Kornimate/medical-research-clean huggingface dataset:
the study of koebner in patients with psoriasis and psoriatic arthritis

Conditions: Psoriasis; Psoriasis; Arthritis (Etiology); Koebner Phenomenon

Summary: psodeep 1 is a descriptive digital interview study where we intend to include at least 900 individuals. individuals with known psoriasis or known psoriatic arthritis will access the digital interview via a qr code distributed via their rheumatology or dermatology department using their smartphones. data on answers results are stored digitally and can be accessed parallel to recruitment. questions focus on following fields (all self reported): background information (age/sex), disease duration, disease course/fluctuation, disease diagnosis as given by md, disease treatment, disease severity, disease classification, disease triggers, screening of psoriatic arthritis (questions derived from pest questionnaire), koebner occurence, variability in koebner over time, deep-koebner occurence and variability in deep-koebner over time.

psodeep1 is a descriptive digital interview study. questions on self reported experience of following fields will be stated: background information, disease duration, disease course/fluctuation, disease diagnosis as given by md, disease treatment, disease severity, disease classification, disease triggers, screening of psoriatic arthritis (questions derived from pest questionnaire), koebner occurence, variability in koebner over time, deep-koebner occurence and variability in deep-koebner over time. questions will be distributed using redcap (research electronic data capture) platform provided by lunds university, university of santiago and copenhagen university (www.project-redcap.org). patients with known psoriasis or psoriatic arthritis will reach the questionnaire using a qr-code on patient's information sheet distributed in clinical settings. in sweden, patients will be recruited at dermatology and rheumatology outpatient clinics in malmö, lund, göteborg, örebro, stockholm (skåne university hospital, karolinska hospital, sahlgrenska hospital, ryhov hospital, örebro, hospital). in chile patients will be recruited at hospital clínico universidad de chile and ciec-pmr centro internacional de estudios clínicos - probity medical research. in denmark, patients will be recruited at gentofte hospital and through leo foundation skin immunology research center (copenhagen university) and the parker institute. study inclusion criteria: physician diagnosed psoriasis, psoriatic arthritis or both. age of 18 years or older. ability to comprehend instructions and read the swedish, spanish or danish language (according to country). having a smartphone with which one can access the study questions using a qr code. study exclusion criteria: having participated in the study already. not having a mobile telephone number (used to identify duplicate answers).

Eligibility criteria:
inclusion criteria: * md diagnosis of psoriasis and/or psoriasis arthritis * age over 18 years * ability to read and understand written questions * having/ability to use smartphone * given consent exclusion criteria: - having participated previously

Keywords: koebner deep-koebner psoriasis arthritis
impact of the olfactory stimulation on the people with mild dementia via the horticultural therapy

Conditions: Dementia

Summary: the aim of this study is to examine the effect of the olfactory stimulation intervention on the people with mild to moderate dementia. we recruit 28 participants who has been diagnosed with mild to moderate dementia from 2 day care centers in taipei. they are randomly assigned to three groups, including the olfactory intervention group, game comparison group, and control group. beside the control group, the participant with two other groups were required to attend twelve weeks intervention (twice a week, thirty minutes for one section). every participants completed the olfactory test, both paper-pencil and computer-based examination for cognition, blood test and psychological measurement before and after the intervention. the results showed that the participant in olfactory intervention group significant improved score in the lotca-g examination, and the aβ1-42 concentration of the blood test significant increase in the control group; furthermore, the olfactory intervention group is lowest concentration among three groups in the tau concentration of the blood test via ancova analysis.


