Kornimate/medical-research-clean huggingface dataset:
carbon black tattoo in colon cancer

Conditions: Endoscopic Tattoo of Suspected Colon Cancer

Summary: the study is designed to elucidate whether carbon black suspension endoscopic tattoo enhances visibility of lymph nodes or tumor tissue on dissection of colonic surgical specimen, thereby making improvement in staging defined as better ptnm stage via better visualisation of carbon marked metastatic or sentinel lymph nodes or marked primary tumor or adjacent tissues.

other objectives are: * to assess intraoperative visibility of carbon black tattoo in the tumor region and surrounding tissues * to assess microscopic distribution of carbon ink in the layers of the colonic wall and adjacent tissues * to assess complications related to carbon black tattoo procedure like microscopic fibrosis, micro- or macroscopic scarring, inflammatory reactions * to assess long-term effects of ink injections on control endoscopies at 6 and 12 months * to assess dissection time in tattooed-non tattooed lymphatic tissues

Eligibility criteria:
inclusion criteria: * male or female aged 18 years or above undergoing colonoscopy for suspected colonic malignancy * participant is able to give informed consent for participation in the study * patient is presumably selected for surgery within 30 days following tattoo injection exclusion criteria: * patients under the age of 18 * patients unable to give informed consent or ineligible for surgery * tumor in the coecum dome or in the rectum (\<15 cm) * known allergy to suspension ingredients
randomized clinical trial to compare a regimen of trimethoprim-sulfamethoxazole plus rifampicin with a regimen of linezolid in the treatment of methicillin-resistant staphylococcus aureus (mrsa) infection

Conditions: MRSA Infection

Summary: mrsa infections often require systemic antibiotic therapy and represent an important healthcare burden. currently available treatment options are either only available in parenteral form (vancomycin) or expensive (linezolid). thus, there is an urgent, unmet need to better investigate in-expensive but highly active alternatives to currently recommended standard treatment options. the purpose of the proposed study is to test the hypothesis that a combination of tmp-smx and rifampicin is not inferior to linezolid for treatment of mrsa infections.


Eligibility criteria:
inclusion criteria: 1. age \> 18 years 2. patients with clinical signs and symptoms of mrsa-related infection 3. culture of mrsa (predominant microorganism in culture) susceptible to all of the following: * tmp-smx * rifampicin * linezolid 4. patient must give written informed consent to participate in the study. exclusion criteria: 1. women who are pregnant or nursing 2. women who refuse to substitute oral contraception during treatment 3. known or suspected hypersensitivity to linezolid, tmp-smx or rifampicin 4. clinical or laboratory evidence of significant impairment of hepatic function, as demonstrated by any of the following criteria: * bilirubin \> 3 x upper limit of normal range * ast or alt \> 5 x upper limit of normal range * acute hepatitis or proven liver cirrhosis by liver histology 5. treatment with other antimicrobials with activity against mrsa for \> 72 hours prior to study inclusion 6. patients with a high probability of death within the week following study entry 7. patients who, in the opinion of the investigator, cannot be relied upon for post-therapy follow-up 8. patients requiring alternative antibiotic therapy with anti-mrsa activity. however, if another antibiotic treatment without antistaphylococcal activity is necessary, the patient is acceptable for randomization. in that sense, the use of aztreonam (against gram negative microorganisms) or metronidazole (against anaerobes) is allowed 9. hemodialyzed patients 10. history of pheochromocytoma, carcinoid syndrome, untreated hyperthyroidism, uncontrolled hypertension, or patients receiving serotonin uptake inhibitors 11. severe thrombocytopenia (\< 50.000 platelets) 12. left-sided endocarditis with a poor prognosis (patients aged over 50; cerebral embolism) 13. chronic osteomyelitis without surgical debridement; superinfected indwelling foreign body, deliberately kept in place 14. patients with severe sepsis or septic shock due to mrsa bacteremia 15. patients who receive any of the following drugs, which cannot be substituted or temporarily withdrawn: adrenergic and serotonergic agents, tramadol, pethidine, duloxetine, venlafaxine, milnacipran, sibutramine, chlorpheniramine, brompheniramine, cyproheptadine, citalopram, and paroxetine.

