Kornimate/medical-research-clean huggingface dataset:
bladder thermal distention for patients with refractory overactive bladder

Conditions: Overactive Bladder

Summary: in this study, the investigators will evaluate the efficacy of bladder thermal distention (btd) in patients with overactive bladder syndrome who failed previous treatment of anticholinergic drugs. the investigators' hypothesis is that it will improve the storage symptoms.

inclusion criteria: 1. patients with overactive bladder syndrome 2. detrusor overactivity proven in urodynamic test exclusion criteria: 1. mixed urinary incontinence 2. active urinary tract infection 3. urethral stricture outcome measures: 1. bladder diaries 2. urgency questionnaire

Eligibility criteria:
inclusion criteria: * patients with overactive bladder syndrome * detrusor overactivity proven in urodynamic test exclusion criteria: * mixed urinary incontinence * active urinary tract infection * urethral stricture

Keywords: overactive bladder bladder distention
the effect of blood pressure on the postoperative cognitive dysfunction

Conditions: Mild Cognitive Impairment

Summary: permanent and temporary cognitive impairment in the perioperative period is of great importance to patients. hypoperfusion due to the intraoperative hypotension is often mentioned as a possible cause of postoperative cognitive dysfunction.

all patients aged above 60 years undergoing planned spinal surgery in the prone position in the duration of 1-3 hours under general anesthesia will be included in the study. in group l (liberal), the value of blood pressure will be corrected with the change of mean arterial pressure (map) ± 25% patient's mean arterial pressure, and group r (restrictive) with the change of map ± 10%. cognitive dysfunction tests will be executed on the day before the surgery, two hours after the surgery and on the third postoperative day. anesthesia will be managed according to the standardised protocol. concentration of desflurane will be adjusted according to entropy values (target 40-50). analgetics will be applied according to surgical pleth index (spi) values. sufentanil will not be applied in the last 15 minutes. extubation will be performed at the operating theatre when meeting all extubation criteria including train of four ratio (tofr) above 92%. neither syntophyllin, nor pharmacological decurarization (syntostigmin) will be applied to the patients.

Eligibility criteria:
inclusion criteria: * gcs 15 * asa risk i - iii * planned spinal surgery in the prone position * duration of the procedure of 1-3 hours exclusion criteria: * hypertension above 180/100 torr preoperatively * blood pressure below 130/80 torr preoperatively

Keywords: postoperative cognitive dysfunction blood pressure anesthesia
comparison of different analgesic nerve blocks in total knee replacement surgery

Conditions: Knee Prosthesis; Pain, Procedural

Summary: the goal of this observational study is to compare the equivalent analgesic efficacy of three regional anesthesia techniques in total knee replacement surgery. the main question it aims to answer is: • non inferiority of each technique in relation to the others participants will receive selective spinal anesthesia and the antalgic nerve block depending on the group they happen to be in. researchers will compare the femoral nerve group+ipack block, the saphenous nerve block+ipack and the subsartorial block groups to see if there is any difference in the pain control in the 24 hours after the surgery.

after adequate venous access is obtained, a light sedation with midazolam 1-2 mg is administered. the patient will be monitored and a selective spinal anesthesia will be performed. after the neuraxial procedure the antalgic block of choice is performed with about 40 ml of long acting local anesthetic. magnesium solfate 1g and dexametasone 4mg are administered after the block. if the patient wishes, a propofol continuos infusion may be administered for sedation during the surgery. before the patient leaves the or, ketorolac 30mg will be administered. pain control after surgery will be achieved with acetaminophen 1g t.i.d., ketorolac 30mg on demand, and morphine solfate if nrs \>5 after ketorolac. every 6 hours the patient will be monitored by the anesthesia team. after 24 hours the antalgic effect of the nerve block is reasonably thought to be over, so the follow up is interrupted.

