Kornimate/medical-research-clean huggingface dataset:
early prescription of radiography using the ottawa ankle rules by a nurse in the management of isolated ankle trauma

Conditions: Ankle Injuries; Nurse's Role; Emergencies

Summary: the study will be conducted in 2 phases (a and b) using two different groups of patients in order to prove that an early prescription of radiography using the ottawa ankle rules by a nurse practitioner could shorten length of stay of a patient suffering from ankle trauma at the hospital center of saint-brieuc.

ankle sprain is an injury very frequently encountered during consultation in hospitals emergency departments. its mechanism may at times leads to fracture. the ottawa ankle rules (oar) provide guidelines to clinicians concerning the need to perform radiographic test to verify whether patients with ankle injuries are suffering from fracture. if all clinical and anamnestic criteria are negative in accordance with the oar, the probability of a fracture being present is about 0% (ic 95%). oar are validated for adults. actually, a meta-analysis has suggested that it may be beneficial to introduce a nurse-initiated radiographic test protocol as a standard practice in emergency departments. however this early prescription is not a standard of care in most of emergency departments in france. the implementation of oar decreases irradiation levels of patients and reduces medical expenses. in addition, it allows to reduce patient's duration of stay in already encumbered emergency departments, thus reducing also overcrowding, which is known to be a major factor of non quality of care in such departments. the study will be conducted in 2 phases of 4 weeks each : * the first one (phase a) will occur in the emergency department with the application of oar only by the physicians (without changing the standard of care) * the second one (phase b) will occur after the phase a, and nurses will apply oar before physicians, according to the protocol.

Eligibility criteria:
inclusion criteria: * with closed ankle injury less than 10 days old * affiliation to the national health insurance * written informed consent must be obtained exclusion criteria: * trauma dating more than 10 days * patient not affiliated to the national health insurance * x-ray performed before patient admission * other trauma than an isolated trauma of the ankle * injury other than ankle injury : calcaneus, toes, and achilles' tendon * paraplegic or quadriplegic patient * previous admission to the emergency department for the same traumatic event * patient already included in the pariao study * isolated skin injury / isolated superficial injury * ankle fracture or obvious deformation * neuro-vascular deficit * mental disorder * adults legally protected (under judicial protection, guardianship, or supervision), persons deprived of their liberty * excessive alcoholization or intoxication by other psychoactive substances (physician's decision) * uncooperative patient * pregnancy in progress

Keywords: overcrowding x rays emergency department ottawa ankle rules nurse practitioner
can thyroidectomy be considered safe in obese patients?

Conditions: Obesity; Thyroid; Surgery--Complications

Summary: obesity is a growing public health concern in most western countries. more and more patients with high body mass index (bmi) are undergoing surgical procedures of all kinds and, in this context, obese patients are undergoing thyroid surgery more than ever before. this study showed that obesity, in the field of thyroid surgery, is not associated with any increase of postoperative complications. thus, it is possible to conclude that thyroidectomy can be performed safely in obese patients.

background: obesity is a growing public health concern in most western countries. more and more patients with high body mass index (bmi) are undergoing surgical procedures of all kinds and, in this context, obese patients are undergoing thyroid surgery more than ever before. the aim of the present study was to evaluate whether thyroidectomy can be considered safe in obese patients. methods: patients undergoing thyroidectomy in our unit between january 2014 and december 2018 were retrospectively analysed. patients were divided into 2 groups: those with bmi \< 30 kg/m2 were included in group a, while those with bmi ≥ 30 kg/m2 in group b.

Eligibility criteria:
inclusion criteria: * patients submitted to thyroidectomy in our unit exclusion criteria: -
refractive disorders and seric vitamin d level in children with disabilities

Conditions: Child, Only

Summary: the investigator want to determine the refractive status of 80 children with disabilities and of 81 healthy children from a witness group. the vitamin d level of the children will be dosed for making different correlations with visual acuity status.

refraction measurement will be done by the investigator in all 161 children. visual acuity is checked, initial and after correction with proper correction. vitamin d level is dosed from all the children in order to make correlations with the visual acuity, refractive status and risk for visual impairment.

Eligibility criteria:
inclusion criteria: * children with disabilities and healthy children exclusion criteria: * children diagnosed with another chronic diseases

Keywords: disability, healthy
a study to evaluate the real-world usage and effectiveness of elocta and alprolix in patients with haemophilia a or b

Conditions: Haemophilia A; Haemophilia B

Summary: elocta (rfviiifc) and alprolix (rfixfc) are recombinant extended half-life coagulation factor products. the purpose of this non-interventional study is to describe the real-world usage and effectiveness of elocta and alprolix in the prophylactic treatment of haemophilia a and b.


