Kornimate/medical-research-clean huggingface dataset:
nutrition education program for cancer patients receiving radiotherapy

Conditions: Radiotherapy Side Effect; Nutrition Related Cancer

Summary: using randomized control study, explore the effect of novel nutrition education program on the nutrition status and life quality of cancer patients receiving radiotherapy

weight loss is common among cancer patients, and can be attributed to many causes, including mucositis, inability to ingest or absorb adequate calories because of a problem with the alimentary tract, loss of appetite, and metabolic aberrations. unintentional weight loss may be associated with decreased quality of life (qol) and a poorer prognosis. furthermore, for patients who are already in a catabolic state, the increased metabolic demands associated with anticancer treatment (particularly surgery) further worsen the problem. the novel nutrition program might improve the nutrition status and qol in cancer patients receiving radiotherapy.

Eligibility criteria:
inclusion criteria: 1. patients are diagnosed with cancer and receive radiotherapy, especially in head and neck cancer, lung cancer, or esophageal cancer. 2. patients need nutrition support treatment 3. informed consent exclusion criteria: 1. critical patients or life expectancy \< 12 weeks 2. patients with severe hepatic cirrhosis, chronic obstructive pulmonary disease, chronic renal failure, intestinal obstruction, stroke. 3. unconscious or psychiatric patients 4. patients with communication problems

Keywords: nutrition radiotherapy cancer patients
individualized exploration of aerobic exercise-assisted treatment of depression

Conditions: Depression - Major Depressive Disorder

Summary: the goal of this project is to quantify the relative effectiveness of aerobic exercise monitored by smart wristbands in assisting the treatment of depression and improving cognitive function. it aims to explore the mechanisms through which aerobic exercise exerts its effects using imaging genetics and other methods, and to identify suitable populations for exercise, ultimately providing personalized clinical exercise prescriptions. this study will intervene from a behavioral perspective and also seeks to motivate participants to change and improve their physical activity habits.


Eligibility criteria:
inclusion criteria: 1. aged 18-45 years (including 18 and 45), no gender restriction; 2. meets the diagnostic criteria for depressive disorders according to the diagnostic and statistical manual of mental disorders, fifth edition (dsm-iv); 3. outpatients or inpatients; hamilton depression rating scale 17-item (hamd-17) score ≥ 14; mood disorder questionnaire (mdq) screening negative to exclude bipolar disorder patients; and clinical global impressions-severity (cgi-s) score ≥ 4; 4. maintained on antidepressant treatment for at least 4 weeks or not using antidepressant treatment; 5. written informed consent obtained from the patient. exclusion criteria: 1. diagnosed with other mental disorders, including schizophrenia, bipolar disorder, alcohol or substance abuse/dependence, eating disorders, etc.; 2. individuals with intellectual disabilities or who are unable to cooperate for other reasons, or those lacking or having incomplete civil capacity during the onset of illness; 3. suffering from neurological or organic brain diseases (such as stroke, cerebral hemorrhage, brain tumors, parkinson\&#39;s disease, epilepsy, etc.) and a history of severe traumatic brain injury; 4. suffering from conditions with high exercise risk, such as hypertension or heart disease; 5. currently undergoing systematic psychological therapy; 6. in the 3-minute step test, males with a recovery heart rate \&gt;131 and females with a recovery heart rate \&gt;140; 7. physically restricted individuals unable to participate in physical exercise; 8. physical activity readiness questionnaire (par-q) score ≥ 2; 9. pregnant women or individuals with contraindications to mri examinations; 10. individuals with severe suicidal tendencies or at risk of harming others.

