Kornimate/medical-research-clean huggingface dataset:
study of aerobic training for people receiving chemotherapy for breast cancer

Conditions: Breast Cancer; Breast Carcinoma

Summary: in this study, investigators will compare standard aerobic training/at with adaptive aerobic training/at. standard at will be a fixed (unchanging) amount of walking each week, while adaptive at will adjust the level of exercise depending on participants' response to the exercise. investigators will see how both study approaches (standard at and adaptive at) affect participants' crf.


Eligibility criteria:
inclusion criteria: * aged ≥18 years * female * diagnosed with primary breast cancer as defined by one of the following: * histological confirmation * as per standard of care imaging * scheduled to receive neoadjuvant/adjuvant chemotherapy * performing ≤90 minutes of moderate- and/or strenuous-intensity exercise per week, as evaluated by self-report * willingness to comply with all study-related procedures * able to achieve an acceptable peak baseline cpet, as defined by any of the following criteria: 1. achieving a plateau in oxygen consumption, concurrent with an increase in power output; 2. a respiratory exchange ratio ≥ 1.10; 3. attainment of maximal predicted heart rate (hrmax) (i.e., within 10 bpm of age-predicted hrmax \[hrmax = 220-age\[years\]); 4. volitional exhaustion, as measured by a rating of perceived exertion (rpe) ≥ 18 on the borg scale. exclusion criteria: * enrollment onto any other interventional investigational study, except interventions determined by the pi not to confound study outcomes * receiving treatment for any other diagnosis of invasive cancer * distant metastatic malignancy of any kind * mental impairment leading to inability to cooperate * any of the following contraindications to cardiopulmonary exercise testing: i. acute myocardial infarction within 3-5 days of any planned study procedures; ii. unstable angina; iii. uncontrolled arrhythmia causing symptoms or hemodynamic compromise; iv. recurrent syncope; v. active endocarditis; vi. acute myocarditis or pericarditis; vii. symptomatic severe aortic stenosis; viii. uncontrolled heart failure; ix. acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures; x. thrombosis of lower extremities; xi. suspected dissecting aneurysm; xii. uncontrolled asthma; xiii. pulmonary edema; xiv. respiratory failure; xv. acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis) xvi. room air desaturation at rest ≤ 85% * any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation

Keywords: breast cancer breast carcinoma primary breast cancer aerobic training 22-364 memorial sloan kettering cancer center
brow enhancement study

Conditions: Brow Ptosis

Summary: investigation into brow aesthetics using botox in conjunction with juvederm xc as evaluated by patient satisfaction


Eligibility criteria:
inclusion criteria: * men and women exclusion criteria: * persons who have not had botox for months. * women who are pregnant, breastfeeding, or trying to get pregnant.
prospective study of diabetes-related vascular disease in oklahoma indians

Conditions: Cardiovascular Diseases; Heart Diseases; Diabetes Mellitus, Non-insulin Dependent; Diabetes Mellitus

Summary: to study the relationship between diabetes and various macro- and microvascular complications in oklahoma indians.

background: diabetes is a major health hazard in oklahoma indians. a further important aspect is the apparently high vulnerability of the diabetic oklahoma indians to atherosclerotic disease. in the mid 1980s, this group had the highest prevalence of 0-wave changes on the electrocardiogram and amputation for ischemic gangrene of all 14 international samples in the world health organization multinational study. its cardiovascular mortality rates were 2-3 times those of other national samples. an epidemic of coronary heart disease was attacking this indian population. between 1973 and 1978, 1,085 adult oklahoma indians who were diagnosed with non-insulin dependent diabetes mellitus were recruited for a study on diabetes. the data from the study were used in part for the world health organization multinational study of vascular disease in diabetes. the subjects were given a complete physical examination which included blood pressure, height, weight, electrocardiogram and detailed eye examination. data were also collected on plasma cholesterol, plasma triglyceride, and proteinuria. family histories and body weight were reviewed. the study followed this cohort. design narrative: this longitudinal study followed a previously studied cohort. detailed baseline data collected in 1973-1978 were available. in phase i of the study, the life/death status of all 1,085 subjects was ascertained up to january 1, 1986. death certificates were obtained and cause of death analyzed. for the survivors, a personal interview and physical examination were performed in phase ii. occurrence of specified diabetes-related vascular complications was documented. the detailed follow-up questionnaire included all the data required for the who multinational study of vascular disease in diabetes plus specific information related to this population. analysis was conducted on overall mortality rates, disease-specific mortality rates, and survival time. prevalence and incidence of morbidity from micro- and macrovascular complications were estimated. the extent to which selected risk factors were associated with or could predict the development of vascular diseases was examined. the results of the analyses were compared with those obtained in the who multinational study. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
green subthreshold laser therapy for chronic central serous chorioretinopathy.

