Kornimate/medical-research-clean huggingface dataset:
effects of a nutraceutic compound on cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: the study is designed to evaluate the effects of choline bitartrate on cognitive impairment in frailty patients. the study will analyze the impact of 4 weeks treatment randomized with a nutraceutical compound in a double-blind randomized placebo controlled trial. the investigators will also assess cognitive frailty.

the patients and controls will be recruited at the hypertension research center of federico ii university hospital. the overall duration of the study will be 4 weeks for each participant. blood pressure, heart rate and cognitive frailty and cognitive impairment will be evaluated for each patient at randomization and after 4 weeks of treatment. patients or controls will be randomized to receive the nutraceutical compound (1 vial of cerebrain per os with 1200 mg of choline bitartrate every 24 hours) or placebo (1 vial per os without active substance every 24 hours). before the start of treatment, patients will undergo full examination of cognitive functions (moca and mmse tests, the parameters will be reported in a password-protected database, using a identification code. the duration of the treatment will be 4 weeks. at the end of the treatment, the patients will repeat the tests and the results will be identified through the use of an alphanumeric code (post-xxxyyy). all cerebrain and placebo, made up of the cerebrain vehicle without the active substance, will be offered free of charge by the farmaceutici damor company.

Eligibility criteria:
inclusion criteria: * mild cognitive impairment exclusion criteria: ictus atrial fibrillation kidney diseases cancer

Keywords: physical frailty cognitive frailty cognitive impairment
dorothy p. and richard p. simmons center for ild research registry

Conditions: Lung Diseases, Interstitial

Summary: the purpose of this study is to place past, current, and future medical record information into the upmc simmons center for interstitial lung disease research registry.

this study gives participant's permission to allow the staff at the dorothy p. and richard p. simmons center for interstitial lung disease to to place past, current, and future medical record information into a upmc simmons center for interstitial lung disease research registry. by placing the medical record information of many patients into a research registry, researchers will be able to conduct research studies directed at increasing our knowledge about interstitial lung disease. it is anticipated that the research registry will assist out investigators by allowing researchers to review and study the medical records of many individuals to answer questions about interstitial lung disease and its treatment. in addition, it will help researchers identify and recruit patients for participation in future research studies.

Eligibility criteria:
inclusion criteria: * adult patients who are seeking treatment at the upmc simmons center for interstitial lung disease * 18 years of age or older exclusion criteria: * n/a

Keywords: "lung[a04.400]"
testing the effectiveness of a computer-based program for depression

Conditions: Major Depressive Disorder

Summary: the purpose of this study is to determine whether completing a computer-based program alters changes how the brain processes emotional information and improves symptoms of depression.


Eligibility criteria:
inclusion criteria: * major depressive disorder exclusion criteria: * substance dependence, psychotic disorder, bipolar disorder, schizophrenia, current psychotherapy, medications other than selective serotonin reuptake inhibitors

Keywords: depression
early detection of lung cancer via bi-plane correlation chest imaging

Conditions: Lung Cancer; Metastatic Cancer in the Lungs

Summary: this project proposes a new method, bi-plane correlation imaging (bci), for improved detection of subtle lung nodules. in bci, two digital radiographs of the chest are acquired within a short time interval from slightly different posterior projections. the image data are incorporated into an enhanced computer-aided diagnosis (cad) algorithm in which nodules present in the thoracic cavity are detected by examining the geometrical correlation of the detected signals in the two views. the data are alos viewed stereoscopically for visual diagnosis. the expected high sensitivity/specificity of the method has the potential to change the current state of practice, perhaps leading to a preventive lung cancer screening program for high-risk populations, similar to the mammography screening program currently in place for breast cancer.


Eligibility criteria:
inclusion criteria: * normal individuals * individuals with ct-confirmed subtle lung nodules. exclusion criteria: * individuals with acute pulmonary abnormalities or those in poor health conditions will be excluded due to the potential impact on the results as well as difficulty of acquiring the images. pregnant women will also be excluded to avoid the exposure of the fetus to radiation.

Keywords: lung cancer nodules radiography ct stereoscopy
natural cycle or stimulated cycle versus hormone replaced cycle for pre-eclampsia rate

Conditions: Pre-Eclampsia

Summary: recent sutdies indicate that the existence of corpus lutein in the ovary is a key point to prevent preeclampsia, and patients undergoing fet with hormone replaced cycle have no corpus lutein and the absence of corpus lutein significantly increases the risk of preeclampsia in these patients. we aim to conduct a single center randomized trial study to compare the preeclampsia rate between the natural cycle and the hormone replaced cycle in patients undergoing fet.


