Kornimate/medical-research-clean huggingface dataset:
energy intake, exercise and constitutional leanness

Conditions: Anorexia Nervosa; Constitutional Leanness

Summary: the aim of this study will be to identify the physical and dietary profile of adult women presenting constitutional leanness (cl), comparatively with normal-weight peers and bmi-matched women with anorexia nervosa. after an evaluation of their daily energy intake, physical activity level, body composition, aerobic capacities and muscle strength, women from the normal weight and cl groups will be asked to realized laboratory sessions to evaluate their energy intake and appetite feelings responses to acute exercise

body composition (using x-ray absorptiometry), muscle strength (biodex), daily energy intake (dietary record), food preferences (leeds food preference questionnaire) and physical activity level (gt3x accelerometers) will be assessed among women with constitutional leanness normal weight women and women with anorexia nervosa. the ct and nw groups will then be asked to randomly realized three experimental session: i) a rest session with an fixed lunch meal; a rest session with an ad libitum meal ; iii) an exercise session with an ad libitum meal. their ad libitum energy intake will be assessed during the two last sessions. appetite feelings will be assessed at regular intervals and their food reward in response to the lunch will also be assessed.

Eligibility criteria:
inclusion criteria: * common criteria to the three groups * women * aged 18 to 35 years old -- signed consent form * being registered in the national social security system * no contraindication to physical activity criteria specific to constitutionally lean women * bmi ≤ 17.5 kg/m2 * weight stable for the last three months * no dietary disorders * no sign of denutrition * absence of amenorrhea criteria specific to women with anorexia nervosa * bmi ≤ 17.5 kg/m2 * pure restrictive anorxia nevrosa: no binge eating or vomiting episodes for the last thress months. * dsm v (2013) crietria criteria specific to normal weight women * 20 kg/m2 ≤ bmi ≤ 25 kg/m2 * weight stable for the last three months * no dietary disorders * no sign of denutrition * absence of amenorrhea exclusion criteria: * pregnancy * intensive physical activity level (aboce 3 sessions per week) * impaired level of igf-1, estradiol, t3free, cortisol and leptin (for normal weight and constitutionally lean women) * previous surgical interventions that is considered as non-compatible with the study. * diabetes * medication that could interfer with the study. * cardiovascular disease or risks * surgery within the last 3 months

Keywords: appetite control leanness physical fitness
functional applications of hyperpolarized 129xe mri

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the overall objectives of our study are to determine the capabilities of hyperpolarized 129xe mri to measure lung function and its potential to sensitively detect pulmonary disease and its progression in copd. we hypothesize that measurement of alveolar surface area, septal thickness, and capillary transit time measured with hyperpolarized 129xe will correlate better with quality of life measures in copd subjects than traditional diagnostic measures such as spirometry and computed tomography.


Eligibility criteria:
inclusion criteria: * age 20-75 for healthy nonsmoker subjects: * no current physician diagnosed medical disease requiring active medication * no smoking history, defined as less than 100 cigarettes smoked in a lifetime * normal spirometry: fev1/fvc ≥ 0.70, fev1 ≥ 80% predicted for subjects who have participated in the copdgene study * post-bronchodilator spirometry: fev1 \> 40% predicted exclusion criteria: * mr contraindications: e.g., electrical implants such as cardiac pacemakers, ferromagnetic implants such as prostheses, claustrophobia * pregnancy or suspected pregnancy * use of continuous oxygen * use of antibiotics and/or systemic corticosteroids (new prescription or increased dose) for an exacerbation of lung disease or any lung infection in the past four weeks * uncontrolled cancer, as defined as ongoing radiation therapy, ongoing chemotherapy * a heart attack in the past three months

Keywords: copd
amprenavir/ritonavir, saquinavir/ritonavir or efavirenz in hiv-infected subjects following failure with kaletra (abt-378/ritonavir) as their first protease inhibitor based haart

Conditions: HIV Infections

Summary: the purpose of this study is to study amprenavir/ritonavir, saquinavir/ritonavir or efavirenz in hiv-infected patients following failure with kaletra (abt-378/ritonavir) as their first protease inhibitor based haart.


Eligibility criteria:
inclusion: * remain on present anti-hiv drugs during screening until a new regimen is started. * have a viral load of at least 1,000 copies/ml on the 2 most recent tests after at least 24 weeks of lopinavir/ritonavir and while still on it. * have an hiv which shows reduced susceptibility to lopinavir. * are at least 18 years old. * are not presently ill. * have not been treated for an opportunistic infection within 30 days of screening. * agree not to take certain drugs and agree to inform and get permission from the doctor before taking any medicines, over the counter medicines, herbal medicines, alcohol or recreational drugs. * agree to use an accepted barrier method of birth control. exclusion: * female subject is pregnant or lactating. * have taken any protease inhibitor other than lopinavir/ritonavir for more that two weeks. * are taking chemotherapy. * have a medical problem with their pancreas. * have been screened for this study within the past 12 weeks. * appear to be unsuitable in the opinion of the doctor.

