Kornimate/medical-research-clean huggingface dataset:
innovative mri to localize the epileptic zone

Conditions: Epilepsy, Temporal Lobe

Summary: the goal of epi-catcher is to outline the clinical potential of multiparametric quantitative mri (mqmri) and of gaba-edited magnetic resonance spectroscopy (gaba-mrs), combined with machine learning tools, as imaging biomarkers to localize and delineate the ez.

after informed consent, patient candidate to resection surgery will undergo two extra mri sessions before surgery: one for multiparametric quantitative mri (mqmri) and one for gaba-edited magnetic resonance spectroscopy (gaba-mrs) in parallel, a group of healthy volunteers will also undergo the two mri sessions described above, to collect reference data.

Eligibility criteria:
inclusion criteria: * patient group * patients aged 18-65 years, * patients with drug-resistant focal epilepsy, * patients with mtle suspicion, with normal mri or hippocampal sclerosis, and candidate for surgery, * negative pregnancy test for child-bearing aged woman, * obtained signed informed consent from patient * reference group * male or female, 18-65 years, * obtained signed informed consent from participants, * negative pregnancy test for child-bearing aged woman exclusion criteria: * patient group * patient without social security system * inability or unwillingness of the individual to provide written informed consent, according to national regulations. * impossibility of collecting information on exposure (subjects recently arrived in france, foreign language, etc.), * contraindication for mri, * contraindication for injection of mri contrast agent (gd-chelate), * evidence on neuroimaging (ct or mri) of a brain lesion in the same hemisphere as the ez (tumor, stroke, cerebral edema with midline shift and a clinically significant compression of ventricles, or subarachnoid hemorrhage, or intracerebral parenchymal hematoma (petechial small hemorrhages are not a non-inclusion criteria), * severe leucoariosis * pre-existing dementia * pregnant, breastfeeding women * reference group * person who is participating in another therapeutic trial * person with a psychiatric disorder, an epilepsy, or a brain lesion susceptible to impact the mri readouts * person without social security system, * inability or unwillingness of the individual to provide written informed consent, according to national regulations, * impossibility of collecting information on exposure (subjects recently arrived in france, foreign language, etc.), * contraindication for mri * contraindication for injection of mri contrast agent (gd-chelate) * pregnant, breastfeeding woman.

Keywords: mri quantitative gaba mrs
breast cancer treatment based on organ-like culture

Conditions: Breast Cancer Organoids

Summary: based on the breast cancer organ platform, this experiment establishes a drug sensitivity test method that is closer to the body tumor in breast cancer, provides a basis for the accurate treatment of breast cancer, and discusses the possible mechanism of breast cancer drug resistance.


Eligibility criteria:
inclusion criteria: patients with breast cancer and the largest tumor diameter ≥ 3cm no previous chemotherapy regimen age 18-65 years old can obtain the tumor tissue specimens required for culture heart, liver, kidney and bone marrow hematopoietic function is good know and sign the informed consent form exclusion criteria: pregnant or lactating women also suffering from other cancer patients there are serious uncontrolled medical diseases or acute infections those who are known to be allergic to this study drug or a variety of previous drugs the patient cannot understand the purpose of the study or disagree with the requirements of the study. other investigators believe that patients who are not suitable for this study group

Keywords: drug sensitivity experiment resistance mechanism research
study assessing hybrid spect-ct with labeled leukocytes for diagnosis of vascular prosthesis infections

Conditions: Vascular Prosthesis Infection

Summary: vascular prothesis infection is a rare but an extremely serious complication. diagnosis is often difficult (germs are found only in 50% of cases). conventional imagery is often non-specific and difficult to interpret especially in early postoperative phase. leukocytes isolated from the patient's blood are labeled with a radiopharmaceutical technetium 99mtc-hmpao. the aim of this study is to assess the overall diagnostic performance of scintigraphy (hybrid spec-ct) with labeled leucocytes in diagnosis of subdiaphragmatic vascular prothesis infection.


