Kornimate/medical-research-clean huggingface dataset:
effect of kinesiology taping on head and trunk control in children with duchenne muscular dystrophy

Conditions: Duchenne Muscular Dystrophy

Summary: muscular dystrophy (md) is a group of muscle diseases that results in increasing weakening and breakdown of skeletal muscles over time. the disorders differ in which muscles are primarily affected, the degree of weakness, how fast they worsen, and when symptoms begin. many people will eventually become unable to walk. some types are also associated with problems in other organs. the muscular dystrophy group contains thirty different genetic disorders that are usually classified into nine main categories or types. the signs and symptoms consistent with muscular dystrophy are: progressive muscular wasting, poor balance, scoliosis (curvature of the spine and the back), progressive inability to walk, waddling gait, calf deformation, limited range of movement, respiratory difficulty, cardiomyopathy and muscle spasms this study aimed to assess the efficacy of kinesiology taping on head and trunk control in patients with duchenne muscular dystrophy

duchenne muscular dystrophy (dmd) is the most common muscular dystrophy type in childhood. trunk control is responsible for adaptation during weight transfers, provides and maintains the upright position of the body, organizes postural and correction reactions; and stabilizes the body to perform proximal and distal limb movements, trunk rotations, and making contact between the shoulder and pelvis. in neuromuscular diseases, the trunk is usually ignored both for assessment and treatment as muscle weakness of limbs attracts more attention. therapists usually focus on activities of lower limb and overhead including standing, walking, climbing, and raising arms to maintain independent mobility in rehabilitation sessions. however, the trunk also gradually gets weaker as the child gets older and this may be associated with movement dysfunction of upper and lower limbs. the kinesio taping method is used in the rehabilitation of musculoskeletal disorders, providing either an increase or a decrease in the neural excitation of the muscle, depending on the therapeutic purpose determined after the clinical assessment.

Eligibility criteria:
inclusion criteria: 1. being at the age of 8-12 years 2. being able to cooperate with the instructions of physiotherapist to perform the assessments and procedures. exclusion criteria: 1. having severe contracture at lower extremities 2. having another neurological and/or musculoskeletal disease diagnosis in addition to dmd. c) having a history of any lower extremity injury or orthopedic/neurologic surgery within the past 6 months.
bone effects of teriparatide following alendronate

Conditions: Osteoporosis

Summary: the purpose of this study is to assess the effect of 24 months of treatment with once daily teriparatide injection (recombinant human pth \[1-34\]) 20 micrograms on bone histomorphometry and architecture. patients will include postmenopausal, osteoporotic women who have been treated long term (at least 36 months) with alendronate, as well as postmenopausal, osteoporotic women who have never been treated for osteoporosis.


Eligibility criteria:
inclusion criteria: * diagnosis of osteoporosis: pretreated patients currently osteoporotic or osteopenic. treatment-naive patients currently osteoporotic * pretreated patients will have had at least 36 months of treatment with alendronate na 10 mg/day or 70 mg/week. treatment-naive patients will have no significant osteoporosis treatment in the prior 36 months, as assessed by the investigator exclusion criteria: * history of bone metabolic diseases, paget's disease, renal osteodystrophy, osteomalacia, any secondary causes of osteoporosis, hyperparathyroidism (uncorrected), and intestinal malabsorption. * history of malignant neoplasms in the prior 5 years, with the exception of superficial basal cell carcinoma or squamous cell carcinoma of the skin that has been definitively treated. if malignant neoplasm was ever diagnosed, patient must presently be free of disease.
does peri-operative gabapentin reduce chronic post-thoracotomy pain?

Conditions: Post-thoracotomy Pain

Summary: the primary objective of this study is to determine if gabapentin can decrease or prevent chronic post-thoracotomy pain.

this study is a prospective double blind randomized controlled trial evaluating the peri-operative use of gabapentin in the prevention or modulation of post-thoracotomy hyperalgesia. treatment will consist of a 600 mg dose of gabapentin or placebo given preoperatively the night before surgery, based on a computer generated randomized assignment. the treatment group will continue to be medicated with gabapentin 300 mg twice daily for one month following surgery. those not included in the treatment arm of the study will continue to take a placebo for the same duration. follow-up will consist of a postoperative visit at approximately 48 hours and a one month clinical visit.

