Kornimate/medical-research-clean huggingface dataset:
clinical comparison of restorative materials

Conditions: Dental Caries

Summary: composite resin materials are the first treatment choice in direct restorations due to their good mechanical properties, excellent esthetic properties, conservative preparation, and successful clinical performance. however, resin-based composite materials in deep cavities are more likely to irritate the pulp tissue due to insufficient polymerization and residual monomer release. therefore, glass ionomer-based restorative materials can be used more successfully in deep cavities. in addition, the hardening mechanisms of high-viscosity glass ionomer cement are the same as those of conventional glass ionomer cement, and their wear resistance, surface hardness, compression, and bending strength are increased. no clinical studies evaluate the performance of different restorative materials in deep cavities. this clinical study aims to evaluate the clinical performance of high-viscosity glass ionomer, bulk-fill composite, and conventional composite in deep cavities.

this study was a double-blind (evaluator and patient) randomized controlled clinical study with three study groups with an equal allocation. three different restorative materials were compared in deep cavities. the treated patients were called back for controls after one week, six months, and twelve months. restorations were evaluated clinically according to modified fdi criteria (marginal discoloration, color match, anatomical form, fracture and retention, marginal adaptation, contact point, post-operative sensitivity, secondary caries and periodontal response). clinical evaluation was performed by one qualified clinicians using a mirror and probe under reflector light. bite-wing radiographs were taken from the patients who were called for controls at 6-moth and 12-month to evaluate the formation of secondary caries. differences between adhesives at each time period were evaluated using fisher's exact test. the effect of time on restorations was evaluated using wilcoxon signed rank test (p \< 0.05).

Eligibility criteria:
inclusion criteria: * systemically healthy patients aged 18 and over * patients with good oral hygiene. * vital teeth are to be included in the study. * the presence of an antagonist and a contact tooth for the tooth to be restored. * teeth with deep caries lesions or radiographically reaching ¾ of the dentin but with a hard dentin region between the caries and the pulp according to ese (european society of endodontology) criteria. exclusion criteria: * patients with a history of bruxism and periodontal disease * patients under 18 years of age * spontaneous pain in the tooth to be restored * intense carious lesion reaching the entire thickness of the dentin according to ese (european society of endodontology) criteria * observation of mechanical perforation during caries cleaning * patients suspected of pregnancy or pregnant

Keywords: dental caries restorative material composite resin deep caries
losartan and uric acid metabolism in children with proteinuric nephropathies

Conditions: Uric Acid Nephropathy

Summary: the aim of this study is to assess the serum uric-acid lowering effect of losartan in children with proteinuric nephropathies. patients already treated with enalapril will be randomized to receive losartan and/or enalapril in a cross-over designed study. those who recruit the inclusion criteria will receive enalapril and/or losartan during a one month period, followed by a 15 days of wash out (under enalapril treatment). on day 46, the second period of 30 days of treatment start (enalapril or losartan, whichever was not received initially). before randomization, a baseline 24 hours urine and a fasting blood sample will be obtained to assess uric acid excretion and serum uric acid values along with renal function and electrolyte levels. then, similar determinations will be performed at days 30, 46 and 76.

the working hypothesis is that the administration to losartan reduces significantly the serum uric acid levels in normotensive children with proteinuric nephropathies. the study will consist in a single center cross-over randomized, open label, clinical trial. inclusion criteria will be:children with poteinuric nephropathies already treated with enalapril under our care, age between 3 and 12 years and normal blood pressure. subjects will be selected by simple probability sampling and after the signature of the assent/informed consent, they will be randomized (blocks of 4 patients, treatment sequence 2:2) to receive a two phases regime of drugs: 1) arm enalapril-losartan, or 2) arm losartan-enalapril. between phases there will be a 14 days wash out period (during this time patients will continue receiving enalapril, as this drug does not have effect on uric acid metabolism). the dose of enalapril will be that they usually receive, while the dose of losartan will be 5 times the those of enalapril that they usually receive. visit schedule: day 1 (randomization) and 30 for the first drug; 15 days wash out period, day 46 and 76 for the second drug. in each visit a physical examination and blood pressure monitor will be performed, along with the following laboratory parameters: urea, creatinine, electrolytes, uric acid, glycemia, triglycerides, cholesterol and lipopolysaccharides. simultaneously, in a spot urine morning sample will be determined the levels of uric acid, creatinine, proteinuria y albuminuria.

