Kornimate/medical-research-clean huggingface dataset:
playing-related factors and occupational balance

Conditions: Occupational Balance; Posture

Summary: as the violin is the riskiest string instrument played by turkish musicians, violinists were chosen for the sample in this study. the aim of this study was to investigate the relationship between posture, pain, functionality and occupational balance in violinists. the hypothesis was that good playing posture, lack of pain, and functionality affect occupational balance positively.

occupational balance is the participation in and satisfaction derived from different elements of daily life, including work. playing performance affects occupational balance of musicians so that complaints arising from the playing of their instruments may negatively affect occupational balance. forty-five violinists at six different symphony orchestras and conservatories in istanbul were included. the personal information form, the edinburgh handedness inventory, the wong-baker faces pain rating scale, the disability of arm, shoulder and hand - sports/musicians (dash-sm), the rapid upper limb assessment, and the 11-item revised version of the occupational balance questionnaire (obq11 - t) were used. spearman correlation analysis was performed to examine the relationship between the variables.

Eligibility criteria:
inclusion criteria: * to play the violin in a conservatory or orchestra, * to be at least 18 years old, * to volunteer to participate in this study. exclusion criteria: * those who played any other instrument professionally.

Keywords: functionality playing-related pain posture occupational balance violinists
impact of daylight on patients with acute myocardial infarction

Conditions: Coronary Arteriosclerosis; Myocardial Infarction

Summary: the study tests if intense light could be a potential therapy in humans after myocardial infarction by inducing per2.

damage to the heart caused by a myocardial infarction (heart attack) occurs most often during the early morning hours (6am). thus, the involvement of the circadian system (circa= approximately day) has been suggested. the circadian system in humans or animals is based on the rotation of the earth with day and night phases. when humans (or animals) wake up light shines in their eyes and the body receives a signal that the day starts. for the human body it means that certain proteins (named clock, period etc) are produced. the protein that determines the length of a day (awake and sleep period) is called period 2 (per2). recent data indicated that the per2 protein in hearts from mice is induced after daylight exposure (daylight with an intensity comparable to a bright day at the beach was used, approx. 10 000 lux). this more per2 was able to protect the heart from being damaged by no blood going to the heart (protection from a heart attack). this protection was based on a more efficient use of sugars (carbohydrates). thereby the heart needs less oxygen. current data indicate that human per2 is also induced by light exposure and can be detected in human plasma samples. in this study per2 transcript and protein levels will be analyzed in patients that just experienced a heart attack with and without intense light (daylight) therapy utilizing blood samples (erythrocytes and leukocytes).

Eligibility criteria:
inclusion criteria: * patients with an acute myocardial infarction * healthy volunteers * must speak and understand english exclusion criteria: * patients with an acute myocardial infarction but are too sick, e.g. severe symptoms, chest pain, generally unstable, etc.
comparison of two methods of patellar resurfacing in total knee arthroplasty

Conditions: Osteoarthritis

Summary: the aim of this prospective, randomized study was to compare the clinical and radiological results of "free-hand" technique and "resection guide" technique for preparing patella during total knee arthroplasty.

with improved surgical techniques and implant designs, patella resurfacing has been favored by increasing surgeons. when performing the resection, several principles such as restoring the original patellar thickness, avoiding over or under resection must be complied in order to achieve satisfactory outcomes.this study was conducted to compared the outcomes of two commonly adopted methods for performing patellar resection in total knee arthroplasty. one hundred patients with osteoarthritis were recruited in the clinical trial using nexgen legacy posterior stabilized-flex prosthesis. patients were randomized to receive "free-hand" technique and "resection guide" technique when performing patellar resection in total knee arthroplasty. patients were evaluated preoperatively and at follow-up visits conducted at twelve months, at twenty-four months. clinical outcome was assessed and compared with use of the visual analogue pain scale (vas), range of motion, knee society score (kss), western ontario and mcmaster universities osteoarthritis index (womac), and the short form-36 (sf-36). patellar alignment was assessed before surgery and at each follow-up by measuring the patellar tilt (pt) and lateral patellar displacement (pd). prosthetic position and leg alignment were also compared between the two groups.

