Kornimate/medical-research-clean huggingface dataset:
measuring the impact of care in the cognitive behavioural unit

Conditions: Severe Disruptive Behaviour Disorders

Summary: the purpose of this study is to compare the rate of re-hospitalizations in relation to a disruptive behaviour disorder (at 3 and 6 months) between patients who have received care in cognitive behavioural unity (ucc ) and those who have received care in geriatric follow-up and rehabilitation care unit (ssr).

the purpose of this muliticentric non-interventional study is to compare the rate of re-hospitalization in relation to a disruptive behaviour disorder between patients receiving care in cognitive behavioural unity ucc (target arm) and those who have received care in geriatric care unit and rehabilitation ssr (control arm ). at inclusion (month 0) : inclusion of patients admitted in ucc or in geriatric ssr units for less than 8 days after obtaining of their non opposition. following data: socio-educational level, somatic and psychiatric comorbidities, classification of the type of dementia, evolution of nutritional status, biology (hemoglobin, creatinine, albuminemia), cognitive evaluation, treatment, pain assessment, assessment of disruptive behaviour disorders, discharge modalities, assistance plan, legal protection (before and after hospitalization), types of restraints, measurement of fall rates and their consequences, pathology and/or symptoms observed ( incidents) during hospitalization and vital status will be collected at inclusion and follow-up (1, 3 and 6 months ). at 1 month (m1), exit from hospitalization (m1): data provided by investigator . at 3 months (m3) and 6 months (m6) after discharge from hospital in ucc or ssr: sponsor's clinical research associateall call patient (or his legal representative) or to the primary caregiver or attending physician or ehpad coordinating physician for collection of questionnaires.

Eligibility criteria:
inclusion criteria: * 70 ≥ years of age * patient with severe disruptive behaviour disorders with a score (frequency x severity) \>7 to at least one of the 7 items targeted on clinician neuropsychaitric inventury (npi-es) scale * patient who was not cared for in cognitive behavioural unit (ucc) within 6 months prior to admission * patient entered center less than 8 days * affiliation to a social security scheme * patient or legal representative has expressed his non-opposition exclusion criteria: * 70 \< years of age * patient with no score (fxg) \>7 to at least one of the 7 items targeted on clinician neuropsychaitric inventury npi-es scale * patient who was cared for in ucc within 6 months of admission * entered centre for 8 days or more * not affiliated or entitled to a social security scheme * patient or legal representative has expressed his opposition

Keywords: severe disruptive behaviour disorders cognitive behavioural unit geriatric follow-up and rehabilitation care unit
first-time ablation of atrial fibrillation registry

Conditions: Atrial Fibrillation; Arrhythmia

Summary: atrial fibrillation (af) is a prevalent cardiac arrhythmia affecting millions globally, with projections indicating a doubling of cases by 2050. af is linked to heightened cardiovascular risks like stroke and increased healthcare costs. ablation, targeting the arrhythmia substrate, is a method to manage af, yet recurrence rates remain high (20-45% in the first year). studies highlight the impact of comorbidities, af characteristics, ablation techniques, and myocardial remodeling markers on af progression and ablation efficacy. however, there's no definitive guidance on selecting these factors for predicting treatment success. the aim of this study is to investigate predictors of successful af ablation in the following areas: (a) clinical factors, (b) electrophysiological, (c) electrocardiographic, (d) ultrasound, (e) cardiac anatomy, (f) biomarkers.

af is a multifactorial disease influenced by many possible mechanisms. this study will examine several different predictors of successful af ablation: (a) clinical factors, (b) electrophysiological, (c) electrocardiographic, (d) ultrasound, (e) cardiac anatomy, (f) biomarkers. analysis of these factors will help determine the optimal combination of predictors of successful ablation. this combination of prognostic factors can then be used to tailor therapeutic decisions specifically to individual patients and to improve patient selection for invasive treatment. better patient selection and choice of ablation type can help increase success rates and avoid unnecessary procedures and their associated risks.

