Kornimate/medical-research-clean huggingface dataset:
long term persistence and effect of a booster dose of the japanese encephalitis vaccine ic51

Conditions: Japanese Encephalitis

Summary: the study investigates the long term persistence the japanese encephalitis vaccine ic51 and the need of a booster dose

this is an open label, non-randomized multi-center phase 3 follow-up study. all volunteers having completed trial ic51-304 (nct00595790) will be enrolled into this trial at 2 sites

Eligibility criteria:
inclusion criteria: * at least 18 years of age * written informed consent obtained prior to study entry * subjects correctly included in and having completed study ic51-304 according to the protocol. exclusion criteria: * use of any other investigational or non-registered drug or vaccine in addition to the study vaccine during the study period * immunodeficiency including post-organ-transplantation or immunosuppressive therapy * pregnancy, lactation or unreliable contraception in female subjects
prediction of transfusion-associated complications

Conditions: Transfusion-dependent Anemia

Summary: currently, about 350000 red blood cell concentrates are produced from blood donations in austria every year. in addition to the main effect of replacing lost blood, red blood cell concentrates also have many undesirable effects - from blood group compatibilities, which are easily avoidable due to care, to storage-related side effects, to mostly intensive care problems as a result of massive transfusions, to system-wide effects such as trali, taco and trim. before being administered to patients, red blood cell concentrates undergo an extensive quality assurance process in which a large number of parameters are collected. prior to use on patients, for example, bedside tests and tests for further incompatibilities with a blood sample from the intended patient are performed. with the implementation of patient blood management (pbm) in recent years, the use of red cell concentrates has become more targeted - the number of transfusions is decreasing in most developed countries. however, it is still possible to suffer transfusion-related adverse events (trae). thus, active research activity to reduce these traes continues to be called for. to date, however, it is not known which patients experience transfusion-related adverse events. despite the broad measures of hemovigilance and pre-transfusion testing, it is still not possible to predict which individual patient will respond to a transfusion with a typical adverse event such as hypotension, hemolysis, renal failure, or trali. it seems understandable that characteristics of the patient as well as characteristics of the administered unit could play a role for this. in particular, it is conceivable that a combination of characteristics of the blood unit and characteristics of the patient could determine a complication in the course of administration. for this reason, it seems attractive to use artificial intelligence and machine learning methods to predict any complications.


Eligibility criteria:
inclusion criteria: * all adult patients that received at a blood transfusion the kepler university hospital in the period between 2016-10-31 to 2020-08-31. exclusion criteria: none.

Keywords: artificial intelligence machine learning transfusion complications
a prospective study of body image, social avoidance and distress and psychological functioning in burn patients

Conditions: Depression; Anxiety; Body Image

Summary: the present study seeks to examine the course of body image, social avoidance and psychosocial aspects of depression and anxiety over time in burn patients. gaining a better understanding of the effects of burn injury on body image in burn patients over time could help us to better understand the psychosocial sequelae of burns and to identify potential interventions which may serve to improve the quality of life in burn patients.

gaining a better understanding of the effects of burn injury on body image in burn patients over time could help us to better understand the psychosocial sequelae of burns and to identify potential interventions which may serve to improve the quality of life in burn patients. the original protocol has been modified to include more assessment times. the original protocol was set up to assess patients after patient discharge from the inpatient burn unit and at 6 and 12-months post discharge. the present protocol has been modified to capture assessments at 2 weeks, 3 months, 6 months, 9 months, 12 months post-burn. patients will be assessed at these time points or until they are discharged from the outpatient burn clinic. in addition, inclusion criteria have been modified to include patients who are anticipated to have a follow-up visit to the burn outpatient clinic at 3 months post-burn. the original protocol required an anticipated follow-up for 12 months post-hospital discharge.

Eligibility criteria:
inclusion criteria: * patients are admitted to the saint elizabeth regional medical center burn unit. * age 19 and older. * patients have the cognitive and physical capacity to answer the questionnaires. * patients are expected to be seen at follow-up clinic visits or if they are still in the hospital within 2 weeks and at 3 months (+ or - 4 weeks)post-burn. exclusion criteria: * patients are unable to return for follow up visits

Keywords: psychological functioning in burn patients
the effect of kinesiology taping on balance in duchenne muscular dystrophy

Conditions: Balance; Duchenne Muscular Dystrophy

Summary: investigators investigated that the effects of kinesilogy taping on balance in patients with duchenne muscular dystrophy

forty-five patients from level 1 and 2 according to the brooke lower extremity functional classification were included in the study. balance was assessed by pediatric berg balance test (pbbt), timed and go test (tugt), and standing on one leg test. kinesiology taping (kt) with facilitation technique was applied on bilateral quadriceps and tibialis anterior muscles and the assessments were repeated 1 hour after application. the comparison between before and after taping was analyzed.