Eligibility criteria:
inclusion criteria: * 18 years or older * undergoing non-cardiac thoracic surgeries * patients determined to have impaired decisional capacity with respect to the provision of informed consent or prisoners will not be included in the study. exclusion criteria: * current gabapentin use or current treatment for neuropathic pain. * pregnant or considering becoming pregnant.
rct for the effectiveness of 3 orthodontic retention schemes on post-treatment stability and gingival recession

Conditions: Relapse; Gingival Recession

Summary: the present study aims to assess the effectiveness of three different retention schemes used to maintain tooth position after orthodontic treatment with fixed orthodontic appliances (stability) and to evaluate possible association between retention scheme and gingival recessions on the lingual surfaces of the lower anterior teeth seen for up to 5 years post-treatment. moreover the possible association between primary relapse tendency and long term occlusal stability will be evaluated.

this is a randomized, controlled, single-center, equivalence trial with three parallel groups and an allocation ratio of 1:1:1, that aims to investigate the effectiveness of 3 orthodontic retention schemes on post-treatment mandibular arch stability and gingival recession.

Eligibility criteria:
inclusion criteria: * both sexes * age between 10 and 16 years * at the finishing stage of orthodontic treatment, programmed for debonding * class i to class ii molar relationship before the beginning of orthodontic treatment * non-extraction treatment plan with fixed straight-wire appliances * space deficiencies and irregularity of no more than 6mm in the maxillary/ mandibular arch (irregularity index) exclusion criteria: * no missing teeth, impacted teeth or other dental anomalies * no congenital anomalies/ syndromes

Keywords: relapse irregularity recession retention
topical aprepitant in prurigo patients

Conditions: Pruritus

Summary: topical aprepitant in prurigo patients - an exploratory phase iia trial with topically applied aprepitant in patients with prurigo


Eligibility criteria:
inclusion criteria: * patient with prurigo suffering from chronic pruritus * disease duration \> six month * therapy refractory to at least two previous antipruritic treatments with topical, intralesional or systemic corticosteroids, or other immunosuppressants, antihistamines, antipsychotics, antidepressants, anticonvulsants and/or uv-irradiation * adult male or female patients, aged 18 to 80 years exclusion criteria: * concomitant medications that are primarily metabolized through cytochrome p450 3a4 * applied topical antihistamines, corticosteroids or mast cell stabilizers to the skin less than 3 weeks prior to visit 1 (screening) or during the course of the trial * uv-irradiation during the last 6 weeks prior to visit 1 (screening) * prescribed systemic medications are limited * clinically significant abnormalities in blood analyses * anamnestic excessive use of alcohol or tobacco or drugs * presence of active tumor disease or history of malignancies within five years prior to visit 1 (screening) * known or suspected hypersensitivity to component(s) of investigational products * within the last 30 days or current participation in any other interventional clinical trial * subjects who have received treatment with any non-marketed drug substance (i.e., an agent which has not yet been made available for clinical use following registration) within the last 6 month * previously enrolled/randomised in this clinical trial * in the opinion of the investigator, the subject is unlikely to comply with the clinical study protocol (e.g., alcoholism, drug dependency or psychotic state) * females who are pregnant, of child-bearing potential and wishing to become pregnant during the trial or are breast feeding * females of child-bearing potential with positive pregnancy test * subjects (or their partner) not using an adequate method of contraception (according to national requirements, as applicable)

Keywords: pruritus
effects of physical therapy on low back pain, disc height index, postural stability, disability, gait and function in persons with postero-lateral disc herniation

Conditions: Herniation, Disc; Low Back Pain

Summary: the current study aims to determine if physical therapy is significantly superior in improving postural stability, pain and function and disc height index in persons with discogenic low back pain, as compared to the standardized medical treatment.


