Kornimate/medical-research-clean huggingface dataset:
serum ctrp3 and rbp4 levels in obesity and hypertension

Conditions: Obesity; Hypertension

Summary: insulin resistance is closely correlated with obesity and cardiovascular disease. adipokines may play important roles in the pathogenesis of obesity, which are a link between obesity and obesity-related disorders.c1q/tnf-related protein-3 (ctrp3) and retinol-binding protein 4 (rbp4) are novel adipokine that modulates the action of insulin in various diseases. this study addressed the relationship between ctrp3, rbp4 and ir in newly diagnosed obesity and essential hypertension.

serum ctrp3 and rbp4, anthropometric and metabolic parameters were determined in 480 newly diagnosed obesity and essential hypertensive patients not taking anti-obese and antihypertensive medications and 66 normal weight (nw) and normotensive subjects. all subjects were divided into two groups depending on body mass index (bmi), including nw group and obesity group, and then four subgroups were divided according to obesity and hypertension, including nw-normal blood pressure subgroup (nw-nbp), nw-hypertension subgroup (nw-htn), obese-normal blood pressure subgroup (ob-nbp), obese-hypertension subgroup (ob-htn).

Eligibility criteria:
inclusion criteria: 1. hypertension not taking antihypertensive medications 2. obesity not taking anti-obese or lipid-lowering medications exclusion criteria: 1. heart failure; 2. pregnant or lactating 3. diabetes 4. thyroid disease 5. fractures 6. osteoporosis 7. tumors;
efficacy of oral leukotriene in long term therapy of mild and moderate obstructive sleep apnea syndrome in children

Conditions: Obstructive Sleep Apnea Syndrome

Summary: the aim of the project is to evaluate whether therapy with leukotriene may be a valid therapeutic approach in children with adenotonsillar hypertrophy and with mild and moderate obstructive sleep apnea syndrome (osas) and to evaluate whether leukotriene is less, equally or more efficient than nasal steroid.

the aim of the project is to evaluate whether leukotriene is less, equally or more efficient than nasal steroid in children with adenotonsillar hypertrophy and with mild and moderate osas checking if leukotriene administrated for 24 weeks improves overnight oximetry, polysomnography and checking if leukotriene as anti-inflammatory of upper airway really reduces the tonsils and adenoids dimensions.

Eligibility criteria:
inclusion criteria: * diagnosis of mild (rdi 3- \<5) or moderate obstructive apneas (rdi 5-8) by overnight polysomnographic evaluation with 4 channels eeg * adenotonsillar hypertrophy friedman score's ii-iii-iv° exclusion criteria: * neuromuscular, gastrointestinal, neurological diseases and syndromes of malformations * use of leukotrienes and/or nasal and oral steroids in the 4 weeks preceding the initial sleep study * acute upper respiratory tract infections * adenotonsillectomy

Keywords: obstructive sleep apnea syndrome snoring adenotonsillar hypertrophy polysomnography intranasal steroids anti-leukotrienes
longitudinal comparative effectiveness of bipolar disorder therapies

Conditions: Bipolar Disorder

Summary: the objective of this retrospective observational study is to compare commonly prescribed bipolar disorder medications for their impact on: (1) hospitalization; (2) suicide attempts and self-harm; and (3) risk of drug-induced adverse effects such as kidney disease and diabetes mellitus. in addition, the investigators will examine heterogeneity of treatment effect by co-morbidity within pediatric, adult, and elderly sub-populations. patient focus groups are convened to elicit additional questions and provide feedback on results.

