Kornimate/medical-research-clean huggingface dataset:
high-intensity exercise training in patients with post-infarction heart failure

Conditions: Heart Failure; Myocardial Infarction

Summary: introduction: moderate-intensity endurance-training is known to reduce symptoms, increase exercise tolerance, and improve quality of life in patients with chronic heart failure. the training benefits have mainly been attributed to adaptations in the peripheral circulation and skeletal muscle rather than to adaptations in cardiac performance. however attenuation of left ventricular (lv) remodelling has been documented in some studies. the effects of high- vs. moderate exercise-intensity on lv-remodelling and endothelial function in patients with post-infarction heart failure are not definitively established and were studied in the present study. methods: patients with post-infarction heart failure (45-87 yrs, 22-males, 5-females, all received b-blockers and ace-inhibitors, ef 29%, peak oxygen uptake 13 ml/kg/min) were randomized to 12-weeks, 2-3 times per week, of either moderate exercise-intensity (70% of peak heart rate), high-intensity interval-training (95% of peak heart rate) or to a control group that received advise from their regular doctors. patients in the two exercise-groups covered similar distance on the treadmill at each exercise-session so that only exercise-intensity differed; i.e. the duration of exercise was longer in the moderate-intensity group. ultrasound was used to assess lv-dimension and function (including tissue doppler imaging, tdi) and endothelial function in the brachial-artery.


Eligibility criteria:
inclusion criteria: post-infarction heart failure and optimal treatment (ace-inhibitors, beta-blockade) exclusion criteria: not able to walk on a treadmill, unstable angina, participating in another experiment, serious arrhythmia

Keywords: interval training endothelial dysfunction aerobic capacity exercise
cpap treatment and postoperative outcomes in patients with rheumatic valvular heart disease

Conditions: Rheumatic Valvular Heart Disease; Obstructive Sleep Apnea

Summary: the prevalence of osa (obstructive sleep apnea，osa) is 2%-4% in general population and 16%-47% in surgical-heart failure patients. our previous study found that osa was associated with the increasing incidence of perioperative adverse events.the continuous positive airway pressure (cpap), as the standard treatment for osa, is extensively applied clinically. the previous study reported that postoperative ahi was reduced and spo2 was increased by cpap treatment. however, whether cpap treatment can improve osa postoperative and related adverse events or not in patients with rheumatic valvular heart diseases (rvhd) were not reported.the purpose of this study is to observe the effective of preoperative cpap on postoperative sleep parameters and adverse events, such as ahi changes, duration of icu stay and duration of mechanical ventilation.

between december 1, 2017 and june 30 2019, 200 patients with chronic heart failure caused by rheumatic valvular heart disease waiting for heart valve replacement in department of cardiovascular surgery were screened for obstructive sleep apnea (osa) by full-night polysomnography (psg). of them, 30 osa patients were enrolled and randomly received cpap treatment and non-cpap treatment (15:15). the cpap treatment group received both baseline and cpap treatment. the full-night cpap treatment was conducted from 21:00 pm to 6:00 am for 7 days preoperatively. the non-cpap treatment group received baseline treatment. preoperative sleep parameters (ahi, mean and lowest spo2) and clinical evaluations including nyha class, electrocardiographic, echocardiographic, arterial blood gas analysis findings, baseline medication, and 6-minute walk test were recorded. operation related parameters such as duration of operation, duration of cardiopulmonary bypass and bleeding volume were recorded. postoperative adverse events such as duration of icu stay, postoperative duration of mechanical ventilation, pacemaker use, complicated infection and reintubation are recorded. a psg was re-examined before discharge from hospital. the changes of ahi, mean and lowest spo2 between pre- and post-operative psg parameters were calculated. the operation related parameters, postoperative adverse events and the changes of sleep parameters were compared between cpap and non-cpap patients.

