Kornimate/medical-research-clean huggingface dataset:
octylseal surgical adhesive in general surgery

Conditions: Wounds

Summary: the purpose of this study is to evaluate how surgical adhesive is used.

in this case series study, clinician experience and subject outcomes will be recorded in the use of a topical skin adhesive (octylseal) on the closure of skin incisions from general surgical procedures.

Eligibility criteria:
inclusion criteria: * candidate for use of a topical surgical skin adhesive exclusion criteria: * subjects with know sensitivity to topical surgical tissue adhesive products or degrading products (cyanoacrylates or formaldehyde) * subjects with a history of keloid formation, hypotension, insulin dependent diabetes mellitus, blood/clotting disorders, peripheral vascular diseases or hypertrophy history * subjects who present with a contraindications for product usage as per labeling * a wound with evidence of active infection or gangrene or wounds of decubitus etiology * mucosal surfaces or across mucocutaneous junctions or skin that might be exposed to bodily fluids or with dense natural hair * subjects with known hypersensitivity to cyanoacrylate or formaldehyde

Keywords: wounds
family-centred e-health in pediatric weight management: a pilot study

Conditions: Pediatric Obesity

Summary: this is a pilot study to examine the feasibility of implementing an objective physical activity and sleep monitoring tool into a pediatric weight management program in conjunction with a personal health record (phr) for children and their families. this feasibility study is intended to provide proof of concept in the incorporation of monitoring devices within the phr for pediatric patients and their families. additionally, the investigators will examine whether the phr helps to empower pediatric patients, their families and the health care team to more effectively monitor the patient's behavior change. participants will be randomized to receive, or not receive, augmented communication with the health care team between clinical in person visits.

lifestyle behaviour changes represent the foundation of pediatric weight management and are usually promoted through individual and/or group-based counseling to encourage the adoption and maintenance of health lifestyle behaviours including nutritional intake, sleep and physical activity. consensus on the need for comprehensive, behavioural interventions exists, but the nature of these interventions vary considerably. the intensity of the intervention (i.e. number of contact hours) may be a key determinant of efficacy, but little detail on the characteristic of these contact hours for optimal delivery is currently available. in this proof of concept study, we will evaluate the enhancement of behavioural change strategies utilizing technology that provides direct feedback on behaviour change. these devices will be incorporated into a phr and supplemented with a related e-learning module. this study will examine the feasibility and perceived usefulness of incorporation of a personal electronic device to encourage behaviour change in children and youth enrolled in a weight management program. we intend to incorporate this device within an established phr and supplement with evidence-based e-learning. this is a prospective, randomized pilot study of children and youth (ages 5-17 years) enrolled in a multidisciplinary pediatric weight management program (at mcmaster children's hospital) for 4 months. this pilot study will include 10 children/youth and parent dyads from each of 3 age groups: 5-9 years, 10-13 years and 14-17 years. all families will utilize a personal electronic device that they can utilize with the individualized phr. participants will be randomized to receive, or not receive, regular communication with and access to the clinical team outside of their routine clinical visits, this will occur through a secure portal in the phr.

Eligibility criteria:
inclusion criteria: * children/youth between the ages of 5-17 years * enrolled in pediatric weight management program at mcmaster children's hospital * provide informed written assent (child/youth) * provision of informed written consent (parent/caregiver) exclusion criteria: * no access to internet/home computer

Keywords: pediatric obesity e-learning personal health record personal electronic device pilot
stimulant abuser groups to engage in 12-step

Conditions: Drug Abuse

Summary: the purpose of this study is to determine whether a combined group and individual 12-step facilitative (tsf) intervention, stimulant abuser groups to engage in 12 -step (stage-12), improves substance -related outcomes.

this protocol is to evaluate the degree to which a combined group and individual 12-step facilitative (tsf) intervention, stimulant abuser groups to engage in 12 -step (stage-12), improves substance -related outcomes compared to treatment as usual (tau) without stage-12 among stimulant abusers. the primary objective is to evaluate reduction in percent of days of stimulant use as measured by self-report. secondary objectives include evaluating reduction in percent days of use of other substances, the degree to which stage-12 increases involvement in 12-step activities and attendance at 12-step meetings, and the extent to which such 12 -step involvement and meeting attendance mediate substance use outcomes.

