Kornimate/medical-research-clean huggingface dataset:
cognitive assessment for stroke patients: reproductibility and validity study

Conditions: Stroke

Summary: after a cva, all of the cognitive functions can be affected and analysed, but the presence of a language disorder may considerably hamper the evaluation of other functions. the battery of rapid tests to screen for and quantify cognitive disorders, including the mmse, the moca, the r-camcog or the rbans, are not suitable for aphasic patients because they contain items with a strictly verbal response. because of this, inexperienced doctors cannot evaluate higher functions (other than language) of aphasics in routine practice. for the same reason, aphasics are regularly excluded from post-cva therapeutic protocols, whether or not the trial bears on the evolution of cognitive functions. nonetheless, it is possible to evaluate, at least roughly, all of the cognitive functions without resorting to language. the investigator have developed , from validated tests and classical clinical manoeuvers, the cognitive assessment for stroke patients (casp) : * for the rapid screening (less than 15 minutes) and quantification of post-cva cognitive disorders (6 functions: language, apraxia, short-term memory, temporal orientation, impaired spatial/visio-construction and executive functions); * the casp can be used in most patients, including those with severe disorders of expression and moderate problems with comprehension, the format of these tests has been adapted so that severe disorders of expression (essentially left-hemisphere cva), and left spatial impairment (right-hemisphere cva) do not affect the ability to take the test. its validity in terms of appearance and content were verified in 2011.


Eligibility criteria:
inclusion criteria: for cva patients * patients hospitalised in rehabilitation after a first recent hemispheric cva (less than 6 weeks) ; * aged \> 18; * absence of severe disorders of oral comprehension (bdae aphasia severity score \>2 for comprehension); * whatever the severity of oral expression disorders; * who have been given clear written and oral information, and after the doctor has verified their ability to understand the protocol. for " control " patients (to evaluate divergent validity) * patients hospitalised in rehabilitation units or geriatrics taking part in this study; * aged \> 18. exclusion criteria: for cva patients * patients who do not speak french; * cognitive disorders known before the cva; * psychotic disorders known before the cva; * major visual disorders incompatible with reading, known before the cva. for " control " patients (to evaluate divergent validity) * patients who do not speak french; * cognitive disorders known before the cva; * psychotic disorders known before the cva; * major visual disorders incompatible with reading, known before the cva.
evaluation of vitamin a and e deficiency with severity of sars-cov-2 disease: a case-control study

Conditions: COVID-19

Summary: coronavirus disease 2019 (covid-19) is a novel infectious disease that has been spreading worldwide coronaviridae study group of the international committee on taxonomy of viruses (2020). the clinical manifestation of covid-19 can range from asymptomatic infection to critical illness with severe pneumonia, respiratory failure, and death. vitamin a is of special interest in the field of infectious diseases, especially for pulmonary infections. it is crucial for the development of normal lung tissue and tissue repair after injury due to infection. therefore, it may play a role in recovery after severe covid-19 pneumonia. vitamin a has immune regulatory functions and positively affects both the innate and adaptive immune cell response. the anti-oxidant vitamin e, and trace element selenium, are major components of anti-oxidant defense. epidemiological studies demonstrate that deficiencies in, either of these nutrients, alters immune responses and viral pathogenicity. data concerning vitamin a and e plasma levels in covid-19 patients are lacking. therefore, this study aims at characterizing vitamin a and e plasma levels in covid-19 and analyzing the association of plasma levels with disease severity and outcome.

the aim of the current study is to evaluate the relation of plasma level of vitamin a and e and their correlation with severity of sars-cov2 disease.

Eligibility criteria:
inclusion criteria: * covid-19 positive patients by pcr (polymerase chain reaction) test * patients aging 18 to 75 years exclusion criteria: * patients with known immunodeficiency - patients with known lung diseases

Keywords: covid-19
new vectorcardiogram analysis a good predictor of coronary disease in patients with normal rest 12-leads ecg

Conditions: Cardiovascular Disease

Summary: the aim of this study is to determine whether a new vectorcardiogram (vcg) analysis will facilitate the detection of significant coronary disease (cad) in patients with normal rest 12-leads ecg (ne).

patients with ne will undergo coronary angiography for routine indications. prior to the angiography a computerized simultaneous multi-leads ecg will be recorded and, using a new dedicated algorithm for 3d electrical activity reconstruction, the investigators will plot the horizontal vcg of the whole ecg cycle. using this new vcg analysis we will determine whether the patients have normal coronary arteries or coronary disease.