Eligibility criteria:
inclusion criteria: * have a diagnosis of haemophilia a or b and previously treated with factor product * have started prophylactic elocta/alprolix treatment prior to enrollment visit, or at enrollment prescribed prophylactic treatment with elocta or alprolix regardless of participation in the study * signed and dated informed consent provided by the patient, or the patient's legally acceptable representative for patients under the legal age, before any study-related activities are undertaken. assent should be obtained from paediatric patients according to local regulations. exclusion criteria: * participation in an investigational medicinal product trial, from four weeks prior to first injection with elocta or alprolix to enrollment visit.

Keywords: blood coagulation disorder hematologic diseases coagulation protein disorder hemorrhagic disorder genetic diseases, inborn
the effects of foods on cell damage study

Conditions: DNA Damage; Inflammation

Summary: studies have shown that certain compounds inside vegetables can reduce the risk of cancer. carrots in particular have an association with reduced incidence of colorectal, bladder and breast cancer. compounds in carrots, called polyacetylenes, have been studied in isolated cells that have shown a reduction in cancer cells as well as inflammatory markers which have been associated with an increased risk of cancer. these polyacetylenes have not been well studied in the human body and it is unclear whether they are able to affect the biomarkers of health (disease) including dna damage and inflammatory markers. the aim of this research project is to determine whether eating a portion of white carrots every day for 6 weeks can lead to a reduction in dna damage and inflammatory markers compared to a control period of 6 weeks consuming a polyacetylene-free diet and a control food of a high fibre oat biscuit.


Eligibility criteria:
inclusion criteria: * non -smokers * bmi between 18.5 and 30 exclusion criteria: * smoking * taking anti-inflammatories * taking aspirin or aspirin-like drugs * antibiotic use in the last 3 months * metabolic conditions or conditions affecting the metabolism or digestion

Keywords: cancer inflammation dietary intervention trial
immunogenicity of quadrivalent meningococcal conjugate vaccine in frequent platelets donors

Conditions: Preventive Immunization; Meningitis

Summary: in this study, the investigators will evaluate the immunogenicity of a quadrivalent conjugate meningococcal vaccine in healthy, plateletpheresis donors.

this will be an open-label prospective vaccine response study evaluating one dose of menacwy-d in plateletpheresis donors at the brigham and women's hospital (bwh). potential participants will be divided into three groups according to the number of plateletpheresis within 365 days of enrollment (including the day of enrollment): 1-2 sessions group (considered as the control group), 3-19 sessions group, 20-24 sessions group and randomly sampled from in allocation proportions of 0.45, 0.10, and 0.45, respectively; justification for this approach is provided in the statistical analysis section. menacwy-d vaccine will be administered to each patient. pre- and post-vaccination blood will be collected to assess immunogenicity, likely using serum bactericidal antibody (sba) against neisseria meningitidis for each serogroup. immunogenicity will be primarily evaluated by seroresponse such as a fourfold increase of sba titers between pre- and post-vaccination.

Eligibility criteria:
inclusion criteria: * male or female aged 18 years old or older * meet the standard requirements to donate platelets * have had at least one plateletpheresis in the prior 365 days (including the day of enrollment) exclusion criteria: * participants who donated platelets in any other medical center in the previous 365 days * severe allergic reaction to a previous meningococcal vaccine or to any component of menacyw-d * history of guillain-barré syndrome
indocyanine green for detection of sentinel lymph nodes in comparison to icg plus technetium in the evaluation of vulvar squamous cell carcinoma

Conditions: Vulvar Cancer

Summary: the aim of this study is to confirm prospectively if the use of near infrared-indocyanine green (nir-icg) alone offers similar accuracy and sensitivity to the gold standard dual technique for sentinel lymph node detection in early stage vulvar cancer.


Eligibility criteria:
inclusion criteria: adult women (18 years of age) with figo stage ib (\> 1 mm depth of invasion) and small stage ii (4 cm) vulvar squamous cell carcinoma or cutaneous melanoma who are candidates for the sentinel lymph node technique will be included (negative clinical groin examination and/or imaging and primary unifocal vulvar tumor size of \< 4 cm). exclusion criteria: women with a prior history of pelvic, vulvovaginal or inguinal radiation, with allergy or hypersensitivity to technetium or icg, or bartholin gland cancer will be excluded.
preoperative intravenous ferric carboxymaltose and placebo in the treatment of patients undergoing cardiac surgery

Conditions: Coronary Artery Disease; Postoperative Complications; Aortic Valve Stenosis; Mitral Valve Disease; Aortic Aneurysm, Thoracic

Summary: this study evaluates the efficacy and safety of single dose preoperative ferric carboxymaltose in the prevention of postoperative infections and blood transfusions in patients scheduled for cardiac surgery. half of the patients will receive ferric carboxymaltose and half of the patients physiological saline solution as placebo.