Conditions: the Presence of Subretinal Fluid (SRF)

Summary: chronic central serous chorioretinopathy (cscr) is a vision-threatening retinal disorder characterized by persistent subretinal fluid due to choroidal vascular hyperpermeability and retinal pigment epithelium (rpe) dysfunction. this study evaluates the efficacy and safety of green subthreshold laser therapy using norlase µsec technology as a novel, tissue-sparing approach for treating chronic cscr. by targeting rpe repair without inducing visible retinal damage, this technique aims to resolve subretinal fluid, restore retinal architecture, and improve visual function. this is the first study to report clinical outcomes with this specific laser platform in chronic cscr management.


Eligibility criteria:
inclusion criteria: subretinal fluid for more than three months, confirmed by multimodal imaging, diagnosis of chronic csc in at least one eye. exclusion criteria: any evidence of choroidal neovascularization on multimodal imaging, as well as a history of previous photodynamic therapy (pdt) or focal laser treatment for csc, prior diagnosis of ocular hypertension, glaucoma, and optic nerve disorders, presence of active retinal conditions such as vitreomacular traction, epiretinal membrane, diabetic retinopathy, or retinal vein occlusion, lens opacities that could interfere with retinal imaging or compromise visual acuity
pyrocarbon clinical follow-up study

Conditions: Osteoarthritis of the Shoulder; Avascular Necrosis; Traumatic Arthritis

Summary: the objective of this multi-center study is to collect medium and long-term data on the related clinical complications and functional outcomes of the pyrocarbon humeral head to demonstrate safety and performance, in subjects from the pyrocarbon ide study cohort. data collected from this study will support post-market surveillance and mdr requirements as well provide the basis for peer-reviewed publications on mid- and long-term product performance and safety (five to ten years post-op).


Eligibility criteria:
inclusion criteria: * subject in the pyrocarbon ide study and has not had the device explanted. * patient informed, willing, and able to sign an informed consent form approved by irb or ec * willing and able to comply with the requirements of the study protocol exclusion criteria: • subjects who are not able to comply with the study procedures based on the judgment of the assessor will be excluded (e.g. cannot comprehend study questions, inability to keep scheduled assessment times)
effect of aerobic or resistance exercise on the endothelial response in post-acute myocardial infarction patients submitted to angioplasty

Conditions: Cardiac Rehabilitation; Aerobic Exercise; Resistance Exercise

Summary: cardiac rehabilitation, as art and acting science multiprofessional, is based on the training with exercises that provides the post-infarct patients to satisfactorily re-establish the patient's clinical condition and that improve the functional capacity of these individuals. evidence shows that aerobic exercise training provides improvements in the endothelial function of this population. however, we do not yet have strong evidence of other modalities of exercise in these parameters in post-infarction patients treated with angioplasty.


Eligibility criteria:
inclusion criteria: * post-acute myocardial infarction patients * ergometric test 30 days after the infarction * ejection fraction\> 40% (simpson's method) * regular use of optimized drugs exclusion criteria: * unable to perform the randomized exercise
neoadjuvant immunotherapy of operable metastatic melanoma in real life (gcc)

Conditions: Melanoma Metastatic

Summary: this study aims to evaluate efficacy and tolerance of real life neoadjuvant immunotherapy in advanced yet operable melanoma. the complete histological response will be assessed.


