Kornimate/medical-research-clean huggingface dataset:
treatment trial evaluating long acting insulin in type 1 diabetes

Conditions: Type 1 Diabetes

Summary: patients with type 1 diabetes trained in multiple daily insulin injection were treated with two diffferent kinds of long acting insulin preparations. the two insulin preparations were glargine and ultralente insulin. patients were randomized to receive one of the two insulin preparations for the first 4 months followed by the second preparation for a further four months. short acting insulin used was the same during both periods. we found that glargine insulin was better than ultralente insulin in our study.

multiple daily insulin injection (mdi) programs are commonly accompanied by considerable glycemic variation and hypoglycemia. in order to determine whether use of insulin glargine as a basal insulin would result in comparable hba1c with less glycemic variation and hypoglycemia than ultralente insulin, 22 individuals with type 1 diabetes, experienced with mdi, and a hba1c of \<7.8 % were randomized, to receive either glargine or ultralente as the basal insulin for 4-months. aspart insulin was used as the prandial. physicians providing insulin dose adjustment advice were masked to the type of basal insulin. treatment with glargine resulted in lower mean hba1c, less nocturnal variability , and less hypoglycemia primarily due to less daytime hypoglycemia (p=0.002). on the other hand, serious hypoglycemia and average glucose concentration measured with continuous glucose monitoring system (cgms) did not differ. we conclude that, while use of either ultralente or glargine as a basal insulin can result in excellent glycemic control, treatment with glargine is associated with slightly but significantly lower hba1c, with less nocturnal glycemic variability and less hypoglycemia.

Eligibility criteria:
type 1 diabetes, hba1c \< 7.8%, who have had prior instruction in a complex insulin program, and presently using a mdi insulin program with basal insulin preparations of glargine or ultralente and humalog as the short acting insulin, should be free of hepatorenal abnormalities and hypoglycemia unawareness; non-pregnant, and should be able to perform frequent self monitoring of blood glucose (smbg) and accept the use of continuous glucose monitoring system (cgms). they should also possess the skill and understanding of insulin dose adjustments and supplementation.
weekly paclitaxel, low-dose estramustine, and carboplatin in the treatment of hormone refractory prostate carcinoma

Conditions: Prostate Cancer

Summary: in this trial we will investigate how this three-drug regimen may be improved, both with respect to efficacy and toxicity, by making some modifications in the dosing and schedule in the treatment of patients with hormone refractory prostate cancer.

upon determination of eligibility, patients will receive: paclitaxel + estramustine + carboplatin patients will receive weekly paclitaxel and low-dose estramustine, in combination with carboplatin administered either weekly r every four weeks.

Eligibility criteria:
inclusion criteria: * adenocarcinoma of the prostate not curable with local treatment * disease progression while receiving hormonal therapy * measurable or evaluable disease * previous treatment with a maximum of one prior chemotherapy regimen * ecog performance status 0, 1, or 2. * adequate bone marrow, liver and kidney function * able to comprehend the nature of this study and give written informed consent exclusion criteria: you cannot participate in this study if any of the following apply to you: * age \< 18 years * history of treatment for an invasive malignancy within five years * significant heart disease please note: there are additional inclusion/exclusion criteria. the study center will determine if you meet all of the criteria. if you do not qualify for the trial, study personnel will explain the reasons. if you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
managing obesity by combining behavioral weight loss and commercial approaches

Conditions: Obesity

Summary: the purpose of this study is to examine the effectiveness of 3 behavioral weight loss programs- weight watchers, university-based behavioral weight loss treatment, and a combined approach which includes university-based treatment followed by weight watchers.


Eligibility criteria:
inclusion criteria: * age between 30-65 years * bmi between 27-50 kg/m2 * written approval/consent from primary health care provider exclusion criteria: * unable to walk 2 blocks without stopping. * currently participating in a weight loss program or taking weight loss medication. * participated in a weight loss program in the last year * took weight loss medication in the last 6 months. * participated in weight watchers in last 2 years. * lost \>=5% of body weight during 6 months prior to screening. * pregnant, lactating, less than 6 months postpartum, or plan to become pregnant during study time frame. * report conditions that in the judgment of the principal investigator would render them potentially unlikely to follow protocol for the 12 month study. * report a medical condition that would affect the safety and/or efficacy of a weight management program involving changes in diet and physical activity.
efficacy and safety of quetiapine versus quetiapine plus lithium in bipolar depression

Conditions: Acute Bipolar Depression

Summary: the purpose of this study is to compare the efficacy of quetiapine fumarate monotherapy with quetiapine fumarate in combination with lithium in the treatment of a major depressive episode in patients with bipolar disorder.


