Kornimate/medical-research-clean huggingface dataset:
an open study to evaluate whether pack size affects compliance of metformin treatment in subjects with type ii diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: mtf116086 is an open-label, randomised, parallel-design study in subjects with type ii diabetes. the study is site-based, with local pharmacies serving as the sites and pharmacists as principal investigators for the sites. all subjects will enter an initial 8-week observational phase during which purchase behaviour and compliance with usual metformin use will be observed and recorded. at the end of the observational phase, subjects will be randomised to one of the two arms (metformin small pack vs. metformin large pack) for a 20-week interventional phase. the medication in the interventional phase is provided to the subjects free of charge. hba1c will be collected for all subjects during week 0, week 8, and week 28. subjects will be asked questions about their tablet compliance, their satisfaction with the pack size they received and reasons for missing doses throughout the interventional phase by the pharmacist. the pharmacy visit on week 28 will be end of the study.


Eligibility criteria:
inclusion criteria: * males and females of age \>=18 years * diagnosis of type ii diabetes * hba1c value no higher than 9.0% * evidence of physician-supplied prescription for metformin use * stable dose of metformin for 3 months prior to enrolment * written informed consent from the subject exclusion criteria: * current use of any anti-diabetic medication other than metformin

Keywords: socioeconomic category medication compliance metformin small pack
perioperative durvalumab with neoadjuvant ddmvac or gemcitabine/cisplatin in patients with muscle-invasive bladder cancer (niagara-2)

Conditions: Urinary Bladder Neoplasms; Immune Checkpoint Inhibitors; Methotrexate; Vinblastine; Doxorubicin; Cisplatin; Gemcitabine

Summary: the phase iiib niagara-2 study aims to expand on the data from the phase iii niagara study by investigating perioperative durvalumab in combination with investigator-selected cisplatin-based neoadjuvant chemotherapy (either ddmvac or gemcitabine/cisplatin) in a clinical practice setting.

not provided

Eligibility criteria:
inclusion criteria: * participants with clinical tumour stage t2-t4an0/1m0 or t1n1m0 with transitional or mixed transitional cell histology * patients must be planning to undergo radical cystectomy * patients who have not received prior systemic chemotherapy or immunotherapy for treatment of muscle-invasive bladder cancer * ecog performance status of 0 or 1 * minimum life expectancy of 12 weeks at first dose of study medication exclusion criteria: * evidence of lymph node (n2-n3) or metastatic (m1) disease * inoperable tumour(s) with fixation to the pelvic wall on clinical examination * prior exposure to immune-mediated therapy including, but not limited to, other anti ctla-4, anti-pd 1, anti-pd l1 and anti-pd-l2 antibodies, excluding bacillus calmette-guérin * current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab * any concomitant medication known to be contraindicated to the chemotherapy (ddmvac or gem/cis). * uncontrolled intercurrent illness.

Keywords: muscle-invasive bladder cancer bladder cancer immunotherapy durvalumab perioperative durvalumab ddmvac gemcitabine cisplatin
grem1, has2 and ptgs2 gene expression following the in vitro maturation (ivm)

Conditions: Increased Oocyte Death; in Vitro Maturation; GREM1 Gene Mutation; Cumulus Cell

Summary: poor ovarian reserve (por) is an adverse prognostic factor for in-vitro fertilization (ivf) success. numerous established data showed low live birth rates per ivf cycle; 6 to 10%, including the usage of in-vitro maturation (ivm). in malaysia, por incidence increases mainly from cancer survival, endometriosis, and autoimmune diseases women; therefore, ivm implementation is paramount. in the molecular level, the low competence oocytes showed a low expression of grem1, has2 and ptgs2 in human cumulus cells, thus leading to poor oocyte quality(oq). various ivm media had been formulated to enhance the competency and quality of the oocytes to date. therefore, our study aims to elucidate the grem1, has2 and ptgs2 gene expression as oocyte developmental competency markers among por women following ivm and tailored to the ivf outcome.

in this study, we will follow up the normal and por women. the discarded product - cumulus cell will be used in this study for evaluation following the standard ivf cumulus-oocyte-complex denudation. we will develop the in-vitro model to assess the expression of grem1, has2, and ptgs2 in normal and por women first. subsequently, these gene expressions will be reassessed again via clinical model using ivf-ivm cumulus cell comparing the both groups to elucidate the modifying of oocytes quality following ivm. the cumulus cell rna will be extracted,and the cdna will be synthesized and quantitated. the rt-pcr standard curves will be produced, and the concentration range of these genes will be generated and quantified. the oq, embryo morphology scoring, fertilization rates, and live birth rates will be recorded and compared. we anticipate a higher gene expression associated with good oq thus better fertilization and live birth rate. therefore, this research will understand the impact of ivm in oocytes competency, aiming to improve the fertility rate among por women in malaysia.

