Kornimate/medical-research-clean huggingface dataset:
thorough flushing strategy during colonoscopy examination

Conditions: Colonoscopy

Summary: the investigators plan to adopt a thorough flushing strategy when withdrawing the endoscope, and have zero tolerance for the liquid and foam in the intestinal lumen. observe and compare the impact of this strategy with traditional limited degree suction methods on the results of colonoscopy. the research group and the control group respectively adopted a thorough flushing strategy and a limited flushing strategy, and compared the total time of colonoscopy examination, the time of withdrawal, the detection rate of polyps, the detection rate of small polyps, and the amount of flushing fluid between the two groups. analyze the value of thorough flushing strategy for the efficiency and quality of colonoscopy examination.

most physicians do not adopt a strategy of complete suction of fluid from the intestinal lumen during colonoscopy. there are both concerns about the time required for colonoscopy and the possibility of inability to thorough cleannig up. some endoscopists believe that the visual field for partial cleaning of fecal water is acceptable and does not affect observation. this study aims to make an observation and comparison based on the existing problems mentioned above. with the help of direct water injection system, the investigators plan to adopt a thorough flushing strategy when withdrawing the endoscope, and have zero tolerance for the liquid and foam in the intestinal lumen. observe and compare the impact of this strategy with traditional limited degree suction methods on the results of colonoscopy. the research group and the control group respectively adopted a thorough flushing strategy and a limited flushing strategy, and compared the total time of colonoscopy examination, the time of withdrawal, the detection rate of polyps, the detection rate of small polyps, and the amount of flushing fluid between the two groups. analyze the value of thorough flushing strategy for the efficiency and quality of colonoscopy examination.

Eligibility criteria:
inclusion criteria: * people without contraindications for colonoscopy exclusion criteria: * patients diagnosed with colon polyps

Keywords: colonoscopy, quality, polyps
comparing two linkage-to-care models for latinx immigrant patients : a pilot comparative clinical effectiveness trial

Conditions: Chronic Disease

Summary: the goal of this randomized clinical comparative effectiveness trail is to compare the effects of patient navigator models on follow-up care in latinx and indigenous mexican immigrant patient populations. the main question\[s\] it aims to answer \[is/are\]: * participants randomized to pn-chw compared to the pn-cs model will be more likely to follow through with follow-up care referrals * trust will be a driving factor as to why pn-chw will be a more effective intervention for the patient population. researchers will compare patients in a patient navigator community health worker (pn-chw) intervention to those in a patient navigator clinical staff (pn-cs) intervention to see which model of linkage to care is more effective for follow-up care in the patient population. participants will be asked to: * complete a baseline survey about healthcare access * receive calls and text messages from either a chw or clinical staff * complete a follow up survey

the research project will be conducted at a free clinic that serves a primarily spanish-speaking latinx patient population in the inland southern california region. patients in this study will be randomized to one of two intervention arms: arm 1: pn model delivered by chws/promotoras and arm 2: pn model delivered by clinic staff. chws who live in the region and work at the free clinic will deliver the pn model for arm 1 participants. chws have a detailed knowledge of local health resources, as well as lived experience of the barriers patients in their community face when accessing healthcare services. medical students who are volunteer clinic staff will deliver the pn model for arm 2 participants. medical students are the doctors in training who provide primary care services to patients at the cvfc under the supervision of well-established physicians. baseline data and follow-up data at 12 weeks will be collected along with qualitative interviews with patients in both arms of the study.

Eligibility criteria:
inclusion criteria: * 1) live in the coachella valley, 2) 18 or older, 3) household income less than or equal to or below 200% of federal poverty guidelines, 4) do not currently have health insurance, and 5) have access to a telephone. exclusion criteria: * do not speak english, spanish or purépecha (an indigenous dialect spoken among the purépecha of mexico).
dual-task training using virtual reality

Conditions: Stroke

Summary: the purpose of the study was to investigate the feasibility of using a virtual reality- based dual task training of upper extremity tracking while treadmill-walking, to improve walking and balance performance in post stroke survivors


Eligibility criteria:
inclusion criteria: * with hemiplegia after a stroke for at least a year since the incident. * range age 40-80. * without medication or with stabilized medication. * use ankle-foot orthosis or no splint at all. exclusion criteria: * severe cardiac problems * a score less than 25 in the mini-mental test. * fractures or severe orthopedic limitations that do not allow for training, and which have occurred over the last six months. * more than three falls in the past year before participating in the study
vestibular system in migrainous vertigo patients

Conditions: Migraine Disorders; Migraine Variant; Episodic Recurrent Vertigo

Summary: do migrainous vertigo patients have more pathology in their vestibular system than migraine patients without vertigo? the aim of this study is to compare the vestibular system of migraine patients with and without vertigo in the symptom-free period by vestibular function tests, videonystagmography, vestibular evoked myogenic potentials, and subjective visual vertical.


