Kornimate/medical-research-clean huggingface dataset:
discussion on the mechanism of acupuncture on patients with paroxysmal migraine without aura : a randomized controlled clinical trial

Conditions: Migraine, Dysmenorrhea

Summary: background: migraine is common but poorly managed with drugs. acupuncture, a non-pharmacological approach, has shown promise, yet its mechanisms remain unclear. this study aims to assess the efficacy and specificity of acupuncture for acute paroxysmal migraine without aura. methods: a randomized, single-blind, sham-controlled trial will recruit 60 patients from tongji hospital, china. patients will receive 20 sessions of deqi or sham acupuncture over 4 weeks and be followed for 8 weeks. treatments will occur twice within 4 hours of headache onset. primary outcome is complete headache remission within 120 minutes after two treatments without analgesics. secondary outcomes include headache intensity reduction, remission rates, and adverse events. blind assessment will be conducted after at least one session. data will be analyzed using full and per-protocol sets. ethics: approved by the clinical trial ethics committee (approval no: tj-irb20220573). written consent will be obtained. results will be published in a peer-reviewed journal.


Eligibility criteria:
inclusion criteria: * 1\\they met the diagnostic criteria of migraine without aura and had a history ofmore than 1 year; 2\\age 18-65 years old; * 18.5kg/m2 ≤ bmi ≤ 30.0kg / m2,right-handed; ④ the average frequency of migraine attacks in recent 6 months was ≥ 2-8 times per month; the average number of migraine attacks per month in recent 6 months was less than 15 days; the neurological examination was negative, and the ct or mri of the head was normal; there was no experience of acupuncture or migraine prevention and treatment in recent 3 months; able to complete the baseline migraine diary; agree to sign the informed consent form. exclusion criteria: * other types of primary headache or secondary headache; it is complicated with serious primary diseases such as cardiovascular,cerebrovascular, liver, kidney, gastrointestinal, blood, nervous system, etc; complicated with severe mental illness; in the past 12 weeks, migraine drugs were taken orally or headache treatment methods such as acupuncture and physiotherapy were received; lactation, pregnant women and planned pregnant women; participate in another clinical trial at the same time; illiterate, unable to read comprehension scale; poor compliance.
blood glucose management in intensive care units

Conditions: Insulin Hypoglycemia; Glucose Test Site Bleeding; Hyperglycemia

Summary: the investigators propose to conduct a study of practices to describe the methods of managing glycemic control in hospitalized patients in critical care. this is a prospective multicenter observational study conducted in intensive medicine and resuscitation departments in france and belgium. the aim of this study is to carry out an inventory of the current practices of glycemia management as well as their modalities. being one of the key points of the management, this work will have for main objective to raise the importance of the glycemic variabilities according to the methods of insulin therapies used.


Eligibility criteria:
inclusion criteria: * patient with hyperglycaemia requiring an insulin prescription within 48 hours of admission * insulin therapy started less than 12 hours before inclusion of the patient in the study * expected duration of hospitalization greater than or equal to 48 hours exclusion criteria: * moribund patients * patients admitted for ketoacidosis or hyperosmolar coma * patients admitted for symptomatic hypoglycaemia * patient requiring insulin for serum potassium correction * severe acute hepatocellular insufficiency * age \< 18 years old * pregnant or breastfeeding women * patients under legal protection measures

Keywords: glucose control insulin
peer education on hpv: impact on health sciences students' knowledge, awareness, and concern

Conditions: Human Papilloma Virus (HPV)

Summary: according to the world health organization (who), 400 million treatable sexually transmitted diseases (stds) such as syphilis, chlamydia and human papillomavirus (hpv) occur each year in people aged 15-49, mostly in developing countries. as hpv is a sexually transmitted virus, it has been shown to be the most important aetiological factor in cervical cancer in women (99.7%). vaccination and education of young people about sexuality and stds are very important in the prevention of hpv. in this respect, the aim of this study was to find out the level of knowledge, concern and awareness of hpv infection among university students and to increase their awareness by informing them about the subject through their peers. the study was conducted as a pre-test and post-test one-group study. the sample of the study consisted of all final year students of physiotherapy and rehabilitation (85 students), nutrition and dietetics (60 students), audiology (35 students), child development (80 students), health management (44 students) and social work (45 students) studying in the spring semester of the 2023-2024 academic year. the students were trained by the gynaecology nursing intern student group (9 students) of the department of nursing. data were collected using the sociodemographic characteristics form, the hpv knowledge scale and the human papilloma virus awareness and concern level scale (hpv-fas). the relevant forms and the consent form were completed by the students before, after and one month after the training.


