Kornimate/medical-research-clean huggingface dataset:
how nava works in preterm infants with irregular respiratory efforts

Conditions: Premature Infants; Neurally Adjusted Ventilatory Assist; Ventilator Lung; Newborn; Mechanical Ventilation

Summary: for the infant participating the study, ventilator settings and respiratory variables will be recorded every day and exported to a specific computer using the servo record viewer version 1.0 (maquet critical care ab, getinge, gothenburg, sweden). collected data gives the value for peak inspiratory pressure (pip), expiratory tidal volume (vt), peak edi, minimum edi, measured respiratory rate (rr), neural respiratory rate (nrr) and percentage of backup breaths for each minute. all the ventilator data will be inspected and compared with the event logs recorded automatically from the ventilator, which includes all the alarm notification, mode and setting changes, cables connection and disconnection data. data during disconnection of the edi cable, malfunction or dislocation of edi catheter will be excluded from the analysis. the mean values during each day will be computed for each ventilatory variables. if there is a change in the ventilatory setting parameters, we will choose the one which was applied for longer duration in the 24-hour time period. the following clinical characteristics will be collected from medical records: gestational age at birth, birth weight, gender, the time and amount of feeding, medication during the study days, desaturation events, bradycardia events, suction time and methods.


Eligibility criteria:
inclusion criteria: * babies who receiving respiratory support with neurally adjusted ventilatory assist * babies with informed consents from their parents exclusion criteria: * babies using anesthetic agents
pet / ct with 18f-fdg: does it optimize the i 123-mibg imaging results in the search for discriminating factors for the implementation of an implantable defibrillator?

Conditions: Defibrillators, Implantable

Summary: the main objective of this study is to determine among the patients included a subpopulation that does not need a defibrillator. this will be done by comparing the number of discordant segments (mismatch) between patients who have a severe arrhythmia (ventricular tachycardia or ventricular fibrillation) with appropriate electrical therapy within 3 years of monitoring and others. "mismatch" in the definition of this objective is the usual definition: score 3.4 in i123-mibg (iodine 123 metaiodobenzylguanidine) and pet at 0,1,2.


Eligibility criteria:
inclusion criteria: * patient with ischemic heart disease with heart failure * patients who received myocardial perfusion scintigraphy * indication for the implantation of an icd installed according to current recommendations : lvef \<30% and nyha (new york heart association) stage ii, iii. * the subject must have given his informed consent and signed consent * the subject must be a member or beneficiary of a social security system exclusion criteria: * pregnant or lactating women * history of "open heart" cardiovascular surgery * inability to sign informed consent (patient under guardianship) * patients with diabetes mellitus * patient with proven dementia * person refusing to sign the consent * someone who already has an icd at baseline * life expectancy less than one year (nyha iv, other diseases such as neoplastic disease in an advanced stage)
effect of low-level laser on pain and healing of donor site following free gingival graft

Conditions: Gingival Recession

Summary: the aim of this randomized split-mouth design clinical trial is to clinically evaluate the effectiveness of diode laser in the healing of donor site of palate in free gingival graft.

free gingival graft is the most predictable and successful method for increasing the width of keratinized tissue around teeth/dental implants and vestibular deepening. however, patient discomfort during the healing time is a major disadvantage of this procedure. several methods have been introduced to accelerate the healing time and reduction of patient's pain during first days after surgery. low-level lasers have shown promising results in biostimulation of cell growth and differentiation in cultures. however, there are lack of well designed double blind placebo controlled randomized controlled clinical studies evaluating the effects of low-level laser therapy in acceleration of wound healing and pain relief of patients undergoing free gingival grafts.

Eligibility criteria:
inclusion criteria: * lack of keratinized tissue around teeth (bilateral) exclusion criteria: * patients with systemic diseases * non-cooperative patients * smokers * poor oral hygiene * root surface restorations or active caries

Keywords: wound healing low-level laser therapy gingival recession
the study to reevaluate the safety and efficacy of human urinary kallikrein

Conditions: Cerebral Infarction

Summary: in order to reevaluate safety and efficacy of human urinary kallikrein in treating acute cerebral infarction ,a multi-center, open label , single group study was designed. expect to enroll 60 sites and 2186 subjects. subjects will receive kallikrein treatment according to real clinical practice (suggest above 14days treatment) and 90 days follow up


