Kornimate/medical-research-clean huggingface dataset:
impact of three-dimensional visualization on operation strategy and complications for pancreatic cancer

Conditions: Pancreatic Cancer

Summary: the aim of the multi-centre study is to evaluate correctly the impact of three dimensional visualization on operation strategy and complications for pancreatic cancer.

because of the complexity of pancreatic cancer, the limitations of 2d images of ct/mri and the uncertainty of surgeons'experience, it is difficult for the surgeons to diagnosis and assess the operation strategy accurately based on traditional 2d imaging(ct/mri).the aim of the multi-centre study is to evaluate correctly the impact of three-dimensional visualization on operation strategy and complications for pancreatic cancer.

Eligibility criteria:
inclusion criteria: 1.18 years≤ age ≤70 years 2.compling with the diagnosis criteria of pancreatic cancer. 3.primary pancreatic cancer without metastasis. 4.the patients are volunteered for the study. exclusion criteria: 1. patients with mental illness. 2. patients can't tolerate the operation owe to a variety of basic diseases (such as severe cardiopulmonary insufficiency, renal insufficiency, cachexia and blood system diseases, etc.) 3. the patients refused to take part in the study. 4. there are other co-existed malignant tumors.

Keywords: pancreatic cancer three-dimensional visualization
titanium fusion implant in combination with trans-iliac screws for insufficiency fractures of the pelvis

Conditions: Pelvic Fracture; Insufficiency Fractures; Mobility Limitation

Summary: many approaches to the surgical treatment of of-p have been tried, but no one method has stood out as particularly successful. the placement of three implants, including implants that could minimise motion in the sacroiliac joint through early fixation and long-term fusion of the sacroiliac joint, can prevent micromotion in the fracture and thereby improve the clinical outcome of of-ps. the ifuse-3d implant was shown to be safe and effective for chronic sacroiliac pain in non-osteoporotic patients. the primary aim is to assess the proportion of patients operated on using ifuse-3d in conjunction with transiliac-transsacral screws who regain pre-fracture mobility by the time of hospital discharge.


Eligibility criteria:
inclusion criteria: * legal capacity, capacity to inform * presence of a written declaration of consent by the patient * age: ≥ 60 years * acute or subacute (less than 2 months) posterior pelvic girdle pain associated with low energy trauma or occurring spontaneously * diagnosis confirmed by ct and/or mri * the fracture corresponds to types of3 and of4 of the of pelvis classification. * prior to the fracture, there was free, non-wheelchair mobility (functional mobility score of 2 or higher) exclusion criteria: * diagnosed uncontrolled psychiatric illness (e.g. dementia, schizophrenia, major depression, personality disorder) that could affect study participation or reporting of findings * history of pelvic fracture within one year with evidence of failure of fracture to heal or internal fixation of the pelvic ring of any type * patients unable to ambulate before the fracture * patient has had lumbar instrumentation of more than two vertebrae and/or instrumentation of s1 in the past * additional fractures that limit mobility * of-p associated with benign or malignant tumours of the pelvis * abnormal neurological condition that could affect study participation * an unusual clinical condition associated with a high risk of not being able to follow up (e.g. copd, severe heart failure, parkinson's disease, autoimmune diseases) * any pelvic condition or anatomical feature that makes surgery impracticable * known allergy to titanium or titanium alloys * known opioid abuse for chronic pain syndromes * participation in other interventional trials * lack of surgical capability * persons in a dependent/employee relationship with the sponsor or investigator * placement in an institution due to court or administrative order.

Keywords: fracture fixation fragility fractures pelvis surgical procedures minimal invasive
an open label safety study of tipranavir co-administered with low-dose ritonavir in patients with advanced hiv-1 infection and limited treatment options.

Conditions: HIV Infections

Summary: the purpose of this open label safety study is to provide access to and evaluate the safety and tolerability of tpv/r in treatment-experienced patients with advanced hiv-1 infection who have failed at least two pi-containing regimens, and have limited treatment options.


