Kornimate/medical-research-clean huggingface dataset:
clinical presentation and outcome of copd patients with acute exacerbation attending sohag university hospital

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is a worldwide public health challenge because of high prevalence and related disability and mortality (1). acute exacerbation of copd (aecopd), defned as the worsening of respiratory symptoms and requirement of additional clinical treatment, it reduces lung function and quality of life, and is accompanied by an increased disease-related burden, high hospital mortality and poor outcome (2). chronic obstructive pulmonary disease frequently coexists with other chronic diseases, namely comorbidities. they negatively impact prognosis, exacerbations and quality of life in copd patients. local and systemic inflammation have been proposed as having a potential role in explaining the association between copd and these comorbidities (3).


Eligibility criteria:
inclusion criteria: patients with a confirmed copd diagnosis according to (gold) guidelines, presented with acute exacerbation exclusion criteria: * stable copd * any other chronic chest diseases; bronchial asthma or bronchiectasis
cerebral bloodflow and carbondioxide reactivity during mild therapeutic hypothermia in patients after cardiac arrest

Conditions: Cardiac Arrest; Post-Anoxic Encephalopathy

Summary: survivors of a cardiac arrest frequently develop severe postanoxic encephalopathy. derangements in cerebral blood after return of spontaneous circulation play an important role in the pathogenesis of postanoxic encephalopathy. in the present study we examine the effect of mild therapeutic hypothermia on cerebral blood flow and carbondioxide reactivity in patients after cardiac arrest.


Eligibility criteria:
inclusion criteria: * adult patients * gcs after return of circulation \< 7 * induced mild hypothermia for 24 hours * primary rhythm ventricular fibrillation exclusion criteria: * thrombolysis * cardiogenic shock with expected survival \< 24 hrs * pregnancy * no informed consent
gravitational arrhythmogenesis can the often-heard symptom of body position dependent palpitations be proven

Conditions: Cardiac Complexes, Premature; Atrial Fibrillation

Summary: this study aims to assess the relationship between body position and the occurrence of either atrial or ventricular premature beats and more complex arrhythmia

rationale: palpitations in a certain body position is an often-heard symptom, although there is currently no direct evidence that links body position with arrhythmia. the hypothesis is that arrhythmia is more prevalent in the specific body position that the patient reports to be arrhythmogenic. objective: the objective of this study is to assess the relationship between body position and the occurrence of either atrial or ventricular premature beats and more complex arrhythmia (at, atrial fibrillation (af), vt) in a population that have a self-reported preferential body position for symptoms. study design: single cohort study. subjects are recruited from the outpatient clinic. first, they will fill in a short questionnaire regarding their symptoms; second, they will be outfitted with a downgraded polygraphy device, that only monitors body position, and single and/or multi lead ecg for 24 hours. the acquired data will be analyzed at the catharina hospital and the eindhoven university of technology. study population: outpatients with palpitations and a self-reported higher prevalence in a certain body position that have an indication to undergo holter monitoring, independent of any previous diagnosis. main study parameters/endpoints: the frequency of ectopic beats or onset of complex arrhythmia (n per minute) in the body position that the patient has reported as arrhythmogenic, compared to arrhythmia rate in the other body positions, corrected for time spent per body position.

Eligibility criteria:
inclusion criteria: * palpitations, spontaneously described to occur either predominantly or solely in a certain body position (upright, prone, supine, left or right lateral decubital position). * ability to provide informed consent exclusion criteria: * there are no exclusion criteria for this study.

Keywords: body position
fmri accelerated tms depression

Conditions: Depression

Summary: this study aims to investigate whether phenotypic-related brain states revealed by a novel inscape ("individualized network-based single-frame coactivation pattern estimation") neuroimaging method in major depressive disorder (mdd) patients can track brain recovery of mdd patients over an accelerated antidepressant transcranial magnetic stimulation (tms) treatment.

the aim of this study is to use magnetic resonance imaging (mri) to capture images of participants' brains and apply an image processing method called inscape to assess brain states. this study will recruit participants who are scheduled to receive accelerated transcranial magnetic stimulation (tms) therapy for major depressive disorder (mdd). participation in this study involves two visits, each including a 30-minute mri scan. the interval between each visit is about one week. depressed participants will also complete mood assessments at various intervals while they are receiving accelerated tms for depression.