Eligibility criteria:
inclusion criteria: * ages \>50 years with a diagnosis of mild or moderate dementia * being admitted to the day care center and living in the community * being willing to do blood test with a family member's consent. exclusion criteria: * experience in chronic rhinitis or sinusitis, which causes loss of smell; inability to perform the cognitive exam or olfactory test (e.g., having a severe hearing impairment) * inability to attend group activities due to severe emotional or aggressive behaviors
multivisceral radical resection for surgical t4b colorectal cancer: propensity score-matched study comparing the the laparoscopic and open approaches

Conditions: Colorectal Cancer

Summary: this study attempts to compare safety and long-term oncological outcomes between laparoscopic surgery and open surgery in the treatment of clinical t4b colorectal cancer.

laparoscopic surgery is controversial for patients with t4b colorectal cancer who require multivisceral resection. with the expansion of the indications for laparoscopic surgery in recent years, surgeons try to perform laparoscopic multivisceral resection for the treatment of clinical t4b colorectal cancer. in this study, investigators attempted to compare safety and long-term oncological outcomes between laparoscopic surgery and open surgery in the treatment of clinical t4b colorectal cancer. this study was a multicenter retrospective cohort study based on a multicenter database which contained hospitalization. according to the operation method, the patients were divided into laparoscopic multivisceral resection group(patients who underwent laparoscopic surgery or conversion to open surgery) and open multivisceral resection group(patients who underwent open surgery directly). the short-term and long-term result was compared between groups.

Eligibility criteria:
inclusion criteria: 1. the patient was pathologically diagnosed as colorectal adenocarcinoma by endoscopic biopsy before operation. 2. all patients were considered to have tumors invading adjacent organs after preoperative radiographic evaluation. 3. all patients were recommended to undergo radical surgery after preoperative multidisciplinary consultation. exclusion criteria: patients with distant metastasis or recurrent colorectal cancer were excluded.

Keywords: colorectal cancer multivisceral resection laparoscope
intravitreal bevacizumab vs photocoagulation for proliferative diabetic retinopathy

Conditions: Diabetic Retinopathy

Summary: the purpose of the study is to evaluate the safety and efficacy of 2.5 mg of intravitreal bevacizumab in one eye, versus panretinal photocoagulation in the contralateral eye, for the treatment of patients with untreated symmetric proliferative diabetic retinopathy.

the current gold standard for the treatment of proliferative diabetic retinopathy is panretinal photocoagulation. however, it is a treatment that results in significant discomfort to the patient, causes reduction of visual acuity and visual field impairment. intravitreal bevacizumab is a novel treatment that reduces intraocular vegf concentration and therefore inhibits neovascular proliferation, without causing significant disconfort to the patient, nor affecting visual acuity or visual fields (although with other risks associated with intravitreal injection). making a comparison between both treatments in different patients is difficult because there are other variables that influence the progression of the disease (such as glycemic control or renal insufficiency). therefore this study is designed using both treatments in the same patient: intravitreal bevacizumab in one eye, compared to panretinal photocoagulation in the contralateral eye, and evaluating visual acuity, visual fields, fluorescein angiography, optic coherence tomography of the macula, and patient discomfort, in a one-year follow-up.

Eligibility criteria:
inclusion criteria: * symmetric proliferative diabetic retinopathy without high risk characteristics * age 18 years or older * patient consent exclusion criteria: * heart attack or cerebrovascular attack * only eye * retinal detachment * vitreous haemorrhage * previous treatment for diabetic retinopathy * media opacities that preclude visualization of the fundus * pregnancy * inability to understands the implications of the protocol

Keywords: diabetic retinopathy bevacizumab photocoagulation
study of rivaroxaban use and potential adverse outcomes in routine clinical pratice (uk)

Conditions: Venous Thrombosis; Pulmonary Embolism; Atrial Fibrillation; Acute Coronary Syndrome

Summary: this prospective cohort study will provide information about: characteristics of rivaroxaban use in patients who are prescribed rivaroxaban for the first time compared to patients who are prescribed warfarin for the first time, the occurrence of intracranial haemorrhage, gastrointestinal and urogenital bleeding, and the occurrence of non-infective liver disease.


Eligibility criteria:
inclusion criteria: * all male and female patients who have been prescribed for the first time either rivaroxaban or standard of care from the date of market authorization of rivaroxaban to dec 31, 2017 exclusion criteria: - patients who have any record of being prescribed their index drug prior to the enrolment period or who qualify as members of both cohorts on the same day, will be excluded

Keywords: rivaroxaban stroke prevention in atrial fibrillation anticoagulants hematologic agents therapeutic uses observational venous thromboembolism secondary prevention of acute coronary syndrome intracranial hemorrhages gastrointestinal hemorrhage
serum proteomic profiling for the early diagnosis of colorectal cancer

Conditions: Colorectal Neoplasms

Summary: no ideal serum biomarker currently exists for the early diagnosis of colorectal cancer (crc). therefore, it is urgent that accurate and reliable serum biomarkers be identified.

magnetic bead-based fractionation coupled with matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (maldi-tof ms) was used to screen serum samples from crc patients and healthy controls.

