Kornimate/medical-research-clean huggingface dataset:
one-stop-shop endoscopy in reflux-patients: evaluation of ent and gi features

Conditions: Reflux Disease; Reflux, Gastroesophageal; Reflux, Laryngopharyngeal

Summary: patients suffering from gastroesophageal reflux may suffer from both esophageal and laryngeal irritations. the investigators developed an endoscopic technique called functional endoscopy to evaluate alterations in the larynx and pharynx as well as in the esophagus simultaneously as one-stop-shop.

patients suffering from gastroesophageal reflux may present to a variety of medical specialists according to their individual complaints (e.g., heartburn, hoarseness, dysphasia). in general, these addressed specialist may focus their attention to their individual fields of interest. the investigators developed an endoscopic technique called functional endoscopy to evaluate patients with various gi- or ent (ear-nose-throat)-symptoms being suggestive for gastroesophageal reflux disease. in functional endoscopy, unsedated patients are examined with an ultrathin endoscope via the transnasal route. reflux-associated features in the field of interest of the ent-doctor and the gi-specialist are recorded and documented in the same session.

Eligibility criteria:
inclusion criteria: - patients suffering from dysphasia, heartburn, laryngitis or pharyngitis suggestive for gastroesophageal reflux disease exclusion criteria: * age under 18 years * inability to understand information for participation * refusal of participation

Keywords: functional endoscopy
effects of inspiratory muscle training in patients with advanced lung disease

Conditions: Lung Diseases; Pulmonary Disease

Summary: the aim of this clinical trial is to evaluate, the effects of inspiratory muscle training program in inspiratory muscle function, functional capacity, quality of life, lung function, breathing pattern and chest wall motion in patients with advanced lung disease. patients were evaluated before the inspiratory muscle training, after 8 weeks of training and at follow-up which was performed 3 months after the end of the intervention.

inspiratory muscle training (imt) should be considered an additional intervention in the pulmonary rehabilitation program for patients with advanced lung disease. the aim of this study is to evaluate, the effects of inspiratory muscle training program in inspiratory muscle function, functional capacity, quality of life, lung function, breathing pattern and chest wall motion in patients with advanced lung disease. it is a quasi-experimental study with longitudinal design. patients with advanced lung disease from the advanced lung disease and pre lung transplantation ambulatory performed home-based high intensity interval imt for 8 weeks (two sessions per day, daily). in each session patients executed two times 30 breaths with one-minute rest between them. resistance was set to the highest tolerable according to scores pointed by the patient on the borg score (between 4 and 6) aiming 50% of actual pimax or higher. an experienced physiotherapist was responsible for weekly adjustments on the resistance of training as well as new assessment of maximal inspiratory pressure. patients were evaluated before the inspiratory muscle training, after 8 weeks of training and at follow-up which was performed 3 months after the end of the intervention. patients were evaluated by the same experienced researcher in all three moments of the study. evaluations were performed in the laboratory of research and evaluation of cardiorespiratory performance of federal university of minas gerais.

Eligibility criteria:
inclusion criteria: * presence of inspiratory muscle weakness (maximal inspiratory pressure - mip ≤ 60 cmh2o or below the reference values proposed for the brazilian population. * completion of a 36 sessions of pr or nonattendance in any pulmonary rehabilitation by the time of inclusion and no perspective of initiating it in the next 8 weeks. * absence of pre-existing neuromuscular, infectious, metabolic, psychiatric diseases or orthopedic problems that prevent from activities of daily living. exclusion criteria: * presented inspiratory muscle strength higher than 60 cmh2o or predicted value * unable to follow commands related to the measurements or to the imt

Keywords: inspiratory muscle training advanced lung disease maximal inspiratory pressure inspiratory endurance
dynamic-orthosis programs for stroke hand function

Conditions: Stroke

Summary: this study aims to investigate the training benefits of modular 3d printed dynamic orthoses on upper limb function in stroke survivors.

this study is a randomized controlled intervention trial. participants are recruited from two medical centers in taiwan and undergo a continuous 6-week intervention for post-stroke movement rehabilitation. the control group receives traditional stroke occupational therapy rehabilitation. the experimental group, in addition to traditional treatment, supplements their therapy with the use of modular 3d printed dynamic orthoses developed by the research team for home training. both groups undergo two effectiveness follow-up assessments, one month and two months after the intervention.

