Kornimate/medical-research-clean huggingface dataset:
national cooperative growth study in ckd

Conditions: Growth Hormone Deficiency

Summary: the purpose of this study is to learn whether growth hormone being administered to children with chronic kidney disease is effective and if it has any side effects.


Eligibility criteria:
inclusion criteria: * must be a patient of the uc davis medical center pediatric clinic with chronic kidney disease exclusion criteria: * greater than 18 years old * not a patient at the uc davis medical center pediatric clinic

Keywords: growth failure and chronic renal insufficiency or end stage renal disease
effect of growth hormone on bone mineral density in young adults with child-hood onset growth hormone deficiency

Conditions: Growth Hormone Disorder; Adult Growth Hormone Deficiency

Summary: this trial is conducted in europe. growth hormone in young adults with growth hormone deficiency in childhood. this trial compares a treated group of patients with an untreated group of patients.


Eligibility criteria:
inclusion criteria: * child-hood onset growth hormone deficiency * subjects received growth hormone replacement therapy during pre-puberty and puberty exclusion criteria: * gh treatment during the month preceding randomisation * treatment within the previous 6 months with medication that may affect bone mineral density * diseases which may affect bone metabolism
analysis of topographic corneal parameters

Conditions: Cornea

Summary: the pentacam hr system (oculus) has been suggested to be one of the most sensitive instruments for corneal examination before corneal refractive surgery

retrospective non randomized study analysis of different corneal paremeters obtained by pentacam for corneal refractive surgery candidates during last 3 years from both sexes between 18 and 45 years k1 - k2 - k max - pachymetry apex - pachymetry thinnest - distance between apex and thinnest - back elevation - topography shape - keratoconus (if present)

Eligibility criteria:
inclusion criteria: * persons from both sexes between 18 and 45 years seeking corneal refractive surgery exclusion criteria: * previous intraocular surgery * previous corneal surgery * corneal opacity
monitoring of cerebral oxygenation using jugular oximetry in comatose patients after cardiac arrest

Conditions: Cerebral Hypoxic Injury; Cardiac Arrest

Summary: the use of protective ventilation (to maintain normoxia and normocapnia), optimise haemodynamics, diagnose/treat seizures, therapeutic hypotermia etc is recommended for icu management of patients who have had cardiac arrest and remain in coma after return of spontaneous circulation according to the latest international guidelines. these actions essentially aim to limit secondary brain injury but despite all therapeutic effort, the cerebral oxygenation may remain inadequate and there is no validated method to avoid such a state in real time.

the use of protective ventilation (to maintain normoxia and normocapnia), optimize hemodynamics, diagnose/treat seizures, therapeutic hypothermia etc is recommended for icu management of patients who have had cardiac arrest and remain in a coma after the return of spontaneous circulation according to the latest international guidelines. these actions essentially aim to limit secondary brain injury but despite all therapeutic effort, the cerebral oxygenation may remain inadequate and there is no validated method to avoid such a state in real time. the objective of this study is to assess the relationship between jugular venous oximetry and neurological outcome of comatose patients after cardiac arrest, evaluated as per the cerebral performance category scale (cpc). further, the aim is to clarify relations between biomarkers protein s100b, neuron-specific enolase (nse) and parameters of jugular oximetry for prognostication. an anticipated total of sixty patients will be enrolled in this non-randomised, single-group, double-blind study. in the course of the study, the authors have decided to stop using bis monitoring for sedation management. reason for this decision was very limited reliability of this technique in unparalyzed patients on icu (muscle artifacts). new aim of sedation was richmond agitation sedation scale (rass) -4 or -5, with avoiding shivering and clinically manifested seizures.

Eligibility criteria:
inclusion criteria: * age 18 or older * successful cardiopulmonary resuscitation * persistent coma defined as: no eye opening to voice and inability to follow commands exclusion criteria: * pre-existing "do not resuscitate" status * severe coexisting systemic disease with a limited life expectancy * pregnancy * patients who will die within 72 h of the initial cardiac arrest

Keywords: cardiac arrest jugular venous oximetry hypoxic brain injury
deep inspiration breath-hold radiotherapy for left-sided breast cancer

Conditions: Breast Cancer; Cardiac Event

Summary: postoperative breast radiotherapy (rt) has been associated with increased risk of heart toxicity. however, there is a lack of knowledge for radiation-induced early cardiovascular injury, especially for hypofractionated rt. this study aims to prospectively detect and predict early clinical or subclinical cardiac events in women undergoing adjuvant rt for breast cancer.

women with left-sided breast cancer undergo hypofractionated rt at either free-breathing or deep inspiration breath-hold. the incidence and potential clinical, dosimetric and biological indicators of early clinical or subclinical cardiac injury are investigate at 2 years.

