Kornimate/medical-research-clean huggingface dataset:
immunogenicity of the chadox1 n cov-19 vaccine with 12-dose vial

Conditions: Covid19; Vaccine; Immunogenicity

Summary: chad0x1 ncov-19 (azd 1222) is the main vaccine that is planned to roll-out in thailand and involve vaccinating people especially in high-risk categories. this vaccine is contained in the multiple-dose vial for vaccinating 10 recipients for 0.5 ml each. however, the additional volume of vaccine was overfilled to 6.5 ml per vial which the vaccination can be administered to more than 10 doses. the university hospital network (uhosnet) and faculty of medicine vajira hospital, navamindradhiraj university have jointly stipulated the preparation and vaccination of chadox1 - n cov-19 vaccine with 12 doses per vial injection with traditional 21 or 24 g needle. taken together, the investigators planned to investigate the immune response of participants after first dose of chad0x1 ncov-19 vaccination with such technique

the investigators measured anti-sars-cov-2 antispike rbd igg and neutralizing antibody by surrogate virus neutralizing test (svnt) in adults between age 18-72 year after first dose of chad0x1 ncov-19 vaccine.the primary outcome was the antibody levels.the secondary outcome were adverse events,factors affecting antibody levels and incidence of covid-19 infection at the time of study

Eligibility criteria:
inclusion criteria: * participants were eligible if they were more than 18 years old. exclusion criteria: * allergic to components of vaccine * risk of covid-19 infection in the previous 14 days before enrollment i.e close contact with index cases or history of fever with upper respiratory tract infection.

Keywords: covid-19 immunogenicity neutralising antibody antispike rbd chad0x1 ncov-19
cross-sectional study of use of speckle method in early diagnosis of cardiovascular dysfunction

Conditions: Sjogren Syndrome

Summary: speckle tracking (ste) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (sr). it is demonstrated that these parameters provide important insights into systolic and diastolic function, ischaemia, myocardial mechanics and many other pathophysiological processes of the heart. in this preliminary study, we investigated the role of ste in detection of early ventricular dysfunction in patients with sjogren syndrome, focusing on cardiorespiratory fitness.


Eligibility criteria:
inclusion criteria: * diagnosis of sjogren syndrome exclusion criteria: * previous cardiovascular events * unstable angina * stroke * diagnosis of heart failure * incapacity to provide an informed consent
ibuprofen versus indomethacin following emergent cerclage placement

Conditions: Preterm Labor

Summary: cervical insufficiency is defined as painless cervical dilation in the second trimester. cervical insufficiency can ultimately lead to second trimester loss of pregnancy. cerclages are utilized in pregnancies affected by cervical insufficiency in order to prolong gestational latency. there have been several studies investigating the efficacy of perioperative medications for cerclage placement and the effects they have on gestational latency. some such studies have found that perioperative indomethacin in combination with antibiotics have significantly increased gestational latency when compared to placebo. indomethacin has traditionally been the tocolytic of choice with cerclage placement. at our hospital, ibuprofen has been the tocolytic of choice for cerclage placement secondary to pharmacy availability. our study aims to evaluate whether gestational latency differs among patients undergoing emergent cerclage whether they receive perioperative ibuprofen or indomethacin.


Eligibility criteria:
inclusion criteria: * viable, singleton pregnancy * ≥ 18 years old * gestational age 16 weeks 0/7 days - 23 week 6/7 days (inclusive) * intact membranes at time of enrollment * planning to deliver at woman's hospital * exam or ultrasound indicated cerclage placement exclusion criteria: * contraindication to treatments (i.e. ibuprofen or indomethacin) * unwilling to be randomized to treatment * prophylactic cerclage placement * temperature greater than 100.4 * known major fetal congenital anomaly * prior cerclage placement during the current pregnancy * recent (within 7 days) receipt of ibuprofen or indomethacin

Keywords: cerclage
sap versus esp block in multimodal pain management in mini-invasive thoracic surgery: an observational prospective multicentric study

