Kornimate/medical-research-clean huggingface dataset:
newcastle low back pain intervention study

Conditions: Low Back Pain, Mechanical

Summary: the aim of this study is to investigate if six-weeks of exercise intervention, 3 times per week on the functional re-adaptive exercise device (fred) reduces non-specific mechanical low back pain in adults ages 18-60.

the aim of this study is to investigate whether an six-week fred exercise intervention reduces low back pain (lbp) and improves a range of related outcomes. the objectives of this study are to examine 1. whether fred exercise reduces mechanical lbp ( low back pain); 2. whether fred exercise improves functional and static balance in people with lbp; 3. whether fred exercise has an effect on cross-sectional area (csa) of relevant lumbo-pelvic muscles; 4. whether fred exercise has an effect on tra (transversus abdominis), lm ( lumbar multifidus), lumbar erector spinae, external and internal oblique muscle activity and function in individuals with lbp; 5. whether fred exercise has an effect on tra and internal oblique muscle thickness; 6. the rate of muscle physiology change in response to fred exercise in people with lbp; 7. whether fred exercise affects the analgesic intake, need for intervention and physical activity level of individuals with lbp; 8. whether fred exercise affects wellbeing and every-day function in people with lbp; 9. the rate of change of level of pain, wellbeing and of function (incl. balance) in response to fred exercise in people with lbp.

Eligibility criteria:
inclusion criteria: * mechanical lbp for 8 weeks or longer * score of \< 15 on fabq * age 18-60 * commitment to taking part in the study for its full duration exclusion criteria: * presence of "red flags" - indicative of non-mechanical lbp * score of \> 15 on fabq or other indicators of a likely poor response to a solely physical approach to treatment incl. seeking compensation for lbp * exercise contraindicated as per physical activity readiness questionnaire * inability to exercise safely on the fred * pregnancy * surgery within the previous nine months * difficulty to exercise safely in standing for 30 mins 3x/week * cardio/respiratory disease * neurological disorders * bmi \> 28 where adipose tissue infringes on ultrasound imaging and intramuscular electrode placement

Keywords: lumbo-pelvic muscles rehabilitation exercise low back pain functional re-adaptive exercise device
preoperative inflammatory markers predict postoperative complications after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal colorectal carcinomatosis

Conditions: Peritoneal Carcinomatosis

Summary: a retrospective study of a single-center prospective database of patients who underwent curative crs-hipec for peritoneal carcinomatosis (pc) of colo-rectal cancer (crc), between september 2012 and july 2023 at reims hospital-university was conducted. inclusion criteria were: patients older than 18 years with a performance status ≤ 2, who underwent complete (no macroscopic residual disease) crs-hipec was performed. exclusion criteria were the presence of an infectious disease prior to surgery, crs without hipec, incomplete crs and expressed refusal to participate in the study. during the month prior to surgery, patients underwent a thorough diagnostic workup, including chest and abdominopelvic computed tomography (ct) scans, complete haematological and biochemical tests, and cytobacteriological analysis of urine. blood tests included leukocytes, neutrophils, lymphocytes, platelet count, albumin and crp. within one week before surgery, patients were examined by both the surgeon and the anaesthetist. variables with a normal distribution are presented as mean-sd, while those with a non-normal distribution are presented as median and range. categorical variables are presented as counts and percentages. chi-square or fisher's exact test was used to compare qualitative variables. linear regression analysis was used to assess any association between preoperative inflammatory biomarkers and patient comorbidities and disease characteristics. preoperative levels of inflammatory biomarkers were compared between patients with no postoperative complication (poc) and patients with poc and major poc using the non-parametric mann-whitney u test. optimal cut-off values for significant inflammatory biomarkers were determined using the youden index. receiver operating curves (roc) were calculated to determine the area under the curve (auc). univariable and multivariable analyses including cut-off values of significant biomarkers were performed in a binary logistic regression analysis and expressed as odds ratios (or). all tests were two-tailed and results were considered significant if the p-value was \< 0.05. statistical analyses were performed using r software (version 4.0.5).


