Kornimate/medical-research-clean huggingface dataset:
effects of immulina tm supplements with pasc patients

Conditions: Post Acute COVID-19 Syndrome

Summary: this is a multi-site study that will try to determine the effects of immulina ™, a natural dietary supplement, on blood chemicals associated with inflammation that are often increased in patients with long covid (also called pasc).

this is a randomized, double-blind placebo controlled pilot study designed to determine effect size on altering blood inflammatory biomarkers and anti sars-cov-2-specific adaptive response including memory t cell, memory b cells and antiviral antibody titers. the participants will have a variety of clinical manifestations that will include varying degrees of fatigue, cognitive dysfunction and other pasc-related symptoms. individuals will be randomized by site to receive either immulina or placebo given daily for 8 weeks followed by a 4 week observation off supplement.

Eligibility criteria:
inclusion criteria: * males and females, 18 to 99 years old * if female of child bearing potential, using acceptable means of birth control or postmenopausal for at least two years * body temperature between 36.1°c and 37.7°c. * has completed the 4-week washout period (if applicable), i.e., has refrained from using internally-consumed dietary supplements prior to study day 1 and through the completion of the study * a minimum of 2 hours fasting (except water) prior to all of the blood draws * willing and able (in the opinion of study staff) to comply with all study requirements, including swallowing size 4 capsules (approximately 0.5" long and 0.25" diameter) and having phlebotomy * good written and verbal english skills; able to follow instructions (in the investigator's opinion) * not participating in a clinical study, currently or within the last 30 days * signed informed consent exclusion criteria: * pregnant or lactating * digestive tract disorders or conditions, such as (but are not limited to): ulcers, ulcerative colitis, crohn's disease, gastric bypass, colostomy, ischemic colitis, gastroesophageal reflux disease (gerd), irritable bowel disease (ibd), diverticulitis that would be expected to impact on the oral disposition of the immulina dietary supplement * existence of any surgical and/or medical condition, significant disease or disorder, or any finding that may, in the judgment of the investigator, put the volunteer at risk or compromise study participation. * any blood-thinning or clotting concomitant medication (prescription anticoagulants) * donation or loss of 400 ml or more of blood within 8 weeks of study day 1 or unwilling to abstain from donation of blood during the study * known or suspected allergy or sensitivity to immulina, cellulose * history of drug or alcohol abuse within the last 12 months

Keywords: immulina post acute covid-19 syndrome inflammation natural dietary supplement
association of platelet parameters with bleeding severity in children with itp

Conditions: Immune Thrombocytopenia

Summary: patients with severe immune thrombocytopenia (itp) present with similarly low platelet counts but varying bleeding symptoms, making it difficult to predict the disease course and to decide on an appropriate treatment plan. in a single-center study, platelet parameters including the immature platelet fraction, the absolute immature platelet count , and functional response markers were found to be significantly associated with patient bleeding severity, independent of platelet count. this study aims to confirm and replicate these findings in a multi-center patient population and to investigate the use of these parameters to better predict disease severity and bleeding events.

many children with severe immune thrombocytopenia (itp) present with mild symptoms and their disease spontaneously resolves within 3 to 6 months. however, a subset of pediatric itp patients experience severe bleeds and their symptoms persist for more than 6 to 12 months. both patient populations present with similarly low platelet counts, making it difficult to predict the disease course and to decide on a treatment plan. the current american society of hematology treatment guidelines advise that most cases of itp may be managed through close observation, while pharmacological interventions that may result in treatment-related toxicities may be used in patients with more severe bleeding symptoms. in order to improve the care and management of pediatric patients with itp, it is necessary to develop a better predictor of bleeding events and disease severity than the patient's platelet count. in a previous single-center study, investigators studied the association of different platelet parameters with patient bleeding severity. using whole blood from patients diagnosed with severe itp, investigators measured the immature platelet fraction (ipf) and absolute immature platelet count (ipc) through a hematology analyzer (sysmex xn-1000). investigators performed functional tests on the platelets and analyzed them through flow cytometry. in this study, the investigators found that the ipf and ipc is associated with patient bleeding severity, independent of platelet count. it was also determined that functional activation markers such as p-selectin and glycoprotein (gp) iib-iiia are significantly associated with subsequent bleeding severity in children, independent of platelet count. the results of these proposed studies in itp patients may suggest clinically relevant uses of these assays. to confirm these findings, this trial will repeat the previous study in a multi-center patient population, including a greater number of patients with severe bleeding and low platelet counts.

Eligibility criteria:
inclusion criteria: * diagnosed with primary or secondary immune thrombocytopenia. * platelet count of \< 50 x 10\^9/l exclusion criteria: * may not have received aspirin 10 days prior to study entry. * may not have received nonsteroidal anti-inflammatory drugs (nsaids) 3 days prior to study entry.

