a research study comparing cdr132l with placebo on the structure and function of the heart in people with heart failure with reduced/mildly reduced ejection fraction and left ventricular hypertrophy

Conditions: Heart Failure

Summary: this study will look into how cdr132l (a potential new medicine) works on the structure and function of the heart in people living with heart failure. participants will either get cdr132l or placebo (a medicine which has no effect on the body), which treatment the participants get is decided by chance. the study will last for about 60 weeks.


Eligibility criteria:
inclusion criteria: * age 40-84 years (both inclusive) at the time of signing the informed consent. * documented symptomatic heart failure (hf) diagnosed greater than or equal to (≥) 180 days prior to screening with at least weekly need for oral diuretic treatment, and new york heart association class ii-iii at screening. * clinically stable and on optimized doses and unchanged drug classes of guideline-directed hf therapy ≥ 30 days prior to randomization. * left ventricular ejection fraction (lvef) less than (\<) 50 percent (%) as assessed by echocardiography at screening, measured by central laboratory. * left ventricular mass indexed to body surface area (lvmi) greater than (\>) 88 gram per meter square (g/m\^2) for female participants and \>102 g/m\^2 for male participants as assessed by echocardiography at screening, using the truncated ellipsoid method measured by central laboratory. * left atrial volume indexed to body surface area (lavi) ≥ 29 milliliter per meter square (ml/m\^2) as assessed by echocardiography at screening, measured by central laboratory. * body mass index 18.5-40 kilogram per meter square (kg/m\^2) (both inclusive) and body weight less than or equal to (≤) 140 kilogram (kg). body mass index is calculated in the electronic case report form based on height and body weight at the screening visit (visit 1). * n-terminal pro b-type natriuretic peptide (nt-probnp) ≥ 300 picograms per milliliter (pg/ml); nt-probnp ≥600 pg/ml if atrial fibrillation/flutter is present at time of screening, measured by central laboratory. exclusion criteria: * estimated glomerular filtration rate (egfr) less than (\<) 30 milliliter/minute/ 1.73-meter square (ml/min/1.73 m\^2) at time of screening, measured by central laboratory. * participants with an episode of acute kidney failure or acute kidney injury, at the discretion of the investigator, within 90 days prior to randomization. * myocardial infarction, unstable angina pectoris or hf hospitalization within 30 days prior to screening. * participants receiving intravenous hf medications within 30 days prior to randomization. * planned coronary revascularization, pacemaker/cardioverter-defibrillator/cardiac resynchronization therapy (crt) implantation, ablation of cardiac arrythmias or valve repair/replacement at the time of randomization. * stroke or transient ischemic attack within 12 months prior to randomization. * participants with potential disruption of the blood-brain barrier (e.g., multiple sclerosis), in the opinion of the investigator. * known history of severe liver disease and/or alanine aminotransferase or aspartate aminotransferase greater than (\>) 2.5x upper limit of normal at screening, measured by central laboratory. * known genetic cause of increased cardiac mass (including likely pathogenic variants within dilated cardiomyopathy, hypertrophic cardiomyopathy and fabry disease). * participants with suspected or diagnosed cardiac amyloidosis or sarcoidosis.