Kornimate/medical-research-clean huggingface dataset:
midds ankle fracture

Conditions: Ankle Fracture Requiring Internal Fixation

Summary: the geko™ device is indicated for the prevention and treatment of oedema. the aim of this study is to show that recruiting, and performing study assessments in ankle fracture patients requiring surgery to fix their ankle attending the james cook hospital is feasible, and to obtain data to support the powering of a larger study to demonstrate the effectiveness of the geko™ device at reducing length of stay for this population of patients. this study will also allow us to assess the acceptability, tolerability and compliance of treatment with the geko device.


Eligibility criteria:
inclusion criteria: 1. aged 18-60 years old 2. clinically and radiologically diagnosed acute ankle fracture that, in the opinion of the treating surgeon, requires operative fixation 3. able to understand the patient information sheet (pis) and willing to sign the written informed consent form. 4. able and willing to follow the protocol requirements. exclusion criteria: 1. has a pacemaker 2. morbid obesity (bmi index \>40kg/m2). 3. patients who on presentation to hospital are known to be pregnant. 4. clinically significant co-morbidities that need to be treated prior to surgical intervention and could therefore impact upon time to theatre 5. history or signs of previous deep or superficial vein thrombosis/pulmonary embolism. 6. varicosities, ulceration or erosion around the area of the leg where the study device would be fitted 7. diabetic 8. already taking part in a clinical study, or has so within the last 8 weeks 9. none responder to geko™ device
evaluate the efficacy of the treatment of iatrogenic subcutaneous abdominal wounds (isaw) after surgery by application of negative pressure wound therapy (npwt) in comparison to standard conventional wound therapy (scwt) of the clinical routine

Conditions: Postoperative Abdominal Wounds; Wound-healing Impairments

Summary: the purpose of this study is to determine whether negative pressure wound therapy (npwt) or standard conventional wound therapy (scwt) are effective in the treatment of iatrogenic subcutaneous abdominal wound healing-impairments (isaw).

the aim of the study is the comparison between npwt and standard conventional wound therapy (scwt) under clinical, safety and economic aspects in the treatment of postoperative iatrogenic subcutaneous abdominal wounds (isaw). the hypothesis is based on the assumption that the application of npwt for the treatment of postoperative abdominal wound healing impairments (with intact fascia) results in a decrease of time until achievement of wound closure (with confirmation after 30 consecutive days) and for this reason more wound closures can be achieved in the maximum treatment period of 42 days compared to the control therapy.

Eligibility criteria:
inclusion criteria: * acute subcutaneous abdominal wound-healing impairment after surgical intervention * sizes of wound opening (maximum diameter ≥ 3 cm) * wound surface ≥ 9 qcm exclusion criteria: lack of infrastructure for outpatient continuation of treatment and study-specific interventions * existence of an open abdominal fascia * acute serious organ failure * application of an other active vacuum device at the wound treated during the study conduct within 8 days before screening visit * ongoing / during 3 weeks after chemo therapy * ongoing / during 3 weeks after radiation therapy contraindications in accordance with the safety precautions issued by the fda or the companies

Keywords: wound healing impairments, negative pressure wound therapy, health services research, germany
the impact of shallow reading in social media

Conditions: Social Media; Mental Health Disorder; Brain Imaging

Summary: social media is pervasively used in our life. there is a research hypothesis that the information in social media is "shallow" and the long-term use of it will cause readers' addiction, insomnia, and inability to pay attention, thus reducing the efficiency of learning and working. however, there is no systematic study on the relationship between "shallow reading" in social media and attention, addiction, sleep quality, and other mental health. therefore, the investigators intend to explore the effect of "shallow reading" in social media on mental health based on about 300 healthy subjects by conducting questionnaire, cognitive scale assessment, multi-mode mri scanning and eeg monitoring. a cross-sectional study will be combined with a longitudinal study to explore the clinical characteristics its relationship to brain function.

with the development of social media such as "twitter", "facebook" and "microblog", "shallow reading" has gradually become the main way for people to obtain external information and relax. "shallow reading" is characterized by incomplete and intermittent reading patterns, and readers often "dip into it" without thinking. there is a research hypothesis that the information in social media is "shallow" and the long-term use of it will cause readers' addiction, insomnia, and inability to pay attention, thus reducing the efficiency of learning and working. some researchers even concern that "shallow reading" is destroying human beings' suspicion spirit, thinking ability and rational thinking which are based on writing and print culture. however, there is no systematic study on the relationship between "shallow reading" and attention or other mental health, not to mention its fmri and eeg characteristics. therefore, the investigators intend to explore the effect of "shallow reading" in social media on mental health based on about 300 healthy subjects by conducting questionnaire, cognitive scale assessment, multi-mode mri scanning and eeg monitoring. a cross-sectional study will be combined with a longitudinal study to better understand both the short-term and long-term effect of "shallow reading" habit to the mental health and imaging characteristics. the collected indexes will be analyzed to explore the clinical characteristics of people with the habit of "shallow reading", and its relationship to mental health, brain imaging characteristics will finally be clarified.

