Kornimate/medical-research-clean huggingface dataset:
the effectiveness of sweet solution versus cryotherapy in reducing pain during administration of local anesthesia among children

Conditions: Pain

Summary: the porpose of study to assess the effectiveness of sweet solution versus cryotherapy in reducing pain during administration of local anesthesia among children

this study to assess the effectiveness of sweet solution versus cryotherapy in reducing pain during administration of local anesthesia among children

Eligibility criteria:
inclusion criteria: 1. children with behavior rating score 2,3 or 4 of frankl's behavior rating scale 2. children aged 6-11 years requiring dental injections for pulpectomy, root canal treatment, or extraction procedures for primary and permanent mandibular molars. exclusion criteria: 1. allergy to lidocaine 2. redness at the site of injection؛ and a history of abscess, sinus tract, or fistula associated with the teeth. 3. children with special health care needs. 4. children suffering from systemic diseases. 5. extremely uncooperative children.

Keywords: dental pain anesthesia sucrose cryotherapy topical anesthesia
the detection of early dementia with the digital game memory

Conditions: Alzheimer's Disease

Summary: the investigators are going to test if it is possible to detect early dementia with the digital game "memory". the investigators are going to test 15 healthy people and 15 patients with early dementia. the test consists of playing the game "memory" several times. while playing, several parameters are stored. the investigators are going to test if any correlation can be found between these parameters and the cognitive state of the person as tested by the mini-mental status examination.


Eligibility criteria:
inclusion criteria: * healthy 75-plusser * 75-plusser with early dementia exclusion criteria: * younger than 75 * patient with other cognitive impairments than dementia
a study of db-1202 monotherapy in advanced solid tumors

Conditions: Advanced Solid Tumor

Summary: this is a dose-escalation and dose-expansion phase 1/2a trial to evaluate the safety and tolerability of db-1201 in subjects with advanced solid tumors.

this is a multicenter, non-randomized, open-label, multiple-dose, fih study. the study consists of two parts: part 1 adopts a rule based "3 + 3" design to identify mtd/rp2d; part 2 is a dose expansion phase to confirm the safety, tolerability and efficacy in selected solid malignant tumors.

Eligibility criteria:
inclusion criteria: 1. male or female at least 18 years old. 2. has histologically or cytologically confirmed metastatic or locally advanced solid tumors for which no effective standard therapy existed or standard of care has failed or is not considered as an option. 3. is capable of comprehending study procedures and risks outlined in the informed consent and is willing to provide written consent. 4. has an eastern cooperative oncology group performance status (ecog ps) of 0-1. 5. at least one measurable lesion as assessed by the investigator according to response evaluation criteria in solid tumors (recist) version 1.1 criteria. 6. has adequate organ function within 7 days prior to initiation of the first treatment cycle 7. platelet count ≥ 100 000/mm3 8. hemoglobin (hb) ≥ 8.5 g/dl 9. absolute neutrophil count (anc) ≥ 1500/mm3 10. creatinine ≤ 1.5 × upper limit of normal (uln), or 11. creatinine clearance ≥ 60 ml/min (modification cockcroft-gault equation) exclusion criteria: 1. has a medical history of symptomatic chronic heart failure (chf) (new york heart association \[nyha\] classes ii-iv) or serious cardiac arrhythmia requiring treatment. 2. has a medical history of myocardial infarction or unstable angina within 6 months before day 1. 3. has a qtc prolongation to \> 470 millisecond (ms) based on a 12-lead electrocardiogram (ecg) in triplicate. 4. active or prior documented autoimmune disease within the past 2 years. note: subjects with a history of autoimmune thyroid disease are not excluded. subjects with vitiligo or psoriasis not requiring systemic treatment (within the past 2 years) are not excluded. 5. active or prior documented inflammatory bowel disease (e.g., crohn's disease, ulcerative colitis). 6. history of primary immunodeficiency. 7. history of allogeneic organ transplant. 8. has an uncontrolled infection requiring iv injection of antibiotics, antivirals, or antifungals. 9. known human immunodeficiency virus (hiv) infection, or active hepatitis b or c infection. 10. is a lactating mother (women who are willing to temporarily interrupt breastfeeding will also be excluded), or pregnant as confirmed by pregnancy tests performed within 7 days prior to initiation of the first treatment cycle. 11. male and female subjects who are unwilling to use adequate contraceptive methods (double barrier or intrauterine contraceptive) during the study and for at least 7 months after the last dose of study drug.

Keywords: tgf-β thyroid cancer
arthroscopic biological augmentation with subacromial bursa for bursal side partial-thickness rotator cuff tears

Conditions: Partial Thickness Rotator Cuff Tears

Summary: the investigators aimed to compare the results of acromioplasty + arthroscopic debridement and acromioplasty + augmentation with subacromial bursa.


