Kornimate/medical-research-clean huggingface dataset:
research study to investigate how well semaglutide works compared to liraglutide in people living with overweight or obesity

Conditions: Overweight; Obesity

Summary: this study will look at participants' body weight from the start to the end of the study. the study will last for about 1½ years. this is to compare the effect on body weight in people taking semaglutide once a week or people taking liraglutide once every day. participants will either get semaglutide, liraglutide or "dummy" medicine. which treatment is decided by chance. participants who receive semaglutide or semaglutide "dummy" medicine will need to take 1 injection once a week. participants who receive liraglutide or liraglutide "dummy" medicine will need to take 1 injection once daily. the study medicine is injected with a thin needle in a skin fold in the stomach, thigh or upper arm. during the study participants will have talks with study staff about eating healthy food and how to be more physically active. participants will have 16 clinic visits and 7 phone calls with the study doctor. at 4 of the clinic visits participants cannot eat and drink (water is allowed) for 8 hours before the visit. women cannot take part if pregnant, breast-feeding or planning to become pregnant during the study period.


Eligibility criteria:
inclusion criteria: * male or female, age 18 years or older at the time of signing informed consent * body mass index (bmi) equal to or above 30.0 kg/m\^2 or equal to or above 27.0 kg/m\^2 with the presence of at least one of the following weight-related comorbidities (treated or untreated): hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease * history of at least one self-reported unsuccessful dietary effort to lose body weight exclusion criteria: * hba1c equal to or above 48 mmol/mol (6.5%) as measured by the central laboratory at screening * history of type 1 or type 2 diabetes mellitus * a self-reported change in body weight of more than 5 kg (11 lbs) within 90 days before screening irrespective of medical records
investigation of the effect of physical activity level on sleep quality and fatigue in academicians

Conditions: Physical Activity; Sleep; Fatigue

Summary: physical activity is closely associated with well-being condition and health development. the sleep quality and fatigue levels of individuals are also important components of health. within the scope of our study, it is aimed to investigate the physical activity levels, sleep quality and fatigue levels of the academicians, who are generally working on a desk and we think that they live a sedentary life. within the scope of this study, academicians were asked to respond to , international physical activity questionnaire-short form (ipaq-short form), general evaluation form, pittsburg sleep quality index (psqi) and fatigue severity scale (fss) .

the aim of this study is to investigate that the effect of physical activity level on sleep quality and fatigue in academicians. first of all, a form including the purpose of the study, demographic information, daily working hours and assignment durations, was arranged; then obtaining general information about academicians who participated in the study and the physical activity levels of the individuals with international physical activity questionnaire-short form (ipaq-short form); sleep quality with the pittsburg sleep quality index (psqi); fatigue levels with fatigue severity scale (fss) were planned to be measured. on-line communication was preferred as a data collection tool for all these assessments. in order to prevent bias in the results of the study, it was planned to transmit the questionnaire on-line to the academicians working in any program of any higher education institution. in this way, the voluntary involvement of the participant or any other threat to abuse was prevented. in other words, it was planned to ensure that individuals answer or don't respond the form on a purely voluntary basis.

Eligibility criteria:
inclusion criteria: volunteering, to work as academicians in any department of any higher education institution. exclusion criteria: refuse to participate in the study, not being an academician

Keywords: academician physical activity level sleep quality fatigue
effectiveness of clemastine fumarate + dexamethasone compared to dexchlorpheniramine maleate in eczema treatment

Conditions: Eczema

Summary: atopic dermatitis is a recurrent pruritic skin disorder which has a significant morbidity and impaired quality of life due specially pruritus and physical visible skin lesions. the propose of this trial is evaluate the effectiveness of clemastine fumarate 1, 0 mg/g + dexamethasone 0, 5 mg/g compared to dexchlorpheniramine maleate 10 mg/g in eczema treatment.

study design: • double blinded, superiority, prospective parallel-group, intend to treat trial. study design: * experiment duration: 22 days * 2 visits (days 1,7,15 and 22) * reducing eczema area and severity index evaluation * adverse events evaluation

Eligibility criteria:
inclusion criteria: 1. patients must be able to understand the study procedures agree to participate and give written consent. 2. patients with acute or sub-acute eczema. 3. presence of symmetric lesions to compare on side to the other. exclusion criteria: 1. pregnancy or risk of pregnancy. 2. lactation 3. use of anti-inflammatory or immunosuppressive drugs (last 30 days prior to the study). 4. sunlight over exposure in the last 15 days. 5. any pathology or past medical condition that can interfere with this protocol.

