Kornimate/medical-research-clean huggingface dataset:
post operative pain after endodontic retreatment

Conditions: Retreatment

Summary: clinical trial the aim of this clinical study was to evaluate the effect of different root canal sealers on post operative pain after a single session endodontic retreatment of the teeth have single root and canal with chronic apical periodontitis. the main questions aimed to be answered are: which of the patients treated with ahplus, sureseal and sealapex root canal sealers had more postoperative pain after endodontic retreatment? which of the patients that treated with ahplus, sureseal and sealapex root canal sealers required more analgesic intake after endodontic retreatment? participants: undergo a single session of endodontic retreatment using one of ah plus, sureseal or sealapex root canal sealers. visit the clinic one week later after endodontic retreatment write the condition of analgesic intake and pain score at 6, 12, 24 hours and 2, 3, 4, 5, 6 and 7 days after treatment using a visual analog scale.


Eligibility criteria:
inclusion criteria: * patients who did not have any systemic disease, pregnancy or breastfeeding, * patients who were older than 18 years, * patients who had not used analgesics, anti-inflammatory or antibiotics in the last 7 days and cortisone in the last 6 months, * patients who had improved communication skills and were at a mental level to express pain scoring clearly, * patients who did not have bruxism problem or primary contact were included in the study. * teeth with more than 60% of the root canal filled have preoperatively asymptomatic single root and single canal with previous root canal treatment and chronic apical periodontitis and periapical index (pai) scores 2-4 exclusion criteria: * teeth had root resorption, * teeth had crown damage * teeth had severe malocclusion, * teeth had pai scores 1 and 5 * immature teeth

Keywords: endodontic retreatment root canal sealer post operative pain
microarray expression profiling to identify stereotypic mrna profiles in human parturition

Conditions: Preterm Birth; Premature Rupture of Membranes

Summary: the understanding of the biological mechanisms underlying preterm birth is very limited, making prevention of preterm birth difficult. the incidence of preterm birth worldwide varies between 6%-11% in singleton pregnancies, and 64-93% of preterm deliveries occur after the spontaneous onset of labor (preterm labor). the risk factors associated with preterm birth include demographic variables such as ethnic group, past obstetric history, and complications of the current pregnancy such as infection and fetal congenital anomalies. the current study aims to investigate the basic mechanisms of preterm labor by systematically cataloging the changes in expression levels of all expressed genes whose sequences are available. the goals will be accomplished by using microarray technology followed by subsequent confirmative or complementary analyses.

the understanding of the biological mechanisms underlying preterm birth is very limited, making prevention of preterm birth difficult. the incidence of preterm birth worldwide varies between 6%-11% in singleton pregnancies, and 64-93% of preterm deliveries occur after the spontaneous onset of labor (preterm labor). the risk factors associated with preterm birth include demographic variables such as ethnic group, past obstetric history, and complications of the current pregnancy such as infection and fetal congenital anomalies. the current study aims to investigate the basic mechanisms of preterm labor by systematically cataloging the changes in expression levels of all expressed genes whose sequences are available. the goals will be accomplished by using microarray technology followed by subsequent confirmative or complementary analyses.

Eligibility criteria:
* inclusion criteria: consecutive patients admitted with the following diagnoses from four different ethnic groups (hispanic, african american, asian, and caucasian): 1. preterm labor with intact membranes and with 1. acute inflammation; 2. chronic villitis; 3. vascular pathology; 4. no identifiable lesions. 2. preterm delivery without labor because of the following reasons: 1. pre-eclampsia; 2. abruptio placentae; 3. fetal anomalies; 4. other complications (e.g. automobile accidents) that necessitate immediate delivery. 3. prom leading to preterm delivery and with 1. acute inflammation; 2. chronic villitis; 3. vascular pathology; 4. no identifiable lesions. 4. term delivery without labor and no identifiable lesions. 5. term delivery in spontaneous labor and no identifiable lesions. 6. term delivery with chorioamnionitis. 7. term delivery with failed labor leading to ceasarean section. exclusion criteria: 1. refusal of written informed consent 2. fetal or maternal conditions mandating immediate delivery (i.e. fetal distress, significant hemorrhage, etc.)

