Kornimate/medical-research-clean huggingface dataset:
a study of a smartphone-based intervention for suicidal inpatients

Conditions: Suicide, Attempted; Suicidal Ideation; Hopeless

Summary: suicide is the most common form of deadly violence. indeed, since more than 40,000 people die by suicide each year, people are 2.5 times more likely to die by their own hand than someone else's. the four weeks after discharge from inpatient care is an especially dangerous period in terms of suicide risk, possibly because of poor post-discharge treatment adherence and poor treatment efficacy during a suicide crisis. to reduce suicide risk both in general and during the post-discharge period, interventions are needed that (1) are easily adhered to and (2) are effective during a suicide crisis. the goal of the study is to pilot-test a suite of five smartphone-based ecological momentary interventions (emi) that can be easily used during a suicide crisis. two target hopelessness, two target loneliness, and one targets negative automatic thoughts associated with hopelessness and loneliness. although these interventions are new to the study of suicide, they are all grounded in decades of empirical work and adapted from effective interventions in areas relating to suicide. participants will be 20 inpatients (n = 10 each in treatment as usual \[tau\] plus intervention and tau plus assessment \[i.e., control\] groups) from the massachusetts general hospital inpatient psychiatric service. the investigators hypothesize that those in the tau plus intervention group will have lower levels of suicidal ideation during the inpatient and post-discharge period than those in the tau plus assessment group.


Eligibility criteria:
inclusion criteria: * inclusion criteria include a recent (i.e., was included as the reason for admission) suicide attempt or serious suicidal ideation (i.e., ideation with at least 50% intent, assessed through either an explicit mention in the intake summary of intent greater than 50% or through this intent being inferred by clinical staff or in the notes \[for example, if the patient notes they wanted to die more than they did not want to die during the attempt or episode of suicidal ideation\]), english fluency, and access to an internet-capable smartphone (e.g., iphone or android). exclusion criteria: * exclusion criteria include any factor that impairs the ability to effectively participate in the study (e.g., intellectual abilities that are too low to understand the study and/or consent process) or a diagnosis of any schizophrenia-spectrum or psychotic disorder. * additionally, patients who are on involuntary hospitalization status will be excluded.

Keywords: suicide
alster stem cells - intramyocardial stem therapy

Conditions: Acute Myocardial Infarction; Early Left Ventricular Dysfunction

Summary: study to assess the efficacy of intramyocardial bone marrow derived mononuclear cell therapy concerning left ventricular ejection fraction as measured by echocardiography.


Eligibility criteria:
inclusion criteria: * lvdf \< 45% after timely (max. 6 hours after the onset of symptomps) successful pci * conventional therapy according to the esc guidelines for heart failure * bmi \> 20 and \< 35 exclusion criteria: * pci elder then 21 days * relevant valvular disease * history of stroke/multivessel disease/thromboembolic event etc. * dm type i * pregancy
single-implant overdentures retained by the novaloc attachment system

Conditions: Edentulous Mouth; Edentulous Jaw

Summary: the objective of this explanatory mixed methods study is to compare a novel attachment system (novaloc) to a traditional alternative (locator) for single implants in the mandible of edentate elders. the investigators will carry out a randomized cross-over clinical trial comparing novaloc attachments to locators for single-implant mandibular overdentures in edentate elders. participants will be followed for three months with each attachment type; patient-based, clinical and economic outcomes will be gathered. a sample of 26 participants is estimated to be required to detect clinically relevant differences in terms of the primary outcome (patient ratings of general satisfaction). participants will choose which attachment they wish to keep, then be interviewed about their experiences and preferences with a single implant prosthesis and with the 2 attachments. data from the quantitative and qualitative assessments will be integrated through a mixed-methods explanatory strategy. a last quantitative assessment will take place after 12 months with preferred attachment; this latter assessment will enable the observation of attachments' long-term wear and maintenance events.


