Kornimate/medical-research-clean huggingface dataset:
acceptability assessment of an optimized birthing position

Conditions: Birth; Prolonged

Summary: this qualitative study evaluates the acceptability of positioning pregnant women in labour in an optimized position, which consists in the hyperflexion of the legs and the loss of the lumbar lordosis. twenty patients in situation of dystocia will adopt the described position for a limited amount of time.

recent data brings out that the caesarian section rate in switzerland is quite high, reaching 33.4 %. though, the reasons to this increasing amount of cs are not fully known. therefore, it is absolutely necessary to expand the existing knowledge in different fields, including the biomechanics of childbirth. numerous cs are performed in response to an obstructed labour, especially when the foetus does not engage in the pelvis near full dilatation. in order to manage such situations, midwifes currently position parturients in pragmatic postures. although not verified by data, this care management suggests that it is possible to impact the position of the bone segments at stake for vaginal birth including pelvis and lumbar spine and to promote the descent of the foetus through the pelvic inlet plane. in his phd thesis about vaginal birth biomechanics, desseauve et al investigated this area and found out that an optimized position similar to the squatting position (hyperflexion of the thighs and loss of the lumbar lordosis) could be close to the perfect delivery position in terms of ability for the foetus to go through the pelvic inlet plane. although these findings are encouraging, it is yet to be confirmed in clinical practice, particularly when a dystocia occurs. prior to doing that, it is though necessary to validate the optimized posture in terms of acceptability in a qualitative clinical study. in this study, fifteen to twenty parturients who respond to the inclusion criteria and whose foetus does not engage in the pelvis near full dilation will be asked to adopt the optimized position for a twenty minutes period. the investigator will then consign information reflecting the progress of the labour on a data sheet.

Eligibility criteria:
inclusion criteria: * informed consent as documented by signature * parturient in situation of mechanical dystocia (non engagement at full dilation) exclusion criteria: * inability or medical contraindications to undergo the investigated intervention (e.g. orthopaedic injury or disease preventing the parturient from adopting the optimised position) * clinically significant concomitant diseases * incapacity of judgment * inability to follow the procedures of the study due to language problems, psychological disorders, dementia, etc. * foetus cardiac rhythm disorder

Keywords: birthing position dystocia
ct evaluation of cardiovascular risk markers in obese patients

Conditions: Epicardial Fat; Obesity; Cardiovascular Risks Markers; Metabolic Syndrome; Low Dose Computed Tomography

Summary: obesity is a chronic metabolic disorder : it leads to coronary heart disease and early atherosclerosis. coronary artery calcium measured by ct is known as a robust predictor to predict risk for cardiac events in symptomatic and asymptomatic individuals. furthermore, recent studies show that other ct risk factor exists, independent of calcium scoring, such as epicardial fat, intrathoracic fat and visceral fat. the aim of this prospective study is to evaluate these new cardiovascular risk markers in obese patients, using standard dose ct and low dose ct with adaptative statistical iterative reconstruction.

in this prospective single-center study, obese patients of our clinical nutrition service, hospitalized for nutritional assessement, are included. all unenhanced coroct examinations are performed on the same 64-row ct scanner (discovery ct 750 hd scanner, ge healthcare), using prospective ecg-triggerring. the investigation protocol began with a standard-dose acquisition followed immediately by a low-dose acquisition, recorded over strictly identical segments (identical first and last sections). after these two examinations, estimated dose values are less than the diagnostic scan reference level for a coroct.

Eligibility criteria:
inclusion criteria: * obesity \>30 indicated non enhanced coroct for calcium scoring. exclusion criteria: * \<18 ans * low framingham scoring * pregnancy * not providing informed consent * history of cardiovascular disease.

Keywords: epicardial fat obesity cardiovascular risks markers metabolic syndrome low dose computed tomography
descriptive, prospective, non-interventional study (nis) to describe mirena and amenorrhea related acceptability in contraception indication in medical practice

Conditions: Female Contraception

Summary: marilia is a prospective, non-interventional, multicenter study. the purpose of this study is to describe the acceptability of amenorrhea in contraception indication of mirena users during one year follow up in medical practice. 500 patients in 20 centers will be enrolled in the study. bleeding profile, removal or non-removal of the ius (intrauterine system) will be evaluated.


Eligibility criteria:
inclusion criteria: * age 19-40 years at the time of mirena iud insertion * using mirena only for contraception indication * never having used the product before * no heavy menstrual bleeding diagnosed * have signed informed consent to participate in this study exclusion criteria: * nulliparous * pregnancy * mirena's contre-indication * mirena for hmb * abnormal bleeding pattern

Keywords: mirena contraception amenorrhea
effects of exenatide on glycemic control and weight in continuous subcutaneous insulin infusion (csii) type 2 treated patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to determine whether exenatide is effective to improve glycemic control among type 2 diabetic patients treated by insulin pump therapy.