Eligibility criteria:
inclusion criteria: 1. patients aged 18-75 years. 2. patients with rheumatic valvular heart disease. 3. patients combined with obstructive sleep apnea (apnea-hypopnea index \>=5/h). 4. received heart valve replacement surgery. 5. the enrolled patients having received patients' informed consent. exclusion criteria: 1. history of stroke or clinical signs of peripheral or central nervous system disorders. 2. history of chronic obstructive pulmonary disease or asthma. 3. enrolment in another clinical study.

Keywords: obstructive sleep apnea heart valve replacement cpap treatment
an ultrasound imaging technique to measure tumors in people with pancreatic ductal adenocarcinoma (pdac) or gastrointestinal (gi) adenocarcinoma

Conditions: Pancreas Cancer; Gastrointestinal Adenocarcinoma

Summary: the purpose of this study is to see if ultrasound images that are analyzed by a special computer program can be used to measure the size of pdac tumors in the liver as accurately as ct scans that involve contrast material (also called contrast-enhanced ct scans). all participants in this study will have pancreatic ductal adenocarcinoma (pdac) that has spread (metastasized) to the liver, and all participants will be scheduled for a routine ct scan that will measure their cancer.


Eligibility criteria:
inclusion criteria: * male and female patients, 18 years of age or older * confirmed diagnosis of pdac or gi tract adenocarcinoma metastatic to liver * scheduled for imaging with contrast enhanced ct exclusion criteria: * inability to tolerate intravenous contrast medium * all liver metastases ≤ 10 mm in maximal diameter on the contrast enhanced ct used for comparison to the planned research ultrasound * multiple confluent liver metastases or tumor burden \> 50% of the liver as estimated by a radiologist

Keywords: sonographic assessment tumor volumes for response 21-138
canola oil multi-centre intervention trial ii

Conditions: Cardiovascular Disease; Diabetes; Metabolic Syndrome

Summary: the objectives of the study are to examine the health benefits of dietary canola oils on body composition, specifically on android fat, and weight management. comit ii will also include analysis of faes to elucidate the mechanisms by which canola oil may be modifying body composition. measurement of endothelial function, inflammatory, adiposity, and insulin sensitivity biomarkers will be done to determine the positive health impact of the changes in body composition achieved through canola oil consumption.

the proposed multi-center clinical trial would engage the same collaborative team that successfully operationalized comit i, namely, the richardson centre for functional foods and nutraceuticals (rcffn) at the university of manitoba (winnipeg, manitoba, canada), the l'institut des nutraceutiques et des aliments fonctionnels (inaf) at laval university (quebec city, quebec, canada), the department of nutritional sciences at the pennsylvania state university (university park, pennsylvania, usa), the risk factor modification centre at st. michael's hospital (toronto, ontario, canada). st. boniface hospital research (winnipeg, manitoba, canada) will be an additional clinical trial site. the proposed comit ii research program will proceed as a double blind, randomized crossover study consisting of three treatment phases of six weeks, each separated by a 6-week washout period. participants will consume a fixed composition of a precisely controlled basal, weight-maintaining diet (35% energy from fat, 50% carbohydrate and 15% protein) supplemented with the following treatment oils: (a) regular canola oil, (b) high stability/ high oleic canola oil and (c) a typical "western diet" fat intake as a control treatment comprised largely of saturated fat with substantial levels of omega-6 linoleic acid, common to current north american intakes. treatment oils will be isocalorically incorporated into fruit smoothies made with milk and consumed at breakfast and supper. the clinical segment of comit ii is expected to be completed by the mid to end of the second year, with sample analyses to be completed by the end of year three.

Eligibility criteria:
inclusion criteria: - waist circumference ≥94 cm for men and ≥80 cm for women participants must meet at least one of the following secondary inclusion criteria: * fasting blood glucose of ≥ 5.6 mmol/l * triglycerides (tg) ≥1.7 mmol/l * hdl cholesterol (hdl) \<1 mmol/l (males) or \<1.3 mmol/l (females) * blood pressure ≥130 mmhg (systolic) and/or ≥85 mmhg (diastolic). exclusion criteria: * kidney, or liver disease, or unstable thyroid disease * diabetes mellitus * smokers * those consuming \>1 alcoholic beverage a day for women and \>2 for men. * any participant taking medication known to affect lipid metabolism or endothelial function
efficacy of snap on symptomatic arrhythmia