Eligibility criteria:
inclusion criteria: * paroxysmal or persistent af * first-time ablation of af exclusion criteria: * patients unable to give informed consent * serious health condition existing before ablation

Keywords: atrial fibrillation arrhythmia pulsed field ablation radiofrequency ablation catheter ablation prediction detection mobile health telemedicine
locally delivered minocycline in advanced periodontitis

Conditions: Periodontitis, Adult

Summary: local drug delivery provides higher concentrations in the availability of the drug at the specific infected sites with the advantage of sustained release. periocline is a long acting , sustained release local drug delivery system consisting of 2% minocycline hydrochloride in an ointment containing microcapsule type particles. periocline contains 20mg of minocycline in 0.5 gm of gel in a disposable polypropylene applicator (2% minocycline hcl). research has yielded promising results with the local application of minocycline in the treatment of periodontal disease, compared with other non-surgical therapies. however, there is scarcity of reports on the use of local delivery agents with respect to new range of putative pathogens in advanced periodontitis, wherein the tissue invasive anaerobic organisms are present and possibly compromised host response, hence resulting in an exaggerated breakdown of periodontal tissues at the affected sites. the effect of minocycline on new putative pathogens, such as filifactor alocis and oral phylotypes of phyla synergistetes and tm7 (referred to hereafter as oral synergistetes and oral tm7s), has not been investigated yet. hence, the aim of the present study is to evaluate the efficacy of a local delivery agent containing minocycline (periocline, sunstar, japan) as an adjunct to srp in the treatment of deep periodontal pockets around teeth in advanced periodontitis and the antimicrobial effect on the red complex and the new putative pathogens.

the subjects for this randomized controlled, parallel arm study will be selected from the primary health care in the faculty of dentistry, mahsa university. in this clinical trial, 50 patients with advanced periodontitis will be enrolled in the study.

Eligibility criteria:
inclusion criteria: * systematically healthy patients with age range between 20- 60 years, * diagnosed with untreated advanced periodontitis with a pocket depth ≥6mm around two or more teeth, in two or more quadrants. exclusion criteria: * patients given antibiotics or anti-inflammatory drugs in the past 6 months, * allergic to tetracycline, * pregnant or nursing females, * those using chlorhexidine or any other mouth rinse
is there a mechanistic reason for the response or non-response to isometric exercise in tendinopathy?

Conditions: Tendinopathy

Summary: in early phase tendinopathy, isometric exercises are seen as ideal to provide pain relief to patients. this approach is mainly based on a paper by rio et al (2016), where they found that isometric exercises of a certain load magnitude and time (5 repetitions of 45 second hold at 70% of maximum) gave 100% pain relief for 45 minutes in patients with patellar tendinopathy. this then helps patients to perform their more heavy load exercises during rehabilitation, which would otherwise be too painful. unfortunately, the study of rio et al only consisted of 6 participants, and recent papers have contradicted the findings. in achilles tendinopathy, plantar fasciopathy and lateral elbow tendinopathy, the pain relief was not consistently present, with "responders" and "non-responders" being found in these studies. also, a study yet to be published (poster at conference), replicating rio et al, also found a heterogeneous response, debunking the "one size fits all" approach that seemed to work. however, in our understanding, isometric exercises do have a crucial role in early tendinopathy management, but the way the exercise is performed, in which position, what magnitude of load, time under tension, ... has an important influence. the same protocol (5 repetitions of 45 second hold at 70% of maximum) might lead to big inter-individual differences. therefore, there might be a mechanistic reason why some patients respond, and others do not. fortunately, the p.i. of this current trial application has recently optimized an ultrasound-based method to quantify local tendon deformation during exercises. the main purpose of this trial is therefore to evaluate the local tendon deformation pattern of patients with tendinopathy during isometric exercises and evaluate whether there is an interindividual difference in pattern between "responders" and "non-responders".


