Kornimate/medical-research-clean huggingface dataset:
action regulation behavioral

Conditions: Parkinson Disease

Summary: parkinson's disease (pd) is a neurodegenerative disorder involving a part of the brain that is responsible for motor control, which not only results in changes or disruptions in movement, but also cognitive dysfunctions. given that the decline of muscle control such as tremors, with difficulty walking or the ability to switch tasks once in movement, greatly affects the quality of daily life. action regulation is a critical executive function (cognitive control over behavior), which includes actions such as suppressing activity when selecting between options, making decisions about stopping unwanted or inappropriate actions, and switching to new actions in response to environmental changes. parkinson's disease (pd) has been shown to disrupt action inhibition which can be considered a measure to the progression of pd. the purpose of this research study is to better understand the mechanism of action regulations in pd patients and how action regulations in pd can be improved using dopaminergic treatment, which is a drug that either releases or involves dopamine, which is a neurotransmitter involved in sending signals to nerve cells. you are asked to participate in this research study because you are receiving a dopaminergic medication for treatment of your parkinson's disease. there is currently no theory that integrates the mechanisms of action regulation into a unified framework, which this study aims to address. the researchers hope to learn more about the mechanisms of action regulation in pd patients and to help decrease action regulation disruptions in pd patients. this study will help characterize the motor behavior of pd patients.


Eligibility criteria:
for parkinson's disease patients: inclusion criteria: * diagnosis of parkinson's disease by a movement disorder neurologist * levodopa responsive with clearly defined "on" periods, with at least 30% improvement in updrs iii scores on vs off * willingness and ability to complete the behavioral experiments for up 3.5 hours * no vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators exclusion criteria: * patients with history of secondary parkinsonism, stroke, or progressive central nervous system disease other than parkinson's disease * patients with a disease or condition that prevents understanding or communication of informed consent, study demands, and testing protocol including cognitive decline, diagnosed forms of dementia, significant memory impairment (moca\<23), or hearing loss that prevents adequate communication with researcher for healthy subjects: inclusion criteria: * no history any diagnosed neurological disease(s), including movement disorders or cognitive decline * no vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators

Keywords: levodopa medication motor cortex basal ganglia
comparison between laser, synthetic gel and herbal gel as topical agents after gum surgery

Conditions: Gingival Overgrowth

Summary: this study would be conducted to assess the effectiveness of low-level laser therapy, hyaluronic acid gel and herbal gel as adjunctive aids in the healing of gingivectomy wounds. as the gingivectomy wound heals by secondary intention, this study aims to compare the healing potential of low-level laser therapy, hyaluronic acid gel and herbal gel when applied topically at baseline, 1st day,3rd day and 7th day after gingivectomy procedure.

low-level laser therapy applied to soft tissues stimulates specific metabolic processes in healing wounds. major changes observed in wounds treated with low-level laser therapy(lllt) include increased healthy granulation tissue formation with early epithelization, increased fibroblast proliferation and matrix synthesis. hyaluronic acid is a polysaccharide gel and it has many properties that make it a potentially ideal molecule for assisting in wound healing by inducing early granulation tissue formation, inhibiting inflammation, providing epithelial turnover and also aiding in connective tissue angiogenesis. hiora gel is a herbal astringent gel which helps in wound healing, reduces inflammation and also alleviates pain.

