Kornimate/medical-research-clean huggingface dataset:
total hip replacement with the answer® hip stem and ranawat/burnstein® shell using simplex® or palacos® bone cement

Conditions: Osteoarthritis, Hip; Traumatic Arthritis of Hip

Summary: the purpose of this study is to document the clinical outcomes of several devices used in total hip replacement, including the answer® hip stem, the ranawat/burnstein® acetabular shell, and simplex® or palacos® bone cement.

the purpose of this study is to document the clinical outcomes of several devices used in total hip replacement, including the answer® hip stem, the ranawat/burnstein® acetabular shell, and simplex® or palacos® bone cement. it was desirable to see if there were any differences in the outcomes of two different types of bone cement in application.

Eligibility criteria:
inclusion criteria: * noninflammatory degenerative joint disease including osteoarthritis and avascular necrosis * rheumatoid arthritis * correction of functional deformity * treatment of non-union, femoral neck fracture, and trochanteric fractures of the proximal femur with head involvement, unmanageable using other techniques exclusion criteria: * infection, sepsis, and osteomyelitis
a study of venetoclax and amg 176 in patients with relapsed/refractory hematologic malignancies

Conditions: Acute Myeloid Leukemia; Non-Hodgkin's Lymphoma; Diffuse Large B-cell Lymphoma

Summary: this dose-escalation study evaluating the safety, pharmacokinetics and preliminary efficacy of venetoclax in combination with amg 176 in participants with relapsed or refractory acute myeloid leukemia (aml) and participants with non-hodgkin's lymphoma (nhl)/diffuse large b-cell lymphoma (dlbcl). this study will include a dose escalation phase to identify the maximum tolerated dose/recommended phase 2 dose (mtd/rptd) of venetoclax plus amg 176 as well as a dose expansion phase to confirm safety, explore efficacy, and confirm the suitability of the preliminary rptd.


Eligibility criteria:
inclusion criteria: * adequate kidney, liver and hematology values as described in the protocol. * diagnosis of relapsed or refractory (r/r) acute myeloid leukemia (aml) or r/r non-hodgkin's lymphoma (nhl)/diffuse large b-cell lymphoma (dlbcl) confirmed by the world health organization (who) criteria, as appropriate. * meets the following disease activity criteria: * aml: must have received at least 1 prior therapy for aml and be ineligible for cytotoxic therapy and allogeneic stem cell transplant. * nhl/dlbcl: measurable disease with a bidimensional lesion measuring at least 1.5 cm; received at least 1 prior therapy for nhl with no curative treatment option as determined by the investigator and be ineligible for a stem cell transplant. exclusion criteria: * history of clinically significant medical condition that, in the opinion of the investigator, would adversely affect participation in this study. * history of of any malignancy within the last 6 months except for those specified in this protocol and low-grade malignancies not requiring active treatment such as non-melanoma skin cancer, cervical intraepithelial neoplasia, or prostate cancer in situ. * prior allogeneic stem cell transplant or autologous stem cell transplant within 100 days of study drug administration and no signs or symptoms of acute or chronic graft-versus-host disease. * previous enrollment in a randomized trial including either venetoclax or amg 176. * known active or chronic pancreatitis; severe chronic obstructive pulmonary disease with hypoxemia; central nervous system manifestations of malignancy. * active, uncontrolled infection.

Keywords: acute myeloid leukemia non-hodgkin's lymphoma cancer venetoclax amg 176 diffuse large b-cell lymphoma (dlbcl)
zhongshan iridocorneal endothelial syndrome study (ices)

Conditions: Glaucoma

Summary: this is a multi-center study to report the demographic profile, clinical features, and management in patients with iridocorneal endothelial (ice) syndrome in china.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of ice syndrome; * those willing to sign the informed consent. exclusion criteria: * patients who don't sign the informed consent or abide by the study procedure.
postoperative dexmedetomidine in prevention of postoperative delirium

Conditions: Delirium in Old Age; Anesthesia; Adverse Effect

Summary: the goal of this clinical trial is to learn how postoperative infusion of dexmedetomidine would influence postoperative delirium in elderly patients undergoing lung surgery. the main questions it aims to answer are : 1. does postoperative dexmedetomidine reduce the incidence of delirium after lung surgery? 2. does postoperative dexmedetomidine introduce other medical problems? researchers will compare dexmedetomidine and sufentanil to see if dexmedetomidine works to reduce delirium. participants will undergo routine postoperative care: 1. patient-controlled self anesthesia with sufentanil only or combination of sufentanil and dexmedetomidine 2. postoperative visit twice a day for at least seven days