Eligibility criteria:
inclusion criteria: diagnosis of primary osteoarthritis of the knee, with ahlbäck grade of ≥2 (symptoms persisting after conservative treatment for at least 3 months) knees with \<20° varus or \<15° valgus deformity patellar thickness is more than 21mm exclusion criteria: restricted motion (flexion contracture of \>25°) patella alta (insall-salvati ratio of \<0.6) history of previous knee surgery

Keywords: patella total knee arthroplasty resection
autologous adipose-derived stromal cells delivered into the corpus cavernous in patients with erectile dysfunction

Conditions: Erectile Dysfunction

Summary: this will be an open-label, non-randomized, multi-center, patient sponsored study of adipose-derived stromal vascular fraction cells (ad-svf) implantation delivered into the corpus cavernous in patients with erectile dysfunction. the intent of this clinical study is to answer the questions: 1) is the proposed treatment safe and 2) is treatment effective in improving the disease pathology of patients with diagnosed erectile dysfunction.

ad-svf will be collected from the patient's adipose-derived tissue (body fat). using local anesthesia, liposuction will be performed to collect the adipose tissue specimen. the adipose tissue is then transferred to the laboratory for separation of the adipose tissue derived stem cells. in addition, peripheral blood will be collected for isolation of platelet rich plasma, which are then combined with the asc's for direct injection to the corpus cavernosum (penis).

Eligibility criteria:
inclusion criteria * males age 18 and 80 years. * penile arterial insufficiency and or venous leakage (doppler) at the time o inclusion: psv \ 25 cm/sec, edv\>5cm/sec, ri\<0,75. * up to date on all age and gender appropriate cancer screening per american cancer society exclusion criteria * severe co-morbidities like cardiac insufficiency, congestive cardiac failure (nyha ≥ iii), malignancy, infection, sepsis and bed sores. * life expectancy \< 6 months due to concomitant illnesses. * exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study. * active infectious disease. patients known to have tested positive for hiv, htlv, hbv, hcv, cmv (igm \> igg) and/or syphilis will be evaluated by an expert as to patient eligibility based on the patient's infectious status * any illness which, in the investigator's judgment, will interfere with the patient's ability to comply with the protocol, compromise patient safety, or \\ interfere with the interpretation of the study results * patients on chronic immunosuppressive transplant therapy * systolic blood pressure (supine) ≤90 mmhg or greater than 200mmhg * resting heart rate \> 100 bpm; * active clinical infection within one week of enrollment. * known drug or alcohol dependence or any other factors which will interfere with the study conduct or interpretation of the results or who in the opinion of the investigator are not suitable to participate. * history of cancer (other than non-melanoma skin cancer or in-situ cervical cancer) in the last five years. * unwilling and/or not able to give written informed consent.

Keywords: stem cell erectile dysfunction
efficacy of humira in subjects with active rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of the study is to assess the efficacy of adalimumab in subjects with rheumatoid arthritis focusing on subject-reported outcomes and early response to treatment


Eligibility criteria:
inclusion criteria: * subject was age 18 or older and in good health (investigator discretion) with a recent stable medical history. * subject, based on assessment of investigator, meets the definition of active ra exclusion criteria: * subject considered by the investigator, for any reason, to be an unsuitable candidate for the study * female subject who is pregnant or breast-feeding or considering becoming pregnant

Keywords: adalimumab rheumatoid arthritis
immune response to the covid-19 vaccine

Conditions: Covid19; Cancer; Malignancy; Vaccine Response Impaired

Summary: explore the effects on immune response to include a potential third vaccine for the cancer cohort.

in recent work performed by the university of arizona cancer center team, 59 patients with a known diagnosis of a solid tumor malignancy on active immunosuppressive cancer therapy were enrolled through the university of arizona cancer center during their routine care. these subjects had a decreased response with the vaccine when compared to the health cohort. the investigators are amending this study to explore the effects on immune response to include a potential third vaccine for the cancer cohort. this will increase the visits required to approximately two more visits. it will require two additional blood samples, one 48 hours prior to third vaccine and the second, 5-11 days after the third vaccine. the following protocol will be for the subjects that decide to continue onto a third vaccination.

Eligibility criteria:
inclusion criteria: 1. patients must have active solid tumor malignancy diagnosis 2. on active chemotherapy 3. received two prior sars-cov2 pfizer vaccines 4. age ≥ 18 years 5. ability to understand and the willingness to sign a written informed consent 6. agree to comply with study procedures 7. subjects previously enrolled under the main study exclusion criteria: 1. history of hiv or organ/bone marrow transplant 2. actively receiving immunotherapy 3. on active, chronic immunosuppression (\>10 mg daily dose of prednisone equivalent) 4. currently incarcerated or residence of another state 5. speaks a language other than english.

