Kornimate/medical-research-clean huggingface dataset:
home visitation enhancing linkages project

Conditions: Substance Use

Summary: a small pilot randomized controlled trial (rct) will be conducted to test the impact of an electronic screening and brief intervention (e-sbi) on reduction in substance use (measured via self-report), associated symptoms (depression and parenting stress), and improvement in home visiting retention and substance use treatment engagement. while a pilot rct was originally planned, the study experienced significant delays and recruitment challenges due to the covid-19 pandemic. therefore, after review by the dsmb and study sponsor, the decision was made to eliminate the randomization and assign all participants to the intervention condition to evaluate feasibility and acceptability of the intervention.

the purpose of this clinical trial is to pilot test an electronic screening and brief intervention (e-sbi) that will be adapted for use with pregnant and postpartum women in home visiting (hv) programs. the e-sbi will be tested in a small randomized trial in two home visiting sites, with 20 home visitors and 40 clients. home visitors will be randomized to the control intervention or the e-sbi. clients will be surveyed at baseline, and 3- and 6- month follow-up to track e-sbi impacts on reduction in substance use (measured via self-report), associated symptoms (depression and parenting stress), and improvement in home visiting retention and substance use treatment engagement. while a pilot rct was originally planned, the study experienced significant delays and recruitment challenges due to the covid-19 pandemic. therefore, after review by the dsmb and study sponsor, the decision was made to eliminate the randomization and assign all participants to the intervention condition to evaluate feasibility and acceptability of the intervention. total enrollment was n = 14. four participants were assigned to the control condition prior to elimination of randomization. the remaining 10 participants were assigned to the intervention condition. primary study outcomes were feasibility and acceptability.

Eligibility criteria:
inclusion criteria: * english-speaking, * 18 years or older, * pregnant or up to 3 months postpartum, * newly enrolling in home visiting with a participating home visitor, * not currently attending substance use treatment exclusion criteria:
the association between body constitution and meridian energy in prediabetes

Conditions: Prediabetes

Summary: traditional chinese medicine (tcm) theories assert that body constitution and meridian energy are the foundations for disease prevention. however, few studies have incorporated tcm concepts into risk factors. this study aimed to examine the association between body constitution and meridian energy in individuals with prediabetes. we conducted a matched case-control study that included 60 individuals with prediabetes. finally, the reseachers have found that body constitution may be a risk factor fpr progression to type 2 diabetes mellitus in individuals with prediabetes.

objective: traditional chinese medicine (tcm) theories assert that body constitution and meridian energy are the foundations for disease prevention. however, few studies have incorporated tcm concepts into risk factors. this study aimed to examine the association between body constitution and meridian energy in patients with prediabetes. methods: the researchers conducted a matched case-control study from january to december 2019 that included 30 adults with prediabetes and 30 healthy controls, matched for age and sex, recruited from the outpatient clinic and health examination center at a teaching hospital in northern taiwan. body constitution was measured using the body constitution questionnaire, which classifies the constitution as yang-deficiency, ying-deficiency, and phlegm-stasis, while meridian energy was measured using an aetoscan meridian energy device (aeto technology co. ltd., taiwan). the associations between body constitution, meridian energy, and prediabetes were examined using binary logistic regression analyses. conclusion: body constitution may be a risk factor for progression to type 2 diabetes mellitus in patients with prediabetes and warrants further study.

Eligibility criteria:
inclusion criteria: * previously diagnosed prediabetes with a hemoglobin a1c (hba1c) of 5.7-6.4% and a f asting plasma glucose (fpg) of 100-125 mg/dl * aged ≥20 * provided informed consent * the controls were healthy individuals whose fpg level was 100 mg/dl in at least two blood tests in the past 6 months. exclusion criteria: * use of a hypoglycemic agent within the past 3 months * self-reported catastrophic illness in the last 6 months * pregnant and/or lactating * presence of pacemaker.