Keywords: genetic risk factors tissue specific expression quantitative real time pcr preterm birth expression profiling natural history
sentinel lymph node biopsy after neoadjuvant chemotherapy for locally advanced breast cancer

Conditions: Breast Cancer; Locally Advanced Breast Cancer

Summary: this study is being done to help the investigators determine how accurate the sentinel lymph node biopsy (slnb) procedure is in identifying residual cancer cells after neoadjuvant chemotherapy in patients presenting with locally advanced breast cancer.


Eligibility criteria:
inclusion criteria: * female patients over 18 years of age with biopsy-proven breast cancer * patients presenting with locally advanced disease in the breast (ct4) and/or in the nodes (cn2/n3) as assessed by clinical exam and imaging * patients presenting to surgery clinic after receipt of nac at outside hospital with documentation of ct4 or cn2/3 disease on initial outside physical exam and imaging studies * patients receiving nac and having a nodal complete clinical response as assessed by physical exam exclusion criteria: * patients with a prior history of ipsilateral breast cancer * pregnant patients * patients with persistent palpable axillary nodes after nac, as assessed by physical exam * patients not consenting to alnd

Keywords: sentinel lymph node biopsy 17-384
trajectory of psychological distress among infertility women

Conditions: Infertility; Heart Rate Variability; Biofeedback

Summary: background: infertility is a serious reproductive health issue and affects 48.5 million couples worldwide. women undergoing fertility treatment often experienced psychological distress but also social stigma that is close linked to later pregnancy outcome. despite the advancement in assisted reproductive technology, effective interventions for reducing stress, anxiety, and depressive symptoms for infertility women remain lacking. objectives: the objective of this proposal is to evaluate the efficacy of web-based mind-body intervention combining hrv biofeedback on the infertility women's anxiety symptoms, levels of depression, hrv function, mindful awareness, infertility self-efficacy, and pregnancy rates. methods: we plan to conduct a randomized controlled trial on the web-based mind-body intervention combining heart rate variability biofeedback. eligible women will be recruited and randomized into three groups. intention-to-treat analysis and mixed regression modeling will be used to estimate the effectiveness of the interventions. anticipatory results: effective strategies will be determined for infertility women.

a designed data entry system for the current study will be developed to ensure an error-proof process. it is important to inspect data for outliers, wild code, and consistency to maintain the data quality in the pre-analysis data phase. we will assess the amount and pattern of missing values by using descriptive statistics, such as frequency and percentage. the pattern of missing data will be identified and decide whether the missing completely at random or not. the appropriate corresponding method will be adopted for the subsequent statistical analyses. for example, the mean imputation is considered when the percentage of items missing at a given questionnaire is less than 10 %. the mean imputation will be used to replaces a missing value with the item mean when applicable. the comparison between complete case analysis and imputation data will be performed to assess the reliability and validity of the results.

Eligibility criteria:
inclusion criteria: * 20-year-old and above * seeking infertility care * contemplating pregnancy * intended to start their art cycle * able to speak taiwanese or mandarin exclusion criteria: * diagnosis of cardiovascular disease, depressive disorder, anxiety disorder, cardiac arrhythmia * already had started their art treatment * taking medications that might affect ans activity

Keywords: infertility mind-body intervention heart rate variability biofeedback psychological distress
study of breath-holding as a means to reduce tumor motion from breathing

Conditions: Neoplasm, Metastatic

Summary: the purpose of this research study is to evaluate typical tumor motion caused by breathing using mri and can help determine whether simple passive breathing and/or breath-holding could be used for the future treatment of similar lung and liver tumors using radiation therapy radiosurgery techniques.


