Kornimate/medical-research-clean huggingface dataset:
implementation of internet-based cognitive behaviour therapy for adolescents with co-morbid insomnia

Conditions: Insomnia

Summary: insomnia is a commonly reported comorbidity for adolescents with psychiatric conditions. it is well-known that insomnia can exacerbate the concurrent psychiatric symptom load. results from a pilot study shows that outpatients of children and youth psychiatry can improve their sleep and depressive symptoms by receiving internet-based cognitive behavioral therapy for insomnia (icbt). this study is designed to evaluate implementation of the treatment in routine care.the study will evaluate aspects of the implementation process such as organizational attitudes towards icbt before implementation, level of knowledge about the condition and intervention among health-care providers before and after the implementation, and clinical outcomes in routine care.


Eligibility criteria:
inclusion criteria: * to fulfill the diagnostic criteria for insomnia * to have access to a computer with internet connection * no previous or ongoing cbt for insomnia exclusion criteria: * ongoing manic or psychotic episode * being at high risk of triggering manic or psychotic episode * ongoing sleep apnea
study of memantine augmentation in severe obsessive-compulsive disorder

Conditions: Obsessive-Compulsive Disorder

Summary: memantine is a glutamate receptor antagonist that has been reported to reduce obsessive-compulsive disorder (ocd) symptoms in case studies of treatment-resistant individuals. the investigators hypothesized that memantine is an effective augmenting agent to standard intensive residential treatment of severe ocd. an intent-to-treat, single-blinded, naturalistic case-control design is employed. the sample includes subjects receiving standard treatment at the mclean/ mgh intensive residential treatment (irt) program, half of whom also receive memantine augmentation. admission, monthly and discharge measures of ocd, depression and psychosocial functioning are collected by raters blinded to augmentation status. matched controls are selected based upon gender, initial ocd severity, psychosocial functioning, and timing of admission. descriptive and comparative analyses are conducted via spss, statistical significance is defined at p\<0.05, clinically significant response is defined by a 25% reduction, and 'marked response' is defined by a 50% improvement in yale-brown obsessive compulsive severity (y-bocs) scores, using a last-observation-carried-forward approach. the clinical global improvement (cgi) scale captures global clinical change.


Eligibility criteria:
inclusion criteria: * consecutive patients of irt at the ocd institute who agreed to augmentation with memantine. * consecutive patients of irt at the ocd institute who were not offered augmentation with memantine and who were matched according to ocd severity, gender, and psychosocial functioning. exclusion criteria: * subjects offered memantine augmentation who did not provide voluntary consent.

Keywords: to evaluate the effectiveness of memantine as an augmenting agent for standard intensive residential treatment of severe obsessive-compulsive disorder (ocd)
investigation of square step exercise applied by telerehabilitation in chronic obstructive pulmonary disease patients

Conditions: COPD; Cognitive Impairment; Balance; Distorted

Summary: copd is a progressive disease associated with systemic inflammation, with many extrapulmonary outcomes such as cognitive impairment. most of the daily activities involve doing several tasks at the same time, such as walking while talking or avoiding obstacles.

the most prominent independent risk factor for cognitive impairment in copd patients is reduced oxygen availability as a result of lung dysfunction. the prevalence of cognitive impairment in copd patients ranges from 10% to 61%. a wide variety of tools have been developed for screening cognitive functions. the most widely used tests covering multiple cognitive domains are the mini mental state examination (mmse) and the montreal cognitive assessment (moca). when two tasks are performed at the same time, they compete for sources of attention, resulting in decreased performance on one or two tasks. balance or postural control is a complex skill required for independent mobility and preventing falls. balance performance naturally decreases with age; however, certain conditions are associated with more pronounced and rapid declines. balance problems and fall risk are increased in copd patients.from this perspective aim of this study is to assess the effect of square-step exercise and strengthening exercise applied with telerehabilitation on cognitive status and balance in patients with copd.