Keywords: treatment experienced hiv
impact of screening patients with hiv for kidney disease

Conditions: HIV Infections; Renal Insufficiency, Chronic; Proteinuria

Summary: the infectious disease society of america has recently recommended that patients with human immunodeficiency virus (hiv) be screened for kidney disease on a regular basis. screening involves non-invasive urine and blood test and a screening program has already been initiated here in the university of mississippi hiv clinic. this study looks at the effect of this new screening program. our hypothesis is that screening for kidney disease is a cost effective and important addition to the care of patients with hiv.

the infectious disease society of america has recently recommended that patients with human immunodeficiency virus (hiv) be screened for kidney disease on a regular basis. screening involves non-invasive urine and blood test and a screening program has already been initiated here in the university of mississippi hiv clinic. however nobody knows for sure whether this will help doctors take better care of patient with hiv. this study looks at the effect of this new screening program. we want to see how frequently abnormalities are seen on screening, how frequently certain kidney diseases are diagnosed, how often patients are referred to a nephrologist and how often a patient's management is changed by the screening. we will also estimate the cost-benefit ratio of the screening. we will review patient charts to determine what has happened in each case where screening was conducted. this study will not involve any additional testing. the benefit of this study will be improving our understanding of kidney disease in hiv. it will help us determine the value of screening for kidney disease and the frequency of certain kidney diseases in hiv in our clinic population.

Eligibility criteria:
inclusion criteria: * adult patients with hiv who are seen by the university of mississippi infectious disease clinic at the jackson medical mall or patient seen at the university of mississippi nephrology clinic.

Keywords: hiv
retinal nerve fiber layer thickness changes in migraine: a meta-analysis of case-control studies

Conditions: Migraine

Summary: optical coherence tomography (oct) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (rnfl) and measure its thickness. a reduction of the rnfl thickness has been detected in several neurodegenerative diseases, such as multiple sclerosis, cadasil and alzheimer's disease. different studies have reported rnfl changes also in migraine, is a common hereditary chronic neurovascular disorder, characterized by dysfunction of the autonomic nervous system. the pathophysiology of migraine has not been fully clarified, but there is increasing evidence that episodes of migraine with aura are initiated by a focal reduction in cerebral blood flow, which occurs most commonly in the posterior region of one hemisphere. although vasoconstriction of cerebral and retinal blood vessels is a transient phenomenon, the chronic nature of the migraine might cause permanent structural abnormalities of the brain and also of the retina, which may correlate with rnfl thinning. previous studies on this subject, however, reported contradicting results. some investigations reported reductions of the rnfl thickness while others did not. in the present study, in order to determine whether rnfl thickness is reduced in migraine patients, the investigators performed a meta-analysis and systematically evaluated rnfl thickness measurements with oct in a series of migraine patients and in the healthy control groups.


Eligibility criteria:
inclusion criteria: 1. case-control studies; 2. patients with migraine were compared with healthy controls; 3. all subjects underwent rnfl thickness measurement by oct; 4. studies should provide the data of peripapillary rnfl thickness; 5. sample size ≥10 in each group. exclusion criteria: 1. authors did not make rnfl measurements; 2. study without healthy control group; 3. the outcome values can not be used for meta-analysis; 4. duplicated articles.

Keywords: retinal nerve fiber layer thickness optical coherence tomography migraine
evaluation of an adaptive computerized training for rehabilitation of spatial neglect in stroke survivors

Conditions: Stroke; Spatial Neglect; Neglect, Hemispatial; Attention Impaired; Cerebrovascular Disorders

Summary: the aim of this study is to investigate the effect of training with an adaptive computer game, in comparison to standard training, in the rehabilitation of stroke survivors suffering from spatial neglect.

many stroke survivors who have suffered right brain damage show spatial neglect (sn), a deficit of spatial attention orienting that causes unawareness for stimuli located in the left hemispace. recent data show that the execution of concurrent tasks (that is, multitasking) can worsen the clinical condition and impact functional recovery. the aim of this study is to investigate the effect of an adaptive computer game "labyrinth" previously validated on health population. the videogame is designed for training both attention and execution functions as it engages spatial navigation and multitasking. the effect of the computer game will be compared to standard computerized exercises used for neglect rehabilitation. the investigators plan to administer to a sample of 30 stroke patients with sn both labyrinth and standard trainings for 10 sessions each. the two trainings will be delivered in a randomized crossover design. improvements of patients' performance will be registered across trainings and in a follow-up test at 1 month, by assessing the severity of sn and functional everyday outcomes. the investigators expect that patients' performance will improve following both types of training, but with stronger improvement for the adaptive videogame.

