Kornimate/medical-research-clean huggingface dataset:
omega-3 unsaturated fatty acid improves cognitive function in patients with depression

Conditions: Cognitive Impairment; Depression

Summary: the aim of this study was to evaluate the effect of n-3pufas on cognitive function in patients with depression

depression is often accompanied by cognitive impairment. at present, there is no effective drug to improve the cognitive impairment in patients with depression, and the social function and quality of life of patients are affected in varying degrees. n-3 polyunsaturated fatty acids (n-3pufas) are food products with high safety and few adverse reactions. previous clinical trials have also suggested that n-3pufas may help to improve cognitive impairment in patients with depression, but the reported results are different. we have developed a new generation of n-3pufas optimal proportion combination products and found good cognitive improvement effect in animal models of depression. therefore, this clinical research project will screen out the depressive patients with cognitive impairment through the cognitive function battery test (mccb) tool for schizophrenia. on the basis of routine treatment of depression, these patients will be added with the cognitive improvement formula n-3pufas capsule developed by us to explore the effect of n-3pufas formula on cognitive impairment of depression.

Eligibility criteria:
inclusion criteria:① the patients met the diagnostic criteria of dsm-5 major depressive disorder; ② aged 18-55 years; ③ hamilton depression scale score of 24 items ≥ 20 points; ymrs score \< 6 points; ④ the score of wms-ii spatial span (assessment of working memory) in mccb tool was less than or equal to its mean half standard deviation; ⑤ antidepressant types had not been adjusted in recent 2 weeks; 6) right handedness; 7) primary school had no change in the types of antidepressants the patients or their family members are willing to participate in the study and sign the informed consent. exclusion criteria:① merge with any other mental disorder; ② patients with history of brain organic disease or traumatic brain injury and physical diseases; ③ abusers of drugs, alcohol or other psychoactive substances; ④ pregnant, lactating women and postpartum women; ⑤ refractory depression; ⑥ severe suicide risk (c-ssrs assessment); ⑦ mect treatment in recent three months; ③ continuous use of diazepam drugs in recent three months; ⅸ long-term use of npufas in recent three months; ⑩ long term use of anti-inflammatory drugs in the past three months.
coronary revascularization outcomes within necessary sex and gender aspects

Conditions: Coronary Artery Disease; Ischemic Heart Disease; Coronary Artery Bypass Grafting

Summary: the aim of this observational single-centre study is the optimization of coronary artery bypass grafting (cabg) tactics considering gender and sex approach on the basis of complex comparative evaluation of surgical revascularization techniques. patients enrolled in the study are divided into groups based on sex, as well as into stratum of surgery techniques. objectives of the study are: 1. to evaluate the preoperative profile of women and men referred for cabg. 2. to give a comparative assessment of cabg outcomes in the short-term and long-term postoperative period in patients of both sexes. 3. to carry out the comparative analysis of short-term and long-term outcomes of different cabg techniques for each sex. 4. to analyse the causes and identify predictors of complications and mortality after cabg in the female and male cohort. 5. to determine an optimal selection strategy of surgical revascularization technique for patients of different sexes based on the conducted comparative gender-sex analysis of modern coronary surgery techniques.

this retrospective-prospective single-centre study aims to conduct an in-depth comparative analysis of the impact of preoperative profile and range of surgical techniques in coronary artery bypass grafting (cabg) surgery on short-term and long-term outcomes in women and men. the study included a sample of 400 patients (200 women and 200 men) who underwent cabg between january 2016 and july 2023. patients enrolled in the study were divided into groups based on sex with the following propensity score matching (psm) analysis, as well as into stratum of surgery techniques - oncab (on-pump coronary artery bypass grafting), opcab (off-pump coronary artery bypass grafting), nta (no-touch aorta technique), micscab (minimally invasive multiple coronary artery bypass grafting). furthermore, the impact of multiple arterial grafting (mag), total arterial revascularization (tar), composite and sequential grafting on outcomes was analyzed for each sex. included patients were evaluated for 112 various parameters of preoperative profile, intraoperative characteristics, in-hospital and long-term postoperative data. perioperative data was obtained from the centre's digital medical information system. long-term data was gathered from the regional state health information system by tracking patients' chronology of outpatient visits and complaints, subsequent hospital admissions, clinical and laboratory tests.

