Kornimate/medical-research-clean huggingface dataset:
alcohol & exercise study

Conditions: Alcohol-Related Disorders

Summary: the goal of this clinical trial is to learn if exercise can reduce alcohol craving in heavy social alcohol drinkers. the main questions this project aims to answer are 1) compared to a distraction activity (i.e., coloring), will mild-to-moderate intensity exercise (i.e., walking on a treadmill) reduce alcohol craving; 2) compared to a distraction, will mild-to-moderate intensity exercise reduce the amount of consumption of an alcohol-placebo beverage.

upon arriving to the study, participants will complete baseline measures assessing for the inclusion and exclusion criteria, as well as baseline alcohol craving and subjective response measures. participants will then be randomly assigned into the active treatment (exercise) or distraction (coloring) condition. after randomization, participants will consume a low-dose alcohol beverage (bac=0.03g/dl; equivalent to approximately 1 standard alcohol beverage) within five minutes to induce active alcohol craving. 15 minutes post-beverage consumption, participants will complete the alcohol craving and subjective response measures. at 20 minutes post-beverage consumption, participants will begin their randomly assigned 20-minute activity (exercise or coloring). at approximately 12 minutes into the activity (32 minutes post beverage consumption) and immediately after the activity (44 minutes post beverage consumption), the participants will complete the alcohol craving and subjective response measures. participants will then be given a tray of three 8oz. cups of water and 3 8oz. cups of an alcohol-placebo beverage and will be allowed to drink as much or as little of the beverages as they would like.

Eligibility criteria:
inclusion criteria: * heavy social alcohol drinkers (i.e., alcohol drinkers who consume 10-40 standard alcohol beverages per week and participate in 1-5 binge drinking episodes \[consume 4+/5+ drinks in a sitting for women/men, respectively\]) per week. exclusion criteria: * meets dsm-5 diagnostic criteria for a current moderate or severe alcohol use disorder * meets dsm-5 diagnostic criteria for a current moderate or severe cannabis use disorder * endorses daily smoking of tobacco * endorses having a current dsm-5 psychiatric disorder * endorses having any medical conditions that may interfere with the exercise condition (e.g., knee-replacement, sprained ankle, etc.) * has a current level of physical activity that exceeds 20 minutes of moderate-to-vigorous physical activity per day * endorses illicit substance use (i.e., use of illicit substances x\&gt;2 times in the past year) * has self-reported allergies to pineapple juice, cranberry juice, orange juice, \&/or tonic water * individuals not proficient in reading, writing, or speaking in english * women who are trying to conceive or who are pregnant * women who are currently breastfeeding

Keywords: alcohol exercise heavy drinkers alcohol craving
transoral incisionless fundoplication (tif) versus sham for treatment of gastroesophageal reflux disease (gerd)

Conditions: Gastroesophageal Reflux Disease; Hiatal Hernia

Summary: the study objective is to evaluate the relative merits, safety and effectiveness of transoral incisionless fundoplication (tif) in proton pump inhibitor (ppi) dependent gerd patients compared with sham procedure.

primary effectiveness endpoint: the proportion of patients in clinical remission after 6 months (without being classified as treatment failure). secondary effectiveness: ppi consumption, esophageal acid exposure, reduction in qolrad and gsrs scores and healing of reflux esophagitis.

Eligibility criteria:
inclusion criteria: * age 18-80 years * on daily ppis for \> 6 months * documented ppi dependency * persistent gerd symptoms without ppi therapy during the titration phase of the study * evidence of two or more of the following while off ppi therapy (\> 10 days): * erosive esophagitis (los angeles grade a-c) * abnormal ambulatory ph study * moderate to severe gerd symptoms * normal or near normal esophageal motility (by manometry) * patient willing to cooperate with post-operative dietary recommendations and assessment tests * signed informed consent exclusion criteria: * bmi \> 35 * hiatal hernia \> 3 cm * esophagitis la grade d * esophageal ulcer * esophageal stricture * barretts esophagus (prague: c\>1, m\>2) * esophageal motility disorder * severe gastric paralysis * pregnancy or plans for pregnancy in the next 12 months * immunosuppression * asa \> 2 * portal hypertension and/or varices * history of previous resective gastric or esophageal surgery, cervical spine fusion, zenker's diverticulum, esophageal epiphrenic diverticulum, achalasia, scleroderma or dermatomyositis, eosinophilic esophagitis, or cirrhosis * active gastro-duodenal ulcer disease * gastric outlet obstruction or stenosis * severe gastroparesis or delayed gastric emptying confirmed by solid-phase gastric emptying study if patient complains of postprandial satiety during assessment * coagulation disorders