Eligibility criteria:
inclusion criteria: * patients with operable metastatic melanoma (stage iii or iv of american joint committee on cancer \[ajcc\] stages classification) treated with neoadjuvant immunotherapy (anti-pd1 or anti-pd1 + anti-ctla-4), even if surgery cancelled due to disease progression or complete response or patient\&#39;s refusal to be operated. * efficacy of the neoadjuvant immunotherapy histologically of radiologically assessed exclusion criteria: * uveal melanoma
treatment of bone cyst with bone marrow mesenchymal cell transplantation

Conditions: Bone Cyst

Summary: there are two types of bone cysts, unicameral and aneurismal. these cysts happen to anyone, but they are most commonly seen in children and young adults while their bones are still growing. living with a bone cyst and determining treatment options depend on the type of cyst. non-surgical treatments for unicameral bone cysts involves repeated x-rays in individuals who do not experience any symptoms. surgical removal of a unicameral bone cyst is needed if it becomes especially painful, or the area of the bone starts to thin out. the investigators aim to assess the clinical efficacy and side effects of mesenchymal stem cells seeded on bone matrix in repairing bone cyst.

bone cysts are benign lesions usually discovered in children from age of 5 to 15 years. treatment options include observation, corticosteroid injection and surgery. sometimes the risk of surgery is comparable to the likelihood of fracture without treatment. in orthopedic surgery, bone chips , various types of ceramics, natural and synthetized bone mineral hydroxyapatite and tricalcium phosphate, as well as numerous polymers and co-polymers of alfa-hydroxy acids are used to perform as an osteoconductive and rarely osteoinductive factor to help bone formation.some evidence demonstrated that bone marrow mesenchymal stem cells deposited on the surface of this constructs enhance its osteogenic differentiation. in this study the investigators seeds cultured bone marrow derived mesenchymal stem cells on bone matrix, to evaluate its therapeutic potential in repairing unicameral or aneurysmal bone cyst.this composite is placed in the bone cyst after its curettage during a surgery.post-operation assessment is done by x-ray examination and mri at 1, 2, 6, and 12 months after treatment.

Eligibility criteria:
inclusion criteria: * bone cyst diagnosed with mri, ct-scan, or x-ray * intact cyst wall with high risk for fracture * cysts with minimum diameter of 6mm * diagnostic test performed on cyst fluid * provided written consent form exclusion criteria: * patients with diagnosis of cancer * patients enrolled in other clinical trial

Keywords: bone cyst bone defect mesenchymal cell
effect of prophylactic clip application for the prevention of postpolypectomy bleeding in pedunculated colonic polyps

Conditions: Bleeding

Summary: although endoscopic colonic polypectomy has been an established procedure for two decades, the risk of bleeding is still higher after resecting of pedunculated polyps, because of the presence of a large artery in the stalk. preventive methods such as endoloop and epinephrine injection have been proposed in the management of postpolypectomy bleeding in large colonic polyps. for prophylactic clip, there was no randomized controlled study assessing the efficacy in the prevention of postpolypectomy bleeding for the large pedunculated polyps. so the investigators designed a randomized controlled trial to confirm the efficacy of application of prophylactic clip in the prevention of postpolypectomy bleeding in large polyps.

patients who had pedunculated colorectal polyps with heads larger than 10 mm and stalks larger than 5 mm in diameter were included. in clip group, hemoclips were applied to the base of the stalk, followed by conventional snare polypectomy. in conventional group, conventional snare polypectomy was done without any preventive management. immediate and delayed bleeding complications were assessed.

Eligibility criteria:
inclusion criteria: * patients with pedunculated colorectal polyps, the heads of which were larger than 10mm and the stalk of which were large than 5 mm in diameter, were included. exclusion criteria: * bleeding tendency, poor preparation, sessile polyp
post thyroidectomy endoscopic laryngeal examination :is it mandatory?

