Kornimate/medical-research-clean huggingface dataset:
effects of probiotics supplementation on intestinal microbiome in malignancy pts(get pelvic/abdominal rtx)

Conditions: Cancer

Summary: the purpose of this study is to evaluate the effect of probiotics to improve the intestinal microbiome in malignancy patients who get pelvic/abdominal radiotherapy.

pelvic/abdominal radiotherapy carries a risk of complications. acute complications include diarrhea, abdominal pain, inflammatory change in the small intestine. radiation creates changes in bacterial microbiome, the vascular permeability of the mucosal cells and in intestinal motility. probiotics were known to improve gastrointestinal function. this is a randomized, double-blind, placebo-controlled study involving 26 patients designed to evaluate the effect of probiotics to change the intestinal microbiome in in patients undergoing concurrent pelvic/abdominal rt.

Eligibility criteria:
inclusion criteria: * patients who current diagnosis of gynecologic cancer or rectal cancer and never previously received radiation therapy and will use for the first time radiotherapy at department of radiation oncology, seoul national university hospital. * ecog performance status (ps) of 0, 1, or 2. * signed written informed consent. * patients who get pelvic/abdominal radiotherapy. exclusion criteria: * people who use antibiotics that can affect intestinal microorganism growth within one month before the study. * patients who use probiotics within one month before the study. * patients received neoadjuvant chemotherapy. * acute enteritis symptoms (diarrhea, abdominal pain, nausea, vomiting) for the patient. * patients diagnosed with inflammatory bowel disease. * patients suspected gastrointestinal infections and other infectious diseases. * suspected infections from blood tests : excessive rise in wbc, esr, crp * suspected renal insufficiency from blood tests

Keywords: probiotics intestinal microbiome radiotherapy
study of open and percutaneous release of acquired trigger thumb

Conditions: Trigger Thumb

Summary: trigger finger, also known as trigger digit or stenosing tenovaginitis, is caused by a size mismatch between the flexor tendon and the a1 pulley, which is generally characterized by pain, swelling, the limitation of finger range of motion and a symptomatic locking or clicking sensation. conservative treatment options include the application of non-steroidal anti-inflammatory drugs (nsaid), physiotherapy, electrotherapy, splinting and corticosteroid injection but not always effective with regard to frequent recurrence. open surgical release of the a1 pulley remains the gold standard of treating symptomatic trigger finger. while percutaneous release is a minimal invasive alternative and gaining popularity for the index, middle ring and little fingers, investigations for the surgical efficacy on thumb is few and far between. investigators believe that a carefully conducted operation with proper positioning of the thumb, wide-awake approach and meticulous technique can achieve similar efficacy and safety in terms of possibly less intraoperative pain, imperceptible scar and early return to daily activities and routine work. the hypothesis of this study is that by using a proper positioning of thumb, wide awake approach and meticulous technique in conducting percutaneous release of trigger thumb can achieve similar efficacy and safety compared to that of open release surgical method. moreover, percutaneous release of trigger thumb can generate less intraoperative pain, imperceptible scar and promote early return to routine work. hence, the objective of this study is to investigate and compare the safety, effectiveness and outcome of percutaneous release versus traditional open release for trigger thumbs.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of trigger thumb with green's staging graded 2-4 * patients were unresponsive to conservative treatments for more than 3 months (nonsteroidal anti-inflammatory drugs, physiotherapy, splinting, or injection of steroid) exclusion criteria: * with history in rheumatoid arthritis * unable to give verbal or written consent.