Eligibility criteria:
inclusion criteria: * primary left-sided breast cancer post surgery * planning for adjuvant breast/chest wall +-rni exclusion criteria: * history of cardiovascular disease * previous chest radiation * bilateral breast cancers
aspet study: an observational study of tarceva (erlotinib) in first line in patients with advanced non-small cell lung cancer harbouring egfr activating mutations

Conditions: Non-Squamous Non-Small Cell Lung Cancer

Summary: this observational study will evaluate the patterns of disease progression in patients with locally advanced or metastatic non-small cell lung cancer (nsclc) harbouring egfr activating mutations receiving tarceva (erlotinib) as first-line treatment. patients will be followed for up to 12 months after progression of disease.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * histologically or cytologically confirmed locally advanced or metastatic (iiib/iv) non-squamous non-small cell lung cancer (nsclc) which is routinely evaluated in clinical practice according to recist criteria * egfr mutation-positive disease according to local laboratory testing * patients on treatment with tarceva monotherapy as first-line treatment according to the physician's usual practice exclusion criteria: * prior systemic therapy for advanced nsclc. the administration of neoadjuvant or adjuvant chemotherapy is allowed as long as it was finalized \>6 months prior to receiving tarceva * participation in another clinical study * patients could have received radiotherapy as long as the irradiated lesion was not the only lesion for evaluating response and a long as the radiotherapy was completed before initiating tarceva treatment
mastering hospital antimicrobial resistance and its spread into the community

Conditions: Bacterial Infection

Summary: detailed activity: * family members and caregivers of carrier residents will be screened for esbl and mrsa. screening will be performed by obtaining nares and perirectal cultures. nares cultures will be obtained by ward staff or research personnel who are experienced in performing this activity: a moisture swab will be applied gently to the distal part of both nares. perirectal cultures, will be taken by swab, who will be applied to the perirectal area, either by staff as mentioned above, or will be given to the participants to perform by himself (with explanation on how to perform it). * the family and caregiver screening form will be filled out; results of screening will be added to the forms. this data will be stored after removal of all family members' identifiers for further analysis. * in order to allow follow up, a list linking between the family members' study number and his identifying details will be kept separately in the rehabilitation center. this list will not be transferred elsewhere.

detailed activity: * family members and caregivers of carrier residents will be screened for esbl and mrsa. screening will be performed by obtaining nares and perirectal cultures. nares cultures will be obtained by ward staff or research personnel who are experienced in performing this activity: a moisture swab will be applied gently to the distal part of both nares. perirectal cultures, will be taken by swab, who will be applied to the perirectal area, either by staff as mentioned above, or will be given to the participants to perform by himself (with explanation on how to perform it). * the family and caregiver screening form will be filled out; results of screening will be added to the forms. this data will be stored after removal of all family members' identifiers for further analysis. * in order to allow follow up, a list linking between the family members' study number and his identifying details will be kept separately in the rehabilitation center. this list will not be transferred elsewhere. * providing results to family members: results of screening will be / will not be reported to the participant (family member) based on local decision in each center.

Eligibility criteria:
inclusion criteria: * family members or caregivers of patient hospitalized in rehabilitation center and who is known carrier of the target resistant population. * participating member older than 18 years, who attend the patient at least once a week, will be eligible for inclusion. exclusion criteria: * age 18 years or less, attending the patient less than once a week.

Keywords: resistant bacteria rehabilitation centers
haic+lenvatinib+tislelizumab vs d-tace+lenvatinib+tislelizumab for unresectable hcc

Conditions: Unresectable Hepatocellular Carcinoma

Summary: drug-eluting bead-transarterial chemoembolization (d-tace) is the most widely used palliative treatment for hepatocellular carcinoma (hcc) patients. while a number of studies demonstrate poor effect of d-tace for patients in advanced unresectable hcc. the investigators previous study also revealed similar results in advanced unresectable hcc patients treated with d-tace. recently, the investigators previous study demonstrated that, compared with d-tace, hepatic arterial infusion chemotherapy (haic) may improve tumor response in advanced unresectable hcc. thus, the investigators carried out this prospective nonrandomized control to demonstrate the superiority of haic-based combination therapy over d-tace-based combination therapy.

hcc is one of the most common malignant tumors with the worst prognosis. at present, except for liver transplantation, surgical resection is the most effective therapy for patients with hcc. however, many patients are found to have advanced cancer as soon as they were diagnosed and lose the opportunity of radical resection and treatments are limited.more and more clinical research failures have hit the investigators' hard, until a clinical study named imbrave150, published in the new england journal of medicine in 2020. it has opened up a new era of combination therapy, breaking the pattern of only a single mode of advanced liver cancer for more than ten years, making the investigators realize that for the treatment of patients with advanced liver cancer, the single treatment effect is often very limited, and combination therapy is the future.the investigators recent research showed that haic combined with lenvatinib and tislelizumab brings good results to patients with advanced hcc.to identify a more effective and safety way for treating potentially resectable hcc patients, this study is designed to compare the safety and efficacy between haic-based combination therapy and d-tace-based combination therapy for those patients in advanced unresectable hcc.