Conditions: SAP Block Versus ESP Block; Pain, Postoperative; Evaluation of Locoregional Techniques; Multimodal Pain Management

Summary: thoracic surgery is characterized by acute perioperative pain. there are different ways to provide analgesia, such as intravenous analgesics (opioids or non-opioids) or loco-regional procedures; these techniques are often used together in the context of a multimodal approach to pain management, in order to exploit their synergistic action and minimize side effects. in this observational prospective multicentric study the investigators evaluate the effectiveness of two routinely administered ultrasound guided loco-regional analgesic techniques in providing analgesia to patients undergoing mini-invasive lung-resective thoracic surgery. the two techniques compared are the serratus anterior plane (sap) block and the erector spinae plane (esp) block.

whatever the loco-regional technique is (sap block or esp block), it must have been administered in the immediate preoperative phase; both procedures are routinely used for analgesic purpose in the clinical practice of the three centers involved in the study and are performed under ultrasound guide. using medical records, data collected by acute pain service nurses and patients' interviews useful data will be collected: demographic and clinical characteristics (age, sex, weight, comorbidities), surgical data (type of procedure, surgical approach and duration of surgery) and anesthesia data (type of block, dose and type of local anesthetic with record of potential side effects), intraoperative and postoperative opioid and non-opioid analgesic consumption (and rescue if needed) with record of potential side effects, pain evaluation in the first 24 hours after surgery and after at 3 months.

Eligibility criteria:
inclusion criteria: * lung-resective thoracic surgery (lobectomy, bilobectomy, segmentectomy and wedge resection) with videothoracoscopic or mini-thoracotomic approach (maximum duration 180 minutes) * bmi ranging from 18 to 30 * age \> 18 years * asa i-iii * ultrasound guided preoperative esp block or sap block * remifentanil as intraoperative opioid exclusion criteria: * patient's refusal * weight \< 50 kg * pregnancy * emergent surgery * chronic opioid therapy * history of drug or benzodiazepine addiction or alcohol abuse * previous thoracic surgery

Keywords: sap block esp block pain management mini-invasive thoracic surgery sap esp locoregional multimodal
the implantation under echography of fiducial markers in the intraprostatic lesion and prostate

Conditions: Prostate Cancer

Summary: implantation of fiducial markers in the prostate and daily check of the positioning during radiotherapy based on the implanted fiducial markers


Eligibility criteria:
inclusion criteria: * histological proven adenocarcinoma of the prostate * t1-t4 tumors * radiotherapy as primary therapy +/- androgen deprivation * presence of an intraprostatic lesion (ipl) on mri/mrs * presence of an intraprostatic lesion (ipl) on ultrasound * who 0-2 exclusion criteria: * other primary tumor, except non-melanoma skin cancer * no written informed consent
gastroparesis as an early sign of sepsis

Conditions: Gastroparesis and Sepsis

Summary: upper gastrointestinal tract disorders, such as gastroparesis, are common in critically ill patients in the icu, estimated at 60%. gastroparesis symptoms include nausea, vomiting and abdominal pain. risk factors for the development of gastroparesis include diabetes, surgical injury to the vagus nerve (such as certain types of bariatric surgery, and in the past - surgeries for patients who suffered from peptic ulcer), use of drugs that inhibit the activity of the digestive system such as opiates, anticholinergic drugs, sepsis, as well as being bedridden and inactive - are all common conditions in critically ill patients. there are different definitions for gastroparesis. one of the accepted definitions refers to gastric residual volume (grv) over 200 ml at one measurement. gastroparesis is found in some studies to be associated with increased morbidity and mortality in critically ill patients. as mentioned above, it is known that sepsis is a risk factor for gastroparesis. according to our experience based on treatment of a large number of septic patients, we have the impression that often gastroparesis is an early sign for the development of sepsis. we did not find any studies that tested this hypothesis. in this study we would like to investigate whether the development of gastroparesis in critical patients in intensive care can be a predictive sign for the development of sepsis.


