Kornimate/medical-research-clean huggingface dataset:
research of circulating tumor cells released during endometrial cancer surgery.

Conditions: Endometrial Cancer

Summary: the purpose of this study is to investigate the spread of circulating tumor cells (ctc) during surgery in endometrial cancer. although this cancer is often discovered at early stage, the risk of recurrence is estimated at 6 to 21%, according to grade. early stage tumor is accessible for curative surgical treatment by laparoscopy but this kind of surgery may induce ctcs spread, and could be an explanation of this recurrence. through this study, concordance between two blood punction sites, peripheral vein and ovarian vein, will be evaluated to detect these cells during surgery.

the goal of this single-center clinical trial is to determine the best blood punction site to observe the spreading of ctc during surgery in endometrial cancer. ctcs are very rare events on blood and their detection require extremely sensitive technologies. this pilot study will investigate ctc spread during surgery on 10 patients with endometrial cancer. the main objective is to compare venipuncture site for detection of ctcs in endometrial cancer during surgery. blood samples are collected on a simple sampling (arm) compared to sampling as close as possible to the tumor (ovarian vein).

Eligibility criteria:
inclusion criteria: * patients with endometrial cancer * being affiliated or benefiting from a french social security system exclusion criteria: * patients with an other cancer

Keywords: endometrial cancer circulating tumor cells laparoscopy
exercise and life modification for text-neck

Conditions: Pain; Exercise; Posture

Summary: objectives: the purpose of the study was to investigate the effects of exercise and life modification on pain and disability in "text neck". methods: eighty-five participants were randomly divided into three groups: exercise (n=29), exercise+life modification (n=28), and control group (n = 28). pain intensity during rest, activity, and at night was evaluated with visual analogue scale (vas) and functional assessment was done by using neck disability index at the beginning and at the end of 4 weeks.

objectives: smartphones or tablets have made an important place in our lives. however long-term use of technological tools causes postural disorders and neck pain called "text neck". the purpose of the study was to investigate the effects of exercise and life modification on pain and disability in "text neck". methods: eighty-five participants with "text-neck" were randomly divided into three groups: exercise (n=29), exercise+life modification (n=28), and control group (n = 28). first group received a home exercise program treatment for 4 weeks. second group received life modification suggestions additional to home exercise treatment program. control group did not receive any treatments. pain intensity during rest, activity, and at night was evaluated with visual analogue scale (vas) and functional assessment was done by using neck disability index at the beginning and at the end of 4 weeks.

Eligibility criteria:
inclusion criteria: * participants who were aged between 18 and 30, using technological devices as tablets and smartphones for more than 5 hours and having neck pain for more than 3 months were included in our study. exclusion criteria: * the exclusion criteria included those: 1. who had any diagnosed pathology for neck region diagnosed by mr or bt, 2. who had any shoulder pathology, 3. with any neck or shoulder surgery, 4. had whiplash syndrome, 5. had fibromyalgia, myofasial pain syndrome or vascular pathology and 6. women who are breastfeeding.
non-invasive assessment of arterial blood pressure and functional hemodynamic parameters

Conditions: Surgical Procedure, Unspecified

Summary: cardiac output can be monitored using different invasive devices. nexfin hd is a new, noninvasive device that uses model flow technology to measure stroke volume and thus computes cardiac output (co). to evaluate this new device the investigators compared esophageal doppler co to nexfin hd co in patients scheduled for elective abdominal surgery.


Eligibility criteria:
inclusion criteria: * age \> 18 and \< 80 years old * written informed consent obtained exclusion criteria: * renal failure * heart failure (ef \< 25%) * peripheral artery occlusion disease * m. raynaud * rhythms other than sinus

Keywords: stroke volume cardiac output validation
comparison of the effect of prewarming on intraoperative hypothermia in patients undergoing holmium laser prostatectomy

Conditions: Prewarming; Holmium Laser Prostate Surgery; Hypothermia Following Anesthesia

Summary: this study aims to evaluate the effectiveness of prewarming methods in preventing intraoperative hypothermia in patients undergoing holep surgery. designed as a randomized controlled study, patients who receive prewarming will be compared with those in the control group.