Keywords: aerobic exercise
efficacy of single-shot dexmedetomidine versus placebo in preventing pediatric emergence delirium in strabismus surgery

Conditions: Strabismus; Delirium on Emergence; Pediatric Disorders

Summary: this study is trying to see if using precedex pre-operatively prevents emergence delirium in pediatric (ages 1-7) patients undergoing strabismus surgery.

emergence delirium (ed) is a complex behavioral disturbance characterized by psychomotor agitation, perceptual disturbances, delusions, and disorientation during recovery from general anesthesia. in the population of subjects who undergo strabismus surgery, there are multiple factors that may increase the risk of ed. these include age, typically preschool children aged 1-7 years, rapid surgical times with rapid awakening, use of sevoflurane as the primary anesthetic, and surgically-induced postoperative visual disturbance. the aims of this study are: 1) to examine whether post-induction treatment with an α-2 receptor agonist, precedex (dexmedetomidine), decreases postoperative emergence agitation after strabismus surgery compared to placebo, and 2) to determine whether treatment has any effect on postoperative pain, nausea/vomiting, number of pain-related interventions, and time to pacu discharge. we hypothesize that precedex will attenuate the ed response greater than placebo or a lower dose after strabismus surgery and will reduce pacu pain scores without increasing pacu length of stay. inclusion: i. pediatric patients aged 1-7 years of age ii. american society of anesthesiologists (asa) physical status i-ii iii. no significant laboratory abnormalities exclusion: i. presence of medicated behavioral disorder ii. subjects for which precedex, opiates, benzodiazepines, or inhalational anesthetics are contraindicated iii. parental refusal

Eligibility criteria:
inclusion criteria: * asa physical status of i or ii * male or female, aged 1-7 * has no significant lab abnormalities exclusion criteria: * asa physical status of iii, iv or v * presence of medicated behavioral disorder * subjects for which dexmedetomidine, opiates, benzodiazepines or inhalational anesthetics are contraindicated. * parental refusal

Keywords: strabismus pediatric emergence delirium precedex/dexmedetomidine
effects of a low glycemic index in obese children

Conditions: Obesity

Summary: the objective of this study is to compare the effectiveness of a low-gi diet program and a standard counseling program in the treatment of obese thai children.

obese children aged 9-16 years from king chulalongkorn memorial hospital were randomized to receive instruction either for a low-gi diet (intervention group) or a low-calorie, low-fat diet (control group). both groups were followed-up every month for six months. the primary outcomes were body composition changes during the six-month period, measured by dual x-ray absorptiometry (dexa) and bioelectrical impedance analysis (bia). secondary outcomes were metabolic syndrome risk changes measured by fasting plasma glucose, insulin, and lipid profiles. the adherence to the nutritional education and physical activity recommendation was evaluated by using three-day dietary records (two weekdays and one weekend day) and a physical activity questionnaire at each visit. all participants were examined and counseled about physical activity and life style modification strategies by a pediatrician at every visit.

Eligibility criteria:
inclusion criteria: * children aged between nine to sixteen years old * bmi higher than the international obesity task force cut-off exclusion criteria: * psychological problems * underlying diseases that might affect a weight management program * used drugs associated with weight increment or reduction * attended other weight management programs
pre-exposure prophylaxis acceptability & readiness assessments for toronto gay, bisexual and other men who have sex with men-5

Conditions: HIV; Human Immunodeficiency Virus

Summary: canada continues to see an unrelenting stream of new hiv diagnoses, with a disproportionate burden among gay, bisexual, and other msm in major centers such as toronto. pre-exposure prophylaxis (prep) with oral, daily tenofovir/emtricitabine (tdf/ftc, truvada®) is a novel biomedical approach to hiv prevention shown in the iprex trial to be safe and efficacious in reducing hiv acquisition by 44% among msm, when provided in a comprehensive package of hiv prevention interventions including counseling, testing/treatment of sexually transmitted infections (stis), and condoms. there is now widespread mobilization to assess the feasibility of prep roll-out worldwide, with urgent calls for 'demonstration projects' addressing real-world prep implementation issues. preparatory-5 is canada's first prep demonstration project, and will examine real-world prep implementation issues including acceptability, effectiveness, impact on sexually transmitted infections, and strategies for supporting adherence outside the clinical trial setting. the investigators have also established a comprehensive community-based research program investigating the role of community-based organizations in prep implementation and delivery.


