Kornimate/medical-research-clean huggingface dataset:
integrated care for frail older people

Conditions: Frail Elderly Syndrome

Summary: this is a qualitative interview study investigating patients', carers' and providers' perspectives on integrated care and integrated care pathways for frail older people in lambeth and southwark, south london.


Eligibility criteria:
inclusion criteria: 1. frail older people aged 65 years and over, including men and women with different levels of frailty. 2. carers (family member, friend or neighbor) identified by the frail older participant as a main carer. 3. health and social care professionals, care workers, service managers and commissioners working in different parts of the local health and care system (primary, secondary, community, social and voluntary care), reflecting a range of roles. exclusion criteria: 1. older people not identified as frail. 2. frail older people who are unable to provide their informed consent to take part in the study, for example due to significant cognitive impairment.
role of glucose metabolism in migration of cutaneous dendritic cells in psoriasis

Conditions: Psoriasis

Summary: dendritic cells (dc) paly a key role in the induction and chronicity of psoriasis by capturing the antigenes and activating the t cell repsonse. this activation requires their migration from the cutaneous sensitisation site to the lymph nodes. this migration requires an important intracellular metabolic activity, with a strong involvmenet of glucdic metabolism. this activity is linked with the systemic activity. this study aims to compare the migration and the phenotypic and metabolic caracteristics of blood and skin dcs in patients with or without psoriasis and with or without type 2 diabetes,


Eligibility criteria:
inclusion criteria: * patients of both sexes * hospitalized in the dermatology department of the chu of nice for moderate to severe psoriasis (defined by a pasi \> or = 10) * covered by a social security scheme after obtaining a free * clinical diagnosis of plaque psoriasis by a dermatologist with or without type 2 diabetes (defined by glycated hemoglobin \>7%) * for the control group: without psoriasis or other inflammatory dermatosis aged in the presence or not of type 2 diabetes (glycated hemoglobin \>7%). * free and informed consent exclusion criteria: * minor or incapable or unwilling to consent freely or in an informed manner pregnant or nursing woman. * patient in a period of exclusion from other biomedical research * patient with generalized chronic inflammatory disease or other inflammatory dermatosis * patients on general corticosteroid, immunomodulator or immunosuppressant therapy in the month prior to local inclusion or treatment with corticosteroid therapy in the 15 days prior to inclusion, on anti- treatmentil-23 or anti il12/23 for less than 3 months or under anti-il-17 or anti-tnf treatment for less than 1 month. * contraindication to cutaneous biospsis (known hemostasis disorder, taking anticoagulants, allergy to xylocaine, history of cheloid scars, congenital immune deficiency)
primary headaches and irritable bowel syndrome.

Conditions: Primary Headache Disorder

Summary: to assess the relationship between primary headaches and irritable bowel syndrome

the association between primary headaches and functional gastrointestinal disorders has been confirmed by many clinical observations. in most patients during the attacks of headache, apart from various neurological and vascular symptoms, gastrointestinal disturbances occur . functional gastrointestinal disorders, such as irritable bowel syndrome (ibs), are reported in primary headache patients in periods between the attacks as well. on the other hand 23-53% of ibs patients have frequent headaches. migraine typically presents relapsing episodes of symptoms including headache, nausea, vomiting, sensory hypersensitivity and mood changes that last for hours to days . similar to migraine, ibs is characterized by recurrent abdominal pain or discomfort with altered gastrointestinal motility and visceral hypersensitivity that returns to normal between attacks . both pain disorders lack detectable organic causes . an emerging model of the brain-gut axis was proposed to explain migraine and ibs as a result of a genetically sensitive nervous system that develops hyperexcitability over time as a response to multiple environmental and immunological factors. cluster headache (ch) characterized by its distinctive circadian and circannual periodicity, implicating the role of the hypothalamus in its underlying pathophysiology. ch and ibs are featuring recurrent attacks of pain that possess relationships with circadian rhythms and potentially hypothalamic derangements. tension headache that's associated with pain in head described as feeling like a tight band around head, also show many similarities with ibs such causes for both are unknown, and some studies suggest a possible link that could shed light on shared genetics of both condition .

