Kornimate/medical-research-clean huggingface dataset:
investigating the mortality and the morbidity impact of oral polio vaccine at birth

Conditions: Infant, Newborn; Healthy

Summary: our group has discovered that routine vaccinations in childhood may have non-specific and sex-differential effects on overall mortality. the effects are so large that they may have marked effects on overall mortality and seriously distort female-to-male mortality rates in high-mortality settings. we recently experienced periods during which oral polio vaccine (opv) was lacking. hence, some children did not get the recommended opv at birth. we were following all infants as a part of a vitamin a supplementation trial. surprisingly, we discovered that not receiving opv was associated with significantly lower mortality in boys, but not in girls. we bled a subgroup of the children. receiving opv at birth significantly dampened the immunological response to bcg given at birth in both sexes. based on these observations, receiving opv at birth may have two negative effects, first, it may increase male mortality, and second, it may interfere with immunity against tuberculosis. opv at birth is given for logistic reasons, to boost polio immunity. there have been no polio cases in guinea-bissau for the last 10 years. hence, there is every reason to test in a randomised trial whether not receiving opv at birth is associated with 1) mortality, morbidity and growth and 2) immunological response to bcg.


Eligibility criteria:
inclusion criteria:normal birth weight, no overt illness or gross malformations - exclusion criteria: -

Keywords: mortality morbidity growth immunology
corona and manual professions

Conditions: Covid19

Summary: this observational study will follow the chiropractors and naprapaths in sweden to study how work environment, health, and economy is changing during the covid-19 pandemic.

all manual therapists that are members of a professional organization in sweden will be invited to participate. the study started in november 2020 with follow-ups planned after 3,6 and 12 months. all data-collection is taking place with digital questionnaires. there are three main areas of interest: 1. work environment (knowledge about viral contageon, protection, availability of protective measures, disturbances in care for patients) 2. health (physical and psychological, how many caught the virus?) 3. economy (income, costs, turnover)

Eligibility criteria:
inclusion criteria: * chiropractor or naprapath working in sweden * clinically active * belonging to a professional organization exclusion criteria:
evaluation of post operative pain after sonic activation and different irrigation needles during root canal treatment

Conditions: Post Operative Pain

Summary: the study compares the post operative pain after root canal therapy, after using different irrigation protocols. the subjects are divided into 3 groups and different irrigation protocol is used in each group. one group undergoes final irrigation after root canal therapy with a sonic activation device, and in the other two groups, side-vented and open-ended needles are used. post operative pain is then compared at 8, 24, and 48 hour intervals.

root canal therapy is a procedure in which inflamed pulp tissue and microorganisms are removed from root canals and pulp chamber, in order to eradicate infection and symptoms. irrigation is a crucial step of an endodontic therapy and different methods and protocols are used to enhance the efficacy of irrigation. sonic activation of root canal irrigation agent is one of the effective methods that enhance the outcomes and success rate of endo therapies. it removes the smear layer, bacterial biofilms and debris by acoustic streaming and agitating the irrigant inside root canals. similarly, irrigation needles also play an important role in endodontic therapy, particularly by improving the delivery of irrigation agent to the apex of a root canal. conventionally, open ended needles have been used for irrigant delivery inside root canal but is not deemed very efficacious as they cannot penetrate deep into canals and cause extrusion of debris beyond the apex. this problem is solved by using side vented needles of smaller gauge (30 g) that leads to better irrigation and prevent extrusion of chemicals and debris outside the root apex. in this study, the efficacy of all three different irrigation protocols will be compared and assessed based on post-operative pain, measured by visual analog scale (vas).

Eligibility criteria:
inclusion criteria: 1. patients with unremarkable/ noncontributory medical history 2. healthy persons between the ages of 18 and 60 years 3. maxillary and mandibular molar teeth diagnosed with symptomatic irreversible pulpitis. 4. patients not having taken any medication for 12 hours before treatment 5. no allergies to the drugs or dental material being used in the treatment exclusion criteria: 1. patients who had taken analgesics on anti-inflammatory drugs within the last 12 hours 2. pregnant women and patients with immunocompromised health state 3. patients having severe malocclusion associated with traumatic occlusion 4. teeth with calcified canals 5. teeth with periapical radiolucency 6. teeth with root resorption 7. teeth previously undergone root canal treatment

Keywords: sonic activation post operative pain endoactivator side vented needle root canal therapy irrigation
genetic contributions to autism spectrum disorders

Conditions: Autism Spectrum Disorder; Autism; Asperger's Syndrome; Pervasive Developmental Disorder

Summary: this study is working towards gaining a better understanding of the genetic and environmental factors involved in autism spectrum disorders (asd), which includes autism, pervasive developmental disorder (pdd), and asperger's syndrome. the investigators hope that information gained from this study will lead to new ways of diagnosing and treating asds.

