Kornimate/medical-research-clean huggingface dataset:
the effect of calorie deprivation on adipose tissue distribution

Conditions: Healthy

Summary: in this study, we will be studying the effects of acute calorie deprivation (a 10-day fast) on bone marrow fat, other fat stores and bone parameters. we will be measuring changes in bone marrow fat using magnetic resonance spectroscopy and will use mri to measure subcutaneous and visceral fat depots. our hypothesis is that levels of bone marrow fat will increase after an acute fast.


Eligibility criteria:
inclusion criteria: * men and women, ages 21-45 years * 101-130% of ideal body weight as defined by the 1983 metropolitan life insurance height and weight tables * normal thyroid function * regular menses (women) * normal liver transaminases exclusion criteria: * any disease known to affect bone metabolism, including untreated thyroid dysfunction, cushing's syndrome, or renal failure * any medication known to affect bone metabolism -- including systemic steroids or immunosuppressants -- within three months of the study, excluding estrogen and progestins. patients receiving depot medroxyprogesterone (depo-provera) will be excluded from participating for six months after their last injections. bisphosphonates must have been discontinued for at least one year before participation * serum potassium \<3.0 meq/l * pregnant and/or breastfeeding (women) * diabetes mellitus * active substance abuse, including alcohol * contraindications to mri: cardiac pacemaker, metal implants, claustrophobia

Keywords: healthy subjects fasting weight loss
effect of the omentectomy on the hyperglycemia and the resistance to the insulin in patients with morbid obesity

Conditions: Obesity; Diabetes Mellitus Type 2

Summary: to determine if the omentectomy diminishes hyperglycemia and improves the resistance to the insulin in patients with morbid obesity and propensity to develop to diabetes mellitus type 2.

to determine the blood levels of glucose, curve of tolerance to the glucose, hemoglobin glycosylated, insulin, triglyceride, cholesterol, hdl, ldl, leptin and adiponectin in patients with obesity morbid and that will be put under umbilical surgery and cholecystectomy opened. to put under them umbilical surgery or cholecystectomy open with and without omentectomy to compare the blood levels of of glucose, curve of tolerance wing glucose, hemoglobin glycosylated, insulin, triglyceride, cholesterol, hdl, ldl, leptin and adiponectin before and after the procedure

Eligibility criteria:
inclusion criteria: * all the patients with obesity morbid who suffer of hernia umbilical chronic cholecystitis lithiasic non worsened. * patient with age between the 18 to 55 years of age. * both sorts. * patient with index of corporal mass from 30 to 35. * patient with index waist greater or equal hip of 100cm in men and women greater of 88cm. * patient that has a central glucose of 100 to 125mg. * patient that has a tolerance to the glucose of 140 to 200mg. * patient which they have a result of triglyceride in blood of 300 or greater. * patient that has values of lhd below 40 mg/dl. exclusion criteria: * patient that they have i diagnose already established of diabetes mellitus type 2 and in medical treatment. * patient with elevation of hepátic enzymes (more than 50% of the superior limits of normality) and/or creatinin in 1,5 serum \> mg/dl. * patient with diabetic ketoacidosis history. * uso of oral anticoagulants. * positive test of pregnancy (human chorionic gonadotropin ) for women. * recurrent infections and at the time of the study. * umbilical hernia complicated and strangled or worsened chronic cholecystitis.
athlete whey protein sensitivity: prevalence and performance

Conditions: Food Intolerance

Summary: the objective of this study is to identify the prevalence of whey protein sensitivity in uiw athletes and to assess the effectiveness of 4-weeks of whey versus plant-based protein supplementation on athletic performance and recovery, specifically in those with whey sensitivity.

dependent t-tests and repeated measures analysis of variance (anova) will offer comparative analyses between whey and plant protein conditions in subjects with and without whey sensitivity. symptom questionnaires, perceived performance questionnaires, wearable fitness tracking data, and strength test results will be compared across all four conditions (baseline, washout, whey supplementation, and plant supplementation). related variables will be analyzed using glm univariate, multivariate, and repeated measures. the overall multivariate wilks' lambda and greenhouse-geisser univariate p-levels will be reported. differences among groups will be determined using tukey's least significant differences (lsd) post hoc analyses.

