Kornimate/medical-research-clean huggingface dataset:
effects of inspiratory muscle training in patients with parkinson's disease

Conditions: Parkinson Disease

Summary: in this study investigators will examine the effects of inspiratory muscle training and balance training in patients with parkinson's disease

parkinson's disease (pd) is the most common type of parkinsonism and mainly due to degeneration of basal ganglions and substantia nigra occurs. balance disorders are one of the common problems in patients with parkinson's disease. these balance disorders; loss of postural reflexes, insufficiency in postural adjustments, rigidity in the trunk and extremities, and many disorders such as akinesia. because of balance disorders in patients with pd, increase in addiction to daily life activities, causes physical disability. in the case of pd pulmonary problems may be the leading cause of mortality and mortality. respiratory symptoms in these patients cause problems in weakness, swallowing, coughing, voice and speech functions. when the investigators look at the current literature, the effect of balance and respiration on parkinson's patients is found to be seperately but their effect on each other is not sufficiently emphasized. for this reason, the researchers' aim to investigate balance and postural control in patients with parkinson's disease and to increase the strength of respiratory muscles and to improve balance and postural control.

Eligibility criteria:
inclusion criteria: * diagnosed with parkinson's disease * ages between 60 and 85 years * grades 1 to 3 according to modified hoehn-yahr scale exclusion criteria: * lung surgery or diagnosed lung disease history * dementia * having a orthopedic disorder which may affect balance and/or mobility * severe dyskinesia and cognition problems

Keywords: parkinson's disease inspiratory muscle training balance training
study of incidence, of mechanisms and prognosis of the thrombopenia from patients of reanimation.

Conditions: Thrombopenia

Summary: about 40 % of the patients in reanimation are thrombopenics and the causes are not well known (reduction in platelet's production, increase in their destruction...). this protocol studies the epidemiology of thrombopenia for these patients and the impacts of cost and mortality in order to bring patients best medical cares.

about 40 % of the patients in reanimation are thrombopenics and the causes are not well known (reduction in platelet's production, increase in their destruction...). this protocol studies the epidemiology of thrombopenia for these patients and the impacts of cost and mortality in order to bring patients best medical cares.

Eligibility criteria:
inclusion criteria: * thrombopenia in reanimation exclusion criteria: * pregnancy * contraindication of myelogram

Keywords: thrombopenia reanimation thrombopenia in reanimation
refining novel culturally tailored behavioral weight loss treatment components for sexual minority women with obesity

Conditions: Obesity

Summary: obesity disproportionately impacts sexual minority women. behavioral weight loss programs are the gold standard treatment for mild to moderate obesity. the investigators have developed an online behavioral weight loss program that is effective, low-cost, and highly scalable. however, existing research suggests that tailoring treatment to address 3 well-established weight loss barriers in sexual minority women will be critical for maximizing the relevance and efficacy of behavioral weight loss for this group. the goal of the first phase of this k23 is to develop 3 novel treatment components targeting sexual minority women's weight loss barriers (i.e., minority stress, low social support, and negative body image), to pilot the program in sexual minority women with overweight/obesity, and to conduct individual qualitative interviews to elicit feedback on the intervention's acceptability, cultural relevance, usability, and feasibility that will be used to refine the program. after a pre-piloting phase (consisting of initial content piloting, interviews, and intervention refinement; anticipated n=12), 8 participants will pilot the full 3-month weight loss program and will be randomized to pilot 0-3 novel tailored components (targeting minority stress, negative body image, and social support) over the 3-month period. participants will complete quantitative and qualitative assessments of intervention acceptability and appropriateness post-treatment and the intervention will be refined.


Eligibility criteria:
inclusion criteria: * assigned female at birth and currently identify as female * self-identify a minority sexual orientation (e.g.,lesbian, bisexual) * bmi\>25kg/m2 * 18-70 years old * interested in losing weight * regular internet and e-mail access * fluent in english exclusion criteria: * significant weight loss within past 6 months (\>5%) * unable to participate in moderate physical activity * currently enrolled in a weight loss program * currently taking weight-loss medication * currently pregnant or trying to get pregnant * participated in a previous phase of this study * reports a serious mental/physical health condition that would increase potential risks of treatment to the participant (e.g., active symptoms of psychosis, suicidality, mania, alcohol/substance use, or a medical condition that is serious, active, unstable, and degenerative (e.g., chf)).