Eligibility criteria:
inclusion criteria: 1. triple anti-retroviral class experienced patients with at least 2 previous pi-based regimens who had failed or are intolerant to currently approved hiv-1 treatments. 2. age equal or more than 18 years 3. patient is willing to use an effective barrier method of contraception for the duration of study participation and up to three months thereafter 4. patient voluntarily provides written informed consent to participate, in compliance with local law. exclusion criteria: 1. hypersensitivity to active ingredients or any of the excipients in tipranavir or ritonavir 2. required use of restricted medications. 3. female patients of childbearing potential who have a positive pregnancy test at baseline or are breast feeding. 4. any medical condition which in the opinion of the investigator would interfere with the patients' ability to participate in or adhere to the requirements of this protocol. 5. use of other investigational drugs, within 30 days prior to tpv boosted with ritonavir initiation and for the duration of study participation 6. hepatic impairment evidenced by the following baseline laboratory findings: * ast or alt more than 5x uln or total bilirubin more than 3.5x uln * ast or alt more 2.5x uln and total bilirubin more 2x uln
analysis of tu-less by 3d laparoscopy in the treatment of infertility

Conditions: Infertility, Female

Summary: this study intends to carry out a prospective, randomized controlled trial to compare the trans-umbilical laparoendoscopic single-site surgery by 3d laparoscopy with normal laparoendoscopic surgery in the treatment of infertility patient, so as to further clarify the safety and curative effect of tu-less by 3d laparoscopy and provide evidence-based basis for its application in infertility population.


Eligibility criteria:
inclusion criteria: 1. patients are younger than 36 and older than 24. 2. clearly diagnosed with female infertility. 3. infertility within 1 to 10 years. 4. informed consent form signed exclusion criteria: 1. over the age of 35. 2. indefinite diagnosis. 3. with severe medical problems (severe liver disease, kidney disease, respiratory diseases, heart disease or uncontrolled diabetes, epilepsy, etc., dysfunction of important organs). 4. abdominal surgery history 5. unwilling to comply with the research plan.

Keywords: infertility, tu-less, 3d laparoscopy
the impact of family financial support on health related quality of life

Conditions: Quality of Life; Socioeconomic Status

Summary: the investigators have partnered with financial coaching organizations to establish what the investigators have termed a "medical-financial partnership (mfp)" that offers financial coaching to improve financial and mental health. the investigators will evaluate the mfp's impact on health related quality of life using the patient reported outcome measurement information system (promis) 10 global short form.

financial coaching is a new tool in the field of community development, but it has already demonstrated significant financial impact in a number of studies, including one randomized trial conducted by the urban institute. financial coaching improves participant financial literacy, budgeting, saving for financial emergencies, and debt level. the investigators' project will help clinicians and the field of community economic development understand health and well-being through a new economic lens and assess the health-related impacts of the emerging field of financial coaching. the investigators have partnered with financial coaching organizations to establish what they have termed a "medical-financial partnership (mfp)" that offers financial coaching to improve financial and mental health. the investigators will evaluate the mfp's impact on health related quality of life using the patient reported outcome measurement information system (promis)10 global short form. community-based participants will be recruited from south los angeles and randomized to receive either monthly financial coaching plus access to referral for social services (intervention) or access to referral for social services alone (control). inclusion criteria include having dependents under age 18, having some form of income, and having a tax identification number (social security number or individual tax identification number). participants will be surveyed quarterly regarding their health related quality of life using the promis-10 global short form.

Eligibility criteria:
inclusion criteria: * participants must be caregivers/parents with one or more child dependents, some form of income, and a tax identification number. exclusion criteria: * inability to participate in financial coaching due to activity/cognitive limitations or primary language other than english or spanish.

Keywords: health related quality of life financial coaching medical financial partnership social determinants of health socioeconomic status
pecs block vs local infiltration in mastectomy

Conditions: Pain, Postoperative

Summary: studied the comparison between pecs ii block and lia on pain intensity, opioid requirements, rnl, and postoperative il-6 levels in mrm patients.