Eligibility criteria:
inclusion criteria: * male patients aged 18 years and older * patients undergoing holep surgery under general anesthesia * patients who consent to participate in the study exclusion criteria: * patients who refuse to participate in the study. * patients unable to read, understand, or sign the informed consent form. * hemodynamically unstable patients. * patients with a preoperative or intraoperative body temperature \>37°c.
migraine and infertility

Conditions: Migraine

Summary: the purpose of this study is to determine the prevalence of migraine in infertile women and during in vitro fertilization protocol. migraine is two to three times as common in women as in men. migraine has considerable impact on quality of life. in vitro fertilization has become a common therapeutic modality in modern fertility medicines. treatment protocols are associated with exaggerated hormonal fluctuations. estrogen is considered to be closely linked to migraine and its fluctuations have been considered to trigger migrainous headaches.

in vitro fertilization has become a common therapeutic modality in modern fertility medicines. treatment protocols are associated with exaggerated hormonal fluctuations. estrogen is considered to be closely linked to migraine and its fluctuations have been considered to trigger migrainous headaches. both migraine and infertility are associated with impaired quality of life. objectives: to assess the prevalence of migraine in infertile women and during in vitro fertilization protocol in order to improve the management of these patients. protocol: women coming to consult at the port royal infertility center and meeting the inclusion (infertile women without long-term analgesic treatment) criteria will be offered the study. the information note and no objection form will be given by the gynecologist receiving them for consultation. after collecting their non-opposition, a self-questionnaire will be given to them. this questionnaire is validated in the literature concerning the diagnosis of migraine. it includes questions about medical history and possible headaches. the patient fills it immediately and gives it to the investigator. as part of the usual management, and regardless of their answers to the questionnaire, some of the patients will be reviewed in consultation for the programming of an ivf. during this "incoming" consultation with one of the midwives of the unit, a schedule of migraine headaches will be given to the patients. they will keep it, will complete it in case of migraine, and will give it to the gynecologist during the embryo transfer or the doctor receiving the couple in consultation on day 7 in case of absence of embryo transfer.

Eligibility criteria:
inclusion criteria: * infertile women supported in reproductive medical assistance at the port royal infertility center * aged between 18 and 40 years old exclusion criteria: * long-term analgesic treatment * women under guardianship or curatorship

Keywords: migraine in vitro fertilization infertility
incidence and effects of sleep apnea on intracerebral aneurysms

Conditions: Sleep Apnea (Defined as Apnea Hypopnea Index > 5/h); Intracranial Aneurysm Size; Blood Pressure Medication; Comorbidities; Complications (Subarachnoid Hemorrhage)

Summary: patients with intracerebral aneurysm will be screened for sleep apnea using out of center polysomnography/polygraphy. baseline blood pressure and medication will be assessed. patients will be followed for up to 5 years to examine the increase in aneurysm size, rupture rate and changes in medication.

patient presenting to the outpatient center for neurological of neurosurgical management of intracerebral aneurysm will be recruited. sleep apnea will be assessed by questionnaire and out of center polygraph/polysomnography. medication, comorbidities and blood pressure will be recorded. change in aneurysm size and blood pressure medication will be evaluated annually for up to 5 years. frequency of subarachnoid hemorrhage and increase in aneurysm size will be assessed.

Eligibility criteria:
inclusion criteria: * intracerebral aneurysm * age \>= 18yrs. * ability to give informed consent exclusion criteria: * stroke within 3 month of study inclusion.

Keywords: sleep apnea, aneurysm, subarachnoid hemorrhage, blood pressure.
adjunctive lisdexamfetamine (ldx) in bipolar depression

Conditions: Bipolar; Depression

Summary: the specific aim of this study is to evaluate the efficacy and tolerability of lisdexamfetamine in the adjunctive treatment of bipolar disorder.


Eligibility criteria:
inclusion criteria: * subjects will meet dsm-iv-tr criteria bipolar i or ii disorder, exclusion criteria: * women who are pregnant, lactating, or of childbearing potential who are not using adequate contraceptive measures. * clinically unstable medical disease, including cardiovascular, hepatic, renal, gastrointestinal, pulmonary, metabolic, endocrine or other systemic disease. subjects should be biochemically euthyroid to enter the study.

Keywords: bipolar disorder manic depression depression bipolar i or ii
efficacy of cognitive restructuring and imagery modification to reduce the feeling of being contaminated after childhood sexual abuse

Conditions: Sexual Abuse; Posttraumatic Stress Disorder

Summary: the purpose of this study is to determine whether a short term programme with internet research on the frequency of skin exchange and guided imagery modification is effective in the treatment of the feeling of being contaminated in female victims of childhood sexual abuse (csa).