Eligibility criteria:
inclusion criteria: * outpatients that meet the diagnostic criteria for bipolar disorder i and bipolar disorder ii with the most recent episode depressed * the total score of the scale that's used for the evaluation of depression (ham-d) should be ≥20 * the total score of the scale that' used for the evaluation of mania (ymrs) should be ≤12 exclusion criteria: * patients with a current dsm-iv-tr axis i disorder other than bipolar disorder within 6 months of enrollment. patients who pose a current serious suicidal or homicidal risk * use of drugs that induce or inhibit the hepatic metabolizing enzymes within 14 days before randomisation * patients who are unable to discontinue all psychoactive medications, including antidepressants, antipsychotics, and mood stabilizers at least 7 days prior to randomisation and consistent with the pharmacokinetics of the drug

Keywords: acute bipolar depression lithium carbonate quetiapine fumarate madrs
the effect of intranasal oxytocin on pain sensitivity and threshold

Conditions: Healthy

Summary: oxytocin is neurohypophysial peptide that acts mainly as a neuromodulator in the brain.the vast majority of basic science studies suggested a large effect of oxytocin in minimizing acute pain.few studies have demonstrated an association between plasma levels of oxytocin and pain in humans. since addictive properties of oxytocin have not been described, the drug may have important application in the management of acute and chronic pain. no studies have examined the effect of intranasal oxytocin on pain sensitivity and threshold.


Eligibility criteria:
inclusion criteria: * healthy males and females volunteers, english speaking exclusion criteria: * pregnancy, lactation, allergy to preservatives, mental disease, any chronic pain and any current use of analgesics, anxiety or depression.

Keywords: volunteers
effects of a mulligan mobilisation in the lumbar flexion range of asymptomatic subjects

Conditions: Low Back Pain

Summary: mulligan's mobilisation techniques are believed to increase the range of movement (rom) in patients with low back pain. the primary aim of this study was to investigate the mechanical effects of mulligan's "snag" technique on lumbar flexion rom. the secondary aim was to measure the intra- and inter-day reliability of lumbar rom employing the same procedure, and utilising a 3-d motion analysis system for measuring range of motion (rom).

the primary aim of this study was to investigate the mechanical effects of mulligan's "snag" technique on lumbar flexion rom. the secondary aim was to measure the intra- and inter-day reliability of lumbar rom employing the same procedure. for the interventional component of the study, 49 asymptomatic volunteers participated in it. subjects were randomly assigned into either a treatment (snag) group (n=25), or a placebo (sham) group (n=24). the "snag" technique was applied on l3 and l4 spinal levels by an experienced manual therapist. snags were performed with active flexion in sitting, 10 times at each level. the placebo-sham was similar to the snag without however applying the appropriate direction or force. lumbar rom was measured by a three dimensional electronic goniometer (zebris cm20), before and after each technique. for the reliability component, five measurements in two different days (one week apart) were performed in 20 healthy subjects.

Eligibility criteria:
inclusion criteria: * asymptomatic * health individuals exclusion criteria: * low back pain * spinal pathology * vascular or heart problems * subjects taking anticoagulants

Keywords: low back pain manual therapy mulligan snag
ngs-based germline and somatic genetic test in ovarian carcinoma

Conditions: Ovarian Carcinoma; Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma

Summary: for patients with ovarian cancer and biologically related diseases, the implementation of genetic testing in the decision-making process could have an impact both on the risk management for the patient and his/her family, but also, more importantly, on the therapeutic management. the identification of genetically predisposed subjects can suggest risk reduction strategies that may involve bilateral salpingo-oophorectomy, mastectomy or long-term medical approaches. in the advanced setting, genetic testing may influence the decision for medical therapy (e.g. use of platinum derivatives or parp inhibitors in patients with "brcaness+" ovarian cancer). the selection of patients for genetic testing has so far been restricted to patients with a strong family history of breast and ovarian cancer. it is now clear that the strict application of this criterion will result in a substantial number of people with a missed brca mutation. systematic large-scale genetic testing, simultaneously on germline and somatic tissues, is likely to improve decision-making algorithms in ovarian cancer patients. the feasibility of such an approach in the clinical setting, in terms of response times compatible with clinical needs and sensitivity comparable if not superior to single-gene tests, needs to be demonstrated before such diagnostic platforms can be routinely implemented in the diagnostic workflow. this is the aim of the present study.