Eligibility criteria:
inclusion criteria: * migraine according to ihs criteria * migrainous vertigo according to the neuhauser-criteria exclusion criteria: * no history of other neurological, vestibular, opthalmologic and ent disorders * no medications that could possibly influence test results * intact hearing measured by audiometry * pregnancy

Keywords: migraine migrainous vertigo vestibular evoked myogenic potentials vestibular function test vestibular disorders
efficacy of melatonin, low-dose quetiapine, or placebo in patients with psychiatric disorders and comorbid insomnia

Conditions: Psychiatric Disorders; Insomnia

Summary: the goal of this investigator-initiated, randomized, blinded, 3-armed placebo-controlled, pragmatic, clinical superiority trial is to examine the efficacy of melatonin or low-dose quetiapine versus placebo for treatment of insomnia in patients with psychiatric disorders. the aims of the study are: * to examine the efficacy of melatonin or low-dose quetiapine versus placebo for treatment of insomnia * to examine how melatonin or low-dose quetiapine affects global symptom severity, sleep quality, psychosocial functioning and subjective well-being. participants will receive six weeks of treatment with either melatonin, quetiapine or placebo followed by a brief taper off.


Eligibility criteria:
inclusion criteria: * 16 to 64 years of age * icd-10 diagnosis of a current or previous mental or behavioral disorder (f20-f69, f84, f90-95) * for the diagnoses f84 and f90 a previous period of treatment with melatonin is required * for the 16-17 years old: non-pharmacological treatment options including sleep hygiene education, weighted blanket or other gravity products have been tested with insufficient effect * self-reported sleep difficulties at least three times per week in the preceding 3 months * insomnia severity index score ≥11 * women of childbearing potential: negative pregnancy test at baseline and use of highly effective contraception measures * informed consent exclusion criteria: * current treatment with melatonin or quetiapine * severe somatic comorbidity * bmi ≥ 35 kg/m2 * breastfeeding * alcohol and/or substance dependency within the last 3 months * inadequate danish language skills * not able to make an informed consent * increased cardiac risk as assessed by presence of cardiac risk factors, cardiac symptoms, or prolonged qt-interval at baseline ecg
phase 2 hypofractionation study using proton beam therapy for prostate adenocarcinoma

Conditions: Prostate Adenocarcinoma

Summary: phase 2 hypofractionation study usion proton beam therapy for prostate adenocarcinoma


Eligibility criteria:
inclusion criteria: biopsy proven prostate adenocarcinoma stage: t1-t2cn0m0 ecog performance status: 0-2 signed study specific informed consent prior to study entry exclusion criteria: postoperative residual or recurrent tumor evidence of distant metastases previous irradiation for the tumor in the same location adjuvant anti-androgenic hormonal therapy high risk group (nccn guide line)

Keywords: hpofractionation study using proton beam therapy
the efficacy of re-treatment with sulfadoxine-pyrimethamine in children

Conditions: Malaria, Falciparum

Summary: children participating in a study evaluating the efficacy of chloroquine and amodiaquine for the treatment of malaria will, if getting malaria during follow-up, be re-treated with sulfadoxine-pyrimethamine (sp) in accordance with the recommendations of the national malaria programme. to compare the actual efficacy of sp with that in 1995 - 1996 we, the investigators of the bandim health project, will visit these children once a week for 5 weeks. a finger prick blood sample will be collected for a malaria test. children with malaria during follow-up will be treated according to the guidelines of the bandim health centre.

the bandim health project studies the efficacy of different treatment regimens for malaria in children. if the included children during follow-up get malaria again they are, according to the recommendations of the national malaria programme, treated with sulfadoxine-pyrimethamine (sp). in 1995 - 1996 the efficacy of this re-treatment regimen was evaluated in the same area. to evaluate if treatment with sp is still efficient we want to follow children included in a study comparing treatment with chloroquine and amodiaquine having recrudescent malaria for 35 days following the re-treatment with sp. children with reappearing parasitaemia will be treated with sp. if accepting to participate in this study the children will be visited once a week and a capillary blood sample will be drawn. the blood sample taken on the day of reappearing parasitaemia in the chloroquine/amodiaquine study will be used as the day 0 blood sample in the sp-study. if the child gets malaria during the follow-up he will be treated according to the guidelines of the bandim health centre. all treatment during follow-up will be free.