Eligibility criteria:
inclusion criteria: 1. 18 to 42 years old women; 2. normal ovulation; 3. scheduled to undergo frozen-thawed embryo transfer. 4. agreeing with the informed consent. exclusion criteria: 1. those who experienced embryo transfer cycle failure for at least three times; 2. one or both of the ovaries removed; 3. hypertention disease before embryo transfer; 4. no available embryo for transfer 5. oocyte or sperm donated cycles
combination versus laser treatment only

Conditions: Photoaging

Summary: our objective is to determine the effects of (1) basic skin care regimen + "active" (lytera 2.0) vs. (2) basic skin care regimen only, both groups combined with laser, on the appearance of skin tone and photo-aging on the face.


Eligibility criteria:
inclusion criteria: * healthy adult male and female patients 18 years and older * fitzpatrick skin types i-iv * has at least mild mottled skin tone of the face (score of 2 or more on a 5 point skin tone scale) * has at least 2 areas of the face with significant roughness, dyspigmentation, or fine lines or has all these characteristics in 1 or more areas * willing to refrain from using any other topical products on the face, systemic retinoids, or steroids, facial peels or other facial laser procedures throughout the duration of the study * willing to refrain from any cosmetic procedure including but not limited to facial surgery, dermal fillers, and neuromodulators for the duration of the study * willing to use only the facial skin care product regimen provided for the study * willing to avoid extended periods of sun exposure and the use of tanning beds during the study * willing to have photographs taken of the face to be used de-identified in evaluations, publications, and presentations * for females: proof that they are not pregnant (urine pregnancy test) * english-speaker exclusion criteria: * has any uncontrolled systemic disease (such as autoimmune disorders and connective tissue disorders such as lupus erythematosus or sjogren's syndrome * has any active infection in face * has history of any skin conditions that could interfere with treatment * has used self-tanner recently * is currently participating in another drug research study * is not willing to refrain from using any other topical products such as skin lightening, retinoids, alpha/beta-hydroxyl acids, salicylic acid, vitamins c or d, steroids, or antibiotics on the face or systemic retinoids, steroids, facial peels, neuromodulators, dermal fillers, facial surgery, or other facial laser procedures throughout the duration of the study * for females: is pregnant * non english-speaker

Keywords: skin sun damage photoaging of face skin care laser therapy
femoral preincisional block in acute postoperative pain management of surgery orthopaedic lower limb

Conditions: Surgery

Summary: proper management of acute postoperative pain (dapo) is essential for the recovery of orthopedic surgeries. the blockade of the femoral nerve preincisional (bfp) is simple and its effectiveness increases guided by ultrasound and neurostimulation. objective: to evaluate the effectiveness of bfp in patients undergoing orthopedic surgery of the lower limbs under general anesthesia. methods: a comparative study was conducted, randomized, two groups, surgeries of the hip, femur and knee, asa i-ii, aged 18 years. group b (n = 15) received bfp and ultrasound-guided nerve stimulation with 20 ml of bupivacaine 0.5% plus epinephrine 1: 200,000. group s (n = 15) without blocking. both groups received intravenous analgesia with ketoprofen 100 mg regimen and dipyrone 1g c / 8 hs and balanced general anesthesia. postoperative morphine 0.03 mgr / kgr / weight was administered if eva ≥4


Eligibility criteria:
inclusion criteria: * asa i and ii patients, both sexes, plan for elective orthopaedic surgery of the lower limbs (femur and knee) under general anesthesia exclusion criteria: * patients with any anesthetic or surgical complication * patients with neuromuscular diseases * allergy to any of the drugs used in the study * inability to understand and use a pain scale * also those patients in whom it was not possible to locate anatomical landmarks and / or failed femoral block

Keywords: postoperatory pain orthopaedic surgery femoral block
asthma academy: use of simulation and telehealth to empower family caregivers

Conditions: Caregiver Burnout

Summary: the goal of this project is to implement and evaluate a novel intervention for low-income families to reduce the burden of caregivers of a child with asthma.


Eligibility criteria:
inclusion criteria: 1. must be age 18 or older 2. able to speak and read english or spanish 3. have a smartphone or computer with active service 4. care for a child with asthma between ages 5-12 5. agree to participate exclusion criteria: 1. age less than 18 2. inability to speak and read english or spanish 3. does not have a smartphone or computer with active service 4. child does not have asthma 5. care for a child less than 5 or greater than 12 6. decline to participate 7. prisoners
rebamipide (regular & nanoparticulated) vs. clobetasol in management of methotrexate-induced oral ulceration in rheumatoid arthritis patients

Conditions: Rheumatoid Arthritis

Summary: the aim of this intervention study is to compare the effect of topical rebamipide (regular and nanoparticulated) to topical clobetasol propionate in management of methotrexate induced oral mucositis in patients with rheumatoid arthritis.

a random sample of patients diagnosed with rheumatoid arthritis attending at the rheumatology clinic in faculty of medicine, cairo university hospital, will be enrolled by the investigator in the study in a consecutive order after being examined for methotrexate induced oral ulceration by means of history and clinical examination. since oral mucositis associated with methotrexate include production of free radicals, increase of inflammatory cytokines, and alteration of intracellular signal transduction, this suggests that rebamipide should be useful for its treatment and prevention. thus, this rct will be the first to evaluate the treatment of methotrexate-induced oral mucositis using rebamipide and rebamipide nanoparticles in patients with rheumatoid arthritis.