Keywords: staphylococcal infection
the use of virtual reality for the treatment of visual vertigo.

Conditions: Treatment of Visual Vertigo

Summary: this study investigates the use of virtual environments presented on a head mounted display for the rehabilitation of those suffering with visual vertigo. the control group and treatment groups will be presented with two different sets of environments and be given the same head and eye exercises to complete within the environment. they will also be provided with at home exercises to complete.

visual vertigo occurs after the balance system suffers damage (e.g after a viral infection such as labyrinthitis). this causes an over-reliance on the eyes to maintain balance which causes disorientation in busy environments such as the supermarket. the treatment involves trying to desensitise the individual to visually stimulating situations. further head and eye exercises are completed alongside the exposure to overcome the damage done to the balance system.

Eligibility criteria:
inclusion criteria: * those who have been diagnosed with visual vertigo and have scored a significant level on the situational characteristic questionnaire (over 0.74 as per pavlou et al., 2006). exclusion criteria: * those with or under investigation for epilepsy. * those who have been determined to have no or limited balance function in both ears. * those with reduced visual acuity that will leave them unable to view the 3d effects of the head mounted display. * those with severe mental health disorders e.g. psychosis, paranoid disorders, bipolar disorder or a history of substance abuse. * severe neck pain/ restricted movement. * previous treatment for visual vertigo. * those with an fluctuating vestibular disorder such as ménière's disease or vestibular migraine. * those with untreated benign paroxymal positional vertigo (bppv). * those with a significant brain injury, or head injury that results in a central vestibular disorder. * those with an arrhythmia.
establishment and validation of a risk prediction model for long-term low vision after vitrectomy in pdr patients

Conditions: Proliferative Diabetic Retinopathy; Pars Plana Vitrectomy; Risk Prediction Model

Summary: diabetic retinopathy (dr) is the main cause of blindness among working-age adults in the world. proliferative diabetic retinopathy (pdr) is the severe stage of dr, which is characterized by neovascularization of the retina. vitreous hemorrhage and traction retinal detachment caused by pdr often require vitrectomy. the purpose of vitrectomy is to remove vitreous hemorrhage, peel off the preretinal proliferative membrane and help restore the retina. with the deepening of people's understanding of diabetes and the development and application of various hypoglycemic drugs, the life expectancy of patients with diabetes continues to prolong. therefore, the goal of vitrectomy in patients with dr is not only to prevent blindness, but also to maintain good vision for a long time. the purpose of this study is to analyze the risk factors related to the occurrence of long-term low vision postoperatively and establish a risk prediction model, which can help patients adjust their psychological expectations reasonably and promote communication between doctors and patients.


Eligibility criteria:
inclusion criteria: * voluntary and able to sign an informed consent form * age ≥18 years * documented diagnosis of diabetes mellitus (type i or type ii diabetes) defined by the american diabetes association or world health organization criteria. * unabsorbed vitreous hemorrhage lasted for more than 2 weeks, with or without tractional retinal detachment examen by slit lamp, b-ultrasound and fundus color photography. exclusion criteria: * patients with less than 12 months of follow-up * previous intraocular surgery (eg. corneal transplantation, glaucoma filtering, vitrectomy, except cataract surgery) * complicated with other retinal diseases * underwent surgery (eg. intravitreal injection, cataract surgery) of the study eye within 3 months * lack of medical records.
supporting transitions to primary care among under-resourced, postpartum women (step-up)

Conditions: Gestational Diabetes Mellitus; Hypertension in Pregnancy; Dysglycemia

Summary: step-up will promote linkage to primary care and ongoing chronic disease evaluation for postpartum women with prior gestational diabetes mellitus (gdm) and/or hypertensive disorders of pregnancy (hdp).

