Kornimate/medical-research-clean huggingface dataset:
small-vessel disease burden and early risk of stroke after transient ischemic attack

Conditions: Diagnosis of TIA; MRI

Summary: predicting the risk of stroke remains a challenge in the management of transient ischemic attack (tia). in addition to clinical variables, morphological features such as the presence of a diffusion weighted sequence (dwi) lesion and carotid stenosis of at least 50% improve risk stratification and are considered in the literature. score abcd3-i1. several studies have shown that brain microhemorrhages are associated with the risk of early stroke in patients with tia. data on white matter hypersignals on the t2-weighted sequence or flair (fluid attenuated inversion recovery) are more conflicting. the global microangiopathic load, including the gaps, the hypersignals of the white matter, the perivascular spaces visible on mri in the basal ganglia, especially when they are very numerous (\> 20) and the gaps, have recently been described as being associated with stroke risk within 2 to 3 years of tia or ischemic stroke. to date, the predictive value of global microangiopathic burden on early stroke risk in the course of tia is not known.


Eligibility criteria:
inclusion criteria: * patients with probable tia with regression of symptoms within 24 hours (unilateral motor or sensory disorders affecting the face and / or limbs , language disorder, blindness of an eye or amputation of a visual field) * patients with possible ait with 2 of these symptoms associated: fear of heights, diplopia, dysarthria, disorders of swallowing, loss of balance, isolated sensory symptoms affecting only part of a limb or hemiface. * patient who have had a brain mri. * patient over 18 year-old. * patient who give their non opposition to participate at the study. exclusion criteria: -
quaternium-15, use test

Conditions: Allergic Contact Dermatitis Towards Quaternium-15

Summary: the study is required by the fda as part of a post-marketing commitment. the purpose of the study is to compare the reactivity of the true test quaternium-15 patch and a real use exposure.the subjects will wear the patch test for 48 hours and reading will be performed day 3 or 4. the use test will be applied from day 3 or 4 and untill reaction appears. reactions from respectively true test and use test will be compared using the mcnemar change test.


Eligibility criteria:
inclusion criteria: * sensitivity to quaternium-15 * age more than 18 years exclusion criteria: * topical or systemic treatment with corticosteroids or immunosuppresives. * treatment with uv-light * widespread active dermatitis or dermatitis on test area
first responder aphasia strategy training

Conditions: Aphasia

Summary: this study aims to determine the impact of a collaborative approach to training law enforcement officers and first responders about aphasia including their knowledge and confidence in communicating with individuals with aphasia that they may encounter in the field. 75 participants from madison police department will be enrolled and can expect to be on study for up to 6 months.

the investigators will partner with the madison police department to provide training and programming to law enforcement officers and first responders. training will include direct teaching, aphasia simulations, scenario-based training and a panel with persons with aphasia with the goal of increasing confidence for law enforcement officers and first responders providing services to and communicating with persons with aphasia. participants will take 3 surveys over 6 months.

Eligibility criteria:
inclusion criteria: * employed by madison police department as a first responder or law enforcement officer * willing and able to provide informed consent * willing to comply with all study procedures and be available for the duration of the study exclusion criteria: * not employed as a first responder or law enforcement officer with madison police department
feasibility of visual field testing with a virtual reality headset

Conditions: Glaucoma

Summary: this study aim to determine the feasibility of using a virtual reality (vr) headset (htc vive) to test the visual field. the vr headset test will be compared to a conventional visual field test, using the humphrey field analyzer. the investigators will include 10 healthy patients without visual field defect, 10 patients with early glaucomatous visual field defect, and 10 patients with advanced visual field defect. each patient will perform the conventional test twice and the vr headset test 4 times, divided in 3 visits within a 2 month period. the results of the tests (sensitivity thresholds) will be compared. the investigators hypothesize that the results of the conventional and vr tests will be similar.