Eligibility criteria:
inclusion criteria: * patients with normal rest 12-leads ecg exclusion criteria: * patients with significant irregular heart beat * patients with heart failure
standard post market clinical follow-up (pmcf) study wsa 2025

Conditions: Hearing Loss, Sensorineural

Summary: the purpose of the study is to follow-up on a released low-risk device as part of standard pmcf activities.

this is a comparative study which is conducted monocentric at hoerzentrum oldenburg, germany. the focus is to test a released hearing aid and compare this to the subject's own hearing aids with a minimum of 16 adult subjects with mild-to-moderate sensorineural hearing impairement. the subjects, all native german speakers, have 2 appointments of 1-2 hours including a fitting procedure with real-ear measurements and selected standard speech tests and undergo two 2-weeks home trials of the test hearing aid (with questionnaires).

Eligibility criteria:
inclusion criteria: * sensorineural hearing loss, mild-to-moderately severe (pure tone average of 500, 1000, 2000 and 4000 hz \<65). * hearing loss should fall within fitting range of study hearing aid * subjects should be experienced hearing aid users who have had and used hearing aids daily for at least 1 year. * air-bone-gap should be less or equal to 20 db. * asymmetry between left and right ear should not exceed 20db for frequencies in the range of 250hz to 4khz * healthy (outer and middle) ear * older than 18 years * german is mother tongue * able to understand the instructions * willing to participate in laboratory tests and to wear the study has at home for 2 weeks * informed consent exclusion criteria: * contraindication for ha treatment * fluctuating or rapidly progressing hearing loss * "central" hearing problems * limited mobility * limited dexterity (in handling the ha) * known psychological or cognitive problems * subjects must not show any injuries or a complete perforation of the ear drum. this must be clarified prior to the beginning of the study by means of otoscopy. * subjects should be in good overall medical condition (e.g., they shall not suffer from dementia) and should not use medical treatments that might affect study results.

Keywords: hearing aid freiburger matrix test ssq ioi-ha
bladder management in patients with multiple sclerosis: optimizing practice patterns

Conditions: Multiple Sclerosis; Urinary Bladder Diseases

Summary: this study will assess the impact of a systematic bladder health screening and disease education regimen as well as the implementation of a referral process on the quality of life of multiple sclerosis patients with bladder dysfunction.


Eligibility criteria:
inclusion criteria: * diagnosis of relapsing-remitting multiple sclerosis and currently being treated by study doctor exclusion criteria: * diagnosis of primary-progressive, secondary-progressive, or progressive-relapsing multiple sclerosis
animal-assisted interactions in children with life-threatening conditions and their parents

Conditions: Advanced Cancer; Relapsed Cancer; Refractory Cancer

Summary: this study will evaluate the effects of animal-assisted interactions (aai) on stress, anxiety, and quality of life in children with a life-threatening condition and their parents. it is anticipated to be a milestone in understanding the human-animal bond.

objectives: 1. examine the feasibility of animal-assisted interactions sessions for children with a life-threatening condition and primary caregiver to: * identify and document modifications for a safe and feasible intervention, * obtain recruitment estimates and determine potential recruitment barriers * evaluate elements of implementation fidelity (design, training, delivery/receipt of treatment, enactment) * verify safety. h1-1: children and parents (\>60%) will complete the interventions and provide positive acceptability data. h1-2: implementation fidelity can be achieved with the proposed methodology 2. determine the preliminary efficacy of animal-assisted interactions sessions for: * children with a life-threatening condition (ltc) for the outcome of health-related quality of life * children with a ltc and their primary caregivers for the outcomes of stress and anxiety h2-1 children with a life-threatening condition who receive animal-assisted interactions will experience improved health-related quality of life (hrqol) more than patients who do not receive animal-assisted interactions. h2-2a children with life-threatening condition who receive animal-assisted interactions will experience decreased stress and anxiety more than parents of children who do not receive animal-assisted interactions. h2-2b primary caregivers of children with a life-threatening condition who receive animal-assisted interactions will experience decreased stress and anxiety more than parents of children who do not receive animal-assisted interactions.

Eligibility criteria:
inclusion criteria: * children 3-17 years old * confirmed diagnosis of relapsed or refractory cancer exclusion criteria: * reported fear or anxiety of dogs (child or parent)
detection of copd in primary care