Eligibility criteria:
inclusion criteria: * men or women aged 35 to 70 * type 2 diabetes diagnosed for at least 12 months, according the criteria of the american diabetes association : * presence of classic symptoms of diabetes mellitus with unequivocal elevation of plasma glucose (2-hour post-prandial or random glucose \>200 mg/dl) or * fasting plasma glucose elevation on more than 1 occasion \> 125 mg/dl or * patient currently undergoing pharmacological and/or non-pharmacological treatment for diabetes mellitus * csii treatment using a rapid analog for at least 6 month (csii being initiated in patients with hba1c \> 8 % despite a well-conducted mdi trial using a 2 to 5 daily injection regimen) * hba1c ≥ 7,5% and ≤ 10 % * bmi ≥ 25 and ≤ 45 * stable body weight (≤10% variation) during the 3 last months exclusion criteria: * type 1 diabetes assessed by positive anti-gad65 or anti-insulin or anti-ia2 antibodies * monogenic diabetes (mody, mitochondrial diabetes...) * current treatment with oha (oha ought to be interrupted at least two months prior to inclusion in the study) * current treatment specifically addressed for weight lost (orlistat, sibutramine, rimonabant may be interrupted at least 3 months prior to inclusion in the study) * use of corticosteroid therapy for more than 10 days within the 3-past months, or patient who ought to be treated by corticosteroid during the study period * clinically significant hepatic disease * documented gastroparesis, or current use of drugs that directly affect gastrointestinal motility, or any significant abdominal disease that may increase the risk of adverse gastrointestinal effects induced by exenatide * kidney failure (mdrd less than 50 ml/min) * pregnancy/breastfeeding * any social and/or mental condition rendering the subject unable to understand the scope and possible consequences of the study * concurrent enrolment in another clinical trial * geographically inaccessible for follow-up visits required by protocol

Keywords: type 2 diabetes csii exenatide double blind placebo controlled study
acupuncture compared with "sham" acupuncture for treatment of chronic neck myofascial pain

Conditions: Chronic Neck Myofascial Pain Syndrome

Summary: in order to investigate the therapeutic effect of acupuncture on chronic neck myofacial pain syndrome, the investigaotrs designed a pilot study of a single-blind randomized controlled trial. a total of 34 chronic neck myofacial pain syndrome patients were selected from department of neurology of nantou hospital, department of health. the age ranged from 18 to 85, and all subjects were full informed consent and volunteers. they were divided into two groups of 17 subjects randomly as follows: acupuncture group, acupuncture stainless needles were inserted into bilateral fenhchi, jianliao and houxi acupoints, respectively. the acupuncture needles then were manual twist and de qi, and remain for 20 min; sham acupuncture group, the methods were identical the acupuncture group, but acupuncture stainless needles were inserted into subcutaneous tissue only. all the subjects were treated with acupuncture two times per week and continuously three weeks, i.e. six times acupuncture treatment. the therapeutic effect of acupuncture was assessed before and finishing six times acupuncture treatment, and four weeks and twelve weeks after stopping acupuncture, respectively. the index of acupuncture therapeutic effect was according to the range of motion (rom) of the cervical spine, the intensity of pain (short-form mcgill pain questionnaire; sf-mpq) and quality of life (sf-36). the investigators expect acupuncture apply to bilateral fenhchi, jianliao and houxi acupoints may relief the pain and motion of chronic neck facial pain syndrome patient, and also improves the life quality.


Eligibility criteria:
inclusion criteria: * 18-85 year-old patients with neck myofascial pain for more than one month; not received any treatment in the two weeks before participating this study exclusion criteria: * fracture or surgery of the cervical spine; cervical radiculopathy or myelopathy; any rheumatic disorder; systemic disorders; major psychiatric disorder, alcoholism or substance abuse; coagulation dysfunction, or related medicines; pregnancy; contraindications to acupuncture; refused to sign consent
discover the immune signature of sepsis caused by acute pulmonary infection: a cohort study

Conditions: Sepsis; Viral Pneumonia; Influenza; Upper Respiratory Tract Infection

Summary: the goal of this observational study is to describe the immune signature of acute pulmonary infection.the main questions it aims to answer are: 1. nasal mucosal immune response in patients with influenza infection 2. difference of immune response between viral sepsis and bacterial sepsis 3. immunological differences between viral sepsis and viral pneumonia