Eligibility criteria:
inclusion criteria: * malaria symptoms plus positive malaria film * \> 20 parasites per 200 leukocytes * treatment failure in a study comparing chloroquine and amodiaquine * informed consent exclusion criteria: * stated allergy to sulfadoxine and/or pyrimethamine

Keywords: children malaria sulfadoxine-pyrimethamine guinea-bissau treatment
the effect of preoperative albumin administration on postoperative acute kidney injury in pediatric patients with hypoalbuminemia undergoing cardiac surgery

Conditions: Acute Kidney Injury; Pediatric Cardiac Surgery

Summary: the study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (aki) following cardiopulmonary bypass.


Eligibility criteria:
inclusion criteria: * pediatric patients under 7 years of age undergoing cardiac surgery with cardiopulmonary bypass * preoperative serum albumin level of 4.0 g/dl or lower exclusion criteria: * abnormal preoperative creatinine level * history of dialysis * liver dysfunction * diabetes * history of hypersensitivity to albumin * coagulation disorders
japan post-marketing surveillance for peficitinib to assess safety and effectiveness in the patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis (RA)

Summary: the objective of this study is to investigate the safety and effectiveness in routine clinical practice and actual clinical setting for all patients with rheumatoid arthritis (ra) treated with peficitinib.

this is a mandatory post-marketing surveillance (pms) requested by pharmaceuticals and medical devices agency (pmda) as a part of the japan-risk management plan (j-rmp).

Eligibility criteria:
inclusion criteria: * all patients with rheumatoid arthritis (ra) treated with peficitinib for the first time. exclusion criteria: * not applicable.

Keywords: post-marketing surveillance asp015k smyraf rheumatoid arthritis (ra) peficitinib
diabetes and depression text messaging intervention

Conditions: Diabetes; Depression; Physical Activity

Summary: the main aim of the "diabetes and mental health adaptive notification tracking and evaluation" trial (diamante) is to test a smartphone intervention that generates adaptive messaging, learning from daily patient data to personalize the timing and type of text-messages. we will compare the adaptive content to 1. a static messaging intervention with health management and educational messages and 2. a control condition that receives a weekly mood message. the primary outcomes for this aim will be improvements in physical activity at 6-month follow-up defined by daily step counts.

we utilized user-centered design (ucd) methods to iteratively develop the diamante content and text messaging system through three iterative phases of ucd with ten patients each (total n=30). the first phase consisted of 1.5-hour individual semi-structured interviews. findings from phase 1 were used to inform content and information delivery decisions of the final intervention, including selecting the thematic message categories and the design. in the second phase, patients tested out an early prototype of the mobile application through usability testing. patients tested the final diamante intervention including thematic message content and the application in the third, final ucd phase, in order to address any user-related issues prior to launching the randomized control trial. in the diamante randomized controlled trial, we aim to examine the effect of a smartphone app that uses reinforcement learning to predict the most effective messages for increasing physical activity. we will recruit 276 low-income minority patients with depression and diabetes within he san francisco health network. we will compare this intervention to static messages with health management content, and a control group that only receives a weekly mood message.

Eligibility criteria:
inclusion criteria: * hba1c (hemoglobin a1c) \> 7 * phq-8 (patient health questionnaire-8) \> 5 exclusion criteria: * high levels of physical activity (\>30 minutes of moderate to vigorous activity per day) * pregnancy * inability to exercise due to physical disability * serious mental illness * unable to read and write in english or spanish * plans to leave the country for extended periods of time during the trial
intraoperative monitoring (iom) patient registry

Conditions: Intraoperative Monitoring; Spinal Diseases

Summary: the primary objective of this study is to evaluate the rate of new or worsening neurologic deficits and/or radiculopathy following lumbar or cervical surgery in light of iom using neurological testing (motor and sensory) in the optimal management of the surgical patient.

prospective reports will be collected on approximately 10,000 patients undergoing lumbar or cervical spinal surgery using intraoperative monitoring. patients will be enrolled in registry after signing informed consent. data will be collected prior to surgery, during surgery, immediately following surgery and 4 to 6 weeks post surgery. the registry will serve as a database for surgeries using iom. specific outcome measures will be: neurological assessment, length of hospital stay, pain intensity, and complications.