Eligibility criteria:
inclusion criteria: * bursal side rotator cuff tears in mri sections * patients whose pain does not go away despite nsaids and standardized physical therapy by the same physiotherapist applied for 3 months * 25-50% or 3-6 mm rotator cuff tear (ellman grade 2) on the bursal side exclusion criteria: * previous surgery * tears greater than 50% or 6 mm

Keywords: partial thickness bursal side rotator cuff full thickness subacromial bursa
magnetic seizure therapy versus electroconvulsive therapy for schizophrenia

Conditions: Schizophrenia

Summary: this trial attempts to evaluate the treatment efficacy of magnetic seizure therapy (mst) and its safety among schizophrenia patients. half of the participants will be randomized to mst group, while the other half will be randomized to receive electroconvulsive therapy (ect).

magnetic seizure therapy (mst) is likely to be an alternative options to electroconvulsive therapy (ect). widespread stimulation of cortical and subcortical regions is inevitable for ect since the substantial impedance of the scalp and skull shuts most of the electrical stimulus away from the brain. nevertheless, magnetic pulses are capable to focus the stimulus to a specific area of the brain because they can pass the scalp and skull without resistance. in addition, electric current will penetrate into deeper structures, while magnetic stimulus are only capable to reach a depth of a few centimeters. as a consequence, mst are able to generate focus stimuli on superficial regions of the cortex while ect can't, which may give mst the capability to produce comparable therapeutic benefits with the absence of apparent cognitive side effects. however, mst and ect may both works via alterations of cortical inhibition and default mode network.

Eligibility criteria:
inclusion criteria: 1. dsm-5 diagnosis of schizophrenia; 2. convulsive therapy clinically indicated, such as severe psychomotor excitement or retardation, attempts of suicide, being highly aggressive, pharmacotherapy intolerance, and ineffectiveness of antipsychotics; 3. the positive and negative syndrome scale (panss)\[20\] score ≥ 60; 4. informed consent in written form. exclusion criteria: 1. diagnosis of other mental disorders; 2. severe physical diseases, such as stroke, heart failure, liver failure, neoplasm, and immune deficiency; 3. present with a laboratory abnormality that could impact on efficacy of treatments or safety of participants; 4. failure to respond to an adequate trial of ect lifetime; 5. are pregnant or intend to get pregnant during the study; 6. other conditions that investigators consider to be inappropriate to participate in this trial.

Keywords: magnetic seizure therapy electroconvulsive therapy controlled trial
cochlear-vestibular ganglion (cvg) in newly diagnosed type 2 diabetes patients

Conditions: Diabetes Mellitus Type 2 in Obese

Summary: the proposed study is an integrative scientific undertaking, reflecting the input of experts in the behavioral sciences, mhealth technology, computational biology, endocrinology, biochemistry, and nutrition. the project features a unique translational approach, connecting behavior and biology in an economical manner that provides mechanistic insights into the progression of type 2 diabetes (t2d) and the biologic consequences of behavior change. the project may have profound implications for the clinical management of early t2d.

t2d poses a significant public health problem. hyperglycemia is associated with a variety of vascular complications, but clinical trials of medication regimes designed to achieve near-normal hba1c have been mostly negative. the lack of benefit observed in these trials may be due to the fact that they targeted hba1c rather than glucose variability, and were conducted in patients with established t2d that had already experienced complications of the disease. in early t2d, management of postprandial glycemia may be particularly important for minimization of metabolic memory effects and preservation of beta cell function. postprandial glycemia in early t2d is largely driven by dietary intake, but research findings that guide clinicians regarding the best dietary approach to prescribe are mixed. studies done, to-date, have used one-size-fits-all dietary regimes that do not take into consideration the person's unique glycemic response to food. the investigators know from decades of research that behavioral methods are required to engage patients in lifestyle behavior change. the investigators argue that tailoring the approach to the participant's glycemic response and gut microbiome will enhance self-efficacy in ways that cannot be achieved through standard behavioral methods alone and, in turn, reduce glycemic variability and metabolic memory effects. co-pi segal et al. demonstrated that subjects have high between-subject variability in postprandial response to the same food, suggesting that universal dietary recommendations are of limited utility for controlling elevated postprandial glucose. the machine learning algorithm devised by the group integrates multidimensional data to accurately predict personalized postprandial glycemic responses. in a subsequent validation study in 100 participants, they showed that a personally-tailored intervention based on the predicted response resulted in significantly improved postprandial glycemic response, and were accompanied by beneficial changes in gut microbiota.