Eligibility criteria:
inclusion criteria: * first stroke patients with right brain damage * right-handed * preserved italian language comprehension to provide informed consensus * clinical signs of spatial neglect (diagnosis by bit) exclusion criteria: * prior history of psychiatric or neurological disease * substance abuse * inability to sustain the experimental trainings

Keywords: neglect recovery of function rehabilitation videogame post-stroke
em-power: maximizing functional independence for children with severe cerebral palsy

Conditions: Cerebral Palsy

Summary: for children with severe cerebral palsy, a powered wheelchair (pwc) may provide their only option for functional mobility and independence. pwc use is often restricted to a small percentage of children who can quickly demonstrate proficient pwc skills within a single 30-minute pwc trial. this 2-arm, parallel group, single blinded, pre-test-post-test randomized controlled trial will test our hypothesis that an 8-week pwc skills training intervention will produce greater improvements in children's pwc skills capacity immediately after the intervention and at an 8-week follow-up assessment.


Eligibility criteria:
inclusion criteria: * diagnosis of severe cp (gross motor function classification system level iv or v) * inability to functionally walk or functionally propel a manual wheelchair as assessed by the principal investigator a licensed physical therapist * demonstrate cause and effect skills in the indietrainer consistent with an assessment of learning powered mobility use (alp assessment) phase 4 or higher (i.e., understand that they are moving the indietrainer using the switch(es) or joystick) as assessed by the principal investigator, a licensed physical therapist. * in addition, one parent/caregiver must be conversant in english and be able to provide their child's medical and health history and be willing to take on the parent participant role. exclusion criteria: * the inability to sit in their own manual wheelchair or adaptive stroller for 60 minutes (as this would preclude them safely using the indietrainer system for the 60-minute intervention sessions) * their manual wheelchair or adaptive stroller cannot be safely used with the indietrainer system * they already have an individually prescribed power wheelchair * if the principal investigator, a licensed physical therapist, determines that based on the child's medical and health history, that they cannot safely participate in power wheelchair skills training.
study to evaluate the combination of enteric-coated mycophenolate sodium (ec-mps), basiliximab, and c2-monitored cyclosporine in de novo renal transplant recipients at potential high risk of delayed graft function (dgf)

Conditions: Renal Transplantation

Summary: the aim of the study is to assess the short-term benefit of the combination of basiliximab, ec-mps and cyclosporine microemulsion with c2 monitoring on the prophylaxis of acute rejection in a population of de novo renal transplant patients at potential high risk of dgf.


Eligibility criteria:
inclusion criteria: - age 18-70 years old * patients receiving a primary or secondary cadaveric or living donor kidney * patients who have given written informed consent for study participation * females capable of becoming pregnant must have a negative pregnancy test at baseline and are required to practice birth control for the duration of the study and at least for four months following the last dose of basiliximab. exclusion criteria: * recipient of multi-organ transplants or previously transplanted organs other than kidney * recipient of dual kidney transplants * recipient of a transplanted kidney from a non-heart beating donor (nhbd) * recipient of a hla identical living-donor kidney * patients with a pra level (past or current level) greater than 20% * patients anticipated by investigators to require induction therapy with okt3, atgam, or thymoglobulin for any reason * patients with any medical condition which, in the opinion of the investigator, would preclude the patient from participating in the study * cold ischemia time larger than 36 hours. * patients who have received an investigational drug or therapy within one month prior to study entry or if such therapy is to be instituted post-transplantation. * female transplant candidates who are pregnant, lactating, or of childbearing potential and not willing to practice an acceptable method of contraception * patients with a known hypersensitivity to cyclosporine * patients with a known malignancy or a history of malignancy, other than successfully treated non-metastatic basal or squamous cell carcinoma of the skin * known hiv positive antibody status * evidence of any clinically relevant (per investigator determination) active infection * patients unable to participate in the study for the full 3-month study period * other protocol-defined exclusion criteria may apply.

Keywords: renal transplantation, dgf, basiliximab, ec-mps, cyclosporine
study to evaluate the pharmacokinetics, safety, and tolerability of dimebon [pf-01913539] in subjects with hepatic impairment and normal hepatic function

Conditions: Hepatic Failure

Summary: 1. to compare the pharmacokinetics of dimebon in subjects with mild and moderate hepatic impairment to subjects with normal hepatic function. 2. to assess the safety and tolerability of dimebon in subjects with hepatic impairment and subjects with normal hepatic function. 3. to explore the pharmacokinetics of dimebon in subjects with severely-impaired hepatic function.