Eligibility criteria:
inclusion criteria : * patients older than 18 years * with a performance status ≤ 2, * who underwent complete (no macroscopic residual disease) crs-hipec. exclusion criteria : * the presence of an infectious disease prior to surgery, * crs without hipec, * incomplete crs * expressed refusal to participate in the study
effect of gui-lu-er-xian-jiao-wan on intradialytic hypotension

Conditions: Intradialytic Hypotension

Summary: intradialytic hypotension (idh), a common complication during hemodialysis (hd) could increase patients' morbidity and mortality. previous studies considered that some chinese herbal medicine (chm) plays a complementary role in reducing the frequency of idh. this trial is aimed to investigate the effect of gui-lu-er-xian-jiao-wan (glexjw) in patients with intradialytic hypotension.


Eligibility criteria:
inclusion criteria: * end stage renal disease treated with hemodialysis for ≥3 months * receive a standard thrice-weekly hemodialysis schedule * more than 25% of hemodialysis sessions complicated by intradialytic hypotension exclusion criteria: * active malignancy * life-threatening conditions * pregnancy * recent participation in another clinical trial for intradialytic hypotension * history of hypersensitivity or contraindication to herbal medicine

Keywords: intradialytic hypotension chinese herbal medicine gui-lu-er-xian-jiao
evaluating the safety and efficacy of sb injection in patients with advanced or metastatic gastric cancer

Conditions: Gastric Cancer

Summary: the purpose of this study is to determine efficacy of sb injection in gastric cancer.

all eligible patients will receive sb injection therapy for 6 cycles (14\~21 days for each cycle). efficacy will be evaluated every 3 cycles.

Eligibility criteria:
inclusion criteria: * age of 18years or over * patients who had failed more than 1 cycle of standard therapy with advanced or metasatic stage and with measurable lesions * life expectancy \>/= 5 months * not available to any of resectable surgery or radiotherapy * patients with adequate organ(e.g. heart, kidney, liver)and bone marrow function, as defined by 1. absolute neutrophil count(anc)\>/= 1.0 x 10\^9/l, platelet count \>/= 75 x 10\^9/l 2. total bilirubin \< 2.0mg/dl 3. aspartate aminotransferase(ast) and/or alanine aminotransferase(alt) \< 5 x upper limit normal(uln) 4. creatinine \< 2 x uln * ecog status 0 to 2 * female volunteers admitted to the study must be using a reliable means of contraception and must have a negative blood or urine pregnancy test at least 7days ago * patients or their legal representatives who have signed the informed consent form. exclusion criteria: * known brain or spinal cord metastases * patients who have received chemotherapy within the previous 4 weeks * patients who have received radiotherapy related tp gastric cancer within 4weeks * patients who have participated in other clinical study within the previous 4weeks * pregnancy (absence to be confirmed by ß-hcg test) or lactation period * human immunodeficiency virus(hiv) antibody (+) * have active infection or serious concomitant systemic disorder incompatible with the study * clinically hypertension or diabete mellitus not well controlled with medication * clinically significant cardiac disease(e.g. congestive heart failure, symptomatic coronary artery disease and cardiac arrhythmias) or myocardial infarction * presence or history of malignancy other than gastirc cancer within 5years * have severe neurologic or psychological disorder * patients who have history of allery with this investigational drug(sb injection) * obvious cognitive or physical impairment that would prevent participation
the effect of ischaemic-reperfusion and remote ischaemic preconditioning in man - a bradykinin dependent pathway

Conditions: Ischaemic Heart Diseases

Summary: heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. current treatments are designed at relieving this blockage as quickly as possible to minimize damage to the heart muscle. however in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. the aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. this will help the investigators to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.


