Kornimate/medical-research-clean huggingface dataset:
comparison of eus-fnb biopsy techniques of solid pancreatic lesions

Conditions: Pancreatic Neoplasm

Summary: patients with a diagnosis of solid pancreatic lesions evidenced by imaging studies (ct, mri) and who undergo endoscopic ultrasound-guided biopsy will be selected. biopsies will be taken using modified tip needles (fnb) three different methods (capillary by suction, capillary without suction and wet suction). from the results obtained from the pathology service, 3 variables will be assessed; cellularity, blood contamination and suitability for a diagnosis.

eus-baaf procedure the procedure will be performed with a linear echoendoscope (pentax 3.8 eg-3870 utk) and a hitachi hi vision avius ultrasound processor, after deep sedation by the anesthesiology service. baf acquire # 22 needles (boston scientific, malborough, ma) will be used. 3 passes will be made to the tumor, each pass will consist of 10-15 movements of the needle back and forth in a fan within the solid lesion, under complete ultrasound control (esge 2017- gastrointest endoscopy clin n am 22 (2012) 155 -167). doppler will be used to avoid any vascular structure in the path of the needle. the passes will be in three different ways to compare. 1. capillary with suction (puncture with gradual withdrawal of the stylet, applying dry suction with a 10 ml air vacuum syringe after removing the stylet) 2. capillary without suction (puncture with removal of the stylet gradually, without suction after removing the stylet) 3. moist suction (before the puncture, the stylet is removed from the needle and irrigated with 1-2 ml saline solution to replace the air column with liquid, then the solid lesion is punctured and suction is placed with a vacuum syringe of 10 ml of air) the quality of the biopsy will be evaluated by the pathologist independently and without knowing how the sample was obtained.

Eligibility criteria:
inclusion criteria: * over 18 years old * any gender. * patients with solid pancreatic lesions evidenced by ct or mri who do not have a histopathological diagnosis. exclusion criteria: * that no lesion in the pancreas is identified by eus. * pancreatic lesions with a cystic component. * alteration of coagulation parameters (inr\> 1.5, platelets \<50,000 / mm3) or having taken antiplatelet agents or oral anticoagulants one week prior to the biopsy. * history of acute pancreatitis in the last 4 weeks. * pregnant * refusal or inability to sign informed consent
ecg vector determination

Conditions: Epilepsy

Summary: this is a prospective, unblinded, non-randomized, descriptive study designed to collect ecg data.

this is a prospective, unblinded, non-randomized, descriptive study designed to collect ecg data and determine the process for proper generator and lead placement. the study will be conducted in two phases: phase i includes ecg data collection from human subjects; phase ii, the implant instructions for use will be evaluated by cyberonics' clinical engineers based on the activities of five to eight experienced vns surgeons.

Eligibility criteria:
inclusion criteria: 1. at least 12 years old and in general good health for phase i. at least 18 years old and in general good health for phase ii. 2. patients or their guardians must be willing to provide signed informed consent/assent and hipaa authorization. note: patients diagnosed with epilepsy and taking at least 1 antiepileptic medication are desired but not required for the study. exclusion criteria: 1. history of pathologically significant cardiac arrhythmias including but not limited to atrial fibrillation or flutter, chronotropic incompetence, supraventricular tachycardia, ventricular flutter or fibrillation, or implantation of a permanent cardiac pacemaker or defibrillator. 2. currently present existing signs of skin irritation or rash on the left neck or upper left chest as determined by the pi. 3. history of physical adverse reaction to adhesive electrodes.

Keywords: epilepsy ecg device placement
providing cancer care closer to home for patients with multiple myeloma

Conditions: Multiple Myeloma

Summary: there is very limited data on the utilization of national cancer institute comprehensive cancer center (nci-ccc) satellite sites in general. of what is available, most is in regards to providing chemotherapy at facilities closer to patients' home. these "satellite chemotherapy infusion centers", typically community-based treatment locations at community hospitals/facilities, freestanding clinics, or mobile units, are reported to be well liked by patients who utilize their services and reduce their travel times and expenses. in these studies patients still remained in the care of their current provider and site and are required to travel to the site for clinical visits and other appointments. it is currently unknown if patients are willing to transfer their care to a different provider to alleviate travel burden. in addition, although increased travel burden has been lower quality of life in cross-sectional studies, no data exists suggesting that these reducing travel burden can improve these outcomes intra-patient, to the knowledge of the investigators. the patient roles of the multiple myeloma clinical providers at the siteman primary location have grown in recent years. the providers have determined a need to refer some patients to the satellite sites to relieve congestion at the site while also hopefully improving the clinical experience for those patients. this study is a natural experiment of this process.


