Kornimate/medical-research-clean huggingface dataset:
contrast echocardiography in patients with pulmonary arteriovenous malformations (pavms)

Conditions: Pulmonary Arteriovenous Malformations

Summary: pulmonary arteriovenous malformations (pavms) are thin-walled abnormal vessels which provide direct capillary-free communications between the pulmonary and systemic circulations. patients with pavms have usually have low blood oxygen levels and are at risk of other complications including strokes, brain abscesses, pregnancy-related complications and haemorrhage. we hypothesise that the complications of pavm patients arise from their pavms and not the more recognised intracardiac forms of shunting. we propose to perform echocardiograms to enable assessment of the presence of other causes of capillary-free communications between the pulmonary and systemic circulations.


Eligibility criteria:
inclusion criteria: * patients with pulmonary arteriovenous malformations (pavms) exclusion criteria: * unable to provide informed consent
the effects of oxytocin on startle hyperreactivity in patients with aud and ptsd

Conditions: Stress Disorders, Post-Traumatic; Alcoholism

Summary: this study will investigate the effects of oxytocin on alcohol-related behaviors, social abilities, and physiological startle responses in healthy individuals and patients with posttraumatic stress disorder (ptsd) and alcohol use disorder (aud) using a randomized, placebo-controlled, dose-tiered, between-subject study design. specifically, the investigators will determine if intranasal administration of a single dose of the pro-social neuropeptide oxytocin decreases alcohol-related approach bias and cravings, enhances social abilities, and decreases physiological hyperactivity. the investigators will also determine the optimal dose to achieve these effects and will explore psychosocial predictors of responses to oxytocin. the proposed work has the potential to yield a novel pharmacological treatment for aud and ptsd, both leading causes of disability in the us military for which currently available treatments are inadequate.


Eligibility criteria:
inclusion criteria: 1. ages 18 to 75 (inclusive) 2. current dsm-v diagnosis of ptsd 3. current (past month) dsm-v diagnosis of a moderate to severe alcohol use disorder exclusion criteria: 1. current or lifetime psychotic disorders, such as schizophrenia or bipolar disorder 2. dementia or other neuropsychiatric disorders involving cognitive deficits or active symptoms impairing their ability to complete study tasks. 3. subjects known to have clinically significant unstable medical conditions, including but not limited to clinically significant renal disease. 4. use of disulfiram, naltrexone, or acamprosate for alcohol use disorder in the past week. 5. needing acute medical detoxification from alcohol based on a score of 12 or more on the clinical institute withdrawal assessment of alcohol scale (ciwa-ad); 6. subjects who are legally mandated to participate in an alcohol treatment program. 7. subjects who have had a suicide attempt in the past 6 months or suicidal ideation in the 90 days prior to enrollment. 8. subjects with seizure disorders that require anticonvulsant medications 9. positive urine pregnancy test, women meeting dsm-v criteria for premenstrual dysphoric disorder or with diseases likely to influence hormonal or neuroendocrine status 10. sensitivity to preservatives (in particular e 216, e 218 and chlorobutanol hemihydrate) 11. nasal obstruction, discharge, or bleeding 12. taking testosterone or estrogen/progesterone supplement, or 5ht1a agonists/antagonists, as these agents can alter oxytocin levels

Keywords: oxytocin ptsd alcohol use disorder social cognition craving fear-potentiated startle
the acs ethnicity platelet function study

Conditions: Acute Coronary Syndrome

Summary: this study is being done to assess the effects of the ctp inhibitor on the function of your platelets (cells within your blood that are involved in the formation of blood clots) and to assess whether you have responded to the ticagrelor well enough to prevent the formation of blood clots within the stent or site in which angioplasty was performed. recent studies have looked at how racial differences can affect platelet reactivity, the way blood clots. but these studies have not looked at the way different racial backgrounds can affect the way the blood forms clots. minorities, such as african-americans are underrepresented. therefore, we are conducting this platelet reactivity study to better understand if there are differences in how this drug affects african-americans from how they affect caucasian patients undergoing percutaneous coronary intervention and receiving ticagrelor. these data will be compared to a historical control of caucasian patients who underwent similar platelet function testing.