Eligibility criteria:
inclusion criteria: * elective surgery for lobectomy or segmentectomy exclusion criteria: * local allergy to anesthetics; * patients with a clear preoperative history of nervous system and mental system diseases or long-term use of sedatives or antidepressants; * history of alcoholism, drug abuse or drug dependence; * have a history of brain surgery or injury; * epilepsy and associated mental and cognitive dysfunction, long-term stress stimulation, or psychological disorders; * sick sinus syndrome, second-degree or greater atrioventricular block or other contraindications for use of α2 adrenergic agonist; * liver and kidney insufficiency.
the effects of energy imbalance on food intake behaviors

Conditions: Obesity

Summary: this study will determine whether changes in energy balance alter regional neuronal activation of brain regions associated with food intake in individuals screened to be either resistant or prone to obesity. specifically, it will determine whether foods of "hedonic" value elicit changes in regional neuronal activity in the fasted and fed state in "obese-resistant" and "obese-prone" men and women in varying states of energy balance.


Eligibility criteria:
inclusion criteria: in the obese-prone group: * bmi between 20-30 * report at least one obese first-degree relative * self-describe as "struggling" with weight * weight-stable for at least 3 months prior to study participation in the obese-resistant group: * bmi between 17-25 * report no obese first-degree relatives * self-describe as "naturally thin" and have never been overweight * overall weight stability exclusion criteria: * significant medical or psychiatric disease * history of eating disorder * left handed * unable to complete an mri scan (e.g., metal in body, claustrophobic)
serologic profile of sars cov2 in covid-19 patients with systemic diseases

Conditions: SARS-CoV Infection; Systemic Disease; Systemic Lupus Erythematosus; Sjogren's Syndrome; Sarcoidosis; Inflammatory Myopathy; Behçet Disease; Rheumatoid Arthritis; Spondyloarthritis

Summary: an observational study aiming to assess the serological profile of sars-cov2 patients with systemic diseases such as systemic lupus erythematosus, sjogren syndrome, sarcoidosis, inflammatory myopathies, behçet's disease, rheumatoid arthritis and spondyloarthritis

the study is a prospective, observational, multicenter clinical trial to be conducted in the internal medicine, rheumatology and virology departments of military hospital of tunis. after obtaining informed consent from the patient, the investigator will perform an inclusion visit made of a patient interview and performing blood sample to search for igg and anti-sars igm cov2. patients with igm-like antibodies will have an rt-pcr test for active infection. if the study participants will be diagnosed with covid-19 positive during the study period, the attending physician is entitled to decide on their management based on the severity of the clinical status.

Eligibility criteria:
inclusion criteria: * age over 18 years old * one of the following conditions: systemic lupus, sjögren's syndrome, rheumatoid arthritis, inflammatory myopathies, spondyloarthritis, sarcoidosis and behçet's disease. * informed consent obtained and signed exclusion criteria: * refusal to repeat blood sampling if the first one was badly performed * informed consent not obained
evaluation of the clinical performance of the quantra system with the quantra surgical cartridge

Conditions: Blood Loss, Surgical

Summary: this study will evaluate the performance of the quantra system comprised of the quantra hemostasis analyzer with the quantra surgical cartridge in patients undergoing major surgical procedures specifically, major cardiac and vascular procedures and major orthopedic surgery (primarily complex spine surgeries).

the quantra system is a fully integrated and automated in vitro diagnostic device which uses seer sonorheometry, an ultrasound-based technology, to characterize the viscoelastic properties of a whole blood sample during coagulation. the quantra surgical cartridge was developed to monitor hemostasis during major surgical procedures in adult patients. the cartridge consists of four independent channels each containing different sets of reagents, which provide four measurements performed in parallel yielding six parameters that depict the functional status of a patient's coagulation system. this multi-center, prospective, observational study will evaluate the performance of the quantra system as compared to standard coagulation tests and comparable measures determined using the rotem delta.

Eligibility criteria:
inclusion criteria: * subject is ≥18 years * subject is scheduled for either 1) cardiac or vascular surgery utilizing cardiopulmonary bypass (cpb) or 2) orthopedic surgery including major deformity correction spine surgery * subject has a cardiac assist device and is hospitalized for any procedure * subject underwent cardiac, vascular or orthopedic surgery and presents with acute bleeding or suspected hypercoagulability in a post-surgical unit * subject is undergoing emergency cardiac, vascular or orthopedic surgery * subject is willing to participate and he/she has signed a consent form exclusion criteria: * subject is unable to provide written informed consent * subject is younger than 18 years * subject is incarcerated at the time of the study * subject is pregnant * subject is currently enrolled in a study that might confound the result of the proposed study * subject is affected by a condition that, in the opinion of the surgical team, may pose additional risks

Keywords: viscoelastic testing coagulation quantra hemostasis
delirium detection in pediatric intensive care unit through a french translation of the capd : a french monocentric observational study

Conditions: Delirium

Summary: the purpose of this study is to introduce delirium detection and try to determine the prevalence of delirium in pediatric intensive care unit (picu) using a validated tool : the cornell assessment of pediatric delirium (capd) for every patient twice a day.

