Kornimate/medical-research-clean huggingface dataset:
ai-driven cta reconstruction for intracranial lvo

Conditions: Acute Ischemic Stroke; Artificial Intelligence (AI); Endovascular Thrombectomy; CT Angiography

Summary: acute ischemic stroke (ais) caused by intracranial large vessel occlusion (lvo) in the anterior circulation significantly contributes to stroke-related disability and mortality. recent randomized controlled trials have demonstrated substantial benefits of endovascular thrombectomy (evt) when patients are appropriately triaged beforehand. however, accurately orienting the 'missed segment' during evt remains challenging. guide-wires often fail to navigate through the occlusion or are mistakenly directed into the small tranches or even cause vessel rupture. to address this clinical need, the investigators developed an artificial intelligence (ai) algorithm to automate the reconstruction of ct angiography (cta), focusing on the occluded lvo segment. to evaluate the clinical utility of this ai algorithm, the investigators propose a prospective, stepped-wedge cluster-randomized study to determine whether integrating our ai algorithm into ais care flow can reduce the time for first pass of the thrombus by improving the visualization of the occluded segment on cta. physicians will assess patient eligibility for thrombectomy, and all selected patients will receive standard care according to current guidelines. this approach is expected to enhance patient treatment outcomes for endovascular thrombectomy by leveraging readily available data.


Eligibility criteria:
inclusion criteria: 1. male or female, 18 years of age or older. 2. patients who present with signs and/or symptoms concerning acute ischemic stroke. 3. patients who undergo noncontrast ct and ct angiography imaging. 4. patients determined to have an intracranial large vessel occlusion (including the internal carotid artery, middle cerebral artery m1 segment, and m2 segment), and eligible for endovascular treatment. exclusion criteria 1) ct imaging with severe motion artifacts.
clinical prediction thyroid cancer with thyroid ultrasonography

Conditions: Thyroid Cancer

Summary: iodine ingestion insufficiency was widespread existence in the 50's in taiwan, induced the hypothyroidism with the popular name "the big neck". after many experts study and evaluation, goiter was gradually disappeared after salt adding iodine in the 60's. but the nodule of the thyroid gland was widespread on the taiwan island. this situation was a particular victim in living in the mountainous area inhabitant. the middle area populaces suffer from the thyroid gland disease really popular than other areas. recently literature reported that the cancer rate of thyroid gland rises gradually. in according to the statistics, thyroid cancer prevalence probably has 10% in the nodular goiter. the major early preliminary diagnosis of the thyroid cancer is thyroid fine-needle aspiration cytology (fnac), but this technique must to have skilled clinical puncture's doctor and to have special training cytological pathology doctor. therefore, if we can have simple fast screening tool and can make up this insufficiency, then we can achieved the fast diagnosis, rapid processing, the promotion diagnosis and treatment quality and promotes the survival percentage. the thyroid ultrasonography (thyroid us) is one universal, fast, cheap, and the simple diagnosis nodular goiter tool. if we can friendly use this tool, we can early diagnosis \& management this disease. this research collect subjects from jan 2002 to dec 2016 under procedure of thyroid us, fnac and thyroidectomy. preliminary design index of thyroid gland tumor score (tts) was to survey and analysis.


Eligibility criteria:
inclusion criteria: * 1. patients with nodular goiter had thyroidectomy from 2002 january to 2016 december in cmuh. * 2. patients had thyroid sonography within one year before thyroidectomy. * 3. all data at least was interpreted by 3 endocrinologists under the blind method. exclusion criteria: * 1. patients with nodular goiter hadn't thyroidectomy. * 2. patients hadn't thyroid sonography. * 3. all data was interpreted by endocrinologists under the blind method, but interpretation results were inconsistent.
the effects of amiloride and spironolactone on renophysiological and cardiovascular variables

