Kornimate/medical-research-clean huggingface dataset:
mind/body medicine and ibd flare-up

Conditions: Ulcerative Colitis

Summary: ulcerative colitis is an inflammatory bowel disease that is a life-long, relapsing disabling disorder. current treatments for ulcerative colitis are not satisfactory. most medications provide only partial relief, are not successful for at least 30% of patients, and have major negative side effects. mounting evidence indicates that stress is one of the important triggers that activates symptoms of ulcerative colitis and therefore causes flare-up. the primary aim of this study is to see if either of two 8-week mind-body courses has an effect in reducing stress and affecting the course and severity of uc. hypotheses: stress causes ulcerative colitis flare-up and stress reduction will prevent ulcerative colitis flare-up.

methods: we will enroll 100 subjects in a phase i/iia randomized, double-blind, placebo-controlled trial. subjects will be assigned to one of two mind/body courses, each of which will be held once a week for 8 consecutive weeks. each class will last 1.5-2 hours.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of moderately severe ulcerative colitis * age 18-70 * must have inactive disease at the time of recruitment, with at least one documented disease flare-up within the past 2 years. * must be on either no ibd medication or have been on a stable dose of any of the following medications for the specified amount of time: mesalamine or sulfasalazine for at least 6 weeks; remicade for at least 10 weeks; imuran or mercaptopurine at stable and unchanged dose for at least 8 weeks. exclusion criteria: * active ulcerative colitis or daily rectal bleeding for 7 days * taking oral steroids within 30 days of enrollment, topical agents (steroids or 5-asa) within 14 days,immunomodulators such as methotrexate or imuran/6-mp and infliximab within 90 days * history of colon resection * antibiotics use within the previous 14 days * pregnant or lactating women * significant chronic disorders like severe cardiac disease (ny functional state score\>3), renal disease (creatinine\>3 mg/dl), pulmonary disease (shortness of breath at rest or need for oxygen use), active infection, or other organ system disease requiring medical visits \> 3 times /year

Keywords: ulcerative colitis ibd flare-up stress
exploring the distribution patterns and infrared characteristics of force-sensitive acupoints in different lumbar nerve segments in patients with ldh based on "press quickly" theory

Conditions: Lumbar Disc Herniation

Summary: utilizing the "responsive acupoint palpation" technique and infrared thermography, we investigated the distribution patterns of pressure-sensitive acupoints across different lumbar spinal segments in patients with lumbar disc herniation (ldh). methodology: the finger tps tactile pressure measurement system was employed to conduct sensitivity examinations on the acupoints of the l1\~l5 lumbar spine in 80 ldh patients (group 1) and 80 healthy individuals (group 2), applying a standardized force of 60n. when a sensation of comfort was elicited, the points were marked on a human cutaneous nerve segment map. we then utilized infrared thermography to collect and compare the temperature differences of the top 10 most frequently responsive acupoint areas in the experimental group against those in the control group.


Eligibility criteria:
inclusion criteria: * age range of 18 to 65 years, regardless of gender. * radiological confirmation of central type l4\~l5 intervertebral disc herniation. * meeting the diagnostic criteria for lumbar disc herniation, primarily manifesting as lower back pain, radicular pain, and numbness or weakness in the lower limbs, with imaging findings consistent with neurological localization. * patients in the non-acute phase of mild to moderate pain and functional impairment (onset more than 2 weeks ago), with a visual analog scale (vas) score greater than 4 points and a japanese orthopaedic association (joa) score less than 15 points. * no consumption of analgesics, neurotrophic drugs, or sedatives, and no systemic treatment in the past week. * willing participants in the study who have signed an informed consent form. exclusion criteria: * concomitant internist and gynecological diseases that can cause lower back pain, such as nephritis, urinary tract stones, gynecological inflammations, and uterine pathologies. * individuals with severe primary diseases of the cardiovascular, cerebrovascular, liver, kidney, etc. * patients with neurosis or psychiatric disorders, or those with a history of cranial trauma or coma. * patients with primary or ankylosing sciatica. * individuals with concomitant lumbar spondylolisthesis. * patients with lumbar spine tumors or tuberculosis. * individuals with consciousness disorders, severe impairments in vision, hearing, or speech, or any other condition that prevents the completion of a health assessment.

