Kornimate/medical-research-clean huggingface dataset:
preoperative rapid pou ultrasound assessment in critically ill patients undergoing emergency surgery

Conditions: Emergency Surgery

Summary: with the development of society, the number of emergency critical operations is increasing year by year. traditionally, the patient's systemic and circulatory status is indirectly assessed by testing and blood pressure heart rate. there are cases where the diagnosis is imperfect and the results are unreliable. preoperative pou rapid ultrasound is a preoperative bedside ultrasound evaluation method first proposed by the anesthesiology department of huaxi hospital (three engineering units). this project will cooperate with huaxi hospital to explore whether the effect of intraoperative anesthesia management under pou guidance is better than traditional anesthesia management. this study will provide a new preoperative evaluation anesthesia management program for emergency critically ill patients with important clinical and social significance.

according to the inclusion and exclusion criteria, the patients will be randomly divided into two groups：in the control group, the anesthesiologist performed according to the existing preoperative evaluation program and existing experience, and guided the anesthesia management with the evaluation results.the experimental group used pou protocol ultrasound to perform a heart scan and a standard scan, a large vascular scan under the xiphoid, a body cavity scan, a standard section, and a lung scan in 10 minutes. comprehensive preoperative circulation and assessment of systemic conditions, and guided intraoperative anesthesia management with assessment results.

Eligibility criteria:
inclusion criteria: * 1.pulse oxygen saturation (spo2) ≤ 92% when inhaling air. * 2.respiratory frequency ≥ 20 beats / min. * 3.systolic blood pressure (sbp) \<90mmhg. * 4.heart rate (hr)\>100 times/min. * 5.requires positive inotropic drugs and/or vasopressors. * 6.need artificial ventilation. * 7.signing informed consent. exclusion criteria: * 1.age \<14 years old. * 2.unable to perform ultrasound evaluation (bandage, clam shell). * 3.participated in other clinical trials in the first 3 months of the study. * 4.researchers believe that it is not appropriate to include this tester. * 5.any reason can not cooperate with this study. * 6.cardiac surgery patient * 7.organ transplant patient. * 8.obstetric surgery patient. * 9.you can start rescue after entering the room (such as cpr, etc.), and you are not allowed to perform ultrasound scans.

Keywords: anesthesia preoperative rapid pou ultrasound clinical trials
accuracy of measurement of surface body temperature using the health e pod device (card guard) compared to gold standard equipment

Conditions: All Children Admitted to the ED; Children With Fever

Summary: objective to evaluate the accuracy of data acquisition by health e pod device in measurement of body temperature, to compare it to a standard body temperature measure equipment about 400 consecutive patients admitted to peu in assaf harofeh medical center will compile the study population. basic vital signs will be recorded on admission and during hospitalization as per the peu policy and not in particular for this study. as a part of routine check-up all admitted patients undergo body temperature measure (oral or rectal - as per the peu policy and with peu devices). following an explanation and patient agreement, eligible patients (and their legal guardian) will sign informed consent and enter the study. the health e pod device will be applied to measure body temperature, immediately after the standard temperature measure has been performed by the peu professional.


Eligibility criteria:
inclusion criteria: * signed an informed consent by the patients' legal custodian / guardian (and assent by the patient when applicable). * age 0 to 18 years * clinically stable patients hospitalized in peu. exclusion criteria: * implanted pacemaker or defibrillator. * patients participating in other clinical trail.

Keywords: fever children
autoimmunity and coronary artery disease - ancillary to cardia

Conditions: Cardiovascular Diseases; Coronary Disease; Heart Diseases

Summary: to test the primary hypothesis that individuals with pre-clinical connective tissue disease related autoimmunity are more likely to demonstrate subsequent development of sub-clinical coronary artery disease.

background: connective tissue diseases have been identified as risk factors for coronary artery disease (cad). patients with connective tissue diseases such as rheumatoid arthritis and systemic lupus erythematosus have a high prevalence of cad and are younger than expected at the onset of cad. it has been proposed that the association between these connective tissue diseases and cad is related to inflammation. furthermore, circulating autoantibodies have been identified in cad and it has been hypothesized that cad may have autoimmune features. circulating autoantibodies exist prior to connective tissue disease development and the presence of such autoantibodies in asymptomatic individuals is a predictor of future clinical connective tissue disease. although the association between connective tissue disease and cad has been established, an association between pre-clinical circulating autoantibodies and early cad has not yet been explored. design narrative: to test this hypothesis, the following specific aims are proposed using the cardia database: 1) determine the association between autoimmunity measured in stored sera collected in 1992 and the subsequent development of sub-clinical cad measured in 2000 and 2005. 2) assess whether autoimmunity measured in 1992 predicts future increased levels of c-reactive protein (crp) and whether the relationship between autoimmunity and cad is mediated by crp level. these aims will be accomplished by a team of investigators within the division of rheumatology and department of preventive medicine at northwestern university. the cardia database is a product of the coronary artery risk development in young adults (cardia) study, a prospective cohort of 5108 subjects followed since 1985 for development of novel cardiac risk factors. with its extensive epidemiologic database and stored serum collected serially and available from 3500 individuals over the past 20 years, the cardia study is an ideal resource for this study.