Eligibility criteria:
inclusion criteria: - clinical diagnosis of patellar tendinopathy, consisting of * pain located at the proximal part of the patellar tendon * painful at palpation the proximal part of the patellar tendon * numeric rating scale \> 1/10 with squat on decline (20°) board exclusion criteria: * previous treatment for patellar tendinopathy * rupture of patellar tendon on ultrasound * unclear differential diagnosis with patellofemoral pain * concomitant neuromuscular disorders

Keywords: patellar ultrasound speckle isometric
a hepatitis b with hepatic steatosis study

Conditions: Hepatitis B, Chronic; Hepatic Steatosis

Summary: this is an epidemiologic study on effect of hepatic steatosis on prognosis and outcomes of patients with chronic hepatitis b.

this is a multicenter, prospective and open-enrollment epidemiologic study. all the patients with chronic hepatisis b will be enrolled in the study and followed up after 1 year, 3 years and 5 years with a visit window of +1 month.

Eligibility criteria:
inclusion criteria: 1. clinically diagnosed chronic hepatitis b. 2. specific biopsy requirements for hepatic steatosis: qualified biopsy specimen within 6 months, \>5% hepatocytes show macrovesicular steatosis under he staining and x10 microscope. 3. willing to participate in the long-term follow-up and cooperative. 4. able to provide informed consent file. exclusion criteria: 1. unable to provide informed consent. 2. patients are eligible for baseline analysis but not eligible for follow-up, if having any of the following condition: 1. any end-stage liver disease. 2. any malignant tumor. 3. any congenital liver disease such as wilson disease. 4. any other serious disease of projected survival \< 5 years.
military to civilian: trial of an intervention to promote postdeployment reintegration

Conditions: Posttraumatic Stress Disorder

Summary: veterans returning from combat deployments face the interrelated challenges of processing their combat experiences and transitioning back to civilian life. unfortunately, many veterans wait years or decades before seeking help for post-deployment problems, if they seek it at all. this study seeks to determine whether internet-based expressive writing (ib-ew), a brief, low-cost, easily disseminated, and resource-efficient intervention, can reduce psychological symptoms and improve functioning among operation iraqi freedom (oif) and operation enduring freedom (oef) veterans as they navigate this transition, while also attempting to reduce barriers to help-seeking. expressive writing, a highly private, readily accessible, and non-stigmatizing intervention, has a strong evidence-base in civilian populations, but its efficacy in combat veterans has not been tested. this study therefore seeks to test the efficacy of expressive writing in a veteran population while further enhancing its accessibility by delivering it over the internet (internet-based expressive writing; ib-ew). this study will comprise a randomized controlled trial with three conditions: (a) internet-based expressive writing, (b) internet-based control writing, and (c) no writing/treatment as usual, with a total of 1152 oif/oef veterans randomized across these groups. expressive writing participants will write with feeling about their transition from being a soldier to being a civilian; control writing participants will write factually about the information needs of new veterans; and treatment as usual participants will complete the assessments but not engage in any writing assignments. participants will complete standardized self-report measures of psychological symptoms, psychosocial functioning, and life satisfaction at baseline (session 1) and at three months (session 6) and six months (session 7) post-intervention. participants in writing conditions will write for 20 minutes on four consecutive days (sessions 2-5) following completion of baseline measures (participants in the tau condition will not complete sessions 2-5). the study will also attempt to identify individual difference characteristics related to the efficacy of the treatment, to see who may be most likely to benefit from the treatment. analyses will primarily entail multivariate analyses of variance. power is adequate to detect even a small effect.