delirium is a frequent affection in icu. in adult population, its prevalence is 20-50% in non intubated patients and 60-80% in patients under invasive ventilation. it is also frequent in paediatric population, but less diagnosed, whereas it can lead to higher duration stay, higher morbidity, traumatic injuries, acute stress, memory losses and post-traumatic stress syndrome. since 2016, international guidelines recommend to look for delirium in paediatric population in picu. there are 3 recommended tools to diagnose this affection: pscam-icu (6 months-5 years old), pcam-icu (5 years old-18 years old) and capd (birth-18 years old). none of these validated tools have been translated in french. the principal objective is to study the practicability of twice a day detection of delirium in picu using the capd. investigators will first used a validation process to translate the capd in french, based on the validation method for psychological questionnaires suggested by vallerand. then they will ask the paramedics to evaluate through the capd every consecutive patient/12 hours, every day during their stay in picu, except for those completely unresponsive or under curare. this systematic evaluation will take place for 2 consecutive months. for every patient, data will be collected about their age, sexe, term of birth, mental affection status, diagnosis at entry, and daily risk of mortality score, length of stay, ventilation, pain evaluation and treatment, withdrawal evaluation, surroundings, use of hypnotic treatment, steroids, opioids and ketamine. the secondary aims are to determine the prevalence of delirium with the data collected, to ask whether or not the french version of capd has been easily and correctly used, can help to diagnose delirium, and whether investigators can find some associated parameters to delirium.

Eligibility criteria:
inclusion criteria: * being hospitalized in picu during the inclusion period * age 0 to 18 years old exclusion criteria: * patient with a state of sedation that does not allow the assessment of a change in the state of consciousness or cognitive functioning (equivalent score richmond agitation-sedation scale rass \<-3 or comfort b \<11) * patient or parental opposition to the observational study

Keywords: delirium paediatric intensive care unit capd (cornell assessment of paediatric delirium) french translation
a single session self-guided acceptance-based digital intervention targeting food cravings in pregnancy

Conditions: Pregnancy Weight Gain; Eating Disorders; Perinatal Problems; Binge Eating; Craving

Summary: pregnancy is a time of heightened risk for disordered eating behaviors, which have been linked to adverse health outcomes in gestation, delivery, and the postpartum. these adverse outcomes may at least in part be mediated by greater risk of deviation from recommended gestational weight gain trajectories, especially in those engaged in binge and loss of control eating. this study will explore the efficacy of a single-session, self-guided online acceptance-based intervention targeting food cravings as powerful and modifiable predictors of binge and loc eating in pregnancy.

pregnancy is a time of heightened risk for disordered eating behaviors, which have been linked to a range of adverse health outcomes in pregnancy, delivery, and the postpartum. these adverse outcomes may at least in part be mediated by greater rates of deviation from recommended weight gain trajectories, especially in those engaged in binge and loss of control eating. food cravings are powerful triggers of binge and loss of control eating in non-pregnant populations with preliminary evidence linking cravings to disordered eating behaviors and greater weight gain in pregnancy as well. this study builds on preliminary evidence to suggest that acceptance-based approaches are effective in reducing the adverse impacts of cravings on behavior by exploring the efficacy of a single-session, self-guided online acceptance-based intervention targeting food cravings in pregnant participants as predictors of maladaptive eating behaviors and deviations from recommended gestational weight gain trajectories. the efficacy of a single-session, self-guided online acceptance-based intervention targeting food cravings in pregnant participants will be examined in a randomized controlled trial. pregnant individuals in the second trimester (n = 130) who endorse current cravings will be randomly assigned to the intervention or an untreated control group. the intervention group will participate in a single-session, self-guided online workshop imparting skills grounded in acceptance and commitment therapy, including acceptance, defusion, and present-moment awareness. both groups will complete comprehensive assessments at baseline, one-month follow-up, and at full-term. the results of this initial efficacy trial will inform the integration of acceptance-based self-guided health coaching targeting food cravings into routine prenatal care to prevent adverse outcomes associated with disordered eating behaviors in pregnancy.