Conditions: Essential Hypertension

Summary: the investigators wish to study the effect of retaining potassium. the participants have essential hypertension. the test substances are amiloride, spironolactone and placebo. the participants will ingest tablets for 28 days before being examined. we will perform a 24 hours urine collection, 24-hours bloodpressure measurement, blood and urine samples and we also examine the patient using a sphygmocor.

purpose of the study is to examine the effect of amiloride and spironolactone on 1. renal function (gfr, u-aqp2, u-enacβ, u-camp, u-pge2, ch20, fena, fek), 2. pulsewave velocity, augmentation index central bloodpressure, 3. vasoactive hormones (prc, angii, aldo, avp, anp, bnp and endot), and 4. ambulatory bloodpressure

Eligibility criteria:
inclusion criteria: * hypertension, * bmi 18,5-30, * non-smoker exclusion criteria: * smoking * not using contraceptives * other illnesses * drug or alcohol abuse

Keywords: blood pressure, pwv, hrv, pwv, potassium
the effect of red blood cells storage duration on biochemical changes in pediatric patients

Conditions: Red Blood Cells Transfusion

Summary: the aim of the study is to detect if the storage duration of red blood cells has impact on some biochemical parameters after intra operative transfusion in pediatric trauma patient

* a pretransfusion draw of a few drops of patient venous blood, send for analysis by i-stat portable clinical analyser. samples are processed immediately and provide laboratory quality results in 2 minutes using the chem 8+ i-stat cartridge for measurement of: 1. potassium (k) 2. ionized calcium (ica) 3. glucose (glu) 4. urea nitrogen (bun)/urea 5. hemoglobin (hb) and hematocrit (hct). * concurrently, a few drops of blood will be taken from the unit to be transfused will be analysed by i-stat portable clinical analyser for measurement of previous biochemical parameters. * the details of the unit, such as draw date, volume of transfusion, and date of transfusion, will be recorded. the rbc unit will be delivered to the operative room from the blood bank in an insulated box. * the transfusion is then given as clinically indicated at a rate of 50 to 150 ml/h based on the clinician's orders, the patient's weight, and the patient's clinical situation. * volumes will be transfused to children according to the following top-up transfusion equation: desired hemoglobin (hb) (g/dl) - actual hemoglobin (hb) (g/dl) x weight (kg) x 3. (usually 10-20 ml/kg). * a second patient blood sample will be drawn one hour after the transfusion and will be analyzed by i-stat portable clinical analyser. * patient information will be recorded for age, weight, sex, and primary diagnosis. * demographic and clinical variables will be collected, to include type and quantity of all blood products and fluids received and medications administered. all surgical procedures will be documented.

Eligibility criteria:
inclusion criteria: .asa i-ii physical status patients. * genders eligible for study : both . * age: 2_10 years * all non-crush trauma pediatric patients need intraoperative rbc transfusion. * rbcs transfusion volume within 10-20ml/kg. exclusion criteria: * patients with renal failure (serum creatinine 1.5 mg/dl) * hepatic insufficiency. * furosemide diuresis. * succinylcholine for rapid sequence induction. * electrolytes disorders.

Keywords: rbcs, transfusion, pediatric changes
japanese phase i of gsk1605786

Conditions: Crohn's Disease

Summary: this is an double-blind, single dose, four-period, crossover study in japanese healthy male volunteers to assess the pharmacokinetics and safety/tolerability of single doses of gsk1605786a. approximately 24 subjects will receive three treatments of 250, 500, and 1000mg gsk1605786 under fasted conditions or 500mg after food intake plus placebo in a dose ascending crossover design. serial pharmacokinetic samples will be collected following each dose and safety assessments will be performed. the pharmacokinetics and dose proportionality of gsk1605786 after single oral doses of gsk1605786 at the dose levels of 250mg, 500mg and 1000 mg under fasted conditions will be assessed. in addition, a comparison will be made between the pharmacokinetics of gsk1605786 under fed and fasted conditions.


