Kornimate/medical-research-clean huggingface dataset:
single dose partial breast radiotherapy

Conditions: Breast Cancer

Summary: this study seeks to determine the maximum tolerated dose of a single-dose partial breast radiation given before lumpectomy using a radiosurgery technique. lumpectomy will be performed within 3 weeks (+/- 1 week) of completing radiation.

this study will assess the safety of partial breast radiosurgery as measured by the incidence of acute toxicity and wound healing complications in three dose cohorts. patients will be enrolled in cohorts of 8 patients starting at dose level 1 (15 gy). if 2 or more dose limiting toxicities (dlts) are observed at dose level 1, the trial will be stopped for evaluation and consideration of revision. if at most one dlt is observed then escalation continues to the next dose level. the cohorts will escalate by 3gy up to 21 gy of irradiation.

Eligibility criteria:
inclusion criteria: * women with a biopsy proven diagnosis of low/intermediate grade ductal carcinoma in situ or invasive ductal (or other favorable histology) carcinoma of the breast * breast preservation candidates (no prior breast or nodal radiotherapy, no imaging evidence of multicentric or multifocal disease, no pregnant women, and no comorbid conditions precluding surgery) * clinical t1n0m0 * 55 years of age or older * estrogen receptor (er) positive, * no evidence of lymphovascular space invasion on initial biopsy * not pregnant. if not post-menopausal must adhere to birth control measures * white blood cell count \> 3000, hemoglobin \> 9, platelets \>100000 * must be eligible for mri on initial evaluation and gfr at least 60 ml/min exclusion criteria: * neoadjuvant chemotherapy * breast implants * medical conditions that may increase risk for poor cosmetic outcome (i.e. lupus, rheumatoid arthritis, scleroderma) * patients unable to receive study treatment planning secondary to body habitus or inability to lie flat on the stomach at length * her-2/neu positive * positive serum pregnancy test

Keywords: cancer of breast cancer of the breast neoplasms, breast single dose radiation radiotherapy preoperative
effects of neural flossing and pnf on lumbar radiculopathy

Conditions: Lumbar Radiculopathy

Summary: the goal of this clinical trial is to determine the effects of neural flossing with and without proprioceptive neuromuscular facilitation on pain, range of motion and disability in patients with lumbar radiculopathy. the main question it aim to answer is :- does proprioceptive neuromuscular facilitation added benefit when combined with neural flossing to pain, range of motion and disability in lumbar radiculopathy patients? research will compare the neural flossing group with the group receiving neural flossing with proprioceptive neuromuscular facilitation to see if there is any difference in the outcomes.

lumbar radiculopathy is a mutual condition amongst persons presenting to a spinal physician for consultation. lumbar radiculopathy is a term used to describe the pain that is started in low back and radiated along the nerve root. the patient mostly complains from a low back pain that radiates toward the legs. symptoms may include radiating pain, weakness, hypo-reflexia and gait abnormalities. the pain is caused by the neurological manifestations of a compressive force along a specific nerve route. the main cause of radiculopathy is compression or irritation of nerve root exited from spinal cord. lumbar radiculopathy can affect anyone regardless of their age, gender, race and geographical locality. about 40% people developed low back pain at some points in their life and out of them 3-5% population developed lumbar radiculopathy. a study conducted to find out the influence of nerve flossing technique on acute sciatica and hip range of motion with sample size of 32. it was concluded that as a result of nerve flossing technique since no statistically significant changes occurred between the two groups. hence, for effective reduction of sciatic pain and possible improvement in hip range of motion, nerve flossing technique should be combined with conventional physiotherapy. a study conducted on mobilization of neurodynamic system using proprioceptive neuromuscular facilitation (pnf) decrease pain and increase mobility in lower extremities and spine suggested that pnf based rehabilitation approach results in improvement of pain, nerve mobility and balance.it also has positive effects by supplying oxygen to nerve, increase nerve mobility and decrease pain. some studies have been done testing the effects of neural flossing technique and pnf techniques individually as a treatment option for lumbar radiculopathy. but, up to the researcher's knowledge there is little literature on comparing both treatments with respect to pain, range of motion and disability in lumbar radiculopathy.

Eligibility criteria:
inclusion criteria: * age between 35-50 years. * both males and females. * pain intensity is 4 out of 10 on numeric pain rating scale. * history of radiculopathy for more than 3 weeks. * pain radiating below to knee. exclusion criteria: * cognitive impairment. * using pain modulating medicines. * patients with comorbidities. * pain radiating above to knee.