Eligibility criteria:
inclusion criteria: 1. onset of stroke at least three months ago; 2. upper limb brunnstrom stage ii\~iv; 3. shoulder can actively flex at least 45 degrees. exclusion criteria: 1. affected hand has regained autonomous grasping function, able to grasp and release a tennis ball 10 times within 2 minutes; 2. joint deformity or stiffness in the affected hand that prevents the use of the dynamic orthosis; 3. diagnosis of other neurological disorders affecting motor control, such as neglect, parkinson's disease, etc.; 4. inability to follow therapist guidance; 5. currently undergoing other specific treatments affecting motor function recovery (such as rtms and btx).
study to determine the effects of human growth hormone and pioglitazone in overweight, prediabetic adults

Conditions: Obesity; Metabolic Syndrome; Impaired Glucose Tolerance

Summary: the purpose of the study was to determine the effects of growth hormone and an insulin sensitizer drug in pre-diabetic adults with excessive amounts of abdominal fat. participants received a combination of two drugs: (1) recombinant human growth hormone (or its placebo) and (2) pioglitazone (or its placebo). we measured the abdominal fat content and blood sugar levels of participants before and after 40 weeks of treatment.

treatment with recombinant human growth hormone (gh) has been shown to reduce visceral adipose tissue (vat) and improve insulin sensitivity in normoglycemic adults, but glucose levels may rise transiently. pioglitazone, a thiazolidinedione (tzd) drug, counters the short-term diabetogenic effect of gh in rodents, but combined use of these drugs has not been evaluated in humans. the purpose of this study was to determine the effects of gh and a tzd, alone and in combination, on glucose metabolism, visceral adiposity and insulin sensitivity in abdominally obese adults with impaired glucose tolerance. the hypothesis that combined treatment attenuates gh-induced increases in glucose concentrations, reduces vat, and improves insulin sensitivity over time was tested. sixty-two adults received gh and pioglitazone for 40 weeks in a double-blind, randomized, placebo-controlled trial.

Eligibility criteria:
inclusion criteria: * age between 40 and 75 years * bmi \> 27 kg/m2 * waist circumference \>100 cm for men and \> 88 cm for women * impaired glucose tolerance (documented by a 75 gram ogtt) exclusion criteria: * diabetes mellitus * malignancy * premenopausal women who are breastfeeding or decline contraception * congestive heart failure * alt \> 3 times upper normal limit

Keywords: visceral fat impaired glucose tolerance insulin resistance growth hormone thiazolidinedione
predictors of the outcome of late life depression

Conditions: Major Depression

Summary: predictors of response to pharmacological treatment of major depressive disorder will be investigated. one hundred and twenty patients will be included in a naturalistic clinical trial. psychopathology, personality traits, cognitive performance, brain structural changes and genetic polymorphisms will be evaluated. patients will be followed for 18 months with a pharmacological treatment algorithm and will be evaluated monthly until 6th month and every 3 months, up to 18 months. psychoeducation will be offered to patients who did not remit until 3 months of pharmacological tretment.

the relevance of depression prevention and treatment in older people tend to raise in future years, considering the rapid increase of the elderly population in brazil and the growing impact of depression (the third cause of global burden of diseases in the world according to the world health association 2004 report). the association between structural brain changes and treatment response in patients with late-life depression (lld) remains an intriguing area of research. predictors of response to pharmacological treatment of major depressive disorder will be investigated in 120 elderly patients, who will be included in a naturalistic clinical trial, that will evaluate psychopathology, personality traits, cognitive performance, brain structural changes and genetic polymorphisms. patients will be followed for 18 months with a treatment algorithm for depression and will be evaluated monthly until 6th month and every 3 months, up to 18 months, to assess factors associated to response to treatment. patients who are in the antidepressant treatment group and does not reach remission (madrs score \<or =8) until 3 months of pharmacological treatment will be invited to be part of a psychoeducation program. if the patient accepts the psychoeducation intervention, he will be randomized to psychoeducation (pharmacological treatment plus psychoeducation) or treatment as usual (only pharmacological treatment). the psychoeducation program consists of 10 individual weekly sessions, conducted by a trained psychologist who will explain the main concepts of depression and its symptoms, the importance of adhering to treatment, the main side effects of pharmacological treatment, and how to cope with daily difficulties.

