Kornimate/medical-research-clean huggingface dataset:
canagliflozin in postprandial hyperinsulinemic hypoglycemia (cana-phh-rygb)

Conditions: Postprandial Hypoglycemia

Summary: roux-en-y gastric bypass (rygb) is the most common surgical procedure for morbid obesity. however, it can present serious late complications, like postprandial hyperinsulinemic hypoglycemia (phh). recent data suggested an increase in intestinal sglt1 after rygb. however, there are no data on the inhibition of slgt1 to prevent phh in patients with prior rybg. objectives: to evaluate in patients that present phh after rygb: a) the effect of canagliflozin 300mg on the response to 100g glucose overload (ogtt); b) the pancreatic response after intra-arterial calcium stimulation. material and methods: prospective pilot study, including patients with phh after rygb, matched by age and gender with healthy controls. basal ogtt and after 2-weeks of daily 300mg of canagliflozin will be performed. in addition, venous sampling after intra-arterial calcium stimulation of the pancreas will be performed.

a prospective opened, placebo uncontrolled, pilot interventional study is performed at the morbid obesity unit of the vall hebron university hospital, including patients that have previously undergone rygb at our site and were diagnosed with phh. the control group comprises of healthy normoweight persons matched by age, most of them family members of patients included in the study. the ogtt is performed as follows: a solution of 100g glucose was administered at 8am after 10 hours of fasting. plasma glucose and serum insulin are measured at minute -5, +30, +60, +120, +180 after the ingestion of the glucose solution. a first ogtt is performed in basal conditions. the control group only will perform the basal ogtt. a value of plasma glucose below 50mg/dl at 60-180 minutes after the administration of the glucose solution is considered positive for phh. the patients that additionally present a value of plasma glucose\>200mg/dl during the ogtt will be selected for continuing in the study and will be prescribed canagliflozin 300mg orally daily, during 2 weeks. after 2 weeks of canagliflozin treatment, a new ogtt will be performed and, in the patients that sign the additional inform consent, the pancreatic catheterism will be realized.

Eligibility criteria:
inclusion criteria: * patients diagnosed with phh following roux-en-y-gastric by-pass, by means of 100g glucose ogtt. plasma glucose \<50mg/dl. * patients that during any time of the ogtt present at least one value of plasma glucose \>200mg/dl, besides hypoglycemia exclusion criteria: * patients unwilling to take canagliflozin 300mg * patients that present with phh following other bariatric surgery techniques
evaluating implant stability using three devices osstell®, periotest® and anycheck®

Conditions: Edentulous Alveolar Ridge

Summary: a prospective observational study guided by the guidelines of strengthening the reporting of observational study in epidemiology (strobe) in 2014, that will be conducted to evaluate implant stability using three devices; osstell®, peiotest® and anycheck® and comparing the results.

in this study, 40 dental implants will be installed in osteotomy sites for patients with single or multiple missing tooth or teeth based on radiographic findings (cbct). the primary stability will be measured immediately after implant installation using three devices : 1. osstell : based on resonance frequency analysis (rfa). 2. periotest: based on damping effect. 3. anycheck: based on tapping motion. secondary stability will be measured after 12 weeks using the same devices mentioned above.

Eligibility criteria:
inclusion criteria: 1. healthy patients over 18 years of either gender, having single or multiple missing teeth in the maxilla and/or mandible. 2. patient with adequate vertical bone height and width for implant placement based on preoperative radiographic findings (cbct). 3. ability to tolerate conventional surgical and restorative procedures. 4. patients who are willing to comply with the study and give their consent. exclusion criteria: 1. active infection or inflammation in the implant zone. 2. presence of any uncontrolled systemic diseases. 3. patients with a history of radiotherapy to the head and neck. 4. any patient requires advanced and complicated surgical techniques such as sinus lift and bone graft.
effect of psychosexual caring program on sexual well-being of infertile women

Conditions: Sexuality; Nursing Caries; Infertility, Female

Summary: the present study aims to examine the effect of the psychosexual caring program on the sexual well-being of infertile women.

the study will be conducted with 70 infertile women. the intervention group (n = 35) will consist of infertile women who receive a psychosexual caring program, and the control group will consist of infertile women who receive standard care. standard care includes the information given by the nurse about the treatment methods to be applied once. a total of 4 interviews will be held in the intervention group. in the first interviews, pre-test data will be taken. the psychosexual caring program will be conducted online as a group intervention. the psychosexual caring program includes interventions to promote body awareness, the meaning of sexuality, and marital relationships by gaining communication skills, sexual communication, body knowledge, information about sexual health, and its dimensions. after online interviews with groups, data will be collected for primary and secondary outcomes.