Eligibility criteria:
inclusion criteria: * ncaa division i collegiate athletes at the university of the incarnate word * must complete a medical history form * must be cleared by sports medicine staff for intercollegiate athletic participation exclusion criteria: * individuals with a diagnosed food allergy, lactose intolerance, or inflammatory bowel disease (such as chron's, ulcerative colitis, or celiac sprue)
characteristics, treatment patterns and outcomes for patients with surgically resected lung cancers

Conditions: Lung Cancer; Lung Adenocarcinoma; Lung Squamous Cell Carcinoma; Non Small Cell Lung Cancer; Small-cell Lung Cancer

Summary: this study is a multi-center, observational, real-world study for patients with resected lung cancers in china. with the help of a properly designed data processing algorithm and extensively performed data quality assurance, this study aims to harness the potential of real-world big data to (1) describe characteristics and treatment patterns and their evolving trends; (2) discover features associated with overall survival; and (3) address recently-emerging clinical questions.

lung cancer is the leading cause of cancer-related deaths in china. the recent decade witnessed rapid evolving of demographics, pathological features and prognoses of patients with surgically resected lung cancers. the introduction of minimally invasive surgery (mis) concept and techniques, targeted therapy and immunotherapy changed treatment landscape for patients with surgically resected lung cancers. with more early-stage lung cancers discovered due to the application of ct screening, questions focusing on extent of lung resection, lymph node dissection, application of targeted or immune-therapy to early-stage lung cancers are emerging. this study aims to create a cohort of patients with surgically resected lung cancers and an analytic framework to address the aforementioned clinical questions.

Eligibility criteria:
inclusion criteria: * age above 18. * have received surgical resection for lung malignancies. exclusion criteria: * participants whose data are of low quality, poor completeness or poor internal linkage.

Keywords: lung cancer surgery real world
neural correlates of self body-shape recognition in anorexia nervosa mental

Conditions: Anorexia Nervosa

Summary: body image distortion is a key diagnostic feature for anorexia nervosa. patients suffering from anorexia nervosa tend to perceive themselves as fatter than they are. this bias might be at the origin of a reinforcement of anorectic behavior which might alter medical care. the objective of this study is to identify neural correlates of self-recognition in anorexia nervosa. patients are hypothesized to activate the self-recognition network when seeing images of a fatter body shape than their own.

patients suffering from anorexia nervosa and control subjects (matched by age and study level) are recruited in medical care facilities in lille's metropolis. they are asked to identify their body shape when being presented with 3 different stimuli, i.e.real (rbs), estimated (ebs) and neutral body shape (nbs), in a functional magnetic resonance imaging or functional mri (fmri) machine. while answering to this identification paradigm, we hoped to identify modifications in the self body-recognition network.

Eligibility criteria:
inclusion criteria: * providing informed, dated and signed consent (for minors, consent must be signed by both parents) * with medical insurance * with normal vision * only for the an group : diagnosis of anorexia nervosa (an) restrictive for at least one year and with a body masse index (bmi) between 14 and 18 * only for the control group : bmi between 18 and 25 and without any psychiatric disorder exclusion criteria: * pregnant or breast-feeding women * with antecedent or current neurologic disease * with antecedent or current ophthalmologic disease * contraindication for irmf

Keywords: anorexia nervosa functional mri (fmri) self body-shape recognition
combined electroacupuncture and auricular acupuncture for persistent insomnia

Conditions: Insomnia

Summary: this is a randomized controlled trial to evaluate the clinical efficacy of combined electro-acupuncture and auricular acupuncture for persistent iinsomnia in the adult population in hong kong.

combined electro-acupuncture and auricular acupuncture is potential to be an alternative treatment for primary insomnia. the purpose of this study is to evaluate the clinical effectiveness of combined electroacupuncture and auricular acupuncture on persistent insomnia. this is a randomized double-blinded controlled trial. patients will be randomly assigned to the electro-acupuncture group, the electro-acupuncture plus auricular acupuncture group or the waitlist controlled group. patients will be put into groups and then compared.the chance of getting into each group is 3:3:1.

