Kornimate/medical-research-clean huggingface dataset:
risk factors associated with binge drinking behaviors among college students

Conditions: Binge Drinking

Summary: the purpose of this study is to specify the psychological, cognitive, neuro-functional and genetic profile associated with binge drinker behaviors among young adults. results will help identifying more precisely vulnerability factors associated with this pattern of alcohol consumption and guiding prevention efforts.

binge drinking behavior is characterised by speed of drinking on a particular occasion, frequency of drunkenness during the most recent six month period, and the percentage of times getting drunk when drinking. the prevalence of weekly binge drinking among european union drinkers in 2009 was reported to be 28% of the student population, and 33% among all young people aged 15-24. the consequences of this behavior are multiple and often dramatic, they include: academic failure, violent acts, rape, domestic or road accidents. the study aims to identify vulnerability factors associated with binge drinking. the protocol explores the psychological (personality), neuropsychological (executive functions, memory), genetic (snp polymorphisms) and neuro-anatomical (fmri) patterns associated with binge drinking behavior.

Eligibility criteria:
inclusion criteria : * males or females * right-handed * aged 18-25 years * native french speaker, able to read french and complete study evaluations * caucasian * able to provide informed written and verbal consent exclusion criteria * a significant general medical illness, including neurological disorders, mental retardation or head trauma * depression, bipolar disorder, schizophrenia or schizoaffective disorder diagnostic according to dsm-iv * handling of psychotropics substances * a sensorial impairment (visual and/or hearing) * women who are pregnant * contraindication to the use of mri (pacemaker, metal in their body)
assessing body posture and postural balance among young adults with bronchial asthma

Conditions: Bronchial Asthma

Summary: the purpose of the study is to assess the relationship between body posture and dynamic balance in adults with childhood-onset asthma and compare them to a non-asthmatic control group matched for gender, age, weight, and height.

participants will sign a consent form and provide personal information such as gender, age, weight, and height for calculating bmi, pulmonary function test, and respiratory muscle strength test, as well as their asthmatic/clinical history. after collecting demographic information and obtaining consent from participants, they will be asked to remove their t-shirts and stand in the usual relaxed standing position facing the opposite side of the machine's window. when the machine is properly positioned, it will take photographs. which will then be converted into three-dimensional images on the computer for further analysis. when the participant is fully dressed and ready, the second test will be performed using the biodex balance machine. the parameters and testing mode to begin the dynamic balance test will be entered into the machine, and the procedure will begin. the participants will be thanked for their participation and contribution to our study

Eligibility criteria:
inclusion criteria: * for the healthy subjects referred by a consultant pulmonologist/physician * age- and gender-matched volunteers were recruited from the community exclusion criteria: * other health issues, such as cardiorespiratory issues, neurological deficits * musculoskeletal problems and peripheral vascular diseases\& pregnancy may affect test performance

Keywords: body posture dynamic balance biodex balance system diers formetric 4d posture analysis
music and child health and development

Conditions: Obesity, Infant; Language Development; Parent-Child Relations

Summary: the goal of this clinical trial is to learn about the effects of a music enrichment program on the quality of parent child interactions, a child's motivation to eat, and a child's language environment in 9 to 24 month-old children from low-income families. the main questions it aims to answer are: 1. does participation in a music enrichment program improve the quality of parent-child interactions? 2. does participation in a music enrichment program reduce motivation for food 3. does participation in a music enrichment program improve the quality of the language environment? participants will: 1. be randomly assigned to participate in either 2, 8-week semesters of weekly music enrichment classes or play group sessions. 2. at the beginning, after the first 8 weeks and after the second 8 weeks, a researcher will come to the participants house and parent-child pairs will: 1. be video recorded during 10 minutes of playtime and meal time. 2. fill out questionnaires 3. wear a small wearable language recorder for 16 hours 3. at the beginning, after the first 8 weeks and after the second 8 weeks, the parent and child will come to the baby lab and will: 1. play a computer game to test motivation for food 2. have height and weight measurements collected researchers will compare the music and play groups to see if there is a difference in the quality of parent child interaction, food motivation or language environment.