Eligibility criteria:
inclusion criteria: * self-identified man who has sex with men * age 18 years or older * able to communicate in both written and oral english * hiri-msm score greater than or equal to 10 * at least one self-reported unprotected receptive anal sex act over the preceding 6 months * creatinine clearance greater than or equal to 60ml/min by modified diet in renal disease (mdrd) formula * hiv un-infected at screening using standard elisa and western blot testing exclusion criteria: * clinical signs or symptoms suggestive of an hiv seroconversion illness within the last 3 months in the opinion of the investigator * use of pre- or post-exposure prophylaxis within the last 3 months * use of concomitant nephrotoxic drugs * use of concomitant immune modulatory drugs * hepatitis b surface antigen positivity * any condition or concomitant medication portending an increased risk of osteoporosis * enrollment in any other hiv prevention program or trial

Keywords: hiv pre-exposure prophylaxis prep human immunodeficiency virus
using near-infrared spectroscopy (nirs) monitor to noninvasively evaluate hepatic venous saturation

Conditions: Congenital Heart Disease; Arrhythmia

Summary: clinical studies are required to validate the hepatic nirs monitor with other regional and global hemodynamic parameters and to evaluate its clinical use for continuous non-invasive hemodynamic monitoring. using newer nirs sensors the correlation between hepatic regional oxygen saturation and hepatic venous oxygen saturation (svho2) needs to be determined. if found to correlate then the nirs can be used to evaluate early liver transplant failure and/or hepatic artery thrombosis, used as an early marker for shock, and necrotizing enterocolitis, and finally used in the outpatient setting to evaluate patients with chronic liver pathologies. if our validation study finds that nirs monitors are an appropriate marker of hepatic venous saturation then it will lead to further clinical studies.


Eligibility criteria:
inclusion criteria: * all pediatric patients (0-18yrs) undergoing cardiac catheterization by the participating interventional cardiologist at phoenix children's hospital will be recruited for this investigation exclusion criteria: * emergency catheterizations, * procedures in hemodynamically unstable patients, * patients with repeat catheterizations that have already enrolled in the study

Keywords: hepatic blood, cardiac cath, hepatic oxygenation, pediatrics
neuropathic pain and operant conditioning of cutaneous reflexes after sci

Conditions: Spinal Cord Injuries; Neuropathic Pain; Neurological Injury; Pain

Summary: the purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. for this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. the study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).

as part of the larger study of the relationship between reflexes in the leg and the presence of neuropathic pain, the researchers are also recruiting 30 individuals with spinal cord injury (sci) total, 15 individuals with neuropathic pain due to sci and 15 individuals without neuropathic pain. for this portion of the study, there are 2 visits. the first visit will examine cutaneous reflexes in the leg. during the second visit, the study team will assess sensation in the leg and administer questionnaires about pain, functioning, and quality of life. this portion of the study does not involve an intervention. the study will then recruit 15 individuals who will participate in reflex training, as described in the brief summary.

Eligibility criteria:
inclusion criteria: 1. neurologically stable (\>1 year post sci) 2. medical clearance to participate 3. ability to stand with or without an assistive device for at least 3 minutes at a time 4. expectation that current medication will be maintained without change for at least 3 months (stable use of anti-spasticity medication is accepted) 5. for participants with neuropathic pain, the area of neuropathic pain must include lower leg. exclusion criteria: 1. motoneuron injury 2. known cardiac condition 3. medically unstable condition (incl. pregnancy) 4. cognitive impairment 5. uncontrolled peripheral neuropathy 6. frequent use of electrical spinal stimulation (either transcutaneous or epidural) for pain treatment 7. daily use of electrical stimulation to the leg 8. complete lack of cutaneous sensation around foot.

Keywords: neuroplasticity
fit moms- an internet-based postpartum weight loss program

Conditions: Postpartum Weight

Summary: the purpose of this study is to provide weight loss interventions for mothers participating in the wic program, using the internet to deliver weight loss materials.

develop recruitment methods and determine feasibility of recruiting wic postpartum women who meet inclusion criteria. we will collect data on number of individuals screened and reasons for exclusions. establish and examine feasibility and effectiveness of protocol for wic counselors reinforcing adherence to web based program. we will assess frequency with which wic counselors adhere to protocol of reinforcing adherence to web-based program and extent to which any "treatment contamination" occurs between wic counselors and standard care participants.in those randomized to enhanced wic + internet-based postpartum program, examine acceptability, burden, ease of use, frequency of technical problems, and adherence to web-based program (number of logins, message board postings)explore whether the enhanced wic plus internet postpartum weight loss program will produce significantly greater weight losses than standard wic at 2 months. explore whether enhanced wic plus internet postpartum weight loss program will result in greater improvements in eating and exercise behaviors (examined at 0, and 2 months) and psychosocial parameters (i.e., depression, social support, self-efficacy, body image) than standard care.