Keywords: dermatitis dermatitis, atopic
acetaminophen for the reduction of oxidative injury in severe sepsis

Conditions: Severe Sepsis

Summary: cell-free hemoglobin can be measured in the plasma of patients with sickle cell anemia, hemodialysis, after red blood cell transfusion, and in patients with sepsis. cell-free hemoglobin in these patient population has been associated with poor outcomes, including an association with an increased risk of death. acetaminophen may have a protective effect in these patient populations by inhibiting hemoprotein-mediated lipid peroxidation. the purpose of the present trial is to study the effect of acetaminophen on lipid peroxidation in adults with severe sepsis and detectable cell-free hemoglobin. the primary hypothesis is that systemic markers of oxidative stress and lipid peroxidation, as measured by f2-isoprostanes, will be significantly lower in patients with severe sepsis and detectable cell-free hemoglobin who receive acetaminophen compared to placebo. the secondary hypothesis is that patients with severe sepsis and detectable cell-free hemoglobin treated with acetaminophen will have better clinical outcomes, including decreased incidence of acute kidney injury and lower rates of hospital mortality, compared to those who receive placebo.


Eligibility criteria:
inclusion criteria: * males and female \>=18 years old * admitted to an intensive care unit * severe sepsis * detectable plasma cell-free hemoglobin exclusion criteria: * patients who received acetaminophen in the past 48 hours prior to enrollment * intolerance or allergy to acetaminophen * measured ast/alt \>400 u/l in the 24 hours prior to enrollment * chronic liver disease defined by a child-pugh score \>4 * cannot swallow or have no enteral feeding access * patients with no detectable cell-free hemoglobin * patients transitioned to palliative care * pregnant patients or women of childbearing potential without a documented pregnancy test
bridging the adherence gap in internet interventions: a randomized controlled trial protocol

Conditions: Adherence, Treatment; Job Stress

Summary: low adherence in self-guided internet interventions might lead to worse outcomes. this randomized controlled trial aims to test whether adherence can be improved if self-efficacy regarding adherence to internet interventions is boosted before the intervention starts. it is expected that enhancing this specific type of self-efficacy will increase people's adherence and help them fully benefit from the intervention, namely experience lower job stress and higher work engagement.

low adherence can lead to poor outcomes in self-guided (i.e., self-administered) internet interventions that is psychological programs designed to improve mental health. one modifiable personal factor that may improve adherence is context-specific self-efficacy. in this two-arm randomized controlled trial, participants (medical students, n = 720) will undergo an internet intervention called med-stress student designed to enhance resources such as self-efficacy to cope with stress and perceived social support. in the experimental group, med-stress student will be preceded by an exercise designed to boost self-efficacy to adhere to this internet intervention. in the control condition, participants will only access med-stress student. conditions will be compared on adherence as well as on the intervention outcomes (i.e., job stress and work engagement) at posttest, and at six-month, and one-year follow-ups.

Eligibility criteria:
inclusion criteria: * must be at least 18 years old * must be a medical student or intern who already has direct contact with patients there are no criteria for exclusion.

Keywords: job stress adherence work engagement self-efficacy
effect of paracetamol, pregabalin and dexamethasone on pain and opioid requirements in patients after hip operations

Conditions: Pain; Postoperative

Summary: patients scheduled for primary total hip replacement needs postoperative pain treatment: i.e. morphine. unfortunately morphine has side-effects: nausea, vomiting, sedation and dizziness, which is unpleasant for the patients and sometimes keeps them at bed longer time than needed. we investigate in new combinations of analgesics for postoperative pain, hoping to minimize the need for morphine and improve the patients pain score after operation.

we investigate the effect of paracetamol versus paracetamol + pregabalin versus paracetamol + pregabalin + dexamethasone on pain and morphine usage in the first 24 hours postoperatively in patients getting a new hip alloplastic.

