Kornimate/medical-research-clean huggingface dataset:
safety of anticoagulant therapy after tissue glue for gastric varices

Conditions: Anticoagulants and Bleeding Disorders; Tissue Adhesion; Gastric Varices Bleeding

Summary: this study aimed to clarify the safety of anticoagulant therapy after glue injection for cirrhotic variceal bleeding patients with portal vein thrombosis.

acute esophagogastric varices bleeding is a common gastroenterological emergency. and the bleeding from ruptured gastric varices is massive and difficulty to stop, even after aggressive pharmacological and conservative treatment. even after aggressive pharmacological and conservative treatment, maintaining patients without bleeding for a long time is still a challenging clinical problem. endoscopic tissue adhesive injection is recommended by many international guidelines for acute hemostasis and secondary prevention of gastric variceal bleeding. however, postoperative glue extrusion is inevitable, and the the rebleeding caused by glue ulcers is a problem that is often faced in clinical work. in patients with portal vein thrombosis, the need for anticoagulation and the choice of anticoagulant drugs need to be carefully evaluated in terms of risk and benefit, as the dual conflicts of thrombosis and anticoagulation are involved. at present, there is no in-depth study or consensus on the effect of anticoagulation on rebleeding after glue injection in patients with portal vein thrombosis. this study is of great significance for the treatment and prognosis of patients with gastric varices combined with portal vein thrombosis.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of cirrhosis * portal hypertension with gastric varices * diagnosis of pvt by imaging examination * undergo glue injection for gastric varices exclusion criteria: * hepatocellular carcinoma or other extrahepatic malignancy * isolated portal cavernoma * treatment with tips, thrombolysis, thrombectomy or liver transplantation * previous long-term anticoagulation therapy for various reasons * pregnant women * previous endoscopic treatment of gvs

Keywords: anticoagulants tissue glue gastric varices
bicyclol in the treatment of antineoplastic drug-induced liver injury.

Conditions: Drug-Induced Acute Liver Injury

Summary: the clinical trial is designed to evaluate the efficacy of bicyclol for patients with antineoplastic drug-induced liver injury and investigate factors effecting the therapeutic outcome.

this study prospectively studied the treatment of acute drug-induced liver injury related to anti-tumor with bicyclol tablets, to provide medical evidence in clinical practice of bicyclol treating acute drug-induced liver injury. the main purpose of this study is to evaluate the clinical efficacy and outcome of bicyclol tablets in the treatment of drug-induced liver injury and analyze the bicyclol tablet's therapeutic effects in different groups including conventional chemotherapy drugs, targeted drugs, and immunosuppressants. the secondary purpose of this study is to analyze the factors influencing the prognosis and outcome of bicyclol tablets in the treatment of acute dili.

Eligibility criteria:
inclusion criteria: 1. the acute liver injury caused by anti-tumor drugs 2. the rucam assessment scale ≥6 3. the liver injury must in the acute phase 4. must be treated with bicyclol tablets 5. must sign informed consent - exclusion criteria: 1. this acute liver injury caused by non-anti-tumor drugs 2. pregnant women 3. lactating women 4. childbearing age women are plan to conceive

Keywords: prospective study multicenter trials bicyclol tablet antineoplastic drug-induced liver injury
sensory supported swimming for children with asd

Conditions: Autism Spectrum Disorders

Summary: the purpose of sensory supported swimming is to provide a sustainable, low cost recreational swim program for children with asd. a secondary purpose is to train general recreation providers and swim instructors to meet the unique needs of children. specific aims include both program development and research aims as described below. specific aims: 1. provide more opportunities for families of children with asd to access a recreational swim program at low cost. (program development) 2. increase the capacity of swim instructors and general recreation providers working with children with asd. (research) 3. increase physical activity for children with asd in a way that is a good match for their individual sensory needs. (research) 4. increase safety among children with asd in and around the water so they and their families can swim safely. (research) 5. transition swimmers with asd from a learn-to-swim program to an inclusive swim team. (program development) hypotheses 1. the sensory supported swim program will increase physical activity of children with asd. 2. the sensory supported swim program will increase safety of children with asd in and around the water. 3. the sensory supported swim program will increase the capacity of general recreation providers and swim instructors to serve children with asd.

to decrease risk of drowning, increase opportunities to engage in a lifelong sport, and increase the capacity of general recreation providers, investigators developed a recreational swim program for children with asd. the purpose of this program is to provide swimming and water safety instruction for children with asd. a secondary purpose is to train general recreation providers and swim instructors to meet the unique needs of children. research of this program includes investigating the effects of swimming on health outcomes (i.e., fitness, bmi) of children with asd. sss lessons are provided in eight week sessions six times per year. lessons are individualized according to the child's sensory preferences (as measured by the sensory profile). instructors use evidence-based teaching methods (i.e., visual supports, demonstration, peer and video modelling, sensory modifications) to teach swimming and water safety skills. children may enroll for as many sessions as desired. research includes retrospective review of program records.

