Kornimate/medical-research-clean huggingface dataset:
exergaming on hand dexterity in autistic children

Conditions: Autism Spectrum Disorder

Summary: through this study we aim to determine the effect of exergaming on bimanual hand dexterity in autistic children. this randomized controlled trial will recruit a sample of 20 autistic children as per the inclusion and exclusion criteria, through convenient sampling. the sample will be then randomly allocated to control group receiving the conventional dexterity training exercises and intervention group which will be receiving conventional plus exergaming intervention.

a study showed that a structured traditional physical activity intervention that targets specific ms resulted in motor function improvement in children with asd along with exergaming that can improve ef in children with asd. on a population of 20 patients with cp, structured neurodevelopmental therapy-based hand rehabilitation (sndtbhr) was applied and in the results positive effects of both interventions i.e. sndtbhr and lmbet were found. significant differences were found between lmbet and sndtbhr on ggf, pinch forces, jhft, and wcst all being in the favor of lmbet. exergaming interventions in the individuals with asd showed significant improvements in the physical fitness, executive functioning, and their self perception. exergaming increased the interest and participation of autistic children in moderate-to-vigorous physical activity. in contrast, exergaming had small impact on emotional regulation as per the results of another study participants with poorer dexterity in the beginning of exergaming training program greatly improved their dexterity performance, which also improved their quality of life. adherence and motivation increased significantly and system usability of the exergaming was acceptable. participants with impaired dexterity showed improvement in the nine-hole peg test and the pdq-39 according the researchers knowledge there have been numerous studies conducted on the effect of different exercise protocols on autistic children but there is lack of evidence in determining the effect of exergaming on specifically hand functioning/ dexterity in autistic population'. more studies should be done in order to check if exergaming or conventional treatment differ in their effect on hand dexterity in autistic children. home based exergaming and low cost video assisted games for dexterity need more in depth study so that they can be readily used by general public.

Eligibility criteria:
inclusion criteria: * male and female children pre-diagnosed with autism spectrum disorder. * autistic children who are compliant with exergaming exclusion criteria * children not pre-diagnosed with autism spectrum disorder * autistic children who have other coordination disorder such as developmental coordination disorder * autistic children with upper limb amputation. * autistic children with loss of vision

Keywords: autism spectrum disorder exergaming dexterity
the oral microbiome and upper aerodigestive squamous cell cancer

Conditions: Oral Cancer

Summary: the human oral cavity is a diverse habitat that contains approximately 700 prokaryotic species. the oral microbiome is comprised of 44% named species, 12% isolates representing unnamed species, and 44% phylotypes known only from 16s rrna based cloning studies (http://www.homd.org/). species from 11 phyla have been identified: firmicutes, bacteroidetes, proteobacteria, actinobacteria, spirochaetes, fusobacteria, tm7, synergistetes, chlamydiae, chloroflexi and sr1 (http://www.homd.org/). because these observations have been mainly based on data generated from traditional sanger sequencing, the diversity of oral microbiome is highly likely underestimated. application of high throughput sequencing to the oral microbiome similar to the scale of the microbiome studies of other body sites (gi tract, skin, and vagina) under the human microbiome project is necessary to obtain data essential for understanding the diversity and community structure of the oral microbiome in health and disease.

the prostate, lung, colorectal and ovarian (plco) cancer screening trial and the american cancer society cancer prevention study ii (cps-ii) investigators have identified 140 uadscc cases that have been frequency matched 3:1 (420 controls) by incidence density sampling for study (acs. plco), gender, ethnic background, and age, within 10 years.

Eligibility criteria:
inclusion criteria: * diagnosis of upper aerodigestive squamous cell cancer and registered in: * the american cancer society cancer prevention study ii (cps-ii) * the prostate, lung, colorectal and ovarian (plco) cancer screening trial.