Eligibility criteria:
inclusion criteria: * previous visual field test with humphrey field analyzer indicating normal field, early glaucomatous field damage, or advanced glaucomatous field damage, according to canadian glaucoma society guidelines. * ability to understand and consent to the study. exclusion criteria: * presence of non-glaucomatous pathology that could influence the visual field test, such as media opacities. * previous intraocular surgery less than 6 months from inclusion. * difficulty to execute a reliable visual field test. * potential contra-indications to use of virtual reality headset, including: anxiety disorder, pregnancy, seizure disorder, cardiac pacemaker or other implantable device, severe vertigo or balance disturbance.
effects of feeding schedule on the development of icu delirium

Conditions: ICU Delirium

Summary: this study will investigate if enteric feeding schedules alter the development of delirium in intensive care unit patients who have been placed on mechanical ventilation. delirium is an altered state of consciousness, which can involve agitation, inattention, and decreased awareness. we will enroll intensive care unit patients who have been placed on a ventilator and are being given tube feedings. we will randomize participants into two groups: one group will receive continuous feedings via feeding tube, and the other group will receive feedings on a schedule to mimic breakfast, lunch, a snack, and dinner. subjects will be assessed for the development of delirium. subjects will also be monitored for sleep quality.

patients will need to have at least 48 hours of enteric feedings to be included, and will be stratified by their apache iv score. patients will be randomized into time restricted feeding vs continuous feeding by investigators, with no change in caloric intake nor nutrient content from orders. patients will be assessed for delirium using the cam-icu (confusion assessment method in the intensive care unit) screening tool every twelve hours. at the time of the cam icu assessment, as part of the experimental design, the patient's sleep will be monitored by x8 sleep profiler device, placed and secured to their forehead, and the sleep profiler device will collect information regarding sleep quality as assessed by relative delta power, relative theta power and relative beta power.

Eligibility criteria:
inclusion criteria: * admitted to the icu * mechanically ventilated * receiving enteric feedings for at least 48 hours exclusion criteria: * pregnancy * previously diagnosed neurocognitive disorders, * alcohol withdrawal and history of alcohol dependence

Keywords: mechanical ventilation tube feeds
safety, immunogenicity of rts,s/as02a, and rts,s/as01b malaria vaccines in malaria-experienced adults.

Conditions: Plasmodium Falciparum

Summary: the candidate malaria vaccine rts,s/as02a developed by gsk biologicals demonstrated 30% efficacy against clinical episodes of malaria and approximately 58% efficacy against severe malaria disease. as a potential improvement to rts,s/as02a, another candidate vaccine rts,s/as01b is being developed in parallel in collaboration with the walter reed army institute of research (wrair). this study will be the first administration of the rts,s/as01b vaccine to the african adults to establish safety and immunogenicity in this population. preliminary indication of vaccine efficacy with this adjuvant will be established by monitoring the time to the first infection with plasmodium falciparum.

the study comprises of 3 groups and the participating subjects will be randomly allocated to one of the three groups. the first group will receive rts,s/as01b, the second group will receive rts,s/as02a and the third group will receive rabies vaccine. immunization will be given by im injection on 0, 1, 2 month schedule. infants will be followed up daily for 7 days for solicited symptoms and 30 days for unsolicited symptoms after each vaccine dose. serious adverse events will be recorded throughout the study period. a week prior to dose 3, subjects will be treated with a licenced anti-malarial drug. starting from two weeks after dose 3, the subjects will be monitored for a 14-week duration for detection of malaria infection.

Eligibility criteria:
inclusion criteria: * healthy male or female volunteers aged between 18 and 35 years at the time of first vaccination who have given written consent for their participation in the study were included * if the volunteer is female, she must be of non-childbearing potential, i.e. either surgically sterilized or one year post-menopausal; or, if of childbearing potential, she must be abstinent or have used adequate contraceptive precautions for 30 days prior to vaccination, have a negative pregnancy test and must agree to continue such precautions for two months after completion of the vaccination series exclusion criteria: * if a subject plans to take vaccine not foreseen by the study protocol within 30 days of the first dose of vaccine(s) with the exception of tetanus toxoid will be excluded * volunteers with any confirmed or suspected immunosuppressive or immunodeficient conditions * family history of congenital or hereditary immunodeficiency * history of allergic reactions to previous immunizations * hbsag positive subjects * history of splenectomy * pregnant or lactating females will be excluded from the study
intraoral cryotherapy in root canal retreatment