Eligibility criteria:
inclusion criteria: * both male and female participants * postero-lateral lumbar disc herniation * aged 18-50 years old * low back pain intensity less than 80/100mm on visual analogue scale or 8/10 on numeric pain rating scale * positive peripheralization and centralization phenomenon exclusion criteria: * individuals with and any musculoskeletal, metabolic, or neurological disorders that may impair gait, postural stability or sensory integrity will be excluded from the study.
impact of exercise in parkinson's disease

Conditions: Parkinson Disease

Summary: the goal of this research is to identify an intervention that will improve cognition and sleep in persons with pd.

persons with parkinson's disease (pd) often experience non-motor symptoms such as cognitive dysfunction and sleep problems. these symptoms can be more disabling than the motor symptoms of pd. medications are often not effective for treating these non-motor symptoms or can have unwanted side effects. non- medication treatments such as exercise are known to improve the motor symptoms of pd, but the effect of exercise on cognition and sleep has not been fully explored. this study investigates the impact of 16 weeks of supervised exercise, 3 times per week, compared to no-exercise over the same duration, on cognition and sleep dysfunction. participants will be evaluated with cognitive tests and sleep studies before and after 16-weeks to determine the impact of this exercise intervention. the goal of this research is to identify an intervention that will improve cognition and sleep in persons with pd.

Eligibility criteria:
inclusion criteria: * a clinical diagnosis of idiopathic pd, based on the presence of bradykinesia as well as rest tremor and/or rigidity; * hoehn and yahr stage 2-3; * age ≥ 45; * on stable medications for at least 4 weeks prior to study entry; * participants must have montreal cognitive assessment (moca) score ≥ 18; * no contraindications to an exercise program, based on the physical activity readiness questionnaire (par-q), resting physical examination, and 12-lead electrocardiogram. exclusion criteria: * features suggestive of atypical parkinsonism (cerebellar signs, supranuclear gaze palsy, prominent autonomic failure, or prominent upper motor neuron signs); * secondary parkinsonism (multiple strokes with stepwise progression of parkinsonism, neuroleptic treatment at time of diagnosis, or multiple head injuries); * inability to walk without a cane or walker; * regular participation in an exercise program in the past 6 months; * presence of deep brain stimulator; and * untreated sleep apnea.

Keywords: exercise
cognitive, behavioral and aging effects of pain medication in alcohol users

Conditions: Mild to Heavy Alcohol Consumption

Summary: the purpose of this study is to examine the relationship between heavy alcohol use, pain, and response to pain medication in older adults.

potential participants complete a phone screen. if still found eligible, the participant comes in for 1 screening visit (3 hours long). cognitive/problem solving tests, computerized tasks, cpt, questionnaires and functional measures are administered along with a screening blood lab. if a participant is eligible, he/she comes back for 1 full study day visit (9-10 hours long). a testing battery (similar to the one done during the screening visit) is completed at baseline and again at three timepoints following medication administration. blood draws, vital signs, and pupil measurements are taken throughout the day. a follow-up phone call is completed within a few days of the full study day visit, during which a questionnaire is given.

Eligibility criteria:
inclusion criteria: * age of 35 years old or above * mild to moderate pain * alcohol consumption * willingness to refrain from taking any sort of pain medication 24 hours prior to study visit as well as refraining from taking sedative-hypnotics, antihistamines, benzodiazepines, sleep aids, nsaids/opioid pain medications, alcohol, marijuana * cigarette smokers must be willing to refrain from smoking during the all day study visit exclusion criteria: * current regular use of an opioid or medications that involve the opioid receptor (naltrexone (vivitrol), buprenorphine (subutex), methadone (dolophine) * abstains from alcohol * unstable angina or chf; cerebral vascular accident or recurrent tias in the prior 6 months, active cancer requiring current treatment, possible or probable dementia or mild cognitive impairment * diagnosis of schizophrenia or schizoaffective disorder, or anxiety disorder requiring regular medication * history of recreational drug use in the past 1 year, excluding marijuana * new or increased dose (within last 6 months) of cns-active medications that may alter neurocognitive and/or psychomotor function: mao inhibitors, neuroleptics, antidepressants, anticonvulsants, benzodiazepines, sleep aids * medications that may alter oxycodone metabolism: st. john's wort, dilantin, tegretol, corticosteroids, rifampin * known hypersensitivity to oxycodone and other opioids; * pregnancy