Eligibility criteria:
inclusion criteria: * 60 years old * major depression (dsmiv-tr) * evaluated with mini * willing to participate. exclusion criteria: * less than 60 years old * dementia syndrome * delirium or other organic mental disorders * alcohol/drug dependence * anxiety disorders, or other psychiatric disorders, and not willing (or not able) to participate

Keywords: depression elderly remission treatment response predictors of response cognitive decline structural neuroimage genetic polymorphism psychoeducation
cash transfers to increase dietary diversity in grand gedeh county, liberia

Conditions: Malnutrition, Child

Summary: the investigators aim to evaluate the efficacy of a cash transfer and nutrition education program delivered by community health assistants to increase dietary diversity among children 6 to 23 months of age in grand gedeh county, liberia.

worldwide, more than one in five children suffer from chronic malnutrition. in liberia, there are more than 230,000 children suffering from chronic malnutrition and 32% of children under five are stunted. previous studies have shown that inadequate dietary diversity is strongly associated with stunting in children under two years of age. an interventional package including cash transfers and education has the potential to improve dietary diversity and long-term outcomes such as improved growth and reduced rates of stunting among children. the investigators' objective is to evaluate the efficacy of a cash transfer and nutrition education program delivered by community health assistants to increase dietary diversity among children 6 to 23 months of age in grand gedeh county, liberia. the investigators will conduct a pilot, cluster randomized trial in 45 communities. the investigators hypothesize that a multi-pronged interventional package aimed at strengthening the household environment will result in improved dietary diversity for children 6 to 23 months of age. moreover, the investigators also hypothesize that unconditional cash transfers will result in improved dietary diversity for children 6 to 23 months of age in grand gedeh county, liberia.

Eligibility criteria:
inclusion criteria: * participants 6 to 23 months of age * participants with consenting caregivers to have monthly visits and to participate in the program * caregivers of all ages will be included exclusion criteria: * participants who are younger than 6 months of age (children \< 6 months of age are encouraged to exclusively breastfeed, making dietary diversity irrelevant in this age group) * participants older than 23 months of age * participants with non-consenting caregivers

Keywords: cash transfers liberia stunting dietary diversity
icbt for adolescents with co-morbid insomnia

Conditions: Dyssomnias

Summary: insomnia is a commonly reported comorbidity for adolescents with psychiatric conditions. it is well-known that insomnia can exacerbate the concurrent psychiatric symptom load. treatment of insomnia has been extensively examined in adults, but studies with adolescents are sparse. the purpose of this pilot study is to assess the feasibility and efficacy of internet-based cognitive behavioral therapy for insomnia (icbt) in outpatients of children and youth psychiatry. twenty-one adolescents will be recruited and receive 7 weeks of icbt. outcome will be measured at pre treatment, at post treatment and at a three months follow-up. weekly assessments will also be made during treatment on primary outcome and a presumed process variable constructed for the purpose of this trial.


Eligibility criteria:
inclusion criteria: * to fulfill the diagnostic criteria for insomnia * to have access to a computer with internet connection * no previous or ongoing cbt for insomnia * no psychotropic medication or being on a stable dosage for at least six weeks before enrollment exclusion criteria: * ongoing manic or psychotic episode * being at high risk of triggering manic or psychotic episode * ongoing sleep apnea

Keywords: cbt internet based
research of revascularization in immature teeth with periapical periodontitis

Conditions: Periapical Periodontitis

Summary: revascularization is an alternative new treatment of immature permanent teeth with necrotic pulp nowadays while apexification is the traditional therapy. the investigators suppose that revascularization is superior to apexification at developing the root of immature permanent teeth and reducing the risk of root fracture,and the research is designed.

