Kornimate/medical-research-clean huggingface dataset:
phase 2 study of otl38 for intra-operative imaging of folate receptor-alpha positive ovarian cancer

Conditions: Ovarian Cancer

Summary: this study is being done to: * test the safety of otl38 * see if otl38 helps light up the cancer when viewed with the special camera system * test the safety of the special camera system for use along with otl38 during surgery


Eligibility criteria:
inclusion criteria: 1. female patients 18 years of age and older 2. have a primary diagnosis, or at high clinical suspicion, of primary ovarian cancer (of epithelial type), planned for primary debulking or interval debulking surgery, and: * who are scheduled to undergo laparotomy for the debulking surgery or * who are scheduled to undergo laparoscopy and pre-authorized to undergo laparotomy for the debulking surgery, if cancer is detected on the laparoscopy 3. a negative serum pregnancy test at screening followed by a negative urine pregnancy test on the day of surgery or day of admission for female patients of childbearing potential 4. female patients of childbearing potential or less than 2 years postmenopausal agree to use an acceptable form of contraception from the time of signing informed consent until 30 days after study completion 5. ability to understand the requirements of the study, provide written informed consent and authorization of use and disclosure of protected health information, and agree to abide by the study restrictions and to return for the required assessments exclusion criteria: 1. previous exposure to otl38 2. known fr alpha-negative ovarian cancer 3. planned surgical approach via laparoscopy or robotic surgery 4. any medical condition that in the opinion of the investigators could potentially jeopardize the safety of the patient 5. history of anaphylactic reactions or severe allergies 6. history of allergy to any of the components of otl38, including folic acid 7. pregnancy, or positive pregnancy test 8. clinically significant abnormalities on electrocardiogram (ecg) 9. presence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule 10. impaired renal function defined as egfr\< 50 ml/min/1.73m2 11. impaired liver function defined as values \> 3x the upper limit of normal (uln) for alanine aminotransferase (alt) or aspartate aminotransferase (ast), alkaline phosphatase (alp), or total bilirubin. 12. known stage iv ovarian cancer with brain metastases 13. received an investigational agent in another investigational drug or vaccine trial within 30 days prior to surgery 14. known sensitivity to fluorescent light
post-traumatic stress disorder after pediatric intensive care unit hospitalization

Conditions: Post-traumatic Stress

Summary: the elements that promote the development of post-traumatic stress in parents following hospitalization in pediatric resuscitation and thus the options for improving initial care at the time of hospitalization are unknown. it is therefore important to describe the prevalence of post-traumatic stress disorder with current pediatric resuscitation management data, but also to possibly describe the factors associated with it in order to optimize initial management.


Eligibility criteria:
inclusion criteria: - all parents of children aged 0 to 18 who have been admitted in paediatric resuscitation unit. exclusion criteria: * holders of parental authority who cannot answer the questionnaire because they do not speak french. * opposition of one of the two holders of parental authority * minor parental authority holders * holders of parental authority under safeguarding of justice or guardianship
dvd-based training program in self-hypnosis for children

Conditions: Vesicoureteral Reflux

Summary: the proposed study is designed to utilize a self-hypnosis dvd home-training program for parents to use with their children to teach self-hypnosis techniques for inducing relaxation and hypnotic analgesia. these relaxation techniques can be employed to manage anticipatory anxiety, distress, and pain during an invasive medical procedure, for example, voiding cystourethrography (vcug). the study will examine the efficacy of this intervention for children undergoing vcug procedures.

pediatric care professionals and parents seek safe ways to make invasive medical procedures less stressful and traumatic for children. however, for unpleasant procedures that require child cooperation, this task becomes difficult. home-training in self-hypnotic relaxation may provide an inexpensive, yet systematic method for improving the overall medical care of children undergoing invasive medical procedures. the proposed study is designed to utilize a self-hypnosis dvd home-training program for parents to use with their children to teach self-hypnosis techniques for inducing relaxation and hypnotic analgesia. the study will examine the efficacy of this intervention for children undergoing urethral catheterization for vcug procedures. parents will be instructed to watch the dvd and practice the self-hypnosis exercises every day for a week with their child prior to the upcoming procedure. parents are encouraged to practice self-hypnosis during their child's vcug procedure. both parents and children will be asked to complete a series of questionnaires before and following the procedure.

Eligibility criteria:
inclusion criteria: * child and participating parent have assented (child) or consented (parent) to participate * both child and parent are english-speaking * child has undergone at least one previous vcug * child was at least 4 years of age at the time of the most recent vcug * parent reports child experienced some difficulty (e.g., at least some crying, pain, or fear) during that earlier procedure. exclusion criteria: * child and participating parent have not assented (child) or consented (parent) to participate * either child or parent are not english-speaking * child has not undergone at least one previous vcug * child was under 4 years of age at the time of the most recent vcug * parent reports child did not experience difficulty (e.g., at least some crying, pain, or fear) during that earlier procedure.

