Kornimate/medical-research-clean huggingface dataset:
proof-of-concept study on dyspnea analysis via gapco2

Conditions: Acute Dyspnea; Dyspnea

Summary: patients presenting to the emergency department with acute dyspnea undergo arterial blood gas measurement and monitoring of transcutaneous capnography using the tcm5 monitor. the aim of this study is to determine whether gapco2, the difference between transcutaneous and arterial pco2 (paco2 - ptcco2), is correlated with the congestive or non-congestive origin of dyspnea.

upon arrival at the emergency department, patients are placed in the vital emergency reception area for monitoring. an emergency physician will review the selection criteria and offer the patient participation. the information sheet will be provided to the patient along with a copy of the non-opposition form in case of patient agreement. before the introduction of any treatment, a tc 92 sensor is placed on the earlobe (or on the forehead if the earlobe is inaccessible), connected to a radiometer tcm5 monitor, measuring spo2 (massimo technology), perfusion index, and transcutaneous capnography (ptcco2). after a 5-minute equilibration period, measurements were taken throughout the duration of patient management. standard diagnostic and therapeutic management will be provided according to the attending physician's prescription. the attending physician won't consider ptcco2 (nor gapco2) measurements in patient management. at the time of data analysis, an adjudication committee comprising 2 emergency physicians from the inclusion service but not involved in patient care will review the complete medical records of patients to determine whether dyspnea was of congestive or non-congestive origin.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * patient presenting with acute dyspnea defined by a sensation of respiratory discomfort with at least one of the following criteria: rr ≥ 22 and/or spo2 \< 95% * arterial blood gas sampling performed as part of care * inclusion less than 1 hour after arrival time to the emergency department * non-opposition to participation in the study exclusion criteria: * temperature greater than or equal to 37.5°c * patient who has already received a diuretic or vasodilator treatment in the emergency department or by a prehospital medical team * systolic blood pressure less than or equal to 100 mmhg and/or signs of peripheral hypoperfusion * inability to express refusal to participate in the study

Keywords: acute dyspnea emergency department dyspnea congestion proof-of-concept study gapco2
hepatitis c: grading and staging by mr

Conditions: Hepatitis

Summary: to compare mr imaging findings with biopsy for grading and staging early hepatitis c.


Eligibility criteria:
referral only

Keywords: hepatitis c
effect tunnel in oral medicine

Conditions: Psychological

Summary: evaluate whether there are differences in knowledge between practitioners and students regarding the tunnel effect, to validate the benefit of teaching it in oral medicine. main objective: to evaluate the state of knowledge relating to the tunnel effect concerning the performance of a surgical procedure, of a cohort of odontologists of different professional levels. secondary objectives: evaluate the nature of the means they propose in order to counter the effects of this cognitive bias.


Eligibility criteria:
inclusion criteria: - externs in the 6th year, interns and teachers working within the riquier institute of oral medicine at nice university hospital, and private dental surgeons. exclusion criteria: - dental student under 6th year

Keywords: tunnel effect
to explore the optimal dose of alfentanil for skull pin fixation in intracranial surgery

Conditions: Procedural Pain

Summary: forty patients were enrolled, and all patients used total intravenous anesthesia (alfentanil-propofol based tiva) as anesthesia induction and maintenance. according to our experience, patients who underwent intracranial surgery for skull pin fixation used alfentanil 100 ng/ml, while the hemodynamics is relatively stable. therefore, when this plan is implemented, the patient needs to be under the same depth of anesthesia (monitored by eeg, maintaining a value of 40-60), first start with alfentanil 100 ng/ml, and use the up and down method as adjust 25 ng/ml of concentration of alfentanil each time. an spi higher than 80 and hyperdynamics (the increased hr and mbp up 20% of baseline or hr\>100bpm and abp\>180/100mmhg) indicates insufficient analgesia, therefore increase it by 25 ng/ml at the next patient; an spi lower than 80 and stable hemodynamics (the changes of hr and mbp within 20% of baseline or hr\<50bpm and abp\<90/50mmhg) indicates that analgesia is acceptable, and the next patient will decrease it by 25 ng/ml during skull pin fixation. if the analgesia is inadequate, increase alfentanil concentration will be prescribed. on the other hand, if analgesia is adequate, however hyperdynamics was noted, beta blocker or calcium channel blocker will be prescribed. if hypotension (abp\<90/50 mmhg) or bradycardia (hr\<50 bpm) occur, we first stop alfentanil infusion and treated with ephedrine or atropine, respectively. data collection: hr, mbp, spi, bis, systolic pressure variation (spv), pulse pressure variation (ppv) , concentrations of propofol and alfentanil before 2 mins, during, 5, and 15 mins of skull pin fixation were recorded and analyzed.


