Kornimate/medical-research-clean huggingface dataset:
gait adaptability: tracking locomotor recovery after incomplete spinal cord injury

Conditions: Gait Disorders, Neurologic; Gait Disorder, Sensorimotor

Summary: adaptive gait assessements will be evaluated as a potential new marker for tracking locomotor recovery throughout rehabilitation of spinal cord injury subjects. to this end, controls, subacute and chronic patients will be assessed at two timepoints with 3 month standard rehabilitation inbetween. the specific assessments will require the participant to acitvely modulate their gait pattern to fullfill specific task constraints. their performance will be assessed via 3d kinematics, kinetics and emg and these measures will be used to describe the adaptive capacity that the patient retains. sensitivity and specificity of these markers will be determined. with more sensitive descriptors of gait function and quality, locomotor rehabilitation for sci can be better designed and smaller effects can be accurately measured.


Eligibility criteria:
inclusion criteria: * informed consent as documented by signature (appendix informed consent form) * healthy controls * patients with an incomplete spinal cord injury in a chronic (at least 12 months post-injury) or subacute (3-6 months post-injury) stage of recovery * age: 18 years and older * able to stand without physical assistance and handrails for more than 120s * preserved segmental and cutaneo-muscular reflexes in the lower limbs * bodyweight over 20 kg and under 120 kg * mini-mental state examination score 26 (test only performed if cognitive deficits are suspected) exclusion criteria: * current orthopedic problems * neurological impairment other than sci * premorbid major depression or psychosis * metal implants in the cervical skull * history of significant autonomic dysreflexia with treatment * dermatological issues (e.g. decubitus) at the harness attachment site (back, abdomen, upper legs) * malignant diseases * heart insufficiency nyha iii-iv * potential pregnancy * unlikely to complete the intervention or return for follow-up * participation in another training study * contraindications for training using the grail (according the manual)
supportive cancer care networkers (scan)

Conditions: Colorectal Cancer; Chemotherapy

Summary: aim of the study is to increase the proportion of indicated patients with colorectal cancer undergoing adjuvant chemotherapy following surgical resection through an optimized symptom management and logistical support.

patients with colorectal cancer in germany today are exposed to several problems related to care continuity and access to health care professionals. in order to increase the utilization of adjuvant therapies, patients in the intervention group are offered an additional nursing intervention in the period between discharge after inpatient treatment and the beginning of adjuvant therapy. this includes a telephone follow-up conducted according to guidelines serving to disclose patients' current supportive needs in order to determine potential intervention approaches as early as possible. hence, the intervention aims to motivate patients not to discontinue the treatment. an early detection of therapy-related physical and psychological impairments aims at optimizing treatment management. patients in the intervention group therefore are visited by nursing staff specialized in cancer care (supportive cancer care networkers, scan) during their in-patient stay and are informed about the intervention. an assignment for the scan is to support patients in getting access to health care services (e.g. specialists). patients are given certain information, as for example contact to specialists, voluntary services and the next steps and appointments of the treatment plan are discussed. within a consultation at the day before hospital discharge, the scan takes up the contact information and appoints weekly telephone consultations for the time up to the adjuvant therapy. the scan hands out information materials and explains the study documents, as for example patient-held records (phr) in order to improve therapy compliance.

Eligibility criteria:
inclusion criteria: * colorectal carcinoma (icd-10: c18, c19, c20) * indication for adjuvant chemo therapy following s3-guideline on colorectal cancer or physician-directed * living in saxony-anhalt * ecog-performance status \<3 * prospective further life expectancy of more than three months exclusion criteria: * unable to read or understand german properly * any contra-indication for adjuvant therapy as described in the s3-guideline such as inadequate liver, bone marrow, and kidney function or coronary heart disease (nyha iii-iv).

Keywords: colorectal neoplasms/*drug therapy/*secondary health services accessibility humans supportive care needs psychooncology rural population primary health care/*methods treatment outcome socioeconomic factors quality assurance, health care quality of life adult aged aged, 80 and over
music listening for wellbeing in adults with acquired visual impairment

Conditions: Visual Impairment; Low Vision; Depression; Anxiety; Stress; Emotional Adjustment

Summary: a visual impairment (vi) is often associated with reduced psychological wellbeing. music can be used in a variety of ways to promote psychological wellbeing. music intervention studies demonstrate that listening to music can provide a distraction from unpleasant thoughts/feelings. hence, music may serve as a catalyst to improve mood and relieve feelings of depression, anxiety, and stress. the purpose of this study is to investigate if it is feasible for people with acquired vi to self-deliver daily music listening (music alone or with mindful music listening instructions) for wellbeing, in participants homes, for four-weeks, and to collect data remotely on efficacy in reducing symptoms of anxiety and depression and treatment fidelity.

detailed description: as part of the study participants will be asked to: * listen to music online at home (for example streaming music using apple music, spotify or the provider participants have an existing account with) for up to one-hour each day, five days a week for four-weeks. * complete a listening diary log each day (10 minutes duration approximately). this provides an opportunity for participants to record their feelings and emotions after every listening exercise. * complete surveys to capture evaluative information before and after the four-weeks music listening trial. * part take in a series of one-to-one consultations via zoom/ms teams (video optional) on creating a personalised playlist for each participant, technical and instructional training and follow up progress. * optional one-to-one interview via zoom/ms teams (video optional) on feedback and experience of this daily music listening research study (10 minutes duration approximately).