Eligibility criteria:
inclusion criteria: * having been diagnosed with primary infertility as a result of gynecological evaluation made by experts, * planning an assisted reproductive treatment method for women, * being active in terms of sexual intercourse, * being able to read and write in turkish, * volunteering to participate in the study exclusion criteria: * having any known illness related to sexual dysfunction (diabetes, hypertension, heart disease, kidney failure and autoimmune and rheumatic diseases), * having a psychiatric diagnosis, •not having computer or mobile phone and internet access

Keywords: psychoeducation program infertile women sexual health sexual well-being nursing care
study of trospium chloride inhalation powder (trip) in patients with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: to assess the effect of a single dose of trip on pulmonary function in patients with copd


Eligibility criteria:
inclusion criteria: * male or female copd patients between the ages of 40 and 80 years * smoking history of at least 10 pack years * not currently using (or able to wash out of) any long acting bronchodilators exclusion criteria: * candidate on a waiting list for surgery while on study * using long-term oxygen therapy * hospitalization for copd exacerbation

Keywords: copd
effects of platelet-rich plasma in the surgery of carpal tunnel syndrome: a randomized controlled trial

Conditions: Carpal Tunnel Syndrome

Summary: the platelet-rich plasma (prp) has been proved to be efficient in the non-surgical treatment of carpal tunnel syndrome (cts). here we propose to assess the effectiveness of prp as co-adjuvant in surgical treatment of cts by open carpal tunnel release. design: randomized controlled trial. setting: local hospital.

carpal tunnel syndrome (cts) is a common disorder with an estimated annual incidence of 125-542 in adults, and an estimated prevalence of 1 to 5 percent in the general population. cts is the most frequent compressive focal mononeuropathy and causes pain, paresthesia and weakness of the median nerve distribution in patients. the treatment of the cts includes both, conservative and surgical treatment depending on the severity of the symptoms. platelet-rich plasma (prp) has been proved to be efficient in the non-surgical treatment of cts, however its potential used as co-adjuvant in surgical treatment has not been assessed. we propose a randomized clinical trial in patients in which the surgical treatment is indicated. participants in the intervention group receive a prp injection, and in the control group a platelet-poor plasma injection after open carpal tunnel release. the evaluation is performed pretreatment as well as on the 6st week after treatment. outcome measures include: hand grip strength (primary outcome), pain, sympton severity and functional status.

Eligibility criteria:
inclusion criteria: * patients with carpal tunnel syndrome (cts) * conservative treatment failure exclusion criteria: * previous cts surgery on the same side * wrist fracture/trauma in history * polyneuropathy * diabetes mellitus * cervical neuropathy

Keywords: carpal tunnel syndrome platelet-rich plasma surgery
extrauterine placental transfusion in neonatal resuscitation of very low birth weight infants

Conditions: Very Low Birth Weight Infant; Placental Transfusion; Anemia

Summary: to investigate the effect of extrauterine placental transfusion (ept) compared to delayed cord clamping (dcc) on the mean hematokrit on the first day of life in very low birth weight infants (vlbw) born by caesarian section. the investigators hypothesize that ept provides higher blood volume during neonatal transition and improves neonatal outcome of vlbw infants.

this prospective randomized controlled study will be conducted among 2 groups, all of them are preterm infants with birth weight less than 1500 g ("very low birth weight" (vlbw)) who are delivered by caesarean section, in the first interventional group an extrauterine placental transfusion (ept) will be done during neonatal resuscitation with respiratory pressure support. there will be a delayed cord clamping (dcc) of at least 30 - 60 seconds in the control group, before starting neonatal resuscitation with respiratory support. in ept approach preterm born infants are delivered by caesarean section with the placenta still attached to the infant via the umbilical cord. then, placental transfusion is performed up to several minutes by holding the placenta \~40-50cm above the babies' heart level while respiratory support by mask continuous-positive-airway-pressure (cpap) is initiated simultaneously. extrauterine placental transfusion may give more blood in babies delivered by cesarean section and may improve perfusion during the fetal-to-neonatal transition with impact on neonatal outcome.