Eligibility criteria:
inclusion criteria: 1. health volunteers 2. capable to use smartphone exclusion criteria: 1. participants with a bmi greater than 30 or less than 18.5 2. any use of cigarettes or alcohol 3. color blindness 4. left-handedness 5. with mental or psychiatric disorders 6. with cognitive impairment 7. has a history of brain trauma 8. has a family history of psychiatric disorders

Keywords: social media shallow reading multimodal mri brain network
a real-world evidence study of bnt162b2 mrna covid-19 vaccine among children in brazil

Conditions: COVID-19

Summary: the present test-negative design study aims to estimate the real-world effectiveness of pfizer-biontech bnt162b2 mrna vaccine on symptomatic sars-cov-2 infection and its consequences among children aged 5 to 11 years in the city of toledo in southern brazil. individuals aged 5 to 11 years who seek the public healthcare system with symptoms suggestive covid-19 will be enrolled. participants with a positive reverse transcriptase polymerase chain reaction (rt-pcr) test for sars-cov-2 will be classified as cases, and those with negative rt-pcr test for sars-cov-2 will be classified as controls. cases will be followed-up for a period of 3 months by means of structured telephone interviews.


Eligibility criteria:
inclusion criteria: * age between 5 and 11 years; * resident of toledo city; * seeking care in the public healthcare system with symptoms suggestive of covid-19 defined as follows: 1) ari symptoms (nasal congestion, rhinorrhea, anosmia, sore throat, hoarseness, new or increased-from-baseline cough, sputum production, dyspnea, wheezing, myalgia) or 2) admitting diagnosis suggestive of ari (pneumonia, upper respiratory infection, bronchitis, influenza, cough, asthma, viral respiratory illness, respiratory distress, and/or respiratory failure). * nasal or nasopharyngeal sample for sars-cov-2 test obtained as standard of care. exclusion criteria: * sars-cov-2-directed antiviral treatment within the past 30 days; * covid-19 monoclonal antibody therapy within the past 90 days; * covid-19 convalescent serum therapy within the past 90 days; * failure to perform rt-pcr for diagnosis of sars-cov-2 infection.
examining the effect of occupational therapy-based parent coaching on feeding problems in children with a preterm birth

Conditions: Feeding Behavior; Mother-Child Relations; Feeding and Eating Disorders

Summary: feeding problems are common in children with a history of premature birth, and these problems continue into early childhood. feeding problems are affected by many biopsychosocial factors, and the context in which feeding takes place and the attitudes and behaviors of parents can also be effective in the emergence or continuation of these problems. the aim of our study is to evaluate the effects of occupational therapy-based parent coaching intervention on mothers and their children, who are considered to be primarily responsible for the feeding of children in our country. 46 mothers with premature children will be included in our study and participants will be randomly assigned to intervention/control groups. mothers will fill out a sociodemographic information form, behavioral pediatric feeding assessment scale, sensory profile questionnaire - oral sensory processing subtest, family feeding strategies scale and parental self-efficacy scale via google forms. mothers in the research group will be given online occupational therapy-based parent coaching training for 10 weeks. second evaluations will be carried out after the training; final evaluations will be applied after 1 month of follow-up.


Eligibility criteria:
inclusion criteria: * prematurity of the child (birth week \<37) * the child is between 3-6 years old * the mother must have the competence to use online platforms, technological tools and internet connection. * the mother must have sufficient education to read, understand and fill out the scales. * mothers reporting complaints about feeding problems in their children exclusion criteria: * it may affect the child's feeding; having a food allergy, disability, neurodevelopmental disease, chromosomal or structural anomalies * the child is fed non-orally * being receiving occupational therapy, oral motor therapy or nutritional therapy at any center * not allowing practices such as video sharing, camera/audio sharing, and recording of sessions during the intervention.

Keywords: prematurity feeding problems occupational therapy parent coaching
chemoradiotherapy following immunotherapy plus chemotherapy for locally-advanced esophageal squamous cell cancer (rice)

Conditions: Esophageal Squamous Cell Carcinomas; Concurrent Chemoradiotherapy; Immunotherapy; Chemotherapy

Summary: this is an investigator-initiated, single-arm, exploratory clinical study.the study population consisted of non-operative locally advanced esophageal cancer . the purpose of this study was to evaluate the efficacy and safety of concurrent chemoradiotherapy following immunotherapy plus chemotherapy for patients with locally-advanced esophageal squamous cell cancer.