Eligibility criteria:
inclusion criteria: * age 18+ * have an acquired vision loss (someone who was not born with vision loss but lost part or all of their vision later in life) * have an existing account on a online streaming platform to listen to music * own a smartphone/tablet or technology that supports their music streaming platform * have the capacity to consent * have at least mild symptoms on the depression anxiety stress scale (dass-21) screening questionnaire; depression (score: 10 or higher on a scale 0-28+) and/or anxiety (score: 8 or higher on a scale 0-20+) and/or stress (score: 15 or higher on a scale 0-34+) exclusion criteria: • anyone who has a hearing impairment that renders the individual unable to listen to music or mindfulness instructions and follow a conversation on the telephone.
the cognitive and cardiovascular health in the elderly study

Conditions: Cognitive Diseases

Summary: the main objective of this study is to look for the interest forecast of the ips as infra-clinical cardiovascular marker in the prediction of a change of the cognitive functions (mci) at the elderly of 70 and more years old without clinical cardiovascular pathology.


Eligibility criteria:
inclusion criteria: * free-living community-dwelling men and women aged ≥ 70 years, * subjects free of clinical cvd related to atherosclerosis * preserved basic activities of daily living (adl = 6) * without cognitive impairment (mmse≥24) exclusion criteria: * subjects with clinical history of any of the following cvd diseases : coronary artery disease (angina, myocardial infarction, coronary revascularization), cerebrovascular disease (stroke, tia, carotid revascularization), clinical peripheral artery disease (claudication, critical limb ischemia) * subjects with neurodegenerative, locomotor and ophtalmological diseases unable to perform the cognitive tests * subjects unable to give written informed consent.

Keywords: alzheimer, cognitive diseases, ankle-to-brachial index
assessment of regenerative potential of mature permanent teeth with necrotic pulps using two revascularization protocols. (in vivo study)

Conditions: Apical Periodontitis

Summary: regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. thevaim of this study is to assess the regenerative potential of mature permanent teeth with necrotic pulps with platelet-rich fibrin (prf) and blood clot using radiographic and clinical methods.


Eligibility criteria:
inclusion criteria: * patients with mature teeth. * patients with periapical periodontitis. * maxillary anterior teeth only will be involved. * patients should be free from any systemic disease that may affect normal healing and predictable outcome. * patients who will agree to the consent and will commit to follow up period. exclusion criteria: * patients with immature roots. * patients with any systemic disease that may affect normal healing. * patients with swelling. * pregnant females. * patients who could/would not participate in a 1 year follow up. * patients with fistula. * patients with old age. * teeth with periodontal involvement. * teeth with vertical root fractures. * unrestorable teeth.
effect of electroconvulsive therapy on retinal nerve fiber layer thickness in depression

Conditions: Depression

Summary: the aim of this study is to investigate the changes in the retinal nerve fiber layer thickness of the patients with depression who received electroconvulsive therapy by means of optical coherence tomography.

major depression (md) is a mood disorder that is common in the society, has negative effects on emotion, thought and behavior, and leads to significant impairments in functionality. electroconvulsive therapy (ect) is a highly effective and reliable biological treatment method used in psychiatric diseases for a long time. the most common use in psychiatry is depression. studies have shown that ect causes a broadly distributed increase in brain gray matter volume (especially the temporal lobe) in md patients. optical coherence tomography (oct) is a non-invasive medical imaging method that displays biological tissue layers by taking high resolution tomographic sections. alterations in the thickness of the retinal nerve fiber layer (rnfl), which is a layer of the ganglion cell complex in the retina of the eye and consists of ganglion cell axons, occur due to axonal damage in the retinal nerve tissue. since rnfl is in a similar form with the brain gray matter tissue, recently, neurological and psychiatric studies have been conducted to provide data regarding the neurodegeneration occurring in the brain tissue. in the study, it is aimed to assess the possible cortical volume changes of patients by measuring changes in the retinal layers due to ect in patients with depression. in other words, considering that ect causes an increase in brain volume, it is to observe whether this increase is reflected in the retinal nerve fiber layer thickness.

