Kornimate/medical-research-clean huggingface dataset:
spiritual assessment in chronic pain patients

Conditions: Chronic Pain; Spirituality

Summary: the world health organization's (who) understanding of health(care) is incrementally incorporating the spiritual dimensions equivalent to the physical, psychological and social ones. yet, it remains widely neglected in multi-modal, interprofessional chronic pain therapy. to support gaining access to chronic pain patients' spiritual needs and concerns within therapy, a screening tool has been constructed based on foregoing qualitative research and literature. the screening tool is to be validated with chronic pain patients in clinical settings.

addressing spiritual concerns and needs in chronic pain therapy is in line with the world health organization's (who) understanding of health(care) and would improve health care for this patient group. an applicable screening tool for chronic pain patients' spiritual concerns and needs must be empirically based. based on preceding focus group interviews with patients and with health care professionals in various clinical settings and literature analysis, a screening tool has been constructed. this tool aims at supporting health care professionals as well as chronic pain patients in gaining access to spiritual concerns and needs for incorporation in multi-modal, interprofessional pain therapy. in this project the screening tools' psychometric properties will be tested with in five distinct clinical in- and out-patient settings.

Eligibility criteria:
inclusion criteria: * sufficient command of german language as assessed by local study coordinator * confirmed medical and/or nursing diagnosis of chronic pain * suffering pain for ≥ 6 months * pain intensity was≥ 5 on a 11-point numeric rating scale (nrs; 0 = no pain, 10 = worst pain imaginable) during the last episode of pain exclusion criteria: * life threatening diagnosis (e.g. cancer) that would introduce end-of-life topics as primary aspect * cognitive disorders that would impair participation
a comparative study of high and low tidal volume in preventing hypoxemia in patients with mechanical ventilation after cervical spinal cord injury

Conditions: Cervical Spinal Cord Injury

Summary: this study in order to best tidal volume mechanical ventilation in patients with cervical spinal cord injury (sci) as the research point, through higher low volume settings to find the difference of two groups of patients to prevent the incidence of hypoxemia, to find suitable settings, tidal volume in patients with lower mechanical ventilation in patients with cervical spinal cord injury (sci) the incidence of pulmonary complications, live less intensive care unit (icu).


Eligibility criteria:
inclusion criteria: * all critically ill adult patients with cervical spinal cord injury who require mechanical ventilation and informed consent to be admitted to the department of critical care medicine of peking university third hospital were selected by the subjects or their close relatives to enter the clinical study. exclusion criteria: * previous chronic obstructive pulmonary disease, diagnosis of acute respiratory distress syndrome at admission, presence of pneumothorax at admission, subjects or close relatives who refused to participate in the study, and non-signed informed consent."
indirect ultrasonographic findings for parametrial involvement in deep endometriosis

Conditions: Endometriosis; Deep Endometriosis

Summary: this study evaluated the use of ultrasonographic findings as a first-line imaging tool to raise indirect suspicion of parametrial involvement in women suspected of having severe endometriosis (de).

ultrasonographic findings will be conventionally divided in: * concomitant de nodules * indirect de signs

Eligibility criteria:
inclusion criteria: * patients with suspected deep endometriosis undergoing surgical approach exclusion criteria: * patients with a previous surgical diagnosis of endometriosis * pazients with radiological evidence of parametrial endometriosis * patients who could not undergo transvaginal and/or transabdominal ultrasound for any technical reason

Keywords: parametrial endometriosis deep endometriosis transvaginal ultrasound
comparison of robot assisted thoracic surgery with video assisted thoracic surgery in case of lung cancer

Conditions: Lung Cancer; Postoperative Pain; Blood Loss; Inflammatory Response

Summary: in this study the investigator will compare the effectiveness of robot assisted thoracic surgery (rats) with video assisted thoracic surgery (vats) in case of lung cancer. the perioperative circumstances and postoperative outcome will be compared.