Eligibility criteria:
inclusion criteria: 1. age: 18-60 years old. 2. body weight (bw): 50-70 kg. 3. height (tb): 150-170 cm. 4. body mass index (bmi): 18.5-29.9 kg/m2. 5. american society of anesthesiologists physical status (asa ps) class i-ii. 6. patients undergoing elective mrm surgery under general anesthesia. exclusion criteria: 1. patients with contraindications to pecs ii block. 2. patients with contraindications to lia. 3. patients with coagulation disorders or receiving anticoagulant therapy. 4. patients with a history of chronic pain. 5. patients with a history of allergy to study materials. 6. patients with a history of previous breast surgery. 7. patient refuses to participate in the study.

Keywords: postoperative pain modified radical mastectomy peripheral nerve block local infiltration anesthesia pectoralis nerve block
voice biomarkers predictive of depression and anxiety

Conditions: Depression, Anxiety; Healthy; Mental Health Wellness 1

Summary: the objective of this study is to collect data to improve the sensitivity and specificity of kintsugi voice's (formerly kivatm) predictions on audio files. a web-based audio recording tool will be used to record voice sample and ask participants the phq-9 and gad-7 questions. a voluntary subset of participants will then be assessed by mental health professionals with the hamilton depression rating scale (ham-d) and hamilton anxiety rating scale (ham-a) scores.

participants will be recruited via various online mediums to participate in a voluntary observational study. completing the consent and survey on their smart-phone, tablet, or computer, the participant will be asked to provide a 1-minute response to an audio prompt "how was your day?" after recording their response, the participant will be asked to complete the patient health questionnaire-9 and generalized anxiety disorder-7 measures independently. in a second voluntary phase of the study, participants who indicated a score higher than 20, will be contacted by the research team via email to determine if they are interested in a voluntary follow-up to their initial study participation. participants who would like to take part in the additional survey will complete additional voice recording responses to prompts and complete the patient history questionnaire and generalized anxiety disorder-7. these participants will be contacted by a mental health professional to discuss seeking mental health resources and clinicians, as well as, complete the hamilton depression rating scale and hamilton anxiety rating scale via the telephone.

Eligibility criteria:
inclusion criteria: * adult males and or females over the age of 18 at the time of informed consent. adults with a known history of depression and/or anxiety and adults without a known history of depression and/or anxiety will be included in this study. * access to a laptop, smart-phone or tablet with a functioning microphone * stated willingness to comply with all study procedures and availability for the duration of the study * fluency in english exclusion criteria: * visual impairment that would make it difficult for the participant to see the web-based survey * motor impairment that would make it difficult for the participant to use the web-based survey

Keywords: mental health depression anxiety artificial intelligence
accuracy of cardiac acoustic biomarkers recorded by the wearable cardioverter defibrillator

Conditions: Heart Failure

Summary: evaluate data accuracy of cardiac acoustic biomarkers (cabs) recorded by the wearable cardioverter defibrillator (wcd) as compared to the audicor am acoustic cardiography recorder.

single arm, prospective, non significant risk device study to evaluate data accuracy of cardiac acoustic biomarkers (cabs) recorded by the wearable cardioverter defibrillator (wcd) compared with the cabs data simultaneously recorded by an acoustic cardiography recorder, the audicor am device.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * heart failure or a history of heart failure * ischemic or non-ischemic cardiomyopathy * ejection fraction less than or equal to 40% as measured within the last 6 months exclusion criteria: * implanted left ventricular assist device * pacemaker dependency * currently hospitalized * atrial fibrillation on their last ecg or having an irregularly irregular pulse
wgs-guided tracking and infection control measures of crkp

Conditions: Klebsiella Pneumoniae Infection

Summary: the objective of this study is to investigate the effect of the infection control measures based on the active screening of carbapenem-resistant klebsiella pneumoniae and whole-genome based tracking and surveillance though the hospital.


