Kornimate/medical-research-clean huggingface dataset:
clinical evaluation of three dental adhesive systems in class v restorations

Conditions: Dental Caries

Summary: the purpose of this study is to compare the clinical performance of three dental adhesive systems used to bond class v cavity fillings in adult teeth.


Eligibility criteria:
inclusion criteria: * must be at least 19 years of age * must have at least 3 qualifying noncarious class v lesions of appropriate depth * must be willing to sign consent form * must be willing and able to return to uab clinic for 4 study appointments * must be in good medical health and able to tolerate dental procedures exclusion criteria: * current participation in other restorative product studies * severe salivary gland dysfunction * rampant caries (cavities) * chronic periodontitis (gum disease) * known allergies to the study materials * unacceptable level of oral hygiene * inability or unwillingness to attend study appointments
motivational interviewing in women's pelvic wellness education

Conditions: Pelvic Floor Disorders; Urinary Incontinence (UI); Pelvic Prolapse Conditions

Summary: this pilot study will assess the feasibility and acceptability of an educational workshop on pelvic floor disorders and its potential impact on decisional conflict.

pelvic floor disorders can significantly affect a woman's quality of life, yet many feel uncomfortable openly discussing these topics. treatments include lifestyle modification, medications, and/or surgery. "decisional conflict" arises when patients have difficulty choosing between several viable treatment options. factors contributing to decisional conflict include biased information, poor peer support, and unaddressed fears. effective counselling may help address these factors. there are few studies on how decision coaching can help women with prolapse and incontinence reach a satisfactory decision about treatment. this study aims to use the principals of shared decision making to address decisional conflict surrounding treatment for pelvic floor disorders. specifically, the investigators will evaluate the feasibility and acceptability of small group workshops on pelvic organ prolapse and urinary incontinence led by a nurse continence advisor and a psychologist (decision coach). results of this study will inform future development of interdisciplinary, patient-centered approaches to enhanced decision making in women's health.

Eligibility criteria:
inclusion criteria: * women ages \>18 years old * urinary incontinence and/or pelvic organ prolapse * first visit with urogynecologist exclusion criteria: * anal incontinence * previous pelvic radiation therapy * requirement for a substitute decision maker * inability to attend the workshop * unwilling to attend an english-language workshop * unwilling to complete english-language surveys

Keywords: decisional aid workshops urinary incontinence pelvic organ prolapse pelvic floor dysfunction decisional conflict
evaluation of prognosis factors of neurological evolution in cardiac arrest

Conditions: Cardio Respiratory Arrest

Summary: with the repercussion of 55 cases eachyear for 100 000 inhabitants in france, cardio respiratory arrest is a public health issue. the goal of this study is to evaluate the pupillary light reflex measured by the dimension of the pupil (diameter) as a prognosis factor neurological evolution in post cardiac arrest. by participating to this study, the patient get the same tratments and exams than in a usual managing cares. in addition of these events, the pupillary light reflex is studied as soon as the patient is accepted in the department, and then on the second day. currently, the evaluation of the neurological becoming rely on a multimodal clinical and paraclinical approach. the study of the pupillary light reflex measured by the diameter of the pupil could be a prognosis factor of neurological evolution for patients in post cardiac arrest, so a reliable and available prognosis marker in patient care. the goal of this study is to evaluate the pupillary light reflex (rpm), measured by the diameter of the pupil as a prognosis factor of neurological evaluation of admitted patients after a cardiac arrest. principal criteria of judgement is the percentage of the pupillary light reflex variation measured with neurolight®, compared between two groups.


