Kornimate/medical-research-clean huggingface dataset:
pain pressure threshold in elbow pain

Conditions: Pain, Chronic; Elbow Disease

Summary: although validity and reliability studies have been completed in different patient groups in the literature, the validity and reliability of pressure pain threshold assessment in patients with elbow pain has not been studied. this study aims to study the validity and reliability of pressure pain threshold assessment in patients with elbow pain.

unidimensional and multidimensional scales based on patient reporting are mostly used in pain assessment. although determining pain severity based on patient reporting is important, the patient's physiological and psychological characteristics may make it difficult to interpret the responses. therefore, objective measurement of pain is very valuable in assessing health status. another approach to assessing variation in pain perception is to define pressure pain threshold. although validity and reliability studies have been completed in different patient groups in the literature, the validity and reliability of pressure pain threshold assessment in patients with elbow pain has not been studied. this study aims to study the validity and reliability of pressure pain threshold assessment in patients with elbow pain.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-65 years * having non-specific elbow joint pain that has been ongoing for the last 3 months * having the ability to read and write turkish * no vision or hearing problems * must have a level of cooperation that can comply with the evaluation exclusion criteria: * participated in a physiotherapy program due to elbow problem in the last 6 months * presence of neurological or cognitive impairment * fractures related to malignant conditions and/or elbow fractures * nerve injury, heterotopic ossification or myositis ossificans * having elbow arthrosis and/or elbow joint contracture * nonunion, malunion and infection problems * having complex regional pain syndrome * having any known rheumatological, cardiovascular, respiratory or psychiatric disease * having a skin disease that will affect the upper extremity evaluation
confocal endomicroscopy for permeability of esophageal wall in refractory gastroesophageal reflux disease (gerd)

Conditions: Gastro Esophageal Reflux; Barrett Esophagus; Erosive Esophagitis

Summary: confocal endomicroscopy for permeability of esophageal wall in refractory gastroesophageal reflux disease (gerd)


Eligibility criteria:
inclusion criteria: 1. age \> 18 years 2. ability to give informed consent exclusion criteria: 1. pregnancy 2. esophageal varices 3. prior esophageal or gastric surgery 4. active gastrointestinal bleeding 5. evidence of esophageal malignancy 6. inability to provide informed consent
mental health and cognitive dysfunction: a multicenter study at pediatric rehabilitation clinics in north norway

Conditions: Mental Disorders

Summary: patients referred to pediatric rehabilitation services have often cognitive deficits/intellectual disabilities.neurocognitive assessment is, hence, important when designing treatment plans. children and adolescents with cognitive deficits and intellectual disabilities (id) have a high risk of developing mental health problems. there is lack of knowledge about such comorbid mental disorders in the health service. there are also few validated instruments for assessing mental disorders among children and adolescents with cognitive deficits and id both in norway and abroad. the main aims of the current multicentre study are to: investigate psychometric properties of different psychiatric instruments for children and adolescents. investigate change and stability of symptoms over time. investigate user satisfaction. the study will include pediatric rehabilitation services at hospitals in tromsø, hammerfest and bodø and will include in total 320 patients aged 4 to 18. we will use information from parents, teachers and patients, in addition to clinician-rated measures. patients will be assessed at intake and after six months. we have conducted a pilot study in the period from 2012 to 2013.

1. investigate psychometric properties of a structured psychiatric interview (dawba) and a symptom measure (sdq) in clinical samples of children and adolescents with cognitive deficits and intellectual disabilities. we will investigate the instruments' reliability and convergent validity with the aberrant behavior checklist (abc), the dbc and the social responsiveness scale (srs), in addition to the clinician-rated severity of children's mental health problems measured with the cgas and honosca. 2. the psychiatric instruments will be administrated at intake and after six months. we will investigate prevalence rates and indicators of disorder severity (comorbidity and persistence), including risk factors (socioeconomic status, parenting styles). 3. investigate user satisfaction with the health service, i.e., the pediatric rehabilitation services.

Eligibility criteria:
inclusion criteria: 1. age from 4 years to 18 years 2. written informed consent to participate 3. fluent in norwegian 4. normal or corrected to normal vision and hearing - exclusion criteria: -
bladder washing cytology for detection of urothelial carcinoma using catheter or flexible cystoscope: which is better?

