Kornimate/medical-research-clean huggingface dataset:
progressive rehabilitation following total knee arthroplasty

Conditions: Osteoarthritis

Summary: the purpose of this study is to evaluate the effectiveness of a progressive resistance rehabilitation program (prog) after total knee arthroplasty (tka) compared to a traditional rehabilitation program (trad). the investigators hypothesized: * prog will result in greater improvements in functional outcome measures such as: stair climbing test (sct), timed-up-and-go test (tug), six minute walk test (6mw), the knee injury and osteoarthritis outcome survey (womac), and knee range of motion (rom). * prog will result in greater improvements in quadriceps muscle strength gains after tka compared to trad. * prog will result in greater improvements in muscle mass and central activation compared to trad.

over 500,000 total knee arthroplasties (tkas) are performed each year in the united states to alleviate pain and disability associated with knee osteoarthritis (oa), and this number is expected to grow to 3.48 million per year by the year 2030. tka reduces pain and improves self-reported function compared to pre-operative levels, but post-operative deficits in walking speed (20% slower) and stair climbing speed (50% slower) can persist for years. stair climbing performance is the single largest residual deficit after tka with seventy-five percent of tka patients reporting difficulty negotiating stairs after surgery. collectively, these findings suggest that current rehabilitation does not adequately target the impairments that lead to long-term deficits in functional mobility after tka. the aim of the proposed trial is to evaluate the effectiveness of a progressive resistance rehabilitation program (prog) after tka compared to a traditional rehabilitation program (trad). the prog intervention will involve intensive rehabilitation using progressive resistance exercise and faster progression to functional strengthening exercises. the trad intervention represents the synthesis of previously published tka rehabilitation programs. our preliminary data suggest that the prog intervention has low risk and results in improved functional mobility and muscle strength. the investigators will measure function and strength at six time points (pre-op; 1, 2, 3, 6, and 12 months after tka). the investigators will also evaluate the contribution of changes in muscle mass (atrophy/hypertrophy) and central activation to changes in muscle strength following prog and trad interventions.

Eligibility criteria:
inclusion criteria: * undergoing a primary, unilateral knee arthroplasty * body mass index \< 40 kg/m2 exclusion criteria: * severe contralateral leg oa (\< 5/10 pain with stair climbing) or other unstable orthopaedic conditions that limit function * neurological conditions that affect muscle function * vascular or cardiac problems that limit function * uncontrolled diabetes * pregnancy

Keywords: total knee arthroplasty quadriceps muscle arthroplasty joint diseases musculoskeletal diseases
cardiovascular health in adult patients with cancer exposed to cardiotoxic therapies

Conditions: Cardiac Toxicity; Cancer

Summary: the goal of this observational study is to evaluate the cardiovascular health and prognosis of adult patients with cancer, treated with cardiotoxic therapies. the main purposes of the study are the following: * identify the demographic factors related to the onset of cardiotoxicity produced by anticancer drugs. * identify any subgroups more likely to develop distant major adverse cardiovascular events (mace). * evaluate the usefulness of clinical, biohumoral and echocardiographic parameters for early diagnosis of cardiotoxicity. participants will be monitored during the anticancer treatment via clinical, laboratory and instrumental evaluation according to the recommendation of the current guidelines on cardio-oncology (european society of cardiology, 2022). initial follow-up will be 2 years.

the goal of this observational study is to evaluate the cardiovascular health and prognosis of adult patients with cancer, exposed to potentially-cardiotoxic therapies. the main purposes of the study are the following: * identify the demographic factors related to the onset of cardiotoxicity produced by anticancer drugs. * identify any subgroups of patients more likely to develop distant major adverse cardiovascular events (mace). * evaluate the usefulness of clinical, bio-humoral and echocardiographic parameters for early diagnosis of cardiotoxicity. participants will be monitored during the anticancer treatment via clinical, laboratory and instrumental evaluation according to the recommendations of the available guidelines on cardio-oncology (european society of cardiology, 2022). initial follow-up will be 2 years.

Eligibility criteria:
inclusion criteria: * patients over the age of 18 at the time of evaluation * patients treated with potentially cardiotoxic anticancer drugs * patients for which complete clinical, electrocardiographic and echocardiographic data are available at first evaluation and at least at one follow-up visit. exclusion criteria: * patients under the age of 18 at the time of evaluation * patients whose documentation of the first visit is not available * patients for whom it is not possible to obtain follow-up information through a medical visit or by telephone * patient with poor acoustic window for echocardiographic examination. * refusal of informed consent to participate in the study.
s-32 pg 242 short stem

Conditions: Osteoporosis

Summary: the data of calibrated ct-scans will be used for the finite element analysis (fea) analysis for smr short stem in identified hospitals in eu and us as developers of the project and for further research, upon subject acceptance. in particular, the quantitative computer tomography (qtc)/finite element analysis (fea) model of the assembly consisting of the shoulder and the orthopaedic implant allows detailed analyses including: * assessment of micromotion at the bone-implant interface, to predict osseointegration; * comparison of strains/stresses between the intact bone tissue and the bone with the implant in order to predict the stress shielding phenomenon.


