Kornimate/medical-research-clean huggingface dataset:
observational study of lamotrigine

Conditions: Epilepsy

Summary: the purpose of this study is to assess efficacy, safety and tolerability of lamotrigine as used in a natural clinical setting, to examine the positive effects of lamotrigine, and the reasons why some patients choose to continue or discontinue lamotrigine.

there have been numerous randomized, double-blind controlled trials demonstrating the value of lamotrigine in the treatment of seizures. however, randomized trials take place in artificial experimental conditions with many restrictions imposed. there hasn't been much focus on positive effects on the patient, such as improvement in mood and level of alertness related to the drug. other factors related to quality of life that affect the decision to continue or discontinue the drug are also important. anecdotal experience suggests that lamotrigine is associated with increased alertness, enhanced energy levels and improved general sense of well-being. observational studies that promote awareness of such distinguishing features and other aspects of efficacy are essential for guiding decision-making when prescribing anti-epileptic drugs.

Eligibility criteria:
inclusion criteria: * patients who are about to be prescribed lamotrigine as an appropriate treatment for their epileptic disorder exclusion criteria: * patients with mental retardation

Keywords: epilepsy quality of life
a case report of a patient with intellectual disability and neurogenic bladder complicated with sepsis

Conditions: Sepsis Bacterial

Summary: a case report of a patient with intellectual disability and neurogenic bladder complicated with sepsis

to summarize the individual care experience of a patient with neurogenic cystitis with sepsis and mental retardation. the main points of nursing care include: conducting personalized nuring care for early sepsis; carring out care for urinary incontinence and urinary tract infection; bulinding health-management plans with family members; and a full course of psychologic diversion that alleviates negative feelings among patients and family members.

Eligibility criteria:
inclusion criteria: dysgnosia neurogenic bladder pyohemia exclusion criteria: intellectually normal person no urinary infection

Keywords: intellectual disability；neurogenic bladder；sepsis ；
awareness, care & treatment in obesity management (action) study

Conditions: Metabolism and Nutrition Disorder; Obesity

Summary: the action (awareness, care, and treatment in obesity management) study aims to identify perceptions, attitudes, behaviours, and potential barriers to effective obesity care across three respondent types: 1) people with obesity, 2) healthcare providers and 3) employer representatives in the us. data is collected via online surveys using a cross-sectional, us-based stratified sample design.


Eligibility criteria:
inclusion criteria: * general population * agrees to ae reporting * age at least 18 years * lives in the us * current bmi at least 30 kg/sqm * health care professionals * agrees to ae reporting * physician and board certified or np/pa * facility located in the u.s. and not vermont * spends at least 70% of time in direct patient care * seen at least 100 patients in past month * seen at least 10 patients in past month needing weight management * in practice 2-35 years * not competitively employed * primary care providers * specialty is fp, im, gp * less than 50% patients seen for obesity * obesity specialists * obesity medicine or weight loss specialist or at least 50% of patients seen for obesity * in practice 2-35 years * employers * age at least 18 years * works in the us * director, administrator, chro, vp or other title * responsible for making or influencing decisions about health insurance or health and wellness programs * company employs 500 or more full-time employees * believes there is a weight issue at their company * not competitively employed exclusion criteria: - none
the diagnostic value of shear wave elastography and viscosity imaging techniques in diabetic peripheral neuropathy

Conditions: Diabetic Peripheral Neuropathy (DPN)

Summary: the main objective of this observational study is to evaluate the diagnostic value of multimodal ultrasound for diabetic peripheral neuropathy (dpn). the questions it aims to address are: (1) to compare the differences in various parameters between the dpn group, non-dpn group, and healthy control group; (2) to explore the diagnostic efficacy of each parameter for dpn and establish a combined model.


Eligibility criteria:
inclusion criteria:individuals aged 18 to 75 years without diabetes - exclusion criteria:individuals without peripheral neuropathy. -
synergizing home health rehabilitation therapy

Conditions: Frailty; Frail Elderly; Occupational Therapy; Activities of Daily Living; Home Health Care; Functional Status; Physical Functional Performance; Rehabilitation; Treatment Outcome; Health Services for the Aged

Summary: the objective of this project is to pilot test an adl (activities of daily living)-enhanced program as an adjuvant therapy to usual home health rehabilitation to improve patient outcomes. the project will compare the adl-enhanced program plus usual care with usual care using an rct design in home health patients.

regaining the ability to take care of oneself after an illness or medical episode is critical for home health patients to maintain independent living at home. an adl-enhanced program may augment the effect of home health rehabilitation therapy to support patients' self-care outcomes. patients will be randomly assigned to two groups: one will receive the adl-enhanced program with usual home health care, and the other will receive usual home health care. researchers will compare outcomes in self-care activities and physical performance between the two groups to determine the effect of the adl-enhanced program.