Eligibility criteria:
patients with colorectal cancer inclusion criteria * histologically confirmed colorectal cancer * aged 18 years or older * have provided written informed consent exclusion criteria * refusal to participate healthy controls inclusion criteria * no cancer history * aged 18 years or older * have provided written informed consent exclusion criteria * refusal to participate * have first-degree relative with a known history of colorectal cancer

Keywords: proteomics serum peptides colorectal cancer maldi-tof ms
study of safety and efficacy of inc280 and cetuximab, in adult c-met positive mcrc and hnscc patients after progression on cetuximab or panitumumab therapy

Conditions: Squamous Cell Carcinoma of Head and Neck (SCCHN); Metastatic Colorectal Cancer

Summary: this was an open-label, phase ib, multicenter clinical trial to determine the mtd/rde of the orally administered c-met inhibitor inc280 in combination with cetuximab. this combination was to be explored in c-met positive mcrc and hnscc patients whose disease progressed on cetuximab or panitumumab treatment. the dose escalation part was to be guided by a bayesian logistic regression model with overdose control. at mtd/rde, additional mcrc and hnscc patients who progressed on cetuximab or panitumumab treatment were to be enrolled in two expansion groups to further assess the anti-tumor activity and the safety and tolerability of the combination of inc280 and cetuximab. patients were to receive inc280 on a continuous bid dosing regimen and cetuximab every week. a treatment cycle was defined as 28 days with no scheduled break between cycles. the trial was terminated because of difficulties in identifying patients who met the eligibility criteria.


Eligibility criteria:
inclusion criteria: * male or female aged ≥ 18 years * metastatic colorectal cancer or head and neck squamous cell carcinoma * c-met positive (defined by c-met ihc intensity score +2 in ≥ 50% of tumor cells and met gene copy number ≥ 5 by fish or ihc intensity score +3 in ≥ 50% of tumor cells) and k/nras wt status for mcrc patients only * at least one previous line of treatment for the metastatic disease and the last treatment must have included cetuximab or panitumumab. documentation of clinical benefit and subsequent progression on cetuximab or panitumumab as the most recent line of treatment is required for patients in the expansion part * measurable disease as per recist v1.1 * ecog performance status ≤ 2 exclusion criteria: * prior treatment with c-met/hgf inhibitors * history of severe reactions to cetuximab and/or panitumumab (except for g3 rash and g3 hypomagnesaemia) * history of acute or chronic pancreatitis * active bleeding within 4 weeks prior to screening visit * symptomatic brain metastases * feeding tube dependence * not adequate hematologic, renal and hepatic function

Keywords: inc280 c-met inhibitor cetuximab metastatic colorectal cancer head and neck squamous cell carcinoma resistance to cetuximab/panitumumab scchn, cancer oral and nasal cavity paranasal sinuses pharynx larynx parotid glands lympth nodes of neck mucosal lining epithelium colon large intestine rectal cancer
preventive effects of different volumes of high-intensity interval training on risk factors for ms in overweight young women

Conditions: Metabolic Syndrome

Summary: this study investigates the effects of different volumes of high-intensity interval training on risk factors for metabolic syndrome in overweight young women.

the sedentary and inactive female overweight subjects, aged 18 to 30 years, were randomly divided into three groups: high volume high-intensity interval training group (4hiit group), low volume high-intensity interval training group (1hiit group) and control group (con group). human morphological measures, blood pressure, insulin resistance, blood analysis, and cardiorespiratory fitness were measured at baseline and after exercise intervention.