Eligibility criteria:
inclusion criteria: 1. age:18-75 years of age; 2. histologically confirmed squamous cell carcinoma; 3. locally-advanced ,medical inoperability, technical irresectability, or patient refusal to surgery; 4. eastern cooperative oncology group (ecog) performance status:0-2; 5. able to eat a semi-liquid diet; 6. less than 20% weight loss within 6 months; 7. adequate hepatic function, renal function, hematologic function and coagulation function; 8. documented informed consent. exclusion criteria: 1. distant metastasis; 2. known malignancy diagnosed or require active treatment in the last 5 years, except for cancers that can be cured by surgery including cervical cancer in situ, basal or squamous cell skin cancer, breast ductal carcinoma in situ, localized prostate cancer; 3. prior thoracic irradiation, chemotherapy, or lobectomy 4. known diseases or conditions that are contraindicated for radiotherapy or surgery; 5. allergy to the research medications; 6. pregnant women or women preparing for pregnancy; 7. diagnosis of autoimmune disease or history of chronic autoimmune disease 8. absence of informed consent because of psychological, family, social and other factors; 9. patients with comorbidities (chronic pulmonary disease, poorly controlled hypertension, unstable angina, myocardial infarction within 6 months, unstable mental disorders requiring therapy).

Keywords: esophageal cancer chemoradiotherapy immunotherapy chemotherapy
magnitude, types, and associated factors of external abdominal hernias among adult patients visiting the surgical outpatient department at hiwotfana comprehensive specialized hospital and jugol regional hospital, eastern ethiopia: a cross-sectional study

Conditions: Abdominal Wall Hernia

Summary: the study was aimed at determining the magnitude, types, and associated factors of external abdominal hernia among adult patients visiting the outpatient department at the hiwot fana comprehensive specialized hospital (hfcsh) and jugol regional hospital in eastern ethiopia.

a cross-sectional study was carried out from september 20 to december 5, 2022, on adult patients who visited the surgical outpatient department at the hiwotfana comprehensive specialized hospital and jugol regional hospital in eastern ethiopia. all adult patients who visited the surgical outpatient department of each hospital were enrolled in the study using a systematic random sampling technique with skipping intervals of two until the calculated sample size was obtained, which is 403. data collection was accomplished through medical record reviews of patients and face-to-face interviews. the data were analyzed by the statistical package for social science version 26 software. both descriptive and inferential statistics were conducted, and the results were presented in text, graphs, and tables. a chi-square test was calculated, and an odds ratio for the strength and directions of association was used with a 95% confidence interval and a p-value of \<0.05 to be considered statistical. this investigation determined the overall magnitude of external abdominal wall hernias in the study area as well as the types of external abdominal hernias. at the conclusion of the investigation, each significant associated factor for an external abdominal hernia was identified.

Eligibility criteria:
inclusion criteria: * all adult individuals who visited the surgical outpatient department during the period of study exclusion criteria: * patients who were unable to respond due to severe illness or mental health problems
comparison between sensory and motor transcutaneous electrical nervous stimulation on electromyographic and kinesiographic activity of patients with temporomandibular disorder: a controlled clinical trial

Conditions: Temporomandibular Disorders

Summary: background the purpose of the present controlled clinical trial was to assess the effect of a single 60 min application of transcutaneous electrical nervous stimulation (tens) at sensory stimulation threshold (sts), compared to the application of motor stimulation threshold (mts) as well as to untreatment, on the surface electromyographic (semg) and kinesiographic activity of patients with temporomandibular disorder (tmd). methods sixty female subjects, selected according to the inclusion/exclusion criteria, suffering from unilateral tmd in remission were assigned to mts, sts or untreatment. pre- and post-treatment differences in the semg activity of temporalis anterior (ta), masseter (mm), digastric (da) and sternocleidomastoid muscles (scm), as well in the interocclusal distance (id), within group were tested using the wilcoxon test, while differences among groups were assessed by kruskal-wallis test; the level of significance was set at p ≤ 0.01.