Eligibility criteria:
inclusion criteria: gingival enlargement index greater than or equal to 2mm exclusion criteria: infrabony pockets diabetic patients smokers. -
observational study for patients with newly diagnosed (mcl) not eligible for high-dose therapy

Conditions: Mantle Cell Lymphoma

Summary: this is an observational study aimed to analyze the effectiveness of treatment of patients with newly dg. mantle cell lymphoma not eligible for high-dose therapy and autologous stem cell transplantation. scheme of treatment: alternating cycles of r-chop (rituximab, cyclophosphamide, hydroxydaunomycin, oncovin, prednison) and r-arac (rituximab, cytarabin): r-chop / r-arac / r-chop / r-arac / r-chop / r-arac. the study was proposed based on the previously published data in the younger patients, which demonstrated improved outcome after implementation of ara-c into induction.

this is an observational study considered for patients with mantle cell lymphoma meeting the basic inclusion criteria. the study will enrol patients who will be treated according to standard protocol used in the hematologic department. scheme of treatment: alternating cycles of r-chop and r-arac: r-chop / r-arac / r-chop / r-arac / r-chop / r-arac. baseline procedures: * ct or pet-ct (positron emission tomography with computed tomography)before starting treatment, after 3 cycles and at the end of treatment (after 6 cycles) * bone marrow examination before therapy, after 3 cycles and after completion of induction * maintenance rituximab based of standards of each centre the study was proposed based on the previously published data in the younger patients, which demonstrated improved outcome after implementation of ara-c into induction. primary objectives include response after induction by pet-ct and pfs (progression-free survival). secondary objectives include os (overall survival), and prognostic significance of minimal residual disease detection after completion of induction

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of mcl (hematopathologic examination in the reference centre, with evidence of cyclin d1 or translocation t(11;14) ) * not eligible for high-dose therapy with autologous stem cell transplantation * eligible for r-chop or r-coep-based therapy * signed informed consent form with the study and data processing exclusion criteria: * non compliance of a patient * cns (central nervous system) involvement with lymphoma * ecog (eastern cooperative oncology group) \>3 or active uncontrolled comorbidities

Keywords: mantle cell lymphoma minimal residual disease cytosine arabinoside
human biological responses to low level ozone

Conditions: Environmental Exposure; Nasal Inflammation

Summary: to investigate if low level ozone exposure will cause measurable inflammation in nasal cells.

air pollutants including ozone have been implicated in affecting health outcomes. in particular, high level ozone exposure has been shown to affect pulmonary function and cause pulmonary inflammation. troubling community-based work has implicated high ozone levels as being correlated with increased pediatric asthma emergency room visits. because of adverse health effects, epa standards for safe ozone levels have been set, currently at 0.07 ppm. still, it is estimated that 100 million americans live in areas where ozone levels periodically remain above the epa standard. and while this epa standard had been set based on available data, it remained unclear at the time whether naturalistic low-level ozone exposure, such as fluctuations between 0.06-0.08 ppm throughout the day, might affect health as well. this group previously examined lung function and inflammatory response in adults exposed to low-level ozone, 0.06 ppm exposure for 6.6 hours, while undergoing intermittent moderate exercise. the investigators found that in response to low-level ozone exposure (0.06 ppm) with exercise, lung function declines and neutrophilic airway inflammation is observed. what remains unclear, is whether low-level ozone alone - without exercise - will cause similar health effects. to mimic exposure to ozone on a typical summer day in a polluted city, the investigators will expose subjects to a varying level of ozone, form 0.06 ppm to 0.08 ppm, rather than a constant 0.07ppm. the variation from 0.06ppm to 0.08ppm, then back to 0.06ppm will occur each hour.

Eligibility criteria:
inclusion criteria: * males and females between 18 and 50 years of age. * vital signs within normal limits on admission to the study: peripheral oxygen saturation (spo2) \> 94%, systolic blood pressure between 150-90 mm hg, diastolic blood pressure between 100-60 mm hg, afebrile. * forced expiratory volume (fev1) of at least 80% of predicted. exclusion criteria: * any chronic medical condition considered by the pi as a contraindication to the exposure study, including significant cardiovascular disease, diabetes requiring medication, chronic renal disease, chronic thyroid disease, or kidney disease. * use of systemic or inhaled steroids. * use of nsaid or aspirin within 7days of each study visit, and inability to withhold these medications prior to each session of the study. * pregnant or nursing women * use of cigarettes or other inhaled nicotine products within the past year, or more than a lifetime 5 pack year history of cigarette smoking.