Eligibility criteria:
inclusion criteria: * female (post menopausal or surgically sterile) and/or male aged 18 years or older * presenting with acs fulfilling the following: 1. symptoms or new ecg changes (st segment elevation or depression of at least 1 mm in 2 or more contiguous leads on ekg) 2. elevation of biomarkers (ck-mb ≥2 uln or troponin ≥ uln) * self-identified as african-american * treatment with 75-100mg asa daily exclusion criteria: * any indication (atrial fibrillation, mitral stenosis or prosthetic heart valve, pe, dvt) for antithrombotic treatment during study period. * fibrinolytic therapy within 48 hours before randomization * concomitant therapy with a drug having possible interaction with ticagrelor. (concomitant therapy with a strong cytochrome p-450 3a inhibitor or inducer) * increased bleeding risk including: recent (\ 180mmhg or diastolic blood pressure \[dbp\]\>100mmhg), history of hemorrhagic disorders that can increase the risk of bleeding, platelet count less than 100,000 mm3 or hemoglobin \<10 g/dl. * any history of hemorrhagic stroke. * contraindication or other reason that asa or ticagrelor should not be administered (e.g., hypersensitivity, active bleeding, major surgery within 30 days of dosing). * severe renal failure (creatinine clearance \<30ml/min or patient requires dialysis) * history of moderate or severe hepatic impairment with aspartate amino transferace, alanine amino transferase or total bilirubin \> 1.5 x upper limit of the reference range. * pregnant or lactating women. * patients receiving any glycoprotein iib/iiia inhibitors \<8 hours before platelet reactivity testing.
quantification of micro-rna 146-a in chronic periodontitis and coronary heart disease subjects

Conditions: Periodontal Diseases; Coronary Disease

Summary: the expression and quantification of micro-rna 146-a, was analyzed in the subgingival plaque samples of generalized chronic periodontitis patients with and without coronary heart disease. the demographic variables and periodontal parameters were assessed and correlated with expression of micro-rna 146-a. the quantification of levels of micro-rna 146-a was done using real time polymerase chain reaction. ( rt-pcr)

the quantification of the levels of microrna 146-a was analyzed in subgingival plaque samples of generalized chronic periodontitis subjects with and without coronary heart disease and compared them with the healthy subject.a total of 90 subjects were selected for the study and assigned to 3 groups based on inclusion and exclusion criteria. group i comprised of 30 subjects with generalized chronic periodontitis diagnosed with coronary heart disease.group ii comprised of 30 subjects with generalized chronic periodontitis without coronary heart disease and group iii comprised of 30 systemically healthy volunteers with no chronic periodontitis or coronary heart disease. demographic variables such as age, weight,height,bmi and income and clinical parameters such as plaque index, bleeding on probing, probing pocket depth and clinical attachement levels were recorded. subgingival plaque samples were collected from all the 3 groups. the collected samples were subject to further molecular analysis for micro-rna expression and quantification using rt-pcr.

Eligibility criteria:
inclusion criteria: 1. patients willing to participate in the study. 2. patients within the age group of 35-65 years. 3. should have ≥ 10 natural teeth. 4. for group i generalized chronic periodontitis patients with coronary heart disease: generalised chronic periodontitis is defined as those having 30% or more sites with clinical attachment loss (cal) ≥ 3mm. 5. for group ii generalized chronic periodontitis patients without coronary heart disease. 6. healthy controls were selected based on the following criteria: probing pocket depth (pd) less than 4mm, bleeding on probing (bop) at ≤15% of tooth sides, and no periodontal treatment (scaling and root planning or periodontal surgery) within the previous six months. exclusion criteria: 1. patients with systemic conditions such as type i, type ii and pre diabetes mellitus, respiratory diseases, renal disease, liver disease, collagenosis, rheumatoid arthritis, allergy, advanced malignancies and hiv infection were excluded from the present investigation. 2. use of drugs such as corticosteroids, antibiotics within 6 month of investigation and immuno-suppressive chemotherapy. 3. smokers and other behavioural factors which may influence the study. 4. patients who had undergone periodontal therapy within the previous 6 months. 5. female patients (due to hormonal changes and pregnancy which may alter the oral flora).