Eligibility criteria:
inclusion criteria: dmd diagnosis being level i and ii according to brooke lower extremity functional classification no cooperation problem no injury or orthopedic/neurologic surgery within the past 6 months no severe contracture at ankle exclusion criteria: children who did not meet the above criteria were not included

Keywords: kinesiology taping balance duchenne muscular dystrophy
association between cell-free nucleic acid in blood, urine and microbiome in stool with pancreatobiliary cancer

Conditions: Pancreatic Cancer; Cholangiocarcinoma; Gallbladder Cancer

Summary: based on the cell free nucleic acid analysis information of blood samples, the results of microbiome and metabolite analysis of stool and urine samples of pancreatic cancer and bile duct cancer patients, the clinical correlations of them with primary cancer are evaluated. and based on these information, biomarkers for diagnosis, treatment, and prognosis of pancreatic and bile duct cancer are explored.


Eligibility criteria:
inclusion criteria: * patients diagnosed with pancreatic cancer through histological or radiologic examination and before treatment begins * patients diagnosed with biliary tract cancer (cholangiocarcinoma, gallbladder cancer) through histological or radiologic examination and before treatment begins * patients aged 18 or older who voluntarily agrees to participate in the study and is willing to understand and comply with the subsequent treatment procedures and sample collection schedule exclusion criteria: * where the subject himself/herself refuses to fill out the consent form or is unable to fill out the consent form * in the case where the sample storage conditions suggested by the reagent manufacturer are not satisfied * only samples that can cause errors when determining results are acquired: * heat treated specimen * incompletely coagulated serum and bacterial samples ③ samples with particulate matter elements (e.g., fibroblasts, red blood cells) remaining in the sample ④ specimens previously frozen and stored with blood clots that have confirmed an increase in non-specific reactivity in which samples appear to have denatured during storage ⑤ sample from deceased patient ⑥ a patient specimen with a malignancy of ohter site ⑦ sample from vulnerable persons such as pregnant women, minors, etc

Keywords: cell-free nucleic acid microbiome biomarker
association between grade(b/c)of stage iii and iv periodontitis and high sensitivity c reactive protein level in serum and oral rinse sample

Conditions: hsCRP

Summary: according to 2017 world workshop of periodontology , the level of high sensitivity c reactive protein has been assumed to increase according to the grade of periodontitis, however, specific evidence regarding this is lacking at present. hence, measuring high sensitivity c reactive protein in serum and oral rinse samples in systemically healthy individuals with periodontitis could be potentially useful in gaining insight on the systemic burden of periodontal disease.

according to 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions , the level of high sensitivity c reactive protein has been assumed to increase according to the grade of periodontitis, however, specific evidence regarding this is lacking at present. moreover, no information is currently available regarding the feasibility of detecting high sensitivity in oral rinse samples, which are relatively easy to collect and store, as compared to more commonly investigated oral fluids like saliva and gingival crevicular fluid previous literature reports that saliva and gingival crevicular fluid levels of high sensitivity c reactive protein correlate with serum high sensitivity c reactive protein levels, therefore, there is a possibility that high sensitivity c reactive protein in oral rinse samples might also be correlated with serum high sensitivity c reactive protein levels. measuring high sensitivity c reactive protein in serum and oral rinse samples in systemically healthy individuals with periodontitis could be potentially useful in providing easily accessible information about the systemic burden of periodontal inflammation as well as regarding detection of subclinical systemic inflammation.

Eligibility criteria:
inclusion criteria: * patients in the age group of (18-50 years) * presence of ≥ 20 natural teeth * ability and willingness to give written informed consent * patients belonging to 3 groups -periodontally healthy, stage iii and stage iv grade b periodontitis, and stage iii and stage iv grade c periodontitis . exclusion criteria: * • patients with chronic inflammatory disease such as nephrotic syndrome, chronic renal failure, significant cardiovascular disease, established type 1 or type 2 diabetes mellitus, or active cancer within the past 5 years * smokers and alcoholics * pregnant females * presence of xerostomia * patients undergoing radiotherapy * having received professional periodontal treatment within the previous 6 months * having received antibiotic medication 3 months prior to study * periapical pathology or other oral inflammatory conditions * cognitive disability (interfering with ability to give sample)