Keywords: sexual minority women lgbtq health weight loss
the effect of de-prescribing antipsychotics on health and quality of life for people with dementia

Conditions: Alzheimer Disease; Dementia; Prescribing, Off-Label

Summary: this study aims to analyze how warning letters sent to physicians prescribing high levels of the antipsychotic quetiapine affected the health and quality of life of their patients with dementia. using a randomized controlled trial conducted by the centers for medicare and medicaid services (cms) in 2015, this secondary study looks at the effects of potential de-prescribing of antipsychotics by study physicians induced by the letters. the central question is whether the intervention led to better health and quality of life outcomes by encouraging more guideline-concordant care and whether changes in physicians' prescription behavior caused unintended harms.


Eligibility criteria:
inclusion criteria: * fully enrolled in fee-for-service medicare parts a, b, and d * for nursing home patients: residing in a nursing home and has a usable nursing home assessment to measure outcomes * for community-dwelling patients: not residing in a nursing home * has alzheimer's or dementia related disease diagnosis * attributed to study physician (see study population description) exclusion criteria: * died during 90 day period used to attribute patient to physician * for nursing home patients: short-stay nursing facility patient

Keywords: antipsychotics alzheimers dementia prescribing deprescribing nursing homes long-term care
a comparison of antiarrhythmic drug therapy and radio frequency catheter ablation in patients with paroxysmal atrial fibrillation

Conditions: Paroxysmal Atrial Fibrillation

Summary: the purpose of this study is to compare radiofrequency catheter ablation and antiarrhythmic drug treatment for the maintenance of sinus rhythm in paroxysmal atrial fibrillation patients.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * paroxysmal atrial fibrillation for at least 6 months with at least 2 symptomatic episodes (patient history) during the previous month * atrial fibrillation (patient history or echocardiogram documented) resistant to at least one antiarrhythmic drug of class i or iii * documentation of at least one episode of atrial fibrillation on 12-lead echocardiogram or holter monitor exclusion criteria: * contraindications to more than 2 antiarrhythmic drugs of different classes, or to oral anticoagulants * history of any previous ablation for atrial fibrillation * intracardiac thrombus * atrial fibrillation due to reversible cause * pregnancy * contraindication to stopping oral anticoagulation (for example as a result of a mechanical cardiac valve)
the clinical performance of two reusable silicone hydrogel contact lenses

Conditions: Refractive Ametropia

Summary: the purpose of this study is to assess the clinical performance of two reusable silicone hydrogel contact lenses when worn on a daily wear basis.

in this crossover study, subjects will wear each lens product for approximately 14 days and attend 7 scheduled visits. the expected overall duration of exposure to the study products is approximately 28 days.

Eligibility criteria:
inclusion criteria: * successful wear of spherical soft contact lenses in both eyes for a minimum of 5 days per week and 8 hours per day during the past 3 months. * best corrected visual acuity (bcva) of 20/25 snellen (0.10 logmar) or better in each eye. * willing to stop wearing habitual contact lenses for the duration of study participation. * other protocol-specific inclusion criteria may apply. exclusion criteria: * any eye infection, inflammation, abnormality or disease (including systemic) that contraindicates contact lens wear, as determined by the investigator. * any use of systemic or ocular medications for which contact lens wear could be contraindicated, as determined by the investigator. * habitual wear of aohp contact lenses. * habitual wear of any daily disposable contact lenses. * other protocol-specified exclusion criteria may apply.

