Kornimate/medical-research-clean huggingface dataset:
respiratory restriction in prader-willi syndrome

Conditions: Prader-Willi Syndrome

Summary: the main aim of this study is therefore to evaluate the impact of prader willi syndrome (pws) on lung and thoracoabdominal volumes, respiratory muscle strength and awake ventilatory pattern, and to quantify and localize the pws-induced respiratory restriction.

the aim is to study lung function in obese pws patients using both volitional (spirometry, nitrogen wash-out, and maximal pressure measurements (mip and mep)) and non-volitional (awake ventilatory pattern by opto-electron plethysmography) tests, both in sitting and supine positions. spirometry, nitrogen wash-out, and mip and mep measurements are comprehensive assessments, while optoelectronic plethysmography allows restriction location through accurate measurement of thoracoabdominal volumes. the results of the study could provide useful information about the calculation of the volumes enclosed by the grid of markers (in particular, the volume of the rib cage, which reflects the action of the intercostal muscles, the volume of the abdomen, which reflects the action of the diaphragm in the inspiratory phase and of the abdominal muscles during exhalation and their sum, which represents the total variation of the thoraco-abdominal wall. all these finds could be useful for respiratory rehabilitation protocols for obese pws patients.

Eligibility criteria:
patients with prader willi syndrome inclusion criteria: * age 20-50 years * prader willi syndrome * body mass index \> 30 kg/m2 exclusion criteria: * lack of signed consent form control subjects inclusion criteria: * age 20-50 years * body mass index \< 25 kg/m2 exclusion criteria: * lack of signed consent form

Keywords: thoraco-abdominal volumes lung volumes optoelectronic plethysmography respiratory manoeuvres posture
effect of acupressure applied before cag on pain, anxiety and vital signs

Conditions: Acupressure; Coronary Angiography and Intervention

Summary: this randomized controlled experimental study aimed to determine the effects of acupressure applied before the procedure on pain, anxiety and vital signs in patients who applied to kocaeli city hospital angiography unit and were to undergo planned radial artery coronary angiography.

this randomized controlled experimental study was conducted at the kocaeli city hospital angiography unit to determine the effects of acupressure applied before coronary angiography on pain, anxiety and vital signs of the patients scheduled to undergo coronary angiography. it was conducted at the kocaeli city hospital angiography unit. the study used a stratified block randomization method and 93 patients who met the inclusion criteria were assigned to two different intervention groups, one of which received acupressure and the other a sham intervention before coronary angiography, and a control group receiving standard care. data were collected using the 'personal information form', 'state anxiety inventory (stai)', 'visual analog scale (vas)' and 'patient follow-up form'.

Eligibility criteria:
inclusion criteria for the study * over 18 years of age, * able to understand and speak turkish, * open to communication, * first time undergoing radial artery coronary angiography, * elective patients undergoing planned (non-urgent) coronary angiography, * patients who did not undergo stent/balloon intervention during angiography, * awake and conscious during coronary intervention (not having taken sedatives (dormicum/fentanyl)) * no deformities or lesions in the areas where acupressure will be applied (hematoma, ecchymosis, etc.) * having not taken sedatives or painkillers 5 hours before the angiography, * no experience with acupressure, * no history of attending training courses and yoga classes to control stress and anxiety in the last six months * no diagnosis of anxiety disorder and not receiving medical treatment * no diagnosis of depression and not receiving medical treatment * flat on the back (patients without respiratory distress, etc.), * hemodynamically stable (no chest pain or arrhythmia), * patients who volunteer to participate in the study, exclusion criteria for the study * diagnosed with any psychiatric disease * previously undergone coronary angiography from the radial or femoral artery * chronic pain * used opioid medication * cag procedure to be performed from the femoral artery

Keywords: pain coronary angiography anxiety vital signs acupressure nursing care
trial to compare the efficacy and safety of nnc0195-0092 (somapacitan) with placebo and norditropin® flexpro® (somatropin) in adults with growth hormone deficiency.