Eligibility criteria:
inclusion criteria: * children with poteinuric nephropathies already treated with enalapril under our care. * age between 3 and 12 years. * normal blood pressure. exclusion criteria: * patients with high blood pressure. * post menarche female patients. * patients with hypouricemia (\< 2 mg/dl). * patients treated with diuretics. * patients with absolute or relative contraindications to receive raas antagonists (glomerular filtration \ 5,5 meq/l). * patients with active rheumatic diseases. * patients treated with dual blockade of the raas (enalapril +losartan). * patients treated with calcineurin inhibitors.
a cognitive behavioral therapy-based text messaging intervention for methamphetamine dependence

Conditions: Methamphetamine Dependence

Summary: this phase i, randomized, 22-day crossover study seeks to improve treatment outcomes for methamphetamine-dependent subjects by developing a cognitive behavioral therapy (cbt)- based short message service (sms) text messaging intervention as an adjunct to cbt group therapy.

psychosocial therapies for methamphetamine (ma) addiction all have limited effectiveness, and patients treated for ma dependence have a high rate of relapse. additionally, there are no currently approved medications for ma dependence. thus, a significant need exists for add-on therapy for treatment of ma addiction. cbt-based text messaging could serve as a real-time intervention when craving and risk of ma use are high and patients are not in the clinic. it could further serve to reinforce cbt group therapy. if found efficacious, fully-automated cbt-based text messaging would be a relatively inexpensive adjunctive therapy that could be readily scaled up for use in a large number of patients. additionally, this type of text messaging intervention also could be tailored to individual users, which may enhance its efficacy. this phase i randomized crossover study will evaluate the feasibility and preliminary efficacy of cbt-based text messages in conjunction with cbt group therapy delivered over a 22-day period in ma users in the san francisco bay area.

Eligibility criteria:
main inclusion criterion: * english-speaking adults who are currently seeking treatment for methamphetamine addiction

Keywords: methamphetamine drug abuse substance abuse amphetamine dependence addiction craving cognitive behavioral therapy text messaging
effect of prebiotic fiber- enriched (scfos) enteral feeding on the microbiome in neurological injury trauma patients (prefeed microbiome trial)

Conditions: Enteral Nutrition; Brain Injuries, Traumatic; ICU Admission

Summary: this study plans to learn more about the impact of enteral nutrition on bacteria in critically ill trauma patients with brain injury. specifically, it seeks to understand the effect that a prebiotic containing enteral feeding formula (nutraflora scfos in vital af) has on the gut, oral, and skin bacteria. a prebiotic is a special form of dietary fiber that acts as a fertilizer for good bacteria. the prebiotic nutraflora scfos has been cleared by the u.s. food and drug administration and is not considered investigational as used in this study. enteral feeding is a way to give nutrition to critically ill people who are unable to eat.


Eligibility criteria:
inclusion criteria: 1. adult major neurological injury trauma patients between 18-70 years of age who have been admitted directly to trauma icu following major trauma 2. expected length of mechanical ventilation \> 48 hours (as judged by admitting clinician) 3. expected length of icu stay \> 3 days (as judged by admitting clinician) 4. expected to survive \> 48 hours (as judged by admitting clinician) 5. requiring enteral nutrition at any time in intensive care unit (icu) stay 6. chronic illnesses must be under control (as determined by the principal investigator). exclusion criteria: 1. previous hospitalization within one month prior to icu admission (no hospital floor transfers to eliminate confounding effect of previous hospital therapy) 2. use of prebiotic fiber containing enteral or oral formula or probiotic preparations within one week 3. received antibiotics within the previous month 4. on steroids or immunosuppressants at time of admission 5. all transplant patients 6. chronic inflammatory disease that requires steroids or other biologic therapy intervention (e.g.: ra, ibd that requires steroids or humira) 7. undergoing active chemotherapy/radiation treatment 8. renal failure requiring dialysis 9. liver cirrhosis class c

Keywords: trauma brain neurological injury enteral tube feeding nutrition
early stage retinal abnormalities in type 1 diabetes, screened with oct angiography.

Conditions: Type 1 Diabetes Patients

Summary: the improvement of imaging techniques in ophthalmology has made it possible to carry out a precise non-invasive study of the retinal microvascular network and to detect early abnormalities in retinal disorders. the presence of such early retinal abnormalities remains poorly known during type 1 diabetes and may be detected with oct-angiography. furthermore, the association with glycemic variability, likely to have deleterious effects on microvessels, has never been studied.