Eligibility criteria:
inclusion criteria: * family income meets criteria for the national women, infant, and children (wic) program * family is able and willing to commit to a 6-month program exclusion criteria: * mother \<18 years old at the time of delivery * during pregnancy: * mother smoked \>10 cigarettes/day * mother used \>1 marijuana joint/day * mother used any other illicit drugs * mother drank \> 3 standard drinks on a single occasion or \>1 standard drink on a daily basis * preterm birth \<37 weeks gestation * child with significant health issues, and/or genetic conditions (e.g., cerebral palsy, down's syndrome) * mother with major health concerns during pregnancy (e.g., gestational diabetes, pre-eclampsia, etc) * parent/child who do not speak english
nutrition and exercise prehabilitation to reduce morbidity following major liver surgery in sarcopenic patients

Conditions: Liver Cancer; Surgery; Sarcopenia

Summary: nexprem is a single-center non-blinded randomized controlled trial investigating preoperative exercise and nutrition for sarcopenic patients in major hepatic surgery for liver malignancies. patients with sarcopenia undergoing major hepatectomies have high rates of postoperative complications. previous studies have demonstrated that preoperative rehabilitation with exercise and nutrition may help reduce the negative impact of sarcopenia. the investigator's hypothesis is that preoperative nutrition and exercise may reduce complications in sarcopenic patients undergoing major hepatectomies. sarcopenic patients at diagnosis will be randomized in group a undergoing upfront surgery and group b undergoing preoperative rehabilitation. outcome will be overall 90 day morbidity.


Eligibility criteria:
inclusion criteria: * age \>18. * sarcopenic patients diagnosed by both qualitative and quantitative analysis. * patients with primary or secondary liver malignancies. * patients undergoing major liver resections intended as 3 or more contiguous segments * patients undergoing open, laparoscopic, or robotic resections. exclusion criteria: * minor liver resections intended as less than 3 contiguous segments. * patients with intrahepatic, hilar, or extrahepatic cholangiocarcinomas. * patients with liver tumors for whom 6 weeks interval from diagnosis to surgery could not be waited (i.e., large hccs on healthy livers not requiring preoperative portal vein occlusion, crlm without preoperative administration of anti-vegf drug who therefore do not require 6 weeks of chemotherapy washout) * patients with benign liver lesions. * patients undergoing extrahepatic liver resections. * associating liver partition and portal vein ligation for staged hepatectomy (alpps) procedure. * patients with physical disabilities, unable to exercise. * patients with inadequate kidney function.

Keywords: sarcopenia liver cancer liver surgery hepatectomy
fast learning methods

Conditions: Trauma

Summary: training paramedics in new skills via classroom-based teaching has inherent costs and time constraints. the investigators sought to evaluate whether web-based didactics result in similar knowledge improvement and retention of fast (focused assessment with sonography for trauma) compared with the traditional method.

paramedics were randomized into a classroom group with traditional lectures and a web group that watched narrated lectures online. all participants completed a pre- and post-test, and a second post-test four weeks later. both groups underwent hands-on training after the first post-test. a control group completed the two initial tests without didactic intervention.

Eligibility criteria:
inclusion criteria: * give voluntary consent to participate in the study emergency medical professionals (paramedics, nurses, physicians) exclusion criteria: * not meet the above criteria

Keywords: ultrasound
physiotherapy in patients with stable chronic obstructive pulmonary disease

Conditions: COPD

Summary: chronic obstructive pulmonary disease (copd) is a lung disease that is characterized by incompletely reversible airflow obstruction. it is projected to be the fifth leading burden of disease worldwide by the year 2020. pulmonary dysfunction reduces exercise capacity in copd patients, and it has been previously shown that copd patients suffer deterioration in their quality of life. the objective of this study is to examine the effects of a physical therapy intervention in stable patients with copd.

chronic obstructive pulmonary disease (copd) is one of the leading diseases causing mortality and morbidity, despite advanced pharmacotherapy and therapeutic management. although copd primarily affects the lungs, it also implies extrapulmonary manifestations, such as nutritional depletion, skeletal muscle dysfunction, and abnormal respiratory muscles. pulmonary rehabilitation is widely used to treat copd patients and it has been shown that pulmonary rehabilitation should be implemented at all copd stages, bringing them benefits in terms of improved exercise capacity, symptoms, and quality of life.

Eligibility criteria:
inclusion criteria: * copd diagnosis * no contraindication of physiotherapy. * signed written consent. * medical approval for inclusion. exclusion criteria: * acute exacerbation in the previous month * contraindications of physiotherapy. * neurological, orthopedic or heart disease.

Keywords: copd physiotherapy stable disease
effect of baby-cimt in infants younger than 12 months

Conditions: Cerebral Palsy; Hemiplegia; Children

Summary: a randomized control trial investigating if an early intervention program of modified constraint induced movement therapy for babies, baby-cimt, performed before 12 months of age will improve hand function in children with risk for developing cerebral palsy.

the investigators hypothesis is that baby-cimt including intensive specific task oriented training is more preferable than general stimulation which is the assumption for baby massage used in the control group. the intervention protocol is developed at astrid lindgren children hospital, stockholm sweden.

