Kornimate/medical-research-clean huggingface dataset:
prognostic correlation between the ratio of the neutrophil ratio to the ratio of cd4+/cd8+ t cells in patients with advanced non-small cell lung cancer nsclc) undergoing immunotherapy combined with chemotherapy

Conditions: NSCLC (Advanced Non-small Cell Lung Cancer)

Summary: evaluate the prognostic correlation between the neutrophil ratio and the ratio of cd4+/cd8+ t cells in patients with advanced non-small cell lung cancer (nsclc) who receive immunotherapy combined with chemotherapy, with the aim of providing references for clinical treatment.

according to the content released in the global cancer statistics report 2022 (global cancer), lung cancer is the leading cause of cancer-related deaths worldwide. traditional treatment methods such as surgery, radiotherapy, and chemotherapy have limitations in their curative effects. immune checkpoint inhibitors (icis) have greatly changed the treatment landscape of non-small cell lung cancer (nsclc). although progress has been made in immunotherapy, the prediction of its efficacy relies on methods such as tumor mutational burden (tmb) and the expression of pd-l1. therefore, finding more effective treatment strategies and prognostic evaluation indicators has become a key task in lung cancer research. relevant studies have delved into the prognostic and predictive values of inflammation-related peripheral blood biomarkers in nsclc patients receiving immunotherapy. the neutrophil-to-lymphocyte ratio (nlr) has emerged as a potential biomarker for cancer prognosis. however, lymphocyte subsets can be influenced by factors such as race, age, medications, gender, stress, physical activity, and lifestyle. in this study, cd4+/cd8+ t cells were selected to eliminate the influence of individual differences, and it is intended to investigate whether there is a prognostic correlation of cd4+/cd8+ t cells in the immunotherapy combined with chemotherapy for patients with advanced nsclc.

Eligibility criteria:
inclusion criteria: * (1)inoperable stage iii or iv nsclc (ajcc 8th edition tnm staging) confirmed by pathological histology or cytology.(2)received first - line immunotherapy (pd - 1/pd - l1 inhibitors) combined with chemotherapy, and driver genes are negative.(3)there is at least one measurable lesion in the lungs on ct imaging (recist 1.1).(4)have complete clinical data.(5)the patient or the authorized family member gives informed consent. exclusion criteria: * (1)have gene mutations such as egfr/alk/ros1 and have not received standardized targeted therapy.(2)have a second primary malignant tumor concurrently.(3)have been infected or used antibiotics within 7 days before blood sampling.(4)have severe abnormalities in the functions of organs such as the heart, liver, lungs, kidneys, and bone marrow.(5)have other autoimmune diseases and endocrine and metabolic diseases concurrently.

Keywords: nsclc lung cancer pulmonary carcinoma
violence against women in patients with alcohol substance addiction training

Conditions: Woman Abuse; Addiction; Violence; Men

Summary: this study was planned as a randomized controlled trial in order to determine the effect of creative drama training for alcohol-substance dependent male patients on their attitudes towards violence against women.

this study was planned as a randomized controlled trial in order to determine the effect of creative drama training for alcohol-substance dependent male patients on their attitudes towards violence against women. the study was planned to be fully experimental. the participants to be included in the study will be selected from men who are followed up with a diagnosis of addiction in a mental health hospital. in the experimental group, male patients will be given violence against women training supported by creative drama five days a day. it will be used as an improved scale-measuring tool for women before and after the training. in the control group, the trainings applied in the service operation will be applied. it will be used as an improved scale-measuring tool for women before and after the training.

Eligibility criteria:
inclusion criteria: * literate, * male inclusion, * have reached the age of 18, * do not have an acute psychotic illness, * patients without symptoms of delirium tremens or intense withdrawal made up the study group of this study. exclusion criteria: * illiterate,woman, * have an acute psychotic illness, * delirium tremens or those with symptoms of intense withdrawal, * patients who did not agree to participate in the study were not included in this study.