participants are randomly subdivided (1:1) to either undergo robot assisted lobectomy or video assisted thoracoscopic lobectomy in case of lung cancer. at the end of both surgical interventions the anaesthesiologist administers the same technique of pain relief: paravertebral blockage. the data that are going to be investigated are: operative time, conversion to spreading of the ribs/thoracotomy, blood loss, lymph node dissection, prolonged air leak, chest tube drainage, length of stay, inflammatory reaction (through inflammatory parameters crp, il-3, il-6, tnf), lung recuperation (through a lung function test) and postoperative pain (vas score questionnaire).

Eligibility criteria:
inclusion criteria: * patients must be 18 years old or older * patients can be male or female * patients with a lung tumour which is treatable with surgery exclusion criteria: * pregnancy * inoperable lung tumour * patients which are at risk for general anaesthesia

Keywords: thoracoscopic surgery rats vats robot
preference of genetic polymorphism and pharmacokinetics

Conditions: HIV

Summary: genetic polymorphism affects plasma concentration of antiretroviral therapy in hiv patients. the investigators investigate the prevalence of genetic polymorphism affecting efavirenz metabolism and the corresponding pharmacokinetics of different genotypes.

eligible patients are invited to donate blood samples for pharmacokinetic study and genotype analysis

Eligibility criteria:
inclusion criteria: * southern chinese hiv patients on efavirenz exclusion criteria: * refuse to sign consent, hiv patients not on efavirenz

Keywords: hiv
induction chemotherapy with nab-paclitaxel, cisplatin and fluorouracil for locoregionally advanced nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma; Nasopharyngeal Cancer; Nasopharynx Cancer

Summary: nasopharyngeal carcinoma (npc) is commonly observed in southern china, particularly in the pearl river delta area and the xijiang river basin in the guangdong and guangxi provinces, with an incidence rate as high as 25-50 per 100,000. the national comprehensive cancer network guidelines (version 1, 2018), have recommended use of induction chemotherapy followed by ccrt as category 2a for npc, especially the tpf regimen as category 1 for ebv-associated disease. the nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is a promising new agent with more efficient entry to the tumor microenvironment and preferential uptake by cancer cells. superior activity of nab-paclitaxel regimens without the necessity for antianaphylactic pretreatments has been shown in various solid tumors compared with the traditional solvent-based paclitaxel-based ones. however, the safety and efficacy of combination of nab-paclitaxel, cisplatin and fluorouracil (apf) has not been determined in patients with locoregionally advanced npc. in this prospective, multi-centeric, open, non-controlled phase ii clinical trial, investigators perform an exploratory study to the efficacy and safety of apf.


Eligibility criteria:
inclusion criteria: 1. patients with newly histologically confirmed non-keratinizing (according to world health organization (who) histologically type). 2. tumor staged as t3-4/n1-3 (according to the 8th uicc edition). 3. no evidence of distant metastasis (m0). 4. ebv positive. 5. satisfactory performance status: ecog≤2. 6. adequate marrow: leucocyte count ≥4000/ul, hemoglobin ≥90g/l and platelet count ≥100000/μl. 7. normal liver function test: alanine aminotransferase (alt)、aspartate aminotransferase (ast) \<1.5×upper limit of normal (uln) concomitant with alkaline phosphatase (alp) ≤2.5×uln, and bilirubin ≤uln. 8. adequate renal function: creatinine clearance ≥60 ml/min. 9. patients must be informed of the investigational nature of this study and give written informed consent. exclusion criteria: 1. who type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma. 2. age\>60 years or \<18 years. 3. treatment with palliative intent. 4. prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer. 5. pregnancy or lactation. 6. history of previous radiotherapy (except for non-melanomatous skin cancers outside intended rt treatment volume). 7. prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes. 8. any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose \>1.5×uln), and emotional disturbance.
metformin glycinate on metabolic control and inflammatory mediators in type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the aim of this study is to compare the efficacy and safety of metformin glycinate versus metformin hydrochloride in metabolic control and inflammatory mediators in mexican type 2 diabetes patients, in a 12 months follow up.