Keywords: gerd esophagitis fundoplication anti-reflux surgery ppi dependent
a proof-of-concept study to reduce treatment burden in haemophilia participants receiving factor viii and factor ix infusions

Conditions: Hemophilia

Summary: the main aim is to describe how the treatment burden and challenges of participants, relatives, and doctors during regular factor viii and factor ix infusions to treat hemophilia evolve using a virtual-reality (vr) based solution. the study also aims to find out how well the vr based solution is tolerated and how satisfied the participants, relatives, and doctors are with it. the vr-based solution includes a mobile phone app and a 3d mask. participants will use the vr-based solution while receiving prophylactic factor viii and factor ix infusions for 4 weeks at home. participants will visit the clinic for the last infusion; at this time data will be collected from participants, relatives, and doctors


Eligibility criteria:
inclusion criteria: 1. male participant over the age of 6 years, with diagnosed congenital hemophilia a or b, whatever the severity is 2. participant under long-term prophylaxis with intravenous factor viii or factor ix infusions 3. participant (or the legal guardians if participant age \<18 years) able and willing to give written informed consent and to comply with the requirements of the study protocol 4. participant affiliated to the national social security or beneficiary to such insurance exclusion criteria: 1. participant with known or suspected hypersensitivity to virtual-reality based tools 2. participant with central venous line for the administration of factor viii or factor ix 3. participant (and the legal guardians if participant age \<18 years) with history of unreliability or non-cooperation (including for completion of self-reported questionnaires) 4. participant (and the legal guardians if participant age \<18 years) with insufficient comprehension of french language 5. participant taking part in another clinical trial 6. participant deprived of his liberty by judicial or administrative order nb: participants with haemophilia a having participated in the test phase of the study could be included in the clinical study itself after a period of 4 months minimum with no use of the virtual-reality based solution.

Keywords: drug therapy
a phase 1 dose-escalation trial of sgn-75 in cd70-positive non-hodgkin lymphoma or renal cell carcinoma

Conditions: Carcinoma, Renal Cell; Lymphoma, Non-Hodgkin

Summary: this is a phase 1, open-label, dose-escalation clinical trial to evaluate the safety of sgn-75 in patients with cd70-positive relapsed or refractory non-hodgkin lymphoma or metastatic renal cell carcinoma.


Eligibility criteria:
inclusion criteria: * pathologically-confirmed diagnosis of nhl or rcc * relapsed, refractory, or progressive disease following at least 1 prior systemic therapy * confirmed cd70 expression * measurable disease, defined as at least 1 lesion \>1.5 cm in the greatest transverse diameter for patients with nhl, and at least 1 non-resectable tumor lesion \> or equal to 10 mm in diameter for patients with rcc exclusion criteria: * previously received an allogeneic transplant * history of another primary malignancy that has not been in remission for at least 3 years * prior anti-cd70-directed therapy

Keywords: antibodies, monoclonal antibody-drug conjugate antigens, cd70 lymphoma, non-hodgkin carcinoma, renal cell immunotherapy drug therapy monomethylauristatin f
monitoring blood pressure at home

Conditions: Hypertension

Summary: the overall goal of this project is to determine if measuring blood pressure at home and staying in contact with a team of pharmacists and physicians to manage your blood pressure is feasible. the study will enroll 24 participants at uab who are seen at the emergency department post-discharge clinic. half of the participants (12 patients) will be asked to measure their blood pressure at home, and half of the participants (12 patients) will continue to receive usual care. participants who measure their blood pressure at home will also meet with a pharmacist weekly over the phone to discuss blood pressure readings and have blood pressure medications prescribed if needed. this program will last 3 months.