Eligibility criteria:
no eligibility criteria

Keywords: cardiovascular diseases coronary disease heart diseases
multicentric and retrospective analysis of adolescent young adult (aya) hodgkins' lymphoma patients

Conditions: Hodgkin Lymphoma; Adolescent Behavior; Chemotherapy Effect

Summary: the principal aim of this study is to collect retrospectively all adolescent young adult patients affected by hodgkin's lymphoma and treated in pediatric or adult haemato-oncology centers. the data set collection aims to define the therapy performed and the results obtained in terms of overall survival and acute or late complications.

hodgkin lymphoma (hl) represents approximately 0.5% of cancer diagnosis each year in developed countries (1, 2). this translates to an annual incidence of 8500 individuals per year in the united states and an incidence rate of 2.49 per 100.000 lymphoid malignancies in europe (2, 3). a classical bimodal distribution is reported with a first peak occurring in patients between the ages of 15 and 30 years and a second peak in those older than 55 years (4). hl is one of the most common malignancies to occur in the adolescent and young adult (aya) population. this population is defined by the national cancer institute as people diagnosed with cancer between the ages of 15 and 39 years. the choice of therapy for aya patients is typically determined by the treatment setting and referral patterns. patients who are younger than 18 years are usually referred to pediatric centers, where many patients are treated in the context of clinical trials. for patients treated by adult haematologists many are treated in the community setting. considerable variability exists between the treatment of adult and pediatric patients, including the choice of chemotherapeutic agents and the role of radiation. in both the pediatric and adult settings there has been increasing focus on balancing the risk of relapse with the risk of secondary side effects. de-intensification for low-risk patients using pet-adapted strategies is a modern approach that has been applied to all patients with hl independent of age. variability among age groups still results in uncertainty regarding the optimal treatment approach in the aya population. this is a retrospective observational study involving italian centers that treat adolescents and young adults hodgkin lymphoma patients. this type of patients can be treated either in a pediatric institution or in adult institution with different supportive and therapeutical approaches. the primary objectives will be overall survival according to different treatment. secondary end points will be acute or late complications comparing different treatments choice in an homogeneous group of patients, progression free survival according to different treatment.

Eligibility criteria:
inclusion criteria: * all consecutive patients with diagnosis of hodgkin lymphoma with an age at diagnosis ranging between 15 and 24 years enrolled in prospective studies either in aieop group and in fil group or patients treated consecutively in single centers affiliated to aieop or fil and registered in single institutional data base. * all hodgkin subtype exclusion criteria: * none
what happens in vegas: pep to prep opportunities

Conditions: Exposure to Human Immunodeficiency Virus (Event)

Summary: observational study looking at barriers to care for individuals seeking care, post exposure prophylaxis (pep) after an actual or perceived exposure to hiv. following pep treatment subjects will be asked about there intent to transition to pre-exposure prophylaxis (prep) and surveyed about barriers to care or perceptions of care

the primary objective of this study is to assess the rate of engagement in a pep to prep hiv provider network for those patients presenting following a non-occupational hiv exposure. the development of a referral network and intensive clinical follow up of pep patients will result in more patients appropriately initiating pep, being referred to appropriate follow up, and post exposure transition and maintaining on prep (if indicated) at completion of the pep medications.

Eligibility criteria:
inclusion criteria: * actual or perceived non-occupational exposure to hiv, by self report, within 72 hours of enrollment and referred for care * able and willing to provide informed consent * available for 12 months of post expoure follow-up southern nevada ryan white defined service area exclusion criteria: * hiv+ at time of screeing via 4th genderation (antibody/antigen) testing * current pep and/or prep product condrainidications as listed in the medication product insert.

Keywords: pep npep post exposure prophylaxis non occupational exposure to hiv
evaluation of an hiv outreach program

Conditions: HIV Infections

Summary: this study evaluates outreach to hiv-infected people living in unstable housing in new york city who are new to citiwide harm reduction. one hundred and fifty people are interviewed every 6 months, and their medical records are reviewed every 6 months for a total of 18 months. the study examines how outreach, case management, housing, drug use, mental health, and quality of life are related to people's ability to get into and stay in medical care.

the study is a prospective cohort study in which 150 newly enrolled hiv-infected participants of citiwide harm reduction are followed for 18 months to assess hiv-related health outcomes. data elements include (1) face-to-face interviews focusing on housing, hiv disease severity, utilization of health care services, utilization of non-medical services, substance use, mental health, and quality of life; (2) medical chart information focusing on cd4 count, viral load, and hiv primary care visits; and (3) outreach services. the study hypothesis is that involvement with citiwide harm reduction will improve hiv-related health care utilization and outcomes.

