Kornimate/medical-research-clean huggingface dataset:
vitamin d supplementation for the prevention of acute respiratory tract infections

Conditions: Respiratory Tract Infections

Summary: the investigators earlier clinical study in 754 young finnish men demonstrated a significant negative association of serum 25-ohd concentration with acute respiratory tract infections. the present study aimed to determine whether vitamin d supplementation may decrease the incidence of acute respiratory tract infections.

subjects comprised 164 male conscripts at a military base in finland. half of the participants were randomly allocated to receive 400 iu vitamin d daily and half received placebo from october through march. serum vitamin d and plasma parathyroid hormone concentrations were determined. subjects were followed for 6 months and the primary outcome was the number of days absent from duty due to arti.

Eligibility criteria:
inclusion criteria: exclusion criteria: * use vitamin d

Keywords: vitamin d infection vitamin d for the prevention of respiratory tract infections
home walking exercise training in advanced heart failure

Conditions: Heart Failure; Functional Status; Quality of Life

Summary: heart failure is a major public health burden in the united states characterized by increased morbidity and mortality, and reduce exercise capacity with distressing symptoms of dyspnea and fatigue. evaluating the effects of complementary intervention (such as exercise training) on functional status and qol are clinically important and relevant to hf patients. in the last decade, hospital-based and a home bicycle exercise programs for hf have been shown to improve peak oxygen consumption (vo2) and symptom scores, and restore autonomic balance. these programs may be costly for patients to perform. improved peak vo2 may not necessarily translate into improved functional status and quality of life. to date, the effects of a home walking exercise program alone on functional status, qol and autonomic tone has not been evaluated.

background: heart failure is a major public health burden in the united states characterized by increased morbidity and mortality, and reduce exercise capacity with distressing symptoms of dyspnea and fatigue. evaluating the effects of complementary intervention (such as exercise training) on functional status and qol are clinically important and relevant to hf patients. in the last decade, hospital-based and a home bicycle exercise programs for hf have been shown to improve peak oxygen consumption (vo2) and symptom scores, and restore autonomic balance. these programs may be costly for patients to perform. improved peak vo2 may not necessarily translate into improved functional status and quality of life. to date, the effects of a home walking exercise program alone on functional status, qol and autonomic tone has not been evaluated. objectives: the specific aim was to compare functional status (fs), quality of life (qol) and autonomic tone in 2 groups of advanced hf patients (nurse-managed home walking exercise (hwe) group vs. control group). methods: a randomized controlled trial comparing a 12-week nurse-managed progressive hwe protocol to usual activity was conducted in 79 hf patients (78\[99%\] male; mean age 62.6 � 10.6 years; ef 27 � 8.8%; 63 \[80%\] nyha ii, 15\[20%\] nyha iii-iv; hf duration 39.2 � 41.8 months) from a va medical center and a university affiliated medical center. the 12- week hwe program is once a day, 5x a week and initiated at 10 minutes and progressively increases in duration and intensity up to 60 minutes. pre- and post-study measures were fs (peak vo2 and ventilatory threshold via cpx, 6-minute walk test (6mwt) and a heart failure functional status inventory (hffsi)), qol (cardiac quality of life index (c-qli), sf-36, and dyspnea-fatigue index (dfi) with global rating of symptoms), and autonomic tone (norepinephrine (ne) and heart rate variability (hrv)). intention-to-treat analysis with repeated measures anova was used to identify group differences. status: completed.

Eligibility criteria:
inclusion criteria: should have a stable heart failure in the past 3 months (max age is 80) exclusion criteria:
imatinib mesylate treatment of patients with malignant peripheral nerve sheath tumors

Conditions: Malignant Peripheral Nerve Sheath Tumors

Summary: this study assesses the safety and efficacy of imatinib mesylate treatment of patients with malignant peripheral nerve sheath tumors


Eligibility criteria:
inclusion criteria: * patients ≥18 years of age * histologically documented diagnosis of malignant mpnst * unresectable local mpnst or metastatic mpnst and therefore incurable with any conventional multimodality approach life expectancy of at least 6 months. exclusion criteria: * patient has received any other investigational agents within 28 days of first day of study drug dosing. * chemotherapy and or radiotherapy in between the last 6 weeks before study entry, surgery in between the last 14 days before study entry. * female patients who are pregnant or breast feeding or women of child bearing potential who are not using a highly effective method of birth control. * known cns metastases other protocol-defined inclusion/exclusion criteria may apply.