Keywords: myopia
endoscopic therapy of early cancer in barretts esophagus

Conditions: Early Stage Esophageal Adenocarcinoma; Barrett Esophagus

Summary: this study is being done to see if treatment for esophageal cancer can be done using endoscopy for patients ineligible for surgical or radiological therapy. the standard method of treating this type of cancer is surgical removal of the esophagus. the study will determine if removing just the cancer with endoscopy is enough treatment or if the addition of another treatment called photodynamic therapy (treatment with a red light and a drug called sodium porfimer) is needed.

participant visit requirements: screening visit which will last 1 - 2 days, if assigned to photodynamic therapy, there will be a 3 day visit for treatment. participants must return for a 1 day visit every three months for one year.

Eligibility criteria:
inclusion criteria: * non-recurrent adenocarcinoma in barrett's esophagus confirmed by two experienced gastrointestinal pathologists * no evidence of submucosal invasion * no evidence of metastatic disease in either regional or distal lymph nodes, or other organs * pre-entry ct scans of the upper abdomen and chest and endoscopic ultrasound (eus) of the tumor and regional lymph nodes are required. fusion pet scans are suggested for any indeterminate lesions * zubrod performance status 0-1 * participants must be have oral intake of greater than 1700 calories a day * patient must not have had a second malignancy, other than curable non-melanoma skin cancer or cervical cancer in situ, unless disease free for greater than or equal to 3 years and deemed cured by their hematologist and/or oncologist * staging procedures should be performed prior to study entry * all patients or legally authorized representative must sign a study-specific informed consent prior to randomization. exclusion criteria: * prior major esophageal surgery * patients who are unable to tolerate endoscopic procedures * due to the possible toxic effects of photodynamic therapy and endoscopic sedation to embryos, pregnant or lactating women or men unable or unwilling to practice contraception are excluded * patients with an uncontrolled diabetes, heart disease, or hypertension * patient and/or legally authorized representative who are unable to comprehend the study requirements or who are not likely to comply with the study parameters.
the effect of cardiac educational program on level of knowledge and satisfaction among coronary artery disease patients in north of jordan

Conditions: Coronary Artery Disease

Summary: background: although patients' education programs improve health-related knowledge that promote individual capacity to understand basic health information, there is a scarcity in the studies that address cardiac educational programs for patients with coronary artery diseases in jordan and their impact on patients' health outcomes. aim: the aims of this study are to assess the level of knowledge and satisfaction of patients with coronary artery disease and to evaluate the effect of implementing a cardiac educational program on patient's level of knowledge and satisfaction. methods: this study will be carried out using a true experimental two groups pre and post- test. the necessary information will be collected from 138 patients with cad in the north of jordan using the coronary artery disease education questionnaire (cade-q) and the patient satisfaction scale (pss). the expected outcomes include establishing foundational knowledge about the effectiveness of cardiac educational program on patient health related out comes. evidence on the effect of cardiac educational program will help patients to recover from a heart attacks, prevent future heart problems, hospital stays and death related to heart problems as well as making a necessary life style changes. keywords: coronary artery disease, educational program, patient satisfaction, patient knowledge.


Eligibility criteria:
inclusion criteria: 1. mentally competent since cognitive impairment negatively affects the comprehension of the cardiac educational program content 2. able to communicate verbally 3. able to read and write arabic language 4. more than 18 years 5. stable and the previous attack not less than 24 hours exclusion criteria: * exclusion criterion included patients with life- threatening comorbidities like (heart failure (hf), valve diseases, chronic obstructive pulmonary disease (copd), patients with pacemaker or implanted cardioverter defibrillator (icd), and any type of chronic cardiac arrythmias.

Keywords: coronary artery disease, educational program, patient satisfaction, patient knowledge.
a randomized, double-blind, placebo-controlled, dose-escalation phase 1 clinical tiral in healthy male volunteers

Conditions: Autoimmune Diseases

Summary: the safety and tolerability of single and multiple administration of dwp212525

the safety and tolerability of single and multiple administration of dwp212525 will be evaluated in healthy adult male volunteers.