Eligibility criteria:
inclusion criteria: * age \> 18 y/o * total knee replacement elective surgery * informed consent exclusion criteria: * age \< 18 y/o * surgery with general anesthesia * patients with coagulopaties * patients in chronic opioid therapy * refuse to sign informed consent form * unable to sign informed consent form * know allergies to medication used for analgesia

Keywords: knee post procedural pain regional anesthesia
the effect of placental spontaneous delivery versus manual removal on blood loss during cesarean section. a comparative study

Conditions: Cesarean Section Complications

Summary: the mode of placental delivery may contribute to an increase or decrease in the morbidity associated with cs, and many studies have shown it to be a key role in determining the blood loss during cs. manual removal of the placenta has been implicated in increased blood loss during cs. however, other researchers concluded that it had no detrimental effect on blood loss


Eligibility criteria:
inclusion criteria: * age (18 - 35) years. * primigravida. * unscarred uterus. * singleton pregnancy. * living baby. * body mass index (18 - 30) 37-40 weeks exclusion criteria: * emergency cesarean section due to possibility of maternal distress and blood loss. * cesarean hysterectomy as the placenta will be removed with the uterus. * abnormally adherent placenta: placenta accrete, percreta or placenta previa due to failure of placental separation. * previous cesarean section as the previous scar may affect placental separation. * body mass index less than 18 and more than 30 as extremes of body weight may be associated with increased risks of anemia, bleeding and/or infection. * suspected chorioamnionitis to decrease the risk of disseminated infection. * bleeding disorders to decrease blood loss. * multiple pregnancy due to larger placental volume and blood loss compared with singleton. * any pelvic surgery (appendix - ovarian cyst. - ectopic pregnancy - pelvic abscess) * women with medical illness e.g. pre-eclampsia, anemia (hb less than 11 gm/dl), dm, cardiac, renal ...etc. to decrease the risk of maternal morbidity.
a self-help book for insomnia compared with sleep hygiene advice in patients using sleep medications

Conditions: Hypnotic; Sleep Disorder

Summary: the aim is to assess whether a self-help book for insomnia will improve sleep and reduce hypnotic use among patients on sleep medications.

this study is a randomized controlled trial evaluating the effect of a self-help book for insomnia compared to the effect of sleep hygiene advice in patients using sleep medications. 150 patients will be randomized to receive either the book (75 patients) or the sleep hygiene advice (75 patients). patients will fill questionnaires about sleep and health problems at baseline and after 3-6 months after receiving the written material. the main aims are to assess whether a self-help book is more effective in reducing sleep medication use and sleep problems.

Eligibility criteria:
inclusion criteria: - use of sleep medications on prescription or otc during the last 6 months exclusion criteria: - below 18 years of age
efficacy trial of n-acetylcysteine and sodium bicarbonate for the prevention of contrast-induced acute kidney injury

Conditions: Chronic Kidney Disease

Summary: contrast-induced acute kidney injury(ciaki) was defined as an absolute increase in serum creatinine of more than or equal to 0.3mg/dl (≥ 26.4 μmol/l), a percentage increase in serum creatinine of more than or equal to 50% (1.5-fold from baseline) within 48 hours of intravascular contrast administration in the absence of any alternative causes, or a reduction in urine output documented oliguria of less than 0.5 ml/kg per hour for more than six hours. it is the common cause of new hospital-acquired renal insufficiency. the occurrence of ciaki may be influenced by pre-existing renal insufficiency, diabetic nephropathy, dehydration, congestive heart failure, concurrent administration of nephrotoxic drugs, or the dose and type of contrast media used. previous studies have shown the independent effectiveness of several agents in preventing ciaki. even now, hydration is crucial for preventing ciaki. since ciaki is presumed to be caused by free radical generation, n-acetylcysteine, which is a potent free radical scavenger, is shown to be effective in preventing nephropathy. at the same time, because free radical formation is promoted by an acidic environment, bicarbonate, which alkalinizes renal tubular fluid, has been shown to reduce renal involvement. these days, some studies have shown that hydration with sodium bicarbonate plus n-acetylcysteine was effective and safe in the prevention of ciaki. in these studies, bicarbonate was used for both alkalinizing renal tubular fluid and hydration. however, if we want to do hydration, we can use saline and if we want to alkalinize renal tubular fluid, we might use bicarbonate by bolus injection. actually, bicarbonate for hydration is prepared at sterile preparation room in a hospital, which is very cumbersome procedure and increase in cost. this is one of the reasons that bicarbonate for hydration use does not become common with wide clinical application. in past issues, though it differs depending on the level of the renal dysfunction, the probability of ciaki was 8-33% when hydration was administered, 5-15% when hydration and n-acetylcysteine were administered, and 1.8-1.9% when bicarbonate and n-acetylcysteine were administered. thus, we can hypothesize the combination of n-acetylcysteine and bicarbonate will play a complementary role in preventing contrast-induced nephropathy. this is the rational for this study.