Eligibility criteria:
inclusion criteria: 1. patients presenting with cardiac disease requiring surgical operation 2. open heart surgery is considered the best appropriate treatment strategy according to the current guidelines. * significant three vessel disease * left main disease ± single, two or three vessel disease * two-vessel disease with proximal lad stenosis * coronary artery disease requiring revascularization not amenable to percutaneous coronary intervention * aortic valve disease requiring aortic valve surgery * mitral valve disease requiring surgical mitral surgery * combined surgery for revascularization and valve disease * surgery of ascending aorta 3. have provided signed written informed consent exclusion criteria: 1. age \< 35 years 2. patients requiring , emergency or salvage cardiac surgical operation 3. participation in another clinical study or treatment with another investigational product 30 days prior to randomization 4. moribund patient not expected to survive surgery 12 months after surgery 5. active malignant disease with a short life expectancy, not eligible for surgery 6. hemoglobin levels \> 155 g/dl for women and \>167 g/dl for men (upper reference limits for tykslab) 7. ferritin levels \>150 ug/l for women and \>400 ug/l for men. 8. renal dialysis therapy for chronic renal failure or severe preoperative renal impairment (egfr\<30ml/min). 9. study treatment can't be infused during the required time window: minimum 48 hours and maximum 21 days before the operation. 10. ongoing oral or parenteral iron medication at the time of randomization 11. iron or haemoglobin metabolism or synthesis disorders 12. primary or secondary hemochromatosis (in males and postmenopausal females, a serum ferritin value of over 300 ng/ml (670 pmol/l); and in premenopausal females, a serum ferritin value of over 150\[17\] or 200\[18\] ng/ml (330 or 440 pmol/l) indicates iron overload). 13. porphyria cutanea tarda. 14. liver failure (child-pugh class b or c). 15. pregnancy. 16. body weight less than 50kg. 17. ongoing antibiotic treatment other than prophylactic urine tract infection antibiotics.

Keywords: cabg cardiac surgery blood transfusion intravenous iron postoperative infection
study of myocardial deformation parameters in patients with hypertrophic cardiomyopathy

Conditions: Hypertrophic Cardiomyopathy

Summary: the purpose of the study is to investigate the potential correlations of global longitudinal strain and peak left atrial strain, measured by speckle tracking echocardiography with the severity of hypertrophic cardiomyopathy and the risk for arrhythmias. specifically the investigational questions are: 1. is there a correlation between myocardial deformation parameters of the left heart chambers with other important ultrasound parameters (eg maximal wall thickness, presence of subaortic obstruction, etc.) in patients with hypertrophic cardiomyopathy? 2. is there a correlation between myocardial deformation parameters of the left heart chambers and the symptomatology or functional capacity of patients with hypertrophic cardiomyopathy? 3. is there a correlation between the myocardial deformation parameters of the left heart chambers and the exercise capacity, as evidenced by the cardiopulmonary exercise test, in patients with hypertrophic cardiomyopathy? 4. is there a correlation between myocardial deformation parameters of the left heart chambers with the risk of ventricular or supraventricular arrhythmias in patients with hypertrophic cardiomyopathy? 5. is there a correlation between myocardial deformation parameters of the left heart chambers and risk factors for sudden death?

myocardial deformation parameters of the left heart chambers are of particular clinical importance because of their possible association with the severity of hcm and the presence of arrhythmias. however,current literature appears conflicting. this is a prospective cohort study aiming to examine the echocardiographic parameters of myocardial deformation, estimated by the "speckle tracking" method, and their correlation with clinical presentation and symptomatology, other imaging parameters, exercise capacity, arrhythmias (ventricular or supraventricular) and risk factors for sudden death in patients with hypertrophic cardiomyopathy. although, similar efforts have been made in international literature, they are scarce and their results contradictory. the present study is the first to be performed in a greek population, a fact that is particularly important given the genetic heterogeneity of the disease.

Eligibility criteria:
inclusion criteria: -patients with diagnosed hypertrophic cardiomyopathy exclusion criteria: * concomitant severe valvular heart disease * prior myocardial infarction * history of atrial fibrillation
human and microbial determinants of the onset of ibd flares

Conditions: IBD (Inflammatory Bowel Disease)

Summary: this study will collect longitudinal biological samples and survey data to identify the triggers of ibd flares.

this is a longitudinal observational study whose goals are to identify: microbial and human molecular triggers of ibd relapses, microbial and human molecular pathways strongly associated with flares that could be targeted with nutrition with a therapeutic potential, biomarkers of ibd for dx purposes, identify microbial functions associated with release of bh4.