Eligibility criteria:
inclusion criteria: * autism diagnosis (any autism spectrum diagnosis) * order of response exclusion criteria: * children with sensory impairments (i.e., blindness, deafness) * based on the discretion of the program directors, participants that display aggressive or harmful behaviors may be excluded for safety purposes
total marrow irradiation & autologous stem cell transplantation for relapsed or refractory myeloma

Conditions: Multiple Myeloma

Summary: the investigators hypothesize that conformal radiation will allow the administration of higher doses of external beam radiation to marrow based malignancies than total body irradiation (tbi)without increasing the toxicity to normal tissues beyond that induced by tbi. further,the investigators hypothesize that this will result in an improvement in disease response and disease control for patients with multiple myeloma. this is a dose escalation study of tmi with the primary objective of determining the maximum tolerated dose of tmi when followed by ahsct in patients with relapsed or refractory multiple myeloma.


Eligibility criteria:
inclusion criteria: * a subject must meet all of the following criteria to be eligible for the study. these will be evaluated within the four weeks prior to enrolment. * subject must have primary refractory or relapsed multiple myeloma. * subject must have a measurable serum or urine monoclonal gammopathy at the time of their latest relapse. * subject must meet institutional guidelines for autologous hsct with adequate renal, cardiac, pulmonary and hepatic function. * an autologous hematopoietic stem cell graft containing more than 2.5 x 106 cd34+ cells/kg must be cryopreserved and available for transplantation. * subject must be of age more than 18 and less than 60 years. * subject must have an ecog performance score of 0,1, or 2. * subject must have the ability to comply with the protocol visit schedule and other protocol requirements. exclusion criteria: * a subject meeting any of the following criteria is not eligible for participation in the study: * subject with non-secretory multiple myeloma or any plasma cell disorders other that mm. * subjects that have not received previous therapy with adequate intense corticosteroids for multiple myeloma. * subjects with a severely limited life expectancy by concomitant illness, defined as a life-expectancy of less than 6 months. * subjects who have previously received radiation treatments or other neoplastic disorders. * subjects with a history of non-compliance in other studies. * pregnant or lactating female subjects.

Keywords: relapse refractory
effect of steroids on thrombosis (blood clot formation) and inflammation in patients undergoing hip surgery

Conditions: Total Hip Replacement

Summary: studies have shown that surgery causes some reactions in your body consistent with inflammation. when the inflammation is extensive, it may affect different parts of the body including the lungs. corticosteroids are commonly used to treat inflammation and are different from performance enhancing steroids associated with athletics. the purpose of this study is to determine the influence of low dose steroids given 3 times in a 24 hour period on thrombotic markers (markers that are associated with increased risks of clotting, a possible complication of surgery), interleukin (il)-6 cytokine release (part of the stress response seen with surgery), and urine desmosine levels (a marker of lung injury) in a randomized placebo controlled trial patients undergoing total hip replacement.


Eligibility criteria:
inclusion criteria: * patients undergoing unilateral total hip replacement with drs. douglas padgett, thomas sculco, or edwin su. * patients between the age of 50 and 90 exclusion criteria: * patients on steroid therapy regardless of dose or duration of treatment or those requiring stress-dose steroids preoperatively * patients who are smokers * patients who have diabetes * patients who are \ 90 years of age * patients with history of prior difficulties tolerating corticosteroids
mri assessment of leukemia response to therapy

Conditions: Acute Myelogenous Leukemia

Summary: the purpose of this study is to investigate if a type of magnetic resonance imaging (mri) scan of the bone marrow before the start of standard chemotherapy can predict complete remission of leukemia patients after the therapy. this type of mri scan, called dynamic contrast-enhanced mri (dce-mri), measures bone marrow blood flow. for those patients who do not achieve complete remission status after initial therapy and will be treated with additional therapy, the investigators are also interested in determining if the second mri exam before the additional therapy can predict complete remission. if successfully tested, the mri exam may be used in the future to help with early identification of patients who are unlikely to respond to standard chemotherapy. this will allow for a personalized therapeutic plan to be developed for these patients at an early stage and prevent them from being exposed to toxic and ineffective therapies.


