Kornimate/medical-research-clean huggingface dataset:
continuous glucose monitoring for hyperglycemia in critically ill patients

Conditions: Hyperglycemia; Hypoglycemia; Critical Illness; Diabetes Mellitus

Summary: the investigators intend to conduct a single-center, prospective, randomized comparative trial of patients admitted to the intensive care unit (icu) who received continuous glucose monitoring (cgm) vs point of care (poc) glucose monitoring. the study will examine relevant outcomes for patients in the icu with diabetes mellitus and/or hyperglycemia. the primary outcome of the study will be the proportion of time in target range (blood glucose 70-180 mg/dl).

study purpose: the purpose of this study is to compare the use of continuous glucose monitoring (cgm) versus point of care (poc) glucose monitoring in the intensive care unit (icu) setting for differences in glycemic control and other important outcomes. research plan: this will be a prospective, single-center, randomized comparative trial of adult patients at north florida/south georgia veterans health system anticipated to be admitted to an icu for a minimum of 48 hours after enrollment. study participants will be randomly assigned to one of the study groups (cgm or poc) after being found eligible for inclusion and giving consent to participate. the cgm group will receive glycemic management based on cgm readings. the poc group will receive glycemic management based on poc glucose readings. study outcomes: groups will be compared for differences in clinical and safety outcomes. the primary outcome will be the proportion of time in target range (bg 70-180mg/dl). secondary outcomes will include mean glucose, hypoglycemia, hyperglycemia, icu length of stay, mortality, glucose variability, cost, and patient satisfaction. safety outcomes will include new infection, acute kidney injury, delirium, agitation, and pain. analysis methods: descriptive statistics and inferential statistical methods will be used as appropriate to report findings of this study.

Eligibility criteria:
inclusion criteria: * patients age 18-89 * past medical history of any diabetes mellitus or patients with at least 1 measured bg of 180 being treated with insulin (subcutaneous or infusion) * enrollment will occur within 72 hours after being admitted to an icu if history of diabetes * enrollment will occur within 72 hours after developing hyperglycemia in icu if no diabetes exclusion criteria: * pregnant patients * patients using cgms in the outpatient setting * diagnosis of diabetic ketoacidosis (dka) * diagnosis of hyperosmolar hyperglycemic state (hhs) * anticipated to require prone positioning while on insulin therapy * any contraindications to cgms based on manufacturer labeling * bg above maximum reading for cgm (e.g. greater than 400 mg/dl) * receiving medication that could interfere with cgm readings (based on manufacturer specifications) * receiving any dose of hydroxyurea as this could falsely elevate the sensor readings (if applicable for specific cgm) * receiving greater than 1,000mg acetaminophen every 6 hours in any form as this could falsely elevate the sensor readings (if applicable for specific cgm)
st. barbara specialised regional hospital no. 5: surveillance of healthcare-associated infections

Conditions: Surgical Site Infections

Summary: retrospective laboratory-based data collection study of surgical site infections: surveillance of healthcare-associated infections in orthopaedic and trauma surgery unit in sosnowiec, poland;


Eligibility criteria:
inclusion criteria: * patient being treated in the department and clinic of orthopaedic and trauma surgery, st. barbara specialised regional hospital no. 5, sosnowiec * patients undergoing surgery in studied unit exclusion criteria: * under 18 years of age * surgery of a different type than orthopedics * non-surgical treatment
exercise, rest breaks and ergonomics modification on fatigue and msk discomfort in static workstation

Conditions: Musculoskeletal Pain

Summary: the current study examines the effects of exercise, ergonomic modifications, and rest breaks on fatigue and musculoskeletal discomfort during computer tasks. for the purpose of this project, musculoskeletal discomfort is defined as a constellation of signs and symptoms that include muscle tension, paresthesia, pain, and/or physical strain in soft tissues and bones.