for all participants: 1. participants will receive information on the importance of measuring blood pressure and ways to improve blood pressure. 2. participants will complete questionnaires describing current socioeconomic position, medical history and healthcare needs. 3. participants will come in for one research clinic visit to get blood pressure measured 3 months after enrollment in this study. for participants asked to measure blood pressure at home: 1. measure blood pressure twice a day at home, following the instructions provided. the study will provide participants with the device and send text message reminders each week day. participants will return the device at study visit 3 months from now. 2. following the instructions provided, participants will talk to a pharmacist over the phone weekly to discuss blood pressure and medications. all medication changes will be discussed with a collaborating physician. 3. participants will complete questionnaires on satisfaction with the program.

Eligibility criteria:
inclusion criteria: * patients seen at the emergency department post-discharge clinic * \>=18 years * blood pressure \>=130/80 mmhg and \<=160/100 mmhg * english speakers * have a smartphone exclusion criteria: * patients with blood pressure \>=160 mmhg

Keywords: hypertension blood pressure
epilepsy self-management for spanish speakers: hobscotch - espanol

Conditions: Epilepsy; Cognitive Dysfunction; Memory Disorders

Summary: the goal of this pilot study is to assess the feasibility of translating and delivering the existing home-based epilepsy self-management intervention, hobscotch, for people with epilepsy whose primary language is spanish. the main questions it aims to answer are: 1. can the current hobscotch program be successfully translated for spanish speaking people with epilepsy? 2. will people with epilepsy who speak spanish experience improved quality of life similar to that found in people with epilepsy who received the hobscotch program in english? participants will be asked to: * attend nine, one-hour virtual (online and/or by telephone) hobscotch-spanish sessions with a one-on-one certified bilingual hobscotch coach * complete a brief clinical questionnaire about their diagnosis of epilepsy * complete two questionnaires before and after the hobscotch sessions about their quality of life and about memory and thinking processes * keep a short daily diary about their seizures, symptoms and use of the self-management strategies taught in the hobscotch program * complete a brief satisfaction survey and a 3 question survey about shared decision making after the entire hobscotch program


Eligibility criteria:
inclusion criteria: * adult (18 + years) * self-reported epilepsy with controlled or uncontrolled seizures * spanish as primary language * literate in spanish (per bilingual cognitive coach) * access to the internet and/or a telephone exclusion criteria: * self-report of a dementing illness, a dementing illness appearing in their medical record if available or in the judgment of the principal investigator or bilingual coach * severe mental disability or estimated iq less than 70 per clinical judgement of the principal investigator or bilingual coach * significant visual impairment precluding reading or writing * no reliable telephone or internet access * no self-reported diagnosis of epilepsy

Keywords: epilepsy memory cognitive training self management
radiotherapy for malignant astrocytomas in the elderly

Conditions: Primary Brain Tumor; Anaplastic Astrocytoma; Glioblastoma Multiforme

Summary: a randomized trial comparing radiotherapy with supportive care in patients aged 70 years or older with newly diagnosed, histologically confirmed anaplastic astrocytoma or glioblastoma, and a karnofsky performance status \> 70.


Eligibility criteria:
inclusion criteria: * glioblastoma and anaplastic astrocytoma, supratentorial, histologically confirmed * brain ct scan or mri within 28 days before surgery * age: 70 years or older * karnofsky performance status, 70 or more. * life expectancy over 12 weeks * informed consent exclusion criteria: * brain radiotherapy * chemotherapy * severe systemic disease

Keywords: malignant gliomas
a comparison between 2 methods of local anesthetic administration for maintaining labor analgesia after dural puncture epidural

Conditions: Labor Pain; Epidural; Pain, Labor

Summary: intermittent epidural bolus technique opens a new era of interest for maintaining labor anlagesia. the study examines programmed intermittent epidural bolus technique on a scheduled basis to provider-administered bolus anlgesia on patient request, after a dural puncture epidural technique.