Keywords: air pollution air pollutant exposure ozone
the effect of virtual reality and distraction cards on pain

Conditions: Smear Layer; Cervical Cancer

Summary: when the literature is examined, it is seen that virtual reality and distraction cards are used during medical procedures, and they have a reducing effect on pain perception and lowering the level of anxiety . on the other hand, no study has been found in the literature on the application of virtual glasses and distraction cards to women in the pap-smear process. however, in accordance with the results of the study conducted with the application of virtual reality glasses and distraction cards, it is thought that the application of virtual glasses will have a positive effect on reducing the perceived pain of women in the pap-smear process of distraction cards.

cervical cancer is the fourth most common cancer worldwide. cervical cancer is one of the most successfully treatable types of cancer, as long as it is detected early and managed effectively. who recommends the use of pap-smear and hpv dna primary screening test to prevent cervical cancer in women. . the crude incidence of cervical cancer per 100,000 women in turkey in 2020 is . who has targeted a threshold of 4 per 100,000 women by 2030 for countries to eliminate cervical cancer. to achieve this goal, 90% of girls should be vaccinated with hpv until the age of 15, and 70% of women should be screened with high performance pap-smear and hpv dna at the age of 35 and 45 for this reason, it is seen that the pap-smear test has an important place in the protection of women's health. for the pap-smear test procedure, gynecological examination and speculum examination are included . experiencing pain, anxiety, shyness and fear during gynecological examination are among the barriers to applying for and taking the pap-smear test, which has an important place in protecting women's health in the literature, it is seen that virtual reality glasses and distraction cards, which are cognitive behavioral techniques, are used during medical procedures and have a reducing effect on the perception of pain and reduce the level of anxiety . no study has been found that examines the effect on satisfaction and satisfaction levels. however, in line with the results of the study, it is thought that the pap-smear procedure will have a positive effect on women's perceived pain and anxiety, and increase their satisfaction levels. it emphasizes the need for cost-effective and feasible non-pharmacological methods by healthcare professionals during pap-smear application.

Eligibility criteria:
inclusion criteria: * 30-65 years old, to see menstruation on the day of the operation, turkish literate, no history of cervical surgery no active mental illness did not use any pain or anxiety medication prior to the insertion procedure exclusion criteria: * those with visual and auditory disabilities, using misoprostol during the procedure, using pain medication before the procedure

Keywords: virtual reality distraction cards pain anxiety pap-smear
parkinson's disease in home rehabilitation services

Conditions: Parkinson Disease

Summary: introduction: home rehabilitation is a form of care that is part of most health systems. patients with parkinson's disease can be referred to these home rehabilitation services given the characteristics of the pathology they suffer. objective: know and analyse the clinical-epidemiological characteristics of patients with parkinson's disease referred to a home rehabilitation service belonging to health area v of gijón, asturias, spain. study design: this project proposes an observational and retrospective study. study population: the subjects that will be part of this study will be men and women with parkinson's disease who have been referred to the home rehabilitation service from 2015 to 2021.

introduction: home-based rehabilitation is a care modality that is part of most healthcare systems. in most cases, patients are referred from hospitals, by the rehabilitation services themselves or by the specialist physicians who have treated them. patients who may be candidates for home rehabilitation often have difficulties in accessing a hospital or outpatient centre independently, due to difficulty in walking and/or architectural barriers within or outside the home, so that in order to travel to outpatient centres, they need means of transport such as ambulances, which entails high costs. patients with parkinson's disease can be referred to these home rehabilitation services. objectives: general: know and analyse the clinical-epidemiological characteristics of patients with parkinson's disease referred to a home rehabilitation service belonging to the health area v of gijón. specific: assess the distribution of patients by age group, sex, social conditions and degree of functional impairment. find out the time needed for recovery or completion of treatment, as well as the criteria for discharge. obtain information on the social assessment and architectural barriers of parkinson's disease patients referred to a home rehabilitation service. study design: the present project proposes to carry out an observational, ex post facto, retrospective study. the subjects who will be part of this study will be men and women with parkinson's disease who have been referred to the home rehabilitation service from 2015 to 2021. available data from the entire population of patients with parkinson's disease who meet the inclusion criteria will be analysed. limitations: the limitations of the present study are that the patients will be analysed within a specific setting, such as a home rehabilitation service, so it is possible that some results cannot be generalized.