Keywords: itp platelet function sysmex
utilization of leukocyte esterase in the diagnosis of pediatric joint infections

Conditions: Joint Infection; Septic Arthritis

Summary: pediatric joint infections are a common diagnostic dilemma encountered by treating orthopaedic surgeons. no single test is sensitive or specific enough to stand alone in determining the presence of joint infection. the purpose of this study is to test the usefulness of a chemical test strip to detect infection in fluid that is removed from a joint (intra-articular aspiration) in pediatric patients. the test strip measures an enzyme called leukocyte esterase, which has been shown to be useful in detecting the presence of infection in fluids from other parts of the body. this study will assess the efficacy of the leukocyte esterase test as a diagnostic tool for evaluating pediatric joint infections. the hypothesis of the study is that a positive leukocyte esterase test identifies a septic joint in pediatric patients undergoing intraoperative joint aspiration.

pediatric patients requiring an intra-articular joint aspiration for suspected infection or for other reasons will have a leukocyte esterase test performed on fluid removed from the joint. a convenience sample of consecutive patients will be screened according to inclusion/exclusion criteria and enrolled in the study by informed consent. all patients who will be screened for the study will have already been identified as needing an intra-articular joint aspiration in accordance with standard of care. all patients who are enrolled in the study will have the leukocyte esterase test performed on the fluid that is aspirated. results of the test strip will be recorded.

Eligibility criteria:
inclusion criteria: * all patients at this facility over the age of 3 months and below the age of 18 years who receive an intra-articular aspiration exclusion criteria: * immunocompromised patients * renal failure patients * patients younger than 3 months old * patients 18 years of age or older * volume of aspirate is less than 1.5 ml
chemsex engagement and hiv biomedical prevention in msm

Conditions: Recreational Drug Use

Summary: hiv biomedical prevention through treatment-as-prevention (tasp) and pre-exposure prophylaxis (prep) is highly efficacious for reducing hiv transmission risk. the benefits could be undermined by the rising hiv transmission risks in men who have sex with men (msm) who engaged in chemsex. this project aims to assess the impacts of chemsex on the growth of the hiv epidemic by exploring the complex relationships between chemsex engagement and usage of hiv biomedical prevention in msm in hong kong. participants would be recruited from the community and clinics in 2 cross-sectional studies (500 hiv-negative and 500 hiv-positive msm), for hiv self-testing and completing an electronic questionnaire. the association of chemsex would be examined between prep-naïve and prep experienced hiv-negative msm, and between good and poor adherence to antiretroviral therapy (art) among hiv-positive subjects in case-control analyses using logistic regression and multilevel models. the main outcomes include coverage of biomedical prevention in msm, and their drug use patterns.


Eligibility criteria:
inclusion criteria: * aged 18 or above * male * have had sex with men since 2019 * could be communicated in english or chinese exclusion criteria: * failed to provide consent

Keywords: chemsex engagement pre-exposure prophylaxis antiretroviral therapy men who have sex with men
per-oral endoscopic myotomy (p.o.e.m.) for treatment of esophageal motility disorders

Conditions: Achalasia; Hypertensive LES

Summary: spastic esophageal motility disorders induced significant symptoms including dysphagia, retrosternal pain and regurgitation. per oral endoscopic myotomy (p.o.e.m.) is a novel approach to perform myotomy through the esophagus with long submucosal tunnel. this study aimed to investigate the feasibility and safety of p.o.e.m. and translate the techniques from animal study to clinical practice in human.


Eligibility criteria:
inclusion criteria: * all patients with age ranged 18 to 80 who had primary esophageal motility disorders will be recruited. the primary motility disorders included: achalasia, hypertensive les, nutcracker esophagus and diffuse esophageal spasm. exclusion criteria: * patients will be excluded from this study with the followings - 1. pregnancy 2. informed consent not available 3. previous history of esophagectomy or mediastinal surgery 4. previous history of endoscopic resection for early esophageal cancers, including endoscopic mucosal resection and endoscopic submucosal dissection 5. end-stage achalasia with dilated esophagus more than 6cm on barium swallow

Keywords: achalasia, hypertensive les
folate and protection against cervical cancer

Conditions: Cervical Cancer

Summary: this is a randomised double-blind placebo-controlled trial to see whether giving a low dose of the vitamins folic acid and riboflavin is beneficial to women who have very low grade abnormalities of the cervical cells.

the overall aim of the study is to evaluate interactions between intakes of folic acid and riboflavin with a common polymorphism relevant to folate metabolism, in determining the risk of cervical cancer in women who carry high risk human papillomavirus. we will test the following hypotheses: supplements of riboflavin and folic acid will increase the rate of regression of low grade cervical intra epithelial neoplasia (cin1). effects of supplemental folic acid and riboflavin on cin1 regression are modulated by a common polymorphism in the mthfrc677t gene. we will recruit women with biopsy-proven cin1 and carrying high risk hpv infection, and randomise to a 12month intervention of 1.2mg folic acid and 5mg riboflavin or placebo. the primary outcome will be regression of biopsy-proven cin1, and secondary outcomes will include measures of dna stability.

