Kornimate/medical-research-clean huggingface dataset:
personalized obstructive sleep apnea treatment and effects on alzheimer's disease biomarkers and cognition among blacks

Conditions: Sleep Apnea

Summary: the purpose of this research is to see how effective the personalized obstructive sleep apnea (osa) treatment adherence model called praise is in helping the patient stick to the physician recommended osa treatment plan positive airway pressure (pap).


Eligibility criteria:
inclusion criteria: * self-reported race/ethnicity as african american, african, caribbean or black * ages 60-85 years * accessible by phone * osa diagnosis * consent, including permission to release medical data exclusion criteria: * progressive illnesses in which disability or death is expected within 1 year * impaired cognitive/ functional ability precluding participation * intention to move within the year * and a family member currently enrolled.
comparing different methods for collection of comorbidity data per the hct-ci

Conditions: Hematopoietic Malignancy

Summary: comorbidity assessment in the field of hct might be a burden on the medical team at the clinic or the research staff. this research study aims to explore and validate new methods, claims-based and patient questionnaire-based, as alternatives to the standard chart-based method in order to facilitate comorbidity coding. the study aims to save time and effort of medical personnel and to ensure the inclusion of comorbidity information in all clinical trials and outcome research studies in order to improve the accuracy of treatment decision-making, patient assignment to appropriate hct strategy and hence hct outcomes.

studies have shown the importance of pre-transplant comorbidities in predicting mortality after allogeneic hct. however, comorbidity assessment might be a burden on the medical team at the clinic or the research staff. this research study aims to explore and validate new methods as alternatives to the standard chart-based method in order to facilitate comorbidity coding. the study aims to save time and effort of medical personnel and to ensure the inclusion of comorbidity information in all clinical trials and outcome research studies in order to improve the accuracy of treatment decision-making, patient assignment to appropriate hct strategy and hence hct outcomes. this study will investigate two parallel approaches aimed at simplifying comorbidity assessment and thereby facilitating wide-spread use of the hct-ci. patient questionnaire-based and claims-based methods will be tested as possible alternative to the chart-based method. primary outcome is prediction of non-relapse mortality. it is expected that once this method of comorbidity coding is validated, it will benefit physicians in non-academic institutions and community clinics.

Eligibility criteria:
inclusion criteria: * patients eligible for autologous or allogeneic hct. * able to speak and read english. * willing and able to provide informed consent. * there is no restriction based on diagnosis, intensity of conditioning regimen, type of donor graft, degree of hla-matching, or stem cell source. * patients \>20 years old * access to a telephone for study-related communications. exclusion criteria: * hct candidates who cannot read, write, or speak english. * patients \<20 years old

Keywords: hematopoietic stem cell transplantation
curcumin in pediatric inflammatory bowel disease

Conditions: Inflammatory Bowel Disease; Ulcerative Colitis; Crohn's Disease

Summary: this is a single center, open label forced dose titration study designed to determine the tolerability of curcumin in pediatric patients with inflammatory bowel disease (ibd). this study will provide initial tolerability and safety data in pediatric patients with ibd. twenty patients with ibd in remission or with mild disease (score \<34 on pucai or score \<30 on the pcdai) on sulfasalazine or mesalamine aged 8 to 18 years will be enrolled into this study. each patient will participate in the study for nine weeks. from this study an appropriate dosage will be determined to proceed with a double blinded placebo controlled study.