Eligibility criteria:
inclusion criteria: * seeking outpatient treatment for stimulant abuse or dependence * current diagnosis of stimulant abuse or dependence * willing to participate in the protocol exclusion criteria: * not sufficiently medically or psychiatrically stable * pending legal action that would inhibit their participation in the study * in need of detoxification from opiates

Keywords: cocaine, methamphetamine, amphetamine, other stimulant drugs
the effect of laughter therapy on students in the covid-19 pandemic

Conditions: Laughter Yoga; Anxiety; Life Satisfaction; Psychological Well-being; COVID-19

Summary: this study was designed as a randomized controlled, pre-test-post-test control group in order to determine the effect of laughter therapy on anxiety, life satisfaction and psychological well-being of nursing students. laughter therapy was applied to the experimental group for at least 60 minutes, 10 sessions two days a week. for the evaluation, the state-continuity anxiety scale, life satisfaction scale, psychological well-being scale were applied at the pre-application stage (pre-test) and after the laughter therapy sessions (post-test). the following hypotheses were included in this study; h1: laughter therapy given during the covid19 pandemic reduces the anxiety level of intern students. h2: laughter therapy given during the covid19 pandemic affects the life satisfaction of intern students. h3: during the covid19 pandemic process, the laughter therapy given to interns affects the relationship between anxiety levels and life satisfaction. h4: laughter therapy given to intern students during the covid19 pandemic process affects psychological well-being.

today, all countries are struggling with covid-19, which typically presents with mild symptoms but causes serious mortality in the world population. in addition to the routine changes due to the pandemic, face-to-face education has been switched to online education. the integration of online education and more technology into the curriculum than ever before has increased students' anxiety towards learning. it was also found to cause high levels of anxiety and stress, characterized by feelings of risk, insecurity, and unhappiness. studies show that high levels of anxiety negatively affect students' adaptation to daily life and their life satisfaction levels. in recent years, non-pharmacological techniques have been widely used in reducing anxiety and stress. one of them is laughter therapy. laughter therapy reduces feelings of negative stress, anxiety, and depression by increasing the body's readiness to deal with different types of problems. the aim of this study is to examine the effects of online laughter therapy on anxiety, life satisfaction and psychological well-being levels of nursing students, who have switched to online education during the pandemic process.

Eligibility criteria:
inclusion criteria: * a student of the faculty of health sciences, department of nursing and enrolled in the fall semester, * who has not studied laughter yoga before or did not do laughter yoga, * it will create students who agree to participate in the research. exclusion criteria: * being a foreign national, * having a situation where laughter yoga is not recommended (having surgery in the abdominal region in the last three months, uncontrolled hypertension, chronic cough, incontinence, acute back pain, acute mental disorders, consumption of antipsychotic drugs, glaucoma, hernia, epilepsy), * students with simultaneous participation in any complementary treatment methods will be excluded.
comparison of self-ligating mico one and conventional mbt brackets regarding alignment efficiency and pain experience- a randomized clinical trial

Conditions: Pain

Summary: the rate of orthodontic tooth movement affects the efficacy and time duration of the treatment. one of the key factors, during the initial alignment phase, is the amount of the force that the arch-wire applies to the dentition. the amount of the applied force and the rate of tooth movement are directly proportional to the frictional resistance between the arch wire and bracket. the quality and degree of resistance is related to the physical characteristics of the arch wire, bracket material, arch wire dimensions, and the type of arch wire ligation. the estimated rate of tooth movement is about 0.35 to 2.04 mm per month, which is influenced by various factors and variables including the biological response of the individual to orthodontic forces, the complexity of the case, treatment mechanics and patient compliance throughout the course of treatment .

