Kornimate/medical-research-clean huggingface dataset:
misoprostol in termination of first trimester missed abortion

Conditions: Miscarriage

Summary: the purpose of this study is to determine whether oral versus vaginal misoprostol is effective in termination of first trimester missed abortion and to compare between two different routes.

objective: to compare the effectiveness of oral versus vaginal misoprostol prior to surgical termination of first trimester missed abortion as cervical priming agent , the difference of cervical dilatation immediately prior to operation , the duration of operation and side effects between two treatment groups. design: this study was conducted as randomised study. setting: maternity teaching hospital in hawler/ kurdistan/ iraq. population: over a period of six months from the first of january to the thirtieth of june, 2008, one hundred women were included in this study. they were cases of first trimester abortion (6-12 weeks). method: patients were randomly selected for the type of treatment they received. the first group (oral) were assigned to receive 400 micrograms of misoprostol orally as preoperative cervical priming agent, where as the second group (vaginal) were allocated to have treatment either with vaginal misoprostol to receive 400 micrograms vaginally. main outcome measure: oral versus vaginal misoprostol as cervical ripening agent prior to termination of first trimester missed abortion. keywords: first trimester, missed abortion, misoprostol, cervical ripening, oral, vaginal.

Eligibility criteria:
inclusion criteria: * all patients were cases of first trimester missed abortion. * they have uneventful history apart from history of slight vaginal bleeding, with normal general examination. gynecological examination revealed no vaginal bleeding or discharge with no dilatation of the internal os with enlarged uterus. exclusion criteria: * cases with suspected or proven ectopic pregnancy, history of caesarean section, medical diseases, a known hypersensitivity to a drug, smokers, patients with abnormal results of investigation and the presence of vaginal bleeding were excluded from the study.

Keywords: first trimester missed abortion misoprostol cervical ripening oral vaginal first trimester missed abortion
basel long covid-19 cohort study and digital long covid substudy

Conditions: Post COVID-19 Condition (PCC)

Summary: the basel long covid cohort study (balcos) is a registry-based cohort study that focuses on the patients' present health status, symptoms, the course of these symptoms, and potential mechanisms involved. the project aims to investigate proposed mechanisms behind post covid-19 condition (pcc), including a) autoimmunity, b) chronic inflammation, c) genetics, d) coagulation disorders, and e) psychosocial factors. patients in the cohort can also join the digital long covid study (dilcos), a single-arm, cohort-based proof-of-feasibility study that is part of the larger balcos. dilcos is a intervention substudy designed to evaluate whether doing exercises delivered via a smartphone app (referred as digital intervention) can help with pcc. the digital intervention is a 12-week program that includes different kinds of exercises like breathing exercises, relaxation techniques, and tips on managing fatigue and other symptoms. it also teaches patients how to monitor their activities and energy levels, and provides psychological exercises to cope with negative thoughts and pain. patients in the cohort complete a set of assessments that include the collection of sociodemographic and clinical data, biomarkers, neurocognitive testing, psychometric questionnaires, and measures of physical performance, and provide consent that their data from routine clinical care can be used for the study.


Eligibility criteria:
inclusion criteria: * patients diagnosed with pcc will be included. pcc will be defined as: * history of confirmed or suspected sars cov-2 infection * symptoms usually start within 3 months from the onset of acute sars cov-2 infection with symptoms and effects that last for at least 2 months * symptoms cannot be explained by an alternative diagnosis * signed informed consent is required additional inclusion criteria for participtation in dilcos: * a smartphone with a compartible-operating system * separate signed informed consent is required exclusion criteria: * age \<18 years * lack of consent to participate in the study * language barriers (lack of sufficient knowledge of german) * lack of general understanding of study procedures

Keywords: coronavirus disease (covid) severe acute respiratory syndrome coronavirus 2 (sars-cov-2) somatic symptom disorder (ssd) fatigue shortness of breath cognitive dysfunction
clinical and laboratory characteristics of a population of children and adolescents with newly diagnosed type 1 diabetes and insulin requirements at onset

