Kornimate/medical-research-clean huggingface dataset:
effects of myofascial trigger point dry cupping on plantar heel pain

Conditions: Plantar Fasciitis; Heel Spur Syndrome; Chronic Plantar Fasciitis

Summary: the main aim of this study is to investigate the effects of dry cupping on calf muscle trigger points in patients with plantar heel pain. a secondary aim is to examine the correlation between several outcome measures in those patients.

plantar heel pain is a condition often seen by healthcare providers. it is presented as pain and tenderness under the heel with weight bearing activities. approximately 15% of athletic and non-athletic adults who have foot complaints seek professional care for plantar heel pain. there are different names and definitions for this condition in the literature such as plantar heel pain, plantar fasciitis, plantar fasciosis, plantar fasciopathy, heel spur syndrome, and jogger's heel. the reason for inconsistency in defining the condition is due to disagreement on the underlying pathology. a number of conditions may result in plantar heel pain, namely plantar fasciitis (most common), calcaneus fracture, heel fat pad atrophy, and peripheral nerve dysfunction. recently, several studies have shown that myofascial trigger points (mtrps) or tender points in the calf muscles may be associated with plantar heel pain. many studies have determined risk factors in the development of plantar heel pain, classifying them as either intrinsic or extrinsic. intrinsic risk factors comprise the anatomical (rom of the ankle and subtalar joints position) or demographic characteristics of the individual (age, gender, weight and height). extrinsic risk factors are related mainly to the subject's activity environment, such as running on a hard surface, time spent weight bearing, and previous injury. all these factors lead to an increase in the mechanical load on the foot, specifically the plantar fascia. treatment of plantar heel pain usually targets the plantar fascia or other structures in the plantar heel area using several interventions such as cortisone injection, therapeutic ultrasound, laser, ice, heel pads, and night splints. evidence varies regarding the effectiveness of these interventions. the main aim of this study is to investigate the immediate and carry-over effects of dry cupping on calf muscle trigger points on pain and function in patients with plantar heel pain.

Eligibility criteria:
inclusion criteria: * unilateral plantar heel pain. * trigger point(s) in the gastrocnemius/soleus muscle(s). * central or centro-medial tenderness in the plantar aspect of the heel. exclusion criteria: * red flags: tumor, fracture, rheumatoid arthritis, osteoporosis, or any severe vascular condition in the lower limbs. * neurological symptoms: sciatica, tarsal tunnel syndrome. * previous surgery in the affected leg below the hip. * fibromyalgia. * previous manual therapy treatment for the same condition within the past 6 months. * history of more than three corticosteroid injections within the past year.

Keywords: cupping dry cupping myofascial trigger points
directional versus nondirectional dbs for et

Conditions: Essential Tremor

Summary: this will be a single center (ohsu) proof of concept trial to demonstrate that directional deep brain stimulation (dbs) creates a larger therapeutic window for the treatment of essential tremor (et), effectively treats et, and minimizes effects on speech, gait and balance compared to nondirectional dbs.

specific aims: 1. to compare the therapeutic window (tw) of directional versus nondirectional deep brain stimulation for treatment of tremor. hypothesis: directional dbs will result in a wider tw than nondirectional dbs. 2. to compare the effects of directional versus nondirectional dbs on speech hypothesis: objective and subjective speech impairment will occur to a greater extent in nondirectional dbs versus directional dbs optimized for tremor control. 3. to compare the effects of directional versus nondirectional dbs on balance and gait hypothesis: objective and subjective balance and gait impairment will occur to a greater extent in nondirectional dbs versus directional dbs optimized for tremor control. 4. to assess efficacy for tremor of nondirectional and directional dbs in an optimized programming configuration hypothesis: both directional and nondirectional dbs will significantly improve tremor compared to baseline.

Eligibility criteria:
inclusion criteria: * a tremor syndrome of bilateral upper limb action tremor with at least 3 years' duration exclusion criteria: * patients who have decided not to receive dbs for control of their medication-refractory essential tremor. * patients with secondary tremor (ie not essential tremor), such as side effects from medications, secondary to another identified neurologic disease (eg multiple sclerosis, -----parkinson's disease, dystonia). * prior history of deep brain stimulation. * prior history of thalamotomy. * a history or signs of dystonia, ataxia or parkinsonism. * task specific tremor. * orthostatic tremor. * patients with cardiac pacemakers, defibrillators, or neurostimulators. * patients who require mri, ect, rtms, or diathermy. * subjects with other type of neurological disease or injury.
evaluation of the metrological reliability of connected objects in the measurement of medical physiological parameters

