Kornimate/medical-research-clean huggingface dataset:
beam copd: breathing, education, awareness and movement in chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the main purpose of this study is to determine feasibility and effects of tai chi and mind-body breathing in patients with copd.


Eligibility criteria:
inclusion criteria: 1. moderate-severe copd 2. age ≥ 40 years exclusion criteria: 1. subjects with respiratory failure or gold stage 4 who are unable to safely perform a 6 minute walk test or otherwise safely exercise as deemed by a physician. 2. copd exacerbation requiring steroids, antibiotics, ed visit or hospitalization within the past 2 weeks unless physician deems subject at baseline 3. planned major pulmonary intervention within the next 3 months 4. hypoxemia on walk test or cardiopulmonary exercise test 5. inability to ambulate due to vascular or other neuromuscular conditions that would preclude a walk test 6. clinical signs of unstable cardiovascular disease 7. severe cognitive dysfunction 8. non-english speaking 9. current active participation in pulmonary rehabilitation program or current regular practice of tai chi 10. physician diagnosis of unstable/untreated clinical depression 11. history of lung cancer

Keywords: chronic bronchitis emphysema pulmonary copd
crossover study on the effect of omegaven in combination with different lipid emulsions in home parenteral nutrition

Conditions: Parenteral Nutrition

Summary: the aim of this study was to evaluate the safety and tolerance of clinoleic or lipoplus or smoflipid lipid emulsions. after 6 weeks of each lipid emulsion, omegaven (fish oil) was added for a further 4 weeks. the safety and tolerance was evaluated after each lipid emulsion cycle by biochemistry, hematology and coagulation variables, vital signs and adverse events. we also analysed fatty acid profiles in plasma or erythrocyte phospholipids, antioxidant enzyme activities, lipid peroxidation products, plasma lipids and pro-inflammatory cytokine production after in vitro stimulation of whole blood by lipopolysacharide in hpn patients. the non-interventional group of healthy controls was included for comparison.

intravenous lipid emulsions (les) are an indispensable part of home parenteral nutrition (hpn). all commercially obtainable les are applicable for hpn in providing a source of energy and essential fatty acids. the originally used soyabean oil-based le (intralipid) have been suspected of being associated with a higher risk of pro-inflammatory lipid-mediator production due to their high content of n-6 polyunsaturated fatty acids. the more modern mixes of soyabean oil, and/or olive oil, and/or fish oil les with beneficial responses compared with intralipid are available. given that there are no clear clinical recommendations for le application in hpn, we performed this cross-over design, phase 4 study comparing clinoleic, lipoplus or smoflipid in chronic intestinal failure patients with additional escalation of fish oil using omegaven.

Eligibility criteria:
inclusion criteria: * home parenteral nutrition patients in need of parenteral nutrition administration \> 4 days/week * parenteral duration expectancy \> 8 months * stable clinical condition without any complications in the past 2 months * written consent from the subject exclusion criteria: * known hypersensitivity to any of the active substances or excipients * unstable conditions * active cancer or its treatment * established immunodeficiency * advanced organ dysfunction from chronic disease

Keywords: lipid emulsion olive oil fish oil intestinal failure home parenteral nutrition
the impact of prehabilitation

Conditions: Post Operative Complications

Summary: while numerous studies have assessed the promising impacts of prehabilitation, there is a lack of prehabilitation research within lower socioeconomic patient populations. often for prehabilitation studies, patients are heavily involved in full scale exercise and nutrition programs weeks before the scheduled procedure. in underserved populations, programs such as these are often not feasible due to lack of transport, resources, and other barriers to healthcare. the investigators seek to evaluate the effectiveness of inexpensive interventions in lower socioeconomic populations. the investigators hypothesize that barriers to prehabilitation are environmental and that prehabilitation interventions tailored for lower socioeconomic (ses) populations will improve time to discharge, mobility, and in turn, readmission rates. the participants for this clinical trial will be seen four times: initially at the preoperative surgical clinic (6-8 weeks prior to surgery), 1-2 days preop at a pre-procedure clinic, postoperative in the inpatient setting (as soon as the participant is able to ambulate during their hospital stay), and in the postoperative surgical clinic at the postoperative visit. patients will be within the general surgery, colorectal, and surgical oncology departments at boston medical center (bmc). the anticipated sample size is 60 participants (30 in the intervention/prehabilitation arm and 30 in the control/usual care arm). participants in the intervention arm will participate in a mobility and step tracking intervention aimed at improving postoperative outcomes. the control group will follow routine standard of care at bmc for preoperative and postoperative care.