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is a common chronic disease with a significant medical and economic impact. its prevalence is increasing and is estimated at 7.5% of people over 40 in france. copd is responsible for a significant impairment of quality of life and was the 3rd leading cause of death in the world in 2010 when it was 4th place 20 years ago. however, about 75% of patients with copd are not diagnosed. spirometry is the only examination for the diagnosis of copd. patients identified at risk for copd are insufficiently using spirometry and general practitioners (gps) underestimate the severity of copd when they do not practice spirometry in their patients. copd is often diagnosed too late, the disease being discovered at the stage of complications requiring hospitalization. the underdiagnosis is mainly due to poor knowledge of patients, their difficulty in accessing a specialist performing spirometry, their reluctance to perform spirometry, and the insufficient involvement of general practitioners. currently in france, targeted screening for copd and diagnosis in primary care is a major challenge. the international (gold 2014) and french (has 2014) recommendations do not indicate a systematic screening in the general population for copd but advocate targeted screening of patients by five questions to identify risk factors and symptoms of copd. the presence of at least one of these factors in an adult over the age of 40 requires spirometry. recent studies suggest the relevance of finding primary care variables for smoking and respiratory symptoms in order to identify new cases of copd. however, the impact of the use of these questionnaires on the prevalence of diagnoses of copd in general practice has not been demonstrated. moreover, the heterogeneity of the provision of care according to the territories limits a fast or easy access (distance) to the spirometry. it is therefore necessary to evaluate in primary care the interest of a targeted screening of copd and the interest of a coordination of care for the realization of a spirometry, in order to improve the rate of diagnosis of the disease.


Eligibility criteria:
inclusion criteria: * patients with health insurance * non-opposition to participation in the study exclusion criteria: * copd known and confirmed by spirometry * asthma known and confirmed by spirometry * patient not having the physical or mental ability to perform spirometry * pregnant woman * patient under protection * patient already included in the study
how consistent is the output of derm, when used to assess images of potentially cancerous skin lesions.

Conditions: Skin Cancer; Melanoma of Skin; Squamous Cell Cancer; Basal Cell Cancer

Summary: derm is a medical device that uses artificial intelligence to help doctors check if a skin lesion might be cancerous. it works by analysing close-up pictures of skin lesions taken with a smartphone. this study aims to demonstrate how consistent (precise) the output of derm is: i.e. does it provide the same result when it analyses multiple photos of the same lesion (repeatability), and when the same lesion is photographed by different people, or with different cameras (reproducibility). adults with at least one skin lesion that doctors are checking for cancer, as part of their standard care, will be able to take part. suitable lesions will be photographed three times, each by three different people using three sets of image capture hardware (specifically, an iphone 11 with a dl200/hr dermoscopic lens). each image will be checked for good image quality as it is captured. images will then be transferred to derm, where they'll be analysed. the derm output won't be shared with the patients or doctors involved in the study. the patients will continue to have their skin lesion biopsy/excised, in accordance with standard of care. their diagnosis will be collected and compared to the output from derm.


Eligibility criteria:
inclusion criteria: * male or female, * aged 18 years or above, * willing and able to give informed consent for participation in the study, * has at least one skin lesion that, following assessment by a primary care provider and a dermatology specialist, will be biopsied due to a high suspicion of skin cancer, and is suitable for assessment by derm. * in the investigator's opinion, able and willing to comply with all study requirements. exclusion criteria: * patients with more than one skin lesion due for biopsy * any other significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study. to be suitable for inclusion, a skin lesion must not have any of the following limitations: * be located on an anatomical site of different skin structure: palms of hands or soles of feet (acral lesion), mucosal surfaces (lips and eyes) or under nail (ungal lesion), * have a diameter greater than the diameter of the dermoscopic lens, * be located on an anatomical site unsuitable for photographing, including on surface of genitals and hair-bearing areas, * have been previously biopsied, excised, treated or is otherwise traumatised * be located in an area of visible scarring or tattooing.

Keywords: precision derm repeatability reproducability
interventional study targeting oral infections in patients with chronic kidney disease

Conditions: Mouth Diseases; Renal Insufficiency, Chronic

Summary: this study aims to investigate the prevalence of oral infection in chronic renal disease patients and to examine whether a focused oral hygiene intervention can reduce oral infection leading to reduced systemic inflammatory parameters in chronic renal disease patients in hemodialysis, chronic renal disease patients waiting for kidney transplantation, and chronic renal disease patients who has been transplanted 1-1½ year previously. the results will be compared to a gender- and age-matched healthy control group.

aim: the aim is to examine if a focused oral care procedure to reduce oral infection will be mirrored in reduction of systemic inflammatory parameters in chronic renal disease patients. specific research questions: can oral infection and systemic inflammatory parameters in chronic renal disease patients be reduced by 1 month of professional oral care and individual prophylactic instruction and can a potential reduction of inflammation be continuously achieved at a 3 months follow-up. study design: randomized, double-blinded (investigator, outcomes assessor), controlled study. for eligibility criteria and outcome measures, please see elsewhere in the clinicaltrials.gov protocol registration system. participants: a: hemodialysis patients, inclusion n=34, b: hemodialysis patients on a kidney transplant waiting list, inclusion n=34, c: patients who have had a kidney transplant (1-1½ years after transplantation), inclusion n=34. d: gender- and age-matched healthy control group. number of included patients is estimated from a hypothesis-generating pilot study, a statistical power analysis and the estimated loss to follow-up based on experience from previous research projects in the nephrology department. intervention and control: the intervention consists of professional oral care (addressing periodontal and oral mucosal infections, salivary gland dysfunction and caries prevention) and a didactic approach to individual instruction in oral hygiene/prophylactic measures performed by a dental hygienist at three visits: baseline, 2 weeks after baseline and 1 month after baseline. the research data will be registered by a blinded investigator before the first visit at the dental hygienist and after 3 months. the control group will follow best-clinical-practice procedures currently implemented in the hospital.

