Kornimate/medical-research-clean huggingface dataset:
effects of aromatherapy massage in menopausal women with knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: in this study, the effects of 4-week aromatherapy massage on pain, functionality, sleep quality and menopausal symptoms will be examined in individuals diagnosed with knee osteoarthritis during menopause.

the aim of this study is to investigate the effect of aromatherapy massage performed with bergamot oil for 4 weeks on pain, function, sleep and menopausal symptoms in menopausal women with knee osteoarthritis. participants will be randomly divided into 3 groups as bergamot, placebo and control. in addition to the conventional treatment, the bergamot group will receive 2 sessions of bergamot oil per week for 4 weeks, and the placebo group will be massaged with 2 sessions of sweet almond oil for 4 weeks. the control group will continue conventional treatment for 4 weeks. all assessments will be performed before starting treatment and at the end of 4 weeks of treatment. participants' pain will be evaluated by vas, functions by womac, sleep quality by psqi, menopausal symptoms by menopause symptoms evaluation scale. at the end of the study, the satisfaction of the participants will be evaluated with vas.

Eligibility criteria:
inclusion criteria: * being between the ages of 40-65, * having entered the menopause, * being diagnosed with knee oa, * being at the level of oa 2-3, * having pain at rest in the knee vas ≥ 4. exclusion criteria: * any knee surgery * known allergies to the oils to be used
the proteomic study and early intervention study of carotid unstable plaque

Conditions: Protein; Disease; Carotid Artery Plaque; Traditional Chinese Medicine

Summary: a study on the prediction model of carotid unstable plaque protein and its early intervention. protein antibody chip was used to detect the remaining biological samples, and patients with carotid artery unstable plaque with stroke risk were selected for interventional clinical trials. the selected patients were randomly divided into 3 groups, which were treated with zhu's wenban formula (tcm compound granules), qushi formula (tcm compound granules) and placebo for 6 months, respectively. the size and number of carotid artery unstable plaques before and after 6 months were observed, and the occurrence of adverse reactions during the intervention period was observed.


Eligibility criteria:
inclusion criteria: * wet syndrome scale assessment is consistent with wet syndrome diagnosis; * carotid color ultrasound indicated carotid artery unstable plaque. * protein chip analysis determined that the patients were at high risk of stroke * signing informed consent exclusion criteria: * carotid artery stenosis rate ≥50%; * a definite or suspected diagnosis of vasculitis; * accompanied by infection, tumor, heart, liver and renal insufficiency (liver and * kidney function more than twice the upper limit of normal value, cardiac function grade greater than or equal to 2); * patients with acute stroke or complicated with acute myocardial infarction and unstable angina pectoris; * pregnant or lactating women; * a prior known allergy to the test drug or the test drug ingredient.

Keywords: traditional chinese medicine proteomic study carotid atherosclerosis plaques
impact of sending an sms on the rate of telephone responses of subjects contacted 3 months after the suicidal act

Conditions: Suicide, Attempted

Summary: the objective of this controlled, randomized, monocentric study is to compare the response rate of the call at 3 months of the groups with or without short message service (sms) 48 hours before, for the subjects having benefited from the device "vigilans lorraine". the secondary objectives will be to appreciate the satisfaction of the subjects towards the sending of the sms as well as to compare the delay of suicidal recidivism according to whether the subjects answered or not to the call of evaluation at 3 months of the passage to the act the main question it aims to answer is: what impact, on the rate of successful calls, could sending a text message 48 hours before the 3-month evaluation phone call have on subjects benefiting from the vigilans device? the participants will be divided into 2 groups: * 1st group: sms sent 48 hours before the 3-month evaluation call planned in the framework of the "vigilans lorraine" program. * 2nd group (control): evaluation call at 3 months planned within the framework of the "vigilans lorraine" system, not preceded by an sms 48 hours before. the desired effect was an increase in the percentage of successful calls at 3 months, allowing for possible evaluations at 3 months in order to identify, evaluate and accompany subjects still in a suicidal crisis and thus avoid a recurrence of the act and thus a suicide.