Eligibility criteria:
inclusion criteria: * aged 18 years or above * hong kong residents * ethnic chinese * meet the diagnosis criteria of presistent insomnia for at least 3 months according to current diagnostic and statistical manual of mental disorders (the proposed fifth edition) * insomnia more than 3 nights per week for at least 3 months * willing to give informed consent * able to comply with trial protocol exclusion criteria: * have a hamilton depression rating scale scores above 18 * have sleep apnea or periodic limbs movement disorder detected by overnight polysomnography * have suicidal risk as assessed by the hamilton depression rating scale suicidal risk item * have current major depressive disorder, generalized anxiety disorders or panic disorder, manic or hypomanic episode, substance use disorders except caffeine and nicotine, organic mental disorder, schizophrenia or any other psychotic disorder * receiving psychotropic drugs with dosage changes in the last 4 weeks prior to screening, baseline or during the study * have valvular heart defects or bleeding disorders or were taking anticoagulant drugs * are pregnant, breast-feeding, or woman of childbearing potential not using adequate contraception * have any unstable psychiatric conditions or serious physical illnesses which are judged by the investigator to render unsuitable or unsafe * have infection or abscess close to the site of selected acupoints and in the investigator's opinion inclusion is unsafe * taking chinese herbal medicine or over-the-counter drugs which are intending for insomnia within the last 2 weeks prior to baseline or during the study * any acupuncture or auricular acupuncture treatment during the previous 6 months prior to baseline

Keywords: insomnia acupuncture electroacupuncture aricular acupuncture randomized clinical trial traditional chinese medicine
pd-l1 and braf expression in nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: the prognostic value of programmed death-ligand 1 (pd-l1) and braf expression in nasopharyngeal carcinoma (npc) is not well-defined. in this study the investigators investigated alterations in pd-l1, braf and egfr by using immunohistochemistry analysis in a cohort of consecutively enrolled npc patients.

npc is a common type cancer in macau and southern china. the role of pd-l1 in npc remains controversial. there many reasons behind these inconsistent findings. we used the sp263 antibody with the standard cut off value of 1% and 5%, which is frequently used for lung cancer and other cancer types. we also plan to include over 150 patients, which will be the largest study in npc. this will help us to gain insights in npc.

Eligibility criteria:
inclusion criteria: * above 18 years of age * locally advanced (stage iiib) or metastatic (stage iv) npc * fresh-frozen tissue samples were available were included * after treatment with curative surgery or radiotherapy in macau * with follow up data were available exclusion criteria: • enrolment in studies that prohibit any participation in this observational study

Keywords: nasopharyngeal carcinoma programmed death-ligand 1 prognosis
efficacy and safety study of nv1fgf in patients with severe peripheral artery occlusive disease

Conditions: Peripheral Arterial Disease

Summary: this study is a double-blind study to evaluate the efficacy and safety of nv1fgf, a pcor plasmid constructed by inserting the gene coding for the fgf compared to placebo in patients with severe peripheral arterial occlusive disease, fontaine's stage iv. the efficacy was assessed by the complete healing of at least one ulcer in the treated limb, 25 week post-baseline and secondary by the rate of amputation and death.