Eligibility criteria:
inclusion criteria: for the patient group * patient who has given consent * type 1 diabetic patient, no retinopathy for the healthy control group * patient who has given consent * non-diabetic patient for dyslipidemic control group: * person who has given consent * person with familial dyslipidemia exclusion criteria: for the patient group * presence of diabetic retinopathy * protected patient: * minor patient * pregnant, parturient or breastfeeding woman * patient under legal protection (guardianship, curatorship, court decision) * patient unable to express consent person not affiliated to a health insurance scheme for the healthy control group * ophthalmological history (vascular and degenerative macular conditions) * protected patient: * minor patient * pregnant, parturient or breastfeeding woman * patient under legal protection (guardianship, curatorship, court decision) * patient unable to express consent person not affiliated to a social security scheme for dyslipidemic control group: * ophthalmological history (vascular and degenerative macular conditions) * protected patient: * minor patient * pregnant, parturient or breastfeeding woman * patient under legal protection (guardianship, curatorship, court decision) * patient unable to express consent person not affiliated to a social security scheme
effects of multicomponent physical exercise program and mediterranean diet in alzheimer's disease

Conditions: Alzheimer Disease; Physical Exercise; Bone Density; Fall

Summary: this study is a randomized, parallel-group, single blinded controlled clinical trial. the general objective of this multicomponent physical exercise program (mpep) associated with a mediterranean diet (medi) is to decrease the risk of falls and fractures through the improvement of the bone health and physical functions of people with alzheimer disease. patients allocated to the intervention group will perform a mpep with a medi during 6 months, with a frequency of 3 sessions per week, and approximately 45-50 minutes of duration each session. during the study, 4 evaluations will be carried out to assess the effects of the interventions on bone mineral density, gait, balance, and fall risk: ((1) baseline (pre-intervention); 2) 1st post-intervention after 1 month; 3) 2nd post-intervention after 3 months; 4) final, 3rd post-intervention after 6 months


Eligibility criteria:
inclusion criteria: * patients of both sexes older than 50 years * have a diagnosis of ad * present mild or moderate cognitive impairment (mini-mental state examination (mmse) score between 11 and 23 points included) * acceptance to participate in the study (enrollment in the study and signing of informed consent) exclusion criteria: * other associated pathologies that do not allow physical exercise due to having severe functional disability or being insecure (neurological diseases, severe cardio-respiratory pathology, etc.). * impossibility to carry out the evaluation tests. * falls and other incidents with severe consequences that cause disability and/or that do not allow the intervention to continue. * attendance at the mpep is less than 75% in the total of the sessions between assessments. (criterion applied to each period between assessments). * not performing the mpep sessions for 2 or more consecutive weeks. * participate in another intervention program outside of this study, especially an exercise program (important intervention bias for the control group).
efficacy of coordinated insulin boluses in type 1 diabetic patients

Conditions: Type 1 Diabetes

Summary: a recent study suggests that, in type 1 diabetes (t1d) patients treated by insulin pumps, a better coordination of meal boluses and post prandial basal rate could reduce the importance of postprandial hyperglycaemias without increasing the risk of delayed hypoglycaemias. the aim of the investigators study is to assess if these results are confirmed in a clinical trial. the aim of this study is to compare the efficacy of coordinated boluses versus normal boluses on postprandial glycaemic control of t1d patients treated with continuous subcutaneous insulin infusion.


Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus * with confirmed negative c-peptide or diabetes duration\>5 years * treated by external insulin pump and rapid insulin analog for more than 3 months * using a medtronic paradigm real-time or veo™ model * educated to and practicing functional insulin treatment and carbohydrate counting for more than 3 months * able to use the "basal temp" and "glycaemia reminder" functions of their pump * basal infusion rate ≥ 0,5 unit/h * self-monitoring of blood glucose frequency \> 4/days * aware of hypoglycaemia exclusion criteria: * known impaired renal function (creatinin clearance \<60ml/min) * gastroparesis * serious or instable disease likely to induce a glycaemic control deterioration - treatment with corticosteroids

Keywords: type 1 diabetes
multiomics-based prediction model for gdm

Conditions: GDM

Summary: a prospective cohort study was conducted to :1. explore the relative biomarkers of related with the occurence and development; 2. develop a multiotimics prediction model for gdm.

