Kornimate/medical-research-clean huggingface dataset:
a mobile health intervention to achieve appropriate gestational weight gain in overweight/obese women

Conditions: Gestational Weight Gain

Summary: the aim of this trial is to investigate the effectiveness of a mobile health (mhealth) intervention to help overweight and obese women achieve appropriate gestational weight gain (gwg) for their pre-pregnancy body mass index (bmi). the goal of the intervention is to help women achieve gwg within the range recommended by the institute of medicine. the investigators propose an adaptive intervention that begins with an effective, yet low resource-intensive treatment and then provides incremental support and resources only to patients who need them. the intervention includes: 1) an mhealth tool allowing data to be automatically transmitted to a mobile website; 2) personalized text messages; and 3) personalized 1:1 telephone coaching sessions. the latter more intensive components are reserved for patients whose gwg is not within the iom guidelines. the lifestyle intervention will be delivered through 1 telephone counseling session with a study dietician trained in motivational interviewing techniques, as well as through technology-based tools, automated text messages and weekly e-mails of core lifestyle intervention sessions. personalized text messages and 1:1 telephone coaching sessions will be given to those who are not meeting the gwg guidelines. the lifestyle intervention will be compared to usual medical care. maternal outcomes will be assessed shortly before delivery and at 6 weeks postpartum. infant birthweight and weight at one year will also be assessed.


Eligibility criteria:
inclusion criteria: * pregnant * women receiving prenatal care at kaiser permanente san francisco and oakland and whose obstetric care clinicians consent to participate; * pregravid bmi 25 to \<40 (as determined from a measured pregravid weight in electronic medical record); * has access to a smartphone and wi-fi; * provides informed consent to participate. exclusion criteria: * multiple births; * planning to move out of the area during the study period; * inability to speak, read, or understand english; * placed on bed rest at time of enrollment; -\>15 weeks' gestation at enrollment.

Keywords: gestational weight gain lifestyle intervention body weight overweight obesity signs and symptoms body weight changes
withdraw drug in stable igg4-related disease

Conditions: Autoimmune Diseases

Summary: evaluation and prediction of relapse risk after glucocorticoid or immunosuppressant withdrawal in patients with stable igg4 related disease: a prospective cohort study from china.

igg4-related disease (igg4-rd) is a chronic autoimmune disease with a relapsing-remitting course. for patients in remission, glucocorticoid (gc) and immunosuppressant are used to be maintained for a long time in fear of disease flare. long-term gc and immunosuppressant could bring a lot of side-effects and economic burden. whether and when patients with stable disease should withdraw gc or immunosuppressant? how about the relapse risk respectively? what are the risk factors for disease flare? all the above remain unclear. the aim of this study is to explore the relapse risk after gc or immunosuppressant withdrawal in igg4-rd patients with stable disease and to establish a predictive model for risk stratification. meanwhile the investigators aim to testify the effects of immunosuppressant in preventing igg4-rd relapse. this study is a prospective cohort clinical trial.

Eligibility criteria:
inclusion criteria: 1. all patients must meet the following diagnostic criteria of igg4rd (2011): 1)swelling, sclerosing and inflammatory involvement of one or more organ, including sclerosing pancreatitis, sialadenitis (mikulicz disease), sclerosing cholangitis, inflammatory pseudotumors, retroperitoneal or mediastinal fibrosis, interstitial nephritis, hypophysitis, sclerosing dacryoadenitis, inflammatory aortic aneurysm, lymphadenopathy, or other inflammatory conditions; 2)elevated serum igg4 (\>1.35 g/l); 3)histopathologic features of fibrosis and/or lymphocytic and polyclonal plasma cell infiltration (and igg4+ plasma cells on immunohistology when performed). patients fulfill 1)+2)+3) are diagnosed as definite igd4rd, 1)+2): possible igg4rd; 1)+3): probable igg4rd. exclusion of other diseases. 2. disease stabilized more than one year (responder index \< 2 points) 3. dose of glucocorticoid(gc): prednisone (or equivalent) ≤ 7.5mg/d for more than 6 months 4. immunosuppressant: one of the following drugs, the same dose maintain at least 3 months (mycophenolate mate \<= 1g/d or leflunomide \<=20mg/d or methotrexate \<=12.5mg/w or azathioprine \<=100mg/d). exclusion criteria: 1. patient was diagnosed other connective tissue diseases 2. patient with tumor 3. women during pregnancy or planning pregnancy 4. patient with active infections, including hiv, hcv, hbv, tb, etc. 5. patient with severe irreversible organ damage 6. active igg4-rd, responder index \>= 2 points 7. stable condition less than one year. 8. patient with two or more immunosuppressive agents. 9. biological agents (such as cd20 monoclonal antibody and tnf-a inhibitor) have been used for half a year before admission. 10. patient with igg4-rd recurrence during hormone reduction in the past.