Eligibility criteria:
inclusion criteria: * subject diagnosed as unipolar depression * subject with depression to be treated with electroconvulsive therapy * subject with depression having a standardized mini mental test score of \>23 exclusion criteria: * any comorbid psychiatric condition (including alcohol / substance use) * having any major neurological (i.e.: cerebrovascular disease, multiple sclerosis, etc.) disease * having any major medical (i.e.: diabetes mellitus, myocardial infarction, etc.) disease * history of or having any ocular trauma, disease or surgery, any retinal disease, refraction defect * to be treated with electroconvulsive therapy in the last 6 months

Keywords: depression electroconvulsive therapy retinal nerve fiber layer optical coherence tomography
carbetocin vs. oxytocin for prevention of postpartum bleeding in patients with severe preeclampsia

Conditions: Severe Preeclampsia; Postpartum Hemorrhage

Summary: postpartum hemorrhage is an important cause of maternal morbidity and mortality. in patients with severe preeclampsia there is an increased risk of postpartum hemorrhage but the hemodynamic changes associated with this pathology make the management of any kind of bleeding particularly troublesome. there are many pharmacological options, being oxytocin the first line of treatment. however there is no evidence about the safety and efficacy of carbetocin, an oxytocin agonist. the investigators aimed to compare oxytocin with carbetocin for the routine prevention of postpartum hemorrhage in patients with severe preeclampsia.


Eligibility criteria:
inclusion criteria: * pregnant women between 28 weeks and term * severe pre-eclampsia exclusion criteria: * twin pregnancy * coagulation disorders * hellp syndrome * eclampsia

Keywords: pre-eclampsia postpartum hemorrhage carbetocin oxytocin
effects of biofeedback exercises on severity of dysphagia in parkinson's clients

Conditions: Oropharyngeal Dysphagia

Summary: a randomized control trial will be conducted to test if there will be a significant effect or not, of biofeedback exercises vs traditional exercises for clients with oropharyngeal dysphagia in parkinson's disease. for this purpose, 32 participants will be taken for the study. half will be given traditional exercises where as the other half will be given exercises using the biofeedback; tongueomter.

an rct will be conducted on 32 parkinson's patients having oropharyngeal dysphagia. fois and biofeedback will be used as a baseline instrument to determine the tongue strength and severity of dysphagia at the initial level of the study. the experimental group will perform tongue isometric pressure exercises using biofeedback for twelve sessions, four sessions per week. the control group will perform only traditional tongue-strengthening exercises for twelve sessions, four sessions per week. both groups will receive therapy for 30 minutes. both groups will undergo twelve sessions of exercises, starting after a baseline evaluation. each patient will receive therapy for 30 minutes and have four sessions of therapy weekly. two exercise protocols will be used. protocol a will involve biofeedback strengthening exercises using the tongueometer. protocol b will involve traditional tongue exercises to improve coordination and strength in tongue movement. the experimental group will be instructed to perform protocol a while the control group will be instructed to perform protocol b. each group after randomization will undergo twelve sessions of exercises and baseline assessment will be taken at initial, middle, and final levels.

Eligibility criteria:
inclusion criteria: * diagnosed cases of parkinson disease * diagnosed patients of oropharyngeal dysphagia with both genders exclusion criteria: * cognitive impairment

Keywords: parkinson
genetics of covid-19 susceptibility and manifestations

Conditions: COVID-19; Coronavirus 2019

Summary: background: coronavirus 2019 (covid-19, or sars-cov-2) is a serious public health problem, and genetics may play a role in how serious the illness becomes in certain people. genes are the instructions that our body uses to grow and develop. variations in our genes can cause medical conditions and may be the reason why some people get sicker than others. objective: this study aims to learn more about the genetic contributions to the severity of covid-19. we hope to use this information to develop therapies that reduce the severity of covid-19 symptoms in some people. eligibility: anyone located in the united states who has tested positive for sars-cov-2 infection may be eligible to join (including nih staff). design: participants will complete a questionnaire about their health history and covid-19 symptoms. participants will give a blood or saliva sample. it will be about 2 tablespoons of blood, or we will send a saliva collection kit. researchers will use this blood or saliva sample to study the participant s dna. the data about participants genes will be stored in a large database. the database will be shared with other qualified researchers who are trying to learn about covid-19. participants names and other personal details will not be shared. instead, the data will be labeled with a code. participants may be contacted by study team members for up to a year after they join the study.

the current sars-cov-2 pandemic presents a serious challenge to public health. individuals infected with sars-cov-2 experience extremes in symptomatology ranging from a complete lack of symptoms to rapidly worsening end-stage pulmonary disease. the explanatory mechanism underlying susceptibility to severe disease remains unknown. we hypothesize that underlying genetic factors are at least partially explanatory. we aim to employ a phenotypic extremes approach to rapidly ascertain severely and mildly affected covid-19 patients for genomic interrogation to identify germline and somatic variants that may play a role in host susceptibility to disease to correlate those phenotypic extremes with genetic variants. we will employ both a rare and common variant approach, using both genome sequencing and snp chip analysis and b and t cell repertoire interrogation.