Keywords: covid-19 vaccine pfizer covid-a9 vaccine covid vaccine study
comparing the effectiveness of written vs verbal advice for first degree relatives of colorectal cancer patients

Conditions: Colorectal Cancer

Summary: crc patients were enrolled and asked about their fdr contacts these fdrs were telephoned and enrolled and randomized to receive either written advice and verbal advice about their cancer risk and screening methods. these fdrs were telephoned after 2 weeks to evaluate their knowledge about crc risk and method of screening to see which method of giving advice was better.

1. colorectal cancer patients in a tertiary referral hospital who had first degree relatives in the screening range were enrolled into the study. 2. crc patients and their fdrs were randomized after enrollment into written advice and verbal advice arms 3. crc patients were asked to give the documents or verbal advice to fdr within 2 wks. 4. a telephone check was done to see if crc patients had given or sent the advice their fdr. 5. fdr were telephoned to see if they received the document and assessed their knowledge of fdr risk, screening methods, previous screening and other knowledge about crc. 6. fdrs were given information over the telephone about crc risk and screening and then asked whether they wanted to have screening or not.

Eligibility criteria:
inclusion criteria: * first degree relatives of patient with colorectal cancer exclusion criteria: * first degree relatives whom already diagnosed of colorectal cancer * first degree relatives whom have colorectal cancer from genetic disease

Keywords: colorectal cancer first degree relative cancer screening colonoscopy screening family history of colorectal cancer
effectiveness of uva1-irradiation in the treatment of early skin fibrosis in patients suffering from systemic sclerosis

Conditions: Systemic Scleroderma; Systemic Sclerosis

Summary: systemic scleroderma (ssc) is a rare chronic inflammatory diseae of the connective tissue involving the skin and internal organs. to date there is no proven therapy for the skin fibrosis available. a number of case reports and small uncontrolled cohort studies suggest that uva1 therapy may improve skin fibrosis. the aim of this study is therefore to investigate whether treatment uva1 in deed is effective in treating skin fibrosis in ssc using a randomized, intraindividual half body irradiation protocol.


Eligibility criteria:
inclusion criteria: * systemic sclerosis acr criteria * skin fibrosis at least involving the distal third of the lower arm exclusion criteria: * photosensitizing drugs * recent uv therapy

Keywords: systemic sclerosis skin fibrosis
physical activity interventions to heal chronic low back pain

Conditions: Chronic Low Back Pain

Summary: this study will advance understanding on the mechanisms that mediate improved outcomes for chronic low back pain and provide specific directions for optimizing physical activity interventions for this population.

in this study, participants with chronic low back pain will be randomized to receive a 12-week physical activity intervention (2 times per week with encouragement for home practice). the experimental condition will entail physical activity with components for strengthening emotion regulation skills, behaviors, and attitudes while the control condition will entail physical activity alone.

Eligibility criteria:
inclusion criteria: - age \> 18; report of low back pain \>3 of last 6 months; willing to attend 12-weeks of yoga or stretching (twice per week); willing to complete 4 assessments; english literacy; no changes in pain treatments in the past month; willing to not change pain treatments during study unless medically necessary; have not practiced yoga \> 2x in the last 12 months; exclusion criteria: - back surgery within the last 1 year; back pain due to specific systemic problem (e.g., lupus); lower extremity weakness (motor strength 4/5 of the quads, gluts, hamstrings, ehl); sciatica or (+) straight leg raise (slr); coexisting chronic pain problem (migraine headaches, fibromyalgia); serious or unstable psychiatric illness (e.g. psychosis, mania, history of suicide attempt); major coexisting medical illness (e.g., cancer, copd, morbid obesity); positive romberg test (with or without sensory neuropathy).

Keywords: chronic low back pain, physical activity, emotion regulation
non syndromic congenital heart defect and array-cgh in prenatal diagnosis

Conditions: Non Syndromic Congenital Heart

Summary: comparative genomic hybridization (cgh)-based microarrays are now often used during pregnancy in case of fetal polymalformation in order to assess significant genomic alterations. however, it is not clear whether array-cgh provide a diagnostic utility in case of isolated congenital heart defect. this is the first prospective study aiming at defining the right chromosomal screening when a fetal isolated congenital heart defect is identified by ultrasound.

comparative genomic hybridization (cgh)-based microarrays are now often used during pregnancy in case of fetal polymalformation in order to assess significant genomic alterations. up to now, in case of isolated heart defect, only fetal karyotype with fish 22q11 was usually offered. however, micro deletions or duplications could not be identified elsewhere throughout the genome. then, in case of fetal chromosomal micro-rearrangements, parents could not be fully informed for global and neurodevelopmental prognosis. to our knowledge, clear-cut study, to assess whether array-cgh provide a diagnostic utility in case of isolated congenital heart defect, don't exist. after informed consent, 80 women will be enrolled during two years in 2 official prenatal diagnosis centers in france. this survey is assumed to identify at least 8% of unbalanced chromosomal abnormalities. this will be also compared with 22q11 rearrangements rate. this is the first prospective study aiming at defining the right chromosomal screening when a fetal isolated congenital heart defect is identified by ultrasound.

