Kornimate/medical-research-clean huggingface dataset:
gemzar (gemcitabine) and alimta (pemetrexed) in the treatment of patients with recurrent platinum-sensitive and platinum-resistant ovarian or peritoneal cancer

Conditions: Ovarian Cancer; Peritoneal Cancer

Summary: this study hopes to evaluate whether the combination of gemzar plus alimta will have any beneficial effects for patients with recurrent platinum-sensitive or platinum-resistant ovarian or peritoneal cancer. treatments are weekly for two weeks, with the 3rd week off and will be repeated every 21 days. side effects and the overall safety of the treatment will also be monitored and evaluated. in addition, a quality of life questionnaire is part of this study to help measure patient perceived benefits or drawbacks to this treatment regimen.


Eligibility criteria:
inclusion criteria: * patients must have disease that can be measured. * patients must meet criteria for either platinum-resistant or platinum-sensitive ovarian or peritoneal cancer. * patients may only have had one prior platinum-based chemotherapy regimen. * patients must be willing and able to stop all aspirin and nsaid medications immediately before and for a time after each treatment cycle (approx. 5-8 days) * patients must have normal kidney function. exclusion criteria: * patients may not have a low malignant potential or borderline ovarian tumor. * patients may not have received pelvic or abdominal radiotherapy. * patients must not have evidence of or received treatment for another cancer within the last 5 years. * patients must not have been diagnosed with a heart attack in the last 6 months. * patients who are unwilling or unable to take folic acid tablets, vitamin b12 injections or dexamethasone tablets.

Keywords: recurrent ovarian cancer platinum-resistant platinum-sensitive folate receptor antagonist
pediatric femur research project

Conditions: Femur Fracture

Summary: current treatment protocol for pediatric femoral shaft fractures is immediate spica casting for patients 6 years and younger and for patients over 6 years and older is percutaneous or open placement of titanium elastic intramedullary nails. the investigators would like to evaluate the current treatment protocol by comparing those patients 6 years and younger treated with closed reduction and spica casting to those 6 years and younger treated with percutaneous pinned with titanium elastic intramedullary nails or submuscular plating. the investigators will be comparing their post-operative functional level, pain management, impact on family and complications through chart and x-ray reviews. the goal is to improve patient care pre and post-operatively for those who have sustained a femoral shaft fracture 6 years old and younger and increase the knowledge of those residents/physicians who care for this patient population.


Eligibility criteria:
inclusion criteria: * child diagnosed with femur fracture between the ages of 2-6 years old * patient will undergo surgical intervention for a femur fracture (e.g., submuscular plating, nancy nailing, casting ) exclusion criteria: * parent refusal to participate for any reason * children with neuromuscular disorders having a gross motor function classification greater than 3 * pathologic fracture

Keywords: orthopedic procedures fracture fixation, internal fracture fixation, external femur fracture pediatrics
reading problems in children living in urban areas

Conditions: Dyslexia

Summary: the first line of defense against reading disabilities is good classroom reading instruction. this study describes how characteristics of students, teachers, and instruction relate to academic achievement in inner-city kindergarten through grade 4 classrooms.

recent studies show that the incidence of reading disability can be significantly reduced by improving classroom instruction. effective reading instruction in the primary grades includes explicit instruction in the alphabetic principle, reading for meaning, and opportunities to practice reading and writing. to learn more about the development of literacy skills in urban settings, students in 17 schools in houston and washington, d.c., were followed from kindergarten through grade 4. schools were selected based on similar demographics: predominantly african-american student population (95%) and high participation in the federal lunch program (85% to 100%). each school was provided with grade-appropriate reading programs that focused on phonics and spelling. these programs included direct, integrated, classroom, and individual instruction modules. approximately 1400 children and 114 teachers participated each year in this four-year study. the design was cross-sequential so that the majority of teachers in a grade participated for two years. all children participating in regular education were included in the study. children below the 25th percentile on a standardized reading test were tutored individually by retired teachers, using materials from the classroom reading program. a variety of reading curricula were in place in the classrooms across these two sites. in order to help teachers implement these materials effectively, an ongoing research-based professional development model was employed, with curriculum consultants and coaches working with the teachers in the classroom. researchers observed in each classroom four to six times during the year using on-the-minute recordings of content. observers also completed ratings of teaching competencies. teachers completed surveys of knowledge, experience, attitudes, and instructional strategies. a random selection of eight to ten students were assessed four times during the year for growth in literacy-related skills and once at the end of the year for achievement in reading, spelling, and writing.