Keywords: micro-rna chronic periodontitis
study the effect of acupuncture on migraine patient without aura via functional magnetic resonance imaging.

Conditions: Migraine Without Aura

Summary: this study recruits 30 subjects into three groups, including two experimental groups and one control group. the two experimental groups receive acupuncture treatment for 4 weeks and two times functional magnetic resonance imaging scans as well as clinical symptom assessments. the control group receive one scan without any intervention. the aim of this study is to find the whether the effect of acupuncture treatment have diversity among migraineurs with different disease course.

this study recruits 10 patients with long course (\> 5 years) without aura migraine, 10 patients with short course (\< 5 years) without aura migraine and 10 healthy volunteers who meet the inclusion and exclusion criteria. among the study, two migraine patient groups receive acupuncture treatment for 4 weeks, the frequency is 30 minutes each time, three times a week. according to the national standard of the people's republic of china (gb / t 12346-2006) acupoint name and location, the acupuncture treatment includes sj23 (si zhu kong, unilateral), gb8 (shuai gu, unilateral), ex-hn5 (tai yang, unilateral), gb20 (feng chi, unilateral), li4 (he gu, bilateral), gb41 (zu lin qi, bilateral), gb34 (yang ling quan, bilateral) and sj5 (wai guan, bilateral) acupoints. both migraine patients receive scan in functional magnetic resonance imaging (siemens 3.0t superconducting magnetic resonance scanner, germany) and symptom scale assessment before the first acupuncture stimulation and post the last acupuncture stimulation. healthy volunteers receive only one scanning without intervention.

Eligibility criteria:
inclusion criteria: * fitting to the standard of migraine without aura in the international classification of headache disease (ichd-2) issued by the international headache society in 2004. * age from 18 to 55, male or female, with right-handedness. * having no depression or other serious mental illness. * having no psychoactive drugs taken in the past 3 months, or vasoactive drugs in the past 2 weeks. * having no habit of taking analgesics from a long time. exclusion criteria: * having the first headache attack of migraine after 55 years old. * having a history of head injury, cluster headache, or other unclassified headaches. * taking medicine to prevent migraine in recent 4 weeks. * having the serious asymmetry or definite pathological changes in the anatomical structure of the head through the mri scan. * cannot hold on the times of the mri scan.

Keywords: acupuncture functional magnetic resonance imaging
personalized behavioral nutrition intervention in older aas with t2d

Conditions: Type 2 Diabetes

Summary: the rapid growth rate and unique challenges as a new immigrant group call for a better understanding of the social and health needs of the older asian americans (aas) population. overwhelming numbers of aas, a fast-growing first-generation immigrant group, suffer from type 2 diabetes (t2d) and its consequences of poorly controlled blood glucose. for the older aas, there are higher prevalence rates, worse diabetes control, and higher rates of complications due to limited english proficiency and health literacy. despite the evidence concerning the effects of dietary interventions on glycemic control by well-controlled feeding studies in mainstream americans, a lack of clinical trials of culturally tailored interventions often imposes serious barriers to translate and implement such fruitful and innovative approaches in individuals from ethnic minority communities such as aas. the proposed study will use a randomized, controlled design with a sample of 60 aas aged 65 years or older. metabolomics methodologies will be incorporated into this research to provide a global picture of metabolites' responses to personalized behavioral nutrition (pbn) intervention. the study results will obtain the necessary information to conduct a meaningful community-based clinical trial to test the effectiveness of pbn in improving dietary patterns and glycemic control in older aas.

this study is designed with two aims: 1. to determine if pbn intervention improves glycemic control, weight control, and metabolites profiles compared with the control group. 2. to identify significant factors that influence the relative effectiveness of pbn and the relative acceptability of pbn.

