Kornimate/medical-research-clean huggingface dataset:
subharmonic imaging and pressure estimation for monitoring neoadjuvant chemotherapy

Conditions: Breast Cancer

Summary: this is a diagnostic accuracy study to evaluate if two novel ultrasound (us) techniques, quantitative 3d subharmonic imaging (shi) and subharmonic aided pressure estimation (shape), used with an intravenous ultrasound contrast agent (definity, lantheus medical imaging, billerica, ma), can track changes in locally advanced breast cancer (labc) angiogenesis and interstitial fluid pressure (ifp), respectively, by studying women undergoing neoadjuvant chemotherapy before as well as with around 10% and 60% (in part 1) or 30% (in part 2) of the neoadjuvant chemotherapy treatment delivered and after completion of the neoadjuvant chemotherapy treatment. results will be compared to mri and pathology.


Eligibility criteria:
inclusion criteria: * females * be diagnosed with t1 or greater labc, any n and m0. * be scheduled for neoadjuvant chemotherapy * be at least 21 years of age. * be medically stable. * if a female of child-bearing potential, must have a negative pregnancy test. * have signed informed consent to participate in the study. exclusion criteria: * males * females who are pregnant or nursing. * patients with other primary cancers requiring systemic treatment. * patients with any metastatic disease. * patients undergoing neoadjuvant endocrine therapy. * patients with known hypersensitivity or allergy to any component of definity. * patients with cardiac shunts or congenital heart defects. * patients with unstable cardiopulmonary conditions or respiratory distress syndrome. * patients with uncontrollable emphysema, pulmonary vasculitis, pulmonary hypertension or a history of pulmonary emboli. * patients who have received any contrast medium (x-ray, mri, ct or us) in the 24 hours prior to the research us exam.

Keywords: breast cancer interstitial fluid pressure angiogenesis contrast enhanced ultrasound imaging subharmonic imaging subharmonic pressure estimation
non-invasive cooling of subcutaneous fat

Conditions: Fat Disorder

Summary: the purpose of this study is to evaluate a non-invasive cooling device to determine if cold exposure will consistently result in a reduction of subcutaneous fat.

the purpose of this study is to evaluate a non-invasive cooling device to determine if cold exposure will consistently result in a reduction of subcutaneous fat using the zeltiq dermal cooling device.

Eligibility criteria:
inclusion criteria: 1. male or female subjects \> 18 years of age. 2. subject has clearly visible fat on the flanks, thighs, abdomen, or back. 3. subject has not had weight change fluctuations exceeding 10 pounds in the preceding month. 4. subject has read and signed a written informed consent form. exclusion criteria: 1. subject has had liposuction, or another surgical procedure(s) or mesotherapy in area of intended treatment within the past 2 years. 2. subject has a known history of subcutaneous injections into the area of intended treatment (e.g., cortisone) within the past 6 months. 3. subject has a known history of cryoglobulinemia, cold urticaria, or paroxysmal cold hemoglobinuria. 4. subject is taking diet pills within the past 6 months. 5. subject is unable or unwilling to comply with the study requirements. 6. subject has any dermatological conditions or scars within the location of the test sites that may interfere with the treatment or evaluation. 7. subject is currently enrolled in a clinical study of any other unapproved investigational drug or device. 8. patient is pregnant or intending to become pregnant in the next 9 months. 9. patient is lactating or has been lactating in the past 9 months. 10. any other condition or laboratory value that would, in the professional opinion of the investigator, potentially affect response or participation in this clinical study, or would pose an unacceptable risk to the subject.
effects of scapulathoracic stabilization exercises plus complex decongestive therapy in women with lymphedema

Conditions: Lymphedema; Exercise

Summary: the aim of the study is to investigate the effects of scapulathoracic stabilization exercises additionally applied to complex decongestive therapy after mastectomy on posture, balance and quality of life.