Conditions: Bladder Cancer

Summary: urine cytology can be collected with spontaneous urine or by washing the bladder. it is commonly accepted among urologist that instrumental bladder washing is the method of choice. there are, however, no solid recommendations regarding the method to collect the urine for bladder wash cytology during cystoscopy. there are mainly two possibilities: 1) the use of an intermittent bladder catheter after the removal of the cystoscope or 2) bladder lavage through working channel of the flexible cystoscope itself. the first choice may increase the number of collected cells because of the larger caliber of the catheter compared to the working channel and thus the better efficacy of bladder wash. however, this method is certainly more invasive and possibly more expensive. to the best of our knowledge and according to available literature, none of both collection method can be defined as gold standard. the aim of the study is to show that use of flexible cystoscope brings the same results in terms of quality of the urine collection for analysis as the use of intermittent bladder catheter and is less unpleasant for the patient. if our study confirms the non-inferiority of "direct" collection through the cystoscope, this will allow the establishment of recommendations in this sense in order to simplify the procedure and reduce as much as possible the manipulations within the urogenital tract.

the aim of the study is to show that use of flexible cystoscope brings the same results in terms of quality of the urine collection for analysis as the use of intermittent bladder catheter and is less unpleasant for the patient. group a: urinary cytology will be collected using a ch.14 bladder catheter after the removal of the cystoscope. catheter will be placed at the bladder neck level. group b: urinary cytology will be collected through the flexible cystoscope itself at the end the cystoscopy. before starting the urinary collection, the cystoscope will either be placed in front of a suspected intravesical lesion (if present) or at the bladder neck (if no lesion present).

Eligibility criteria:
inclusion criteria: 1. men aged \> or = 18 years 2. patients scheduled for a flexible cystoscopy and urinary cytology. 3. patients who have signed the informed consent. 4. patients who speak french exclusion criteria: 1. manipulations or instrumentation of urinary tract, including but not limited to double-j stent placement or removal, and/or bladder biopsy 2. inability to give informed consent or without capacity of discernment

Keywords: bladder cancer urinary cytology
long-term post thrombotic syndrome assessment (celest long term).

Conditions: Post Thrombotic Syndrome

Summary: the celest long term is a prospective study, assessing the very long term risk of post thrombotic syndrome (pts) in patients enrolled in the celest double-blind rct. all patients enrolled in celest rct will benefit from a 7-year follow-up visit conducted over the phone. the primary objective is to assess the proportion of patients with moderate-severe pts assessed with the patient reported villalta score and the 2 main secondary objectives are to assess predictors of moderate to severe pts and the impact of initial compression stockings strength (25mmhg vs. 35mmhg) on the development of moderate-severe pts. up to 288 patients may participate. the investigators believe that this study has the potential to significantly improve the knowledge on the epidemiology of burdensome pts and on the impact of different initial compression stockings strengths on the risk of pts.

the celest double blind rct demonstrated that 25mmhg elastic compression stockings (ecs) were non inferior to 35mmhg ecs to prevent post thrombotic syndrome (pts) 2 years after a first proximal deep vein thrombosis (dvt). likely because of lack of statistical power the investigators were not able to demonstrate that 25mmhg ecs were superior in the overall rct population and that 35mmhg ecs were superior in patients optimally adherent to ecs. furthermore, few data are available on the very long term (\>5 years). the celest long term is a prospective study, assessing the very long term risk of pts in patients enrolled in the celest rct. all patients enrolled in celest rct and willing to participate are eligible and will benefit from a 7-year follow-up visit conducted over the phone. primary objective is to assess the proportion of patients with moderate-severe pts defined as a patient reported villalta score (prvs) ≥10 or a venous leg ulcer ipsilateral to index dvt. secondary objectives include predictors of moderate to severe pts, impact of initial ecs strength on the development of moderate-severe pts, impact of anticoagulant treatment (type and duration) on the development of moderate to severe pts, proportion of pts (defined as prvs≥5 or ipsilateral leg ulcer) and impact of pts on patient's qol. study should last 1 year and up to 288 patients may participate. the investigators believe that this study has the potential to significantly improve the knowledge on the epidemiology of burdensome pts and on the impact of different initial ce strengths on the risk of pts.

Eligibility criteria:
inclusion criteria: * patients enrolled and followed in the celest rct\* exclusion criteria: * patients who withdrew consent or died during the 2-year follow-up of the celest rct. * patients who decline or are unable to participate (including severe memory loss issues) to the long-term follow-up * celest rct main inclusion/exclusion criteria were: adult (\>18 years at time of enrolment) patients first unilateral acute symptomatic proximal lower limb dvt

Keywords: post thrombotic syndrome elastic compression stockings long-term follow-up deep vein thrombosis
"multifactorial risk stratification in acute and chronic cardiovascular disease"

Conditions: Cardiovascular Diseases; Healthy

Summary: the aim of this study is to develop risk prediction models for the early detection of high-risk patients with structural, rhythmological or inflammatory cardiovascular diseases.