Eligibility criteria:
inclusion criteria: 1. acute anterior circulation cerebral infarction diagnosed ≤ 48h; 2. first time diagnosed or have history of acute anterior circulation cerebral infarction without serious sequelae(mrs=0-2); 3. age from 18 to 80 years old; 4. national institute of health stroke scale(nihss) from 6 to 25; 5. have provided signed written informed consent from the patient or the patient's legal representative. exclusion criteria: 1. brain ct shows cerebral hemorrhage disease: cerebral hemorrhage, subarachnoid hemorrhage, etc. 2. transient ischemic attack(tia); 3. serious disturbance of consciousness: glasgow coma scalegcs（gcs）≤8; 4. combined angiotensin-converting enzyme inhibitor(acei) less than 5 half-time(according to its instruction), or need to be treated with acei; 5. cases treated with thrombolysis / stent surgery or expected to be treated with thrombolysis / interventional therapy / stent surgery. 6. subjects with bleeding disorders at past or present, laboratory tests: inr \> 1.5 or aptt \> 2 times; 7. subjects with abnormal liver function (alt/ast \> 1.5 \* uln) and abnormal renal function (cr\> normal upper limit); 8. subjects with history of epilepsy or other serious systemic disease before onset of ais refused by pi to enroll ; 9. subjects with cardiogenic stroke or cardiogenic stroke related high-risk factors identified by pi, such as atrial fibrillation, echocardiography or mural thrombus etc; 10. subjects diagnosised any malignancy (except basal cell carcinoma) within 5 years prior to the start of the study; 11. subjects with severe dementia or can't cooperate to evaluate identified by pi; 12. suffering from severe hypertension and failed to control :systolic blood pressure ≥200mmhg (26.6kpa) or diastolic blood pressure ≥110mmhg (14.6kpa); hypotension: systolic blood pressure\< 90mmhg and/or diastolic blood pressure\< 60mmhg 13. subjects be allergic or intolerant to kallikrein at past; 14. subjects be pregnant/lactating or possibly and planned pregnant; 15. subjects be unsuitable for this clinical study identified by pi.
colonoscopic removal of aberrant crypt foci: a prospective, randomized, blinded trial

Conditions: Colorectal Neoplasms

Summary: we hypothesized that aberrant crypt foci (acf) are precursors of colon cancer; their prevention would correlate with cancer risk and their elimination would reduce that risk. in this study we wished to (1) establish the feasibility of stain-enhanced magnification colonoscopy, (2) determine whether colorectal cancer is asociated with increased numbers of acf, and (3) investigate the natural history of acf and the durability of their elimination.

subjects are randomly assigned at the time of stain-enhanced magnification colonoscopy to have any acf removed or merely observed. subjects are evenly divided into those with and those without a personal history of colon cancer. acf are tabulated by an observer blinded to the subject's personal history. all subjects are then re-evaluated after one year by an observer blinded to the original procedure.

Eligibility criteria:
inclusion criteria: 1. dept.of defense healthcare beneficiaries 2. age 18 or over, non-pregnant 3. history of colorectal cancer or other indication for colonoscopic screening 4. at least half of large intestine remaining 5. no use of investigational or chemotherapeutic drugs within 6 mos. - exclusion criteria: 1. history suggesting familial colon cancer syndrome 2. \< 6 mos since colon resection or since treatment for colon cancer 3. anticipated colon surgery within one year of entry 4. inability to participate in scheduled followup at one year 5. medical or psychiatric condition which would make patient a poor candidate -

Keywords: human colonic aberrant crypt foci
enhanced recovery after surgery(eras) for gastric cancer and perioperative nutritional status

Conditions: Nutrition Disorders

Summary: this study is a prospective, single-center, randomized controlled trial. the study protocol was approved by the ethics committee at the first hospital of jilin university.the perioperation nutritional status will be assessed in gastric cancer patients within eras protocols.the eras patients were randomly divided into perioperational nutrition support group and conventional pathway group . inter-group differences were evaluated for nutritional index,clinical recovery index, complications etc.


Eligibility criteria:
inclusion criteria: * a preoperative cancer stage of t2, t3, t4, any n, m0 without digestive obstruction confirmed by whole body ct scan, which could be treated with laparoscopic gastrectomy; * age 18-75 years; * pathologic confirmation of gastric adenocarcinoma by endoscopic biopsy; * normal hematological, renal, hepatic, and cardiac parameters,american society of anesthesiology (asa) score \< iii without severe systemic disease; * no history of treatment with neoadjuvant chemotherapy and/or radiotherapy * pg-sga score ≥2，\<9 exclusion criteria: * patients requiring conversion to open gastrectomy * excessive bleeding (˃ 500 ml);and patients opting out of the study.