lymphedema is a chronic and progressive condition that occurs with the accumulation of protein-rich fluid in interstitial tissue spaces as a result of abnormal development or damage to the lymphatic system. lymphedema is divided into 2 as primary and secondary. secondary lymphedema is the most common form seen in upper extremity, usually after breast cancer treatment approaches. in lymphedema, not only upper limb affected, but also posture, balance, shoulder girdle, scapula and quality of life can be adversely affected. complex decongestive therapy has been accepted as the gold standard treatment in lymphedema to reduce edema, however, there were insufficient studies investigating the effects on the posture and the balance in patients with lymphedema. scapulatoracic stabilization exercises aim to increase muscle stability ability, kinesthetic awareness, ovarall stability and balance. however, when the literature is reviewed, no study is found investigating the effect of scapulatoracic stabilization exercises in individuals who developed lymphedema after mastectomy.

Eligibility criteria:
inclusion criteria: * 18 to 65 years of age * agree to participate in the study, * undergoing unilateral mastectomy due to breast cancer treatment and additionally development of limb lymphedema, * lymphedema stage 2 and 3, * being a woman, * having spent at least 6 months after the operation * with or without radiotherapy and / or chemotherapy. exclusion criteria: * irregular participation to the treatment program, * severe heart failure and / or rhythm disturbance, * uncontrolled hypertension, * presence of metastasis, * infection in the affected arm, * any problems that may affect balance (rheumatological, vestibular, visual, neurological), * muscular and skeletal system problems (limb shortness, ankle sprain ...), which may affect the balance and posture negatively. * presence of spinal deformity, * those who have had spinal surgery in the last 6 months.

Keywords: lymphedema decongestive therapy exercise posture balance
a phase i/ii study of astx660 in patients with relapsed or refractory t-cell lymphoma

Conditions: Relapsed or Refractory Peripheral T-cell Lymphoma(PTCL),Cutaneous T-cell Lymphoma(CTCL),Adult T-cell Leukemia/Lymphoma(ATLL)

Summary: phase 1 (dose-escalation part): investigate the tolerability and safety of astx660 in patients with r/r ptcl and r/r ctcl and determine the recommended dose (rd) for the phase 2. phase 1 (atll expansion part): evaluate the safety of astx660 at rd in patients with r/r atll. phase 2 : evaluate the efficacy of astx660 at rd in patients with r/r ptcl.


Eligibility criteria:
inclusion criteria: 1. patients with t-cell lymphoma with histological diagnosis based on who classification (2017) 2. patients with evaluable lesions. 3. patients with ecog ps score of 0 or 1. 4. patients with adequate organ functions as shown below. * ast and alt ≤ 2.0 × uln (≤ 3.0 × uln if liver infiltration is present) * total bilirubin ≤ 1.5 × uln * anc ≥ 1,000/mm3 (≥ 750/mm3 if bone marrow infiltration is present) * platelet count 50,000/mm3 (25,000/mm3 if bone marrow infiltration is present) * serum creatinine ≤ 1.5 × uln or creatinine clearance ≥ 50 ml/min * amylase and lipase ≤ 1.0 × uln exclusion criteria: 1. patients with active infection requiring treatment with antibiotics, antifungals, or antivirals 2. patients with heart disease that meets the followings: 1. lvef of \< 50% by echocardiography or muga scan 2. congestive heart failure (nyha classification iii or iv) 3. uncontrolled heart disease including unstable angina pectoris or hypertension considered to require hospitalization within last 3 months (90 days) 4. complete left bundle branch block, iii degree (complete) atrioventricular block, use of pacemaker, history or complication of poorly controlled arrhythmia requiring treatment 5. history or complication of long qt syndrome 6. history or complication of ventricular arrhythmia requiring active treatment 7. corrected qt interval of ≥ 470 msec based on 12-lead ecg performed at the screening 8. concern on increased cardiac risk by participating in the study based on medical judgment 3. patients receiving the following treatment for the primary disease prior to the initial dose of study drug 1. chemotherapy or radiotherapy within last 3 weeks 2. skin directed therapy including local treatment or phototherapy within last 3 weeks 3. treatment with monoclonal antibody within last 4 weeks 4. treatment with other study drugs or study treatment within last 3 weeks or 5 half-lives, whichever is longer 4. patients with prior allogeneic stem cell transplantation, or autologous stem cell transplantation within 14 weeks prior to the day of initial dose of study drug 5. patients who have received corticosteroids at a dose exceeding a prednisone equivalent dose of 10 mg/day within 3 weeks prior to the initial dose of study drug. 6. patients with inadequately controlled diabetes mellitus
compensatory cognitive training in clinical high risk latino youth