static workstation workers frequently experience musculoskeletal discomfort which, according to a survey of the literature, may include muscle tension, muscle fatigue, paresthesia, pain, and/or physical strain in soft tissues and bones. the incidence of musculoskeletal discomfort in office workers like computer users is as high as 50%. in various studies on static workstation workers, musculoskeletal discomfort has been reported, either separately or in aggregate, in the neck, shoulders, elbows, wrists, hands, back, legs, buttocks, ankles, feet, and chest. the current study examines the effects of exercise, ergonomic modifications, and rest breaks on fatigue and musculoskeletal discomfort during computer tasks. for the purpose of this project, musculoskeletal discomfort is defined as a constellation of signs and symptoms that include muscle tension, paresthesia, pain, and/or physical strain in soft tissues and bones.

Eligibility criteria:
inclusion criteria: * both male and female * age: 25-45 years * those static workstation office workers using a computer for at least 6 hours per day. * static workstation office workers screened by rosa. exclusion criteria: * discomfort from non-musculoskeletal origin * recent history of trauma and receiving any kind of treatment for the current condition * severe orthopedic disease * any mental and physiological illness that could interfere in the exercise

Keywords: pain workstation musculoskeletal rest break
tap block alone versus tapblock with rectus sheath block in liposuction surgery

Conditions: Pain

Summary: the transversus abdominis plane (tap) block is an effective regional nerve block for the anterior abdominal wall. an anesthesiologist typically administers the tap block preoperatively with ultrasound guidance. it is not yet commonly used during anterior abdominal wall liposuction, where postprocedural pain remains a major concern for patients and surgeons.

the author investigated the feasibility of administering the tap block under direct vision and compared postoperative narcotic use in patients who received analgesia by tap block vs with tap block i addition to rectus sheath block, both performed under direct vision during anterior abdominal wall liposuction.

Eligibility criteria:
inclusion criteria: * asa i-ii, consent, exclusion criteria: * allergy, coagulopathy, refusal, mentally unstable
study to evaluate the efficacy of rituximab in combination with low-dose radiotherapy in patients with relapsed non-hodgkin's lymphoma

Conditions: Non-Hodgkin's Lymphoma

Summary: this study aims to assess the short term efficacy of a combination of rituximab and low-dose radiotherapy in patients with non-hodgkin's lymphoma.

rituximab and low-dose total-nodal irradiation both have shown promising activity in patients with nhl. moreover, the radiolabelled antibody zevalin has been approved for the treatment of relapsed nhl. the patients in this study have a poor prognosis. the treatment strategy aims to control the disease and to ameliorate disease related symptoms with minimal toxicity. both, rituximab and low-dose radiotherapy are associated with minor toxicity if applied alone. the primary objective of the study is therefore to assess the short term efficacy of a combination of rituximab and low-dose radiotherapy in patients with non-hodgkin's lymphoma.

Eligibility criteria:
inclusion criteria: * b-cell non-hodgkin's lymphoma * at least one prior antitumor therapy * ecog performance status 0-2 * no major organ dysfunction * written informed consent exclusion criteria: * the following histologies are excluded: burkitt's lymphoma, mantle-cell lymphoma, primary cns-lymphoma, hiv-associated lymphoma

Keywords: nhl lymphoma radiotherapy rituximab palliative treatment
ellipsys fistula for hemodialysis access

Conditions: ESRD

Summary: to report the outcomes of patients having percutaneous proximal radial artery fistula creation.

the study would like to enroll up to 100 patients without age, gender-based, race and ethnicity enrollment restrictions for adults over 18 years of age. women of child bearing potential are not excluded. if a pregnant patient required, an arteriovenous fistula for hemodialysis an ellipsys® fistula would be an option. the investigator would like to consent previous ellipsys® patients with appropriate medical records so that the investigator may capture participants data for outcomes reporting.