Eligibility criteria:
inclusion criteria: * women underwent ivf with normal and poor ovarian reserve based on the bologna criteria( anti-müllerian hormone (amh) below 0.5-1.1 ng/ml\]). exclusion criteria: * male factor infertility (to reduce bias for embryo quality factor) * not agree to participate.

Keywords: cumulus cell grem 1 gene expression has 2 gene expression ptgs 2 gene expression oocyte quality in vitro maturation
the effect of kinesio-tape® on pain and vertical jump performance in active individuals with patellar tendinopathy

Conditions: Patellar Tendinitis

Summary: background: patellar tendinopathy is a common inflammatory condition in athletes who undergo large volumes of running and jumping. kinesio-tape® (kt) is proposed to provide pain relief; however, its effect has not been examined on patellar tendinopathy. objective: to examine the effects of kt on pain modulation for active individuals with patellar tendinopathy during functional activities. methods: thirteen symptomatic knees from seven college-aged females (6 bilateral; 1 unilateral) were included. participants underwent three data collection sessions with kt, sham, and no tape (nt) in a randomized order. during the session, participants performed a maximum vertical jump, single-leg squats and isometric knee extension. the kt intervention was applied according to the kt manual and the sham utilized the same pattern without tension. pain level was evaluated using the numeric pain scale before, during and after each activity. function was assessed as maximum vertical jump height and maximum isometric strength.


Eligibility criteria:
inclusion criteria: * anterior knee pain that increases with jumping and/or squatting * pain with palpation at the tibial tuberosity, the patellar tendon, and/or at the apex of the patella * an insidious onset of this pain. * participate in physical activity at least 3 days a week exclusion criteria: * injury from direct trauma to the anterior knee * medical history of surgery at the knee joint within the past 6 months * presence of any lower extremity injuries or non-orthopedic diseases * suspected or confirmed pregnancy.
factor influencing breast surgery type decision-making

Conditions: Breast Neoplasm

Summary: the aim of this observational study is to determine the factors influencing the decision-making process for breast surgery type, in lebanese women likely to face breast cancer. the main questions it aims to answer are the presence or not of a correlation between the type of choice and the following data: * demographic * health status * several factors that may influence the decision participants will complete a well-structured and organized online survey


Eligibility criteria:
inclusion criteria: * lebanese females exclusion criteria: * none

Keywords: breast cancer mastectomy breast conserving surgery lebanese population surgical choice oncoplastic surgery
postop catheterization for urinary retention

Conditions: Urinary Retention

Summary: this study investigates patient's preference and satisfaction with choice of catheterization after surgical urogynecological procedures.

preoperatively, the enrolled patient receives information about risks and benefits of three ways of bladder catheterization as means of management of postoperative urinary retention. based on this information, the patient chooses her preferred way of postoperative catheterization in case she experiences acute urinary retention after surgery. after the surgery, those patients requiring catheterization postoperatively evaluate their experience in a postoperative questionnaire.

Eligibility criteria:
inclusion criteria: * all female patients who undergo urogynecological surgery procedures at northshore university healthsystem and consent to participate exclusion criteria: * patients who cannot read, comprehend, and write in english
a multiple dose safety and pharmacokinetic (pk) study of pf-06427878 in overweight-obese, otherwise healthy subjects

Conditions: Healthy Volunteers

Summary: pf-06427878 is a new compound proposed for the treatment of hyperlipidemia. the primary purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics after 2 weeks of dosing of pf-06427878 in overweight-obese, otherwise healthy adult subjects.


Eligibility criteria:
inclusion criteria: * healthy male and/or female subjects of non childbearing potential. * body mass index (bmi) of \>=25 kg/m2; and a total body weight \>50 kg * subjects with liver fat \>=6% and \<=20% exclusion criteria: * evidence or history of clinically significant hematological, renal, endocrine, pulmonary,gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing).