Eligibility criteria:
inclusion criteria: * biopsy-diagnosed cin1 infection with oncogenic hpv exclusion criteria: any other stage of cervical abnormality pregnant or planning a pregnancy diabetic taking b vitamin supplements taking anti-epileptic treatment taking methotrexate bleeding after intercourse abnormal gi function infection with chlamydia, hiv or other agent

Keywords: randomised placebo controlled intervention trial folic acid riboflavin cervical cancer
mindful melody: feasibility of implementing music listening on an inpatient psychiatric unit and its relation to the use of as needed medications for acute agitation

Conditions: Agitated; State, Acute Reaction to Stress; Agitation,Psychomotor

Summary: in this quality improvement project, our objectives were to assess the feasibility and effectiveness of using music as an adjunct to or replacement of pharmacological interventions for patient agitation on an inpatient psychiatric unit. we hypothesized that music availability would help to reduce agitation and reduce the amount of as-needed medications used for cases of patient agitation.

the number of as-needed medications for agitation was quantified during a three month period during which patients had the option of listening to music in cases of agitation. this was compared to the number of medications needed for agitation during another 3 month period during which music was not available. the medications used were quantified using pharmacy records. patients and nurses were surveyed to determine how effective and feasible they thought the music intervention was. the study was conducted at the suny upstate university hospital inpatient psychiatric unit, which is a 24-bed unit. 172 patients were included in the project. before starting to offer music, a basic training meeting was held with nursing staff to understand the purpose of the project. patients participating had the option of selecting a preferred musical genre and they listened to music using wireless headphones. the playlists used were genre playlists automatically generated by spotify music application. if patients did not like the song that was generated, they had an option to skip the song using their bluetooth headphone controls. headphones were collected after 30 minutes of listening unless they were return prior to completion of the listening session.

Eligibility criteria:
inclusion criteria: * any patient 18 years or older admitted to the inpatient psychiatric unit exclusion criteria: * patients who did not want to listen to music or be included in the project were excluded

Keywords: agitation music inpatient
acupuncture for stress-predominant mixed urinary incontinence

Conditions: Mixed Urinary Incontinence

Summary: the investigators plan to conduct this multi-center, three-armed, randomized controlled trial to evaluate the efficacy of electroacupuncture (ea), compared with sham electroacupuncture (sa) and waiting list (wl) on participants with stress-predominant mixed urinary incontinence (mui).

mui tends to present with more severe symptoms and put greater burden on the health of individual and economy of society. current european association of urology (eau) guideline on incontinence recommends to initiate treatment targeted at predominant component of mui. however, as to whether the interventions for stress urinary incontinence (sui) can be effectively generalized to stress-predominant mui, there is still no powerful evidence to support it. it is necessary to seek for interventions specific to stress-predominant mui. results of previous studies indicated that acupuncture might help to relieve the incontinence symptoms.

Eligibility criteria:
inclusion criteria: 1. diagnosis of mui by the coexistence of sui and urgency urinary incontinence (uui) symptoms in accordance with eau guideline; 2. female participants aged between 35 and 75; 3. stress index \> urge index in accordance with medical, epidemiologic, and social aspects of aging(mesa) questionnaire； 4. symptoms of mui for at least three months, and stress ief outnumber 50% total ief documented in 3-day voiding diary; 5. less than 12 micturition episodes in average 24 hours documented in 3-day voiding diary; 6. positive cough stress test; 7. urine leakage \> 1 g in 1-hour pad test; 8. voluntary participation in the trial and signed written informed content. exclusion criteria: 1. urgency-predominant mui, pure sui, pure uui, overflow urinary incontinence (ui) and neurogenic bladder; 2. uncontrolled symptomatic urinary tack infection; 3. tumor in urinary system and pelvic organ; 4. pelvic organ prolapse ≥ degree ⅱ； 5. residual urine volume ≥ 100ml； 6. history of treatments targeted at ui, such as acupuncture, pfmt and medications in the previous one month; 7. history of surgery targeted at ui or in pelvic floor, including hysterectomy; 8. uncontrolled diabetes or severe high blood pressure; 9. nervous system diseases that may hamper the function of urinary system, such as multiple sclerosis, alzheimer's disease, parkinson's disease, spinal cord injury, cauda equina nerve injury, or multiple system atrophy; 10. severe heart, lung, brain, liver, kidney, mental illness, coagulation dysfunction or with obvious cognitive dysfunction 11. installed cardiac pacemaker; 12. inconvenient or unable to walk, run, go up and down stairs; 13. allergy to metal, severely fear of acupuncture needles or unbearable to ea; 14. pregnant at present, plan to conceive in future one year, at lactation period or within 12 months after childbirth.