Eligibility criteria:
inclusion criteria:1. a neonatal history of different origin of events affecting the brain, preterm children with predominantly unilateral hemorrhage, venous infarction or with matter lesion or pre, perinatal or early postnatal stroke or infants referred to the hospital/rehabilitation centers/specialists with signs of asymmetries before 8 month of age, likely to be diagnosed with unilateral cerebral palsy at later age. recruitment criteria of child characteristics * age can vary, earliest at 3 months of age and at the latest at 8 months * sign of asymmetries from mild to clear and severe asymmetries, exclusion criteria: severe visual impairment seizures not controlled by drugs not unilateral cp at 12 month

Keywords: infants unilateral cerebral pares hand function early intervention constraint induced movement therapy
cohort of swedish men

Conditions: Cancers; Cardiovascular Diseases; Cataract; Gastrointestinal Diseases; Osteoporosis; Fractures

Summary: the cohort of swedish men began in 1997, when all men born between 1918 and 1952 and residing in two counties in central sweden received a questionnaire including about 350 items concerning diet and other lifestyle factors. a second questionnaire was sent out in 2008-09.

the cohort of swedish men was established in 1997, when all men born between 1918 and 1952 and residing in västmanland and örebro counties in central sweden received a questionnaire concerning diet and other lifestyle factors. of the 100,303 eligible men, 48,850 (49%) responded to the questionnaire. the questionnaire included items about diet, physical activity, medical history, and lifestyle factors such as cigarette smoking history and use of dietary supplements. during 2008-09, the exposure information was updated and extended by sending out two new questionnaires - one questionnaire on health including several signs of symptoms, sleeping, social relations etc (2008) and one on diet, dietary supplement use, and lifestyle factors (2009). majority of questions in the questionnaires have been validated. incident cases of cancer are ascertained by record linkages of the study population with the national swedish cancer register and the regional cancer registers. cardiovascular and other diseases as well as surgeries and causes of death are identified by linkage to the national inpatient and other registries at the swedish board of health and welfare. ascertainment of cancer cases and other diseases is almost 100% complete. dates of deaths are ascertained through the swedish death register (100% complete), and information on date of moving out of the study area is obtained by linkage with the swedish population register.

Eligibility criteria:
inclusion criteria: * all men born between 1918 and 1952, living in central sweden exclusion criteria: * none
a study to evaluate the photoirritation potential of pep005 (ingenol mebutate) gel, 0.01% in healthy volunteers

Conditions: Actinic Keratosis

Summary: this phase 1 study is designed to determine the photoirritation potential of pep005 gel, 0.01% when application is followed by light exposure.


Eligibility criteria:
inclusion criteria: * healthy males or females; * in the case of females of childbearing potential, must be using effective contraception and must provide a negative pregnancy test; * must read, understand and provide signed informed consent. exclusion criteria: * are not willing to refrain from using topical/systemic analgesics within 72 hours prior to and during the study; * are using systemic/locally-acting medications during the study and within 2 weeks prior to the beginning of the study; * are using systemic/locally-acting anti-inflammatories during the study and within 72 hours prior to the beginning of the study; * have participated in any clinical testing of an investigational drug within 28 days or any clinical patch application within 14 days prior to enrollment or are currently participating in any clinical testing.

Keywords: peplin pep005
effect of chlorhexidine gel on bacterial count during fixed orthodontic treatment

Conditions: Orthodontic Appliance Complication; Dental Caries

Summary: this study investigates the benefit of using chlorhexidine gel as an antimicrobial agent in orthodontic patient to reduce caries risk and the possible consequential effect of this use on the orthodontic brackets used for the treatment. the investigators hypothesis is that chlorhexidine gel use can reduce caries risk in orthodontic patients with out causing damage to the bonded ceramic or metal orthodontic brackets.


Eligibility criteria:
inclusion criteria: * patients' age range from 18-30 years. * fixed orthodontic treatment. * all the patients are at the end of leveling and alignment stage. * initial bacterial count indicates high caries risk. * all patients will be given good oral hygiene instruction at the first visit. * the subjects had not taken antibiotics for at least 6 weeks before saliva sampling or during the experimental period. * all subjects used a fluoride dentifrice twice a day. exclusion criteria: * patients' age more or less then the age range specified. * removable orthodontic treatment. * patients at early stages of leveling and alignment. * initial bacterial count indicates low caries risk. * subjects that have taken antibiotics for at least 6 weeks before saliva sampling.