Eligibility criteria:
inclusion criteria: * having made a suicide attempt (first-time suicide or not) * hosted at the central hospital of nancy * included in the "vigilans lorraine" monitoring system * not presenting criteria for non-inclusion in the "vigilans lorraine" system, namely: * guardianship * held * dementia * not speaking french * subject having received information relating to the progress of the evarest 3 study and having given their consent to participate * subject affiliated or entitled to a social security scheme exclusion criteria: * subject without mobile phone * participation in another interventional study on the prevention of suicidal recidivism * subject under curatorship who was not assisted by his curator to give his consent to participate

Keywords: suicide attempt prevention standby device
influence of changes in food group variety on food cravings, energy intake, and weight loss after bariatric surgery

Conditions: Obese

Summary: the purpose of this study is to find out if there is any change in diet on food cravings and weight loss in the 12 months following bariatric surgery.

research suggests that satiation processes in obese patients may be impaired, possibly resulting in excessive energy intake and poorer weight loss outcomes. one factor that may contribute to disruption of satiation processes and related overconsumption is dietary variety. additionally, food cravings for restricted foods are believed to contribute to poor compliance to diets, and in controlled feeding studies, food cravings are the most frequently provided reason for poor dietary adherence. interestingly, several investigations have found that cravings decrease when individuals follow a very-low-calorie or monotonous diet (9-11). thus, reductions in the variety of the diet may also reduce food cravings, and assist in dietary adherence. it is also possible that the type of surgical procedure performed may influence changes in dietary variety, and consequently food cravings. to date, few studies have analyzed bariatric surgery patients' selection of foods within specific food groups and no study has examined the variety of foods consumed within food groups. changes in food group variety which facilitate improvements in regulation of energy intake and body weight among obese individuals after behavioral weight loss may have a similar impact in patients who undergo bariatric surgery. additionally, no studies have examined the relationship between changes in dietary variety and food cravings, and how these factors may be related to weight loss outcomes in any population. primary objectives: to examine by surgery type(roux-en-y gastric bypass \[rygb\], laparoscopic adjustable gastric banding \[lagb\], vertical sleeve gastrectomy \[vsg\]) 1. changes in dietary variety from pre- to post-bariatric surgery at 3, 6, and 12-months 2. changes in variety of high-energy-dense foods and changes in cravings of high-energy-dense foods at 3, 6, and 12 months and 3. changes in variety of high-energy-dense and low-energy-dense foods and changes in energy intake and weight loss at 3, 6, and 12 months.

Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * bariatric surgery occurring within 3-6 months exclusion criteria: * intend to move outside of the metropolitan area within the time frame of the investigation. * are pregnant, lactating, less than 6 months post-partum, or plan to become pregnant during the time frame of the investigation.
efficacy, safety and recurrence after cold-emr plus apc for large colonic lesions

Conditions: Colonic Disease

Summary: this prospective observational study aims to evaluate the efficacy, safety and recurrence of cold-snaring for large colonic lesions combined with argon plasma coagulation of the resection bed.


Eligibility criteria:
inclusion criteria: * all patients aged ≧ 18 years undergoing colonoscopy for any indication (screening, anemia, surveillance, or scheduled to undergo endoscopic mucosal resection) * lesions of 20 mm and larger. * all colonic lesions removed using cold-emr technique, presenting both adenomatous (kudo iiil/iiis pit pattern) * patients who were able to provide written informed consent exclusion criteria: * suspected lesions for submucosal invasion (e.g., kudo v or paris 0-iia-iic with non-granular surface) * lesions with a wide paris 0-is component (\>10mm) that could increase the risk of submucosal invasion and could limit the mechanical cutting of the snare * pedunculated polyps * active/quiescent colitis * rectal lesions * residual or recurrent adenoma after endoscopic mucosal resection
clinical study of comorbidities of attention deficit hyperactivity in children and adolescents.

Conditions: Attention Deficit Hyperactivity Disorder

Summary: determine the frequency of psychiatric and neurological comorbidities in children and adolescence diagnosed with adhd.

adhd is a common neurodevelopmental disorder characterized by hyperactivity, impulsivity, and inattention .adhd is more often a complex disorder with a high rate of associated co-morbid conditions. co-morbid conditions are prevalent among people with adhd and increase its burden and complexity of management.children with adhd are at a higher risk than children without adhd for developing other psychiatric disorders .motor skill problems and neurological soft signs are found in many neuropsychiatric conditions .nss have been associated with inattention and behaviour difficulties for decades. some researchers argue that these signs should be included in the diagnosis of adhd .

Eligibility criteria:
inclusion criteria: * age: 6-17 years. * sex: both sexes will be included in the study. * iq≥70. exclusion criteria: * age: less than 6 years or more than 17 years. * iq\<70. * patients with major neurological deficits, cerebral palsy and uncontrolled epilepsy. * patients with major psychiatric disorders e.g schizophrenia spectrum disorder. * patient who refusing to participate in the study or their caregiver refusing to give informed consent.