Eligibility criteria:
inclusion criteria: * patients within general surgery, colorectal, and surgical oncology departments at boston medical center. * english or spanish speaking * able to ambulate without cane, walker, wheelchair * surgery scheduled within 4-8 weeks * must have cell phone with internet access and text message capabilities * jh-hlm score of 6 exclusion criteria: * limited/non readers (less than 5th grade reading level), assessed via comprehension of consent materials

Keywords: prehabilitation patient video education instructional walking video 6 minute walking test patient texting
role of pancreatic triglyceride content in beta-cell function

Conditions: Obesity; Type 2 Diabetes

Summary: the study evaluates if fat accumulates in the pancreas in individuals at risk of developing obesity-related diabetes. it also evaluates if the amount of fat in the pancreas can predict the residual functional capacity of the pancreas (insulin secretion).


Eligibility criteria:
inclusion criteria: * adults without prior history of pancreatic disease (other than diabetes) exclusion criteria: * use of unapproved medications * contraindications to the mri procedure * contraindications to frequent blood draws * pregnancy * use of more than 2 alcoholic drinks/day
the effectiveness of virtual reality based rehabilitation in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: we aimed to investigate the effects of virtual reality based rehabilitation program on patients with knee osteoarthritis.

sixty volunteer participants with knee osteoarthritis aged 40 to 65 years who were at stage of 2-3 according to the kellgren lawrence radiological evaluation were included in the study. participants were randomly divided into two groups as virtual and control group. while a conventional physiotherapy program consisting of electrotherapy and exercise program was applied to both groups 5 days a week for 6 weeks, a virtual reality program was added to the virtual group for 6 weeks, 5 days a week. at the beginning of the treatment and at the end of the sixth week, rom, pain, kinesiophobia, proprioception, balance, muscle strength and functional status were evaluated between groups.

Eligibility criteria:
inclusion criteria: * knee osteoarhritis aged 40 to 75 years who were at stage of 2-3 according to the kellegren lawrence radiological evaluation were included in the study. exclusion criteria: * those who have received physical therapy in the last 6 months * having serious systemic and cardiovascular diseases that may prevent exercise * neurological and orthopedic problems affecting gait * those with sensory defects * malignancy diagnosed * those who have received prp (platelet-rich plasma) treatment or intra-articular steroid injection treatment in the last 6 months * with metal implants * serious hearing loss or visual impairment * communication problems

Keywords: knee osteoarthritis virtual reality rehabilitation balance kinesiophobia
evaluation of plasma concentrations of intravenous lidocaine and epidural ropivacaine when used in combination in major abdominal surgery

Conditions: Abdominal Surgery by Laparotomy; Thoracic Epidural Analgesia; Analgesia; Lidocaine Adverse Reaction

Summary: thoracic epidural analgesia (tea) is the gold standard analgesia of the laparotomy in major abdominal surgery and can be associated with intravenous lidocaine or subtituted by intravenous lidocaine when tea is contraindicated and in order to reduce the use of the morphinics in the perioperative period. side effects can be paralytic ileus or nausea and vomiting and delay the enhanced recovery after surgery. intravenous lidocaine and tea share several properties like anti hyperalgesia, anti inflammatory effect, intestinal process, anti tumoral effect... which suggests an additive effect of their combination that was not studied yet.


Eligibility criteria:
inclusion criteria: * abdominal surgery by laparotomy exclusion criteria: * laparoscopic abdominal surgery, * tea contraindication, * ropivacaine contraindication * intravenous lidocaine contraindication

Keywords: abdominal surgery by laparotomy thoracic epidural analgesia analgesia lidocaine adverse reaction
a novel approach utilizing organ specific age proteomics

Conditions: Breast Cancer

Summary: this study compares changes in p16ink4a expression and plasma proteomic signatures of specific organ age pre- and post-chemotherapy in women treated with adjuvant chemotherapy for early-stage breast cancer. it aims to determine if biological and accelerated immune aging, assessed using t cells from peripheral blood, represents aging in different organs. patients receiving chemotherapy, especially adjuvant regimens that include anthracyclines and taxanes, often experience late development of cardiac toxicity, functional loss, and cognitive decline. comparing baseline characteristics with organ aging before therapy might identify patients at the highest risk for chemotherapy complications. for example, this is clinically significant for patients whose therapy includes taxanes or other drugs known to cause peripheral neuropathy. identifying aging in the neurological or vascular systems before treatment might lead to changes in regimens. determining accelerated aging in specific organs allows for investigating interventions to mitigate organ damage. for instance, identifying patients at the highest risk of cardiac aging after treatment could lead to testing the effects of exercise, senolytics, and other strategies to reduce the risk of long-term heart disease.

chemotherapy has revolutionized cancer treatment, significantly improving relapse-free and survival rates for many cancers. however, these advances have come with a downside, and nowhere is this more evident than in childhood cancer. despite the significant advances in the curability of most childhood cancers, up to 20% of patients die of comorbidity and secondary cancers by the age of 35 years. recent research shows that a plasma proteomic measure of protein abundance and expression can provide a" global" proteomic signature that accurately predicts chronologic age in the general population. it was shown that accelerated organ aging conferred a 20-50% higher mortality risk, and this was pronounced for those with accelerated cardiac and brain aging. previous studies have shown that p16ink4a, a robust biomarker of cell senescence measured in peripheral blood t cells, rises dramatically and likely irreversibly after adjuvant therapy for breast cancer. for anthracycline regimens, p16ink4a changes suggest 10 to 20 years of accelerated aging shortly after treatment. additionally, in murine models, changes in p16ink4a are seen in all organs as mice age, but not all organs age at the same rate.