Keywords: vcug child hypnosis relaxation voiding cystourethrography
post-mi pet scan imaging of inflammation

Conditions: Acute Myocardial Infarction

Summary: restoring the patency of the coronary vessels and providing the ischemic myocardium with reperfused blood can cause additional tissue damage. a key element of ischemia and reperfusion (i/r) injury and major determinant of the evolution of damage in the affected myocardium is the inflammatory response. the main objective of the study is to evaluate the efficacy of colchicine in reducing i/r injury by effectively modulating the inflammatory response in the reperfused myocardium.


Eligibility criteria:
inclusion criteria: * the study will enroll patients 18 years old or older * who presented to the hospital within twelve (12) hours of the onset of chest pain -who had st segment elevation \> 1 mm in two contiguous limb leads or st segment elevation \> 2 mm in two consecutive precordial leads or new onset of left bundle branch block (lbbb) in a twelve lead electrocardiogram and for whom the decision was made to be taken to the cath lab to perform angioplasty of the coronary vessels. exclusion criteria: * excluded patients: * with age \> 80 years old * with active inflammatory diseases, infectious diseases or known malignancy * under treatment with corticosteroids, anti-inflammatory agents or disease modifying agents * with known hypersensitivity-allergy to colchicine * under chronic treatment with colchicine * with severe renal failure (egfr \< 30 ml/min/1.73 m2) * with hepatic failure (child - pugh class b or c) * presented with cardiac arrest * presented with ventricular fibrillation * presented with cardiogenic shock * with stent thrombosis * with angina within 48 hours before infarction * with previous myocardial infarction in the affected territory * with occlusion of the left main or left circumflex coronary or the right coronary artery or with evidence of coronary collaterals to the region at risk on initial coronary angiography (at the time of admission)
predictive value of new amh test method for ovarian response

Conditions: Infertility; AMH

Summary: in china, the incidence of infertility is about 15%, and patients need to use assisted reproductive technology (art) to obtain pregnancy. it is particularly important to accurately predict the patient's ovarian response before initiating controlled ovulation hyperstimulation (coh). at present, the commonly used amh detection method is enzyme-linked immunoassay (elisa), and it has obtained the normal reference range for ovarian response. in recent years, with the development of detection technology, chemiluminescence immunoassay（clia） detection reagents have been successively used for the detection of amh. however, there are few studies on the comparison of these two detection methods. the predictive value of the new method on ovarian response was lack. therefore, by comparing the two methods of elisa and clia detection of amh levels in this study, the predictive value of poor ovarian response (the number of retrieved oocyte ≤ 3) and high response (the number of retrieved oocyte ≥ 15) in ivf/icsi stimulation cycle was analyzed. in order to provide more reference basis for individualized coh, the amh cutoff value of low and high ovarian response by the new method predicts was analyzed. at the same time, the prediction value of the two methods is compared to determine whether the new clia is suitable for clinical application.


Eligibility criteria:
inclusion criteria: * the first ivf/icsi coh cycle; * the causes of infertility :fallopian tube factors and/or male factors; exclusion criteria: * endometriosis; * pcos; * adenomyosis; * pgt cycle because of the female chromosome abnormality or genetic abnormality; * fet cycle; * malignant tumor patient.
outcome after radial pressure wave therapy in plantar fasciitis.

Conditions: Fasciitis, Plantar; Fasciitis, Plantar, Chronic

Summary: the goal of this observational study is to explore potential associations between baseline patient characteristics (such as age, body mass index, and baseline pain intensity) and clinical outcomes in patients with plantar fasciitis undergoing radial pressure wave therapy (rpwt). the study includes male and female adults aged 18 to 60 years.

background: plantar fasciitis (pf) is a common cause of heel pain, significantly impairing functionality and quality of life. radial pressure wave therapy (rpwt) has emerged as a non-invasive therapeutic option. however, there is limited evidence regarding factors that may influence clinical outcomes in patients receiving this treatment. objectives: the primary objective of this study is to explore potential associations between baseline patient characteristics (such as age, body mass index, and pain intensity) and clinical outcomes in patients with pf treated with rpwt. additionally, this study aims to assess changes in pain intensity and functionality following rpwt. materials and methods: this is an exploratory, pilot observational study including patients diagnosed with pf who undergo three sessions of rpwt. the study evaluates changes in pain intensity, assessed using the numerical pain rating scale (nprs), and functionality, measured using the whodas 2.0. patient characteristics such as age, body mass index (bmi), and pf chronicity are collected retrospectively from medical records. statistical analyses will be conducted to examine potential associations between patient characteristics and treatment outcomes.

