Kornimate/medical-research-clean huggingface dataset:
assessing the reliability of non-invasive blood glucose monitoring device

Conditions: Diabetes Mellitus

Summary: adequate glycemic control in patients with diabetes mellitus (dm) is a desired therapeutic goal that is difficult to achieve with current blood glucose monitoring technology. home blood glucose monitoring (hbgm) technology, which requires finger pricking, is a source of severe inconvenience and hence, a lack of compliance.thus, the need for non-invasive and easy to operate glucose monitoring in dm patients for strict glycemic control cannot be overemphasized. the glucometer gm-205 blood glucose readings are accurate and measure blood glucose with an acceptable mean relative error when compared to acceptable invasive blood glucose measurements. the primary objectives of the trial are to determine: 1. assessing the reliability of the glucometer gm-205 in evaluating blood glucose levels compare to the standard glucose blood test 2. creating database of glucose levels readings utilizing the glucometer gm-205.


Eligibility criteria:
inclusion criteria: 1. diabetes mellitus type one or type two. 2. patients that are using insulin. exclusion criteria: 1. vascular diseases 2. pregnant and lactating women. 3. exclusive use of long term insulin.
hiv- risk reduction behavioral intervention for commercial sex workers in yerevan armenia

Conditions: HIV Prevention; HIV Infections

Summary: this pilot study will test the efficacy of a behavioral intervention in reducing hiv related risk behaviors among sex workers in yerevan, armenia.

the purpose of this pilot study is to evaluate the efficacy of an intervention to reduce sexual risk behaviors and enhance hiv-preventive behaviors among female sex workers (fsws) in yerevan, armenia. the study design is a randomized controlled trial of 120 fsws aged 18 and over recruited through hope and help ngo. participants will complete an interviewer administered questionnaire collected at baseline, 3- and 6-month follow-up. subsequently, participants will be randomly assigned to either the intervention condition or a wait-list control. those randomized to the intervention condition will receive a 2-hour one-on-one intervention session emphasizing hiv knowledge, self-efficacy, and condom use behaviors. they will also receive a 10-15 minute booster session at 3-month follow-up. the comparison condition is wait-listed, but have the choice of participating in the intervention program upon completion of the study. the main outcome measure includes consistent condom use, defined as condom use during every episode of vaginal intercourse with clients. other outcome measures are condom application by fsw and hiv- preventive behaviors such as condom use self-efficacy, knowledge of hiv transmission dynamics,perceived barriers to condom use and condom use errors. results from this pilot study are expected to inform a larger trial to be implemented with fsws in armenia, in an effort to devise gender and culturally relevant intervention programs to prevent hiv transmission in this vulnerable population.

Eligibility criteria:
inclusion criteria: * 18 years and older * traded sex for money in the past 7 days * cognitive ability to participate in assessment and intervention exclusion criteria: * younger than 18 years of age * did not trade sex for money in the past 7 days * cognitively unable to participate in assessment and intervention

Keywords: hiv prevention, female sex workers hiv seronegativity
bangladesh vitamin e and selenium trial

Conditions: Non-melanoma Skin Cancer

Summary: the purpose of this study is to evaluate whether selenium and/or vitamin e are effective in preventing non-melanoma skin cancers.


Eligibility criteria:
inclusion criteria: * manifest arsenic skin lesions (melanosis, leucomelanosis, or keratosis) * aged 25 to 65 years * permanent resident of study area exclusion criteria: * pregnancy * clinically too ill (enlarged spleen or liver) * presence of gangrene * cancer
clinical outcome of birmingham hip resurfacing (bhr) using visionaire femoral alignment guide

Conditions: Osteoarthritis

Summary: the primary objective of this study is to investigate the accuracy of the femoral implant placement utilizing the visionaire femoral alignment guide in birmingham hip resurfacing (bhr) surgery postoperatively after total hip resurfacing using the bhr system.

this is a prospective, multi- site, clinical study of clinical outcomes following hip resurfacing using visionaire femoral alignment guide. the objective of this study is to evaluate the safety and efficacy of the blocks and to assess alignment of the bhr system when using visionaire femoral alignment guide. this study will also document any device-related surgical complications or adverse radiographic observations.