Eligibility criteria:
inclusion criteria: * decision-eligible male and female patients ≥18 years of age * acute or chronic condition due to structural, rhythmologic, or inflammatory cardiovascular disease * informed consent for participation in the clinical trial exclusion criteria: * missing infromed consent * pregnant or breast-feeding women
effectiveness of parent's manipulation in newborn with metatarsus adducts. a randomized controlled trial

Conditions: Foot Deformity Congenital

Summary: the purpose of this study is to determine whether the result of parent's feet manipulation compared with nonmanipulated group within first 6 months of life and observe spectrum of the disease within this period.

the newborn with metatarsus adducts are included in the study and divide in 2 groups by random.group a with parents'manipulation of the foot and group b without manipulation of the foot.the parents'foot manipulation is trained by pediatric orthopedic surgeons to correct the deformity.the effectiveness of the manipulation is measured by percentage of no deformity of the foot in newborn after 6 months.

Eligibility criteria:
inclusion criteria: * newborn with metatarsus adducts. exclusion criteria: * 1. criteria were included newborns with associated life threatening conditions. 2. congenital or musculoskeletal problems.(ie;arthrogryposis multiplex congenita,skeletal dysplasia) 3. mental retardation. 4. cognitive impairment. 5. parents incooperative. 6. difficult to follow up patients.

Keywords: newborn foot deformity congenital
il-7 receptor polymorphisms and immune recovery with haart

Conditions: HIV Infections

Summary: the aim is to investigate the hypothesis that il7-receptor polymorphisms contribute to the differential immune recovery of cd4 + t cells following haart

aim: to examine the association between the four haplotypes of il-7rα gene and a cohort of hiv infected patients who have commenced haart with varying cd4+ t lymphocyte responses. methods: il-7rα gene snps and haplotypes will be measured by constructing dna pools, and pcr amplification and dna sequencing. il-7rα expression will be examined using constitutive expression of il-7rα, il-7rα gene expression, and inducible expression of il7rα.

Eligibility criteria:
inclusion criteria: * men or women at least 18 years of age * first antiretroviral regimen composed of haart as defined by at least three antiretrovirals * controlled viremia for a period of at least 12 months following commencement of haart. controlled viremia is defined as hiv viral load of ≤ 500 copies/ml on bdna testing (versions 2 and 3) and \<400 copies/ml measured by rt-pcr assay by 6 months treatment. * cd4 cell count \<500 at commencement of haart * measurement of cd4+ cell count on at least 3 time points, in the 12 months post commencement of haart. exclusion criteria: * exclude patients treated for hiv seroconversion illness * exclude patients on immunomodulatory therapy such as il-2, hydroxyurea or prednisolone or who have received an hiv therapeutic vaccine

Keywords: treatment experienced hiv
a clinical outcome study of two multifocal intraocular lenses (iol) in cataract patients

Conditions: Cataracts

Summary: the purpose of this study is to compare acrysof® iq restor® +2.5 d multifocal iol in both eyes (bilateral implantation) to acrysof® iq restor® +2.5 d multifocal iol in the dominant eye with acrysof® iq restor® +3.0 d multifocal iol in the fellow eye (contralateral implantation) at month 3 following the second eye surgery.

each subject will complete a preoperative examination of both eyes, implantation of iol at the operative visit for each eye, and up to 4 postoperative visits (each eye examined at day 1-2, with binocular visits at day 30 and day 90 after the second implantation). the second implantation will occur between 1 and 45 days of the first. if the first eye is not implanted during surgery, the second eye is not eligible. lf both eyes are not implanted with the assigned iol, the subject will be followed for safety evaluation.

Eligibility criteria:
inclusion criteria: * willing and able to understand and sign informed consent, and attend postoperative examinations per protocol schedule; * requires cataract extraction followed by posterior intraocular lens implantation used as an on-label procedure in both eyes; * willing to have second eye surgery within 45 days of first eye surgery; * expected postoperative astigmatism \< 1.0 d in both eyes, as measured by keratometry; * free of severe diseases(s)/condition(s) listed in the warnings and precautions section of the package inserts; * other protocol-defined inclusion criteria may apply. exclusion criteria: * refractive lens exchange (monocular dcva of worse than 20/20, or ≥ 0.06 logmar). this exclusion did not apply to binocular (ou) measurement; * significant irregular corneal astigmatism as demonstrated by corneal topography; * severe degenerative visual disorders; * previous corneal surgery; * amblyopia; * planned multiple procedures, including lri, lasik, etc, during surgery or the course of the study; * history of corneal disease; * severe diabetic retinopathy; * history of retinal detachment; * severe conditions or acute or chronic diseases or illnesses that, per investigator's clinical judgment, would increase the operative risk or confound the results of the study; * pregnant or planning pregnancy during course of study; * other protocol-defined exclusion criteria may apply.