Keywords: immunoglobulin g4-related disease
couple-oriented prenatal hiv counseling in low and medium hiv prevalence countries

Conditions: Partner HIV Testing; Couple HIV Counseling; Couple Communication; HIV Incidence

Summary: anrs 12127 prenahtest is an intervention trial conducted in four countries (cameroon, dominican republic, georgia and india), where pregnant women are randomized during prenatal care to receive either standard post-test hiv counseling, or an innovative intervention called couple-oriented post-test hiv counseling (coc). the aim of the coc intervention is to empower women to communicate with her male partner about hiv, and hiv testing in particular, and encourage him to return for hiv testing and/or couple hiv counseling (where both couple members are counseled together). prenahtest is the first randomised trial testing a prenatal intervention to increase partner hiv testing.


Eligibility criteria:
inclusion criteria: * attending her first anc visit for the current pregnancy in the study centre * accepting to participate in the study and being able to give informed consent ii * currently having a partner (the man who the woman considers as her regular partner on the day of inclusion, even if this person is not the baby's father) iii * accepting follow-up (including home visits if necessary) by the project staff until 15 months after delivery exclusion criteria: * having been tested for hiv during her current pregnancy * having a male partner who was tested for hiv during her gestational period v * having a partner who works out of the predefined study area or is absent for more then 6 months * being unwilling/unable to provide address/contact information * having an intoxication and/or mental impairment at the moment of recruitment

Keywords: partner hiv testing couple hiv counseling couple communication on sexual and reproductive health hiv incidence incidence of pregnancies disclosure condom use
chinese versions of the swanson, nolan, and pelham, version iv (snap-iv) scale and strengths difficulties questionnaire.

Conditions: Attention-deficit/Hyperactivity Disorder

Summary: background: attention-deficit/hyperactivity disorder (adhd) is a common childhood-onset neuropsychiatric disorder (7.5% in taiwan) with great impact on individual, family, and society. the diagnosis of adhd is mainly based on clinical interview of parents and children with assistance of teachers' reports. self-administered rating scales are useful for screening, assistance of diagnosis, and measurement of symptom changes over time or due to treatment effect. the goals of this study are to establish the norms and psychometric properties of the chinese version of teacher and parent forms of the swanson, nolan, and pelham, version iv (snap-iv) and the teacher, parent, and student forms of the strengths and difficulties questionnaire (sdq) for future studies on adhd in taiwanese populations. subjects and methods: this is a cross-sectional, school-based survey with a multi-stage sampling method. the participants include a school-based sample of 3534 first to eighth graders was recruited from four areas: taipei city, taoyuan county, tainan city and chiayi county. among them, 200students will be reassessed at 2-week interval for the test-retest reliability study. the instruments comprise the chinese version of child behavioral checklist (cbcl), sdq, snap-iv, and adult adhd rating scale. the informants include student participants older than 10 years old, their parents, and teachers. the main statistical methods include pearson correlation, intraclass correlation, chronbach's α for internal consistency, and mixed model to address lack of independence within the same classes and schools. anticipated goals: we expect that this study will reach the following objectives: 1. to obtain the primitive information about the prevalence of adhd symptoms and emotional/behavioral problems among children and adolescents in taipei and yun-ling; 2. to enhance the awareness of school teachers and counselors about adhd and other behavioral/emotional problems among students; 3. to establish psychometric properties of the chinese versions of snap-iv and sdq for future use in clinical, school, and research settings.