Eligibility criteria:
inclusion criteria: * being diagnosed with mild / moderate copd by bolu abant izzet baysal university faculty of medicine, department of chest diseases. * mini mental score is 23 or higher * being between the ages of 50-80 * spirometric evaluation result is forced expiratory volume at one second / forced vital capacity \<70% and airflow restriction is 50% forced expiratory volume at one second \<80% (expected) degree compared to post-bronchodilator forced expiratory volume at one second. * no drug change or antibiotic use due to acute exacerbation for at least three weeks exclusion criteria: * individuals who need continuous oxygen support * individuals with partial pressure of carbon dioxide≥70 mmhg * having a history of uncontrolled illness that may affect cognitive skills * have uncorrected vision and hearing impairment * having kyphoscoliosis and/or severe postural impairment * having additional risk factors (stroke, neurological disease, dementia, depression, postural hypotension, diaphragm dysfunction)
scapulo-thoracic mobilization compared to iastm in patients with mechanical neck pain

Conditions: Mechanical Neck Pain

Summary: scapulo-thoracic mobilization compared to iastm in patients with mechanical neck pain

mechanical neck pain is common musculoskeletal condition that causes work disabilities and is not self-limiting. one of the main causes for mechanical neck pain is forward head posture, which is common and but not ideal posture adopted by many workers and students who presents with head being anterior to the shoulder. imbalances in the normal muscle function reported in such patients with inhibited deep neck flexors, serratus anterior and rhomboids and tightened pectoralis, upper trapezius and levator scapula. neck and scapula have some common muscle attachments and abnormal loads on cervical or thoracic spine change the biomechanics of muscles present in these regions, which eventually cause trigger points management of scapulo-thoracic joint focuses on correcting posture, restoring flexibility of the scapula including the pectoralis minor, levator scapulae, rhomboids, mobilization and soft tissue techniques. iastm is ergonomically designed stainless steel tool, and has recently gained much popularity for elevating pain, reducing trigger points and improving roms because it has deeply penetrating power as compared to mobilization through hand. this technique works by both along the mobilizing muscle fibers or parallel to the muscle fibers.

Eligibility criteria:
inclusion criteria: * age group 18 to 40 years * both gender groups * non radiating neck pain exclusion criteria: * history of cervical and thoracic spine surgery * vertibro-basilar insufficiency * sign of serious pathology like malignancy * signs of systemic inflammatory disorder * patient with diagnosed hypertension * (scapular area pathology)

Keywords: iastm scapulo-thoracic mobilization mechanical neck pain
online mind/body program for fertility

Conditions: Infertility

Summary: this pilot-study assesses the feasibility and acceptability of an online mind/body fertility program, designed to help individuals and/or couples cope with the physical and emotional impact of infertility by learning special relaxation strategies and improving lifestyle habits. participants included women experiencing infertility who had not given birth to a child. half of participants received access to the 10-week online mind-body program and the other half were placed on a waiting-list.

infertility is defined as the inability to conceive a child. a couple may be acknowledged as infertile if conception has not occurred after 12 months of having regular, unprotected intercourse. over six million couples in the united states are affected by infertility. research suggests that there is a relationship between psychological distress and infertility, but the relationship is complex. the information from this study will be used to better understand the relationship between psychological distress and infertility among couples. furthermore, the investigators are interested in testing dr. alice domar's mind/body fertility program that was designed to help individuals regain control of their life and learn new lifestyle habits that can increase their chances of conceiving. there is evidence that individuals that participated in the group format of this treatment protocol showed statistically significant decreases in physical and psychological symptoms of stress and increases in conception rates. our primary goals are to evaluate patients willingness to be recruited and randomized as well as their adherence and attrition to the program. our secondary goals are to evaluate reductions in emotional distress (i.e., anxiety, depression, and stress) and enhance emotion regulation skills as well as pregnancy rates.