Eligibility criteria:
patients are eligible if they * are 65 years of age over older * are medicare beneficiaries * are referred for skilled rehabilitation services at the partnered home health agency * have three or more comorbidities patients are ineligible if they have * acute fractures with surgical or weight-bearing restrictions, * elective joint replacement surgery * lower-extremity amputation * active treatment for cancer diagnosis * ongoing dialysis treatment * acute cardiac surgery, * acute stroke or a major neurologic disorder limiting motor movements * terminal stage of congestive heart failure * a referral to hospice care * severe cognitive deficits limiting verbal communication.

Keywords: rehabilitation
creating an innovative ai-based technology tcract for designing and optimizing t-cell receptors (tcr) for use in cancer immunotherapies

Conditions: Colon Cancer; Cancer

Summary: the project objective is to create an innovative ai-based (artificial intelligence) in silico technology for the design and optimization of t-cell receptors (tcrs) capable of recognizing specific tumor antigens presented on human leukocyte antigen (hla). the technology will be based on bioinformatics (including molecular modelling) and artificial intelligence (including predictive, generative and optimization models). project tasks are dedicated to the implementation of individual technological components (including the database necessary for their preparation) and to performing in vitro evaluation rounds to optimize the technology. integration, within an in silico technology, of processes which currently require huge amounts of in vitro laboratory experiments that are necessary for bringing new tcr-based cancer immunotherapies into clinical trials: * finding appropriate tcrs targeting cancer neoantigen presented on a hla molecule (phla) * testing for potential tcr toxicity (targeting self antigens presented on healthy tissues) * optimization of phla:tcr binding affinity and toxicity.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of advanced resectable colorectal cancer (active stage ii, iii or iv) * histopathologically confirmed as adenocarcinoma * age 18 or over * being able to understand and sign the informed consent form (icf) * qualification for resection within 3 months from w0 or condition after primary tumor resection, not longer than 5 years from surgery exclusion criteria: * mucinous colorectal adenocarcinoma * canal and anal edge cancer, * adenocarcinoma of the appendix, * patients treated with neoadjuvant therapy or radiation therapy in the 3 months prior to study enrollment. * patients treated with systemic chemotherapy in the 3 months prior to study enrollment. * histopathological diagnosis other than adenocarcinoma * remission * history of inflammatory bowel diseases * pregnancy * hiv infection * active infection with hepatitis b and c viruses * leukocytopenia

Keywords: immunology tcr ffpe pbmc colon cancer immuno-oncology cancer oncology
a clinical trial of fecal microbiota transplantation in a population with obsessive-compulsive disorder

Conditions: Obsessive-Compulsive Disorder

Summary: obsessive-compulsive disorder (ocd) is a psychiatric condition marked by recurrent intrusive thoughts (obsessions) and ritualistic behaviors aimed at reducing distress (compulsions). while there exist a number of medications to treat this illness, half of those who need them either do not respond or can not tolerate current medications because of side effects. therefore, there is an urgent need to develop new ways to treat this illness. one of the areas being explored as a potential option is based on what is now known as a strong link between the bacteria that live in our gut and the brain. research has shown that a fecal transplant of the gut bacteria from healthy donors is able to improve health outcomes for people with depression and the investigators now want to expand this into ocd, given a known link between this condition and bacterial infection. to do this the investigators will use both the standard methods of bacterial identification via stool analysis, which looks at large bowel changes, and compare it to the small intestine microbiome aspiration (simba) system, a small capsule that when swallowed allows a fluid sample to be collected from the participants' small intestine. this work will help the investigators assess the benefits of fecal transplant in ocd, and more importantly, identify how transplant changes the system, utilizing a novel technology to move the field forward.


Eligibility criteria:
inclusion criteria: * adults who have a primary diagnosis of ocd * on a stable appropriate dose of (ssri) treatment for at least 12 weeks prior to baseline * insufficient response to current ssri treatment indicated by persistence of symptoms. exclusion criteria: * participant meets diagnostic criteria for substance use, eating disorder, schizophrenia, or schizoaffective disorder * suicidality * regular intake of antibiotics, prebiotics, or probiotics * clinically diagnosed with ibd, crohn's disease, ulcerative colitis, or celiac disease * immune suppression * intestinal obstruction * oropharyngeal dysphagia or other swallowing disorder * \< 2 bowel movements per week * breastfeeding, pregnant or seeking to get pregnant during the course of this study

Keywords: ocd microbiome fmt gut bacteria
virtual reality approach in subacromial impingement syndrome

