Kornimate/medical-research-clean huggingface dataset:
flurbiprofen tablet vs spray in oral soft tissue wounds

Conditions: Oral Soft Tissue Conditions; Drug Effect; Drug Use

Summary: the amount of active ingredient in tablet form of flurbiprofen is higher than that in the oral spray form. therefore, based on the hypothesis that the side effects that may occur depending on the dose can be reduced, this clinical study investigated whether tablet and spray form flurbiprofen would have similar effects on postoperative pain in primarily closed soft tissue wounds in the oral region.

in line with the number of patients obtained after sample size calculation, the study was completed on 40 patients who met the inclusion criteria. patients were healthy, volunteer individuals who required excision of the epulis fissuratum or frenulum with the indication of preprosthetic surgery. 2 groups were formed by simple randomization with 20 patients in the tablet group and 20 patients in the spray group. after the surgical procedure, tablet and spray flurbiprofen were prescribed according to the groups. apart from these, paracetamol, chlorhexidine gluconate + benzidamine hydrochloride mouthwash were prescribed to all patients as rescue analgesics. the tissue fragments removed from the patients who underwent epulis excision were sent for histopathologic evaluation and confirmed.

Eligibility criteria:
inclusion criteria: * provided that those using removable prosthesis had discontinued using the prosthesis 1 month ago (in order to minimize the lesion to be excised), healthy or asa class i patients between 40 and 65 years of age, who had the indication of pre-prosthetic surgery due to excision of epulis fissuratum and frenulum exclusion criteria: * pregnancy, lactation, and taking contraceptive pills; being allergic to the drug or other nsaids to be used in the study; had used steroids or analgesic drugs for any reason for the last 1 month; using psychiatric drugs; those with incomplete data and refused to sign the consent form; those who were extremely afraid and had a gag reflex; those with any gastrointesinal problems; smoking, asa-2 and asa-3 patients and those who smoked.

Keywords: flurpibrofen oral soft tissue
the precision of pulmonary artery cardiac output-measurements in spontaneously breathing patients

Conditions: Heart Diseases

Summary: the intention of this study is to determine whether the precision of the measure of cardiac output can be optimized by conducting the measurement while the participant is instructed to exhale slowly. this will be compared to measurements done at random to respiration and timed with the participant's spontaneous expiration.


Eligibility criteria:
inclusion criteria: * every patient that receives a pulmonary artery catheter (pac) related to elective cardiac surgeries, * informed and written consent to participation in the study in accordance with the helsinki declaration * hemodynamic stability exclusion criteria: * hemodynamical instability * atrial fibrillation * tricuspid insufficiency ≥ grade 2 * hemodialysis or other conditions where extra volume load can be negative, * lack of ability to give a written consent to participate in the study

Keywords: cardiac surgical procedures pulmonary artery catheterizations cardiac output swan ganz catheterization
rct of home-based vs formal physical therapy for treatment of new onset non-insertional achilles tendinopathy

Conditions: Achilles Tendinopathy

Summary: the goal of this prospective randomized controlled trial is to compare the effectiveness of a home-based exercise protocol to formal physical therapy in patients who have been diagnosed with achilles tendinopathy. the null hypothesis is that there will be no difference in the treatment outcomes between patients with achilles tendinopathy who participate in a home-based program versus patients with achilles tendinopathy who undergo formal physical therapy. participants will be randomized to a 12-week home-based or formal physical therapy protocol and asked to complete brief outcomes surveys at their initial visit, and at 6 weeks, 12 weeks, 6 months, and 1 year after their initial visit.