Keywords: chlorhexidine gel orthodontic brackets orthodontic patients bacterial count friction
can doctors reduce covid-19 misinformation and increase vaccine uptake in ghana? a cluster-randomised controlled trial

Conditions: COVID-19

Summary: whilst ghana was one of the first countries to start vaccinating its population against covid-19, less than 30% of the population was fully vaccinated at the end of 2022. to improve covid-19 vaccine uptake, the government has so far relied on two strategies: sensitization in communities and specific national vaccination days. against the backdrop of strict budget constraints and the return to normalcy in health-seeking behaviours, the investigators aim to test the effectiveness of leveraging interactions of patients with the healthcare system to reduce misinformation and increase vaccination. the investigators collaborate with the ghana health service to offer vaccination as a default option during routine consultations. to dispel information and encourage vaccination uptake effectively, the investigators test two interventions designed to encourage and equip front-line providers with skills to discuss covid-19 vaccination with patients. the study evaluates the effect of the two interventions in a cluster-randomised trial where the investigators allocate 120 facilities to one of three groups: a control group where providers are not asked to offer covid-19 vaccines; a light engagement group, where providers receive information about covid-19 and vaccines and a light-touch vaccine monitoring device is deployed in their facility, and a communication skills building group, where providers receive all the elements of the light intervention, plus training in motivational engagement techniques to encourage vaccination. the primary outcome will be vaccination uptake and intentions. the study will also evaluate the impact of the intervention on patients' knowledge, beliefs and satisfaction. the investigators will track the effectiveness of the training on providers as well as the extent to which they apply their training to actual practice. results will contribute to a nascent evidence base on potential ways to encourage adult vaccination during routine consultations.


Eligibility criteria:
inclusion criteria: * mentally sound adults who are aged 16 years and above * presenting at the health centre on the day of surveys exclusion criteria: * received a covid-19 vaccination dose within last 6 months, or received 2 or more doses * have fever, chills, or are experiencing severe pain

Keywords: vaccination hesitancy communication
perioperative blood transfusion in open liver resection

Conditions: Blood Loss, Postoperative

Summary: this observational study is specifically designed to identify the pre-operative risk factors that significantly contribute to perioperative packed red cell transfusions in open liver resection procedures. the main question it aims to answer are: 1. what are the risk factors of peri-operative blood transfusion in open liver resection procedures 2. what are the difference outcomes between patients who receive blood transfusion and the other group. researcher will compare perioperative factor and post operative outcomes between transfused and non-transfused group

after approval of the study protocol from the institutional review board of chiangmai university (approval number: ane-2564-08020), we performed a retrospective review of all patients who underwent an elective open liver resection in our specialized hepato-biliary center from january 2006 through december 2017. this retrospective inquiry comprised 808 patients. the data was systematically retrieved from electronic medical records. baseline characteristics including age, gender, body mass index (bmi), co-morbidity, american society of anesthesiologists (asa) classification, diagnosis, hepatitis profile, child-pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected. the following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, volume and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. the definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the brisbane 2000 terminology

Eligibility criteria:
inclusion criteria: * all genders age above 18 year old who underwent open liver resection from 2006-2017 * elective open liver resection exclusion criteria: * patients who death during the course of a surgical operation

Keywords: liver resection risk factors blood transfusion scoring system
study in healthy adults to evaluate effect of food on pharmacokinetics, safety and tolerability of abt-450 with ritonavir

Conditions: HCV Infection

Summary: the purpose of this study is to evaluate the effect of food on pharmacokinetics, safety and tolerability of an experimental hepatitis c virus (hcv) protease inhibitor with ritonavir in healthy volunteers.

this is an open-label, randomized, 2 cross-over period fasting and non-fasting study.

Eligibility criteria:
inclusion criteria: * overall healthy subjects; * non-childbearing potential females included exclusion criteria: * history of significant sensitivity to any drug; * positive test for hav igm, hbsag, anti-hcv ab or anti-hiv ab; * history of gastrointestinal issues or procedures; * history of seizures, diabetes or cancer (except basal cell carcinoma); * clinically significant cardiovascular, respiratory (except mild asthma), renal, gastrointestinal, hematologic, neurologic, thyroid, or any uncontrolled medical illness or psychiatric disorder; * use of tobacco or nicotine-containing products with the 6-month period prior to study drug administration; * donation or loss of 550 ml or more blood volume or receipt of a transfusion of any blood product within 8 weeks prior to study drug administration; * abnormal screening laboratory results that are considered clinically significant by the investigator; * current enrollment in another clinical study; * previous enrollment in this study; * recent (6-month) history of drug/alcohol abuse that could preclude adherence to the protocol; * pregnant or breastfeeding female; * requirement for any otc and/or prescription medication, vitamins and/or herbal supplements on a regular basis

Keywords: food effect
passive transmission of covid-19 antibody from mother to infant

Conditions: Passive Transmission of Maternal and Infant Antibodies

Summary: at present, there is no relevant research focusing on children's acquisition of novel coronavirus antibodies through maternal passive transmission. therefore, this study assessed the changes of maternal passive transmission of covid-19 antibodies by monitoring the specific antibodies of covid-19 in young children; this will lay a foundation for further exploring the risk of covid-19 infection in children and formulating immune prevention strategies.


Eligibility criteria:
inclusion criteria: 1. children aged 0-2; 2. no history of blood transfusion, chemotherapy, or related immunosuppressive therapy; no immune system related diseases; exclusion criteria: not willing to participate