Eligibility criteria:
inclusion criteria: * patients scheduled for primary total hip replacement in spinal anaesthesia * between the age of 55 and 75, * asa 1-3, and with * bmi between 18 and 35. exclusion criteria: * are unable to cooperate; * does not speak danish; * has allergy for drugs used in the trial; * has drug and/or medicine abuse; * epilepsy; * diabetes treated with medicine; * treatment with systemic steroids within 4 weeks prior to the operation; * daily use of antacids; * daily use of analgesics except for nsaid, cox2 inhibitors and paracetamol; * known kidney disease; * use of antidepressants

Keywords: total hip replacement pregablin dexamethasone multimodal postoperative analgesia.
obese patients with or without comorbidities (rio-north america)

Conditions: Obesity; Weight Loss

Summary: to assess the effects of weight loss and weight maintenance over a period of two years when prescribed with a hypocaloric diet in obese patients with or without comorbidities


Eligibility criteria:
* stable weight (variation of less than 5 kg within 3 months prior to screening visit) * bmi (body mass index) of 30 or greater in patients with or without comorbidities, or bmi greater than 27 in patients with treated or untreated hypertension and/or treated or untreated dyslipidemia

Keywords: weight loss obesity weight reduction overweight
hypnosis and meopa in regional painful syndrome complex

Conditions: Algodystrophy of Hand

Summary: relation between hypnosis and meopa on algodystrophy.


Eligibility criteria:
inclusion criteria: * regional painful syndrome complex exclusion criteria: * deaf people
wearable devices to monitor seizures in autoimmune epilepsy

Conditions: Autoimmune Epilepsy; Healthy

Summary: the purpose of this research is to search for reproducible changes in a wide range of physical signals, including heart rate, muscle tone and activity and eeg before and at the onset of seizures in patients with epilepsy.


Eligibility criteria:
inclusion criteria: * patients diagnosed with or suspected of having autoimmune epilepsy. * normal controls - cognitively normal subjects without epilepsy exclusion criteria: • cognitive or psychiatric condition rendering patient unable to cooperate with data collection or manage and recharge smart watch and tablet computer devices. presence of open or healing wounds near monitoring sites (infection risk).
airway iga: respiratory tract iga levels in anesthetized patients undergoing elective surgical procedures

Conditions: Healthy; Malnutrition

Summary: the purpose of the study is to determine the variability of airway iga levels in anesthetized, well-nourished and malnourished patients undergoing elective general surgical procedures and the effect of gender and race on this baseline variable. the hypothesis is that airway iga levels are lower in malnourished than in well-nourished patients.


Eligibility criteria:
inclusion criteria: * undergoing surgery via general anesthesia exclusion criteria: * patients with a history of asthma or documented airway irritability * patients who have undergone previous pulmonary resection * patients receiving cardiac medications for arrhythmias.
5-day preoperative radiation for soft tissue sarcoma

Conditions: Soft Tissue Sarcoma

Summary: the purpose of this study is to examine the safety and efficacy of an abbreviated course of preoperative radiation, given over five days, for patients with soft tissue sarcoma of the extremity, trunk or retroperitoneum. this is in contrast to standard preoperative radiation, which is given over 25 days.