Eligibility criteria:
inclusion criteria: * healthy japanese as * japanese defined as being born in japan, having four ethnic japanese grandparents, holding a japanese passport or identity -male between 20 and 55 years of age inclusive, at the time of signing the informed consent. * body weight =\>50kg and bmi within the range 18.5 - 25 kg/m2 (inclusive). exclusion criteria: - known coeliac disease or positive serologic testing for anti-ttg antibodies (required to screen for undiagnosed celiac disease)
efficacy of using a closing pack to reduce postpartum sepsis

Conditions: Prevention of Postpartum Sepsis

Summary: randomised trial comparing the efficacy and feasibility of using a sterile closing pack to reduce postpartum sepsis

pregnant patients meeting the inclusion criteria undergoing elective or emergency caesarean section will be eligible for recruitment. patients will be randomised into two arms. in the control arm sheath and skin closure will be performed with the instruments used to perform the caesarean section, as per the current standard of care. in the intervention arm, after suturing the uterine incision and obtaining hemostasis and before commencing closure of the sheath and skin, the surgical team (obstetrician, assistant and scrub sister) will don clean sterile gloves, open clean sterile linen to drape on top of the existing linen and open a pack of clean sterile instruments to close the sheath and skin.

Eligibility criteria:
inclusion criteria: * women 18 years and older willing and able to provide consent exclusion criteria: * women who are not able or willing to provide consent patients with existing maternal infection
healthy aging in people with epilepsy program

Conditions: Epilepsy

Summary: the goal of this clinical trial is to develop and test an educational program about dementia in older adults living with epilepsy. the main questions it aims to answer are: 1. can providing education on healthy aging, chronic disease management, dementia, and modifiable lifestyle dementia risk factors improve dementia knowledge and health literacy among older adults with epilepsy? 2. can aging related education and resources improve quality of life among older adults with epilepsy? participants will: * complete a 12-week group educational program. * complete pre- and post-program evaluation.


Eligibility criteria:
inclusion criteria: * current diagnosis of epilepsy made by a neurologist, epileptologist, or internist/family medicine physician * proficiency in english exclusion criteria: * dementia
the efficacy and safety of cettum for perennial allergic rhinitis

Conditions: Rhinitis, Allergic

Summary: the purpose of this study is verify the efficacy and safety of cettum (electrical moxibustion) for patients with perennial allergic rhinitis.

the investigators target the patients with perennial allergic rhinitis. after treatment in 2 groups (cettum treatment and acupuncture treatment) the investigators will compare the effects of relieving symptoms and improving quality of life. so the investigators will confirm the efficacy of cettum, and further the best treatment method. in addition, the investigators are going to evaluate the safety of abnormal reaction during the treatment.

Eligibility criteria:
inclusion criteria: 1. 19 to 60 years-old 2. presence of nasal symptoms more than 2 consecutive years 3. presence of two or more nasal symptoms (rhinorrhea, nasal congestion, nasal itching, and sneezing) with severity score ≥ 2 (0 = no symptoms, 1 = mild symptom(s), 2 = moderate symptom(s), and 3 = severe symptom(s)) 4. positive reaction to the one or more perennial allergen in skin prick test 5. not having a problem with expression of opinion 6. willingness to participate in this trial and to sign the informed consent agreement exclusion criteria: 1. treatment with nasal/oral corticosteroids within the past month; herbal medication for rhinitis within the past month; nasal cromolyn or tricyclic antidepressants within the past two weeks; nasal/oral decongestants, nasal/oral antihistamines, or antileukotrienes within the past week 2. presence of rhinosinusitis (paranasal sinus x-ray demonstrating mucosal thickening or opacification of the paranasal sinuses) 3. presence of neoplasm, severe systemic inflammation, or other systemic disease that affects rhinitis 4. history of anaphylaxis for allergic tests 5. females who is pregnant or lactating 6. being difficult to maintain treatment (e.g. paralysis, severe physical or psychiatric disorder, dementia, drug intoxication, severe visual or hearing impairment) 7. being afraid of moxibustion treatment or expected adverse effects 8. when the investigators determine that it is inappropriate for participation