after dural puncture, an epidural catheter will be placed on nulliparous women between 38 and 40 weeks of gestation presenting for labor . all will receive an test dose of 3ml lidocaine 2%, for properly checking the catheter placement and then an initial dose of 10ml ropivacaine 0,2% with 2 mcg/ml fentanyl. after that, women will be randomly assigned on two groups. both groups will be receiving the same dose of analgesia (10ml ropivacaine 0,2% plus 1,5 mcg/ml fentanyl. however, one group will be receiving them on scheduled time intervals as programmed intermittent boluses every 60minutes and the other only on patient request for pain relief. pain scores, satisfaction, time for adequate analgesia, bromage scores,apgar scores, fetal arterial blood gases, time for delivery and type of delivery will be studied

Eligibility criteria:
inclusion criteria: -nulliparous women * 38th week of gestation exclusion criteria: * patient refusal to have an epidural * patient refusal to participate * contraindication for epidural * asa\>3 * neurologic deficit/impairment * allergy on local anesthetic chronic pain syndromes

Keywords: dural puncture programmed intermittent bolus labor analgesia
dietary acid load and oral health quality in adolescents

Conditions: Adolescent

Summary: this study investigates the link between dietary acid load and oral health-related quality of life in 374 high school students (226 females, 148 males). participants completed a demographic questionnaire, the ohip-14 scale, and provided 24-hour dietary recalls. dietary acid load was assessed using pral and neap calculations. data analysis was performed with spss 24 to explore the impact of diet composition on adolescents' oral health.

introduction: oral health plays a crucial role in the psychological and physical development of children and adolescents. the composition of the diet consumed significantly affects oral health. objective: this study aimed to examine the relationship between dietary acid load and oral health-related quality of life in adolescents. method: a total of 374 high school students (226 females, 148 males) participated in the study. adolescents completed a demographic questionnaire and the oral health impact profile-14 (ohip-14) scale, and 24-hour retrospective food consumption records were collected. dietary acid load was assessed by calculating potential renal acid load (pral) and net endogenous acid production (neap) based on macronutrient and micronutrient intake from food records. data analysis was conducted using the spss 24 software package.

Eligibility criteria:
inclusion criteria: * 14-18 ages exclusion criteria: * those with diagnosed eating disorders * those with diagnosed psychiatric * those with diagnosed cancer

Keywords: dietary acid load oral health quality of life adolescents
different doses of naronapride vs. placebo in gastroparesis

Conditions: Gastroparesis

Summary: this is a double-blind, randomized, multicenter, placebo-controlled, comparative phase ii dose-finding trial. the trial will be conducted with four treatment groups in the form of a parallel group comparison and will serve to compare oral treatment with daily doses of 10, 20, or 40 mg naronapride vs. placebo for the treatment of patients with gastroparesis.


Eligibility criteria:
inclusion criteria: * men and women between ≥18 and ≤75 years of age, * body mass index (bmi) ≥16 and \<35 kg/m2 , * history of idiopathic or diabetic gastroparesis cardinal symptoms (e.g., nausea, vomiting, early satiety, postprandial fullness, bloating or upper abdominal pain) for ≥3 months, * evidence of delayed gastric emptying by 13c-spirulina gastric emptying breath test (gebt) for solids with gastric emptying t1/2 ≥ 85.33 minutes (≥ 90th percentile of normative data) during the screening phase, * average weekly total symptom score of the anms gcsi-dd ≥2.0 based on the daily symptom scores recorded for at least 5 of 7 consecutive days in the week prior to baseline, * participants with a type i or type ii diabetes mellitus diagnosis must have a controlled diabetes mellitus defined as hba1c ≤11% under stable antidiabetic medication, * exclusion of any mechanical and/or anatomical obstructions, stenosis, structural diseases, or gastric ulcers by upper gastrointestinal endoscopy during screening phase (previous endoscopic results within 12 months are acceptable, if no relevant changes in patient's disease status occurred since that time), * no evidence of intestinal stenosis as determined by an imaging technique (i.e., either abdominal sonography, magnetic resonance imaging \[mri\] or imaging by computed tomography \[ct\] during screening phase (previous mri/ct imaging or sonography results within 12 months are acceptable, if no relevant changes occurred in patient's disease status since that time), exclusion criteria: * history of major gastrointestinal surgery such as gastric bypass, anti-reflux surgery, gastric per oral endoscopic myotomy (g-poem), gastrointestinal malignancy, colectomy, * intrapyloric botulinum toxin injection within 12 months, * gastric stimulator implant, * known secondary causes of gastroparesis including but not limited to parkinson's disease, cancer, or connective tissue diseases,