Eligibility criteria:
inclusion criteria: * 1. subjects (males and/or females) must be ≥ 18 years of age 2. subjects are willing and able to provide written informed consent for collection of the data; if a patient has already completed and performed the calibrated ct-scans as per standard clinical practice, the subject may be contacted to offer participation in the study. 3. adult patients who will undergo noncontrast ct scanning of the shoulder as part of routine preoperative planning for shoulder arthroplasty will be eligible to participate in the study and receive a calibrated ct scan of the shoulder. the decision to undergo ct scan will be made independently of study participation; only patients who require a ct scan of the shoulder for clinically necessary reasons are eligible to participate. exclusion criteria: * 1. pregnancy or lactation; 2. subjects who have fracture of the affected shoulder; 3. subjects who have had prior surgery on the affected shoulder that resulted in metal implants, including but not limited to: * partial or total shoulder joint replacement; * open reduction internal fixation of fracture; * prior rotator cuff repair with metal implants; 4. local or systemic infection; 5. persistent acute or chronic osteomyelitis; 6. focal vascular or neurologic diseases affecting the concerned limb; 7. metabolic disorders or systemic diseases that substantially affect bone quality, including the following: * renal osteodystrophy * osteoporosis * osteomalacia * osteopetrosis 8. bone tumors involving the shoulder girdle; 9. local or disseminated neoplastic diseases; 10. severe deformity including malunion, nonunion, excessive bone loss that would result in improper virtual implant positioning;
induced motion illusions through vision and tendon vibrations: study of interactions in hemiplegic subjects

Conditions: Hemiplegia

Summary: two movement illusion techniques can currently be used in clinical practice for motor rehabilitation after stroke hemiplegia: visual illusion (mirror therapy) and proprioceptive illusion (tendon vibration). mirror therapy, in its computerized version (ivs3, dessintey, saint-etienne, france), is based on the substitution of the deficient visual feedback by a visual feedback of a correctly realized movement. the proprioceptive illusion is based on the external application of a vibrator on muscle tendons at a frequency between 50 and 120 hz. these two techniques are currently used independently. they are, in theory, complementary and additive. no study has described the combinatorial properties of the illusions generated by these 2 techniques in hemiplegic subjects and healthy subjects.

the study hypothesis is that the administration of mirror therapy together with vibration will increase the perception of movement in a subjective scale.

Eligibility criteria:
inclusion criteria: hemiplegic subjects : * male or female * aged 18 to 70 years, * first ischemic or hemorrhagic stroke causing hemiplegic * having signed the written consent * affiliated or entitled to a social security scheme healthy subjects : * male or female, aged 18 to 70 years, * matched in sex, age and laterally with hemiplegic subjects * having signed the written consent * affiliated or entitled to a social security scheme exclusion criteria: hemiplegic subjects : * with complete lesion of the primary motor cortex * with an addiction to alcohol or drugs * with psychiatric illness, cognitive impairment, uncontrolled disease/epilepsy, malignant illness severe kidney or lung disease * with history of associated general disabling disease * with cerebellar syndrome * with clinical brain stem involvement * under legal protection * pregnant or breastfeeding women healthy subjects : * neurological, cardiovascular, musculoskeletal diseases * taking medication that can affect attention * unable to understand instructions of the study * under legal protection * pregnant or breastfeeding women

Keywords: computerized mirror therapy (cmt) intensive visual simulation3 (ivs3) vibration vibrasens upper limb rehabilitation stroke hemiplegic
lux-dx insertable cardiac monitor remote programming and performance study

Conditions: Atrial Fibrillation; Syncope; Cryptogenic Stroke

Summary: the lux-dx perform study had two primary objects which were (1) to characterize, in a general patient population, the utilization of the remote programming feature of the boston scientific (bsc) insertable cardiac monitor (icm) device and (2) to collect data to characterize the performance of arrhythmia detection algorithms. data was also collected to characterize the icm system related safety events.


