Kornimate/medical-research-clean huggingface dataset:
edwards sapien 3 ppi registry

Conditions: Aortic Valve Stenosis; AV Block; Bundle-Branch Block

Summary: there are patient related risk factors for ppi that can be identified and assessed in retrospective pooling of 1000+ tavi patient datasets. retrospective pooling of 6 datasets already available at participating centres (4 sites in germany, 1 in zwolle / the netherlands, 1 in linköping / sweden). additional assessment of calcifications using a ct data core lab. statistical analysis of the obtained dataset with respect to the objectives of the registry.

permanent pacemaker implantation is a widely recognized clinical event associated with tavi becoming evident within a few days after the procedure. while a number of registries have documented the rates of ppi with different valves, much less evidence has been provided for 1) patient based characteristics (e.g. rbbb etc.) affecting the likelihood of ppi and for 2) procedural variables (e.g. implantation depth, valve size etc.) that should be considered to perform an as safe and minimal invasive procedure as possible. prior research to date there are 7 published reports on pacemaker rates and predictors associated with the use of the edwards sapien 3 thv (see table). these studies suggest that the need for pacemaker implantation in single centers ranges between 14.4 and 20.4% derived from patient numbers between 131 and 335. these analyses resulted in the identification of pre-existing conduction disturbance / aortic valve calcification as patient related and implantation depth /oversizing as procedure related variables associated with edwards sapien 3 thv tavi. furthermore a scoring algorithm for patient related factors has been proposed from a dataset of 240 patients to predict the likelihood of ppi after thv . limitations of prior research current evidence though is limited by patient numbers versus event rates (with a max. of 62 ppi considered in any of the available datasets) resulting in a limited power in multivariable analyses, the single center design of these ventures, the lack of a consistent definition of variables potentially associated and the unexplained differences in the number and type of variables identified. aims for this reason the investigators consider it necessary to 1) to retrospectively pool data from all of these 7 datasets to arrive at a more comprehensive picture of patient related variables (retrospective part i), to 2) assess procedural variables in a prospective multicenter registry (prospective part ii) and 3) to potentially validate the identified variables in a future prospective cohort.

Eligibility criteria:
inclusion criteria: * patients that already underwent edwards sapien 3 implantation because of aortic stenosis exclusion criteria: * patients with prior pacemaker or intended valve in valve implantation

Keywords: transcatheter aortic valve implantation pacemaker aortic valve calcification ppi
caudal epidural steroid and trigger point injection

Conditions: Myofascial Trigger Point Pain

Summary: this prospective randomized study will be conducted in bolu abant i̇zzet baysal university hospital. chronic low back and hip pain 72 patients aged between 18-70 years will be included in the study. the primary output of our study was nrs scores. the study of manchikanti. l et al. (control group nrs reduction 4.4 ± 1.8; α margin of error 0.05, power 99%) (3) was taken as the basis for determining the sample size. using the g power 3 calculator program, 72 patients were identified to reduce their nrs scores by 25%. with a 20% exclusion rate, the total number of patients was calculated as 90

demographic information of all patients included in the study; name, surname, telephone number, age, gender, educational status, profession, and marital status will be recorded. the duration of the pain, the onset of the pain, the accompanying leg pain, the activities that increase or decrease the pain, the presence of neurological symptoms, the analgesic agents used in the last week, and the previous treatments will be noted. lumbar mri findings and the level of pathology causing low back and hip pain will be recorded. history, family history, comorbidities (hypertension, diabetes mellitus, hyperlipidemia, cardiac disease, hypothyroidism), and detailed physical examinations of the patients will be recorded. examinations of the patients before and 3, 6, and 12 weeks after the injection will be performed, and nrs scores at 3 and 6 weeks. the procedures will be repeated for patients who are over 4 years old. during the pre-procedural evaluation, the patients will be informed about the study, information about the numeric rating score (nrs), oswestry disability index (odi), short form-36 (sf-36) to be used for post-procedure analgesia, and both verbal and written consents will be obtained. the staff who will make the evaluation will not know which group the patients belong to, and the study will be blinded.