Conditions: Arrhythmia

Summary: participants in the snap arm were instructed to undertake once-day recording and transmission of a 30-second single-lead iecg trace to a secure server, plus additional submissions if symptomatic over a 3-month period. snap traces were analyzed by an automated analysis software and cardiologists. clinical review and appropriate care was arranged for those clinically significant arrhythmia. patients in the rc group were followed up as normal methods including ecg, holter.

individuals with symptomatic arrhythmia without known arrhythmia were recruited. participants were required to have access to the internet via wifi and to be able to operate the snap system after simple instruction. written consent was obtained, and eligible participants were randomized (1:1) to an intervention (snap) group or rc group.

Eligibility criteria:
inclusion criteria: * symptomatic arrhythmia exclusion criteria: * can not use the snap instrument and sign informed consent

Keywords: snap symptomatic arrhythmia diagnosis follow-up
3-dimensional versus 2-dimensional laparoscopy of ovarian cyst

Conditions: Laparoscopy

Summary: lack of depth perception and spatial orientation are drawbacks of laparoscopic surgery. the advent of the three-dimensional (3d) camera system enables surgeons to regain binocular vision. the aim of this study was to gain subjective and objective data to determine whether 3d systems are superior to two-dimensional (2d) systems in terms of surgical outcomes.

elective laparoscopic ovarian cystectomy is established as the treatment of choice for benign ovarian cysts. the advantages of laparoscopic surgery over conventional open surgery are less pain, shorter recovery time, shorter hospital stay, and consequently faster return to normal activity as well as better cosmetic effects. however, laparoscopic surgery is more challenging compared with open surgery, partly because surgeons must operate in a three-dimensional (3d) space through a two-dimensional (2d) projection on a monitor, which results in loss of depth perception and consequently more cognitive workload on the surgeon. in traditional 2d laparoscopic procedures, the surgeon has to mentally transform and process the 2d image into a 3d image using motion parallax through movement of the laparoscope, relative position of instruments, and shading of light and dark. during the past 3 decades, 3d imaging systems have been introduced in and attempt to improve in-depth perception and spatial orientation during minimally invasive surgery. the anticipated advantages for the surgeon are greater accuracy and speed in manual skills, translating to decreased operative time, a reduced learning curve, and enhanced safety. nevertheless, studies, to date, examining the potential advantages and disadvantages of 3d versus 2d imaging systems have produced contradictory results. moreover, there have been no studies exploring the advantage of 3d imaging system in patients undergoing laparoscopic ovarian cystectomy. the aim of this study was to gain subjective and objective data to determine whether 3d imaging systems in the treatment of ovarian cyst are superior to 2d systems in terms of surgical outcomes.

Eligibility criteria:
inclusion criteria: * age between 19 and 48 years * american society of anesthesiologists physical status (asaps) classification i-ii * absence of pregnancy at the time of surgery. exclusion criteria: * any suspicious finding of malignant ovarian diseases * any concomitant diseases requiring uterine or upper abdominal surgery * unavailability of the surgical recording equipment for laparoscopic procedure * post-menopausal status
safety and effectiveness of jetstream atherectomy system (j-supreme ii)

Conditions: Peripheral Arterial Disease

Summary: the purpose of this study is to evaluate the safety and effectiveness of the jetstream atherectomy system for the treatment of japanese patients with symptomatic occlusive atherosclerotic lesions in native superficial femoral artery (sfa) and/ or proximal popliteal arteries (ppa).

a prospective, multicenter, single-arm trial evaluating the safety and efficacy of the jetstream atherectomy system in the treatment of symptomatic occlusive atherosclerotic lesions ≤150 mm in length located in the femoropopliteal arteries in subjects with symptoms classified as rutherford categories 2-4.