Eligibility criteria:
inclusion criteria: 1. healthy adult male volunteers aged 19 to 55 years, caucasian 2. those with a body weight ≥ 50.0 kg to ≤ 90.0 kg with a body mass index (bmi) of ≥ 18.0 kg/m2 to ≤ 30.0 kg/m2 3. received a sufficient explanation on this study 4. eligible as subjects in the study exclusion criteria: 1. history of diseases such as clinically significant disease of hepatobiliary 2. following conditions applicable to clinically significant acute or chronic infections or the past history confirmed via an interview 3. hemato-oncologic diseases, including malignant tumor diagnosis 4. past history of tuberculosis infection or confirmed tuberculosis in the igra test and chest x-ray test
comparison of algorithms for rotational evaluation in atrial fibrillation

Conditions: Atrial Fibrillation; Abnormal Heart Rhythms

Summary: this is a cohort study to evaluate algorithms for mapping atrial fibrillation by mapping atrial structure and mapping electrical activity to detect focal and rotational activity.

in this study, the investigators will compare mapping approaches for atrial fibrillation ablation. first, investigators will compare approaches to map atrial structure from collected computed tomography (ct) scans or magnetic resonance imaging (mri) scans acquired routinely in patients undergoing ablation for atrial fibrillation. imaging will be acquired from a variety of clinically approved second, investigators will compare approaches to analyze electrograms collected routinely at clinical electrophysiology study (eps) in patients undergoing ablation for atrial fibrillation. electrograms will be recorded from a variety of clinically approved catheters under standard of care conditions, and will be analyzed to better understand the mechanisms for atrial fibrillation and its relationship to outcomes. the investigators anticipate analyzing data from 200 patients through december 2017.

Eligibility criteria:
inclusion criteria: * aged 21-80 yrs who underwent electrophysiology study for ablation of atrial fibrillation exclusion criteria: * poor data quality of recordings of af

Keywords: atrial fibrillation ablation abnormal heart rhythm
naspi: n-acetylcysteine vs. ascorbic acid for prevention of contrast induced nephropathy in renal insufficiency undergoing coronary catheterization

Conditions: Kidney Failure

Summary: the contrast induced nephropathy (cin) has been known to be associated with significant clinical and economic consequences. many studies were performed to find the pathophysiology and preventive measures for cin. but the results were somewhat frustrating. recently, it has been reported that the n-acetylcysteine and ascorbic acid might have preventive effects for cin by their antioxidant effects.there have been no study to compare these two antioxidant.

n-acetylcysteine and ascorbic acid may prevent the cin in the patients with underlying renal insufficiency who is undergoing the coronary angiography. the effect may derive from the antioxidant function of these two antioxidant. we studied to find which of the two antioxidants is more beneficial in prevention of cin

Eligibility criteria:
inclusion criteria: * stable angina pectoris patients * patients who required the coronary catheterization * creatinine clearance rates =\<60 ml/min using the cockcroft-gault formula * age of 19 or over 19 exclusion criteria: * pregnancy * lactation * having received contrast media within 7 days of study entry * emergent coronary angiography * acute renal failure * end-stage renal disease requiring dialysis * history of hypersensitivity reaction to contrast media * cardiogenic shock * pulmonary edema * multiple myeloma * mechanical ventilation * parenteral use of diuretics * recent use of n-acetylcysteine * recent use of ascorbic acid * recent use of statin * use of metformin or nonsteroidal anti-inflammatory drugs within 48 hours of the procedure.

Keywords: kidney failure contrast media antioxidant prevention
effect of a 16-session qigong program on physical and mental health in patients with lymphoma: a randomized controlled trial

Conditions: Lymphoma

Summary: the aim of the present study was to investigate in lymphoma patients the effects of a 16-session qigong programme (2 times a week) on physical and psychological parameters.

a randomized controlled trial was conducted (control group = 19; intervention = 20). initially 50 patients enrolled in this study but only 39 finalized the program. 52% male and 48% female with a mean (sd) age of 44.49 (10.60) years. people who have had previous experiencie in mind body practices were excluded. all the patientes received information about the study and informed consent was obtained from all participants. this study was approved by the cei-gr (c-9) ethics committee and followed the principies of the declaration of helsinki.