Eligibility criteria:
inclusion criteria: * patients with advanced unresectable hepatocellular carcinoma treated by d- tace, or haic combined with lenvatinib and tislelizumab as initial treatment * age between 18 and 75 years * child-pugh a or b liver function * eastern cooperative oncology group (ecog) performance status 0-1 * adequate hematologic blood counts (white blood cell count \>3ⅹ109/l, absolute neutrophil count \>1.5ⅹ109/l, platelet count \>10ⅹ109/l, hemoglobin concentration \>85 g/l * no extrahepatic metastasis exclusion criteria: * severe underlying cardiac, pulmonary, or renal diseases * history of a second primary malignant tumor * incomplete medical data * loss to follow-up.
impact of percutaneous laparoscopic assisted internal ring ligation during lap orchiopexy

Conditions: Congenital Disorders

Summary: impact of percutaneous internal ring ligation during laparoscopic orchiopexy in decreasing incidence of congenital hernia

cryptorchidism is the most common genitourinary anomaly in male children. its incidence can reach 3% in full term neonates, rising to 30% in premature boys . the treatment of the crypt orchid testicle is justified by the increased risk of infertility and malignancy, as well as an associated inguinal hernia and the risk of trauma to the ectopic testicle against the pubis. furthermore, the psychological stigma of a missing testis for the patient, as well as the parents' anxiety is also factors that justify this type of treatment . about 20% of crypt orchid testicles are non palpable. the treatment of non-descended testicles is mandatory due to the increased risk of infertility, present in up to 40% of the patients, as compared to 6% of control groups, including malignancy, which reaches 20 times that of normal adults . the treatment of the crypt orchid testis before 2 years of age is recommended, treatment is necessary not only for the risk of malignancy, but also for the satisfaction and improvement in the quality of the patient's life and parents´ concern for their children's health. in relation to diagnosis, despite a sensitivity of 70-90% in the diagnosis of inguinal testes, ultrasonography is not useful in intra-abdominal cases . although presenting a better quality, both computed tomography and nuclear magnetic resonance lack sufficient sensitivity and specificity to be considered as gold standard diagnostic tools . more recently, the magnetic angioresonance was introduced with sensibility of 96% and specificity of 100%, but it is still a new method, with high costs, also requiring general anesthesia in children . in relation to the treatment, the use of gonadotrophin for un descended testes presents a success rate of definitive descent to the scrotum of 21 to 56%, with better results in bilateral cases . surgical treatment via an inguinal incision is the main treatment option for palpable testicles, but can also be employed for the evaluation and treatment of non-palpable testis. in this situation, however, surgical exploration can often require large incisions and extensive dissections, especially in bilateral cases. this can be avoided using laparoscopic evaluation, with a sensitivity and specificity reaching more than 90%

Eligibility criteria:
* inclusion criteria 1. age above six months 2. sex must be male 3. surgical approach is closure of internal ring via percutaneous technique after delivery of undescended testis * exclusion criteria 1. age less than 3 months 2. patients with palpable undescended testis 3. any associated major congenital anomalies like cardiac anomalies
neuraxial versus systemic analgesia for latent phase labor effect on rate of operative delivery

Conditions: Labor Pain; Pregnancy

Summary: the purpose of this study in nulliparous women undergoing induction of labor is to determine whether initiation of neuraxial analgesia compared to systemic opioid analgesia early in labor (\< 4 cm cervical dilation)affects the cesarean delivery rate.

women in early labor frequently request pain medication. obstetricians may prescribe narcotics (administered as an intravenous (iv) or intramuscular (im) injection). however, iv or im narcotics provide incomplete pain relief and have maternal and fetal/neonatal side effects, e.g., maternal drowsiness, respiratory depression, nausea, vomiting, and neonatal respiratory depression. other obstetricians allow their patients to request early neuraxial (spinal or epidural) analgesia. the results of several studies comparing patients who received epidural versus iv/im narcotic labor analgesia (not specifically in early labor)suggest that initiation of early neuraxial analgesia may be associated with higher cesarean delivery rates. it has been hypothesized that epidural/spinal local anesthetics may induce pelvic musculature relaxation leading to failure of fetal descent and rotation. however, early pain may be a marker for other factors that increase the risk of cesarean delivery, e.g., large or malpositioned baby, or dysfunctional labor. whether or not early neuraxial analgesia (particularly if narcotic based, which would not cause pelvic muscle paralysis) compared to iv/im narcotics, adversely affects the outcome of labor has not been studied in a randomized, prospective fashion. the purpose of this study is to compare cesarean and forcep delivery rates, and quality of pain relief, in first-time mothers undergoing induction of labor who receive neuraxial versus iv/im analgesia for early labor (cervical dilation \< 4 cm).

