Kornimate/medical-research-clean huggingface dataset:
oxytocin, alcohol craving, and intimate partner aggression

Conditions: Alcohol Use

Summary: alcohol use disorders (aud) and intimate partner aggression (ipa) frequently co-occur. there are significant health and economic burdens associated with aud and co-occurring ipa, and little empirical data to guide treatment efforts. the neuropeptide oxytocin may help mitigate both aud and ipa. however, clinical data examining oxytocin's effects on human aggression is scant. the proposed study is designed to address these gaps in the literature by utilizing a human laboratory paradigm to test the effects of oxytocin on craving and aggression among couples with aud and co-occurring ipa.


Eligibility criteria:
inclusion criteria: * inclusion criteria indicate that participants must * aged 18 or over * fluent in english * endorse at least one instance of mild or moderate physical ipa with their partner in the past 6 months as defined by the revised conflict tactics scale (cts-2) * both partners must be willing to participate * one or both partners must meet diagnostic and statistical manual of mental disorders (dsm-v) criteria for an alcohol use disorder (aud). concurrent substance use disorders (e.g., marijuana) is acceptable provided alcohol is the participant's primary substance of choice. exclusion criteria: * exclusion criteria include * pregnancy or breastfeeding * current or history of psychiatric or medical condition that could interfere with neuroendocrine function (e.g., hematological, endocrine, renal, or pulmonary disease; synthetic glucocorticoid or exogenous steroid therapy; psychotic, bipolar, eating disorders) * body max index (bmi) ≥ 39 * current suicidal ideation and intent * severe physical or sexual ipa in the past six months as defined by the conflict tactics scale (cts-2) * initiation of psychotropic medication in the past 4 weeks * acute alcohol withdrawal as indicated by a score of 8 or greater on the clinical institute withdrawal assessment of alcohol scale (ciwa-ar).

Keywords: couples oxytocin aggression alcohol
intraosseous vs intravenous access for cardiac arrest treatment

Conditions: Cardiac Arrest

Summary: in patients with out-of-hospital cardiac arrest in singapore, investigators aim to assess the benefit of introducing a resuscitation protocol including the use of intravenous (iv) access and/or intraosseous (io) vascular access in the pre-hospital setting. the assumption is that low vascular access rates could be due to difficulty of setting iv cannulas in the field due to certain factors like poor lighting or space constraints. thus, by introducing a protocol including io access for difficult iv cases, success rates for vascular access will be higher and this might lead to higher survival rates. this will be a study comparing 'iv+io' and 'iv alone' protocols in patients with cardiac arrest managed by singapore civil defence force (scdf) emergency ambulance service. the trial will recruit 400 patients over 1 year. each of the 30 scdf ambulances will provide both 'iv+io' and 'iv alone' treatments in 2 consecutive phases of 6-months in order to allow for all ambulance crew a chance to be trained on usage of io. currently, io insertion is the accepted standard of care in singapore general hospital, department of emergency medicine.

primary objectives: in adult and paediatric patients with out-of-hospital cardiac arrest (ohca) in singapore, investigators aim to evaluate the incremental benefit of introducing a resuscitation protocol including the use of intravenous (iv) access and/or intraosseous (io) vascular access compared to protocols with only intravenous (iv) access by scdf paramedics in the pre-hospital setting on the return of spontaneous circulation (rosc) rates. secondary objective: * to compare the success rates of vascular access with iv access and/or io insertion compared to that with intravenous (iv) access alone by scdf paramedics in the pre-hospital setting. * to compare the rates of successful 1st dose adrenaline given in the field to cardiac arrest patients in iv+io and iv groups and whether this translates into a higher survival rate at 30 days. * to determine the cost benefit of introducing io access to the emergency ambulance service for ohca. hypothesis: in adult and paediatric patients with out-of-hospital cardiac arrest (ohca) in singapore, the hypothesis is that low vascular access rates could be due to difficulty of setting iv cannulas in the field due to certain factors like poor lighting or space constraints. thus, by introducing a protocol including io access for difficult iv cases, success rates for vascular access will be higher and this might lead to a higher rosc and survival rates.