funded by pcori, the objective of this retrospective observational study is to perform several safety and effectiveness comparisons on commonly prescribed bipolar disorder medications, engaging patient focus groups in generating additional questions and interpreting results. the study will be a retrospective cohort study conducted with administrative claims data from the truven marketscan commerical claims and encounters and medicare database from 2010-2016. the database contains approximately 140 million patients within the us population in every state and nearly every county in the nation, across all ages, ethnicities and socioeconomic categories, including privately insured, and medicare patients. the study will focus on approximately one million patients with two or more diagnoses of bipolar disorder in the claims records according to icd-9 and/or icd-10 coding. the treatments that will be compared are lithium carbonate; first generation antipsychotics: haloperidol and perphenazine; second generation antipsychotics: clozapine, risperidone, olanzapine, aripiprazole, quetiapine, ziprasidone, asenapine, lurasidone, and paliperidone; mood stabilizing anticonvulsants: valproate, lamotrigine, carbamazepine, and oxcarbazepine; antidepressants: mirtazapine, bupropion, desvenlafaxine, duloxetine, venlafaxine, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, vilazodone, and doxepin. the investigators will perform cross-sectional and survival based analysis using regression, propensity scoring, and local control to perform bias-corrected comparisons of the above treatments for for their impact on: (1) hospitalization; (2) suicide attempts and self-harm; and (3) risk of drug-induced adverse effects such as kidney disease and diabetes mellitus. in addition, the investigators will examine heterogeneity of treatment effect by co-morbidity within pediatric, adult, and elderly sub-populations.

Eligibility criteria:
inclusion criteria: * two or more instances of bipolar disorder diagnoses within administrative claims records exclusion criteria: * patients with less than 1 year of history in the database
effects of abo blood types on the survival and marginal bone resorption of dental implants

Conditions: Implant Tissue Failure

Summary: this study evaluates implant survival and marginal bone resorption in patients receiving implant treatment with respect to demographic data and ab0 (groups) blood types.

for a successful dental implant, optimal soft and hard tissue characteristics are required. these characteristics include appropriate bone quality and a healthy adherent keratinized gingiva that surrounds the implant neck. the most common complications are peri-implant diseases and marginal bone loss for dental implants. marginal bone loss around the implant may be observed as a long-term complication due to microbial dental plaque-induced peri-implant inflammatory disease or may be observed in the absence of such a disease. the immune system and genetic factors are known to have important effects on implant success, and abo blood types are also included in the genetic factors. in the studies evaluating the association of abo blood types with increased susceptibility to infection and various systemic diseases, it was reported that the percentages of blood types differed significantly, especially in skeletal-muscle system injuries, fractures and cardiovascular disease susceptibility. also some researchers reported that blood types may be effective on the bacteria colonization which is the main reason of the periodontal diseases. abo blood types may have an impact on dental implant success and survival.

Eligibility criteria:
inclusion criteria: * the inclusion criteria for the study group included being 18 years of age and non-smoker, not having any systemic disease, not having undergone any hard and soft tissue augmentation during implant surgery, having implants placed at bone level, having received cylindrical form implants with sla surface structure, not missing any follow-up visits after implant surgery evidenced with radiographic recordings, having received flat abutment, having cemented implants, and being rehabilitated with fixed prosthetic restoration. exclusion criteria: * no

Keywords: blood types, dental implant, marginal bone resorption, implant survival
study of ear comfort ear drops to treat aoe cases compared to dexotic & otidin(r)

Conditions: Acute Otitis Externa

Summary: phase ii 3 arm double blinded clinical study, to evaluate pain killing and healing time of botanical ear drops, ear comfort™, in severe external ear infection (aoe) patients in comparison to dex-otic® and otidin®. study outcome (hypothesis): if ear comfort™ proves to perform as well as dex-otic, then ent's and family doctors will have a botanical non-antibiotic product that does not promote the formation of antibiotic-resistant infections and may be given to anti-biotics sensitive patients. ear comfort™ is pharmacologically stable for at least 3 years on the shelves.

severe external ear infection (aoe) also known as swimmer's ear, is an abundant microbiological contamination disease of the outer ear canal. it causes severe pains and accumulation of fluids in the ear. in some cases it may compromise the hearing. swimming in contaminated water or cleaning the ear with a hard subject are only two examples of what may cause aoe. the main pathogenes causing the disease are gram negative of which pseudomonas aeruginosa is the most abundant. occasionally it is a fungoid contamination with aspergillus niger being the most abundant.