Eligibility criteria:
inclusion criteria: * age 18-65 * have the capacity and ability to provide one's own consent in english and sign the informed consent document. * dsm-iv diagnosis of mdd exclusion criteria: * unable to speak english. * contraindicated for mri. * any current or recent untreated medical, neurological, or psychiatric conditions * metal implant devices in the head, heart, or neck. * history of brain surgery. * history of cortisol medication use or electroconvulsive therapy. * comorbidity with other psychiatric/neurological illnesses or personality disorders * history of myocardial infarction or arrhythmia, bradycardia. * personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury. * individuals suffering from frequent/severe headaches. * moderate to severe alcohol or substance use disorder. * pregnancy

Keywords: brain depression
ultrasensitive electroanatomic mapping to adjudicate endpoints for ablation in paroxysmal af patients using cryoballoon

Conditions: Paroxysmal Atrial Fibrillation

Summary: ultrasensitive electroanatomic mapping to adjudicate endpoints for ablation in paroxysmal af patients using cryoballoon

collected data include procedural parameters relevant to pulmonary vein isolation as outlined in the protocol section, de identified patient demographics, follow up information including rhythm status, antiarrhythmic medication usage, and symptoms or signs to suggest procedural complications relevant to the pulmonary vein isolation procedure.

Eligibility criteria:
inclusion criteria: * patients undergoing pulmonary vein isolation using cryoballoon at st. joseph's hospital in fl that sign informed consent exclusion criteria: -
bioequivalency study of imipramine pamoate 75 mg capsules under fasted conditions

Conditions: Depression

Summary: the objective of this study was to prove the bioequivalence of imipramine pamoate 75 mg capsules under fasting conditions


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enzyme altering drugs. * history of allergic or adverse response to imipramine pamoate or any comparable or similar product.
obstructive sleep apnea and bronchoscopy

Conditions: Obstructive Sleep Apnea of Adult

Summary: the prevalence of sleep-disordered breathing in republic of korea is 27% and 16% in men and women aged 40-69 years. up to 93% of women and 82% of men with obstructive sleep apnea (osa) remain undiagnosed. polysomnography, the gold standard, is time consuming and costly. patients with undiagnosed osa may experience obstructive episodes during procedures with conscious sedation. stop-bang questionnaire is the validated questionnaire to screen patients for undiagnosed osa in the preoperative setting. it has high sensitivity (92.9%) for predicting patients with moderate to severe osa. previous studies reported that stop-bang questionnaire predicted cardiopulmonary events during advanced endoscopic procedures such as endoscopic retrograde cholangiopancreatography (ercp) and endoscopic ultrasound. however, there have been no studies regarding the risk for sedation-related cardiopulmonary events in patients with undiagnosed osa undergoing bronchoscopy. thus, we aimed to evaluate the prevalence of high-risk patients for osa by a screening questionnaire, and to determine whether the questionnaire could predict patients who are at risk for cardiopulmonary events during bronchoscopy with conscious sedation.


Eligibility criteria:
inclusion criteria: * patients who are18 years or order undergoing bronchoscopy with conscious sedation in the bronchoscopy center exclusion criteria: * previous diagnosis of osa * american society of anesthesiologists physical status classification system score \> 3 * baseline spo2 \< 90% or need for supplemental oxygen before the procedure * tracheostomy tubes * an inability to provide informed consent * undergoing the procedure based on an outpatient clinic * undergoing bal, ebus-tbna, and interventional bronchoscopy * allergies or sensitivities to sedative medications * pregnant

Keywords: obstructive sleep apnea bronchoscopy stop-bang questionnaire cardiopulmonary events
a study of the effects of an employee wellness program

Conditions: Obesity

Summary: ochsner employees with a body mass index (bmi) greater than or equal to 30 will be enrolled in a fitness program consisting 90 days of a structured exercise program and dietary counseling. measures of fitness including weight, bmi, cholesterol, hdl, blood pressure, and absenteeism rates will be measured at 0, 90 days, in one year.


Eligibility criteria:
inclusion criteria: * ochsner employees with a bmi greater than or equal to 30 exclusion criteria: * failure to pass initial physical exam
to evaluate safety and tolerability after multiple oral doses of azd1656 in type 2 diabetes patients on top of metformin

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to assess safety and tolerablility of azd1656 after multiple repeated oral doses in patients with type 2 diabetes on top of metformin.


Eligibility criteria:
inclusion criteria: * male or female (with non child-bearing potential) * diagnosed diabetes mellitus patients treated with metformin alone or one other anti-diabetic drugs. stable blood sugar control indicated by no changed treatment within 3 months prior to study start.t * hba1c \<11 % at screening (hba1c value according to international dcct standard) exclusion criteria: * clinically significant illness or clinically relevant trauma, as judged by the investigator, within two weeks before the first administration of the ip * history of ischemic heart disease, stroke, transitorisk ischemic attack or symptomatic peripheral vascular disease * clinically significant abnormalities in clinical chemistry, hematology, or urinalysis results.