to compare the alignment efficiency and pain experience of mico-one self-ligating and conventional ligating mbt pre-adjusted brackets in the initial alignment stage of patients undergoing orthodontic treatment.conventional mbt brackets: in conventional brackets elastic ligatures or metal ties are used to ligate the wire in the bracket slot. 2. self-ligating brackets: self-ligating brackets like conventional braces are placed relatively the same way. the exception is that self-ligating braces don't use elastics, or metal ties. instead it has special clips or brackets with a spring-loaded door. the brackets while maintaing pressure on the archwire, help move the teeth along it at a steady pace .\[9\] 3 .alignment efficiency movement of the teeth measured at four months interval. scoring method involves measuring the linear distance between anatomical contact points between maxillary and mandibular incisors from adjacent tooth anatomical points. (little's irregularity index) 4.pain unpleasant sensory and emotional experience associated with tooth movement will be measured as a mean using the vas at 4 hours, 24 hours, day 3, day 7, 1 st month, 2 nd month, 3 rd month and 4 th month.

Eligibility criteria:
inclusion criteria * patients with non extraction orthodontic treatment plan * crowding of 3 to 6 mm according to little's irregularity index * both male and female patients * 14-20 years of age. * all permanent teeth present up to first permanent molar exclusion criteria: * poor oral hygiene * systemic disease * patients with periodontally compromised teeth * patient requiring orthognathic surgery to correct skeletal discrepancies * patients taking medications, like nsaids or other anti-inflammatory drugs * cleft lip or palate * hypodontia, or hyperdontia

Keywords: alignment efficiency and pain experience
a phase 2 study to evaluate the efficacy and safety of vir-2482 for the prevention of illness due to influenza a

Conditions: Influenza A

Summary: the purpose of this study is to evaluate the efficacy, safety, and tolerability of vir-2482 compared to placebo in preventing influenza a illness in healthy adults 18 to \<65 years of age without pre-existing risk factors for serious complications from influenza infection.


Eligibility criteria:
inclusion criteria: * participant must be 18 to \< 65 years of age, at time of randomization * participants must be in good health, determined from medical history and no clinically significant findings from physical examination, 12-lead electrocardiogram (ecg), vital signs, and laboratory values exclusion criteria: * history or clinical evidence of conditions considered high risk for developing influenza-related complications * history of confirmed influenza infection within 3 months prior to randomization. * febrile illness with or without respiratory symptoms * history of malignancy within 5 years or participant is under evaluation for malignancy. * any condition or receipt of any medication contraindicating im injection, as judged by the investigator. * history of a severe allergic reaction with generalized urticaria, angioedema or anaphylaxis * participant has a clinically significant medical condition, physical exam finding, or abnormal laboratory result. * prior or planned receipt of any influenza vaccine for the upcoming season. * received any investigational agent within 90 days or within 5 half-lives of the investigational agent.

Keywords: flu
effect of electrostimulation in chronic obstructive pulmonary disease (copd)

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this study was designed to test the following hypothesis: to investigate whether copd muscles can respond to stimuli in terms of changes in fiber-type distribution.

background: muscle dysfunction is a major problem in chronic obstructive pulmonary disease (copd). it is characterized by muscle fiber-type redistribution and oxidative stress. classical training does not improve these features. objectives: to investigate whether electrostimulation program following exacerbation can modify muscle structure and function in copd patients. method: we propose to conduct a controlled and randomized clinical trial comparing the efficacy of muscle electrostimulation training of the lower limbs to sham training in 15 patients with copd. patients are included in either 6 weeks of electrostimulation training (active treatment group) or 6 weeks of sham electrostimulation. primary outcomes were changes in muscle structure, muscle oxidative stress and their relationship with quadriceps force and exercise tolerance.

