Kornimate/medical-research-clean huggingface dataset:
subcongestion in heart failure registry

Conditions: Heart Failure; Congestion

Summary: the goal of this observational study is to learn about the decongestion process in heart failure patients. the main question it aims to answer is: what is the behavior of congestion during hospitalization in adult patients with acute heart failure (ahf)? participants will be evaluated in the decongestion process through clinical, analytical, and ultrasonographic variables, and they will be followed up for one year to assess mortality and rehospitalization rates in this population.

heart failure (hf) is a syndrome characterized by the presence of dyspnea, lower extremity edema, orthopnea, jugular venous distention, and pulmonary crackles, among others, secondary to elevated ventricular filling pressures. it is the leading cause of hospitalization in medical services in chile and worldwide, with the majority of patients being elderly. decompensation of hf is explained in most cases by fluid overload (congestion) and can be studied through biomarkers, clinical signs, radiographic, and ultrasonographic findings. the chilean demographic transition makes it necessary to optimize the multiparametric and protocolized management of hospitalized patients. general objective: to evaluate and describe the decongestion process, including residual congestion, during hospitalization for heart failure at the clinical hospital of the university of chile (hcuch). a prospective observational cohort study will be conducted with all patients hospitalized for heart failure at hcuch. clinical, analytical, and ultrasonographic variables, especially those related to congestion assessment, will be recorded. enrollment will last for one year from institutional authorization, and telephone follow-up will be conducted for one year post-discharge, extendable up to five year.

Eligibility criteria:
inclusion criteria: * adults diagnosed with decompensated heart failure in the emergency department or cardiology outpatient clinic at the clinical hospital of the university of chile (hcuch). * profile of warm-wet and cold-wet type heart failure. * spontaneous ventilation with or without non-invasive mechanical support. * desire for participation validated through informed consent. exclusion criteria: * dry-type heart failure profile (warm and cold) * diagnostics that mimics heart failure (valvular heart disease, cardiomyopathies, and others diagnostic different from heart failure). * septic, distributive, or obstructive shock * polytraumatized * severe burns * invasive mechanical ventilation * permanent renal replacement therapy * severe dependence * presence of terminal illness with a prognosis of survival less than one year * presence of traumatic conditions that prevent the use of thoracic ultrasound, such as a flail chest or moderate to severe burn on the left hemithorax. * lack of a support network or contact. * cardiorespiratory arrest * refusal to participate as indicated in the informed consent. * presence of psychological or intellectual disability that prevents expressing the will to participate.
effect of neuromodulation on pain biomarkers and functional outcome in patients with fibromyalgia syndrome

Conditions: Fibromyalgia Syndrome

Summary: fibromyalgia is the third most common musculoskeletal condition in terms of prevalence, after lumbar pain and osteoarthritis. its prevalence is around 2-4 % and is more frequent in women than in men; the prevalence is highest in age the range of 40-60 years.

group a (control group): patients will receive exercises, and sham non-invasive neuromodulation, 3 sessions per week (one hour for each session) for 4 weeks. group b (study group): patients will receive exercises as in group (a) in addition to non-invasive neuromodulation 3 sessions per week (one hour for each session) for 4 weeks.

Eligibility criteria:
inclusion criteria: 1. patients fibromyalgia from both genders. 2. the duration of fibromyalgia is more than 6 month (all patients with history of cervical or lumbar pain) and following diagnosis of fm using the 2016 revised fm criteria, on the basis of the acr-2010 criteria. 3. their ages will be ranged from 25-35 years old. 4. they will be medically stable and have sufficient cognitive abilities that enable them to understand and follow instruction according to montreal cognitive assessment (moca) \>26. exclusion criteria: 1. other neurological diseases as stroke , multiple sclerosis, parkinson's disease and motor neuron disease 2. pacemaker 3. spinal fusion-cervical or lumbar 4. metal implants in the spine 5. pregnancy 6. epilepsy 7. severe psychiatric disorder or alcohol and drug abuse. 8. unstable medical condition which could compromise the participant's welfare or confound the study results. 9. uncontrolled blood pressure or diabetes 10. visual or auditory problems. 11. active inflammatory conditions