Eligibility criteria:
inclusion criteria: 1. males or females, at least 21 years of age, inclusive, and skeletally mature. 2. patient diagnosed with osteoarthritis of the hip requiring primary total hip resurfacing due to: * non-inflammatory arthritis (degenerative joint disease) such as osteoarthritis, traumatic arthritis, avascular necrosis, or dysplasia/ddh, or * inflammatory arthritis such as rheumatoid arthritis. 3. patient is willing to consent to participate in the study 4. patient is in stable health and is free of or treated and stabilized for cardiac, pulmonary, hematological, or other conditions that would pose excessive operative risk. 5. patient meets medical clearance to have surgery required for this study exclusion criteria: 1. patient with infection or sepsis. 2. patient with any vascular insufficiency, muscular atrophy, or neuromuscular disease severe enough to compromise implant stability or postoperative recovery. 3. patient is pregnant or plans to become pregnant during the course of the study. 4. patient known to have insufficient bone stock to support the bhr device including: * subjects with severe osteopenia should not receive a bhr procedure. patients with a family history of severe osteoporosis or severe osteopenia. * subjects with osteonecrosis or avascular necrosis (avn) with \>50% involvement of the femoral head (regardless of ficat grade) should not receive a bhr. * subjects with multiple cysts of the femoral head (\>1cm) should not receive a bhr. * note: in cases of questionable bone stock, a dexa scan may be necessary to assess inadequate bone stock. 5. patient has known moderate to severe renal insufficiency. subjects on medications (such as high-dose or chronic aminoglycoside treatment) or with co-morbidities (such as diabetes) that increase the risk of future, significant renal impairment should be advised of the possibility of increase in systemic metal ion concentration. 6. patient has a known sensitivity to materials in the device. 7. patient is immuno-suppressed. 8. patient has physical, emotional or neurological conditions that would compromise the patient's compliance with postoperative rehabilitation and follow-up. 9. patient has bmi \>40.
dual-energy ct on plan quality, dose-delivery accuracy, and simulated outcomes of patients treated with proton or photon therapy

Conditions: Lung Cancer; Brain Cancer; Head and Neck Cancer

Summary: the aim of this protocol is to refine the accuracy of proton beam therapy (pt) by the use of dual energy computed tomography (dect), in conjunction with novel iterative image reconstruction algorithms, to more precisely determine the tissue properties through which the proton beam path travels.


Eligibility criteria:
eligibility criteria: inclusion criteria: * diagnosis of histologically proven primary or metastatic cancer requiring thoracic radiation therapy or radiation therapy to the head and neck or brain * at least 18 years of age. * planning to undergo proton or photon beam radiation therapy as part of the clinical management of the diagnosed cancer. * able to understand and willing to sign an irb-approved written informed consent document. exclusion criteria: * implanted metallic objects in the region to be scanned excepting dental prostheses * iv or oral contrast medium within 24 hours prior to dect image acqusition * pregnant.
hepatic excision and ablation log

Conditions: Malignant Liver Tumor; Benign Liver Tumor

Summary: this study aims to establish a registry for liver surgery and ablation procedures to improve patient care, advance research, and enhance surgical quality. the registry will collect pseudonymized data on patient demographics, disease characteristics, procedural details, and outcomes.

the purpose of this registry is to create a comprehensive list of individuals who have undergone liver surgery or liver ablation, allowing researchers and clinicians to assess their data in future studies if they meet the eligibility criteria. all patients who have received liver surgery or liver ablation procedures at our institution will be included in this registry. information collected as part of the registry will be used solely to assess potential participants' eligibility for research studies, allowing for the evaluation of long-term outcomes, identification of risk factors, and investigation of therapeutic interventions. this data will help to enhance the understanding of the patient population undergoing liver surgery and improve clinical practices. a patient registry is an organized system that uses observational study methods to collect standardized clinical data and other relevant information. it aims to evaluate specific outcomes for individuals who have undergone liver surgery or ablation, serving scientific, clinical, and policy-related purposes. the registry will support the development of targeted research studies and provide valuable insights into the treatment and management of liver diseases.