Eligibility criteria:
inclusion criteria: * children and adolescents eight to eighteen years old * diagnosis of inflammatory bowel disease (ibd) made by a pediatric gastroenterologist based upon history, physical examination, laboratory/radiological studies and gastrointestinal histology * mild disease or in clinical remission based upon pucai or pcdai score (score \<34 on the pucai or score \<30 on the pcdai) * parent/guardian and participant must be able to attend study visits at screening, baseline, and weeks three, six, and nine * patient must be on a stable dose of ibd medications for at least 3 months * patient must be able to swallow study medication exclusion criteria: * abnormal laboratory values as defined in the protocol * history of increased gastrointestinal symptoms ("flare") in the last 3 months * current use (past use of these medications is not an exclusion) of medications such as azathioprine, methotrexate or 6-mercaptopurine used to treat ibd * current use (past use of these medications is not an exclusion) of medications or over-the-counter treatments including but not limited to aspirin, nsaid, botanical treatments (ginger, feverfew, yellow clover, salix species, populus species, betula species, and gaultheria species), essential fatty acids (flax oil and fish oil). allowed supplementation includes multivitamin, vitamin d \& calcium, folate and vitamin b12, and iron. * other serious medical conditions such as neurological, liver, kidney, auto- immune or systemic disease. * history of gastrointestinal surgery or planned gastrointestinal surgery in the future. * tobacco, alcohol, or illicit drug abuse * planned surgery during the potential study participation time * inability to swallow study medication

Keywords: crohn's disease ulcerative colitis curcumin pediatric inflammatory bowel disease
d-cycloserine augmentation of exposure and response prevention treatment for obsessive-compulsive disorder

Conditions: Obsessive Compulsive Disorder

Summary: we propose to undertake an initial study of dcs to determine whether it has any short-term clinical benefits when added to standard erp therapy in adults with ocd.

exposure and response prevention (erp) has proven efficacy for ocd treatment in adults. yet, erp does not help all individuals, and those who benefit often remain somewhat symptomatic. behavioral models for ocd treatment are based on two components. first, fears are acquired by the development of an association between a neutral stimulus and an aversive stimulus such the former acquires the aversive properties of the latter. the neutral stimulus is then designated as a conditioned stimulus (cs), and the original aversive stimulus is called an unconditioned stimulus (ucs). second, the acquired fears can be unlearned through presentation of the cs in the absence of the ucs, a process known as extinction. on a neural level, erp incorporates similar mechanisms to those involved in fear conditioning. antagonists at the glutamatergic nmda receptor, which is involved in learning and memory, block both fear learning and extinction. d-cycloserine (dcs), a partial agonist at the n-methyl-d-aspartate (nmda) glutamate receptor subtype, augments learning in animals and humans. clinical application in animals and humans suggest that dcs facilitates the fear extinction process when taken prior to exposure to feared stimuli. an initial trial in acrophobic adults provided support for acute dcs dosing as facilitating extinction to fear. given that erp is based on extinction, it follows that dcs may augment erp therapy providing enhanced treatment effects. with this in mind, we propose to undertake an initial study of dcs to determine whether it has any short-term clinical benefits when added to standard erp therapy in adults with ocd.

Eligibility criteria:
inclusion criteria: 1. a principal diagnosis of ocd assigned at pre-treatment, derived from the adis-iv, with a clinical severity rating of 4 or above; 2. 18-65 years of age; and, 3. an iq of ³ 80. exclusion criteria: 1. positive diagnosis of schizophrenia, other psychotic disorder, pervasive developmental disorder, organic brain syndrome, or mental retardation; 2. do not speak english; 3. are unwilling to attend twice weekly sessions; or, 4. is pregnant, breast feeding a child, or attempting to become pregnant (see below rationale)
olive oil with omega 3 to treat stasis dermatitis

Conditions: Dermatitis

Summary: olive oil and omega 3 have many anti inflammatory effects that may be beneficial in the inflammation and edema of chronic stasis dermatitis. the olive oil contains many mono unsaturated fatty acids and anti oxidants that may add to the well being of a diseased skin by improving cell membrane homeostasis.

patients with chronic stasis dermatitis due to venous insufficiency will be treated with the study cream and as control we will use "venoroutone" . patients will be followed weekly at the clinic of the vascular surgery at assaf harofeh mc.