Keywords: disability lumbar pnf neural flossing pain
cranberry juice for the prevention of recurrent urinary tract infections

Conditions: Urinary Tract Infections

Summary: this study will determine whether cranberry juice is effective in reducing recurrent urinary tract infections (utis) in women who have had a uti within the past year.

utis are a common problem among young women, resulting in considerable morbidity and health care costs. increasing resistance to antibiotics is making treatment of these infections even more problematic. therefore, safe and effective nonantimicrobial prevention strategies are needed. one approach that appears to be effective is the use of cranberry products. however, data on the safety and effectiveness of cranberry products are limited. this study will determine whether cranberry juice can reduce utis in women. participants will be randomly assigned to receive either cranberry juice or a placebo drink daily for 6 months. study visits will occur every month for the 6-month treatment phase of the study. at study entry and at each study visit, urine collection will occur and vaginal swabs will be taken. a rectal swab will be taken at study entry and at the month 2 and 4 visits. participants will be asked about medication usage, any side effects they may be experiencing, and diet at each study visit. if participants develop a uti at any time during the study, they will be asked to visit the study site within 24 hours.

Eligibility criteria:
inclusion criteria: * at least one uti within 12 months prior to study entry * premenopausal * agree to avoid all foods that contain plants from the genus vaccinium (related to cranberries) for the duration of the study exclusion criteria: * anatomic abnormalities of the urinary tract * history of kidney stones * bacteria in the urine (bacteriuria) * use of prophylactic antibiotics within 7 days prior to study entry * use of investigational drugs within 30 days prior to study entry * current use of warfarin * diabetes * cancer. participants with skin cancer are not excluded. * allergy or intolerance of cranberry products * symptomatic vaginitis * pregnant or breastfeeding

Keywords: vaccinium macrocarpon cranberry complementary therapies
smart protocol vs antagonist protocol in ivf

Conditions: Diminished Ovarian Reserve

Summary: this retrospective study aims to assess the effect of adding letrozole in patients who have previously undergone an ivf cycle with either an antagonist or short protocol, with patients who have undergone a second cycle of ivf with an antagonist or short protocol without the addition of letrozole.

a limited number of studies suggest that the addition of letrozole to gonadotropins for ivf is associated with an increase in oocyte count, blastocyst count and implantation rate. these differences are presumed to be caused by an increase in intra-ovarian androgens associated with the addition of letrozole. in patients with reduced ovarian reserve or reduced oocyte quality in the previous cycle, supplementation with of letrozole has the potential to increase oocyte count or oocyte quality, thereby resulting in more transferable blastocysts. the antagonist stimulation protocol with the addition of letrozole is commonly referred to as the smart protocol (stimulation with minimal adverse effects, retrieval and transfer

Eligibility criteria:
inclusion criteria for the smart ivf protocol: * women between the ages of 20 and 42 inclusively * women proceeding with a smart ivf protocol following an antagonist ivf protocol between 2010 and 2020 (study group) or women proceeding with an antagonist protocol following an antagonist ivf protocol between 2010 and 2020 (control group) * delay of 1 year between both ivf cycle exclusion criteria: * women undergoing fertility preservation * oocyte donation ivf cycles * diagnosed severe male factor requiring surgical sperm extraction (micro-tese or tesa)

Keywords: ivf fertility issues
ventilation with high oxygen content and postoperative pneumocephalus

Conditions: Pneumocephalus

Summary: the aim of this study is to compare the incidence and volume of postoperative pneumocephalus in patients receiving ventilation with 100% oxygen during the last stage of surgery versus a conventional 1:1 oxygen/air gas mixture.

background: postoperative pneumocephalus is a common complication in patients undergoing craniotomies. even though the treatment of postoperative pneumocephalus with the use of supplemental oxygen is well documented, yet not reports have shown its role for the prevention of this condition. we suggest the use of intraoperative ventilation with 100% oxygen as prophylaxis for the incidence and severity of postoperative pneumocephalus in patients undergoing intracranial surgery. objectives: the aim of this study is to compare the incidence and volume of postoperative pneumocephalus in patients receiving ventilation with 100% oxygen during the last stage of surgery versus a conventional 1:1 oxygen/air gas mixture. study methods: a single-blinded, prospective study, randomizing 80 patients per group, expecting 80% power to detect a 20% decrease in pneumocephalus volume for the interventional group. inclusion criteria: patients \>18 years, scheduled to undergo elective craniotomy, and be willing to give written informed consent. study procedures: once the tumor resection is completed and hemostasis started (beginning of stage 2), patients will be assigned to receive either 1:1 oxygen/air gas mixture (control group) or 100% oxygen (intervention group) until the end of the surgery. all patients will receive postoperative supplemental oxygen via nasal cannula. ct scan will be performed within 1 to 6 postoperative hours as standard of care. a blinded radiologist will review all ct scans and assess the extent and frequency of postoperative pneumocephalus. clinical outcomes: patients' demographic data, length of stage 2, period of time between the end of surgery and ct scan, and pneumocephalus volumetric measurements will be compared between groups. baseline neurological status will be compared with clinical and imaging postoperative findings.