Keywords: gastric cancer enhanced recovery after surgery
using isosorbide mononitrate in reducing time in induction of labor in post date women

Conditions: Induction of Labor

Summary: we will compare between using isosorbide mononitrate together with misoprostol versus the misoprostol alone in induction of labor in postdate women


Eligibility criteria:
inclusion criteria: * age (20-35 yrs) * single fetus * gestational age \> 40weeks * not in labor * bishop score \< 7 * no medical disorder exclusion criteria: * gestational age ≤40 weeks * patient with a ripe cervix * rupture of membranes * suspected chorioamnionitis * placenta previa * history of major uterine surgery * hypertonic uterine pattern * contraindicated to receive pg * fetal malpresentation * multiple pregnancy * intrauterine growth retardation * women with any general medical disorder
comparing enoxaparin to fondaparinux to prevent venous thromboembolism (vte) in bariatric surgical patients

Conditions: Deep Venous Thrombosis; Pulmonary Embolism

Summary: this pilot study is designed to determine the feasibility of conducting a randomized clinical trial comparing fondaparinux sodium (arixtra) once daily with enoxaparin (lovenox®) twice daily with respect to preventing deep vein thrombosis (dvt) and pulmonary embolism (pe) after bariatric surgery in obese patients.

in order to determine the feasibility of such a trial we need to determine the necessary sample size. in order to determine the necessary sample size, we need to obtain estimates of the incidence of dvt and the prevalence of pe using mrv in each treatment group. descriptive statistics and 95% confidence intervals will be calculated to determine the incidence of dvt and the prevalence of pe using mrv in obese patients who have received treatment to prevent dvt and pe associated with bariatric surgery. anti-factor xa levels will be used to help determine if treatments are reaching appropriate levels.

Eligibility criteria:
inclusion criteria: 1. men or women 18 years or older. 2. body mass index (bmi) of 35kg/m2 or greater. 3. undergoing laparoscopic bariatric surgery, i.e., laparoscopic sleeve gastrectomy, laparoscopic roux-en y gastric bypass or laparoscopic duodenal switch. exclusion criteria: 1. history of previous deep vein thrombosis. 2. history of previous pulmonary emboli. 3. history of documented clotting/coagulation disorder. 4. history of cancer. 5. weight \ 200 kg or unable to fit in mri scanner. 6. presence of metallic foreign bodies 7. recent history of smoking (within the last year). 8. history of venous stasis disease. 9. history of obesity hypoventilation syndrome. 10. patients who are unable to lay flat for extended periods of time or are claustrophobic. 11. patients who have a pacemaker, an implanted defibrillator or certain other implanted or electronic or metallic devices (implanted medical or metallic devices, shrapnel, or metal). 12. history of hypersensitivity reaction to anticoagulation products. 13. history of hit (heparin induced thrombocytopenia. 14. history of renal insufficiency (creatinine clearance \< 50). 15. active clinically significant bleeding. 16. acute bacterial endocarditis. 17. bmi \> 60. 18. patients with metallic foreign body or implant (unable to have an mrv study).

Keywords: dvt pe mrv bariatric surgery
efficacy of intense pulsed light in the treatment of facial telangiectasia in systemic lupus erythematosus

Conditions: Facial Telangiectasia in Patients With Systemic Lupus Erythematosus

Summary: this clinical trial intends to evaluate the efficacy and safety of intense pulsed light (ipl) in the treatment of facial telangiectasia in patients with systemic lupus erythematosus (sle).

systemic lupus erythematosus (sle) is a chronic autoimmune disease that can involve multiple organs and systems. the treatment for sle mainly depends on long-term use of glucocorticoids. for many patients with sle, facial telangiectasia is a commonly seen side effect of long-term use of glucocorticoids. featured by facial erythema with or without flushing or burning sensation, facial telangiectasia seriously affects the quality of life of patients. however, up to now, there has been little attention paid to this condition in sle patients. there have been a lack of effective treatment options for tackling this problem. intense pulsed light (ipl) is a non-laser light source used to treat a variety of vascular and pigmented lesions. unlike ultraviolet that is harmful to patients with sle, application of ipl may be a safe and effective treatment for sle patients with facial telangiectasia. this study intends to evaluate the efficacy and safety of ipl in the treatment of facial telangiectasia for sle patients that has been treated with long-term corticosteroids.

Eligibility criteria:
inclusion criteria: * 1. age: between 18 and 65 years; 2. patients definitedly diagnosed with systemic lupus erythematosus according to "diagnostic criteria for systemic lupus erythematosus"; 3. patients receiving continuous treatment of glucocorticoid in the last 4 weeks. exclusion criteria: * 1. patients with severe diseases of heart, brain, lungs, liver, kidney, or blood system; 2. patients with drug abuse, alcohol abuse, or mental disorders that are unable to cooperate or adhere to treatment; 3. pregnant women, lactating women or women who are ready to conceive within 6 months; 4. participated in other clinical trials within 3 months before the screening.