Eligibility criteria:
inclusion criteria: * veteran from current wars in iraq and afghanistan * at least a little difficulty transitioning from soldier to civilian * access to computer with internet * provide valid contact information * available to participate for up to 40 minutes per session * interested in participation * understand procedures and consent * note: participants are recruited by random selection from the target population exclusion criteria: * severe depression

Keywords: clinical trial combat disorders ptsd internet-based intervention mental health services post-deployment reintegration
efficacy of manuel therapy and bety in patients with temporomandibular dysfunction related headache

Conditions: Temporomandibular Disorders; Headache

Summary: the aim of the study is to investigate the effects of manual therapy and the cognitive exercise therapy approach treatment in patients with tmd-related headaches.

60 subjects with tmd-related headaches, according to ichd-3, will be included in the study after the voluntary consent form will be filled out. subjects will randomly be divided into 3 groups according to the order. group 1: patient education and exercise group: the patients in this group will be taught an exercise program after general education. education training program about parafunctional activities of tmd and active exercises for masticatory and neck muscles. patients will be asked to complete and follow-up home exercises for 30-45 minutes once a day, 5 days a week for 8 weeks. the continuity of the exercises will be ensured by sending reminder messages to this group of patients about doing their exercises once a week by the physiotherapist. group 2; manuel therapy group: this group will receive the same patient education and exercises additionally manual therapy program which is planned to last 45 minutes will be applied twice a week, for 8 weeks. group 3; bety group: this group will receive the same patient education and exercises in addition bety approach, which is the cognitive exercise therapy approach treatment, will be applied in 2 sessions a week for 45 minutes and a total of 8 weeks of treatment.

Eligibility criteria:
inclusion criteria: * ages between 18 and 60 years old * getting a diagnosis of tmd-related headache * not having received ftr and manual therapy in the last 3 months * having pain ≥ 50 or more according to the headache impact test (hit 6) * patients who have not received medical treatment in the last 3 months and will not receive medical treatment during the treatment * patients who describe pain in the jaw, face, temporal region or ear for at least 6 months and who have pain in the chewing muscles with palpation exclusion criteria: * ages under 18 and over 60 years old * patients with disc displacement and/or attachment degeneration * patients with dental infection * patients who have undergone facial and ear surgery in the last six months * patients undergoing orthodontic treatment * patients using regular analgesics or anti-inflammatory drugs * patients with a history of trauma (whiplash injury, condylar trauma, fracture), * patients who have undergone any surgery related to the cervical and/or tmj * patients with facial paralysis * patients with missing teeth in the upper jaw * patients with cognitive deficits * participation rate lower than 80% of the program schedule

Keywords: temporomandibular disorders, headache, quality of life, pain
pharmaco(epi)genetic, proteomic, and microbiomic study of obsessive-compulsive disorder

Conditions: Obsessive-Compulsive Disorder

Summary: the purpose of this study is to determine whether pharmaco(epi)genetic study predict selective serotonin reuptake inhibitor (ssri) responsiveness in advance before the appearance of the drug effect until 4 months(16 weeks), 6 months, and 1 year after administration of ssris.

the purpose of this study is to determine the effects of (epi)genetic variants on the response to ssris in obsessive-compulsive disorder (ocd) subject. the investigators will recruit drug-naive or drug-free(\> 3 months) ocd subjects (n=200). the participants will get ssris for their ocd symptoms. the type and dose of ssris will not be restricted and will depend on the individual participant's state. however, the investigators will be recommended to follow usual clinical guideline (the korean treatment algorithm for ocd, 2004). at baseline, 4 month, 6 months, and 1 year after treatment, the participants will be evaluated by yale-brown obsessive-compulsive scale(ybocs), montgomery asberg depression rating scale(madrs), dimensional obsessive-compulsive scale(docs), toronto alexithymia scale (tas), interpersonal reactivity index (iri), barratt impulsiveness scale (bis), and the measure of constructs underlying perfectionism(m-cup), beck depression inventory(bdi), beck anxiety inventory(bai), intolerance of uncertainty (iou), metacognition, disgust scale, early trauma inventory (eti). and a part of participants will be taken resting state functional mri. the research participants will donate approximately 10-15 ml of blood, from which we will extract dna and separate serum. using various (epi)genetic analyses, proteomics, and microbiome analysis (circulating bacterial extracellular vesicles) methods, we will analyze the association of various (epi)genetic variants, protein profiles, microbiome and the anti-obsessive-compulsive responses.