this protocol was prepared in chinese

Eligibility criteria:
inclusion criteria: * school-based subjects: around 3600 grade 1 to grade 8 students aged 6-16 from four sites in taiwan and their parents (n = 7200) * clinical subjects with adhd: children and adolescents ages 6-16, who are diagnosed with adhd, iq \>70, parents and teachers consent to completion of questionnaires. exclusion criteria: * clinical subjects with adhd: those who are comorbid with pervasive developmental disorder and/or mental retardation or other severe psychiatric disorders. oppositional defiant disorder and conduct disorder are not excluded.

Keywords: adhd, snap-iv, sdq, asrs, reliability, validity
respiratory exercises versus manual therapy and respiratory exercises in moderate smokers

Conditions: Manual Therapies; Respiratory Muscle Training; Exercise Therapy; Inspiratory Capacity

Summary: the aim of this study is to assess if an intervention of manual therapy and motor control exercises combined with an inspiratory muscle training program is more effective than an inspiratory muscle training program alone in increasing the maximum inspiratory pressure in moderate smokers. in addition, the study pretends to evaluate the changes caused by the intervention regarding possible postural changes and thoracic diameter.


Eligibility criteria:
inclusion criteria: * healthy subjects aged between 18 and 60 years and a current smoking rate ≥ 5 points. exclusion criteria: * were excluded participants who presented diagnosis of cardiorespiratory disease, systemic or metabolic disease such as rheumatoid arthritis or cancer, history of thoracic surgery, vertebral fracture, spinal structured musculoskeletal disorders and thoracic region and contraindication to the treatment techniques used (osteoporosis).

Keywords: smokers maximum inspiratory pressure
efficacy and safety study of desmoteplase to treat acute ischemic stroke (dias-4)

Conditions: Stroke

Summary: the purpose of the study is to determine whether desmoteplase is effective and safe in the treatment of patients with acute ischaemic stroke when given within 3 to 9 hours from onset of stroke symptoms.

acute stroke is a major cause of mortality and long-term disability in the developed world. the only currently approved thrombolytic intervention for acute ischemic stroke, which constitutes the majority of strokes, is alteplase (recombinant tissue plasminogen activator; rtpa). the use of alteplase is limited as it is approved for use within 3 hours after symptom onset and by the risk of inducing intracerebral haemorrhage; consequently fewer than 3% of acute stroke subjects are treated. the thrombolytic agent desmoteplase (recombinant desmodus salivary plasminogen activator alpha-1; rdspaalpha-1) produced by recombinant biotechnology has its naturally occurring counterpart in the saliva of the vampire bat desmodus rotundus. compared to alteplase, desmoteplase has a more favourable profile in terms of high fibrin specificity and non neurotoxicity. the study aims to confirm efficacy and safety of desmoteplase for thrombolytic therapy of patients with acute ischaemic stroke in the extended time window of 3 to 9 hours after onset of stroke symptoms.

Eligibility criteria:
inclusion criteria: * diagnosis of acute ischemic stroke * informed consent * age between 18 and 85 years * treatment can be initiated within 3 to 9 hours after the onset of stroke symptoms * nihss score of 4 to 24 * vessel occlusion or high-grade stenosis on mri or cta in proximal cerebral arteries exclusion criteria: * pre-stroke mrs \>1 * previous exposure to desmoteplase * extensive early infarction on mri or ct in any affected area * imaging evidence of ich or sah; av malformation; cerebral aneurysm; or cerebral neoplasm * internal carotid artery occlusion on the side of the stroke lesion * treatment with heparin in the past 48 hours and a prolonged partial thromboplastin time * treatment with oral anticoagulants and a prolonged prothrombin time * treatment with glycoprotein iib - iiia inhibitors within the past 72 hours. use of single agent oral platelet inhibitors is permitted * treatment with a thrombolytic agent within the past 72 hours

