Kornimate/medical-research-clean huggingface dataset:
indocanine green as tracer for lymph nodes dissection in station 253

Conditions: Rectal Carcinoma; Sigmoid Colon Carcinoma

Summary: this is a prospective randomized controlled study. investigators will randomly assign patients to the indocanine green (icg) group and control (cl)group to compare the differences of lymph nodes dissection in station 253 between the two groups.

icg is a registered and fda-approved non-specific fluorescent probe for optical imaging in clinical settings. the properties of icg ,which is a water-soluble amphiphilic molecule with a molecular weight of 775 dalton and a hydrodynamic diameter of 1.2nm ,render it an excellent lymphatic contrast agents if injected into the lymphatic system. icg near-infrared(nir) fluorescent imaging has achieved satisfactory results in the localization of sentinel lymph nodes in patients with breast cancer,non-small cell lung cancer,and gastric cancer. liang et al have suggested that 253 lymph nodes dissection in rectal cancer is technically demanding ,and that learning curve for laparoscopic 253 lymph nodes dissection requires minimally 20 procedures. currently,it was still controversial about 253 lymph nodes dissection in rectal cancer surgery. however, lymph node involvement is a major prognostic factor for survival after rectal cancer surgery. therefore, it is necessary to harvest more station 253 nodes for the better long-term survival and the more precise staging. in this study, investigators will randomly assign patients to the indocanine green (icg) group and control (cl)group. number of harvested station 253 lymph nodes, number of positive station 253 lymph nodes, will be evaluated and compared. investigators will also evaluate patients, operative time, blood loss, post-operative hospital stay and complications.

Eligibility criteria:
inclusion criteria: (1)18-80 years of age (2)american society of anesthesiologists (asa) class 1-3 (3)single rectal or sigmoid colon carcinoma confirmed pathologically by endoscopic biopsy (4)planned laparoscopic radical resection (5)written informed consent exclusion criteria: 1. previous abdominal tumor surgery 2. women who are pregnant or breast feeding 3. emergency patients with obstruction or perforation 4. t4b cancer evaluated by ct or mri or endoscopic ultrasonography 5. pelvic or distant metastasis 6. t1 cancer planned local excision 7. allergic constitution patients

Keywords: icg 253 lymph nodes rectal carcinoma sigmoid colon carcinoma
effects of cpap on ventricular function modifications

Conditions: Heart Failure, Congestive

Summary: to assess modifications of ventricular function induced by cpap (continuous positive airway pressure).

there are still few studies on the effects of positive intra-thoracic pressure on ventricular function and spontaneous baroreflex sensitivity changes. aim of the study is to evaluate, in patients with chronic heart failure with an ejection fraction \< 40%, the modifications of ventricular function induced by cpap (continuos positive airway pressure) application. all the measurament will be made in basal condition (without cpap) and with cpap administration at 10 cmh2o via an oro-nasal mask. echocardiograpich evaluation: morphologic and hemodynamic evaluation is obtained with an echocardiographic exmination. left ventricular measurement will be assessed in m-mode, under two dimensional guide) according to american society of echocardiography guidelines. left ventricular ejection fraction will be assessed with simpson method. right ventricle morphology will be evaluated categorizing dimensions in a) normal, b) mild enlargement, c) severely increased and d) reduced. right ventricle area will also be quantified in tele-diastole and in meso-sistole in apical 4 chamber and parasternal short-axis. baroreflex control of heart rate was assessed by "sequence method" analysis of continuous blood pressure recordings obtained in basal condition and during cpap. data obtained by non invasive assessment of arterial pressure will be analized and values of arterial systolic, diastolic pressure and pulsatory period for each cardiac cicle will be registered. assessment via "sequence method" is founded on identification, every 10 minutes, on sequences characterized by a progressive increase both in pressure both in rr interval or, conversely, by a progressive reduction of pressure and rr interval evaluated on 4 or more cardiac cicles.