in the first session the women who suffer from a feeling of being contaminated after childhood sexual abuse are interviewed with the structured clinical interview for dsm-iv (scid) to ensure the clinical diagnosis of posttraumatic stress disorder and exclude women who meet the exclusion criteria. they get questionnaires and protocol sheets to fill out until the intervention session after a week. afterwards the women are randomly assigned to an intervention group or a waitlist control group. during the intervention session the women in the intervention group research via internet how many times their skin cells in different regions of their body have exchanged since the sexual abuse to get the information that their skin has changed hundreds and hundreds of times and has nothing in common with their skin in childhood or adolescence. this first part of the intervention is based on a component of the dbt-ptsd. afterwards the therapist guides an imagery modification. the women imagine the feeling of being contaminated and then to peel off their former contaminated skin and the maturing of hundreds of new clean skin cells to process the rational information of the internet research emotionally. at the end of the intervention session patients get a tape with the guided imagery instruction and commit to listen to the tape daily to exercise the guided imagery modification until the third session after a week. in the last session the homework is discussed and information on posttraumatic stress disorder and psychotherapeutic treatments of posttraumatic stress disorder is offered.women in the waitlist control group get the same treatment as the women in the intervention group after a period of five weeks.

Eligibility criteria:
inclusion criteria: * sexual abuse in childhood or adolescence * feeling of being contaminated * clinical diagnosis of posttraumatic stress disorder concerning the trauma of sexual abuse in childhood or adolescence according to dsm-iv * informed consent exclusion criteria: * currently in psychotherapy * life time clinical diagnosis of schizophrenia, schizoaffective disorder or bipolar disorder according to dsm-iv * body mass index \< 16,5 * endangerment of self or others * clinical diagnosis of alcohol or drug addiction according to dsm-iv * mental retardation

Keywords: childhood sexual abuse csa posttraumatic stress disorder ptsd, feeling of being polluted mental pollution, mental contamination feeling of being contaminated sexual assault disgust, shame
the relationship between the response to mental stress and vascular endothelial function

Conditions: Coronary Endothelial Dysfunction; Apical Ballooning Syndrome; Myocardial Infarction

Summary: the aim of this study is to measure how different people respond to mental stress. the investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects. in one part of the study the investigators will compare the cardiovascular responses to mental stress between healthy women and healthy men. in another part of the study, the investigators will compare the cardiovascular responses to mental stress between women with apical ballooning syndrome and healthy post-menopausal women. the investigators hypothesize that healthy men will have an increased vascular response to and decreased endothelial function in response to to mental stress, compared to health women. furthermore, the investigators hypothesize that women with apical ballooning syndrome will have an increased vascular response to and decreased endothelial function in response to mental stress.


Eligibility criteria:
inclusion criteria: * patients must be identified in one of the four groups outlined in "study population description." exclusion criteria: * other co-morbidities that would make the testing not possible. * women who have had a mastectomy and would not have an arm that could be occluded during the reactive hyperemia portion of the peripheral arterial tonometry testing.
genetic study of familial epilepsy

Conditions: Epilepsy

Summary: objectives: i. determine the chromosomal regions that contain genes that raise the risk of epilepsy in families by performing genetic linkage analysis of idiopathic/cryptogenic epilepsy.

protocol outline: family histories are obtained, then the patients undergo an interview, a neurological examination, and eeg. blood specimens are also collected. linkage analysis is performed on specimens and analysis of shared marker alleles are used to identify genomic regions likely or unlikely to contain the epilepsy genes. genotypes in family members are determined at microsatellite markers throughout the genome. markers tested include chromosomes linked to human epilepsy syndromes (6p, 8p, 8q, 20q, 21q) and chromosome 3 (similar to mouse "epilepsy" genes). linkage to markers on chromosome 10q are also tested. patients do not receive the results of the testing and the results do not influence the type and duration of any treatment.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- male or female members of families with at least 1 close relative pair (sibling, half sibling, avuncular, grandparent-grandchild, or first cousin) affected with idiopathic/cryptogenic epilepsy that developed before age 25

Keywords: epilepsy neurologic and psychiatric disorders rare disease seizures
the effect of an aerobic exercise programme in stroke patients

Conditions: Cerebrovascular Accident

Summary: this study aims to investigate the effect of aerobic exercise on the aerobic capacity, the daily functioning, post-stroke fatigue , depression and cardiovascular risk factors in stroke patients.

people with neurologic impairments after stroke often show decreased aerobic exercise capacity. the etiologies of which are assigned to physiologic changes in paretic muscle, gait deficits and disability-related deconditioning. this declares that stroke patients live an inactive lifestyle and therefore stay cardiovascular risk patients. the usefulness of aerobic training on aerobic capacity is recently been proved in clinical stroke research. however, no study can shown the long-term effect of aerobic exercises. also the effect of aerobic exercises on daily functioning, fatigue and depression in stroke needs to be established.