Eligibility criteria:
inclusion criteria: * patints with stasis dermatitis for 6 months at least exclusion criteria: * skin ulceration or infection

Keywords: olive oil stasis dermatitis patients with stasis dermatitis for at least six months.
scalpel versus diathermy for transverse abdominal incision in first elective caesarean section

Conditions: Cesarean Section; Intraoperative Blood Loss; Postoperative Pain; Wound Heal

Summary: the objective of this study will be to compare two methods of skin incisions during the first caesarean section (cs), that is scalpel and diathermy, assessing differences in blood loss during incision, incisional time, total surgery time, post-operative pain, wound healing, complications, and cosmetic outcomes.

the scalpel has been historically used as the primary cutting tool during caesarean section (cs). however, advancements in surgical devices have introduced alternatives, such as the option to make a diathermic cut using electrosurgical units. general surgeons have extensively demonstrated the advantages of diathermy over the scalpel for abdominal wall incisions, including faster opening time, reduced incisional blood loss, decreased post-operative pain, and a comparable wound complication rate. in obstetrics, there is a scarcity of evidence in this regard, and no consensus or guidelines have been established regarding the optimal method for making a transverse abdominal incision during the first elective cs. currently, the choice between using a scalpel or diathermy remains at discretion of the obstetric surgeon. the objective of this study will be to compare both methods of skin incisions during the first cs, assessing differences in blood loss during incision, incisional time, total surgery time, post-operative pain, wound healing, complications, and cosmetic outcomes.

Eligibility criteria:
inclusion criteria: 1. women without a history of previous cesarean section or other abdominal surgery 2. age greater then 18 years (only adult patients) 3. body mass index (bmi) between 18.5 and 29.9 kg/m2 4. gestational age greater then 37 weeks (at term pregnancies) 5. no contraindications to spinal anesthesia 6. indication to elective cs: extra-obstetrical reasons, failure of medical induction of labor, breech fetal presentation 7. informed consent exclusion criteria: 1. women refusing to participate in the study 2. women undergoing urgency or emergency cesarean deliveries 3. women with a history of previous cesarean section or abdominal surgery 4. women with multifetal pregnancies 5. necessity of general anesthesia 6. use of anticoagulants 7. patients needing a median longitudinal abdominal section 8. patients with pacemakers 9. allergy to cephalosporins 10. any medical disorder that can affect wound healing as diabetes, hypertension, hepatic or renal diseases, chronic anemia, chronic skin conditions, congenital or acquired bleeding diathesis.
special drug use investigation for paxil tablet (20mg-clinical symptom progression)

Conditions: Mental Disorders

Summary: overall improvement, severities and changes of specific clinical symptoms were surveyed in outpatients with depression or in a depressed state to evaluate the efficacy and safety of paxil tablets in patients in whom the paxil dose was increased and those treated with a constant dose.


Eligibility criteria:
inclusion criteria: * subjects who is 18 years or more * subjects diagnosed with depression or in a depressed state exclusion criteria: * subjects who have been treated with paroxetine prior to this investigation * subjects with hypersensitivity to paroxetine * subjects taking monoamine oxidase inhibitors (maois) or within 2 weeks of stopping treatment with maois * concomitant use in subjects taking pimozide
hirudin plus aspirin in the secondary prevention of cardioembolic stroke due to nonvalvular atrial fibrillation

Conditions: Cardioembolic Stroke; Atrial Fibrillation

Summary: to investigate the efficacy and safety of hirudin plus aspirin therapy compared with warfarin in the secondary prevention of cardioembolic stroke due to nonvalvular atrial fibrillation.

for the patients with cardioembolic stroke due to atrial fibrillation,guidelines recommended warfarin as the secondary prevention therapy. but warfarin has its disadvantages such as risk of bleeding and the requirement of frequent inr monitoring. the underuse of warfarin is a prominent problem in china. in our study, patients with cardioembolic stroke were treated with hirudin plus aspirin or warfarin. the aim of our study was to compare efficacy and safety of hirudin plus aspirin and warfarin in secondary prevention of cardioembolic stroke due to nonvalvular atrial fibrillation.