Eligibility criteria:
inclusion criteria: * not have had a tooth extraction within the past six months * request implant stabilization of a mandibular conventional complete denture * have clinically acceptable maxillary and mandibular complete dentures * have adequate bone in the anterior mandible for the placement of a single 3.3 mm wide implant in the midline * be able to maintain adequate oral hygiene and clean dentures; * present no systemic conditions for which minor oral surgery would be counter-indicated * have an adequate understanding of written and spoken english or french; * be capable of giving written informed consent exclusion criteria: * severe/serious illness that requires frequent hospitalization * impaired cognitive function * unable to return for evaluations/study recalls * have a history of radiation therapy to the orofacial region * have specific conditions that may jeopardize the treatment, such as alcoholism or smoking (\>10 cigarettes/day) * have acute or chronic symptoms of parafunctional or temporomandibular disorders * previous dental implant treatment following radiographic exam, investigators will exclude volunteers with bony pathologic lesions, less than 11 mm of minimum vertical mandibular bone height in the midline or width for planned implants, evident endosseous vascular structures or mandibular ridges with remaining alveolar sockets

Keywords: aged patients cost estimates complete denture dental economics dental implants dental prosthesis, implant-supported denture retention minimally invasive surgical procedures oral health-related quality of life overdenture patient acceptance of health care quality of healthcare quality of life patient satisfaction single implant overdenture
tailored hydration based on bioimpedance analysis for prevention of contrast induced acute kidney injury

Conditions: Acute Kidney Injury

Summary: the aim of this study was to evaluate, in patients with "normal fluid status" assessed by the bio-impedance analysis, whether two different protocol of iv isotonic saline infusion are associated with different volume expansion and differing risks for contrast induced acute kidney injury in patients undergoing coronary angiographic procedure.

iodinated contrast media are a well-recognized cause of iatrogenic acute kidney injury in patients undergoing imaging diagnostic or therapeutic procedures (contrast-induced acute kidney injury, ci-aki). extracellular volume expansion at the time of contrast media administration may represent important protective strategies that play a major role in the prevention ci-aki. bio-impedance analysis is an inexpensive, rapid, and accurate tool for evaluating a patient's hydration status, and can be performed at the bedside within minutes \[maioli, journal of american college cardiology 1014;63:1387-94\]. in this study we defined patients with "lower fluid status" with high risk of ci-aki (male with resistance/ height ratio \> 315 ohm/meter and female \> 380 ohm/meter). bio-impedance analysis iva may represent the optimal tool to monitor the adequacy of volume expansion and protective strategy delivery. infusing a standardized amount of fluid before the procedure may not result in the same effects in all patients. moreover, standardized fluid infusion for 24 hours in patients that present with "normal fluid status" assessed by the bioimpedance analysis, can represent a too expensive preventive option both in terms of care and discomfort for the patient. in this study we analyze the possibility of a non-inferiority preventive protocol that involves a lower infusion of saline solution with a shorter administration time.

Eligibility criteria:
inclusion criteria: * consecutive patients admitted in cardiology unit for coronary or peripheral angiography with "normal fluid status" assessed on the basis bio-impedance analysis (male with resistance/height ratio \< 315 ohm/meter and female \< 380 ohm/meter) exclusion criteria: * contrast medium administration within the 10 days * end stage renal failure requiring dialysis * no ability to evaluation the state of hydration with bio impedance * refused to give informed consent

Keywords: contrast-induced acute kidney injury contrast-induced nephropathy contrast-associated acute kidney injury contrast media angiography coronary percutaneous intervention
epinephrine inhalation aerosol usp: for evaluation of efficacy and safety in asthma patients

Conditions: Asthma

Summary: this clinical study evaluates the 12-week efficacy and safety of epinephrine hfa inhalation aerosol hfa the proposed hfa formulation of metered dose inhaler (mdi) of epinephrine, in comparison to a placebo-hfa control mdi and the currently marketed primatene® mist (epinephrine cfc inhaler), in adolescent and adult subjects with asthma.