Eligibility criteria:
inclusion criteria: * age 18 and older * current residence in the united states * fluency in english * currently pregnant in the second trimester * experience of any food cravings exclusion criteria: * none beyond not meeting inclusion criteria

Keywords: gestational weight gain loss of control eating binge eating food craving mobile health intervention single session intervention acceptance and commitment therapy
caregiver support and post-operative convalescence

Conditions: Pelvic Organ Prolapse

Summary: this is a prospective cohort study designed to investigate the impact of home caregiver support on post-operative convalescence in patients undergoing same day discharge after major urogynecologic surgery. questionnaires assessing post-operative convalescence will be distributed at several time points after surgery. the main hypothesis is that increased caregiver support in the post-operative period will improve post-operative convalescence of patients undergoing major urogynecologic surgery.

pelvic organ prolapse and incontinence surgery is now often done on an outpatient basis (also known as same day discharge surgery or sdd). while there are data to support the safety of this practice, little is known about the burden and demands of this practice on the patient and her support system/caregivers. furthermore, there are no guidelines on requirements for assistance at home or what impact home caregiver support has on recovery. the study team is interested in investigating the spectrum of support that patients have at home in terms of caregivers such as family, friends, neighbors and how that may impact their recovery. the intervention for this study will be comprised of administering post-operative questionnaires that assess patients' post-operative convalescence and quantify the required or available caregiver support. the clinical outcome of interest is recovery as assessed by the validated questionnaires.

Eligibility criteria:
inclusion criteria: * age 18 years or older * english speaking * successfully discharged on the day of surgery exclusion criteria: * discharge to a nursing home, assisted living or rehabilitation facility. * dementia or altered mental status that would make recall of recovery process unreliable. * inability to access internet or phone for study participation

Keywords: prolapse same day discharge caregiver
haemodynamic effects of dobutamine and nitrite in lv dysfunction

Conditions: Heart Failure

Summary: patients with poor heart function can, in certain situations, have a further weakening of the heart muscle such that it becomes difficult to provide enough blood to the brain and other organs. in these cases, heart function can be supported by the use of medicines or heart pumps. one of the most widely used medicines is dobutamine, given as an infusion (a drip). although dobutamine has been in use for decades and does improve blood flow to the organs, previous studies have not shown any impact on recovery of heart muscle function and survival. key to unravelling this discrepancy is to understand the precise effects of dobutamine on the oxygen supply to, and oxygen usage by, the heart muscle. we also aim to find out whether simultaneous infusion of another drug called nitrite (naturally occurring substance that is found in beetroot for example, much like gtn) can enhance the beneficial effects of dobutamine on the oxygen supply-demand balance of the heart. in recent years, major advances in technology mean that it is now possible to obtain this information in patients undergoing coronary angiography procedures by making detailed measurements of heart muscle function and blood flow in the heart arteries using a conductance catheter (measures volume and pressure within the main pumping chamber of the heart) and the combowire (dual pressure and flow sensor tip angioplasty guidewire). the aim of this study is to understand the effect of a brief infusion of dobutamine and nitrite on heart muscle function, oxygen supply and oxygen usage through this use of this technology, directly following the patients routine coronary angiogram. patients will have these measurements taken using the technology described above during the infusion of both dobutamine and nitrite, inserted through blood vessels that reach the heart.


Eligibility criteria:
inclusion criteria: 1. left ventricular ejection fraction \<40% 2. patients aged \>18 years 3. able to provide written consent exclusion criteria: 1. known acquired or congenital structural heart disease such as severe valve disease, ventricular/atrial septal defects 2. haemodynamic instability 3. severe disease in major proximal coronary arteries or planned percutaneous coronary intervention during the index procedure
corneal wfg versus af trans prk in myopic patients with high corneal hoa

Conditions: Myopia

Summary: compare the efficacy, safety and predictability of corneal wavefront guided (wfg) and aberration free ablation in single-step transepithelial photorefractive keratectomy (transprk) in myopic patients with high pre-existing corneal higher order aberrations (hoas).

objectives:to compare the efficacy, safety and predictability of corneal wavefront guided (wfg) and aberration free ablation in single-step transepithelial photorefractive keratectomy (transprk) in myopic patients with high pre-existing corneal higher order aberrations (hoas). background: corneal wfg and aberration free treatments have been proposed as methods to achieve better visual, refractive, and optical outcomes. methods: prospective case series was conducted in el-hekma eye-lasik center, menoufia governorate, egypt during the period from january 2017 to december 2017. transprk was performed to eligible myopic patients with or without astigmatism with corneal hoas ≥ 0.35 µ utilizing either aberration free or corneal wfg patterns provided by orkcam software (schwind eye-tech-solutions, kleinostheim, germany). uncorrected distance visual acuity (udva), manifest and cycloplegic refractions, best spectacle corrected distance visual acuity (cdva), thorough slit lamp examination and corneal topography were assessed and repeated six months postoperatively.

Eligibility criteria:
inclusion criteria: * myopic patients with or without astigmatism exclusion criteria: * severe dry eye, * blepharitis, * corneal disease, * contact lens warpage, * cataract, * uveitis * posterior segment anomalies involving the macula or optic nerve * systemic conditions; diabetes mellitus, connective tissue disease, pregnancy or nursing. also, any patient who had previous ocular surgery including keratorefractive surgery was excluded

Keywords: aberration free corneal wavefront guided higher order aberrations photorefractive keratectomy.