participation generally takes less than 2 hours to complete and travel to children's hospital boston is not required. participants are asked some questions about their medical and family history. the investigators also request permission to review medical records related to the asd diagnosis. finally, the investigators obtain a small blood or saliva sample in order to search for genes that may be important in understanding asd. the investigators can arrange for the blood draw through a participant's physician or a clinical laboratory and saliva samples can be obtained through the mail. the study questions are answered via telephone or mailed questionnaires. there is no cost to participate.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of an autism spectrum disorder (autism, pervasive developmental disorder (pdd), or asperger's syndrome) * age \> 18 months exclusion criteria: * do not have the diagnosis of an asd * participation in the "phenotypic and genetic risk factors in asd" study at boston children's hospital.

Keywords: autism asperger's syndrome asperger syndrome autistic disorder autism spectrum disorder pervasive developmental disorders pervasive developmental disorder-not otherwise specified child development disorders, pervasive pdd-nos
diffusion tensor (magnetic resonance) imaging and tractography in herniation of the cervical spine

Conditions: Cervical Spine Herniation

Summary: this is an investigator-iniated pilot study to determine if mri with diffusion tensor imaging (dti) and tractography will yield useful information in patients suspected of having cervical spine disc herniation to provide imaging confirmation of whether or not disease is progressing and to assess response to treatment (regardless of treatment provided).

conventional mri (magnetic resonance imaging) is used to confirm disc herniation of the cervical spine. symptoms of the condition can change before they can be seen by conventional mr images. therefore, very little gross change can be seen by conventional mri even after 6 weeks of treatment, either medical or surgical. this study will investigate whether newer mri techniques, diffusion tensor imaging (dti) and tractography, are useful in demonstrating gross changes or assessing response to treatment. consenting patients referred for clinically indicated cervical spine mri by their treating physicians to confirm cervical disc herniation will receive an additional mri sequence, diffusion tensor imaging. this will provide a baseline. the dti sequence will add five minutes to the procedure. participants will return at 6 weeks for a follow up mri of the cervical spine to include dti and tractography. participants will be asked to complete an anonymized questionnaire at enrollment and at follow up to provide information regarding their condition. mri is a non-invasive diagnostic study of minimal risk which uses magnets instead of ionizing radiation to acquire images. the images are then assembled by computer. diffusion tensor imaging (dti) uses water diffusion to visualize structures in the brain and nervous system. tractography is performed using dti and computer post-processing to track the fiber bundles which exist in the brain and spinal cord and visualize them as two and three dimensional images. both techniques allow radiologists to detect abnormalities, in this case, cervical spine disc herniation. the follow up studies will be compared to the baseline studies to determine which demonstrates the highest sensitivity and specificity in identifying cervical spine abnormalities in general and cervical spine herniation in particular.

Eligibility criteria:
inclusion criteria: * patients suspected of having cervical spine herniation. exclusion criteria: * patients not suspected of having cervical spine herniation. * patients in which mri is contraindicated (patients with embedded metallic objects, including pacemakers, surgical clips, spinal cord stimulators, or prosthetic heart valves.) * patients requiring general anesthesia or conscious sedation--sedation would increase risk to participants.

Keywords: cervical spine herniation mri cervical spine diffusion tensor imaging cervical spine
the effects of tele-yoga in ankylosing spondylitis patients

Conditions: Ankylosing Spondylitis; Yoga

Summary: the aim of this study is to investigate the effect of tele-yoga on functional level, disease activity, spinal mobility, balance, aerobic capacity, sleep quality, anxiety, depression, stress, mindfulness and quality of life in patients with ankylosing spondylitis

yoga is an ancient discipline that emerged in india thousands of years ago, designed to bring balance and health to the physical, mental, emotional and spiritual dimensions of the individual.due to its therapeutic effects, yoga can be considered as an alternative approach for those with rheumatic disease. because of covid-19, which has changed the world and the lifestyle of people, tele-yoga practice can be considered as an alternative instead of traditional face-to-face yoga classes. the use of online platforms provides a good environment for yoga training at home. the aim of this study is to investigate the effects of tele-yoga on functional level, disease activity, spinal mobility, balance, sleep quality, depression, mindfulness and quality of life in patients with ankylosing spondylitis. 60 as patients who meet the inclusion criteria will be assigned to the tele-yoga or waiting list control group by the block randomization method. patients in the tele-yoga group will participate in tele-yoga sessions with a maximum of 5 people in each group by video-conference method for 8 weeks, 3 days a week. assessments will perform just before starting to study and after the 8-week tele-yoga program. patients in the waiting list control group will be asked to continue their normal physical activities during the 8-week study, not to start a new exercise program, and to report any changes in the drug or dosage used. control group's assessments will be performed when they are included in the study and at the end of 8 weeks. after these assessments, patients who wish will participate in the tele-yoga program.