Eligibility criteria:
inclusion criteria: * patients with aoe. * aoe patient determined by ear canal obstruction, exudates and pain. * males and females between 18 and 65 years of age. * patients willing to refrain from using any ear drops products for the entire duration of the study. - - subjects are willing to use the full 4 steps protocol * written informed consent has been obtained. exclusion criteria: * known allergy or sensitivity to chamomile extract or essential oils. * injury to tympanic membrane. * medical or psychiatric conditions that affect the patient's ability to give informed consent, or complete the study. * pregnant or lactating females. * use of ear drops or antibiotic or analgesic medications within the last 4 weeks prior to enrolment to the study. * other known diseases, including severe allergy, chronic liver or kidney disease, malignancy or contagious diseases, such as hiv or hepatitis. * alcohol or drug abuse, according to assessment by the investigator. * participation in other clinical trial within the last 30 days.

Keywords: aoe ear comfort dex otic otidin
coaching intervention in women at-risk for common mental disorders

Conditions: Common Mental Disorders

Summary: this study aims to provide coaching intervention for prevention of developing common mental disorders to 60 at-risk women in hong kong.

participants will be recruited through online screening tool. eligible subjects with informed consent provided will be randomly assigned to coaching group or self-help tips plus telephone support group. to test the effectiveness of the coaching intervention, data collection will be conducted on demographics, symptoms and psychosocial aspects at baseline, immediately, 3-month and 12-month post-intervention. a self-reported brief questionnaire will be administered at every intervention as well.

Eligibility criteria:
inclusion criteria: * willing to provide written informed consent * able to understand cantonese and read/write chinese * with subsyndromal or minor common mental disorders (cmd) indicated by 10 - 20 of depression subscale of depression, anxiety and stress scale (dass) or 8-14 of anxiety subscale of dass exclusion criteria: * those mental conditions that require other treatment priorities (e.g., suicidal risk, substance abuse, current or past episodes of psychotic disorder, personality disorders) * those medical conditions that severely limit participation, comprehension, or adherence to treatment (e.g., epilepsy, dementia, terminal medical illness) * those who are receiving structured psychotherapy or counseling
compare the patient satisfaction and effectiveness after novel application-based or conventional health education of bowel preparation for colonoscopy

Conditions: Colo-rectal Cancer; Colon Lesion

Summary: colorectal cancer is the cancer with highest incidence in taiwan. the disease itself and subsequent treatment cause huge impact on the physical, psychological, and spiritual parts and social role of a patient. early diagnosis of colorectal cancer and precancerous lesions is possible. early treatment can reduce the impact on quality of life and economics. colonoscopy is an important tool for diagnosis of colorectal proliferative lesions. qualified bowel preparation can enhance sensitivity and reduce false negative of the colonoscopy. however, multiple factors influence the quality of bowel preparation. this study aims to investigate whether the animation video and game-based health education is more effective and satisfying than conventional health education, and to explore the difference of knowledge dissemination and quality of bowel preparation between novel and conventional methods. this study is a randomized controlled trial and uses structural questionnaire for study participants. before the main study, the investigators will consult professors' opinions to adjust and enhance validity of the questionnaire, and the investigators will perform pretest to calculate its reliability. the investigators will enroll participants at the out-patient-department and the health management center. questionnaires may be completed by on-site paper or phone with internet resources. the main participants of this study are adults aged 18 and more, and planned to receive colonoscopy. the questionnaires investigate the spent time, patient satisfaction, knowledge of bowel preparation and results of colonoscopy of different approaches of health education. multiple linear regression will be applied to calculate the possible significance difference between two kinds of health education. the investigators expect this study (1) to explore whether novel health education enhances patient satisfaction (2) to investigate the efficiency of novel health education, and (3) to compare the effect of knowledge dissemination and quality of bowel preparation between experimental and control groups. this study will develop the model of health education to facilitate holistic health care.