Eligibility criteria:
inclusion criteria: * hiv-infected, living in one of 15 single room occupancy hotels served by citiwide harm reduction, new to citiwide harm reduction, at least 18 years of age, english or spanish speaking exclusion criteria: * hiv-negative

Keywords: hiv health services accessibility health services research homeless social support aids substance abuse mental health quality of life outreach harm reduction
body weight support in spinal cord injury

Conditions: Spinal Cord Injury

Summary: the purpose of this study was to evaluate the effectiveness of body weight-supported treadmill (bwst) training on static balance impairment in adults with incomplete spinal cord injury (sci) in chronic stage

the individuals who participated in this study were subjects with sci with more than twelve months of evolution. all were classified as incomplete injury class c or d according to the american spinal injury association (asia). each received training on a bwst for six weeks. two measures of stance balance were performed during the training protocol. the first measure was made before entering the training protocol; the final measure was implemented once the gait training on bwst protocol was completed. for instrumented stance balance testing, small wireless inertial motion sensors (opal sensors, apdm inc., portland, or) were placed on the subjects' waist. subjects performed instrumented stance with their eyes opened (isway). outcome measures were recorded and automatically generated using mobility lab software (apdm inc., portland, or). measures included the root mean square of sway and jerk (normalized to the range of acceleration amplitude).

Eligibility criteria:
inclusion criteria: * sci with more than twelve months of evolution. * asia c and d exclusion criteria: * patients with tracheostomy * patients with severe respiratory, cognitive and cardiovascular comorbidities * patients with peripheral nerve injury in lower limbs * patients with traumatic head injury
the relationship between positive end expiratory pressure and cardiac index in patients with acute respiratory distress syndrome (ards) managed on a fluid protocol

Conditions: Acute Respiratory Distress Syndrome (ARDS)

Summary: the objective of this study is to evaluate the association between positive end-expiratory pressure (peep) setting and cardiac function, as measured by cardiac index, in patients with acute respiratory distress syndrome (ards) who were managed on the nhlbi ards network fluid and catheter treatment trial (factt) fluid protocols.

this is a secondary cross-sectional analysis of the factt multi-center randomized controlled trial enrolling adult patients within 48 hours of ards onset from twenty medical centers across the us, some of which included more than one hospital. we studied the patients who were randomized to the pulmonary artery catheter arm of the factt study. the investigators included patients that had peep and cardiac index measurements performed within a short period of each other during the first 3 days of the factt study enrollment. since factt had a 2x2 factorial design, half of the patients were in a 'liberal fluids' study arm, and the other half were in a 'conservative fluids' study arm.

Eligibility criteria:
inclusion criteria: acute lung injury diagnosis (as defined by the american - european consensus conference on ards) of \< 48 hours in duration. patients in the pulmonary artery catheter (pac) arm of the factt study. pao2 / fio2 ratio of \< 200. data from the first 3 days of mechanical ventilation. exclusion criteria: select chronic conditions that could independently influence survival (e.g., expected 6-month survival \< 50%) and / or ventilator weaning. peep values missing. fio2 values missing. pao2 values missing. cardiac index values missing pressors and / or inotropes requirement.

Keywords: mechanical ventilation ards acute lung injury cardiac function cardiac index heart-lung interaction
the effect of motor learning on balance, mobility and performance of activities of daily living among post-stroke patients

Conditions: Stroke

Summary: the primary objective of this study is to assess - through a randomized controlled trial - the effectiveness and long-term improvement of motor relearning program on balance, mobility and performance of activities of daily living among post-stroke patients. in this two-armed randomized controlled clinical trial, a total of 66 sub-acute stroke patients who meet the trial criteria will be recruited. the patients will randomly receive task-specific training based on a motor relearning program (mrp) or a conventional physical therapy program (cpt). twenty-four rehabilitation sessions will be conducted for eight weeks. both interventions will be followed by analysis of patients' balance, gait and performance of activates of daily living at two time period; post-intervention and follow-up after 3-months, using clinical outcome measures and instrumental analysis of balance and gait.


Eligibility criteria:
inclusion criteria: * first-ever subacute (1-6 months) stroke patients; * able to give informed consent; * patients with hemiparesis: muscle power of 2-4 on medical research council-mrc muscle scale in the affected upper and lower limbs; * able to stand independently for at least one minute; * can ambulate 25 feet/10 meter (with or without assistive device). exclusion criteria: * post-stroke patients with major cognitive deficits (montreal cognitive assessment- moca score ≥ 20) and/or communication impairments that don't allow patients to follow directions (i.e., deafness, aphasia, etc.); * patients who are receiving other related therapy through the study, which may affect efficacy of this study; * any medical contraindications to start rehabilitation; * history of disability related to neurological deficits other than stroke.