1. aging could influence host immune response. elderly people are more likely to progress to severe pneumonia than young people. nasal mucosa is the initial infection site of influenza infection. single cell sequencing of nasal mucosal cell that may provide valuable insights into host response to influenza infection. 2. sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. although bacteria are considered as the main pathgens of sepsis，sars-cov-2 or influenza infection also can cause multiple organ dysfunction which meet the definition of sepsis 3.0. viral sepsis has not received enough attention for a long time. it is important to understand the difference between viral sepsis and bacterial sepsis that may help to develop better strategies to diagnose and treat sepsis. 3. viral pneumonia is one of the leading infectious cause of death woldwide.pneumina is the most common cause of sepsis.the mechanism of viral pneumonia progressing to sepsis needs to be further investigated.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years at time of signing informed consent form 2. chest imaging confirmed pneumonia. 3. informed consent is obtained 4. the pneumonia onset ≤8 days exclusion criteria: 1. sao2/spo2≤94% on room air or pa02/fi02 ratio \<300mghg before the onset of pneumonia 2. severe liver disease (e.g. child pugh score ≥ c, ast\>5 times upper limit) 3. patients with known severe renal impairment (estimated glomerular filtration rate ≤30 ml/min/1.73 m2) or receiving continuous renal replacement therapy, hemodialysis,peritoneal dialysis） 4. pregnant or lactating women 5. patients were eligible for organ transplantation or had undergone previous organ transplantation surgery 6. hiv infection 7. had unstable angina or myocardial infarction within 30 days without vascular recanalization treatment
neural pressure support, synchrony and respiratory muscle unloading

Conditions: Acute Respiratory Failure

Summary: in this study patients who are intubated and on ventilator for more than 24h will be ventilated at three different level of support in pressure support and neural pressure support to study patient-ventilator synchrony and muscle unloading.

this study is an interventional randomized crossover study in intubated and mechanically ventilated patients for more than 24h. eligible patients from whom informed consent is obtained and pes and edi catheter are successfully positioned are enrolled in the study. patients will be ventilated in pressure support and neural pressure support at three different level of assist (baseline, 50% and 150% of baseline respectively) in randomized order. ventilator curves will be recorded and bloodgas obtained at the end of each study step, each lasting 20min.

Eligibility criteria:
inclusion criteria: -patients intubated for more than 24 hours in the weaning phase from the ventilator. exclusion criteria: * bleeding disorders (pk inr\>1,5 or aptt\>50s or platelet count \<50000/µl) * unstable circulation (requiring high vasopressor dose, for example noradrenalin \>0,2µg/kg/min) * severe lung disease (pfi ≤ 13,3 kpa) * fever\> 38,5°c * pregnancy.
application of decision analysis techniques' in huge health-checkup database to explore the high-risk group with metabolic syndrome

Conditions: Mets

Summary: application of decision analysis techniques' in huge health-checkup database to explore the high-risk group with metabolic syndrome (mets)

according to the american heart association（aha）modified adult treatment panel iii（atp-iii） and the criteria of health promotion administration, taiwan. five indices are used to define metabolic syndrome（mets): including waist circumference （wc), high blood pressure（h/p）, fasting plasma glucose（fpg）, triglyceride（tg）, and high-density lipoprotein-cholesterol（hdl-c）. the recent researches showed us, there was no research applying the five criteria into their decision model. this study proposal will be the first study which evaluated the importance of the criteria related to apply these indices and decision model into the clinic for risk factors assessment. this study was divided into 2 stages: (1) to analyze the big database of health examination to find out the major decision-making analysis module of mets, including the level of importance and decision-making weight of 5 indicators, which can be provided as reference for suggestions on clinical medical treatments or health education focuses of health management of sub-health population; (2) to analyze other demographic variables of the database (educational background, residence, occupation, etc.) and the variables affecting health patterns (including smoking, drinking, long-term sitting work pattern) to find out the important variables affecting high risk group for mets among populations of all ages, in order to investigate the improvement strategies for early prevention or intervention of important variables. as aging society is coming, it is estimated that the elderly people over the age of 65 in taiwan will reach 20% by 2025. according to the estimation of executive yuan, the growth rate of healthcare service industry will reach at least 17%, and the annual output value will reach usd 18 billion. therefore, this study intends to develop strategies for preventing chronic illness in the middle-aged and elderly people and find out the characteristic variables of high risk group according to different age groups to further reduce the incidence of mets or cvd.

Eligibility criteria:
inclusion criteria: 1. in 2006-2016, the mj health research foundation's member,which continuously tested twice or more of the annual health check database , about 90,000 people. 2. the person who was in charge of the taxi driver health checkup project commissioned by the new north city transportation bureau at far eastern memorial hospital, data period 2012-2016, about 2,000 people. exclusion criteria: * no

Keywords: metabolic syndrome（mets） classification decision tree risk factors assessment
effect of postvitrectomy proactive use of conbercept on postoperative complications in pdr patients

Conditions: Proliferative Diabetic Retinopathy

Summary: this is an unmasking randomized clinical trial. the main purpose of this study is to analyze whether posvitrectomy proactive use of conbercept can reduce the rate of postoperative complication in pdr patients.