Eligibility criteria:
inclusion criteria: * serum creatinine more or equal than 1.1mg/dl * procedures using contrast media exclusion criteria: * congestive heart failure * serum creatinine less than 1.1mg/dl * allergy to contrast media * preexisting dialysis * emergency catheterization * recent exposure to contrast within 2 days of the study * refuse to entry this study * ptra * dialysis after procedure

Keywords: chronic kidney disease contrast media acute kidney injury n-acetylcysteine bicarbonate
primary surgical prevention of breast cancer-related lymphedema

Conditions: Lymphedema; Mastectomy; Breast Cancer

Summary: lymphedema refers to edema caused by insufficient drainage of interstitial fluid through the lymphatic circulation system. it occurs mainly in the upper and lower extremities and causes chronic inflammation, and finally fibrous adipose tissue is replaced. in this study, the'lympha' (lymphatic microsurgical preventing healing approach) procedure, which connects lymphatic vessels drained from the arm to the side branches of the axillary vein, contributes to the prevention of lymphedema in patients undergoing axillary lymph node dissection for breast cancer. investigator aim to help patients' quality of life by prospectively analyzing the effects and applying them to clinical practice, reducing the incidence of lymphedema.

patients in the lympha group undergo axillary reverse mapping before the start of surgery, and after axillary lymph node resection, lympha procedure is performed in which the lymphatic vessels drained from the arm and the axillary vein are micro-bonded to the side branches.

Eligibility criteria:
inclusion criteria: 1. age over 19 years old 2. patients who are expected to undergo surgery under the diagnosis of breast cancer, and are determined to undergo axillary lymph node dissection before surgery. exclusion criteria: 1. patients with vascular and lymph-related diseases 2. patients with a history of surgical treatment or trauma to both arms and axillary 3. patients with a history of receiving radiation treatment in both arms, chest, and axilla 4. patients with confirmed systemic metastasis with stage 4 breast cancer 5. pregnant and lactating patients
terrorist attack - continuity of care

Conditions: Post-Traumatic Stress Disorder; Major Depressive Episode

Summary: on november 13th 2015, a terrorist attack killed 129 victims in paris. an emergency crisis unit (cump) has been activated in paris in the days following the attack and a subunit was in charge to answer to the phone calls of victims and their relatives. the same emergency crisis unit have been activated for the terrorist attack in london, 2017 june 3, terrorist attack in barcelone 2017 august 17-18, terrorist attack in strasbourg 2018 december 11 the purpose of this observational study is to document the evolution of psychiatric symptoms among subjects who called the cump and to collect information about the type of medical or non-medical care they were seeking for.