Conditions: Growth Hormone Disorder; Adult Growth Hormone Deficiency

Summary: this study is conducted globally. the purpose is to demonstrate the efficacy of once weekly dosing of nnc0195-0092 (somapacitan) compared to placebo and once-daily dosing of somatropin (human growth hormone, hgh) after 35 weeks of treatment in adults with growth hormone deficiency.


Eligibility criteria:
inclusion criteria: * male or female of at least 23 years of age and not more than 79 years of age at the time of signing informed consent * human growth hormone (hgh) treatment naïve or no exposure to hgh or growth hormone (gh) secretagogues for at least 180 days prior to randomisation with any registered or investigational hgh or gh secretagogue product (if only used in connection with stimulation tests for diagnosis of growth hormone deficiency (ghd), subjects can be included) * if applicable, hormone replacement therapies for any other hormone deficiencies, adequate and stable for at least 90 days prior to randomisation as judged by the investigator * for all countries except japan: confirmed diagnosis of adult growth hormone deficiency (subjects must satisfy one of the following criterion and documentation of test results must be available before randomisation (either from subjects' file or new test): 1. insulin tolerance test (itt) or glucagon test: a peak gh response of less than 3 ng/ml (3 mcg/l) 2. growth hormone releasing hormone (ghrh) + arginine test according to body mass index (bmi): i) bmi less than 25 kg/m\^2, a peak gh less than 11 ng/ml (11 mcg/l), ii) bmi 25-30 kg/m\^2, a peak gh less than 8 ng/ml (8 mcg/l), iii) bmi greater than 30 kg/m\^2, a peak gh less than 4 ng/ml (4 mcg/l) 3. three or more pituitary hormone deficiencies and insulin like growth factor - i standard deviation score (igf-i sds) less than -2.0 - for japan only: confirmed diagnosis of adult growth hormone deficiency (subjects with adult onset adult growth hormone deficiency (aghd) need to satisfy at least one of the following criteria, subjects with a history of childhood ghd need to satisfy at least 2 of the following criteria): a. itt test: a peak gh of less than or equal to 1.8 ng/ml (assay using recombinant gh standard) b. glucagon test: a peak gh of less than or equal to 1.8 ng/ml (assay using recombinant gh standard) c. growth hormone releasing peptide 2 (ghrp-2) tolerance test: a peak gh of less than or equal to 9 ng/ml (assay using recombinant gh standard) exclusion criteria: * active malignant disease or history of malignancy. exceptions to this exclusion criterion: - resection in situ carcinoma of the cervix uteri. complete eradication of squamous cell or basal cell carcinoma of the skin * subjects with ghd attributed to treatment of intracranial malignant tumours or leukaemia, provided that a recurrence-free survival period of at least 5 years is documented in the subject's file
prevention of anastomotic leak in gastrointestinal (gi) anastomosis with the application of tisseal in the anastomotic line

Conditions: Anastomotic Leak

Summary: the anastomotic leak is one of the most feared complications in abdominal surgery. certain control methods have been described but the incidence of that complication remains high and is the first cause of mortality in operations where gut anastomosis are performed. with the aim to prove that the use of fibrin glue in the gut anastomosis can improve gut cicatrization, the investigators started the recruitment of patients to that clinical trial in 2007 with the study hypothesis that patients with a gut anastomosis where fibrin glue was used, had less anastomotic leaks than that where the fibrin glue was not used. the investigators have calculated the number of patients necessaries to have statistical significant differences in 200 patients with a rate anastomotic leak expected to be higher than 10%. the study include all the patients that usually arrive to our surgery department and that are expected to have a high risk gut anastomosis: rectal anastomosis, gi anastomosis in the obese patient, small bowel anastomosis in the obstructed one and esophageal anastomosis. the study is randomized, simple blind where the patient does not know if they are in the fibrin glue group or not, and prospectively analyzed. all the clinical and laboratory or radiographic finds relative to the occurrence of an anastomotic leak are recorded.