Eligibility criteria:
inclusion criteria: * both gender * entry in resuscitation after a cardiac arrest intra or extra-hospital * resumption of a spontaneous cardiac activity * affiliation to a social security system exclusion criteria: * refusal from patient or his family * age under 18 years * pregnant women * previous neurological damages * persons deprived of liberty by judicial or administrative decision

Keywords: pupillary light reflex cardio respiratory arrest
study to determine effects of vesicare on return to continence post- radical prostatectomy

Conditions: Incontinence

Summary: prostate cancer is the most common non-cutaneous malignancy in men and is the 2nd leading cause of death from cancer in men. radical prostatectomy is one of the treatment options available for organ-confined disease. over 100,000 radical prostatectomies cases (total removal of the cancerous prostate by surgery) are performed in the united states yearly. unfortunately nearly all of the men undergoing surgery report diminished quality of life (qol) scores due in part due to a postoperative incontinence which may require the use of multiple urinary pads per day. many of these men also report debilitating irritative voiding symptoms of urinary urgency and frequency, and have overall decreased urinary satisfaction scores. abatement of these symptoms can take up to one year in men, and in 5-20% of patients symptoms may persist for longer periods. our recent published findings suggest that instability in the bladder muscle is likely an underlying etiology in postoperative urinary incontinence. this 'detrusor muscle' instability results in excess contractions of the urinary bladder ('urgency to urinate'), and can result in the feeling of needing to urinate more frequently. consistent with this hypothesis of detrusor muscle instability, men with postoperative dribbling had more complaints with urgency, frequency and bother scores when queried with validated questionnaires. we suspect that a transient bladder muscle contraction may overcome the urinary sphincter valve resistance and result in the patient's dribbling of urine. by treating the bladder muscle instability, we expect improved postoperative continence and improved quality of life in patients after undergoing surgery for total removal of a cancerous prostate. this pilot study will assess the statistical requirements for the number of subjects needed for a fully 'powered' randomized prospective study to fully evaluate whether medications such as solifenacin significantly improve patients' quality of urinary life and improve postoperative urinary incontinence after surgery.


Eligibility criteria:
inclusion criteria: * men diagnosed with prostate cancer undergoing robotic radical prostatectomy * incontinence * obesity * large prostate weight * mild and severe aua symptom scores * urinary bother exclusion criteria: * contra-indication to solifenacin * narrow angle glaucoma * hepatic impairment * renal impairment * cyp3a4 inhibitors (e.g. ketoconazole) * gastric retention (delayed or slow emptying of the stomach)

Keywords: incontinence robotic prostatectomy
effectiveness of rebound therapy in parkinson's patients

Conditions: Parkinson Disease

Summary: today, physiotherapy approaches in parkinson's disease (pd) form the basis of optimal treatment together with medical and surgical treatment. it is stated that various rehabilitation interventions may be effective in the field of physiotherapy. the frequently preferred among these rehabilitation interventions is the conventional treatment approach. in the conventional treatment, various exercises are preferred to improve balance and walking, as well as stretching and strengthening. on the other hand, rebound therapy require strong integration of the neuromuscular system and provide more active use of lower extremity muscle strength. rebound therapy have been shown to be effective in improving balance in many neurological disease groups, but there is very little study on rebound therapy in pd. it was shown that rebound therapy improve proprioceptive sense, joint range of motion and quality of life. on the other hand, no study has been found showing its effect on balance and walking. therefore, there is a need to investigate the effectiveness of rebound therapy on balance and walking.

this study is a randomized controlled study. the patients will be randomly divided into two groups as rebound and control. the rebound group will perform exercises on a trampoline, consisting of 15 minutes of trunk and extremity stretching, 10 minutes of walking, and approximately 30 minutes of task-oriented exercises, twice a week for six weeks. while the control group will follow the same program as the rebound group, they will only perform task-oriented exercises on a stable surface, unlike the rebound group. as the outcome measures, disease severity and disability, balance, and gait performance will be evaluated.