the investigators design to collect a group of patients presenting immature permanent teeth with periapical periodontitis in certain criterion. the investigators will divide the patients into two groups randomly. one group will get treated with revascularization while the other with apexification. the investigators want to evaluate the short-term and long-term effects of the two groups to get a conclusion of the clinical value of revascularization.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of periapical periodontitis * must be immature permanent teeth * must be local guangzhou exclusion criteria: * blood disease * residual root that is advised to extract * serious periodontitis * women in pregnancy

Keywords: immature permanent teeth
gut microbiota and metabonomics

Conditions: Stomach Neoplasms; Gut Microbiota; Metabolomics

Summary: to evaluate the correlation between gut microbiota and metabolites in borrmann type iv gastric cancer; to find the effects of microflora and metabolites on target organs; to detect the mechanism of key flora and metabolite by in vitro and in vivo experiments; to construct models of gut microbiota and metabonomics by machine learning.


Eligibility criteria:
inclusion criteria: 1. patients who sign informed consent. 2. borrmann classification of gastric cancer is determined by more than 2 pathologists. 3. patients with bmi 24-28. 4. karnofsky (kps) score \>80. exclusion criteria: 1. patients who take any aspirin, antibiotics, prebiotics, or probiotics within 4 weeks and steroids or immunosuppressants within 6 months prior to specimen collection. 2. patients who complicate with other malignant tumors. 3. patients who complicate with diabetes, hypertension, heart disease and infectious diseases. 4. patients who complicate with inflammatory bowel disease or irritable bowel syndrome. 5. patients with metastasis.
morbid obesity and severe knee osteoarthritis - which should be treated first?

Conditions: Osteoarthritis of Knee; Arthroplasties, Knee Replacement; Sleeve Gastrectomy

Summary: the goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures. participants will be randomly placed in one of two groups, with each undergoing both procedures but in opposite order. quality of life will be assessed via questionnaires before and between each procedure, and rates of complications will also be documented to compare their rates between groups.


Eligibility criteria:
inclusion criteria: * bmi \> or = 35, on surgical waitlist for a total knee arthroplasty and laparoscopic sleeve gastrectomy exclusion criteria: * a history of revision surgery, surgery for neoplastic disease, significant mental illness, asa class \> 3 denoting absence of significant impact of comorbidities, and previous esophagogastric surgery.

Keywords: knee osteoarthritis bariatric surgery laparoscopic sleeve gastrectomy knee replacement knee arthroplasty obesity
resected lymph nodes and survival of patients with esophageal squamous cell carcinoma: an observational study

Conditions: the Records of Esophageal Cancer

Summary: to clarify the effect of the number of lymph node dissection and the number of stations on survival


Eligibility criteria:
inclusion criteria: 1. men and women aged 18-85; 2. histologically confirmed primary thoracic esophageal squamous cell carcinoma, 3. staging pt1-4a, n0-3, m0 ajcc eighth edition; 4. excluding lymph node dissection \< 15,(meeting the guideline criteria) exclusion criteria: 1. patients with a history of previous thoracic and abdominal surgery that may affect lymphatic reflux 2. patients with distant metastasis confirmed by imaging; 3. patients with obvious surgical contraindications.

Keywords: esophageal cancer lympha nodes
etoricoxib vs. diclofenac in oa (0663-805)(completed)

Conditions: Osteoarthritis

Summary: to compare the safety and tolerability of etoricoxib and diclofenac sodium in the treatment of osteoarthritis of the knee or hip during a six week period.