Eligibility criteria:
inclusion criteria: * patients with documented asthma, requiring inhaled epinephrine or beta 2-agonist treatment. * no significant changes in asthma therapy and no asthma-related hospitalization or emergency visits, within 4 weeks prior to screening * can tolerate withholding treatment with inhaled bronchodilators and other allowed medications for the minimum washout period. * demonstrating a screening baseline fev1 that is 50 - 90% of predicted normal value. * demonstrating at least a 12% airway reversibility. * demonstrating satisfactory techniques in the use of metered-dose inhaler and a hand held peak expiratory flow meter. * female patients of child-bearing potential must be non-pregnant and non-lactating at screening and throughout the study, and must use an acceptable method of contraception during the study. exclusion criteria: * a smoking history of 10-pack years, or having smoked within 12 months of screening. * any current or past medical conditions that, per investigator discretion, might significantly affect responses to the study drugs, other than asthma. * concurrent clinically significant diseases. * known intolerance or hypersensitivity to any component of the study drugs. * recent infection of the respiratory tract, before screening. * use of prohibited medications. * having been on other investigational drug/device studies in the last 30 days prior to screening. * known or highly suspected substance abuse.

Keywords: asthma bronchial asthma shortness of breath
cisplatin + rt for triple negative breast cancer

Conditions: Breast Cancer

Summary: this is a phase i dose escalation study of cisplatin and concurrent radiation in patients with er negative, pr negative and her2 negative breast cancer who have undergone breast-conserving surgery or mastectomy. primary objective: to assess the safety, tolerability, and maximum tolerated dose (mtd) of cisplatin when given concurrently with radiation therapy for participants with stage ii or iii breast cancer who have undergone breast conserving surgery or mastectomy

this is a phase i dose escalation study of cisplatin and radiation to determine the toxicity of this combined treatment and establish an mtd.

Eligibility criteria:
inclusion criteria: * primary tumor is triple negative breast cancer * breast-conserving surgery or mastectomy with surgical excision of all gross disease with negative surgical margins * pathologic or clinical stage ii or iii disease * at least 3 week interval from last chemotherapy administration/breast surgery to radiation (no more than 8 weeks) exclusion criteria: * pregnant or breastfeeding * prior radiation to breast or ipsilateral regional nodes * ongoing therapy with other investigational agents * hormonal therapy * significant co-morbidity * pathologic complete response following preoperative chemotherapy * biopsy proven metastatic disease

Keywords: triple negative stage ii stage iii
catgut embedding in acupoints on treating persistent atrial fibrillation after catheter ablation

Conditions: Persistent Atrial Fibrillation

Summary: this is a multi-center, 2-arm, assessor and statistician blinded, pilot randomized controlled trial, to evaluate the effect of catgut embedding in acupoints of neiguan and zusanli in reducing early recurrence and improving long-term prognosis in patients with persistent af after ca..

this multi-center, 2-arm, assessor and statistician blinded, pilot randomized controlled trial will be conducted at two centers in china: shanghai chest hospital; the second affiliated hospital of shandong university of traditional chinese medicine. patients with persistent atrial fibrillation after catheter ablation are 1:1 randomized into group a (amiodarone hydrochloride tablet + acupoint catgut embedding), group b (amiodarone hydrochloride tablet). ecg, inflammatory cytokines,afeqt scale and other indicators are analyzed the effect of catgut embedding in acupoints of neiguan and zusanli in reducing early recurrence and improving long-term prognosis in patients with persistent af after ca.

Eligibility criteria:
inclusion criteria: * 1. age between 18 and 80 years old; 2. persistent af（lasting no more than 3 years）after catheter ablation; 3. no acupuncture treatment within the previous 6 months. exclusion criteria: * 1. a history of allergy to acupuncture or amiodarone; 2. severe heart failure (new york heart association（nyha）class iii or iv); 3. echocardiographic parameters: left ventricular ejection fraction \ 5.0cm; 4. severe lung, liver, kidney disease or other serious primary diseases; 5. skin allergy to ecg monitoring electrode patch. 6. the estimated life expectancy of \< 1 year.

