Kornimate/medical-research-clean huggingface dataset:
phase ii study of alimta (pemetrexed) treatment of advanced thymoma and thymic carcinoma

Conditions: Thymoma; Thymic Carcinoma

Summary: to study the efficacy of alimta as a single agent in thymic cancers

the broad range of clinical activity of thymic carcinomas makes the likelihood of detecting efficacy of a single agent such as premetrexed a reasonable objective since these malignancies are relatively slow growing and exhibit a broad range of chemosensitivity to antineoplastic agents.

Eligibility criteria:
inclusion criteria: * histologically confirmed invasive, recurrent or metastatic thymoma or thymic carcinoma not amenable to potentially curative therapy by surgery. original biopsy of tumor is sufficient for diagnoses unless otherwise clinically indicated. * patients must have measurable disease with at least one bidimensional measurable lesion. any scans or x-rays used to document measurable disease must be obtained with 6 weeks prior to registration. * patients may have had prior chemotherapy for metastatic disease * adequate organ function as defined by: bili \ /=45; hematologic-granulocytes \>/=1500 \& plt \>/=100k. * patients who are receiving a stable dose of corticosteroids for myasthenia gravis are eligible. * ecog performance status of 0 or 1 exclusion criteria: * acute intercurrent infection or complications * pregnancy or lactating patients * inability to interrupt aspirin or other nonsteroidal anti-inflammatory agents for a 5-day period (8-day period for long-acting agents. * presence of clinically relevant third-space fluid collections that cannot be controlled by a procedure

Keywords: thymoma thymic carcinoma
infrared thermal imaging in evaluating the percutaneous transluminal angioplasty for peripheral artery disease

Conditions: Peripheral Artery Disease (PAD)

Summary: determination of irti (infrared thermal imaging) can be used to evaluate pad patients with critical limb ischemia with different degrees of lesion. irti can be used to evaluate the foot blood perfusion after percutaneous transluminal angioplasty (pta) treatment and determine the success rate of surgery. irti can be used as an effective follow-up tool for patients after surgery.


Eligibility criteria:
inclusion criteria: * patients with rutherford grade 3, 4, 5, or 6. * patients with indications for lower extremity arterial pta: severe intermittent claudication, rest pain, ulceration or gangrene. * patients who required pta of only one limb (left versus right). exclusion criteria: * patients with body temperature above 37 ° c. * patients with indications for open surgery. * patients requiring major amputation (above the ankle). * patients with acute occlusive or embolic limb ischemia. * patients with deep venous thrombosis of the lower extremity.

Keywords: peripheral artery disease (pad), infrared thermal imaging (irti), percutaneous transluminal angioplasty (pta)
efficacy and tolerability of abb i5 prebiotic and abb c22 postbiotics for the management of constipation and gastrointestinal well-being: a pilot trial

Conditions: Constipation

Summary: in this study, we aim at assessing the benefits of dietary supplementation with abb i5 and abb c24, a combination of the the prebiotic abb i5 and the postbiotic abb c22, on the gut microbiota of people with constipation and on their gastrointestinal well-being.


Eligibility criteria:
inclusion criteria: * subjects who require hospitalization * constipation defined as the rome iv criteria for constipation * patients with the ability to take the study product orally exclusion criteria: * history of allergy, idiosyncrasy, hypersensitivity or adverse reactions to the active principle or to any of the excipients. * history or evidence of any medical conditions or medication used that, in the opinion of the principal investigator, could affect the safety of the subjects or interfere with the study evaluations * patients last palliative care en stage of "end of life" or "terminal" * amytriptilin (anti-depressive) and masalazine (anti-inflammatory) treatment * laxatives * antibiotic treatment in the previous 2 weeks * patients with ibs or any other gastrointestinal conditions that maybe the cause of the constipation

Keywords: constipation prebiotic postbiotic gastrointestinal dietary supplement
the effect of cryostimulation on inflammation and motor functions. the study was conducted to determine the effect of five days of whole-body cryostimulation (pbc) on reducing inflammation and improving motor skills in soccer players