Conditions: Type 1 Diabetes (T1D)

Summary: the clinical implication of this study lies in the identification of factors that may predict reduced insulin sensitivity in children and adolescents at the onset of type 1 diabetes and would help the physician to undertake appropriate therapy more quickly by achieving the correct therapeutic dosage, in order to achieve good metabolic compensation at an early stage and thus reduce the time (and costs) of hospitalisation.

the primary aim of this observational, retrospective, single-centre, non-pharmacological study is to assess whether the presence of clinical and laboratory predictive factors at the onset of type 1 diabetes may be related to an increased insulin requirement in a population of pediatric and adolescent patients with diagnosis of type 1 diabetes between january 2014 and december 2018 at the pediatrics unit of the irccs azienda ospedaliero-universitaria of bologna, italy. the secondary aim is to assess the insulin requirement 1 year after the onset of type 1 diabetes. this study consists of collection and analyses of clinical and laboratory data of patients enrolled.

Eligibility criteria:
inclusion criteria: * age ≤ 14 years at the time of diagnosis of type 1 diabetes; * diagnosis of type 1 diabetes confirmed between january 2014 and december 2018 at the pediatrics unit of the irccs azienda ospedaliero-universitaria of bologna, italy; * patients with at least 1 year of follow-up after diagnosis od type 1 diabetes; * obtaining informed consent from parents/legal guardian of pediatric patients. exclusion criteria: * patients with diabetes other that type 1; * patients followed at other centres at the time of onset of type 1 diabetes.

Keywords: type 1 diabetes
the effect of thai traditional music on cognitive function, psychological health and quality of sleep among thai older individuals with dementia

Conditions: Cognitive Function; Sleep

Summary: to determine the effect of thai traditional music on cognitive function, psychological health and quality of sleep among thai older individuals with dementia.

dementia, regardless of its cause, has been recognized to be one of the most important and common problems among the elderly worldwide. the prevalence of dementia has been increasing gradually throughout the world. it is associated with medical and psychological consequences, especially in the advanced stage of the condition. medications for dementia, specifically, acetylcholine esterase inhibitors, have proven efficacy but variable individual response. they are very expensive and stress families and insurance payers. dementia and its neuropsychiatric co-morbidities effects not only individual patients, but also family members and care givers as it stresses interpersonal relationships, increases the need for personal care, nursing home placement, and the use of neuropsychiatric medications. any new approach to improve cognitive function, behavior, mood and sleep quality among demented individuals therefore could have far reaching benefits for patients, care givers, financially responsive parties, and the country as a whole. there are several studies focusing on the non-pharmacologic approaches to care of the demented. the objectives were to reduce reliance on prescribed medications with these adjunctive therapies. one of the interesting non-drug trials was about music therapy. it was found that music could improve behavioral and social functions among individual demented patients. however, the methodology of each music study varied considerably. to our knowledge, there has been no music study in dementia performed in thailand using our unique thai traditional music. we therefore aim to study this non-pharmacologic approach in thai demented individuals using thai traditional music. we hypothesized that regular listening to thai traditional music will improve cognitive function, activities of daily living, mood, behavior and sleep quality in thai demented patients.

Eligibility criteria:
inclusion criteria: * age \> 60 years * diagnosed with alzheimer's disease, vascular dementia or mixed dementia by icd-10 * no change in neuropsychiatric drugs for at least 4-week before and 8-week during the study * cd player available at home * patient and care giver consent to study exclusion criteria: * severe depression requiring aggressive treatment or hospitalization * dementia with lewy body, multisystem atrophy * treatable dementia * active medical problems * profound hearing loss

Keywords: thai traditional music dementia cognitive function behavioural problem sleep quality psychological health quality of sleep
faza pet imaging in detecting lymph node metastases in renal cell carcinoma patients

Conditions: Renal Cell Carcinoma (RCC)

Summary: in renal cell carcinoma (rcc) patients, lymph node metastases detection and treatment are the most critical issues in daily clinical decision-making. indeed, conversely to other oncological settings, a) nodal status imaging, b) sentinel node technique and c) standard lymphadenectomy have been demonstrated inadequate in the staging and management of rcc patients. a novel, accurate, standardized imaging technique is urgently needed in rcc setting to detect macro and micro nodal invasion, to identify those patients who are at higher risk of having nodal metastases, to accurately plan the best management. recent studies suggested combining 18f-faza pet with ct scanning in the detection of cancer-induced hypoxia.the investigators propose to test 18f-faza pet-ct in detecting nodal metastases to improve the management of rcc patients.