Eligibility criteria:
inclusion criteria: * healthy males between 18-65 years of ages. * non-smokers. exclusion criteria: * any concurrent illness or chronic medical condition. * concurrent use of vasoactive medication. * smoking history.

Keywords: ischaemia reperfusion platelet activation endothelial function remote ischaemic preconditioning bradykinin
objective quality of life detection validation

Conditions: Parkinson Disease

Summary: the purpose of this research study is to: * collect data to use in the development of a standardized tool for identifying patients with parkinson's disease (pd) who would benefit from advanced therapies (at) such as deep brain stimulation (dbs) and drug pumps. * determine the level to which specific activities reflect with quality of life in individuals with pd. * obtain feedback from individuals with parkinson's disease and clinicians on the usability of the system.

the investigators aim to develop a standardized tool for identifying patients with parkinson's disease (pd) who would benefit from advanced therapies (at) and identify when at recipients are in need of a therapy adjustment. this system will integrate ambulatory pd monitoring with context aware activity detection as the daily activities a patient performs are often the best predictors of quality of life (qol). in this study the kinesia 360 system will collect motion data to measure tremor, bradykinesia (slow movement), and dyskinesia (involuntary movements) from individuals with pd to track their symptoms throughout the day. a smartphone will collect information on subject location and activity using the gps, accelerometers, and microphone within the phone to find correlations between activity and patient wellness. this data will be used to improve detection over time and predict whether patients are candidates for advanced therapies.

Eligibility criteria:
inclusion criteria: 1. able to provide informed consent 2. diagnosed with pd 3. hoehn and yahr scale i-iii 4. able to travel to great lakes neurotechnologies 5. ambulatory and capable of using the kinesia 360 system 6. able to understand and follow instructions regarding using the device exclusion criteria: any subject that does not meet the subject selection criteria will be excluded from this study. children will be excluded from this study due to the fact that they are unlikely to have pd. subjects that are not capable of functioning independently or are so symptomatic as to compromise their safety will also be excluded.
treatment of hypersensitivity using diode laser and desensitising agent on fluorosed and non-fluorosed teeth

Conditions: Fluorosis, Dental; Non-Fluoride Enamel Opacities; Dentin Sensitivity

Summary: the present study was designed as a randomised controlled clinical trial which was unicenter, double-blinded, parallel designed study, according to the consolidated standards of reporting trials (consort) criteria, 2010. the study period was from july 2014 to september 2015.

90 patients visiting the out patient of department of periodontology, krishnadevaraya college of dental sciences and hospital, bengaluru, india, presenting with a chief complaint of dentinal hypersensitivity were enrolled in the study. patients' age ranged from 18-60 years. the subjects interested in participating were explained in detail the treatment protocol. a verbal consent as well as a written informed consent was obtained from each patient treatment of dentinal hypersensitivity with a combination of diode laser and potassium nitrate desensitising agent was considered as the test group and this was compared with diode lasers alone and desensitising agent alone as the positive control groups. the study was conducted in full accordance with the declared ethical principles (world medical association declaration of helsinki, version vii, 2013)13 and was approved by the institutional review board of krishnadevaraya college of dental science and hospital, under the registration number of (aca/dcd/syn/kcods - b/pg/2013-2014).

Eligibility criteria:
inclusion criteria: * • patients with a positive response for hypersensitivity testing (pashley, 1990) i.e. cold water testing using ice cold water (trowbridge et al., 1980), * air blow test (coleman and kinderknecht, 2000), * electric tactile stimulation test (camps and pashley, 2003), * patients presenting with non-carious cervical lesions in the enamel (loomba et al., 2013), fluorosed teeth wherein fluorotic enamel staining confirmed by clinical examination, healthy non fluorosed teeth, which was confirmed by clinical examination (dean, 1934). exclusion criteria: * the following were set as the exclusion criteria; * patients undergoing any form of restorative endodontic, * orthodontic treatment or crown restorations, * local defects including caries and fractures, * presence of any systemic diseases, * acute pain conditions (like apical periodontitis, periapical abscess), * presence of periodontal disease or a history of periodontal treatment in last 6 months, * usage of desensitising toothpaste or mouth rinse in the last 4 weeks, * patients allergic to ingredients used in the study product, * teeth with intrinsic stains caused by other reasons.
prospective liver study

Conditions: Liver Cancer

Summary: this study is designed for patients diagnosed with liver cancer to collect information about the relationship between types of liver cancer, methods of treatment and outcomes over time.