Eligibility criteria:
inclusion criteria: * patients with multivessel coronary artery disease requiring cabg; * age ≥ 18 years; * patients residing in the perm region. exclusion criteria: * single-vessel cabg; * redo cabg; * concomitant coronary artery disease and caroid artery disease and/or valvular disease and/or rhythm disorders requiring surgical treatment

Keywords: coronary artery bypass grafting revascularization opcab oncab nta micscab multiple arterial grafting sequential grafts composite grafts cardiac surgery women sex gender
preferences of patients treated with oral cancer drugs and informal caregivers for pharmaceutical consultation in hospital

Conditions: Preference, Patient; Pharmacist-Patient Relations; Caregiver; Cancer

Summary: to ensure the safe use of oral anticancer drugs, oncology pharmacy consultations (opcs) have been established in france. their goal is to provide the patient with the means to identify, prevent and limit adverse effects and to know who to refer to in case of a serious adverse effect, perform a pharmaceutical analysis of the prescription, and participate in the improvement and evaluation of overall compliance. opcs are conditioned by the needs, expectations, and involvement of the patients in their care. in healthcare, patients are increasingly encouraged to play an active role in the knowledge and management of their health, express their concerns and preferences, and participate in medical decisions. thus, it is essential to elicit their preferences. the discrete-choice experiment (dce) is the validated and recommended method of the international society for pharmacoeconomics and outcomes research for such a task.

to ensure the safe use of oral anticancer drugs, oncology pharmacy consultations (opcs) have been established in france. their goal is to provide the patient with the means to identify, prevent and limit adverse effects and to know who to refer to in case of a serious adverse effect, perform a pharmaceutical analysis of the prescription, and participate in the improvement and evaluation of overall compliance. opcs are conditioned by the needs, expectations, and involvement of the patients in their care. in healthcare, patients are increasingly encouraged to play an active role in the knowledge and management of their health, express their concerns and preferences, and participate in medical decisions. thus, it is essential to elicit their preferences. the discrete-choice experiment (dce) is the validated and recommended method of the international society for pharmacoeconomics and outcomes research for such a task.

Eligibility criteria:
of patients: main inclusion criteria: * patients with lung, prostate breast, prostate or renal cancer; * patients with oral cancer drugs; * patients accepted to take par in pharmaceutical consultation in hospital.

Keywords: preference, patient pharmacist-patient relations cancer of colon cancer, breast lung cancer prostate cancer renal cancer caregiver
a study of combination therapy with guselkumab and golimumab in participants with moderately to severely active crohn's disease

Conditions: Crohn's Disease

Summary: the purpose of this study is to evaluate the efficacy of jnj-78934804 at week 48 compared to guselkumab and golimumab.


Eligibility criteria:
inclusion criteria: * diagnosis of crohn's disease (cd) for at least 3 months prior to baseline * confirmed diagnosis of moderate to severe cd as assessed by crohn'
p-wave terminal force in patients with atrial fibrillation.

Conditions: Atrial Fibrillation

Summary: it is suggested that p-wave terminal force (ptf), a product of the amplitude (pam) and the duration (pt) of the terminal phase of p-wave in lead v1, shows early delay in left atrial conduction, observed earlier that the dilatation of left atrium. the aim is to follow pt, pam and ptf changes during 5-year follow-up (5fu) and examine the relation of these changes to the number of af episodes requiring hospitalisation (hosp) for restoration of sinus rhythm (rsr).