Eligibility criteria:
inclusion criteria: * the patient is enrolled on u8700 rsrb # a phase ii study for using radiosurgery on limited metastases of breast cancer or u9700 a pilot study for using radiosurgery on limited metastases. * ≥ 18 years of age * has given informed consent exclusion criteria: -contraindications for any mri procedure
assessing the immediate increase in serum ferritin after oral iron doses

Conditions: Iron Deficiency (Without Anemia)

Summary: serum ferritin is a key indicator of body iron stores and is widely used in monitoring iron status. however, oral iron doses can acutely elevate sf levels, potentially biasing assessments of iron stores during supplementation. this study aims to investigate the extent and duration of the acute iron-induced effect on serum ferritin, as well as its protein characteristics, following the administration of a single iron dose


Eligibility criteria:
inclusion criteria: * low iron stores (sf levels \< 30 µg/l), * no anemia (hb \> 120 g/l) * no inflammation (crp \< 5 mg/l) * 18 to 45 years old. * body weight \<70 kg * normal body mass index (18.5-26.5 kg/m2) exclusion criteria: * any chronic or acute disease * consumption of mineral and vitamin supplements since screening and over the study period * blood transfusion, blood donation or significant blood loss over the past 6 months, * pregnant or breastfeeding, * continuous/long-term use of medication during the whole studies (except for contraceptives) * therapeutic iron infusion over the past 6 months, * known hypersensitivity or allergy to iron supplements, * intention to become pregnant over the course of the study

Keywords: oral iron supplementation serum ferritin
oculomotor response while using a helmet display incorporating an accommodation-vergence stress reduction algorithm

Conditions: Visual Fatigue

Summary: operational military personnel are increasingly using virtual or augmented reality headsets in the field or in training. however, these devices cause a conflict between accommodation (focus to see clearly) and vergence (alignment of both eyes on the object being viewed) that can be a source of visual fatigue and altered visual and perceptual abilities. although techniques exist to limit this conflict for screen-based stimuli, the use of helmet visuals (or immersive headsets) adds technological complexity. indeed, since accommodation on the screen of the helmet visual is impossible (i.e., distance too small) for the human visual system, lenses are used to virtually shift the image (referred to as a collimated image) so that accommodation can occur much further away. however, this material configuration also modifies the vergence, thus causing a conflict between accommodation and additional vergence that persists regardless of the attenuation technique used. in this study, the investigator proposed to modify the image display to take into account the technical features of the helmet to correct this techno-dependent conflict. this study is aimed at determining whether the setting recommended by the algorithm developed by the investigator limits visual fatigue better than the conventional setting recommended by manufacturers or a subjective setting controlled by the user.


Eligibility criteria:
inclusion criteria: * age over 18 * non-presbyopic * stereoscopic acuity ≤ 60 min of arc exclusion criteria: * accommodative insufficiency (app ≤ 13-"age"/4, in diopters) * accommodative inertia (+ and - block in binocular) * compensation by orthokeratology * present or past binocular pathology: strabismus or amblyopia

Keywords: virtual reality
pain increases after shoulder injection

Conditions: Shoulder Pain

Summary: compare flare reactions (increase in vas by two or more points) in the first 48 hours following a shoulder injection.

corticosteroid injections are used to reduce pain and inflammation for various shoulder pathologies. corticosteroid flare reaction is a well-described phenomenon that, despite being self-limited, causes significant pain and dysfunction. a flare reaction is defined for the purposes the study to be an increase of two or more points on a visual analog scale reported by the subject. currently, there is a paucity of literature to drive the decision-making process between different corticosteroid medications. this study will compare the incidences of steroid flare reaction and three-month efficacy following methylprednisolone acetate (mpa) and triamcinolone acetonide (ta) corticosteroid injections into the glenohumeral joint or subacromial space. physicians administering a steroid injection in the shoulder will utilize mpa until 200 subjects have agreed to participate in this treatment arm. enrollment will then be offered to 200 subjects utilizing ta for the shoulder injection. subjects receive treatment for their shoulder pain regardless of willingness to participate in the follow up reported pain scores. there are no costs to subjects for study participation.

Eligibility criteria:
inclusion criteria: * subacromial or glenohumeral shoulder pain to be treated with steroid injection * fluent in written and oral english * willing and able to provide written consent * willing to complete follow up pain scores (visual analog score) exclusion criteria: * unable to provide written consent * chronic pain syndrome * unwilling to complete follow up pain scores (visual analog score)
comparing the efficacy of visible light-ultraviolet a1 light versus narrowband-ultraviolet b on generalized vitiligo

Conditions: Generalized Vitiligo

Summary: as part of this study, you may have a procedure called phototherapy which involves either vl-uva or nb-uvb irradiation. nb-uvb phototherapy is not experimental in vitiligo, but use of vl-uva1 phototherapy in vitiligo is. the purpose of this pilot study is to determine whether vl-uva1 or nb-uvb phototherapy more efficiently induces repigmentation in patients with generalized vitiligo.