Eligibility criteria:
inclusion criteria: * adults planned to accept colonoscopy exam exclusion criteria: * can't accept health education or refuse follow-up
an open-label extension of bps-mr-pah-201 in pulmonary arterial hypertension (pah) patients

Conditions: Pulmonary Arterial Hypertension

Summary: this is an open-label extension study for patients who participated in the bps-mr-pah-201 study.

this is an open-label study for patients who participated in the bps-mr-pah-201 study and have volunteered to continue treatment for pah with bps-mr tablets. each patient will return to the clinic following enrollment in the study at 3, 6, and 12 months, and annually thereafter for assessment. currently enrolled patients may be invited to participate in an optional four times daily (qid) dosing substudy of bps-mr with total daily dose of bps-mr achieved previously in the main study. patients will return to the clinic for baseline visit, week 12, and then will follow the visit schedule provided to them in bps-mr-pah-202 main study.

Eligibility criteria:
inclusion criteria: * patients who remained on study drug and completed all assessments during the treatment phase of study bps-mr-pah-201 are eligible for this study. * female patients must either be physiologically incapable of childbearing or be practicing an acceptable method of birth control (e.g. approved hormonal contraceptive, barrier method, such as condom or diaphragm, used with a spermicide, or an intrauterine device). exclusion criteria: * patients who discontinued study drug during the previous study (bps-mr-pah-201) for any reason (e.g. treatment related adverse events) are not eligible for entry into this study. * patients who are pregnant or lactating are excluded from participation in the open-label extension.
b-slim, a multi-source digital super coach for sustainable weight loss

Conditions: Obesity

Summary: the purpose of this study is to carry out a field trial to evaluate the effectiveness and added value of the b-slim digital super coach in a convenient sample of overweight and obese adults.

the purpose of this study is to carry out a field trial to evaluate the effectiveness of the b-slim digital super coach in a convenient sample of overweight and obese adults. the effectiveness will be evaluated at the individual level by means of a randomized trial. by combining or not combining the use of the b-slim digital super coach with a conventional physical activity and nutrition coaching, the effectiveness of the super coach of the (user-driven) 'super coach' compared to a conventional face to face weight loss program can be determined. outcomes will be measured at the level of health behavior (i.e., physical activity and nutrition), body composition, physical fitness, psychosocial factors (e.g., motivation) and program adherence. the field trial will take place in leuven (belgium). this study can be seen as a pilot trial. the central hypothesis of this field trial is that using the multi-source b-slim digital super coach will support and assist overweight and obese adults to change their health behavior (i.e., physical activity and nutrition) and to lose body weight by improving their self-control, self-determined motivation and attitude towards regular physical activity and healthy diet. the investigators will check if the super coach can be a valuable alternative for a conventional physical activity and nutrition coaching.

Eligibility criteria:
inclusion criteria: * living in the region of leuven * middle-aged (from 18 to 65 years) * having a body mass index between 29-34 kg/m² * having an e-mail address * having a personal computer exclusion criteria: * suffering from a known physical (e.g., orthopedic limitations, stroke, etc.) and/or psychological (e.g., anorexia, bulimia, depression, etc.) disease or co-morbidity * intake of any medication with possible impact on body weight, endurance capacity * currently treated for diabetes (both type 1 \& 2). * no sleepapneu has been determined during the last year. * having a history of systematic strength or endurance training (moderate to high intensity training more than once a week) in the year before the beginning of the trial * having a history of following a supervised dietary advice in the year before the beginning of the trial * having a history of bariatric surgery or any other malabsorption-related disease. * pregnancy

Keywords: digital coaching sustainable weight loss self-determination theory obesity overweight diet physical activity
loss of effect of aspirin on platelet aggregation during chronic administration