Eligibility criteria:
inclusion criteria: * age 18-35 years. * delivery within 6-52 weeks * exceed pre-pregnancy weight by at least 6.8 kg (15 pounds) * current bmi \> 22 * english speaking * has computer with internet access * literacy of at least 5th grade reading level exclusion criteria: * pregnant or planning to become pregnant * relocating in the next year * serious medical problem (i.e. heart disease, cancer, renal disease and diabetes), for which physician supervision of diet and exercise prescription is needed.

Keywords: wic weight loss overweight post partum internet based weight loss intervention for mothers in the wic program.
transcutaneous vagal nerve stimulation: influence on mirna, inflammation, cerebral resting state and gastric motility

Conditions: Epilepsy

Summary: randomized, double-blind trial to investigate the influence of a single 4 hours episode of transcutaneous vagal nerve stimulation on the expression of microrna, various cytokines, chemokines, neuropeptides, cerebral resting state and gastric motility in healthy volunteers.

transcutaneous vagal nerve stimulation (tvns) is a non-invasive treatment option for epilepsy. tvns works via electrical stimulation of the vagal nerve in the outer ear area via two steel electrodes and is performed for about 4 hours per day. its mechanism of action is unknown. we hypothesize that expression of microrna (mirna), and/or release of cytokines, chemokines or neuropeptides is involved in the anticonvulsant activity. tvns might also influence the cerebral resting state as measured by functional magnetic resonance imaging (fmri). due to it's anatomical connections, stimulation of the vagal nerve may furthermore result in altered gastric motility. this study aims to detect levels of mirna, cytokines, chemokines and neuropeptides in the blood of healthy volunteers before and after 4 hours of conventional tvns or sham tvns. cerebral resting state and gastric motility will be measured by fmri. to this end, 60 healthy volunteers will be recruited and divided into 2 groups. 30 healthy volunteers will be treated with tvns (25 hz) for 4 hours (tvns group). 30 healthy volunteers will be treated with sham tvns (1 hz) for 4 hours (control group). on day 1 of the study, participants will be randomized to one of the two groups. blood will be drawn from all participants at baseline. both groups receive a standardized breakfast. tvns ear electrodes will be put into place for 4 hours without electrical stimulation. thereafter, blood will be drawn. on day 2 of the study, blood will be drawn, and all participants receive a standardized breakfast again. afterwards, tvns (25 hz) will be performed in participants of the tvns group, and sham tvns (1 hz) will be performed in participants of the control group. tvns or sham tvns end after 4 hours. blood will be drawn immediately after stimulation end. thereafter, mri will be performed in all participants (fmrt resting state, gastric motility). this ends the study for the participant.

Eligibility criteria:
inclusion criteria: * age between 18 and 65 years * written informed consent exclusion criteria: * pregnancy * active implants (like cardiac pacemaker, cochlea implant, implanted vns) * contraindications for mri (e. g. metal fragments, claustrophobia) * skin lesions in the ara of the left ear conch * nickel allergy * drug or alcohol abuse * current acute disease or medical history of chronic disease * participant is under legal guardianship

Keywords: vagus nerve stimulation
study to evaluate safety, tolerability and immunogenicity of vaccine (ub 311) in subjects with alzheimer's disease

Conditions: Alzheimer's Disease

Summary: the purpose of this phase i study is to determine whether the vaccine (ub 311), targeting the amyloid beta peptide (n-terminal amino acids, 1-14), is safe and immunogenic in patients diagnosed with mild or moderate alzheimer's disease (ad). amyloid beta was selected as the target antigen based on supporting evidence of the hypothesis that places the accumulation of amyloid beta at the initiating step of ad.