Conditions: Respiratory; Disorder, Functional, Impaired

Summary: many connected objects available over-the-counter to the general public claim to measure physical quantities that may have a medical application. examples include heart rate, oxygen saturation, respiratory rate, blood pressure, body composition between body fat, lean mass and bone mass, and motion analysis. . the continuous collection of these quantities by a cheap and easily accessible device opens important medical perspectives in the areas of home monitoring of chronic diseases or preventive medicine in general. nevertheless, the medical decisions that could be made on the basis of the information provided by these objects require that the measurement be reliable, which is not always the case. the evaluation of the accuracy of measurements made by these objects therefore seems to be a prerequisite for future use in a medical context. this study therefore proposes to test the adequacy between "gold-standard" measurements carried out in consultation in the department of functional explorations of the bichat claude-bernard hospital and the measurements of the same parameters by connected objects, under the conditions of intended uses by their manufacturer.

primary objective : evaluate, in patients consulting for polysomnography, respiratory functional explorations or osteodensitometry, or as part of a day hospital cardiology. the accuracy of the measurement provided by a connected object in relation to the "gold standard" measurement made during the visit. the parameters studied will be: * for polysomnography, pulse oxygen saturation (spo2), heart rate (hr) and respiratory rate (rf), sleep quality (efficacy, duration of mild slow sleep, deep slow sleep and rem sleep) * for bone densitometry, body composition in lean mass, fat mass and bone mass, weight • for respiratory function tests, pulse oxygen saturation (spo2) and heart rate (hr) * for day hospitalization in cardiology, blood pressure (bp), heart rate (hr) and heart rate, existence of rhythm disorders or conduction secondary objectives: * evaluate the ease of use of the device (evaluated by an ad-hoc questionnaire completed by the nursing staff) * describe the temporal evolution of the recorded parameters (excluding osteodensitometry for which the measurement is unique) * for day hospitalization in cardiology, evaluate the diagnostic performance of objects tested on the existence of cardiac rhythm disorders (sinus bradycardia, sinus tachycardia, atrial fibrillation, presence of extrasystoles) or conduction disorders (atrioventricular block). -ventricular, branch block)

Eligibility criteria:
inclusion criteria : * patient over 18 years old * patient sent to the functional exploration department of bichat hospital to perform one of the following exams: polysomnography, bone densitometry, respiratory function tests, cardiology day hospital assessment * patient agreement to participate in the study, * affiliated to a social security scheme (benefiting or entitled) exclusion criteria : no defined
laryngoscope force during suspension for adenotonsillectomy

Conditions: Postoperative Pain

Summary: suspension laryngoscopy is a common procedure during adenoteonsillectomy (removal of adenoids and tonsils), that consists of extending the patient's neck to allow better visualization of the tonsils. previous studies on suspension larygnoscopy have shown that the time to maximum force during this procedure predicts complications such as pain, tounge swelling and opioid requirements. moreover, monitoring these force during laparoscopy can reduce postoperative complications. however, no study to date has investigated the force metrics during suspension laryngoscopy in the pediatric population. therefore, in this study, the investigators aim to evaluate the relationship of force metrics during adenotonsillectomy, adenoidectomy or tonsillectomy and postoperative pain.

adenotonsillectomy is the most common surgery performed in north america (annual caseload in the united states 500,000). this procedure is performed with suspension laryngoscopy (sl), which consists in the extension of the patient's neck and concomitant lifting of the anterior oropharynx structures to allow direct visualization of the tonsils. in adults undergoing microlaryngoscopy, the time maximum force recorded during suspension was a significant predictive variable for the development of postoperative complications such as tongue edema, pain and narcotic requirements. force metrics during laryngoscopy vary significantly among different surgical procedures. active intraoperative monitoring of force metrics has been shown to reduce postoperative complications in adults. moreover, in adult cadaveric models, spinal cord compression associated with cord injury may be directly correlated with the force applied during laryngoscopy5,6. in patients with cervical instability, such as patients with trisomy, adenotonsillectomy carries a significant risk of spinal injury, as laryngoscopy may result in c1-c2 subluxation. to date, no data exist on force metric during suspension laryngoscopy children. the primary aim of this study is to investigate the relationship of force metrics during adenotonsillectomy, adenoidectomy or tonsillectomy and postoperative pain. the secondary aim is to describe the force metrics in the pediatric population.