Eligibility criteria:
inclusion criteria: * patient age \> 18 years or older * diagnosed with esrd or chronic kidney disease requiring dialysis or anticipating start of dialysis * adjacent vein diameter of \> 2.0 mm at target anastomosis site and confirmed clinically significant outflow * arterial lumen diameter of \> 2.0 mm at target anastomosis site * adequate collateral arterial perfusion: barbeau test grade a through c * radial artery -adjacent vein proximity \< 1.5 mm measured lumen edge-to-lumen edge via ultrasound exclusion criteria: * target vessel that are \< 2mm is diameter * distance between the target artery and vein \> 1.5 mm * edema of the upper extremity on the ipsilateral side * barbeau test grade d
bergen oral respiratory intervention study

Conditions: Periodontitis; Airway Obstruction; Lung Inflammation

Summary: the purpose of this study is to investigate if treatment of periodontitis (gum disease) in a relatively young and healthy population can improve lung function. it is hypothesized that removing the dental biofilm reduce the source of inflammatory bacteria that can reach the lungs, and thereby reduce lung inflammation and lead to improved lung function.

after being informed about the study and potential risks, all participants giving written informed consent will undergo a clinical screening to determine eligibility for study entry. the study participants will be randomized into two groups. half of the study participants will after baseline move directly into an active periodontal treatment phase including oral hygiene instructions and professional tooth cleaning by a full mouth disinfection protocol (intervention 2). new data will be collected after 6-8 weeks of healing. the second study group will after baseline receive prophylactic periodontal treatment by oral hygiene instructions and supragingival plaque removal (intervention 1). new data will be collected after 3-4 weeks. this group will now receive the active periodontal treatment phase (intervention 2) like the first study had initially. new data will be collected after 6-8 weeks of healing. both groups will receive supportive periodontal treatment every 3 months in 12 months after intervention 2.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of periodontitis (stadium i or ii) * measures of periodontal infection (pi) \> 50% * inflammation (bleeding index/bleeding on probing) \> 50% * never-smoker exclusion criteria: * asthma * symptoms of pollen allergy * chronic lung diseases * daily medication use which may interfere with the evaluation of the subject * pregnancy * use of systemic antibiotics last six months * subgingival scaling last six months * regularly use of oral antiseptic mouth rinse * use of snus (moist/smokeless tobacco) * current medical condition which may interfere with the evaluation of the subject

Keywords: periodontitis oral health lung function respiratory health periodontal treatment microbiome oral hygiene
interest of continuous non-steroidal anti-inflammatory drug treatment in ankylosing spondylitis patients treated by anti-tnf therapy in the prevention of radiographic outcomes

Conditions: Ankylosing Spondylitis

Summary: ankylosing spondylitis (as) is a frequent chronic inflammatory rheumatic disease that affects the axial skeleton, starting in the sacroiliac joints and spreading to the spine in most patients. non-steroidal anti-inflammatory drugs (nsaids) are the primary treatment for as. even if the use of anti-tnf agents has demonstrated good clinical efficacy in controlling inflammation, in contrast to other conditions such as rheumatoid arthritis and psoriatic arthritis, anti-tnf treatment has failed to demonstrate any benefit on the structural progression of as, some data even suggesting that it may accelerate the formation of syndesmophytes that seems to be an independent process of tnf. conversely, nsaids inhibit ossification phenomena independently of their anti-inflammatory properties, owing to a specific action on bone formation via prostaglandin inhibition. several features suggest that a continuous nsaid therapy is needed, in addition to anti-tnf treatment, to prevent syndesmophyte formation in as patients.


Eligibility criteria:
inclusion criteria: * patients aged over 18 years old * patients who fulfil 1984 modified new york criteria for ankylosing spondylitis: * sa patients with indications for anti-tnf treatment initiation according to the french society of rheumatology guidelines. * being affiliated to a health insurance system * having signed an informed consent form (later than the day of inclusion and before any examination required by the research) exclusion criteria: * patients who present another chronic systemic inflammatory disorder, different from ankylosing spondylitis. * patients who present contraindications to treatment with nsaids. * patient with daily corticosteroid treatment at a dosage ≥ 10 mg/day * pregnant or breastfeeding women * contra-indication to mri (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing to undergo mri * women that refuse to an effective contraception method for all the study duration

Keywords: nsaids anti-tnf syndesmophytes msasss
pilot study of maintenance therapy with intravenous amantadine

Conditions: Parkinson Disease

Summary: this is a pilot study for maintenance intravenous treatment with amantadine in patient with parkinson's disease who are not well balanced with medical treatment.