background. it is suggested that p-wave terminal force (ptf), a product of the amplitude (pam) and the duration (pt) of the terminal phase of p-wave in lead v1, shows early delay in left atrial conduction, observed earlier that the dilatation of left atrium. aim. we aim to follow pt, pam and ptf changes during 5-year follow-up (5fu) and examine the relation of these changes to the number of af episodes requiring hospitalisation (hosp) for restoration of sinus rhythm (rsr). we hypothesise that, in patients with atrial fibrillation (af): 1. the index parameters (pt, pam, ptf), characterising left atrial repolarization, correlates the number of future hospitalisations (hosp) aimed for restoration of sinus rhythm (rsr) in 5-year follow-up (5fu) 2. in 5fu the number of hosp aimed for rsr correlates with the progression of left atrium electrical remodelling, expressed as pam5,pt5, ptf5 at 5fu.

Eligibility criteria:
inclusion criteria: * documented atrial fibrillation at admission * successful restoration of sinus rhythms documented in 12-leads ecg, * follow-up =\> 5 years exclusion criteria: * arrhythmia other than atrial fibrillation at admission, * unsuccessful restoration of sinus rhythms, * successful restoration of sinus rhythms but missing 12-leads ecg recording, * previous ablation/operation within left atrium, * follow-up \< 5 years

Keywords: atrial fibrillation p-wave hospitalization
intraoperative mri and 5-ala guidance to improve the extent of resection in brain tumor surgery

Conditions: Primary Malignant Neoplasm of Nervous System; Glioma; Glioblastoma; Metastasis

Summary: the investigators hypothesize that the rate of radiologically complete resections of contrast-enhancing brain tumors following surgeries aided by use of 5-ala induced fluorescence guidance and use of an intraoperative ultra-low field mri is higher compared to surgeries aided by 5-ala induced fluorescene alone.


Eligibility criteria:
inclusion criteria: * adult patient (\> 18 years) able to give informed consent * primary supratentorial intra-axial brain tumor exhibiting contrast enhancement suspected to be malignant glioma * tumor must be deemed completely resectable by neurosurgeon * diagnostic mri exclusion criteria: * patient unable or unwilling to give informed consent * infratentorial tumor location * tumor location in or near eloquent areas * multifocal tumor * existance of contraindications to undergo mri examination * previous surgical treatment for an intraaxial brain tumor

Keywords: primary brain tumor malignant glioma intraoperative mri 5-ala
clinical study to evaluate the efficacy of topical medications containing benzoyl peroxide and sulfur in the regression in the short time (24 hours) of moderate acne vulgaris grade ii (pimples)

Conditions: Treatment of Acne Vulgaris Grade II in a Short Period of Time.

Summary: sixty two subjects will take part in this study. the study is unic arm. the subjects used the product once and will be evaluated in the regression of pimples in the times 0,4,6,8 and 24 hours after application. a follow-up visit will be made 24 hours after initiation of treatment.


Eligibility criteria:
inclusion criteria: * subjects of both sexes aged to 12 years to 35 years * oily skin prone to acne * presence of at least three inflammatory lesions, diagnosed as grade ii acne vulgaris. * sign the informed consent form * comply the requirements and attend to study visits exclusion criteria: * pregnancy (need for urinary pregnancy test for women of childbearing age) * lactation * presence of acne conglobata and nodulocystic * pathologies associated hormonal (thyroid diseases, ovaries micropolycystic) * drug use systemic corticosteroids, anticonvulsants and / or new drugs for up to one month before to selection. * history of atopy or allergic cutaneous * history of hypersensitivity to benzoyl peroxide and sulfur * beginning or ending the use of contraceptives (for females) * intense sun exposure until one month before the evaluation

Keywords: blackheads and pimples acne vulgaris grade ii
study to investigate vagus nerve stimulation paired with motor task for remyelination and functional recovery