Eligibility criteria:
inclusion criteria * student in participating school * kindergarten through grade 4

Keywords: reading disabilities inner-city urban
effect of rosuvastatin on systemic sclerosis-related pulmonary hypertension

Conditions: Systemic Sclerosis

Summary: although the aetiology of ssc-pah remains elusive, vascular dysfunction seems to be the initial event and statins through their vasculoprotective effect might be of value in the treatment armamentarium of pah related to ssc. the aim was to assess the efficacy of rosuvastatin in ameliorating vascular dysfunction and in the management of ssc-related pah.

background: pulmonary arterial hypertension (pah) is an acknowledged devastating complication of systemic sclerosis (ssc); difficult to manage with a poor prognosis. although the aetiology of ssc-pah remains elusive, vascular dysfunction seems to be the initial event. statins, through their pleotropic effects might be of value in the treatment armamentarium of pah related to ssc. objectives: the aim was to assess the efficacy of rosuvastatin in ameliorating vascular dysfunction and in the management of ssc-related pah. methods: forty ssc patients fulfilling the acr criteria for the classification of ssc diagnosis and having pah were recruited. all ssc patients underwent transthoracic echocardiography and the six minute walk test (smwt). patients were randomized into 2 groups; the first group (n = 23) were assigned to receive 40mg of rosuvastatin and the second group (n = 23) received placebo for 6 months. the levels of endothelial dysfunction and inflammatory markers were assayed at baseline and after 6 months of therapy. outcome measures assessed included exercise capacity (smwt), mpap, who functional class change, tolerability and safety.

Eligibility criteria:
inclusion criteria: * new york heart association (nyha) class iii * a mean pulmonary artery pressure (mpap) of \> 30mmhg at rest exclusion criteria: * smoking * diabetes mellitus * hypercholesterolemia * hypertension * cardiac insufficiency * coexisting hepatic and renal diseases * use of drugs known to interact with statins. * patients with severe interstitial lung fibrosis

Keywords: systemic sclerosis pulmonary hypertension rosuvastatin
probiotic and influenza vaccination to reducing influenza-like illness incident in elderly

Conditions: Influenza-like Illness

Summary: to asses the effect of the probiotic and influenza vaccination alone and combination on enhancing immune response to influenza-like illness (ili) and reducing ili incidence in the elderly

to see percetange of subjects seroconvertion and seroprotection before and after intervention in the elderly (\>60 years), and monitored for 6 months.

Eligibility criteria:
inclusion criteria: * all health elderly aged ≥ 60 years * who came to the vaccination and health education activities in the entire east jakarta district health center * with body mass index (bmi) 17,5-29,9 * healthy mental status (mmse score of 28-30) exclusion criteria: * subject who have contraindications to influenza vaccinations * are undergoing treatment related to immune system modulation in the past 4 weeks * therapy for immunossuppresants and/ or corticosteroids eqivalent to prednisone ≥ 20 mg/day that is being lived more than 2 weeks or has only been stopped less than 3 months before the study * recieved influenza vaccination less than one year before * currently consuming probiotic agents, either in the form of a manufacturer or natural for more than 7 days.

Keywords: influenza vaccine probiotic influenza-like illness
defining the role of endothelial function assessment using endopat in cardiovascular risk screening : comparison to traditional risk assessment tools and cimt testing

Conditions: Atherosclerosis

Summary: our study aims to evaluate endothelial function using the non-invasive endopat device, and compare this assessment to traditional cardiovascular risk calculation tools and carotid intima media thickness measurements. we look to determine whether the discovery of endothelial dysfunction provides incremental risk stratification over traditional and cimt methods of cardiovascular risk assessment.

atherosclerosis is a disease affecting the function of arteries, and is one of the underlying causes of stroke, heart attack and other cardiovascular diseases. these diseases are some of the highest causes of morbidity and mortality in north america. as an inflammatory disease that involves the endothelium of blood vessels, atherosclerosis causes arteries to stiffen and become blocked with plaques. this leads to decreased function of these arteries, which at first is asymptomatic, but at later stages can block blood supply to the heart or brain. the endo-pat 2000 is a device designed to measure endothelial function using finger probes placed onto the finger tip of a patient. it is made to detect the presence of peripheral endothelial dysfunction, which develops under the same mechanisms as coronary disease. risk factors for heart disease are well recognized, and include gender, race, weight, smoking status, and the presence of hypertension, diabetes, and elevated cholesterol. while these factors are monitored in the clinical setting, the actual damage to vascular endothelium has previously been difficult to quantify. the endopat system offers a novel method of assessing endothelial function as an aggregate outcome of all of these risk factors.