Eligibility criteria:
inclusion criteria: * patients on a kidney transplant waiting list or patients who have had a kidney transplant (1-1½ year previously) * dentate patients (\>10 teeth) * age \>18 years * danish language exclusion criteria: * patients not capable of following the research protocol * legally unavailable * need of antibiotic prophylaxis with dental treatment * heart valve surgery

Keywords: mouth diseases renal insufficiency, chronic intervention studies
investigation of the correlation between polyamine levels and their key enzymatic activities in association with inflammatory bowel disease progression

Conditions: Inflammatory Bowel Diseases; Colitis, Ulcerative; Crohn Disease; Polyamines; Infliximab

Summary: inflammatory bowel disease (ibd), encompassing ulcerative colitis (uc) and crohn's disease (cd), significantly impairs patients' quality of life. current monitoring of disease activity primarily relies on endoscopy combined with histological examination, which is associated with high costs, invasiveness, poor patient tolerance, and risks of complications. additionally, disease activity indices and laboratory-based ibd staging metrics demonstrate limited utility and accuracy in clinical practice. this study aims to investigate the correlation between polyamine levels and their key enzymes in the polyamine metabolism pathway with ibd activity, thereby establishing a predictive model for ibd progression through polyamine and metabolite measurements; to estimate the efficacy of biologics via polyamine detection, providing a scientific basis for therapeutic selection; and to screen gut microbiota associated with polyamine metabolic alterations, offering evidence-based guidance for probiotic selection in ibd patients.

according to the inclusion and exclusion criteria, 91 patients with ibd diagnosed in the department of gastroenterology, the first affiliated hospital of air force medical university from november 2024 to september 2025 were included, and the subjects were divided into remission group and active group according to the corresponding ibd scale scores; 46 healthy controls were generally included according to the number of patients; in addition, 47 patients in the first biologic treatment group were included according to the inclusion and exclusion criteria. the ffq scale was used to calculate and evaluate the intake of polyamines in the enrolled patients, high performance liquid chromatography and mass spectrometry were used to measure the levels of polyamines in serum and fecal samples of patients, and immunohistochemical semi quantitative analysis of colon pathological sections was used to analyze the levels of key enzymes of polyamine metabolism.

Eligibility criteria:
inclusion criteria: 1. age between 18 and 65 years; 2. diagnosed with inflammatory (ibd) according to the chinese guidelines for the diagnosis and treatment of ulcerative colitis (2023, xi'an) and the chinese guidelines for the diagnosis and treatment of crohn's disease (2023, guangzhou); 3. complete medical records available and written informed consent obtained from the participant. exclusion criteria: 1. presence of other metabolic disorders; 2. history of malignant tumors, severe organ dysfunction, or other severe systemic diseases affecting major organs, or hematological disorders; 3. diagnosis of influenza, bacterial dysentery, or other infectious diseases within the past 2 weeks; 4. presence of other diseases that may interfere with polyamine metabolism; 5. use of antibiotics or probiotics within 8 weeks prior to the start of the study.
clinical follow-up of hip arthroplasty: a cross-section and longitudinal study

Conditions: Hip Arthropathy; Hip Replacement

Summary: this longitudinal follow-up study aims to analyze how surgical and patient characteristics affect clinical outcomes in the subjects received total hip arthroplasty (tha) or hemiarthroplasty (ha).

clinical assessments in this research include visual analogue scale (vas), harris hip score (hhs), oxford hip score (ohs), forgotten joint score (fjs-12) and x-ray imaging applied to examine the stability of implants. through analyzing surgical information, functional measures and self-reported questionnaires, this study intends to gain insights into the correlations between various clinical aspects.

Eligibility criteria:
inclusion criteria: 1. 20 years old at least. 2. osteoarthritis (oa) 3. avascular necrosis 4. rheumatoid arthritis (ra) 5. previous failure of hemiarthroplasty 6. femoral head or neck or trochanteric fractures 7. developmental dysplasia of the hip exclusion criteria: 1. being unable or unwilling to participate in 2. subjects having cognitive impairment cannot fill out survey 3. other complication causing severe deficiency in function and motion