Conditions: Clinical High Risk; Psychosis; Prodromal; Schizophrenia

Summary: this is a randomized study to compare compensatory cognitive training (cct) versus recreational therapy (rt) in latino clinical high risk individuals in the us and mexico. study hypotheses: compared to those who receive rt, study participants receiving cct will show significant improvement in neurocognition, functional capacity, self-rated functioning and clinical measures.

this is a 12 week randomized study to compare compensatory cognitive training (cct) versus recreational therapy (rt) in latino clinical high risk individuals in the us and mexico. study participants will be measured 3 times, at baseline, 12 and 24 weeks on all outcome measures. study hypothesis: study participants receiving cct will show significant improvement at 12 and 24 weeks compared to baseline in 1) neurocognition using the global cognitive index z score derived from the matrics neurocognitive domain scores, 2) functional capacity as assessed by the ucsd performance-based skills assessment (upsa/upsa-adolescent), 3) self-rated functioning as measured by the specific level of functioning scale (slof) and 4) clinical symptom ratings as measured by the scale of prodromal symptoms (sops) total score when compared to subjects receiving rt training across study time.

Eligibility criteria:
inclusion criteria: * meet clinical high risk criteria * be of latino descent * speak spanish as their preferred language exclusion criteria: * concomitant medical or neurological illness * brain injury with loss of consciousness \> 30 minutes * current substance abuse (excluding nicotine) * iq \< 80 * high suicidal risk

Keywords: psychotic disorders cognitive training mental disorders schizophrenia and disorders with psychotic features
comparison of primovist-enhanced mri, diffusion weighted mri and multidetector ct of colorectal liver metastases

Conditions: Colorectal Liver Metastases

Summary: 1. primovist-enhanced magnetic resonance imaging (mri) and diffusion weighted mri (dw-mri) is superior to multidetector computed axial tomography (mdct) in the detection of colorectal liver metastases. fatty changes in the liver after chemotherapy treatment likely reduces the chances of seeing metastatic lesions on ct especially when the lesions are small (\<10 mm). when compared with ct, primovist-enhanced mri and dw-mri have the potential to provide higher contrast resolution enabling better detection of colorectal liver metastases following chemotherapy. 2. primovist-enhanced mri and dw-mri are superior to ct in assessing and predicting treatment response of patients with colorectal liver metastases to chemotherapy. primovist-enhanced mri by providing superior resolution may provide improved accuracy in metastatic lesion margin detection thereby providing higher accuracy in estimating tumor response based on size criteria. dw-mri provides information indirectly about tumor composition and therefore is likely to be superior to md-ct in assessing treatment response. two groups of patients will be analyzed. the second group consists of patients with colorectal liver metastases who are to go for chemotherapy prior to surgery for metastases resection. this group will be ct and mri scanned prior to chemotherapy and after chemotherapy. the first group of patients will consist of those patients who have already received chemotherapy and are likely to have surgery to resect liver metastases. this group will have only one set of scans done 4-6 weeks prior to their operation. the pathology of the resected metastases and ct and mri images will be analyzed and compared.


Eligibility criteria:
inclusion criteria: * patients with colorectal liver metastases already treated by chemotherapy and scheduled for surgical resection * patients with colorectal liver metastases scheduled to receive chemotherapy with possibility of future liver resection. exclusion criteria: * acute or chronic renal disease with estimated gfr (egfr) \<30 ml/min. * hypersensitivity to mri contrast or ct contrast or to any ingredient in the formulation or component of the container. * patients with: acute or chronic severe renal impairment (glomerular filtration rate \<30 ml/min/1.73 m2), or acute renal insufficiency of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period. * general contraindications to mri such as pacemaker or ferromagnetic implants. * severe cardiovascular problems * pregnant or nursing women * age \<18 years * liver surgery is not a possibility.