Eligibility criteria:
inclusion criteria: * 40-80 years of age * having diagnosed with "parkinson's disease" by a specialist physician * having between 1-3 stages according to the hoehn and yahr scale * mini-mental test score more than or equal 24 exclusion criteria: - any orthopedic, vision, hearing, cardiovascular, or perception problems that may affect the research results

Keywords: parkinson's disease rebound therapy task oriented training balance and walking performance
probiotics on intestinal inflammation in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: cystic fibrosis (cf) is a complex systemic disease that mainly involves the respiratory and gastrointestinal (gi) tracts. the polymicrobial community composition of respiratory and gi tracts is influenced by both genetic and environmental factors. children with cf may harbor an abnormal intestinal microflora, because of altered cystic fibrosis transmembrane conductance regulator (cftr) function and heavy drug load (antibiotics, pancreatic enzymes and acid suppressors). the investigators previously demonstrated that intestinal inflammation is highly frequent in cf children, being a major feature of intestinal involvement. in addition, specific probiotics significantly improved airway and gi inflammation in a preliminary trial. the aim of the study is to characterize intestinal and respiratory microflora in cf patients and to investigate the effects of daily lactobacillus gg (lgg) supplementation on both gi and airway microflora and the eventual relationship between probiotic assumption and clinical and inflammation markers. the aim is to study the effect of microflora modification on intestinal and extraintestinal inflammation to eventually improve the quality of life of cf patients, who often suffer from intestinal and respiratory progressive disease, through a non invasive intervention consisting in the supplementation of probiotic bacteria.


Eligibility criteria:
inclusion criteria: * diagnosis of cf documented by sweat chloride test over 60 mmol/l and confirmed by genotype analysis with the presence of f508del/f508del or f508del/other; * boys and girls between 2 and 16 years of age; * clinical stability at enrolment, defined as no clinical evidence of acute exacerbation, no modifications in the therapeutic regimen and no hospitalization in the last 2 weeks; * pancreatic insufficiency; * basal forced expiratory volume 1 second (fev1) above 50% of predicted value. exclusion criteria * colonization of respiratory tract with burkholderia cepacia spp.; * steroid therapy within one month before enrolment; * pregnancy and fertile women taking oral contraceptives; * parenteral or oral antibiotics therapy within 2 weeks before enrolment; * regular assumption of probiotics; * regular assumption of azythromycin.

Keywords: intestinal inflammation intestinal microflora children
calcium supplements strategy for kidney stones prevention in crohn's patients

Conditions: Kidney Calculi; Crohn's Disease

Summary: hospitalization for kidney stones in the inflammatory bowel disease (ibd) population is common, particularly among crohn's patients who had a small bowel resection. this patient population experiences a lifetime occurrence of kidney stone formation as high as 25% accompanied with a high rate of recurrence (the typical rate of stone formation is \~10% in the non ibd population). giving oral calcium is used to bind oxalate in the intestine in an attempt to reduce the amount of oxalate that is absorbed into the body and to reduce urinary oxalate levels. however, there are no defined guidelines for the optimum dosing of calcium. this study's primary objective is to scientifically define an appropriate range of calcium supplementation that reduce the level of oxalate found in the urine of patients living with inflammatory bowel disease.

the primary objective of this study is to establish optimal oral calcium supplementation in crohn's patients who have had an ileal bowel resection. this population is at high risk for calcium oxalate kidney stones, a direct consequence of extensive gut malabsorption and enteric hyperoxaluria. the benefit of providing oral calcium in this patient population (as a means to reduce intestinal oxalate absorption) is known, however, there are no appropriate targets for calcium dosing, which is presently performed empirically or not at all. our goal is to establish simple, safe and practical guidelines for calcium supplementation.

Eligibility criteria:
inclusion criteria: 1. a pathologically confirmed diagnosis of crohn's disease 2. prior ileal resection with an intact colon (surgery\>6 months preceding involvement in study) 3. hyperoxaluria (defined as\> 48 mg (\>0.5 mmol) per 24 hour urine samples. * patients will not be excluded if they are known kidney stone formers. exclusion criteria: 1. current pregnancy 2. patient's without baseline hyperoxaluria (defined as \>48 mg or 0.5mmol per 24 hour urine samples) 3. patients in renal failure assessed by a gfr \< 60 4. inability to provide informed consent 5. active cancer 6. hyperparathyroidism 7. hyperphosphatemia 8. \<19 years of age
phase 1 to investigate safety, tolerability, pk/pk of j2h-1702 in healthy males

