the effects of a nutritional supplement on nutrient status and quality of life

Conditions: Nutrition, Healthy; Gastrointestinal Microbiome; Healthy Aging

Summary: this study is a randomized, double-blind, placebo-controlled study of n=120 apparently healthy men and women. the purpose of this study is to assess the effect of a novel dietary supplement on blood markers of nutrient status, gut microbiome, and overall quality of life.


Eligibility criteria:
inclusion criteria: * provide voluntary signed and dated informed consent. * no known history of chronic illness or disease. * aged between 18 and 59.9 years (inclusive). * body mass index of 20-34.9 (inclusive). * willing to duplicate their previous 24-hour diet, refrain from caffeine and exercise for 24 hours, and fast for 10 hours prior to each quest visit. * agree to maintain existing dietary and physical activity patterns throughout the study period. * willing and able to comply with the study protocol. exclusion criteria: * history of unstable or new-onset cardiovascular, liver, or renal conditions. * history of diabetes or endocrine disorder. * multivitamin/multimineral supplement consumption within the past 3 months. * regular consumption (i.e., at least five days/week) of resveratrol, quercetin, pterostilbene, coq10, grapefruit, nicotinamide riboside, probiotics, prebiotic fiber, green tea, niacin (vitamin b3), or products meant to promote "healthy aging" or "anti-aging" or "longevity" in the 2 months prior to screening as well as throughout the study. * subjects who have received an antibiotic, antifungal, antiparasitic, or antiviral treatment within 90 days prior to study. * history of use of medications or dietary supplements known to confound the study or its endpoints. * excessive alcohol consumption (more than 2 standard alcoholic drinks per day or more than 10 drinks per week) or drug abuse or dependence within the past 6 months. * current smokers or smoking within the past month. * history of hyperparathyroidism or an untreated thyroid condition. * history of malignancy in the previous 5 years except for non-melanoma skin cancer (basal cell cancer or squamous cell cancer of the skin). * prior gastrointestinal bypass surgery (lapband, etc.). * other known gastrointestinal or metabolic conditions that might impact nutrient absorption or metabolism, e.g., short bowel syndrome, ibs/ibd, diarrheal illnesses, history of colon resection, gastroparesis, inborn errors of metabolism (such as pku). * chronic inflammatory condition (e.g., rheumatoid arthritis, crohn's, ulcerative colitis, lupus, hiv/aids, etc.). * previous medical diagnosis of asthma, gout, or fibromyalgia. * pregnant women, women trying to conceive, women less than 120 days postpartum, or nursing women. * a change in hormone therapy, including oral contraceptives, within 4 weeks prior to screening, or unwilling to maintain current hormone therapy/oral contraceptive use throughout the course of the study. * known allergy or sensitivity to any ingredient in the test formulations as listed in the product label. * currently participating in another research study with an investigational product or have been in another research study in the past 30 days. \>10% weight change in the last 6 months. - specific exclusion type diets like vegan, vegetarian, carnivore, paleo, atkins, ketogenic etc.