Eligibility criteria:
inclusion criteria: * all individuals who are senior students in the faculty of health sciences departments and who agree to participate in the study will be included in the study. exclusion criteria: * individuals who did not complete the study and did not speak and understand turkish were excluded from the study.

Keywords: hpv peer education awareness
clinical study of ta-650 in patients with behcet's disease (bd) with special lesions

Conditions: Behcet's Disease; Behcet Syndrome; Neuro-Behcet's Disease

Summary: the purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of ta-650 in patients with behcet's disease ( bd ) with special lesions after the administration of ta-650 at a dosage of 5 mg/kg in weeks 0, 2, and 6, then every 8 weeks after week 14 up to week 46.


Eligibility criteria:
inclusion criteria: * patients who were diagnosed with the complete or incomplete type of behcet's disease according to "the criteria for a diagnosis of behcet's disease, ministry of health, labour and welfare in japan (partially revised in 2010)" * patients who have special lesions despite having received conventional treatments for special lesions, or patients who cannot receive conventional treatments due to intolerability. * patients who have clinical symptoms associated with each special lesions. exclusion criteria: * patients with intestinal, neuro-, vascular behcet's disease in whom a differential diagnosis of each behcet's disease from other conditions． * patients who have received treatment with infliximab within 1 year before enrollment for another purpose than treating special lesions; or patients whose previous treatment with infliximab was discontinued due to adverse events. * patients who had participated in another clinical study and had received a study drug within 12 weeks before giving acquirement.

Keywords: behcet's disease intestinal behcet's disease neuro-behcet's disease vascular behcet's disease
act on quality of life in patients with aortic stenosis

Conditions: Severe Aortic Stenosis

Summary: aortic stenosis (as) is a degenerative process affecting the aortic valve that leads to sclerosis of the valve and limits its opening during cardiac contractions. the prognosis is poorly, with survival rates of only 15-50% at 5 years. as has a major impact on quality of life, with severely limiting symptoms (dyspnea, chest pain,...) often leading to repeated hospitalizations. it is the most common valvular disease in europe and north america, and its prevalence is increasing as the population ages. in europe, 17% of the population is aged 65 or over; in france, this proportion will reach 30% by 2030, corresponding to 16 million people. the incidence of aortic valve sclerosis (early stage as) is around 25% at age 65, rising to 48% after age 75. the prevalence of aortic valve disease is likely to continue to rise, given the expected evolution of the age pyramid. there is no medical treatment able to slow down the degenerative process of the valve, and the only treatment is aortic valve replacement when the as becomes constricted and the patient is eligible for an intervention. aortic valve replacement has historically been performed surgically, with open-chest surgery to remove the damaged valve and replace it with a mechanical or biological valve prosthesis. now transcatheter aortic valve implantation (tavi) has replaced this procedure. this involves inserting a bioprosthesis crimped into a stent via an endovascular route, i.e. without opening the thorax. deployment of the stent crushes the native valve, leaving the functional bioprosthesis in place. initially developed for patients contraindicated to surgery, tavi is now offered as a first-line treatment for patients aged 75 and over. inexistent before 2010, the number of tavis equalled the number of surgeries by 2015, and tavis currently account for ¾ of aortic valve procedures (unpublished data).