Eligibility criteria:
inclusion criteria: * women and men * infertility diagnosis * trying to get pregnant * 18 years or older * read and write english exclusion criteria: * no current diagnosis for an active psychotic disorder, eating disorder, substance abuse or dependence * not reporting current suicidal ideation/intent * no psychotropic medication changes in the last four weeks * has not completed a formal mind/body program focused on infertility that included relaxation, yoga, mindfulness, cognitive restructuring, stress reduction strategies, listening and communication skills, goal setting and assertiveness training.

Keywords: mind/body
quality of life in patients undergoing total pelvic exenteration

Conditions: Total Exenteration; Anterior or Posterior Pelvic Exenteration; Gynecologic Malignancies; Colorectal Malignancies; Urologic Malignancies

Summary: the purpose of this study is to learn more about the personal experiences of patients who are treated with pelvic exenteration surgery. pelvic exenteration is a surgical procedure in which the pelvic organs including the reproductive organs, bladder and/or rectum are removed. we would like to understand more about the physical, emotional, educational, and sexual needs of patients who are treated with this surgery. we will use what we learn from this study to help find better ways of preparing patients for this type of surgery. this will also allow us to be more helpful to patients' needs after surgery.

this protocol represents the first study to comprehensively evaluate qol in a mixed population of male and female patients treated with total, anterior or posterior pelvic exenteration. this unique approach to qol assessment which is both domain-centered and able to emphasize individual differences through the c-ship model has the potential to set the standard for evaluating qol in patients who undergo extensive pelvic surgery. the longitudinal design of this study facilitates the documentation of patients'responsiveness to change. by analyzing participants' responses at intervals we will be able to document the redefinition of life goals which occurs as patients adapt to their new health status. the data and analysis completed in first three years of this study will be used to generate further hypotheses for future investigation.

Eligibility criteria:
inclusion criteria: * all patients (male and female) who are scheduled to undergo total, anterior or posterior pelvic exenteration for pelvic malignancies arising in gynecologic, colorectal or urologic organs are eligible for participation in the study. anterior or posterior pelvic exenteration must involve formation of a permanent ostomy (urostomy or colostomy). * participants must be able to speak and read english proficiently. * participants must be able to provide written informed consent. * patients must be 18 years of age or older to enroll. exclusion criteria: * subjects may be excluded or withdrawn from the study based on the following criteria. * development of a cognitive or psychiatric deficit resulting in an inability to provide meaningful informed consent * inability to speak or read in english.
flexible attention sensory training for youth with chronic pain

Conditions: Persistent Pain

Summary: the purpose of this study is to determine the feasibility and acceptability of gamified sensory rehabilitation training technology for children with chronic musculoskeletal pain.

the trainpain devices allows patients with chronic pain to perform sensory rehabilitation training at home, in a gamified format. the system uses a temporary tactile discrimination task, which directly engages inhibitory functions of the somatosensory cortex. in this way, the game trains the brain's sensory system to be more precise. the technology's dual-probe system allows sensory stimuli to be delivered to multiple body locations, which trains patients to flexibly shift their attention towards and away from pain according to dynamic game-directed goals. the sensory training reduces hypervigilance towards painful body regions and enables flexible attention shifting to engage with daily goals. last, the trainpain system captures and quantifies performance over time, providing a breadth of intricate and precise data, thus allowing the research team to assess outcomes and mechanisms of training effects. in preliminary studies with adults, trainpain is shown to be highly engaging, and effective at reducing pain in adults with widespread musculoskeletal (msk) pain. the current pilot study intends to establish, for the first time, the feasibility and acceptability of using the trainpain system among youth with chronic msk pain.