Eligibility criteria:
inclusion criteria: * all patients 18 years of age and older are eligible exclusion criteria: * none except age \< 18 years
adjunctive game intervention for anhedonia in mdd patients

Conditions: Depression

Summary: this is a pilot study using game intervention as an adjuvant treatment, to evaluate the effect of the video game on anhedonia and associated functional change of brain in patients with depression. participants will be randomized to experimental group receiving a 8-week treatment of antidepressant drugs and game intervention, or control group receiving a 8-week treatment of antidepressant drugs. magnetic resonance imaging scanning and assessment of clinical characteristics and cognitive function were conducted before and after the intervention.

depression is a serious mental health problem that affects millions of people globally. anhedonia, a core symptom of depression, is the loss of pleasure or interest in enjoyable activities. the presence of anhedonia is a risk factor of poor outcome of depression. although some patients reach remission after treatment, anhedonia still persists as a residual symptom. it is generally believed that the frontal-striatal pathway plays an important role in the reward system of brain in patients with depression. the mechanism of anhedonia is closely related to the function of the brain's reward system dopamine. there have been some research showed benefits of playing video games on brain. video games can modulate negative emotions and increase positive feelings. previous studies have confirmed that playing games will activate the release of dopamine in striatum. "dancing line" is a commercial music game. participants need to change the direction of target according to the music by tapping the screen and manage to finish the routes and get the gems along the route as much as possible. sometimes the view of participants would change during the game. the game is simple for participants to pick up and there is no need for prior gaming experience. the main purpose of the study is to explore the effect of game as an adjuvant treatment on anhedonia, depressive symptoms, cognitive function and associated functional change of brain in patients with depression.

Eligibility criteria:
inclusion criteria: * a diagnosis of major depressive disorder according to dsm iv or v and validated via mini international neuropsychiatric interview (m.i.n.i.) * right handedness * capability of understanding and finishing self-rating scales * capability of providing informed consent exclusion criteria: * any other major psychiatric disorders following dsm-5 diagnostic criteria * neurological diseases * a history of drug abuse * suicidal risk * pregnancy * any contraindication for brain mri scan.
immunomodulatory effects of subcutaneous progesterone in patients affected by autoimmune diseases

Conditions: Autoimmune Diseases; Infertility

Summary: this study evaluates the immunomodulatory effects of subcutaneous progesterone in patients undergoing ivf by determination of anti-nuclear antibodies (ana),extractable nuclear antigen antibodies (ena),anti- neutrophil cytoplasmic antibodies(anca),anti-dna antibodies, anti-cardiolipin antibodies (aca),lupus anticoagulant antibodies (lac) and c3 and c4 fractions of complement on the day of beta hcg dosage and during the eigth week of gestation.

the aqueous progesterone preparation for s.c. injection is the first systemic progesterone of its kind for the provision of luteal phase support (lps) in patients undergoing ivf. the the high solubility and rapid absorption of the new preparation are enhanced using cyclodextrins that are starch residues with no therapeutic activity and with a particular molecular structure that closely resembles a 'cap'. once absorbed after injection, the progesterone molecule is immediately dissociated from its cyclodextrin 'cap', remaining free in the circulation as if produced endogenously by the ovaries. in comparison to progesterone-in-oil preparation, the new aqueous solution administered by s.c.route resulted in a 3 fold higher and more rapid progesterone peak serum concentrations. the immunomodulating effects of progesterone are mediated outside of the pelvic cavity, on the peripheral cell of the immune system. for this reason only the injection procedure has this advantage furthermore, the faster absorption rate and the higher peak serum concentration should increas the systemic immunomodulatory effect of subcutaneous progesterone compared to the vaginal and intramuscular administration

Eligibility criteria:
inclusion criteria: * infertile patients affected by autoimmune diseases undergoing ivf exclusion criteria: * infertile patients without autoimmune diseases, fertile patients affected by autoimmune diseases

Keywords: autoimmune diseases and infertility luteal supplementation with subcutaneous progesterone systemic effect of progesterone
effects of diaphragm manual therapy verses sustained natural apophyseal glide in mechanical neck pain

Conditions: Neck Pain

Summary: mechanical neck pain is defined as pain and discomfort localized between the superior nuchal line, cervical spine, and the spinous process of the first thoracic vertebra. some of the most typical factors include continuous use of mobile phones and computers, working in sedentary jobs, etc. study aimed to compare diaphragm manual therapy and sustained natural apophyseal glide on pain, range of motion and functional disability in patients with mechanical neck pain.