Eligibility criteria:
inclusion criteria: * patient is indicated to be implanted with the lux-dx icm for one of the following reasons (grouped in three "reason for monitoring" subgroups): 1) cryptogenic stroke, 2) syncope, 3) af management, post-af ablation, or suspected af * patient is willing to enroll and be monitored in latitude clarity. * patient is willing and able to be followed remotely via the icm patient mobile app. * patient is willing and capable of providing informed consent (which is not to include the use of a legally authorized representative (lar) for documentation of informed consent) and agrees to participate in all protocol required activities. * patient is age 18 years or above, or of legal age to give informed consent specific to state and national law. the following inclusion criterion is applicable for patients participating in the holter study: • patient can tolerate the adhesive used in the holter monitoring for an extended period of time. exclusion criteria: * patient is indicated for implantation of, or is currently implanted with an active implantable cardiac device (e.g., lvad, icd, crt d, ppm\*). * patient cannot tolerate a subcutaneous, chronically-inserted device due to medical condition. * patient has a documented life expectancy of less than 12 months (per investigator's discretion). * patient is known to be pregnant at the time of study enrollment (method of assessment upon investigator's discretion). * patient is currently enrolled in another clinical study including observational studies/registries, unless prior written approval from bsc is obtained. mandatory governmental registries are accepted for co-enrollment without approval by bsc. the following exclusion criteria are applicable for patients participating in the holter study: * patient has known allergies to the adhesive materials or hydrogel used in the extended holter monitoring. * patient has broken, damaged, or irritated skin over the chest area where the extended holter monitor will be attached.
evaluation of a telehealth lifestyle management program to improve healthy behaviors post head injury

Conditions: Traumatic Brain Injury

Summary: interventions to help individuals with traumatic brain injury manage their healthy lifestyle behaviors have been limited. thus, the goal of this project is to evaluate the efficacy of a telehealth lifestyle program on reductions in weight and improvements in health behaviors/lifestyle choices.


Eligibility criteria:
inclusion criteria: 1. age 19 years or older 2. english speaking 3. sustained a moderate or severe tbi (as defined by a period of confusion after the injury of more than 24 hours) 4. overweight or obese as defined by a bmi score of ≥ 25 kg/m2 5. 1-year or greater post-injury 6. not currently enrolled in a weight loss program or receiving weight loss medication 7. regular access to a computer/laptop with internet capability which allows internet and telephone access simultaneously 8. if person with tbi who meets criteria 1-7 but does not cook, shop, and/or prepare meals independently, he or she must have a non-paid, study partner willing to participate in the study. exclusion criteria:1 1. pregnant or planning to become pregnant in the next 7 months 2. concurrent medical condition for which changes in exercise or diet would be contraindicated 3. severe hearing or visual impairment 4. significant psychiatric disorder, such as schizophrenia or bipolar disorder (those with depression or anxiety will not be excluded) 5. unable to communicate 6. significant cognitive impairment and without a study partner, and/or 7. person with tbi who does not cook, shop, and/or prepare meals independently who does not have a non-paid, study partner willing to participate in the study 8. currently enrolled in an organized weight loss program 9. has lost \> 10% of body weight over the past 6 months 10. history of an eating disorder
detection of biofilm among uropathogenic escherichia coli clinical isolates in suez canal university hospitals

Conditions: Escherichia Coli Infections

Summary: this descriptive cross-sectional study will beconducted in suez canal university hospitals (scuhs) in ismailia, egypt. the study aims to detect escherichia coli biofilm producers to improve prognosis and treatment and reduce morbidity and mortality rates due to this infection.

forty seven clinical isolates of non-duplicated upec will be collected from clinically suspected cases of uti in different departments in scuhs. isolates will be identified as e. coli by colony morphology, gram staining and biochemical reactions. antimicrobial sensitivity testing will be performed by kirby-bauer disc diffusion method on muller-hinton agar plate. the detection of biofilm will be carried out by congo red agar (cra) method and modified tissue culture plate (mtcp) method.

Eligibility criteria:
inclusion criteria: * patients showing criteria for symptomatic urinary tract infection (suti) according to center of diseases and control criteria (cdc) (cdc, 2022). patient has at least one of the following signs or symptoms: * fever (\>38.0°c) * suprapubic tenderness * costovertebral angle pain or tenderness * urinary urgency * urinary frequency * dysuria exclusion criteria: * 1. patients received antibiotic treatment in the last 48 hours 2. refusal of the patients to participate in the study

Keywords: uropathogenic e. coli biofilm antibiotic resistance mtcp cra
analysis of the mass skiers' injury in a large ski resort in chongli, china

Conditions: Skiing Injury

Summary: this study takes the injury situation of a large ski resort in chongli during the 2017-2018 and 2018-2019 snow seasons as an example, aiming to preliminarily understand the injury situation of mass skiing in ski resorts in china, and provide a basis for predicting the rapidly growing medical demand for treatment and treatment of ski injuries in the context of 2022 winter olympic games.

objective: to make a retrospective analysis of the injuries of skiing population in a large ski resort in chongli, china and provide a basis for predicting the rapidly increasing medical needs for ski injuries in the context of the 2022 winter olympic games. methods: the basic data of all injured skiers who were treated in a medical station of a large ski resort in chongli during the 2017-2018 and 2018-2019 snow seasons were collected. the number of skiers, the number of injuries, the causes of injuries, the types of injuries and the locations of injuries were compared.