Keywords: persistent atrial fibrillation after catheter ablation catgut embedding in acupoints
genetic factors affecting the severity of beta thalassemia

Conditions: Beta Thalassemia

Summary: patients with genetic diseases can have widely differing severities. we are looking for genetic factors which influence the severity of beta thalassemia.

the understanding of the phenotypic variability of genetically homogeneous disorders represents a major challenge. in beta thalassemia, the beta globin gene is affected by a variety of mutations. the group of patients to be analyzed here is homozygous for a splice site mutation that is common in the middle east. in contrast to this genetic homogeneity, the spectrum of the clinical phenotype ranges from mild anemia to most severe, transfusion dependent anemia. we will use a genetic linkage approach to identify modifying factors and by analyzing the efficiency of an mrna surveillance mechanism that is referred to as nonsense-mediated decay and represents a candidate genetic modifier of beta thalassemia and other genetic disorders.

Eligibility criteria:
inclusion criteria: * identification of homozygous ivs1 nt 6 beta thalassemia mutation
postoperative pain protocol limiting narcotics for laparoscopic hand-assisted donor nephrectomy

Conditions: Narcotic Use; Renal Transplant Donor of Left Kidney

Summary: kidney donors represent healthy patients and their anticipated postoperative course should be uncomplicated and brief. this study looks to optimize the perioperative pain regimen of laparoscopic donor nephrectomy patients by minimizing or eliminating narcotics from the immediate post-operative period. current postoperative standard of care after donor nephrectomy require narcotic analgesics. while narcotics are potent pain medications, they are often associated with complications including nausea, vomiting and dysfunction of the gastrointestinal tract causing prolonged complications. the investigators seek to evaluate a peri-operative pain regimen limiting the usage of narcotics. this incorporates a perioperative analgesic course utilizing combination of an intravenous non-steroidal anti-inflammatory drug (nsaid), intravenous acetaminophen, and intravenous ketamine. all three have been demonstrated to be effective for the control of perioperative pain while decreasing narcotics use. prior to surgery, participants will be consented and randomly assigned to receive the standard of care perioperative pain management using intravenous narcotics as a patient-controlled analgesia (pca) by itself plus placebo or along with the new protocol. the study will demonstrate it the new protocol will limit or eliminate the need for narcotics as a patient-controlled dose during the postoperative period. upon discharge from the hospital, patients will be followed in clinic and via home questionnaires annually for 5 years to evaluate satisfaction, renal function and quality of life.


Eligibility criteria:
inclusion criteria: * all individuals undergoing laparoscopic donor nephrectomies at stony brook hospital exclusion criteria: * patients excluded as a potential kidney donor or surgical candidate (renal failure, cancer, uncontrolled hypertension or diabetes, cognitively impaired adults, children, history of stroke, complicated coronary history or pregnant) * patients with a history of chronic pain or chronic pain medication use * patients who are undergoing open nephrectomies * allergy to nsaid or acetaminophen * hepatic disease or elevated transaminases * peptic ulcer disease * probenecid use * history of traumatic brain injury * contraindications of ketamine use (recent head trauma, open eye injury or glaucoma)
pain predict genetics

Conditions: Chronic Pain; Acute Pain

Summary: pain is the most frequent cause of suffering and disability in society. despite considerable involvement of genetic factors in pain sensation and sensitivity, the individual genes involved remain largely unidentified. in this project the investigators will follow patients undergoing elective major surgery for the development of acute and chronic pain. the investigators will search for clinical as well as genetic factors that can predict the development of pain. these can serve as biomarkers to predict acute and chronic pain development and progression in individual patients and help early individual treatment adaptation.