Keywords: violence women addiction creative drama
association between renal reserve function and progression of renal function to predict ckd risk in thai elderly

Conditions: Elder; Renal Function Abnormal

Summary: this study investigates renal functional reserve in elderly.

the prevalence of ckd in elder is high as age has been a variable in egfr equation. egfr by calculation always declines in parallel with age. the assumption that a persistent over 3 months of egfr less than 60 ml/min/1.73m2 define ckd with risk of progression and need refer to nephrologist may not necessary true in aging population. we study renal functional reserve in elderly population who risk of ckd progression and esrd is the highest prevalence in human life cycle and explore whether renal functional reserve can be used as ad additional marker of ckd progression in elderly.

Eligibility criteria:
inclusion criteria: * patient age \> 60 years at screening * patient willing to participate in the study and can provide inform consent * patient have residual kidney function ≤ 90 ml/min/1.73m2 by ckd-epi equation exclusion criteria: * patient active smoking * patient have charlson comorbidity index \> ..... * patient active cancer * patient contraindications for blood collection * patients with a history of hypersensitivity to cimetidine or amino acid iv solution

Keywords: renal functional reserve, ckd progression, elderly
knowledge beliefs and expectations of chronic musculoskeletal patients about their physiotherapy program

Conditions: Chronic Musculoskeletal Pain

Summary: the purpose of this study is to investigate the knowledge, beliefs and expectations of patients with chronic musculoskeletal pain about their physiotherapy program and the relationship that they built with physiotherapists.

the main questions of this study are: have patients with chronic pain educated in pain? to what extent physiotherapists use appropriate communication skills and show empathy? what expectations do the patients have of their rehabilitation program?

Eligibility criteria:
inclusion criteria: * patients with chronic musculoskeletal pain more than 3 months and intensity more than 3/10 vas. * greek speaking patients * patients who are following or followed a physiotherapy treatment for their pain exclusion criteria: * none

Keywords: chronic musculoskeletal pain pain education patient expectations communication skills physiotherapy
memantine and postoperative pain

Conditions: Pain

Summary: memantine is associated with improvement in pain relief after surgery.

this prospective, randomized, controlled trial will investigate whether perioperative memantine has a postoperative analgesic effect following radical retropubic prostatectomy (rrp). 100-110 patients scheduled to undergo rrp at duke will be assessed preoperatively for allodynia using von frey filaments, then stratified into two groups based on the presence or absence of allodynia. patients in each group will then be randomized to receive either memantine 20 mg or placebo 30-60 minutes preoperatively, followed on postoperative day 1 with either memantine 10 mg in the morning and 10 mg in the evening for memantine patients, or placebo at the same intervals for placebo patients. data such as morphine consumption, patient satisfaction and pain scores, opioid-related side effects, and the area of hyperalgesia around the surgical incision will be recorded for the initial 48 hours postoperatively, and patient satisfaction with their postoperative analgesia will be assessed after 1 week. at 1, 3, and 6 months postoperatively, patients will be asked about the presence and intensity of any persistent pain related to surgery.

Eligibility criteria:
inclusion criteria: * male * age 18 to 75 years old exclusion criteria: * chronic pain conditions or taking regular analgesics * taking psychotropic medications * parkinson's disease * narrow-angle glaucoma * known gastroduodenal ulcer * history of seizure disorder * renal insufficiency, as defined by serum creatinine greater than 2 mg/dl * liver disease, including liver failure, cirrhosis, or acute hepatitis * significant coronary vascular disease or cardiac conduction system disease, as noted by ecg or history of cardiac symptoms, or cardiac ejection fraction less than 30% * american society of anesthesiologists (asa) score of 4 or higher * allergy to ketorolac or memantine
efficacy of using 50 ml syringe manual thrombectomy catheter in primary pci with heavy thrombus burden

Conditions: STEMI - ST Elevation Myocardial Infarction; Thrombosis Cardiac

Summary: in high thrombus burden subgroup of acute stemi, manual aspiration thrombectomy was associated with reduced cardiovascular death but increased stroke or transient ischemic attack. the role of aspiration thrombectomy is still a matter of active debate. manual aspiration suffers from decreasing aspiration force as the syringe fills with fluid and requires the operator to exchange syringes during the procedure to maintain suction.