step-up will promote linkage to primary care and ongoing chronic disease evaluation for postpartum women with prior gestational diabetes mellitus (gdm) and/or hypertensive disorders of pregnancy (hdp) by promoting: 1. counseling and referral to primary care, during ob visits, via electronic health record (ehr)-based clinical decision support (cds) 2. dysglycemia testing for women with prior gdm, prompted via cds during both ob and primary care visits 3. dissemination of understandable information on future risk and the need for ongoing evaluation generated automatically via the ehr and printed for patients with after-visit summaries (avs) 4. motivational messaging and reminders supporting transitions of care delivered directly to patients via short message service (sms) text messages 5. individualized outreach and support for those who need additional help arranging a primary care visit we will utilize a stepped wedge design to achieve the study's specific aims, which are to: aim 1 test the effectiveness of step-up, compared with usual care, to improve patient: 1) knowledge of reproductive risks associated with t2dm and recommended self-care activities; 2) engage in self-care behaviors, including diet, physical activity, adherence to diabetes medications, and use of folic acid and most or moderately effective contraception, when indicated; and 3) clinical measures, including hemoglobin a1c, blood pressure, and ldl cholesterol. aim 2 investigate the heterogeneity of step-up intervention effects by patients' race, ethnicity, and language. aim 3 assess the reach, adoption, implementation, maintenance and costs of step-up components.

Eligibility criteria:
inclusion criteria: * delivered during an accrual period, * had a chart diagnosis during their index pregnancy of gdm and/or hdp, * attended at least 1 prenatal care visit at a study site in the 6 months prior to delivery, * speak english or spanish, * age 18 or older
modification of risk factors associated with knee injury in netball

Conditions: Knee Injuries

Summary: noncontact knee injuries are a concern in netball. as such, it is important to devise appropriate injury prevention programs that players will complete to reduce the risk of injury. previous research suggests that the most common situation of noncontact knee injury in netball involves a stiff landing or apparent knee valgus collapse, trunk rotation, and lateral flexion. therefore, the aim of this study is to investigate the effect of a neuromuscular training program on biomechanical risk factors during a netball-specific landing.


Eligibility criteria:
inclusion criteria: * female * 18-45 years * no history of lower limb injury in the last 6 months * no history of concussion in the last 6 months * no history of any knee surgery * currently playing recreational netball at least once per week exclusion criteria: * male * under 18 years or over 45 years of age * suffered from a lower limb injury in the last 6 months * suffered from concussion in the last 6 months * any history of knee surgery * not currently playing recreational netball at least once per week
relationship of deep cervical flexor muscle endurance with neck position sense and body balance

Conditions: Neck Pain

Summary: the aims of this research are to investigate relationship of deep cervical flexor muscle endurance with neck position sense and body balance in non-specific chronic neck pain, and to compare the results with healthy individuals.

the investigation will be included 2 groups which include 30 individuals with non-specific chronic neck pain and 30 healthy individuals. in evaluation of participants, endurance of deep cervical flexor muscles will be measured using stabilizer pressure biofeedback unit with cranio-cervical flexion test. pressure rise which increases from 20 mmhg to 30 mmhg with 2 mmhg increments will be performed in 5 stages. there are 10 seconds contractions at every stage and these contractions will be made 10 times. endurance will be calculated by the cumulative performance index with the information obtained from this test. neck position sense of 6-direction (flexion, extension, right-left lateral flexion and right-left rotation) will be measured by crom device (cervical range of motion device). joint position error will be calculated by taking the average of the absolute angular difference by 3 trial for each direction. body balace will be measured by balance master system. modified clinical test of sensory interaction balance (mctsib), limits of stability (los), rhythmic weight shift (rws), unilateral stance (us), walk across (wa) and step/quick turn (sqt) will be performed.

Eligibility criteria:
inclusion criteria: * non-specific chronic neck pain for at least 3 months * neck pain is at most 7/10 according to vas exclusion criteria: * musculoskeletal treatment for neck complaints or balance within the last 3 months * musculoskeletal disease that may affect balance * spine, upper or lower limb fractures or surgical history * diagnosis of vestibular disorder * diagnosis of neurological or systemic musculoskeletal disease * pregnancy

Keywords: chronic neck pain balance master joint position error endurance
study to assess safety & immunogenicity of gsk biologicals' dtpa/hib vaccine vs separate administration of dtpa and hib.