Conditions: Rest; Training

Summary: the aim of the study was to determine the effect of a 5-day pbc on reducing inflammation and improving motor skills in soccer players during the initial phase of the training period. the five-day cryostimulation applied did not significantly affect the profile of inflammatory markers in soccer players. however, a reduction in visuo-motor reaction time (rt) was registered in pbc-treated soccer players, suggesting the potential benefits of this method in improving motor skills.

cryostimulation is one of the methods of post-exercise recovery, involving short-term (3 min) exposure of the body to extremely low temperatures, oscillating between -100°c and -190°c. the purpose of this therapy is to reduce inflammation, reduce physical and mental fatigue and use it as a passive form of preparing the body for further exercise as part of the training process. the study was conducted to determine the effect of five days of whole-body cryostimulation (pbc) on reducing inflammation and improving motor skills in soccer players. a group of 24 football players was randomly divided into a test group (pbc; -140°c ± 20°c, 3 min, 5 days) and a control group (con). before the cryostimulation session, both groups were subjected to visual-motor ability tests, which were repeated on the last day of the study. blood samples were collected at four time points (p0-1 day, p1-3 day, p2-5 day, p3-2 days after the test). levels of creatine kinase (ck), tumor necrosis factor (tnfα), interleukins (il-6, il-10), testosterone (t) and cortisol (c) were determined in the samples.

Eligibility criteria:
inclusion criteria: * athletes * no previous experience with systemic cryotherapy * any other forms of recovery or cosmetic treatments exclusion criteria: * alcohol or any other stimulants * anti-inflammation drugs * injuries

Keywords: cryostimulation regeneration football players inflammation motor functions
use of ritmonutra in subjects affected by supraventricular ectopic beats without structural heart disease

Conditions: Arrhythmia

Summary: it is a prospective, randomized, double-blinded, crossover study on the use of an association of omega 3 fatty acids, astaxanthin, vitamin e and hawthorn (ritmonutra) in subject affected by symptomatic supraventricular ectopic beats without structural heart disease. the study will evaluate the reduction of the number of supraventricular ectopic beats and symptoms related.

24 subjects without structural heart disease with a minimum of 300 supraventricular ectopic beats in 24 hours will be enrolled in the two participating centers and randomized to the treatment or to the placebo for 4 weeks. at the end of the first treatment period, a 24 hours holter ecg will be performed. after 1 week of wash-out therapy, subjects will be crossed over to the other treatment for 4 weeks. another 24 hours holter ecg will be performed at the end of the study. during the baseline visit and during each follow up visit, symptom score and quality of life questionnaires will be completed by the subjects.

Eligibility criteria:
inclusion criteria: * age: 18 to 80 years * symptomatic supraventricular ectopic beats (at least 300 in 24 hours recording) * no structural heart disease evaluated with ecg, echocardiography, stress test and chest x-ray. * no antiarrhythmic drug in use. exclusion criteria: * acute systemic illness * preexcitation * 3 or more consecutive ectopic beats * vascular disease * diabetes * asthma * soy allergy.

Keywords: supraventricular ectopic beats
dose-response: exercise therapy on hip osteoarthritis

Conditions: Osteoarthritis, Hip

Summary: osteoarthritis is a common disease that causes muscle weakness, stiffness and instability. the disease reduces the opportunities for an active lifestyle. exercise therapy provides a well-documented effect on pain and function in patients with osteoarthritis of the hip. it is sought an optimal dose of exercise, in which this study will help to investigate. we hypothesize that an exercise program designed to have a high number of repetitions will benefit the outcome of the training in a more positive way than a low-repetition based program.


Eligibility criteria:
inclusion criteria: * at least three month since debut of the disease * age above 45 years * ability to complete the intervention exclusion criteria: * pain above 4 on vas during gait * pregnancy * autoimmune disease * cardiovascular disease * respiratory disease * metabolic disease * neurological signs * planned hip-replacement surgery within the next year * received exercise therapy within the last 3 months

Keywords: exercise therapy
analgesic efficacy of saphenous nerve blockade for outpatient knee anterior cruciate ligament surgery

Conditions: Postoperative Analgesia for Anterior Cruciate Ligament Surgery of the Knee

Summary: the purpose of this study is to determine whether blockade of the saphenous nerve can provide the same degree of analgesia postoperatively for acls as a femoral nerve block without resulting motor blockade enhancing shortening of hospital stay en functional outcome.