metformin glycinate salt is a new drug , which has better pharmacokinetic characteristics (better bioavailability and absorption) making a proper antihyperglycemic power without increasing the frequency of adverse effects. the drug has been tested in preclinical test with animals, in healthy subjects and in patients with type 2 diabetes; which showed that it has adequate antihyperglycemic effect. now, its important to compare metformin glycinate and metformin hydrochloride for evaluate the relative antihyperglicemic power. in addition, a study with a larger number of patients improve the statistical power of the test to investigate the effects of these drugs on possible weight loss and lipid profile improve. additionally, it will also explore the relative power of the two medications tested to modify inflammatory response mediators and oxidative stress have been associated with the incidence of cardiovascular disease in diabetes. this project was designed with the intent to answer the next question: what are the efficacy and safety of metformin glycinate dose of 2101.2 mg/day (equivalent to 1700 mg/day metformin hydrochloride), compared with metformin hydrochloride in doses of 1700 mg/day for 12 months of treatment in patients with type 2 diabetes.

Eligibility criteria:
inclusion criteria: * type 2 diabetes according ada * less than a year of evolution since diagnosis * without antihyperglycemic pharmacological treatment * hba1c between 6.5% and 9.5% * stable weight during the last 6 months * body mass index ≥ 25 kg/m2 and \<35kg/m2. * blood pressure ≤ 130/80 mmhg * childbearing women under contraceptive treatment * signed informed consent form * age from 18 to 70 years old exclusion criteria: * non-fulfilment treatment in the screening period * smoking up to 1 year before the initial examination * drugs or alcohol abuse * creatinine depuration estimated with mdrd formula using serum creatinine \< 90 ml/min/1.72m2 * history of chronic liver disease, alt or ast ≥ 2 times from the normal superior limit, or ggt ≥ 3 times from the normal superior limit. * chronic lung disease, that causes dyspnea equivalent to a functional class ≥3 (nyha)or that requires oxygen supplementation. * history or symptoms of coronary artery disease (cad) or cerebrovascular disease (cvd). * drug treatment that interact with biguanides. * another chronic diseases that restricts survival or associated with chronic inflammation like: cancer, leukemia, lymphoma, erythematosus lupus, asthma, rheumatoid arthritis or infection for hiv. * pregnancy or positive pregnancy test in women under 50 years old or breastfeeding.

Keywords: type 2 diabetes metformin glycinate metabolic control
treament of rumination

Conditions: Rumination Disorders

Summary: background. rumination syndrome is characterized by effortless recurrent regurgitation of recently ingested food into the mouth, with consequent expulsion or re-chewing and swallowing. in a previous study we showed that rumination is produced by an unperceived, somatic response to food ingestion. we developed an original biofeedback technique based on electromyography-guided control of abdominothoracic muscular activity. in a randomized, placebo-controlled trial we demonstrated the superiority of biofeedback over placebo for the treatment of rumination. however, the technique is technically complex and unpractical. aim. to prove the efficacy of a simplified biofeedback technique for the treatment of rumination. selection criteria. rumination after meal ingestion. intervention. patients will be randomized into biofeedback in placebo groups. three sessions of either biofeedback or placebo intervention will be performed after ingestion of a probe meal during the first 3 weeks of the 4 weeks intervention period. biofeedback: patients will be taught to control abdominal and thoracic muscular activity by providing a visual display of the abdominal and thoracic perimeter; patients will be instructed to perform the same exercises before and after breakfast, lunch and dinner during the 4-week intervention period. placebo: abdominal and thoracic perimeter will be recorded but not shown to the patient and a pill of placebo containing 0.5 g glucose will be administered; patients will be instructed to take a pill of placebo before breakfast, lunch and dinner during the 4-week intervention period. primary outcome measure: number of rumination events measured by electromyography in response to the challenge meal before and after treatment. secondary outcome measures: * number of self perceived rumination events measured by questionnaires administered daily for 10 days will before and after treatment. * associated abdominal symptom measured by questionnaires administered daily for 10 days before and after treatment. * follow up: number of self perceived rumination events measured at 1, 3 and 6 months after treatment.