Keywords: trigger finger disorder trigger thumb minimally invasive surgical procedures orthopedics
effects of maximum strength and acceleration ability on performance and training in wheelchair sports

Conditions: Spinal Cord Injuries; Athletes; Wheelchair

Summary: the goal of this observational study is to learn about the relation between grip position and maximal strength and power in wheelchair rugby and basketball athletes. the main question is to investigate the relationship between maximal isometric force, acceleration, and sprint time. participants will * pull in their sport wheelchair against a force transducer * push in their sport wheelchair from a force transducer * accelerate as fast as possible with one push * accelerate as fast as possible over a distance of 20m researchers will compare the wheelchair basketball against wheelchair rugby players to see if there is a difference in the parameters.

the study duration is approximately 2 hours per participant. first, the screening will be done and the participant does a warmup (\~30 min). after that, the participant gets ready for testing, which will last for approximately 90 minutes. in each test, the participants have trial rounds to familiarize with the test procedure. the testing consist of three different exercises, the isometric strength test (isomst), the maximum initial push propulsion (mipp) and the sprint. in the isomst a pull setup which was already used in literature and a push setup which has yet to be validated will be used. for the pull setup, the chair of the athlete is fixated on the wall which results in a static situation and allows for an isometric effort. for the push setup, a bumper is installed on the wall, against which the athletes can push with their chair. different grip position will be measured. in the mipp test the participants are instructed to accelerate as quickly as possible from standstill with only one push on the rim. the mipp will be executed with several different grip positions, equal to the isomst. for the sprint, 20m will be marked out on a playing court. the athletes are instructed to complete the distance as quickly as possible. several split times as well as the total time will be measured.

Eligibility criteria:
inclusion criteria: * squad members or doing more than 3h per week wheelchair basket/rugby training * adequately informed and consent confirmed per signature exclusion criteria: * pregnancy based on anamnesis * acute illness, injury, infection, etc., which would impact the measurements.

Keywords: maximal strength sprint time maximal acceleration
can sars-cov-2 viral load and covid-19 disease severity be reduced by resveratrol-assisted zinc therapy

Conditions: Covid19; SARS-CoV Infection

Summary: administration of zinc and resveratrol or double placebo for a period of 5 days and will be monitored for a 14 day period in covid-19 positive patients in an outpatient setting

research question: in ambulatory, non-hospitalized patients with sars-cov-2 infection, is it possible to utilize resveratrol as a transporter for zinc treatment as means to minimize viral load and severity of resulting covid-19 disease? 60 ambulatory sars-cov-2 positive volunteers who will be randomized into one of two treatment arms to receive either zinc and resveratrol or double placebo for a period of 5 days and will be monitored for a 14 day period. it is anticipated to take approximately 20 weeks to accrue this cohort resulting in an estimated active project period of 22 weeks, although it may take up to 12 additional weeks to collect all of the data related to covid-19 admissions in the cohort.

Eligibility criteria:
inclusion criteria: 1. adults (18 - 75) with a nasal swab confirmed sars-cov-2 infection; testing positive within 4 days of enrollment 2. ability to read, understand and provide informed consent (no legally authorized representatives may consent on their behalf) and study assessments in english 3. ability for subject to comply with the requirements of the study (must/will have a valid email address, internet connection and phone number) 4. willingness to self limit medications and supplements and report what they are taking 5. comfortable self-administering oral medication and nasal swab sampling 6. willingness to permit a review of their medical history and to provide medical data from their electronic medical record for the period of enrollment (14 days) and until resolution of covid-19 related events. individuals who are not current swedish patients will be asked to identify their provider of record and provide access to specific elements of their electronic health record. 7. reside within twenty-five miles of one of the swedish campuses: first hill, ballard, edmonds, issaquah, cherry hill. exclusion criteria: 1. reported history or evidence of impaired liver or kidney function: gfr \ 2x ult or inr \> 2x ult in the absence of anticoagulants 2. known hypersensitivity to zinc or resveratrol 3. diagnosis of covid-19 or sars-cov-2 infection \>4 days before enrollment 4. preexisting severe pulmonary disease requiring supplemental oxygen 5. clinically evident impairment of cognitive function, per physician discretion 6. active substance abuse that may prevent the subject from completing the protocol requirements, per physician discretion. 7. active psychotic or affective disorder that may prevent the subject from completing the protocol requirements, per physician discretion. 8. pregnant or lactating females. 9. coumadin treatment that can not be halted during the study period