Eligibility criteria:
inclusion criteria: * must be 18 years of age * must have a new diagnosis of achilles tendinopathy that has presented with pain, thickening and tenderness at the mid substance of the achilles tendon * symptoms present for at least 6 weeks exclusion criteria: * patients with insertional achilles pain or tenderness or concomitant plantar foot pain * patients who have had prior treatment with home eccentric stretching or physical therapy * patients who have prior diagnosis and treatment for achilles tendinopathy * patients with history of injection (corticosteroid or sclerosing agents) to the achilles tendon * patients with inflammatory arthritis * recent fluoroquinolone antibiotics (these agents are known to alter achilles tendon physiology) * patients who have had prior foot or ankle surgery * individuals that do not speak english * bilateral disease * pregnant women
percutaneous nephrolithotomy versus extracorporeal shock wave lithotripsy

Conditions: Kidney Stones

Summary: the investigators main hypothesis is that the stone free rate will be much higher (95%) in patients treated with pcnl than patients treated with eswl where stone free rate is (60%) to determine which treatment is safe and prevent less stone recurrence.

extracorporeal shock wave lithotripsy is preferred for small stones less than 10 mm in size. percutaneous nephrolithotomy is the standard therapy used for large kidney stones greater than 20 millimeters or stones in the lower kidney. for moderate sized kidney stone (10-20 mm),currently the options for treatment include both methods. however, no studies have proven that one procedure is better than the other. so, we will compare both the procedures for breaking the kidney stone. our main outcome measures will be the stone-free status after the procedure. other outcome measures are assessment of morbidity associated with use of the procedures i.e. any minor or major complications within 3 months of initial treatment. patient will be assessed for infection at post-operative office visits to include a basic urinalysis only if they have systemic indicators of infection (fever, dysuria, frequency, etc.). pain will be monitored with the scale of 0-10 points. also we will review of stone density on computerized tomography (ct) scans and the effect this has on success of both procedures. we hope with pcnl stone-free rates will be minimum with minimal morbidity and ultimately improve patient care.

Eligibility criteria:
inclusion criteria: * patients of both sex with age greater than 18 years to 90 years * stone burden between 10 and 20 mm diagnosed by ct scan * patient must be agreeable to randomization between shock wave lithotripsy and percutaneous stone removal exclusion criteria: * patients with bleeding diathesis or taking anti-platelet or anti-coagulant medication * patients who are pregnant based on routine pre-operative pregnancy testing * patients with skin to stone size greater than 12 cm (measured routinely on ct scan) * patients with either horseshoe kidney, transplant kidney or a solitary kidney * patients with ureteral calculi * patients with stone size of \ 20 mm * ureteropelvic junction obstruction
estimation of pain during epidural analgesia during labor

Conditions: Labor, Obstetric; Pain

Summary: epidural regional anesthesia is a technique to eliminate or lessen pain during obstetric labor and childbirth. it consists in establishing a catheter into the epidural space and to block the transmission of pain sensations by injecting a local anesthetic and an opioid. in 10-25% of cases the epidural does not give perfect results, causing it to test its effectiveness, which is mainly done by questioning the patient on mitigation or disappearance of pain. this collaboration of patients is sometimes limited in our care structure by the inability to assess or express the pain, mainly due to cultural differences or language barriers, which can represent up to 15% of women in our institution. this led to develop objective measures of pain techniques used at the bedside. pupil diameter (pd) varies under the double influence of sympathetic system (σ), dilator of the pupil, and parasympathetic system (pς). the pd increases in response to painful stimulation, in proportion to the intensity of the nociceptive stimulus. this variation of pd has been proposed as a means of evaluation of pain in patients under general anesthesia, but has been little studied in conscious subjects. there are other permanent changes in the pd, due to constant interaction between σ and pς systems. few data have been published to date on this pd variability (pdv).


Eligibility criteria:
inclusion criteria: * obstetrical labor * able to rate their pain using vas * dilatation of the cervix under 6 centimeters * written consent exclusion criteria: * - not having a anesthesia consultation during the 48 hours before delivery * with a contra-indication for an epidural * to which an incident occurred during a previous epidural using a medication used in the study * operated a unilateral or bilateral ocular surgery modifying the possibilities of variation of pupil diameter * general anesthesia in the seven days preceding delivery * carry a pacemaker or heart grafted * having parkinson's disease history, insulin or non-insulin diabetes or chronic alcoholism * having cardiac arrhythmia (atrial fibrillation or frequent extrasystoles) * treated for hypertension by receptor antagonists of angiotensin type 2 * anti-arrhythmic treatment or blocker, * refusing to participate in the study * with a contra-indication for the use of ropivacaine and sufentanil.