Eligibility criteria:
inclusion criteria: * diagnosis of plantar fasciitis confirmed by clinical evaluation. * age 18 to 60 years. * symptoms persisting for at least three months before treatment. * completed three rpwt sessions using a standardized protocol (2000 impulses per session, 10 hz, and 3.5 bar). * availability of complete medical records, including three-month follow-up data. exclusion criteria: * history of foot surgery or corticosteroid injection in the affected limb within the past six months. * pregnancy at the time of treatment. * presence of concurrent musculoskeletal conditions (e.g., fractures, active infections, sprains) in the affected limb. * diagnosis of systemic conditions (e.g., cancer, osteoporosis, autoimmune diseases). * incomplete medical records or failure to complete rpwt sessions and follow-up visits.

Keywords: plantar fasciitis rehabilitation outcomes
mri in ovarian tumors

Conditions: Ovarian Neoplasms

Summary: role of multi paramrtric mri and mri perfusion in indetermint ovarian lesions by using orads mri

aim of study the purpose of this study is to investigate the capabilities of multi parametric mri including dce perfusion and dwi to discriminate between benign and malignant ovarian masses .

Eligibility criteria:
inclusion criteria: females with ovarian masses - exclusion criteria: * females with known benign ovarian masses
a study to estimate the amount of cp-690,550 (study drug) that is absorbed into the blood of healthy subjects following oral administration of cp-690,550 in tablet form

Conditions: Healthy

Summary: in this study, a 10 mg dose of cp-690,550 will be given to study subjects on two separate occasions by two different routes of administration: one time by mouth in tablet form and one time by vein (intravenous form). the amount of cp-690,550 available in the blood following administration by vein will be measured and is expected to reflect the maximum amount possible for the 10 mg cp-690,550 dose. the amount of cp-690,550 that is achieved in the blood following oral tablet administration will also be measured and compared to that achieved following administration by vein in order to estimate how much of the maximum amount possible is actually absorbed into the blood following administration by mouth as a tablet.

to estimate the absolute bioavailability of a 10 mg oral dose of tasocitinib (cp-690,550) compared to a 10 mg intravenous dose of tasocitinib (cp-690,550) in healthy subjects.

Eligibility criteria:
inclusion criteria: * healthy male and/or female (non childbearing potential) * subjects between the ages of 21 and 55 years, inclusive * body mass index (bmi) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs) * no evidence of active or latent or inadequately treated infection with mycobacterium tuberculosis (tb) exclusion criteria: * evidence or history of any clinically significant illness, medical condition, or disease. 2. evidence or history of any clinically significant infections within the past 3 months. 3. use of tobacco- or nicotine-containing products in excess of the equivalent of 5 cigarettes per day.

Keywords: absolute bioavailability rheumatoid arthritis
monopolar and bipolar in esophageal esd

Conditions: Esophageal Neoplasm; Esophageal Polyp; Endoscopic Submucosal Dissection; Bipolar Electocautery

Summary: the objective of this study is to prospectively document the efficacy and clinical outcomes of endoscopic submucosal dissection procedure that utilize either a novel bipolar-current esd device or the standard monopolar electrocautery knife.

endoscopic submucosal dissection (esd) is a novel technique for the removal of esophageal lesions or polyps with high-risk features. esd is minimally invasive and allows the removal of esophageal polyps without resorting to morbid surgery. the process of esd includes marking the lesions selected for removal, followed by submucosal injection of a lifting agent, then circumferential incisions using a specialized knife followed by submucosal dissection of the entire lesion. traditionally, knifes utilizing monopolar current such as dual knife or hybrid knife were the preferred tools for endoscopic submucosal dissection. these knifes allows accurate dissection and excellent hemostasis. however, due to monopolar current generated heat, post coagulation syndrome can be seen in up to 8 to 40 % of patients. post coagulation syndrome present with pain, fever and leukocytosis and requires supportive treatment with iv fluid and antibiotics. in addition, for large esophageal lesions, stricturing can occur after resection due to significant scar formation induced by large amounts of energy. almost all patients with 60% of the esophageal circumference removed via monopolar knives, will develop an esophageal stricture at some point. these patients require serial esophageal dilations, and although easily managed, its development can be quite troublesome to the patient. nevertheless, esd is still the preferred modality for removal of these lesions, since it avoids the need for morbid surgery. recently, a novel bipolar rfa knife were approved by fda for the performance of esd. the knife utilizes bipolar rfa current for submucosal dissection which can potentially expedite submucosal dissection and decrease the rates of post polypectomy syndrome and scar formation, by using significantly less energy. this bipolar knife may allow for removal of large esophageal lesions without causing major esophageal stricturing. our tertiary referral center baylor st luke's medical center is a center of excellence for esd procedure and the investigators have previously reported our esophageal esd experience using the monopolar current knife. the goal of our protocol is to compare the performance of monopolar current cutting knife and bipolar rfa knife in esophageal endoscopic submucosal dissection.