Conditions: Shoulder Impingement Syndrome; Virtual Reality; Rehabilitation; Subacromial Impingement Syndrome

Summary: the aim of our study is to investigate the effects of game-based virtual reality exercise added to conventional physiotherapy and rehabilitation program in patients with subacromial impingement syndrome (sis). in order to evaluate its effectiveness, assessment of pain, range of motion and disability will be applied.

subacromial impingement syndrome (sis) is the result of contraction of the structures passing through the subacromial area. problems in upper limb function in people with sis adversely affect quality of life and functional independence of the patients. recovery of restricted daily life functions (such as dressing, personal care, eating and body care) is one of the main goals of physiotherapy and rehabilitation in sis and currently, conventional physiotherapy and rehabilitation methods are most commonly used. the main purpose of this method is to reduce pain, increase range of motion and muscle strength. with the developing technology various virtual reality applications have begun to take place in physiotherapy and rehabilitation programs recently. these virtual reality applications are used to motivate the patient and keep their interest in the rehabilitation. in addition, the diversity of virtual reality applications is increasing day by day so that participation of the patients and the interest in the treatment can be increased. various measurements of the user's performance can be transferred to the clinician simultaneously with these systems. also for most of these systems exercise modes, difficulty and duration are programmable so that the training sessions can be varied. the aim of our study is to investigate the effects of game-based virtual reality exercises added to conventional physiotherapy and rehabilitation program in patients with sis.

Eligibility criteria:
inclusion criteria: * volunteered to participate in the study * aged 18-65 years, exclusion criteria: * any visual or hearing problem, * other neurological, orthopedic or rheumatic problems that may restrict shoulder motion or cause pain, * having a physical disability or uncontrolled chronic systemic disease, * major trauma, * treatment for shoulder problems within the last 6 months, * history of epileptic attacks

Keywords: subacromial impingement syndrome physiotherapy and rehabilitation virtual reality technologic rehabilitation
aimn multicenter study: staging of lymphomas using pet/ct

Conditions: Lymphoma

Summary: in recent years, the introduction of pet/ct tomographs (which have now almost completely replaced tomographs equipped with pet alone), has allowed a significant increase in diagnostic accuracy in the majority of tumors. however, in order to reduce the radiation doses, administering ct images are acquired for patients at a low dose (generally 60ma 120kv) without the use of contrast agents. this prudential attitude, however, makes it essential to carry out "diagnostic" ct investigations which, at the end of the diagnostic process it leads to an increase in the dose administered for the patient rather than to savings. this study aims to evaluate the possible advantages in diagnostic, economic and quality of life terms of pet/ct performed with diagnostic ct with intravenous contrast medium, with the aim of benefiting the neoplastic patient in the diagnostic process by optimizing (from a temporal and dosimetric point of view ) the diagnostic procedures to which it is subjected. it is expected that the integrated pet/ct procedure can facilitate the process of staging the neoplasm and that this procedure can have a positive impact on the patient's quality of life while also reducing the costs incurred in terms of time and money.


Eligibility criteria:
inclusion criteria: * established lymphoma (non-hodgkin's lymphoma and hodgkin's disease) being staged; * performing the pet/ct examination within two weeks of diagnosis and before treatment; * signing of the informed consent. exclusion criteria: * patients \<18 years; * patients who have not signed the informed consent; * execution of previous anti-inflammatory or anti-inflammatory therapies in the 4 weeks preceding the pet exam.
therapy and outcome of prolonged veno-venous ecmo therapy of critically ill ards patients.

Conditions: Extracorporeal Membrane Oxygenation Complication; Outcome, Fatal

Summary: in the context of the coronavirus (covid-19) pandemic, healthcare systems worldwide faced an unprecedented shortage of severe ards. critically affected patients were treated with veno-venous extracorporeal membrane oxygenation (vv-ecmo) for complete respiratory failure early in the pandemic. due to a shortage of resources in the sense of terminal equipment and adequately trained personnel with appropriate expertise in many countries and regions, a strict selection of suitable patients was made. repeatedly, it was observed that patients under vv-ecmo also needed several weeks to recover sufficiently to generate device sufficient gas exchange. due to the scarcity of vv-ecmo resources outside of the pandemic, the question arose whether a prolonged therapy still holds a sufficient prospect of success and what the course of treatment of such patients would be like.