Eligibility criteria:
inclusion criteria: * age 18-65 years * asa status i - iii * rupture of the anterior cruciate ligament. exclusion criteria: * contraindication for regional anesthesia * allergy against local anesthetics * bmi \> 35 * pre-existing diagnosed neuropathy of the operated leg * ingestion of strong opioids * pregnancy or breastfeeding status * history of significant cardiovascular disease (mi, cva, peripheral vascular disease)

Keywords: saphenous nerve block adductor canal block anterior cruciate ligament pain management day care
the cardiovascular diabetes & ethanol (cascade) trial

Conditions: Diabetes; Prediabetes

Summary: moderate alcohol may be beneficial for diabetics


Eligibility criteria:
inclusion criteria: * established diagnosis of type 2 diabetes * male or female alcohol abstainers (not more than 1 drink/week) * age between 40-75 yrs * clinically stable, with no history of stroke or myocardial infarction or major surgery within the previous 3 months exclusion criteria: * the use of ri or short-acting analog insulin/ pump therapy. patients on 1-2 injections per day of nph or long-acting analogs will be eligible for inclusion * triglycerides \> 500 mg/dl * hba1c\ 10% * serum creatinine \> 2 mg/dl * liver dysfunction (greater than 2-fold elevation of alt or and 3-fold elevation of ast) * evidence of severe diabetes complications (such as proliferative retinopathy or overt nephropathy) * autonomic neuropathy manifested as postural hypotension or hypoglycemia unawareness * patients with chronic hepatitis (c,b) * use of drugs that might significantly interact with alcohol such as sedatives, antihistamines, and anti-coagulants * presence of active cancer, or chemotherapy within the past 3 years * major illness that may require hospitalization * a high potential of addictive behavior based on physician's assessment or personal or family history of addiction, alcoholism, or alcohol abuse * pregnant or lactating woman * participation in another trial with active intervention

Keywords: alcohol diabetes cvd
prophylaxis guided by cytomegalovirus-specific t cell immunity to prevent cytomegalovirus disease in lung transplant recipients

Conditions: Lung Diseases

Summary: the purpose of this study is to evaluate the clinical outcomes of cytomegalovirus (cmv) virus in the participants' body. therefore, the study team will follow the participants' immunological response based on the cytomegalovirus (cmv) virus testing.


Eligibility criteria:
inclusion criteria: 1. adult patients over 18 years of age 2. lung transplant candidates with positive cmv igg 3. anticipated to receive a lung transplant (both double lung and single lung) exclusion criteria: 1. negative cmv igg prior transplant 2. pregnant or breastfeeding women 3. hiv infected patients 4. combined organ (e.g., lung-heart, lung-kidney) transplant candidates
validation of sleep apnea diagnosis device

Conditions: Sleep Apnea

Summary: obstructive sleep apnea (osa) is common and largely underdiagnosed disease. the standard method for the diagnosis of osa is a complete night polysomnography (psg). simple methods for osa diagnosis are necessary. the overnight oximetry with the oxygen desaturation index (odi) has been largely investigated as a diagnostic test for osa but its accuracy remains undefined. the aim of our study is to evaluate if an wireless polygraph (oxistar) is accurate to diagnosis osa in patients referred to a sleep lab.

consecutive patients referred to the sleep laboratory with suspected diagnosis of osa underwent in-laboratory polysomnography (psg) and simultaneously wireless polygraph. the psg oximeter and the wireless polygraph were worn on different fingers of the same hand. all sleep studies were reviewed by one blind investigator according the 2017 american academy of sleep medicine recommendations. the number of desaturations from wireless polygraph at the 3 predefined threshold levels (of odi-2%, odi-3%, or odi-4%) was derived automatically using proprietary algorithm. moderate to severe osa was defined as ahi ≥ 15 events/h. the diagnostic accuracy of odi-2%, 3%, and 4% for the diagnosis of moderate-severe osa were calculated for cut-off values from 1 to 20 desaturation events/h. the sleep actimetry was compared with the sleep stages from psg, most of the statistical metrics applied for diagnosis were used to evaluate the applicability of this proposed method. finally, the snoring events computed by the smartphone application were compared with the events heard by a specialist and the statistical comparison metrics were evaluated.