Eligibility criteria:
inclusion criteria: * ankylosing spondylitis(as) patients diagnosed according to modified new york criteria * to be volunteer * to have the necessary equipment to provide internet access and connection exclusion criteria: * presence of systemic, orthopedic neurological or cognitive disease other than ankylosing spondylitis * regular exercise in the last 3 months * pregnancy * not attending 4 consecutive yoga sessions * changing the drug during the study * has an acute attack during the study

Keywords: ankylosing spondylitis yoga
the weigh forward, financial incentives for maintenance of weight loss

Conditions: Obesity

Summary: this study aims to evaluate the effectiveness of financial incentives in improving and maintaining weight loss.

the study will evaluate the effectiveness of financial incentives in improving maintenance of weight loss. the investigators propose a 2-arm randomized controlled trial in which 258 participants who lose at least 5 kgs in a weight loss program will be randomized to one of the following: 1) daily weigh-ins and weekly feedback, 2) daily weigh-ins,weekly feedback, and a weekly escalating lottery-based financial incentive. study participants will be obese volunteers recruited from a major community-based weight loss program (weight watchers), who have lost at least 5kg during the 4-6 months prior to enrolling in the study. upon enrollment, these participants will have an active online membership with weight watchers. among these participants, the following will be assessed: 1. assess the effectiveness of escalating lottery rewards, relative to the control group, on maintenance of weight loss over the ensuing 6 months (phase i); 2.the degree to which weight loss is maintained in the intervention group relative to usual care during the 6 months following the cessation of the interventions (phase ii). during phase i, incentives will be provided to some study participants (escalating lottery arm) for the first 6 months and participants will be followed for 6 more months to examine effects following cessation of incentives.

Eligibility criteria:
inclusion criteria: * adults age 30-80 * bmi between 30 and 45 prior to starting weight watchers * have a documented weight loss of at least 5kg in the past 4-6 months before enrolling * stable health * have an online weight watchers membership exclusion criteria: * substance abuse * bulimia nervosa or related behaviors * pregnancy or breast feeding * medical contraindications to counseling about diet, physical activity, or weight reduction * unstable mental illness * screen positive for pathological gambling on the basis of the 10 item dsm-iv criteria (excluded if meets 5 or more criteria) * individuals unable to read consent forms or fill out surveys in english
characteristic and evolution of an atypical ige-mediated cow milk allergy form with hands and feet angio-oedema

Conditions: Milk Allergy

Summary: cow milk allergy is one of the most frequent food allergy among children. cow milk protein's avoidance is needed until spontaneous recovery during the two first years of life. a atypical clinical form with angio-oedema of hands and feet which is associated with high rate of lactoserum's ige might be a hope of an earlier recovery.

cow milk allergy is one of the most frequent pediatric food allergy and occurs during the first months of life. it is due to an inappropriate reaction of immune system against the human body. its treatment is the avoidance of the cow milk proteins. its spontaneous recovery occurs mostly during the first years of life with the decreasing of the specific ige and the clinical tolerance to cow milk proteins. two shorts cas reports (3 and 5 patients) have described a clinical form of ige-mediated cow milk allergy with angio-oedema of hands and feet. this clinical form is associated with more increasing of specific ige against lactoserum proteins than caseine's. however it has been showed that casein is a marker of cow milk allergy persistence. it might be possible that this atypical form of cow milk allergy progresses favorably towards a restoration of tolerance earlier than the clinical form without angio-oedema of the extremities

Eligibility criteria:
inclusion criteria: * patients with a concordant history of ige-mediated cma (skin reaction within the next hours of cow milk proteins intake, regression of symptoms with avoidance of cow milk, +/- recurrence of identical symptoms when readministration) * patients with documented positive awareness markers (skin test and/or specific ige \> 0,1 kilo units of allergen-specific ige per liter (kua/l )) * patient followed at the pediatric allergology consultation at the pediatric hospitals of nice exclusion criteria: * patients without ige specific performed in the first month after the reaction * patients who have had only 1 documented specific ige test
inflammatory index as a predictor for endometrial cancer: an observational study

Conditions: Endometrial Neoplasms; Inflammatory Response

Summary: it is a prospective observational trial. primary goal is identification of an association between alteration of systemic inflammation indices, such as neutrophil-to-lymphocyte ratio (nlr), platelet-t- lymphocyte ratio (plr), lymphocyte-to-monocyte ratio (mrl) and patients risk classification according to european guidelines. the population is represented by all women being admitted to the gynecology ward, through emergency, who are affected by endometrial cancer. participants will undergo surgery, and freely express their consent to participate in the study.