Keywords: fibromyalgia neuromodulation centralization pain biomarkers functional outcome
registration and treatment of pain during eye examination of prematurity

Conditions: Infant, Premature; Retinopathy

Summary: the aim of this study is to see if paracetamol has a pain-relieving effect during eye examination in premature infants.

retinopathy of prematurity (rop) is a feared complication of premature birth. if discovered in time, the disease can be treated, and impaired vision or blindness can be reduced. premature infants are therefore examined regularly after birth. however, the examination is painful and stressful for the infant. painful experiences might lead to a pathological stress response later in life and should therefore be prevented. this is a double blinded, controlled and randomized study where the infants are examined and assessed either with or without the use of paracetamol.

Eligibility criteria:
inclusion criteria: * infants \< 32 weeks of gestational age (\< 31+6 weeks) exclusion criteria: * infants with ongoing analgesic treatment

Keywords: prematurity retinopathy pain acetaminophen
effect of tramadol on postoperative sore throat after general anesthesia

Conditions: Post-operative Sore Throat; Intubation Intratracheal; Thyroid Surgery

Summary: post operative sore throat after general anesthesia with endotracheal intubation is a common problem causing dissatisfaction and discomfort to the patients. the investigators want to study the effect of tramadol on postoperative sore throat in general anesthesia with endotracheal intubation.

design: a prospective, randomized, controlled study. setting: single-center university hospital. participants: the study included 168 patients undergoing thyroid surgery under general anesthesia with endotracheal intubation. interventions: the patients were allocated randomly into the following 3 groups: the control group: patients will be injected intravenously 5ml of normal saline 15 minutes before anesthesia and another 5ml of normal saline was injected intravenously when the incision was washed and sutured；the pre-tramadol group: patients will be injected intravenously 5ml of tramadol (1mg / kg) 15 minutes before anesthesia and 5ml of normal saline was injected intravenously when the incision was washed and sutured. the post-tramadol group: patients will be injected intravenously 5ml of normal saline 15 minutes before anesthesia and 5ml of tramadol (1mg / kg) was injected intravenously when the incision was washed and sutured. postoperatively, all patients will receive standard treatment.

Eligibility criteria:
inclusion criteria: - female with american society of anesthesiologists (asa) physical status i-ii; elective thyroidectomy(non-endoscopic) with endotracheal intubation; the patient signed the consent form. exclusion criteria: - history of thyroid surgery a history of preoperative sore throat; pregnancy; retrosternal goiter; thyroid tumor invading trachea need trachea reconstruction; potentially difficult airway; clinical diagnosis of chronic sore throat; clinical diagnosis of psychosis; tracheotomy after operation； transfer to intensive care unit after operation； contraindications to tramadol； body mass index (bmi) \> 30kg/m\^2.

Keywords: tramadol post-operative sore throat intubation, intratracheal thyroid surgery
safety and efficacy study of bimosiamose cream to treat psoriasis

Conditions: Psoriasis

Summary: the purpose of this study is to determine whether bimosiamose cream is safe and effective in the treatment of plaque type psoriasis.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of plaque type psoriasis pasi score of 5-15 * at least 18 years of age * written informed consent exclusion criteria: * active skin infection * more than 20% body surface area (bsa) affected by psoriasis * use of certain anti-psoriasis medication or treatments
self-help internet-based relapse prevention for problematic alcohol use

Conditions: Problematic Alcohol Use

Summary: the purpose of this study is to observe and evaluate the use of a relapse prevention program over time among internet help-seekers. participants are recruited via a nationally known portal for assisting anonymous individuals with changing their problematic alcohol use in a healthier direction (alkoholhjalpen.se). the intervention offered lasts 10 weeks and includes 7 relapse prevention modules, with a three-week pause between the 6th and 7th modules. baseline data are collected regarding substance use and psychosocial health and follow-up takes place 10 weeks after recruitment. the study is observational.