Eligibility criteria:
inclusion criteria: * patients diagnosed with hepatocellular carcinoma and referred for percutaneous liver treatment. exclusion criteria: * severe liver disfunction * active uncontrolled infection * significant underlying medical of physical illness

Keywords: hepatocellular carcinoma liver metastases cholangiocarcinoma percutaneous treatments rfa tace deb
increasing the accessibility of a falls prevention intervention for community dwelling older adults with low vision

Conditions: Low Vision; Fall

Summary: this study serves to test a previously evaluated falls prevention intervention recommended by the centers for disease control and prevention, entitled the study of accidental falls in the elderly (safe) health behavior and exercise intervention, to evaluate if the intervention is accessible to older adults with low vision receiving services from the southeastern blind rehabilitation center (sbrc). this study also serves to pilot a version of the safe intervention that has been adapted to be accessible for individuals with low vision at sbrc.

this study serves to compare the comprehension and retention of individuals completing a version of the safe falls prevention intervention adapted for low vision versus individuals receiving the original intervention. one group of participants will complete the standard safe intervention format while another group will complete the same intervention with written materials adapted for those with vision loss. one intervention (either standard or adapted safe program) will be delivered at a time. the safe intervention is comprised of four, 90-minute group classes that address environmental, behavioral, and physical falls risk factors. classes involve lecture and group discussions as well as review of low intensity exercises. the adapted content is presented in large print with high contrast and has been rewritten on a lower grade level. a nutritionist, a physical therapist, a physician, 5 older adults with low vision, 10 low vision occupational therapist, and 5 health literacy experts provided feedback to strengthen the adapted intervention.

Eligibility criteria:
inclusion criteria: * 60 and older; * visual impairment with some remaining reading ability. exclusion criteria: * less than age 60; * complete blindness; * vertebral osteoporosis.
comparative analysis of heart rate variability in patients with cervical pain, lumbar pain, and healthy controls

Conditions: Chronic Low Back Pain (CLBP); Chronic Neck Pain; Heart Rate Variability; Autonomic Nervous System Dysfunction

Summary: this is a cross-sectional study designed to evaluate potential differences in heart rate variability (hrv) indices based on the affected body region (cervical vs lumbar) in individuals with chronic pain. the study will compare hrv parameters between three groups: individuals with chronic neck pain (cnp), individuals with chronic low back pain (clbp), and a control group without pain. hrv will be assessed using a firstbeat bodyguard® device over a 10-minute period, and the data will be analyzed with kubios® hrv software. the study aims to determine whether autonomic nervous system modulation differs depending on the location of chronic pain.


Eligibility criteria:
inclusion criteria: * - adults aged between 18 and 65 years. for the chronic low back pain group: * diagnosis of chronic neck or low back pain lasting at least three months. * a minimum pain intensity of 3/10 on the numerical pain rating scale (nprs). for the healthy group: * absence of any chronic or acute pathology. * no regular medication that could alter autonomic nervous system function. * no episodes of low back pain in the past six months. exclusion criteria: * presence of uncontrolled neurological or cardiac disorders. * use of medications that could influence autonomic function or pain perception (e.g., opioids, antidepressants, benzodiazepines, anti-inflammatory drugs, beta-blockers) within two weeks prior to the study. * body mass index (bmi) equal to or greater than 30 kg/m².
study: effects of potatoes in a weight loss program