Eligibility criteria:
eligibility criteria * at least 18 years old * diagnosed with multiple myeloma * receiving care from a provider within the division of oncology at the primary siteman cancer center site * resides within the catchment area of a siteman cancer center satellite site * able to read, speak, and understand english * willing to provide informed consent

Keywords: access to care travel burden financial toxicity patient satisfaction
project early intervention 2000

Conditions: Preterm Infants; Parenting Stress

Summary: the purpose of this study is to examine whether an early intervention program may improve cognitive and behavioral short and longterm outcome in preterm infants.

advances in neonatal medicine has increased the survival of infants with low birth weight. repeatedly it has been documented an increased prevalence of psychological and medical problems in this group of children. frequent psychological problems are intellectual disturbances, language delays, behavior problems like adhd and learning difficulties. usual medical problems are subnormal growth, various illnesses and neuro-developmental problems. the high prevalence of psychological and medical risks makes this group of children target for follow-up assessments and early intervention. the main aim of the project is to investigate whether sensitizing the parents will reduce the incidence of developmental disturbances in a group of low birth weight infants compared to a control group. the study is carried out as a cooperation between the departments of child- and adolescent psychiatry and pediatrics of the university hospital in tromsoe in northern - norway. 140 premature infants with birth weight less than 2000 grams are randomly distributed to an intervention and control group. in addition 70 full term infants are selected to another control. a slightly modified version of the vermont intervention program for low birth weight infants is applied to the infants in the intervention group, where the parents receive one hour of instruction from a special trained neonatal nurse one hour per day the last week before discharge (infant = 37 weeks g.a.). in addition, the parents receive four home visits during the the three first months after discharge. psychological and medical assessments are undertaken at ages: 36 weeks g.a., 6 months, 1, 2 3 5 years corrected for prematurity

Eligibility criteria:
inclusion criteria: * birth weight \< 2000 gram exclusion criteria: * congenital anomalies * non-norwegian speaking mother * triplets

Keywords: preterm infants early intervention outcome behavioral problems parenting stress
assessing the acute effects of diagonal mobilization

Conditions: Aged 14 to 16; Play Football Regularly

Summary: investigating the acute effects of mobilization on these parameters offers innovative insights for the practitioner community and sheds light on the strategy's potential effectiveness in mitigating injury risk. therefore, this study aims to assess the immediate effects of mobilization on static and dynamic balance in young male and female soccer players using a randomized, double-blinded study design.

participants underwent assessment twice: once before the intervention and again afterward. tests included the single leg lend and hold test and the single leg standing test, measured using force plates.

Eligibility criteria:
inclusion criteria: * age between 14 to 16 years old, with regular soccer practice; * absence of lower limb and lumbar spine surgery or injuries within the last 6 months (hip, knee, ankle), no current pain in the hip, knee, or ankle joints, no hypermobility of the lower limb joints, and no history of neurological or connective tissue disorders; * availability for both assessment time points exclusion criteria: -

Keywords: soccer musculoskeletal manipulations postural balance biomechanics
oscillating pep vs autogenic drainage in people with bronchiectasis

Conditions: Bronchiectasis

Summary: in this study, investigating two modes of chest physiotherapy on lung clearance index (lci), 50 patients with bronchiectasis will be randomized to either opep or autogenic drainage.

one of the fundamental treatments in the management of bronchiectasis is airway clearance, which effectively rids the airways of mucus to prevent secondary infection and inflammation. while effective airway clearance is widely accepted as a first line treatment, the choice of airway clearance method is complicated by lacking evidence base. one of the obstacles to establishing evidence of efficacy of an airway clearance technique or device is the limitations in the choice of endpoints. aerobika (trudell medical international, canada) is an oscillating positive expiratory pressure (opep) device, designed and developed for the effective clearance of secretions in people with suppurative lung diseases. it has been tested and found safe and effective in chronic obstructive pulmonary disease (copd) - chronic bronchitis. the lung clearance index (lci) measured by multiple breath washout (mbw) is a measure of ventilation inhomogeneity and has been shown to be a sensitive lung function test in early lung disease. its usefulness has been demonstrated in cystic fibrosis (cf), particularly in children and adults with mild disease. lci has been assessed in bronchiectasis and has been found to be significantly different from normal subjects, and to correlate with forced expiratory volume in 1 second (fev1). the aim of this study is to test the long term effect of daily lung clearance on lci, quality of life and exacerbations using the aerobika opep device versus autogenic drainage (ad) in people with bronchiectasis. 50 patients with confirmed bronchiectasis will be enrolled in this study. participants will be randomized to daily physiotherapy with either aerobika or autogenic drainage. change in lci, measured before and after one month, will be the primary endpoint of this study.