Eligibility criteria:
inclusion criteria: * patients undergoing gi surgery where a high risk anastomosis is preview to be done exclusion criteria: * haemodynamic instability * advanced oncologic disease * proteins below 4 gr/ml

Keywords: fibrin glue anastomotic leak gastrointestinal high risk anastomosis
reliability and validity of the finnish visual analogue scale foot and ankle and the lower extremity functional scale

Conditions: Foot Diseases; Ankle Disease

Summary: there are no validated patient-reported outcome measures to assess lower extremity function in finnish language. the present study aimed to 1)translate and culturally validate the finnish versions of the visual analogue scale foot and ankle and the lower extremity functional scale, and 2) study the psychometric properties of these two questionnaires

this study assesses the reliability and validity of the finnish versions of the visual analogue scale foot and ankle and the lower extremity functional scale. the english versions were translated and trans-culturally adapted into finnish language according to well accepted international translation guidelines. the psychometric properties are assessed by internal validity, intraclass correlation coefficient and test-retest reliability.

Eligibility criteria:
inclusion criteria: * pathology of the foot and ankle and * surgery due to foot and ankle problems exclusion criteria: * other than foot and ankle surgery * age under 18 years

Keywords: validation studies, patient-reported outcome measures
use of arimidex and zoladex as pretreatment to ivf in women with ovarian endometriosis

Conditions: Endometriosis

Summary: does a combination of arimidex and zoladex make endometriomas shrink and how is the following ivf outcome


Eligibility criteria:
inclusion criteria: * endometrioma(s)with a size of 20-70 mm, persisted for at least 3 cycles * couples with indication and wish for ivf/icsi * age of women: 20-40 years * regular menstrual cycle within normal range (21-35 days) * body mass index (bmi): 18-30 kg/m2 exclusion criteria: * history with osteoporosis, liver-, kidney- or heart disease or thromboembolic disease * treatment of endometriosis with gnrh agonist during the last 3 month
a randomised controlled trial to evaluate the impact of complement theory's live 1:1 exercise coaching and personalised digital application on cancer survivors' cost of care

Conditions: Breast Cancer; Lung Cancer; Prostate Cancer; Colorectal Cancer; Other Cancer

Summary: a decentralized, double-blinded, randomized, 18 month, parallel-group, superiority study to evaluate the impact of complement theory's live 1:1 exercise coaching and personalized digital application on cancer survivors' cost of care

the randomized controlled trial (rct) aims to evaluate the efficacy of complement theory's (ct) personalized and interactive, evidence-backed lifestyle program in reducing healthcare costs and improving health outcomes for survivors across all major cancer types. distinct from conventional interventions, ct's program offers live 1:1 coaching through a mobile app, concentrating on exercise and meditation, and is enriched with evidence-based advice on diet, sleep, and comprehensive lifestyle modifications. this trial is pivotal in assessing the program's effectiveness against an active comparator- expert-recommended lifestyle modification resources suitable for cancer survivors--to isolate the impact of coaching and personalization. the primary objective is to investigate whether ct's novel approach can more effectively reduce healthcare utilization, through reduction of hospitalizations, urgent care visits, and outpatient visits. furthermore, the trial seeks to measure adherence to treatment, and significant health outcomes, including improvements in quality of life scores (qols) to provide a holistic evaluation of the program's impact on patient care and well-being. as an exploratory effort, the trial will also measure cancer progression, recurrence in prostate and colorectal cancer survivors alone.

Eligibility criteria:
inclusion criteria: * cancer type: breast, prostate, colorectal, lung and other cancer * cancer stage: stage 1 to 4 * treatment status: has undergone any cancer-related treatment in last 12 months * age: 21 to 64 * permission to access to last 1 year digital health records * access to smartphone or a tablet exclusion criteria: * excludes individuals who have undergone surgery within the last 4 weeks or will undergo surgery in the next 4 weeks * participants declared medically unfit by their physicians to do physical exercise * ecog score 3,4 or 5

Keywords: other cancer here refers to all cancers apart from breast, lung, prostate and colorectal cancer
the effect of virtual reality goggles and stress ball used during intravenous catheterization on pain and fear in children

Conditions: Pain, Procedural; Anxiety; Pain Management

Summary: although distraction methods such as virtual reality glasses, watching videos, watching cartoons, etc. have been reported to reduce pain in the literature, studies on which method is more effective in reducing pain are limited. considering the developmental period characteristics, virtual reality glasses and stress ball squeezing may be effective in the 6-12 age group during painful intervention. however, no study has been found in the literature on which technique is more effective (9-23). therefore, investigating the effects of virtual reality goggles and stress ball squeezing on pain and fear in children aged 6-12 years as a distraction method during intravenous catheterization may enable nurses to determine the technique with high clinical usefulness in pain management.

provide a brief summary of the study, including the purpose, objectives, and brief methodology.