Eligibility criteria:
inclusion criteria: patients aged 18--99 who were admitted to the general intensive care unit from january 2015 to april 2021, and who were diagnosed with acquired bacteremia in the icu (positive blood culture after 48 hours or more from icu admission). as a control group we will collect data regarding a similar number of patients who were admitted during this time period but were not diagnosed with acquired bacteremia or sepsis during their stay in the unit. - exclusion criteria: patients who did not meet the above criteria or for whom data were missing. likewise, patients who did not have a nasogastric tube will be excluded (we cannot test gastirc residual volume) as well as patients who were admitted after abdominal surgery (gastroparesis is a common finding in these patients regardless of sepsis and may be a confounder. in addition, acquired bacteremia in these patients could be the result of a surgical complication, such as intra-abdominal sepsis secondary to intestinal leak etc., and gastroparesis usually accompanies abdominal sepsis and will not be the result of sepsis per-se). -
creating satisfying engagement in daily life through coaching for people with multiple sclerosis

Conditions: Multiple Sclerosis; Quality of Life

Summary: multiple sclerosis (ms) is a complex disease that negatively impacts a person's ability to participate in a wide range of important and meaningful activities1-4. ms rehabilitation interventions often focus on reducing symptoms, with the assumption that fewer symptoms will lead to improved participation in daily activities5-8. yet, literature shows that engagement in necessary and desired activities requires more than symptom reduction - it requires people with chronic diseases like ms to apply their knowledge and skills to a complex self-management process9-11 that balances personal values, and activity and environmental demands. core self-management skills include self-monitoring, problem-solving, decision-making, goal setting, action planning, and the ability to adjust plans when necessary12. looking beyond ms, coaching interventions have enabled people with stroke13-16, traumatic brain injury17, and parkinson's disease18, 19 to develop self-management skills and achieve personally meaningful activity goals. occupational performance coaching (opc) is a well-developed form of coaching that builds competence in core self-management skills and improves participation in daily activities20, 21. the investigator's preliminary work indicates that opc is an acceptable and feasible intervention for people with ms22. the investigators now must determine if opc reduces the impact of ms on participation in daily activities and increases the satisfaction of people with ms in performance of personally important daily activities. therefore, the investigators will conduct a waitlist-control randomized clinical trial (rct) with 30 adults with ms to determine if receipt of six opc sessions improves participants' satisfaction with performance in daily activities (primary outcome). the investigators will also examine whether opc reduces illness intrusiveness (ms impact), improves resilience, and improves autonomy and participation (secondary outcomes).


Eligibility criteria:
inclusion criteria: * able to participate in coaching in english. exclusion criteria: 1. serious cognitive impairment as indicated by a score of 10 or more on the short blessed test, 2. severe depression as measured by the phq-2 3. are receiving life, health or executive coaching by a certified coach

Keywords: coaching
efficacy of ezetimibe/simvastatin 10/20 mg and mk0524a (1-2 g/day) in mixed hyperlipidemia and two or more risk factors

Conditions: Cardiovascular Diseases; Hyperlipidemia

Summary: to measure the percentage of patients who achieve all the treatment lipid goals being treated with ezetimibe/simvastatin 10/20 with or without mk0524a (1-2 g/day).

patients will receive placebo for 4 weeks, then vytorin 10/20 mg for 6 weeks, if efficacy of treatment is achieved, they will continue with vytorin 10/20 mg + placebo for 12 more weeks, if not achieved, will receive vytorin 10/20 mg + mk0524a 1 gr for 6 weeks, if efficacy achieved will continue with vytorin 10/20 mg + mk0524a 1 gr + placebo; if not achieved, will receive vytorin 10/20 mg + mk0524a 2 gr for 6 weeks.