Eligibility criteria:
inclusion criteria: * diagnosis of musculoskeletal pain including chronic regional pain syndrome * english speaking exclusion criteria: * diagnosis of neurological conditions such as seizures, cerebral palsy, developmental delay * severe affect disorders (e.g. severe depression/anxiety) from medical record review * chronic skin disease or topical allergies that would be worsened by the use of sensor tape
the efficacy and safety of carto 3d mapping system versus conventional method in af and vt

Conditions: Atrial Fibrillation

Summary: the purpose of this study is to evaluate the efficacy and safety of electroanatomic imaging compared to conventional method in patients with vt.

to evaluate the efficacy and safety of electroanatomic imaging (carto) compared to conventional fluoroscopically guided activation mapping (conventional) method in patients with atrial fibrillation and substrate-dependent ventricular tachycardia to evaluate cost-effectiveness of carto 3d image system compared to conventional method in the same study subjects

Eligibility criteria:
inclusion criteria: * patients with af or substrate-dependent vt exclusion criteria: * administering with anticoagulants
tdi preejection velocities and myocardial viability

Conditions: Coronary Artery Disease

Summary: the purpose of the study is to test accuracy of positive preejection velocity to predict left ventricular remodeling and long-term prognosis after revascularization in 200 patients with chronically dysfunctional myocardium. patients will be followed for 3 years. our hypothesis is that tissue-doppler-derived analysis of positive preejection velocity allows to select optimal responders to revascularization; it means individuals with the greatest benefit in terms of lv remodeling and long-term prognosis.

the objective of the project is to study clinical and prognostic value of new echocardiographic technique, so called positive preejection velocity (+vic), in patients with chronic ischemic left ventricular (lv) dysfunction indicated for revascularization. pilot studies has shown high accuracy of pulsed tissue doppler imaging (tdi)-derived resting pattern of +vic to detect viable myocardium in patients with both acute myocardial infarction and chronically dysfunctional myocardium. the aim of the project is to test accuracy of +vic to predict lv remodeling and long-term prognosis after revascularization in patients with chronically dysfunctional myocardium. study population will consist of two groups of patients with stable ischemic lv dysfunction: group a- patients indicated for revascularization (n=200), group b- matched control group treated conservatively (case-control design) (n=100). all patients will be followed for 3 years. endpoints include: 1) lv remodeling at 6 and 24 months and 2) mace at 6, 12 and 36 months follow-up. our hypothesis is that tdi-derived analysis of +vic allows to select optimal responders to revascularization; it means individuals with the greatest benefit in terms of lv remodeling and long-term prognosis.

Eligibility criteria:
inclusion criteria: 1. occluded or suboccluded left anterior descending coronary artery (lad) at recent coronary angiography (\< 3 months); 2. lv ejection fraction \< 40%; 3. 3 and more akinetic or severely hypokinetic segments in the lad perfusion territory at resting echocardiography. exclusion criteria: - patients with recent acute coronary syndrome, atrial fibrillation, bundle branch block, lv hypertrophy or aneurysm, significant valvular disease, pacemakers or internal defibrillators, poor echocardiographic image quality and contraindications for mri are excluded.

Keywords: viability myocardium preejection velocity cad echocardiography tissue doppler
a quality of life study in patients with migraines

Conditions: Migraine; Headache; Depression

Summary: the purpose of this study is to compare depressive characteristics in migraine patients to those observed in patients with epilepsy in a previous study, and determine whether those symptoms are unique to patients with epilepsy.

a form of depression known as dysphoric-like disorder is common in people with epilepsy, which may significantly affect the quality of life in these people, as shown in a previous study. however, it is unclear if this depressive disorder is unique to patients with epilepsy. in order to assess whether these symptoms are unique and idiosyncratic to the epilepsy population, in this multi-center study, these dysphoric depressive features will be contrasted to those seen in patients with other neurologic or psychiatric conditions. migraine is selected as one of the comparison disorders because it shares with epilepsy characteristics of being a recurrent episodic central nervous system disorder, and our site will only enroll patients with migraine headaches.