Eligibility criteria:
inclusion criteria: * subjects ≥ 18 years of age with a diagnosis of generalized vitiligo * subjects on a stable topical/oral regimen for the past 3 months and continuing on a stable regimen * subjects able to understand the requirements of the study * subjects able and willing to sign informed consent exclusion criteria: * subjects on photosensitizing medications * subjects receiving any concurrent phototherapy * subjects who plan to use tanning parlors or expose themselves to excess sunlight * subjects with known photosensitivity disorder * subjects with apparent phototoxicity * subjects with unstable vitiligo * subjects currently using bleaching agents * subjects who are pregnant, lactating, or planning on becoming pregnant * subjects who in the opinion of the investigator/sub-investigator, are not appropriate candidates for this study
cp-690,550 thorough qtc study

Conditions: Healthy

Summary: ich e14 recommends that a thorough qt/qtc (tqt) study should be performed to determine whether intensive monitoring of qt interval in target patient populations is required during later stages of development. the current study is designed to ascertain whether cp-690,550 is associated with qtc prolongation.

the current study is designed to ascertain whether cp-690,550 is associated with qtc prolongation

Eligibility criteria:
inclusion criteria: * healthy male and/or female subjects between ages of 18 and 55 years, inclusive. * body mass index (bmi) of approximately 18 to 30 kg/m2; and a total body weight \>50 kg (110 lbs). exclusion criteria: * use of tobacco- or nicotine-containing products in excess of equivalent of 5 cigarettes per day. * 12-lead ecg demonstrating qtc \>450 msec or other clinically significant abnormalities at screening. * history of risk factors for qt prolongation or torsades de pointes. * pregnant or nursing women; women of childbearing potential unwilling or unable to use an acceptable method of nonhormonal contraception from at least 14 days prior to first dose until completion of follow-up. * use of prescription or nonprescription drugs, vitamins and dietary supplements within 7 days or 5 half-lives (whichever is longer) prior to first dose of trial medication. * any clinically significant infections within past 3 months or evidence of infection in past 7 days.

Keywords: tqt study cp-690 550
use-results surveillance study of harvoni® in japanese patients with chronic genotype 1 hepatitis c virus infection

Conditions: Hepatitis C

Summary: this study will evaluate the safety and efficacy of harvoni® (ledipasvir/sofosbuvir (ldv/sof) fixed-dose combination (fdc)) treatment under real world use in japan. among adult patients with chronic genotype 1 hepatitis c virus (hcv) infection and treated with harvoni in routine clinical use, the primary objective of this study is to evaluate the incidence of adverse drug reactions (adrs) under real world settings.


Eligibility criteria:
key inclusion criteria: * adult patients with chronic genotype 1 hcv infection with or without compensated cirrhosis * patients who are prescribed harvoni key exclusion criteria: * none note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: hepatitis c virus observational post-marketing ledipasvir/sofosbuvir japan
evaluation of portal vein stenting in patients with portal vein stenosis and gastrointestinal cancers

Conditions: Malignant Digestive System Neoplasm

Summary: this study collects information about the safety and effect of portal vein stenting in gastrointestinal cancer patients with portal vein stenosis. this study may help researchers learn how long the portal vein stays open and free from blockage and the effects of portal vein stenting on patients' overall well-being.

primary objective: i. to evaluate the safety and efficacy of portal vein stenting in patients with portal vein (pv) stenosis and gastrointestinal malignancies, including quality of life measurements. secondary objectives: i. stent patency and duration of clinical success related to the intervention. ii. compare the efficacy of portal vein stenting on liver volumes, nutritional status, and laboratory values relative to patients with portal vein stenosis/thrombosis who do not undergo portal vein stenting. outline: patients are assigned to 1 of 2 cohorts. cohort a: patients complete a quality of life (qol) questionnaire at 2-4 weeks and then 6-8 weeks after portal vein stenting procedure. patients' medical records are also reviewed. cohort b: patients' medical records are reviewed retrospectively.

