Kornimate/medical-research-clean huggingface dataset:
effect of chitosan phonophoresis on cubital tunnel syndrome

Conditions: Cubital Tunnel Syndrome; Ulnar Nerve Entrapment at Elbow; Ulnar Nerve Compression; Ulnar Nerve Entrapment Syndrome

Summary: - this study will be conducted to answer the following question: is there a statistically significant effect of chitosan phonophoresis on ulnar nerve conduction velocity, pain level \& function in patients with mild to moderate cubital tunnel syndrome? - fifty-four subjects suffering from mild to moderate cubital tunnel syndrome according to modified mcgowan grading system (palmer \& hughes, 2010) from both sexes diagnosed clinically by electromyography will be recruited for this study. the age of the participants will range from 20 - 40 years old. participants with body mass index between 18.5 and 24.9kg/m2. ems physio ltd ultrasound device will be used in combination with chitosan nanoparticles gel. electrodiagnostic test will be performed for ulnar nerve conduction velocity using neuropack s1 meb-9004 nihon koden, japan. visual analogue scale (vas) will be used to determine pain level. quick dash will be used to determine hand function.patients will have 3 sessions per week for 5 weeks.


Eligibility criteria:
inclusion criteria: 1. fifty-four patients suffering from mild to moderate cubital tunnel syndrome from both sexes according to modified mcgowan grading system (palmer \& hughes, 2010) \& have motor conduction velocity across the elbow less than 50 m/s or the difference between the motor conduction velocity across the elbow and that below the elbow exceeds 10 m/s (padua et al., 2001). 2. age ranging from 20-35. 3. all participants will have body mass index between 18.5 and 24.9 kg/m2. exclusion criteria: * 1- diabetic patients. 2- cardiovascular patients 3- patients with cervical spondylosis 4- patients with cervical disc prolapsed 5- patients with thoracic outlet syndrome 6- patients with carpal tunnel syndrome. 7- pregnant women 8- patients with fibromyalgia 9- patients with epicondylitis 10- patient with previous elbow injuries 11- patient with breast cancer. 12- patient with guyon canal syndrome 13- smokers
the extension of hapo follow-up study

Conditions: Hyperglycemia; Pregnancy; Overnutrition; Maternal Obesity During Childbirth; Diabetes Mellitus; Cardiovascular Diseases; Gestational Diabetes Mellitus in Pregnancy; Hypertension

Summary: the prevalence of diabetes mellitus (dm) and cardiovascular disease (cvd) escalate remarkably worldwide and obesity becomes an epidemic disease. this study is interested in how the model of developmental origin of health and disease (dohad) influence individual's health status as they reach young adulthood. since the mothers from hapo study have not been subjected to antenatal treatment on the various degree of maternal hyperglycaemia in pregnancy, this would be an unique cohort that allows determination of the effect of various degree of maternal hyperglycaemia below the level of overt dm, on children's cardiometabolic risk in chinese population.

the investigators recruited 1760 chinese pregnant women between 2000 and 2005. the hapo study investigated whether any adverse outcome was associated with mild degree of gdm. all mothers underwent a 75-gram ogtt at 24-32 weeks gestation, but clinicians were blinded to the results as long as the fasting pg was ≤ 5.8 mmol/l \& 2-hour pg ≤ 11.1 mmol/l. the maternal serum c-peptide and hba1c, cord serum c-peptide and early neonatal pg, pregnancy outcome and the neonatal anthropometric parameters are available for future study. this is so far the largest cohort in a chinese population who has been investigated for glycaemia during pregnancy, but with ogtt results remained undisclosed to subjects and clinicians. this unique cohort can allow us to study the effect of in-utero hyperglycemia on the cardiometabolic risks at childhood, adolescence and adulthood. eligible subjects are all mother-child pairs participating in the original hapo study. children born preterm before 37 weeks of gestation, non-chinese and whose mother's ogtt result were unblinded during pregnancy will be excluded.the family (the child and the mother) will be invited for a third follow-up assessment.

Eligibility criteria:
inclusion criteria: * mother-child pairs who had been assessed in hapo follow-up study at either 7 years or 11-14 years old exclusion criteria: * children born preterm before 37 weeks of gestation * non-chinese * mothers' ogtt results were unblinded during pregnancy

Keywords: hyperglycemia pregnancy overnutrition maternal obesity diabetes mellitus cardiovascular diseases gestational diabetes mellitus hypertension young adulthood
pulmonaryhypertension in copd at different levels of smoking