Eligibility criteria:
inclusion criteria: * children ≤ 18 years old undergoing adenotonsillectomy, adenoidectomy or tonsillectomy * only patients whose parents are fluent in french or english will be enrolled exclusion criteria: * any contraindication to suspension laryngoscopy * patient/legal guardian refusal.
diet and exercise for elevated risk (deer)

Conditions: Cardiovascular Diseases; Heart Diseases; Hypercholesterolemia; Postmenopause

Summary: to determine the effect in men and postmenopausal women with elevated ldl-cholesterol and low hdl-cholesterol of an exercise regimen with or without the national cholesterol education program (ncep) step two diet compared to usual care control group on hdl- and ldl-cholesterol.

background: the ncep is a major public education program providing advice to physicians and the public on management and prevention of coronary heart disease. however, data supporting the advice are derived primarily from middle-aged men, with less data available for women and older individuals. furthermore, there have been recent reports that when low saturated fat diets such as the ncep step one and ncep step two diets, are followed, hdl-cholesterol is lowered as well as ldl-cholesterol. design narrative: randomized, controlled, factorial design powered for men and women separately. one hundred eighty postmenopausal women, 45 through 64 years of age, and 197 men, 30 through 64 years of age, who had low high-density lipoprotein (hdl) cholesterol levels (\ 125 mg per deciliter but \ 125 mg per deciliter but \<190 mg per deciliter in men) were enrolled. the subjects were randomly assigned to aerobic exercise, the ncep step 2 diet, or diet plus exercise, or to a control group, which received no intervention. the four interventions were delivered for one year: usual care (written dietary materials only with delayed intervention optional), exercise only (supervised, progressive aerobic exercise program at least three times per week), diet only (group and individual dietary instruction on the ncep step one/step two diet delivered by registered dietitians), and diet plus exercise. at baseline and at the end of one year, measurements were made of blood lipids and lipoproteins, plasma glucose and insulin, glucose tolerance, blood pressure, body composition through hydrostatic weighing and waist and hip circumterences, aerobic fitness (vo2 max), and five unannounced 24-hr. recalls. the primary outcomes measured was hdl-cholesterol, major secondary endpoints included ldl-c, ldl-c/hdl-c ratio, and triglycerides.

Eligibility criteria:
men with with ldl-cholesterol of 125-189 mg/dl and hdl-cholesterol below or equal to 44 mg/dl, and postmenopausal women, age 45 to 64, with ldl-cholesterol of 125 to 209 mg/dl and hdl-cholesterol below or equal to 59 mg/dl.
a study of linperlisib combination with camrelizumab in patients with solid tumor

Conditions: Advanced Solid Tumor

Summary: it is a single-arm, open-label, multicenter, phase i trial,aiming at exploring the mtd and rp2d of linperlisib combination with camrelizumab in treating patients with advanced solid tumor,observing the preliminary efficacy.

the trial can be divided into two parts: dose escalation part and dose expansion part. camrelizumab will be administrated intravenously in a predetermined fixed dose(200mgq3w）in both parts. in dose escalation part,linperlisib will be administrated from 40mgqd,60mgqd to 80 mgqd in sequence with the classic "3+3" design.the purposes of this part are figuring out the mtd and rp2d of linperlisib combination with camrelizumab in treating patients with advanced solid tumor,and observing the pk characteristics of linperlisib when using combination with camrelizumab. when finishing the dose escalation part,one combination dose of linperlisib with carelizumab will be selected to be studied on a wider scale of patients with advantage solid tumor in dose expansion part.purposes of this part are further observing the pk characteristics of linperlisib when using combination with camrelizumab,while observing the preliminary efficacy of linperlisib when using combination with camrelizumab.

Eligibility criteria:
inclusion criteria: * 18 years old≦age≦75 years old; * histologically or cytologically confirmed locally advanced or metastatic malignant solid tumors； * failure of previous standard treatment (sufficient prior treatment and no better treatment than participating in clinical research); * qualified basic organ function and body condition; * the expected survival is greater than 3 months; * adequate washout period. exclusion criteria: * prior allergy to study drug components; * chronic metabolic diseases that are poorly controlled by medication; * brain metastases, infection, hemorrhage, autoimmune disease or cardiovascular disease, whichever is in active state; * digestive tract diseases that affect absorption of studied drugs.

Keywords: pi3k inhibitor pd-1 inhibitor advanced solid tumor
pectoralis (ii) block with liposomal bupivacaine vs bupivacaine for breast surgery

Conditions: Pain, Postoperative

Summary: this is a randomized controlled pilot study evaluating length of pain control with either liposomal bupivacaine or with bupivacaine plus decadron after pec ii injection in patients having bilateral mastectomies with immediate reconstruction.

this research hopes to determine the duration of patient-reported analgesia provided by ultrasound guided pec ii field block injections. the design of the study randomly assigns the side of injection of the study drugs into each patient. all patients are having bilateral mastectomy with immediate reconstruction. visual analog pain scores (vas) will be recorded serially for both sides of the patient's chest in hopes of determining a difference in duration and efficacy of the two drugs. in addition to vas scores, a subjective, binary question will be our primary outcome: does one side of your chest have more surgical pain than the other? we hope that his question, despite being entirely subjective, overcomes interpatient variability of numerical pain score reporting.