Keywords: malignant, peripheral, nerve sheath tumors, mpnst, neurofibromatosis, nf1, imatinib mesylate
contribution of per dialytic physical activity in chronic dialysis patients

Conditions: Dialysis

Summary: dialysis patients have reduced walking capacity and an important risk of high blood pressure. these complications are associated with a decline in quality of life and increased mortality. the hypothesis of the study is to show that physical activity during the dialysis session in dialyzed patients has a benefit on quality of life, as well as on muscle, cardiovascular and dialysis parameters.

dialysis patients have reduced aerobic capacity, walking ability, and an increased risk of hypertension. these complications are associated with a decline in quality of life and increased mortality. since asthenia is too intense after the dialysis session, patients are encouraged to perform physical activity during dialysis sessions. some studies have shown that physical activity during dialysis can have benefits on quality of life and improve muscle parameters, but without this being clinically significant. other studies show no benefit. the objective of the study is to explore the benefits of physical activity on quality of life, muscle parameters, and biological and dialysis parameters in a cohort of compliant hemodialysis patients.

Eligibility criteria:
inclusion criteria: * adults aged 18 and over, undergoing chronic hemodialysis at chi andré grégoire for more than 3 months. * consent to participate in physical activity during dialysis sessions. * written informed consent. * affiliation with a social security system exclusion criteria: * lower limb amputation without a prosthesis. * non-healed foot wounds. * hemoglobin \< 8 g/dl. * patient refusal to participate. * severe respiratory (oxygen dependence) or cardiac disease (nyha class 3 or 4, lvef \< 30%). * advanced dementia or psychiatric illness impeding cooperation, or refusal to consent. * non-french speaking patients unable to understand the study. * patients under guardianship. * advanced osteoarthritis, recent hip or knee prosthesis (\< 3 months). * hypotension (bp \ 180/110 mmhg). * fever (temperature \>= 38°c). * hypoglycemia (fingerstick glucose \< 0.8 g/l) in diabetic patients. * dyspnea or desaturation in ambient air \< 95%. * covid-19 symptoms within the last 21 days, positive pcr test, unable to pedal. * chest pain or unstable angina. * muscle or joint contraindications to the pedal exerciser as assessed by a physiotherapist

Keywords: dialysis patients physical activity
plantar callosities and the validity of body composition assessment by bio-impedance in severely obese persons

Conditions: Obesity, Morbid

Summary: studies have confirmed the association between plantar callosities and severely obese individuals. bioelectrical impedance analysis (bia) is an increasingly popular tool for estimating body composition because it is easy to use, noninvasive, relatively inexpensive, and can be performed across a wide range of subjects. our hypotheses for this study are: (1)plantar callosities influence the body composition measurements obtained by bioelectrical impedance analysis bia, and (2) bia underestimates the percentage of body fat compared with air-displacement plethysmography (bodpod).

as the prevalence of obesity continues to increase, many parts of the world are progressively facing a rise in the number of people who fall under who obesity class 2 and 3. since severe obesity is characterized by large alterations in body compartments when compared to overweight or non-obese individuals, there is a need for the evaluation of the body composition of severely obese persons. there is very few published research available on what methods of body composition measurements can be used on this population. other studies have also shown the tendency of bioelectrical impedance analysis (bia) instruments to underestimate percentage of fat mass and overestimate the percentage of fat free nass, compared with gold-standard techniques. we think that plantar callosities might have contributed to the lack of accurate measurements. thus, the primary aim of this study is to determine whether plantar callosities influence the validity of body composition measurements obtained by bia, using the inbody 720. the secondary aim is to assess the validity of the body composition measurements obtained by bia (inbody 720) in severely obese individuals, using air-displacement plethysmography (bodpod) as the gold standard. additionally, we will explore various sources of error using test-retest reliabilities by measuring body composition with different arm postures. we will examine this further to rule out the possibility of "positions of measurement" as a potential confounder of this study.