Conditions: Pulmonary Hypertension

Summary: to identify predictors of pulmonary hypertension in copd patients and its relation to different levels of smoking

copd is a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, expectoration and/or exacerbations) due to abnormalities of the airways (bronchitis, bronchiolitis) and/or alveoli (emphysema) that cause persistent, often progressive, airflow obstruction.it is also the most common cause of deaths in patients with chronic respiratory disease, the fatality rate in usa is 0.41%.pulmonary hypertension is the most common serious complication in copd patients ; which occurs in up to 30% of patients and increases the mortality rate.smoking is the leading cause of chronic obstructive pulmonary disease (copd) smoking is also a trigger for copd flare-ups.smoking damages the air sacs, airways, and the lining of your lungs. injured lungs have trouble moving enough air in and out, so it's hard to breathe

Eligibility criteria:
inclusion criteria: * 1.all patients admitted to chest department or presented to our outpatient clinic with clinical and functional diagnosis of copd among both sexes will be included 2.age \>18 years old exclusion criteria: * 1.patients under 18 years old. 2.pregnant patients. 3.patients with history hypertension or valvular diseases 4.cardiomyopathic patient 5.patients with concomitant obstructive sleep apnea 6.patients with collagen vascular disease 7.patients with thrombo-embolic disease 8. patients with any chronic chest disease other than copd
remote monitoring and support for patients with schizophrenia, schizoaffective or bipolar disorder on adherence

Conditions: Schizophrenia; Schizoaffective Disorder; Bipolar Disorder

Summary: moma call center will provide unique service -remote monitoring and support for mental health patients .the aim of this reserch is reducing hospitalization and improve adherence, by reaching out and there for monitoring very closely .

"moma" call center is a result of collaboration between maccabi health services and the gertner institute of epidemiology and health policy research. the call center provides remote continuous monitoring and support for patients with chronic illnesses, and has been found useful for improvement in treatment adherence and other clinical measures in patients with diabetes and chf. the current project focuses on patients diagnosed with schizophrenia, schizoaffective disorder and bipolar disorder. patients that suffer from these disorders are prone to low adherence and are at risk for discontinuation of treatment and frequent relapses. the advantages of the "moma" call-center include high availability, reaching out, collaboration between treatment centers and agents, and continuous remote monitoring. we hypothesize that these factors will enable improvement of support provided to these patients, early detection of their needs, connection with community care agents, monitoring of treatment adherence, and remote interventions targeted towards prevention of relapse.

Eligibility criteria:
inclusion criteria: men \& women, 1. age 18-60 , 2. "maccabi health service" patients with diagnosis of: schizophrenia, schizo - effective or bipolar dis. 3. must have 30 days or more of hospitalization (during 3 years). treated with psychiatric medication. 4. living independently or with a help of a caregiver. 5. is able to provide written informed consent. exclusion criteria: 1. violent, or suicidal. 2. drug\\ alcohol, addiction, 3. end stage disease (cancer, esrf act.) 4. non - in depended and without care giver/legal guardian
real world efficiency of trastuzumab in early breast cancer

Conditions: Breast Cancer

Summary: aim to determine the value of trastuzumab in the early breast cancer setting in the netherlands. research questions / objectives 1. is adjuvant trastuzumab in daily practice effectively used, that is, how and to whom is it given? 2. is the introduction of trastuzumab in early breast cancer cost-effective for the netherlands? to address the research questions (objectives), the following outcome measures will be determined: clinical outcome measures 1. actual trastuzumab administration as opposed to planned trastuzumab administration 2. selection criteria for chemotherapy and trastuzumab in daily practice 3. immediate and longterm toxicities due to adjuvant treatment, specifically cardiac 4. disease-free, breast cancer specific, and overall survival in relation to trastuzumab economic outcome measures 5. volumes and costs of diagnostic tests and therapies including those for (distant) relapse 6. cost-effectiveness of trastuzumab in clinical trials versus in real world


Eligibility criteria:
inclusion criteria: * all patients diagnosed with invasive stage i-iii breast cancer in the years 2005, 2006 and 2007 in the participating 5 hospitals. exclusion criteria: * distant metastasis at the time of the primary diagnosis
randomized clinical trial by conglomerates on the efficacy of maintenance of physical exercise in myocardial ischemia

Conditions: Myocardial Ischemia; Physical Exercise

Summary: main objective: to assess the efficacy of a phase iii cardiac rehabilitation program (crp), based on counseling in the maintenance of physical exercise (time of physical exercise per week) for patients with myocardial ischemia (mi), once the supervised physical exercise program of phase ii of crp is completed. secondary objectives: to assess the efficacy of a phase iii program of crp based on counseling in the maintenance of physical exercise for the patient with mi in: 1) the energy expenditure per week, 2) body mass index and abdominal perimeter, 3) control of cardiovascular risk factors (smoking, high blood pressure, dyslipidemia and diabetes mellitus), 4) quality of life related to health, 5) assess the adherence to cardiac pharmacological treatment. method: randomized clinical trial in conglomerates, open and controlled. the intervention group will carry out phase iii of crp based on counseling in the maintenance of physical exercise. the control group will receive the usual care. the main outcome will be the physical exercise time per week after finish the supervised physical exercise program of phase ii of crp and at 6 and 12 month later according to the 7-day physical activity recall.