Eligibility criteria:
inclusion criteria: * chronic, symptomatic lower limb ischemia defined as rutherford categories 2-4 * stenotic, restenotic or occlusive lesion(s) located in the native sfa and/or ppa of which meet the following criteria: * severely calcified lesions with degree of stenosis ≥70% * vessel diameter ≥3.0 mm and ≤6.0 mm * total lesion length (or series of lesions) ≤150 mm exclusion criteria: * target lesion/vessel with in-stent restenosis * history of major amputation in the target limb * subject has a history of coagulopathy or hypercoagulable bleeding disorder * subject with untreatable hemorrhagic disease or platelet count \ 600,000mm3 as baseline assessment. * history of myocardial infarction, or stroke/cerebrovascular accident (cva) within 6 months prior to study enrollment * unstable angina pectoris at the time of the enrollment * septicemia at the time of enrollment * presence of other hemodynamically significant outflow lesions in the target limb requiring a planned surgical intervention or endovascular procedure within 30 days after the index procedure * presence of aneurysm in the target vessel * acute ischemia and/or acute thrombosis of the sfa/ppa prior to the index procedure * perforated vessel as evidenced by extravasation of contrast media prior to the index procedure

Keywords: superficial femoral artery proximal popliteal artery endovascular therapy atherectomy
correlation between pulmonary functions and physical fitness in children with β-thalassemia

Conditions: β-Thalassemia; Pulmonary Function; Physical Fitness

Summary: the aims of this study are: 1. to determine the correlation between pulmonary functions and physical fitness in children with β-thalassemia. 2. to differentiate between different types of b-thalassemia in both pulmonary functions and physical fitness

cohort study: cross-sectional design a) subjects: sample size estimation will be carried out to determine the recruited number of children selected randomly. each participant's caregiver will sign a consent form authorizing the participation of their children in this study. they will be selected based on the following: inclusion criteria: * age range from 6 to 12 years * children with β-thalassemia major and intermediate of both sex and control healthy children of both sex * they can follow instruction exclusive criteria: children will be excluded from the study if they have: * defined cardiovascular or respiratory disorders. * renal failure * visual or hearing impairment, mentally retarded children * myocardial infarction within the last month * unstable angina, recent thoraco-abdominal surgery * thoracic or abdominal aneurysm or current pneumothorax ii) materials 1. for evaluation of pulmonary functions the measurements that are made include forced expiratory volume in one second (fev1), forced vital capacity (fvc) and the ratio of the two volumes (fev1/fvc). 2. for evaluation of physical fitness aerobic capacity and endurance by 6-minute walk test , 3 minutes step test and energy expenditure bmi balance pediatric balance scale

Eligibility criteria:
inclusion criteria: * • age range from 6 to 12 years * children with β-thalassemia major and intermediate of both sex and control healthy children of both sex * they can follow instruction exclusion criteria: * • defined cardiovascular or respiratory disorders. * renal failure * visual or hearing impairment, mentally retarded children * myocardial infarction within the last month * unstable angina, recent thoraco-abdominal surgery * thoracic or abdominal aneurysm or current pneumothorax
the effect of intravenous lidocaine on allodynia

Conditions: Pain

Summary: the purpose of this study is to study if lidocaine, given intravenously, reduces pain.

clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.

Eligibility criteria:
inclusion criteria: * chronic regional pain syndrome diagnostic criteria by the work safe bc. vi exclusion criteria: * history of substance abuse * other medications: crps patients are expected to be treated for chronic pain, whether the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis. * coronary artery disease (cad): unstable * congestive heart failure (chf): unstable * heart arrhythmia: symptomatic * chronic obstructive pulmonary disease (copd) * lidocaine allergy * diagnostic and statistical manual of mental disorders (rev iv): axis i: common axis i disorders include depression, anxiety disorders, bipolar disorder, adhd, and schizophrenia. axis ii: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation. * presence of contraindications for mri * presence of electronically, magnetically, and mechanically activated implants * electronically, magnetically, and mechanically activated implants * ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators * cardiac pacemakers * metallic splinters in the eye * ferromagnetic haemostatic clips in the central nervous system (cns) * claustrophobia * pregnancy

Keywords: lidocaine allodynia chronic regional pain syndrome pain
impact of placement of a diazepam suppository on early postoperative pain following pelvic reconstructive surgery