Eligibility criteria:
inclusion criteria: 1. age of 18 or older with nvaf-related cardioembolic stroke 2. diagnosis of cardioembolic stroke conformed to the toast (trial of org 10172 in acute stroke treatment) classification system in terms of the typical clinical presentation, neuroimaging profile, and vascular and cardiac evaluation 3. patients who were after 14 days of stroke onset and with stable clinical status. exclusion criteria: 1. patients with rheumatic heart disease or history of heart valve surgery; 2. patients with acute coronary syndrome or percutaneous coronary intervention within 30 days previous to enrollment; 3. patients with active infective endocarditis; 4. patients with purpura disease or blood coagulation disorder; 5. patients who had active bleeding or the tendency to bleed; 6. patients with history of intracranial hemorrhage (ich) or other serious bleeding events; 7. patients diagnosed with peptic ulcer disease within 30 days previous to enrollment; 8. patients who had esophageal varices; 9. patients who had trauma or major surgery within 30 days previous to enrollment or patients who planned to have major surgery; 10. patients with persistent blood pressure of 180/100mmhg or greater with or without anti-hypertension treatment; 11. patients who need chronic anticoagulant treatment due to disorders other than af; 12. patients with severe liver and kidney dysfunction; 13. patients who were allergic to warfarin, aspirin or hirudin; 14. female patients who are pregnant or lactating.

Keywords: atrial fibrillation cardioembolic stroke hirudin aspirin warfarin
effect of auditory distractions on pediatric postoperative pain

Conditions: Pain, Postoperative

Summary: the aim of the study was to determine the effect of different auditorial methods of attention distraction on postoperative pain and anxiety in children. three group pre and post-test randomized clinical trial.the data were collected using the socio-demographic data form for child and parent, visual analogue scale, wong-baker faces pain scale and state-trait anxiety inventory for children. the investigators found that listening to classical music, turkish music and audiobook methods played an effective role in decreasing postoperative pain and anxiety state in children in the three groups in the study. as a result, investigators showed that different auditorial attention distraction methods had a decreasing effect on postoperative pain and anxiety in children.


Eligibility criteria:
inclusion criteria: * patients aged between 7-14 years old, * staying in a single room, * those for whom a surgical procedure for inguinal or abdominal region had been planned, * in the first hour of postoperative period, * free of any problem that prevents expression of the post-operative pain, * free of hearing problems, * having undergone same analgesia protocol; were included in the study. exclusion criteria: -
ultrasound as adjunct therapy for increasing fusion success after lumbar surgery

Conditions: Lumbar Degenerative Disc Disease

Summary: adjunct therapy for increasing posterolateral fusion success following single level posterior instrumented lumbar surgery.

the purpose of this study is to determine whether using active low intensity pulsed ultrasound as adjunct therapy following single level posterior instrumented lumbar surgery increases the posterolateral success rate when compared to inactive (placebo) therapy.

Eligibility criteria:
inclusion criteria: * the subject has a documented diagnosis of degenerative disc disease with up to grade i spondylolisthesis at the target level * requires spinal fusion of a single level disc space (l2 to s1) with the use of local bone graft. * requires a posterolateral fusion procedure with or without an interbody fusion procedure using a posterior approach * the subject has failed non-operative treatment lasting at least 6 months. exclusion criteria: * requires spinal fusion at more than one lumbar level. * is pregnant, is lactating or plans to become pregnant before discontinuation of study treatment

Keywords: lumbar fusion exospine exo-spine lipus exogen
clinical and radiographic evaluation of the effect of acetal resin versus peek on supporting structure of abutment teeth

Conditions: Periodontal Diseases

Summary: this study was conducted to evaluate and compare the effect of acetal resin versus polyether ether ketone (peek) partial dentures on abutment teeth supporting structures in kennedy class i mandibular partial denture cases. clinical assessments were conducted by assessing the pocket depth (pd), plaque index (pi), and gingival index (gi). cone beam computed tomography (cbct) was used to assess abutment alveolar bone height change.