Eligibility criteria:
inclusion criteria: * diagnosis of mild to moderate alzheimer's disease * mini-mental state examination (mmse) 15-25 * other inclusion criteria apply exclusion criteria: * major psychiatric disorder * severe systemic disease * serious adverse reactions to any vaccine * other exclusion criteria apply

Keywords: alzheimer's disease amyloid beta vaccine
neuroaid ii™ (mlc901) in mild traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: a randomized double-blind, placebo-controlled, multi-center trial to determine the efficacy of neuroaid ii™ (mlc901) in improvement of cognitive functioning of adult patients with long-term cognitive impairment following mild traumatic brain injury (mtbi) and to assess safety of neuroaid™ (mlc901) in these patients.


Eligibility criteria:
inclusion criteria: 1. patient with mild tbi, which occurred 1-12 months prior enrolment to the study. mild tbi is defined as an external force from an incident causing injury to the brain and resulting in an altered level of consciousness. the mtbi diagnosis should be documented. mild tbi is evidenced by any of the following: * best glasgow coma score 13-15 as assessed on scene, on admission and over next 3 days * loss of consciousness for up to 30 minutes * dazed and confused at the time of injury or post-tbi amnesia of \< 24 hours duration. 2. patient experiencing cognitive impairment following injury, determined by the cognitive failures questionnaire score \>30. 3. adult male or female patients aged 18-65 years. 4. the patient has signed an informed consent form (icf) for participation in this study before initiation of study procedures. 5. the patient can understand all protocol requirements, perform the study procedures, and agree to all limitations specified in the protocol. 6. the patient agrees to use adequate contraception methods. exclusion criteria: 1. moderate or severe tbi, determined by best glasgow coma score of \<13 (as assessed on scene, on admission and over next 3 days), or injury requiring neurosurgery (even if surgery was not done) 2. co-existing severe co-morbidity, including end stage renal failure, spinal cord injury, significant substance abuse, severe liver disease, significant mental illnesses, diabetes requiring insulin injections, severe agitation, advanced cancer or other severe conditions with life expectancy of less than 5 years. the decision on significance of the comorbidity for inclusion/exclusion from current study is made by the investigator. 3. current participation in another clinical trial within 30 days. 4. women who are pregnant or who have a positive urine pregnancy test or breast-feeding. 5. not fluent in russian language or have aphasia/dysphasia. 6. no documented evidence of mtbi. 7. known allergy to mlc901/neuroaid ii™ or any of its component ingredients. 8. other medical condition which in the opinion of the principal investigator would place undue risk on the patient if included in the trial or likely to interfere with neuroaid ii™. 9. history of psychic (including depressive) disorders, physical and other factors that do not allow for adequate self-assessment of one's behaviour and for compliance with the protocol requirements, including history of psychiatric disorders. 10. use of hormonal contraceptives, either oral or implant\*.

Keywords: traumatic brain injury randomized double-blind placebo-controlled neuroaid ii™ mlc901 traditional chinese medicine cognitive functioning
comparison of the effects of morton's neuroma on foot pressure distribution and gait parameters in pes planus and pes cavus patients

Conditions: Morton Neuroma; Pes Planus; Pes Cavus

Summary: the aim of our study is to compare the effect of morton's neuroma in feet with pes planus and pes cavus on foot pressure and temporal and spatial gait parameters.


Eligibility criteria:
inclusion criteria: * patients diagnosed with bilateral pes planus or pes cavus * diagnosis of unilateral morton neuroma * confirmation of the diagnosis of morton's neuroma with magnetic resonance imaging (mri) * pain level of the patients during walking is at least 3 according to the visual analogue scale (vas). * volunteer to study over the age of 18 exclusion criteria: * having symptomatic musculoskeletal disease in the lower extremity * having peripheral nervous system disease * presence of rigid deformity in the foot * extremity or contralateral extremity surgery with morton's neuroma * having received physiotherapy in the last 3 months

Keywords: gait foot pressure