Eligibility criteria:
inclusion criteria: * patient of more than 18 years old * patient with a subdiaphragmatic vascular prosthesis * vascular prosthesis infection suspected with clinical (flow from the scare and/or local pain and/or erythema and/or persistent fever and/or bacteraemia) and/or biological (inflammatory syndrome : elevated c-reactive protein and/or erythrocyte sedimentation rate (esr) and/or white blood cells increased) infection signs * patient willing to participate with a signed informed consent * patient covered by a healthcare insurance exclusion criteria: * pregnant women or of childbearing age without effective contraception * prosthesis limited to a bare stent. * patient who has been committed to an institution by legal or regulatory order * contraindications for labeled leukocytes scintigraphy realization : * restlessness, inability to keep still lie at least 1 hour * claustrophobia * poor compliance predictable or impaired general condition making it impossible to carry out the examination * refusal to participate in the study

Keywords: 99mtc-exametazime (hmpao)-labeled leukocytes suspected subdiaphragmatic vascular prosthesis infection diagnosis
ablating atrial tachycardias occuring during ablation of complex fractionated electrograms in persistent af

Conditions: Atrial Fibrillation; Ablation; Atrial Flutter

Summary: catheter ablation has proven to be an effective treatment option in patients suffering from symptomatic persistent atrial fibrillation (af). catheter ablation consists of two major steps: (1) isolation of pulmonary veins to abolish the trigger of atrial fibrillation and (2) modification of left atrial and eventually right atrial substrate by ablation of complex fractionated atrial electrograms (cfae). cfae are mainly found at the ostia of the pulmonary veins, around the left atrial appendage, at the mitral annulus and the septum. when ablating cfae 40-65% of the patients show a regularization of af to an atrial tachycardia (at) that can be macro- or micro-reentrant (localized re-entry). until now the significance of the at is unclear. in the following study we examine the hypothesis that an ablation of at occuring during cfae ablation (group 1) significantly improves outcome defined as freedom of atrial arrhythmia (af or at) compared to patients that are cardioverted when af has regularized to at (group 2).


Eligibility criteria:
inclusion criteria: * patients (\>=18 und \< 80 years) with symptomatic persistent af (af episode enduring at least 7 days) but are successfully convertable in sinus rhythm (sr). * at least one unsuccessful attempt of antiarrhythmic drug (betablocker or class i oder iii). * oral anticoagulation with phenprocoumone or warfarine for at least 4 weeks prior to ablation with weekly documented inr \> 2.. * withdrawal of antiarrhythmic drugs at least 3 half times prior to ablation except amiodarone. * atrial tachycardia occurring during ablation of cfae (defined as cl \> 200 msec und stable activation sequence). exclusion criteria: -

Keywords: atrial fibrillation ablation atrial flutter
special investigation in patients with psoriatic arthritis (psa) (working productivity and activity impairment [wpai])

Conditions: Psoriatic Arthritis

Summary: a special investigation (post marketing observational study \[pmos\]/non-mandatory) of humira® in japanese psoriatic arthritis patients who are engaged in paid work.


Eligibility criteria:
inclusion criteria: * paid workers (including part-time) with psoriatic arthritis, who have never administered adalimumab, and are diagnosed by classification of psoriatic arthritis (caspar) criteria exclusion criteria: * subjects showing decreased basic activities of daily life such as hospitalization and bedridden * subjects with contraindications to adalimumab

Keywords: psoriatic arthritis
low-intensity physical-cognitive exercise and cognitive function

Conditions: Mild Cognitive Impairment

Summary: this study aims to examine the effects of low-intensity, combined physical-cognitive exercise on cognitive function of older people with mild cognitive impairment (mci) and identify the mechanisms by which this exercise protocol exerts cognitive function. older adults with mci will be recruited to either an exercise or a control group. low-intensity, combined physical-cognitive exercise will be prescribed to the exercise group 3 times per week for 3 months while the control group will maintain their routine lifestyle. it is hypothesized that at the end of the trial, participants in the exercise group will demonstrate significant improvement in cognitive performance and circulating biomarkers compared to baseline and the control group.