Eligibility criteria:
inclusion criteria: * cardiac arrest (medical or traumatic) * intravenous fluids or medications needed exclusion criteria: * adult needle (weight ≥ 40 kg) * paediatric needle (weight 3 - 39 kg)
more than just p-values: mcid for the vas, msq and femd in patients with primary dysmenorrhea

Conditions: Primary Dysmenorrhea; Pain; Menstrual Discomfort

Summary: the aim of this study is to determine the minimal clinically important difference (mcid) for the visual analog scale (vas), menstrual symptom questionnaire (msq), and functional and emotional measure of dysmenorrhea (femd) in patients with primary dysmenorrhea (pwpd).

100 pwpd will receive functional exercises three times a week for three menstrual cycles. patients will be assessed on the most painful days of the first (baseline), second, and third menstrual cycles. the receiver operating characteristics (roc) method and gamma coefficient analysis will be applied to determine the responsiveness.

Eligibility criteria:
inclusion criteria: * diagnosis of pd according to the "no. 345-primary dysmenorrhea consensus guideline", * pain level of three or more according to vas during activity (moderate to severe pain), * patients aged 18-35 years (when pd becomes more prevalent), * regular menstrual cycle with a duration of 28±7 days, * nulliparity. exclusion criteria: * historical background of chronic urogenital infections or drug use, * pregnancy, * secondary dysmenorrhoea caused by gynaecological conditions such as endometriosis, adenomyosis and uterine fibroids.

Keywords: dysmenorrhea menstruation visual analog scale minimal clinically important difference roc curve
dhf-20-1839-2: clinical performance study protocol for therascreen® kras rgq pcr kit

Conditions: Metastatic Colorectal Cancer (mCRC)

Summary: to utilize the therascreen kras rgq pcr kit, as a screening test in amgen's phase 3 clinical study protocol 20210081, in order to identify patients with mcrc kras g12c mutation positive tumors to be enrolled in the drug clinical trial. results of the phase 3 amgen study 20210081 will serve as the basis for establishing the clinical performance of the therascreen® kras rgq pcr kit as a companion diagnostic (cdx) for the identification of patients with metastatic colorectal cancer, who may benefit from treatment with sotorasib.

the proposed device clinical performance study and the medicinal clinical trial will be conducted simultaneously as a combined trial according to mdcg 2022-10. the clinical trial 20210081 is a randomized, open-label, active-controlled study of sotorasib, panitumumab and folfiri versus folfiri with or without bevacizumab-awwb for treatment-naïve subjects with metastatic colorectal cancer with kras p.g12c mutation (codebreak 301). it is estimated that approximately 450 patients from 31 countries will be enroled based on the presence of tumor kras g12c mutation, detected using therascreen kras rgq pcr kit, along with other clinical trial inclusion criteria, into the phase iii clinical trial. results from the phase 3 amgen study 20210081 will be used to evaluate the clinical performance of therascreen® kras rgq pcr kit as a cdx device for identification of patients with mcrc who may benefit from treatment with sotorasib in treatment-naïve patients with metastatic colorectal cancer.

Eligibility criteria:
inclusion criteria: * subjects who consent to participate in the eligibility screen for protocol 20210081 will have their tumor tissue tested for the presence of kras g12c mutation under the proposed performance study. exclusion criteria: * there is no separate inclusion and exclusion criteria for the performance study.

Keywords: metastatic colorectal cancer therascreen kras g12c sotorasib clinical performance study companion diagnostic
study of vx-985 in subjects with chronic hepatitis c

Conditions: Chronic Hepatitis C

Summary: the purpose of this study it to evaluate the safety and tolerability of vx-985 in hcv subjects. this study will also evaluate the antiviral activity and pharmacokinetic profile of vx-985.