Keywords: type 2 diabetes
gemcitabine plus s1 and tislelizumab in the first line therapy of advanced biliary tract carcinoma

Conditions: Biliary Tract Carcinoma

Summary: this study will evaluate the efficacy and safety of 1st line therapy with gemcitabine plus s1 and tislelizumab in participants with advanced biliary tract carcinoma (btc).


Eligibility criteria:
inclusion criteria: * 1. age ≤ 18 years old ≤ 75 years old, regardless of gender. * 2. diagnosed as malignant tumor of biliary tract by histopathology or cytology, including intrahepatic cholangiocarcinoma, hilar cholangiocarcinoma, common bile duct carcinoma or gallbladder carcinoma. * 3. the disease is not suitable for radical surgery and/or local treatment; * 4. at least one measurable lesion according to recist 1.1 standard * 5. the ecog score is 0-1 * 6. the expected survival ≥ 12 weeks. * 7. the child-pugh score is 5-7 * 8. within the past 2 years, there was no active autoimmune diseases that require systemic treatment, replacement therapy (such as thyroid hormone, insulin, or physiological corticosteroid replacement therapy for adrenal or pituitary dysfunction) * 9. women with fertility: agree to abstain during treatment and at least 6 months after the last dose (to avoid heterosexual intercourse) or use contraceptive methods with an annual contraceptive failure rate of less than 1%. * 10. male: agree to abstain (not engage in heterosexual intercourse) or use contraception, agree not to donate sperm * 11. the subjects voluntarily participated in the study and agreed to sign written informed consent, with good compliance and cooperation in follow-up. exclusion criteria: * 1. who have any of the following: (1) suitable for surgical radical treatment, (2) have undergone radical surgery without assessable lesions, (3) have received first-line systemic treatment * 2. known to be allergic or intolerant to recombinant humanized pd-1 monoclonal antibody drugs and their components. * 3. ecog ps ≥ 2 * 4. metastasis site\>2 organs * 5. pregnant or lactating women * 6. received local anti-tumor therapy within 4 weeks prior to the first study drug treatment, including but not limited to radiotherapy, radiofrequency ablation, cryoablation, or percutaneous ethanol injection * 7. receiving approved or developing systemic anticancer therapies, including chemotherapy, biological immunotherapy, targeted therapy, or chinese herbal therapy with clear indications for anti-tumor effects * 8. there are multiple factors that can affect the oral administration of s1 (such as inability to swallow, chronic diarrhea, intestinal obstruction, or other conditions that significantly affect drug administration and absorption) * 9. simultaneously participating in another clinical study * 10. after comprehensive assessment of the condition by the investigators, it is deemed unsuitable to participate in this study
applying pulsed radiofrequency to the pudendal nerve bilaterally vs its application to sacral nerve roots s2,3 and 4 bilaterally in chronic prostatitis

Conditions: Prostatitis; Pulsed Radiofrequency

Summary: prevalence estimates show that prostatitis is one of the most common urological conditions and that symptoms range considerably among men of various socioeconomic status, race, and age. for men under 50 years, prostatitis is the most common urologic outpatient diagnosis. chronic prostatitis/chronic pelvic pain syndrome has high prevalence estimates internationally ( 16% north america, 14% asian \& europeans). men suffering from chronic prostatitis/chronic pelvic pain syndrome report significant impairment in their quality of life which is also associated with greater health care expenditures.

the hallmark indicator of chronic prostatitis/chronic pelvic pain syndrome has been identified as enduring pain in the perineum, pelvic area, and/or genitalia in many studies. as in other painful chronic conditions, pain does not correspond strongly with objective medical findings and has no orthodox pathology. it is however associated with voiding and sexual disturbances. symptoms should have been present for at least 3 months within the previous 6 months and must be validated with the standard questionnaire of the national institute of health-chronic prostatitis symptom index. in most patients, pain is the main symptom. chronic bacterial prostatitis the predominant type of prostatitis is a common and painful condition, typified by pelvic area pain and lower urinary tract symptoms, for which effective diagnostic techniques and treatment strategies remain elusive. previous studies have documented an association between prostatitis and both psychiatric and rheumatologic diseases. socioeconomic status indicators, such as lower education and lower income, also played an important role in predicting which men would have worse chronic prostatitis symptoms. these findings are consistent with those found among women with interstitial cystitis; women with lower education and income in the interstitial cystitis database were more likely to report more severe symptoms.