Eligibility criteria:
inclusion criteria: * patient who agreed to sign the informed consent. * age: 20-70 years old. * gender: males and females * ra patients treated with mtx and suffering from mtx-induced oral ulceration. exclusion criteria: * patients refused to sign the informed consent. * pregnant or lactating females in their child bearing age group. * patients with known or suspected history of hypersensitivity to any of the ingredients of the preparation of the drugs used. * systemic disease: such as uncontrolled diabetes mellitus, auto-immune diseases known to cause oral ulceration, renal or liver dysfunction or any other condition considered risky by the clinician. * patients treated with any medication for the condition at the time of setting. * salivary gland diseases. * malignancy.
multicenter prospective evaluation of radiofrequency for anal fistulas

Conditions: Anal Fistula

Summary: anal fistula treatment is associated with increasing risk of anal incontinence until 40% of cases. new and alternative treatments (glue, advancement flap, plug...) decrease this risk, but with fistula efficacy treatment in 40 to 60% of cases. radiofrequency might destroy fistula tract without lesion of anal sphincter. objective : fistula healing rate and anal continence, 6 and 12 months after radiofrequency procedure. methods : clinical and mri evaluation before, 6 and 12 months after treatment. patients : 50 patients with low, high, complex and crohn disease fistula. an intermediate analysis is expected after the first 20 patients, to verify morbidity. evaluations : * fistula clinical healing 6 and 12 months after procedure * fistula mri healing 12 months after procedure * anal continence before and after procedure * feasibility og radiofrequency procedure * morbidity * success and failure prognostics factors of this procedure

: anal fistula treatment is associated with increasing risk of anal incontinence until 40% of cases. new and alternative treatments (glue, advancement flap, plug...) decrease this risk, but with fistula efficacy treatment in 40 to 60% of cases. radiofrequency might destroy fistula tract without lesion of anal sphincter. objective : fistula healing rate and anal continence, 6 and 12 months after radiofrequency procedure. methods : clinical and mri evaluation before, 6 and 12 months after treatment. patients : 50 patients with low, high, complex and crohn disease fistula. an intermediate analysis is expected after the first 20 patients, to verify morbidity. evaluations : * fistula clinical healing 6 and 12 months after procedure * fistula mri healing 12 months after procedure * anal continence before and after procedure * feasibility og radiofrequency procedure * morbidity * success and failure prognostics factors of this procedure schedule : * first inclusion march 2017 * last inclusion march 2018 * evaluations until march 2019.

Eligibility criteria:
inclusion criteria: * adult patient agreeing to participate in the study and signing the consent to participate * patients with an anal fistula previously drained, without diverticulum\> 10 mm in mri after drainage. * for women of childbearing age, they must have a negative urine pregnancy test exclusion criteria: * patient minor, * patients who are linguistically or psychologically unable to understand the information given and to give informed consent, * patient incapable, in the opinion of the investigator, to complete the self-questionnaires, * against-indication to radiofrequency treatment (infectious anal pathologies, anal fissures, residual staples of previous treatment longo, * pregnant woman, * patient carrying a pacemaker, * patients participating in another clinical study, * against indication to the realization of an mri, * patient with a fistula with insufficient drainage, against indicating the removal of the stem (congestive fistula, oozing, with internal and / or external congestive orifices).

Keywords: anal fistulas evaluation of radiofrequency
improving sensitivity of urine cytology for bladder cancer

Conditions: Bladder Cancer

Summary: can a commercially available vibrating chair increase the number of urothelial cells in a urine sample of healthy participants non-invasively? the investigators plan is participants will alternate 15 minutes of drinking eight fluid ounces of water and 15 minutes of sitting in the vibrating chair for one hour. the control group will alternate 15 minutes of drinking eight fluid ounces of water and 15 minutes of sitting in a non-vibrating chair for one hour. then, urine samples will be collected and examined for urothelial cell concentration for both groups.