Keywords: colorectal liver metastases primovist mri ct cancer resection mdct diffusion weighted 3t
dementia-friendly community training using virtual reality among college nursing students

Conditions: Dementia

Summary: this study aims to evaluate the effectiveness of a dementia course using virtual reality, world café teaching method and community practice on knowledge of dementia and dementia-friendly community, attitude toward dementia, and empathy toward people with dementia among nursing college students.

this two-group randomised controlled trial aims to evaluate the effectiveness of a dementia course using virtual reality on knowledge of dementia and dementia-friendly community, attitude toward dementia, and empathy toward people with dementia among nursing college students. the interventional group will receive the dementia course consists of dementia virtual reality activity, intergenerational learning, world café teaching method and community practice. the control group will only receive the dementia course with intergenerational learning, world café teaching method and community practice but no dementia virtual reality activity. both groups will be assessed for their dementia knowledge, attitudes, empathy and knowledge of dementia-friendly community at baseline, week 8, and week 18.

Eligibility criteria:
inclusion criteria: * college nursing students with age ranged from 19 to 40 years, * taiwanese nationality, * sophomore and above * provide informed consent to participate in the study. exclusion criteria: college nursing students who do not meet the inclusion criteria
2-day prophylactic antibiotic is effective in transoral endoscopic thyroidectomy

Conditions: Thyroid Nodule

Summary: in transoral thyroidectomy via vestibular approach (toetva), prophylactic antibiotic for 5\~7 days is recommended for the clean-contaminated wound. in this study, the investigators design a 2-day versus 7-day antibiotic prophylaxis to compare the surgical result and infection rate.

remote-access thyroid surgery has gained popularity and has advanced significantly over the past two decades, given the patient desire to avoid cosmetically displeasing scarring. the mostly recently introduced remote thyroid surgery is the transoral endoscopic thyroid surgery via vestibular approach (toetva). because of the several advantages comparing with other removeaccess thyroid surgery, making it nowadays growing in popularity since 2016. however, toetva carry some inherent risks, including mental nerve injury, tumor seeding and local recurrence, fibrosis-induced long-lasting pulling sensation below the lower jaws, and surgical site infection coming from the clean-contaminated environment of oral incision. comparing with clean wound via the traditional open surgery, toetva carry the potential risk of infection. based on the author's recommendation, prophylactic antibiotic (augmentin) will be administered 30 minutes before incision at operative room, followed by 2-day course of intravenous antibiotic, then shift to 5-day course of oral antibiotic finally. up to date, only few case complicating postoperative infection were reported with extremely low infection rate (\<1%). therefore, the investigators want to study the short-course (2 days) of antibiotic coverage is also effective to prevent surgical site infection. it was proved in the preliminary study, comprising 5 patients in each group (2-day course in the study group and 7-day course in the control group). later, the investigators will recruit more patients (n=100) to confirm this study.

Eligibility criteria:
inclusion criteria: 1. suspicious or proved thyroid cancer with size smaller than 4cm 2. symptomatic benign thyroid nodules less than 6cm in size 3. thyroid cyst 4. follicular neoplasm 5. graves' disease exclusion criteria: 1. previous thyroid or parathyroid surgery 2. history of radiation at neck 3. could not tolerate the general anesthesia.

Keywords: transoral surgery
study to evaluate the efficacy, safety, and tolerability of oral opc-34712 and aripiprazole for treatment of acute schizophrenia

Conditions: Schizophrenia

Summary: this will be a multicenter, randomized, double-blind, placebo-controlled study designed to assess the tolerability, safety, and efficacy of opc-34712 (0.25 to 6.0 mg) for the treatment of adult subjects hospitalized with an acute relapse of schizophrenia. aripiprazole (10 to 20 mg) is included as a positive control to confirm the assay sensitivity of the study. a total of approximately 563 subjects will be screened at an estimated 75 sites worldwide in order to obtain approximately 450 randomized subjects.