Keywords: covid19 sars-cov-2 zinc resveratrol
the diagnostic value of combinatory eus and ercp in unclear lesions

Conditions: Neoplasms; Biliary Stricture; Biliary Tract Neoplasms; Biliary Tract Diseases

Summary: ercp with brush cytology has a poor to moderate accuracy in unclear biliary lesions. endoscopic ultrasound (eus) with fine needle aspiration (fna) for cytology may override some of these shortcomings. the current prospective study, performed in a tertiary university center, aims to study the feasibility, the accuracy and the clinical value of combinatory ercp and eus in unclear biliary lesions.

the eligible study participants with unclear biliary lesions referred for an ercp to the sahlgrenska univeristy hospital endoscopy unit will be subjected to ercp with/without brush cytology followed by eus with/without fna. the results of ercp and eus will be compared to the pathology report of surgical specimens in resected patients or to clinical follow up at 12 months post-eus in non-resected patients.

Eligibility criteria:
inclusion criteria: * patients with unclear lesions or strictures in the biliary tract referred for endoscopy work up exclusion criteria: * patients unwilling to participate * patients unfit for eus and ercp

Keywords: endosonography endoscopic retrograde choledochography
indiana university gastrointestinal motility diagnosis registry

Conditions: Eosinophilic Esophagitis; Gastroesophageal Reflux Disease (GERD); Gastroparesis; Functional Vomiting; Irritable Bowel Syndrome (IBS); Constipation; Chronic Intestinal Pseudo-obstruction; Fecal Incontinence; Small Intestinal Bacterial Overgrowth

Summary: develop a registry (list of patients) with accurate clinical motility diagnosis. this registry will help the doctors to identify the patients with specific disease conditions. it will also help in promoting future research in gastroenterology motility disorders

develop a registry (list of patients) of patients seen the clinics with motility disorders. motility diagnosis based on billing diagnostic codes are not accurate. motility diagnosis will be made by physicians with specialized in gi motility, based on clinical consensus of diagnostic criteria. the information gathered from the database will be used to help promote future clinical research in the gi motility and neurogastroenterology unit at indiana university school of medicine. gastrointestinal motility symptoms are very common. it encompasses a wide range of problems, such as dysphagia, heartburn, nausea, emesis, food regurgitation, abdominal distension, weight loss, postprandial bloating, constipation, and diarrhea. an accurate diagnosis is essential in order to promote cost-effective treatment and future research to benefit patients with gi motility disorders specific aims 1. primary aim: identification of patients by accurate motility diagnosis 2. secondary aims: 1. to develop patient reported outcome (pro) measurements in patients with small intestinal bacterial overgrowth (sibo) 2. to develop patient reported outcome (pro) measurements in patients with gastroparesis

Eligibility criteria:
inclusion criteria: 1. patients who presented to the gi outpatient clinics, in-patient consult service, and outpatient endoscopy centers within the division of gastroenterology and hepatology 2. carries a diagnosis of gi motility disorder based on the diagnostic criteria listed in table exclusion criteria: 1. coexisting medical conditions that may limiting participation in clinical research trial

Keywords: eosinophilic esophagitis chronic intestinal pseudo-obstruction small bowel dysmotility sibo vomiting functional dyspepsia functional bloating gastroparesis
a primary care intervention for weight management

Conditions: Healthy

Summary: the study will test whether adding brief counseling visits with an ancillary health care provider (a nurse or nursing assistant) will induce additional weight loss, as compared with quarterly physician visits alone. all visits will take place at the site of usual patient care (i.e., the primary care clinic).