Conditions: Thyroid

Summary: post thyroidectomy laryngeal nerve injuries are frequently encountered specially in total and near total thyroidectomy some unilateral injuries are not clinically evident and asymptomatic. the aim of this study is to compare mandatory versus selective post-thyroidectomy endoscopic examination of larynx to detect laryngeal nerve injuries.

100 patients were randomly divided into two groups, group i for whom mandatory post thyroidectomy endoscopic laryngoscopic examination and the other group of only symptomatic patients selected for direct laryngoscopic examination.

Eligibility criteria:
inclusion criteria: * all post thyroidectomy patients exclusion criteria: -

Keywords: post thyroidectomy laryngeoscopic examination
effect of balneotherapy and physiotherapy treatment in female infertility: a retrospective study

Conditions: Infertility, Female

Summary: the goal of this observational study is to assess the effect of complex balneotherapy and physiotherapy treatment among infertile women treated in the harkany thermal rehabilitation center between july 01, 2007 and december 31, 2021. the main questions it aims to answer are: * to what extent can the complex balneotherapy and physiotherapy treatment be an effective additional therapy in female infertility? * what are the clinical changes behind infertility that can be helped by the complex balneotherapy and physiotherapy treatment? participants will be asked to answer a questionnaire that we have prepared.


Eligibility criteria:
inclusion criteria: * female gender * diagnosed primary or secondary infertility exclusion criteria: * lack of cooperation

Keywords: balneotherapy, physiotherapy, questionnaire, infertility
pediatric open-label extension study

Conditions: Schizophrenia; Autism; Bipolar Depression

Summary: this is an open-label, 104-week, multicenter, extension study designed to evaluate the long-term safety, tolerability and effectiveness of flexibly dosed lurasidone (20, 40, 60 or 80 mg/day) in pediatric subjects who have completed the 6-week treatment period in the preceding studies, d1050301, d1050325, and d1050326


Eligibility criteria:
inclusion criteria: * written informed consent from parent(s) or legal guardian(s) with sufficient intellectual capacity to understand the study and support subjects' participation in the study procedures must be obtained for subjects who are not emancipated. in accordance with institutional review board (irb) or independent ethics committee (iec) requirements, the subject will complete an informed assent when developmentally appropriate, to participate in the study before conduct of any study-specific procedures. * subject has completed study d1050301 (visit 9) or * subject has completed study d1050325 (visit 9) or * subject has completed study d1050326 (visit 8) * subject is judged by the investigator to be appropriate for participation in a 104-week clinical trial in an outpatient setting involving open-label lurasidone treatment, and is able to comply with the protocol. * a reliable informant (eg, parent, legal guardian, or caregiver) must be available to accompany the subject at each visit. for subjects entering from study d1050325, the reliable caregiver must also oversee the administration of the study drug throughout the study * females who participate in this study: * are unable to become pregnant (eg, premenarchal, surgically sterile, etc.) -or- * practices true abstinence (consistent with lifestyle) and must agree to remain abstinent from signing informed consent to at least 7 days after the last dose of study drug has been taken; -or- * are sexually active and willing to use a medically effective method of birth control (eg, male using condom and female using condom, diaphragm, contraceptive sponge, spermicide, contraceptive pill, or intrauterine device) from signing informed consent to at least 7 days after the last dose of study drug has been taken. * males must be willing to remain sexually abstinent (consistent with lifestyle) or use an effective method of birth control (eg, male using condom and female using condom, diaphragm, contraceptive sponge, spermicide, contraceptive pill, or intrauterine device) from signing informed consent to at least 7 days after the last dose of study drug has been taken. exclusion criteria: * subject is considered by the investigator to be at imminent risk of suicide. * exhibits evidence of moderate or severe extrapyramidal symptoms, dystonia, tardive dyskinesia, or any other moderate or severe movement disorder. severity to be determined by the investigator.