Eligibility criteria:
inclusion criteria: * age more than 18. * both sex. * history suggestive of any type of primary headaches. * accept to participate in the study. exclusion criteria: * intake of medications that can aggravate headache or ibs. * presence of neurological disease other than primary headaches. * presence of gastrointestinal disease other than ibs.
cold vibratory stimuli on pain perception governing infiltration anesthesia in in children

Conditions: Anesthesia, Local

Summary: local anesthesia injections are sometimes painful, resulting in antagonistic cooperation, fear, and anxiety in children. this study aims to investigate the effectiveness of vibratory and cold stimulation before the injection to reduce pain. purpose of the study: evaluate the effectiveness of buzzy® in pain reduction during local anesthesia administration compared to the traditional topical anesthetic gel in pediatric patients.


Eligibility criteria:
inclusion criteria: * patients who are in need of extraction of maxillary posterior teeth. * children free of any systemic disease or special health care needs (asa i). * children with no learning disabilities. * positive or definitely positive behavior during preoperative assessments according to the frankl scale. * patients whose parents will give consent to participate. exclusion criteria: * having active sites of pathosis in the area of injection that could affect the anesthetic assessment. * signs of reversible pulpitis. * restorable tooth. * patients allergic to local anesthesia or having a family history of allergy to local anesthesia. * patients with acute oral or facial infection (swelling and/or cellulites )

Keywords: dental injection palatal injection indirect palatal injection
addressing medication non-adherence in patients with poorly controlled hypertension using urine mass spectrometry

Conditions: Hypertension; Uncontrolled Hypertension; Non-Adherence, Medication

Summary: * hypertension is the single largest contributor to cardiovascular disease and death. while adequate control of hypertension reduces risk of disease, many patients have uncontrolled hypertension. this is often due to medication non-adherence. left undetected, patients are prescribed additional medications, and referred to multiple specialists for investigations - leading to increased healthcare costs. hence, detecting non-adherence to antihypertensive medications is important. however, patient history, patient recall, or questionnaires, are often inaccurate. most recently, urine measurements of antihypertensive drug levels, using mass spectrometry, has been established as the gold standard to assess medication adherence. the one-time urine test for medication adherence is ideal: it's convenient, non-invasive, economical, and can be easily performed in a clinic setting. by improving blood pressure control, this will lead to reductions in healthcare visits, avoidance of catastrophic cardiovascular events. ultimately, this translates to significant economic savings for both patients with hypertension and the healthcare system. * therefore, the investigators hypothesize that the implementation of urine adherence testing coupled with targeted counselling will improve the adherence and blood pressure control in hypertension. to do this, the investigators aim to (1) evaluate for medication adherence in 312 participants with recent stroke and hypertension; (2) evaluate for medication non-adherence in participants with uncontrolled hypertension; and (3) assess if detection of non-adherence can improve hypertension control.

• the investigators plan to achieve these aims in three steps. first, the investigators retrospectively assess medication adherence in 200 participants admitted for recent stroke using urine biospecimens collected. second, the investigators will prospectively recruit 100 participants with poorly controlled hypertension and assess for medication adherence. finally, participants detected with non-adherence will be counselled. these participants will be reassessed for improvements in both medication adherence and blood pressure.

Eligibility criteria:
inclusion criteria: 1. age of 21 - 80 years 2. systolic blood pressure of ≥140 mmhg or average systolic blood pressure ≥135 mmhg, or diastolic blood pressure ≥90 mmhg or average diastolic blood pressure ≥85 mmhg, on at least two measurements 3. currently taking 2 or more hypertension medications 4. able to provide informed consent. exclusion criteria: * significant kidney impairment with egfr of less than 45ml/min/1.73m2 or on dialysis * known history of chronic liver disease

Keywords: urine mass spectrometry uncontrolled hypertension medication non-adherence
study of magnesium sulfate in children with reduced bone density secondary to chronic cholestatic liver disease

Conditions: Alagille Syndrome; Cholestasis; Biliary Atresia

Summary: objectives: i. determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin d and reduced bone density in children with chronic cholestatic liver disease.