Eligibility criteria:
inclusion criteria: * 5 years or less since type 2 diabetes was diagnosed exclusion criteria: * more 5 years since type 2 diabetes was diagnosed
role of the endothelium in stroke-like episode among cdg patients

Conditions: Congenital Disorders of Glycosylation

Summary: the aim of the study is to evaluate the role of the endothelial barrier in the occurrence of stroke-like episode. and to study the protein c system on the surface of the endothelium.

the study consists in isolating endothelial progenitor cells in peripheral blood. after blood puncture, pbmc (peripheral blood mononuclear cell) are isolated by ficoll gradient and then culturing in appropriated medium. when cells are confluent, investigators can study the endothelial barrier by using permeability assay and transendothelial resistance test (icelligence technology). then, protein c system will be studied. indeed, epcr (endothelial protein c receptor) and tm (thrombomodulin), are the two receptors responsible for the activation of protein c. the expression of these receptors will be assessed in flow cytometry. the activated protein c is able to interact with the third receptor par1 (protease activated receptor 1) which is responsible for the protective effects of the on the endothelial barrier. the par1 expression will be studied in flow cytometry also. in order to measure the capacity of the protein c system to generate activated protein c investigators will assay an activated protein c generation on the cell surface. all these assays will be realized in basal condition and in heat stress (42°c), to mimic the stroke-like episode environment. indeed, stroke-like episodes occur always during febrile illness.

Eligibility criteria:
inclusion criteria: * patients with cdg molecularly diagnosed * with stroke-like history or not exclusion criteria: * rejection to participate in research

Keywords: cdg stroke-like endothelial progenitor cells (epcs) protein c congenital disorders og glycosylation
evaluation of the endometrial cavity after endometrial ablation

Conditions: Menorrhagia

Summary: the purpose of this study is to evaluate the shape, size and appearance of the inside of the uterus six months following an endometrial ablation procedure. half of the participants will have their ablation performed with a hydrothermal ablation device and the other half will have their ablation performed with a device that uses radiofrequency energy.

the purpose of this study is to evaluate the shape, size and appearance of the inside of the uterus six months following an endometrial ablation procedure. half of the participants will have their ablation performed with a hydrothermal ablation device and the other half will have their ablation performed with a device that uses radiofrequency energy. participants are randomly assigned to one or the other device. a vaginal ultrasound will be performed before the procedure and again at six months post-procedure. the inside of the uterus will be visualized via hysteroscopy before the procedure and again at six months post-procedure. measurements will be taken and the investigator will compare photos taken pre-procedure and six months post-procedure.

Eligibility criteria:
inclusion criteria: * premenopausal women not pregnant and no future pregnancy desired willing to randomize the device used for the ablation willing to undergo diagnostic hysteroscopy with office-based anesthesia 6 months post-ablation exclusion criteria: * pregnancy or desiring future pregnancy endometrial hyperplasia presence of active endometriosis active pelvic inflammatory disease previous endometrial ablation procedure

Keywords: endometrial ablation, menorrhagia
vitamin b12 and dextrose for median nerve hydrodissection

Conditions: Carpal Tunnel Syndrome

Summary: carpal tunnel syndrome is the most common peripheral entrapment neuropathy of the upper limb. previous experiments found that ultrasound-guided median nerve hydrodissection with 5% dextrose water could ameliorate the condition of carpal tunnel syndrome. oral administration of vitamin b 12 had been reported to reduce the discomfort from peripheral neuropathy although the level of evidence is not strong. this prospective, double-blind randomized control trial aims to compare the effects of different kinds of the injection agents on carpal tunnel syndrome.


Eligibility criteria:
inclusion criteria: * age between 20-80 year-old. * diagnosis (carpal tunnel syndrome) was confirmed using an electrophysiological study. exclusion criteria: * previously undergone wrist surgery or steroid injection for cts * thrombocytopenia * coagulopathy * inflammation status * polyneuropathy * brachial plexopathy * cervical radiculopathy * autoimmune disease * malignancy * pregnancy thoracic outlet syndrome
effect of nuvigil on fatigue

Conditions: Menopause

Summary: the purpose of this study is to determine if armodafinil improves quality of life and is an effective treatment of fatigue in symptomatic perimenopausal and postmenopausal women.

fatigue is one of the most prevalent symptoms occurring in peri- and postmenopausal women. it is strongly associated with reduced quality of life in this population. studies have shown a strong association between fatigue and menopausal symptoms such as hot flashes, vaginal symptoms, and sexual dysfunction. because sleep disturbance commonly co-occurs in women with hot flashes as a result of nocturnal hot flashes disrupting sleep, sleep disturbance may explain the association between hot flashes and fatigue in this population. however evidence suggests that fatigue can occur in the absence of sleep disruption, indicating that sleep problems do not exclusively explain the etiology of fatigue in this population. armodafinil is a wakefulness-promoting agent that acts as a central nervous system stimulant. it is chemically and pharmacologically unrelated to other cns stimulants, such as methylphenidate and amphetamine. armodafinil is fda approved to increase wakefulness in patients with excessive sleepiness due to narcolepsy, obstructive sleep apnea, and shift work sleep disorder. it has not be studied in menopause-associated fatigue. in the proposed study, the investigators plan to investigate the effect of armodafinil on quality of life and fatigue in a population of peri- and postmenopausal women with fatigue and reduced quality of life who do not have primary sleep disorders, significant levels of insomnia, or depression.