Eligibility criteria:
inclusion criteria: * healthy (healthy is defined as the absence of clinically-relevant abnormalities identified by a detailed medical history, full physical examination, 12-lead ecg and clinical laboratory tests). * free of any medical or surgical conditions that might significantly interfere with gastrointestinal absorption, distribution, metabolism, or excretion of dimebon. * demographically comparable to subjects with mild and moderate hepatic impairment. * subjects with hepatic impairment: screening medical history, physical examination, vital signs, 12-lead ecg, and clinical laboratory tests performed within 28 days before the first dose of study medication, abnormal findings that are related to the subject's underlying condition are acceptable. * satisfy the criteria for class a, b, or c of the modified child-pugh classification \[mild (child-pugh scores 5-6 points), moderate (child-pugh scores 7-9 points), and severe (child-pugh scores \>9 and \<12 points)\] within 14 days before the first dose of study medication. * a diagnosis of hepatic impairment due to cirrhosis, not secondary to other diseases, which is confirmed and documented by medical history, physical examination, liver biopsy or hepatic ultrasound, ct scan or mri. exclusion criteria: * subjects presenting with any of the following will not be included in the trial:cyp2d6 pm genotype, as identified by screening genotyping. * a known sensitivity to dimebon. * exposure within the previous three months to a drug known to have a negative effect on skeletal muscle or reproductive organs. * history of febrile illness within 5 days prior to the first dose. * any condition possibly affecting drug absorption (e.g., gastrectomy, active peptic ulcer within last 3 months).

Keywords: dimebon hepatic impairment
infrared-led during physical training for rehabilitation, physical performance and body aesthetics

Conditions: Healthy

Summary: the investigators hypothesis is that the infrared-led illumination during treadmill training can enhance physical performance in postmenopausal women. the basis for such a hypothesis is based on the fact that the light therapy during the intense metabolic stage caused by exercise may be more efficient.

phototherapy improves cellular activation via absorption of photons by chromophores present in the protein components of the mitochondrial respiratory chain - mainly nadh dehydrogenases and cytochrome c oxidase, which leads to increased electron transport, production of atp, and tissue regeneration (skin, muscle, bone, and nerves). moreover, phototherapy stimulates the anti-inflammatory effect with analgesia and vasodilatation. regarding body aesthetics, phototherapy increases microcirculation, lymphatic drainage, as well as collagen synthesis for the treatment of cellulite. the objective of this study was to develop and evaluate the effects of a new clinical procedure: infrared radiation originated from leds associated with treadmill training in postmenopausal women. led arrays were developed for an irradiation of a large area, such as hip and quadriceps muscles, main actuators during stance and swing phases. these body parts are furthermore areas where there is incidence of osteoporosis, mainly at the femur, localized fat deposits, and cellulite. infrared radiation (850 nm) was selected because this spectral range shows better skin penetration compared to red interval.

Eligibility criteria:
inclusion criteria: * postmenopausal women * caucasian * 50 and 60 years of age * healthy exclusion criteria: * neurological disease * inflammatory disease * pulmonary disease * oncological disease * cardiac disease * endocrinopathy * musculotendinous or articular injuries * hormone replacement therapy or osteoporosis drugs * cigarette smoking

Keywords: infrared led treadmill training strength muscle fatigue muscle aerobic capacity cellulite osteoporosis
malaria prevention cambodia

Conditions: Malaria

Summary: trial of monthly dha-piperaquine for malaria prevention in health volunteers.

this is a two arm, randomized, double-blind, placebo controlled cohort study to determine the protective efficacy of a monthly 2 day treatment course of dihydroartemisinin-piperaquine (dp) in adult volunteers in malaria endemic areas of cambodia.

Eligibility criteria:
inclusion criteria: 1. volunteer 18-65 years of age 2. able to give informed consent 3. likely to reside in malaria endemic area for the duration of the study 4. available for follow-up for anticipated study duration, and agrees to participate for the duration of the study 5. agrees not to seek outside medical care for febrile illness, except in emergency situations, unless referred by study team 6. authorized by local commander to participate in the study if on active duty exclusion criteria: 1. known allergy or other contraindication to dha, piperaquine treatment, and/or primaquine treatment 2. significant acute comorbidity requiring urgent medical intervention 3. positive malaria blood smear. 4. treatment with an antimalarial drug in the past 30 days. 5. pregnant or lactating female or a female of childbearing age who does not agree to use a highly effective method of birth control during the study 6. significantly abnormal ekg including a qtcf interval greater than 450ms at baseline (or 470ms for females) using fridericia's correction 7. regular current use of known qtc prolonging medications 8. history of sudden cardiac death in an immediate family member, or personal history of known symptomatic coronary artery disease or arrhythmias 9. judged by the investigator to be otherwise unsuitable for study participation or non-compliant with study requirements

Keywords: plasmodium falciparum plasmodium vivax