Eligibility criteria:
inclusion criteria: * pdr patients undergoing vitrectomy exclusion criteria: * patients who had received intravitreal injection or systemic use of all types of anti-vegf agents in the recent three months before vitrectomy * patients who had received intravitreal injection or systemic use of all types of steroid in the recent one month before vitrectomy * patients who had received complete prp before vitrectomy * patients who are pregnant

Keywords: vitrectomy
hernia exploration or not in infants analysis

Conditions: Inguinal Hernia

Summary: this study evaluates the effectiveness and cost-effectiveness of contralateral surgical exploration during unilateral inguinal hernia repair in children younger than six months with a unilateral inguinal hernia. in half of the participants contralateral exploration will be performed, while in the other half only unilateral inguinal hernia repair will be performed.

there is a high incidence of metachronous (i.e. a second) contralateral inguinal hernia (mcih) in infants with an inguinal hernia (5-30%, most studies report 10%), with the highest risk in infants aged less than 6 months. metachronous hernia is associated with the risk of incarceration and general risks and costs of a second operation. this can potentially be avoided by contralateral exploration at the first operation. on the other hand contralateral exploration may turn out to be unnecessary, is associated with additional operating time and cost, and may be associated with additional complications of surgery (including testicular atrophy, wound infection) and anesthesia. both policies to routinely explore the contralateral side or not are used in the treatment of unilateral inguinal hernias in children. there is no high-grade level of evidence of the superiority of one of either policy.

Eligibility criteria:
inclusion criteria: infants aged younger than six months at first presentation with a primary unilateral inguinal hernia undergoing open hernia repair are considered eligible for inclusion. exclusion criteria: infants with (1) incarcerated inguinal hernia requiring urgent surgery, (2) a ventricular-peritoneal drain, (3) non-descended testis.

Keywords: metachronous contralateral inguinal hernia hernia repair contralateral exploration cost-effectiveness infants
prophylactic ceftizoxime (cefizox) for elective cesarean delivery

Conditions: Caesarean

Summary: ceftizoxime (cefizox) will reduce post cesarean delivery febrile morbidity.


Eligibility criteria:
inclusion criteria: * elective cesarean section exclusion criteria: * diabetes severe anaemia allergy

Keywords: ceftizoxime cesarean post caesarean febrile morbidity
tween sleep patterns, appetite control, and environment

Conditions: Child Obesity; Eating Behavior; Sleep

Summary: the goal of this study is to learn about how children's sleep is related to their eating behaviors the next day, and to learn about factors that relate to eating behaviors and sleep health that are specific to preadolescent children living in rural communities.

the aims of this study are to a) describe the prevalence and characteristics of eating in the absence of hunger (eah) in rural preadolescent children using a novel methodology, ecological momentary assessment (ema); b) to examine the within-person temporal relationship between daily changes in sleep health (i.e., duration and quality) and eah; and c) examine associations between family, child, and environmental characteristics, sleep, and eating behaviors in rural preadolescent children. parent-child dyads will participate in the study via remote data collection methods including zoom interviews, online surveys, ema survey completed by smartphone, and actigraphy.

Eligibility criteria:
child inclusion criteria: 1. age 8 to 12 years 2. primary residence is in a rural zip code in the united states, as defined by health resources \& services administration 3. bmi for age ≥ 85th percentile or bmi ≥ 15th percentile plus at least one biological parent with bmi ≥ 25 kg/m2 4. able to read and answer questions in english parent inclusion criteria: 1. parent or caregiver of an eligible child 2. age 18 years or older 3. able to read and answer questions in english exclusion criteria: 1. any medical condition that significantly impacts eating, sleep, growth, or ability to operate the mema smartphone platform (e.g., eating disorder, type i diabetes, blindness) (child participants only) 2. unable to connect to a zoom session via internet or cell-phone data from home 3. unable to receive and sign for package with study supplies

Keywords: sleep eating in the absence of hunger eating preadolescent rural actigraphy ecological momentary assessment
treatment use study for advanced melanoma.

Conditions: Advanced Unresectable Melanoma

Summary: the purpose of this study is to provide access to cp-675,206 for patients with advanced unresectable melanoma and who have the potential to gain benefit from this treatment and who are not eligible for participation in other cp-675,206 studies.

this is an expanded access trial that canceled prior to enrolling patients.

Eligibility criteria:
inclusion criteria: * advanced melanoma with life expectancy of at least 6 months. * melanoma must be considered unresectable. * patients with stable, treated brain mets must be stable clinically and radiographically and off steroids for at least one month. exclusion criteria: * patients must not be eligible for participation in any ongoing cp-675,206 clinical studies currently open for enrollment. * history of chronic inflammatory or autoimmune disease. * history of inflammatory bowel disease, celiac disease, or other chronic gastrointestinal conditions associated with diarrhea, active colitis, history of diverticulitis.