accumulating evidence suggests that dementia may be preventable, especially at an early stage. mild cognitive impairment (mci), a preclinical phase of dementia, is a potentially reversible condition as several individuals with mci could revert to normal level of cognition. exercise has shown promising evidence of neurocognitive protection, however, not all studies reported such benefits. type and intensity of exercise are two main factors that have often been accounted for discrepancies in previous findings. based on previous evidence, low-intensity and combined physical-cognitive exercise might give the best result for cognitive enhancement. thus, this study aims to examine the effects of low-intensity, combined physical-cognitive training on cognitive function of older people with mci and identify the mechanisms by which this exercise protocol exerts cognitive function in individuals with mci. a single-blinded, randomized controlled trial will be conducted. older adults with mci will be recruited to either an exercise or a control group. low-intensity, combined physical-cognitive exercise will be prescribed to the exercise group 3 times per week for 3 months while the control group will maintain their routine lifestyle. outcome measures will be assessed at baseline and after a 3-month exercise. the primary outcome measures will be cognitive performance (specific and global cognitive function) and plasma brain-derived neurotrophic factor (bdnf). the secondary outcomes will include physical performance (functional mobility and strength), interleukin 6 (il-6), fibroblast growth factor 21 (fgf21), and metabolomic profiles. intention-to-treat method will be applied for data analyses.

Eligibility criteria:
inclusion criteria: * meeting the criteria for mci (or mncd) based on the recent dsm-v criteria * comprehend instructions and able to comply with the study procedures * not taking any medications for their cognition and not planning to start medications during the study trial exclusion criteria: * presence of medical condition(s) unsafe to exercise or affect cognition and mobility * presence of depressive symptoms * exercise regularly

Keywords: mild cognitive impairment low intensity exercise cognitive function fibroblast growth factor 21
early diagnosis of pseudoprogression using 11c-methionine pet-mri after concomitant radiochemotherapy treatment for glioblastoma.

Conditions: Glioblastoma

Summary: pseudoprogression is a phenomenon related to post-treatment rearrangements (including radiation necrosis). it appears early in the first year after treatment and accounts for 30 to 50% of patients followed with glioblastoma. on mri (current gold standard with international therapeutic response evaluation criteria rano 2010), pseudoprogression is manifested by a progression of morphological abnormalities (contrast enhancement, flair hypersignal) and can simulate tumor recurrence, even though the corticosteroid improved or kept clinical symptoms stabilized. in view of prognosis, the current diagnostic tools have not enough diagnosis accuracy for differentiation between pseudo-progression and early tumor recurrence, and are based on mri retrospective analysis (2-3 months after). recurrence of glioblastoma, is characterized by a higher amino acid metabolism than pseudoprogression, also 11c-methionine (11c-met), positron emitting radiotracer, showed promising results to differentiate these two entities. to date, hybrid 11c-met pet-mri studies remains limited to small sample size (a few dozen patients), and none focuses exclusively on glioblastoma. hypothesis of our study is that 11c-met pet-mri may be performed as a first-line mri for suspected pseudoprogression and may changes therapeutic decision making and also patient prognosis. the main objective is to evaluate the performance of hybrid pet-mri imaging with 11c-met to differentiate pseudoprogression from glioblastoma recurrence in patients treated with surgery and radiochemotherapy, compared to multimodality mri).


Eligibility criteria:
inclusion criteria: * patients aged 18 or over, * patient with glioblastoma treated by radiochemotherapy with temozolomide, * patient with suspicion of pseudoprogression between the 1st and 12th month after the end of concomitant chemoradiotherapy, * patient receiving a social security scheme, * patient for whom informed and written consent to participate has been obtained, exclusion criteria: * subject under safeguard of justice (tutelage, curatorship), * minor patient, * patient without signs of progression mri (stable disease or good response to treatment according to the rano 2010 criteria), * clinical or radiological progression justifying a change of treatment, * patient not able to decide and with refusal of the family entitled to continue research. * pregnant woman, breastfeeding or old enough to have children but without effective contraception, * contraindication to performing an mri: permanently fixed metal parts (pacemaker, cerebral clip, cochlear implant, pin or screw for recent bone fracture, dental equipment, metal splinters), claustrophobia, * contraindication to gadolinium according to ansm 2017 recommendations