Eligibility criteria:
inclusion criteria: * both benign and malignant liver lesions are included exclusion criteria: - intervention performed solely for liver biopsy, without any subsequent surgical resection or ablation.
efficacy of dry needling in the spasticity post-stroke

Conditions: Spasticity, Muscle

Summary: stroke is a serious clinical condition and one of the leading causes of long-term disability in the world. one of the most serious complications of this condition is spasticity. recently, dry needling has commented to be used as a treatment in muscle spasticity of chronic patients after a stroke, producing improvements in clinical conditions. this study evaluates the effectiveness of dry needling technique in the spasticity of the hemiparetic limbs in chronic post-stroke patients. the modified ashworth scale is used to measure the spasticity´s improvement after the procedure.


Eligibility criteria:
inclusion criteria: * first hemiplegic ischemic stroke. * chronic stroke (stroke at least 6 months before the trial). * present a level of spasticity equal or greater than 1 according to the modified asworth scale. * preserve cognitive capacity. * being able to understand and follow simple instructions. * not afraid of needles. exclusion criteria: * recurrent stroke. * subjects with cognitive disorders. * presenting any medical contraindication for the dry needling procedure or problems with coagulation or epilepsy. * alteration of sensitivity. * receives nerve block or botulinum toxin treatments in a period equal or less than 6 months, since ir can modify the results. * hemorrhagic stroke. * subjects who do not consent to participate in the study.

Keywords: dry needling spasticity hypertonia stroke
pulmonary artery denervation in patients with atrial fibrillation and group 2 of pulmonary hypertension

Conditions: Atrial Fibrillation; Pulmonary Hypertension

Summary: the goal of the study is to compare efficacy and safety of the pulmonary artery denervation procedure combined with atrial fibrillation ablation versus atrial fibrillation ablation alone in patients with paroxysmal and persistent atrial fibrillation and group 2 of the pulmonary hypertension


Eligibility criteria:
inclusion criteria: * mean pulmonary artery pressure \> 25 mm hg and pulmonary artery wedge pressure \> 15 mm hg by right heart catheterization * paroxysmal or persistent atrial fibrillation * nyha ii-iii * bnp \> 105 pg/ml * indications for catheter ablation of atrial fibrillation according guidelines * lvef \> 50% exclusion criteria: * group 1,3,4 of the pulmonary hypertension * left atrium diameter \> 6 cm * planned open heart surgery procedure * previous heart valve surgery * severe aortic, pulmonary, tricuspid or mitral, valves regurgitation * thrombus in the left heart chambers

Keywords: atrial fibrillation pulmonary hypertension remote magnetic navigation catheter ablation
is osteopathic manipulative treatment (omt) beneficial for elderly patients hospitalized with pneumonia?

Conditions: Pneumonia

Summary: osteopathic manipulative treatment (omt) were used in the 1800s and 1900s to treat pneumonia before the introduction of antibiotics in the mid-1900s. the purpose of this study is to determine if omt, when used in conjunction with antibiotics and other usual care, will improve the recovery of elderly pneumonia patients.

this study is a multi-center study conducted across five sites in the united states to determine the efficacy of combining osteopathic manipulative treatment(omt)with antibiotics as a treatment regimen for elderly patients with pneumonia. the study is a prospective, randomized, controlled clinical trial, in which 360 subjects will be randomly assigned to three different groups to test the primary hypothesis that the combination of omt and antibiotics will decrease the length of hospital stay for elderly patients with pneumonia. the first group (omt group) will receive a series of eight osteopathic manipulative techniques in combination with conventional antibiotic care. the second group (light touch control group) will receive a light touch mimic treatment in combination with conventional antibiotic care to control for the doctor-patient interaction. the third group (conventional care only group) will receive only the conventional antibiotic care normally given to elderly patients with pneumonia. the first two groups will receive two 15-20 minute treatments per day, at least six hours apart, for the duration of their stay in the acute care facility. the primary outcomes for measuring efficacy are: length of hospital stay, time to clinical stability, and rate of symptomatic and functional recovery. the secondary outcomes are: duration of iv and oral antibiotic usage in the hospital, number of complications and deaths secondary to pneumonia, re-admission rate within 60 days of hospitalization admission date, duration and severity of fever, duration and severity of leukocytosis, and patient satisfaction.