Eligibility criteria:
inclusion criteria: * patients with symptomatic aortic stenosis (exertional dyspnea, angina, malaise/syncope) * indication for tavi (valve area 1 cm² or 1 cm²/m² body surface area or mean transvalvular aortic gradient \> 40 mmhg on ultrasound) validated in heart team * charlson score ≥ 5 * social health care insurance affiliation exclusion criteria: * patient refusing tavi procedure * ct scan not performed during the pre-tavi assessment * patient unable to understand or answer quality-of-life questionnaires * pregnant or breast-feeding women * patients participating in other interventional research that may interfere with the present study with an exclusion period still in progress * persons under judicial protection * patients under guardianship, curators or safeguard of justice

Keywords: tavi quality of life aortic stenosis
health, aging and later-life outcomes

Conditions: Aging

Summary: the purpose of this pilot research is to test the feasibility of two interventions focused on either reducing total calorie intake or reducing the total time that calories are ingested each day in older adults. participation in this research will involve visits to our clinic for testing and weekly intervention visits (in-person or remote depending on group assignment) for nine months with total participation lasting about a year.

this pilot study is part of a larger planning process to design a full-scale randomized trial to evaluate the long-term effects of caloric restriction (cr) and time restricted eating (tre) on the health of older adults. the specific objective of the hallo-p is to collect data to inform the design of the full-scale randomized trial to evaluate the long-term effects of caloric restriction and time restricted eating in older adults. the pilot is a 9-month clinical trial. the pilot data will be used to refine recruitment criteria, estimate recruitment yields, and refine intervention approaches.

Eligibility criteria:
inclusion criteria: * community-dwelling men and women residing in forsyth county, nc or surrounding counties * obesity (bmi = 30 - \< =40 kg/m2) or are overweight (bmi = 27 - \<30 kg/m2 with an indication for weight loss (e.g., hypertension, hyperlipidemia, elevated waist girth, controlled diabetes) exclusion criteria: * persons for whom the interventions are potentially unsafe * history of eating or nutritional disorders * those who are likely to drop out due to severe chronic illness or other reasons * who show inability to perform self-monitoring activities required by the interventions * those doing shift work because disturbances in circadian cycles may interfere with tre * uncontrolled or previously undetected diabetes because disease management may interfere with the interventions * certain medical treatments may complicate outcome interpretation

Keywords: older adults caloric restriction time restricted eating
rocamed urethral device (rud) and urinary retention in males

Conditions: Urinary Retention

Summary: prospective non randomized study of the feasibility of the insertion of rocamed urethral device by hand manipulation, i.e., without use of cystoscopy, sonography or fluoroscopy. patients with an acute urinary retention treated by foley catheterization in the emergency department have a few days later a trial of foley removal in the ambulatory unit of the urology department. in case of failure of the foley removal trial, i.e., recurrence of urinary retention, patients will be proposed either the insertion of a new foley or insertion of the urethral device. after signature of an informed consent, insertion of the urethral device will be performed after instillation in the urethra of a local anesthetic gel. device insertion success rate and complications will be studied. the device will be left in place for one month. tolerance and complications during the month with the device in place will be studied. at one month the device will be removed: the ease of retrieval of the device and complications will be studied. patient and doctor satisfaction with the urethral device will be compared to patient and doctor satisfaction with the foley.


Eligibility criteria:
inclusion criteria: * male \> 18 years old * acute retention treated by foley * failure of foley removal trial * clear urine * no urinary infection * efficient striated sphincter exclusion criteria: * urethral stenosis * hematuria macroscopic * urinary infection * anticoagulant treatment * lidocaine allergy

Keywords: urethral device foley catheterization
assessing cosopt switch patients

Conditions: Ocular Hypertension; Open-Angle Glaucoma; Exfoliation Syndrome; Glaucoma, Pigmentary

Summary: to assess the safety and efficacy of a cohort of patients switched to the dorzolamide/timolol maleate fixed combination because they are insufficiently controlled on latanoprost monotherapy.