Conditions: Cryotherapy Effect

Summary: the aim of this study was to evaluate the effect of intraoral cryotherapy application on postoperative pain in single and multiple visit retreatment of teeth with symptomatic or asymptomatic apical periodontitis. this clinical trial was also investigate the potential of intraoral cryotherapy application to reduce on postoperative analgesic use of patients in line with the results obtained. a total of 118 patients who met the inclusion criteria were selected for the study. the patients were randomly divided into two groups as single visit and multiple visit (n=59). then, each group was randomly divided into three subgroups as control (without cryotherapy), 15 minutes of cryotherapy, and 30 minutes of cryotherapy. twenty two teeth were retreated in each cryotherapy group and 15 teeth in each control group. visual analogue scale (vas) was used to evaluate and compare postoperative pain. postoperative analgesic use of patients was also recorded.


Eligibility criteria:
inclusion criteria: * 18 and 65 year-old patients. * patients with pre-treated teeth diagnosed with symptomatic or asymptomatic apical periodontitis. * patients who can tolerate the treatment physically and mentally. exclusion criteria: * the presence of any systemic disease, * the presence of any allergic reactions or pregnancy, * use of any analgesic or antibiotic medication within 7 days, * use of corticosteroid within 6 months, * severe periodontal disease (periodontal pockets \>3 mm) in the pretreated tooth, * surgical endodontic treatment, * having drainage, * periapical index (pai) score 1 and 2, * excessively curved, excessively long or short roots, calcified or resorbed root canals, * immature apices, * complications like perforation, overfilling, broken files

Keywords: analgesic cryotherapy periapical periodontitis postoperative pain retreatment
dextran-based priming vs. crystalloid and mannitol-based priming solution in adult cardiac surgery

Conditions: Heart Disease

Summary: this study will compare two priming solutions for extracorporeal circulation, one based on dextran 40, one based on crystalloid and mannitol. primary endpoint is oncotic pressure during cardiopulmonary bypass. secondary endpoints included fluid balance and organ functions.

this is a prospective, single center, double-blinded, randomized controlled clinical trial. eighty patients are randomized 1:1 to either cardiopulmonary bypass with the dextran-based solution or standard priming with ringer-acetate and mannitol. primary endpoint will be oncotic pressure during cardio pulmonary bypass. secondary endpoints include perioperative fluid balance, coagulation, platelet function, postoperative bleeding volume, transfusion requirements, renal function, liver function, pulmonary function, inflammatory activation and markers for brain and heart injury. blood samples for oncotic pressure measurements will be collected from an arterial line before and during surgery. organ function will be assessed before surgery and 2 hours cardio pulmonary bypass.

Eligibility criteria:
inclusion criteria: * age 50 - 75 years * elective cardiac surgery procedure with expected cbp time above 90 minutes * subject provides a legally effective informed consent. exclusion criteria: * known previous cardiac surgery * coagulation disorder * malignancy * kidney failure * liver failure * ongoing septicaemia * ongoing antithrombotic treatment other than acetylsalicylic acid * systemic inflammatory disorders treated with corticosteroids * not able to understand swedish

Keywords: extracorporeal circulation
tactics (targeting adherence to cholesterol-lowering therapy to improve control study)