Eligibility criteria:
inclusion criteria: * diagnosis of heart failure * chronic heart failure * ejection fraction \< 40% exclusion criteria: * age \< 18 years * permanent atrial fibrillation * infiltrative cardiomyopathy * mild/moderate chronic obstructive lung disease * chronic heart failure * diabetes mellitus * chronic kidney failure

Keywords: heart failure, congestive continuous positive airway pressure baroreflex echocardiography
the relationship of neuropathic pain with incontinence, disability and life quality in multiple sclerosis patients

Conditions: Multiple Sclerosis; Disabilities Multiple; Quality of Life; Incontinence, Urinary; Incontinence Bowel; Neuropathic Pain

Summary: the aim of this study to evaluate the relationship of neuropathic pain with urinary and bowel incontinence, functional disability and quality of life in patients with multiple sclerosis.

the patient's date of birth, gender, education level, body mass index, occupation, marital status, socioeconomic status, who they live with, the onset of their complaints about the disease, the time of diagnosis of multiple sclerosis (ms), the type of ms, the presence of any pain and the type of pain will be recorded. then, while the patients will be evaluated by researcher dr alper mengi in terms of neuropathic pain, incotinance, disability and independence in activities of daily living. the forms to be used in terms of health perceptions and quality of life, anxiety and depression, and sleep quality will be filled by the patients.

Eligibility criteria:
inclusion criteria: * being diagnosed with ms according to the 2017 revised mcdonald criteria * being between the ages of 18-65 * being in remission (no progression in attacks or disability in the last 3 months). exclusion criteria: * having another known neurological disease * having been diagnosed with a psychiatric disease such as depression, anxiety, bipolar disorder * having a history of infectious, chronic inflammatory disease, malignancy * having cardiac pathology such as heart failure, coronary artery disease * diabetes, chronic kidney failure, chronic liver failure * being addicted to alcohol and substance * using permanent urinary catheter
use of laser interstitial thermal therapy in the focal treatment of localized prostate cancer

Conditions: Prostate Cancer

Summary: this is a pilot, feasibility/exploratory study to evaluate the safety of laser interstitial thermal therapy (litt) using visualase in the focal treatment of localized prostate cancer as well as to gather data for the design of future studies.


Eligibility criteria:
inclusion criteria: * subjects with initial presentation of organ confined prostate cancer (clinical stage ≤ t2b) * negative metastatic workup with bone scan and ct abdomen/pelvis, within 6 months of study treatment, if indicated by psa \>10 * age 40 years to 85 years of age * multi-parametric mri at ucla within 6 months of study treatment, demonstrating a * region of interest (roi) of mri suspicion level 3 or higher * roi located proximal to the external sphincter by a margin of at least 2 cm * transrectal ultrasound-guided biopsy with ≥ 10 systematic biopsy cores and ≥ 2 mri-ultrasound fusion targeted biopsy cores from above mri-derived roi * histologically-confirmed adenocarcinoma from targeted biopsy cores (≥ 2 cores) * overall gleason score not to exceed 3+4 * subjects desire focal therapy and declined conventional treatment (active surveillance, radical prostatectomy, radiation therapy, cryosurgery and hormone therapy) * signed informed consent for the litt treatment through the 12 month follow up visit exclusion criteria: * any significant cancer outside of mri target (roi) area, defined as gleason score \> 3+4 * \< 10 years life expectancy * american society of anesthesiologists (asa) criteria of iv or higher * unfit for conscious sedation anesthesia * active bleeding disorder as determined by abnormal prothrombin time, partial thromboplastin time, inr or platelet count (as determined by institutional lab parameters) at the time of screening * use of coumadin or any other anticoagulant, unless anticoagulation can be temporarily reversed or stopped for a window of at least 7 days peri-procedure * active urinary tract infection * prostate abscess, chronic or acute prostatitis, or neurogenic bladder * any prior treatment for prostate cancer * radical prostatectomy * radiation therapy (external beam or brachytherapy) * cryotherapy * high intensity focused ultrasound treatment * photodynamic therapy * androgen deprivation therapy * prior prostate, bladder neck, or urethral stricture surgery * any prostate debulking procedure, including: transurethral resection of prostate, photovaporization, or electrovaporization * transurethral incision of bladder neck * urethral stricture dilation or reconstruction * any current 5-alpha reductase inhibitors (history of use ≥ 6 months prior to mri is acceptable) * prior significant rectal surgery (hemorrhoidectomy is acceptable) * rectal fissure, fibrosis, stenosis, or other anatomic abnormality precluding insertion of transrectal device * history of inflammatory bowel disease * urinary tract or rectal fistula * any contraindication to mri (contrast allergy severe claustrophobia, mri-incompatible prosthesis)