Eligibility criteria:
inclusion criteria: * scheduled for bilateral mastectomy exclusion criteria: * allergy to local anesthetics, prior breast surgery, asymmetric surgical plan
blitz atrial fibrillation

Conditions: Atrial Fibrillation

Summary: management strategies for af have made many advances over the last decade but there is still a great heterogeneity in the management of af and it remains unclear how often clinicians adhere to current guidelines. a survey of an updated af management would enable a timely assessment of implementation of current international guidelines, allow monitoring of early management of af when a patients is admitted in a emergency room (er) and cardiology unit.

multicentre, observational study. 200 italian hospitals fully representing the italian cardiology reality in terms of geographical distribution and level of hospital technology. data collection in er: data on af and atrial flutter episodes in er will be collected retrospectively by checking the records of er without collection of any data that can allow to identify the patients. these data will be collected under the responsibility of the cardiology departments consecutively for 4 weeks. data collected in cardiology: these data will be collected under the responsibility of the cardiology departments for 12 weeks consecutively.

Eligibility criteria:
inclusion criteria: * all patients with af, admitted to cardiology wards for an urgent or planned hospitalization. * all patients admitted in a day hospital regimen for treatment of af the diagnosis of af must be confirmed by ecg. * signed patient inform consent. exclusion criteria: * the qualifying episode of af was not documented with an ecg. * age \<18 years. * patients with af as a complication of an acute coronary syndrome (within 1 week from symptoms onset). * patients with af associated with cardiothoracic surgery (within 1 week from surgery). * concomitant participation in other studies that can modify the diagnostic and/or therapeutic treatments. * patients already enrolled in blitz-af

Keywords: atrial fibrillation
understanding gwi: integrative modeling

Conditions: Gulf War Illness; Persian Gulf Syndrome; Occupational Diseases

Summary: the investigator proposes to perform a phase i study assessing safety, efficacy, and biomarker response to the therapeutic interventions of etanercept followed by mifepristone for veterans with gulf war illness. the investigator will conduct and repeat the exercise challenge before treatment and on therapy to assess the impact of the interventions on homeostatic regulation and the dynamic model identified in prior studies.

in the investigator's prior work, the investigator used an exercise stress model (rest, peak oxygen consumption oxygen uptake, and 7 follow-up sampling points) to measure the mediators of relapse in the context of their interactive homeostatic networks. the investigator surveyed the response of genes and blood-borne biomarkers in order to interrogate and map the regulation of neuro-endocrine-autonomic-immune function in these subjects as compared to gw era sedentary healthy controls. this study is the first to test in the gwi human system of the impact of interventions that hope to permanently re-set the key pathway(s) involved in maintaining a "sick" homeostatic network in gulf war illness, discovered in our prior cdmrp and va funded projects. an open-label phase i study will be performed with etanercept (once a week for 4 weeks) followed by mifepristone (once a day for 7 days), followed by a 10-week observation to assess safety, efficacy and biomarker response to maximal exercise. the impact of the interventions will be measured on current computational modeling of dynamic response gwi illness mediators at onset, at 6 weeks (on completion of the medication regimen) and 4 months after baseline; using 20 gwi patients. the response during and after an exercise challenge will be assessed followed by map the homeostatic networks in play over the 24 hours post-exercise in subjects before treatment, after completing the second treatment (week 6) and 4 months after initiating treatment (week 16).

Eligibility criteria:
inclusion criteria: * male veterans who were deployed in 1990 -1991 gulf war. * veterans who currently meet the kansas gulf war study case definition for gulf war illness. * veterans who were in good health based on medical history prior to 1990. * veterans who are between 40 to 70 years old * veterans who currently do not have exclusionary diagnoses that could reasonably explain the symptoms of their fatiguing illness and their severity. exclusion criteria: * major depression with psychotic or melancholic features * schizophrenia * bipolar disorder * delusional disorders * dementias of any type * history or current alcohol abuse * history or current drug abuse * organ failure * transplant * defined rheumatologic * inflammatory disorders * hiv * hepatitis b and c * primary sleep disorders * steroids * immunosuppressives * medications that impact immune function such as enbrel or methotrexate * tuberculosis or past history of tuberculosis exposure, as documented by ppd positivity

Keywords: anti-neuroinflammatory homeostatic regulation hpa axis regulator