Eligibility criteria:
inclusion criteria: * only adult male subjects who will not have surgery within a period of 2 weeks. * over the age of 18 * have had a confirmed diagnosis of stage 0-4 transitional cell carcinoma within the last 30 days exclusion criteria: * cognitive impairment resulting in the inability to give informed consent * lack of spoken and written english resulting in the inability to give informed consent * presence of infectious disease * insulin dependent diabetes mellitus * endogenous osteosynthetical material implants * knee or hip prosthesis * pacemaker * epilepsy * musculo-skeletal disorders * weight in excess of 250 pounds * poor circulation

Keywords: cytology whole body massage vibration
bladder full or empty for pelvic radiation therapy

Conditions: Pelvic Neoplasm

Summary: the present study evaluates empty and full bladder protocols for radiation therapy of genitourinary (gu), gynecological (gyn), and gastrointestinal (gi) malignancies of the pelvis.

pelvic radiation therapy plays a key role in the treatment of common genitourinary (gu), gynecological (gyn), and gastrointestinal (gi) malignancies of the pelvis. prior to starting a course of radiation therapy, patients undergo a ct simulation that allows for computer-based optimization of radiation dose delivery to target while simultaneously minimizing dose to surrounding normal tissues, such as the bladder and rectum. commonly, physicians instruct patients undergoing pelvic radiation therapy to present with a reproducibly full bladder for the simulation and for each subsequent treatment session with the hope that increased distance between normal tissues (anterior bladder wall and bowel) and treatment target will limit toxicity. however, treating with a full bladder can result in wide variations in bladder volume. often patients are unable to reproduce the bladder distention achieved at simulation, especially as typical urinary symptoms related to radiation develop during treatment. as the initial ct simulation is used to calculate dose distribution, bladder volume changes can affect radiation dose distribution to the bladder itself as well as adjacent pelvic organs. given the challenges and uncertainties of treating with a full bladder, there has been increasing interest in bladder empty protocols. retrospective, non-randomized, single-institution studies demonstrate that bladder empty protocols reduced absolute variation in bladder volume during treatment, had minimal impact on treatment related toxicity, and had non-inferior biochemical progression free survival, gi toxicities, and gu toxicities. however, prospective data is very limited. the present study plans to fill this knowledge gap by randomizing study participants to empty and full bladder protocols for simulation and radiation therapy.

Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form * stated willingness to comply with all study procedures and availability for the duration of the study * persons, aged at least 18 years * deemed eligible to undergo curative intent radiation therapy for primary gu, gi, or gyn malignancy of the pelvis. * for participants able to become pregnant: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation * for participants able to cause a pregnancy: use of condoms or other methods to ensure effective contraception with partner exclusion criteria: * pregnancy * tumor invading the bladder, as judged by the enrolling physician based on available clinical information * contraindications to radiotherapy, including crohn's disease and active connective tissue disorders such as scleroderma or uncontrolled lupus * prior radiation therapy to an area requiring treatment in the present study

Keywords: malignancy of the pelvis bladder radiation therapy
zinc supplementation and severe and recurrent diarrhea

Conditions: Diarrhea

Summary: evaluating the impact of 3 months daily zinc supplementation on incidence of severe and recurrent diarrhea in 6 to 36 months age children in bandarabbaas

evaluating the impact of 3 months daily zinc supplementation on incidence of severe and recurrent diarrhea in 6 to 36 months age children in bandarabbaas in 2009

Eligibility criteria:
inclusion criteria: * all 6 to 36 months old children without diarrhea at the time of study and without disease such as celiac * inflammatory bowl disease and hypersensitivity to milk exclusion criteria: * diarrhea at the time of the study and background disease such as celiac, ibd or hypersensitivity to milk

Keywords: zinc supplement diarrhea sever diarrhea
does notch regulate glioma proliferation ?

Conditions: Glioma

Summary: the investigators showed in 2015 (guichet et al) that the notch1 pathway has an anti-proliferative role on glial brain tumors. in this project, the investigators investigated which genes downstream of notch1 pathway activation produce the anti-proliferative effect. the investigators hypothesized that the snai2 and tal1 genes act downstream of notch1

main objectives: to examine the expression of tal1 and snai2 in protein extracts and glioma sections of different grades (glioblastomas and diffuse low-grade tumors). to examine the effect of overexpression of tal1 and snai2 in high grade glioma cultures. to show the expression of tal1 and snai2 by tumor cells by fish technique. show that tal1 and snai2 could be regulated by endothelial cells

Eligibility criteria:
inclusion criteria: * patient ≥18 years old * patient affected with brain glioma classified according to who 2016 classification exclusion criteria: * patient who reject the study protocol * radiotheray or chemotherapy treatment

Keywords: pathologist-graded gliomas
study in patients with asthma

Conditions: Asthma

Summary: the purpose of this study is to determine which dose of the investigational drug is the most safe and effective in the treatment of asthma compared to the control drug.


Eligibility criteria:
inclusion criteria: * patients with a history of asthma exclusion criteria: * current asthma exacerbation or recent asthma exacerbation, requiring hospitalization * history of smoking * debilitating systemic and/or life-threatening diseases.

Keywords: asthma formoterol fumarate