Keywords: hyperlipidemia
effect of intravenous lidocaine on propofol requirements

Conditions: Analgesia

Summary: lidocaine, an amide local anesthetic, has advantages of low price and easily obtaining. intravenous lidocaine (ivl)initially has been used in the treatment of arrhythmia. it was demonstrated that ivl had analgesic effect, especially in colorectal surgery, but remained controversy in other types of surgeries. other beneficial effects, such as prevention of hyperalgesia and propofol-induced injection pain, reduction of incidence of postoperative ileus and nausea and vomiting and anti-inflammatory also were proposed.

the most frequent drugs for procedural sedation and analgesia are propofol, benzodiazepines and opioids. however, these drugs may cause respiratory depression and circulatory instability. combination will increase the risk of hypoxia and apnea. in china, most anesthesia for hysteroscopy and gastroenteroscopy is procedural sedation and analgesia(pas) provided by anesthetists. foester et,al. have been tested that ivl could significantly reduce propofol requirements 、postoperative pain and fatigue scores in colonoscopy. chen,et,al. find the same effect of ivl in elderly. however, there is no research reporting ivl used in hysteroscopy and diagnostic curettage. so, our main objective is to evaluate the effect of intravenous lidocaine on propofol requirements in patients undergoing hysteroscopy and diagnostic curettage.

Eligibility criteria:
inclusion criteria: * patients who underwent hysteroscopy and diagnostic curettage, american society of anesthesiologist' physical status 1-2, bmi 18.5-24.9 kg/m2, exclusion criteria: * patients with known allergy to lidocaine or other local anesthetics, taken sedatives and analgesics within 1 week before surgery, mental and neurological diseases, hearing impairment, unwilling to sign informed consent or participate in the study, serious arrhythmia and organic heart disease.

Keywords: intravenous lidocaine propofol pain score fatigue score dose
building closer friendships in social anxiety disorder

Conditions: Social Anxiety

Summary: this study assesses whether a 4-week computerized intervention can be used to decrease fear of intimacy, and loneliness and improve perceived social support in people with social anxiety disorder.

this study hopes to assess whether a month long computerized intervention aimed at giving people skills to form closer friendships. participants will be randomized into an active treatment condition or a wait list control. we hypothesize that 1) participants in the treatment condition will have lower fear of intimacy at post treatment than those in the waitlist condition 2) participants in the treatment condition will have lower levels of loneliness than those in the waitlist condition 3) participants in the treatment condition will have higher perceived social support than those in the waitlist condition.

Eligibility criteria:
inclusion criteria: * social anxiety disorder diagnosed by the mini international neuropsychiatric interview * social phobia inventory score \>19 * stable psychotropic medication for the past month and kept stable for duration of study exclusion criteria: * currently participating in therapy * current substance dependence * bipolar disorder or psychotic illness * current suicidality (imminent risk)
airway inflammation in patients with chronic obstructive pulmonary disease

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this study was designed to look at effects of salmeterol/fluticasone propionate compared to placebo on airway inflammation in patients with chronic obstructive airways disease


Eligibility criteria:
inclusion criteria: * established clinical history of chronic obstructive airways disease. * must be current or ex-smokers with a smoking history of at least 10 pack-years (e.g. 20 cigarettes/day for 10 years or 10 cigarettes/day for 20 years). * must have reduced lung function, defined as a forced expiratory volume in 1 second (fev1) of between 40-80% of predicted normal values. exclusion criteria: * diagnosis of any other serious disease and must have a chest x-ray to eliminate a diagnosis other than copd.

Keywords: airways pulmonary obstructive chronic inflammation salmeterol/fluticasone propionate
study evaluating bazedoxifene acetate in osteoporosis in postmenopausal women

Conditions: Osteoporosis

Summary: the purpose of this study is to determine whether bazedoxifene acetate is safe and effective in the treatment of osteoporosis in postmenopausal women.


Eligibility criteria:
inclusion criteria: * must be at least 2 years postmenopausal * osteoporotic subjects without vertebral fracture who meet bmd criteria, or osteoporotic subjects with vertebral fracture exclusion criteria: * diseases that may affect bone metabolism * vasomotor symptoms requiring treatment * known history or suspected cancer of the breast * active or past history of venous thromboembolic events

Keywords: osteoporosis postmenopause
frailty and surgery

Conditions: Frail Elderly Syndrome

Summary: frailty has been recently re-defined as a condition that is evident over time through an excess of vulnerability to stressors, with reduced ability to maintain or regain homeostasis after a destabilizing event, and occurrence of disability. frailty has been often used to characterize the weakest and most vulnerable subset of older adults, because of age, comorbidities, social and emotional status leading to the lack of functional and psychological reserve and mining the capability to face acute events. frail patients are becoming ever more present in anesthesia and intensive care. in fact, 30 percent of surgery is conducted on patients ≥ 70 years old nowadays. it has been demonstrated that the impact of surgery and anesthesiologic risk are greater in older frail subjects, and that a low functional status is associated with increased mortality. also, post-operative delirium and cognitive disfunction are more often seen in older patients. for this reason, the worsening of the global performance status, as functional status, mobility, and cognitive status may have a large impact on patient and caregivers' life. the primary objective is to evaluate the impact at three months after hospitalization following major surgery i.e., urology, general surgery, orthopedics, on the performance status as functional status, mobility, and cognitive status of patients ≥ 70 years old. secondary objectives are to evaluate the necessity of domiciliary care assistance and re-hospitalization or rehabilitation center admissions in three months following surgery and to evaluate the impact of the type of anesthesia used in major surgery i.e., general vs regional anesthesia, on patient performance status.