Eligibility criteria:
inclusion criteria: 1. male or female subjects between 18 and 65 years of age, with a diagnosis of schizophrenia, as defined by dsm-iv-tr criteria 2. subjects who have been recently hospitalized or who would benefit from hospitalization for an acute relapse of schizophrenia 3. subjects experiencing an acute exacerbation of psychotic symptoms exclusion criteria: 1. females who are breast-feeding and/or who have a positive pregnancy test result prior to receiving study drug 2. subjects with a current dsm-iv-tr axis i diagnosis of: * schizoaffective disorder * mdd * bipolar disorder * delirium, dementia, amnestic or other cognitive disorder * borderline, paranoid, histrionic, schizotypal, schizoid or antisocial personality disorder 3. subjects presenting with a first episode of schizophrenia 4. other protocol specific inclusion/exclusion criteria may apply

Keywords: schizophrenia relapsed
taiwanese people's willingness to participate in cancer screening: colon, oral cavity, breast, and cervical cancer screening

Conditions: Healthy

Summary: cancer screening is necessary for promoting cancer prevention in the area of public health. the department of health, executive yuan of the republic of china has expanded and included colon cancer screening, oral cavity cancer screening, breast cancer screening, and cervical cancer screening in national-wide preventive healthcare services. however, most of the taiwanese do not have the concepts of what cancer screening is and regular participation of cancer screening. this will easily cause their neglect of quality of personal healthcare and habits of cancer screening. recently, in order to reach the national goal of cancer prevention, the parallel methods, multi-promotion for reinforcing concepts and free cancer screening, have been utilized to cultivate taiwanese people's active participation of cancer screening. therefore, this study will use health service utilization model to investigate taiwanese people's concepts of cancer-related knowledge and the major causes of low participation of cancer screening. in order to investigate taiwanese people's health service utilization model and quality of health life, this study first review the related regulations and screening rates of cancer prevention, including cancers of colon, oral cavity, breast, and cervical, in taiwan. in addition, the structured questionnaire will be conducted to collect, investigate, and analyze the relationship between the willingness of participating the aforementioned cancer screening and personal characteristics, quality of health life, medical history, and concepts of cancer, etc. it is expected that the results of this study will provide accurate and effective promotions of cancer screening to medical institutions and medical affairs to reinforce the concepts of participation for raising the rates of cancer screening; furthermore, to awaken taiwanese people's crucial awareness of early treatment improves the chances of recovery on cancer.


Eligibility criteria:
inclusion criteria: cases who are willing to answer the questionnaire exclusion criteria: cases who are not willing to answer the questionnaire

Keywords: cancer screening health service utilization model quality of health life
multifunctional nutrition tube on social condition and experience in cerebralvascular accident

Conditions: Stroke

Summary: the aim of this clinical trial is to compare the psychological condition and experience of ischemic stroke patients who receive enteral nutrition support through either intermittent oro-esophageal tube or nasogastric tube. patients will be randomly assigned to either an observation group or a control group, with both groups receiving routine rehabilitation treatment. the observation group will receive enteral nutrition support through intermittent oro-esophageal tube, while the control group will receive it through nasogastric tube. researchers will then compare the social condition and experience of the two groups.

the study will last 15 days for each participant. the goal of this clinical trial is to compare the differences on psychological condition and experience in ischemic stroke patients using intermittent oro-esophageal tube and nasogastric tube. patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. on this basis, the observation group will use intermittent oro esophageal tube for enteral nutrition support, while the control group will use nasogastric tube. researchers will compare social condition and experience of two groups.

Eligibility criteria:
inclusion criteria: * age\>18 years. * meeting the diagnostic criteria for ischemic stroke . * dysphagia confirmed by video fluoroscopic swallowing study. * clear consciousness. * stable vital signs. exclusion criteria: * dysphagia that might be caused by other diseases that might cause dysphagia, such as head and neck tumors, traumatic brain injury, etc. * complicated with severe liver and kidney failure, tumors, or hematological disorders. * simultaneously in need to undergo other therapy that might affect the outcomes of this study. * pregnant or nursing females.