Eligibility criteria:
inclusion criteria: * children aged 6-12 years, * between april 20, 2024 and october 20, 2024, children admitted to mersin toros state hospital pediatrics departments, * children scheduled for intravenous catheterization, * those who signed the informed consent form (child and parent), * children without mental and developmental retardation, * they are children who can speak and communicate in turkish. exclusion criteria: * children under 6 years old and over 12 years old, * children hospitalized between april 20, 2024 - october 20, 2024 in clinics other than mersin toros state hospital pediatrics service, * children for whom intravenous catheterization is not planned, * those who did not sign the informed consent form (child and parent), * children with mental and developmental retardation, * they are children who cannot speak turkish and cannot communicate.

Keywords: distraction fear pain
correlation between handgrip strength and air trapping in patients with stable chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the goal of this observational study is to investigate the relationship between handgrip strength and air trapping in patients with chronic obstructive pulmonary disease (copd). the main question it aims to answer is: • is handgrip strength correlated with air trapping in copd patients? participants will perform handgrip strength test and lung volume measurement.

this is a cross-sectional study in copd patients. copd patients aged 40 years or older were included. handgrip strength test and lung volume measurement will be tested in each patient. handgrip strength will be measured using a hand dynamometer. lung volume will be assessed using a body plethysmograph.

Eligibility criteria:
inclusion criteria: * age 40 years or older * postbronchodilator fev1/fvc \<0.7 * \>10 pack-year smoking history exclusion criteria: * copd exacerbation within 3 months * inability to perform handgrip strength test or lung volume measurement

Keywords: chronic obstructive pulmonary disease handgrip strength air trapping lung volume correlation
vaginal estrogen and pelvic floor physical therapy in women with symptomatic mild prolapse

Conditions: Pelvic Organ Prolapse

Summary: this is a randomized controlled trial in which women with symptomatic mild pelvic organ prolapse undergoing pelvic floor physical therapy (pfpt) receive vaginal estrogen versus placebo to see if a combined approach to treatment leads to improvement in clinical outcomes. the investigators predict that pfpt in combination with vaginal estrogen will lead to decreased pelvic floor symptoms and improved anatomical support corroborated by biomarker data.

the pathogenesis of pelvic organ prolapse (pop) is unknown. few studies have correlated patient symptoms and amount of prolapse with biomarkers. pop has traditionally been managed with a pessary or surgery. recent studies suggest a reduction in pop symptoms following pelvic floor physical therapy (pfpt). vaginally delivered hormones are also commonly used to treat prolapse symptoms, with little evidence supporting a clinical benefit. the investigators hypothesize that the optimal approach to improving prolapse symptoms in the patient with mild prolapse requires re-alignment and strengthening of levator muscles via pfpt, and optimization of tissue integrity via local estrogen therapy. the investigators propose to test this hypothesis in a randomized controlled trial in which women with symptomatic mild prolapse opting for pfpt, receive treatment with pfpt in combination with vaginal estrogen versus placebo. the investigators predict that the combined approach will lead to decreased symptoms and improved anatomical support corroborated by biomarker data.