Eligibility criteria:
inclusion criteria: * rumination syndrome exclusion criteria: * relevant organic diseases
association of near infrared spectroscopy with interstage outcomes

Conditions: Single-ventricle

Summary: the purpose of this study is to assess the utility of renal near infrared spectroscopy in the outpatient setting during the interstage period. the primary aim will be to determine the correlation between oxygen extraction ratio ((arterial pulse oximetry - renal near infrared spectroscopy value)/arterial pulse oximetry value) with need for inpatient admission or intervention. secondary aims will be to determine the correlation of the oxygen extraction ratio with weight gain, neurodevelopment, unexpected admissions, systemic ventricular strain by echocardiography, and glenn hospitalization admission characteristics.

as above

Eligibility criteria:
inclusion criteria: * infants under 6 months of age * infants with single ventricle heart disease and parallel circulation * infants who are awaiting the glenn operation * infants who are outpatient exclusion criteria: * infants over 6 months of age * inpatients * infants with history of skin injury from the near infrared spectroscopy sensor inpatient * infants with ongoing hyperbilirubinemia
plating versus nailing in pediatric bb forearm fractures

Conditions: Intramedullary Nail; Plate Fixation; Forearm Fracture; Randomized Controlled Trial

Summary: a randomized controlled trial to compare between dual intramedullary nailing and dual plating trying to synthesis a high quality evidence study that can solve the conflict between the decisions.


Eligibility criteria:
inclusion criteria: 1. both-bone forearm diaphyseal fracture. 2. age more than or equal nine years old with open distal radius physis. 3. simple transverse or short oblique fractures (2r2-a2,2r2-a3,2u2-a2,2u2-a3) according to ota/ ao classification. exclusion criteria: 1. neurovascular injury. 2. open fractures 3. comminuted fractures 4. pathological fractures

Keywords: forearm fractures pediatric fractures flexible nail plate fixation
animated picture to improve provider adherence to ct scan for head injury rule

Conditions: Minor Head Injury

Summary: it is difficult for pediatric emergency department providers to recognize clinically significant head injuries that are likely to require neurosurgical intervention or close monitoring from those that can be safely discharged. research question how do a combination of education and an animated picture depicting the pecarn ct head injury rules impact compliance to these rules and reduce unnecessary head ct scans? design this is a within subject, repeated measures study design.


Eligibility criteria:
inclusion criteria: * patients presenting to children's ed will be included if they: * are between 0 and 18 years of age (inclusive) * receive a discharge diagnosis of head injury * present to the ed within 24 hours of the head injury * gcs of 14 or greater exclusion criteria: * patients will be excluded if they : * had a ct scans done in an outside transferring institution * have obvious penetrating head injuries * had a trivial injury mechanisms such as ground-level falls or walking or running into stationary objects * have no signs or symptoms of head trauma other than scalp abrasions and lacerations. * have known brain tumors, pre-existing neurological disorders complicating assessment, ventricular shunts, bleeding disorders

Keywords: head injury ct emergency radiation
minimally invasive control of epistaxis (mice)