Eligibility criteria:
inclusion criteria: 1. the patient was admitted to the icu of neurosurgery in the west hospital of huashan hospital affiliated to fudan university from september 2019 to september 2021, or transferred from the icu of another hospital 2. the patient is more than 18 years old and less than 80 years old, regardless of gender. 3. informed consent of the patient; exclusion criteria: 1. patients participating in other clinical trials at the same time 2. pregnant 4. people who will affect the outcome of the study: whose specimens could not be received or not enough for testing
myocardial and renal dysfunction by oxidative stress caused by cardiac surgery

Conditions: Reperfusion Injury

Summary: assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtdna, ndna, carbonilated proteins, nitrotyrosine, oxy-ldl, s100b-protein.


Eligibility criteria:
inclusion criteria: * shedduled cabg exclusion criteria: * stroke befor surgery * miocardial infarction 6 monthes befor surgery * dementia * liver cirrhosis
the effect of breathing helium-hyperoxia during pulmonary rehabilitation in patients with copd

Conditions: Chronic Obstructive Pulmonary Disease; COPD; Emphysema; Lung Diseases; Bronchitis, Chronic

Summary: the purpose of this study is to examine whether breathing helium-hyperoxia during exercise in a pulmonary rehabilitation program can improve the exercise tolerance and health related quality of life of patients with chronic obstructive pulmonary disease (copd).

it is well accepted that the exercise training as part of a comprehensive pulmonary rehabilitation program can improve exercise tolerance, functional status and quality of life in patients with copd. it is feasible that if patients were able to perform a greater volume or intensity of exercise during rehabilitation then the outcomes of the program would be improved. recent research has demonstrated that breathing a helium-hyperoxic gas mixture can significantly reduce dynamic hyperinflation and dyspnea during exercise in patients with copd and can increase exercise tolerance to a greater extent than breathing room air or a nitrogen-based hyperoxic gas. if patients with copd were to breathe a helium-hyperoxic gas during exercise they should be able to tolerate a greater intensity of exercise while maintaining similar levels of exertional symptoms to those observed at lower exercise intensities breathing room air. as a result patients randomized to the helium-hyperoxia condition should obtain greater improvements in exercise tolerance than those receiving usual care (i.e. breathing room air) comparisons: standard pulmonary rehabilitation of patients with copd receiving either usual care (air breathing) or helium-hyperoxia (40% o2, 60% helium).

Eligibility criteria:
inclusion criteria: * fev1/fvc\<70% predicted; * fev1\<70% predicted; * rv\>140% predicted. exclusion criteria: * cardiovascular contraindications to exercise; * musculoskeletal abnormalities that limit exercise tolerance; * spo2\<85% during a constant work rate test; * on supplemental oxygen. * exacerbation within the last month

Keywords: exercise tolerance dyspnea rehabilitation helium
teleprep for at-risk youth in colorado

Conditions: Hiv

Summary: youth represent the largest proportion of new hiv infections in colorado, reflective of their inadequate access and uptake of pre-exposure prophylaxis(prep)for hiv prevention. colorado's 2019 hiv/aids prevention program state-wide review of prep barriers showed prep eligible individuals do not access prep services due to lack of interest, not wanting referral to a navigator, and low estimation of hiv risk. the overall goal is to provide youth at higher risk for hiv with an effective youth informed telemedicine delivery of prep (teleprep) that addresses prep barriers and contributes to ending the hiv epidemic in colorado. the primary objective will be proportion of youth retained on prep 12 months after initiation. the hypotheses are that a teleprep model for youth will be acceptable and feasible and will result in successful initiation, persistence and retention on oral prep.