Eligibility criteria:
inclusion criteria: * patients undergoing lumbar or cervical surgery * utilization of iom * understand and sign informed consent exclusion criteria: * there are no specific exclusion criteria

Keywords: iom ionm intraoperative monitoring intraoperative neuromonitoring spine lumbar cervical
efficacy and safety of magnólia nasal gel in the treatment of allergic rhinitis

Conditions: Allergic Rhinitis

Summary: the purpose of this study is to evaluate the efficacy and safety of magnólia nasal gel in the treatment of moderate-severe persistent or moderate-severe intermittent allergic rhinitis.


Eligibility criteria:
inclusion criteria: * ability to confirm voluntary participation and agree to all trial purposes by signing and dating the informed consent forms; * participants of both sexes, with age greater than or equal to 12 years; * clinical diagnosis of moderate-severe persistent or moderate-severe intermittent allergic rhinitis, according to the aria classification; * present the general status of rhinitis as moderate or severe; * total nasal symptom score greater than or equal to 6 points, with congestion and one or more of the other symptoms present (itching, runny nose, and sneezing) with a score greater than or equal to 2 at the screening visit; * present skin sensitization test to at least one aeroallergen; exclusion criteria: * any clinical and laboratory findings that, in the judgment of the investigator, may interfere with the safety of research participants; * history of alcohol abuse or illicit drug use; * participation in a clinical trial in the year before this study; * pregnancy or risk of pregnancy and lactating patients; * known hypersensitivity to the formula components used during the clinical trial; * participants who present other clinical forms of rhinitis, such as, but not restricted to medicated rhinitis, vasomotor and atrophic; * participants dependent on decongestants (nasal or oral) or receiving allergen-specific immunotherapy; * participants with suggestive signs of upper airways bacterial infection; * participants with grade ii or iii septum deviation and/or presence of nasal polyps or other conditions that lead to nasal obstruction; * concomitant chronic or intermittent use of decongestants, antihistamines, or corticosteroids by inhalation, oral, intramuscular, or intravenous; * concomitant use of potent topical corticosteroids.

Keywords: allergic rhinitis
atherosclerosis in familial hypercholesterolemia

Conditions: Familial Hypercholesterolemia

Summary: familial hypercholesterolemia (fh) is a common inherited disorder with a frequency of 1 in 500 in the uk. our aim is compare the carotid and coronary artery atherosclerosis in monogenic fh and polygenic hypercholesterolemia with means of a carotid ultrasound, a coronary ct angiogram and biochemical biomarkers.

familial hypercholesterolemia (fh) is a common inherited disorder with a frequency of 1 in 500 in the uk. previous studies showed that risk of heart attack in these patients is at least 50% higher in men and 30% higher in women compared to the general population as they have high blood cholesterol since birth. we propose to develop a screening model based on non-invasive visualisation of the heart blood vessels (coronary arteries) by ct scan, ultrasound of the neck vessels (carotid arteries) and blood tests to access the extend of cholesterol deposit in the blood vessels in these patients. participants with confirmed diagnosis of fh would be recruited from fh database registry at royal free hospital. they would have a ct coronary angiogram, an ultrasound of carotid arteries and a blood test. the study is divided into overlapping stages of recruitment and data collection and data analysis. if ct scan shows more than 70% obstruction in their coronary arteries, they would be offered a coronary angiogram and an intracoronary optical coherence tomography for assessment of their blood vessel blockage.

Eligibility criteria:
inclusion criteria: * the subjects must give written informed consent to participate in the study, male and female subjects ≥ 18 years old, documentation of clinical diagnosis of familial hypercholesterolemia exclusion criteria: * estimated gfr \<45, pregnant women, atrial fibrillation or unstable heart rate, established ischemic heart disease, previous percutaneous coronary investigations (pci) or coronary artery bypass surgery (cabg), known allergy to iodine contrast
dose-finding study of cp-675,206 and su011248 in patients with metastatic renal cell carcinoma

Conditions: Carcinoma, Renal Cell

Summary: this study will determine the highest tolerable dose of cp-675,206 when given in combination with su011248.


Eligibility criteria:
inclusion criteria: * histologically proven renal cell carcinoma with metastases * eastern cooperative oncology group (ecog) ps of 0 or 1 exclusion criteria: * prior treatment with more than one systemic therapy for metastatic renal cell carcinoma * history of or known brain metastases, spinal cord compression or carcinomatous meningitis, or new evidence of brain or leptomeningeal disease on screening computed axial tomography (ct) or magnetic resonance imaging (mri) scan