Eligibility criteria:
inclusion criteria: * patients \> 18 years of both sexes undergoing surgical procedures to treat hemispheric or posterior cranial fossa tumors and consenting to the study exclusion criteria: * history of severe cardio-pulmonary disease. * bleeding disorders * previous neurosurgeries requiring cranial reconstruction * head trauma * decreased consciousness related to cerebral edema

Keywords: postoperative pneumocephalus fraction of inspired oxygen intracranial surgery
combination chemotherapy before surgery in treating children with localized neuroblastoma

Conditions: Neuroblastoma

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed during surgery. purpose: phase iii trial to determine the effectiveness of combination chemotherapy given before surgery in treating children who have localized neuroblastoma.

objectives: * determine the outcome, in terms of local control, event-free survival, and overall survival, of children with localized unresectable neuroblastoma without mycn amplification treated with carboplatin, etoposide, cyclophosphamide, doxorubicin, and vincristine followed by surgery. outline: this is a multicenter study. patients receive carboplatin iv over 1 hour and etoposide iv over 2 hours on days 1-3 (courses 1 and 3). patients receive cyclophosphamide iv over 1 hour on days 1-5 (or orally on days 2 and 3), doxorubicin iv over 6 hours on days 4-5, and vincristine iv on days 1 and 5 (courses 2 and 4). treatment repeats every 21 days for 4 courses. patients then undergo surgical resection followed by 2 additional courses of chemotherapy. patients are followed at months 8, 10, 12, 16, 20, 24, 30, 36, 42, 48, and 60. projected accrual: a total of 100 patients will be accrued for this study within 4 years.

Eligibility criteria:
disease characteristics: * diagnosis of localized unresectable neuroblastoma * stage ii or iii * no mycn amplification patient characteristics: age: * over 1 performance status: * not specified life expectancy: * not specified hematopoietic: * not specified hepatic: * not specified renal: * not specified prior concurrent therapy: biologic therapy: * not specified chemotherapy: * no prior chemotherapy endocrine therapy: * not specified radiotherapy: * no prior radiotherapy surgery: * not specified

Keywords: localized unresectable neuroblastoma
the correlation between blood omega3 and adhd

Conditions: Attention Deficit Hyperactivity Disorder (ADHD)

Summary: attention deficit hyperactivity disorder (adhd) is a major problem in children and adolescents. clinical and biochemical evidence suggests that deficiencies of polyunsaturated fatty acids (pufa) could be related to adhd. pufas are the major components of brain with important physiologically active functions. aim: study the relationship between omega3 blood values and adhd clinical status. methods: the investigators will recruit 30 children, who have been diagnosed with adhd by a child psychiatrist. in addition the investigators will recruit a control group of 30 children without adhd and related neuropsychiatric syndromes. blood will be taken from all children. the adhd children will be asked to consume omega3 capsules for 6 month. after 3 and 6 months, all children will undergo clinical examination and blood tests will be taken for omega3 index analysis. blind frozen samples of isolated red blood cell (rbc) will be analyzed according to the omega3 index methodology.

attention deficit hyperactivity disorder (adhd) is a major problem in children and adolescents. clinical and biochemical evidence suggests that deficiencies of polyunsaturated fatty acids (pufa) could be related to adhd. pufas are the major components of brain with important physiologically active functions. aim: to investigate influence effects of omega3 dietary supplementation on adhd symptoms and the measured blood values. methods: the study will be authorized by the ziv helsinki committee and the ministry of health. written informed consent will obtained from parents. the investigators will recruit 30 children, who have been diagnosed with adhd by a child psychiatrist. in addition the investigators will recruit a control group of 30 children without adhd and related neuropsychiatric syndromes. blood will be taken from all children.

Eligibility criteria:
inclusion criteria: - adhd group: children diagnosed with adhd aged 6-14; children who have not received a dietary supplement of omega3 in the last month control group inclusion criteria: children without adhd and related neuropsychiatric syndromes aged 6-14, children who have not received a dietary supplement of omega3 in the last month. exclusion criteria: - children with severe chronic or autoimmune disorders, children who received a dietary supplement of omega3 in the last month

Keywords: adhd omega3
effectiveness of knowledge by video and handbook of liver cancer patients with first trans-arterial chemoembolization

Conditions: Cancer

Summary: objective: to compare the effectiveness between video and handbook on providing knowledge of tace. study design: a prospective, randomized, controlled trial.

