intensive intervention for toddlers with autism (early steps)

Conditions: Autism; Autism Spectrum Disorder

Summary: goals of the current project: (1) does the early start denver model experimental intervention for toddlers with autism reduce disability associated with autism significantly more than standard community interventions?; and (2) what environmental, child, and biological characteristics mediate and moderate intervention response and outcomes at age 4?

thanks to the development of better diagnostic tools and a greater level of professional education, autism is being identified in two year olds and in even younger children, with such early diagnosis justified by the rationale that the earlier intervention begins, the better the outcomes may be. however, there are no published outcome data on intervention models or effectiveness for children who begin intervention by or before 24 months. furthermore, some teaching procedures considered appropriate for older children, (e.g., 40 hours per week of adult-directed intervention, much repetitive practice while sitting at a table (lovaas, 2002), 1987) are considered developmentally inappropriate for toddlers (sandall, mclean, \& smith, 2000). dawson and rogers have implemented a feasibility study of a intervention designed for toddlers with autism using a randomized controlled design. the approach involves a relationship-based frame to accomplish developmentally based objectives using naturalistic application of applied behavior analytic principles. the approach fuses the denver model (rogers, hall, osaki, reaven, \& herbison, 2000) and pivotal response training (koegel, koegel, \& carter, 1999), and is delivered 1:1 for 25 or more hours per week to 24 toddlers with autism for a two year period. the contrast group receives standard community based intervention. preliminary results demonstrate large and significant group effects after only 12 months and considerable variability of intervention outcomes in both groups. all families will be referred to the appropriate community service programs, if they have not been referred previously.

Eligibility criteria:
inclusion criteria: (1) 12-24 months of age at the time of telephone screening and living within 60 minutes of the university clinic; (2) ambulatory; (3) unimpaired hand use; (4) parent agreement to have a caregiver present during all home sessions; (5) attendance at all intake sessions; (6) permission to videotape evaluations and esdm treatment; (7) english as one primary language of the parent; (8) unimpaired hearing and vision; (9) developmental quotient of 35 or higher on the mullen scales of early learning (msel); and (10) meets all of these asd diagnostic criteria: (a) autism diagnostic observation scale for toddlers (ados-t) cutoff score of 12 if child produces no words or 10 if child produces some words; (b) agreement by two experienced psychologists that asd is present; and that child meets dsm-iv criteria for autistic disorder or pervasive developmental disorder not otherwise specified (pddnos). 5,7,8 exclusion criteria: (1) serious parental substance abuse; (2) parental self-report of bipolar disorder or psychosis; (3) known genetic syndromes; (4) serious medical conditions (e.g., encephalitis, concussion, seizure disorder); (5) significant sensory impairment; (6) birth weight \<1600 grams and/or gestational age \< 34 weeks; (7) history of intraventricular hemorrhage; (8) known exposure to neurotoxins (including alcohol, drugs); (9) non-english-speaking parents; and for the esdm-assigned group only, (10) current enrollment in an intensive, 1:1 delivered behavioral intervention of more than 10 hours per week. there was no other restrictions on additional community-based treatment.

Keywords: autism autism spectrum disorder intensive intervention for toddlers with autism pdd nos early steps study early start denver model early intervention for infants and toddlers with autism toddler treatment sally rogers university of california, davis university of michigan mind institute