protocol outline: patients receive magnesium sulfate iv over 1 hour on day 3. patients then receive oral magnesium gluconate supplementation daily. treatment with magnesium sulfate repeats once at 3-6 months.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- * diagnosis of liver disease with chronic cholestasis nonsyndromic intrahepatic cholestasis alagille's syndrome extrahepatic biliary atresia * direct bilirubin greater than 2 mg/dl or bile acids greater than 20 micromoles/l * no hepatic decompensation defined as one or more of the following: ascites peripheral edema pt at least 4 seconds longer than control albumin less than 3 g/dl --patient characteristics-- * renal: no significant renal disease * cardiovascular: no significant cardiovascular disease * pulmonary: no significant pulmonary disease

Keywords: alagille syndrome biliary atresia cholestasis gastrointestinal disorders rare disease
lanreotide autogel 120 mg at extended dosing intervals (>4 weeks) in acromegalic subjects

Conditions: Acromegaly

Summary: the purpose of this study is to evaluate the effectiveness in igf-1 control of lanreotide autogel (atg) 120 mg at extended dosing intervals (edis) (\>4 weeks) in subjects with acromegaly in daily clinical practice.


Eligibility criteria:
inclusion criteria: * men or women aged ≥ 18 years * diagnosed with acromegaly * receiving treatment with atg 120 mg at extended dosing intervals (\> 4 weeks) for at least six months before the study visit. * assay data (blood gh and igf-1 levels) from immediately before the study visit (performed at least six months after starting the treatment) is available. * able to sign the informed consent form for study participation. exclusion criteria: * received radiation therapy treatment in the last six months. * active participation in another clinical study. * physical or mental disorders that, in the investigator's opinion, could affect their ability to sign the informed consent form. * pregnancy or breastfeeding for female patients. * no data in their medical records on the treatment start date for atg 120 mg at extended dosing intervals or on changes to the schedule of administration over the last six months.
comparison of extra vascular lung water index in covid-19 ards and "typical"ards patients

Conditions: Respiratory Distress Syndrome, Adult; Ventilation Perfusion Mismatch; Pulmonary Edema; Covid19

Summary: covid-19 also primarily affects endothelium that line up the alveoli. the resulting hypoxemia may differ from "typical" acute respiratory distress syndrome (ards) due to maldistribution of perfusion related to the ventilation. thus, pathophysiology of covid-19 ards is different, which requires different interventions than typical ards. the investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ards with transpulmonary thermodilution (tptd) technique. extravascular lung water index (evlwi) and pulmonary vascular permeability index (pvpi) will be compared.


Eligibility criteria:
inclusion criteria: * ards defined by berlin criteria longer than 24 hours * undergoing mechanical ventilation * noradrenaline demand \>0.1 mcg/kg/min exclusion criteria: * not meeting ards criteria * noninvasive mechanical ventilation * ards resolved shorter than 24 hours * shock resolved

Keywords: ards covid19
[18f]fes pet/ct in pah

Conditions: Pulmonary Arterial Hypertension

Summary: in this study positron emission tomography (pet/ct) imaging will be used to evaluate evaluation of estrogen receptor heterogeneity and functionality in pulmonary arterial hypertension (pah) using the investigational radiotracer \[18f\]fluoroestradiol (fes).

this is a feasibility study of serial fes scanning in female patients with pulmonary arterial hypertension (pah) to determine whether patients have detectable changes in fes suv following treatment with fulvestrant on the separate therapeutic protocol irb# 824861 "estrogen receptor antagonist in patients with pulmonary arterial hypertension (era pah)". subjects will undergo up to 2 \[18f\]fes pet/ct scans for this protocol. a baseline fes pet/ct will occur on day 0 (-2 days) of the companion treatment trial prior to initiation of fulvestrant. the second fes pet/ct scan will occur on week 9 (63 ± 7 days) after initiation of fulvestrant. we will compare suv values after fulvestrant to pre-treatment values.