Eligibility criteria:
inclusion criteria: 1. self-identified as asian americans (chinese, korean, or south asian) 2. age 65 years or older 3. residing in the bexar county area 4. diagnosed with type 2 diabetes; a1c ≥7.5% within 6 months of screening 5. expressing a willingness to participate in all aspects of the study over its full course 6. possession of a smartphone exclusion criteria: 1. unable to give informed consent 2. people under another diet regime that is different from the ada recommended diet 3. physical or mental health conditions that could limit active participation in the study (e.g., severe illness, blindness in both eyes, severe immobility, psychiatric diseases) 4. hematological condition that would affect a1c assay, e.g., hemolytic anemia, sickle cell anemia

Keywords: personalized behavioral nutrition pilot study hybrid randomized clinical trial older asian americans metabolomics approach
the prognostic value of fdg pet/ct and diffusion-weighed imaging on breast cancer

Conditions: Breast Neoplasms

Summary: the purpose of this study is to determine findings of positron emission tomography and diffusion weighted magnetic resonance in primary lesion and axillary metastasis of breast cancer and compare of two imaging modality in these patients.

we aimed that to correlate both primary lesion 18f-fluorodeoxyglucose (fdg) maximum standardized uptake value (suvmax) and diffusion-weighted imaging (dwi) apparent diffusion coefficient (adc) with clinicopathological prognostic factors and compare the prognostic value of these indexes in breast cancer in this study. the evaluated and compared parameters are suvmax and adc according to age, tumour size, lymph node metastasis, receptor status, histologic grade, modified nottingham prognostic index.

Eligibility criteria:
inclusion criteria: * newly diagnosis of breast cancer for which surgical intervention is planned exclusion criteria: * patients received neoadjuvant chemotherapy * before breast surgery

Keywords: breast neoplasms positron-emission tomography diffusion magnetic resonance imaging
integrated whole-genome analysis of hematologic disorders

Conditions: Hematologic Diseases

Summary: we will use new technologies to look at the dna, rna, proteins, and metabolites in the disease-containing blood, bone marrow, or tissue and normal cells from the skin. our goal is to analyze all of the genes in the diseased and normal skin sample. by comparing the results of the diseased sample and normal skin cells and the results of the two types of genetic information (dna and rna), we should be able to identify genetic changes that are important for the initiation, progression, or treatment response of that particular disorder.


Eligibility criteria:
inclusion criteria: 1. 18 years of age or older 2. patient meets the clinical and/or pathologic criteria for the hematologic disorder being examined. 3. patient is willing to provide a skin biopsy and five 10 ml tubes of peripheral blood. exclusion criteria: 1. less than 18 years of age 2. patient is not willing to provide a skin biopsy and five 10 ml tubes of peripheral blood.
necrotizing enterocolitis (nec) surgical database

Conditions: Necrotizing Enterocolitis

Summary: the general objectives of this protocol are to develop a multi-center prospective data collection process to identify risk factors for progression of necrotizing enterocolitis (nec). these data will be used as a basis for identifying management strategies appropriate for further evaluation (randomized controlled trials), to develop evidence-based standards of care, and as a tool to facilitate quality-assessment at individual centers through comparison of outcomes with the entire database.


Eligibility criteria:
inclusion criteria: patients must meet at least one criterion from each of the following three categories: historical factors: * feeding intolerance defined as vomiting of 2 or more feedings within 24 hours or any vomitus containing bile, or the presence of gastric residuals of volume greater than 6cc/kg or any aspirate containing bile * apneic/bradycardic episodes * oxygen desaturation episode not otherwise explained * guaiac positive or grossly bloody stools physical examination findings: * abdominal distention recorded by practitioner * capillary refill time greater than 2 seconds * abdominal wall discoloration * abdominal tenderness radiographic findings: * pneumatosis intestinalis * portal venous gas * ileus * dilated bowel * pneumoperitoneum * air/fluid levels * thickened bowel walls * ascites or peritoneal fluid * free intraperitoneal air exclusion criteria: patients will be excluded for any of the following: * major gastrointestinal anomaly * prior abdominal operation * family does not consent to participate (a list of patients for whom consent was refused will be maintained in order to avoid contacting these families repeatedly. all families who refuse consent will be queried as to the reason for refusal).