Keywords: adhd,comorbidities
project step: evaluating deposit contracts and daily feedback to promote walking in overweight and obese adults

Conditions: Physical Activity; Sedentary Lifestyle; Obesity; Overweight

Summary: the purpose of this study is to test whether deposit contracts, wherein individuals invest their own money with the study to serve as the incentive, with or without daily feedback about progress help individuals to increase step counts and more often meet a step goal compared to self-monitoring only.

approximately 68% of adults are overweight or obese, which is associated with increased risk for health conditions, including cardiovascular disease, type 2 diabetes, and cancer. these individuals are more often sedentary than the general population, which compounds the risk for these same conditions. while the benefits of engaging in physical activity are well-established, few individuals are able to successfully increase activity to recommended levels. existing intervention programs, often derived from theories such as social cognitive theory or related theories, have had limited success. behavioral economics offers a promising alternative, suggesting that engagement in any behavior is based on the maximizing utility and happiness. interventions based on this theory aim to increase the immediate benefit of engaging in physical activity, often using a financial incentive. this study will last for 16 weeks. each participant will invest $42 with the study, and be exposed to to each of three interventions. all participants will have the use of a fitbit for ongoing self-monitoring and a step-count goal of 10,000 steps per day. in one condition, these will be the only interventions you receive. in one condition, you will receive a monetary consequence for meeting or not meeting the goal. each day during the incentive conditions, you will be eligible to lose $0.75 of your own money for not meeting the goal, or to earn back $0.75 of your money plus $0.75 from the study (i.e., a total of $1.50) for meeting the goal. in the third condition, you will have daily feedback mid-afternoon about your distance from the goal and the money you stand to gain or lose. you will be made aware of what condition you are in.

Eligibility criteria:
inclusion criteria: * 25 kg/m2 ≤ bmi ≤ 45 kg/m2 * age 18-70 * currently inactive (engages in less than 6,000 steps/day on at least 4 of 7 days per week, confirmed by fitbit at baseline) * able to engage in moderate amount of walking * able to receive email/text messages from study staff exclusion criteria: - medical or psychiatric conditions that would make it difficult to comply with study protocols
detection of topographic residual acuity in patients with age related macular degeneration

Conditions: Age-Related Macular Degeneration

Summary: standard perimetry provides information on topographical retinal sensitivity to light stimuli, however the said locus is not necessarily the preferred locus for fixation. standard perimetry could also be used as a way for macular scotoma mapping, indirectly showing the fixation locus. topographic acuity at the preferred retinal locus can be determined if correlation between loci with high sensitivity, eccentric fixation loci and potential visual acuity measurements are correlated. purpose of the study: determination of visual acuity at preferred retinal locus in low vision patients with armd using eye standard automated and computerized perimetry methods.


Eligibility criteria:
inclusion criteria: * amd with documented pathology * low vision both eyes * bcva 20/50-20/400 in best eye exclusion criteria: * cognitive impairment * other retinal pathology * previous retinal surgery * significant media opacity

Keywords: age-related macular degeneration preferred retinal locus macular perimetry
estrogen hormone protocol

Conditions: Alzheimer Disease

Summary: estrogen is a hormone that is dominant in the female reproductive system. in women, most estrogen is produced by the ovaries. men produce estrogen by converting testosterone into estrogen. because this hormone also has many beneficial effects on brain cells, it currently is being studied as a treatment for alzheimer's disease. the enzyme that forms the neurotransmitter acetylcholine is promoted in the presence of estrogen. several very small clinical studies have demonstrated improvement in cognitive function and mood measures in women with alzheimer's disease who take estrogen.


Eligibility criteria:
inclusion criteria: * women with a diagnosis of alzheimer's disease who currently are not taking estrogen replacement therapy, who have had a hysterectomy, and who are in stable general health. exclusion criteria: * patients with an uncontrolled health problem, such as untreated high blood pressure or thyroid disease.