Keywords: lumbar disc herniation press quickly point-press method pressure-sensitive acupoints infrared thermal imaging
the added value of hybrid functional anatomical imaging pet-ct and spect-ct in patients treated with y-90 sirt for liver malignancies

Conditions: Primary Liver Tumor, Metastatic Liver

Summary: patients cohort is composed of 50 consecutive patients both male and female with hepatic malignancies, refered to our nuclear medicine department in the process of radioembolization between january 2010- august 2015. 26 of the patients were examined with tc99-maa and spect-ct and 24 patients were examined with tc99-maa , spect-ct and pet-ct. our study protocol was as follows: 1. collection of anamnestic data 2. calculation of liver tumor volume with quantification software 3. evaluation of the liver tumor involvement 4. evaluation of liver to lung shunt 5. calculation dose of sirtex 6. y90 imaging 7. follow up

the description of the various stages that the patient goes through sirtex treatment in the department of nuclear medicine and their roll in the study is as following: the first stage is dedicated to the evaluation of the patient's illegibility for the treatment. 1. in angiography department 2. in nuclear medicine department assessment of liver-lung shunting (planar images). followed by spect-ct of the upper abdomen. spect with low dose ct is used to identify a leak to the stomach, duodenum and mesentery, as well as to assess uptake of tc-99m-maa in tumor lesions. in order to increase spect-ct resolution and sensitivity we co-registrated spect-ct with diagnostic ct provided from previous contrast enhanced ct or pet-ct. in this procedure, the low dose ct is used as bridge between diagnostic ct and the functional imaging spect. 3. calculation dose of sirtex therapy. at this stage the purpose of the study will be to investigate the added value of spect-ct in the estimation of tc-99m-maa uptake in tumor lesions. the second stage is dedicated to the assessment y-90-sirtex uptake in liver tumors and to exclude extra hepatic leak. several hours after treatment patients perform spect-ct using brummshtrullung emission or pet-ct with the peak zr-90. at this stage , in our study, we will compare liver lesions uptake of tc-99m-maa in the spect-ct to lesions uptake of y-90 -sirt spect/pet-ct as well as to assess if spect-ct withtc-99m-maa may be used as a predictor of y-90-sirtex uptake in liver lesion. does spect-ct with tc-99m-maa change patient managment. the third stage of the study is the collection and monitoring of post treatment outcome data.

Eligibility criteria:
inclusion criteria: * 1. age ≥ 18. 2. patients with malignancy of the liver (metastasis or primary tumor) who were treated with y90 sirt and were refered to the nuclear medicine department for a pet-ct. exclusion criteria: * 1. age \< 18. 2. pregnant woman 3. children and legally incompetent.
sufficient treatment of peripheral intervention by cilostazol

Conditions: Arteriosclerosis Obliterans

Summary: recently, nanto et al. reported that cilostazol effectively prevented restenosis in a retrospective analysis of 121 femoropopliteal artery lesions in percutaneous transluminal angioplasty (pta) patients who had undergone pta. in a prospective 3-year follow-up study in 127 patients with similar diseases, the patency rate was significantly higher in the cilostazol group than in the ticlopidine group. it was also found that cilostazol markedly inhibited restenosis during the first 1-year period following endovascular therapy when restenosis is most frequently observed. in addition, there have been sporadic reports that cilostazol was effective in preventing post-stenting restenosis in the coronary artery area. based on these results, this multicenter study is going to be conducted to prospectively evaluate the usefulness of cilostazol in lower limb endovascular therapy.