Eligibility criteria:
inclusion criteria: 1. age 18 or higher 2. has signed informed consent 3. histologically confirmed ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. 4. any stage is admitted 5. any histology is admitted 6. availability of surgical/bioptic material. formalin-fixed, paraffinembedded or frozen specimens are both allowed, with no time limitation exclusion criteria: 1. unable or unwilling to receive genetic counseling
induction of stable chimerism for sickle cell anemia

Conditions: Blood Disease; Hematopoietic Stem Cell Transplantation; Anemia, Sickle Cell

Summary: to investigate a modified hematopoeitic cell transplantation (hct) procedure for sickle cell disease that significantly reduces the toxicity of hct, yet retains its therapeutic benefit.

background: hematopoietic cell transplantation (hct) has curative potential for individuals with sickle cell disease. while the results of conventional hct have been good, this treatment carries risks of significant short- term and longterm toxicities. for this reason, hct has been reserved for children who have experienced severe symptoms that predict a poor outcome. of interest, some patients developed stable donor-host hematopoietic chimerism after conventional hct. due to a natural enrichment of donor erythrocytes in the blood, those who developed stable chimerism had a significant clinical benefit, even when there was a minority of donor cells. these observations have paralleled efforts to develop less-toxic, non-myeloablative preparative regiments for transplantation, proved first in a canine model of transplantation, and subsequently translated successfully in a clinical trial for older adults with hematological malignancies. design narrative: multicenter open-label phase i-ii study in 30 children with sickle cell disease that combines a non-myeloablative pre-transplant hematopoietic cell transplantation (hct) therapy with modulated post-grafting immunosuppression to control host-versus-graft and graft-versus-host reactions. the approach relies on the ability to establish and maintain donor-host chimerism. the primary study endpoint is stable donor cell engraftment; secondary endpoints measure the impact of therapy on sickle cell-related symptoms and end-organ damage (disease-free survival, patient survival, graft-versus-host disease, complications etc). the trial will be conducted within the existing network of comprehensive sickle cell centers, and will be centrally coordinated by the sickle cell coordinating center.

Eligibility criteria:
no eligibility criteria
cardiovascular longitudinal alspac research investigations following hypertensive pregnancy in young adulthood

Conditions: Young Adult; Hypertension in Pregnancy; Hypertension; Cardiovascular Diseases; Cerebrovascular Diseases; Vascular Diseases

Summary: the purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease later in life.

women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. the children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. previous work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain that can be measured long before they develop high blood pressure or other clinical symptoms. by understanding the pattern of changes cross multiple parts of the body, over a lifetime, the investigators can identify how advanced the underlying disease is for an individual and how their disease is likely to develop over the next few years. the aim of this study is to understand the heart and blood vessel changes of people born to a hypertensive pregnancy once they are in their 20s and 30s. the investigators then hope to use this information to develop new ways to prevent early onset heart and blood vessel disease in these people.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study * male or female, aged 30 to 40 years at time of enrolment * participant previously took part in the alspac study * able (in the investigator's opinion) and willing to comply with all study requirements * adequate understanding of verbal and written english exclusion criteria: * pregnant or lactating when they are due to attend for study visit 1 * less than six months postpartum * planning to donate blood within two weeks prior to study visit 1 * any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study * evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status for exclusion of mri component only: * unsuitable for mri based on participant screening; the participant may still be included in other parts of the study

Keywords: young adult birth history hypertension in pregnancy cardiovascular risk exercise capacity
postural alignment exercise mobile app for cervical and thoracic spine regions