Eligibility criteria:
inclusion criteria: women * ages 40-65 * peri- and postmenopausal * suffering from fatigue * experiencing hot flashes(not required for perimenopausal women) exclusion criteria: * current episode of major depression * moderate-to-severe insomnia * night shift workers * previous diagnosis of manic depressive disorder, psychotic disorder, or psychotic symptoms * suicidal ideation * alcohol/drug abuse * concern about potential misuse of study medication * use of prescribed medications to treat insomnia or other sleep disturbance symptoms * pregnant or breastfeeding * use of systemic menopausal hormonal therapy or birth control * use of centrally active medications, such as antidepressants, anxiolytics, and hypnotics agents * use of clopidogrel * use of atomoxetine * cardiovascular contraindications of use of armodafinil

Keywords: fatigue menopausal symptoms hot flashes vasomotor symptoms perimenopause related quality of life
examining bluetooth haptic device use for pain and anxiety reduction in vascular access procedures

Conditions: Pain; Anxiety

Summary: this pragmatic, randomized study seeks to evaluate the applications of a novel vibrating device for reducing pediatric anxiety and distress during vascular access procedures.


Eligibility criteria:
inclusion criteria: * between age 4-99 * will undergo a vascular access procedure * english speaking participant and parent or lar exclusion criteria: * legal guardian not present to obtain consent * child is unable to self-report pain or anxiety * child with a significant neurological condition, or major developmental disability * child with active infection of the hand or arm * major surgery within the last 48 hours

Keywords: vascular access
ketogenic diets for weight loss maintenance: impact on energy expenditure and appetite in individuals with obesity

Conditions: Obesity

Summary: the goal of this clinical trial is to investigate whether a ketogenic diet (kd) can increase total energy expenditure (tee), while benefiting appetite, during weight loss maintenance in reduced-obese individuals.

the total duration of the intervention will be 10 weeks. participants will first undergo 4 weeks of a low-energy diet (led), aiming to induce a minimum of 5 % weight loss (weight loss phase). this will then be followed by a 2-week refeeding and weight stabilization phase and those achieving a weight loss of at least 5% of baseline weight by the end of week 6, will then be randomized (1:1) to undergo a 4-week weight loss maintenance (wlm) phase with either a kd or an isocaloric low-fat diet.

Eligibility criteria:
inclusion criteria: * bmi 30-45 kg/m2 * both men and women * age between 18-65 years * sedentary to moderately active (\<2 h/wk of moderate, structured, intentional, exercise) exclusion criteria: * pregnancy or lactation * daily use of tobacco (\>1 pk/wk) * change in weight greater than 5 lb in the previous 3 months * cognitive impairment * previous bariatric surgery * history of eating disorder * presence of any condition (e.g. dm2, pcos, inflammatory disease, untreated thyroid disease, fluid overload states such as chronic kidney disease, congestive heart failure, or cirrhosis) * use of any medication (e.g., glucocorticoid, glp-1 analogues, hormone replacement therapy) deemed to interfere with study outcomes. * pre-menopausal women will need to have a regular menstrual cycle (28+/-2 days) or be on hormonal contraceptives * fasting glucose plasma concentration \>125 mg/dl and/or hba1c \> 6.4%

Keywords: ketogenic diet weight loss weight loss maintenance appetite energy expenditure
the impact of tai chi combined with music therapy intervention on depression and anxiety among college students

Conditions: Unrecognized Condition

Summary: this study aims to investigate the effects of tai chi combined with music therapy on alleviating depression and anxiety among college students. depression and anxiety are prevalent among college students and have a significant impact on their lives and academic performance. therefore, exploring effective interventions is crucial for promoting the mental health of college students.


Eligibility criteria:
inclusion criteria: * this study were being enrolled as a student at tianjin university of sport * aged between 18 and 25 years * proficient in reading and communicating in chinese. exclusion criteria: * students with visual impairments * students with auditory * students with other impairments

Keywords: tai chi combined with music therapy depression anxiety college students
surveillance of treatment of children with growth hormone deficiency with zomacton®

Conditions: Growth Hormone Deficiency

Summary: the purpose of this study is to investigate the long-term treatment with zomacton® for pituitary short stature in children with insufficient growth hormone production and/or short stature caused by turner's syndrome.


Eligibility criteria:
inclusion criteria: * therapeutic need according to the approved specific products characteristics (spc) exclusion criteria: * contraindication according to the spc