Eligibility criteria:
inclusion criteria: * age of at least 18 years with diagnosis of rcc; * patients candidates to radical nephrectomy and extended lymphadenectomy * clinical t4 cancers or renal masses with evidence of lymphadenopathies at preoperative ct scan or larger tumor (max diameter\>10 cm) * performance status 0-1; * expected survival time of at least 3 months; * recovery from toxic effects of any previous treatment; * serum biochemical and haematological measurements within healthy parameters. * female patients of childbearing age were requested to have a negative pregnancy test * ability to understand and understand informed consent * acceptance and signature of informed consent exclusion criteria: * other medical conditions that might limit the amount of antibody to be administered; * new york heart association class iii/iv cardiac disease; * pregnancy and breastfeeding * egfr\<30; * women of child-bearing age who do not agree to use contraceptives to avoid pregnancy; * history of autoimmune hepatitis; * allergy to iodine; * unavailability or immunological and clinical follow-up assessments; * participation in another clinical trial involving an investigational agent within 4 weeks of study enrolment

Keywords: lymph node metastases 18f-faza pet imaging technique
biomarker guided treatment in dlbcl

Conditions: Diffuse Large B Cell Lymphoma

Summary: this study is to investigate the strategy of biomarker guided treatment in diffuse large b cell lymphoma


Eligibility criteria:
inclusion criteria: * pathologically confirmed diffuse large b-cell lymphoma, cd20 positive * ecog 0,1,2 * life expectancy\>6 months * informed consented * ipi\>1 exclusion criteria: * chemotherapy before * stem cell transplantation before * history of malignancy except for basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix * uncontrollable cardio-cerebral vascular, coagulative, autoimmune, serious infectious disease * primary cns lymphoma * lvef≤50% * lab at enrollment (unless caused by lymphoma) neutrophile\ 2\*uln,akp or bilirubin \>1.5\*uln creatinine\>1.5\*uln other uncontrollable medical condition that may that may interfere the participation of the study not able to comply to the protocol for mental or other unknown reasons pregnant or lactation hiv infection if hbsag positive, should check hbv dna, dna positive patients cannot be enrolled. if hbsag negative but hbcab positive (whatever hbsab status), should check hbv dna,dna positive patients cannot be enrolled.
efficacy of prp with er-yag laser versus with microneedling in localized stable vitiligo

Conditions: Localized Vitiligo

Summary: the aims of this study are to:- compare the effect of fractional erbium: yag laser assisted delivery of platelet- rich plasma versus microneedling with platelet-rich plasma in the induction of skin repigmentation in localized stable vitiligo patients.

vitiligo is a depigmentation disease characterised by epidermal melanocyte death and melanin loss. it affects less than 0.1% to greater than 8% of the world's population. it is caused by a dynamic interplay between genetic and environmental risks that initiates an autoimmune attack on melanocytes in the skin. there are some treatment modalities, such as topical steroids, topical calcineurin inhibitors, excimer laser, narrowband-ultraviolet b therapy (nb-uvb), vitamin d,and non-cultured epidermal cell suspension (nces). one of the representative autogenous regenerative biomaterials is platelet-rich plasma (prp) which contains moderate to high concentrations of platelets together with multiple biomolecules and moderate concentrations of leucocytes. activated platelets can release autogenous growth factors that may initiate a signalling cascades and lead to numerous intracellular changes, promoting the proliferation, migration, and differentiation of stem cells and regulating local inflammation and immune responses. laser- assisted drug delivery (ladd) functions by creating focused zones of selective epidermal damage thereby rendering the dermis more accessible to topical medication. multiple lasers have been applied for the purpose of ladd, including ablative fractional carbon dioxide (co2) and erbium-doped yttrium-aluminum-garnet (er: yag) lasers. microneedling (mn) is a minimally invasive process in which many tiny needles penetrate the skin. it augments transdermal drug delivery (tdd) through the creation of pores in the stratum corneum. this technique is also believed to induce pigmentation by physically moving melanocytes with the needles into the vitiligo areas from the pigmented areas, so that they may serve as reservoirs for melanogenesis, also it induces microinflammation which stimulates the migration of keratinocytes and melanocytes that induces the release of cytokines and growth factors stimulating melanocytes at the periphery of vitiligo patches and their migration from pigmented to unpigmented areas.