Eligibility criteria:
inclusion criteria: * must be at least 18 years old and less than 80 years old * with anesthesia risk grade below grade three (including grade three) (asa i\~iii) * patients who are expected to undergo intracranial surgery for skull pin fixation exclusion criteria: * those with anesthesia risk classification asa class iv or higher * those who are allergic to alfentanil or propofol drugs * emergency patients

Keywords: alfentanil pain surgical pleth index
intervention study to evaluate a probiotic in mild to moderate psoriasis patients

Conditions: Psoriasis

Summary: this study evaluates the efficiency of a probiotic as a coadjuvant in the conventional treatment of mild to moderate plaque psoriasis. half of the patients will receive the probiotic per os, while the other half will receive a placebo; all patients will continue with their regular psoriasis treatment.

the aim of this study is to evaluate the efficiency of a probiotic in capsules as a coadjuvant in the conventional treatment of mild to moderate plaque psoriasis. the efficiency is measured as the reduction in the pasi score in the patients (18 to 70 years old) included in the study, with a mild to moderate plaque psoriasis treated exclusively with topic treatment in the moment of being included in the study. apart from the pasi score reduction from the first visit to the end of the study, the ability to reduce the improvement time in those patients will be evaluated as well. additionally, the following markers of systemic inflammation are also compared between both active and placebo branches: tumor necrosis factor, interferon-gamma, interleukines 1b, 12, 16 and 23.

Eligibility criteria:
inclusion criteria: * plaque psoriasis diagnosed at least a year before the beginning of the treatment. * mild to moderate psoriasis with a pasi score higher than 6 with no new flare-up in the previous four week to the beginning of the treatment. * patients capable of giving their informed consent to their participation in the study * for women in fertile age, a negative pregnancy test before the beginning of the treatment, and the use of active contraceptive methods is required exclusion criteria: * patients suffering from crohn disease, hepatic cirrhosis, morbid obesity, vih-positive or any other active infection. * the use of any systemic, oral or parenteral psoriasis treatment in the last three months. * the use of any antibiotic, probiotic or/and prebiotic in the last two weeks. * the use of natural product with proved efficiency on health (apart from multivitamin and multimineral products) * any hepatic, renal, endocrine, respiratory, neurologic or cardiovascular disease. * pregnancy and breastfeeding. * patients not being capable of giving their informed consent or not being capable of following the study conditions.

Keywords: mild to moderate probiotic
biomimetic hydroxyapatite in pediatric patients with asthma and/or allergic rhinitis

Conditions: Dental Caries; Periodontal Diseases

Summary: the aim of the study is to compare the incidence of dental caries and the level of demineralization in pediatric patients with asthma and/or allergic rhinitis. patients will conduct professional oral hygiene at the baseline. the following clinical indexes will be assessed: bewe index, plaque index, bleeding score, schiff air index. then, patients will be randomly divided into two groups: * trial group: domiciliary use of biorepair total protection plus + desensitizing enamel-repair shock treatment twice a day * control group: domiciliary use of elmex caries protection twice a day the clinical indexes will be assessed again after 1 month (t1), after 3 (t2) and 6 months (t3).