Keywords: pain elderly aged opioid cognition side-effects alcohol alcohol use disorder (aud) older
prognostic factors and the impact of various management of acute myeloid leukemia in real life condition

Conditions: Acute Myeloid Leukemia

Summary: the treatment of older patients with acute myeloid leukemia that is secondary to previous myelodysplastic syndrome, myeloproliferative neoplasm, or prior cytotoxic exposure remains unsatisfactory. we compared patients treated with intensive chemotherapy or azacitidine within two centres.


Eligibility criteria:
inclusion criteria: * patients with acute myeloid leukemia
using antibiotics wisely - an antimicrobial stewardship program

Conditions: Multi-Drug Resistant Organisms; Late-Onset Sepsis, Neonatal; Antimicrobial Resistance

Summary: there are significant variations in antimicrobial consumption across canadian neonatal intensive care units (nicus). inappropriate and overuse of antibiotics can result in antimicrobial resistance and adverse outcomes among vulnerable neonatal populations. there are limited data on broad-spectrum antimicrobial use, multi-drug resistant organisms (mdro) prevalence, and effective nicu-specific antimicrobial stewardship strategies. the aim of this study is to develop and implement nicu-specific antimicrobial stewardship strategies at both national and individual unit levels to promote optimal antimicrobial use and decrease the incidence of mdros.

purpose: the investigators aim to develop and implement nicu-specific antimicrobial stewardship program (asp) strategies at both national and individual unit levels to promote optimal antimicrobial use and decrease the incidence of multi-drug resistant organisms (mdro) in canada. hypothesis: the investigators expect to find: * significant national variation in broad-spectrum antimicrobial use, which will not be correlated with rates of sepsis. high antimicrobial consumption rates may be associated with limited existing asp resources and increased neonatal morbidity related to inflammatory cascades. * significant national variation in the prevalence of mdros across nicus. * differences in empirical antimicrobial regimens may be associated with mdro prevalence, and the variation in antimicrobial use may explain some variation in neonatal morbidity. study population and sample size: the study population will include very-low-birth-weight (vlbw) infants (i.e., the group of infants neonates with the highest risk of infections within nicus) admitted to participating tertiary nicus in canada.

Eligibility criteria:
inclusion criteria: * very-low-birth-weight infants admitted to participating tertiary nicus in canada. exclusion criteria: * infants with major congenital anomalies

Keywords: antimicrobial stewardship prematurity neonate
clinical practice guidelines for neck and low back pain in outpatient physical therapy

Conditions: Neck Pain; Low Back Pain

Summary: this study will investigate implementation of a process to enhance clinical practice guideline (cpg) adherence to limit unwarranted variability in initial treatment decisions with high potential for providing more effective and efficient physical therapy management for patients with neck and low back pain.

effective implementation of cpgs to augment initial clinical decision making during physical therapy management of patients with spine related musculoskeletal pain will have several important goals: 1) improve patient pain and disability outcomes, 2) limit over utilization of physical therapy services, and 3) increase adherence to limit unwarranted variation in clinical practice. this proposed pilot study proposal will test if a multifaceted intervention strategy for implementation of neck and low back cpg meets these goals and provide necessary data for larger system wide implementation efforts. specific aim 1: determine if physical therapy clinics that receive neck and low back pain (lbp) clinical practice guideline (cpg) training are associated with improved patient outcomes compared to those that have not received training. neck and lbp specific disability and pain intensity will be assessed at intake, on a weekly basis and at discharge (specific aim 1a). secondary patient outcomes will consist of patient satisfaction scores (specific aim 1b). statistical analyses will evaluate for temporal effects of training considering the stepped wedge study design. specific aim 2: determine if multifaceted interventions for cpg implementation positively impacts physical therapist beliefs, attitudes, knowledge and behaviors over time. cpg adherence (by clinicians) will be indirectly assessed using quantitative and qualitative methods consisting of: 1) clinician checklists, 2) clinician questionnaires, 3) quality indicators, and 4) total proportion outcome measure assessments (specific aim 2).