Conditions: Hypercholesterolemia

Summary: background: this is a randomized controlled trial (rct) of two novel behavioral interventions to enhance treatment adherence and improve low-density lipoprotein cholesterol (ldl) in diabetes. among adults with diabetes, high ldl greatly increases their risk for cardiovascular disease (cvd). despite the proven efficacy of ldl control(\<100 mg/dl) in preventing cvd, the control rate is low. poor adherence to treatment(diet, exercise and medication) is the main reason for this poor control. aims: this study will test two telephone-delivered interventions, a transtheoretical stage-matched intervention (smi) and a prospect theory-based framing effects intervention (fei). the investigators hypothesize that both smi and fei will be more effective in improving ldl control than an attention placebo intervention (api) at 6 months. smi and fei will also be more effective in increasing adherence to medications, diet and exercise than api at 6 months. methods: the investigators will recruit 246 adults with diabetes and high ldl despite being on medications. key outcomes are adherence to diet, exercise and medication, and ldl control. the interventions will be standardized and fidelity of intervention maintained. using a blinded rct the investigators will test the effect of smi and fei compared to api on ldl control and adherence. all analyses will be intent to treat. significance: this project will provide important information to improve diabetes-related behavior and lead to the implementation of novel interventions for lowering ldl in primary care settings among adults with diabetes. it may also provide the scientific rationale to use such approaches to control other risk factors in diabetes.


Eligibility criteria:
inclusion criteria: * adults with diabetes * ldl greater than or equal to 100 * cholesterol-lowering drug therapy for \> 6 months * a working telephone * at least 2 primary care visits in the past 1.5 years exclusion criteria: * poor short-term survival (\< 1 year) * inability to understand english * recent major surgery (\< 3 months) * patients temporarily in the area * inability to provide consent

Keywords: cholesterol diabetes adherence
efficacy of multi-waved locked system laser versus cold compression therapy on breast cancer-related lymphoedema

Conditions: Lymphedema

Summary: this study was conducted: * to investigate the effect of mls laser in the management of patients with unilateral bcrl regarding lymphatic flow, volumetric measurement and hrql assessment. * to investigate the effect of cct in the management of patients with unilateral bcrl regarding lymphatic flow, volumetric measurement and hrql assessment. * to compare the effect of mls laser versus cct in the management of patients with unilateral bcrl regarding lymphatic flow, volumetric measurement and hrql assessment.


Eligibility criteria:
inclusion criteria: * female patients with unilateral bcrl. * age of patients above 18 years old * patient history of modified radical mastectomy, chemotherapy and/or radiotherapy. * patients undertaken have history or current hormonal treatment. * patients with moderate lymphoedema (20-40% increase in extremity volume) exclusion criteria: * patients who have severe co-morbid diseases. * presence of other cancers, cancer recurrence, lymphatic malformation, or vascular disease * patients who are having current chemotherapy and/or radiotherapy. * patients who have bilateral lymphedema, current metastases, elephantiasis, infection, lymphangiosis carcinomatosa, cellulitis, venous thrombosis, or congestive heart failure * patients with musculoskeletal disorders affecting upper extremity.
efficacy of chronic disease self-management program in people with schizophrenia

Conditions: Schizophrenia

Summary: this was a randomized controlled behavioral intervention trial to assess the efficacy of investigating program of chronic disease self-management program in people on schizophrenia patients conditions of depression, activities of daily living, social function, work, and quality of life.

subjects were randomized to intervention group and control group. the primary outcome included eight measures, stanford self-management questionnaire, the beck depression inventory-ii, the activities of daily living rating scale iii, the instrumental activities of daily living scale, the participation measure-3 domains, 4 dimensions, the work behavior inventory, and the schizophrenia-quality of life questionnaire.

Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia by dsm-5 * age \> 20 years * stable mental symptoms * willing to sign the subject's consent exclusion criteria: * history of severe brain injury * substance abuse * diagnosis of intellectual developmental disorder * unable to follow instructions

Keywords: chronic disease self-management program
sensory adapted dental environments to enhance oral care for children with and without dental fear and anxiety

Conditions: Dental Fear and Anxiety

Summary: this study is a randomized clinical trial investigating the effectiveness of a sensory adapted dental environment (sade) alone and together with a video-based modeling (vbm) component (vbm-sade), compared to a regular dental environment (rde) and/or vbm alone, to reduce anxiety, distress behavior, pain, and sensory discomfort during a dental cleaning in children with and without dental fear and anxiety.