Eligibility criteria:
inclusion criteria: * 1. women who are post-menopausal, defined as one of the following 1. \> 50 years old and a) have not menstruated during the preceding 12 months per medical record review or self-report or b) have follicle-stimulating hormone levels \> 40 iu/l at screening or 2. \ 40 iu/l at screening or 3. history of bilateral oophorectomy per medical record review or self-report. 2. diagnosis of pulmonary arterial hypertension (pah) per medical record review. 3. patients must be candidates to receive treatment on the companion therapeutic trial "estrogen receptor-α inhibitor in patients with pulmonary arterial hypertension (era pah)" (irb# 824861 "era pah") 4. participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures. exclusion criteria: * 1. inability to tolerate imaging procedures in the opinion of an investigator or treating physician 2. serious or unstable medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study. 3. ineligible for the therapeutic trial irb# 824861 "era pah" entitled "estrogen receptor antagonist in patients with pulmonary arterial hypertension (era pah)" (irb# 824861 "era pah")

Keywords: pah pulmonary hypertension
deep learning-based system and aids-related cytomegalovirus retinitis

Conditions: Cytomegalovirus Retinitis

Summary: ophthalmological screening for cytomegalovirus retinitis (cmvr) for hiv/aids patients is important. however, the manual screening with fundus imaging is laborious and subjective. deep learning (dl) system has been developed for the automated detection of various eye diseases with high accuracy and efficiency, including diabetic retinopathy, glaucoma, age-related macular degeneration (amd), papilledema, lattice degeneration and retinal breaks, from ocular fundus photographs. uwf imaging is a relatively new imaging modality for dl system but has also shown extraordinary talents in automatic retinal analysis with the press for routine cmvr screening in aids patients and the great capacity of dl system, the use of deep learning (dl) system to aids-related cmvr with ultra-widefield (uwf) fundus images is promising. the investigators previously developed a dl system to detect aids-related cmvr. for further evaluating the applicability of the dl system, a prospective dataset is needed.


Eligibility criteria:
inclusion criteria: the uwf images from hiv/aids patients. exclusion criteria: 1. the uwf images would be excluded if all three human graders gave different diagnosis. 2. the uwf images with poor quality would be excluded.

Keywords: aids hiv cytomegalovirus retinitis deep learning ultra-wide-field imaging
case-control study on individual risk factors of cts

Conditions: Carpal Tunnel Syndrome

Summary: this study is conducted to observe the characteristics of the risk factors of cts in chinese population.

carpal tunnel syndrome (cts), or median neuropathy at the wrist, is a medical condition in which the median nerve is compressed at the wrist, leading to paresthesia, numbness and muscle weakness in the hand. it's the most common neuro-compressive disease. with the development of the modern life, the morbidity of cts is also raised. as a common disease, the study on etiology is very important in carpal tunnel syndrome, which can improve the life quality of patients with carpal tunnel syndrome. the risk factors include individual factors such as age, gender, diabetes, hypothyroidism, obesity, complication of systematic diseases, tobacco, injury and occupational factors. as most of the research were based on the population in western country and the life style and the ethnicity between chinese people and western country people is quite different, there may be some similarities and differences in epidemiology. there is seldom similar research in china so that this study was conducted to observe the characteristics of these risk factors in chinese population.

Eligibility criteria:
inclusion criteria: * with the symptom "numbness" * clinical and neural-electrophysiological diagnosed cts exclusion criteria: * suffered from other diseases that could cause "numbness" diagnosed clinically

Keywords: carpal tunnel syndrome etiology risk factor
relationship of addictions to obesity, physical activity and vascular ageing in young adults