Keywords: necrotizing enterocolitis
exploration by uhf mri of hypothalamic networks associated to feeding in obesity and anorexia

Conditions: Eating Disorders

Summary: food intake is a motivated behaviour that consists of seeking, selecting and ingesting nutritional resources from the environment. its main function is therefore, depending on these conditions, to ensure the supply, in adequate quantities, of the energy and biochemical substrates necessary for the proper functioning and need of the body. thus, in addition to maintaining the body's fat mass level stable, dietary behaviour is part of the energy homeostasis system and is thus regulated and maintained by the central nervous system. although diet regulation involves several brain regions, the way in which these different regions communicate with each other and influence each other to orchestrate appropriate eating behaviour is not yet fully characterized. among the structures of this network, the hypothalamus, a small structure (less than 1 cm3 in humans) composed of several nuclei such as the lateral hypothalamus, the arched nucleus or the lateral tuberal nucleus plays a crucial role. the investigators propose to use ultra high field (7t) magnetic resonance imaging equiping the cemerem (chu timone, aphm, marseille) to better characterize the role of this crucial small structure in food intake networks in order to better understand the impact of these structural and functional disorders observed in patients with anorexia nervosa and obesity compared to a control population without eating behaviour disorders.


Eligibility criteria:
inclusion criteria: * no depression (hads and beck scores) * no contraindication to 7t mri * subject with with social insurance * subject who has signed the informed consent for obese patients * body mass index \> 30kg/m2 * body diameter \< 60cm (compatible with 7t mr scanner tube) for anorexic patients * mental anorexia according to dms-v * body mass index \< 17kg/m2 for healthy controls * 18.5kg/m2\<body mass index \< 25kg/m2 * no feeding behavioral disturbance (scoff and eat 26) exclusion criteria: * pregnant or parturiente woman * subject with other neurological or neuropsychiatric diseases * subject with addiction
the effect of ankle taping and balance exercises on postural stability

Conditions: Disturbance; Balance, Labyrinth; Proprioceptive Disorders

Summary: both taping and balance exercises have effects on dynamic balance, so this study compared ankle taping and balance exercise on postural stability indices in healthy women. we hypothesized that both balance exercise and taping would increase stability indices but the effects of balance exercise was more greater than taping.

the ability to control the body in the space is a complex interaction between musculoskeletal and neural systems. this set is called postural control system. postural control involves the control of body position in space for the dual purposes of postural stability and postural orientation. balance process is divided into four-stage by sullivan and markos: mobility, stability, controlled mobility, and skill. several types of exercise have been proposed to improve proprioception. bout and gahery stated that balance exercises improve neuromuscular relations and reduces the proprioception errors. they believe that those who have more proprioception difficulty may benefit more from exercise therapy.taping is another technique to enhance proprioception. improvement in proprioception leads to better function and reduction of disability. kinesiotaping is being used to prevent injuries and to help curing the injury. it can also improve efficiency in sport, improve lymph and venous circulation, decrease edema, stimulate the mechanoreceptors and increase awareness of subject about the ankle position, reduces the pain and improves muscle performance

Eligibility criteria:
inclusion criteria: * having no pain in ankle joint, not having sport activity in the period of this study, healthy sensory motor function in lower limb, no history of neuromuscular disease, vertigo or any uncorrected visual problems, any kind of ankle injury or lower limb surgery, taking sedative medication, cardiovascular, neurologic, and pulmonary disease, balance problems, rheumatoid disease, psychological disease, body mass index between 17 to25. exclusion criteria: * ankle pain, allergy to tape, and not completing all interventional sessions.

Keywords: balance exercise ankle postural stability taping biodex