Keywords: periodontits
phase ii study of pallidotomy for parkinson disease

Conditions: Parkinson Disease

Summary: objectives: i. evaluate the safety and efficacy of pallidotomy immediately following 3 preoperative assessments vs. delayed pallidotomy following 6 months of standard medical therapy in patients with parkinson disease.

protocol outline: this is a randomized study. one group of patients undergoes the surgical procedure pallidotomy, a precise lesioning of brain cells in the globus pallidus. the other group receives standard medical care for 6 months followed by a pallidotomy.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- idiopathic parkinson disease hoehn and yahr stage iii or worse during "off" periods responsive to levodopa by history or exam sub-optimal clinical response to maximal medication medication optimized for at least 4 weeks prior to entry no atypical or secondary disease, e.g.: * no history of cerebrovascular accident * no cerebellar involvement * no severe brain atrophy on magnetic resonance imaging no mattis dementia rating scale score less than 116 no dementia meeting diagnostic and statistical manual of mental disorders-iv criteria no hamilton depression rating scale score greater than 10 no hamilton anxiety scale score greater than 14 --patient characteristics-- other: no medical contraindication to surgery, e.g.: * diabetes * cardiopulmonary disease

Keywords: parkinson disease neurologic and psychiatric disorders rare disease
phase 3 study of oto-201 in acute otitis externa

Conditions: Acute Otitis Externa; Swimmer's Ear

Summary: this is a prospective, randomized, double-blind, sham-controlled, multicenter, phase 3 study in which eligible subjects with acute otitis externa (aoe) will be randomized to receive a single administration of either 12 mg oto-201 or sham-control (empty syringe) to the external auditory canal of the affected ear(s).


Eligibility criteria:
inclusion criteria includes, but is not limited to: * subject is a male or female age 6 months or older * subject has a clinical diagnosis of unilateral or bilateral acute otitis externa * subject or subject's caregiver is willing to comply with the protocol and attend all study visits exclusion criteria includes, but is not limited to: * subject has tympanic membrane perforation * subject has eczematoid otitis externa * subject has diabetes mellitus
pain coping strategies in children with cp

Conditions: Cerebral Palsy; Pain

Summary: the aim of the study is to describe pain coping strategies and their evolution in children and adolescent with cerebral palsy.

towards the end of the 20th century, lazarus and folkmann developed the concept that the individual provides "cognitive and behavioral efforts to control, reduce or tolerate the internal or external demands that threaten or exceed his or her resources". these cognitive and behavioral efforts are grouped under the term "coping", which describes a process rather than personality traits or abilities. coping is not about controlling stress but about diminishing, avoiding, tolerating or accepting it. the pain, "unpleasant sensory and emotional experience related to a bodily injury", aims to warn the individual that the integrity of his body is threatened, and is thus a real "stressor". it will lead to the choice of coping strategies, which depends in part on the characteristics of the individual (his beliefs, stress endurance, anxiety propensity) and environmental variables (characteristics of the painful situation, social support and emotional connections, information about the threatening situation). many studies have shown that the strategies used to cope with chronic pain in adults and children play a major role in the adjustment of patients to their pathology, in terms of emotional distress, disability, and quality of life. the different types of strategies have been widely studied in the literature in so-called "typical" children. active strategies classically found in pediatrics are distraction, cognitive self-instruction, and problem solving. these active strategies are said to be positive because they have been proven to help children manage pain more effectively than passive strategies such as catastrophism, helplessness, or seeking social support, which are dysfunctional because they are not focused on the problem and increase the negative consequences associated with pain. this study is about children with cerebral palsy (cp) because the great variability and complexity of the manifestations of the pathology and the therapeutic treatment make it that there is a big risk for the child to experience pain, with a prevalence of pain ranging from 60% to 73%, depending on the evaluation methods. research has done a great deal in recent years to improve the assessment and management of inborn or induced pain in children with disabilities, with many validated recommendations, even though this still appears to be a neglected comorbidity in pc. however, coping strategies of pc children with pain have never been studied. the purpose of this work is to describe these strategies in pc children and adolescents, as well as their evolution.

Eligibility criteria:
inclusion criteria: * confirmed diagnostic of cerebral palsy * gmfcs i, ii, iii, iv * oral language skills with syntactic abilities exclusion criteria: * acute pain episode * severe cognitive impairment
clinical application of patented lyophilized plt in acne scar repairment.