Conditions: Obesity

Summary: the purpose of this study is to test whether diets that contain potatoes and differ in glycemic index/load will be useful in weight loss, blood sugar control and maintaining current body weight.

the study will examine the effect of including potatoes as part of a calorie restricted diet designed to induce weight loss and improve glycemic control in overweight subjects. this is a randomized, treatment-controlled, 3-arm, parallel study. the 3 arms of the study will include dietary manipulation in the free-living setting to include potatoes/potato products frequently in the diet (5-7 days / week). two diets will be energy-restricted (\~ 500 kcal deficit /d) for weight loss and the control diet will be prescribed for weight maintenance. the two energy-restricted diets will include further manipulation, such that, one dietary plan will be a high glycemic index (gi) diet and the other a low glycemic index diet.

Eligibility criteria:
inclusion criteria: * men and women * ≥ 18 years of age who have a body mass index (bmi) of 25 to 35 kg/m2 (inclusive). exclusion criteria: * total cholesterol (tc) not greater than 300 mg/dl, * fasting triglyceride not greater than 300 mg/dl , * ldl cholesterol (ldl-c) not greater than 180 mg/dl, * smokers * female subjects who are pregnant or lactating * subjects taking any medications that would interfere with outcomes of the study * subjects with unusual dietary habits (eg., pica) * subjects who are actively losing weight or trying to lose weight * subjects who are addicted to drugs or alcohol or who are \< 1 y in recovery program * subjects who present with significant psychiatric or neurological disturbances * subjects with known allergy or intolerance to potato products * subjects with documented atherosclerotic disease, inflammatory disease, diabetes mellitus, uncontrolled hypertension ( 140/90 mm hg), chronic lung, renal or liver disease

Keywords: weight loss potatoes dietary meetings glycemic control
metabolism in the human brain following consumption of a keto-ester in alcohol use disorder (aud) with proton magnetic resonance spectroscopic imaging (mrsi)

Conditions: BHB Transport; Alcohol Use Disorder

Summary: the objective of this study is to determine whether bhb levels in the brain will be positively associated with alcohol consumption, due to hypothesized enhancement of bhb transport into the brain.

the primary objective of this study is to determine whether bhb levels in the brain will be positively associated with alcohol consumption, due to hypothesized enhancement of bhb transport into the brain. furthermore, bhb levels in identified brain regions will be compared against measures of craving. the secondary objective of this study is to investigate if gaba levels will be elevated in key brain regions relative to the baseline scan in ac subjects due to preferential bhb metabolism. the goal is to acquire preliminary data to apply for an r01 or equivalent grant submission to pursue this metabolic therapy in greater detail using the state-of-the-art mrsi platform at yale university to study alcohol use disorders.

Eligibility criteria:
inclusion criteria: * for aud patients: individuals assessed to be with mild to - medium severity according to the dsm-5 criteria. * for non-dependent heavy at-risk drinkers: must be individuals who consume more than 14 drinks per week for men or more than 8 drinks per week for women, for at least the last 2 months. * for healthy controls: must be light drinkers not dependent on alcohol, who consume fewer than 2 drinks per week for at least the last 6 months. * english speaking * can read and understand a study the consent form exclusion criteria: * non-english speaking * unable to read and understand the consent form * history of alcohol withdrawal in the last 12 months. this will reduce chances of a volunteer having withdrawal symptoms in the middle of the experiment. * participants with a history of psychiatric conditions (that include ptsd, schizophrenia, and bipolar disorders), or a history of neurological conditions * women who test positive on a pregnancy test collected on either the screening visit or day of the study. * healthy subjects identified with substance use with the exception of tobacco and alcohol will be excluded. * ac subjects identified with substance use, with the exception of tobacco, alcohol, and mild cannabis use disorder (based on the dsm-5 criteria during the medical history) in the last 6 months, will be excluded. * persons unable to refrain from alcohol use for 48 hours and undergo a 10-hour fast prior to the study

Keywords: bhb aud