Keywords: oral microbiome reflux disorders esophageal microbiome alcohol use tobacco use
alere mycobacterium tuberculosis urine study

Conditions: Tuberculosis

Summary: current molecular methods will be evaluated for the detection of mycobacterium tuberculosis specific nucleic acid in urine and blood of patients.


Eligibility criteria:
inclusion criteria: * suspected or confirmed tuberculosis * age \>18 years * informed consent obtained exclusion criteria: * previous participation in the study * simultaneous participation in a clinical trial investigating a new drug * inability to give consent * member of a vulnerable study population

Keywords: tuberculosis urine nucleic acid alere borstel
use of a foot length card to improve careseeking practices of vulnerable newborns in sarlahi district, nepal

Conditions: Low Birth Weight Babies; Preterm Babies

Summary: this study will evaluate whether or not provision of a simple card ("footlength card") that allows identification of low birth weight and/or preterm babies through measurement of the length of a baby's foot, can improve basic newborn care behaviors in rural nepal.

this study will evaluate a recently developed, simple, low-cost tool that can help recently delivered women and their family members identify whether or not their newborn baby needs extra care/attention. some prior studies of the relationship between anthropometric measures (such as chest-circumference, footlength, head circumference, etc) and preterm birth or low birth weight, have shown that these measures can be used to identify high-risk/vulnerable babies. one such measure, foot length, has been shown to be a reasonable tool, and one that can be simply performed by mothers, without disturbing the newborn infant. with this in mind, save the children has developed a low cost card with an image of a baby's foot on one side, along with a toll-free number and some key messages on how to use the card. specifically, pregnant women can be given this card during an antenatal contact, along with some basic instructions on its use. then, after their baby is born, the newly delivered woman, other family member, or low-level facility provider can compare the length of the baby's foot to the image on the card, by lining the baby's foot up with the card. if the baby's foot is shorter than the image on the card, a toll-free number (provided on the card itself) can be used to access a set of standardized messages about how to take care of the baby. in this proposed study, save the children, johns hopkins university (jhu), and the jhu-led nepal nutrition intervention project - sarlahi (nnips) will give this card to women currently enrolled in the nepal oil massage study (nct01177111), explain its use, follow up with the woman after delivery to determine if she used the card, and query her about her experience using the card, calling the toll-free number, and recalling the messages given. additionally, one of the nnips staff workers will use the same card to measure the baby's foot. ultimately, the study will summarize women's experience using this card, and provide guidance to save the children, the ministry of health and population (mohp), and other stakeholders regarding future programmatic scale up of the use of this card.

Eligibility criteria:
inclusion criteria: * woman is pregnant * woman is enrolled in ongoing newborn oil massage study exclusion criteria: * not pregnant * not enrolled in ongoing newborn oil massage study

Keywords: neonatal preterm nepal family-initiated identification basic newborn care
expressive writing in gvhd

Conditions: Graft Versus Host Disease

Summary: graft-versus-host-disease (gvhd) is a disease phenomenon that occurs when immune cells of the donor recognize and attack healthy tissue within the transplant recipient, or host. it is ultimately the result of the same immunological mechanisms that provide benefit to patients receiving hematopoietic stem cell transplantation (hsct). in patients with hematologic malignancies, hsct can be therapeutic, as donor t cells recognize and mount a response against cancerous cells. hsct is also used in the setting of certain immunodeficiencies and inborn errors of metabolism for which therapeutic benefit is found in immunologic repletion. to our knowledge, support groups have yet to be investigated in academic literature as a nonpharmacologic, therapeutic intervention for cutaneous gvhd patients to improve their distress, systemic disease, and quality of life. given the dearth of research on nonpharmacologic therapies for cutaneous gvhd that address quality of life impairments, we seek to characterize the effect of an expressive writing and peer helping intervention contextualized within the framework of a support group. the primary goal of this study is to provide preliminary efficacy data of expressive writing as an intervention in patients with cutaneous gvhd to trial.