Conditions: Non-alcoholic Steatohepatitis

Summary: 1. research purpose: to evaluate the safety, tolerability, pharmacokinetic/pharmacodynamic properties of j2h-1702 (a candidate for treatment of non-alcoholic steatohepatitis) in healthy men. 2. design: a dose block-randomized, double-blind, placebo controlled, single- and multiple dosing, dose-escalation phase 1 clinical trial

subjects in all dose groups will be randomized to the study group (j2h-1702 group) and the control group (placebo group) in a 8:2 ratio. adverse event (ae) collection, physical examination, vital signs, ecg, clinical laboratory tests, etc. will be performed to assess the safety and tolerability, and blood and urine sampling will be performed to assess the pk/pd characteristics. in addition, blood sampling for mass cytometry (multiple administration study) and baseline fibroscan will be performed for the exploratory evaluation.

Eligibility criteria:
inclusion criteria: 1. a healthy male adult within the range of 19 to 45 years old 2. bmi=18.0\~27.0kg/m2 (body mass index, bmi) 3. a subject confirmed to be clinically healthy based on the medical history, physical examination, vitals signs, ecg, and appropriate clinical laboratory tests 4. a subject who his spouse or partner agrees to use dual contraceptive methods and not to donate sperms 5. a subject who has voluntarily agree to participate in the study exclusion criteria: 1. a subject who had or has the disease corresponding to clinically significant liver, etc. 2. a subject with a history of gastrointestinal diseases or surgery 3. a subject who has a history of clinically significant hypersensitivity to drugs containing 11β-hsd1 inhibitor 4. a subject who has genetic problems such as galactose intolerance, lap galactose intolerance, lap lactase deficiencies, or glucose ∙galactose malabsorptivity, etc. 5. one who has drug abuse and one who is positive response in urine drug screening tests 6. a subject with abnormal vital signs at the screening visit 7. a subject who has participated in another clinical trial or bioequivalence test 8. a subject who donated whole blood or the ingredient, or received blood transfusion 9. a subject who took drug metabolizing enzyme-inducing and inhibitory drugs 10. a subject who consumes grapefruit/caffeine-containing food 11. a subject who took any prescription drug or herbal medicine or took any over the counter drug (otc) 12. high caffeine intaker, high alcohol intaker or excessive smoker 13. a subject who cannot eat meals provided by the clinical trial institution. 14. a subject who participated in this trial and were administered the investigational product. 15. a subject who is positive for serum test 16. a subject who the investigator deems inappropriate for this clinical trial.
copd: a multi-center supervised tele-rehabilitation study

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease(copd) patients could benefit from pulmonary rehabilitation(pr) in better managing of the disease and its symptoms and in avoiding future relapses and hospitalizations. however, due to a large number of drop outs from pr, lack of professionals, and the (corona virus disease 2019) covid-19 epidemic, the pr has been underutilized, leading to a need for investigation of updated forms. the study aims to investigate the effects of a home-based pr program using minimal accessories, facilitated with wearable activity trackers and smartphones.


Eligibility criteria:
participants with a clinical diagnosis of and meeting the following criteria are eligible: 1. diagnosis of copd of global initiative for chronic obstructive lung disease (gold) ii-iv and without acute exacerbation within the last 2 weeks. 2. motivated for participating in the project (and acceptance of randomization) 3. sufficient mobility to attend pr exclusion criteria: 1. certain comorbidities (e.g. unstable coronary complications) 2. severe cognitive disabilities (e.g. dementia) 3. inability to cope with the program because of severe hearing or visual disorder.

Keywords: copd pulmonary rehabilitation tele-rehabilitation
(botox) mechanisms of action in altering the molecular environment in which pain fibers exist

Conditions: Migraine

Summary: to compare botox-treated and botox-untreated symptomatic tissues (defined as areas where the head hurts and the pain is felt) of chronic migraine (cm) patients using molecular studies.

eligible patients for migraine surgery will be injected unilaterally with botox prior to surgery. the effects of botox on tissues will be evaluated.