Eligibility criteria:
inclusion criteria: * pregnant woman over 18-year-old ; * ongoing health insurance ; * informed consent ; * prenatal samples from amniotic fluid ; * isolated congenital heart defect. exclusion criteria: * transposition of great arteries ; * amniotic fluid sample refusal.
a study of two injection techniques to reduce pain in infants undergoing immunization

Conditions: Healthy Infants; Immunization; Pain Management

Summary: immunization injections are a significant source of pain for infants. tactile stimulation (rubbing/applying pressure) may be an effective and feasible pain-relieving intervention - it is cost neutral, and has been shown to be effective in children and adults undergoing injections. the aim of this study is to determine the added benefit of tactile stimulation when added to other proven analgesic interventions during routine infant immunization injections.

immunization injections are a significant source of pain for infants. at present, effective and feasible pain-relieving interventions include sugar water, fast injection without aspiration, and holding infants during the procedure. these methods, however, do not eliminate pain in all infants. additional interventions are therefore needed. tactile stimulation (rubbing/applying pressure) has been shown to reduce injection pain in children and adults, and may be a suitable intervention for infant injections. it is cost neutral, requires no preparation, and is easily incorporated into practice. the aim of this study is to determine the effectiveness of tactile stimulation when added to other proven analgesic interventions on reducing pain during infant immunization injections.

Eligibility criteria:
inclusion criteria: * infants 1-12 months of age receiving routine immunization injections in an outpatient pediatric clinic in toronto exclusion criteria: * impaired neurological development * history of seizure * use of topical anesthetics * use of sedatives or narcotics within 24 hours * fever or illness that would prevent administration of vaccine * prior participation in the trial

Keywords: immunization pain management infants tactile stimulation
pharmacokinetic and pharmacodynamic study of lenograstim for hematopoietic stem cell mobilization

Conditions: Multiple Myeloma

Summary: twenty four patients with multiple myeloma will be randomized to either am group (administration of lenograstim at 8 am) or pm group (administration of lenograstim at 6 am ). apheresis of hematopoietic stem cell will start at 10 am on d5 in am group and at 8 am on d4 in pm group, respectively. pharmacokinetic data of lenograstim will be correlated with pharmacodynamic data of cd34+ cell count, absolute neutrophil cell count and hematopoeitic progenitor cell count. in addition, the yield of stem cell collection between two arms will be analyzed.


Eligibility criteria:
inclusion criteria: * age: above 17 years, below 65 years old * informed consent * ecog 0-1 * autologous stem cell transplant candidate among patients with multiple myeloma exclusion criteria: * prior history of hematopoetic stem cell transplantation * history of failure to mobilize hematopoietic stem cells * history of g-csf administration within 2 weeks before enrollment to this study
a nurse-led intervention for fear of progression in advanced cancer

Conditions: Advanced Lung Carcinoma; Metastatic Malignant Female Reproductive System Neoplasm; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8

Summary: this clinical trial focuses on a nurse-led program that is designed to help patients cope with worries, fears, and uncertainty about the future. the purpose of this study is to understand if the program is helpful and practical to carry out at medical centers and community clinics. this study may help patients learn more effective ways to cope and respond to your concerns and any unhelpful thoughts.

primary objectives: i. to assess the feasibility and acceptability of the revised day by day (dbd) intervention in an academic and community settings. ii. to assess the preliminary effects of the revised dbd intervention for reducing fear of progression (fop) and improving distress, anxiety, depression, metacognitions (beliefs about worry), and mindfulness. outline: patients participate in 5 videoconference sessions over 30 minutes each over 6 weeks focused on worry management skills, values-based goal setting, and brief mindfulness-based practices, then complete patient workbook activities after each session over 15-20 minutes per day. patients also complete a survey over 8 minutes at 6 weeks, an exit interview at 7 weeks, and questionnaires over 25 minutes each at baseline, 6 weeks, and 10 weeks.

Eligibility criteria:
inclusion criteria: 1. patients with stage iii or iv gynecologic (gyn) or lung cancer 2. at least 3 months from initial diagnosis 3. score \>= 34 on the fear of progression-short form (sf) questionnaire exclusion criteria: 1. severe mental illness (e.g. psychosis) 2. hospice enrolled 3. non-english speaking