acute st-segment elevation myocardial infarction (stemi) poses a major hazard to human life and health due to its high morbidity and deaths. the frequency of stemi is increasing. although dual antiplatelet treatment (dapt) and primary percutaneous coronary intervention (ppci) have enhanced survival in stemi suffers during the last 20 years. complications after myocardial infarction continue to be a major contributor to high mortality and disability. treatment focuses on minimizing infarct size by reopening the occluded artery and restoring myocardial perfusion while ppci is an established treatment option and can reliably re-establish flow, it can also cause distal embolization, resulting in persistent microvascular obstruction and poor myocardial perfusion. poor myocardial perfusion after pci is associated with worse left ventricular functional recovery and increased long-term mortality. by removing thrombotic material, aspiration thrombectomy before pci may reduce the risk of distal embolization and improve myocardial perfusion. a meta-analysis of large randomized trials comparing aspiration thrombectomy and pci alone found that routine manual aspiration thrombectomy did not improve clinical outcomes. however, in the high thrombus burden subgroup, manual aspiration thrombectomy was associated with reduced cardiovascular death but increased stroke or transient ischemic attack. for select cardiac populations, particularly those with high thrombus burden, the role of aspiration thrombectomy is still a matter of active debate. manual aspiration suffers from decreasing aspiration force as the syringe fills with fluid and requires the operator to exchange syringes during the procedure to maintain suction.

Eligibility criteria:
inclusion criteria: * patients with stemi within 12-24 h of symptom onset in native coronary vessel with heavy thrombus burden (thrombolysis in myocardial infarction \[timi\] thrombus grade 4 or 5 on angiography after the guidewire crossed the target lesion) exclusion criteria: * very delayed stemi presentation. * stemi with low thrombus burden. * stemi with cardiogenic shock. * failed recanalization of culprit vessel. * complex coronary anatomy candidates for coronary artery bypass graft.

Keywords: stemi heavy thrombus burden manual thrombectomy 50 ml syringe
the role of referred pain from the retro trochanteric region in patients with knee pain

Conditions: Referred Pain

Summary: the role of referred pain from the retro trochanteric region, in patients with knee pain. defining and quantifying this sub group of knee patients in the investigators list of refered knee patients. evaluating the effect of treatment. a randomized trial.

knee pain is a great problem in the society. besides obvious and known causes, for which there are increasing understanding and ways to treat, there is still a rather large group of patients in which the symptoms are not easily understood and harder to treat. this group is often characterized by having symptoms ranging from months to years, having seen several physicians, gone through several x-rays/mri´s, and various treatment with no help. the investigators find ever more suspicion towards specific mechanisms in the hip region as a source of knee pain. it is well known in pediatric medicine that children with serious disease in the hip often debut with knee pain. this relationship is not so well established in adults. pain in the lower extremity can arise from inflammation or strain of the retro trochanteric muscles, and/or more indirectly if these processes impact the sciatic nerve. the later explanation is commonly known as the piriformis syndrome. professor oddmund johansen has studied this type of pain extensively. in the later years he has found interest in patients with knee pain. these patients will often have pain with deep palpation to the posterior hip region, when tightening the hip rotators with flexion and adduction, and they will often respond with pain relief, within minutes, when local anesthesia is placed on the distal attachment of the hip rotators on the posterior margin of the greater trochanter. afterwards, lasting pain relief can be seen with a specified stretching regiment for these muscles. the investigators will recruit suiting patients from a knee referral list. inclusion will be based on clinical examination and whether they respond to the injection. after inclusion they will be scored with pain and quality of life forms, randomised in two groups, one with a stretching regime and one with conservative and symptomatic treatment. there is interest in defining and quantifying this sub group of knee patients. they will be followed up after 3 months, with a new examination and scoring to evaluate the effect of the intervention. the study will examine how the patients react and comply with the proposed diagnosis and treatment. a cost analysis will also be considered.