Keywords: acute ischemic stroke angiography desmoteplase thrombolytic
healthy beginning initiative

Conditions: HIV

Summary: the purpose of this study is to determine if providing free laboratory test to pregnant women and their spouses at churches, in addition to laboratories or hospitals, will increase the number of pregnant women and their spouses who get screened for hiv, malaria, sickle cell trait, hemoglobin levels, syphilis, and hepatitis b. these tests are necessary to keep mothers healthy during pregnancy and lead to healthy babies. this research is taking place in 40 churches in nigeria.

we are conducting a randomized trial to evaluate the comparative effectiveness of a congregation-based healthy beginning initiative (hbi) delivered by lay health advisors (intervention group; ig), versus a facility based approach (control group; cg) on the hiv testing rate and pmtct completion among 2,700 pregnant women. four dioceses with forty churches nested in the dioceses, will be randomly assigned to either the ig (n=2; n=20) or the cg (n=2; n=20). the hbi combines a family educational game show and an integrated on-site laboratory testing in the context of a baby shower. monthly prayer sessions for pregnant women will be used for recruitment and a baby reception following infant baptisms will be used for follow up after delivery. the primary outcome is difference in testing rate among pregnant women in ig compared to cg. the secondary outcomes are hiv testing rate among male partners and pmtct completion among hiv-infected pregnant women. pregnant women will complete an investigator-administered questionnaire at the baby reception to collect information on hiv testing and pmtct completion. data will be confirmed with health facilities and on-site testing data. this proposal is a collaboration among partners for prevention, education, training, treatment and research (petr-global solutions)/aidsrelief (our pepfar-funded partner in nigeria responsible for training, hiv testing, linkage to treatment and local oversight of the project); new york university school of medicine (program evaluation and shares oversight with pi), board of regents, nshe, obo university of nevada, reno (provide overall oversight, data management and evaluation of program effectiveness).

Eligibility criteria:
inclusion criteria: * pregnant females 18 years and older; * male partners of pregnant females 18 years and older; * subjects must attend church at one of the participating diocese exclusion criteria: - subjects will be excluded if they are not pregnant women or their male partners or are younger than 18 years old.

Keywords: hiv
prevalence of dental caries in preterm birth children aged 2-5 years in primary dentition

Conditions: PreTerm Birth

Summary: the purpose of the study is to determine the prevalence of dental caries in preterm birth children aged 2-5 years in primary dentition.

the purpose of the study is to determine the prevalence of dental caries in preterm birth children aged 2-5 years in primary dentition. pico format:- population (p) = preterm children aged 2-5 years attending cairo university children's hospital "abo el-rish" at el-monira, cairo, egypt. outcome (o) =prevalence of dental caries

Eligibility criteria:
inclusion criteria: * children aged 2-5 years old. * presence of primary teeth only. * children born preterm at gestational age of 6,7 and 8 month. exclusion criteria: * children with disability or mental disorders. * children with immune compromising conditions. * hospitalized and chronically ill children.

Keywords: pre-term children
internet transdiagnostic-cbt for anxiety and depression in adolescents

Conditions: Anxiety Disorder; Depressive Disorder; Emotional Disorder

Summary: this study represents the first research program to assess the efficacy of transdiagnostic cognitive behavior therapy (t-cbt) delivered via internet for anxiety and depression in adolescents. the primary aim of the study was to implement the program amte (aprende a manejar tus emociones \[learn to manage your emotions\]), an internet delivered t-cbt protocol designed to target both anxiety and depression symptoms and disorders (major depression disorder, dysthymic disorder, panic disorder, agoraphobia, generalized anxiety disorder, and social anxiety disorder) in adolescents, and to establish its preliminary efficacy on anxiety and depressive symptomatology. a secondary objective is to demonstrate its potential effect regarding: (a) transdiagnostic measures associated with etiology of emotional disorders including negative affect, anxiety sensitivity, and emotional avoidance, and (b) positive factors including satisfaction with life and positive affect. it is expected that the t-cbt condition will be more effective than the waitlist (wl) control group on the primary (anxiety and depression) and secondary (transdiagnostic and positive factors) outcome measures.