Eligibility criteria:
inclusion criteria: * men and women with parkinson's disease * patients belonging to health area v of the health system of the principality of asturias, spain. * subjects who have been referred at some point to home rehabilitation. exclusion criteria: - patients who have been discharged at the first medical visit.

Keywords: parkinson disease parkinsonian disorders home care services home care agencies rehabilitation physical therapy modalities
assessment of ppg & pat to detect upper airway obstruction in patients with obstructive sleep apnea

Conditions: Sleep Apnea, Obstructive

Summary: the goal of this study is to collect raw waveform data for two separate noninvasive methods, both of which may be useful for the assessment of upper airway obstruction.


Eligibility criteria:
inclusion criteria: * patients twenty-one years of age or older exclusion criteria: * patient refusal to participate in study * patients under 21 (twenty-one) years of age, * referring physician's refusal to have his/her patient participate in the study. * patients with cardiac dysrhythmia (arrhythmia), including atrial fibrillation, and frequent premature atrial and/or ventricular contractions. * inability to obtain a sotera cuff pressure and/or ppg signals

Keywords: sleep apnea
atrial fibrillation ablation versus atrioventricular nodal ablation with conduction system pacing in heart failure

Conditions: Atrial Fibrillation, Persistent; Heart Failure

Summary: the goal of this clinical trial is to evaluate two treatment strategies in patients with chronic atrial fibrillation and heart failure, who are eligible for atrial fibrillation ablation. patients will be randomized to either atrial fibrillation ablation or to implantation of a pacemaker with conduction system pacing followed by atrioventricular node ablation. the effect of treatment allocation on total mortality, cardiovascular hospitalization and heart failure hospitalization will be compared.

aim to compare clinical outcome with a strategy of conduction system pacing and atrioventricular nodal ablation (csp+avna), versus atrial fibrillation (af) ablation by pulmonary vein isolation (pvi) in patients with persistent atrial fibrillation (af) and heart failure (hf), to guide future management of these patients. hypotheses 1. csp+avna is superior to af ablation in patients with persistent af and hf for reducing mortality and cardiovascular hospitalization. 2. csp+avna is non-inferior to af ablation in patients with persistent af for reducing mortality and heart failure hospitalization. design investigator-initiated, prospective randomized, controlled, open-label, multicentre study conducted in \~ 30 centres from 14 countries in europe with expertise in csp and af ablation. sample size 220 patients study duration 4 years

Eligibility criteria:
inclusion criteria: (i) persistent af with symptomatic hf despite medical therapy, considered to be suitable for af ablation, with at most one previous pvi procedure. (ii) at least one prior hospital admission, or emergency room / hf clinic visit for hf in the past 2 years, with nt-pro-bnp \> 1000 pg/ml or bnp \> 250 pg/ml measured at any timepoint during this interval. (iii) previous or current rate or rhythm control drug therapy. (iv) age \> 60 years exclusion criteria: (i) nyha class iv and systolic blood pressure ≤80 mmhg despite optimized therapy. (ii) life expectancy \< 2 years. (iii) need for major surgical intervention. (iv) myocardial infarction, stroke or pci within the previous 3 months. (v) previously implanted or planned implantation of crt device or pacemaker. implantable cardioverter defibrillator (icd) implantation without a pacing indication is acceptable. (vi) participation in another controlled trial. (vii) inability to sign and informed consent form.
extension pin block vs pin orthosis-extension block pinning for bonny mallet fractures