the care of the victims of natural disasters or mass disasters such as terrorist attacks is now better structured and organized. the efficacy of debriefing or of defusing has been and is still debated, sometimes bitterly. the aim of the present study is not to demonstrate utility or futility of such approaches, but to i) evaluate their global improvement over the past three years. ii) to list the type of support that the victims were seeking in their attempt to get rid of the symptoms which appeared after the terrorist attack of november 2015 in paris. iii) to collect their opinions about the way the cump (emergency medico-psychological unit of paris, france) managed the support to the victims. participating subjects registered on the occasion of their first contact with the cump 75 by phone during the week following the attack

Eligibility criteria:
inclusion criteria: - all subjects who called the cump of paris between november 13th, 2015 and january 31st, 2016; london 11th,2017 ; barcelone 17-18th, 2017 ; strasbourg 11th, 2018 and completed the questionnaire. exclusion criteria: - subjects who did not consent to their participation to the study.

Keywords: terrorist attack post-traumatic stress disorder depression psychotherapy mental health victimology mourning
comparative study in the efficacy of topical besifloxocin with erythromycin for the management of acute blepharitis

Conditions: Blepharitis

Summary: this study looks at the improvements in signs and symptoms in patients with inflammation of the lids, blepharitis, using two different fda approved topical antibiotic agents, besifloxocin and erythromycin. it also evaluates the bacterial cultures in these patients for microbiologic evidence of improvement.

this is a pilot project involving thirty patients with a specific form of inflammtion of the lids called anterior blepharitis. the patients are graded for their signs a symptoms and then randomized to receive either topical besifloxocin or erythromycin in addition to standard lid hygiene measures. all patients have cultures of their eyelids performed prior to initiating therapy and are followed for four weeks. the antibiotics are used for two weeks following which repeat cultures of the lids are obtained. the patients are followed for one additional week to ensure that there is no recurrence of their symptoms once the antibiotics are discontinued. only adult patients (age 18-100)and women who are not of child bearing potential are included in this study. then patients have to have symptoms and signs of the disease, blepharitis. patient who are on unstable antibiotic or steroid regimens and those who cannot discontinue contact lens use are not included in this study.

Eligibility criteria:
inclusion criteria:acute blepharitis, age 18-100, signs and symptoms of blepharitis - exclusion criteria: women of child bearing potential, eye surgery within three months of study, contact lens wear, use of topical or antibacterial agents in past two weeks, use of topical or oral steroids in past two weeks unless stable dosage -

Keywords: blepharitis topical erythromycin topical besifloxocin
safety and efficacy of didala monotherapy in patients with type 2 diabetes compared with metformin.

Conditions: Type 2 Diabetes

Summary: this is an open-label, two-group parallel study, comparing before and after treatment within the same group and between the two groups. this study is designed to collect data on the safety and efficacy of a marketed pharmaceutical product (didala) compared with metformin. the efficacy data of didala will be directly compared with metformin 1000mg/day monotherapy in this study.


Eligibility criteria:
inclusion criteria: * 18 years or older at the time of enrollment in the study. * diagnosed with type 2 diabetes according to the guidelines for the diagnosis of type 2 diabetes of the ministry of health (2011). * fasting blood glucose ≤ 10.0 mmol/l. * no previous treatment with metformin or other antidiabetic drugs. * ability and willingness to provide written informed consent and comply with the protocol's requirements. * subject who, in the judgment of the investigator, is likely to be compliant or cooperative during the study. exclusion criteria: * the patient has been diagnosed with diabetes and has been previously treated with metformin or other antidiabetic agents. * patients with indications for insulin therapy or combination therapy of two or more drugs according to the guidelines for diagnosis and treatment of type 2 diabetes of the ministry of health. * pregnancy or lactation. * patients with contraindications to metformin include severe liver and/or kidney disease, congestive heart failure, cardiovascular collapse, acute myocardial infarction, severe infection, and sepsis. * patients with conditions and circumstances that, in the investigator's opinion, are difficult to ensure adherence to study protocol.
comparison of nikkomycin z bioavailability under fed and fasting conditions

Conditions: Healthy

Summary: the primary purpose of this study is to evaluate if eating a high fat meal versus not eating any food affects how the study drug (nikkomycin z) is absorbed into the body. the second purpose is to gain further information about the safety of nikkomycin z in healthy adults.

to compare the single-dose bioavailability of nikkomycin z 500 mg (two 250 mg capsules) under fed and fasting conditions.