Conditions: Epistaxis

Summary: epistaxis is a common disorder with 60% of the population suffering from one episode and 10% of these cases requiring medical attention. between march 2006 and march 2007, in calgary, alberta, there were 1500 presentations of epistaxis to adult emergency rooms with 7% of these (105 patients) requiring packing with admission. common methods to control epistaxis include, nasal packing (88%), operative arterial ligation (10%), and arterial embolization (2%). a cost analysis demonstrated that nasal packing had a lower cost compared to embolization and arterial ligation, and all modalities had similar lengths of stay (goddard, otolaryng head neck surg. 2006). arterial ligation is the current recommended therapy for recurrent or refractory epistaxis, with a success rate of 98%. with the advancement of endoscopic techniques, emergency room minimally invasive control of epistaxis (m.i.c.e.) allows for selective packing and cauterization, which provides the patient with retained function of their nasal cavity and prevents a hospital admission, resulting in significant cost savings. hypothesis: does the m.i.c.e. procedure provide significant cost savings compared to operative sphenopalatine artery ligation? null hypothesis is that there is no difference in hospital admission rates between m.i.c.e. and operative sphenopalatine artery ligation.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old, presenting to rockyview general hospital emergency room * no coagulopathy (must have inr reversed before inclusion) * available for follow-up at 1 week and 1 month in calgary, alberta * refractory or recurrent epistaxis defined as: * refractory = unable to control epistaxis with bilateral merocel™ nasal tampons fully inserted into nasal cavity * recurrent = epistaxis after removal of merocel™ nasal tampons following outpatient packing for 48 hours exclusion criteria: * uncorrectable coagulopathy * unable to comply with procedure * pregnancy * non-calgary emergency room presentation * severe posterior epistaxis requiring intubation for airway protection

Keywords: epistaxis epistaxis refractory to emergency physician treatment
davitri: semi-automated vitrificacion clinical study

Conditions: Fertility Issues

Summary: the main objective of this clinical study is to demonstrate the non-inferiority of the semi automated device (davitri) developed by overture life in the preparation procedures for vitrification of human samples.

vitrification is a manual technique that is routinely used in assisted reproduction clinics for the cryopreservation of oocytes and embryos in liquid nitrogen at -196oc. there are different methods of vitrification, the most used being the cryotop of kitazato. this is a manual process that requires precision and experience to achieve a good result. for this reason, the correct execution of the technique is considered key in in vitro fertilization (ivf) treatments, as it can favor the preservation of fertility and optimize clinical results. the purpose of the study is to validate the viability of the semi automated vitrification process, to obtain survival rates similar to or superior to manual processes, and also the capacity to provide greater reproducibility in the results. the semi automatic exchange of vitrification fluids in human oocytes is as efficient as the manual procedure, in terms of survival (85-90%), but with significantly lower variability between technicians and between centers (95% reproducibility), as well as reduced manual processing times. the initial hypothesis is that semi automated vitrification equals or improves the manual technique, thus introducing a new standardized protocol for clinical use.

Eligibility criteria:
inclusion criteria: * donors will be selected according to the clinic's usual inclusion criteria in terms of infectious diseases, genetic diseases, karyotype, etc. exclusion criteria: * bmi\ 25 * implantation failure * abnormal ovulation cycle * endometrial thickness \> 7mm

Keywords: vitrification
analysis of the fixation of the proximal biceps tendon

Conditions: Disorder of Tendon of Biceps

Summary: ten randomly selected patients that have undergone an open proximal biceps tendon tenodesis with an endobutton for bicipital pathology with christopher schmidt, md, will be asked to participate in the study. the study will assess the tendon healing to bone through magnetic resonance imaging (mri). individuals will also be asked to fill a visual analog scale (vas) pain and disability of the arm shoulder and hand (dash) assessment tools. the variables for our objective will include age, hand dominance, gender and chronicity of symptoms prior to surgery, and other related surgical procedures.


Eligibility criteria:
inclusion criteria: * undergone open subpectoral proximal biceps tenodesis with the endobutton exclusion criteria: * no history of surgery or disability in the contra-lateral extremity * not a member of a legally restricted group or protected population * no prior surgery or further surgery on the extremity of interest * no condition preventing the individual from undergoing a mri

Keywords: proximal biceps pathology