Eligibility criteria:
inclusion criteria: * induction of labor * nulliparity * \>36 weeks gestation * singleton * vertex position * cervical dilation \< 4 cm at first request for analgesia * desires neuraxial analgesia exclusion criteria: * spontaneously laboring * multiparity * nonvertex presentation * at or \>4cm at analgesia request * chronic opioid therapy * acute opioid therapy within 4 hours of analgesia request * allergy to study drugs (hydromorphone, fentanyl, bupivacaine, lidocaine)

Keywords: labor pain cesarean section epidural analgesia opioid analgesics local anesthetics labor induced
tai chi quan improving biochemistry and quality of life in type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: in this study, the hypothesis that the 12-week tai chi quan training would have better control of blood sugar, biochemistry profile, and also better quality of life and activity of autonomic nerve system (ans). the subjects were randomize assigned to either tai chi group or control group. the outcome measures before and after 12-week intervention include basic demographic characteristics, hba1c, fasting blood glucose(fbg), triglycerides (tg), high and low density lipoprotein (hdl, ldl), creatinine(cr), egfr, gpt, acr, quality of life, and activity of automatic nerve system.

in this study, the hypothesis that the 12-week tai chi quan training would have better control of blood sugar, biochemistry index, and also better quality of life and activity of automatic nerve system. in the study, type 2 diabetes mellitus(t2dm) patients will be recruited as subjects. the subjects were randomized to either tai chi group or control group. tai chi group would take tai chi quan training for 1hr, twice a week for 12 weeks. there were 10-minute warm-up, 40-minute tai chi lesson, and 10-minute cool-down exercise in the training. in this study, the 1st section of yang style 108 form is chosen for the experiment group. both group were given diabetic patients care education and the exercise recording book for encouraging the daily exercise habits. the outcome measures before and after 12-week intervention include basic demographic characteristics, hba1c, fasting blood glucose, triglycerides, high and low density lipid, creatinine, egfr, gpt, acr, quality of life, and activity of automatic nerve system.

Eligibility criteria:
inclusion criteria: * 40\~80 years old * diagnosed type 2 diabetes mellitus, and without changing dietary pattern and medical treatment for blood glucose or blood lipid. * consciousness clear and is voluntary to attend the project and with the agreement. * the functional movement ability is independent exclusion criteria: * pregnant or plan to be pregnant in six months, and breast feeding. * severe complication in six months such as myocardial infarction, stroke, severe traumatic injury, major surgery. other diseases evaluated by the doctor that are not suitable for the project. * evaluated that the compliance for the intervention is not appropriate. * the blood glucose \> 300mg/dl and unable to do vigorous exercise.

Keywords: tai chi quan hba1c quality of life
the effect of mdz on movement during uia clipping

Conditions: Intraoperative Movement

Summary: this study is a randomized, controlled, double-blinded, and parallel design study. a total 64 patients will be randomized to receive midazolam or normal saline during unruptured intracranial aneurysm clipping surgery.


Eligibility criteria:
inclusion criteria: * patients who undergo elective unruptured intracranial aneurysm clipping surgery * american society of anesthesiologists grade 1,2,3 * age \> 18 year old exclusion criteria: * refuse to participate to the study * body mass index \ 35 kg/m2 * allergic history of benzodiazepine * pregnant
soy protein in early diabetic nephropathy

Conditions: Diabetic Nephropathy; Diabetes Mellitus

Summary: diabetic nephropathy is a frequent cause of end-stage renal disease. reduction of dietary protein has been used to slow down renal disease progression, but patients are often unwilling to make these dietary changes. other research suggests that changing the quality of dietary protein may be as effective as reducing the total amount of ingested protein. this study hopes to show that soy protein, a plant protein relatively high in essential amino acids and with high nutritional value, maye be beneficial to type i diabetic patients with incipient renal disease.


Eligibility criteria:
inclusion criteria: * age 18-40; * diabetic nephropathy; * type i diabetes mellitus.

Keywords: diabetic nephropathy nephropathy diabetes diabetes mellitus type i diabetes soy protein