Keywords: labor, obstetric pain pupil diameter visual analogic scale (vas)
the efficacy of a telerehabilitation pilates program in fibromyalgia syndrome patients

Conditions: Fibromyalgia Syndrome

Summary: the study aims to evaluate the effects of a telerehabilitation-based clinical pilates program in patients with fibromyalgia syndrome. a randomized controlled trial was designed. an online clinical pilates-based exercise program targeting stability and strength that was conducted for 8 weeks with 2 sessions per week was developed for the telerehabilitation group. the same exercise programs for the control group were provided in brochures.


Eligibility criteria:
inclusion criteria: * diagnosis of fms at least one year before the study * stable general health condition for the past 6 months exclusion criteria: * inability to cooperate with measurements * regular engagement in exercise

Keywords: fibromyalgia pain telehealth telemedicine
oral contraceptive pill and gnrh antagonist versus long protocol in ivf patients

Conditions: Infertility

Summary: recent controversy has arisen regarding the use of the pill for cycle planning in gnrh antagonist ivf cycles. the investigators performed this study to compare such a protocol with the gold-standard still today, which is the long-agonist protocol with no previous use of the pill.


Eligibility criteria:
inclusion criteria: * 1st or 2nd ivf cycle * bmi \<30 kg/m2 * regular menstrual cycles * basal fsh \<10 iu and e2 \<60 pg/ml exclusion criteria: * polycystic ovaries * endometriosis * previous ovarian surgery * previous low ovarian response

Keywords: infertility patients requiring ivf good prognosis
titanium mesh versus collagen membrane for closure of window in maxillary sinus elevation with implant placement

Conditions: Edentulous; Alveolar Process, Atrophy

Summary: evaluation the amount of bone height gained when using titanium mesh in closing the lateral window of the sinus compared to collagen membrane.evaluation the quality of new bone gained when using of the titanium mesh to close the lateral window of the maxillary sinus as a new option for tenting compared to collagen membrane.

this study is aimed to review the bone height, quality and closure of lateral osteotomy used for maxillary sinus floor lifting comparing titanium mesh to collagen membrane.

Eligibility criteria:
inclusion criteria: * no signs of sinus pathology non or light smokers less than 20 cigarettes per day no systemic disease that may affect normal healing no pscychiatric problems no history of neoplasms or radiation therapy to the head and neck no previous bone augmentation to implant site exclusion criteria: * sinus pathology. heavy smokers more than 20 cigarettes per day patients with systemic disease that may affect normal healing. psychiatric problems disorders to implant are related to history of radiation therapy to the head and neck neoplasia, or bone augmentation to implant site.
a single dose, 4-period, 2-treatment replicate design bioequivalency study of granisetron hydrochloride 1 mg tablets under fasting conditions

Conditions: Nausea; Vomiting

Summary: the objective of this study was to assess bioequivalence of a potential generic 1 mg granisetron tablet formulation compared with roche laboratories' 1 mg granisetron tablet, kytril, following a single 1 mg dose, under fasting conditions.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal finding on the physical examination, medical history, or clinical laboratory results during screening. exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enzyme altering drugs. * history of allergic or adverse response to granisetron or any other comparable or similar drug.

Keywords: prevention of nausea and vomiting associated with radiation or chemotherapy
prevalence of atelectasis in critical trauma patients

Conditions: Pulmonary Atelectasis

Summary: the purpose of this study is to identify the prevalence rate and risk factors for pulmonary complications in patients with critical trauma who intubated and mechanical ventilation.


Eligibility criteria:
inclusion criteria: * an inclusion criterion is the traumatic patients (e.g. head injury, blunt chest, blunt abdomen, and fracture of spine; with or without operative, pure or multitrauma) with intubation and mechanical ventilation who admit at this time period will recruit to the study. exclusion criteria: * a patients who admit less than 1 day will be excluded such as sudden death or moving to other ward because of improving conditions, etc.