Keywords: focal therapy prostate cancer treatment laser treatment
diffusion weighted mri for lymphnodes in the axilla

Conditions: Breast Cancer

Summary: this study is going to compare diffusionweigthed mri scanning to the result of surgey in patients with metastasis from brestcancer in the axilla


Eligibility criteria:
inclusion criteria: newly diagnosed breast cancer patients, where ultrasound and cytologi has proved one or more malignant lymphnodes in the axilla. exclusion criteria: pacemaker metal in the body claustrphobia psychiatry patients pregnancy age below 18 years

Keywords: mri diffusion mamma cancer
telerehabilitation in hypertension

Conditions: Hypertension; Pre-hypertension; Healthy

Summary: the purpose of this rct which will be performed in 60 healthy adults is i. to assess the training effects of 8 weeks of isometric handgrip exercise on bp; and to test whether it yields at least similar effects on bp compared to current exercise recommendations. ii. to assess whether isometric handgrip training yields larger bp reductions beyond the supervised training period at 6 months of follow-up. iii. to determine whether changes in bp following acute exercise and chronic training can be explained by changes in important physiological mechanisms known to mediate or to be associated with bp?


Eligibility criteria:
inclusion criteria: * not physically active (\< 3 hours of moderate to high levels of pa/week) low cardiovascular risk according to current guidelines (mancia et al j hypertens 2013) will be recruited through advertisements. the latter is defined as: * \>115 mmhg \< systolic bp \< 139 mmhg and/or 75 mmhg\< diastolic bp\<90mmhg in the presence of 0 to a maximum of three other cardiovascular risk factors, excluding diabetes or * 139 mmhg \< systolic bp \< 160 mmhg and/or 90 mmhg\<dbp\< 100 mmhg in the absence of other cardiovascular risk factors exclusion criteria: * current smoker * pregnancy * presence of other cardiovascular disease, pulmonary disease or metabolic disease * inability to perform a standard exercise program due to mental/physical disability. * use of antihypertensive drugs
eureka italy - evaluation of real-life use of klox biophotonic system in chronic wounds management

Conditions: Venous Leg Ulcer; Diabetic Foot Ulcer; Pressure Ulcer

Summary: multi-center, prospective, interventional, uncontrolled open-label study evaluating the real-life use of klox lumiheal biophotonic system in chronic wounds management (venous leg ulcers, diabetic foot ulcers, pressure ulcers).


Eligibility criteria:
inclusion criteria: * signed and dated written informed consent form; * adult patient (at least 18 years old) having received a diagnosis of venous leg ulcer, diabetic foot ulcer or pressure ulcer by the investigator; * the treating physician (investigator) believes the klox lumiheal biophotonic system would be an appropriate option; * both male and female patients must be willing to adhere to a medically-accepted birth control method during the course of the study; * willingness to comply with study requirements (visits, treatments, etc.). exclusion criteria: * female pregnant patient (by medical history or as ascertained by a pregnancy test); * breast-feeding female patient; * patients taking drugs/products (e.g., methotrexate, chemotherapy agents) or with conditions (e.g., porphyria) known to induce severe photosensitivity reactions; * patients with known skin hypersensitivity.
efficacy and mechanisms of psychosocial treatments for panic disorder

Conditions: Panic Disorder

Summary: the aim of the present study is to a) determine the comparative efficacy of the brief capnometry-assisted respiratory therapy (cart) and standard cognitive behavioural therapy (cbt), and b) to determine moderators and mediators. with the data collected from the study, the investigators will test the following hypotheses: (a) cart will be as effective in treating pd/a as cbt, albeit in shorter time, b) patients with greater respiratory dysregulations, especially hyperventilation, at pretreatment will benefit more from cart, whereas patients with greater cognitive dysregulation will benefit more from cbt. cart, but not cbt, will result in reversal of hyperventilation.


