algorithmic-based evaluation and treatment approach for robotic gait training

Conditions: Complete Spinal Cord Injury; Incomplete Spinal Cord Injury; Acquired Brain Injury; Multiple Sclerosis

Summary: the purpose of this study is to develop an algorithmic-based evaluation and treatment approach for wearable robotic exoskeleton (wre) gait training for patients with neurological conditions.


Eligibility criteria:
spinal cord injury inclusion criteria: * male or non-pregnant female * ≥18 years of age * chronic (\> 6 mo post) injury * diagnosis of spinal cord injury * able to achieve adequate fit within exoskeleton * sufficient range of motion to attain normal, reciprocal gait pattern, and transition from normal sit to stand or stand to sit * weight \<220 pounds * intact skin on all surfaces in contact with device and load bearing surfaces * ability to perform informed consent * cognitively intact and able to follow directions and demonstrate learning capability spinal cord injury exclusion criteria: * pregnancy * spinal instability * non-english speaking * unhealed limb or pelvic fractures or any condition restricting weight bearing in limbs * diagnosis of other neurological injury other than sci such as cva, ms, abi, cp * uncontrolled spasticity (≥3 on modified ashworth scale)\[21\] * colostomy * decreased range of motion or contractures in legs (\>10° at hips, knees or ankles) * uncontrolled autonomic dysreflexia * unresolved deep vein thrombosis * inability to tolerate standing due to cardiovascular issues or orthostatic hypotension * severe comorbidities: active infections, heart, lung, or circulatory conditions * pressure sores, impaired skin integrity acquired brain injury(abi) inclusion criteria: * male or non-pregnant female * ≥18 years of age * chronic (\> 6 mo post) injury * able to achieve adequate fit within exoskeleton * ability to perform informed consent * sufficient range of motion to attain normal, reciprocal gait pattern, and transition from normal sit to stand or stand to sit * weight \<220 pounds * intact skin on all surfaces in contact with device and load bearing surfaces * cognitively intact and able to follow directions and demonstrate learning capability acquired brain injury(abi) exclusion criteria: * pregnancy * spinal instability * non-english speaking * unhealed limb or pelvic fractures or any condition restricting weight bearing in limbs * diagnosis of other neurological injury other than abi such as sci, ms, tbi, cp * decreased range of motion or contractures in legs (\>10° at hips, knees or ankles) * inability to tolerate standing due to cardiovascular issues or orthostatic hypotension * pressure sores, impaired skin integrity * uncontrolled spasticity (≥3 on modified ashworth scale) * colostomy * severe comorbidities: active infections, heart, lung, or circulatory conditions * unresolved deep vein thrombosis multiple sclerosis (ms) inclusion criteria: * male or non-pregnant female * ≥18 years of age * chronic (\> 6 mo post) injury * diagnosis of multiple sclerosis * ability to perform informed consent * sufficient range of motion to attain normal, reciprocal gait pattern, and transition from normal sit to stand or stand to sit * weight \<220 pounds * able to achieve adequate fit within exoskeleton * intact skin on all surfaces in contact with device and load bearing surfaces * cognitively intact and able to follow directions and demonstrate learning capability multiple sclerosis (ms) exclusion criteria: * pregnancy * spinal instability * non-english speaking * unhealed limb or pelvic fractures or any condition restricting weight bearing in limbs * decreased range of motion or contractures in legs (\>10° at hips, knees or ankles) * inability to tolerate standing due to cardiovascular issues or orthostatic hypotension * uncontrolled autonomic dysreflexia * unresolved deep vein thrombosis * pressure sores, impaired skin integrity * uncontrolled spasticity (≥3 on modified ashworth scale) * colostomy * severe comorbidities: active infections, heart, lung, or circulatory conditions\[23,24\] * diagnosis of other neurological injury other than ms such as cva, sci, abi, cp * ms relapse in 3 months prior to recruitment able bodied inclusion criteria: * male or non-pregnant female * ≥18 years of age * weight \<220 pounds * cognitively intact and able to follow directions and demonstrate learning capability\[23\] * healthy individuals with no history or diagnosis of neurological injury * sufficient range of motion to attain normal, reciprocal gait pattern, and transition from normal sit to stand or stand to sit * able to achieve adequate fit within exoskeleton * intact skin on all surfaces in contact with device and load bearing surfaces * ability to perform informed consent\[24\] able bodied exclusion criteria: * pregnancy * spinal instability * non-english speaking * unhealed limb or pelvic fractures or any condition restricting weight bearing in limbs * diagnosis of neurological injury such as cva, sci, abi, cp, ms * decreased range of motion or contractures in legs (\>10° at hips, knees or ankles) * severe comorbidities: active infections, heart, lung, or circulatory conditions * colostomy