Eligibility criteria:
inclusion criteria: * low back or leg pain that has been going on for at least 2 months, * patients between the ages of 18-70, * disc herniation or radiculopathy in lumbar mri examination .to be mentally competent to understand and evaluate nrs, odi, and sf-36 forms. exclusion criteria * being pregnant or lactating, * presence of spinal canal stenosis, * the presence of bleeding diathesis, * presence of disease with progressive neurological deficit, * the presence of serious psychiatric illness, * presence of progressive neurological deficit or incontinence, * having an epidural steroid injection in the last 6 months, having uncontrolled diabetes mellitus having hypertension, * known history of allergy to local anesthetics or corticosteroids, * the patient does not want treatment, * local infection at the injection site, * infections such as discitis, spondylodiscitis, and sacroiliitis.

Keywords: caudal epidural steroid injection trigger point injection nrs score
assessment of the efficacy of topical curcumin in treatment of oral lichen planus

Conditions: Oral Lichen Planus

Summary: to evaluate the therapeutic impact of curcumin as alternative or complementary to triamcinolone acetonate in treatment of oral lichen planus.

background: oral lichen planus (olp) is a chronic inflammatory disorder affecting the mucous membranes, believed to be an immune-mediated condition. its persisting nature can lead to extended discomfort for those affected. the primary symptoms are pain and a burning sensation, with a potential risk of malignancy if not properly managed, necessitating lifelong clinical monitoring. presently, olp is considered a significant challenge due to the absence of a definitive cure. patients \& patients: thirty patients with oral lichen planus were divided into three groups, 10 patients each: group a: ten patients with olp were received topical triamcinolone acetonide. group b: ten patients with olp were received topical curcumin. group c: ten patients with oral lichen planus were received topical triamcinolone acetonide combiend with topical curcumin. for six weeks. each patient was examined at baseline,1 and 3months of therapy. pain was scored using the visual analogue scale. salivary level of interleukin 1 were estimated at baseline,1and 3 months' evaluation periods.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of olp exclusion criteria: * any systemic autoimmune disease * any current use of anticoagulant or antiplatelet agents (curcumin has inhibitory effects on platelet aggregations). * any topical, local or systemic corticosteroids therapy during the past 3 months. * lichenoid reaction from medications. * pregnant or lactation women. * smokers

Keywords: oral lichen planus immune mediated condition topical curcumin interlukin 6 eliza topical triamcinolone acetonide
improved patient safety through continuous bi-channel rr and spo2 monitoring with masimo patient safetynet

Conditions: Signs and Symptoms, Respiratory

Summary: the investigator intend to perform an observational study, by adding respiratory rate monitoring to an already existing patient safetynet system with spo2 (oxygen saturation) and pr (pulse rate) monitoring. rra will be blinded to the clinicians and all rra alarms will be deactivated. retrospective analysis of the observational data collected will be utilized to evaluate the potential benefits of additional continuous respiratory rate monitoring.

addition of acoustic respiratory rate monitoring to an already existing standard of care patient surveillance system that includes oxygen saturation and heart rate monitoring by pulse oximetry will result in earlier and more sensitive detection of respiratory events and possibly early stages of developing sepsis in a post-surgical/orthopedic study population. an observational study with rra is an additional blinded parameter to the already existing standard of care monitoring with spo2 and pr on one post-surgical floor, (includes trauma and orthopedic patients), where patients receive opioids for pain management. 300 consecutive patients will be enrolled and monitored with rra for at least the first 24hours post-surgery, after discharge from the recovery room, \& upon admission to the surgical floor.