Eligibility criteria:
inclusion criteria: * pediatric patients aged between 6-14 years * diagnosis of allergic rhinitis and asthma * therapy with salmeterol/fluticasone propionate * diffused enamel demineralizations of deciduous and permanent teeth exclusion criteria: * low cooperation according to grades 3 and 4 of frankl behavioral scale * nonadherence to the study protocol checked by parents * other systemic diseases.

Keywords: dental hygiene
the effect of antioxidants on the immune response and wound healing in critically ill patients

Conditions: Pressure Sores; Intensive Care

Summary: the purpose of this study is to investigate whether the addition of omega-3 and antioxidants to nutritional support in critically ill patients in the intensive care unit influences the immune and anti-inflammatory systems and so improves wound healing.

a prospective randomized study to include 40 consecutive patients admitted to the general intensive care unit. the control group will receive nutritional support composed of a standard formula. the study group will receive nutritional support enriched with fish oil and anti-oxidants. the following variables will be assessed in all patients: demographics, severity of illness, assessment of bed sores. blood tests will also be taken for the following: cd 8, cd 14, cd 18, cd 11a, cd49c, cd 49d. in addition, blood samples will be collected for tnf, il-1b, il-6, il-8, and levels of c-reactive protein. metabolic parameters such as resting energy expenditure, bmi, albumin, prealbumin, levels of zinc, relationship between omega 3 and omega 6. theses test will be performed at time of icu admission, days 7, 14 and 28 after admission. the outcome: improved repair of pressure sores, together with improvement in objective parameters of immunity and inflammation.

Eligibility criteria:
inclusion criteria: * critically ill patients in intensive care unit * grade 2 pressure sores exclusion criteria: * immunosuppression with steroids or other agents * active bleeding * head trauma

Keywords: intensive care critically ill fish oil pressure sores
the walk-copenhagen trial (walk-cph): a mixed methods study

Conditions: Hospitalization; Activity

Summary: the walk-copenhagen project aims at enhancing physical activity during and after hospitalization in older medical patients by an intervention developed in co-operation with key stakeholders

in four phases we will develop (phase 1), fidelity- and feasibility test (phase 2), efficacy test (phase 3) and adoption test the intervention (phase 4). the project will use a combination of qualitative (phase 1-4) and quantitative methods (phase 2-3) and consists of two parallel tracks - walk-intervention and walk-implementation. phase 1 of the study has been completed. through workshops with patients, relatives, health professionals and researchers we have developped an intervention to enhance physical activity. phase 2 will be carried out in october 2018 and january 2019 at copenhagen university hospital hvidovre and in february 2019 at copenhagen university hospital, frederiksberg. the developed intervention will be fidelity tested through daily observations at the wards. also, the intervention will be feasibility tested in a prospective cohort study aiming at qualifying the intervention, testing recruitment strategies, testing patient willingness towards the intervention, testing randomization and blinding procedures and estimating an inclusion rate for phase 3 (randomized controlled trial) to be conducted in 2019. update march 2019: due to a political decision to close down the medical ward at copenhagen university hospital, frederiksberg in the spring of 2019, it was decided to change phase 3 to a cohort study at copenhagen university hospital, hvidovre. this decision was based on the fact that the methodological setup of the study (cluster rct) was unintentionally changed due to the close down of one of the intervention wards. update november 2019: due to changes in characteristics of patients admitted to the intervention ward and thus a very slow inclusion rate in phase 3 (cohort study), it was decided to terminate inclusion of patients. qualitative data will still be collected as anticipated.

Eligibility criteria:
inclusion criteria: * +65 years * acutely admitted to intervention wards * able to walk independently with or without walking aid exclusion criteria: * in isolation * inability to cooperate * not able to speak or understand danish * in treatment for cancer * terminally ill * transferred to intensive care unit or another ward within 24 hours after admission

Keywords: older medical patient mobility hospitalization activity monitoring cross sectoral
confusion in the elderly after colon surgery

Conditions: Confusion; Inflammation; Acute Phase Reaction; Surgery; Delirium

Summary: a study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.

cognitive changes in the elderly are common after surgery. it is not known if minimally invasive or laparoscopic surgery can prevent these changes. a study will be conducted on patients scheduled to have abdominal surgery. the patients will have cognitive evaluations before and after surgery. a small amount of blood, about 2 tablespoons, will be collected no more than 5 times in 6 months. the results will be analyzed to determine if there are changes between those having open surgery versus patients having laparoscopic or minimally invasive surgery, and if these changes coincide with cognitive changes.