Keywords: prediabetes traditional chinese medicine body constitution
evaluation of the safety and immunogenicity of sequential administration of prevnar 13™ and pneumovax™ 23 in healthy participants 50 years of age and older (v110-029)

Conditions: Pneumococcal Infections

Summary: the purpose of this study is to evaluate the safety and immunogenicity of sequential administration of prevnar 13™ and pneumovax™ 23 in healthy participants 50 years of age and older. the primary hypotheses in the study are that 1) geometric mean titers (gmts) to pneumococcal serotypes 22f and 33f (serotypes in pneumovax™ 23 but not in prevnar 13™) as measured at week 12 are superior in participants administered prevnar 13™ on day 1 and pneumovax™ 23 at week 8, as compared with participants administered prevnar 13™ on day 1 and placebo at week 8 and 2) gmts to pneumococcal serotypes shared by the two vaccines as measured at week 12 are non-inferior in participants administered prevnar 13™ followed by pneumovax™ 23 as compared with participants administered prevnar 13™ followed by placebo.


Eligibility criteria:
inclusion criteria: * any chronic illness must be documented to be in stable condition * male, or a female agrees to remain abstinent, or use, or have their partner use, 2 acceptable methods of contraception through 6 weeks after receiving study vaccination; or a female who is not of reproductive potential exclusion criteria: * is or has an immediate family member who is investigational site or sponsor staff directly involved with this trial * prior administration of any pneumococcal vaccine * history of invasive pneumococcal disease * known hypersensitivity to any component of the pneumococcal polysaccharide vaccine, of the pneumococcal conjugate vaccine, or any diphtheria toxoid-containing vaccine * known or suspected impairment of immunological function, documented human immunodeficiency virus (hiv) infection, asplenia, or history of autoimmune disease * received systemic corticosteroids (equivalent of \>=2 mg/kg total daily dose of prednisone or \>=20 mg/kg for persons weighing \>10 kg) for \>=14 consecutive days and has not completed treatment \<=30 days before study vaccination, or has received systemic corticosteroids exceeding physiological doses (\~5 mg/day prednisone equivalent) within 14 days before study vaccination (topical, ophthalmic, intra-articular, and inhaled/nebulized steroids are permitted). * has a coagulation disorder contraindicating intramuscular vaccination * receiving immunosuppressive therapy, including chemotherapeutic agents used to treat cancer or other conditions, and treatments associated with organ or bone marrow transplantation or autoimmune disease * received a blood transfusion or blood products, including immunoglobulins \<=6 months before receiving study vaccine, or is scheduled to receive them within 30 days * participated in another clinical study of an investigational product \<=2 months before or during the current study * is breast-feeding
short term effects of increasing sleep duration

Conditions: Overweight and Obesity

Summary: a series of studies are proposed to develop an intervention to increase sleep duration and study the effects on eating, exercise, and weight control. the hypothesis is that increasing sleep duration will help improve weight loss and maintenance.

study 1 is conducted in a sleep laboratory. participants sleep short duration (approximately four hours per night) on one weekend and long duration (approximately nine hours per night) on another weekend. study 2 is examining ways to increase sleep duration in overweight individuals with short sleep and examining the effects on short term weight loss. study 3 is comparing a standard weight loss program with a novel sleep+weight loss intervention.

Eligibility criteria:
inclusion criteria: * age 25 to 45; * bmi 25 to 50; * healthy; * sleep 6.5 hours or less per night exclusion criteria: * use of sleep medications; * sleep apnea; * third shift worker

Keywords: weight loss sleep duration
validity of pleural effusion detection software

Conditions: Pleural Effusion

Summary: the chang gung pleural effusion detection software is a medical software that can automatically detect whether there is a pleural effusion in chest x-ray. the purpose of this study is to verify whether the chang gung pleural effusion detection software can correctly identify patients with pleural effusion in chest x-ray. the results of the software analysis will be used for the performance of the software on the primary and secondary outcomes.

this clinical trial is a retrospective study. dicom images of de-identified chest x-ray were collected from 6 hospitals of chang gung memorial hospital from january 1, 2018 to december 31, 2020. after confirming that the chest x-ray that meet the inclusion and exclusion criteria are correct, 282 samples will be sampled for this test, including 141 images with pleural effusion and 141 images without pleural effusion. the image must be in dicom format. then, 3 specialists physicians interpret 282 samples whether there were pleural effusion, and the result was the standard of this study (reference standard). after determining the reference standard of each chest x-ray, the 282 samples were input into the chang gung pleural effusion detection software, and analyzed by the primary and secondary outcomes.