Eligibility criteria:
inclusion criteria: * patients with idiopathic parkinson disease * age\<80 * patients with no motor improvement under optimal treatment with anti parkinson medications * patients with moderate to severe dyskinesias * patients with pd with side effects who can not tolerate anti parkinson medications exclusion criteria: * age\>80 * patients with parkinson syndromes, vascular parkinsonism or drug-induced parkinsonism * patients with pd who developed adverse reactions to oral amantadine * contraindication of amantadine treatment

Keywords: amantadine parkinson disease dyskinesia
mri and ct in gastroesophageal junction or upper gastric adenocarcinoma

Conditions: Gastric Cancer, Gastroesophageal Junction Cancer

Summary: accurate preoperative siewert classification, precise assessment of the extent of esophageal involvement, and staging is crucial for determining the appropriate surgical approach and achieving negative resection margins. the purpose of this study is to investigate the diagnostic performance of the multi-parametric magnetic resonance imaging (mpmri) and computed tomography (ct) in gastroesophageal junction and upper gastric cancers.

despite a continuous decline in the incidence of gastric cancer in recent years, the morbidity and mortality rates associated with the gastroesophageal junction and upper gastric cancers remain elevated. consequently, it is imperative to develop more refined and individualized precision strategies for screening, diagnosis, surgical intervention, and comprehensive treatment. due to the unique anatomical location, considerable debate exists regarding the critical aspects of its surgical management in clinical practice. multiparametric mri offers significant anatomical benefits due to its high soft tissue resolution, and its functional imaging capabilities present promising applications. with advancements in abdominal imaging technology, novel techniques such as high-order diffusion imaging and compressed sensing technology have facilitated high-resolution mri of the stomach during free breathing, which is now implemented in clinical practice. prior research has demonstrated that individualized gastric mri scanning consistently yields superior image quality, and mri provides greater accuracy than ct in preoperative staging assessments. nonetheless, the comparative study of mri and ct in patients with gastroesophageal junction and upper gastric cancers remains to be elucidated.

Eligibility criteria:
inclusion criteria: 1. patients with gastric cancer confirmed by preoperative gastroscopic biopsy; 2. underwent standardized mpmri and ct examination; 3. patients with complete postoperative pathological data and pathological results of gastroesophageal junction or upper gastric adenocarcinoma; exclusion criteria: 1. combined with other tumors; 2. clinical and imaging data were missing or could not meet the research needs; 3. the location of lesions could not be determined;

Keywords: mr ct adenocarcinoma of the gastroesophageal junction gastric cancer
synergic effects of physical activity and probiotic on gut immune system and quality of life of breast cancer survivors.

Conditions: Breast Cancer Females

Summary: physical exercise along with gut microbiota improvement -because of probiotic intake- can improve the quality of life and immune system in breast cancer survivors. this is achieved because exercise improves the muscle mass in cancer patients (often reduced by treatment and/or inactivity), together with the gut microbiota improvement, this stimulates the inmune system function, improving the quality of life of these patients.