Conditions: Postoperative Pain

Summary: this is a randomized double-blinded placebo controlled trial to examine the use of rectal diazepam suppositories after major vaginal pelvic organ prolapse surgery will decrease postoperative pain in the interval between 3.5 and 6 hours postoperative compared to placebo.

hysterectomy is the most common major surgery performed in gynecology. minimally invasive techniques for hysterectomy including vaginal and laparoscopic routes are preferred over the more invasive abdominal procedures, which are associated with more pain, longer hospital stays, and increased rates of complications. research has continued to provide evidence that same day discharge (sdd) after hysterectomy is safe, cost effective, and well received by patients. pain is a common concern for patients undergoing major pelvic surgery and pain must be well controlled prior to discharge home. rectal administrations of medications are an attractive option postoperatively in patients desiring sdd. rectal analgesia avoids 1st pass metabolism in the liver, leading to increased bioavailability of many medications and fewer side effects such as nausea and vomiting. the purpose of the study is to investigate whether perioperative administration of a rectally administered diazepam suppository results in improved pain scores between 3.5 and 6 hours postoperatively in patients undergoing major vaginal pelvic reconstructive surgery.

Eligibility criteria:
inclusion criteria: * english speaking, able to understand informed consent and questionnaires * vaginal hysterectomy with vaginal vault suspension by one of the providers in the division of urogynecology and reconstructive pelvic surgery at trihealth, inc. * with or without anterior and posterior repairs * with or without concomitant procedure for stress urinary incontinence * with or without removal of fallopian tubes or ovaries exclusion criteria: * use of mesh for prolapse repair * robotic, laparoscopic, or open technique used for prolapse repair and/or hysterectomy * concomitant procedure done by an additional surgeon * concomitant anal sphincteroplasty or rectovaginal fistula repair * contraindication to use of diazepam: * allergy to diazepam or other benzodiazepines * acute narrow-angle glaucoma * untreated open-angle glaucoma * myasthenia gravis * severe respiratory impairment * severe hepatic impairment * history of chronic pelvic pain receiving medical care * daily use of medication for pain: nsaid, tylenol, opioid, gabapentin, and/or amitriptyline * pregnancy
comparison of the 'ctr' ratio with standard haemostasis parameters in the follow-up of patients undergoing heparin therapy

Conditions: Venous Thromboembolic Disease

Summary: the quantra(r) hemostasis analyzer (stago) is a recent addition to the family of global hemostasis tests. it uses ultrasound-based technology to characterize the viscoelastic properties of a whole blood sample during coagulation. the qplus(r) cartridge consists of independent channels, each containing different reagents that provide parallel measurements of 6 parameters. this global test takes into account cellular elements such as platelets and red blood cells in clot formation, and also explores fibrinolysis. in addition, this test is of particular interest in delocalized biology, i.e. at the patient's bedside, and avoids the time-consuming laboratory centrifugation stage required for routine analyzers. in practice, this test has been developed to monitor haemostasis in patients who may present with a range of coagulopathies of various etiologies, but also in the management of haemorrhagic patients, in order to adapt the administration of blood products in particular. the quantra (r) analyzer could therefore be of interest since it could be deployed in overseas operations to manage war casualties. recent studies (eactaic-iccva congress, october 2021) have shown that there is a good correlation between anti-xa activity and the ctr (coagulation time ratio) parameter of the quantra cartridge qplus (tm), suggesting that this automated system could be used to manage anticoagulant therapy.


Eligibility criteria:
inclusion criteria: * patients over 18 and affiliated to the french social security system * patients on curative heparin (low molecular weight heparin or non-fractionated heparin) for whom anti-xa activity is prescribed or planned by the clinician * samples taken between working hours * no opposition to study participation exclusion criteria: * patients unable to consent * anti-xa activity not prescribed * patients on another anticoagulant treatment or not anticoagulated about it * samples taken during non-working hours * pregnant or breast-feeding women * insufficient language level for understanding the information note

Keywords: anti xa activity heparin treatment