gestational diabetes mellitus (gdm) is one of the most complications during pregnancy and it is associated with many adverse outcomes especially when the pregnant women can't control blood glucose well. with economy develop rapidly, the occurence of gdm is about 15-20%. recently, the research on gdm has gone into the molecular level, which is beneficial to diagnosis and treatment on gdm. besides, the cost of hospitalization and treatment for adverse outcomes caused by gdm have caused a certain burden to pregnant women, their families and the whole country. lifestyle management has the first-line for treatment on gdm, however, the situation of self-management on gdm isn't satisfactory. therefore, our study aims to explore a model to predict gdm in advance and reduce the adverse outcomes and economy associated with gdm. the study plan to enroll 60 participants with hisk-risk of gdm and 40 normal participants. they are required sign the inform consent after deciding to participate the research. furthermore, during early pregnancy (8-13 weeks), middle pregnancy (24-27 3 weeks) and late pregnancy (32-36 weeks), 6-8 weeks after delivery, blood, feces, urine, saliva samples were collected, and continuous blood glucose monitoring system were equipped, human component testing was performed. follow up was performed to collect the first stool sample of the mother after delivery and faecal samples from the first to the fifth time after birth (the first five times within one week after birth, including hospitalization and discharge) .

Eligibility criteria:
inclusion criteria: all of following conditions must be met: * the range of pregnant week is between 8 to 13+6 weeks; * the range of age is between 20 to 45 years; * pregnancy naturally and singleton pregnancy; * according to the 2020 gdm high-risk population scoring model, those who gets equal to or larger than 80 scores will be assigned to high-risk group and equal to or smaller than 20 scores to low-risk group; exclusion criteria: meeting one of the following conditions will be excluded: * smoking or drinking alcohols; * pregnant women who used antibiotics before 1 month enrollment; * combined with chronic hepatitis, nephritis, chronic gastritis, gastric ulcer, chronic colitis, hyperthyroidism, hypothyroidism (except subclinical hypothyroidism) and blood diseases before pregnancy; * pregnant women who has a long-term medication history; * those who reject signing the inform consent; * those who has participated other clinical trail in the same period

Keywords: gdm predictive model multiotimics
untreated sleep apnea as an aggravating factor for other secondary medical conditions after spinal cord injury

Conditions: Sleep Apnea; Spinal Cord Injuries; Spasticity, Muscle; Neuropathic Pain; Cardiovascular Complication

Summary: this cross-sectional prospective study will assess the potential association of more severe sleep apnea after spinal cord injury with more intense neuropathic pain, more severe spasticity, and more significant cardiovascular abnormalities including cardiac arrhythmias and blood pressure fluctuations. in addition, the participants' experience when undergoing home-based sleep screening test or hospital-unattended sleep screening test will be assessed in a semi-structured interview.

this cross-sectional prospective study will assess the potential association of more severe sleep apnea after spinal cord injury with more intense neuropathic pain, more severe spasticity, and more significant cardiovascular abnormalities including cardiac arrhythmias and blood pressure fluctuations. in addition, the participants' experience when undergoing home-based sleep screening test or hospital-unattended sleep screening test will be assessed in a semi-structured interview (qualitative analysis).

Eligibility criteria:
inclusion criteria: * individuals with subacute/chronic (\> 1 month after injury) spinal cord injury. * individuals with a mid-cervical/mid-thoracic (levels c5 to t6) spinal cord injury. * individuals with a complete or incomplete (asia impairment scale a, b, c, or d) spinal cord injury. exclusion criteria: * individuals with other disorders of the central nervous system (e.g., sequelae of traumatic brain injury, stroke); * individuals with psychiatric disorders that can interfere with adherence to study; * individuals with neuromuscular diseases; * individuals with history of substance abuse; * individuals with prior history of hypersomnias or sleep apnea under treatment; * individuals with prior history of chronic pain (e.g. fibromyalgia).
music program for hong kong adolescents: improving emotion regulation and reducing depression, anxiety, and loneliness

Conditions: Emotion Regulation; Depressive Symptoms; Anxiety; Loneliness

Summary: this study is a clinical trial that aims to test and validate a music-based program called "tuned in" in helping adolescents in hong kong improve their mental well-being. the researchers want to find out if the program can help participants enhance their ability to regulate their emotions, reduce mood symptoms and feelings of loneliness. participants in the study will be randomly assigned to either the group that receives the program right away (intervention group) or the group that waits for four weeks before receiving the program (wait list group). they will take part in a group-based weekly program for four weeks. additionally, they will be asked to complete questionnaires before and after the program to see if there are any changes in their mental well-being. the program will be delivered by a facilitator with a psychology background, and a registered music therapist. by addressing the gaps in mental health interventions for young people in hong kong, this study aims to contribute to the development of effective strategies to support their emotional well-being.


Eligibility criteria:
inclusion criteria: * self-report as having problems with low mood, anxiety or loneliness * score 3 or above on the general health questionnaire (ghq-12), which indicates psychological distress.

Keywords: adolescence youth emotion regulation music loneliness mental health psychoeducation