Eligibility criteria:
* inclusion criteria * cohort 1 (existing nih clinical center patient/participants invited to participate by their nih study team) * cohort 2 (individuals recruited through nih occupational medicine services (oms) patients referred by nih investigators or other providers; individuals who self-refer) * located in the united states * positive test for sars-cov-2 virus infection * age greater than or equal to 3 years old * only for participants providing a blood sample exclusion criteria: * individuals for whom we cannot consent for participation in a language offered by our existing interpretation service. * weight less than 10 kg\*

Keywords: sars-cov-2 whole exome sequencing coronavirus 2019 natural history
stool antigen in diagnosis of helicobacter pylori

Conditions: Helicobacter Pylori Infection

Summary: helicobacter pylori is among the most common bacterial infections in humans. helicobacter pylori is a gram-negative, s -shaped rod .the most likely mode of transmission is fecal-oral or oral-oral. helicobacter pylori infection is acquired in early life and continues to have a high prevalence, especially in developing countries. growing antibiotic-resistant strains necessitate adapted treatments. the majority of children with helicobacter pylori infection remain asymptomatic, although a percentage of the infected children do develop helicobacter. pylori-associated diseases. helicobacter pylori is closely associated with the development of gastritis, gastric or duodenal ulcers. helicobacter pylori infection can manifest with abdominal pain or vomiting and, less often, refractory iron deficiency anemia or growth retardation. helicobacter pylori can be associated, though rarely, with chronic autoimmune thrombocytopenia. anemia, idiopathic thrombocytopenic purpura, short stature, and sudden infant death syndrome (sids) have also been reported as possible extra-gastric manifestations of helicobacter pylori infection . the diagnosis of helicobacter pylori infection is made histologically by demonstrating the organism in the biopsy specimens. 13 c-urea breath tests and stool antigen tests are reliable noninvasive methods of detecting helicobacter pylori infection in patients who do not require endoscopic evaluation. however, some guidelines recommend that non-invasive assessment methods are reserved to determine whether helicobacter pylori has been eradicated not for diagnosis .however helicobacter pylori-associated gastritis may, however, be an incidental histopathologic finding during upper endoscopy performed for unrelated indications such as the diagnosis of inflammatory bowel disease, or celiac disease.


Eligibility criteria:
inclusion criteria: - 1. children and adolescents between 4 and 18 years old having chronic or reccurent unexplained dyspeptic symptoms (epigastric pain, post prandial fullness, early satiety, bleching, heart burn, bloating, flatulence, regurgitation, nausea, vomiting and/ or halitosis)(miwa et al.,2012) and/ or non variceal hematemesis 2. the dyspeptic symptoms should be present at least 2months duration , which doesn't need to be consecutive, during the previous 6 months.(rasquin et al., 2006) exclusion criteria: - 1. patients who received anti sectertory drugs and/ or antibiotics in the previous 4 weeks before endoscopy. 2. patients less than 4years and more than 18 years old.
pmcf to assess real-life usage effectiveness, safety and patient satisfaction of a range of hypertonic seawater-based decongestant nasal sprays

Conditions: Allergic Rhinitis; URTI

Summary: the brief of this observational study is to evaluate usage, efficacy, safety and patient satisfaction of a range of hypertonic seawater-based decongestant nasal sprays in general population. the main questions it aims to answer are: * usage, * efficacy, * safety, * satisfaction, in real-life usage with children, adults and pregnant or breastfeeding women. participants will use the nasal spray as usual habits and complete daily questionnaires.


Eligibility criteria:
inclusion criteria: * subject coming to pharmacy for spontaneous purchase of one of the medical device under investigation. * subject willing to buy one of the medical device under investigation following advice from pharmacist, general practitioner or any other health care professionals. * adult and children from 3 years old in compliance with the information for use. * subject presenting moderate nasal congestion or more. * subject agreeing to follow the study requirements during the whole study period. * subject having daily access to internet in order to answer online questionnaire. * subject able to understand verbal and written local language and in capacity to fill-in questionnaire himself. * subject able to give inform consent. exclusion criteria: * subject with contraindications according to the information for use. * hypersensitivity or know allergy to any component of the product. * subject taking part in another clinical study or being in the exclusion period of another clinical study. * subject already included once in this study or having a family member already included in this study for the same indication. * vulnerable subject (except children, pregnant and breastfeeding women).

Keywords: medical device hypertonic seawater-based nasal spray