Eligibility criteria:
inclusion criteria: * audit \>5 points for women * audit \>7 points for men exclusion criteria: * audit \<6 points for women * audit \<8 points for men
outcomes in ovarian cancer and fallopian tube cancer patients using complementary alternative medicine

Conditions: Ovarian Cancer; Peritoneal Primary Cancer; Fallopian Tube Cancer

Summary: rationale: chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. hypnosis, massage therapy, and healing touch may improve the quality of life of patients who are undergoing chemotherapy. purpose: this randomized clinical trial is studying how well giving hypnosis, massage therapy and healing touch changes outcomes in women receiving chemotherapy for newly diagnosed epithelial ovarian, fallopian tube or peritoneal cavity cancer.

objectives: primary * determine whether quality of life is improved in patients with epithelial ovarian, fallopian tube or primary peritoneal cavity cancer receiving hypnosis, massage therapy, and healing touch and standard chemotherapy as compared to patients receiving standard chemotherapy alone. secondary * determine changes in immunologic response markers, chemotherapy side effects, and complication rates in these patients. outline: this is a randomized study. patients are randomized to 1 of 2 treatment arms. * arm i (standard therapy): patients undergo standard chemotherapy for epithelial ovarian, fallopian tube or primary peritoneal cancer. * arm ii (standard therapy with complementary alternative medicine): patients undergo chemotherapy as in arm i. patients also undergo massage over approximately 30 minutes and healing touch therapy over approximately 30 minutes with each course of chemotherapy 1-6 and hypnosis over 30-60 minutes during courses 1, 2, and 4. quality of life is assessed at baseline, during courses 3 and 6 of chemotherapy, and then 6 months after completion of study treatment. after completion of study treatment, patients are followed at 6 months.

Eligibility criteria:
inclusion criteria: * newly diagnosed epithelial ovarian, primary peritoneal or fallopian tube cancer, any pathologic type or stage, who will receive 6 cycles of chemotherapy. * patients must have signed an informed consent exclusion criteria: * previous cancer other than skin cancer * previous chemotherapy experience * active substance abuse * schizophrenia * pregnant or lactating

Keywords: stage i ovarian epithelial cancer stage ii ovarian epithelial cancer stage iii ovarian epithelial cancer stage iv ovarian epithelial cancer peritoneal cavity cancer
digoxin versus ivabradine in heart failure with preserved systolic function

Conditions: Heart Failure; Atrial Fibrillation

Summary: this is an investigator-started study. the trial is coded as no. gc\&pj-dig-iva2009-2012. the authors have no conflict of interest and there was no financial sponsoring the study was planned according to the good clinical quality standards using an intention-to-treat analysis. the protocol was approved from the ethics committee. selected patients gave their written informed consent. the family practitioners agreed and obtained the collected data and analysis. analysis of collected data was performed by a single-blinded author (without knowledge of the used test drug and time of collection of data). study hypothesis: compare the effect of digoxin and ivabradine in chronic heart failure with permanent atrial fibrillation (ischemic etiology). multiple time frames: primary outcome is measured before and after each medical intervention. measurements at baseline and after 3 month of therapy (twice, with the 2 different drugs): measurements severity of dyspnea. digoxin serum concentration. ecg: heart rate at rest and during 6-min walking test. cardiac function (echocardiography): systolic function (ejection rate, left trial size,diastolic function. participants were followed (ambulatory observation) for at least 3 months

selected patients had chronic coronary artery disease which had been treated with percutaneous dilatation \& stenting and/or aortocoronary bypass. the severity of myocardial ischemia had induced heart failure with diastolic dysfunction and preserved systolic function, and permanent af. 1 inclusion criteria: dyspnea class iii nyha. abnormal left ventricular relaxation with preserved (≥52%) ejection fraction (lvef). patients either in sinus rhythm or with permanent atrial fibrillation. 2. exclusion criteria: unstable angina pectoris. reduced systolic cardiac function (lvef\<52%). normal diastolic function. diabetes requiring insulin. moderate or severe renal or hepatic dysfunction. technically insufficient echocardiography.