Eligibility criteria:
inclusion criteria: * copd patients during or after exacerbation exclusion criteria: * comorbidities that could limit exercise training * obesity (body mass index \[bmi\] \> 30 kg/m²) * neuromuscular disease * pacemaker implantation

Keywords: copd
oral ivermectin for chikungunya viral infection

Conditions: Clinical Syndrome

Summary: chikungunya viral infection (cvi) is a mosquito-borne infection, caused by chikungunya virus (chikv), an alphavirus, belonging to the family togaviridae. this infection causes febrile illness associated with high fever, rash, acute deliberating and persistent arthralgia. there is no licensed vaccine or specific treatment for this infection. ivermectin (ivm), commonly-used antiparasitic, has been demonstrated to inhibit replication of chikv.


Eligibility criteria:
inclusion criteria: * patients with virologic confirmation of chikungunya infection who had symptoms less than 72 hours prior to visit exclusion criteria: * patients with virologic confirmation of chikungunya infection who had symptoms more than 72 hours prior to visit
ultraviolet radiation forecasting based heliotherapy for psoriasis in bangkok, thailand

Conditions: Psoriasis Vulgaris

Summary: due to limited number of phototherapy centres and shortage of qualified phototherapy practitioners, heliotherapy has become a promising treatment alternative in thailand where patients effortlessly receive supervised sun-bathing treatments from their homes whenever they are convenient. we used newly designed deep neural network uv forecasting model developed by using our 10 year-retrospective solar uv irradiance (280-400 nm) retrieved from a ground based platform at atmosperic laboratory, silpakorn university, nakhon pathom, thailand (13.82n 100.04e, 30 m above mean sea level). this model achieved a next-day forecast error of less than 12% which has been the most accurate prediction to date. we designed our 10week heliotherapy regimen based on the predicted anti psoriasis effective irradiance values. we studied efficacy and safety of the 12-week heliotherapy regimen for psoriasis on only ruled acceptable clear sky days in bangkok, thailand

we studied efficacy and safety of the 16-week heliotherapy regimen for psoriasis on only ruled acceptable clear sky days in bangkok, thailand

Eligibility criteria:
inclusion criteria: * a psoriasis patient who indicate to have phototherapy and have lesional plagues systemically either on the front-back or left-right. * a participant is based in bangkok * a participant is capable to understand and learn how to use our in-house assembled uv metre and web-based heliotherapy platform. exclusion criteria: * a participant has any sun-sensitive conditions including photo-aggravated photodermatoses and on photosentisitive drug treatments. * breast-feeding, pregnant individuals.

Keywords: heliotherapy sun-bathing psoriasis ultraviolet radiation forecasting thailand
foot/ankle at 7t mri

Conditions: Plantar Plate Tear

Summary: * to evaluate standard clinical sequences for 7 tesla mri of the foot and/or ankle to improve detailed depiction of the complex anatomy of this region. * to evaluate various pathologies of the foot and/or ankle (plantar plate tears, morton neuroma, tendon tears, ligament tears etc.).


Eligibility criteria:
inclusion criteria: * informed consent as documented by signature (appendix informed consent form) * at least 18 years old * study group: patients with specific pathologies (i.e. morton neuroma, tendon tears, plantar plate tears) as proven by 1,5 or 3t mri or asymptomatic subjects (to look at the normal microanatomy of different structures, mainly the plantar plate) * control group: no evidence of the respective pathology. exclusion criteria: * previous foot surgery with metal in vivo * pregnancy or breast feeding * any mri contra-indications
the effect of exercise on physical function and health in older people after discharge from hospital

Conditions: Chest Pain; Pneumonia; Transient Ischemic Attack; Stroke; Functional Failure

Summary: the aim of this study is to investigate the effect of a multi-component exercise program on physical function, physical activity and health-related quality of life (hrqol) in older people recently discharged from hospital. the intervention consists of 32 group-based exercise sessions, performed twice a week. in addition the participants in the intervention group will be encouraged to perform an exercise program on their own, at least once weekly. the participants in the control group will be encouraged to exercise on their own, according to the world health organization (who) recommendations on physical activity for adults aged 65 and above.

older people who have been hospitalized often experience loss of function, increased risk of falls and reduced health-related quality of life (hrqol) in the post-discharge period. the reason for this is the cumulative effect of illness, bedrest during hospital stay and inactivity after discharge. previous research indicates that exercise therapy should be an integrated part of the post-hospital treatment to prevent or postpone this functional decline and improve hrqol. therefore, the investigators will conduct a randomized controlled trial to investigate the effect of a multi-component exercise program consisting of high intensity exercises on physical function, physical activity and hrqol among older people living at home after discharge from hospital after treatment of an acute medical event.