Keywords: trauma atelectasis
vaccination with autologous dendritic cells pulsed with hiv-antigens for treatment of patients with chronic hiv-infection

Conditions: HIV Infections

Summary: phase i test of concept study: in an attempt to induce new immunity to hiv-1 during untreated hiv-1 infection the investigators have identified relatively immune silent immune subdominant hla-a2-restricted hiv-1 ctl epitopes that fit individuals with the hla-a2 tissue type (about 50% of peoples in denmark). immunising with these conserved epitopes could induce new immunity and lower viral load so the patient will live longer before aids or antiviral medicine and a lower viral load will limit spread in the population. as adjuvants the investigators used patients' own autologous dendritic cells generated from blood cells in vitro. 12 healthy male hiv-1 infected not in therapy individuals were used for this therapeutic vaccination and tested for safety and induction of new cellular cd8 and cd4 t-cell immunity.


Eligibility criteria:
inclusion criteria: * hiv positive male * viral load \>1000/ml * cd4 count \>300 * hla-a2 tissue type * 18-50 years of age * able to follow the instructions * informed consent exclusion criteria: * treated with other experimental vaccines or immune modulatig medicine * other chronic infectious diseases * allergy or autoimmune disease

Keywords: hiv-1 hla-a2 therapeutic vaccine treatment vaccine treatment naive
probiotics pilot project

Conditions: Staphylococcus Aureus

Summary: this pilot study is designed to determine if ingestion of bacillus probiotics can cause alteration in levels of s. aureus colonization in the nose and intestine in preoperative orthopedic patients undergoing elective primary tja.


Eligibility criteria:
inclusion criteria: 1. adults (age \>18 years) 2. undergoing elective primary knee or hip arthroplasty 3. confirmed colonization of nares and/or rectum with s. aureus or mrsa on routine standard-of-care preadmission testing 4. written informed consent exclusion criteria: 1. regular use of a probiotic or prebiotic supplement within 3 months prior to enrollment 2. antibiotic use within 3 months prior to enrollment 3. active clinical infection 4. participation in other clinical trials 5. presence of pregnancy or lactation
online intervention based on pain neuroscience education for women with pregnancy-related lumbopelvic pain

Conditions: Low Back Pain

Summary: 60-70% of pregnant women suffer from pregnancy-related lumbopelvic pain. in the general population, patient education is the first line of treatment. for pregnant women with lbp, the guidelines are the same as for the general population. in fact, prenatal education programs specifically collect recommendations and educational strategies for managing this pain. within educational strategies, education in the neuroscience of pain has gained special relevance in recent years due to its positive results in reducing pain in patients with low back pain. despite the beneficial effects shown in patients with low back pain, its use has not yet been explored, to our knowledge, in women with pregnancy-related lumbopelvic pain.

60-70% of pregnant women suffer from pregnancy-related lumbopelvic pain. its multifactorial origin makes it difficult to establish an appropriate treatment for pain control. in the general population, patient education is the first line of treatment. for pregnant women with lbp, the guidelines are the same as for the general population. in fact, prenatal education programs specifically collect recommendations and educational strategies for managing this pain. within educational strategies, education in the neuroscience of pain has gained special relevance in recent years due to its positive results in reducing pain in patients with low back pain. this type of education is based on reconceptualizing pain through teaching the neurobiological mechanisms that underlie the pain experience. despite the beneficial effects shown in patients with low back pain, its use has not yet been explored, to our knowledge, in pregnant women with pregnancy-related low back and pelvic pain.

Eligibility criteria:
inclusion criteria: * pregnant women older than 18 years, who are in the early third trimester of pregnancy; * minimum score of 3/10 on the numerical pain scale over the past week. exclusion criteria: * multiple pregnancy; * previous spinal surgery; * presence of psychiatric disorders; * women who have participated in similar programs or interventions before enrollment.
study of the cutaneous reinnervation after burn

Conditions: Post-burn Innervation

Summary: the aim of this study is to understand why the regeneration of the cutaneous sensory nerve fibers is poor in post-burn scar. the presence or the lack of several molecular factors known to regulate neuronal cell development will be evaluate and compared within biopsies from healthy skin and post-burn scar.