Eligibility criteria:
inclusion criteria: * referred by medical staff for an overnight assessment for suspected sleep apnea exclusion criteria: * polysomnography for the cpap titration

Keywords: sleep apnea polygraph home sleep apnea test (hsat) apnea hypopnea index (ahi) oxygen desaturation index (odi) portable monitor sleep actimetry snoring
extrapleural intercostal catheter vs. thoracic epidural for thoracotomy pain

Conditions: THoracotomy

Summary: we will compare thoracic epidural anesthesia which is presently used for management of pain after thoracotomy to an intra-operatively placed extrapleural intercostal catheter. the study wil be double blinded and prospective.

the aim of this study is to evaluate the efficacy of thoracic epidural vs. continuous extra-pleural intercostal local anesthesia for the treatment of post thoracotomy pain in adult patients. study patients will be randomized between the thoracic epidural and continuous extrapleural catheter groups\[figure 1\]. because thoracic epidural anesthesia is the gold standard but continuous extrapleural intercostal local anesthesia is potentially easier and less prone to complications, the study will be structured as an "equivalence study". the null hypothesis (ho) is that continuous intercostal nerve blockade is worse than epidural for post-thoracotomy pain management. therefore, the alternative hypothesis (ha) is then that continuous intercostal nerve blockade is equal to or better than epidural for post-thoracotomy pain management.

Eligibility criteria:
inclusion criteria: * unilateral thoracotomy * video assisted thoracotomy with high likely hood of converting to open thoracotmoy exclusion criteria: * bilateral thoracotomy * planned bilateral thoracotomy * planned chest wall resection * planned combined thoracotomy and laparotomy procedure * vats procedure without conversion to unilateral thoracotomy * emergency operation * critically ill patients * patients who require an assistive device (i.e. cane, walker, or wheel chair) for mobility * patients who are unable to give informed consent * patients with preoperative chronic back or chest wall pain * empyema or other infective condition increasing the risk of epidural infection * coagulopathy * decision of the surgeon or anesthesiologist, or choice of the patient * infection at site of epidural placement * patients with other co morbidities which exclude thoracic epidural placement * patients under the age of 18 years

Keywords: thoracic surgery thoracic epidural epidural thoracotomy intercostal nerve block intercostal nerve block
obstructive sleep apnoea and adipose tissue dysfunction

Conditions: Obstructive Sleep Apnoea; Obesity; Hypoxia

Summary: dysfunctional adipose tissue predisposes to cardiovascular disease. similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. the investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo at oxygenation and blood flow in tissue of control subjects.

assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a clarke type electrodes and non-invasive doppler techniques.

Eligibility criteria:
inclusion criteria: * men with or without obstructive sleep apnoea exclusion criteria: * weight loss interventions * steroid use * active smoking

Keywords: obesity hypoxia adipose tissue
response to influenza vaccine in patients with non-hematologic malignancies receiving chemotherapy

Conditions: Neoplasms

Summary: this clinical trial studies the best time to administer the influenza vaccine to patients with non-hematologic malignancies receiving chemotherapy. giving the vaccine at different times relative to chemotherapy may affect how well it works to help the body build an immune response and prevent influenza in these patients.


Eligibility criteria:
inclusion criteria: * patients must have biopsy-confirmed non-hematological malignancy * patients must be scheduled to receive cytotoxic chemotherapy (adjuvant or metastatic setting), excluding immunotherapy * patients must be of age \>=18 years. * patients must have an absolute lymphocyte count \>= 1,000/mcl immediately prior to influenza vaccination * ability of the patient (or legally authorized representative if applicable) to understand and the willingness to sign a written informed consent document exclusion criteria: * patients who have already received the influenza vaccine during the season in which they are considered for eligibility will be excluded * history of allergic reactions attributed to compounds of similar chemical or biologic composition to the influenza vaccine or egg allergies * previous history of guillian-barre syndrome within the previous 6 weeks to influenza vaccination * patients must not be receiving chronic steroid therapy, defined as \>= 14 days, unless used as part of a chemotherapy regimen * patients must not be on any other agents that can suppress the immune system * planned concurrent therapy with radiation * uncontrolled illness at time of enrollment or influenza vaccination including, but not limited to, ongoing or active febrile illness * psychiatric illness/social situations that would limit compliance with study requirements * known immunosuppression eg. history of organ transplantation or known human immunodeficiency virus (hiv)-positive patients on combination antiretroviral therapy are ineligible because they may not be able to mount an appropriate immune response * history of influenza-like illness, defined as a temperature \> 37.8 degree c with cough or sore throat starting october 1, 2011 throughout the duration of the study * patient may not be scheduled to receive chemotherapy on a weekly basis.
qualitative analysis on the experiences of employment among schizophrenic patients

Conditions: Schizophrenia

Summary: the aim of this search is to realize the subjective experiences of employment among schizophrenic patients by qualitative analysis. we plan to recruit 50 people diagnosed with schizophrenia and divide into two groups, employment and unemployment. every subjects will complete the demographic data, the evaluation of severity of disease, the record of medication and an intensive interview about their employment experiences. finally, we will analysis the thick descriptions to understand how schizophrenic patients interpret their employment experiences and which factors will affect their successful employment.


Eligibility criteria:
inclusion criteria: * schizophrenia * \> high school
bihemispheric transcranial direct current stimulation* on speech fluency

Conditions: Stuttering, Adult

Summary: it will be determined whether bihemispheric stimulation (anodal to the left ifg and cathodal to the right ifg) is used with fluency-facilitating conditions for 5 consecutive days in individuals with stuttering and whether there is a difference in terms of the effects seen in speech fluency compared to the sham condition.

developmental stuttering is a fluency disorder that can negatively affect many aspects of an individual's life. recent transcranial direct current stimulation (tdcs) studies with individuals with stuttering show that tdcs shows promise in increasing fluency when used in combination with situations that temporarily increase fluency. in this study, it was aimed to investigate the effect of bi-hemispheric tdcs on fluency in individuals with stuttering for 5 consecutive days. the hypothesis of the study is that bi-hemispheric stimulation, which includes anodal stimulation to the left hemisphere and cathodal stimulation to the right hemisphere, will be effective on reading and speech fluency when performed for 5 consecutive days. thirty-six adults with developmental stuttering are expected to complete this double-blind, sham-controlled study. participants will be divided into two groups by blocked randomization and one group will receive sham stimulation for 5 consecutive days and the other group will receive bihemispheric stimulation. participants in the tdcs group will receive 20 minutes of tdcs stimulation accompanied by metronome-timed speech during the practice sessions. reading and speaking fluency will be assessed immediately before, immediately after, and one week after the stimulation sessions. data will be collected using the stuttering severity assessment instrument (ssi-4) results will be compared both within and between groups in terms of percentage of stuttered syllables, stuttering severity, and evaluation of the speaker's experience of stuttering.

Eligibility criteria:
inclusion criteria: * developmental stuttering * age between 18 and 60 years * right hand dominant exclusion criteria: * history of seizures, head trauma, hearing problems, cochlear implant, intracranial metal implantation, medications that affects the central nervous system, implanted neurostimulators, cardiac pacemakers, or medication infusion devices * any speech and language disorder other than developmental stuttering * neurological or psychiatric disorders, brain surgery, tumours, neurodevelopmental disorders, or attention deficit hyperactivity disorder

Keywords: stuttering tdcs non-invasive brain stimulation speech therapy