Eligibility criteria:
inclusion criteria: - 1) patients of both sexes with stable localized vitiligo: stable patches (should not have any increase or decrease in size or pigmentation for at least 3 months) . 2)age between 10 - 60 years exclusion criteria: * 1)acute or chronic infections. 2) koebner phenomenon. 3) contraindications to prp injections: * patients with blood or platelet abnormalities. * patients taking anti-platelet drugs or anticoagulants. * patients with a history of altered or abnormal fibroblast function, such as collagen diseases or myelofibrosis. 4) we also excluded pregnant or lactating women. 5) all patients included had not received any local or systemic medication for at least 2 months before the study.
open label study to evaluate the efficacy of the home based electrical transcutaneous uris i in the treatment of overactive bladder (oab).

Conditions: Overactive Bladder (OAB); Failed Any OAB Pharmacotherapy

Summary: open label study to evaluate the efficacy of the home based electrical transcutaneous neuromodulation (etnm) treatment via nerve stimulator uris i in the treatment of overactive bladder.

open label, multi center study to evaluate the efficacy of the home based electrical transcutaneous neuromodulation (etnm) treatment via nerve stimulator uris i in the treatment of overactive bladder (oab).

Eligibility criteria:
inclusion criteria: * women 18 years or older, inclusive * diagnosis of oab or mixed incontinence with the predominance of oab symptoms * dissatisfaction with any current or previous pharmacotherapy treatment of oab for any reason within the past 12 months * treatment satisfaction vas \<50 * ability to understand and sign icf * subject agreed to attend all follow up evaluations and was willing to completely and accurately fill out voiding diaries and questionnaires, and was willing to complete required exams and tests * subject agreed not to participate in another research study from the time of screening until the final study visit * subject agreed not to use a pharmacotherapy treatment for oab from the time of screening until the final study visit exclusion criteria: * prior treatment with botulotoxin for oab * previous pharmacotherapy for oab if \>12 months ago * urinary retention with post void residual \> 150ml * neurological disease affecting urinary bladder function, including but not limited to parkinson's disease, multiple sclerosis, stroke, spinal cord injury and nerves of lower limbs * history or presence of stress incontinence, or mixed incontinence where stress incontinence was predominant
breast cancer screening in ghana

Conditions: Breast Cancer Female

Summary: this study is designed to test the feasibility of two intervention on promoting early screening for breast cancer in rural ghana. in one intervention, screening for breast cancer, diabetes and hypertension will be offered together. in another intervention, a series of sessions with men will be conducted with a goal to change gender attitudes and increase support to women. the investigators' long-term goal is to test these interventions in a large-scale randomized controlled trial. the specific aims of this feasibility study are to: 1) refine the study materials, including the curriculum for the sessions with men, by consulting with an expert advisory committee and a local committee, and 2) determine the feasibility of the two interventions in four clinic zones in yilo-krobo district in eastern ghana (1 clinic in control, 1 clinic in the first intervention, and 2 in the second intervention). this trial registration is for the second specific aim.