Eligibility criteria:
inclusion criteria: 1. histologically confirmed soft tissue sarcoma of the extremity, trunk or retroperitoneum. 2. has been offered preoperative radiation and surgery as part of standard-of-care treatment 3. age ≥ 18 4. kps ≥ 70 or ecog 0 to 2 5. life expectancy ≥ 6 months 6. if a woman is of childbearing potential, a negative serum or urine pregnancy test must be documented. 7. ability to understand and the willingness to personally sign the written irb approved informed consent document. exclusion criteria: 1. history of prior radiation to the area to be treated. 2. active use of other anti-cancer investigational agents. 3. planned use of concurrent chemotherapy, targeted therapy, or immunotherapy with radiation therapy (defined as the time interval starting 1 week before the first and last fraction of radiation therapy and surgery). 4. pregnancy.
chronic sleep restriction

Conditions: Other Conditions That May Be A Focus of Clinical Attention

Summary: sleep is a physiological state considered essential for health and human survival. the prevalence of chronic sleep restriction has increased in modern society, as well as the effects of the same health concerns about various aspects, including the physiological and neurobehavioral. the objective of this study is to identify the neurobehavioral and physiological responses of healthy men with different needs of total sleep time (tst) submitted to chronic sleep restriction. participants in this study will be 30 male volunteers, aged between 20 and 35 years, divided into three groups: group 1 (n = 10) with tst ≤ 6 hours (h), group 2 (n = 10) with tst ≥ 9h and group 3 (n = 10): tst with between 7 and 8h. the tst will be established by the constant and continuous use of actigraphy for 10 days prior to the onset of the experimental protocol. all volunteers will undergo medical and polysomnography (psg) examination to detect the presence or not of changes in sleep as well as other health problem that prevents their participation in the study. the experimental protocol consists of a basal night of sleep, five consecutive nights of chronic sleep restriction to 25% of tst in the beginning night and a night of recovery, which will be allowed to sleep the sleep pattern. each night will have psg monitoring and when wake up in each day, the volunteer will undergo tests to assess the physiological and neurobehavioral variables. the significance level will be 5% (p ≤ 0.05).


Eligibility criteria:
inclusion criteria: * body mass index ≤ 25 kg/m2 * physically active individuals * 8 years of school education. exclusion criteria: * high level of anxiety - state-trait anxiety inventory (stai-t) ≥ 35 * high level of anxiety - beck depression inventory ≥ 19 * psqi - pittsburgh sleep quality index ≥ 11 * ess - epworth sleepiness scale ≥ 15 * irregular rhythm of sleep identified by actigraphy * sleep disturbance by polysomnography * shift worker or nocturnal worker; * obesity; * smoker; * alcohol intake of more than 3 drinks per day; * taking sleep medications or illicit drugs.

Keywords: sleep polysomnography reaction time sleep deprivation psychophysiology chronic sleep restriction healthy without sleep complaints
healing outcome of root canal therapy in maxillary molars with dom

Conditions: Periapical Periodontitis

Summary: the aim of study was to evaluate the effect of dental operating microscope use on the healing outcome of non surgical endodontic treatment of maxillary molars.

prior to treatment a thorough clinical and radiological examination was carried out. a thorough history was taken from each patient and written informed consent was taken after explaining the procedure, risks and benefits. mature maxillary first permanent molar with diagnosis of periapical periodontitis (as confirmed clinically \& by periapical radiograph) was chosen for the study. fifty participants were randomly assigned to either the dental operating microscope group or to control group (without using dental operating microscope) for the treatment. after administration of local anesthesia and rubber dam isolation of the involved tooth ; access cavity was prepared using carbide bur and refined using ultrasonic tip in both groups. in both the groups similar protocol for irrigation, obturation and post operative restorations was followed. immediate post-operative radiograph was taken using preset exposure parameters and follow up clinical and radiographic examination was carried at 12th month.

Eligibility criteria:
inclusion criteria: * patient willing to participate in the study * age \> 18 years * maxillary permanent first molar having apical periodontitis requiring primary endodontic treatment * radiographic evidence of periapical radiolucency (minimum size 2 mmx 2 mm) and a diagnosis of pulpal necrosis as confirmed by negative response to cold and electrical tests and absence of bleeding on entering the pulp chamber exclusion criteria: * unwillingness of patient. * retreatment cases * presence of internal or external resorption ,root canal perforations during endodontic treatment and immature teeth. * periodontally compromised teeth * immunocompromised, diabetic, pregnant and hypertensive patients * vertical root fractures * teeth those are not suitable for rubber dam application