Eligibility criteria:
inclusion criteria: * adults (18-50 years old) * class 2 and 3 obesity (bmi \> 35 kg/m2) * moderate to severe callosities exclusion criteria: * intractable plantar keratosis (ipk), which are painful plantar calluses located under the metatarsal heads. * pregnancy * menopause * diseases that cause water retention (edema, renal insufficiency, hypertension, etc.)

Keywords: body constitution anthropometry electric impedance
evaluation genotypic, phenotypic and prognosis apeced syndrome

Conditions: APECED

Summary: the objective of the study will define the mutational spectrum in this french cohort, in patients with apeced syndrome genetically authenticated


Eligibility criteria:
inclusion criteria: * patients with at least 2 major criteria out of the following 3: hypoparathyroidism of autoimmune origin, adrenal insufficiency of autoimmune origin, chronic cutaneous and mucosal candidiasis. * patients with only 1 of the 3 major criteria, associated with at least 2 of the following minor criteria: hypergonadotropic hypogonadism of autoimmune origin, atrophic gastritis, malabsorption, autoimmune hepatitis, vitiligo, alopecia, chronic keratoconjunctivitis, hypoplasia of dental enamel. * patients whose molecular diagnosis has been established or who will be established during the inclusion visit with the genetic sample. exclusion criteria: -
flash-free brackets and dental plaque

Conditions: Orthodontic Treatment

Summary: this study aimed to compare flash-free bracket system with conventional adhesive-coated bracket system in patients with maxillary crowding.

aim: the aim of this split-mouth study was to compare conventional and adhesive flash-free-bracket systems in terms of plaque retention, white spot lesion formation, biomarker levels and select microbes in gingival crevicular fluid (gcf). materials \& methods: thirty-seven systemically healthy patients (18 males, 19 females) with the age range of 13-18 years were involved in this split-mouth study. clinical evaluations, quantitative light-induced fluorescence (qlf) imaging, gcf and plaque samplings were performed at baseline and at 1-, 2-, 3-months. qlf was repeated following debonding, gcf samples were analyzed by immunoassay and real-time pcr for the biomarker and bacteria content. data were analyzed by wilcoxon on dependent samples.

Eligibility criteria:
inclusion criteria: * being systemically healthy * having 4-7 mm maxillary crowding with a maximum of 2 mm linear displacement of contact points and non-extraction treatment planning. exclusion criteria: -
polymorphids an mrna expression in obese genes

Conditions: Polymorphism; mRNA Expression

Summary: fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (gbp). are there any difference in polymorphids and/or mrna expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 . are there any difference in polymorphids and/or mrna expression in different types of fat tissue


Eligibility criteria:
inclusion criteria: * age 18 years or older * laparoscopic surgery (gastric by-pass, cholecystectomy, antireflux surgery) * normal weight without type 2 diabetes bmi 18-25 * obese without type 2 diabetes bmi\>35 * obese with type 2 diabetes bmi\>35 exclusion criteria: * under 18 years * open surgery * pregnancy * bmi \>27-\<35
simplification from protease inhibitors to raltegravir

Conditions: HIV Infections

Summary: a switch from protease inhibitors (pis) to raltegravir (ral) will be effective virologically and immunologically. moreover, it will be associated with significant improvements in the lipid profile in hiv patients with undetectable viremia on pis. in this setting, ral once a day (qd) will perform as well as ral twice a day (bid).