Eligibility criteria:
inclusion criteria: * patients over age 65.0 years and in need of elective colon resection for adenocarcinoma exclusion criteria: * inability to complete preoperative cognitive screening * inability to complete study in english since cantab is timed and not validated with interpreters * emergency surgery * depression or psychiatric comorbidity * pre-existing dementia * previous cerebrovascular accident or "stroke" * previous myocardial infarction * cardiac ejection fraction below 55% * propranolol, metoprolol or other betablocker use * digoxin, procainamide, or amiodarone use * calcium channel blocker use * history of vascular surgery or arterial vascular disease * history of alcohol dependence * lovastatin or other hmg-coa reductase inhibitor use * ace inhibitor use * neuroendocrine or catecholamine associated tumors * hypertension * diabetes * benzodiazepine use * dimenhydrinate or other medications to treat motion sickness * metaclopramide use

Keywords: laparoscopy surgery acute phase reaction aged aged 80 and over confusion inflammation delirium
effect of dipeptidyl-4 inhibitors in reducing stroke severity, from hira database

Conditions: Cerebral Infarction; Infarction, Brain; Dipeptidyl-Peptidase IV Inhibitors

Summary: the goal of this observational study is to compare severity and mortality rates of acute cerebral infarction(requiring thrombolysis or endovascular recanalization) depending on the type of oral antidiabetic drug taken before the onset of cerebral infarction. researchers will compare the group that used dpp-4 inhibitors as anti-diabetic drugs before cerebral infarction and the group that did not use them to see the effect of dpp-4 inhibitors in reducing severity of cerebral infarction.

this is a retrospective study to see the effects of reducing the severity of cerebral infarction(requiring thrombolysis or endovascular recanalization) of dpp-4 inhibitors by comparing the survival rate after acute cerebral infarction hospitalization, discharge rate to home, and medical cost. a. severity of cerebral infarction and poor prognosis is mainly associated with hyperglycemia caused by diabetes, which increases the infarction volume and hemorrhagic trasformation. b. however, the effect of loergin blood glucose on reducing the infarction volume and improving prognosis of cerebral infarction has not been proven. c. preclinical studies have demonstrated a anti-stroke effect that reduces the infarction volume using certain anti-diabetic drugs. d. therefore, there is a possibility that certain anti-diabetic drugs may reduce the severity of cerebral infarction as a class effect in addition to the effect of blood sugar control. e. this is particularly likely to exist in the dpp-4 inhibitor family identified through preclinical studies.

Eligibility criteria:
inclusion criteria: * patients with acute cerebral infarction who underwent thrombolysis or endovascular recanalization in korea between 2014 and 2021 * those who have been previously diagnosed with diabetes and are taking oral anti-diabetic drugs * adult (over 19 years of age) * the definition of antidiabetic drug use is defined as a case in which an antidiabetic drug was prescribed for at least 2 months before stroke and the duration of treatment for stroke coincided with the prescribed duration of the drug. exclusion criteria: * patients taking insulin to control diabetes

Keywords: dipeptidyl-peptidase iv inhibitors antidiabetic drug
study on adhesion properties of three different adhesives