the aim of this study is to determine the effects of physical exercise together with the supplementation of a probiotic on gut microbiota balance, the gut immune system and quality of life (intended as functional and muscular capacity, physical qualities and emotional state) in breast cancer survivors . a randomized controlled pilot study has been designed in three parallel groups. breast cancer survivors will be randomly assigned to each of the 3 groups: a) probiotic supplementation + supervised combined physical exercise (pef), b) probiotic supplementation and habitual sedentary lifestyle (p), and c) control group will follow their usual lifestyle and will receive a placebo (c). the exercise intervention will last 12 weeks. it will include three weekly sessions of programmed physical exercise of \~ 60 min duration (combined training). the exercise program will be individualized and will follow the rules of the world reference institutions for aerobic training. each session will be held in a qualified fitness center and it will be supervised and individualized for each subject by professional experts .the two supplemented groups will take 3 capsules (lactobacillus rhamnosus, lactobacillus paracasei, lactobacillus acidophilus, bifidobacterium bifidum) a day (at night before bedtime) for 12 weeks. the variables gut microbiota, fecal levels of immunoglobulin a, cardiorespiratory capacity, anthropometry variables, lifestyle, muscular capacity, quality of life, anxiety, depression and stress levels will be analized at the beginning (baseline dose) and after 12 weeks of intervention.

Eligibility criteria:
inclusion criteria: * breast cancer survivors * \<18 aged. * no chemotherapy treatment or that at least three months have passed after the last chemotherapy treatment before the beginning of the study. * breast cancer status: i-iv status. * ecog scale: 0-1. * normal weight. exclusion criteria: * extreme diet. * exercise practice (at least at the doses recommended by who) * presence of heart disease * uncontrolled blood hypertension: (\>160/90 mmhg). * uncontrolled metabolic disease * infectious chronic disease * uncontrolled pain * pregnancy or breast feeding * gastrointestinal disease * alcoholism * any condition that contraindicates the exercise practice in survivors cancer (fractures risk, severe leukopenia , low platelet count) * antibiotics intake during the study.

Keywords: breast cancer survivor probiotic immune system physical exercise quality of life gut microbiota
(withdrawal) mechanism of transjugular intrahepatic portosystemic shunt to improve sarcopenia

Conditions: Sarcopenia; Mechanism; Cirrhosis

Summary: sarcopenia is particularly common in patients with chronic liver disease, especially in patients with decompensated cirrhosis, where the prevalence can be more than 50%. sarcopenia is an important risk factor for a significant increase in mortality in cirrhotic patients, and is closely associated with a high incidence of complications such as hepatic encephalopathy, ascites, and infections . recent studies have found that tips not only significantly improves clinical symptoms caused by portal hypertension, but may also have a positive effect on skeletal muscle mass and function in patients. although the effect of tips in improving sarcopenia has been preliminarily confirmed, its mechanism is not yet fully understood. therefore, there is an urgent need to explore the mechanism of action of tips to improve sarcopenia and provide guidance for clinical treatment options.

according to whether the sarcopenia improved or not in patients after tips, patients were divided into sarcopenia group and non-sarcopenia group, and the relationship between fgf21 levels and sarcopenia improvement in patients after tips was analyzed by analyzing the differences between the two groups. during the follow-up of patients after tips, blood samples were collected to test serum fgf21 levels and imaging examinations were performed to assess the improvement of sarcopenia; changes in nutritional status, muscle strength and function indicators were analyzed in the process of sarcopenia improvement; changes in serological indicators were analyzed in the process of sarcopenia improvement, with a focus on the serum fgf21 level; the combination of the serum fgf21 level and the muscle strength and function indicators, and evaluate their value in the prognosis of tips.

Eligibility criteria:
inclusion criteria: 1. diagnosed with liver cirrhosis and needing tips surgical treatment; 2. aged between 18-75 years old; 3. able to understand and sign the informed consent form and willing to cooperate in completing the examinations and follow-up visits. exclusion criteria: 1. combination of serious cardiovascular and cerebrovascular diseases (such as acute myocardial infarction, severe heart failure, etc.); 2. suffering from malignant tumors and in the active stage; 3. recent (within 3 months) history of major surgeries or traumas; 4. the presence of mental illness or cognitive disorders, which are unable to cooperate with the study; 5. undergoing other special treatments that may affect the results of the study (such as certain specific immune-suppressing agents, hormones, etc.)

Keywords: sarcopenia cirrhosis fgf21