Eligibility criteria:
inclusion criteria: * women in good health aged 40-80 * has symptoms of pelvic organ prolapse; answers yes to at least 1 of the following questions: do you feel or see a vaginal bulge? do you feel pressure in the vagina? * meets pop-q criteria on exam for stage i, ii, or iii prolapse * interested in pfpt for management of pop * normal mammogram within 1 year of enrollment exclusion criteria: * prior surgery for prolapse or incontinence * other prior interventions for prolapse (e.g. pessary, pfpt) * previous bilateral salpingo-oophorectomy (women with 1 ovary will be eligible) * known liver dysfunction * connective tissue diseases known to affect collagen or elastin remodeling (including: lupus, rheumatoid arthritis, scleroderma, sjogrens syndrome, marfan syndrome, and ehlers-danlos syndrome) * unevaluated abnormal vaginal bleeding or abnormal pap smear in the previous year * bmi \> 35 kg/m2 * estrogen therapy (including birth control) in the previous year * current or prior breast or pelvic malignancy (ovarian, tubal, uterine, cervical or vaginal) * contraindication to hormone use (i.e. thromboembolic disorder, use of anti-coagulants, coronary artery disease, history of stroke)

Keywords: pelvic organ prolapse pelvic floor physical therapy vaginal estrogen placebo
photobiomodulation therapy in patients receiving total knee arthroplasty

Conditions: Inflammation; Osteoarthritis; Post Operative Pain

Summary: photobiomdoulation is the use of near-infrared light to relieve pain, stimulate healing and reduce inflammation. swelling and inflammation is a common condition after orthopedics surgeries over extremity and spine. this study aim to evaluate the effect of photobiomodulation over patients after total knee arthroplasty.

patients aged over 20 after total knee arthroplasty in our institution would be candidate for recruitment. the patients will be randomized to receive routine post operative care or photobiomodulation therapy. the swelling extent and subjective outcome will be recorded.

Eligibility criteria:
inclusion criteria: * total knee arthroplasty exclusion criteria: * open injury * pregnancy * wound without primary closure * infection * previous surgery over surgical site * skin defect
prognostic role of serum albumin level in radiological progression of gonarthrosis: is it a biomarker in itself? a biomarker associated with systemic inflammation?

Conditions: Gonarthrosis; Serum Albumin Low

Summary: the aim of our study is to evaluate the prognostic roles of serum albumin level and systemic inflammation-related indices, including and not including serum albumin level, in the radiological progression of gonarthrosis. in this retrospective study, between 10.01.2017 and 10.01.2022, the data of the patients between the ages of 50-80, who applied to ufuk university physical medicine and rehabilitation clinic with the complaint of knee pain and met the clinical criteria of the american rheumatology association for gonarthrosis (knee osteoarthritis) (knee pain on many days of the previous month, crepitation with active joint movement, morning stiffness lasting ≤ 30 minutes, age ≥38 years, bone enlargement of the knee on examination),and whose knee radiography and blood tests were evaluated at admission were scanned.


Eligibility criteria:
inclusion criteria: * in this retrospective study, between 10.01.2017 and 10.01.2022, the data of the patients between the ages of 50-80, who applied to ufuk university physical medicine and rehabilitation clinic with the complaint of knee pain and met the clinical criteria of the american rheumatology association for gonarthrosis (knee osteoarthritis) (knee pain on many days of the previous month, crepitation with active joint movement, morning stiffness lasting ≤ 30 minutes, age ≥38 years, bone enlargement of the knee on examination),and whose knee radiography and blood tests were evaluated at admission were scanned. in order to compare the parameters to be included in the study, the data and blood tests of patients between the ages of 50-80 who applied to ufuk university physical medicine and rehabilitation clinic between 10.01.2017 and 10.01.2022 for reasons other than knee pain were scanned. exclusion criteria: * in the patient and control groups, patients who were younger than 50 years of age, older than 80 years of age, had acute or chronic infection, malignancy, rheumatic disease or systemic diseases that could change the blood test parameters to be evaluated, and patients who were missing one or more of the blood test parameters planned to be evaluated among the data obtained were excluded from the study. in addition, in the patient group, patients who had neurogenic or internal organ problems that could cause pain referred to the knees, who were not required to have a knee x-ray when applying to the outpatient clinic, and who had a history of trauma to the knee area, invasive procedure or surgical intervention within the 6 months before admission to the outpatient clinic, were excluded from the study. in the control group, patients who complained of knee pain in addition to their complaints at admission were excluded from the study.