Eligibility criteria:
inclusion criteria: * outpatients with severe peripheral artery occlusive disease defined as rutherford's grade iii, category 5 or 6, or fontaine's stage iv. * trophic lesions with no signs of healing (no reduction in ulcer size or depth) for at least 2 weeks prior to first study treatment administration (day 1). * patients with objective evidence of peripheral vascular disease (resting ankle pressure \< 70 mmhg and/or toe pressure \< 50 mmhg, and/or resting ankle-brachial index (abi) \< 0.4 and/or resting toe-brachial index (tbi) \< 0.3 and/or metatarsal pulse volume recording (pvr) flat or barely pulsatile) in the diseased limb on two consecutive examinations performed at least 1 week apart. * demonstration or documentation (historical data not older than 6 months prior to first study treatment administration) of total occlusion of the affected limb of one or more of the iliac, superficial femoral, popliteal and/or one or more infrapopliteal arteries as assessed by angiography. * life expectancy \> 6 months from the first study treatment administration. * poor/not candidates for revascularization (patients suitable for revascularization but with a high risk of failure/ amputation/ or patients not suitable for revascularization). exclusion criteria: * previous or current history of malignant disease. patients who had successful tumor resection or radio-chemotherapy more than 5 years prior to inclusion in the study and no recurrence will be allowed for inclusion. * suspicion of malignant disease (abnormal x ray,positive. stool hemoccult, positive prostate specific antigen , abnormal mammography, papanicolaou smear of class iv or class v characterization. * lower extremity surgery : bypass/angioplasty of the leg to be treated within 2 months prior to the first administration of study treatment (day 1). * active proliferative retinopathy. * buerger's disease

Keywords: gene therapy paod cli
testing the feasibility of computer-based cognitive training in individuals with multiple sclerosis living in the community

Conditions: Multiple Sclerosis

Summary: cognitive impairments are common in multiple sclerosis (ms) diagnosed both at the onset and throughout the disease course. poor cognitive abilities have been associated with poor outcomes such as higher levels of unemployment, poor quality of life, driving difficulties among others. learning and memory are a common cognitive deficit. this computer-based cognitive training is a 10-session treatment proven to be effective in ameliorating learning and memory in individuals with ms across 3 realms of functioning: objective cognitive performance, daily life activities and neuroimaging. despite this strong efficacy, as well as the recent clinical application of this computer-based cognitive training across the world, recent in-person studies have highlighted that transportation to the clinic to complete treatment sessions is a significant obstacle to clinical use of this effective treatment. to address this limitation, the proposed pilot study will test the efficacy of the computer-based cognitive training administered remotely via zoom health in persons with multiple sclerosis.


Eligibility criteria:
inclusion criteria: * english as primary language * diagnosis of multiple sclerosis exclusion criteria: * most recent exacerbation within one month * other neurological history: head injury, stroke, seizures, or any other significant neurological history will not be included in the study * individuals with an active diagnosis of major depressive disorder, schizophrenia, bipolar disorder i or ii will be excluded from the study. * poor visual acuity (corrected vision in worse eye \&lt; 20/60), diplopia, or nystagmus * inability to understand directions and following one, two, and three step commands * intact new learning and memory: only individuals that show impaired performance on a memory test will be included in the study

Keywords: learning, memory, cognitive training
diagnostic biomarkers to correlate molecular changes and inflammatory cascade in the dental pulp.

Conditions: Vital Pulp Therapy

Summary: this study aimed to evaluate the molecular changes that occur within the pulp tissue during inflammation and its correlation with vital pulp therapy with its different treatment modalities (direct pulp capping, partial pulpotomy and complete pulpotomy).

the diagnosis of irreversible pulpitis was based only on the clinical signs and symptoms which does not always match that of the histological changes of the pulp tissues. so, it is more appropriate to diagnose the pulp according to the molecular changes taking place throughout the pulp tissues. different studies have been conducted to study the molecular changes that take place in the inflamed pulp, including a study that was conducted by rechenberg et al in 2014 which states different locations to obtain samples for these molecules. the best of which was the dental pulp blood sample. many studies stated the way to obtain a blood sample from the pulp and how to prepare and test it to evaluate the levels and concentrations of different inflammatory molecules. many studies were also conducted to study the different changes and accurateness of measurement of different molecules. the pulp inflammation occurs in a low compliance environment of dentinal walls. so, during acute inflammatory reaction, vasodilatation occurs along with increased capillary permeability, which leads to increase in the pulp interstitial fluid pressure which creates more pressure on blood vessels and this prevents beneficial blood flow, which decreases the ability of the pulp to defend itself from bacterial attacks causing tissue necrosis. this necrotic tissue is colonized by bacterial tissues. in the literature, one of the novel treatment modalities for irrevesible inflammation of the pulp is partial removal of the inflammed pulp tissue according to clinical sign (bleeding control), the pulp tissue is removed partially until reaching complete coronal pulp removal or complete pulpectomy until hemostasis is obtained after 10 minutes of moist cotton pellet application.so, the normal pulp is preserved. in 2019, ricucci et al conducted a systematic review for treatment of deep carious lesions with pulp exposure. with treatment modalities ranging from direct pulp capping, partial pulpotomy, complete pulpotomy and pulpectomy. based only on clinical signs of normal appearance of the pulp tissue under magnification with dental operating microscope and bleeding control within 10 minutes with a moist cotton pellet.