Eligibility criteria:
inclusion criteria: * hiv1 sero-positive using standard diagnostic criteria * plasma viral hiv-rna below 50 copies/ml within 180 days prior to randomization * on therapy with protease inhibitors both ritonavir-boosted or un-boosted for at least 6 months prior to study entry exclusion criteria: * pregnancy or breast feeding * prior use of integrase inhibitors * alcohol or substance abuse if according to the investigator opinion would interfere with compliance * uise of investigational medications within 30 days before study entry or during the trial

Keywords: simplification from protease inhibitors to raltegravir treatment experienced hiv-1 infections
screening effect of dual-energy ct combined with nasopharyngeal endoscopy for screening nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: all participants will be tested for ebv-related biomarkers, including ebna1-iga, vca-iga, and bnlf2b total antibody (p85-ab), and participants with high serologic risk will be selected based on serologic test results, and dual-energy ct will be performed first for high-risk screening subjects, and dual-energy ct will be performed first for the high-risk group to record dual-energy ct examinations of those suspected of nasopharyngeal carcinoma, and then endoscopy was performed on the high-risk group to record those suspected of nasopharyngeal carcinoma under endoscopy, and finally biopsies were taken for positive lesion sites indicated by dual-energy ct and suspicious lesion sites found by endoscopy to clarify the diagnosis.


Eligibility criteria:
inclusion criteria: * subject residents in zhongshan city * subject has no medical record of nasopharyngeal carcinoma * subject is able to comprehend, sign, and date the written informed consent document to participate in the study * subject has psychical condition and well consciousness, and also accept and cooperate with the follow-up of this study exclusion criteria: * subject has heavy cardiovascular, liver or kidney disease * subject has contraindications to nasopharyngeal endoscopy * subject has contrast media allergy

Keywords: screening nasopharyngeal carcinoma dual-energy ct endoscopy
the prognostic assessment of extubation in aged patients with multiple organ dysfunction syndrome

Conditions: Multiple Organ Dysfunction Syndrome

Summary: the multiple organ dysfunction syndrome (mods) has remained the major factor contributing to prolongation of intensive and mortality. it is reported that the mortality rates have varied between 20% and 100%, depending on number, severity, duration, type and combination, and definition of dysfunction. in our study, the investigators explore some comprehensive treatment technology to improved outcomes of mods patients.


Eligibility criteria:
inclusion criteria: * age \> 60 years old; * presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention; * have trachea intubation after admitting to intensive care unit within 24 hours. exclusion criteria: * end stage multiple organ failure.

Keywords: aged multiple organ failure extubation prognosis mods invasive mechanical ventilation
macroscopic deciduosis in pregnancy is finally a common entity

Conditions: Deciduitis; Complicating Pregnancy

Summary: the purpose of this study is to determine the prevalence of macroscopic deciduosis found randomly in cesarean sections and the secondary objective to determine the association with any obstetrical complications or adverse effects.

ectopic decidua or deciduosis is defined as the extrauterine location of decidual tissue and can occur in the cervix, vagina and various abdominal organs like the ovary omentum, appendix, peritoneum, the pelvic lymph nodes. other rare sites with deciduosis include the kidneys , the lungs and even the skin . decidualization is a physiologic process during pregnancy, under the influence of ovarian and placental steroid secretion, with total involution in the four to six week post partum period.

Eligibility criteria:
inclusion criteria: * all cesarean section exclusion criteria: * patients refusing to participate

Keywords: frequency macroscopic deciduosis ovarian neoplasm pregnancy
vaccine -diphtheria -tetanus -acellular pertussis-inactivated poliovirus

Conditions: Diphtheria; Tetanus; Pertussis; Poliomyelitis

Summary: the objective of this study is to assess the immunogenicity and safety of the dtap-ipv combination vaccine compared with those of separate dtap and ipv vaccines administered to healthy infants at 2, 4, and 6 months of age.

a multinational, multicenter, randomized, comparative, open-label, phase 3 study primary objective: to assess the vaccine response rates after the three-dose primary vaccination secondary objectives: to measure the antibody titer after the three-dose primary vaccination and to assess the safety of the investigational products