Eligibility criteria:
inclusion criteria: veno-venous extracorporeal membrane oxygenation exclusion criteria: veno-arterial extracorporeal membrane oxygenation
intranasal dexmedetomidine sedation and analgesia during pediatric emergency room procedures

Conditions: Pain; Anesthesia

Summary: the study objective is to determine if intranasal dexmedetomidine is a safe and effective sedative drug during small painful procedures in the pediatric emergency room. patients of the pediatric emergency room at oulu university hospital with any medical condition requiring a small painful procedure like i.v. cannulation or lumbar puncture are asked to join the investigator's study if they would seem to benefit from a sedative drug during the procedure. patients are randomly assigned to treatment group receiving intranasal dexmedetomidine 1µg/kg and to placebo group receiving 4,5% saline solution. the primary outcome is the success of the procedure. cardiovascular and respiratory effects, the pain experienced by the patient, sedation scores and duration of crying are also monitored.


Eligibility criteria:
inclusion criteria: * pediatric patients aged 1-12 years at the oulu university hospital emergency room who would benefit from sedative medication during small painful procedures like i.v. cannulation or lumbar puncture are asked to take part in our study exclusion criteria: * allergy to dexmedetomidine or any supplementary elements of the dexdor®-solution * ii or iii degree av-blockage without pacemaker * uncontrollable hypotension * stroke * critically ill patients who are admitted to the picu * patients with clear cardiac or respiratory dysfunction * lowered level of consciousness * patients with increased risk of apnoeic events due to neurologic or metabolic conditions or extreme obesity * a single patient can only take part in this study once.

Keywords: pediatrics sedation emergency room sedation intranasal sedation dexmedetomidine intranasal dexmedetomidine children pediatric pediatric sedation
integrating palliative and critical care (ipacc) study

Conditions: Any Disease Causing Death in the ICU or Within 24 Hours of Discharge From the ICU

Summary: the purpose of this research study is to evaluate an intervention to improve the care given to patients who are dying in the intensive care unit (icu) and their families. this study is a multi-center randomized trial of a multi-faceted quality improvement intervention designed to improve the quality of palliative and end-of-life care in the icu setting. the intervention targets the hospital and the outcome evaluation occurs at the level of the individual patient and family with surveys completed by family members and nurses as well as standardized medical record review.

because of the severity of illness, the intensive care unit (icu) is a setting where death is prevalent and where the majority of deaths involve decisions to withhold or withdraw life-sustaining therapies. there is substantial data to suggest that the quality of end-of-life care in the icu is poor. many patients die with moderate to severe pain, physicians are often unaware of patients' wishes regarding end-of-life care, and the care patients' receive is often not consistent with their treatment preferences. our study aims to evaluate the effectiveness of a multi-faceted intervention to improve the quality of care for patients dying in, or shortly after a stay in, the icu using a randomized controlled study of 12 hospitals. in addition we plan to examine the variability in, and predictors of, the quality of dying and end-of-life care in community hospital icus with the purpose of identifying the current quality of end-of-life care and the institutional, clinician, and patient factors associated with the quality of this care. we will evaluate the successful and unsuccessful components of the intervention and describe the institutional and clinician facilitators and barriers to the intervention's implementation, with a focus on identifying interventions to improve care for the dying at other sites.

Eligibility criteria:
inclusion criteria: * patients, family members, nurses, and clinician evaluators patients are eligible if they are: * in the icu for a minimum of 6 hours and, * if they die in an icu or within 24 hours of transfer out of the icu. family members or significant others are eligible if: * they were involved with the patient who has died. nurses are eligible if: * they cared for an eligible patient on either the shift during which the patient died or the shift preceding the death. clinicians are eligible to evaluate the intervention components if they: * work in a study icu and * participate in any of the intervention components. exclusion criteria: * inability to read english well enough to complete the surveys * under 18 years of age.

Keywords: end-of-life issues talking with your doctor coping with chronic illness
glycemic index and polyphenol bioavailability of potatoes

Conditions: Diabetes; Insulin Resistance

Summary: the purpose of this study is to determine the glycemic index of four varieties of potatoes and to determine the bioavailability of polyphenols contained in these potatoes.

ten healthy persons will have a fasting blood sample drawn and asked to randomly consume a 50g glucose drink (2 occasions), or 50g carbohydrate equivalent of cooked purple, red, yellow and white potatoes. further blood samples will be obtained at 15,30, 45, 60, 90, 120, 180, 240 mins. bloods from the first 2 hours will be analyzed for glucose and insulin to determine the glycemic response. hourly blood samples will be analyzed for polyphenol to determine the bioavailability of polyphenols from the different potato variety. urine samples will be collected before ingestion of the food items and again at 4 hours, and will be used to determine polyphenol bioavailability.

Eligibility criteria:
inclusion criteria: * healthy, non-smoker on no medication * normal glucose tolerance * willing to have a catheter inserted in forearm exclusion criteria: * abnormal glucose tolerance * abnormal bmi * on medication for a chronic disorder

Keywords: glycemic index anthocyanin potato polyphenol