy and comfortable utilization of platelet, it is feasible to form the platelet gel and then apply on wound sites. this study is a double blind randomized controlled trial to evaluate the positive effects of umbilical cord blood-derived platelet gel in 244 patients with diabetic foot ulcers.

in this study all qualified patients (based on the inclusion and exclusion criteria) were randomly allocated into three study groups by a stratified permuted block randomization method: group a received platelet rich plasma gel, group b (placebo) received platelet poor plasma gel, and group c received lubricant gel. all of the patients underwent a standard long protocol for knee osteoarthritis. all patients with diabetic foot ulcer are selected.on average,in each instance, the amount of platelets in the peripheral bloodis4 to6 times the baseline level. group a (interventional): application of 20-30ml of gel from platelet rich plasma (prp) group b (placebo): application of 20-30ml of gel from platelet poor plasma (prp) group c (control): application of 20-30 ml of lubricant gel (used typically for sonography)

Eligibility criteria:
inclusion criteria: * history of at least 4 weeks hospitalization * uncontrolled diabetes * ejection fraction \> 30% exclusion criteria: * mechanical origin for wound * history of infectious, systemic diseases, immune deficiency and coagulation disorders

Keywords: platelet gel diabetic foot ulcer umbilical cord blood
an observation study on the identification of prescription patterns of lodient tab(telmisartan/s-amlodipine)

Conditions: Hypertension

Summary: this study identify prescription patterns of lodient tab and evaluate the changes of the hypertension symptoms (bp pressure) who are first prescribed and taking lodient tab.

this study aims to observe changes in symptoms according to the treatment effect of hypertension for 6 months after lodient tab prescription.

Eligibility criteria:
inclusion criteria: 1. adults over 19 years of age 2. a person diagnosed with hypertension 3. a person who has been first prescribed lodient tab within the past 4 months as of the irb approval date or is scheduled to be prescribed lodient tab 4. a person who voluntarily agreed in writing to this study exclusion criteria: 1. pregnant women or nursing mothers 2. persons subject to prohibition according to the permission of the lodient tab 3. patients who in the judgement of the investigator, were inappropriate to participate in the study