Eligibility criteria:
patient criteria: * chronic arteriosclerosis obliterans afflicting the femoropopliteal artery area\* * patients who can be monitored for at least 2 years after surgery lesion criteria: * angiographically-confirmed new significant superficial femoral artery stenosis or occlusive lesions that are 30 cm long or less if stented * at least 1 arterial runoff below the knee; stenosis lesions not limiting flow may be included. * occlusive lesions may be included. exclusion criteria: * patients with or at risk of hemorrhagic complications or patients with bleeding tendency * patients with congestive cardiac failure * patients with a drug-eluting stent * patients with acute lower limb ischemia * patients with creatinine of 2 mg/dl or more(without dialysis) * patients with a history of serious adverse reaction such as leukopenia, hepatic dysfunction, or renal dysfunction, or hypersensitivity to any component of the study drug. lesion criteria: * remnant inflow * severe calcification * no arterial runoff below the knee

Keywords: endovascular therapy restenosis cilostazol femoropopliteal artery lesions chronic arteriosclerosis obliterans afflicting the femoropopliteal artery area
risk factors for portosinusoidal vascular disease in kidney transplant recipients:

Conditions: Porto-Sinusoidal Vascular Disease

Summary: to look for the factors of exposure present prior to the onset of porto-sinusoidal vascular disease (psvd) and which can lead to the occurrence of psvd after renal transplantation, and therefore to consider the identification of risk factors, in order to prevent or detect early signs of portal hypertention in predisposed patients and improve their prognosis.

porto-sinusoidal vascular disease (psvd) is a heterogeneous clinico-pathological entity characterized by alterations in small liver vessels. the most common is known as "nodular regenerative hyperplasia (nrh)". patients with psvd especially nrh can developed portal hypertension. an acute portal thrombosis occurs in 1/3 of patients at five years. in case of portal hypertension, 10 years survival decreases down to 56 to 82%. de novo nrh has been described after liver transplantation (1 to 1.4% in adults, 8.2% in kids), and also in small series of kidney, cardiac and bone marrow transplantation. prevalence is estimated to be 0.5% after kidney transplantation. several risks factors have been related to psvd (infections, immune-mediated disorders, haematological diseases, prothrombotic disorders, drugs such as azathioprine, genetic diseases). in transplantation, mechanical vascular factors, drugs, virus, immunogenetic and immunologic factors have been suggested, but none of them are well established. the study aims to determined risk factors which can lead to psvd in kidney transplant recipients, in order to prevent or to early detect portal hypertension and improve the prognosis of these patients. a case-control multicentric retrospective study will be done to compare adult kidney transplant recipients with psvd with or without portal hypertension, to adult kidney transplant recipients without evidence for psvd (matched according to the date of kidney transplantation of the case ± 2 years), and to non-transplanted adults with psvd. kidney transplant cases and controls will be recruited from french hepatogastroenterology and nephrology units. psvd non transplanted controls will be recruited from the beaujon hospital database dedicated to liver vascular diseases.

Eligibility criteria:
inclusion criteria: * psvd (between january 2000 and december 2021) after kidney transplantation or * kidney transplantation without psvd or * psvd without kidney transplantation exclusion criteria: * liver cirrhosis * transplanted from an other organ * thrombocytopenia and/or abnormal liver tests and/or hepatic dysmorphism and/or portal hypertension signs
tranexamic acid in dacryocystorhinostomy

Conditions: Nasolacrimal Tract Obstruction

Summary: single dose tranexamic acid (ta) before dacryocystorhinostomy (dcr) operation: a prospective, double blind, placebo controlled study. the study hypothesis: ta in dcr might reduce the intraoperative and postoperative bleeding in dcr surgery, and might reduce the duration of the surgery.


Eligibility criteria:
inclusion criteria: * obstruction of nasolacrimal pathway * eligible for dcr surgery * 18 years of age or older exclusion criteria: * warfarin treatment * renal insufficiency * pregnancy * mental retardation * tendency to bleed * thromboembolic disease * thrombophilia

Keywords: bleeding dacryocystorhinostomy operative duration
activating older people after a hip fracture

Conditions: Hip Fractures

Summary: the main aim of this study is to determine if the activehip tele-rehabilitation mobile application improves the functional level and the quality of life of patients who undergone hip surgery after a fracture. the second aim is to determine if the activehip intervention reduce the anxiety, stress and burden of the caregivers.