Eligibility criteria:
inclusion criteria: * 18 years of age or older * receiving outpatient physical therapy for a diagnosis covered in previously published cpgs for neck or lbp * able to read and comprehend english language (necessary for completion of self-report e-forms) exclusion criteria: * any diagnosis indicating systemic involvement * widespread chronic pain syndrome * neuropathic pain syndromes * neurological disorders.

Keywords: outpatient physical therapy
troponin t in chronic obstructive pulmonary disease (copd) patients after physical exercise

Conditions: COPD; Myocardial Diseases

Summary: the primary purpose of the study is to investigate if physical exercise is associated with myocardial damage, expressed by elevated troponin t, in patients with copd.

patients with copd will perform a cardiopulmonary exercise test (cpet) on treadmill until exhaustion, 8-12 minutes. venous blood will be drawn before exercise test and 15 minutes, 3 hours and 24 hours after test for analysis of high sensitive cardiac troponin t (hs-ctnt). the investigators will also measure arterial bloodgas, oxygen uptake, carbon dioxide consumption, ventilation, blood pressure, ecg, heart rate and ask for dyspnea-score.

Eligibility criteria:
inclusion criteria: * copd * gold 2-4 * bode-index ≥ 2 * referred by physician to a cpet exclusion criteria: * other serious pulmonary diseases (e.g. cancer, sarcoidosis, restrictive pulmonary diseases) * chronic heart disease with unstable angina or myocardial infarction ≤ 3 months prior to inclusion * percutaneous coronary intervention (pci) * hypertension that is not controlled

Keywords: troponin exercise
prevalence of hypovolemia and heart failure in non-cardiac surgery

Conditions: Hypovolemia; Heart Failure; Diastolic Dysfunction; Systolic Dysfunction; Venous; Return (Anomaly)

Summary: prevalence of biventricular function of the heart and preoperative level of venous return is not known in non-cardiac non-morbid obese population. the aim of the study is to assess the preoperative function of the heart and status of hypovolemia on the day of surgery.

preoperative transthoracic echocardiography (tte) is conducted in 100 individuals. biventricular function (i.e. systolic and diastolic properties), left ventricular filling pressures and level of venous return are assessed by tte. moreover high-sensitive troponine i and nt-probnp, ecg are collected. multiple echocardiographic parameters will be studied for feasibility in terms of preoperative assessment of the heart.

Eligibility criteria:
inclusion criteria: * body mass index ≤ 35 kg/m2, electively scheduled for breast cancer surgery, endocrinologic surgery (thyroid, parathyroid) and general abdominal surgery. exclusion criteria: * not signed consent.

Keywords: heart failure, diastolic dysfunction, venous return left ventricular filling pressures
postoperative bleeding prevention in massive bone tumour resection

Conditions: Blood Loss; Bone Tumour

Summary: massive bone tumour resection is often associated with important postoperative bleeding. this may determine systemic (anaemia), as well as local complications (wound healing, seroma, haematoma). the objective of this study is to determine whether the use of topical tranexamic acid or topical evicel® will reduce the perioperative bleeding comparing it with usual haemostasis.


Eligibility criteria:
inclusion criteria: * 18 years and older * musculoskeletal tumor (primary or metastatic, benign or malignant) located in extremities, shoulder girdle or pelvis. * massive or bloc tumour resection. * patient's consent to participate exclusion criteria: * known allergy to atx * allergy or known hypersensitivity to bovine proteins (aprotinin) * liposarcomas low grade * history of thromboembolic disease or prothrombotic conditions: * cerebral vascular accident * ischemic heart disease * deep and / or superficial vein thrombosis * pulmonary embolism * peripheral arterial vasculopathy * thrombogenic arrhythmias (eg: acxfa) * patients with cardiovascular stents * prothrombotic alterations in coagulation * treatment with contraceptive drugs

Keywords: clinical trial randomized fibrin glue tranexamic acid blood loss