Eligibility criteria:
inclusion criteria: * 65 years or older, live in their own home, consent to participate in the program three times a week (twice a week outside their home), manage to walk with or without assistive device, and assessed by a doctor as able to tolerate the intervention. exclusion criteria: * severe cognitive impairment (mini-mental state examination (mmse) score less than 20), have an expected lifespan less than one year, exercise more than twice a week, and score above nine points on the short physical performance battery.
real-world betaseron health economic outcomes study for relapsing forms of multiple sclerosis

Conditions: Multiple Sclerosis, Relapsing-Remitting

Summary: a web based real world observational study in relapsing-remitting multiple sclerosis (rrms) population capturing outcomes reported by patients and by the physicians during 12 months after initiating or resuming betaseron.


Eligibility criteria:
inclusion criteria: * provides written informed consent to participate in the study * at least 18 but no more than 65 years old * documented clinical diagnosis of a relapsing form of multiple sclerosis or confirmed clinically isolated syndrome (cis) * initiating betaseron therapy, or resuming betaseron after not having used it for at least three months * willing and able to provide a valid e-mail address which will be in use for the duration of the study * willing and able to complete study questionnaires via the internet * has reliable internet access for the duration of the study * completes the baseline patient questionnaire exclusion criteria: * kurtzke expanded disability status scale (edss) score greater than 6.0 * cognitive dysfunction that, in the investigator's judgment, raises doubts about the study participant's ability to provide informed consent or accurately complete the monthly patient questionnaire * any use of betaseron within the three months prior to study entry * inability to read, write, or speak the english language * illness or disease other than multiple sclerosis that the investigator believes is likely to cause the patient's death or incapacity within twelve months * any severe, uncontrolled illness or condition that the investigator believes could dominate the patient's quality of life * coexistent autoimmune disease such as rheumatoid arthritis, lupus, or psoriasis that is likely to be exacerbated by treatment with interferon * current use of any immunosuppressive medication * previous participation in a multiple sclerosis (ms) clinical trial within the three months prior to study entry * previous use of monoclonal antibodies treating ms within the three months prior to study entry * current use of any secondary treatment for multiple sclerosis other than the episodic use of steroids during relapses or exacerbations

Keywords: outcomes real world and web tool electronic data capture
inspace™ system in comparison to best repair of massive rotator cuff tear

Conditions: Rotator Cuff Tear

Summary: this is a post-marketing study to further assess the safety and effectiveness of the inspace™ device implantation in comparison to surgical repair of full thickness massive rotator cuff tear .

the effectiveness will be assessed by comparing the scores of the ases, constant and quick dash outcome questionnaires with respect to pain reduction, improvement of activity of daily living (adl) and improvement of range of motion (rom).

Eligibility criteria:
main inclusion criteria: * age 40 or older. * positive diagnostic imaging of the affected shoulder indicating full thickness massive rct (according to cofield classification) or long involving more than one tendon. * persistent pain and functional disability of the affected shoulder for at least 3 months. main exclusion criteria : * known allergy to the balloon material (copolymer of pla and -θ-caprolactone). * evidence of significant osteoarthritis or cartilage damage in the shoulder * evidence of gleno-humeral instability * previous surgery of the shoulder in the past 2 years, excluding diagnostic arthroscopy * evidence of major joint trauma, infection, or necrosis in the shoulder * partial-thickness tears of the rotator cuff

Keywords: massive rotator cuff tear sub-acromial spacer best repair of rotator cuff