Eligibility criteria:
inclusion criteria: * adults with clinical diagnosis of poag, pigment-dispersion or exfoliation glaucoma or ocular hypertension * the iop on latanoprost must be 31 mm hg or less in both eyes, and 21 to 31 mm hg inclusive in at least one eye at 08:00 am * visual acuity should be 20/200 or better in each eye exclusion criteria: * contraindications to study drugs * anticipated change in systemic hypotensive therapy during the trial * use of any corticosteroids by any route in the three months immediately prior to visit 2
gt201 injection in combination with teraplizumab injection for treatment of patients with non-small cell lung cancer

Conditions: Adult; Non-small Cell Lung Cancer

Summary: this study is a single arm, open design aimed at evaluating the safety and tolerability of autologous tumor-infiltrating lymphocyte (gt201 injection ) in combination with teraplizumab injection for treatment of patients with non-small cell lung cancer,while evaluating pharmacokinetic characteristics and efficacy assessment to determine the optimal biological dose (obd).


Eligibility criteria:
inclusion criteria: * 1. voluntarily join the study, signed informed consent form,, willing and able to comply with the study protocol; * 2. age 18 to 70 years old; * 3. eastern cooperative oncology group (ecog) performance status score of 0 or 1; * 4. expected survival time of ≥ 12 weeks; * 5. good function of vital organs; * 6. subjects entering this study due to disease progression must have an imaging record of disease progression before tumor sampling; * 7. at least one measurable target lesion that meets the definition of recist v1.1 after tumor sampling. exclusion criteria: * 1.patients with uncontrollable tumor-related pain as judged by the investigator; participants requiring analgesic medication must already have a stable analgesic regimen at the time of study entry; symptomatic lesions suitable for palliative radiotherapy should be completed prior to study entry; * 2.known mental illness, alcoholism, drug use or substance abuse; * 3.pregnant or lactating women; or women who are pregnant, breastfeeding, or planning to become pregnant within 1 year after cell infusion; * 4.those who have received other clinical trial drug treatment within 4 weeks before preconditioning by lymphodepletion,plan to participate in other clinical trial drug treatment during the study; * 5.the investigators determine that other conditions that make the patient not suitable for enrollment.

Keywords: gt201
the effects of remnant-preserving anterior cruciate ligament reconstruction on proprioception and functionality

Conditions: Anterior Cruciate Ligament Rupture

Summary: anterior cruciate ligament (acl) reconstruction is a frequently performed surgical procedure to stabilize the knee joint biomechanically. at the same time, one of the goals is to improve clinical outcomes and return the patient to their daily life as early and ready as possible, as well as to sports activities. remnant-preserving anterior cruciate ligament reconstruction is one of the reconstruction approaches that aim to achieve these goals earlier and more safely than the standard surgical procedure. however, there is no consensus in the literature regarding the effects of remnant-preserving acl reconstruction on clinical outcomes and its superiority over the standard surgical procedure. therefore, the aim of our study is to compare the proprioception and functionality of patients who underwent acl reconstruction with the remnant-preserving approach, by classifying them according to stump size.


Eligibility criteria:
inclusion criteria: * aged between 18 - 45 years, * anatomical single-bundle acl reconstruction with antero-medial portal technique using hamstring autograft due to a full-thickness acl tear, * endobutton technique was used for femoral fixation, * has not had any trauma or surgery on the non-operated knee, * patients with a follow-up period of at least 12 months after surgery. exclusion criteria: * fracture of lower extremity, posterior cruciate ligament, inner and outer lateral ligament tears accompanying anterior cruciate ligament tear, * patients who have undergone previous surgery on the targeted knee, * have a revision anterior cruciate ligament reconstruction, * having a history of knee joint arthritis (osteoarthritis, inflammatory arthritis), * have a neurological disease,
prospective, randomized, double blind study comparing iv vs po acetaminophen in patients undergoing lumbar discectomy

Conditions: Pain

Summary: both intravenous and oral acetaminophen have been shown to reduce post-operative pain scores when given preoperatively. this study investigates if there is a difference between the intravenous and the oral forms when given preoperatively to patients undergoing lumbar microdiscectomy. we hypothesize that the intravenous formulation does not improve pain scores or decrease opioid consumption during the first postoperative day compared to the oral formulation.