Eligibility criteria:
inclusion criteria: * • adult 18yrs of age or older * post-surgical patient receiving opioid pain medication exclusion criteria: * • refusal of optical finger sensor and/or acoustic respiratory rate neck sensor placement * finger or skin abnormalities at sensor sites * expected opioid therapy duration less than 24 hours

Keywords: early detection respiratory events sepsis
caudal epidural block versus ultrasound-guided pudendal nerve block for pediatric circumcision

Conditions: Circumcision

Summary: the regional anesthesia methods of caudal epidural block (ceb) and dorsal penile nerve block (dpnb) play an important role in providing postoperative pain control in pediatric circumcision surgery. however, the short-term postoperative analgesic effect and the risk of block failure limit the use of dpnb, a peripheral nerve block.

ceb is a neuraxial block and commonly used to control moderate and severe postoperative pain following surgery related to the lumbosacral and midthoracic dermatomes. ceb can have serious undesirable complications such as intravascular and subarachnoid injection, urinary retention and motor block. pudendal nerve block can be used as an alternative to both dpnb and ceb for penile surgery such as circumcision. the pudendal nerve is a peripheral nerve combining the anterior rami of the sacral plexus nerves (s2-s4) and provides motor and sensory innervation to the perineal region.

Eligibility criteria:
inclusion criteria: * male patients aged between 4-12 years * asa (american society of anesthesiologists) i-ii group * scheduled for circumcision * able to communicate in turkish * willing to participate to the study (parents and children) exclusion criteria: * patients aged less than 4 or more than 12 years * neurological deficit * bleeding diathesis * history of local anesthetic allergy * current infection or redness in the region to be injected * congenital lower back anomaly * liver disease * psychiatric disorder * mental retardation * communication problem * refusal to participate in the study.

Keywords: ultrasound pudendal nerve block caudal epidural block pain
frailty, cognitive function and health-related quality of life in older adults with advanced chronic kidney disease.

Conditions: CKD Stage 4; CKD Stage 5; Frailty; Cognitive Impairment

Summary: this observational study explores the impact of cognitive impairment and frailty in older adults with advanced chronic kidney disease \]. the main question\[s\] it aims to answer are: * what determines the time to initiate dialysis? cognitive impairment or frailty? * what does predict the time to death? presence of frailty or cognitive impairment? * what does correlate strongly with time-low health-related quality of life? frailty or cognitive impairment?


Eligibility criteria:
inclusion criteria: * patients age 65 years or older. * ckd stage 4 and 5 who were identified by two consecutive measurements of estimated glomerular filtration rate (egfr) \<30 ml/min/1.73 m2 separated by more than 3 months. exclusion criteria: * patients younger than 65 years old. * chronic kidney disease stages 1,2, and 3. * dialysis dependence * history of kidney transplantation. * initial visit with the health care provider. * recent acute kidney injury. * patients who had been hospitalized for more than 2 months before the visit (because long hospitalization might affect the degree of frailty) * patients with myocardial infarction and cerebrovascular accident 3 months before the assessment * patients who are blind or with limb amputation. * patients who refuse to participate.

Keywords: ckd frailty hrqol
mcneill dysphagia therapy program combined with transcranial magnetic stimulation

Conditions: Dysphagia

Summary: this study aimed to investigate the effectiveness of the mcneill dysphagia therapy (mdtp) programme combined with transcranial magnetic stimulation (tms) in individuals with post-stroke dysphagia.