Eligibility criteria:
inclusion criteria: * be at least 18 years of age and not over 40 years of age * be male, or female (non childbearing potential or using adequate contraception) * have a body mass index between 18 and 29 kg/m2 * able to understand the study and give written informed consent * be determined healthy based on a medical and laboratory evaluation exclusion criteria: * patients under the age of 18 years or over 40 years of age * current smoker or history of smoking within 3 months of participation * inability to comprehend study and provide written informed consent * inability to comply with the study requirements * history of or current evidence of major organ disease * renal disease - serum creatinine \> 1.5 mg/dl, significant hematuria or proteinuria, known structural abnormality or chronic kidney disease * hepatic disease - active viral hepatitis, history of hepatitis b or hepatitis c, bilirubin \> 2.0, alt or ast above normal upper limit for laboratory, alcoholic liver disease, other chronic liver disease * cns disease or cognitive dysfunction - any past history of epilepsy, cns infections, stroke, cns bleed, severe headaches, major psychiatric illness, or current mental status changes * lung disease - history of severe asthma, copd, pulmonary tuberculosis, or other major lung disease * cardiac disease - history or current evidence of ischemic coronary artery disease, myocardial infarction, heart failure, or significant arrhythmia * gastrointestinal disease - presence of inflammatory bowel disease, difficulty swallowing, or any gastrointestinal probably that would limit taking oral medications or that may compromise absorption of oral medications * cancer - history of hematologic malignancy or solid tumor excluding basal cell carcinoma limited to the skin within the past 5 years * history of autoimmune or inflammatory disease such as rheumatoid arthritis and lupus * immunocompromised state - solid organ transplant, cancer chemotherapy, stem cell transplant with graft versus host disease, immunosuppressive therapy, or hiv infection * recent weight loss of greater than 10% * any other history or evidence of disease that in the opinion of the physician would increase the risk for the subject for clinical trial participation * regular use of prescription medications, over-the-counter medications, or dietary/herbal supplements within 14 days of day 1. occasional use of acetaminophen or over-the-counter nsaid within the 14 day window may be allowed at the p.i. discretion * subjects who received another investigational drug within 30 days of enrollment

Keywords: bioavailability fed fasting
temporomandibular joint problems and core stabilization

Conditions: Temporomandibular Joint Disorders; Core Stability

Summary: this study aimed to investigate the relationship between temporomandibular joint problems, head posture, tongue strength, and endurance with core stabilization.

this cross-sectional study was conducted on university students aged 18-31 between september 2022 and february 2023. in the evaluation of the students were used that the fonseca's anamnestic questionnaire for temporomandibular joint dysfunction, research diagnostic criteria for temporomandibular disorders examination form for maximum pain-free mouth opening, presence of sound in temporomandibular joint movements, and palpation parameters of temporomandibular joint and surrounding muscles, craniovertebral angle for forward head posture, and iowa oral performance instrument for tongue strength and endurance. in addition, the trunk flexor endurance test and biering sorenson test were used for static endurance of the core muscles, and sit-ups test and modified push-ups test were used for dynamic endurance of the core muscles.

Eligibility criteria:
inclusion criteria: * university students aged 18 and 31 who agreed to participate in the study * signed the informed consent form were included. exclusion criteria: * having a non-reducible disc problem, * having surgery related to spine, abdomen and/or tmj problem, * history of trauma, cancer, * presence of neurological problems, congenital anomaly, musculoskeletal problems, systemic disease, facial paralysis, * receiving any treatment related to the spine and tmj in less than six months.

Keywords: temporomandibular disorders core stability head posture tongue strength