Eligibility criteria:
inclusion criteria: * birth weight \< 1500 gram ("very low birth weight infant") * delivery by caesarean section * gestational age \> 23+6 weeks exclusion criteria: * vaginal delivery * fetal or maternal risk (i.e. compromise, emergency c-section) * congenital anomalies and/or major cardiac defects * placental abruption or previa with hemorrhage * placenta accreta or increta * monochorionic multiples (i.e. di/mo or mo/mo twins) * parents declined study

Keywords: extrauterine placental transfusion delayed cord clamping neonatal resuscitation
multidisciplinary approach to reduce injury and substance abuse

Conditions: Drug Abuse

Summary: the primary purpose of the project entitled: multidisciplinary approach to reduce injury and substance abuse, which is funded by the national institute on drug abuse (5r01da026088-02), is to compare the effectiveness of brief intervention, brief intervention plus a booster, and brief advice for adult patients who abuse drugs and present to a trauma department for treatment of an injury.

multidisciplinary approach to reduce injury and substance abuse is a randomized clinical trial evaluating the effectiveness of brief advice (ba), brief motivational intervention with feedback (bmi), and brief motivational intervention with feedback and booster (bmi+b) in injured patients with drug problems. the setting is a level 1 trauma department, which serves a large and diverse patient population. injured patients are screened for eligibility in the project based on a positive toxicology screen or self reported drug use in the past 90 days. the primary outcome of interest will be patients' subsequent drug use. other outcomes of interest include: hiv-related risk behaviors, improved health outcomes (including injury reduction), increased employment, decreased engagement in illegal behavior, increased substance abuse treatment utilization, and enhanced quality of life at three, six, and twelve month follow-ups. this study will also examine the potential moderating and mediating effects of patient readiness to change, use of experiential and behavioral processes of change and decisional balance considerations. in addition, this project will examine implementation factors at the organizational level and the cost effectiveness of ba, bmi, and bmi+b. study participants and their related identifying information will be collected during the time they are admitted to the recruitment hospital trauma department. study participants must be 18 years or older, speak english or spanish, have been admitted to the recruitment hospital trauma department, and test positive for illegal drugs or admit to illegal drug use when verbally screened. additional information will be collected from participants in the in-person assessment interviews at three, six, and 12 month follow-up periods.

Eligibility criteria:
inclusion criteria: * study participants must be 18 years or older * speak english or spanish * been admitted to the level 1 trauma department * test positive for illegal drugs or admit to illegal drug use exclusion criteria: * other penetrating trauma not related to motor vehicle collisions, violence or falls, such as poisoning and, bites * patients with traumatic brain injury, or a glasgow coma scale score of less than 15 * patients who do not pass the mini-mental status exam are excluded

Keywords: drug abuse, injury, trauma, screening, brief intervention.
association between long-term hydroxychloroquine treatment and outcome of a history of symptoms suggestive of covid-19 infection during the epidemic period in france in patients with autoimmune disease

Conditions: SARS-CoV-2; Systemic Lupus Erythematosus; Rheumatoid Arthritis; Sjogren's Syndrome; Psoriatic Arthritis

Summary: this epidemiological, transversal, cohort study aims to determine the potential influence of an active long-term hydroxychloroquine intake over the prevalence of a history of symptoms evocative of a covid-19 infection in patients with a history of systemic lupus erythematosus, rheumatoid arthritis, sjogren's syndrome or psoriatic arthritis, during the epidemic period in france. the information is gathered using a standardized questionnaire, by phone call.