Eligibility criteria:
inclusion criteria: * having identified spanish as the first official language spoken and having good reading comprehension in spanish. * reliable internet access. * meeting the dsm-iv diagnosis criteria for more than one emotional disorder (separation anxiety disorder, panic disorder, agoraphobia, social anxiety disorder, generalized anxiety disorder, specific phobia, major depression disorder, and dysthymia). * no current participating in cognitive-behavioral therapy. * no changes in medication for 4 weeks prior to the study; no changes in medication for the next 3 months. exclusion criteria: * presence of psychotic symptoms or severe depression. * being diagnosed an alcohol and/or substance dependence disorder. * the presence of high suicidal risk. * a medical condition which prevents the participant from carry out the psychological treatment.

Keywords: transdiagnostic-cbt, anxiety, depression, internet-delivered
implementation supports to reduce burnout in therapists delivering child trauma ebps

Conditions: Mental Health Issue

Summary: the majority of children exposed to early adversity and trauma do not have access to sustainably delivered evidence-based mental health programs (ebps), despite the growing prevalence of large-scale multiple-ebp implementation efforts aimed at increasing access to these services. the objective of this proposal is to develop and test a package of implementation strategies designed to promote the sustained delivery of child trauma ebps by reducing provider turnover through targeting the associated mechanisms of provider burnout and organizational psychological safety climate. findings will have a significant public health impact by informing efforts to increase the sustained availability of child trauma ebps, thereby improving outcomes for children exposed to trauma.

many evidence-based mental health interventions have been developed to address the negative outcomes associated with child exposure to early adversity and trauma. despite these promising advances, however, the majority of children served in publicly funded mental health systems do not receive evidence-based programs (ebps). to address this research-to-practice gap, several large-scale, system-driven implementation efforts of multiple trauma ebps have been launched over the last decade, including in the states of california and arkansas. though these system-driven initiatives often increase ebp delivery in community settings following the initial implementation push, long-term sustainment of ebp delivery is low. workforce risk factors, such as provider burnout leading to turnover, have been identified as contributing to the poor long-term sustainment of trauma ebps. therefore, an important step to consider in supporting the longterm sustainment of child trauma ebps is to develop implementation strategies that target provider burnout and organizational climate factors associated with decreased provider retention. this study will develop and pilot a package of implementation strategies, "supporting providers \& preventing the overwhelming of resources in trauma systems" (supports), aimed increasing the sustained delivery of trauma ebps by addressing the factors associated with provider retention related to burnout. the development of supports will be informed by a needs assessment conducted with programs involved with the multiple-ebp implementation efforts in california and arkansas. a small randomized controlled pilot will then be conducted in california.

Eligibility criteria:
inclusion criteria: * therapists who have delivered trauma focused cognitive behavioral therapy (tf-cbt) in the past 6 months. * children aged 3-18 years old who is receiving tf-cbt from therapist enrolled in study. exclusion criteria: * therapists employed at their current agency for less than 6 months. * children less than 3 years old or older than 18 years old.

Keywords: mental health
guided self-help for functional neurological symptoms

Conditions: Functional Neurologic Disease

Summary: functional (psychogenic or somatoform) symptoms are commonly observed in neurology clinics. there is no known empirically validated treatment approach to functional symptoms. cognitive behavioral therapy (cbt) can be effective, but there are major obstacles to its provision. the investigators will test the hypothesis that adding a cbt-based guided self-help (gsh) as compared to treatment as usual (tau) improves patient outcomes.


Eligibility criteria:
inclusion criteria: * adult neurology outpatient with functional symptoms not largely explained by neurologic disease. exclusion criteria: * unable to use the guided self-help intervention, such as due to significant cognitive impairment or unable to comprehend english. * requires specialist psychiatric care. * has headache as the only symptom.