this project will be a randomized clinical trial conducted to check the effects of diaphragm manual therapy versus sustained natural apophyseal glide on pain, range of motion and functional disability in patients with mechanical neck pain at sehat medical complex lahore through non-probability convenient sampling technique on 34 patients will be allocated using simple random sampling through computer generated randomization into group a and group b. group a will be treated with diaphragm manual therapy and baseline treatment was given and group b with sustained natural apophyseal glide and baseline treatment was given. all exercise were performed 3 times a week for total 4 weeks. outcome measures will be conducted through nprs for pain, rom measured by goniometer, and neck disability index (ndi) for disability after 4 weeks. data was analyzed during spss software version 25. after assessing the normality of data by the shapiro-wilk test, it decided whether either parametric or non-parametric tests were used within a group or between two groups.

Eligibility criteria:
inclusion criteria: * age group between 18 and 40 years * both gender male and female * individuals having localized pain or stiffness in the cervical spine or both combined between c3 and c7 without upper-limb radiculopathy * pain reported on nprs score ˃3 to \<7/10 in neck region for more than 3 months. * limited neck rom * negative spurling's test, traction test, upper limb tension test, and shoulder abduction test exclusion criteria: patients were excluded if they were diagnosed with the following conditions for ˃6 months * tuberculosis, carcinoma, heart disease, and osteoporosis * neural disorders due to prolapsed intervertebral disc * any trauma or localized infection in neck region * upper motor neuron disease, cervical stenosis, and metabolic diseases in bone and joint * hyper flexibility * open sores * ongoing radiotherapy, chemotherapy, steroid therapy, or anticoagulants * psychiatric diseases such as phobia/obsession and depression * allergy to hot pack * patients with history of surgery in cervical spine region with in a year.

Keywords: disability muscle strength pain range of motion
a study comparing 4 doses of gw810781 versus placebo in hiv-infected patients

Conditions: HIV Infections

Summary: this study will evaluate the drop in viral load over 10 days of treatment with s-1360 versus placebo in hiv-infected patients who have not previously taken anti-hiv medications.


Eligibility criteria:
inclusion criteria: * no prior hiv medications. * hiv infection with viral load \>400-50,000 copies/ml. * cd4 cell count \>50 cells/mm. exclusion criteria: * patients requiring medications that cannot be interrupted for the duration of the study. * abnormal ecg or other chronic health conditions as noted on screening physical exam. * previous participation in an experimental drug trial(s) within 30 days of the screening visit for this study.

Keywords: integrase inhibitors monotherapy hiv-1 infection
host responses in kidney-transplant recipients with chronic hepatitis e virus infection

Conditions: Kidney-transplant Recipients With Chronic Hepatitis E Virus Infection

Summary: hepatitis e is a worldwide disease. it is the leading or second leading cause of acute hepatitis in adults in developing countries from sub-saharan africa or southeast asia, where it is hyperendemic and principally water-borne. in industrialised western countries, hepatitis e was until recently considered as imported from hyperendemic geographical areas, but is currently an emerging autochthonous infectious disease. a growing body of data from europe, america, australia, and asia strongly indicate that pigs represent a major hepatitis e virus (hev) reservoir and might be a source of zoonotic transmission to humans through direct or indirect exposure. hepatitis e typically causes self-limited acute infection. however, the overall death rate is 1-4%, and it can reach 20% in pregnant women and might be still higher in patients with underlying chronic liver disease. to date, no preventive or curative treatment of hepatitis e is available.

therefore, the major goal of the study is to analyse for the first time the host responses in kidney-transplant recipients with chronic hev infection and to compare them to the host responses in kidney-transplant recipients without viral infection (controls), to identify a specific peripheral signature using blood microarray-based gene expression profiling. other minor goals are : 1. to assess the incidence of hev infection in kidney-transplant recipients from south-eastern france, to study the risk factors, and to describe the clinical features and outcomes of chronic hev infection in kidney-transplant recipients, 2. to compare the peripheral signature to a liver signature in the cases where a liver biopsy is available. if peripheral and liver signatures are parallel, peripheral signature may become a non-invasive tool of exploration of chronic hev infection in kidney-transplant recipients.

Eligibility criteria:
inclusion criteria: * age \> 18 years * transplanted by a functional kidney * affected by a hepatitis e chronic * benefiting from a follow-up in the center of nephrology and renal transplantation or in the service of hépato-gastro-entérologie of the chu the conception in marseille * having signed a consent informed about participation in the study exclusion criteria: * affected by another sharp or chronic viral infection