Eligibility criteria:
inclusion criteria: * age less than 30 years; * female gender * right-handed (7-10 points in edinburgh inventory); * presence of complete permanent dentition, with the exception of the third molars; * normal occlusion; * diagnosis of unilateral arthrogenous tmd on the research diagnostic criteria for tmd (rdc/tmd), axis i, groups ii and iii exclusion criteria: * having pacemaker or other electrical devices * previous experience of tens or biofeedback * systemic diseases * history of local or general trauma * neurological or psychiatric disorders * muscular diseases * cervical pain * bruxism diagnosed by the presence of parafunctional facets and/or anamnesis of parafunctional tooth clenching and/or grinding * pregnancy * assumption of anti-inflammatory, analgesic, antidepressant or myorelaxant drugs * fixed or removable prostheses * fixed restorations that affected the occlusal surfaces * previous or concurrent orthodontic or orthognathic treatment
biportal endoscopy spine surgery (bess )versus unilateral laminotomy bilateral decompression (ulbd ): rct, non-inferiority trial

Conditions: Degenerative Lumbar Spinal Stenosis

Summary: this study is to compare the clinical outcome between the biportal endoscopic decompression and the unilateral approach bilateral decompression in spinal stenosis


Eligibility criteria:
inclusion criteria: * patients aged between 30 and 80 * patients who has radiating pain (vas \>=40) on lower extremities with spinal stenosis over gr b * patients who required one-level decompression between l1 and s1 * those who (only if a signature was obtainable), or whose legal guardian, fully understood the clinical trial details and signed the informed consent form exclusion criteria: * revision surgery * over spondylolisthesis gr ii * degenerative lumbar scoliosis (cobb angle \>20) * herniated disc * patients with a history of other spinal diseases (compression fracture, spondylitis, tumor) * women with positive pregnancy tests before the trial or who planned to become pregnant within the following 3 years * patients with a history of malignant tumor or malignant diseases (but the cases of cured disease with no relapse for the past 5 years were included in the present study) * patients with mental retardation or whose parents or legal guardians were older or had mental disabilities * other patients viewed as inappropriate by the staff
relationship between hand dynamometer measurements, pft, and mfi with postoperative outcomes

Conditions: Complication,Postoperative; Lung Cancer

Summary: the study will take place at sbü ankara atatürk sanatorium training and research hospital and will include 100 patients over the age of 40 who are scheduled for lung malignancy surgery after 01 april 2024. informed consent will be obtained from all patients, who will be assigned a number from 1 to 100. for patients over 40 years of age who are scheduled to undergo lung malignancy resection surgery, demographic data including age, gender, height, weight, body mass index (bmi), diagnosis, comorbidities, and asa (american society of anaesthesiologist) score will be recorded. in addition, hand grip strength measurement, pulmonary function test, and modified frailty index (a scoring system that includes 11 parameters) will be recorded prior to surgery. intraoperative and postoperative complications will be documented. the duration of the patient's stay in the intensive care unit, chest tube removal, length of hospital stay, and postoperative complications will also be recorded. a follow-up call will be made to the patient by the responsible researcher 90 days after the operation to inquire about any complications that may have developed within that time frame. the study aims to investigate the relationship between preoperative hand grip strength measurement, pulmonary function test analysis (pft), and modified frailty index with the duration of intensive care unit stay, chest tube withdrawal time, hospital stay, and postoperative complications in patients undergoing lung resection due to malignancy.


Eligibility criteria:
inclusion criteria: * all patients over the age of 40 who will undergo lung resection due to malignancy exclusion criteria: * patients undergoing emergency surgery * patients with missing preoperative measurements * patients with missing 90-day follow-up data

Keywords: lung cancer postoperative complication modified frailty index pulmonary function test hand grip strength measurement
using ivr to maintain acs patients on best practice guidelines

Conditions: Acute Coronary Syndrome; Medication Adherence

Summary: the purpose of this study is to determine whether interactive voice response (ivr) technology can be used to bring post discharge care for acute coronary syndrome (acs) closer to best practice guidelines (bpgs). the study hypothesis is that acs patients who are contacted by ivr technology will be more likely to receive care as recommended in the bpgs than those followed by usual care.

acute coronary syndrome (acs) is a significant public-health problem in canada and worldwide with 20,000 canadians dying of myocardial infarction and 42,000 dying of coronary artery disease in 1999. large clinical trials have provided evidence for the development of standardized best practice guidelines (bpg) and compliance with these guidelines have significantly improved survival. despite the development and dissemination of bpg, their application in patients with acs is suboptimal. this randomized control trial will use 2 groups: ivr and usual care. patients in the ivr group will receive 5 automated calls at 1,3,6,9 and 12 months consisting of predetermined questions related to medication management, smoking cessation, diet, exercise and education as recommended by the acc/aha bpg for acs. responses are captured in a database allowing for interventions to maintain patients on bpg as needed.

Eligibility criteria:
inclusion criteria: * patients discharged from lhsc with acs (acute myocardial infarction, stemi, nstemi or unstable angina) * patients who have a land line telephone service at home * patients who speak english exclusion criteria: * patients discharged to a care facility or transferred to another health care institution * patients who cannot provide informed consent

Keywords: acute coronary syndrome interactive voice response technology best practice guidelines compliance health care utilization