Eligibility criteria:
inclusion criteria: 1. a current dsm-iv (diagnostic and statistical manual iv) diagnosis of panic disorder with or without agoraphobia that is designated by the patient as the most important source of current distress 2. patients must be willing to engage in exposure to fearful situations and sensations. exclusion criteria: diagnostic exclusion criteria: 1) a history of bipolar disorder, psychosis or delusional disorders (as evaluated by the scid-iv-l (structured clinical interview for the dsm iv) screening questions), substance abuse or dependence or alcohol abuse or dependence (other than nicotine in the last 3 months) medical exclusion factors: 1. patients with severe unstable medical illness, clinically significant laboratory findings, or serious medical illness for which hospitalization may be likely within the next three months 2. patients with a history of seizures, angina, myocardial infarction, congestive heart failure, clinically significant arrhythmias, transient ischemic attacks, cerebrovascular accidents, diabetes mellitus, significant asthma, emphysema, or chronic obstructive pulmonary disease
study of opioid use after lumbar and cervical spine surgery

Conditions: Low Back Pain; Opiate Addiction; Neck Pain

Summary: the purpose of this project is to assess the impact of an educational video on the use of prescription opioid medication during a 6-month period following spine surgery. subjects will be recruited from the pool of patients coming in for the pre-operative appointment prior to spine surgery. patients that consent and enroll will be randomized to receive either a brief educational video at this appointment or usual care. patients will be followed after surgery weekly for the first month, and then again at 6 months to determine their prescription opioid medication utilization patterns. prescription data will also be pulled from electronic medical records.

after consenting, meeting inclusion criteria, and enrollment, all participants will complete several standard self-report questionnaires related to medical history, social demographic, and psychosocial variables that are related to low back pain, and often used in clinics that manage patients with low back pain. they will then be randomized to either receive the education, or only usual care (which is the typical information the surgeon provides the patient verbally during the pre-operative appointment). all patients will receive the usual care education from their surgeon. education group: the educational video is a white board style patient-centric video. the content of the education focus on providing a historical perspective for opioid prescription from the time when the risk of dependence was highly underestimated. the video discusses the current evidence for the effect of opioid medications in non-cancer on-acute pain. it also discusses some of the dangers of long-term opioid usage. all subjects: all subjects will receive the usual care education that is typically given by their surgeon. that will be left up to the discretion of each surgeon. all patients will proceed with the surgical procedure as planned. each week during the 1-month period after the surgery, patients will be contacted, and then again at 6 months to ask history of prescription opioid utilization.

Eligibility criteria:
inclusion criteria: 1. currently scheduled for a pre-operative appointment with an orthopaedic spine surgeon or neurosurgeon specifically for a lumbar surgery. 2. surgery is taking place for a condition that has been ongoing for 6 months or longer (chronic) 3. between the age of 18 - 65 years 4. read and speak english well enough to understand the education, provide informed consent and follow study instructions exclusion criteria: a. known aversion or allergy that would prevent the patient from taking any opioid based pain medication

Keywords: patient education low back pain post-surgical pain chronic opioid use neck pain
abdominal adipose tissue distribution in type 2 diabetic patients treated during 6 months with pioglitazone or insulin

Conditions: Type 2 Diabetes

Summary: in type 2 diabetic patients with poor glycemic control despite maximum "classic" oral treatment, bed time insulin therapy may lead to a parallel increase in abdominal visceral and subcutaneous fat, whereas pioglitazone treatment should lead to a stability (or even a decrease ) in visceral and an increase in subcutaneous abdominal fat. as visceral fat mass is correlated with insulin-resistance and cardio-vascular risk, the evolution of visceral abdominal fat in type 2 diabetic patients is of great importance. main objective: to compare visceral and subcutaneous abdominal fat compartment after a six-month bed time insulin or pioglitazone treatment in type 2 diabetic patients with poor glycemic control despite a maximal oral treatment with metformin and sulfonylureas. the study hypothesis is that quantity of visceral and subcutaneous abdominal adipose tissue should differently evolute comparing a 6 month treatment with pioglitazone® (30 or 45mg/j) or nph " bed-time " insulin (0.2u/kg/

in type 2 diabetic patients with poor glycemic control despite maximum "classic" oral treatment, bed time insulin therapy may lead to a parallel increase in abdominal visceral and subcutaneous fat, whereas pioglitazone treatment should lead to a stability (or even a decrease ) in visceral and an increase in subcutaneous abdominal fat. as visceral fat mass is correlated with insulin-resistance and cardio-vascular risk, the evolution of visceral abdominal fat in type 2 diabetic patients is of great importance. the study hypothesis is that quantity of visceral and subcutaneous abdominal adipose tissue should differently evolute comparing a 6 month treatment with pioglitazone® (30 or 45mg/j) or nph " bed-time " insulin (0.2u/kg/