Eligibility criteria:
inclusion criteria: 1. age 19\~ 70 2. ocd by diagnostic and statistical manual for mental disorders, 4th edition (dsm-iv) 3. drug naive or drug free for more than 3 months exclusion criteria: 1. any neurological disorder 2. comorbid psychotic disorders 3. alcohol or other substance dependence within past 6 months 4. any evidences for brain diseases

Keywords: obsessive-compulsive disorder pharmaco(epi)genetics microbiome proteome
risk factor for cholestasis in neonates receiving tpn(total parenteral nutrition)

Conditions: Neonatal Cholestasis; Total Parenteral Nutrition Effect

Summary: the aim of this study is to evaluate the risk factors of pnac in neonates

neonates with prematurity,gastrointestinal dysfunction and very low birth weights are often intolerant to oral feeding.in such infants,the provision of nutrients via parenteral nutrition (pn)becomes necessary for short term survival,as well as long-term health. wilmore and dudrick first reported use of parenteral nutrition(pn) for an infant more than 40years ago soon there after physicians recognized that pn was associated with significant liver changes.in the first reported case of parenteral nutrition-associated conjugated hyperbilirubinemia (pnac) in a premature infant hepatomegaly was noted on the18thday of fat-free pn and worsened until death on the71st day of life the hyperbilirubinemia manifest in pnac is thought to occur from impaired hepatic bileflow, an adynamic gallbladder,and an upsurge in release of conjugated bilirubin as an infant matures.atbirth,preterm neonates havereduced activity of the uridine diphosphate glucuronosyl transferase1a1 liver enzyme(udpgt)that catalyzes conjugation of bilirubin as the infant develops,udpgt becomes more functional, increasing hepatocyte efficiency for conjugation.thus,in combination with cholestasis,and neonatal intestinal absorption of unconjugated bilirubin,more conjugated bilirubin is made available to pass from the liver into circulation. parenteral nutrition associated cholestasis (pnac) is the most common form of liver damage in neonates while receiving parenteral nutrition(pn).its prevalence was reported between10%and 60%in nicu cholestasisis acommonly described complication of pn. its etiology is not fully understood and is thought to be multifactorial proposed mechanisms included altered bile salt metabolisms secondary to prematurity and toxic effect of pn components on the liver the presence or absence of specific components in parenteral nutrition solutions most certainly contributing to the disease mechanism,and gastrointestinal systems .aggravating factors such as sepsis and duration of bowel rest have also been described

Eligibility criteria:
inclusion criteria: * neonates who received pn for ≥14 days exclusion criteria::neonates with major congenital anomaly, cholestasis at birth,diseases associated with cholestasis (i.e.,inborn errors of metabolism,viral hepatitis,cystic fibrosis and any primary cholestatic liver diseases)that were diagnosed while hospitalized.the possibility of surgical causes of conjugated hyperbilirubinemia(such as biliary atresia,choledochalcyst on abdominal ultrasonography,and hepatobiliary scintigraphy -

Keywords: tpn
learning skills in shoulder dystocia delivery using simulator models

Conditions: Shoulder Dystocia - Delivered; Birth Disorder

Summary: learning skills on shoulder dystocia on doctor and midwife

active learning on mannequin for shoulder dystocia deliveries on doctor and midwife using role play approach and its effect on clinical practice using questionnaires after first training and 6 months training

Eligibility criteria:
inclusion criteria: * residents and specialists in obstetrics and gynecology * midwives exclusion criteria: * none

Keywords: emergency delivery shoulder dystocia mannequin