this study was a parallel, two-group, double-blinded, randomized clinical trial. the proposal and consents were approved by the research ethics committee. (rec) approval (p-pd-14-14). the helsinki declaration's guiding principles were followed when conducting the study. the comprehensive standards of reporting trials statement (consort) checklist's structure is followed in the study's presentation. the study was carried out at the outpatient clinic of the removable prosthodontic department within the faculty of dental medicine for girls at al-azhar university. in this study, fifty patients were initially evaluated. after conducting clinical and radiographic assessments, twenty patients who satisfied the inclusion criteria were selected in accordance with the sample size calculation. each patient received an explanation of every procedure, and informed consent was obtained. these twenty individuals were subsequently divided randomly into two distinct groups (ten in each): group i: ten patients received polyoxymethylene (acetal resin) partial dentures designed and fabricated using cad/cam technology. group ii: ten patients received polyether ether ketone (peek) partial dentures designed and fabricated using cad/cam technology. all patients were evaluated clinically and radiographically. clinical assessments were conducted by assessing the pocket depth (pd), plaque index (pi), and gingival index (gi) at denture insertion, three months later and six months later. cone beam computed tomography (cbct) was used to assess abutment alveolar bone height change at the time of denture placement, after three months, and after six months.

Eligibility criteria:
inclusion criteria: * every subject should be free of any systemic diseases that might influence the results of the research. * patient's residual ridges should be covered with healthy mucosa. * their salivary flow and viscosity for all within normal limits. * the patients are cooperative and ready to be called back as necessary. * had a class i angle's ridge relation exclusion criteria: * alcoholic or smokers' patients. * patients with xerostomia or excessive salivation. * patients with parafunctional habits. * patients with ulcerated or inflamed mucosa.
challenges in achieving adequate vitamin d status in the adult population/ part 2

Conditions: Vitamin D Deficiency

Summary: the efficiency of different vitamin d formulations in treating suboptimal vitamin d status in adult population will be determined. it will provide insights into the influence of formulation on vitamin d absorption. a randomised controlled intervention trial will be conducted on at least 72 subjects (18-65 years) with suboptimal vitamin d status. subjects will be selected from a pool of subjects in part 1 of the study, after completion of winter sampling. study subjects will be randomised into four study groups (at least 18 subjects per study group). three different treatments will be compared with a control group, which will not receive any supplemental vitamin d. the three tested vitamin d preparations in the treatment groups will be (a) oil-based valens vitamin d; (b) water-based valens vitamin d; and (c) vitamin d capsules with starch-adsorbed vitamin d (powder). all these products are commercially available. prior to study, actual level of vitamin d will be determined using appropriate analytical method. the treatment will be with 1000 iu vitamin d per day, for two months, in all three groups. second serum vitamin d level will be determined on last day of the treatment, and compared with pre-treatment vitamin d level.


Eligibility criteria:
inclusion criteria: * vitamin d suboptimal status * signed informed consent form (icf), * caucasian race * age between 18 and 65 years at the time of the signature of informed consent form (icf), * willingness to avoid a consumption of any food supplements containing vitamin d during the study, except the ones prescribed by the study researchers, and to avoid use of solarium or other artificial uvb sources * willingness to follow all study procedures exclusion criteria: * pregnancy or breastfeeding, * known or suspected allergy to any ingredient of the tested products in part 2, * pronounced avoidance of sunshine (eg reporting of allergy to the sun) * use of food supplements containing vitamin d or fish oil or omega 3 fatty acids in last three months prior to inclusion, * special dietary habits used by a small part of the population (veganism, low-carb high-fat (lchf) diet, caloric restriction diet, note: vegetarians are not excluded) * diets prescribed by the medical profession * disorders of the kidneys, thyroid, digestive tract, osteoporosis and other bone diseases, skin diseases * other diseases and conditions that affect the absorption and synthesis of vitamin d * exposure to stronger sunlight in the last three months prior to engaging in a survey (travel to countries with stronger sunshine, use of solarium), * the consumption of margarine or plant substitutes for milk / milk products several times a day, as these foods are most often enriched with vitamin d, * visiting the solarium in the last three months before joining the survey, * mental incapacity that precludes adequate understanding or cooperation.