Eligibility criteria:
inclusion criteria: * patient is at least 40 years old and diagnosed with osteoarthritis of the knee or hip * has a history of treatment with nsaids with positive therapeutic benefit * agree to limit alcohol intake to less than 7 drinks per week and avoid unusual strenuous activity * females who are able to have children must have negative urine pregnancy tests exclusion criteria: * has rheumatoid arthritis, lupus, paget's disease affecting the study joint, or wilson's disease * history of acute ligament or meniscus damage to the study joint (knee or hip) within the past 2 years or arthroscopic surgery on the affected study joint with the past 6 months * requires joint replacement
combination of taliderm® and vacuum-assisted closure (vac) for treatment of pressure ulcers

Conditions: Wounds; Pressure Ulcer

Summary: background: the wound healing promoting effect of negative wound pressure therapies (nwpt) takes place at the wound foam interface. implementation of bioactive substances at this site represents a major research area for the development of future nwpt devices. methods: wound healing kinetics of pressure ulcers treated by vacuum assisted closure devices with or without the implementation of a thin interface of poly-n-acetyl glucosamine nanofibers (snag) was studied in a prospective randomized clinical trial.


Eligibility criteria:
inclusion criteria: * ischial/sacral pressure ulcer between 4 and 15cm diameter * greater than or equal to 18 years of age * ability to obtain informed consent exclusion criteria: * connective tissue disorders * immunosuppression, hemodialysis, steroids * pregnancy * sepsis
effect narrow-band uvb radiations

Conditions: Psoriasis Vulgaris; UVB Phototherapy Burn

Summary: narrow-band uvr affects interleukin 17 which has a major role in the pathogenesis of psoriasis vulgaris. the aim of this study to evaluate the serum levels of interleukin 17 in psoriatic patients and compare with the levels in healthy controls \& evaluate the effect of narrow-band ultraviolet b (nb-uvb) on the serum of interleukin 17 and the treatment of psoriasis vulgaris.

nowadays interleukin 17 has a major role in the pathogenesis of psoriasis vulgaris. the aim of this study to evaluate the serum levels of interleukin 17 in psoriatic patients and compare them with the levels in healthy controls \& evaluate the effect of narrow-band ultraviolet b (nb-uvb) on the serum of interleukin 17 and the treatment of psoriasis vulgaris. this prospective randomized clinical trial was carried out in dermatology department, south valley university hospitals included from september 2020 to august 2021, enrolled 40 psoriatic patients and 40 controls. the study was submitted for approval from the scientific and ethical committees and coded as ( svu.med.dva021, code 1, n 76). forty patients were treated with nb-uvb by starting the dose from 0.5 mj/cm2 for all cases (skin phototypes iii or iv). the dosage is subsequently increased by 20 % per session. sessions were given three times weekly on non-consecutive days for 12 weeks (three months). serum interleukin 17 levels were measured pre-and post-12 weeks narrow-band ultraviolet b by performing an enzyme-linked immune sorbent assay (elisa). main outcome and measures: improvement of psoriasis severity index score after 12 weeks narrow- band uvr treatment and serum-decreased il17 by performing an enzyme-linked immune sorbent assay (elisa).

Eligibility criteria:
inclusion criteria: * patients with psoriasis diagnosed clinically exclusion criteria: * patient with history of skin cancer. patient with history of photosensitivity. patient receiving immune suppressive drugs .

Keywords: psoriasis vulgaris uvb radiations interleukin 17
abrocitinib taiwan treatment pattern and real world study in atopic dermatitis (attract registry)

Conditions: Dermatitis, Atopic; Dermatitis; Eczema; Skin Diseases; Immune System Diseases; Janus Kinase Inhibitors

Summary: this study is to describe the real-world treatment patterns and clinical outcomes in moderate-to-severe ad patients receiving abrocitinib over a 12-month observation period, and to describe patient demographic and baseline characteristics.


Eligibility criteria:
inclusion criteria: patients must meet all of the following inclusion criteria to be eligible for inclusion in the study: 1. patients aged ≥12 years 2. patients with confirmed diagnosis of moderate-to-severe ad as assessed by the physician 3. patients for whom the physician's decision has been made to newly prescribe abrocitinib in usual clinical practice conditions 4. evidence of a personally signed and dated informed consent/assent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study exclusion criteria: patients meeting any of the following criteria will not be included in the study: 1. any prior use of abrocitinib 2. simultaneous participation in a study that includes administration of any investigational drug or procedure

Keywords: atopic dermatitis abrocitinib jak inhibitors real world registry taiwan