Eligibility criteria:
inclusion criteria: * subjects who are male or females of non-childbearing potential aged 18 to 64 years(inclusive) with a body mass index (bmi) between 18 and 32 (kg/m2) * certain subjects must agree to use acceptable contraceptive methods as specified in protocol * subjects who are treatment naïve and are infected with genotype 1 chronic hepatitis c * subjects must be in good health and have normal laboratory values as judged by investigator * subjects must not have clinically significant abnormal results for physical examination exclusion criteria: * subjects must not have received approved or experimental hcv therapy * subjects must not have evidence of hepatic decompensation: history of ascites, hepatic encephalopathy, or bleeding esophageal varices * subjects must not have any known history of other cause of significant liver disease including hepatitis b, drug or alcohol-related cirrhosis, etc * subjects must not be diagnosed with or have suspected hepatocellular carcinoma * subjects must not have histologic evidence of hepatic cirrhosis on any liver biopsy or test capable of detecting cirrhosis within the past 2 years * subjects with a known history or other evidence of severe retinopathy or clinically significant ophthalmological disorder * subjects must not have a history of any illness that might confound the results of the study or pose an additional risk in administering study drug(s) to the subject e.g. history of cardiovascular or central nervous system disease, ongoing psychiatric disorder, poorly controlled diabetes, etc * subject must not have taken any of the prohibited medications within the specified time before study start or take certain medications (including herbal supplements) during the study * subjects must not have a history of drug or alcohol abuse or addiction within 6 months before the start of dosing, or test positive for alcohol or drugs of abuse * subjects must not have donated or had a significant loss of blood within 56 days of the start of dosing, or donated more than 1 unit of plasma within 7 days before the start of dosing * subjects must not consume excessive amounts of caffeine * subjects must not have participated in a clinical study involving administration of either an investigational or a marketed drug within 2 months * subjects who are female and have a positive pregnancy test and/or who are considered to be of childbearing potential or are nursing. * subjects that have a female partner who is pregnant, nursing, or planning to become pregnant during the study or shortly after the study
implementation of brief dynamic interpersonal therapy at the va

Conditions: Depression; Anxiety

Summary: the goal of the proposed project is to collect data from clinician files and the electronic medical record to describe the clinical implementation of brief dynamic interpersonal therapy (dit), an individual psychotherapy for depression and anxiety, at the va through psychology staff and trainees between 2012-present.

the goal of the proposed project is to collect data from clinician files and the electronic medical record to describe the clinical implementation of brief dynamic interpersonal therapy (dit), an individual psychotherapy for depression and anxiety, at the va through psychology staff and trainees between 2012-present. the study will collect data on patient characteristics (e.g. demographics, diagnoses, reasons for referral, etc.), attendance, and treatment outcome of depression, anxiety and psychosocial functioning to evaluate and describe the feasibility of implementing dit at the va. medical records of veterans who were provided with dit treatment between 2012-present will be reviewed and data on patient characteristics (which will include demographic information, diagnoses, reasons for referral, etc.), treatment compliance, and treatment outcome as measured by changes in depression, anxiety, and psychosocial functioning during the treatment period and up to the present will be collected. the investigators estimate that approximately 100 veterans have been offered and/or provided dit since 2012 by psychology trainees and staff. this study will provide preliminary data on the feasibility of implementing dit treatment at the va. the first trial of dit for mdd in the vha is currently being conducted by the pi and the information from the retrospective chart review would help to provide additional data as part of a proposal for a larger scale rct of dit.