Keywords: acupuncture stress-predominant mixed urinary incontinence
prospective study to validate the diagnostic performance of ivd capsule covid-19-np test for the detection of sars-cov-2

Conditions: COVID-19; COVID-19 Pandemic

Summary: the purpose of the study is to conduct a prospective evaluation of the diagnostic performance of the ivd capsule covid-19-np test for antigenic determination of sars-cov-2 virus on the abioscope® instrument. the objective of the clinical study is to demonstrate that the ivd capsule covid-19-np test: 1. shows sensitivity: * ≥ 80% when testing unselected symptomatic participants within the first seven days of symptom onset or asymptomatic participants when diagnosis is confirmed by rt-pcr; or * ≥ 90% for subjects with ct ≤ 25. 2. show ≥ 98% specificity.


Eligibility criteria:
inclusion criteria: * provide valid informed consent before taking the tests; * in the case of symptomatic patients, be tested within the first seven days after the onset of symptoms. * male or female, aged equal to or older than 18 years of age. exclusion criteria: * symptomatic participants who take the test after seven days after the onset of symptoms are excluded from the study
a group intervention for promoting health-related habits (lev-g)

Conditions: Life Style; Health-Related Behavior; Disabilities Mental; Disability Physical; Acceptability of Health Care

Summary: health-related habits influences mental and physical health. still, treatment of health-related habits, which can help to remedy health problems, is often not done at all or very superficially. multiple guidelines emphasize the importance of prioritizing health-related habits, but there is a lack of implemented models. to solve this, the investigators have developed a transdiagnostic, interprofessional material intended for several care settings. the lev-g intervention is intended for groups. there is also an individual version of lev that has its on registration in clinical trails.

lev is a brief, transdiagnostic, interprofessional intervention targeting health-related habits that is intended for several care settings. the main population intended is individuals with neurodevelopmental disorders or parents or close relations to children with disabilities. this study will therefore be open for participants recruited from several types of healthcare services in sweden. study 1: the feasibility trial investigates the following questions: completion: how many participants that started lev completed the intervention? what were the reasons for not not completing lev? how many sessions did the participants complete? lev includes screening (lev-s), three sessions + one booster session. level of acceptability: was lev perceived as creditable and satisfactory by healthcare workers and participants? treatment credibility will be measured before lev and after the last session for both participants and healthcare workers. treatment satisfaction will be evaluated after each session and after the intervention is completed. session evaluations will be done by both participants and healthcare workers. do the intervention lead to adverse events? to what extent were individual goals met?

Eligibility criteria:
inclusion criteria: * both adults with and without disabilities recruited from different healthcare contexts. exclusion criteria: * intellectual disability of the degree where the participant is not able to follow the protocol in lev. * insufficient command of the swedish language/ unable to understand the content. * severe psychiatric comorbidity that makes participation difficult (e.g. severe depression, severe suicidality, severe anxiety, ongoing psychosis, manic episode), other circumstances that could make participation hard (e.g. homelessness).
effect of metformin on exercise-induced lipolysis

Conditions: Diabetes Mellitus, Type 2

Summary: the aim of this study is to investigate whether metformin has inhibitory effect on exercise-induced lipolysis in subcutaneous adipose tissue in healthy lean man. ten healthy lean mean will follow protocols consisting of 60 minutes of exercise on bicycle ergometer combined with a) orally administered metformin and b) locally administered metformin into adipose tissue and c) without metformin treatment. microdialysis is used for assessment of metabolites in situ in subcutaneous adipose tissue.

metformin and physical activity are often recommended as the first therapeutic agents to improve glycemic control for prediabetes and type 2 diabetes (ada). it has been reported that metformin decrease plasma concentration of non-esterified fatty acids in patients with type 2 diabetes which might be associated with the inhibition of lipolysis in adipose tissue. however, the inhibition of lipolysis during physical exercise, would not be probably beneficial. thus, the effect of metformin on lipolysis during exercise is investigated in this protocol. as the lipolysis regulation is often impaired in obese and diabetic patients, the healthy lean men were chosen for this pilot study. glycerol will be analyzed as a measure of lipolytic rate in adipose tissue and in plasma. lactate levels will be observed. our findings should provide a new background about the combination of physical activity and metformin medication.

Eligibility criteria:
inclusion criteria: * healthy lean men, non obese, bmi 20-28 kg/m2 exclusion criteria: * weight change within the 3 months before the study, * hypertension, * impaired fasting glucose * diabetes * hyperlipidemia * drug or alcohol abuse * smoking

Keywords: lipolysis adipose tissue exercise