Eligibility criteria:
inclusion criteria: * 50 years old or older * subject is hospitalized in an acute care facility * subject must exhibit at least two of the classic symptoms of pneumonia, to include: * respiration rate greater than or equal to 25 respirations per minute * new or increased cough * fever greater than or equal to 100.4 degrees f (38 degrees c) * pleuritic chest pain * worsening of mental or functional status * leukocytosis (wbc greater than 12,000 cells per cubic millimeter) * new or increased physical findings (rales, wheezing, bronchial breath sounds) exclusion criteria: * lung abscess * advancing pulmonary fibrosis * bronchiectasis * pulmonary tuberculosis * lung cancer * metastatic malignancy * uncontrolled metabolic bone disease that places subject at risk for pathologic bone fracture (i.e. paget's disease or hypoparathyroidism) * acute or unhealed rib or vertebral fracture * history of pathologic bone fracture * previous participants as subject in the study * respiratory failure (intubation)

Keywords: pneumonia osteopathic manipulation multi-center elderly
cobra-slim with or without fast access to tnf blockade for remission induction in early ra

Conditions: Arthritis, Rheumatoid

Summary: in the care in rheumatoid arthritis (carera) trial (nct01172639) about 70% of early ra patients are in remission at the 2 year evaluation point independent of the combination scheme used. interesting to see is that the 30% of insufficient responders can be identified in an early stage of the treatment course. the purpose of the present study is to investigate if, for patients with an insufficient response to a cobra-slim regimen, accelerated access to a short course of anti-tnf therapy already early after treatment initiation (from w8 until w32) could improve outcomes compared to a more traditional treat to target sequence.


Eligibility criteria:
inclusion criteria: * age 18 years and older * diagnosis of ra as defined by the american college of rheumatology (acr)/ european league against rheumatism (eular) 2010 criteria for early ra * early ra defined by a diagnosis made ≤ 1 year ago. * use a reliable method of contraception for women of childbearing potential to be evaluated as in daily clinical practice * able and willing to give written informed consent and to participate in the study * understanding and able to write dutch or french exclusion criteria: * previous treatment with: * methotrexate (mtx) or leflunomide * cyclophosphamide, azathioprine or cyclosporine * sulphasalazine (ssz) for more than 3 weeks * hydroxychloroquine for more than 6 weeks * oral glucocorticoids (gc) for more than 4 weeks within 4 months before screening * oral gc at a daily dosage of more than 10 mg prednisone equivalent within 4 weeks before baseline * oral gc at a daily dosage equal to or less than 10 mg prednisone equivalent within 2 weeks before baseline * intra-articular gc within 4 weeks before bl * an investigational drug for the treatment/prevention of ra * history of chronic heart failure * history of severe infections or chronic infection * history of malignant neoplasm within 5 years * contra indications for gc * contra indications for tnf blocking agents * contra indications for mtx or leflunomide * psoriatic arthritis * underlying cardiac, pulmonary, metabolic, renal or gastrointestinal conditions, chronic or latent infectious diseases or immune deficiency which in the opinion of the investigator places the patient at an unacceptable risk for participation in the study * pregnancy, breastfeeding or no use of a reliable method of contraception for woman of childbearing potential (as in daily clinical practice) * alcohol or drug abuse * active tuberculosis (tb) * latent tb unless adequate prophylactic treatment is given according to local guidelines * no access to the belgian health insurance system-

Keywords: cobra-slim accelerated access to anti-tnf treat to target remission induction
stoma closure and reinforcement trial

Conditions: Colon Cancer; Rectal Cancer; Ileostomy - Stoma

Summary: hernia formation at sites of ostomy closure is a common complication. the investigator believes that using evidence based hernia repair techniques as a preventive measure during closure of ostomies will reduce the incidence of hernia formation. in this trial, the investigator will pilot a novel technique of large pore monofilament polypropylene mesh reinforcement of the abdominal wall defects that remain after closure of an ileostomy to evaluate for safety and begin to evaluate the effectiveness compared to standard techniques.