Eligibility criteria:
inclusion criteria: no need to change concomitant pharmacological therapy in the following months, dyspnea class iii nyha, and abnormal left ventricular relaxation with preserved (≥52%) left ventricular ejection fraction (lvef). exclusion criteria: unstable myocardial ischemia, reduced systolic cardiac function (lvef\<52%), diabetes mellitus requiring insulin, moderate or severe renal or hepatic dysfunction, or technically insufficient echocardiography.

Keywords: digoxin ivabradine cardiac failure economics
rheumatoid arthritis-associated interstitial lung disease definition

Conditions: Rheumatoid Arthritis-Associated Interstitial Lung Disease

Summary: this is a prospective multicenter study in southern belgium to determine the prevalence and incidence of interstitial lung disease in patients with rheumatoid arthritis (ra).

this is a prospective multi-centric longitudinal study of the prevalence and incidence of pulmonary diseases in patients with ra. during one year, patients with a ra diagnosis (according to the criteria of the american society of rheumatology) in the south of belgium will be enrolled on a voluntary basis. if available, data including quality of life and symptoms questionnaires, medical examinations, 6-minute walk-tests, pulmonary function tests and chest ct will be collected during two years. furthermore, patients could be included (if available data) in two additional sub-cohorts: * "raidbio" sub-cohort studying biomarkers: volatile organic compounds, induced sputum and blood biomarkers; * "raidomix" sub-cohort studying radiomic patterns (based on high resolution computed tomography of the chest). due to a non-specific and poor clinical expression at beginning, there is currently an under-diagnosis of rheumatoid arthritis associated-interstitial lung disease (ra-ild) at an early stage and we assume that an annual pneumological follow-up, search of early biomarkers and a radiomic approach of ra patients will overcome this issue. this should lead to a better follow-up and management (including the use of anti-fibrotic therapies in the future) of these patients and ultimately to a decrease in morbidity and mortality.

Eligibility criteria:
inclusion criteria: * diagnosis of rheumatoid arthritis according to the criteria of the american society of rheumatology * age \> 18 years * willing to participate in the study and sign the informed consent form (icf) of participants or their legal authorized representative * raidbio subcohort : available data for one of the following analysis of biomarkers: volatile organic compounds, induced sputum or blood markers * raidomix : available data for high resolution computed tomography of the chest exclusion criteria: none

Keywords: rheumatoid arthritis rheumatoid arthritis-associated interstitial lung disease interstitial lung disease
community-based peer facilitator intervention (zimbabwe)

Conditions: HIV-infection/Aids

Summary: the goal of this community randomized operations research study was to evaluate the effect of a peer-facilitated community support group intervention on uptake of maternal and neonatal child health (mnch) and pmtct services and on adherence outcomes in zimbabwe.

to increase uptake of, and retention within maternal and child health/prevention of maternal-to-child hiv transmission (mch/pmtct) services, the investigators conducted a community-based peer facilitator intervention study in hurungwe district of zimbabwe. using a paired community randomized design, 16 health facility-linked communities were randomly allocated to the intervention or control condition, with a total of approximately 1,600 pregnant and lactating women, (100 women in each community), recruited into the study. in the intervention communities, 24 trained peer facilitators (3 in each community) using participatory educational approaches were encouraging women to form antenatal and post-natal groups, and to utilize and adhere to mch/pmtct services and recommendations. peer facilitators, by the definition of this project, were women from the community who were peers to pregnant and lactating women; who had recently been through the process themselves and could speak to their experience. a key activity of the community-based peer facilitators was the encouragement of the formation of women into groups, and the participation of these women into antenatal care (anc), prevention of maternal to child transmission (pmtct), and postnatal care (pnc) programs. the group process was enable solidarity and support among the women at the vulnerable times of pregnancy and lactation.

Eligibility criteria:
inclusion criteria: * pregnant and breastfeeding women who were 18 years of age and above, regardless of hiv status, were eligible to participate in support groups. exclusion criteria: * women less than 18 years and those who were mentally ill were excluded as they could not give informed consent.
enumeration and molecular characterization of circulating tumour cells in women with metastatic breast cancer

Conditions: Metastatic Breast Cancer

Summary: women with metastatic breast cancer, receiving first line treatment of any kind (chemotherapy, endocrine treatment or treatment with antibodies) will be included in this trial. in connection to treatment, blood samples for determination and enumeration of circulating tumour cells will be collected at different time points. serum and plasma will be collected and stored for future analysis of rna and dna.