Eligibility criteria:
inclusion criteria: - receive dit treatment at vanyhhs between 2012-present exclusion criteria: - was not referred for, or did not receive at least 1 dit session at vanyhhs between 2012-present

Keywords: veterans depression anxiety psychodynamic psychotherapy treatment
new reference values for intracranial pressure

Conditions: Intracranial Pressure

Summary: intracranial pressure is a cornerstone in neurosurgical care used in a variety of diseases. however currently, doubts regarding normal intracranial pressure exist. few studies have investigated normal intracranial pressure in truly normal adults. the aim of this study is to investigate intracranial pressure in adults who have normal intracranial pressure physiology. in this prospective, multicenter, clinical study, the intracranial pressure of 10 adults requiring surgery for an unruptured aneurysm will be investigated. these patients are thought to be normal in terms of intracranial pressure physiology. at the end of their surgery for an aneurysm, a telemetric intracranial pressure monitoring sensor will be implanted. afterward, intracranial pressure curves will be obtained non-invasively 1., 14., 30 and 90 days after implantation. the intracranial pressure will be investigated in 5 different positions (supine, lumbar, upright sitting, standing and walking). furthermore, a 24-hour measurement will be performed in their home environment, thus investigating intracranial pressure under daily activities.


Eligibility criteria:
inclusion criteria: * above the age of 18 * requiring surgery for a "cold" (unruptured) aneurysm exclusion criteria: * current or previous examination or treatment for hydrocephalus * current or previous examination or treatment for idiopathic intracranial hypertension * previous operation with insertion of cerebrospinal fluid shunt * previous trauma with intracranial hemorrhage * global cerebral edema * increased infection risks * surgical complications during the primary operation * unable to understand patient information

Keywords: intracranial pressure icp normal value reference value hydrocephalus
interaction between gut microbiota and tkis in defining the clinical outcomes of patients with cml

Conditions: Leukemia,Myeloid, Chronic

Summary: gut microbiome (gm) is acquiring increasing importance in human health and disease. gm influences hematopoiesis and immune cells types differentiation. patients with cancer are characterized by dysbiosis and compromised immunity. in the case of chronic myeloid leukemia (cml), treatment with tyrosine kinase inhibitors (tkis) restores immunosurveillance; in particular deep molecular response (dmr) is associated with increased levels of nk and cd8+ tcells. there is no literature on the effects of gm on cml outcomes. this project aims to identify a microbial signature associated with a higher probability of achieving dmr.

philadelphia positive chronic myeloid leukemia (cml) is a myeloproliferative disorder originating from pluripotent hematopoietic cells. treatment typically involves tyrosine-kinase inhibitors (tkis), which have significantly improved long-term survival. while generally well-tolerated, tkis can cause side effects, particularly gastrointestinal issues (diarrhea, constipation, abdominal pain, malabsorption, bleeding) and liver/pancreatic enzyme increases, which may persist and affect quality of life. additionally, cardiovascular events, often linked to metabolic changes (e.g., glucose intolerance, diabetes, hypertension), occur more frequently during treatment. these side effects raise concerns about tkis potentially inducing a chronic inflammatory response. recent research on the human microbiota highlights its importance in health. the microbiota plays a critical role in gut health, immune function, and metabolic processes, and its imbalances (dysbiosis) can contribute to a range of diseases. factors such as diet, age, physical activity, and medication use can disrupt the microbiota. however, the relationship between gut microbiota and tkis in cml patients remains unexplored. the current study will evaluate by whether different cml gut microbiota genotypes influence tki treatment responses, whether microbiota alterations cause inflammation or metabolic disorders, and whether microbiota, along with dysmetabolism and dysimmunity, contribute to variations in treatment efficacy and tolerance

Eligibility criteria:
inclusion criteria: * age \> 18 years old * chronic myeloid leukemia patients * any stage of the disease exclusioni criteria: none

Keywords: chronic myeloid leukemia gut microbiota tyrosine kinase inhibitors
questionnaire of lower urinary tract symptoms among women before and after surgical correction of uterine prolapse

Conditions: Pelvic Organ Prolapse

Summary: . the study will include patients who underwent pelvic reconstructive surgery for advanced pelvic organ prolapse (pop-q ≥ 3). data regarding preoperative evaluation, surgical procedure, and post-operative management will be collected. women will receive a follow up questionnaire. . the baseline questionnaire included data on age, urinary incontinence, daytime frequency, nocturia, postmicturition dribble, straining, urgency, incomplete bladder emptying, and hesitancy. women were asked about leakage caused by coughing or sneezing, moving, lifting, sleeping, sexual intercourse, urgency, and rest.