Conditions: Tetanus; Diphtheria; Acellular Pertussis

Summary: this study will compare gsk biologicals' dtpa/hib vaccine to separately administered dtpa and hib vaccines in chinese infants 3, 4 \& 5 months of age, in terms of safety and immunogenicity.


Eligibility criteria:
inclusion criteria: * a male or female between, and including, 90 and 120 days of age at the time of the first vaccination, * written informed consent obtained from the parent or guardian of the subject exclusion criteria: * subjects with known exposure to diphtheria, tetanus, pertussis and/or haemophilus influenzae disease can not participate, * subjects who have received previous vaccination against diphtheria, tetanus, acellular pertussis and/or haemophilus influenzae type b diseases can not participate.
wholegrain cereal diet and insulin sensitivity

Conditions: Metabolic Syndrome

Summary: a diet with the multiple beneficial characteristics of whole grains and, more in general, of "healthy cereals" favorably influences glucose and insulin metabolism in subjects with metabolic syndrome. therefore, the aim of the study is to evaluate the long term effects of a diet containing "healthy cereals" versus a control diet, on glucose and insulin metabolism in subjects with metabolic syndrome.


Eligibility criteria:
inclusion criteria: * subjects with at least three of the following criteria of metabolic syndrome according to atpiii-ncep criteria: 1. waist circumference \>102 for men and 88 for women, 2. fasting total serum triacyglycerol concentration \>1.7 mmol/l, 3. fasting hdl cholesterol \<1.0 mmol/l for men or \<1.3 mmol/l for women, 4. ifg (plasma glucose between 6.1 and 6.9 mmol/l) or 5. blood pressure \>130/85 mmhg or use of blood pressure medication * hypertension in stable control (bp \<135/80 mmhg) by means of drugs, which will not be allowed to be changed during the study * absence of main cardiovascular events (ima, ictus) exclusion criteria: * diabetes mellitus diagnosed according to history of diabetes or blood glucose ≥ 200 mg/dl (11.1 mmol/l) 2 hours after a 75 g oral glucose tolerance test (ogtt) to be performed during the run-in period in all the subjects * any drug able to influence glucose and lipid metabolism (hypolipidemic drugs, cholesterol lowering foodstuffs, anti-inflammatory drugs) * renal failure (serum creatinine \> 1.5 mg/dl) and liver failure (alt/ast\> 2 times above normal values) * anemia (hb \< 12g/dl) or any other chronic disease

Keywords: wholegrain cereals glycemic index metabolic syndrome insulin sensitivity
prevalence of heterozygote mothers for pompe's disease among mothers having delivered in french guiana

Conditions: Pompe's Disease

Summary: given the high incidence of pompe's disease in french guiana (100 times higher than in mainland france) the aim is to determine the prevalence of heterozygotes among women having just delivered in french guiana who accepted that their newborn child enters the depipomp1 study. in these women the specific mutations p.gly648ser and p.arg854x will be sought using pcr in order to calculate the prevalence of these mutations and estimate the risk factors associated with them in order to improve genetic counselling.


Eligibility criteria:
inclusion criteria: * women having delivered in french guiana whose child was enroled in the depipomp1 study exclusion criteria: * refusal to participate
implementation of a pain management protocol for total knee arthroplasty

Conditions: Knee Replacement, Total

Summary: study question: is there an ideal combination of intraoperative long acting analgesics (periarticular infiltration (pi), femoral nerve block (fb) and intrathecal opioids (io)) to optimize post-operative functional recovery, decrease overall narcotic consumption and enable faster 'readiness to discharge' for patients undergoing primary total knee replacement (tkr)?