Eligibility criteria:
inclusion criteria: * patients diagnosed with myocardial ischemia, angina pectoris, other specific forms of chronic ischemic heart disease or unspecified ischemic heart disease. * patients who have completed the supervised physical exercise program of phase ii of the crp. * absence of cognitive deficit (pfeiffer test: 0-2 mistakes). * sufficient functional capacity to follow the crp (barthel index \>60) * residence in catchment area of bages and moianès. * providing signed informed consent. exclusion criteria: * symptoms of right heart failure producing pulmonary hypertension. * dyspnea caused by severe pulmonary pathology. * additional comorbidities affecting the prognosis of cardiac disease. * major comorbidities or limitations that could interfere with the exercise training programme.

Keywords: cardiac rehabilitation myocardial ischemia physical exercise cardiovascular risk factors randomized controlled trial
utility of adding mr fusion to standard us guided prostate biopsy

Conditions: Prostate Cancer; Prostate Adenocarcinoma

Summary: the purpose of this study is to utilize this technology in the early detection and staging of pathologic states within prostate cancer patients using the information obtained on mpmri and serum biomarkers from the patient's blood (if collected). ultimately, investigators hope to improve the diagnostic accuracy and treatment selection process for these patients. applying the fusion software which adds mpmri to ultrasound images in real time, to an otherwise clinically standard but non-targeted ultrasound-guided prostate biopsy procedure will help with accurate and early diagnosis of prostate cancer.


Eligibility criteria:
inclusion criteria: 1. able to give informed consent 2. male - age \> 18 3. mpmri within the previous 6 months (pirads 3,4,5, all stages of pca) 4. scheduled for trus biopsy for prostate lesion or mass exclusion criteria: 1. age under 18 years of age. 2. female 3. pre-existing blood dyscrasias 4. inability to perform trus due to anal sphincter closure/surgery 5. patients needing general anesthesia 6. patients allergic to lidocaine 7. patients allergic or unable to take antibiotics
the clinical study of making the evidence with application of da vinci-robot assisted low anterior resection in rectal cancer

Conditions: Rectal Cancer

Summary: the clinical study of making the evidence with application of da vinci-robot assisted low anterior resection in rectal cancer


Eligibility criteria:
inclusion criteria: * 75 \> age \> 20 * rectal cancer * non-distance metastasis * agree with this study exclusion criteria: * benign prostate hyperplasia * previous history of urinary bladder or prostate gland operation * severe erectile dysfunction * defined as patients whose erectile scores were less than 10 in a preoperative questionnaire of the international index of erectile function (iief)
pilot trial comparing computerised cognitive exercises to tetris in adolescents with adhd

Conditions: Attention Deficit/Hyperactivity Disorder

Summary: the purpose of this study was to examine the feasibility and efficacy of computerized cognitive exercises from scientific brain training (sbt), compared to the computer game tetris as an active placebo, in a pilot study of adolescents with attention-deficit/hyperactivity disorder (adhd).

objective: to examine the feasibility and efficacy of computerized cognitive exercises from scientific brain training (sbt), compared to the computer game tetris as an active placebo, in a pilot study of adolescents with attention-deficit/hyperactivity disorder (adhd). method: eighteen adolescents with adhd were randomized to treatment or control intervention for seven weeks. outcome measures were cognitive test, symptom and motivation questionnaires.

Eligibility criteria:
inclusion criteria: 1. a clinical diagnosis of hyperkinetic disorder (f90.0, corresponding to adhd combined type) (who, 1993); 2. age between 14-17 years; 3. iq \> 80. exclusion criteria: 1. pharmacological treatment other than methylphenidate, dexamphetamine and/or atomoxetine; 2. comorbid conduct disorder, autism spectrum disorders or major depression; 3. history of head trauma or verified neurological disease; 4. motor or perceptual disabilities which prevented the use of a computer; 5. medical illness that required treatment; 6. no access to a computer and internet at home.
lung ultrasound as alternative to radiography in thoracic surgery

Conditions: Thoracic Surgery; Ultrasonography

Summary: this projects aim is to study the effects of substitute conventional chest x-ray with lung ultrasound for patients undergoing thoracic surgery. participants in the study will be randomized to either ultrasound or routine chest x-ray as the primary method of diagnosis after having received surgery to their lungs.