Keywords: systemic lupus erythematosus intense pulsed light facial telangiectasia corticosteroids
development and evaluation of a virtual reality tool for at-risk trauma-exposed young people

Conditions: Substance Use Disorders; HIV Infections

Summary: this is a multi-phased study, funded through a national institute on drug abuse (nida) k24 grant that aims to ultimately refine a virtual reality tool through qualitative and quantitative research targeting hiv and substance abuse risk behavior among at-risk young people who have experienced psychosocial trauma. participants eligible for this study include young men who have sex with men (ymsm)/individuals who are romantically/physically attracted to men and adolescents with substance use disorder (sud) between the ages of 15 - 30 and have experienced at least one traumatic event in their lifetime. frontline healthcare workers who work within these populations are eligible for the study as well.

ymsm and adolescents with sud participants will complete 3 study sessions. during session 1, informed consent and baseline measures are administered. approximately one week later, during session 2, participants use and assess the virtual reality tool. approximately one week later, during session 3, baseline assessments are re-administered.

Eligibility criteria:
inclusion criteria for ymsm are as follows: * someone who identifies as a ymsm or identifies as someone with romantic or physical attraction to individuals who identify as men * is aged 15-30 years * have experienced at least one ite in lifetime (i.e., sexual assault, physical assault, witnessed domestic or community violence) * report being consensually sexually active or planning to become sexually active with a partner in the next 12 months * live in the charleston, sc/tri-county area inclusion criteria for adolescents with sud are as follows: * someone who reports using substances in the past year (for participants ages 15-17) or the past 6 months (for participants ages 18-30) * is aged 15-30 years * have experienced at least one ite in lifetime (i.e., sexual assault, physical assault, witnessed domestic or community violence) * report being consensually sexually active or planning to become sexually active with a partner in the next 12 months * live in the charleston, sc/tri-county area inclusion criteria for front line healthcare workers are as follows: * works directly with adolescents who have experienced ite and/or * works directly with adolescents or young adults with sud and/or * works directly with ymsm and/or * works directly with and/or adolescent or young adults who are hiv-positive exclusion criteria for all participants are as follows: * exhibits psychotic symptoms; * exhibits significant cognitive disability; * reports a history of pervasive developmental disorder; * has active suicidal or homicidal ideations * self-reports high levels of motion sickness

Keywords: substance use disorders alcohol use substance use hiv infections hiv risk virtual reality
effect of a rehabilitation program to improve quality of life in women diagnosed with endometriosis (physio-endea study)

Conditions: Endometriosis

Summary: given (1) the high volume of women on reproductive age that have a clinical diagnosis of endometriosis and (2) the poor management of symptoms that medical treatment usually achieves, new therapeutic interventions need to be evaluated in order to improve pain and quality of life in those patients. therefore, 'physio-endea' study has been designed to evaluate whether therapeutic exercise could help on the management of endometriosis-related symptoms

background: prevalence of endometriosis is approximately 10% of women of childbearing age. pain, considered in its multiple versions (dysmenorrhea, dyspareunia, dyschezia, dysuria and, in general, chronic pelvic pain) is the most common and disabilitating symptom in affected women. usual care, consisting on palliative pharmacological treatment in combination with surgery, is clearly insufficient and physical therapies need to be explored in order to reduce pain and to improve quality of life in affected women. objective: the overall objective of 'physio-endea' study will be to explore potential short and mid-term benefits of a rehabilitation program on the quality of life of symptomatic women. methods: a total of 26 symptomatic endometriosis women will be recruited. inclusion criteria includes: aged 18-50, clinical diagnosis of endometriosis and interested in improving lifestyle while exclusion criteria includes: diagnosed chronic disease or orthopaedic issues that would interfere with ability to participate in a physical activity program. women will be randomized to either intervention (n=13) or usual care group (n=13). intervention group will receive twice weekly session for 9 weeks and control group will receive recommendations about healthy lifestyle and usual care. discussion: this study attempts to improve the quality of life of symptomatic endometriosis women by reducing musculoskeletal and occupational impairments. findings will offer a new therapeutic approach for a better pain control.

Eligibility criteria:
inclusion criteria: * premenopausal status * clinical diagnosis of endometriosis by laparoscopy, magnetic resonance imaging or ultrasound imaging * history of clinical symptoms * to be able to walk without assistance * to be able to read and write enough * to be capable and willing to provide consent * interested in improving lifestyle exclusion criteria: * acute or terminal illness * presence of any chronic disease or orthopedic issues that would interfere with ability to participate in a physical activity program * unwillingness to complete the study requirements * be registered in other exercise program

Keywords: pain therapeutic exercise physiotherapy rehabilitation quality of life