Eligibility criteria:
inclusion criteria: * ≥ 70 years old * listed for major surgery in general and vascular surgery, urology, orthopedics * patient general practitioner listed in the local health authority of novara exclusion criteria: * barthel index at baseline \< 16 in the activities of daily living section * barthel index at baseline \< 11 in the mobility section * mini mental state examination at baseline \< 11
effect of multisensory stimulation on upper extremity motor recovery in stroke patient: a preliminary testing

Conditions: Stroke

Summary: despite the advances in stroke rehabilitation, post-stroke upper extremity impairment is still a major challenge. increasing evidence can be found supporting stimulation of the afferent receptor enhances neuroplasticity in the brain. studies have suggested multisensory stimulation could promote motor learning by re-establishing the disrupted sensorimotor loop due to stroke and enhance neuroplasticity. the objective of the study was to examine the effect of multisensory stimulation on upper-extremity motor recovery and self-care function in stroke patients.

stroke patients referred to occupational therapy division of geriatric day hospital will be recruited and randomly assigned to a multisensory therapy group or a conventional training group. the multisensory therapy group received 12 weeks (two sessions/ week; 90 minutes/session) training. each session began with 15 minutes of sensory stimulation (cold and vibration), 45 minutes of motor training and 30 minutes of self-care training. the conventional training group included 12 weeks (two sessions/ week; 90 minutes/session) training. each session included 60 minutes of upper extremity motor practice and 30 minutes of self-care training. outcome measures included: brunnstrom's stage, fugl-meyer assessment scale and functional test for the hemiplegic upper extremity were used for upper limb motor control and function; and manual muscle testing was used for muscle strength. the modified barthel index was used for self-care performance

Eligibility criteria:
inclusion criteria: * first-time ischemic or hemorrhagic stroke; * stroke onset \> 4 weeks and \< 6 months * single lesion * upper extremity motor deficit * no severe cognitive impairment and able to follow verbal instructions. exclusion criteria: * skin conditions/ injuries over the stimulation application areas * contraindication for cold or vibration application * speech disorder or global aphasia * musculoskeletal or cardiac disorders * other neurological conditions * history of diabetes or sensory impairment attributable to peripheral vascular disease or neuropathy

Keywords: multisensory stimulation; motor recovery
evaluation of the association between depression and glycemic control in people with type 1 diabetes

Conditions: Type 1 Diabetes

Summary: single-center prospective observational pilot study the aim of the study is to evaluate the potential association between the percentage of time spent in the optimal glycemia range and the score obtained in the questionnaires used to screen for depression. the study involves only one visit for each participant. each participant will be asked to sign the informed consent to the study and, during the visit, the following information will be acquired: parameters, history of diabetes, concomitant diseases and medications, and cgm metrics. the participant will be administered the following questionnaires for the evaluation of depression, patient-reported outcome measure (proms) and treatment satisfaction: * patient health questionnaire (phq-9) * center of epidemiological studies-depression scale (ces-d) * diabetes treatment satisfaction questionnaire (dtsq) * well-being index (who-5) * problem areas in diabetes (paid-5) * european quality of life, five dimension, five level (eq5d5l)


Eligibility criteria:
inclusion criteria: 1. informed consent before any activity foreseen by the protocol 2. age \> 18 years 3. subjects with type 1 diabetes mellitus, both on multiple daily injection and with insulin pump, using glucose monitoring systems, both flash glucose monitoring and continuous glucose monitoring exclusion criteria: 1. type 2 diabetes mellitus or other forms of diabetes, such as steroid-induced or secondary to pancreatectomy, pancreatitis, or secondary to endocrinological disorders 2. previous diagnosis of major depression, bipolar disorder, psychotic disorder, eating disorder (anorexia nervosa, bulimia nervosa, binge eating disorder) 3. chronic treatment with corticosteroids 4. bmi \<19kg/m2 5. known history of substance or alcohol abuse 6. patients who have recently been admitted to the psychiatry ward or are being treated with psycho-drugs 7. conditions that do not allow participation in the activities envisaged by the protocol