Eligibility criteria:
inclusion criteria: * patients must have an active or previously diagnosed chronic cutaneous graft-versus-host disease (cgvhd). * patients must be age ≥18 years. * patients must be able to write using a utensil and paper or be able to type. * patients must have access to internet or cellular connectivity with sufficient bandwidth to participate in videoconferences (zoom). * patients should be able to and planning to attend all four live videoconferencing sessions for the support group via zoom. * patients must have the ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * patients with limited level of oral and written english.
effects of homemade oral nutrition supplements for patients on hemodialysis with protein-energy wasting

Conditions: Protein-Energy Wasting; Kidney Failure; Hemodialysis

Summary: the goal of this clinical trial is to learn if homemade oral nutrition supplements works to treat protein energy wasting in patients on hemodialysis. it will also learn about the cost-effectiveness of homemade oral nutrition supplements. the main questions it aims to answer are: * does homemade oral nutrition supplements improve the nutritional status of patients on hemodialysis with protein energy wasting? * what is the cost-effectiveness of homemade oral nutrition supplements? researchers will compare homemade oral nutrition supplements to commercial oral nutrition supplements to see if homemade oral nutrition supplements works to treat protein energy wasting in patients on hemodialysis. participants will: * take homemade or commercial oral nutrition supplements every day for 6 months * have assessment of nutritional status performed by researchers every three monthly


Eligibility criteria:
inclusion criteria: * on maintenance hd dialysis treatment (thrice weekly and 4-hour per session) for at least three months * age 18 - 70 year old * diagnosed with protein energy wasting using the malnutrition inflammation score (≥ 5) exclusion criteria: * a history of poor adherence to hd treatment (frequently miss the hd treatment for more than one session every month) * a history of frequent hospitalization (more than once in the past one month) * on regular oral nutrition supplements * diagnosed with malignancy * pregnant or lactating women * allergic to study products such as soy milk or milk

Keywords: hemodialysis protein-energy wasting kidney failure
mineralocorticoid antagonism to stop progression of atrial fibrillation (monitor-af) study

Conditions: Atrial Fibrillation

Summary: this proposal details the implementation of an international (singapore and new zealand) multi-centre study to test a novel therapeutic strategy aimed at reducing the burden of atrial fibrillation - an important medical condition with major healthcare implications. unique aspects of this study include i) a non-arrhythmic treatment target (mineralocorticoid receptor antagonism) -targeting the arrhythmogenic substrate of af before it becomes permanently established, ii) the use of pacemaker monitoring capability to accurately document af burden, thus increasing the power of the study and iii) multi-national collaborative, double blind design.


Eligibility criteria:
inclusion criteria: * age \> 21 years (without child-bearing potential for women); * with a permanent pacemaker capable of af monitoring; * device documented af in the last 12 months; defined as: i. atrial high rate events (ahre) \> 220 bpm for \>1% of the time; or ii. \> 6 mins on at least one occasion exclusion criteria: * persistent (defined as sustained af lasting continuously for 7 or more days) * history of heart failure with indication for mras * any existing clinical indication for mra or k+ sparing diuretic such as uncontrolled hypertension or oedema * contraindication to mra * severe renal dysfunction (egfr \<30ml/min by ckd-epi) * sustained hyperkalaemia (defined as k+ \>5mmol/l in the absence of reversible cause) * receiving af suppression pacing * women of child bearing potential * patients taking medications which may interact with the study drug or increase the level of potassium in the blood, include lithium, amiloride, cyclosporine, eplerenone, tacrolimus, and triamterene.
stabilization exercises with and without connective tissue massage for chronic mechanical neck pain

Conditions: Neck Pain Musculoskeletal

Summary: the aim of this study was to investigate and compared the effects of cervical and scapulothoracic stabilization exercises with and without connective tissue massage (ctm) for patients with chronic mechanical neck pain.

sixty patients with chronic mechanical neck pain were recruited and randomly allocated into stabilization exercise with and without the connective tissue massage program. the study's inclusion criteria were as follows: 18 to 65 years of age, having neck pain for more than 3 months, and being volunteer. the exclusion criteria were as follows: stenosis, traumatic injury history, previous surgery related to cervical spine, hypermobility, cancer, having inflammatory rheumatologic, severe psychological disorders, being pregnant, and intervention including exercise or physical therapy in the last 3 months.the program was carried out for 12 sessions, 3 days/week in 4 weeks. pain intensity with visual analog scale, pressure pain threshold with digital algometer, the level of anxiety with the spielberger state trait anxiety inventory, and life quality with short form-36 were evaluated before and after treatment.