Eligibility criteria:
inclusion criteria: 1. age \> 18years 2. patient is undergoing closure of loop ileostomy 3. patient has a diagnosis of left sided colon or rectal cancer treated with resection and diverting loop ileostomy 4. patient has been evaluated by a qualified surgeon and found to be a suitable candidate for surgery exclusion criteria: 1. pre-existing systemic infection at the time of ileostomy takedown 2. cirrhosis, chronic renal failure requiring dialysis, or collagen disorder 3. on current immunosuppression (anti-tumor necrosis factor (tnf) agents, chemotherapy, or prednisone \>10mg/day) 4. previous abdominal hernia repair with mesh placement 5. concurrent procedures in addition to closure of diverting loop ileostomy 6. ileostomy closure not completed through the previous stoma site (i.e. those requiring exploratory laparotomy for closure)

Keywords: ileostomy hernia rectal cancer colon cancer
nebulized dexmedetomidine or lidocaine for treatment of post dural puncture headache in parturients undergoing elective cesarean section under spinal anesthesia

Conditions: Pain Score (VAS)

Summary: post-dural puncture headache (pdph) is a well-recognized and potentially serious complication of subarachnoid block. while advancements in spinal needle design have reduced its incidence in recent years, pdph still affects a notable percentage of post-partum patients undergoing spinal anaesthesia, with rates ranging from 0.5% to 2%. factors such as female gender, pregnancy, young age, low body mass index, dilutional anemia, and the preference for neuraxial anaesthesia during caesarean section (cs) increase the vulnerability of obstetric patients to pdph. therefore, managing this complication is critically important in obstetric anaesthesia. the exact cause of pdph remains unclear, but there is substantial evidence suggesting that it stems from reduced cerebrospinal fluid (csf) pressure due to continuous leakage through a dural tear, which exceeds the rate of csf production. this imbalance can lead to pdph, as even a modest loss of csf volume (as little as 10%) can trigger traction on pain-sensitive intracranial structures when in an upright position, compounded by reflexive vasodilation. various treatment strategies have been proposed, typically including bed rest in a supine position, fluid therapy, analgesics, and medications such as sumatriptan and caffeine. dexmedetomidine (dex) is a highly specific agonist of α2-adrenoreceptors known for inducing cooperative sedation, anxiolysis, and analgesia while minimizing respiratory depression. additionally, it has been shown to mitigate the stress and inflammatory response triggered by surgical and anaesthetic procedures. activation of α2-receptors in the substantia gelatinosa of the dorsal horn suppresses the firing of nociceptive neurons and inhibits the release of substance p. furthermore, stimulation of these receptors in the locus coeruleus, a key modulator of nociceptive transmission, interrupts the transmission of pain signals, resulting in analgesia. dexmedetomidine has been administered via intranasal and inhalational routes for various purposes, including premedication, sedation, and post-operative analgesia. lidocaine nebulized is a novel method used recently for pdph. intranasal lidocaine can offer sphenopalatine ganglion block which can facilitate acute pain reduction in pdph.


Eligibility criteria:
inclusion criteria: * post partum headache for parturient with elective cs under spinal anesthesia with visual analog score (vas) ≥ 4 \[14\] and lybecker classification score ≥ 2 exclusion criteria: * emergency caesarean section. * pregnancy induced hypertension * contraindications for sub-arachinoid block ( coagulopathy, infection ) * history of chronic headache, migraine, trigeminal neuralgia * refusal to participate * history of cerebrovascular stroke * bmi\> 35 * history of obstructive sleep apnea.