Eligibility criteria:
inclusion criteria: * newly diagnosed or relapsed aml patients, who are scheduled to receive standard induction therapy. * age \> 8 years and requiring no sedation. * patients must not be pregnant * women of childbearing potential must have negative serum pregnancy test performed within 7-days prior to start of study * the subject or subject's legal guardian has the ability to understand and the willingness to sign a written informed consent and/or assent document. a signed study-specific informed consent and/or assent must be obtained prior to any study specific procedures. exclusion criteria: * patients who would be normally excluded from undergoing an mri examination - patients with a pacemaker, aneurysm clip or any other condition that would warrant avoidance of a strong magnetic field. * patients who have known or suspected allergy to gadolinium-based contrast agent. * severe claustrophobia precluding subject from undergoing a mri * patients with acute or chronic kidney dysfunction (estimated glomerular filtration rate (egfr) \< 30ml/min/1.73 m2 as calculated using the modification of diet in renal disease (mdrd) equation) * pregnant women are excluded from this study because of possible risk to the fetus.

Keywords: aml
uterine peristalsis in ivf

Conditions: Infertility, Female

Summary: an observational prospective cohort study to evaluate the effect of uterine peristalsis at the time of embryo transfer on ivf clinical outcomes performed in women's health hospital, assiut university, egypt. women performing fresh or frozen embryo transfer who do not have any uterine abnormalities will be included in the study


Eligibility criteria:
inclusion criteria: * • women undergoing embryo transfer during ivf cycles. * age: between 20 and 40 years. * have at least 1 good quality embryo at the time of transfer * fresh or frozen-thawed cycles. * any stimulation protocol in fresh cycles, or any endometrial preparation protocol for frozen-thawed cycles exclusion criteria: * • women refusing to participate in clinical research. * any uncorrected uterine abnormality, such as septum, myoma, adenomyosis, or polyp * hydrosalpinx without prior disconnection or excision
drug use investigation for humira® - all patient investigation for rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: to clarify the following matters: * unknown adverse reactions (especially clinically significant adverse reactions) * incidence and conditions of occurrence of adverse reactions in the clinical setting * factors that may affect the safety and effectiveness of humira


Eligibility criteria:
inclusion criteria: * all patients prescribed and treated with humira are included in this survey. exclusion criteria: * contraindications according to the package insert: * patients who have serious infections, * patients who have tuberculosis, * patients with a history of hypersensitivity to any ingredient of humira, * patients who have demyelinating disease or with a history of demyelinating disease, * patients who have cardiac failure congestive.

Keywords: rheumatoid arthritis
embryo dna repair capacity project

Conditions: Infertility

Summary: the mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their dna

the main aim of the present study is to investigate the dna repair pathways of preimplantation embryos, examining the events that take place following induction of a dsb at a unique targeted site. the investigators aim to address questions concerning the functionality of the dna repair mechanism(s) in developing embryos, before and after genome activation.

Eligibility criteria:
inclusion criteria: * gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs * ivf couples: any couples proceeding with a routine ivf cycle exclusion criteria: * less than 21 years of age * inability to provide informed consent
efficacy, safety of t2769 in dry eye disease

Conditions: Dry Eye Syndrome

Summary: efficacy of t2769 in dry eye desease

multicenter and open study

Eligibility criteria:
inclusion criteria: * signed and dated informed consent * male or female aged from ≥ 18 years old * known dry eye syndrome requiring artificial tears within the last 3 months prior to study screening exclusion criteria: * best far corrected visual acuity ≤ 2/10 * severe blepharitis severe dry eye
how does a synbiotic supplement affect iron status during iron repletion in iron depleted female athletes?

Conditions: Iron-deficiency

Summary: iron deficiency (id) affects \~30% of female athletes, and its consequences are highly relevant to athletic performance. poor iron (fe) uptake remains a major factor in the development of id. while animal studies suggest that prebiotics may improve fe uptake, this has not been well-studied in humans. the main objective of the proposed study is to determine the effects of synbiotic supplementation on the fe status of id female athletes during fe repletion.

iron deficiency (id) affects \~30% of female athletes, and its consequences are highly relevant to athletic performance. poor iron (fe) uptake remains a major factor in the development of id. while animal studies suggest that prebiotics may improve fe uptake, this has not been well-studied in humans. the main objective of the proposed study is to determine the effects of synbiotic supplementation on the fe status of id female athletes during fe repletion. at the beginning of a training season at a division iii university, the fe status of 28 female athletes (cross-country, lacrosse, basketball, field hockey) was screened. twenty eligible athletes (baseline hgb:12.3±0.9g/dl; sfer:18.1±9.2µg/l) were then randomized to receive either a daily synbiotic supplement (5g prebiotic fiber + 8 billion cfu probiotic b. lactis) or placebo, along with a daily fe supplement (140 mg feso4/d) for 8 weeks using a double-blind design. fe status and body composition were assessed at baseline, mid-point and after the trial. participants were instructed to keep daily logs of supplement intake, physical activity, gi and other symptoms.