Keywords: stomach diabetes mellitus
the rapid - pe study: rescue advanced protocol for the treatment of pulmonary embolism

Conditions: Pulmonary Embolism

Summary: to demonstrate the efficacy and safety of the 8f bashir™ .035 endovascular catheter and the 8f bashir™ s-b .035 endovascular catheter for the administration of pharmaco-mechanical catheter directed therapy using pulse sprays of r-tpa into the pulmonary arteries for the treatment of intermediate risk pulmonary embolism (pe).

the bashir™ .035 endovascular catheter (bec) and the bec short basket .035 (s-b) are devices intended for the localized infusion of therapeutic agents into the pulmonary artery and peripheral vasculature. the distal infusion segment of the device contains an expandable radial array of conduits with a total of 48 laser drilled orifices used for the delivery of the therapeutic agents at multiple cross-sectional points of the target vessel location. the infusion segment can be expanded and collapsed by the actuator (slider) located on the handle at the proximal end of the device. the infusion line connector is also located on the handle. the difference between the bec .035 and the bec s-b.035 is solely in the length of the basket. in its unexpanded state, the basket of the bec .035 is 12.5cm long and the bec s-b .035 basket is 10cm long. the choice of device used will be at the physician's discretion based on the patient's anatomy.

Eligibility criteria:
inclusion criteria 1. willing and able to provide informed consent; 2. pe symptom duration ≤ 15 days; 3. filling defect in at least one major lobar pulmonary artery as determined by cta; 4. patient is diagnosed with intermediate risk pe; 5. rv/lv diameter ratio ≥ 0.9 by cta, as determined by investigative site; 6. willing and able to comply with all study procedures and 7-day and 30-day telephone follow-up visit. exclusion criteria: 1. previous history of stroke with residual hemiplegia; 2. major surgery ≤ 10 days prior to inclusion in the study; 3. platelet count \< 100,000/μl; 4. pulmonary thrombectomy within the previous 4 days; 5. uncontrolled hypertension defined as systolic blood pressure \>180 mm hg and/or diastolic blood pressure \>110 mm hg at the time of the procedure; 6. administration of thrombolytic agents within the previous 4 days; 7. absolute contraindication to anticoagulation; 8. clinician deems high-risk for catastrophic bleeding; 9. pregnancy; 10. any vasopressor or inotropic support; 11. cardiac arrest (including pulseless electrical activity (pea) and asystole) requiring active cardiopulmonary resuscitation (cpr) during this hospitalization at treating institution and/or referring institution; 12. planning to administer r-tpa by infusion after the r-tpa is administered by pulse sprays; 13. currently participating in another study; 14. in the opinion of the investigator, the subject is not a suitable candidate for the study.

Keywords: pulmonary embolism catheter directed therapy
optimization of music compression

Conditions: Hearing Loss

Summary: hearing impaired persons suffer from inferior music perception with and without hearing aids. hearing aids, however, are primarily designed to improve speech intelligibility not music enjoyment. this study investigates the potential benefit of signal processing strategies that are optimized for music. the purpose of this study is to improve music compression for hearing impaired people.


Eligibility criteria:
inclusion criteria: * female and male adults between 18 and 99 years * german-speaking * symmetric, mild to severe, ski-slope hearing loss * binaural hearing aid user without frequency lowering * informed consent as documented by signature exclusion criteria: * have taken part in a study at phonak within 4 months prior to the first session * people with mental-health problems * people whose audiogram is older than 12 months and it is not possible make a reliable measurement * very limited motor activity or mobility
effect of regulated oxygen-enriched negative pressure therapy (ro-npt) on soft tissue wound repair

Conditions: Wounds and Injuries

Summary: the investigators believe that regulated oxygen-enriched negative pressure therapy (ro-npt) will be beneficial in the reduction or elimination of anaerobic infection in hard-to-heal soft tissue wounds.


Eligibility criteria:
inclusion criteria: * patients with hard-to-heal wounds exclusion criteria: * everyone else