Conditions: Platelet Aggregation

Summary: aspirin has shown to be beneficial to some patients with certain diseases such as coronary artery disease or stroke. we are investigating how aspirin works on regulating platelets and thromboxane over time at different doses. we hope to find the best dose of aspirin and/or other medications to help people who are at risk for heart attack or stroke.

he purpose of the study is to better understand the mechanism for failure of daily aspirin administration to prevent cardiovascular events in some at risk individuals. we seek to describe the effect of chronic aspirin administration at varying doses on platelet aggregation. this will help to define mechanisms for aspirin failure and to pursue possible alternative therapies in patients who fail to respond to aspirin therapy. we hypothesize that (1) inhibition by aspirin (asa) of ex vivo-induced platelet aggregation varies in a predictable time and dose dependent manner, (2) thromboxane and prostacyclin production is inhibited by asa in a dose-dependent manner and remains relatively constant over time once maximal inhibition has occurred, and (3) granule secretion by platelets during induced aggregation is inhibited by aspirin acutely but this effect does not persist during chronic administration at high doses.

Eligibility criteria:
inclusion criteria: * males * age 18-40 years * non-smokers exclusion criteria: * asa/nsaid use previous 14 days. * evidence of asa/nsaid use within previous 14 days at baseline visit based on investigator interpretation of platelet aggregation and platelet secretion studies. * history of chronic nsaid use. * currently taking nsaids, corticosteroids, or anticoagulants. * history of coronary artery disease, myocardial infarction, coronary artery bypass grafting, percutaneous angioplasty, diabetes mellitus or stroke. * history of gastric,duodenal, or esophageal ulcers or serious gastrointestinal bleed. * history of frequent headaches, pain syndrome, or other condition requiring frequent use of analgesics. * history of adverse reaction to asa. * initial platelet count \ 500k/µl. * initial hematocrit \ 50%. * weight less than 110 pounds.

Keywords: platelet aggregation granule secretion thromboxane production prostacyclin production
local anesthesia with needle-free injection system

Conditions: Pediatric Anesthesia; Local Anesthesia

Summary: the purpose of this study was to compare the pain during needle insertion and injection in mandibular molars anesthetized with either traditional syringe (control) or comfort in system (experimental).


Eligibility criteria:
inclusion criteria: * in need of treatment of right and left molar teeth of mandible, * does not have any systemic disorder, * high level of communication that can provide logical answers to the questions we ask * with parental consent, * volunteers who want to participate in the research * 6-12 years old patients who are compatible with routine dental treatments in the pediatric clinic exclusion criteria: * no need for treatment of right and left molar teeth of mandible, * has a systemic condition * low level of communication that cannot provide reasonable answers to the questions we ask * without parental consent * do not want to participate voluntarily in the research * do not attend a check-in * patients not in the 6-12 age group

Keywords: needle-free injection pain
prospective dengue seroprevalence study in 5 to 10 year-old children

Conditions: Dengue; Dengue Fever; Dengue Hemorrhagic Fever

Summary: this is a descriptive prospective community-based seroprevalence study. primary objective: * to determine the prevalence of specific antibodies (immunoglobulin g \[igg\]) against dengue in healthy 5 to 10 year-old children in india. secondary objectives: * to determine the dengue virus serotype (denv-1,2,3 and /or 4) specific to the antibodies in positive (igg) samples * to estimate the prevalence of specific antibodies (igg) against japanese encephalitis in healthy 5 to 10 year-old children in india.


Eligibility criteria:
inclusion criteria: * aged between 5 and 10 year-old on the day of inclusion * healthy child as reported by the parent or legally qualified guardian * being registered in selected study site * provision of the informed consent form signed by at least one parent or legally qualified guardian * for children between 8 and 10 years old, provision of the assent form signed. exclusion criteria: * n/a

Keywords: dengue dengue fever dengue hemorrhagic fever