Keywords: glioblastoma 11c-methionine pet-mri sensitivity temozolomide radiotherapy
evaluating postoperative non-opioid pain management utilizing local anesthetics coupled with modulated coagulation

Conditions: Opioid Pain Medication

Summary: this study is a prospective randomized trial examining the effect of topically combined antifibrinolytics (tranexamic acid) with local anesthetics in all electively created surgical wound beds in hand surgery to provide long term pain relief and decrease the use of postoperative narcotics.

the aim of the study is to provide long term pain relief and decrease the use of postoperative narcotics. all treatments are applied topically to the surgical bed prior to closure of the skin. each of the drugs used in this study are food and drug administration (fda) approved and routinely used for pain relief. however, the route of administration of the drugs and addition of tranexamic acid or aminocaproic acid is considered off-label (outside of the fda-approved indications) and therefore investigational.

Eligibility criteria:
inclusion criteria: * age 18 or older * any patient undergoing elective hand surgery exclusion criteria: * any patient with a traumatic open wound (only surgically created wounds will be included) * history of chronic pain * history of narcotic addiction * history of recreational drug dependency * history of psychiatric pathology * allergy to local anesthetics, recombinant human thrombin or tranexamic acid * any patient receiving a supra/infraclavicular block for anesthesia
comparative study of superficial cervical plexus block and nerve of arnold block and incidence of ponv for inner ear surgery

Conditions: Anesthesia, Pediatrics, Surgery

Summary: the investigators would like to compare the therapeutic and cost effectiveness of established therapies for postoperative nausea and vomiting to regional nerve blocks of the head and neck area an intervention known for analgesia but for which the antiemetic effects hasn't been entirely explored. the rational is based on the knowledge of the anatomical innervation of the inner ear and the role of the parasympathetic nervous system in the emetic act. a lot of focus has been given on its counterpart the sympathetic nervous system and its role in painful conditions. the investigators believe that the nerve blockade of the parasympathetic innervation can have some beneficial effect in the post-surgical patient.

the researchers hypothesize another potential antiemetic mechanism by the blockade of the auricular branch of the vagus nerve at the ear canal (commonly described as nerve of arnold) in conjunction with a block of the greater auricular nerve and lesser occipital nerve at the superficial cervical plexus level. the block would cover both the sensory innervation and of the ear canal and the inner ear. a regional anesthetic block prior to the surgical intervention on the inner ear at the superficial cervical plexus block is performed. this latter is a branch of the vagus nerve at the superficial cervical plexus (erb's point). the block would inhibit the vagal afferent to area postrema through inhibition of afferent vagal input to the medullary center. the emetic act (vomiting) is a highly integrated physiologic reflex involving both the somatic and autonomic nervous system. researchers do not know how much of a relation there is between the vagal nerve branches involvement and incidence of nausea and vomiting effects are from the inner ear injury and or the inflammatory response type of response triggering the area postrema. the usual prophylactic treatment of ponv (post operative nausea and vomiting) has been limited to anti-emetics such as dexamethasone along with aggressive fluid therapy and adequate analgesia. investigators are proposing to conduct a comparative study of the therapeutic and cost effectiveness of regional anesthesia and antiemetic therapy in the prevention and treatment of ponv in children undergoing inner ear surgical procedures.