stroke is a neurological disorder that causes focal or global cerebral dysfunction caused by vascular causes, can last for 24 hours or longer, or may result in death. many complications occur after stroke, and one of the most common complications is dysphagia after dysphagia, individuals with dehydration, malnutrition, aspiration, aspiration-related pneumonia, sepsis, and even death may result if no precautions are taken. purpose of dysphagia treatment; it is to ensure that individuals receive their daily water and calorie needs most reliably. another goal is to switch the patient to oral nutrition as much as possible. mcneill dysphagia therapy programme is a systematic exercise-based therapy program developed for individuals with dysphagia. it is also frequently used in the rehabilitation of stroke, traumatic brain injury, and post-cancer dysphagia. transcranial magnetic stimulation (tms) is based on the principle of electromagnetic induction. it is a non-invasive method that, together with the magnetic field created by a coil placed on the scalp, causes electrical stimulation in the cerebral cortex and creates neurophysiological arrangements in different parts of the brain. without the electrode, electrical energy is transferred to the human brain and the cerebral cortex is stimulated. an action potential is created by stimulation in neuronal membranes and causes neurons to fire. thus, nerve cells are stimulated and the process of reorganization of the brain begins. with the stimulation of the cerebral cortex, the swallowing centre is stimulated and the muscles associated with swallowing are activated. the efficacy of mdtp combined with r tms, mdtp combined with sham r tms and r tms alone will be compared in the intervention of dysphagia after stroke. patients in all three groups will be subjected to both clinical assessment tools and instrumental evaluation before and after treatment. data will be evaluated using the mann swallowing ability assessment test, penetration aspiration scale, functional oral intake scale, visual analogue scale, dynamic rating scale of swallowing toxicity, dysphagia severity rating scale

Eligibility criteria:
inclusion criteria: dysphagia diagnosis of ischaemic stroke over 18 years old cognitively competent and co-operative exclusion criteria: epilepsy or seizure risk record carry metallic objects in the head (such as arterial clips, plates, screws), eye or brain
c1 esterase inhibitor (c1inh-nf) for the treatment of acute hereditary angioedema (hae) attacks

Conditions: Hereditary Angioedema

Summary: the study objective was to determine the safety and efficacy of c1inh-nf for the treatment of acute hae attacks.

randomized subjects treated for a qualifying attack were eligible to receive rescue dosing with 1,000 u of c1inh-nf if they did not achieve beginning of substantial relief of the defining symptom within 4 hours after initial treatment with blinded study drug, or if at any time the attack progressed to include airway compromise. a second 1,000 u rescue dose was permitted 60 minutes after the initial rescue dose, if necessary. the study design also allowed for administration of open-label c1inh-nf for laryngeal angioedema attacks, which were non-randomizable events due to the presence of or potential for airway compromise (immediate 1,000 u dose of c1inh-nf, repeated after 60 minutes, if necessary). in addition, subjects were eligible to receive open-label c1inh-nf (1,000 u single dose) prior to emergency surgical (non-cosmetic) procedures. a total of 83 subjects were enrolled in the study. seventy-one (71) subjects experienced qualifying attacks and were randomized to blinded study drug (36 c1inh-nf, 35 placebo); only the 71 randomized subjects were analyzed for efficacy. an additional 12 subjects were never randomized but received open-label c1inh-nf for treatment of laryngeal angioedema and/or prior to emergency surgical procedures. of the 35 subjects randomized to placebo, 23 also received c1inh-nf (eg, rescue, open-label). in total, 83 subjects received at least 1 dose of study drug and were analyzed for safety; 71 subjects were exposed to c1inh-nf (59 randomized, 12 open-label only) and 12 subjects were exposed only to placebo.

Eligibility criteria:
inclusion criteria: * documented hae * normal c1q level exclusion criteria: * low c1q level * b-cell malignancy * presence of anti-c1inh autoantibody * history of allergic reaction to c1inh or other blood products * narcotic addiction * current participation in any other investigational drug study or within the past 30 days * participation in a c1 esterase inhibitor trial, or received blood or a blood product in the past 90 days * pregnancy or lactation * any clinically significant medical condition, such as renal failure, that in the opinion of the investigator would interfere with the subject's ability to participate in the study

Keywords: hereditary angioedema hae c1 esterase inhibitor (human) c1inh-nf
total knee arthroplasty utilizing adductor canal block: effect on quadriceps sparing

Conditions: Osteoarthritis (Knee)

Summary: the purpose of this study is to investigate whether there is quantitative motor-sparing of the quadriceps muscles following adductor canal nerve block versus femoral nerve block. patients will be randomly placed into one of three treatment groups: 1) femoral nerve block, 2) adductor canal nerve block - low volume, or 3) adductor canal nerve block - high volume. quadriceps function will be assessed in the operating room using a skin patch and electrical stimulation. follow up visits with the patients will continue over the course of 2 days during patient's stay at the hospital. a total of 60 patients will be enrolled for the study.