Eligibility criteria:
inclusion criteria: * knee pain * failure to understand the pain with more conventional diagnosis * symptoms and retrotrochanteric pain with examination * pain relief with retro trochanteric local anaesthetic injection exclusion criteria: * mental illness * failure to cooperate * not adequate norwegian language skills * other well known disease explaining symptoms

Keywords: knee pain
the power of 24-hour: co-designing intervention components

Conditions: Overweight and Obesity

Summary: most of the existing lifestyle interventions in adults with overweight or obesity focus on one movement behavior in isolation (i.e. moderate to vigorous physical activity (mvpa)). however, recent research suggests to incorporate all movement behaviors performed in one day to explore the possible synergistic health effects of targeting more than one behavior. moreover, more optimal 24-hour movement behavior compositions are related with better cardiometabolic health. literature shows that adults with obesity have less optimal 24-hour compositions (8-9). therefore it would be of interest to discover the needs related to an optimal 24-hour movement behavior intervention for a group of adults with overweight and obesity using co-design to develop an intervention. this study will conduct a concept mapping protocol to explore the needs to of people with overweight and obesity to change their sedentary behavior into more physical activity as well to include the opinion of health care providers (hcp are physiotherapists) on the needs of their patients.


Eligibility criteria:
group health care providers inclusion criteria: * the hcp will consist of physiotherapists and movement on referral coaches (https://www.gezondleven.be/projecten/bewegen-op-verwijzing). hcp are included when working on a healthy lifestyle as well as working with clients struggling with overweight or obesity. group adults with overweight and obesity inclusion criteria: * adults aged 25-64 years * active on the job market for at least 50 percent * bmi ≥25kg/m² exclusion criteria: * - retirement and early retirement * unemployment * working for less than 50 percent * working in night shifts * physical (e.g. amputations, paralysis, recovering from stroke, osteoarthritis), cognitive (e.g. dementia, psychological disorders) and major medical (e.g. chronic respiratory diseases, heart failure, cardiovascular diseases, cancer) conditions that obstruct daily functioning * diabetes diagnosed by a general practitioner * pregnancy * pregnancy \<1 year ago * currently involved in study specific weight loss interventions * post-surgery weight loss interventions * waitlist for weight loss surgery * hospitalized

Keywords: concept mapping physical activity sedentary behavior qualitative research
a study to evaluate the safety and efficacy of nivolumab monotherapy and nivolumab in combination with ipilimumab in pediatric participants with high grade primary central nervous system (cns) malignancies

Conditions: Various Advanced Cancer

Summary: the purpose of this study is to determine the safety and effectiveness of nivolumab alone and in combination with ipilimumab in pediatric patients with high grade primary central nervous system (cns) malignancies.


Eligibility criteria:
inclusion criteria: * must have received standard of care therapy, and there must be no potentially-curative treatment available, in one of the following cohorts: * a newly diagnosed diffuse intrinsic pontine glioma (dipg) that has been treated with radiation therapy (rt) but no chemotherapy * a histologically confirmed recurrent or progressive non-brainstem high grade glioma (hgg) previously treated with surgical resection and rt * a histologically confirmed medulloblastoma that has relapsed or is resistant to at least one line of prior therapy including surgery, rt, and chemotherapy * a histologically confirmed ependymoma that has relapsed or is resistant to at least one line of prior therapy including surgical resection and rt * a histologically-confirmed high grade cns malignancy "other than above" which is recurrent or progressive after at least one line of prior therapy * lansky play score (lps) for ≤ 16 years of age or karnofsky performance scale (kps) for \> 16 years of age assessed within two weeks of enrollment must be \>= 60 * a tumor sample must be available for submission to central laboratory (not required for dipg) exclusion criteria: * an active, known, or suspected autoimmune disease * a concurrent condition requiring systemic treatment with either corticosteroids or other immunosuppressive medications within 14 days of start of study treatment * known history of positive test for human immunodeficiency virus (hiv) or known acquired immunodeficiency syndrome (aids). other protocol defined inclusion/exclusion criteria apply
the pathophysiology of orthostatic hypotension

Conditions: Autonomic Nervous System Diseases; Orthostatic Hypotension; Dopamine Beta-Hydroxylase Deficiency; Orthostatic Intolerance

Summary: the purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system. these patients frequently have had symptoms throughout their life, and their disorder might have a genetic basis. the biochemical, physiological and pharmacological procedures in this study should help us define the problem and perhaps lead to more effective treatment.