Conditions: Healthy

Summary: this clinical investigation is a single centre, double blinded, case control study in healthy adult females. this study will be conducted in private rooms at gentofte hospital (hjerte-medicinsk forskning, post 835, kildegårdsvej 28, 2900 hellerup). the investigation centre will enroll 39 subjects including a 20% drop out within a four (4) months period. the subject will not be enrolled before approval of investigation protocol by the local ethics committee. the subjects need to meet the inclusion and exclusion criteria to be included in this clinical investigation. each volunteer enrolled in the investigation can only participate once in a procedure. the testing period for each subject will be minimum 72 hours. the principal investigator's qualifications will be verified through his/her cv. the principal investigator is required to be a medical doctor with at least one year's experience in using similar medical adhesives (e.g. by being experienced in using electrodes where medical adhesives are included) and at least one year's experience with clinical research. in addition, the investigator must be trained in gcp before the study is initiated. if any subject withdraws from the study, they will not be replaced as drop-out rate is included in the sample size. subjects must show up for two sessions, in the first session six adhesives will be placed below the subjects bra. the adhesives will be removed after minimum 72 hours at the second visit. while wearing the adhesives the subjects must keep the investigational area dry. 24, 48 and 72 hours after placement of the adhesives, the subject is asked to completed a questionnaire. the ecrf must be completed for each subject that has signed the informed consent form (icf) and enrolled into this clinical investigation.


Eligibility criteria:
inclusion criteria: * female healthy volunteers. * age 18 - 40 years old. * willing to attend two scheduled visits * able to assess itch and adherence at 24h, 48h and 72h. * provide written informed consent. exclusion criteria: * non-intact skin barrier (e.g. eczema, rash, cut, scar tissue, wound, etc.). * history of inflammatory skin diseases (e.g. atopic dermatitis or psoriasis). * history of contact allergy * swimming or engaging in sport activities causing sweat during study peri-od. v. use of medication (e.g. corticosteroids) which could affect skin reactions.
a study to evaluate the pharmacokinetic drug interaction after oral concurrent administration of fimasartan and amlodipine in healthy male volunteers

Conditions: Essential Hypertension

Summary: to evaluate the pharmacokinetic drug interaction after oral concurrent administration of fimasartan and amlodipine in healthy male volunteers


Eligibility criteria:
inclusion criteria: * age: 20 - 40 years * sex: male * body weight: greater than 55 kg * written informed consent exclusion criteria: * known allergy to fimasartan and amlodipine * existing cardiac or hematological diseases * existing hepatic and renal diseases * existing gastrointestinal diseases * acute or chronic diseases which could affect drug absorption or metabolism * history of any serious psychological disorder * positive drug or alcohol screening * smokers of 10 or more cigarettes per day 3 month ago * participation in a clinical trial during the last 2 months prior to the start of the study

Keywords: fimasartan drug interaction
the relationship among electroencephalography,skin conductance response,heart rate variability and mental health among smartphone users after receiving texting or calling

Conditions: Smartphone Users, Smartphone Addiction, Anxiety, and Skin Conductance

Summary: the number of smartphone users in taiwan continues to increase exponentially. smartphone addiction tends to not only disrupt the ability of social communication but cause physical and psychological problems as well. this study examined the relationship among skin conductance, electroencephalography, heart rate variability (hrv), social interaction anxiety and smartphone addiction among line apps users, and we also tried to identify associated factors for further interventions.


Eligibility criteria:
inclusion criteria: (a) were older than 20 years of age and (b) used a smartphone with internet and line app. exclusion criteria: the participants were those who (a) had alcoholism or drug dependence; (b) had any pre-existing major mental disorders; (c) had history of brain injury; and (d) had palmar hyperhidrosis.

Keywords: skin conductance anxiety smartphone users smartphone addiction
prevalence of sleep disordered breathing in a lung cancer screening cohort

Conditions: Sleep Apnea Hypopnea Syndrome; COPD; Emphysema; Lung Cancer

Summary: prospective study of sleep disordered breathing in a lung cancer screening cohort.

the proposed study is a prospective single arm study evaluating the prevalence of sleep disordered breathing in a cohort of lung cancer screening patients.

Eligibility criteria:
inclusion criteria: * age 55-75. * \> 30 pack years tobacco exposure. * enrolled in lung cancer screening program. exclusion criteria: * inability or unwillingness to undergo a home sleep study.