Eligibility criteria:
inclusion criteria: * parent/guardian (legally authorized representative) has given voluntary written consent to the subject's participation after being fully informed of the purpose, methods, risks, and benefits of the study. * male and female infants reaching at least 7 weeks of age on the day of first dose of investigational product. * male and female infants who are identified to be healthy based on physical examination and medical history. exclusion criteria: * subjects who have acute febrile illness with tympanic temperature of ≥38.0 ℃ on the day of vaccination. * subjects who have moderate or severe acute disease (regardless of fever). * subjects who have any history of diphtheria, tetanus, pertussis, or poliomyelitis. * subjects who have major congenital defects. * subjects who show any evidence of continuous hematologic, hepatic, cardiac, re-nal, or respiratory disease. * subjects who have abnormalities in the immune system, or congenital/acquired immune deﬁciency. * subjects who received immunosuppressive dose of systemic corticosteroids thera-py within 30 days before the vaccination. * subjects who are likely to have adverse side effects on central nervous system be-cause of the subjects' family history of genetic diseases in central nervous system such as progressive neurological problems or epilepsy. * subjects who are allergic to the ingredients of the investigational products. * subjects who have received immunoglobulins or blood products or plan to get those medications. * subjects who have received vaccines other than those allowed in the protocol or plan to get those prohibited vaccines during the study period. * subjects who are currently participating or planning to participate in other clinical studies during the study period. * other ineligible conditions judged at the discretion of principal investigators or subinvestigators.
a bedside portable endoscopy for the esophageal foreign body

Conditions: Esophageal Foreign Body

Summary: the purpose of this study is to determine whether a bedside portable endoscopy is effective in identifying the esophageal foreign body in the emergency room.


Eligibility criteria:
inclusion criteria: * patients who visit the emergency room due to apparent foreign body in esophagus exclusion criteria: * patients unable to insert a portable endoscopy through the nasal cavity * patients unable to undergo conventional esophagogastroduodenoscopy for a gold standard examination
reduced ultrasound counts in rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra) is a chronic inflammatory disease characterized by intra and peri-articular synovial inflammation. synovitis can damage the articular cartilage, bones, joint capsule, tendons and ligaments leading to the consequential functional joint deterioration. the main goal of ra treatment is to achieve disease remission. the treatment of ra consists of synthetic and biologic disease modifying drugs (dmards), being the second ones selected when low disease or remission is not achieved with the first ones. therapeutic response monitoring in ra should be closely managed. it is classically based on clinical exploration and laboratory tests. during the last decade, the resolution improvement of musculoskeletal ultrasound (msus) imaging has led to the gradual incorporation of this technique in the evaluation and monitoring of patients with ra, mainly due to its better capacity to detect synovitis than clinical exploration . ultrasound imaging is highly available, non-invasive, reproducible, affordable and well accepted by patients. ultrasound doppler mode detects pathological synovial flow, which reflects synovial inflammation and has a demonstrated sensitivity to change in multiple longitudinal studies. sonographic evaluation of patients with ra includes the detection of synovitis in b and doppler mode in the joints accessible by ultrasound. there has been high variability in the literature regarding the number of joints that should be evaluated for an appropriate monitoring of the ra patients. the validity for monitoring the therapeutic response in long standing ra has been demonstrated in three reduced joint counts, including 12, 7 and 6 joints. however, in shorter evolution ra, the sensitivity to change of any of these reduced ultrasound evaluations has never been studied

primary objectives • to evaluate the sensitivity to change of the doppler ultrasound evaluation of 12, 7 and 6 joints counts in ra patients with more than 6 months and less than 5 years of evolution, which initiate an effective treatment for the disease according to indication (biologic dmard in monotherapy or combined with methotrexate).

Eligibility criteria:
inclusion criteria: * patients of both genders, ≥ 18 years of age * patients diagnosed with ra (according to the acr 2010 criteria) with more than 6 months and less than 5 years of active evolution and das28 \> 3.2 or sdai \> 11, which start treatment with biologic dmard for the first time, according to the product's summary of products characteristics (spc). * patients who have granted their written informed consent for the collection and review of their data. exclusion criteria: * patients who are already participating in a clinical trial/s at the moment of participation in this study. * patients with rheumatic disease other than ra

Keywords: rheumatoid arthritis ultrasound joint count