Keywords: intraocular lens multifocal intraocular lens (miol)
randomized fixed bearing vs mobile bearing cruciate substituting tka

Conditions: Osteoarthritis; Rheumatoid Arthritis; Other Inflammatory Arthritis; Post-Traumatic Arthritis; Juvenile Rheumatoid Arthritis; Avascular Necrosis

Summary: the study will evaluate the clinical performance of the rotating platform and fixed bearing implants through patient questionnaires, outcomes scoring and radiographic assessment.

the study will evaluate the clinical performance of rotating platform and fixed bearing cruciate ligament substituting implants by obtaining a series of primary tkas. patients will receive either the p.f.c.® sigma™ rotating platform cruciate substituting knee system or p.f.c.® sigma™ fixed cruciate substituting knee system and assignment is randomized.

Eligibility criteria:
inclusion criteria: * osteoarthritis * rheumatoid arthritis * other inflammatory arthritis * avascular necrosis (avn) of bone * post-traumatic arthritis * juvenile rheumatoid arthritis exclusion criteria: * history of recent/active joint sepsis. * charcot neuropathy. * psycho-social disorders that would limit rehabilitation. * greater than 75 years of age at the time of surgery. * prior ipsilateral knee arthroplasty. * metabolic disorders of calcified tissues, such as paget's disease. * severe diabetes mellitus. * joint replacement due to autoimmune disorders. * skeletal immaturity

Keywords: total knee replacement knee prosthesis
treatment of mood and marriage study (tomms)

Conditions: Major Depressive Disorder; Partner Relational Disorder (V61.10)

Summary: the primary goal of this study is to develop and test a depression-specific marital therapy tailored for use with older adult populations.

major depression has been associated with many individual and interpersonal problems in later life, including inadequate social support, marital distress, spousal depression, poor physical health, and higher rates of mortality. marital therapy has shown promise as a treatment for depression and coexisting marital distress in younger cohorts, and there is a robust association between social support and depressive symptoms in older adults. the combination of couple therapy and antidepressant medication may provide an ideal treatment for older adults by targeting interpersonal and biochemical aspects of depression. couples interested in this study will complete an initial assessment with study personnel. in phase i, eligible couples will receive weekly marital therapy and the depressed partner will receive medication management with a study doctor for 6 months. in phase ii, couples will be randomly assigned to either the combination treatment (marital therapy plus medication management) or medication management alone for 6 months. at the end of the treatment phase, a thorough assessment will be completed. a follow-up assessment will be completed 6 months after completion of treatment.

Eligibility criteria:
inclusion criteria: * one partner must receive a clinical diagnosis of major depressive disorder based upon our assessment * couples must be living together * either partner must report marital distress or tension * willing to take antidepressant medication and participate in weekly marital therapy and assessments * the depressed partner cannot be involved in any other psychosocial treatment * score above 24 on the mini mental status exam exclusion criteria: * both partners meet diagnostic criteria for major depressive disorder based on our evaluation * coexisting bipolar or psychotic disorder * evidence of a primary substance abuse or dependence disorder * current ect treatment * evidence of active and severe domestic violence

Keywords: older adults
incidence of pulmonary embolism during temporary pacing via femoral versus subclavian vein

Conditions: Pulmonary Embolism

Summary: temporary pacing via femoral vein is used widely in mainland china, because of its feasibility and simplicity. however, pulmonary embolism often occurred after the procedure. it is not known that whether there was any difference in incidence of pulmonary embolism between via different approaches. this randomized and multi-center study was designed to verify whether temporary pacing via subclavian vein has lower incidence than via femoral vein.


Eligibility criteria:
inclusion criteria: * 18 years old or older * there is indication for temporary pacing * patients agreed to participate in the clinical trial and sign a written informed consent exclusion criteria: * history of pulmonary embolism or deep vein thrombosis * devices existing in vein system * patients who could not receive randomization * severe coagulation disorder * severe liver, kidney dysfunction * mental diseases * pregnancy * patients investigators believed not suitable for enrollment

Keywords: pulmonary embolism temporary pacing femoral vein subclavian vein
a cross-sectional study on copd prevalence

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: chronic obstructive pulmonary disease (copd) is a major cause of morbidity and mortality worldwide and hence, estimating its prevalence is important. since 2007, there are few data on the prevalence of copd in the general population in spain. the main objective of this epidemiological observational study is to estimate the prevalence of copd in residents of spain among the population over 40 years of age. the subjects will be distributed in two groups depending on the presence and absence of copd. the study will have a single visit in which a brief interview will take place and subjects will need to complete the medical tests the case report form with a series of questionnaires. no drugs will be administered in this study.


Eligibility criteria:
inclusion criteria: * male and female subjects aged 40 years or older selected from the general population. * subjects who have provided oral consent to participate in the brief telephone interview; these subjects will need to sign the informed consent to continue participating in the study. exclusion criteria: * subjects with any physical or cognitive difficulties which will prevent them from participating in any of the study tests (example, spirometry and questionnaires). * subjects who are not located, dead or displaced.

Keywords: epi-scan-ii study copd epidemiology spain chronic obstructive pulmonary disease prevalence cross-sectional