Eligibility criteria:
inclusion criteria: * 18 to 65 years of age, * having neck pain for more than 3 months, and * being volunteer exclusion criteria: * stenosis, * traumatic injury history, * previous surgery related to cervical spine, * hypermobility, * cancer, * having inflammatory rheumatologic, * severe psychological disorders, * being pregnant, and * intervention including exercise or physical therapy in the last 3 months

Keywords: neck pain stabilization exercise connective tissue massage
a study to compare the efficacy of qav680 against placebo in treating seasonal allergic rhinitis in an environmental exposure chamber

Conditions: Seasonal Allergic Rhinitis

Summary: this study will compare the effectiveness of qav680 against placebo in treating the symptoms of seasonal allergic rhinitis in an environmental exposure chamber.


Eligibility criteria:
inclusion criteria: * positive skin prick test to ragweed allergen * fev1 must be ≥80% predicted value at screening and prior to entry into eec on day -2. * patients must weigh at least 50 kg, and must have a body mass index (bmi) within the range of 18 to 35 kg/m2. * non-smokers and ex-smokers (≤10 pack years and \>6 months of smoking abstinence). * understand and sign the written informed consent exclusion criteria: * patients requiring a change in the use of any prescription drugs within four (4) weeks prior to initial dosing. * participation in any clinical investigation within four (4) weeks prior to initial dosing or longer if required by local regulations, and for any other limitation of participation based on local regulations. * significant illness within two (2) weeks prior to initial dosing. * history of immunodeficiency diseases, including a positive hiv (elisa and western blot) test result. * a positive hepatitis b surface antigen (hbsag) or hepatitis c test result. other protocol-defined inclusion/exclusion criteria may apply

Keywords: seasonal allergic rhinitis environmental exposure chamber nasal lavage
moving - motivation, intervention and vascular change

Conditions: Endothelial Function (Reactive Hyperemia)

Summary: background: the impact of demographic changes on workplace has increased the importance of effective occupational preventive health programs. the primary goal of these programs is the improvement of overall health status (and therefore increase productivity and decrease healthcare costs) of the increasingly older workforce through positive lifestyle behavior change. a one- year preventive health behavior-change program for the employees of the company british petrol (bp) shall be scientifically evaluated. the initial stage of the program consists of a health-behavior seminar and six weeks (twice a week for 90 minutes) of supervised endurance exercise (i.e. jogging, nordic walking, cycling or swimming) in groups. in the second phase of the program, the participants receive a recommendation to continue exercise regularly unsupervised for one year, and receive monthly supervised exercise training sessions. clinical check-ups are performed at baseline (v1) at three months (v2) and at 12 months (v3).

the study will investigate the effect of one year of participation in a lifestyle- intervention- program on the participants' metabolic risk profile, exercise capacity and vascular health. a primary focus is on the endothelium, because poor endothelial health is a risk factor and prognostic indicator of atherosclerosis and cardiovascular events. hypothesis: one year of participation in endurance exercise (twice a week for 90 minutes) may positively influence endothelial health (rhi) the primary aim: change in endothelial function (reactive hyperemia index (rhi)) after one year. secondary aims: changes in other vascular parameters (ai: augmentation index, cavi: cardio ankle vascular index, abi: ankle brachial index ), changes in anthropometric, inflammatory and metabolic parameters, exercise capacity (watt/kg), physical activity, and health related quality of life (hrqol).