Eligibility criteria:
inclusion criteria: * asa physical status i-iii. exclusion criteria: * those with infection at the site of injection, * coagulopathy or another bleeding diathesis, * a pre-existing neurologic deficit in the targeted region,

Keywords: pulsed radiofrequency chronic prostatitis
diagnosis and treatment of urinary tract infection using dna polymerase chain reaction versus urine culture

Conditions: Urinary Tract Infections

Summary: adults 18 years or older with urinary tract infection (uti) symptoms. participants will be assigned to either the urine culture group or the dna pcr study group by randomization. at time of enrollment in the study they will be also asked to fill out two questionnaires. if prescribed antibiotics for treatment of a uti, participants will then be called the day after they are scheduled to stop their antibiotics. participants will be asked to fill out questionnaires the day after finishing antibiotics. participants will be enrolled in the study for a maximum of 21 days.


Eligibility criteria:
inclusion criteria: * adult men and women 18 years and older * presenting to clinic with symptoms of uti or cystitis * patients with medicare and medicaid insurance exclusion criteria: * urinary diversion of any type * chronic indwelling urinary catheter * diagnosed uti within the previous 21 days * antibiotic therapy within the previous 21 days * use of phenazopyridine within the previous 21 days * commercial insurance * non-english speaking * pregnant patients

Keywords: urine culture dna pcr
oxygen reserve index: utility as early warning for desaturation in morbidly obese patients

Conditions: Morbid Obesity; Surgery

Summary: the oxygen reserve index (ori) is a reference that could help clinicians with their assessments of normoxic and hyperoxic states by scaling the measured absorption information between 0.00 and 1.00. an ori of 0.00 corresponds to partial pressure of oxygen (pao2) values of 100 mmhg and below and an ori of 1.00 corresponds to pao2 values of 200 mmhg and above. this is clinical study designed to evaluate the clinical utility of the oxygen reserve index (ori) as an early warning for arterial hemoglobin desaturation during the induction of general anesthesia and tracheal intubation in obese patients undergoing elective surgical procedures.


Eligibility criteria:
inclusion criteria: * age greater than 18 years * bmi\>30, \<40 m/kg2 * control group only: bmi \>18.5 m/kg2, \<25 m/kg2 * scheduled for an elective surgical procedure requiring general anesthesia and endotracheal intubation exclusion criteria * age less than 18 years * adults unable to give primary consent * pregnancy * prisoners

Keywords: oxygen desaturation obesity
troponin in acute chest pain to risk stratify and guide effective use of computed tomography coronary angiography

Conditions: Coronary Artery Disease

Summary: most patients presenting to hospital with symptoms of a heart attack are sent home without further tests once a heart attack has been ruled out. current strategies to assess patients with a suspected heart attack involve blood tests to measure troponin, a protein released into the bloodstream when the heart muscle is damaged. despite having had a heart attack ruled-out, some patients have unrecognised heart disease and are at risk of having a heart attack in the future. however, clinicians do not know what is the best approach to identify and treat these patients. this study will use a heart scan known as computed tomography coronary angiogram (ctca) to look for unrecognised heart disease in patients who have had a heart attack ruled out. in an earlier study, the investigators performed this scan in patients referred to the outpatient cardiology clinic with stable chest pain and found that this improved the diagnosis of heart disease, leading to improvement in patient care that prevented future heart attacks. previous research from the investigators has also found that troponin levels below those used to diagnose a heart attack may help to identify those who are at greater risk of having a heart attack in the future. the aim of this study is to find out if patients with these low levels of troponin, where a heart attack has been ruled out, will benefit from ctca to look for unrecognised coronary heart disease.


Eligibility criteria:
inclusion criteria: * presenting to hospital with symptoms of suspected acute coronary syndrome * age 18 years and over * maximum high-sensitivity cardiac troponin concentration between 5ng/l and the 99th percentile exclusion criteria: * diagnosis of myocardial infarction during index presentation * clear alternative diagnosis or participant requires further inpatient clinical assessment * recent ctca or invasive coronary angiogram (within 1 year) * patient inability to undergo ct scanning, e.g. due to severe renal failure (estimated glomerular filtration rate \<30 ml/min) or major allergy to iodinated contrast media * current pregnancy or breast feeding * inability to give informed consent * further investigation for coronary artery disease would not be in the patient's interest, e.g. due to limited life expectancy, quality of life or functional status * previous randomisation into the trial