Eligibility criteria:
inclusion criteria: * age ≥22years and \<66 years * diagnosed with early-stage breast cancer (the american joint committee on cancer stages i-iii). * understand and read english. * receive care at the study site. * able to understand and participate in study procedures for length of study. exclusion criteria: * unable to provide consent, unable to communicate verbally. * unable to understand or read english. * enrolled in hospice care.

Keywords: proteomic plasma proteomic p16ink4a chemotherapy t cells aging morbidity
the effects of exoskeleton robotic training device on upper extremity in brain injury patients

Conditions: Chronic Stroke

Summary: the purpose of this study is to examine the effects of the emg-driven exoskeleton hand robotic training device on upper extremity motor and physiological function, daily functions, quality of life and self-efficacy in brain injury patients.

the purpose of this study was to 1) examine the effects of emg-driven robot-assisted intervention, and 2) examine whether the robot-assisted therapy is as effective as conventional intervention. the study was conducted using a randomized, two-period crossover design. participants were randomly assigned to group 1 or group 2 using a computer-generated list. participants in group 1 received 12 sessions of robot-assisted intervention first, followed by a one-month washout period, and then received 12 sessions of conventional intervention. participants in group 2 received 12 sessions of conventional intervention first, followed by a one-month washout period, and then received 12 sessions of robot-assisted intervention. outcome measures were performed before the intervention, after the first 12-session intervention, and after the second 12-session intervention.

Eligibility criteria:
inclusion criteria: 1. unilateral stroke ≥ 3 months prior to study enrollment 2. fugl-meyer assessment for upper extremity (fma-ue) score \<60 3. without excessive spasticity in any of the ue joint (modified ashworth scale ≤3) 4. mini mental state exam (mmse) score \> 24, indicating no serious cognitive impairment 5. between the ages of 20 and 75 years. exclusion criteria: 1. histories of other neurological diseases such as dementia and peripheral polyneuropathy 2. difficulties in following and understanding instructions such as global aphasia 3. enroll in other rehabilitation or drug studies simultaneously 4. receiving botulinum toxin injections within 3 months.
assessing the effectiveness of bfa as a non-pharmacologic pain management intervention: a randomised sham controlled study

Conditions: Assessing the Effectiveness of BFA as a Non-pharmacologic Pain Management Intervention: A Randomised Sham Controlled Study

Summary: this is a randomized sham controlled study that will include patients hospitalized in the internal medicine department and the orthopedics department at bnei zion hospital presenting with pain from various sources with an nrs level equal to or above 4.

all patients will complete pain assessment according nsr and esas after treatment ( sham or bfa) one hour before and every 24 hours until discharge. if there was no sufficient improvement in pain within 24 hours (decrease of 1.5 points or more in nrs) - additional acupuncture will be performed in the contralateral ear and repeated assessments as above.

Eligibility criteria:
inclusion criteria: -1.pain of skeletal muscle origin (musculoskeletal msk)/rheumatological/orthopedic syndromes 2.visual analog score (vas) grade 4 or higher before receiving the treatment. 3.eligible to participate in the study according to the assessment of the investigator exclusion criteria: 1. pain syndromes of non-muscular bony/rheumatological/orthopedic origin 2. planned an mri next week 3. an infectious process in the ear planned for acupuncture or a history of sensitivity to metal 4. have any participant condition that ' according to the investigator ' could interfere with the conduct of the trial -
narrative exposure therapy (net)

Conditions: Posttraumatic Stress Disorder

Summary: the purpose of this study is to learn more about narrative exposure therapy for justice involved veterans. this pilot study will examine the feasibility of this intervention in a justice-involved veteran population, and will see whether the intervention needs to be tailored to best meet their needs. the investigators will examine whether the intervention impacts key clinical outcomes, including posttraumatic stress disorder symptoms, as well as on measures of moral injury, anger, depression, suicidality, and aggression.