Eligibility criteria:
inclusion criteria: * positive response to cold testing. * the age range from 15-45 years. * patients of both sex. * has clinical symptoms of pulpitis with normal apical tissues and supported by radiographic evaluation with no periradicular changes. exclusion criteria: * patients over 45 years of age. * patients with clinical symptoms of periradicular inflammation or periradicular radiographic changes. * negative response to cold testing.

Keywords: partial pulpotomy cytokines direct pulp capping
beta-lactams therapeutic drug monitoring in critically ill patients

Conditions: Infectious Disease

Summary: the population of these monocentric and retrospective study includes patients hospitalized in one of the critical care services of nîmes' community hospital. the objective is to determine the key factors that lead to satisfactory beta-lactams serum concentrations in critically ill patients. clinical and biological features, as well as risk scores are collected and recorded into an electronic case report form. the primary outcome is to show the main characteristics related to adequate beta-lactams serum concentrations in critically ill inpatients. secondary outcomes include the key factors related to inadequate beta-lactams serum concentrations in critically ill inpatients, therapeutic drug monitoring (tdm) impact in the achievement of target beta-lactams serum concentration and the correlation between aminoglycosides and beta-lactams serum concentrations. do both antibiotics have similar elimination kinetics ?


Eligibility criteria:
inclusion criteria: * patient aged at least (≥) 18 years of age. * patient (or his representative for patients unable to give their consent) has given his free and informed consent and has signed the consent form. * patient affiliated to the health insurance scheme * patient hospitalized in one of the critical care services of nimes' community hospital with at least one beta-lactam treatment * patient with at least one beta-lactam tdm during his stay exclusion criteria : * patient who did not consent the use of his personal data * patients under maintenance of justice, tutelage or legal guardianship * patient previously included in the study.

Keywords: beta-lactam lcu
sorafenib as neoadjuvant therapy before cytoreductive nephrectomy in patients with metastatic renal cell carcinoma

Conditions: Carcinoma, Renal Cell

Summary: this local, prospective, multicenter, non-interventional study documents observational data on patients under routine treatment of metastatic rcc with nexavar before and after cytoreductive nephrectomy. it's planned to better understand the impact of cytoreductive nephrectomy on nexavar efficacy and possibly to define patients who get the most benefit from nexavar before cytoreductive nephrectomy.


Eligibility criteria:
inclusion criteria: * - male and female patients ≥ 18 years old * patients with untreated metastatic rcc in whom a decision on neoadjuvant treatment with nexavar before cytoreductive nephrectomy and in case of clinical feasibility resumption of treatment with nexavar after nephrectomy has been made at the time of study enrollment * life expectancy of at least 16 weeks * patients should have signed informed consent form exclusion criteria: * diagnosis of any second malignancy within the last 5 years, except for adequately treated basal cell carcinoma, squamous cell skin cancer, or in situ cervical cancer. * all contra-indications according to the russian marketing authorization: * hypersensitivity to sorafenib or to any of the excipients. * pregnancy and breast-feeding. * age less than 18 years.

Keywords: non-interventional nexavar sorafenib carcinoma, renal cell neoadjuvant nephrectomy russian federation