Eligibility criteria:
inclusion criteria: * all patients undergoing primary unilateral total knee arthroplasty * planned use of combined spinal epidural (cse) anesthesia * ability to follow study protocol exclusion criteria: * contraindication to a spinal or epidural anesthetic * chronic opioid use (defined as daily or almost daily use of opioids for \>3 months) * allergy to local anesthetics * pre-existing neuropathy or weakness of the operative limb * any neuromuscular disorder * diabetes type i and ii * contraindication to a femoral nerve block or adductor canal nerve block * allergy or intolerance to any of the study medications * bmi \> 35 kg/m2

Keywords: adductor canal femoral quadriceps
haptic neurofeedback design for stroke

Conditions: Stroke

Summary: interventional study with minimal risks and constraints, prospective, monocentric.

many patients with stroke have a severe motor deficit in the upper limb impacting their independence. electroencephalogram (eeg) neurofeedback is a re-education technique that improves cerebral plasticity and motor gain in these people during the chronic phase of stroke. the visual feedback usually used tends to diminish the subject's attentional resources, while the proprioceptive feedbacks appear to be more effective on cortical excitability. vibration feedback inducing movement illusion has been shown to be effective in healthy subjects, but has not been tested in people with stroke.

Eligibility criteria:
inclusion criteria: * healthy volunteers : major (age greater than or equal to 18 years) and under 80 years; free, informed and written consent signed by the volunteer; absence of clinical neurological antecedents that can interact with the achievement of the motor task or with the eeg signal. * patients after stroke : major (age greater than or equal to 18 years) and under 80 years;ischemic or unilateral cerebral hemorrhagic hemorrhagic attack;stroke dating back more than 6 months (considered as a delay where recovery of the upper limb to wait is less with conventional rehabilitation);mild to severe upper limb deficiency: fma-eu score ≤ 60; free, informed and written consent signed by the patient or a member of his entourage (in the case of a patient able to understand the information and to express his / her consent but presenting motor difficulties leading to an invalid signature). exclusion criteria: * healthy volunteers : major persons subject to legal protection, persons deprived of their liberty * patients after stroke : ischemic or hemorrhagic involvement of posterior fossa (brainstem, cerebellum);complete motor deficiency of the upper limb (fma-ue = 0);epicritic and proprioceptive anesthesia;understanding difficulties limiting participation in the study;major persons subject to legal protection, persons deprived of their liberty

Keywords: stroke neurofeedback tendon vibration virtual reality haptic
effects of fasting on self efficacy

Conditions: Chronic Pain; Fibromyalgia; Rheumatoid Arthritis; Gout; Headache; Arthritis; Gastrointestinal Diseases; Irritable Bowel Syndrome; Inflammatory Bowel Disease; Cardiovascular Diseases

Summary: the study aims to investigate * if a 7 day therapeutic fasting regimen will affect self-efficacy of patients with chronic diseases * the effects of fasting on physical and mental well-being, quality of life and body awareness/image * the association between patients characteristics and the perceived health benefit after fasting * the association between diagnosis according to traditional chinese medicine and physical and mental well-being during the course of fasting * experiences and perceptions of patients during fasting therapy

see above

Eligibility criteria:
inclusion criteria: * 18 years or older * eligible for fasting, i.e. normal weight (no anorexia, no nutritional deficiency, no bmi\ 35, no eating disorder) exclusion criteria: * psychiatric disorder * type 1 diabetes * hepatitis * severe somatic disorder (oncological disease, hepatological or nephrological) * pregnancy