Conditions: Multiple Sclerosis (MS) - Relapsing-remitting; Multiple Sclerosis

Summary: the goal of this clinical trial is to learn if stimulating the vagus nerve in combination with a motor task in people with multiple sclerosis can improve motor function. the main questions it aims to answer are: * is stimulating the vagus nerve safe and feasible after demyelinating episodes? * does a paired motor task with vagus nerve stimulation improve motor function with someone who has multiple sclerosis? researchers will compare active vagus nerve stimulation to a sham stimulation to see if the paired vagus nerve stimulation can improve motor control. participants will: * come in for study visits over a six month period. study visits are three times weekly for the first month, then single follow up visits at two, three, and six months. * during study visits, participants will complete 30 minutes of the paired vagus nerve stimulation with a motor task, specifically the grooved peg test. * at various timepoints in the study, motor and disability tests will be administered to see if there are any changes in motor control for that participants. these tests include the timed 25 foot walk test, expanded disability scale, the upper extremity portion of the fugl-meyer assessment, and the multiple sclerosis impact scale - 29.


Eligibility criteria:
inclusion criteria: * all participants ages 18-65 with diagnosis of multiple sclerosis at least 30 days from last relapse * baseline grooved peg test time greater than or equal to 108 seconds for completion of the task (1 standard deviation below mean multiple sclerosis score). * ability to sign informed consent * expanded disability status scale score (or estimated) of 2.5 or greater or a clinical report of upper extremity dysfunction in their dominant hand exclusion criteria: * current uncontrolled and/or clinically significant medical condition. * primary progressive multiple sclerosis. * history of seizures or epilepsy. * other central nervous system disease or significant brain trauma. * bacterial or viral infection within the prior 30 days. * prior treatment with total body irradiation, clemastine, bexarotene, or other experimental remyelinating agent. * recent suicide attempt or continued expressed suicidal ideation. * implanted devices, such as pacemakers, cochlear prosthesis, neuro-stimulators. * abnormal ear anatomy or ear infection. * pregnancy, lactation, or lack of use of contraception. * unable to walk 25 feet continuously * other significant disease or disorder that might impair study participation. participants will be allowed to initiate or maintain background disease modifying therapy to reduce the risk of multiple sclerosis relapse and optimize recruitment.
gla:d back canada - a program for chronic and persistent low back pain

Conditions: Low Back Pain

Summary: gla:d back is a program developed in denmark to help people with persistent low back pain. this study will assist in contextualizing danish content into an english version of the program.

gla:d back is a program developed in denmark to help people with persistent low back pain. unfortunately, all materials developed for the program are in danish. in this pilot, the investigators will translate the danish materials into english, then use them to conduct an english training session for community clinicians in edmonton, alberta, canada. interested clinicians will then implement the program in their communities and provide feedback to contextualize the program for use in english. specifically, surveys, interviews and focus groups will be used to help fine-tune the printed content of the course (e.g. manuals), it's training materials (e.g. lectures) and processes related to redcap data collection (e.g. surveys).

Eligibility criteria:
inclusion criteria: * patients must have persistent low back pain of at least 1 month's duration. exclusion criteria: * participating currently in a supervised exercise or rehabilitation program or enrolled in another interventional clinical trial. * patients with nerve root involvement, suspected serious pathology, unstable trauma to the spine, aspects of pregnancy or other conditions that would prevent participation or disallow trial completion within the prescribed time period. * persons with conditions that require a specialist consult are suspected of needing a specialist consult, or have conditions that would be aggravated or worsened if treated by the interventions in this study.

Keywords: low back pain
double-blind trial of a probiotic supplement to reduce the symptoms of schizophrenia

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: the investigators intend to explore the hypothesis that symptoms of schizophrenia may be reduced by the administration of a probiotic supplement when used in addition to standard antipsychotic medications.

the primary aim of the current study is: 1. to evaluate the safety and efficacy of a supplemental probiotic therapy, containing the microorganisms lactobacillus rhamnosus gg and bifidobacterium lanimalis subsp. lactis (bb12), for individuals with schizophrenia who have residual psychotic symptoms of at least moderate severity. secondary aims of the study are: 2. to assess the effect of probiotic treatment on patients' gastrointestinal functioning 3. to study the effect of probiotic treatment in lowering the levels of antibodies to casein and gliadin. 4. to investigate the association between the efficacy of probiotic therapy and initial levels of antibodies to gliadin and casein.