Eligibility criteria:
inclusion criteria: body mass index (bmi) of 27 to 50 kg/m2 capacity to provide informed consent ability to find transportation to and from counseling sessions willingness to be randomized to either program commitment to attend all sessions and to complete study-related assessments, including blood tests and questionnaires exclusion criteria: type i diabetes myocardial infarction or stroke within the previous 6 months clinically significant renal or hepatic disease (as judged by a study physician) history of cancer in the past 5 years congestive heart failure requiring diuretics previous weight loss surgery endocrine conditions that may cause weight gain, including unstable thyroid disease or hypercortisolism initiation of therapy with or dose change to any of the following medications within 6 weeks of starting the study: insulin; metformin; sulfonylurea; thiazolidinedione; hmg-coa reductase inhibitor ("statin"); or ssri for depression long-term use of any of the following medications: oral or high-dose inhaled steroid; atypical antipsychotic; tricyclic antidepressant; antiepileptic; any prescription or over-the-counter drug for weight loss systolic blood pressure \> 160 or diastolic blood pressure \> 100 hemoglobin a1c ≥ 10 pregnancy or lactation clinically significant psychiatric disease, including major depression, eating disorders, or substance abuse
lung resection and pulmonary rehabilitation

Conditions: Pulmonary Rehabilitation; Lung Cancer

Summary: lung cancer is the most common cancer in the world and surgical resection remains the gold standard curative treatment in early stage non-small cell lung cancer. however, surgery itself is the direct cause of pulmonary function impairment, which dramatically reduces patients tolerance to exercise and their quality of life. pulmonary rehabilitation (pr) complements surgical treatment and improves patients' exercise and functional capacity, decreases dyspnea, improves health status. our aim is to examine the effectiveness of pr applied after lung resection in patients with lung cancer, 2- to determine whether the respiratory exercise training given to patients who could not participate in the pr program is effective.

pulmonary rehabilitation (pr) is an evidence-based, interdisciplinary, comprehensive exercise program that targets patients with symptomatic chronic respiratory disease. pr integrates exercise and training interventions into a personalized treatment program. pr has become an important component of the general treatment strategy in patients with high-risk surgical diseases such as lung resection. it helps patients return to normal not only physically, but also emotionally and mentally. in patients with lung cancer, preoperative pr increases exercise capacity, decreases post-operative morbidity and mortality. although it is reported that the pr program applied in the post-operative period increases physical performance and improves the quality of life, referral of patients in need of the pr unit is less than 25%. there is a need to increase the awareness of both pulmonologists and thoracic surgeons about the benefits of the pr program, which is a non-pharmacological and effective intervention. the investigators have had two objectives in this study. 1- to examine the effectiveness of pr applied after lung resection in patients with lung cancer, 2- to determine whether the respiratory exercise training given to patients who could not participate in the pr program is effective. an 8-week comprehensive outpatient pr program will applied to half of 66 patients with non-small cell lung cancer who underwent lung resection, and the other half received respiratory exercise training. after the intervention, the results of both groups will compare.

Eligibility criteria:
inclusion criteria: * patients who had undergone surgery for non-small cell lung cancer in the last two years * patients who had no chemotherapy or radiotherapy exclusion criteria: * patients who were found unsuitable with the cardiology consultation * patients with psychiatric problems * patients with severe joint diseases * reluctant patients

Keywords: pulmonary rehabilitation lung surgery lung cancer
evaluation of low flow and normal flow anesthesia management in robotic assisted laparoscopic surgeries

Conditions: Oncology

Summary: robotic-assisted laparoscopic surgery has many advantages compared to conventional open surgery, such as less postoperative pain, shorter hospital stays, and faster recovery times. robot-assisted surgeries require general anesthesia. in our clinic, we routinely apply low-flow anesthesia methods in addition to normal flow methods in many surgical applications, according to clinician preferences. the aim of this study is to determine the effects of low flow (0.5 lt/min) and normal flow (\>1 lt/min) anesthesia applications in robotic-assisted laparoscopic surgeries. to compare perioperative hemodynamic and respiratory parameters in terms of inhalation agent and soda lime consumption.