Eligibility criteria:
inclusion criteria: * male or female, aged 6 through 12 years, of any race/ethnicity; * english- or spanish-speaking child and parent; * have experienced at least one prior dental cleaning; * if recruited from the emergency department, emergency severity index (esi) must be level v or iv (to ensure that greater severity ped patients not be recruited). exclusion criteria: * dental cleaning within the previous 4 months (i.e., not in need of cleaning); * plan to move out of the area within 6 months; * intellectual or developmental disability (e.g. autism; highly co-morbid with sensory processing difficulties); * disability that would interfere with oral care (e.g. cleft lip/palate, cerebral palsy, genetic/endocrine/metabolic dysfunction) or medical condition that would place the child at increased risk during the study (e.g., uncontrollable seizures); * daily use of anti-cholinergic drugs (i.e., interferes with eda recordings); * presence of orthodontia (braces) or with a plan to get braces in the upcoming 6 months

Keywords: sensory adapted dental environment video-based modeling dental care dental anxiety dental fear
validation of a parental questionnaire for screening children for neurovisual disorders

Conditions: Children Suffering From Cortical Visual Impairment

Summary: some children present visual difficulties linked not to damage to the eye, but to damage to the brain. this type of dysfunction of the visual cerebral pathways leads, for example, to difficulties in recognition, visuomotor coordination or visuo-spatial disorders. these highly specific disorders are known as "cortical visual impairment" (cvi). despite their real impact on children's development, these disorders are still poorly diagnosed in the french-speaking world. as a result, follow-up and care for these children are poorly adapted. a better understanding of neurovisual disorders and the availability of validated tools in french are therefore essential. indeed, it is currently considered that 3 to 4% of children aged four to six, i.e. around one child per kindergarten class, have a cvi following a neuro-logical lesion acquired in the perinatal period. because of the lack of a valid tool in french, the aim of the present study is to provide the results of a validation study of a parental questionnaire for screening children with warning signs of cvi in french. this questionnaire will be offered online using the qualtrics tool. in order to evaluate the relevance of this questionnaire, it will be proposed, on the one hand, to parents whose child (aged 3 to 12) does not present any particular developmental difficulties, and on the other hand, to parents whose child (aged 3 to 12) seems to present signs of neurovisual disorders. by comparing their answers, the investigators hope that certain questions will reveal elements typical of neurovisual disorders/cvi, thus demonstrating the relevance of this questionnaire in facilitating diagnosis.


Eligibility criteria:
inclusion criteria: * parents of a child aged between 3 and 12 * their mother tongue must be french, to ensure that they understand the questions asked in writing. control group: - children of the parents surveyed who do not present any medical, school or family developmental particularities. clinical group - children of the parents interviewed who present warning signs of cvi reported by a multidisciplinary team specialized in visual impairment. exclusion criteria: * no specific criteria (see inclusion criteria)
evaluation of the clinical efficacy and safety of dapoxetine, combined dapoxetine with folic acid and combined dapoxetine with vitamin b12 in treatment of patients with premature ejaculation

Conditions: Premature Ejaculation

Summary: this study will aim to assess of the clinical efficacy and safety of dapoxetine, combined dapoxetine with folic acid and combined dapoxetine with vitamin b12 in treatment of patients with premature ejaculation: a randomized placebo-controlled clinical trial.

in a single-blind placebo-controlled clinical study, it will be carried out on 120 patients with pe. all patients will be randomized equally divided into four groups (30 patients each). group 1 was given placebo in form oral multivitamin tablet 1 h before intercourse. group 2 was given on-demand 30 mg dapoxetine 1-2 h before intercourse. group 3 was given on-demand 30 mg dapoxetine 1-2 h before intercourse and daily oral supplementation of 0.5 mg folic acid. group 4 was given on-demand 30 mg dapoxetine 1-2 h before intercourse and daily oral supplementation of 0.5 mg vitamin b12

Eligibility criteria:
inclusion criteria: premature ejaculation exclusion criteria: * erectile dysfunction * diabetes mellitus * chronic prostatitis * advanced renal or hepatic diseases * neurological diseases

Keywords: premature ejaculation