Eligibility criteria:
inclusion criteria: * the case were over 20 years old and under 100 years old. * dicom format. * brand model of canon. * dicom resolution length range (700-3400 pixels), width range (490-3600 pixels). * poster-anterior view(pa-view) of chest x-ray exclusion criteria: * the chest x-ray contains items that affect interpretation, such as chest tubes, endotracheal tubes, and heart rhythm regulators, but does not include patches and circuits used in electrocardiograms. * the chest x-ray that are difficult to interpret due to poor image quality.

Keywords: artificial intelligence
determining individualized cancer therapy in pancreatic cancer

Conditions: Pancreatic Neoplasms

Summary: this is a non-therapeutic exploratory observational precision oncology study designed to collect and analyze data that demonstrate the clinical efficacy and tolerability of personalized treatments based on molecular tumor profiling assessments (i.e., matched therapy) in adult pancreatic cancer patients. patient medical records, obtained both retrospectively and prospectively, will be examined for results of molecular profiling obtained through standard of care testing to help understand how well molecular testing might predicts response to therapy. patient demographic and outcome parameters to be evaluated include, but are not limited to, tumor response, time to treatment failure, patient survival, and toxicity.


Eligibility criteria:
inclusion criteria: * age ≥18 years. * pathologically confirmed pancreatic cancer. * ability to understand a written informed consent document and the willingness to sign it exclusion criteria: * age \<18 years. * primary cancer diagnosis other than pancreatic cancer.

Keywords: mutation genomics targeted therapy cancer pancreas
the effect of mta and prf application in periapical lesions

Conditions: Apical Periodontitis; Wound Heal

Summary: a total of 40 periapical lesions from the 33 patient undergoing apical surgery were randomly selected from december 2016-november 2017. patients were informed about the surgical procedure and signed a consent form. groups were divided in to 4; as control, mta (mineral trioxide aggregate), prf (platelet rich fibrin) and mta+prf groups. apical resection was performed in all groups. no other interventions were made to the control group. routine radiographs were taken in the 1st. 3th and 6th months. in the (approximately) 12th month of the procedures computerized tomography scans were taken. primary healing of the periapical tissues were evaluated and the outcomes were measured. patients have still been under control for the long term outcomes of the study.

44 apically infected periapical lesions were decided to enroll to the study from december 2016-november 2017. however; a total of 40 periapical lesions undergoing apical surgery were recruited for the planned clinical trial in the end. the study was conducted under randomized controlled protocol. patients were informed about the surgical procedures and signed a consent form. the anticipated outcomes, possible risks and benefits of the study as well as the alternative treatment options were explained to the patients. groups were designed to have 10 patients in each and randomly divided into four as; control, mta, prf and mta+prf. apical resection was performed in all groups. no other interventions were made to the control group. routine radiographs were taken in the 1st. 3th and 6th months. in the 12th month of the procedures computerized tomography (ct) scans were taken. primary healing of the periapical tissues were evaluated according to the volumes and the densities of the lesions. outcomes were measured. comparison between the initial and the last 3d ct scan volumes were made by medical image processing software (mimics, belgium). patients have still been under control for the long term outcomes of the study.

Eligibility criteria:
inclusion criteria: * single rooted canals * failed previous root canal treatment * retreatment at least 1 year previously * previous surgery with unresolved bony lesion exclusion criteria: * more than single rooted canals * chronic generalized periodontitis * any systemic disease contraindicating oral surgical procedures * evidence of root fracture * resorptive processes involving more than apical third of the root
force (falls, fracture, and osteoporosis risk control evaluation) study