Eligibility criteria:
inclusion criteria: 1. high resolution chest computerized tomography (hrct) during stable disease imaging bronchiectasis in at least 2 lung lobes 2. sputum production during most days of the year 3. stable chronic therapy during last 4 weeks 4. fev1 = 70% predicted or higher on spirometry 5. able to give informed consent or assent 6. age: 18- 80 years exclusion criteria: 1. an exacerbation during last 4 weeks before randomization 2. any change in respiratory medications during the past 4 weeks before randomization 3. a diagnosis of cystic fibrosis 4. a diagnosis of primary ciliary dyskinesia
risk analysis of intensive care mangement on maternal and fetal outcome of severe preeclampsia and eclampsia

Conditions: Hypertensive Disorder of Pregnancy

Summary: laboratory monitoring of patients included serial measurement of complete blood cell count, liver function tests, coagulation profile, and renal function tests. icu management during conduction of the research study included the following: control of convulsions using magensium sulphate. control of blood pressure diastolic blood pressure above 110 mmhg, nifedipine was administered.a plasma volume expansion with saline was used in all women to maintain sufficient intravascular volume. delivery was performed immediately after hemodynamic stabilization and clinical control of general condition .

laboratory monitoring of patients included serial measurement of complete blood cell count, liver function tests, coagulation profile, and renal function tests. icu management included the following: control of convulsions by loading dose of magensium sulphate (4-6g i.v), given over 20 minutes in 100 ml of dextrose then maintenance dose (4-6g) magensium sulphate in 500 cc dextrose given over 8 hours using continuous iv drip.control of blood pressure if diastolic blood pressure above 110 mmhg, nifedipine was administered. delivery was performed immediately after hemodynamic stabilization and clinical control of general condition .termination of gestation decision was based on the the presence of maternal complications, fetal distress.after delivery the patient is retrurned to icu under clinical and careful observation of the following:heart rate, blood pressure,every 15 min,temperature and respiratory rate ,evey 4 hours. duration of admission in the icu was assessed

Eligibility criteria:
inclusion criteria: * women with severe preeclampsia or eclampsia or hellp syndrome admitted to icu exclusion criteria: non eclamptic causes of fits, including hysterical causes and epilepsy -
a phase i, dose-escalation study to assess the safety and drug levels in blood of azd4877 in japanese adult patients

Conditions: Cancer; Tumors; Carcinoma

Summary: the primary purpose of this study is to evaluate the safety and tolerability of azd4877 on a weekly schedule in japanese patients with advanced solid malignancies


Eligibility criteria:
inclusion criteria: * patients diagnosed with solid tumour but which have no standard treatment or did not respond to previous treatments. * patients who usually have mild symptoms capable of walking and light and sedentary work. * patients who can stay in hospital at least during 4 weeks. exclusion criteria: * patients who have received treatment with anti-cancer agent within 4 weeks prior to first dose of study treatment; 6 weeks if the anti-cancer agent is mitomycin. * patients with abnormally low levels of neutrophil count, platelet count, or haemoglobin, indicators of bone marrow function. * patients who received therapeutic radiotherapy at central nervous system within 3 months prior to first dose of study treatment; the other sites within 4 weeks; or local site within 2 weeks.

Keywords: solid tumors solid malignancies
preventing chronic disease: actuaya

Conditions: Healthy Aging

Summary: the purpose of the study is to help older hispanic women to increase physical activity, reach a healthy body weight, increase self-esteem and mood and increase knowledge about chronic diseases such as hypertension, diabetes, and hiv.


Eligibility criteria:
inclusion criteria 1. must self-identify as a hispanic woman 2. must be aged 50 years or older 3. must not already be engaging in exercise for \>150 minutes per week 4. must be able to ambulate without the use of assistive devices 5. must have an intelligent phone ios or android 6. must be willing and able to participate in the informed consent process. exclusion criteria 1. participants that do not meet the above-mentioned criteria. 2. in the opinion of the investigator, have any clinical condition that would make the participant unsuitable to participate. 3. participants who are currently participating in another investigational study. 4. participants that need a medical clearance for exercise based on the american college of sports medicine exercise participation algorithm.
prospective evaluation of an endoscopic ultrasound (eus)-based artificial intelligence to assist in the deployment of lumen apposing metal stents for gallbladder drainage

Conditions: Cholecystitis

Summary: lumen apposing metal stents are now being used to help patients who suffer from cholecystitis (infection of the gallbladder), especially in cases where patients are not candidates for surgery. lumen apposing metal stents are effective for draining the gallbladder, however, placement is technically challenging. scientists have developed an artificial intelligence to aid doctors in the deployment of these stents into the gallbladder. the aim of this study is test the performance of an artificial intelligence in providing physicians accurate information for gallbladder drainage.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * anticipation that patient may undergo endoscopic ultrasound * gallbladder present exclusion criteria: * cholecystectomy * no indication for endoscopic ultrasound
infectious agents exposure : archiving in dental plaque

Conditions: Infection; Dental Calculus

Summary: we are studying the possibility of using dental calculus as a reservoir for the genes of an infectious agent that has infected the patient in previous months; as it is done to highlight climate change in ice samples.

from a sample of people who have had a microbiologically well-documented infection, we will study the possibility after genomic amplification to find, three to 12 months after genetic sequences of the infectious agent in the dental calculus of the person. the people will be recruited according to a large panel of infectious agent (gram + and gram bacterium, mycobacteria, parasite, fungus, dna, rna or retrovirus) and, of course, the presence of dental calculus.