Eligibility criteria:
inclusion criteria: * 18 years and older; lymphoma histology graded i to iiia. exclusion criteria: * treatment that modifies the vegetative nervous system activity; people that have previous experience in mind body practices.
evaluation of gemcitest in patients with pancreatic cancer and treated by chemotherapy

Conditions: Pancreatic Cancer

Summary: pancreatic cancer has a 5-year overall survival rate around 5%. it is the 6th most common cancer in france (11 600 new annual cases in 2012) and the 4th leading cause of cancer deaths in france and europe. many translational research has tried to identify biomarkers in pancreatic cancer. only the expression of hent1 evaluated on the tumor tissue with the mouse antibody seems really relevant by providing a predictive value of the effectiveness of gemcitabine adjuvant. in a metastatic situation, there is no predictive marker of the effectiveness of chemotherapy treatments. gemcitest(tm), studied in this study, is developed by the company acobiom. test based on the qrt-pcr technology that allows the establishment of a molecular signature of 10 genes that showed its interest as a biomarker in 60 patients with metastatic pancreatic adenocarcinoma treated with gemcitabine. retrospective analysis differentiated 2 patient populations: * 22 patients with a "favorable" expression gene with a median survival of 14.9 months * 35 patients with an "adverse" expression gene with a median survival of 5.1 months primary objective: to evaluate in patients with pancreatic cancer, treated with gemcitabine alone or combined (nab-paclitaxel) or with folfirinox, the prognostic value of the gemcitest(tm) test on overall survival and response to treatment. to realize this study, only one 2.5 ml blood sample is taken before starting chemotherapy. the standard practice data is then saved. 100 patients will be included.


Eligibility criteria:
inclusion criteria: 1. cytologically or histologically confirmed pancreatic cancer 2. patient seeking first-line chemotherapy for pancreatic cancer 3. age\> 18 years 4. presence of at least 1 measurable tumor lesion according to recist 1.1 criteria 5. performance index ≤ 2 6. patient able and willing to comply with the study procedures according to the protocol 7. patient able to understand, sign and date informed consent 8. affiliation to a social security scheme. exclusion criteria: 1. contraindication to chemotherapy 2. anti-tumor therapy, experimental or not, recent in the last 4 weeks before the inclusion of the patient 3. active infection requiring antibiotics within 14 days before inclusion 4. patients unable to understand, read and / or sign informed consent 5. persons benefiting from a protection system for adults (including tutorship and guardianship) 6. pregnant or lactating women

Keywords: gemcitabine
assessment of blood glucose monitoring devices with new insight features

Conditions: Diabetes Mellitus

Summary: to investigate whether novel insight features in new bgms can improve glycemic control.


Eligibility criteria:
inclusion criteria summary: * diagnosed with t1dm or t2dm for ≥ 3 month prior to screening * currently performing smbg at home for diabetes management decisions * willingness to notify the study staff if they become pregnant during the study * willing to sign an informed consent exclusion criteria summary: * is unlikely to be compliant with the diabetes regimen in the opinion of study staff * currently pregnant or planning pregnancy within duration of study or breast feeding; subjects who become pregnant during the study will be withdrawn * conflict of interest
malglycemia in the pediatric hematopoietic stem cell transplant population

Conditions: Stem Cell Transplant Complications; Hyperglycemia; Hypoglycemia

Summary: this is a retrospective chart review of patients who underwent a hematopoietic stem cell transplant (hsct) between 1994 and 2016 to evaluate incidence of malglycemia and the relationship to specific outcomes.

this is a retrospective chart review of patients who underwent a hematopoietic stem cell transplant between 2007 and 2016 to evaluate incidence and risk factors of malglycemia. the review will also aim to characterize relationships between specific outcomes and malglycemia in pediatric hsct patients.

Eligibility criteria:
inclusion criteria: * age 0 to 30 years old at time of transplant * bone marrow transplant (bmt) recipient at children's hospital colorado (chco) between 1/1/2007 and 7/31/2016 exclusion criteria: * preexisting diabetes mellitus or known hyperglycemia * inadequate blood glucose data for analysis