Eligibility criteria:
inclusion criteria: * severe orthostatic hypotension and other autonomic symptoms but do not meet criteria for standard diagnosis * non-smokers * drug-free * able to give informed consent * free of pulmonary, renal, hematopoietic, hepatic and cardiac disease exclusion criteria: * medications affecting the autonomic nervous system * any chronic illness * anemia (hct\<30) * women of childbearing age who are pregnant or nursing * smokers

Keywords: autonomic nervous system diseases blood pressure congenital orthostasis catecholamines
efficacy and safety assessment of intracameral injection of t2380 in cataract surgery

Conditions: Cataract

Summary: the purpose of this study is to determine the efficacy and safety assessment of t2380 for mydriasis and anaesthesia in phacoemulsification cataract surgery versus reference group (topical mydriatics and anaesthetic) 2x246 patients.

in order to perform pupil size measurements and ocular discomfort assessments at specific times, the surgical procedure was divided into 5 time periods according to the following time points: t1 (just before first incision), t2 (just before viscoelastic injection), t3 (just before capsulorhexis), t4 (just before intraocular lens injection), and t5 (just before cefuroxime injection).

Eligibility criteria:
inclusion criteria: * signed and dated informed consent * male or female aged from 40 to 88 years old * scheduled to undergo unilateral cataract surgery exclusion criteria: * combined surgery * previous intraocular surgery
silesian registry of out-of-hospital cardiac arrests

Conditions: Out-Of-Hospital Cardiac Arrest

Summary: silesian registry of out-of-hospital cardiac arrests (sil-ohca) which is an initiative of the voivodeship rescue service in katowice in cooperation with the silesian center for heart diseases in zabrze is a prospective, population-based registry of out-of-hospital cardiac arrests (ohca). the main aim of the sil-ohca is to asses the frequency of ohca in the population of upper silesia and analyze prognostic factors for long-term survival in patients with ohca.


Eligibility criteria:
inclusion criteria: * out-of-hospital cardiac arrest treated by emergency medical services of voivodeship rescue service in katowice. exclusion criteria: * none

Keywords: ohca cardiac arrest cardiopulmonary resuscitation
vitamin d and pregnancy: camden study

Conditions: Reproductive Effects; Pregnancy

Summary: vitamin d is present in food either naturally or by fortification and included in nutritional supplements. it is also synthesized photochemically by the skin from ultraviolet b radiation. vitamin d synthesis varies by season and with latitude as well as according to intensity of skin pigmentation. recent research in the united states found lower circulating levels of 25 (oh) d, the primary indicator of vitamin d status, among minority women who were either pregnant or in their reproductive years. the extent to which maternal vitamin d has an influence on the course and outcome of human pregnancy remains to be more completely studied. we propose to use the hplc method to assay cholecaliferol (vitamin d3) and ergocalciferol (vitamin d2) to assess maternal vitamin d status. this will be accomplished by analyzing existing fasting samples and data derived from the 2001-2006 cohort (n=1141) of young, low income minority gravidae from camden, new jersey to determine: 1. the prognostic importance of maternal vitamin d status for birth weight, gestation duration and poor pregnancy outcomes (low birth weight, preterm delivery, fetal growth restriction). 2. the relation of maternal vitamin d status to important complications of pregnancy (gestational diabetes and pre-eclampsia). 3. the relationship of maternal vitamin d status to maternal diet and supplement use, season of year, ethnicity, overweight/obesity, and other maternal characteristics.


Eligibility criteria:
inclusion criteria: positive pregnancy test, informed consent, gestation at entry ≤20 weeks exclusion criteria: women with serious non-obstetric problems including lupus, type 1 or type 2 diabetes, seizure disorders, malignancies, acute or chronic liver or renal diseases, drug or alcohol abuse and psychiatric problems were not eligible for participation.

Keywords: pregnancy minority women preterm delivery fetal growth restriction preeclampsia gestational diabetes vitamin d