Conditions: Osteoporosis

Summary: falls and osteoporosis-related fractures cause substantial morbidity and mortality in the elderly, and are an increasingly important public health concern. a comprehensive multidisciplinary and integrated community-based approach is needed to identify and manage the population at highest risk of these complications. unfortunately, current gaps in continuity of care and health intervention result in a sub-optimal state of health service for these individuals. the falls, fracture and osteoporosis risk control and evaluation (force) study is a two-year randomized controlled trial evaluated on the effect of coordinated community-based, multidisciplinary approach for fall and fracture prevention in sault ste. marie.

the force partners are a broad collaboration of interested consumers, stakeholders and providers, led by the algoma health unit (ahu) and the group health centre (ghc) - a community-based, not-for-profit, multidisciplinary health organization. other partners include the multi-agency, consumer-orientated algoma district slips, trips and falls committee, the sault area hospital (sah), the algoma community care access centre (accac), and pharma companies alliance (aventis and proctor \& gamble), merck frosst and lilly. the green shield foundation has also provided sponsorship.the results of this study might directly benefit up to eight thousand seniors in the district by providing the impetus to integrated, evidence-based health services. qualitative and quantitative research during this time will also be a unique opportunity to identify the modifiable barriers to the continuity and quality of care in this high-risk population. by involving the community, the project will also educate those at future risk and hopefully prevent disease and complications. evaluation and research should provide nationally suggestions for better health service delivery.

Eligibility criteria:
inclusion criteria: * 55 years of age or older * independent living within the city of sault ste. marie, ontario, canada * capable of providing informed consent exclusion criteria: * not at risk for falls * unable to give informed consent
efficacy and safety of a new compression system urgo bd001 in the treatment of vlu (freedom)

Conditions: Venous Leg Ulcer

Summary: the aim of this study is to evaluate the therapeutic efficacy and the safety of the new compression system urgo bd001 in the management of venous or mixed predominantly venous leg ulcers. the therapeutic efficacy will be the reduction in wound surface area during a six weeks study treatment period.

the compression bandage urgo bd001 is indicated for the management of venous leg ulcers with abpi (ankle brachial pressure index) ≥ 0.8, venous oedema and lymphedema justifying strong compression. the pressure applied with the compression system urgo bd001 help to improve venous return and to reduce venous oedema. the expected clinical benefits from the compression system urgo bd001 in patient with a vlu are to increase healing rate and time to healing, and to improve patient quality of life.

Eligibility criteria:
inclusion criteria: * patient affected by vlu or mixed ulcer of predominantly venous origin (ankle brachial pressure index (abpi) ≥ 0.8 and ≤ 1.3), * wound in granulation phase (granulation tissue ≥50%), * wound at least 3 cm away from any edge of another wound, * vlu between 2 and 20 cm2 in surface area, * vlu duration between 1 to 24 months. exclusion criteria: * patient under guardianship or protection of vulnerable adult, * patient with known allergy to any components of the tested compression system, * patient with a severe illness that might lead to premature discontinuation of the trial before the end of treatment period, * patient with progressive neoplastic lesions treated by radiotherapy, chemotherapy, hormone therapy or immune suppressor, * patient with non-controlled systemic infection by a suitable antibiotic therapy, * patient who had a deep vein thrombosis within 3 months prior to the inclusion, * patient with a lymphedema due to lymphatic obstruction, * diabetic patient with advanced diagnosed microangiopathy, * bedridden patient, or those spending less than one hour per day on their feet, * wound covered partially or totally with necrotic tissue, * clinically infected wound, * wound requiring surgical treatment or for which a surgery is scheduled during the study period, * cancerous lesions.
impacts of application of virtual reality on gait and balance for stroke patients

Conditions: Stroke

Summary: the goal of this clinical trial is to learn about effects of virtual reality combined with conventional therapy on the balance, gait, and quality of life in stroke patients in the subacute and chronic stages. the main questions it aims to answer are: • virtual reality combined conventional therapy interventions can improve the gait, balance and functional status of stroke patients or not? participants will asked to do about 3 tasks in virtual reality intervention * walk in the flat ground * cross the obstacle on the ground * cross to moving obstacles

the investigators referred to the scenes designed by previous studies to develop the three virtual environments employed in this study and made slight modifications according to taiwan's conditions. google earth virtual reality (google inc., mountain view, california, u.s., 2017) was uesd for the first and second task and street champ virtual reality (zynk software srl , cluj, romania, 2016) was used for the third task. time constraints, terrain changes, and moving obstacles were set to increase the difficulty of the walking task. the speed obtained by the 10-m walking pretest was used as the training benchmark. the participants had to complete a task three times to proceed to the next level. for patient registries: on-site audit.the subjects were referred from the rehabilitation clinic of kaohsiung municipal ta-tung hospital