background : liver cancer is a serious disease with a high death rate. one of the treatment modalities for liver cancer is tace. patients always scare of the first tace due to their lack of knowledge and inadequate comprehension of the procedure. hence, they crave to have a good quality in nursing service. researcher would like to compare the effectiveness knowledge between video and handbook regarding patients' health education. objective: to compare the effectiveness between video and handbook on providing knowledge of tace. study design: a prospective, randomized, controlled trial. setting: chulabhorn hospital, bangkok, thailand. methods : eighty liver cancer patients are included in the study. they are systematically computerized and randomized into two groups - an experiment or video group (n 40) and a control or handbook group (n = 40). a 40-item exam is performed to test the patients' knowledge before (x score), after (y score) and 60 days (z score) after the procedure. the 15-min study was taken in an isolated room. the points of interest are the effectiveness of medias on learning achievement and relative growth of knowledge. the relative growth of knowledge (g1, g2 score) was calculated as follows: g1 = 100 (y-x)/(f-x) % ; g2 = 100 (z-x)/(f-x)% retention of knowledge (r) = 100 - (g1 - g2) % where g = relative growth of knowledge r = retention of knowledge x = pre-test score y = post-test score z = final-test score f = total score

Eligibility criteria:
inclusion criteria: * age 20 - 75 years * willing to participate the study * 1st tace * can comprehend all information in video or handbook * no trouble of hearing * can complete the 40-item test exclusion criteria: * have psychological/mental problems

Keywords: knowledge [k01.468] video-audio media [v01.255.500] handbooks [v02.520]
comparison of em and sm+ maneuvers in patients with bppv

Conditions: BPPV

Summary: objective of this prospective randomized treatment trial is to compare the effectiveness of the semontplus (sm+) with the epley maneuver (em) for the therapy of posterior canal benign paroxysmal positional vertigo canalolithiasis (pcbppv).

bppv is the second most common form of vertigo. reported prevalence ranges from 10 to 140 per 100,000 and lifetime prevalence is at least 2.4%; prevalence of 9-11% have been found in a population older than 75 years. the leading symptom is recurrent attacks of spinning vertigo, each triggered by changes in position relative to gravity and lasting from seconds to one minute. the cause is usually freely moving otoconia in the posterior arcuate canal (so-called canalolithiasis); the horizontal canal is affected much less frequently. in 70% of patients there is a spontaneous remission within days. in case of persistence, about 95% of patients can be successfully treated with so-called freeing maneuvers, e.g., the sémont maneuver. however, this often requires 20 to 30 maneuvers over several days. based on 1. our own biophysical studies, which we performed together with colleagues from switzerland on a mechanical model of positional vertigo and which show that theoretically 24 the effectiveness of the sémont maneuvers can be increased by changing the positional angle by 30° in the so-called step two of the positional maneuvers, as well as 2. an analysis of the comparison of the conventional sémont maneuver with the so-called sémontplus maneuver, which shows that the mean time to freedom from symptoms for the sémont maneuver is 3.9 days and only 2.3 days for the sémontplus maneuver (p\<0.05), the efficacy of the epley maneuver will be compared with the semontplus maneuver in a parallel group design. the primary endpoint is the duration, i.e., days ("mornings") until freedom from symptoms with continuation of the two maneuvers in the following days, three times in the morning, at noon and in the evening. this is assessed by the patient's statements that he/she can still induce rotational vertigo or not during the positioning maneuvers to the affected side performed by him/herself.

Eligibility criteria:
inclusion criteria: * subject (≥ 18 years of age) meets diagnostic criteria for the current presence of bppv of a posterior arcuate duct (8): history: rotary vertigo attacks triggered by head or body position change. duration: \< 1 minute, associated with nausea, vomiting, oscillopsia findings: when positioned to the affected ear: torsional and vertically to the forehead beating, exhaustive nystagmus with crescendo-decrescendo-like course. exclusion criteria: * subjects not capable of giving consent * respondent does not want therapy for bppv

Keywords: benign paroxysmal positional vertigo semontplus maneuver epley maneuver
research of new serological markers for the diagnosis and monitoring of candidaemia in hospitalized patients

Conditions: Candida Infection

Summary: bloodstream infections due to candida spp remain a serious medical challenge because of their high incidence and poor outcome. diagnosis and monitoring of patients are still problematic, hindering efficient clinical management of the disease. the invastigators propose here to perform a retrospective study in a clinically well-characterized candidemic patient, with the goal of recognizing host immunological factors and virulence-associated fungal molecules relevant in the onset and evolution of infection. the researchers' ultimate goal is to identify new diagnostic and/or prognostic benchmarks useful in clinical settings. by combining serologic and immunologic expertise with clinical expertise, the research team has real potential to generate new markers of host pathogenesis and immune response in candidemia and to inform prospective clinical trials to control this terrible disease


Eligibility criteria:
inclusion criteria: * patients hospitalized * one or more positive blood cultures for candida spp, * positive beta-glucanemia * the presence of at least one clinical symptom of infection will be considered cases of candidemia. exclusion criteria: * age less than 18 years * state of immunosuppression * incompleteness of clinical data * unavailability of serum samples in sufficient quantities for analysis and in good condition.