Eligibility criteria:
inclusion criteria: * women aged 18-30 years; * bmi≥24kg/m2, indicating overweight and high risk of metabolic syndrome; * maintaining a stable body weight for the three months prior to the study. exclusion criteria: * regular participation in physical exercise (≥3 times/week, exercise time≥30min/time); * any respiratory, musculoskeletal, or cardiovascular diseases; * medical or other contraindications for exercise; * taking medications that affect metabolism; * smoking and/or drinking habits.

Keywords: high-intensity interval training overweight metabolic syndrome risk factor prevention
rtms feasibility study on adolescent depression stimulation

Conditions: Major Depressive Disorder; Unipolar Depression; Bipolar Depression

Summary: this is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rtms) according to clinical protocol. the aim with this pilotstudy is to investigate the feasibility to perform a trial of low-frequency rtms on treatment-resistant depression in adolescents. the study includes adolescents 13-19 years old, with average to severe depression.

the intervention follows the identical clinical procedure used for adults. initially, the resting motor threshold will be determined by stimulation over the motor cortex, by finding the minimal intensity that produces a motor response in the corresponding distal wrist muscles. the rtms will be delivered with a powermag research pptms stimulator (mag \& more), and a figure-of -eight coil, pmd70-pcool (mag \& more). the intervention is within the intended use of this ce-marked medical device. the research participants will receive 1hz rtms with daily sessions on 20-30 consecutive week days. the magnetic pulses will be applied at 120% of the resting motor threshold with a figure-of-eight coil at a 45 degree angle towards the midline. the 1hz rtms protocol is applied 6 trains of 1-min duration separated by 30-sec inter-train "off" periods over the right dlpfc (f4 site 5 according to the10-20 system). the total duration of one 1 hz rtms session is 8 min 30 s.

Eligibility criteria:
inclusion criteria: * informed consent from parents and legal guardian * age 13-19 years * diagnosis of uni- or bipolar depression verified through a mini international neuropsychiatric interview for children and adolescents (mini-kid) * treatment with at least two ssris at an adequate dose for at least 8 weeks exclusion criteria: * epilepsy or medical history of seizures * conductive ferromagnetic or other magnetic sensitive metals implanted in the head or within 30 cm of the treatment coil * implanted device that is activated or controlled in any way by physiological signals * implanted medication pumps * intracardiac lines (even if removed) * active substance use disorder * treatment with any medication that could lower the threshold for seizures * usage of benzodiazepines both as prescribed drug and illegal use * any condition that seriously increases the risk of non-compliance or loss of follow-up

Keywords: repetitive transcranial magnetic stimulation
dream project community health worker intervention

Conditions: Diabetes Mellitus, Type 2

Summary: the dream (diabetes research, education, and action for minorities) project is a community health worker (chw) intervention to improve diabetic management and control among bangladeshis with diabetes in new york city (nyc).

the dream (diabetes research, education, and action for minorities) project is a community health worker (chw) intervention to improve diabetic management and control among bangladeshis with diabetes in new york city (nyc). for a two-arm, randomized controlled trial (rct), investigators will recruit a sample of 256 participants, all of whom are 1) of bangladeshi descent, 2) residing in nyc, 3) diagnosed with type 2 diabetes mellitus (t2dm) and a recent hemoglobin a1c (hba1c) of ≥ 6.5, and 4) between the ages of 21-85. the treatment group receives a six-month chw-led intervention consisting of five monthly group educational sessions, two one-on-one visits, and follow-up phone calls as needed from a chw. the control group receives an introductory educational session only. primary and secondary outcomes include clinical and behavioral measures, such as hba1c and weight change, access to and utilization of care (i.e. appointment keeping and use of specialty care), and knowledge and practice of physical activity and healthful eating. additionally, information regarding chw characteristics, the processes and mechanisms for influencing healthful behavior change, and fidelity of the intervention are collected. outcomes are measured at baseline, 3-months, 6-months for both groups, and at 12-months for the treatment group.