Eligibility criteria:
inclusion criteria: * 1. clinical diagnosis of stroke. 2. must be able to ambulation with or without devices. 3. were able to communicate and follow instructions. 4. were rehabilitated at kaohsiung municipal ta-tung hospital. exclusion criteria: * 1. limb apraxia. 2. any vision impairments. 3. any hearing impairments. 4. any vestibular impairments. 5. any comorbidities that affected movements.

Keywords: stroke balance virtual reality walking pace gait
the role of postoperative antibiotics in laparoscopic cholecystectomy

Conditions: Infection Wound; Antibiotic Resistant Infection

Summary: comparison between postoperative parenteral prophylactic antibiotics, and oral antibiotics regarding the incidence of post laparoscopic cholecystectomy infection.


Eligibility criteria:
inclusion criteria: * adult patients (aged above 18 years) undergoing laparoscopic cholecystectomy. exclusion criteria: * patients with comorbidities (diabetes, malignancies, immunosuppressed). lost of follow-up. patients received antibiotics within 72 hr before admission. complicated cases involved, gangrenous and perforated cholecystitis and abscess.

Keywords: antibiotic prophylaxis cholecystectomy postoperative
cardiovascular risk stratification in covid-19

Conditions: Covid19; Cardiovascular Risk Factor

Summary: this retrospective double-cohort study seeks to: 1. describe the cardiovascular manifestations and electrophysiological (ep) substrate in covid-19 infection and their association with clinical outcomes; and 2. develop a method of cardiovascular risk stratification in covid-19


Eligibility criteria:
inclusion criteria: * age \>=18y * available data on covid19 test in the electronic medical record (either positive or negative) exclusion criteria: * no data of covid19 test

Keywords: covid19 cardiovascular risk factor electrocardiogram risk stratification
ultrasound b mode imaging and elastography

Conditions: Dupuytren's Contractures

Summary: a pilot study on ultrasound b mode imaging and elastography during administration of xiaflex (collagenase clostridium histolyticum) for dupuytren's contracture.

ultrasound analysis will be obtained on patient that receives xiaflex as standard of care for dupuytren's contracture

Eligibility criteria:
inclusion criteria: * normal hand or hand dupuytren's contracture exclusion criteria: * previous treatment of dupuytren's cord
bladder catheterization after mini-pcnl

Conditions: Urolithiasis

Summary: 60 patients inclusion criteria: * age from 18 to 70 years * indications for mini-pcnl * asa score: 1-3 * single percutaneous access to pyelocaliceal system * size of solitary calculus up to 2.5 cm exclusion criteria: * active urinary tract infection * coagulopathy * clinically significant infravesical obstruction (qmax less than 10 ml / s, pvr more than 50 ml)

60 patients after pcnl will be recruited and randomized into 2 groups (30 vs 30): * no catheterization after mini-pcnl (study) - the bladder catheterization is not performed. * catheterization after mini-pcnl (control) - the bladder will be drained with the urethral catheter. all patients will fill out the vasp in 2, 6, 12, 24 hours after mini-pcnl. ultrasound examination of urinary bladder will be performed after mini-pcnl. all the ae will be registered.

Eligibility criteria:
inclusion criteria: * 18 to 70 years * indications for mini-pcnl * asa score: 1-3 * single percutaneous access to pyelocaliceal system * size of solitary stone up to 2.5 cm exclusion criteria: * active urinary tract infection * coagulopathy * clinically significant infravesical obstruction (qmax less than 10 ml / s, pvr more than 50 ml)

Keywords: urolithiasis pcnl bladder catheterisation