Keywords: rhinitis, allergic moxibustion
effects of muscle energy technique and postural correction exercises in lordotic females wearing high heels

Conditions: Lordosis; Low Back Pain

Summary: the key purpose was to determine the effects of muscle energy technique (met) and postural correction exercises on low back pain in females wearing high heels. to determine the effects of muscle energy technique \& postural correction exercises in reducing pain, anterior pelvic tilt angle and increasing lumbar range of motion in subjects with chronic low back pain due to lordotic posture in females wearing high heels.

body segments can be defined as the suitable posture positions. body segments are placed in a way that center of gravity of each segment lies vertically. by this appropriate alignment, instead of excessive muscular activity, stability can be achieved by the body by the use of bone structures and ligament. hence, in this way body structures experience the decreased tension. besides the cosmetic effects of high heels, high heels results in increased risk of fall, fracture of bones particularly bones lower extremity, and also the change in normal kinematics of lower limb especially knee joint, and altered weight bearing on medial and longitudinal arches of foot. high heels change the line of gravity and posture of the body. use of high heels change the posture which is compensated by the changes in different segments of the body like increased planter flexion of ankle as well as the displacements of the trunk and posterior pelvic tilting. the whole body mechanics gets affected in females wearing high heels. the center of gravity get disturbed with the use of high heel shoes. in body alignment, pelvis is known to have key importance. any alteration in neutral position of pelvis leads to the compensatory altered movements in different regions, while, the segment which is considered to be the most effect is lumber spine.

Eligibility criteria:
inclusion criteria: 1. age 18-45 years 2. low back pain of no more than 12 weeks duration in lordotic females wearing high heel shoes. 3. females wearing 4 to 5 inches high heel shoes 6 hour per day. 4. increased lumbosacral angle 5. an initial odi score of 20 % to 60 %. 6. localized pain in lumbar spine with no radiating pain towards buttocks, hips or legs. exclusion criteria: 1. any red flags (tumor, fracture, metabolic diseases, rheumatoid arthritis, osteoporosis, resting blood pressure greater than 140/90 mmhg, prolonged history of steroid use, etc) 2. presented with involvement of nerve compression symptoms like radiating pain, change in normal sensory sensations with significant muscle weakness, or hypo reflexia or hyper reflexia. 3. presented with a diagnosis of lumbar spinal stenosis. 4. presented with a diagnosis of lumbar spinal spondylolisthesis. 5. prior surgery to the lumbar region. 6. patients who are already receiving treatment.

Keywords: lordosis mets postural correction exercise
a new objective titration procedure for the treatment of mandibular advancement device in osahs patients

Conditions: Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)

Summary: the aim of this clinical trial is to apply a new objective titration procedure in obstructive sleep apnea hypopnea syndrome (osahs) patients treated with mandibular advancement device (mad), and to compare this new objective titration procedure with the subjective titration procedure which is commonly used in clinical practice. the remotely intelligent sleep monitoring system (risms) will be used in the new objective titration procedure. the main questions it aims to answer are: 1. the efficacy of mad therapy after each titration procedure. 2. the titration time efficiency and the improvement of subjective symptoms after each titration procedure.

in this study, patients diagnosed with osahs and referred for mad treatment will be recruited. the amount of mandibular protrusion seems to be a key factor in the treatment of mad. patients will experience either of the two titration procedures to obtain the optimal mandibular protrusion. one procedure is a new objective titration procedure which will use the risms for the treatment of mad, which will help the clinician instruct the titration according the objective therapeutic indicator. the other procedure is the subjective titration procedure which is commonly used in clinical practice. finally, the researchers will compare the efficacy of the mad therapy, the titration time efficiency and the improvement of subjective symptoms between the two titration procedures.