Keywords: rehabilitation motor learning balance mobility
gathering online for dialogue and discussion to enhance social support

Conditions: Alcohol Misuse; HIV; Sexually Transmitted Infections; Pre-exposure Prophylaxis

Summary: the goal of this trial is to test a modified mobile health intervention (with a group component) relative to a mobile health intervention in a two-arm randomized trial with 500 young african american women who are human immunodeficiency virus (hiv)-negative and who misuse alcohol. the expected outcomes are to: (1) determine the efficacy of the virtual group component in reducing alcohol use and sexual risk and increasing pre-exposure prophylaxis (prep) utilization; and (2) understand selected outcomes for implementation. participants will be randomized to receive either the mhealth app or the mhealth app plus the group component, and followed up at 3- and 6-months post-enrollment.

a total of 500 participants who are human immunodeficiency virus (hiv)-negative who engage in heavy alcohol use will be enrolled and referred to their local health departments for pre-exposure prophylaxis (prep). primary biobehavioral outcomes assessed will include reduced alcohol use (self-reported and biological, including phosphatidylethanol \[peth\]), increased prep uptake (self-reported and biological), and reduced sexual risk (self-reported condomless sex and impaired sex and biological testing for hiv) at 3- and 6-month follow-up.

Eligibility criteria:
selected inclusion criteria: * identify as black/african american * identify as female * be between 18 and 30 years old * recent substance use * hiv negative and not currently on prep * have an android or ios-based smartphone selected exclusion criteria: * test positive for hiv * participated in the previous study activities of the current study or previous related studies
developing a shared decision making tool for patients with surgically removed non-small cell lung cancer

Conditions: Lung Non-Small Cell Carcinoma

Summary: this study observes conversations between non-small cell lung cancer patients and their doctors to support the development of a decision aid that can be used to inform discussions about treatment options for after surgery. patients who have undergone surgery for their non-small cell lung cancer may have the option of completing additional treatment. patients contemplating this additional treatment have been shown to be most satisfied with their choice if they perceive an effort by their doctor to share decision making. shared decision making tools can help doctors guide conversations, offer tailored recommendations, and support deliberation on whether or not to pursue treatment. this study develops a shared decision making tool for patients with surgically removed non-small cell lung cancer contemplating additional treatment.

primary objective: i. to develop, in close collaboration with stakeholders, an evidence-based decision aid to inform discussions regarding options for adjuvant treatment in patients with resected non-small cell lung cancer (nscl) (nscl adjuvant choice). outline: patient and clinician discussions are observed to support refinement of a decision aid. clinicians may use a prototype of the decision aid in discussions with their patients and may complete a questionnaire.

Eligibility criteria:
inclusion criteria: * patients: * adults \>= 18 years with biopsy proven resected non-small cell lung cancer (nsclc) * appointments to discuss adjuvant treatment of resected nsclc * clinicians: * clinicians who meet with patients to discuss adjuvant treatment of resected nsclc * pag members: * adults \>= 18 years * member of the knowledge and evaluation research (ker) unit patient advisory group (pag) exclusion criteria: * patients * major barriers to providing informed consent (i.e., dementia, severe hearing or visual impairment)
a long-term study of alks 2680 in subjects with narcolepsy and idiopathic hypersomnia

Conditions: Narcolepsy Type 1; Narcolepsy Type 2; Idiopathic Hypersomnia

Summary: the purpose of this study is to continue to measure the safety, tolerability, and durability of treatment effect in subjects with narcolepsy type 1 (nt1) or narcolepsy type 2 (nt2) when taking alks 2680 tablets


Eligibility criteria:
inclusion criteria: * was eligible for and has completed end of treatment visit of alks 2680 eligible parent study in nt1, nt2 or ih. the current eligible studies are alks 2680-201 (vibrance-1), alks 2680-202 (vibrance-2) and alks 2680-203 (vibrance-3) * is willing and able, and in the opinion of the treating physician can safely discontinue any medications prescribed for the management of narcolepsy symptoms, as applicable, for 5 half-lives prior to day 1 (for re-entry subjects), and for the duration of study (for all subjects) exclusion criteria: * developed a new clinically significant health condition, ecg or laboratory abnormality, in the opinion of the investigator or sponsor, may impact the subject's participation in the study * is currently pregnant, breastfeeding, or planning to become pregnant during the study * is currently enrolled in another clinical study (other than the parent study) or used any investigational drug or device within 30 days prior to screening

Keywords: narcolepsy narcolepsy type 1 narcolepsy type 2 nt1 nt2 orexin-2 receptor agonist sleep sleep disorder excessive daytime sleepiness ih idiopathic hypersomnia