pelvic organs prolapse (pop) is defined as the downward descent of the pelvic organs resulting in protrusion of the vagina and/or uterine cervix. pop and overactive bladder (oab) often co-exist. the international continence society defines oab as "urgency with or without urge incontinence, usually with frequency and nocturia" of women with symptomatic pelvic organ prolapse, 13-39% experience voiding dysfunction (vd). the aim of the study is to determine the effect of prolapse surgery on voiding function. the study will include patients who underwent pelvic reconstructive surgery for advanced pelvic organ prolapse (pop-q ≥ 3). data regarding preoperative evaluation, surgical procedure, and post-operative management will be collected. women will receive a follow up questionnaire. non-responders will send a reminder after three weeks and if the non-responders still failed to respond were eventually asked to complete a short form comprising questions on urgency and incontinence. this procedure followed guidelines outlined by the local ethical committee. the baseline questionnaire included data on age, urinary incontinence, daytime frequency, nocturia, postmicturition dribble, straining, urgency, incomplete bladder emptying, and hesitancy. women were asked about leakage caused by coughing or sneezing, moving, lifting, sleeping, sexual intercourse, urgency, and rest. stress incontinence according to the international continence society defined as leakage caused by exertion (coughing or sneezing, moving, or lifting) and urge incontinence as leakage associated with urgency.

Eligibility criteria:
inclusion criteria: 1. age; greater than or equal to 18 years 2. women with urogenital prolapse grade 3 or more 3. indicated for surgical repair for pelvic organ prolapse 4. willing and able to sign an informed consent 5. willing to comply with the study protocol exclusion criteria: 1. anti-incontinence surgery 2. lower urinary tract anomaly 3. active urinary tract infections 4. bladder tumor. 5. bladder stones
effectiveness of asthma education program based on the roy adaptation model

Conditions: Asthma Patients

Summary: the aim of the study; to determine the effect of the education program given to individuals diagnosed with asthma based on roy's adjustment model on their psychosocial adjustment to the disease and their quality of life.

in addition to the expected physiological effects of asthma on individuals, the course of the disease and the course of the individual's life will change as the duration of living with the disease increases. in order to improve the attitude towards the disease positively in asthmatic individuals, to ensure asthma control and to improve the quality of life by managing the process well, patients' behaviors against the disease should be improved. regular repetition of trainings created within the framework of a specific plan to improve adaptation behaviors is one of the recommended steps to empower individuals with chronic diseases during the disease process. in this randomized controlled trial, individuals aged 18-64 years with a diagnosis of asthma, an asthma control test (act) score of 24-20 (partial control) or ≤19 (uncontrolled) and no secondary chronic disease other than asthma were included.

Eligibility criteria:
inclusion criteria: * being in the age range of 18-64 * diagnosed with asthma for at least 6 months * to live in the city center * asthma control test (act) score 24-20 (partial control) or ≤19 (uncontrolled) * patients who voluntarily agreed to participate in the study exclusion criteria: * has a secondary chronic disease other than asthma * diagnosed with neuropsychiatric illness * individuals with inability to understand or speak turkish and sensory problems that prevent communication

Keywords: asthma patient psychosocial adjustment life quality
pancreatic surgical database

Conditions: Pancreatic Neoplasms

Summary: this data base has been set in order to gather medical and surgical information from patients who have undergone surgery for pancreatic cancer, at institut paoli calmettes or assistance publique des hôpitaux de marseille, france.


Eligibility criteria:
inclusion criteria: * patient \>18 ans * surgery for a pancreatic cancer exclusion criteria: * patient refusal to participate in the study

Keywords: cata collection pancreatic cancer surgery