Eligibility criteria:
inclusion criteria: * patient is ≥ 18 years old * patient is capable of providing informed consent * patient is referred for esd procedure of an esophageal neoplastic lesion exclusion criteria: * patient is \< 18 years old * patient refused and/or unable to provide consent * patient is a pregnant woman * patients with lesions removed with other techniques besides esd (i.e. cap emr) or a modified esd technique
neurological dry eye study stimulating both lacrimal and vagus nerves

Conditions: Dry Eye Disease; Dry Eye

Summary: this is a study on neurological dry eye disease, focusing on a patented over-the-counter supplement supporting tear production neurologically, including the lacrimal and vagus nerves.

chronic inflammation is implicated in the majority of chronic dry eyes. the parasympathetic nervous system is responsible for both basal tear secretion (the aqueous layer) by the lacrimal functional unit, and is responsible for controlling many aspects of chronic inflammation via the vagus nerve. this study will document its effects on dry eyes, in addition to other symptoms/signs of low parasympathetic nervous system functioning using an over-the-counter supplement.

Eligibility criteria:
inclusion criteria: * must have dry eye (osdi score 30 and above) * tear break up time of less than or equal to 7 seconds * must be able to come for baseline tests and again at 4 weeks exclusion criteria: * demodex * corneal scarring * must not take physostigmine (glaucoma), pyridostigmine (mestinon), neostigmine (for myasthenia gravis); aricept (for alzheimer's), or ingredients to neurotears * no known allergies to ingredients in neurotears

Keywords: vagus nerve ehlers-danlos syndrome eds lacrimal nerves dry eye tear production dysautonomia pots postural orthostatic tachycardia syndrome constipation gastroparesis tachycardia neurotears mast cell activation syndrome vagus nerve stimulation mcas post-covid covid longhaulers
efficacy study of evo301 in moderate to severe atopic dermatitis

Conditions: Atopic Dermatitis (AD); Eczema; Eczema Atopic Dermatitis

Summary: this is a phase 2a efficacy and safety study of evo301 for the treatment of adults with atopic dermatitis.

this is a phase 2a efficacy and safety study of intravenous evo301 in adults with moderate to severe atopic dermatitis.

Eligibility criteria:
inclusion criteria: 1. males or non-pregnant, non-lactating females, age 18 years or older 2. chronic atopic dermatitis for at least 6 months 3. bsa of ad involvement of at least 10% 4. easi score of at least 16. exclusion criteria: 1. significant ad flare with 4 weeks 2. use of biologic therapy within 12 weeks 3. regular use of tanning booth within 4 weeks 4. skin condition that could interfere with study assessments

Keywords: atopic dermatitis eczema
faith in action! a church-based navigation model to increase breast cancer screening in korean women

Conditions: Breast Cancer Female; Health Knowledge, Attitudes, Practice; Cancer Screening; Health Disparities

Summary: the purpose of this research is to develop a culturally adapted "faith in action!" curriculum to train lay health navigators to provide breast cancer screening navigation to korean american women within faith-based settings and evaluate whether the culturally adapted "faith in action!" curriculum increases adherence to breast cancer screening guidelines among korean american women within faith-based settings in los angeles, california. the primary research procedures include trainings and key informant interviews with lay health navigators in faith-based settings followed by a cluster randomized trial to evaluate the intervention.

a parallel cluster randomized trial (crt) with staggered roll-out will be conducted to evaluate the efficacy of the "faith in action!" intervention on breast cancer screening rates among korean american women. this will involve two blocks of 8 churches each (total 16 churches) randomized to either the intervention or waitlist control. a train the trainer approach will be used to educate and certify lay health navigators identified by targeted korean church leaders from selected churches. the trained health navigators will be deployed back to the churches and community settings with tools and resources to deliver cancer education and increase motivation to participate in breast cancer screening through proven approaches such as one-on-one education, small media and workshops. the research objectives are to: 1. develop a culturally adapted "faith in action!" curriculum to train lay health navigators to provide breast cancer screening navigation to korean american women within faith-based settings. 2. evaluate whether the culturally adapted "faith in action!" curriculum increases adherence to breast cancer screening guidelines among korean american women within faith-based settings. it is hypothesized that the implementation of this culturally adapted cancer screening training curriculum for lay health navigators, built upon the korean communities' frequent engagement with "expert" schools and deployed among existing networks in the faith-based korean community, will increase adherence to breast cancer screening guidelines among underserved korean american women.

Eligibility criteria:
inclusion criteria: * korean woman who is 45 years or older * does not currently have a breast cancer diagnosis * non-adherent to cancer screening (did not receive mammogram in last 2 years based on self-report) * prospective or current member of participating korean churches * willing to participate in study exclusion criteria: * does not meet inclusion criteria as described above