our study design is a five-arm double blinded randomized control trial. in order to create a blinded study, each participant will have all three interventions (femoral nerve block (fb), periarticular injection (pi) and intrathecal opioid (io)) performed during their visit. normal saline (ns) will be substituted for opioid or local anesthetic in cases where a control is required. specific 5 arms include: * using all three anesthetics: o pi + fb + io (arm 1) * using a combination of two anesthetics + normal saline substitute for control: * ns + fb + io (arm 2) * pi + ns + io (arm 3) * pi + fb + ns (arm 4) * control: * ns + ns + io (arm 5) the control arm would include io as the sole intervention as this is simply added to the spinal anesthetic used for the surgery itself. it is felt that having a study arm without any long-acting analgesic medication (opioid or local anesthetic) as the "control" arm following a spinal anesthetic would not meet current standard of care and cause harm to the participant the investigators hypothesize that the combination of three forms of long acting analgesia (pi, fb, io) will result in the greatest outcomes compared to a combination of any two or control. our aim is to demonstrate that this optimal analgesic combination will have an additive pain control effect and will minimize side effects thus translating to less acute pain, improve patient mobility, and attaining "readiness to discharge" quicker.

Eligibility criteria:
inclusion criteria: * age 18 years or older * primary total knee replacement for osteoarthritis * agrees to a spinal anesthetic for tkr exclusion criteria: * history of chronic pain or opioid tolerance (individuals requiring equivalent of 1 mg or more intravenous or 3 mg or more oral morphine per hour for greater than 1 month) * general anesthetic for tkr * major neurological deficit * allergy to local anesthetic * allergy to morphine or hydromorphone, anti-inflammatory, acetaminophen * renal insufficiency * liver failure
improving age-related cognitive decline with exercise in hypertensive older adults

Conditions: Hypertension

Summary: the investigator aims to assess the extent to which a brief exercise intervention improves systemic growth factor concentrations, reverses loss of systemic vascular networks and hypertension, and by extension, improves neurocognition. to test the investigator's hypothesis that increased cardiovascular fitness will correlate with improved vascular density, the investigator proposes the innovative use of retinal density scans.


Eligibility criteria:
inclusion criteria: * adults between 55-75 years of age * essential hypertension (as determined by referring physicians) * engages in less than 150 minutes of moderate intensity exercise/week (as determined by champs questionnaire) * physically able to exercise * access to an upright cycle ergometer at home or via gym access * access to smart device (ios or android phone or tablet with ability to install and use polar beat and polar flowtm applications). exclusion criteria: * diagnosis of dementia * resting systolic blood pressure \ 180 mm hg * disease or condition that would preclude exercise * untreated depression or anxiety disorders * severe respiratory disease * disease of the eye * refractive error \> 6 diopters or +6 diopters (as assessed by 1st retinal scan).
recovery of patients from covid-19 after critical illness

Conditions: COVID-19; Critical Illness

Summary: patients who are critically ill with covid-19 requiring life support in an intensive care unit (icu) have increased risk of morbidity and mortality. currently the icu community does not know what effect the disease, the icu admission, physiotherapy interventions and life support have on their long-term quality of life and whether they can return to their pre-illness level of function following icu. covid-recovery will describe the physiotherapy interventions delivered to critically ill patients with covid-19. in survivors, covid-recovery will utilise telephone follow-up of icu survivors to assess disability-free survival and quality of life at 6 months after icu admission. additionally, covid-recovery will identify if there are predictors of disability-free survival. covid-recovery will aim to select up to 300 patients diagnosed with covid-19 from icus in australia. if they survive to hospital discharge, patients will be invited to receive a telephone questionnaire at 6 months after the icu admission that aims to assess their long-term outcomes, including physical, cognitive and emotional function, quality of life, and whether they have been able to return to work following icu discharge. to describe the experience of critical illness in survivors of covid-19 and their family members. to explore and describe functional recovery, respiratory system function and respiratory health morbidity up to 6 months after icu admission in persistently critically ill adults with covid-19


Eligibility criteria:
inclusion criteria: 1. covid-19 patients who have been admitted to icu for \> 24 hours 2. patients aged over 17 years persistent critical illness cohort 1. as above 2. an icu admission of at least 10 consecutive days exclusion criteria: * previous enrolment in this study in a prior icu admission

Keywords: recovery
interdisciplinary mobility approach to reduction of facility-acquired pressure ulcers

Conditions: Pressure Ulcers

Summary: musical reminder will raise compliance with mobility in the long-term care setting and reduce facility-acquired pressure ulcers.


Eligibility criteria:
inclusion criteria: * long-term care resident * mds qualified exclusion criteria: * self pay long-term care residents