Eligibility criteria:
inclusion criteria: * have hip fracture surgery * age equal to or greater than 65 years * are allowed weight-bearing at 48 hours after surgery * had a high pre-fracture functional level the week before the fracture (functional independence measure \[fim\] index scored more than 90 points) * have an informal or family caregiver who has the ability to access the internet to use the app activehip+ * basic management of the mobile phone * have signed an informed consent. exclusion criteria: * presence of low cognitive level (pfeiffer test score lower than 4 points) * being dependent on the activities of daily living before the hip (functional independence measure \[fim\] index scored less than 60 points) * being institutionalized * post-surgery complications * terminal disease * age under 65 years

Keywords: tele-rehabilitation occupational therapy physiotherapy physical exercise function quality of life informal caregiver burden information and communication technologies
effect of a combined use of mosquito repellent and insecticide treated net on malaria in ethiopia

Conditions: Malaria; Mosquito Repellent; Long Lasting Insecticidal Nets

Summary: the combined use of a mosquito repellent and long lasting insecticidal nets (llins) by household members would result in a 40% reduction in malaria prevalence compared with households that only use llins.

it has been recognized that the use of malaria preventive measures in combination with llins could improve the effectiveness of nets in preventing the disease. this study examined the effect of a combined use of mosquito repellent (i.e., buzz off) and llins on malaria prevalence in an area of unstable and seasonal malaria transmission.

Eligibility criteria:
inclusion criteria: * all volunteer household members exclusion criteria: * infants less than two months * not in the study area

Keywords: malaria mosquito repellent llins
electroconvulsive treatment followed by cognitive control training

Conditions: Depressive Episode; Electroconvulsive Therapy; Cognitive Remediation

Summary: major depressive disorder (mdd) is worldwide one of the most prevalent and disabling mental health conditions. electroconvulsive therapy (ect) is a safe and effective treatment even though 6-month relapse rates are high. cognitive side effects of ect, such as reduced cognitive control, might trigger mechanisms that increase relapse in patients. as such, cognitive control training (cct) holds promise as a non-pharmacological strategy to improve long-term effects of ect (i.e., increase remission, and reduce depression relapse).

eighty-eight participants aged between 18-70 years with major depressive disorder who start electroconvulsive treatment (ect) will be included in this randomized controlled trial (rct). following (partial) response to ect treatment (at least a 25% reduction of clinical symptoms), participants will be randomly assigned to a computer based cct or active placebo control. a first aim of this rct is to assess the effects of cct compared to an active placebo condition on depression symptomatology, cognitive complaints, and quality of life. secondly, participants will be monitored every two weeks for a period of six months following cct/active placebo, allowing the detection of potential relapse of depression. thirdly, the investigators will assess participant evaluation of the addition of cognitive remediation to ect using qualitative interview methods (satisfaction, acceptability and appropriateness). finally, in order to further advance the understanding of the mechanisms underlying effects of cct, exploratory analyses may be conducted using facial video footage collected during the cct/active control phase of the study.

Eligibility criteria:
inclusion criteria: * aged between 18 and 70 years old * current major depressive episode with treatment resistance * eligibility and consent for ect treatment * ability to provide consent to study exclusion criteria: * neurodegenerative disorder or montreal cognitive assessment (moca) \< 18 * catatonia * schizophrenia * alcohol use disorder in previous year * prior ect treatment * insufficient computer knowledge or analphabetism

Keywords: cognitive control training
entire-body pet scans for multiple sclerosis

Conditions: Multiple Sclerosis

Summary: to evaluate whether an entire-body positron emission tomography (pet) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (ms) patients.

to collect exploratory data using the most recent pet-ct scanners with their increased detection sensitivity and spatial resolution for the evaluation of f18-florbetapir radiopharmaceutical uptake in the nervous system of the entire body with special attention to correlation of radiotracer activity levels in the myelinated, demyelinated, or remyelinated white matter of multiple sclerosis (ms) patients compared to normal healthy subjects. the pilot study will be conducted on 20 participants as a clinical research trial of pet amyloid and myelin imaging with the primary objective of identifying possible differences in f18-florbetapir radiotracer activity for ms patients compared to normal healthy subjects, and the secondary objective of monitoring psychological health of those participants who elect to be informed of imaging results and who complete a panel of psychometric scales before and after imaging results disclosure.