Eligibility criteria:
inclusion criteria: * employees of the company british petrol (bp) in lingen, germany * men and woman of all age * approval for being able to participate in physical activity * existing, written agreement to study-participation with prior, detailed education exclusion criteria: * acute or chronic disease of any kind, which does not allow participation in physical activity (missing approval of being able to participate in physical activity) * incompetent patient, who is not able to understand character, meaning and consequences of the study

Keywords: lifestyle physical activity endothelial function cardiovascular occupational prevention
effect of oxytocin on craving and therapy response

Conditions: Marijuana Dependence

Summary: the purpose of this study is to examine the impact of a medication called oxytocin on marijuana use and therapy response in people who frequently use marijuana.

oxytocin has been shown to promote trust, social bonding, and calmness; however, its potential additive effects with a therapy intervention have not been explored in marijuana-dependent individuals. in the proposed study, the impact of intranasal oxytocin on therapy effectiveness and marijuana use outcomes following a brief therapy intervention will be investigated. it is hypothesized that oxytocin administration (vs. placebo) will improve treatment satisfaction and decrease marijuana use.

Eligibility criteria:
inclusion criteria: 1. subjects must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments. 2. subjects must meet dsm-iv criteria for current marijuana dependence (within the past three months). while individuals may also meet criteria for abuse of other substances, they must identify marijuana as their primary substance of abuse and must not meet criteria for dependence on any other substance (except nicotine) within the last 60 days. 3. subjects must consent to remain abstinent from alcohol for 24 hours and other drugs of abuse (except nicotine and marijuana) for three days immediately prior to study procedures. subjects must abstain from marijuana for 24 hours prior to testing. by restricting marijuana use as proposed, subjects should not be under the acute effects of marijuana. 4. subjects must consent to random assignment. exclusion criteria: 1. women who are pregnant, nursing or of childbearing potential and not practicing an effective means of birth control. 2. subjects with evidence of or a history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal, or neurological disease including diabetes, as these conditions may affect physiological/subjective responses. 3. subjects with a history of or current psychotic disorder or bipolar affective disorder as these may interfere with subjective measurements. 4. subjects who pose a current suicidal or homicidal risk. 5. subjects taking any psychotropic medications, including sri's or other antidepressants, opiates or opiate antagonists because these may affect test response. individuals who take stimulants for treatment of adhd will be allowed to participate. 6. subjects with any acute illness or fever. individuals who otherwise meet study criteria will be rescheduled for evaluation for participation. 7. subjects who are unwilling or unable to maintain abstinence from alcohol and marijuana for 24 hours and other drugs of abuse (except nicotine) for three days prior to study procedures. 8. subjects meeting dsm-iv criteria for substance dependence (other than nicotine or marijuana) within the past 60 days. 9. subjects who, in the investigator's opinion, would be unable to comply with study procedures or assessments.

Keywords: marijuana substance abuse drug abuse marijuana dependence drug addiction
exercise with blood flow restriction in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the purpose of this study is to evaluate the neuromuscular responses, pain intensity and rate of perceived exertion in patients with severe knee osteoarthritis in a preoperative setting with low-load resistance training with blood flow restriction at different levels of arterial occlusion pressure.


Eligibility criteria:
inclusion criteria: * men and women above 55 years old. * diagnosed with severe knee osteoarthritis. * scheduled for unilateral tka surgery in a local hospital during 2021- 2022. exclusion criteria: * pain in the contralateral limb (maximum pain, ≥80 of 100 mm on a vas during daily activities). * another hip or knee joint replacement in the previous year. * any medical condition in which exercise was contraindicated. * participated in exercise programs (\>2 days/week, training at intensities of 10-15rm) in the 6 months prior to the study. * history of stroke, brain surgery, major depression, or any self-perceived cognitive alterations that could affect the performance of dual tasks.

Keywords: knee osteoarthritis electromyography muscle activity resistance training