Conditions: Atrophic Acne Scar

Summary: all kinds of skin problems will cause a person's life caused by varying degrees of trouble, especially issues at face. no matter diseases or aging would cause mental pressure and the inconvenience in different ages. scar caused by acne is the most common skin issue amount young people. while acne recovering, due to the destruction of collagen forming fibrous tissue, and scars be left. clinical treatments are facial laser, argon laser and carbon dioxide laser. with the combination of rejuvenation to accelerate growth of collagen when needed. according to journal articles, facial laser combined with platelet-rich plasma is more curative than facial laser treatment alone and can significantly reduce side effects (dermatol surg. 2014 feb;40(2):152-61). platelet has been valued in regeneration medicine due to its various growth factors with repairment, induction and promotion functions. moreover, low risk of allergy for it is an autologous material. platelet had been officially applied in orthopedics and more clinical studies in many other fields. nowadays, preparation of prp is by single-use centrifuge tube, patients have to go through blood collection process every time before therapy due to short shelf life of prp. meanwhile, amount of platelet in prp would be different due to difference of individual, health condition and separation methods. thus, leaving unknown of active principle and uncertainty of treatments. in this trial, a patented technique of lyophilized plt preparation method is applied, collect 250 c.c. of blood specimen by using blood bag, separate platelet in germ-free clean room, then lyophilize platelet to extend shelf life to at least three years after quantifying platelet amount. therefore, treatment could be done after simple dissolution process of plt leads to the convenience of multiple therapy lessons.


Eligibility criteria:
inclusion criteria: - all subjects of acne scars are defined of grades 1, 2, and 3 \[goodman and baron grading scale\] were enrolled in the study. exclusion criteria: * exclusion criteria included treatment with any laser device treatment to the face within 1 month, use of systemic retinoids within 3 months, pregnancy or lactation, a history of hypertrophic scarring or keloids, cancer therapies, uncontrolled diabetes, chronic liver or kidney disease, cardiovascular disease or hematologic disorders. subjects were requested to avoid using any topical products containing alpha-hydroxy acids and salicylic acid on the face during the study period.

Keywords: platelet plt growth factor acne scar repairment laser
pain medication after ambulatory surgery

Conditions: Pain, Postoperative; Medication Adherence; Adverse Drug Event

Summary: in finland, there are no guidelines concerning post-operative pain medication of ambulatory surgery patients. there is a wide variety in drug prescription and medication practices of various doctors and clinics. to treat patients' pain safely, type of surgery, unique patient needs, risks, adverse effects and patient's capacity to follow instructions should be assessed during the few hour visit at the clinic. in many clinics, pain is treated after hospital discharge with strong opioid oxycodone, but the amount and dose of prescribed oxycodone varies. in helsinki universitys hospital, peijas hospital, investigators have over 2000 ambulatory surgery procedures annually. investigators have strict policy in oxycodone use after patient discharge compared to some other finnish ambulatory surgery clinics. the aim of this study is to evaluate, whether the prescribed pain medication is sufficient and whether patients' suffer from adverse effects after discharge from ambulatory surgery (letter interview). the study proceeds in three phases: 1) observation of current medication practice, 2) observation after optimization and standardization of hospitals drug prescription protocol, 3) evaluation of mobile phone app in pain medication follow up.

after informed consent, all patients operated as ambulatory surgery patients during the study period are given a letter interview for pain, pain medication and symptom follow up. they are also given a return envelope (with paid postal fee) to return the interview. based on the results of the first interview phase, our pain medication practice is reconsidered by anesthetists and surgeons to create a standard operating protocol for pain medication. the standard operating protocol is informed to personnel. then, patient interview phase is repeated for another 3 months. then, investigators continue with a pilot study on using a mobile phone app in evaluating patients pain, sufficient pain medication and adverse effects. all patient with informed consent, suitable mobile phone, and willing to use it for reporting pain for hospital personnel are contacted via the mobile app. other patients operated during that study period are interviewed by either letter interview or phone interview. investigators try to estimate whether mobile apps are suitable for pain and medication follow-up.

Eligibility criteria:
inclusion criteria: all plenipotentiary patients, operated as ambulatory surgery patients in our clinic during the study period, with informed consent exclusion criteria: we do not accept patients, who are not plenipotentiary (minor, incompetent, prisoners, conscript in military service) or do not understand finnish or swedish written information

Keywords: pain ambulatory surgery oxycodone adverse effect