Keywords: dental operating microscope
single and multiple dose safety, tolerability, pk and food effect study of hec122505msoh tablets in healthy adult subjects

Conditions: Parkinson Disease

Summary: the safety, tolerability, pharmacokinetic and food effect study of hec122505msoh tablets in healthy subjects


Eligibility criteria:
inclusion criteria: 1. subjects who are willing and are able to provide a written informed consent to participate in the study. 2. without plann for pregnancy or pregnant within 3 months after enrollment throughout the trial. 3. subjects aged between 18 and 45 (both inclusive) years old. 4. healthy volunteers has a body weight ≥50 kg (for male) or ≥ 45kg (for female) and body mass index ≥18 and ≤28 kg/m2 at screening. 5. subjects, who are healthy, as having no clinically significant abnormalities in vital signs, physical examination, clinical laboratory test results, chest x-ray and 12-lead electrocardiogram (ecg). exclusion criteria: 1. subjects with a positive serology for human immunodeficiency virus (hiv) antibodies, hepatitis b surface antigen (hbsag), hepatitis c virus (hcv) antibodies and/or tp antibodies at screening. 2. patients with the following diseases of clinical significance, including but not limited to those with gastrointestinal, kidney, liver, nerve, blood, endocrine, tumor, lung, immune, mental, or cardiovascular and cerebrovascular diseases. 3. nown allergic reactions or hypersensitivity to any excipient of the drug formulation(s)， anaphylaxis physique. 4. use of any prescription or non-prescription medications within 14 days prior to initial dosing，use of any drugs that inhibit or induce liver metabolism within 28 days before the first dose, or use of any of the following drugs within 28 days before the first dose: monoamine oxidase inhibitors, opioids, serotonergic drugs, sympathetic nerves drugs, breast cancer resistance protein substrates, dopaminergic antagonists, etc. 5. consume foods or beverages containing caffeine, xanthine, alcohol, and grapefruit within 48 hours prior to initial dosing. 6. positive results from urine drug screen test. 7. history of alcoholism or drink regularly within 3 months prior to the study (defined as alcohol consumption of \> 21 units/week), or positive results from alcohol breath test. 8. regular smoking of more than 10 cigarettes per day within 3 months before administration of study drug, or inability to refrain from smoking during the course of the study. 9. donate blood or lose blood 400 ml or more within 1 month prior to initial dosing. 10. subjects who plan to receive or have had organ transplants. 11. females who are lactating/breastfeeding, or positive result from pregnancy test for women of child-bearing potential. 12. subjects who participated in another clinical trial within 3 months prior to initial dosing. 13. any other condition with in the opinion of the investigator would render the patient unsuitable for inclusion in the study.
temperament and character traits in young men with idiopathic scoliosis

Conditions: Idiopathic Scoliosis

Summary: this study was designed to investigate whether the temperament and character traits of young men with idiopathic scoliosis differ from healthy individuals of the same age group and characteristics.

all patients who applied to the orthopedics and traumatology department between july 2017 and june 2018 for a medical board examination were evaluated by physical and radiological examination. according to the cobb method, individuals with a cobb angle greater than 10° were diagnosed with idiopathic scoliosis. in the same period, healthy individuals who applied for the same examination and met the inclusion criteria were determined as the control group by random sampling method. all participants were evaluated by a senior psychiatrist. before the interview, all subjects fully informed about the purpose and scope of the study. after their permission was obtained the study and control groups completed a socio-demographic data form consisting of questions about detailed personal and medical history and, the participants were asked to fill in the tci.

Eligibility criteria:
inclusion criteria: inclusion criteria were 18 years of age and older, adequate level of education (at least primary school graduates) and capable of taking the tests and structured interview form, agreed to participate in the study, diagnosed with is and did not have any psychiatric follow-up and treatment history. exclusion criteria: individuals who were younger than 18 years of age, did not accept to participate in the study, had psychiatric disorders according to dsm v diagnostic criteria, additional medical disorders, and who were not at the level of education to take the tests and structured interview form were excluded from the study.

Keywords: idiopathic scoliosis temperament character personality persistence novelty-seeking