modern lung surgery involves a variety of procedures that expose patients to the risk of developing postoperative complications (ppc). in lung surgery such as resections or lobectomies where a part of the lung tissue is removed, so-called single-lung ventilation is used. through this technique, the lung that is operated on collapses, while ventilation is directed to the lung that is not operated on. when the operation is over, the structures of the lung are sewn together and the collapsed lung is inflated again. at this stage, it is important to ensure that the expansion of the lung is adequate. it is also important for the continued expansion of the lung that there is no air leakage from the lung to the pleural cavity. therefore, there is initially a drainage in the pleural cavity to prevent both bleeding and air leakage. postoperatively, several x-ray examinations are performed before the patient is discharged to ensure adequate lung expansion. lung ultrasound is a well-established method that is based on physical artifacts that arise in the interaction between ultrasound and various conditions in the lung tissue. the method is used in most of the questions that are usually asked even in chest x-rays and other conventional techniques but has the advantages of being both cost- and time-effective and does not involve the radiation dose that conventional x-rays involve. the study aims to investigate whether lung ultrasound can replace conventional chest x-rays in patients who have undergone lung surgery. the research subjects will be randomized to undergo postoperative lung ultrasound or conventional chest x-rays after lung surgery. previous research has shown the possibility of abandoning x-ray radiation in favor of ultrasound in most scenarios. however, randomized studies are generally lacking, especially in this population.

Eligibility criteria:
inclusion criteria: * segmental, partial, or wedge resection lung surgery, or lobectomy. * written informed consent * available research team for measurements. exclusion criteria: * pregnancy * re-surgery due to complications related to the original surgery * need for critical care or admittance to the icu. * patient or physician choice of withdrawal from the study

Keywords: thoracic surgery lung ultrasound chest x-ray nurse
pfa-100 responsive to effect of energy drinks on platelet function

Conditions: Platelet Function; Thrombosis

Summary: this study evaluates the responsiveness of the platelet function analyzer (pfa-100) to the effect of energy drinks on platelet function. participants' will have blood drawn prior to and 60 minutes after ingesting 250ml of a commercially available sugar-free energy drink.

two previous studies have demonstrated increased platelet aggregation 60 minutes after drinking a commercially available sugar-free energy drink. these studies utilized traditional platelet function studies, such as light transmission aggregometry (lta), where platelet function is examined while adding varying concentrations of a panel of agonist to platelets. these studies are technically difficult, time intensive studies requiring specialized laboratories. they are relatively non-physiologic and do not mimic platelet response to vessel wall damage. other tests better represent the reactions to vessel wall damage, including the pfa-100, which measures platelet aggregation and adhesion under conditions of high shear. overall, pfa-100 is less expensive, requires less technical skill, and is less time consuming than lta. it has been utilized in bleeding disorders and is demonstrating promise as a marker of thrombophilia. pfa-100 has demonstrated sensitivity to drug and dietary effects. it has also shown differences in closure time between sedentary and athletic individuals pfa-100 has not been used to investigate the effect of energy drinks.

Eligibility criteria:
inclusion criteria: * a history of consuming at least one energy drink beverage in the past 6 months without adverse effects; * engage in moderate to strenuous physical activity more than 3 days per week. exclusion criteria: * known thromboembolic risk including protein c or s deficiency, anti-thrombin iii deficiency, factor v leiden; * history of thromboembolic event; * current or previous anti-coagulation therapy, anti-platelet therapy, calcium antagonists; - current tricyclic antidepressant therapy, current selective serotonin re-uptake inhibitor therapy; antibiotic therapy; or famotidine therapy; * acute illness; * pregnancy; * hemophilia; * significant history of cardiovascular disease and/or diabetes mellitus; * history of adverse effect of energy drinks. * inability to comply with pre-test dietary and activity requirements.
adherence to the mediterranean diet among women attending mammographic screening

Conditions: Breast Cancer Prevention

Summary: the prevcar study is a cross-sectional investigation aimed at evaluating dietary habits among women undergoing breast cancer screening. specifically, the study focuses on adherence to the mediterranean diet, a dietary pattern recognized for its potential protective role against chronic diseases, including breast cancer. the prevcar study will include approximately 35,000 women aged 18 and older who participate in the "prevention caravan" and complete both the breast cancer screening and the medas (mediterranean diet adherence screener) questionnaire. this 14-item questionnaire measures dietary behavior, with scores reflecting levels of adherence to the mediterranean diet. the primary objective of the study is to determine the average medas score among participants. secondary objectives include analyzing how adherence varies across different known breast cancer risk factors-such as age, menopausal status, hormonal therapy use, and reproductive history-and assessing the prevalence of malignant breast lesions identified through the screening.


Eligibility criteria:
inclusion criteria: * women who participate in the "prevention caravan" program; * women who undergo breast cancer screening, including mammography or breast ultrasound; * women who complete the medas questionnaire. exclusion criteria: * women who do not participate in the "prevention caravan" program; * women who participate in the "prevention caravan" program but undergo screenings or consultations for conditions other than breast cancer, such as gynecological cancers, thyroid ultrasounds, or dermatological evaluations; * women who do not complete the medas questionnaire.