Eligibility criteria:
inclusion criteria: * ≥20 years. the age cutoff reflects early onset of bc in ghana and the government's guidelines on screening. exclusion criteria: * ever clinically diagnosed with a case of breast cancer, as the study's aim is to reach women who would normally not visit or have experience with the health system with regard to breast cancer. note: for men in the megh arm, inclusion and exclusion criteria are: inclusion criteria: aged ≥20 years who are identified as male partners or relatives by the women enrolled in the megh group. exclusion criteria: none.
the effects of fodmaps in patients with irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: patients with irritable bowel syndrome (ibs) often link their symptoms to foods. interest in dietary management recently increased, including the use of a low fodmap diet. to investigate relation of fodmaps and ibs, a randomized, double-blind, cross-over trial will be carried out in adult (\>18) patients with ibs according to rome iv criteria. the aim is to assess low fodmap diet versus moderate/high fodmap diet in ibs patients.

the study is a randomized, double-blind, cross-over trial. the aim is to assess the effects of low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (fodmap) diet compared to moderate/high fodmap diet in ibs patients on gastrointestinal symptoms and psychological factors. the primary hypothesis is that the low fodmap diet decreases gastrointestinal symptoms compared to moderate/high fodmap diet, and that this change is accompanied with reduced psychological distress. ibs patients (rome iv) are challenged with fodmaps in this randomized, double-blinded, cross-over study. the subjects will start with the low fodmap diet or moderate/high fodmap diet and cross over to the other intervention (both for 7 days). in between the interventions, there is a wash-out period of at least 14 days. the subjects will receive ready-made meals from the hospital kitchen (lunch and dinner) and in between snacks. the subjects are instructed to buy breakfast themselves and the subjects will receive information on which other foods to avoid, without mentioning 'fodmaps'. the subjects will follow their usual diet (as before initiation of the study) during the wash-out period. primary outcomes are change in gastrointestinal symptoms, assessed by questionnaires, including ibs severity scoring system (ibs-sss) (7-10 day recall and modified daily) and gastrointestinal symptom rating scale -ibs (gsrs-ibs). a 50-point reduction in ibs-sss indicates clinical response. bacterial fermentation (exhaled hydrogen and methane) and visceral sensitivity will be measured using the lactulose nutrient challenge test. secondary outcomes are change in psychological factors and assessed by questionnaires, including central sensitization index (csi), hospital anxiety and depression scale (hads), patient health questionnaire (phq)-15 and visceral sensitivity index (vsi).

Eligibility criteria:
inclusion criteria: * adult patients with ibs according to rome iv criteria exclusion criteria: * allergy or documented intolerance to food * severe cardiovascular disease * severe hepatic disease * severe neurological disease * severe psychiatric disease * celiac disease * inflammatory bowel diseases * diabetes * bowel dysfunction related to previous surgery * pregnant or lactating women * use of antibiotics within four weeks before inclusion * strict avoidance of foods

Keywords: fodmaps carbohydrates gastrointestinal symptoms ibs
cardiovascular risk factors in an ambulatory urban patient population

Conditions: Cardiovascular Risk Factors; Metabolic Syndrome; Lifestyle Modification; Coronary Artery Disease; Stroke

Summary: according to who estimations, cardiovascular diseases (cvds) are the number one cause of death globally. more people die annually from cvds than from any other cause. an estimated 17.5 million people died from cvds in 2005, representing 30% of all global deaths. of these deaths, an estimated 7.6 million were due to coronary heart disease and 5.7 million were due to stroke. over 80% of cvd deaths take place in low- and middle-income countries and occur almost equally in men and women. in paraguay, prevalence of classic risk factors, as well as new ones, like the metabolic syndrome are not completely known. government health policies in industrialized countries are focusing on programs to modify cardiovascular risk factors. in developing countries, prevention of coronary heart disease and stroke through modification of cardiovascular risk factors are not playing a large role at the moment. the aim of this study is to define the effects of changes in lifestyle on cardiovascular risk factors, when added to optimized standard pharmacological therapy for arterial hypertension, diabetes mellitus and hyperlipidemia, in an ambulatory urban patient population.


Eligibility criteria:
inclusion criteria: * all ambulatory patients, with age 18 years or older exclusion criteria: * no exclusion criteria provided, particularly for the first, epidemiological part of the study

Keywords: diet exercise smoking stress polyphenols