surgical treatment for endometrial cancer is class a radical hysterectomy according to querleu-morrow and bilateral adnexectomy with systematic pelvic lymphadenectomy. that allows the choice of adjuvant treatment, basing on anatomopathological risk information. despite the standardization of adjuvant treatments, survival curves are heterogeneous in patients' responses. that is why european guide-lines have proposed a stratification of patients basing on oncological risk and molecular data (microsatellite instability, aberrant p53, pole gene mutation). the investigators want to identify additional parameters to better define risk profiles. systemic inflammation indices such as neutrophil-to-lymphocyte ratio (nlr), platelet-to-lymphocyte ratio (plr) and lymphocyte-to-monocyte ratio (lmr) have shown prognostic value in several inflammatory conditions and solid tumors. therefore, the investigators have decided to explore their role also in recently diagnosed endometrial cancers, to find correlations with lymphovascular space invasion (lvsi), myometrial infiltration, histotype, and therefore with oncological risk classification. it is a prospective observational trial. primary goal is identification of an association between alteration of systemic inflammation indices, such as neutrophil-to-lymphocyte ratio (nlr), platelet-t- lymphocyte ratio (plr), lymphocyte-to-monocyte ratio (mrl) and patients risk classification according to european guidelines. the population is represented by all women being admitted to the gynecology ward, through emergency, who are affected by endometrial cancer. participants will undergo surgery, and freely express their consent to participate in the study.

Eligibility criteria:
inclusion criteria: * patients histologically diagnosed with endometrial cancer. * patients undergoing surgical staging of the disease. * patients undergoing full-body ct-scan 30 days before enrollment. * at least 18-year-old patients. exclusion criteria: * unfit to plead. * patients with chronic inflammatory diseases (ibds; rheumatic conditions). * synchronous tumors or cancer diagnosis in the previous 3 years. * patients undergoing steroid therapy in the last 30 days prior to recruitment
alpha radiation emitters device for the treatment of squamous cell carcinoma

Conditions: Squamous Cell Carcinoma

Summary: a unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device.

this will be a prospective, first in man, controlled study, assessing the safety and efficacy of diffusing alpha emitters radiation therapy (dart) delivered through radioactive seeds inserted into the tumor. this approach combines the advantages of local intratumoral irradiation of the tumor, as used in conventional brachytherapy, with the power of the alpha radiation emitting atoms, that will be introduced in quantities considerably lower than radiation therapy already used in patients. lesions with histopathological diagnosis of squamous cell carcinoma will be studied. reduction in tumor size 30 days after dart insertion will be assessed. safety will be assessed by the incidence, severity and frequency of all adverse events (ae).

Eligibility criteria:
inclusion criteria: 1. histopathological confirmation of squamous cell carcinoma. 2. tumor size ≤ 5 centimeters in the longest diameter. 3. age over 18. 4. women of childbearing potential will have evidence of negative pregnancy test. 5. life expectancy of more than 6 months. 6. performance status 2 (ecog scale) or less. 7. signed informed consent form. exclusion criteria: 1. tumor maximal diameter \> 5 centimeters. 2. tumor of keratoacanthoma histology. 3. performance status ≥ 3 (ecog scale). 4. patients with moribund diseases, autoimmune diseases or vasculitis. 5. patients under immunosuppressive and/or corticosteroid treatment. 6. volunteers that participated in other studies in the past 30 days.

Keywords: squamous cell carcinoma alpha emitting radiation skin cancer carcinoma, squamous hnscc
erector spinae plane block (espb) versus quadratus lumborum block (qlb) for postoperative analgesia after caesarean section

Conditions: Pain, Post Operative; Cesarean Section Complications; Anesthesia, Local; Obstetric Anesthesia Problems

Summary: management of pain after caesarean section represents an important anesthesiologic issue, since it is often suboptimal, leading to delayed functional recovery and chronic pain. currently, the postoperative analgesic strategy mostly relies on intrathecal morphine (itm) and multimodal analgesic regimen. recently, the need for alterative opioid sparing techniques is emerging. paraspinal fascial plane blocks, as quadratus lumborum block (qlb) and erector spinae plane block (espb) performed at t9 level, have therefore been proposed as alternatives to itm, because of their demonstrated effect on visceral and somatic pain. the aim of the study is to assess the efficacy, the feasibility and safety of bilateral espb compared to bilateral qlb for the management of postoperative pain after ceasarean section conducted under spinal anesthesia without itm.


Eligibility criteria:
inclusion criteria: - patients asa 2 with normal singleton pregnancy, scheduled for elective caesarean section without intrathecal morphine, who underwent bilateral espb at the end of surgery an who gave informed consent to data collection. exclusion criteria: * contraindications to spinal anesthesia; * contraindications to or a history of opioid dependence; * allergy to local anesthetics, acetaminophen, nsaids * inability to understand pain assessment scales or to use patient controlled analgesia (pca) pump; * patient refusal.