Eligibility criteria:
inclusion criteria: * all of the injured in a snow season at a snow resort exclusion criteria: * none

Keywords: ski resorts skiing sports injury the winter olympics
eeg-based personalized transcranial magnetic stimulation (etms) to treat post-traumatic stress disorder

Conditions: Stress Disorder, Post Traumatic

Summary: this is a randomized, sham controlled study of the electroencephalogram (eeg) based transcranial magnetic stimulation (etms) treatment for post-traumatic stress disorder (ptsd). the recruitment goal is 110 participants who are united states military veterans or first responders (e.g., firefighters, police, paramedics, etc.). the study includes an eeg recording in order to determine the optimal treatment parameters for the etms system, followed by 15 in-office visits that take place over 21-28 total days. two etms treatment sessions are administered during each office visit.

etms-ptsd-001 stage 2 is a randomized, sham controlled study with a recruitment goal of 100 subjects, with 99 completers. the study is intended to evaluate the safety and efficacy of etms in the target population. a maximum of 800 individuals will be screened in order to achieve the recruitment goal. the total number of days from the first participant enrolled to the last enrolled participant treated will be approximately 10 months. participants will be either veterans or first responders (e.g., emergency medical service provider, firefighter, or any other emergency response personnel), between 22-65 years of age. participants may be male or female of any racial/ethnic background who meet the eligibility criteria. participants will be recruited from the general public, and from veterans and first responder organizations. the primary outcome for the study will be reduction in ptsd symptoms as calculated by the ptsd checklist for dsm-5 (pcl-5) assessment.

Eligibility criteria:
inclusion criteria: * willing and able to consent to participate in the study via signed informed consent * age 22 - 65 years * diagnosis of ptsd according to dsm-5 criteria via the clinician-administered ptsd scale (caps). * onset of symptoms meeting the dsm-5 criteria for ptsd symptoms persisting for a minimum of 6 months prior to the screening visit * veterans administration pcl-5 cut point score of 31 or above * positive identification as either a veteran, or first responder (e.g., emergency medical service provider, firefighter, or any other emergency response personnel) exclusion criteria: * uncontrolled medical, psychological or neurological condition * pregnant, or female unwilling to use effective birth control during the course of the trial * metal objects in the head * past exposure to metal fragments, permanent piercings, and/or other possible metal sources in the head and neck * current participation in any interventional research protocol * history of any type of electroconvulsive therapy (ect) or repetitive transcranial magnetic stimulation (rtms) * history of stroke or intracranial lesion or increased intracranial pressure * history of epilepsy of seizure * family history of epilepsy or seizure in 1st degree relative * an elevated risk of suicide or violence to others

Keywords: ptsd veterans first responders
study of mdw levels predicting the development of sepsis in hospitalized hiv-infected patients and correlation with prognosis

Conditions: HIV Infections; Sepsis

Summary: sepsis is a common and critical complication in hiv-infected patients and an important marker of high risk of patient death. the widely used diagnostic criteria for sepsis still have many deficiencies and do not allow for good prediction and timely determination of the onset of sepsis. in hiv-infected patients, abnormal activation of monocyte-macrophage is also a key mechanism in the development of their sepsis. monocyte distribution width (mdw) is a marker of the degree of peripheral blood monocyte activation and has been recommended abroad for the early diagnosis of adult sepsis patients in emergency departments. however, in china, mdw has not been applied to the clinic yet, and the related studies are almost blank. therefore, it is worthwhile to analyze the monocyte activation status of hiv-infected patients by mdw assay and thus predict the occurrence of sepsis.

this is a prospective observational study, and investigators intend to collect hiv-infected patients in our hospital within 1 year from the conduct of this study and hospitalized, after informed consent, for inclusion in the study. investigators will collect clinical data, basic laboratory indicators, and test mdw levels of the patients and follow the patients until discharge or death.

Eligibility criteria:
inclusion criteria: * positive elisa test results for hiv-1 antibodies; * hospitalized patients; voluntarily signing the patient's informed consent and being able to promise to be followed up; * no plans to move away from the current trial site during the course of the trial. exclusion criteria: * western blot and/or hiv rna assay confirmed as hiv negative; * women who are pregnant or breastfeeding; * current drug users; * persons with a history of alcohol abuse that cannot be terminated; * persons of non-chinese nationality; * other patients who, in the judgment of the investigator, are deemed unsuitable for participation in this trial.