Eligibility criteria:
inclusion criteria: * patient age 1-18 yo * scheduled to have cochlear implantation, tympanomastoidectomy, inner ear surgery * past history of ponv susceptibility exclusion criteria: * patient/ parents refusal * infection at the site of local anesthetic injection * known coagulopathy * existing vp shunt * severe mental disability * any known allergic to dexamethasone (decadron) and/or ondansetron ( zofran)

Keywords: post operative nausea vomiting inner ear surgery
simultaneous fluorodeoxyglucose positron emission tomography (pet) and magnetic resonance (mr) in visual snow syndrome

Conditions: Visual Snow Syndrome

Summary: visual snow syndrome (vss) is a neurologic condition where patients experience tiny flickering dots in their entire visual field. it has been reported that the brain consumes more glucose in the lingual gyrus (a subdivision of the occipital cortex) and that this also shows increased volume of grey matter (neurons and supporting cells). in this study, the investigators apply fluor-18 fluorodeoxyglucose positron emission tomography with magnetic resonance imaging (18f-fdg pet/mr) in patients with vss and compare this to healthy controls. aside from an analysis in each brain volume element (voxel), the accuracy of classifying groups based on a volume-of-interest (voi) analysis of both pet and mr is studied, lastly, this is also compared to a visual assessment of the pet and mr images.

aim : prospective measurement of brain glucose metabolism and structural integrity in the brain of subjects with visual snow syndrome (vss). voxel-based and volume-of interest comparison to age matched healthy controls retrospectively obtained on the same simultaneous pet/mr imaging system. hypothesis : 1/ vss patients show overactivation of parts of the visual system, in particular the lingual gyrus, which is likely related to larger volume of the gyrus on structural imaging. 2/ discrimination of vss patients versus controls can be done by visual read of fdg pet and/or volume-of-interest based discriminant analysis. methods : recruitment through neurology practice specialised in vss, detailed history taking and assessment of in/exclusion criteria, scanning with simultaneous18f-fdg pet/mr signa ge healthcare. analysis : visual assessment, group-based voxel and volume-of-interest based analysis (fdg pet, volumetry t1 mri) with appropriate statistics and corrections for multiple regional comparisons. discriminant analysis on voi based data. dual observer scoring of visual data and assessment of accuracy, sensitivity and specificity of visual image analysis compared to clinical final diagnosis.

Eligibility criteria:
group 1: vss patients inclusion criteria: * m/f, age 18-85, * diagnosis of vss by an experienced neurologist : dynamic, continuous, black and white tiny dots in the entire visual field lasting longer than 3 months, with at least two additional visual symptoms exclusion criteria: - other underlying neurological conditions inclusive ophthalmological examinations group 2 : controls inclusion criteria: * age 18-85 years, m/f, in general healthy condition * normal neurological examination, mini-mental state examination (mmse) ≥ 28, beck's depression inventory (bdi) score ≤ 9, and a normal structural volumetric mri. exclusion criteria: * history of major internal pathology, neurological and/or psychiatric disorders (including psychosis, depression, and anxiety), * history of frequent migraine attacks, substance abuse or current use of any central acting medication * first-degree relatives with dementia.

Keywords: fdg pet pet/mr volumetry visual analysis discriminant analysis
identification of risk factors for recurrence of low back pain and occupational repercussions

Conditions: Low Back Pain

Summary: low back pain (lbp) is the leading cause of disability and one of the most common reasons for physician visits in primary care, with a 33 % rate of recurrence during the first year, converting lbp into a chronic condition. the french high healthy authority recommend early occupational oriented intervention associated with a multidisciplinary rehabilitation program. however even if these recommendations are taken into appropriate account, risk for recurrence of low back pain and occupational repercussions often occured. this study aims to identify the risk factor(s) of sick leave after a rehabilitation stay in outpatients and thus adapt cares provided to the patients in respect of their needs and expectations.


Eligibility criteria:
inclusion criteria: * men and women over 18 years old * able to understand and respect the protocol requirement * who signed the consent prior to any other procedure protocol * patients suffering from chronic lower back or lumbo-radicular pain since more than 3 months * employee bellow 3 years before retirement * patients included in a multidisciplinary rehabilitation program and occupational medicine exclusion criteria: * major patients under guardianship/curator/legal protection * pregnant patients * obese patients with bmi (body mass index) \> 35 (grade 2) * patients suffering from neurological pathology * patients suffering from chronic lower back or lumbo-radicular pain since less than 3 months * patients suffering from chronic lower back pain with inflammatory or tumoral or infectious ethiology