Eligibility criteria:
inclusion criteria: * major patients * at least one year back deep burn (2nd and 3rd degrees), and allowing the comparison between the post-burn scar dermatome and the healthy opposite dermatome * patients always followed in the service of plastic surgery of the hospital of brest * informed consent and paper of the patient after information of the objective of the study and the protocol * analog visual scales for pain and/or pruritus (eva): greater than or equal to 3 * simple verbal scales for the pain and/or the pruritus ( evs): pain / pruritus moderated to intense * membership to the social security exclusion criteria: * allergy to xylocaine * non-caucasian patients * treatments having an effect on the pain and/or the pruritus * sun or uv exposure several days preceding or following the biopsies

Keywords: molecular factors cutaneous innervation skin biopsy post-burn scar
medication management and culture of safety

Conditions: Cardiovascular Disease

Summary: there will be no significant decrease in the use of low dose acetylsalicylic acid (asa) therapy for primary prevention across the three intervention arms from baseline to completion of the project. there will be no significant differences in the percentage of patients with diabetes mellitus greater than 44 years of age on low dose asa therapy for primary prevention across the three arms of the study using repeated measures from baseline to completion of the project.

we will assess the current use of aspirin therapy for primary and secondary cardiovascular disease prevention in six general internal medicine and family medicine clinics within the university of colorado hospital system using electronic health record data. we will develop messages concerning the appropriate use of aspirin for cardiovascular disease prevention for academic detailing to clinicians, a point of care (ehr) decision support aid for clinicians, and a short information sheet (generated by a cds) for patients. we will test the effectiveness of interventions to improve the evidence-based use of aspirin for primary and secondary prevention of cardiovascular disease using a randomized trial in the six university of colorado hospital primary care practices studied. the three intervention arms will include: 1.academic detailing and cessation of the primary prevention reminder within the point of care clinical decision support system (ehr/cds) only 2. academic detailing with an ehr/cds message asking clinicians to consider stopping aspirin therapy for primary prevention embedded in the point of care clinical decision support system 3. academic detailing with the ehr/cds point of care message for clinicians in the second paragraph above, and a short information sheet to be given to patients prior to a visit to ask them to check with their provider concerning their use of aspirin for primary prevention -

Eligibility criteria:
inclusion criteria: * all patient on low-dose aspirin without an appropriate diagnosis of coronary artery disease or thrombotic stroke/transient ischemic attack (tia) within the six practices. exclusion criteria: * persons not on aspirin therapy or persons on aspirin therapy for reasons other than prevention of cardiovascular disease (i.e., pain relief) will not be included in the study.

Keywords: cvd primary prevention asa physician behavioral change patient behavioral change
outcomes of critically ill patients undergoing rrt- a registry based study.

Conditions: Renal Replacement Therapies; Outcome Assessment

Summary: rationale: acute kidney injury (aki) requiring renal replacement therapy (rrt) is a frequently occurring entity among critically ill patients. this study aims to determine the outcomes of patients undergoing renal replacement therapy in the icu. study objective: to find the outcomes of patients undergoing rrt in the icu in terms of mortality and length of icu stay. design: a registry based, retrospective, descriptive study. sample size: convenience sampling of all the patients who require rrt during the icu stay. duration: retrospective data from three years january 1, 2020 to december 30, 2023. place: intensive care units (icus) of the department of critical care medicine, tribhuvan university teaching hospital (tuth). interventions: not applicable expected results: the study will help determine the outcomes of the critically ill patients undergoing rrt in a low middle income country icu.


Eligibility criteria:
inclusion criteria: * age\>18 years * admission to the icu * all patients undergoing rrt during icu stay exclusion criteria: * none

Keywords: renal replacement therapy hemodialysis intensive care unit outcomes