Eligibility criteria:
inclusion criteria: * patient at universidade federal de santa catarina (ufsc) hospital, under care of dr. vivian menegassi exclusion criteria: * cancer diagnosis/treatment * under 18 years old

Keywords: observational ibd microbiome
retrospective multicentre observational study on the incidence of hyperoxia in non-intubated patients in intensive care in belgium study oxsizgen

Conditions: Hyperoxia

Summary: oxygen is the most widely prescribed therapy in the icu (intensive care unit) and can save lives in critical patients. while the deleterious effects of hypoxia are apparent and must be actively avoided, hyperoxia also has adverse effects. these include systemic, coronary and cerebral vasoconstriction; decreased coronary blood flow; pulmonary atelectasis and increased free radicals. despite these deleterious effects, hyperoxia is common and frequent in the icu (from 22% to 74%). a recent meta-analysis published in "the lancet" with more than 16,000 patients demonstrated an association between liberal oxygen therapy and mortality in critical patients. other meta-analyses confirm its results with high quality data according to the authors. a randomized controlled trial published in "the new england journal of medicine" comparing liberal versus conservative oxygen therapy showed no difference in mechanical ventilation days and mortality (the icu-rox, 2019). however, the difference in pao2 between the two groups was very small and the pao2 in the liberal group did not exceed 100 mmhg. in any case, conservative oxygen therapy is safe for critical patients. the recommendations therefore recommend an oxygen saturation between 94-97% in critical patients and 88-92% in patients with copd (chronic obstructive pulmonary disease) . however, to our knowledge, no study has described the incidence of hyperoxia in non-intubated patients in the intensive care unit.


Eligibility criteria:
inclusion criteria: * patient having oxygen * not to be ventilated * being over 18 years old exclusion criteria: * sickle cell disease patient * patient with pneumo/hemothorax * pregnant women, prisoners, denial of informed consent * patients who are related to an investigator * patients undergoing hyperbaric chamber therapy * patients with co * patients on ecmo * patients with paracoate poisoning... * patients included in other interventional studies
a retrospective analysis: whether five factors affect pfs in patients with locally advanced cervical cancer

Conditions: Locally Advanced Cervical Cancer; Radiotherapy

Summary: in previous studies, the investigators found that five factors were effective in predicting the probability of locally advanced cervical cancer with para-aortic lymph node metastasis.a retrospective study was conducted to explore the influence of 5 factors on pfs in patients with locally advanced cervical cancer receiving radiotherapy and chemotherapy.

in previous studies, the investigators found that five factors were effective in predicting the probability of locally advanced cervical cancer with para-aortic lymph node metastasis.5 factors included positive iliac lymph nodes, histological type, tumor size, positive pelvic lymph nodes on both sides, and maximum lymph node diameter greater than 1cm. different factors give different scores.if the score is higher than 3, the probability of retroperitoneal lymph node metastasis in patients with locally advanced cervical cancer is significantly increased, and the prognosis of patients is affected. patients with locally advanced cervix receiving radical radiotherapy were scored based on 5 factors.patients with scores greater than or equal to 3 points were compared with patients with scores less than 3 points.

Eligibility criteria:
locally advanced cervical cancer patients receiving radiotherapy
reaching out to the undiagnosed people infected with blood borne viral infections

Conditions: Hepatitis B; Hepatitis c; Human Immunodeficiency Virus

Summary: title reaching out to the undiagnosed people infected with blood-borne viral infections (runtobbv) objectives 1. to study the efficacy of an outreach methodology to increase the uptake for screening, linkage to care and treatment in (active or former) people who use drugs (pwud) trial design prospective multicenter interventional cohort design number of subjects 336 inclusions (with prevalence of hcv ab: 30%) * 168 antwerp * 168 limburg selection criteria inclusion criteria: * 18 years of age * history of/ or active drug use * written informed consent obtained exclusion criteria * currently enrolled in centralized ost program of free clinic or cad limburg endpoints the following endpoints will be compared between the centers in limburg and antwerp: (main outcome in bold) main objectives: * prevalence of blood-borne viral infections in belgian (former or active) pwud: * hcv infection (number of hcv ab+ / number of screened pwud) * hbv infection (number of hbsag+/number of screened pwud) * hiv infection (number of hiv ab+/number of screened pwud) * analysis of linkage to care to hepatologist/ infectiologist (number of patients who adhered to their consultation/number of referred patients) secondary objectives: * analysis of risk behavior/sociodemographics linked to presence of bbv infections * analysis of uptake of anti(retro)viral treatment (number of patients started on treatment/number of patients needing treatment) * analysis of treatment adherence (adherence to treatment consultations/total planned consultations) * analysis of treatment outcome (total number of cured or virally suppressed patients/total number of treated patients)


Eligibility criteria:
inclusion criteria: * 18 years of age * history of drug use * active drug use * written informed consent obtained exclusion criteria: * currently enrolled in ost program of free clinic or cad limburg (centralized ost provision)