Conditions: Mallet Finger

Summary: this is a single center prospective study comparing the extension pin block vs pin orthosis-extension block pinning for bonny mallet fractures.

mallet finger is a fracture of the distal phalanx involving the dorsal articular surface. it is important because it concerns the extensor tendon attachment site. the clinical manifestation of mallet finger formation is active extension loss at the dip joint. if the injury is not treated and becomes chronic, the dip passive extension is gradually lost and a hyperextension posture occurs in the pip joint due to the compensatory swan neck deformity. non-surgical methods have an important place in the treatment of mallet finger injuries. the indications for surgical treatment of mallet finger injuries are a matter of debate. conditions that are widely accepted as definite surgical indications are open injury, individuals who cannot work with a splint, the ruptured dorsal part is large and includes more than 30% of the articular surface, and the presence of palmar subluxation in the dip. among the mallet finger surgical treatments, the extension pin block technique , bracing in extension, hook method are defined. in this prospective study, we aimed to compare the extension pin block technique with the pin orthosis-extension block pinning. in comparison, the patients eligible for the study will be evaluated according to crawford criteria for function evaluation, complications (infection, nail deformities, skin necrosis, dip joint osteoarthritis), recovery time.

Eligibility criteria:
inclusion criteria: * 18 years and older patients * wehbe classification type 2 b (type definition) i no dip joint subluxation ii dip joint subluxation iii epiphyseal and physeal injuries subtype a avulsed fragment \ 2/3 of articular surface ) * isolated bonny mallet fractures * minimum 1 year follow up * good cognitive status exclusion criteria: * patients under the age of 18 * open fracture * chronic mallet finger * tfracture area that includes more than 50% of the joint face * patients whose follow-up less than 1 year
dnx-2440 for resectable colorectal liver metastasis

Conditions: Liver Metastases; Liver Metastasis Colon Cancer; Colorectal Cancer; Breast Cancer; Gastric Cancer; Periampullary Cancer; Melanoma; Renal Cell Cancer; Sarcoma; Squamous Cell Carcinoma; Gastrointestinal Stromal Tumors

Summary: the purpose of this study is to test an experimental oncolytic adenovirus called dnx-2440 in patients with resectable multifocal (≥ 2 lesions) liver metastasis, who are scheduled to have curative-intent liver resection surgery. up to 18 patients will receive two sequential intra-tumoral injections of dnx-2440 into a metastatic liver tumor prior to surgery for liver resection, to evaluate safety and biological endpoints across 3 dose levels (dose escalation). upon conclusion of the dose-escalation phase, the selected safe and biologically appropriate dose will be administered using the same schema for an additional 12 patients with colorectal cancer liver metastasis (expansion cohort) using established biologic endpoints.


Eligibility criteria:
key inclusion criteria: * male or female aged ≥ 18 years at time of consent * diagnosis of liver metastases from colorectal, breast, gastric, periampullary, melanoma, renal cell cancer, sarcoma, squamous cell carcinoma or gastrointestinal stromal tumor * multiple (≥ 2) liver tumors * candidate for curative-intent surgery * stated willingness to comply with all study procedures and availability for the duration of the study. * candidates eligible for targeted therapy, as per standard of care guidelines (and based on mutational status as indicated), must have completed therapy * preoperative chemotherapy is allowed key exclusion criteria: * recurrence of liver metastasis * diagnosis of neuroendocrine tumor liver metastasis * liver metastasis treated with \> 12 cycles of systemic chemotherapy * condition that requires ongoing systemic immunosuppressive therapy * evidence of inadequate organ function based on lab parameters * liver transaminases (aspartate aminotransferase \[ast\] and/or alanine aminotransferase \[alt\]) or total bilirubin \> 5x the upper limits of normal * males or females who refuse to use a double-barrier form of birth control during the study and for up to 6 months after injection with dnx-2440