Eligibility criteria:
inclusion criteria: * single level lumbar micro disk surgery * ages 18-65 exclusion criteria * morbid obesity * prior back surgery * opioid tolerance * pregnancy

Keywords: acetaminophen intravenous oral pain scores opioids
electronic patient reported outcomes in patients with gastrointestinal cancers

Conditions: Gastrointestinal Cancers; Gastrointestinal Cancer Metastatic

Summary: this is a randomized trial of patients with gastrointestinal (gi) cancers treated at university of california, san francisco (ucsf) who are starting a new line of systemic therapy to evaluate the feasibility of electronic patient reported outcome (epro) platform.

primary objectives: i. to evaluate the feasibility of the epro platform by describing the proportion of participants who engage with the epro tool via virtual care chat at least once after enrollment. ii. to investigate the potential differences in health-related quality of life (hrqol) by comparing the change in overall score of euroqol five-dimensional questionnaire (eq-5d) index. secondary objectives: i. to evaluate the degree of engagement with virtual care chat as defined by the proportion of chat modules completed. ii. to measure the potential differences in health-related quality of life (hrqol). iii. to describe the symptom experience of participants in the intervention arm. iv. to evaluate the performance of clinical escalation rules and impact on clinic workflow and efficiency. v. to prospectively validate a risk model predicting emergency department (ed) visits and admissions due to cancer treatment side effects. exploratory objectives: i. to compare unplanned ed visits and hospitalizations between intervention arm and control arm. ii. to compare referral patterns to symptom management clinic. iii. to compare concordance between participant self-reported and provider assigned eastern cooperative oncology group (ecog) performance status.

Eligibility criteria:
inclusion criteria: * age 18 years and older * diagnosis of gastrointestinal cancers: esophageal, gastric, hepatocellular carcinoma, cholangiocarcinoma, pancreatic, neuroendocrine, small intestine, colorectal and anal cancers. * patients can have early stage or advanced cancer and will be starting treatment with new, standard of care infusion therapy regimen at ucsf. * ability to understand study procedures and to comply with them for the entire length of the study. * no limit on prior lines of therapy. * access to smartphone, tablet, or computer with capability to use symptom tracking web site (must have mobile phone number or email address). * willing and able to provide written, signed informed consent in english. * ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it. exclusion criteria: * patients who have already started therapy prior to study enrollment. * patients who are receiving their treatment outside of ucsf. * participation in another clinical trial (therapeutic or non-therapeutic). * patients who are on therapy with oral oncolytics or combination therapy of oral oncolytics and infusional agents. * patients who are non-english speakers.

Keywords: patient reported outcomes hospitalizations emergency department visits
liquid preterm formula versus powdered human milk fortifier in vlbw infants

Conditions: Infant, Very Low Birth Weight

Summary: this study aims to compare the short-term effects on growth and feeding tolerance of a liquid high calorie formula added to human milk versus powdered human milk fortifier in small preterm infants.


Eligibility criteria:
inclusion criteria: * infants between 500 and 1499 grams of birthweight, receiving mother's milk. exclusion criteria: * infants with major congenital anomalies and previous history of gastrointestinal disease.

Keywords: low birth weight neonates premature infants nutrition human milk fortification infant
bariatric surgery and skeletal health

Conditions: Morbid Obesity

Summary: bone loss may occur after bariatric (weight loss) surgery, but standard methods of measuring bone density in obese patients are potentially inaccurate. this study uses quantitative computed tomography to examine changes in bone mineral density after bariatric surgery. we are also studying mechanisms which may explain bone loss after bariatric surgery.


Eligibility criteria:
inclusion criteria: * either scheduled for roux-en-y gastric bypass surgery or enrolled in a lifestyle weight management program exclusion criteria: * weight ≥ than 450 lbs * postmenopausal women * significant heart, kidney, liver, or malignant disease * current disorders known to affect bone * use of medications known to affect bone for more than 7 days in the past 12 months

Keywords: bariatric surgery