Eligibility criteria:
inclusion criteria: * cohort a: all patients will undergo initial staging and treatment as per the institution standard of care. patients will be considered eligible for porto-mesenteric venous stenting (pvs) if: * there is \> 75% porto-mesenteric venous stenosis in either main portal vein (pv), left pv, right pv, or the superior mesenteric vein (smv), even in absence of symptoms of portal hypertension * patients presented with any degree of vascular narrowing of said vessels and symptomatic portal hypertension including variceal bleeding, refractory ascites, abdominal pain, intestinal edema, or diarrhea after exclusion of tumor-related causes as direct tumor invasion or peritoneal dissemination * cohort b: patients who have thrombosis/stenosis of the main portal vein but who did not undergo stenting
electrical impedance scanning of thyroid nodules prior to thyroid surgery: a prospective study

Conditions: Thyroid Neoplasms; Thyroid Nodules

Summary: patients over the age of 18 with thyroid nodules scheduled for surgery will undergo eis scan. each node will be scanned and graded form 1-5 (1=benign, 5=malignant). results will be compared with final histopathology.


Eligibility criteria:
inclusion criteria: * patients over the age of 18 with thyroid nodules scheduled for surgery. exclusion criteria: * pregnant patients * patients with electrical powered devices (cardiac pacemakers)

Keywords: thyroid neoplasms thyroid nodules electrical impedance scanning
patient's knowledge on their anticoagulating and anti platelet treatment st joseph's hospital)

Conditions: Coagulation Disorder

Summary: oral antigoagulant are used more than 60 years in thrombotic diseases. even they are indispensable, the haemorragic risk is high.that's why it's the main reason of hospitalization for iatrogeny.the complication's reasons are mainly linked to errors of drug intake, drugs interaction and the lack of understanding the treatment.moreover, the antiplatelet agglutening treatment is frequently added to anticoagulant treatment.this increases the haemorragic risk.different means were used to minimize the risk , like inr follow up. the purpose of the study is to evaluate smartphone use to follow the patients'treatment.

two questionnaire via smartphone with 15 days gap.

Eligibility criteria:
inclusion criteria: * patient under ant-thrombotic treatment * hospitalized in vascular medecine service exclusion criteria: * refusing the participation
clinical study of laparoscopic non banded vertical gastroplasty in bariatric surgery

Conditions: Obesity

Summary: evaluation of the laparoscopic approach of the magenstrasse and mill procedure in a prospective study of 100 patients

the laparoscopy is performed under general anesthesia with a 5 ports access under 14mm hg pressure. after opening of the gastrocolic ligament and division of any adhesions between stomach and pancreas a circular opening is performed at the junction of corpus and antrum of the stomach with a circular stapler. a tubular gastric pouch is then created along a calibration tube at the lesser curvature by a vertical stapling starting from the circular opening to the angle of hiss.

Eligibility criteria:
inclusion criteria: * assessment by a multidisciplinary team specialized in bariatric and metabolic surgery including surgeon, endocrinologist, psychologist and/or psychiatrist, dietician * bmi\>40 * bmi\>35 with diabetes or sleep apnea syndrome or hypertension treated with 3 drugs for at least one year * male or female patients between 18 and 75 years of age; fertile female patients must use a reliable contraception method; * no previous bariatric procedure * informed consent given by patient exclusion criteria: * medical contra-indication for a general anesthesia, or abdominal surgery (allergies to anesthetic drugs, cardio-vascular, pulmonary, or renal conditions leading to an unacceptable risk for the procedure * psychological-psychiatric (boulimia, severe depression, psychotic condition) * non stabilized endocrine disorder, with potential interference on weight and/or diabetic condition * unability to understand goal of the study, plan of treatment and follow-up * large hiatal hernia and/or severe esophageal reflux disease * grazer, sweet eater behavior

Keywords: obesity bariatric surgery sleeve gastroplasty laparoscopy