pain is the most frequent cause of suffering and disability in society. chronic pain seriously impairs quality of life of millions of people worldwide. 10-50% of surgical patients report chronic pain after surgery; up to 10% report severe pain. thus, chronic pain is a significant medical and financial burden to society. despite considerable involvement of genetic factors in pain sensation and sensitivity, individual genes involved remain largely unidentified. knowledge of genetic factors, their phenotypic expression in pain processing, and their link to neuronal correlates can improve understanding of pain aetiology and processes involved in pain perception and chronification. also, they can serve as biomarkers to predict chronic pain development and progression in patients and help early individual treatment adaptation. in this study the investigators will establish a prospective database and biobank of patients undergoing elective major surgery. using data from the database and biobank, the investigators will identify genetic factors contributing to development of acute and chronic pain after surgery. over a period of 10 years the investigators will prospectively include up to 10,000 patients visiting the hospital for elective major surgery. data defining participants demographics, medical history and questionnaire data will be collected and stored in dedicated databases. additional details (surgery and perioperative management, pain processing phenotypes and surgical and pain outcomes) will be stored.

Eligibility criteria:
inclusion criteria: patients: * ages 18 - 80 years, consenting, planned surgery, able to understand and answer questionnaires. exclusion criteria: * non-consent, inability to give consent, unplanned and emergency surgery.

Keywords: clinical predictors genetic factors
study to investigate safety, tolerability and pharmacokinetics of a single ascending dose of azd1704

Conditions: Pain

Summary: the primary aim for this study is to investigate the safety and tolerability of the azd1704, first time in man.


Eligibility criteria:
inclusion criteria: * healthy volunteers, man or woman of non child-bearing potential * provision of signed informed consent. exclusion criteria: * history of somatic disease/condition that may interfere with the objectives ot the study, as judged by the investigator. history of seizures, with the exception of single occasions fever induced seizures in childhood. * history of previous or ongoing psychiatric disease/condition including psychosis, affective disorder, anxiety disorder, borderline state and personality disorder according to the criteria in the dsm of mental disorder, 4th edition * history of use of antipsychotic, antidepressant or anxiolytic drugs for the treatment of psychiatric disease or symptoms, prescribed as well as non-prescribed use.

Keywords: safety tolerability
improving pain management in nursing homes: a research project to enhance care practices

Conditions: Pain Management; Nursing Homes; Elderly; Pain; Health Care Quality, Access, and Evaluation; Patient-Centered Care

Summary: this study aims to improve the way pain is managed in nursing homes. it focuses on training staff, creating better systems to track pain, and involving residents and their families in decision-making. the goal is to provide better, more personalized care for residents, making sure their pain is properly managed and that the staff is well-equipped to support them.


Eligibility criteria:
inclusion criteria for residents: * aged 60 years or older * living in the nursing home (ehpad) for at least 3 months * presence of chronic or acute pain requiring regular management * willing to participate in a semi-structured interview * provided informed and signed consent to participate in the study for family members or close relatives: * family member or close relative who visits the resident regularly * actively involved in the resident's care or support * willing to participate in a semi-structured interview * provided informed consent to participate in the study for healthcare professionals: * registered nurses (rn), nursing assistants (na), or support staff (avs) involved in professional practice analysis groups * nurse managers, department heads, psychologists of the nursing home, or the hospital's quality engineer participating in semi-structured interviews * voluntary participation with informed and signed consent * available to participate in all stages of the project exclusion criteria for residents: * under 60 years of age * living in the nursing home for less than 3 months * absence of pain requiring regular management * cognitive impairment preventing participation in interviews * refusal or inability to participate in discussion and exchange sessions * unwillingness to take part in a semi-structured interview * inability to provide informed and signed consent * resident in end-of-life care for family members or close relatives: * family member or relative with infrequent contact with the resident * refusal or inability to participate in discussion and exchange sessions * refusal to sign informed consent for participation * unwillingness to take part in a semi-structured interview for healthcare professionals: * refusal or inability to participate in group discussions or semi-structured interviews * refusal to sign informed consent for participation * temporary, freelance, or external professionals not part of the regular care team * professionals mandated or forced to participate in practice analysis groups * unavailable to participate in all stages of the project