Eligibility criteria:
inclusion criteria: * first cva according to the who definition (a primary, first ever stroke ash revealed by rapidly developing clinical signs or focal or global disturbance or cerebral function, with symptoms lasting 24 hours or longer or leading to death, with no apparent cause other than or vascular origin.) this includes ischemic infarct or an intracerebral haemorrhage * the offense can be maximum 3 up to 6 weeks after onset * patient must be able to follow simple verbal instructions * to cycle during 1 minute at 20 watt, 50rpm, * cardiac stable exclusion criteria: * have another neurological impairments with permanent damage such as former cranial trauma, multiple sclerosis, epileptic status... which already present were for current cva * having on cva resembling symptoms as a result of subdural haemorrhage, a tumour, encephalitis or a trauma * barthel index \< 50 before the stroke onset * age \> 80 year * no authorisation form of the patient or of the family * absolute contra-indications for effort test (acc/aha guidelines)

Keywords: stroke aerobic exercise daily functioning rehabilitation
sputum validation for the molecular diagnosis of respiratory viral infections in cystic fibrosis

Conditions: Cystic Fibrosis; Respiratory Infection

Summary: the aim of this pilot study is to demonstrate the feasibility of viral biomolecular diagnosis in sputum compared to nasopharyngeal swab in cystic fibrosis acute respiratory infection.

in cystic fibrosis (cf), patients face polymicrobial airway infections. besides bacteria, viruses are now also considered as important agents in lung function deterioration. no strategy has been established on the optimal sampling for respiratory viral molecular diagnostic in cf. nasopharyngeal swabs (np) are recommended for respiratory viral screening in non-cf patients but are invasive and sometimes painful for patients. as sputa are non invasive and collected for bacterial monitoring in cf patients they could represent a convenient alternative to np swabs. this study's aim is to define whether viral screening give concordant results between sputa and np swabs.

Eligibility criteria:
inclusion criteria: * participant with cystic fibrosis * participant able to expectorate * participant with sign of acute respiratory infection exclusion criteria: * participant not able to expectorate * patient refusing to participate

Keywords: expectoration cystic fibrosis nasopharyngeal viral molecular diagnosis
a study of the novel drug dimebon in patients with huntington's disease

Conditions: Huntington's Disease

Summary: this study will evaluate the safety of 3 months of dimebon dosing and the efficacy of dimebon in improving cognitive, motor, and overall function in subjects with huntington's disease.


Eligibility criteria:
inclusion criteria: * clinical features of hd and a confirmatory family history of hd, and/or genetically confirmed hd; * able to take medication (capsules) by mouth. exclusion criteria: * clinical evidence of unstable medical illness; * females who are pregnant or lactating or who intend to become pregnant during the study period.

Keywords: trial of dimebon to treat patients with mild-to-moderate huntington's disease.
a study evaluating the efficacy and impact on health-related quality of life of levocetirizine in adults with seasonal allergic rhinitis

Conditions: Seasonal Allergic Rhinitis

Summary: the study objective is to investigate the efficacy of levocetirizine in reducing symptoms associated with seasonal allergic rhinitis and in improving rhinitis-related quality of life


Eligibility criteria:
inclusion criteria: * subjects with a history of sar symptoms * a positive skin prick test at least one grass allergen * moderate - severe sar symptoms at baseline * women of childbearing potential must use a medically acceptable form of contraception * 80% compliance on run in study medication and 80% compliance on completing the diary exclusion criteria: * the presence of any clinically significant comorbid disease which may interfere with the study assessments * the presence of renal disease * pregnant or breastfeeding * subject is currently participating in another clinical trial * known hypersensitivity to piperazines or any of the excipients * intake of medications prohibited before the start of the trial * subjects who started or changed the dose of immunotherapy * rhinitis medicamentosa * subjects with a recent history (within the last 2 years) of drug or alcohol abuse.

Keywords: levocetirizine xyzal seasonal allergic rhinitis total symptom score quality of life
growth hormone and heart failure

Conditions: Heart Failure, Congestive

Summary: heart failure induces modification in several neurohormonal systems. the aim of this study is to determine if the growth hormone/igf1 axis is modified in heart failure patients compared to healthy volunteers.

one hundred and sixty three heart failure patients were evaluated by clinical examination, echocardiography, exercise test and measurement of blood bnp. growth hormone and igf-1 plasma levels were determined in each patient. the same biological measurements were performed in a group of 148 healthy controls. comparisons were performed between groups for growth hormone plasma level, igf-1 plasma level and growth hormone/igf-1 index. a correlation between the severity of heart failure and the different biological parameters was searched.

Eligibility criteria:
inclusion criteria: * heart failure patients in stable condition exclusion criteria: * cancer * pituitary disease

Keywords: heart failure hormones growth substances