Eligibility criteria:
inclusion criteria: * age 18-65 years * diagnosis of chronic migraine consistent with international classification of headache disorders (ichd-iii) criteria, with a history of bilateral headache pain and chronic tenderness in neck muscles * patient is capable and willing to provide informed consent * female subjects of child bearing potential must have a negative pregnancy test at enrollment and agree to remain abstinent or use acceptable methods of birth control (i.e., hormonal contraceptives, inrauterine device, diaphragm with spermicide, cervical cap or sponge, condoms or partner has had a vasectomy) for three months following injections of botox * patients referred by their primary neurologist to the study surgeon and who are determined to be candidates for surgical decompression of extracranial sensory nerves. * patient agrees to abstain from protocol-specific excluded medications beginning 14 days prior to the decompression surgery. exclusion criteria: * patient has hypersensitivity reactions or other intolerance to botox * patient is pregnant or trying to become pregnant with the timeframe of the study. * infection at proposed injection sites.

Keywords: chronic migraine trigeminal neuralgia migraine surgery nerve decompression
electronic intervention to chronic opioid therapy

Conditions: Chronic Opioid Therapy

Summary: this pilot study will attempt to apply an electronic chart intervention to improve safety for patients on chronic opioid medications.


Eligibility criteria:
inclusion criteria: * patients prescribed long-term opioid therapy of doses greater than 90 morphine equivalent daily dose (medd) exclusion criteria: * patients prescribed short-term opioid medications for acute pain (less than a 90-day supply over the past 120 days), sublingual buprenorphine, methadone maintenance for opioid use disorder or with oncology or palliative care diagnoses will be excluded.
comparison of treatment alternatives for myofascial pain causing central sensitization

Conditions: Myofacial Pain; Central Sensitization

Summary: myofascial pain is a regional muscle pain condition characterized by hard local areas and tender bands, known for the presence of trigger points in muscle tissue. the treatment is to eliminate the etiologic factor. regular exercise is recommended to relieve the trigger points. occlusal splints, considered the gold standard in the treatment of temporomandibular joint disorders, are used to manage and control symptoms. in this study, patients between the ages of 18-45 years who applied to çukurova university faculty of dentistry, department of prosthodontics with the complaint of myofascial pain and scored above 40 on the central sensitization scale will be taken as a sample.

patients scoring 40 and above on the csi scale will be evaluated according to the diagnostic criteria - diagnostic criteria for temporomandibular disorders (dc-tmd) and four groups will be formed including the control group diagnosed with myofascial pain. bilateral masseter and temporal muscle thicknesses of all participants will be measured and recorded with a clarius l7 ( vancouver, canada) ultrasound device. the control group will be trained and asked to comply with the training until the study is completed. the participants in the first experimental group will use occlusal splints that are digitally designed by transferring the impressions taken with intraoral scanner (trios5, 3shape trios a/s, copenhagen, denmark) to the exocad design program and printed on three-dimensional printers. participants in the second experimental group will be given home-based exercise programs prepared by physical therapists. participants in the third experimental group will use occlusal splints digitally designed by transferring the impressions taken with intraoral scans (trios5, 3shape trios a/s, copenhagen, denmark) to the exocad design program and printed on three-dimensional printers and will be given home-based exercise programs prepared by physical therapists. muscle thickness measurements will be repeated at week 2, week 4, week 8 of the treatments and pain report forms will be filled out. as of week 8, treatments will be terminated and patients will be called to the clinic for control visits at week 12 and muscle thickness measurements will be repeated and pain report forms will be filled.

Eligibility criteria:
inclusion criteria: * examination of bilateral masseter and temporal muscles for the presence of trigger points * score above 40 on the csi scale exclusion criteria: * noise during jaw movements (click, crepitation) * presence of systemic diseases involving joints (rheumatoid arthritis) * having received treatment for joint discomfort in the last six months (botox, splinting, exercise, counseling) * use of drugs affecting the central system (gabapentin, pregabalin, tricyclic antidepressants)

Keywords: central sensitization myofacial pain stabilization splints muscle thickness muscle exercises