Eligibility criteria:
inclusion criteria: * age 18-65. * capacity for written informed consent. * primary axis i diagnosis (dsm-iv) of schizophrenia, any type, or schizoaffective disorder (apa, 1994). * currently an outpatient at the time of enrollment. * residual psychotic symptoms which are at least moderately severe as evidenced by one or more panss positive symptom scores, and/or panss negative symptom scores of 4 or more; or a total panss score of 50 or more, containing at least three positive or negative items with scores of 3 or more at screening. * conformance to port treatment recommendation re maintenance antipsychotic medication dose (buchanan et al., 2010). * receiving antipsychotic medication for at least 8 weeks prior to starting the study with no medication changes within the previous 21 days. * proficient in the english language. exclusion criteria: * diagnosis of mental retardation. * any clinically significant or unstable medical disorder as determined by the investigators, including congestive heart failure, abnormal liver function or disease, renal failure, acute pancreatitis, any diagnosis of cancer undergoing active treatment, hiv infection or other immunodeficiency condition. * history of iv drug use. * primary diagnosis of substance abuse or dependence according to dsm-iv criteria within the last three months. * participated in any investigational drug trial in the past 30 days. * pregnant or planning to become pregnant during the study period. * receipt of antibiotic medication within the previous 14 days (as anaerobic organisms residing in the gastrointestinal tract may be minimally affected by antibiotics). * documented celiac disease (as such persons should be on a gluten-free diet as this is the standard care). * of note, the investigators are not limiting the study to individuals with elevated levels of gliadin or casein antibodies as the investigators intend to look at these levels as a predictor of response.

Keywords: schizophrenia schizoaffective probiotic supplements gliadin casein
predictive ability of different frailty indices for postoperative infections in elderly patients

Conditions: Postoperative Infections; Frailty

Summary: in this study, we extracted data from the patients medical record within the cohort to compare five existing frailty indices: the 5-item modified frailty index (mfi-5), the electronic frailty index (efi), the frailty index based on comprehensive geriatric assessment (fi-cga), the frailty risk assessment instrument for the elderly based on laboratory and clinical indicators (frail), and the hospital frailty risk score (hfrs). the study aims to evaluate the predictive values of each electronic frailty index for the incidence of postoperative infection-related adverse events. this includes the primary outcome of infection events occurring within 30 days and the secondary outcome of the correlations among the five frailty indices.


Eligibility criteria:
inclusion criteria: 1. aged 65 and above 2. patients who underwent non-cardiac surgeries and anesthesia exclusion criteria: 1. patients who underwent surgery within 30 days before the current procedure; 2. patients with missing baseline demographic data; 3. patients with incomplete medical records that resulted in the inability to fully assess all five frailty indices; 4. patients with missing data related to primary and secondary outcomes after surgery.

Keywords: frailty postoperative infection elderly patients
epicutaneous testing of cosmetics for skin compatibility

Conditions: Dermatitis

Summary: the dermatological testing of cosmetic products which are new on the market, or existing products with novel formulations is common and a useful procedure, yet necessary to alleviate common irritants and contact allergic reactions. cosmetic products contain a range of substances that may be considered as potential irritants or contact allergens. in order to estimate that risk, cosmetics are tested by applying patch tests.

the dermatological testing of cosmetic products which are new on the market, or existing products with novel formulations is common and a useful procedure, yet necessary to alleviate common irritants and contact allergic reactions. cosmetic products contain a range of substances that may be considered as potential irritants or contact allergens. in order to estimate that risk, cosmetics are tested by applying patch tests, as with allergic reactions.

Eligibility criteria:
inclusion criteria: * men and women older than 18 years old * persons undergoing a diagnostic patch test for reason of a skin disease * signed written informed consent exclusion criteria: * acute skin inflammation and eczema on the back * systemic corticosteroid and immunosuppressive therapy as well as uv exposure of the back within the last 4 weeks * topical corticosteroids used on the back within the last two weeks