Keywords: schizophrenia autism lurasidone latuda
comparing the cognitive effects of two exergame training and traditional training in patients with chronic stroke

Conditions: Stroke

Summary: the objective of this study was to: compare the training and maintenance effects of 3 balance training programs (2 kinds of exergame systems and 1 conventional weight-shifting training program) on cognitive function of subjects with chronic stroke.

the objective of this study was to: compare the training and maintenance effects of 3 balance training programs (2 kinds of exergame systems and 1 conventional weight-shifting training program) on cognitive function of subjects with chronic stroke. we hypothesized that the exergaming program using weight shifting as game controller is better than the weight shifting only program. the investigators further hypothesized that exergames designed for entertainment (such as wii fit) are more beneficial than exergames for rehabilitation purpose (such as tetrax biofeedback) in gain of cognition function for patients with chronic stroke.

Eligibility criteria:
inclusion criteria: * post-stroke duration of at least 6 months * ability to understand verbal instructions and learn * adequate visual acuity (with appropriate correction, if necessary) * ability to walk independently with or without device exclusion criteria: * bilateral hemispheric * cerebellar lesions * aphasia * significant visual field deficits * hemineglect * history of orthopedic * other neurological diseases * medical conditions that would prevent adherence to the exercise protocol

Keywords: stroke cognition exergames weight shifting balance rehabilitation
comparative analysis of short-term therapeutic effects between the π-shaped and overlap methods for esophagogastrostomy in totally laparoscopic total gastrectomy

Conditions: Gastric Cancer

Summary: as of now, although the safety of π-shaped anastomosis and the overlap method has been separately discussed in different contexts, there have been few studies considering a direct comparison of the results of these two methods. this article aims to explore the differences in the short-term therapeutic effects, surgical effectiveness, and safety between laparoscopic total gastrectomy with esophagogastrostomy using the overlap method and the π-shaped method. the goal is to provide new reference points for surgeons in the clinical decision-making process regarding the choice of anastomotic techniques during totally laparoscopic total gastrectomy.


Eligibility criteria:
inclusion criteria:(1) preoperative confirmation through electronic gastroscopy and enhanced ct that the lesion was situated in the fundus, middle and upper third of the gastric body, or the entire stomach; (2) postoperative pathology confirming adenocarcinoma; (3) utilization of either overlap esophagojejunal anastomosis or π-shaped anastomosis in total laparoscopic total gastrectomy. - exclusion criteria:(1) patients with severe preoperative cardiac, hepatic, renal, and pulmonary complications; (2) preoperative neoadjuvant chemotherapy; (3) a history of previous abdominal surgery; (4) patients requiring combined resection due to infiltration of other organs during the operation; (5) patients with incomplete pathological or clinical data. all patients signed informed consent. -
sagit for classification of patients with acromegaly in clinical practice

Conditions: Acromegaly

Summary: the purpose of this pilot study is to test sagit (signs and symptoms - associated comorbidities - gh concentration level - igf-1 - tumour). sagit is a clinician-reported outcomes (clinros) tool developed to describe patients with acromegaly. this study will determine the potential use of a finalised operational version for patient classification in clinical practice and studies. in addition, this study intends to carry out a qualitative evaluation of the acceptability of sagit by the practicing endocrinologist in terms of relevance, ease of use, applicability and usefulness of the tool in practice.


Eligibility criteria:
inclusion criteria: * male or female aged 18 years-old or above * patient with diagnosis of acromegaly with the presence of pituitary adenoma, elevated igf-1 and lack of serum gh suppression after oral glucose tolerance test (ogtt) * controlled/stable, active and treatment naïve patients. * patient with the cognitive and linguistic capacities to understand the information letter of the study * patient who signed informed consent exclusion criteria: * history of non-compliance or inability to reliably receive treatment in the foreseeable future * gaps in treatment of greater than 1 month within the 12 months prior to study entry