robotic surgery is the performance of laparoscopic surgery using a robotic interface. the robotic surgery system used today is called da vinci s. in surgeries performed with the help of a robot, the surgeon can work more precisely and with greater maneuverability. therefore, an operation can be performed that is less traumatic for the patient than other methods.robotic-assisted laparoscopic surgery has many advantages compared to conventional open surgery, such as less postoperative pain, shorter hospital stays, and faster recovery times. robot-assisted surgeries require general anesthesia. in these applications, fresh gas flow in anesthesia systems can be made with traditional high, normal or low flow strategies, depending on the preference of the clinicians.low-flow anesthesia creates a breathing air closer to physiological conditions during anesthesia by heating and humidifying the inhaled gases. in addition, it provides cost advantage by reducing inhalation agent consumption and reduces atmospheric pollution. it is suggested that the use of both fresh gas flow amounts does not pose a safety risk for patients, and that the use of low-flow anesthesia methods should be more widespread due to the advantages it provides. in our clinic, investigators routinely apply low-flow anesthesia methods in addition to normal flow methods in many surgical applications, according to clinician preferences. the aim of this study is to determine the effects of low flow (0.5 lt/min) and normal flow (\>1 lt/min) anesthesia applications in robotic-assisted laparoscopic surgeries. to compare perioperative hemodynamic and respiratory parameters in terms of inhalation agent and soda lime consumption.

Eligibility criteria:
inclusion criteria: * ages 18-75 * asa i,ii * patients undergoing robotic-assisted laparoscopic surgery exclusion criteria: * asa iii,iv,v * those with serious cardiac, respiratory, hepatic, renal disease * people with mental status disorders, psychiatric illnesses * patients with hearing problems and glaucoma * desire to be out of work

Keywords: low-flow anesthesia robotic-assisted surgery general anesthesia
electrophysiological investigation and rtms intervention of ambulatory central processing of freezing of gait in parkinson's disease

Conditions: Parkinson's Disease; Parkinson's Disease With Freezing of Gait

Summary: the gait symptoms are usually refractory to the dopaminergic agents and some other resolutions, i.e. repetitive transcranial magnetic stimulation (rtms) should be searched for in this regard. to study the impact of rtms, investigators will adopt a domestically developed ambulatory recorder (pk-16ch exg) for the concomitant recording of the electroencephalographic and electromyographic signals for pd patients when walking in the gait laboratory or when conducting leg dorsiflexion movement on sitting.

the bereitschaftspotential (bp), event related synchronization (ers) and event related dysynchronization (erd) will be analyzed for the investigation of the possible differences of brain activities prior to leg voluntary movement between patients and controls. in addition, the synchronized recorded gait parameters for gait ignition,turning and termination will also be analyzed. the information gathered will allow us to further understand the pathophysiology of the gait freezing in pd. investigators will deliver a course of rtms with intermittent theta burst paradigm of the leg motor cortex to investigate whether the non-invasive brain stimulation can ameliorate the gait freezing in pd patients. the subjects will be assessed before and 4 times after rtms during an 8-week period with clinical scoring batteries and electrophysiological recording as aforementioned. at the end of the 8th week, the test group and sham group will cross over and undergo the same procedures as aforementioned. the serial comprehensive investigations in this project will not only promote our understanding of the gait freezing pathophysiology but also may charge a novel trail for the management of long suffering symptom of the pd patients.

Eligibility criteria:
inclusion criteria: patients with pd will be diagnosed according to the brain bank criteria. exclusion criteria: 1. patients had past history of epilepsy, intracranial operation or brain tumor. 2. hoehn \& yahr stage v.

Keywords: parkinson's disease freezing of gait movement-related cortical potential repetitive transcranial magnetic stimulation
bonaph1de, a prospective observational study of patients with primary hyperoxaluria type 1 (ph1)

Conditions: Primary Hyperoxaluria Type 1

Summary: the purpose of this study is to describe the natural history and progression of patients diagnosed with ph1, and to characterize the long-term real-world safety and effectiveness of lumasiran.


Eligibility criteria:
inclusion criteria: * documented diagnosis of ph1, per physician's determination exclusion criteria: * currently enrolled in a clinical trial for any investigational agent

Keywords: ph1 lumasiran primary hyperoxaluria type 1