Eligibility criteria:
inclusion criteria: * patient without ischemic cardiovascular disease who during the treatment with statin have ldl-c \<130 mg/dl at visit 1 or within the 6 month period before visit 1 exclusion criteria: * the use of any other lipid lowering agent * life expectancy lower than a year. * any condition that may interfere with the adherence to the study protocol
efficacy of the mobile application for prediction and prevention of mood episode recurrence based on machine learning

Conditions: Major Depressive Disorder; Bipolar 1 Disorder; Bipolar II Disorder

Summary: this study was designed to evaluate the efficacy of the mobile application named circadian rhythm for mood (crm), which was developed to prevent recurring episodes of mood disorders (major depressive disorders, bipolar disorders type 1 and 2) based on machine learning.


Eligibility criteria:
inclusion criteria: * male and female patients, 19-70 years old * diagnosis with bipolar i disorder, bipolar ii disorder, major depressive disorder based on dsm-5 criteria, in euthymic state for more than two weeks at the time of the recruitment * android smartphone users, capable of installing and executing the crm application * consent to wear wearable device (fitbit) continuously and synchronize and backup data regularly exclusion criteria: * patients who have not experienced major depressive, manic, or hypomanic episode in the last two years * patients who are difficult to specify mood episode or evaluate symptoms of mood episode independently due to personality traits (borderline personality trait, cyclothymic temperament, etc.) * patients with degenerative neurological disorders (parkinson's disease, dementia, huntington's disease, etc.), neurodevelopmental disorders (intellectual disorder, autism spectrum disorder, down syndrome, etc.), epilepsy, severe traumatic brain damage, stroke, and other brain neurological disorders * inmates or patients who are forced into custody for the treatment of mental or physical illness (non-voluntary isolation or hospitalization) * patients with difficulties in understanding the objectives and process of the study and the potential benefits and risks of participating in the study
family navigator intervention

Conditions: Treatment as Usual; Family Navigator

Summary: this study will develop and examine the feasibility and acceptability of a family navigator protocol while leveraging digital health communication. it will employ an ecological model within a socio-cultural theoretic framework of mental health service disparities and barriers to treatment.

the purpose of this study is to develop and pilot a family navigator intervention with technology-enhanced information sharing for families with youth (80 youth-caregiver dyads) who were discharged from the emergency after an admission for ssib. this novel intervention aims to reduce suicidal and non-suicidal self-injurious behavior risk and prevalence rates by way of increasing attendance to community-based mental health services for youth aged 10 to 14.

Eligibility criteria:
inclusion criteria: * youth 10 to 14 years old living at home with legal guardian/caregiver exclusion criteria: * presentation including psychosis, sexual assault, or child abuse, * are in police or child protective services' custody, * are unable to assent due to severity of illness or developmental disabilities, \>cannot communicate in english or spanish, or * if no caregiver or legal guardian is able to provide consent.

Keywords: emergency department, suicide, youth, family navigator
compensatory and restorative rehabilitation techniques in stroke

Conditions: Cognitive Impairment

Summary: the aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke.

stroke is a prevalent medical neurological condition that often results in cognitive impairments, particularly in the domain of executive functions. cognitive impairment has a significant impact on executive function in stroke subjects. cognitive impairment on the stroke survivor exist on any single domain such as attention, spatial ability, language and executive ability more frequently than the multiple domains. cognitive training has been shown to be beneficial for rehabilitation of patients with cognitive impairment, but the underlying mechanisms remain unclear. the combination of restorative and compensatory rehabilitation techniques is beneficial for gaining control over cognitive rehabilitation techniques will improve executive functions. the retention effects evaluated additionally will add a broad insight in this regard. it will improve the learning power of brain through neural plasticity. this leads to restoration of everyday functioning. this study aims to investigate the effects of two distinct rehabilitation approaches on the executive functions of stroke survivors with mci. understanding how these rehabilitation strategies impact cognitive recovery is essential for individuals living with post-stroke cognitive impairments.