Eligibility criteria:
inclusion criteria: * women with metastatic breast cancer * ecog performance status 0-2 * age over18 years * signed informed concent * predicted life expectancy over 2 months * planned for first line systemic treatment for metastatic disease (chemotherapy, antibody treatment or endocrine treatment) * standard imaging evaluation within 4 weeks of inclusion * planned for standard imaging within 16 weeks after start of therapy exclusion criteria: * prior medical therapy for metastatic disease (prior adjuvant chemotherapy, radiotherapy or endocrine therapy is permitted) * inability to understand information about the study * other malignant disease with the exception of curatively treated basal cell or squamous cell cancer of the skin and cancer in situ of the cervix

Keywords: metastatic breast cancer circulating tumour cells ctc prognostic factors treatment response
methylene blue and microcirculation in septic shock

Conditions: Septic Shock

Summary: this trial aims to identify the effects of methylene blue infusion on the the micro-circulation in patients with septic shock. the investigators will evaluate various indices of micro-circulation such as: microvascular ﬂow index, the flow heterogeneity index, the total vessel density, the perfused vessel density, and the proportion of perfused vessels.

the mortality rate of patients with septic shock remains very high. arterial hypotension, related to arteriolar vasodilation and myocardial depression are the mainstays of septic shock pathology. at the level of the micro-circulation, there is insufficient delivery of oxygen to organs and tissues which results in organ dysfunction and potential organ necrosis.one key factor leading to vascular dysfunction is the inappropriately increased production of nitric oxide within the blood vessel endothelium. elevated levels of nitric oxide results in the blood vessel endothelium receiving direct vasodilator input, as well as the inability to respond to norepinephrine-mediated vasoconstriction. nitric oxide activates the soluble isoform of the enzyme guanylatecyclase, which in turn increases production of cyclic guanosine monophosphate. nitric oxide has other beneficial effects which are mediated via other pathways than guanylatecyclase; therefore, administration of a guanylate cyclase inhibitor such as methylene blue could be a safer therapeutic option than the inhibition of nitric oxide production. these effects of methylene blue could be related to vasoconstriction and positive inotropic effects as well to an increase in blood volume, itself related to a decrease in vascular permeability. the use of methylene blue has been recently advocated as a potential adjunct in the treatment of shock states. however, the effect of mb at the level of the capillary bed, where vital exchange of oxygen and nutrients occurs, is unknown. thus in this study, the investigators will investigate the effect of methylene blue in combination with ne at the microvascular level in septic shock.

Eligibility criteria:
inclusion criteria: * septic shock * the patient is on norepinephrine infusion exclusion criteria: * elevated serum creatinine (above 1.4 mg/dl) * pregnancy
long-term follow-up after hiatal hernia repair by tension-free mesh closure or simple suturing

Conditions: GERD; Hiatal Hernia; Dysphagia, Esophageal; Quality of Life

Summary: 10 years of follow-up after surgery for hiatal hernia by tension-free mesh closure or simple suturing.

one-hundred and fifty-nine patients undergoing nissen fundoplication for symptomatic gastro-oesophageal reflux disease (gord), who had a concomitant hiatal hernia of \> 2 cm axial length, were previously randomized to closure of the diaphragmatic hiatus with either crural sutures alone or tension-free closure with a non-absorbable mesh. primary outcome variable was the incidence of radiologically verified recurrent hiatal hernia 3 years after the surgery and secondary outcomes were dysphagia score, reflux control and quality of life. the study showed no differences between the groups regarding hiatal hernia recurrence but higher dysphagia scores for solid food at 3 years in mesh group. this study is a long-term follow-up (\>10 years) after surgery for hiatal hernia by tension-free mesh closure or simple suturing.

Eligibility criteria:
inclusion criteria: -patients available at the time of follow-up exclusion criteria: * deceased * declined participation