Eligibility criteria:
inclusion criteria: * three months before, having been infected with a documented pathogen * this infection must have been clinically obvious * the patient must have dental calculus exclusion criteria: * to be under 18 years old * to be incapable to consenting * a tartar removal since the infection

Keywords: infection genomic dental calculus
collection of coronavirus covid-19 outbreak samples in new south wales

Conditions: COVID

Summary: the objectives of this study are to characterise immune responses in people with cov-sars-2 infection and use this knowledge to advance vaccine design, treatment options, and diagnostic reagents. eligible participants will include people diagnosed with sars-cov-2 infection, and may include recently returned travellers and non-travellers in the community presenting to tertiary hospital healthcare facilities. recruitment will be opportunistic, and sampling intensity may vary depending on the phase of the outbreak. participants can be enrolled at any timepoint (up to 6 months) following diagnosis of sars-cov-2 infection (covid-19). blood samples and clinical data will be collected.


Eligibility criteria:
inclusion criteria: * main cohort 1. diagnosed with cov-sars-2 infection 2. 16 years of age or older 3. have provided informed consent paediatric cohort 1. diagnosed with cov-sars-2 infection 2. less than 16 years of age 3. informed consent provided by parent or caregiver exclusion criteria: main cohort 1. 15 years of age or younger 2. inability or unwillingness to provide informed consent or abide by the requirements of the study paediatric cohort 1. 16 years of age or older 2. inability or unwillingness of parent or caregiver to provide informed consent or abide by the requirements of the study -
shoulder pain and its effects on joint position, strength, tactical sensory and posture in hemiplegia

Conditions: Hemiplegic Shoulder Pain

Summary: the main purpose of this study is to reveal the effects of shoulder pain in chronic hemiplegic patients with a more comprehensive and holistic perspective through evaluation and correlation methods. it is thought that these evaluations can make significant contributions to the understanding of the etiology and treatment of post-stroke shoulder pain. the focus of the study is to deeply examine the effects of shoulder pain on joint position sense, postural control, tactile sense and muscle strength in chronic hemiplegic patients.

this study aims to investigate the effects of shoulder pain on joint position sense, postural control, tactile sensation, and muscle strength in chronic hemiplegic stroke patients. designed as a cross-sectional descriptive study, it involved participants divided into two groups based on the presence or absence of shoulder pain. the assessments included joint position sense , postural control , tactile sensation , gross grip strength, and pinch grip strength . the findings of this study are expected to contribute to clinical practice by aiding in the development of more effective interventions for managing post-stroke shoulder pain. additionally, it aims to serve as a foundation for future comprehensive research, emphasizing the critical role of addressing pain in the rehabilitation process.

Eligibility criteria:
inclusion criteria: * at least 3 months post-stroke, diagnosis of hemiplegia after stroke, aged 18 or older, having cognitive abilities and cooperation required to fulfill the study requirements, and willingness to participate in the study. exclusion criteria: * mini mental state examination (mmse) score \< 24, patients with aphasia, major neurological or rheumatological diseases affecting the musculoskeletal system other than stroke, and patients who had surgery on the affected shoulder prior to the stroke diagnosis.

Keywords: stroke pain postural control sensation muscle strength
study of the role of soluble inhibitor of interleukin 22, interleukin 22 binding protein (il-22bp), in chronic inflammatory bowel disease

Conditions: Inflammatory Bowel Disease

Summary: il-22 is an il-10 family cytokine that plays major actions to increase intestinal epithelial barrier function and regeneration during experimental colitis. il-22 binding protein is a small, soluble, and secreted protein potently inhibiting il-22 actions through preventing the binding with il-22 recepteur. this study aims at characterizing how il-22 binding protein is regulated in inflammatory bowel disease to better understand the way il-22 acts on epithelial cells during flares of the disease.


Eligibility criteria:
inclusion criteria 1. crohn's disease or ulcerative colitis 2. healthy controls paired for age and sex 3. samples availability in the biobank 4. signed consent 5. no (immune mediated inflammatory disorders other than inflammatory bowel disease 6. no other conditions predicted or known to affect il-22/il-22 recepteur /il-22 binding protein regulation 7. availability of clinical data 8. age \>18 y.o. 9. no pregnancy