Eligibility criteria:
inclusion criteria: * osahs patients with ahi≥15 * 18≤age≤70 years; * subject is capable of giving informed consent * refusal of or noncompliance with cpap (continuous positive airway pressure) or unwilling to undergo upper airway surgery * normal clinical, periodontal and temporomandibular joint examination exclusion criteria: * active periodontal problems including tooth mobility * active temporomandibular joint dysfunction * edentulous patients or insufficient teeth to support mad * patients with severe unstable systemic diseases or suffering from psychiatric disorders * enlarged palatine tonsils (friedman grade iv tonsils)

Keywords: obstructive sleep apnea hypopnea syndrome sleep monitoring contactless sensors mandibular advancement device therapeutic outcomes
microbial and pharmacological assessment of chlorhexidine

Conditions: Oropharynx Abnormality; Pneumonia, Ventilator-Associated; Chlorhexidine; Bacterium; Agent; Infection, Bacterial

Summary: ventilator-associated pneumonia (vap) is the most frequent life-threatening nosocomial infection in the icu. oropharyngeal colonization with bacterial pathogens is the first step toward lung infection. oral hygiene with chlorhexidine mouth wash (cmw) is among the most widespread preventive measure to prevent vap. precise microbial documentation of cmw efficacy on oropharyngeal colonization is lacking. investigators wish to determine cmw antimicrobial efficacy in icu ventilated patients and to measure chlorhexidine residual concentration in patients' saliva at the same time-points after cmw.

ventilator associated pneumonia (vap) is the most frequent life-threatening nosocomial infection in the icu. oropharyngeal colonization with bacterial pathogens is the first step toward lung infection. oral hygiene with chlorhexidine mouth wash (cmw) is among the most widespread preventive measure to prevent vap. although many guidelines and expert opinions recommend oral hygiene with chlorhexidine, optimal conditions of cmw use remain unknown. in addition, precise microbial documentation of cmw efficacy on oropharyngeal colonization is lacking. investigators wish to determine cmw antimicrobial efficacy in icu ventilated patients and to measure chlorhexidine residual concentration in the saliva at the same time-points after cmw. in the participanting unit, cmw is performed every 6 hours with a 0.12% chlorhexidine solution. hence, microbial oropharyngeal sampling will be performed 6h after the last cmw (and just before the next one), to assess oropharyngeal colonization and then 15 minutes, 1 hour, 2 hours, 4 hours, and 6 hours after a new cmw to assess cmw efficacy in terms of bacterial growth. in a subset of patients, 0.5 ml of saliva will be collected with a syringe at the same time points, with an additional t30 time (at 30 minutes) to measure chlorhexidine concentration.

Eligibility criteria:
inclusion criteria: * critically-ill patients admitted to the icu and receiving invasive mechanical ventilation for more than 48 hours non-inclusion criteria: * cervical or mouth surgery in the last 15 days; * history of oropharyngeal neoplasm or of cervical or oropharyngeal radiotherapy, * tracheotomy, * age under 18 exclusion criteria: * patients whose samples retrieved less than 10 to the 3 colony forming unit (cfu)/ml bacteria and those who had two or more missing microbiological samples were secondarily excluded

Keywords: oropharyngeal colonization
progevera 10 mg® versus orgalutran® in ovarian stimulation cycles of oocyte donors

Conditions: Infertility

Summary: evaluation of efficacy and safety of medroxiprogesterone acetate (progevera 10 mg®) versus gnrh antagonist (orgalutran®) in ovarian stimulation cycles of oocyte donors


Eligibility criteria:
inclusion criteria: * oocyte donors included in the oocyte donation program of clinica eugin. * 1st oocyte donation cycle at clínica eugin. exclusion criteria: * polycistic ovarian syndrome (pcos). * estradiol levels on day 2 of menstrual cycle \>70 pg/ml. * hormone treatments up to 3 months before the oocyte donation cycle. * medical contraindication to the treatments used in the study