Keywords: alzheimer's disease estrogen
the physical activity post myocardial infarction swedeheart prospective cohort study

Conditions: Myocardial Infarction

Summary: the association between objectively measured physical activity intensities (light, moderate and vigorous), sedentary time and clinical outcomes has not been clarified in patients after a myocardial infarction. the overall objective of the study is to explore associations between accelerometer measured physical activity and clinical outcomes after a myocardial infarction. moreover, the association between changes in physical activity and outcomes will be assessed.

it is estimated to include 4000 patients with myocardial infarction during 2 years. patients will wear the accelerometer for 7 days at follow-up visits (2 months and 1 year) after discharge. the investigators will examine the dose-response relations of several exposure variables from the accelerometer measurements with the outcomes.

Eligibility criteria:
inclusion criteria: * signed informed consent * diagnosis of a type 1 myocardial infarction registered in swedeheart * age 18-79 years at discharge from hospital * attending the first visit in the cardiac rehabilitation (cr) registry sephia (2 months after discharge) exclusion criteria: * inability to understand swedish * non-ambulatory * any mental condition that may interfere with the possibility for the patient to comply with the study protocol

Keywords: physical activity accelerometer registry
study on the correlation between tracheotomy tip pressure and esophageal pressure in patients weaned from tracheotomy

Conditions: Respiratory Distress Syndrome (RDS); Respiratory Ilness

Summary: whether the correlation between gas incision tip pressure fluctuations (δptt) and esophageal pressure fluctuations (δpes) is a potential measure of spontaneous respiratory effort in patients undergoing gas incision offline.


Eligibility criteria:
inclusion criteria: * adult patients (≥18 years old), regardless of gender * tracheostomized patients with spontaneous breathing; * weaning criteria: under the condition of mask oxygen inhalation at 5l/min, spo2 \> 94%, pao2/fio2 \> 150 - 200. * the patient has stable hemodynamics and ph ≥ 7.32; * agree to participate in this trial and sign the informed consent form. exclusion criteria: * patients with contraindications for esophageal catheter insertion and unable to monitor esophageal pressure; * patients with bleeding risks: severe coagulation disorders, esophageal varices； * local injuries: basilar skull fracture, maxillofacial fracture; * pregnant women; * patients considered not suitable by the researcher.

Keywords: esophageal-pressure tracheotomy tip pressure
clinical study to compare the efficacy and safety of ponesimod to placebo in subjects with active relapsing multiple sclerosis who are treated with dimethyl fumarate (tecfidera®)

Conditions: Multiple Sclerosis

Summary: this clinical study compares the efficacy, safety, and tolerability of therapy with ponesimod vs placebo in subjects with active rms who are treated with dmf (tecfidera®).

the study will assess the efficacy, safety, and tolerability of add-on therapy with ponesimod 20 mg vs placebo in adult participants with active relapsing multiple sclerosis (rms) who are treated with dimethyl fumarate (dmf). approximately 600 participants who have been receiving dmf for at least 6 months will be randomized in a 1:1 ratio to ponesimod 20 mg or placebo. the study consists of the following study periods: pre-randomization period; treatment period; post-treatment observation period. the study includes one ponesimod treatment arm at the maintenance dose of 20 mg o.d. corresponding to the optimal dose when used as monotherapy based on the phase 2 dose-finding trial and its ongoing extension. the study includes a placebo comparator arm, but all patients will remain on dmf background therapy throughout the study. moreover, participants who experience a confirmed relapse or an event of 24-week confirmed disability accumulation (dmf) while on study drug will have the option to switch to an alternative treatment. the treatment period has a variable duration from a minimum of 60 weeks (for the last subject randomized) to a maximum of 156 weeks for the first subjects randomized in the trial and includes a gradual up-titration of ponesimod from a 2 mg starting dose to a 20 mg maintenance dose over a period of 14 days. the total duration of the study will be approximately up to 167 weeks.

Eligibility criteria:
inclusion criteria: * signed informed consent prior to initiation of any study-mandated procedure. * women of childbearing potential must have a negative pregnancy test and use reliable methods of contraception * presenting with a diagnosis of ms as defined by the revised (2010) mcdonald diagnostic criteria for ms with relapsing course from onset (i.e., relapsing-remitting multiple sclerosis (rrms), or secondary progressive multiple sclerosis (spms) with superimposed relapses). * ongoing treatment with dmf for at least 6 months prior to screening * active disease after at least 3 months of dmf treatment * ambulatory and with an edss score between 0 and 6.0 (inclusive). exclusion criteria: * lactating or pregnant women and women intending to become pregnant during the study. * presenting with a diagnosis of ms with progressive course from onset (i.e., primary progressive ms or progressive relapsing ms). * evidence of a relapse of ms with onset within 30 days prior to baseline edss assessment. * any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol.