Kornimate/medical-research-clean huggingface dataset:
two dimensional (2d) silicon transducer-compression plates for breast ultrasound

Conditions: Breast Tumor; Breast Cysts

Summary: the study purpose is to help in the developement of 3 dimensional breast ultrasound imaging.

to assist in the developement of 3 dimensional breast ultrasound imaging and when possible compare the ultrasound results with 3d mammography (digital tomosynthesis mammography)or clinical mammography and ultrasound. hopefully that this new, 3d ultrasound imaging can provide important information not found on mammograms or routine breast ultrasound.

Eligibility criteria:
inclusion criteria: * healthy women or * women with suspected benign masses who may/or may not be going to biopsy * women with cysts where no biopsy is recommended exclusion criteria: * women who are pregnant * women with breast implants * prisoners
prophylactic mesh reinforcement after open aortic aneurysm repair

Conditions: Incisional Hernia; Aortic Aneurysm

Summary: the goal of this retrospective observational study is to evaluate whether prophylactic mesh reinforcement during abdominal wall closure can prevent incisional hernias (ih) in patients undergoing open abdominal aortic aneurysm (aaa) repair. the main questions it aims to answer are: * does mesh reinforcement reduce the incidence of incisional hernias? * what is the frequency of associated postoperative complications? researchers will compare the outcomes of patients who underwent mesh-reinforced closures to literature-reported outcomes for non-mesh cases to assess differences in ih incidence and complications. participants will: * undergo clinical follow-ups and abdominal ultrasounds to detect ih. * complete quality-of-life questionnaires (eq-5d and promis).


Eligibility criteria:
inclusion criteria: * adult patients (≥18 years old) who underwent open abdominal aortic aneurysm (aaa) repair with prophylactic retromuscular mesh reinforcement between january 2019 and january 2024 * availability of complete medical records, including preoperative history, surgical details, and postoperative follow-up data * attendance at a clinical follow-up examination at least one year after the procedure * general informed consent signed for the use of medical data for research purposes exclusion criteria: * patients with incomplete or missing medical records, including preoperative, intraoperative, or follow-up data * patients who required a re-laparotomy involving incision or suture of the prophylactic mesh and subsequently developed an incisional hernia. * patients who did not attend the required clinical follow-up examination at least one year postoperatively.
influence of an endometrioma on oocyte quality

Conditions: Endometriosis

Summary: the purpose of this study is to evaluate if there are differences in oocyte quality depending on whether these oocytes come from an ovary in contact with an endometrioma.

there is no consensus for whether an endometrioma influences oocyte quality, as well as the possible mechanisms that induce them. in this study, the oocyte maturation will proof oocyte quality: this mean, the percentage of oocytes in metaphase ii obtained after stimulation, as well as the rate of oocytes fertilized in direct contact with an endometrioma.

Eligibility criteria:
inclusion criteria: * patients \<40 years, bmi \<30kg / m2, exclusion criteria: -
mri parenchymal enhancement: a new marker of breast cancer risk

Conditions: Cancer Free Women

Summary: the purpose of this study is to learn about how a woman's health history influences what a normal breast looks like on an mri. the investigators also want to learn about how the amount of different natural hormones a woman has affects how the breast looks on an mri. the investigator's hope is that this will help to find women at a high-risk of breast cancer.


Eligibility criteria:
inclusion criteria: * age 21 years or older * be a cancer-free pre- or postmenopausal woman * have no prior personal history of any cancer (including dcis, excluding nonmelanoma skin-cancer) * able to speak and read english because the questionnaire is only available in english * able to provide informed consent exclusion criteria: * are pregnant at the time of mri * have a prior personal history of any cancer (including dcis, excluding nonmelanoma skin cancer)

Keywords: mri 12-125 premenopausal women postmenopausal women questionnaire
exploration of key targets and biomarkers involved in an allergic response in subjects with allergic rhinitis (hay fever)

Conditions: Allergic Rhinitis

Summary: this study is aimed at validating key therapeutic targets and biomarkers associated with allergic rhinitis. the therapeutic target expression will be investigated after a 7 day course of corticosteroid treatment followed by allergen challenge.


Eligibility criteria:
inclusion criteria: * no signs or symptoms of rhinitis outside of the relevant airborne allergen season. exclusion criteria: * history or current evidence of an upper or lower respiratory infection or symptoms (including common cold) within 2 weeks of baseline assessments. * symptoms of rhinitis at inclusion indicated by total vas score of \>40 for the combined symptoms scores for blockage, rhinorrhoea, sneezing, itching) or a single symptom with a vas score \>20. * subjects not showing a nasal response to allergen concentration =\< 10,000 bu/ml. * subjects with positive skin prick test for dust house mite.

Keywords: hay fever biomarkers
using the drug spironolactone to test if it reduces protein leakage from the kidney

Conditions: Kidney Disease; Diabetic Nephropathy; Glomerulonephritis; Proteinuria

Summary: the purpose of this study is to determine which combination of the tablets ramipril, irbesartan or spironolactone is best to lower protein leakage from the kidney.

protein leak from the kidney into the urine is an indicator of kidney damage. the higher the leak, the worse the damage and the more likely the patient will lose their kidney function long term. interventions that lower protein leak make the kidneys last longer. there are 2 groups of medications, both blood pressure tablets, the acei (angiotensin converting enzyme inhibitors) and atrb (angiotensin receptor blockers) which have shown to reduce the amount of protein leaking from the kidney and as a result lengthen the life of the kidney. there has also been evidence that using these 2 tablets in combination is better than using either one alone. in spite of these tablets, there still remain some patients that continue to leak protein in the urine. recently there has been evidence that the tablet spironolactone, which is a fluid tablet, also reduces protein leakage from the kidney. in this study we look at various combinations of these tablets to see which works best to lower protein leakage from the kidney. patients are divided into 4 groups. each group will receive the tablet ramipril (an acei). in group 1, patients will be on ramipril and 2 blank tablets, group 2 will be on ramipril, irbesartan (an atrb) and a blank tablet, group 3 will be on ramipril, spironolactone and a blank tablet and group 4 will be on ramipril, irbesartan and spironolactone. protein leakage is measured at the beginning and after 3 months of treatment.

Eligibility criteria:
inclusion criteria: * proteinuria more than 1.5 g/day * on acei for more than 6 months * serum creatinine less than 200 micromol/l with less than 20% variability in the preceeding 3 months * creatinine clearance more than 30 ml/min, with less than 20% variability in the preceeding 3 months exclusion criteria: * serum potassium level more than 5 mmol/l * treatment with corticosteroids, nsaid or immunosuppressant medication * acute myocardial infarction or cerebrovascular accident in the previous 6 months * severe uncontrolled hypertension (diastolic \> 115 mmhg or systolic bp \[blood pressure\] \> 220 mmhg) * evidence or suspicion of renovascular disease, obstructive uropathy, collagen disease, cancer, drug or alcohol abuse, pregnancy, or breast feeding and ineffective contraception

Keywords: spironolactone proteinuria angiotensin converting enzyme inhibitor angiotensin receptor blocker renin angiotensin aldosterone system aldosterone
efficacy and safety of aczone 7.5% gel in the treatment of truncal acne vulgaris

Conditions: Acne

Summary: to determine if dapsone (aczone) 7.5% gel is a safe and effective treatment for acne on the trunk

this is an open label pilot study to determine the safety and efficacy of dapsone (aczone) 7.5% gel applied daily to the trunk for acne. subjects will apply dapsone for 16 weeks.

Eligibility criteria:
inclusion criteria: * male and female subjects of any race and at least 12 years of age. * female subjects of childbearing potential must have a negative urine pregnancy test at baseline and practice a reliable method of contraception throughout the study. * truncal acne iga score of 3. * able to understand the requirements of study and sign informed consent/hipaa forms. exclusion criteria: * female subjects who are pregnant , breast feeding or are of childbearing potential who are not willing to use a reliable method birth control. * subjects who have an allergy or sensitivity to any component of the test medication. * subjects who have not complied with the proper wash out periods for prohibited medications. * evidence of recent drug or alcohol abuse. * skin disease /disorder that might interfere with the diagnosis or evaluation of truncal acne. * exposure to an investigational drug within 30 days of the baseline visit. * medical condition that contraindicates the subject's participation in the study. * history of poor cooperation, non-compliance with medical treatment or unreliability.
parasternal nerve block using bupivacaine for postoperative analgesia in children undergoing cardiac surgery

Conditions: Pain

Summary: all pediatric patients who undergo cardiac surgery require analgesic medications for postoperative pain control and many require sedation to facilitate comfort with cares. parasternal infiltration of local anesthetic for nerve blocks is a simple option to postoperative analgesia. the investigators hypothesize that bupivacaine, a parasternal nerve block administered in pediatric patients undergoing cardiac surgery will reduce the requirement of opioids and other pain medications as well as decrease postoperative pain scores. this is a prospective, double-blind, randomized controlled trial. subjects are randomized to receive either 0.25% bupivacaine or normal saline following their cardiothoracic surgery.

one of the most challenging struggles in clinical practices in pediatric cardiac intensive care units is the provision of optimal and safe postoperative analgesia and sedation. all pediatric patients who undergo cardiac surgery require analgesic medications for postoperative pain control and many require sedation to facilitate comfort with cares. parasternal infiltration of local anesthetic for nerve blocks is a simple option to postoperative analgesia. bupivacaine is a local anesthetic that can be injected into the intercostal spaces on each side of a sternotomy to induce nerve block. the purpose of this study is to evaluate whether the use of bupivacaine as a nerve block in children undergoing cardiothoracic surgery will reduce postoperative pain medication use and decrease postoperative pain scores. the investigators hypothesize that the administration of bupivacaine bilaterally into the posterior intercostal spaces on each side of a sternotomy following cardiothoracic surgery will reduce the requirement of pain medications as well as decrease postoperative pain scores. this is a prospective, randomized, double-blind, control study. subjects are randomized into two arms: those who receive 0.25% bupivacaine and those who receive placebo (normal saline). subjects receive 1 milliliter per kilogram up to 20 kilograms, then 0.5 milliliters per kilogram up to 50 kilograms of study drug. subjects are followed for 5 days postoperatively, then on day of discharge. pain medication administered and face, legs, activity, cry, and consolability (flacc) scores are recorded daily for 5 days.

Eligibility criteria:
inclusion criteria: * age 0-17 years old at time of surgery * society of thoracic surgeons- european association for cardio-thoracic surgery (stat) mortality categories 1-3 * surgical intervention requiring median sternotomy * expected extubation within 24 hours of surgery exclusion criteria: * known allergic reaction or hypersensitivity to bupivacaine or to any local anesthetic agent of the amide type * delayed sternum closure

Keywords: bupivacaine cardiac surgery pediatrics nerve block
dasatinib for patients achieving complete molecular response for cure d-news trial

Conditions: Myelogenous Leukemia, Chronic, Chronic Phase

Summary: the purpose of this study is to assess whether dasatinib can be discontinued without occurrence of molecular relapse in patients with chronic myeloid leukemia in chronic phase in complete molecular remission(cmr) while on dasatinib.


Eligibility criteria:
inclusion criteria: * newly diagnosed chronic myeloid leukemia in the chronic phase * 15 years old over. * ecog performance status (ps) score 0-2. * adequate organ function (hepatic, renal and lung). * signed written informed consent. exclusion criteria: * a case with the double cancer of the activity. * women who are pregnant or breastfeeding. * female patient who there is not intention with an appropriate sterilization, or cannot use it during a study entry period * patients with complications or a history of severe or uncontrolled cardiovascular failure following have a myocardial infarction within 6 months have an angina within 3 months have a congestive heart failure within 3 months have a qtc interval of more than 450msec at baseline * a serious uncontrolled medical disorder that would impair the ability of the subjects to receive protocol therapy
plastic vs biodegradable pancreatic stent in post-ercp pancreatitis prevention

Conditions: Biliary Tract Diseases

Summary: multiple risk factors have been linked with post-endoscopic retrograde cholangiopancreatography pancreatitis (pep); therefore, it is critical to follow strategies to reduce associated risk, morbidity, and mortality. however, there are also factors, such as pancreatic duct stenting, which have shown evidence of pep prevention. the investigators pursue to compare plastic vs biodegradable pancreatic stents in the prevention of pep.

endoscopic retrograde cholangiopancreatography (ercp) is a high-skilled endoscopic procedure, which is currently mainly used as a therapeutic mean for various pancreaticobiliary disorders. its most common serious adverse event is pep. multiple risk factors have been linked with pep (patient/procedure/operator-related). therefore, it is critical to follow strategies to reduce associated risk, morbidity, and mortality. a recent metanalysis reported an overall incidence of pep close to 10%, with an even higher incidence (14.7%) in high-risk patients. pep's risk factors work synergically and have exhibited up to a 40% incidence rate in multifactorial patients. however, there are also factors, such as pancreatic duct stenting, which have shown evidence of pep prevention. the prophylactic use of pancreatic duct stents (especially 5 fr stents) has exhibited a statistically significant pep severity and incidence reduction; particularly for high-risk patients, for those who have undergone inadvertent repeated pancreatic duct cannulation or those in whom it is difficult to perform biliary cannulation. controversially, failed pancreatic duct placement has shown a 34.7% pep incidence rate and is considered an independent risk factor for pep. in the case of stent migration, stent-induced perforation may arise regardless of the type of stent used (plastic or metallic), but if no signs of peritonitis are displayed, the endoscopic approach may suffice for stent removal and tracks closure. rarely the surgical approach is guaranteed for migrated stents in the presence of peritonitis or retroperitoneal fluid collection. the investigators pursue to compare plastic vs biodegradable pancreatic stents in the prevention of pep.

Eligibility criteria:
inclusion criteria: * patient is scheduled for ercp * patient is 18 years old or older * biliary tract disease presence * non-manipulated pancreatic papilla * written informed consent provided exclusion criteria: * patient not requiring pancreatic stenting during ercp * failed pancreatic stent placement * patients at risk of fluid overload * patients with cholangitis, sepsis, acute/flared up chronic pancreatitis * recent previous biliary tract manipulation (i.e., pancreatoscopy, wirsungoscopy, etc.) * hemodynamic instability * uncontrolled coagulopathy, kidney/liver failure, or any comorbidity with a meaningful impact on cardiac risk assessment (nhya iii/iv) * pregnancy or nursing * refuse to participate in the study or to sign corresponding informed consent

Keywords: biliary tract diseases pancreatic duct stents
daily aspirin treatment after preeclampsia

Conditions: Preeclampsia

Summary: women who develop preeclampsia during pregnancy are four times more likely to develop cardiovascular disease later in life, even if they are otherwise healthy. the reason why this occurs may be related to lasting blood vessel damage after the pregnancy but there are currently no specific treatment strategies to prevent this disease progression. this study addresses this public health issue by examining whether starting low dose aspirin therapy after pregnancy is an effective treatment for lasting blood vessel damage in order to inform better clinical management of cardiovascular disease risk in women who have had preeclampsia.


Eligibility criteria:
inclusion criteria: * had preeclampsia in the past 5 years, * 18 years or older exclusion criteria: * current daily aspirin use, * skin diseases, * current tobacco or nicotine use (including vaping), * diagnosed or suspected hepatic or metabolic disease including chronic kidney disease (ckd) defined as reduced egfr \< 60 ml/min/1.73m2, * statin or other cholesterol-lowering medication, * current antihypertensive medication, * history of hypertension prior to pregnancy, * history of gestational diabetes, * currently pregnancy, * body mass index \<18.5 kg/m2, * allergy to materials used during the experiment.(e.g. latex), * known allergies to study drugs, * bleeding disorders, peptic ulcer disease, gastritis, gi bleeding and gastroesophageal reflux disease (gerd).

Keywords: preeclampsia
prospective observational study on the analgesic effectiveness of blocking the suprascapular and axillary nerves in shoulder arthroscopy.

Conditions: Analgesia; Shoulder Arthropathy Associated With Other Conditions; Suprascapular and Axillary Nerve Block

Summary: the purpose of this study was to evaluate the analgesic efficacy of suprascapular and axillary nerve block for shoulder arthroscopy surgery

an observational study of paired cohorts, not randomized, was designed with the aim of comparing the postoperative analgesic effectiveness of two regional analgesic techniques: the shoulder anterior capsular block associated with the suprascapular nerve block performed via an anterior approach versus the suprascapular and axillary nerve blocks performed posteriorly in patients with shoulder surgery via arthroscopy in procedures that cause intense postoperative pain.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age. * asa (physical status classification system) i - iii. * having been scheduled for shoulder arthroscopy surgery. exclusion criteria: any contraindication for performing regional anesthetic techniques: * infection at the puncture point. * alteration of hemostasis. * allergy to local anesthetics. * patient refusal to participate in the study. * inability to evaluate postoperative pain. * known neuropathy of the operated limb. * patients who required conversion to open surgery.

Keywords: shoulder arthroscopy suprascapular nerve axillary nerve multimodal analgesic strategies
inuline supplement in patients with irritable bowel syndrome

Conditions: Irritable Bowel Syndrome

Summary: the study investigate the efficacy of the combination inuline, choline and silymarin in alleviating the symptomatology of the patients with irritable bowel syndrome with constipation in a randomized, cross-over, no treatment controlled study.

in this study patients diagnosed using rome iv criteria with irritable bowel syndrome with constipation are included. the study was approved by the ethic committee of the university of medicine and pharmacy "gr. t popa" iasi to be conducted at the institute of gastroenterology and hepatology of clinical emergency hospital "sf. spiridon" iasi. the patients are assigned after a randomized scheme to one of the groups: diet restriction scheme or diet restriction scheme plus a product with inuline, choline and silymarin. after 28 days the patients are crossed between the groups and followed for additional 28 days diet scheme with or without inuline, choline and silymarin supplementation. all the patients are evaluated initially, in the day 28 and in the day 57 for the stool habits, stool characteristics using brystol scale and symptoms severity (abdominal pain, frequency of abdominal pain, bloating severity, patients satisfaction in relation with stool frequency and the impact of ibs on daily activity) as appreciated by the patients for the last 10 days. the acquired data will be analyzed and published.

Eligibility criteria:
inclusion criteria: * patients aged 18-75 years, diagnosed with irritable bowel syndrome using roma iv criteria exclusion criteria: * patients with ibs with predominant diarrhea or mixt symptoms * patients with known hypersensitivity to any of the ingredients of the dietary supplement * patients who used prebiotic, probiotic or laxative products in the last 10 days * pregnancy and lactation
thermotherapy in acute nonspecific neck pain

Conditions: Neck Pain; Cold

Summary: neck pain is one of the most common musculoskeletal pain disorders secondary to low back pain. medical and non-medical treatments such as physiotherapy are applied in its treatment. patients with nonspecific neck pain (nba) can be treated with various interventions such as drug therapy, manual therapy, heat and exercise. although it is frequently used in clinical practice, there is no evidence that superficial thermotherapy (hot or cold) methods effectively relieve neck pain. therefore, this study aims to compare the short-term effects of superficial hot or cold applications on pain, range of motion and functional status in patients with nba.


Eligibility criteria:
inclusion criteria: * being diagnosed with nonspecific neck pain by a doctor, * to be between the ages of 18-65, * neck pain lasting for less than 1 month * no previous neck or shoulder surgery, * no shoulder pain due to any cause, * a tumour or inflammatory disease underlying the neck pain not to be found, * a clinically underlying stenosis or discogenic problem not to be present. * negative results from the following clinical examination tests; spurling test, lhermitte test, cervical distraction test, adson test, exclusion criteria: * not meeting the inclusion criteria, * positive neurological examination (positive motor presence, reflex or sensory abnormalities indicating spinal root compression) or abnormal neurological findings related to nerve compression in the upper limb * systemic rheumatological or metabolic diseases or cancer * refusal to participate in the study, * failure to complete treatment, * having any neurological problem * severe psychological illnesses