Eligibility criteria:
inclusion criteria: * age between 50 and 70 years * both genders * individuals diagnosed with stroke 6 months before enrollment * minimum 6 years of schooling * patients with mild cognitive impairment (score 18-25 on moca) * individuals able to maintain sitting and standing balance (score 41 on berg balance scale) exclusion criteria: * \>10 on post stroke depression rating scale (psdrs) * spasticity (\>3 on ashworth scale) * other psychological disorders * patients diagnosed with alzheimer's and dementia

Keywords: compensatory rehabilitation restorative rehabilitation cognition stroke executive functioning
efficacy and visual quality of orthokeratology lenses with different designs

Conditions: Myopia; Myopia; Refractive Error

Summary: orthokeratology (ortho-k) lens is very effective in slowing down axial elongation in myopic children by 30% to 63% when compared to children wearing single-vision spectacles or contact lenses. more recently, it is reported that the children wearing orthok lens of smaller back optical zone diameter (bozd) demonstrated a smaller axial elongation when compared to children wearing lens with larger bozd. we aimed to explored the myopia efficacy and visual quality of ortho-k with different bozd (5.0mm or 6.2mm).

this prospective study aimed to evaluate the efficacy of orthokeratology lenses with different back optical zone diameters (bozd) in slowing axial elongation. additionally, visual quality will be assessed through measurements of wavefront aberrations, contrast sensitivity, and subjective visual quality using a validated questionnaire. the study seeks to explore the effectiveness of various ortho-k lens designs and the potential factors influencing their outcomes.

Eligibility criteria:
inclusion criteria: * age between 8 and 13 years. * subjective refraction under cycloplegia: spherical power between -4.00 d and * 1.00 d, with cylindrical power≤ 1.50 d. * best-corrected visual acuity (bcva) of ≥ 1.0 based on subjective refraction. * willing to participate in the clinical trial and provide signed informed consent. exclusion criteria: * one eye met the inclusion criteria * patients with systemic diseases causing immunocompromised or affecting orthokeratology * there are other eye diseases that affect orthokeratology lens wearing, such as dacryocystitis, blepharitis, various inflammation, glaucoma, etc * abnormal cornea * previous corneal surgery or corneal trauma history * active keratitis (e.g., corneal infection) * patients with best corrected distance visual acuity of less than 5.0 * patients with corneal flat curvature lower than 39.00d, or higher than 48.00d * patients with refractive instability * patients with overt strabismus * the corneal epithelium showed obvious fluorescent staining, which was not suitable for patients wearing orthokeratology lenses * patients with dry eye are not suitable for orthokeratology * patients with corneal endothelial cell density less than 2000 cells /mm2 * patients who had worn rigid contact lenses (including orthokeratology lenses) within the previous 30 days
pancreatic cancer: dynamic assessment at all stages of treatment

Conditions: Pancreatic Cancer Non-resectable

Summary: the study consists of a 25 ml blood sample collection: * before the start of treatment * approximately 2 months after the start of induction chemotherapy * at the end of induction chemotherapy * prior to local treatment (radiotherapy, surgery) * at the time of tumor progression collection of tumor material: * during the initial diagnostic biopsy * on the operating room in case of surgery * at tumor biopsy in case of recurrence or progression (optional) as well as the completion of a questionnaire at inclusion.


Eligibility criteria:
inclusion criteria: * non-metastatic pancreatic adenocarcinoma that is not immediately resectable (borderline and locally advanced tumors according to the nccn 2020 classification) * no previous treatment with surgery or chemotherapy * age \> 18 years * general condition who 0-2 (patient whose general condition can allow medical treatment or surgery) * therapeutic management at the paoli-calmettes institute * signature of the informed consent specific to the pandore-panc study * patient affiliated to a social security system or benefiting from such a system exclusion criteria: * metastatic disease * pancreatic tumor of a histological type other than adenocarcinoma * other tumor under treatment or for which treatments have been completed for \< 1 year * pregnant or breastfeeding women * person in an emergency situation * person of legal age under legal protection (guardianship, curatorship or safeguard of justice) or unable to give consent.