Conditions: Development and Design of Mobile App; Preventive Physiotherapy; Exercise Adherence; Cervical and Thoracic Spine

Summary: postural alignment in the cervical and thoracic regions is affected by various risks such as smartphone use in particular young adults. the small screen of smartphones causes ergonomic risk for posture and musculoskeletal system. previous studies found that neck, shoulder, and upper back pain associated with the overuse of smartphones. neck pain often arises from unideal postures. participants should be informed about these risks and encouraged to exercise to be protective. digital health apps' use is rising by the day and health apps offer opportunities for both healthcare professionals and users. therefore, this study aimed to develop an app including preventive exercise interventions to keep postural alignment in cervical and thoracic spine regions employing an iterative, user-centred design and to test the usability of the app and evaluate its effectiveness with a pilot randomized controlled trial


Eligibility criteria:
inclusion criteria: * to be a university student aged 18-25, to be a smartphone user for more than 3 years with more than three hours daily use. exclusion criteria: * if they had any chronic health problems (rheumatic, orthopedic, neurological, cardiopulmonary, vestibular system), any trauma in the neck/upper back/upper limb region in the last six months, had a congenital deformity, had received another treatment or having surgery in last one year.

Keywords: mhealth; postural alignment; preventive physiotherapy; exercise adherence; neck pain; upper back pain
the effect of ideal birth environment on birth pain, fear of childbirth, mode of delivery and duration of delivery

Conditions: Pregnant; Fear of Childbirth; Ideal Birth Environment

Summary: the aim of this study was to investigate whether the ideal birth environment is related to fear of childbirth, labor pain, duration of labor, and mode of delivery. on the impact of the study. the main questions it aims to answer are does the ideal birth environment reduce fear of childbirth? does the ideal birth environment reduce labor pain? does the ideal birth environment affect the duration of labor? in order to evaluate the effect of the ideal birth environment on fear, pain and duration of labor, the researchers will compare the standard delivery room and women who will give birth in a room customized for women, where they have their own sheets, pillows, items that make them feel special, where medical devices are reduced, in a room where they have photos with their partner, in a room where they listen to the music they want, where they have freedom of movement. both in the experimental and control groups: in the last trimester, the wijma birth experience a version will be applied and in the postpartum period, the wijma b birth experience scale will be applied again and the fear of childbirth will be evaluated. pain in labor will also be assessed using vas (visceral visual analgesic scale) during the latent and active phase of labor.

the birth environment filled with medical instruments increases the level of anxiety and fear in the mother. increase, disrupting the neurohormonal relationship that ensures the normal functioning of labor and an increase in the rate of cesarean section deliveries. also women when she does not feel safe in her environment and her baby does not feel safe, the birth process is temporary. may slow down as a result release of adrenaline (epinephrine) and noradrenaline (norepinephrine) as a result of stress and anxiety increases, creating a "fight or flight" situation in the woman. adrenaline and noradrenaline are the main towards the end of labor to help the fetus to expel, while towards the end of labor should be at a low level at the beginning. the woman cannot fight stress in these cases, adrenaline and noradrenaline levels increase, while oxytocin levels decrease. this one from a physiological point of view, it can cause the progression of labor to stop, the duration prolonged labor and increased cesarean section rates. in a study conducted with pregnant rats, noise and movement in the birth environment restriction has been found to negatively affect hormones involved in labor

Eligibility criteria:
inclusion criteria: 18-35 years old pregnant primiparous literate exclusion criteria: medium and high-risk pregnant women (oligohydramnios, pre-eclampsia, heart disease, diabetes, placenta previa) * psychiatric illness such as anxiety and depression * communication barrier

Keywords: labor pain ideal birth environment fear of childbirth
sulfonylurea response in patients with diabetes due to kir6.2 mutations

Conditions: Diabetes Mellitus

Summary: the purpose of this study is to investigate whether patients with diabetes due to kir6.2 mutations can be treated with sulfonylurea medication rather than insulin, and if this is the case to investigate the mechanism for sulfonylurea response.


Eligibility criteria:
inclusion criteria: * diabetes due to kcnj11 (kir6.2) mutation exclusion criteria: * none

Keywords: permanent neonatal diabetes kir6.2 kcnj11 infancy onset diabetes sulfonylurea