Eligibility criteria:
inclusion criteria: * history of systemic lupus erythematosus, rheumatoid arthritis, sjogren's syndrome or psoriatic arthritis. exclusion criteria: * beginning, or end, of an hydroxychloroquine treatment between jan 1, 2020 and day of the phone call. * bad treatment compliance

Keywords: hydroxychloroquine
prebiotic effect on metabolites in crohn's disease

Conditions: Crohn Disease

Summary: the purpose of this study is to investigate the influence of the prebiotic oligofructose enriched inulin on the metabolite pattern in crohn's disease patients.


Eligibility criteria:
inclusion criteria: * crohn's disease exclusion criteria: * severe crohn's disease (harvey bradshaw index \>12) * pregnancy * history of colectomy * use of antibiotics 4-wks before start of the study * use of sulfapyridine * use of commercially available prebiotics and probiotics
ta-65 and aging associated microvascular dysfunction

Conditions: Telomere Shortening; Aging; Vascular Diseases

Summary: the goal of this clinical trial is to test whether activation of telomerase with a dietary supplement (ta-65) improves microvascular function.

the purpose of this clinical trial is to examine whether activation of autophagy with ta-65 which activates telomerase, improves microvascular function and blood pressure in an older population

Eligibility criteria:
inclusion criteria: * healthy adults 18 - 35 and 65+ years of age * subjects with clinical diagnosis of cad exclusion criteria will include: * 36-64 years of age without clinical diagnosis of cad * self-reported habitual vigorous exercise (\>20 min, 3 times per week, 1 yr) * major adverse cardiovascular event (mace) in the last year (heart attack, stroke) * heart failure * renal impairment * \>3 pre-existing cardiovascular risk factors (healthy groups only) * type 1 or type 2 diabetes * uncontrolled hypertension * current tobacco use or within last 6 months * bmi \> 35 * hyperlipidemia * hypercholesterolemia * use of anti-coagulant drugs * use of anti-platelet drugs * erectile dysfunction medication in the past 6 months * use of topical/non-topical steroids in last 6 months * hormone replacement therapy (post-menopause or gender reassignment) * history of retinopathy * documented neuromuscular disorders * porphyria cutanea tarda (blistering of skin to sun; photosensitivity) * pregnancy (young female subjects) * allergy to lidocaine * current diagnosis of cancer with or without active anti-cancer treatment (pharmaceuticals) or treatment within last 12 months * active covid-19 or within the past 3 months
safety and efficacy of intravenous acetaminophen (iv apap) in adult inpatients

Conditions: Acute Pain; Fever

Summary: the study will be investigating safety and efficacy administration of repeated dose of iv acetaminophen (iv apap) over five days for the treatment of acute pain or fever in adult patients.

• to assess the safety of iv acetaminophen when used over five days for the treatment of acute pain or fever in adult inpatients secondary objectives: * to compare the efficacy of iv acetaminophen 650 milligram (mg) every four (q4) hours vs. 1 gram (g) every 6 (q6) hours over 5 days of treatment * to compare the safety of iv acetaminophen 650 mg q4 hours vs. 1 g q6 hours over 5 days of treatment * to compare the safety of iv acetaminophen vs. standard of care (soc) treatment over 5 days of treatment * to compare the efficacy of iv acetaminophen vs. standard of care treatment over 5 days of treatment

Eligibility criteria:
inclusion criteria: * provide written informed consent prior to participation in the study * be at least 18 years of age and weigh at least 41 kilogram (kg) * be anticipated by the investigator to require multi-day (target is five days) use of iv treatment either because of having a "nothing by mouth" (npo) status having a medical condition that makes oral intake difficult having a medical condition that requires iv treatment * be willing to undergo 5 days of treatment with iv acetaminophen for the treatment of pain or fever (defined as a core temperature greater than or equal to 38 degrees celsius). note that subjects have a slightly less than 15% chance (one in seven) of being assigned to the control group and receiving standard of care treatment, but no iv apap. * have the ability to read and understand the study procedures and have the ability to communicate meaningfully with the study investigator and staff * if a female of child bearing potential, have a negative pregnancy test within 48 hours of randomization exclusion criteria: * has a significant medical disease, laboratory abnormality or condition that, in the investigator's judgment, could compromise the subject's welfare or would otherwise contraindicate study participation * is expected to have difficulty in communicating with the study staff or completing study requirements (including follow up visits) * has known hypersensitivity to acetaminophen or the inactive ingredients (excipients) of iv acetaminophen or any contraindication to receiving acetaminophen * has impaired liver function, e.g., alanine aminotransferase (alt) greater than or equal to 3 times the upper limit of normal (uln), bilirubin greater than or equal to 3 times uln, known active hepatic disease (e.g., hepatitis), evidence of clinically significant chronic liver disease or other condition affecting the liver (e.g., alcoholism as defined by dsm-iv, cirrhosis or chronic hepatitis) * has participated in an interventional clinical study (investigational or marketed product) within 30 days of study entry