Eligibility criteria:
inclusion criteria: * male or female 18 years of age or older * have the diagnosis of migraine * have had no change in migraine medication(s) 30 days prior to study * achieve a satisfactory score on the wide range achievement test 3 (wrat3) test at the screening visit * capable of completing self-reporting questionnaires * willing and able to provide written informed consent and comply with the study protocol exclusion criteria: * presence of a clinically significant comorbidity of an unstable or progressive nature * presence of major depression * participation in an investigational drug study within the past 30 days * inability to communicate well with site study personnel

Keywords: migraine headache depression quality of life
knee functionality recovery indicators in athletes submitted to ligamentoplasty of the anterior cruciate ligament

Conditions: Ligament Injury; Ligament Rupture; Ligament Disorders

Summary: anterior cruciate ligament (acl) injuries are recurrent, especially in sports. there is still no consensus on the characterization of functional indicators in this clinical condition, as well as their correlation with measuring instruments and clinical functional tests. it is intended to study the changes in functionality of users undergoing this surgery, aiming with functional assessment scales at different times of recovery. this will allow deciding on more adapted recovery strategies, which can meet the musculoskeletal requirements of the user.

it is proposed to carry by carrying out quasi-experimental, quantitative and analytical studies. the sample will consist of athletes who have started recovering from acl surgery and who meet the previously established inclusion and exclusion criteria. the study will use and compare functional tests (star excursion balance test, lateral step down test and weight-bearing lunge test) with measurement instruments: knee and osteoarthritis outcome score (koos), lyshom knee scoring scale, lower extremity functional score (lefs), return to sport after injury scale (acl-rsi) and ikdc subjective knee evaluation form. the intervention will be performed on individual athletes who have had anterior cruciate ligament injury for the first time or recurrence of this ligament in the same knee or injury in the contralateral knee.

Eligibility criteria:
inclusion criteria: * start of physiotherapy in the preoperative context and continuation of recovery up to 2 weeks after surgery; age equal to or greater than 18 years; with or without meniscal injury; be able to correctly fill in the assessment instruments and complete the informed consent form; exclusion criteria: * concomitant bilateral injury/history of surgery or contralateral dysfunction; meniscal suture; cartilaginous injury; injury to the internal lateral ligament, external lateral ligament and posterior cruciate ligament; concomitant intra and extra-articular plastic surgery; individuals with recent heart disease, intermittent claudication, neuropathies and cognitive alterations.

Keywords: ligament injury preoperative postoperative functional tests
bempedoic acid + ezetimibe fixed-dose combination (fdc) study in patients with type 2 diabetes and elevated ldl-c

Conditions: Diabetes; Diabetes Mellitus, Type 2; Cholesterolemia

Summary: 12 week study to assess the ldl-c lowering efficacy, other lipid and glycemic measures, and safety of bempedoic acid/ezetimibe fdc compared to ezetimibe and placebo in patients with type 2 diabetes (t2d) and elevated ldl-c

assess efficacy of fdc vs. ezetimibe vs. placebo for 12 week ldl-c lowering, changes in atherogenic lipids, hscrp and exploratory glycemic measures as well as safety in patients with type 2 diabetes and elevated ldl-c.

Eligibility criteria:
inclusion criteria: * type 2 diabetes for 6 months or greater * currently taking stable diabetes medication for 3 months or greater * hba1c between 7-10% * ldl-cholesterol greater than 70 mg/dl * women must not be pregnant, lactating, or planning to become pregnant within 30 days after last dose of study medication; and must be postmenopausal, surgically sterile, or willing to use 1 acceptable form of birth control during the study through 30 days after the last dose of study medication exclusion criteria: * body mass index \> 40 kg/m2 * history of documented clinically significant cardiovascular disease * fasting triglycerides \> 400 mg/dl * history of type 1 diabetes * uncontrolled hypothyroidism, liver dysfunction, renal dysfunction, gastrointestinal condition that may affect drug absorption, hematologic or coagulation disorder or active malignancy * history of drug or alcohol abuse within 2 years

Keywords: diabetes cholesterolemia type 2 diabetes ldl-c t2d diabetes mellitus