the overall objective of this application is to gather data on the use of narrative exposure therapy for justice involved veterans (vetnet) in a pilot sample of justice-involved veterans with ptsd, with a particular focus on obtaining data on feasibility and acceptability of the intervention in a justice-involved veteran population, and determining what further adaptations are needed to tailor this intervention to justice-involved veterans (jiv). the investigators are also interested in evaluating whether the intervention has the potential to have an effect on key clinical outcomes, including posttraumatic stress disorder (ptsd) symptoms, as well as on measures of moral injury, anger, depression, suicidality, and aggression. the following specific aims have been developed for this project: aim 1: evaluate study feasibility and treatment delivery procedures of narrative exposure therapy for justice involved veterans (vetnet) in justice-involved veterans (jiv) with ptsd. data gathered will include recruitment rates, drop-out rates, adverse event frequency and severity, and participant engagement in treatment. as necessary, identify further adaptations that are needed to tailor this intervention specifically to jiv. aim 2: evaluate the impact of vetnet on ptsd symptoms, as well as on related outcomes including moral injury, anger, depression, suicidality, and aggression.

Eligibility criteria:
inclusion criteria: * is a veteran; * recent justice involvement including current probation, parole, or house arrest, or having been released from jail or prison within the past 1 year; * meets current criteria for ptsd. exclusion criteria: * currently incarcerated; * current, active psychosis; * is at imminent risk for suicide or homicide warranting immediate intervention; * substance abuse that is severe enough to prevent full engagement in the study protocol; * concurrent trauma-focused psychotherapy including prolonged exposure therapy, cognitive processing therapy, or emdr; * is unable to unwilling to complete study procedures.

Keywords: posttraumatic stress disorder criminal justice veterans
a nasal spray with glucose oxidase as a treatment of common cold

Conditions: Common Cold

Summary: healthy persons are invited to participate in the study and are given a home protocol (wurss21), nasal spray and a sample pin. the included persons are told to make a nasopharyngeal sampling from the nose when they are sure that they have caught a common cold. after the sampling they start to spray and also fill in the records daily. the aim of the study is to investigate whether a nasal spray with glucose oxidase could shorten an episode of common cold.

persons working in a military unit in boden and persons connected to the department of sports medicine in umeå were invited to participate in this study. only persons older than 18 years was included in the study. the persons included received one bottle of study medicine, a home protocol (wurss 21) and a viral sampling kit. whenever the included persons were sure that they had received an episode of common cold they were told to perform a viral sampling from the nose, fill in the protocol and start to use the nasal spray several times daily for one week. the treatment was either a) a saline solution with 5% glucose or b) a saline solution with 200u/ml of glucose oxidase and 5%glucose (active treatment group). the combination of glucose oxidase and glucose produces an acid environment, imitating the effect of the normal nasal flora and human rhinoviruses are sensitive to an acid environment. after one week of treatment and daily records of the wurss 21 protocol the persons returned the spray bottles (bag-on-valve), the virus vials and the protocols. a total of 146 persons were included in the study and 98 persons returned protocols.

Eligibility criteria:
inclusion criteria: * healthy adults exclusion criteria: * ongoing allergy
iop fluctuations in patients with primary open-angle glaucoma, before and after selective laser trabeculoplasty

Conditions: Primary Open Angle Glaucoma; Pigmentary Glaucoma; Pseudoexfoliative Glaucoma

Summary: selective laser trabeculoplasty (slt) is an increasingly popular treatment modality in early-to-moderate glaucoma patients. slt has been suggested to reduce iop more consistently during the nocturnal period than during the diurnal period in a group of medically-treated patients with primary open angle glaucoma (poag). at present, there is scarce data on slt effects on the 24-hour iop pattern in patients with glaucoma and there is no data on the 24-hour effect of slt in untreated glaucoma patients. the purpose of this study is to assess the changes of iop over a 24-hour period in patients with glaucoma undergoing slt.


Eligibility criteria:
inclusion criteria: * diagnosis of primary open angle glaucoma (poag) including pigmentary glaucoma or pseudoexfoliative glaucoma (pex) * documented glaucomatous vf damage (in the previous 8 months) with mean defect (md) \> 2.5 db * no or stable anti-glaucomatous drug therapy since at least 3 months * structural and/or functional glaucomatous damage * aged more than 18 years, of either sex * not more than 6 diopters spherical equivalent on the study eye * not more than 2 diopters cylinder equivalent on the study eye * have given written informed consent, prior to any investigational procedures exclusion criteria: * refractory glaucoma * patients having undergone ocular laser procedures or intraocular surgery for the treatment of glaucoma * corneal or conjunctival abnormality precluding contact lens adaptation * severe dry eye syndrome * patients with allergy to corneal anesthetic * patients with contraindications for silicone contact lens wear * patients not able to understand the character and individual consequences of the investigation * participation in other clinical research within the last 4 weeks * any other contra-indication listed in the triggerfish user manual

Keywords: glaucoma slt