Keywords: acute pain fever iv acetaminophen analgesic
influence of type 1 diabetes (t1dm) treatment type on mental workload

Conditions: Type 1 Diabetes; Treatment

Summary: influence of the type of treatment for type 1 diabetes (pump versus multiple injections versus closed loop) on the treatment burden of children and adolescents and their parents.

"the guidelines for the treatment of children and adolescents with type 1 diabetes emphasise an individualised approach to the child and provide target values (time in range, glycaemia and coefficient of variation). these recommendations aim to prevent long-term complications. it is rarely possible to achieve and maintain this level of control over the long term. achieving these recommendations requires a great deal of investment from children and their families, which can significantly increase their psychological workload and reduce their quality of life. the main aim of this study was to assess burden of treatment according to the treatment type (pump versus multiple injections versus closed loop) on a large scale."

Eligibility criteria:
inclusion criteria: * children over the age of 8 whose type 1 diabetes has been diagnosed for at least 6 months * parents or people involved in the day-to-day life of children with type 1 diabetes who have been diagnosed for at least 6 months exclusion criteria: * parents not involved in managing their child's type 1 diabetes (child in care) * have already completed the questionnaire (one questionnaire completed per child and their parents or family caregivers)

Keywords: type 1 diabetes children adolescents parents pump multiple injections closed loop burden of treatment quality of life
exercise regimens and neoadjuvant chemotherapy

Conditions: Cancer of Gastrointestinal Tract

Summary: the purpose of this study is to assess the effectiveness of exercise therapy for patients undergoing neoadjuvant chemotherapy for primary gastrointestinal (gi) tract cancer, providing a reproducible exercise regimen designed to improve or preserve aerobic fitness, strength, and quality of life. in addition, this study will address shifts in healthcare delivery needed as a result of the coronavirus disease 2019 (covid-19) pandemic, evaluating the effectiveness of telehealth instruction as a method for exercise therapy. the study hypotheses are: 1. to evaluate the effectiveness of exercise therapy for cancer patients undergoing neoadjuvant treatment when delivered via telehealth, as compared to an in-person setting. 2. to assess stair test instrumentation, previously validated in a healthy population, as a measure to gauge health status in cancer patients undergoing neoadjuvant treatment. 3. to assess patient satisfaction with exercise therapy when delivered via telehealth, as compared to an in-person setting.

after being informed about the study and potential risks and benefits, all patients meeting inclusion criteria who provide written informed consent will be randomized at the time of enrollment to one of two cohorts engaged in a standardized exercise regimen based on delivery method, either in-person or via telehealth. patient function will be assessed using the timed up and go (tug) test; stairs test; which evaluates aerobic ability, resistance, agility, balance, and posture; and given a score on the karnofsky performance status scale. patient quality of life will be assessed using the functional assessment of cancer therapy - general (fact-g) survey. outcomes for the cohorts will be compared over time.

Eligibility criteria:
inclusion criteria: * 18 to 75 years of age * primary language is either english or spanish * primary cancer diagnosis of gi cancer * undergoing neoadjuvant chemotherapy prior to surgical resection. * patients are being treated by medical oncologist at simmons cancer center at moncrief cancer institute in fort worth exclusion criteria: * patient has had systemic cancer treatment in the past year * patient initiated neoadjuvant chemotherapy treatment prior to study enrollment

Keywords: exercise therapy cancer of gastrointestinal tract neoadjuvant therapies