Eligibility criteria:
inclusion criteria: * hiv negative * eligible for prep using emtricitabine (f)/tenofovir alafenamide (taf) (f/taf) (brand name descovy) based on current cdc guidance * assigned male at birth * has had male sex partners in the past 6 months (and not in a monogamous partnership with a recently tested, hiv-negative man) and * either any sex without a condom in the past 6 months or * a bacterial sexually transmitted infection * consents to teleprepvisits * willing to use current insurance coverage for clinic and laboratory services or willing to be assisted to obtain insurance coverage or eligible for other coverage such as title x funds or charity care exclusion criteria: * hiv-infection or concern for acute hiv infection until ruled out * pregnancy * persons at risk through receptive vaginal sex including cisgender women and transgender men (persons assigned female sex at birth) * persons with only injection drug indications for prep without sexual risk indications outlined in inclusion criteria

Keywords: youth telemedicine telehealth hiv prevention
multiple respiration-correlated cone beam computed tomography (ct) scans to reduce target positioning errors in radiotherapy treatment of thoracic cancer

Conditions: Esophageal Cancer; Lung Cancer

Summary: the purpose of this study is to use cone-beam ct scans to more accurately position the tumor during radiation and to see whether this method is more effective than the standard method of using 2d images (portal images), which is a type of x-ray. cone-beam ct is a type of ct scanner attached to the treatment accelerator that produces 3d images of the patient. the ability to eliminate the tumor with radiation depends in part on the accuracy of delivering the radiation to the lung. the position of the tumor changes because of normal breathing. therefore, we want to improve the accuracy of the way the radiation is delivered to the tumor. with cone-beam ct scans taken before and during your treatment, we will be able to determine the location of the tumor with 3d images, measure how much the tumor moves as you breathe, and then position you so that the tumor will get the best delivery of radiation.


Eligibility criteria:
inclusion criteria: * patients must have histologic proof of a thoracic malignancy, confirmed at mskcc and suitable for radiation therapy, in order to be eligible for this study. * patients must be older than 18 years of age * at least part of the tumor must be visible as observed in a diagnostic or planning ct. patients must have karnofsky performance status ≥ 70% exclusion criteria: * pregnant women

Keywords: lung esophageal cone beam ct scan
paraspinous anesthetic block for non-responsive pelvic pain

Conditions: Paraspinous Block; Pelvis Pain Chronic

Summary: this study examines randomized triple-blind clinical trial and the efficacy of paraspinous anesthetic block on the treatment of chronic pelvic pain in patients non-responsive to pharmacological management. sixty patients will be randomly divided and allocated into group intervention (paraspinous anesthetic block) and control (placebo procedure in subcutaneous tissue).

patients will be allocated into one of two groups (intervention or placebo), and will be submitted to the corresponding procedure (paraspinous anesthetic block or placebo puncture in subcutaneous tissue). in the first appointment, pain will be measured with the vas (visual analogue scale); quality of life and function basal level will be evaluated by scales sf-36 (medical outcome short-form (36)health survey)and fsfi (female sexual function index), in portuguese validated versions. procedure will be realized as planned for each group. second appointment will occur one week after the procedure, and vas scale will be applied. third appointment will occur in one month. vas scale will be applied again,and procedure will be repeated if patient does not have a reduction of at least 30% of pain. next consultations will occur at two months, three months, four months and five months, with application of vas scale to keep monitoring evolution of pain. at six months of study, vas scale will be applied along with sf-36 and fsfi questionnaires, to evaluate improvement in pain and in quality of life and function level.

Eligibility criteria:
inclusion criteria: * patients with benign pelvic pain non-responsive to pharmacological treatment, lasting at least 6 months, located in the anatomic pelvis, anterior abdominal wall, infra-umbilical region, lumbossacral region or buttocks. pain must be hard enough to cause functional impairment or to motivate medical counseling. the absence of physical findings does not decreases the importance of pain, nether excludes the possibility of pelvic pathology. exclusion criteria: * patients who do not want to take part in the study * age under 18 years old * pelvic pain lasting less than 6 months * relief or resolution of pain with pharmacological treatment * pain of neoplastic origin * known allergy or report of adverse reaction related to lidocaine

Keywords: paraspinous block non-responsive chronic pelvic pain