Eligibility criteria:
inclusion criteria: * confirmed clinical diagnosis of t2dm with a hemoglobin a1c (hba1c) of ≥ 6.5%; and * male or female between the ages of 21-85 years old; and * willingness to be randomized to either treatment or control groups. exclusion criteria: * is or was on renal dialysis; * experiencing an acute or terminal illness or serious mental illness; * had a history of recent coronary event within the last 3 months of recruitment; * is pregnant at the time of recruitment; * experienced other severe medical conditions that might preclude participation; * has poor short-term prognosis (expected death in \<2 years); or * is participating in another research study.
akkermansia muciniphila akk11 impact on obesity and metabolic health

Conditions: Obesity

Summary: this is a randomized, double-blinded, placebo-controlled study to evaluate the efficacy and safety of akkermansia muciniphila akk11 in adult obesity.


Eligibility criteria:
inclusion criteria: 1. male or female, aged 18-50 years 2. for healthy subjects: must have a bmi between 18.5 and 24.9 kg/m2 and normal lipid profile (cholesterol total \<200 mg/dl; ldl-c \<100 mg/dl; hdl-c ≥ 40 mg/dl; and triglyceride \< 150 mg/dl) 3. for obese subjects: must have a bmi ≥ 30 kg/m2, weight stable for at least 3 months (± 2 kg) 4. subjects must be either of non-childbearing potential, or if of childbearing potential, must be abstinent or have practiced adequate contraception for the entire study 5. subjects who have not smoked in the past 1 month prior to screening 6. subjects or subject's legally acceptable representatives have the ability to comply with the trial protocol 7. signed informed consent from the subject or subject's legally acceptable representatives (must be obtained before any study-related activities) - exclusion criteria: 1. male or female, aged 18-50 years 2. for healthy subjects: must have a bmi between 18.5 and 24.9 kg/m2 and normal lipid profile (cholesterol total \<200 mg/dl; ldl-c \<100 mg/dl; hdl-c ≥ 40 mg/dl; and triglyceride \< 150 mg/dl) 3. for obese subjects: must have a bmi ≥ 30 kg/m2, weight stable for at least 3 months (± 2 kg) 4. subjects must be either of non-childbearing potential, or if of childbearing potential, must be abstinent or have practiced adequate contraception for the entire study 5. subjects who have not smoked in the past 1 month prior to screening 6. subjects or subject's legally acceptable representatives have the ability to comply with the trial protocol 7. signed informed consent from the subject or subject's legally acceptable representatives (must be obtained before any study-related activities) -
impact of incision size and architecture on wound stability and astigmatism in cataract surgery: an exploratory study

Conditions: Cataract

Summary: one of the most recent advances in cataract surgery is microincisional phacoemulsification (mics). through small incisions of 2.0 mm and less the lens material is emulsified either bimanually or with a thin single coaxial hand-piece. the possible advantages are lower induced corneal astigmatism1, 2, possibly a lower incidence of infection due to higher resistance of the wound to deformation3 and a lower risk of complications such as iris prolapse during surgery in patients at risk such as with intraoperative floppy iris syndrome (ifis). additional factors that have to be taken into account are the construction and the position of the incision and the influence of the extraocular force on the wound morphology.4 another effect that may influence the wound architecture is stromal hydration at the end of surgery.5 wound architecture has recently been assessed6-9 using optical coherence tomography. elkady et al.10 observed the wound architecture in mics cases focusing on corneal thickness and the incision angle. however, none of these studies observed the effect of the wound architecture on post-operative astigmatism. furthermore, all observations in the past have been performed in the post-operative period only and information concerning the wound architecture intra-operatively is missing. a recently launched ce-marked intra-operative oct allows observing the wound architecture intra-operatively. one aim of the study is to assess the influence of the intra-operative wound architecture using a similar grading system as used by calladine and packard (2007)7 on the resistance to deformation of the wound and the surgically induced astigmatism in mics and small incision cataract surgery (sics). in a second part of this exploratory study the effect of a hinged incision with a pre-cut should be assessed along the same line


Eligibility criteria:
inclusion criteria: * age-related cataract * age 21 and older * written informed consent prior to recruitment exclusion criteria: * pregnancy (pregnancy test will be taken pre-operatively in women of reproductive age) * any ophthalmic abnormality that could compromise the measurements

Keywords: incision pre-cut wound architecture oct