Eligibility criteria:
inclusion criteria: * multiple sclerosis (ms) patients diagnosed by a credentialed neurologist experienced with care of multiple sclerosis patients. * normal healthy subjects. * willing and able to lie motionless on the pet-ct scanner bed for at least 10 minutes and up to 20 minutes for the duration of the pet-ct medical imaging scan. exclusion criteria: * any additional complicating medical illness other than ms including any other neuropsychiatric illness unrelated to ms diagnosed prior to the onset of initial symptoms of ms. * pregnancy or breast feeding. * diabetes or other metabolic-endocrine disorders. * any known concomitant acute infection. * history of metastatic or locally invasive cancer. * recent surgery, chemotherapy or radiation therapy.

Keywords: multiple sclerosis entire-body pet imaging
a comparison of olopatadine and fluticasone in patients with allergic conjunctivitis

Conditions: Conjunctivitis, Allergic

Summary: to compare the clinical efficacy of olopatadine and fluticasone in a 3-week single center, double-masked, randomized, placebo controlled parallel treatment conjunctival allergen challenge (cac) study in patients with allergic conjunctivitis

study will evaluate the efficacy of nasal anti-allergic therapy compared to ocular anti-allergic therapy in the prevention of ocular allergic symptoms.

Eligibility criteria:
inclusion criteria: * at least 18 years of age \& either sex, any race * willing and able to follow all instructions and attend all study visits * positive history of ocular allergies * reproducible positive ocular allergic reaction induced by conjunctival allergen challenge exclusion criteria: * have planned surgery during trial period * female currently pregnant, planning a pregnancy, or lactating * use of disallowed medications

Keywords: allergic conjunctivitis allergic rhinoconjunctivitis
study on how pre-workout supplements affect shooting accuracy in trained basketball players

Conditions: Athletic Performance

Summary: basketball is a popular team sport where athletes score points by successfully shooting the ball into the basket. accuracy in shooting is crucial for players to score points effectively. pre-workout supplements (pws) have garnered interest from athletes and fitness enthusiasts due to the purported synergistic action of their ingredients which, when consumed before training, may help improve athletic performance. the acute effect of pws or similar on the shooting accuracy of basketball athletes has not yet been investigated. therefore, this study aimed to investigate the acute effect of a caffeine-based pws (containing caffeine, creatine, β-alanine, citrulline malate, and bcaas) on the stationary free throw, two-point, and three-point shooting accuracy in basketball players.

according to a randomized, double-blind, crossover, research design, 12 active and well-trained male basketball players will be recruited. the sample will participate in three treatments: 1) no supplement; 2) pws and 3) placebo (pl). three field-based basketball shooting tests (stationary free throw, stationary two-point, and three-point shots) will be performed to assess shooting accuracy . during the first visit, participants who met the inclusion criteria will visit our laboratory for health assessment/ screening. at the same time, after receiving a detailed verbal explanation and written instructions from our team's registered nutritionist, participants will be advised to follow the exact same diet one day before the subsequent trials, one week apart. during the second visit, all participants will arrive at the basketball court to execute the shooting tests in the following order: 1) the stationary free throw shooting test (s1p), 2) the stationary two-point shooting test (s2p), and 3) the stationary three-point shooting test (s3p). one week later, during the third visit, all players will return to the same basketball court. they will receive a single dose either pws or pl 30 minutes prior to the evaluations. participants and researchers will all blinded as to the type of supplement consumed. following that, they will complete the same measurements in the same order as in the second visit. a week later all procedures will be repeated, and participants will receive the alternative supplement depending on randomization.

Eligibility criteria:
inclusion criteria: 1. male participants, 18+ 2. absence of drugs, abuse or medications, which are known to affect the shooting accuracy exclusion criteria: 1. restraining orthopedic/neuromuscular issues 2. caffeine hypersensitivity 3. consumption of more than three servings of coffee per day 4. use of any supplement or steroids prior to the study 5. use of creatine, β-alanine, citrulline malate or bcaa-protein supplementation at least six months before the initiation of the study