Conditions: Drug Addiction; Technology Addiction; Young Adult

Summary: this is a cross-sectional observational study whose objective is to analyse the relationship between behavioural addictions and drug addictions with obesity, physical activity, sedentary lifestyle, arterial stiffness and vascular ageing in young adults, since many of the lifestyles of adulthood are established early in life, and it is easier to prevent them before they start than to achieve their abandonment once they are established as unhealthy lifestyles

behavioural addictions. brief questionnaire of pathological gambling (cbjp), lie/bet scale, compulsive internet use scale (cius), smartphone dependence and addiction scale (edas-18), questionnaire of experiences related to video games (cerv). drug addictions: alcohol, smoking and substance involvement screening test (assist v3.0), drug abuse screening test (dast-20), alcohol use disorders identification test (audit) and fagerström test. obesity and body composition: weight, height, waist circumference, hip circumference and inbody 230®. diet: mediterranean diet adherence questionnaire. physical activity: international physical activity questionnaire (ipaq), actigraph gtx3 accelerometer and marshall questionnaire. analysis of vascular structure and function and target organ lesions. pulse wave analysis (pwa) and femoral carotid pulse wave velocity (vopcf) (sphygmocor system). cardio ankle vascular index (cavi), ankle-ankle pulse wave (vopbt) and ankle-ankle index (abi) (vasera vs-2000®). retinal vascular injury (topcon trc nw 200). cardiac lesion (general electric 5000). kidney injury: analytical variables. brain injury: montreal cognitive assessment (moca). vascular ageing (vopcf and vopbt). other variables. basal glycaemia, hba1c. tsh, lipid profile, creatinine and creatinine albumin index and vit d. measurement of blood pressure and drug consumption.

Eligibility criteria:
inclusion criteria: * patients between 18 and 34 years of age who agree to participate in the study and do not meet any exclusion criteria. exclusion criteria: * subjects who are terminally ill, who are unable to travel to health centres for the corresponding examinations, and who do not sign informed consent.

Keywords: lifestyles vascular ageing obesity
digital supported compression bandaging in patients with chronic edema in the lower limbs

Conditions: Compression; Vein; Venous Insufficiency; Lymphedema of Leg; Digital Technology

Summary: patients with chronic edema of the lower limb referred to compression bandaging in a hospital setting will be invited to participate in the validation study of a novel sensor (cimon), which have been developed for assessing the effect of compression bandaging. participants will have the sensor applied to the lower limb before initiation of compression bandaging and will receive usual compression treatment according to severity of the edema and usual practice at the treatment site. duration of participation is 14 days.

the cimon sensor is developed with the purpose of monitoring the effectiveness of compression bandaging (cb) in patients with chronic edema by application to the widest circumference of the calf. cimon measures the difference in capacitance by stretching the circumferential sensor. data from the sensor is transferred by bluetooth technology to a secured webserver, where healthcare professionals can monitor the effect of compression bandaging. the study aims to assess the psychometric properties of the cimon (reliability, validity and responsiveness) and assess the correlation between edema reduction and physical activity during compression bandaging.

Eligibility criteria:
inclusion criteria: * chronic edema of the lower limb * referred to compression bandaging * circumference of widest point of the lower leg between 35-75 cm exclusion criteria: * wounds at the lower leg (at the widest circumference of the lower leg) * acute deep venous thrombosis in the leg * untreated cellulitis * severe heart- or kidneyfailure * severe peripheral neuropathy in the lower limbs

Keywords: compression therapy compression bandaging chronic edema psychometrics
interaction between nalbuphine and morphine in pca

Conditions: Postoperative Pain

Summary: 1. nalbuphine is opioid mu receptor antagonist and kappa receptor agonist 2. this study was designed to investigate the interaction between nalbuphine and morphine

1. nalbuphine is opioid mu receptor antagonist and kappa receptor agonist 2. this study was designed to investigate the interaction between nalbuphine and morphine 3. the analgesic effect and opioid-related side effects will be investigated

Eligibility criteria:
inclusion criteria: 1. age 18-65 y/o 2. female patients of asa physical status i to iii 3. scheduled for elective abdominal hysterectomy, myomectomy, or excision of ovarian tumor exclusion criteria: 1. patients with a definite diagnosis of chronic pain syndrome, psychiatric disorders, or drug abuse (include opioids, nsaids, sedatives, antidepressants) 2. intraoperative fentanyl use \> 3 μg/kg 3. patients with definite diagnosis of esophageal reflux syndrome 4. use of sedatives, antiemetics, or antipruritics within 24 hours before operation 5. surgery \> 4 hours or laparoscopy surgery

Keywords: analgeisa postoperatve side effects