Eligibility criteria:
inclusion criteria: * female, \>18 y of age, athlete at marywood university, passed ncaa-required medical screening (e.g. healthy enough to participate in sport). exclusion criteria: * current, acute, chronic illness; severe asthma; pre-existing gi disorders known to affect iron status or aggravated by iron supplementation; not pregnant or breastfeeding; clinically-diagnosed with eating disorder; consuming iron supplement within 4 weeks of screening; hemolytic anemia, excessive alcohol consumption.

Keywords: female athletes iron supplementation prebiotic probiotic synbiotic serum ferritin
role of follicular t cells in hashimoto's thyroiditis

Conditions: Hashimoto's Thyroiditis

Summary: measure the frequency of follicular helper tcells and follicular regulatory t cells in peripheral blood samples in hashimoto's pts in comparison with control.

hashimoto thyroiditis, also known as chronic autoimmune thyroiditis and chronic lymphocytic thyroiditis, is an autoimmune disease in which thyroid cells are destroyed via cell and antibody-mediated immune processes. it is the most common cause of hypothyroidism in developed countries. in contrast, the most common cause of hypothyroidism worldwide is an inadequate dietary intake of iodine. the pathophysiology of hashimoto thyroiditis involves the formation of antithyroid antibodies that attack the thyroid tissue, causing progressive fibrosis. the diagnosis can be challenging, and consequently, the condition is sometimes not diagnosed until late in the disease process. the most common laboratory findings demonstrate elevated thyroid-stimulating hormone (tsh) and low thyroxine (t4) levels, coupled with increased antithyroid peroxidase (anti-tpo) antibodies and antithyroglobulin (anti-tg) antibodies . recent years have shown that hashimoto thyroiditis development depends on an immune defect in an individual with genetic susceptibility together with environmental factors .

Eligibility criteria:
inclusion criteria: - the study will include 45 hashimoto's patients attending the out clinics of endocrinology department of assiut university hospital. in addition, 45 healthy blood donors will be included as controls. the diagnosis of hashimoto's thyroiditis will be determined according to the criteria of american thyroid association; * having symptoms of hypothyroidism, and a blood test shows an underactive thyroid gland \[an elevated thyroid stimulating hormone (tsh) level with or without a low thyroid hormone (free t4 or total t4) level\]. * have elevated thyroid antibody levels. * ultrasound examination demonstrating characteristic heterogeneous echotexture. * results of thyroid fine needle aspiration (fna) examinations meeting ht cytology diagnostic criteria. exclusion criteria: * -we should exclude other causes of thyroiditis, such as de quervain's thyroiditis, riedel's thyroiditis, and suppurative thyroiditis and also exclude other autoimmune diseases for example; type1 diabetes\&rheumatoid arthritis,and other diseases which cause hypothyroidism as carcinoma and surgery.
heat intolerance- a lesson from global genomic response in lymphocytes

Conditions: Heat Intolerance; Genotypic Variations; Gene Expression; Genomic Markers for Predisposition of Heat Intolerance

Summary: heat intolerance (hi) is a life threatening deficiency that can lead to heat exhaustion, heat stroke (and possibly death) in a large number of military and civilian occupational groups. we have demonstrated malfunction of transcriptional pathways in the heat stressed hi phenotype and an altered gene expression profile compared to heat tolerant (ht) individuals. such differences are evident even under normothermic basal/comfort conditions. heat and exercise challenges during the heat tolerance test (htt) further emphasize the differences between the groups, particularly during recovery at comfort temperatures. our results indicate that it may be possible to identify markers of heat intolerance. to achieve this goal, we plan to design a cellular (lymphocyte) htt experimental model and detect gene expression profiles using customized dna microarrays and bioinformatic tools (the genes selected will be based on our previous dna microarray studies). lymphocyte samples collected from ht and hi individuals under resting/comfort conditions will be examined. treatments and analyses are designed to reveal hi-associated gene-expression profiles (constitutive or inducible), and thereby find lymphocyte markers to identify individuals predisposed to heat injury. the identification of such subjects could prevent unnecessary loss of life. notably, the rapidly changing climate in our era increases the number of occupation/age groups in which manifestations of hi will appear.


Eligibility criteria:
inclusion criteria: * experienced heat exhaustion or heat stroke in their past * participating in heat tolerance tests (htt) exclusion criteria: * unambiguous result of the htt * htt stop by the subject decision