Eligibility criteria:
inclusion criteria: * type 2 diabetes * bmi= 26kg/m2 * maximal treatment with metformin and sulfonylurea * hba1c between 7.5 and 9.5% exclusion criteria: * anterior treatment with glitazones * anterior treatment with insulin * known heart failure * hepatopathy * renal filtration less than 60ml/min, hb\<10g/dl * corticoids treatment

Keywords: type 2 diabetes
effect of met with and without mcte in mechanical neck pain

Conditions: Mechanical Neck Pain

Summary: work had to be done previously on mets and mcte techniques, but no study has compared both techniques together to make it more comprehensible. the rationale of this will be to find out the combined effect of motor control therapeutic exercises and muscle energy technique for the treatment of pain, range of motion and disability associated with mechanical neck pain. this study will be effective for the clinicians to treat patients of mechanical neck pain.

therapeutic exercises and manual therapy were shown to be useful in managing pain and lowering disability in patients with non-specific chronic neck pain (ncnp). however, little studies investigated the benefits of muscle energy technique and motor control therapeutics exercise on mechanical neck pain (mnp). the current research fulfill this gap by comparing the short and long term benefits of muscle energy technique with and without motor control therapeutic exercises (mcte) with the grail of determining best approach for lowering pain and disability in mechanical neck pain patients.

Eligibility criteria:
inclusion criteria: * • subjects were between 20 and 50 years old. * pain in cervical or neck region with no radiating pain in one or both upper limbs. * pain minimum of 3 months. * neck disability index (ndi) score of should be at least 10%. * forward head posture. exclusion criteria: * • neck pain associated with vertigo. * irradiated neck pain. * vertebral fracture. * osteoporosis. * previous neck injury. * red flags (night pain, severe muscle loss, loss of involuntary control. * subjects with difficulty in communication or understanding.

Keywords: neck pain range of motion muscle energy technique motor control therapeutic exercise
the effect of caudal block on optic nerve sheath diameter in pediatric patients

Conditions: Postoperative Pain; Intracranial Hypertension

Summary: caudal epidural block has been a widely used regional anesthesia method, especially in pediatric surgery, to provide intraoperative and postoperative analgesia. studies on non-invasive methods used for intracranial pressure measurement have shown that optic nerve sheath diameter is related to intracranial pressure. optic nerve sheath diameter measurement has high diagnostic accuracy for detecting increased intracranial pressure in children. the aim of the study is to investigate the effect of the caudal block on optic nerve sheath diameter in pediatric patients.


Eligibility criteria:
inclusion criteria: * circumcision, * inguinal hernia, * undescended testis, * hydrocele operation exclusion criteria: * neurological or spinal anomaly, * coagulopathy * allergy to local anesthetics, * local infection in the area to be intervention, * with increased intracranial pressure * children with any ophthalmic pathology
hiv and inflammatory or autoimmune disease: rare patients, many questions (maivih)

Conditions: Hiv

Summary: follow-up registry of patients living with hiv who also have various inflammatory and autoimmune pathologies that may require immunosuppressive treatment.


Eligibility criteria:
inclusion criteria: * patient living with hiv * carrier of one or more of the following diseases: sarcoidosis multiple sclerosis myasthenia gravis crohn's disease hemorrhagic rectocolitis autoimmune hepatitis arthropathic psoriasis still's disease, other rheumatoid arthritides, juvenile polyarthritides, rheumatoid arthritis vasculitides: periarteritis nodosa and related conditions, other necrotizing vasculopathies (periarteritis nodosa, juvenile periarteritis, churg-strauss disease, polyangiitis, kawasaki disease, horton's disease, wegener's disease, thrombotic microangiopathy, takayashu syndrome, good-pasture's syndrome, thrombocytopenic purpura) lupus polymyositis or dermatopolymyositis connectivitis (behcet's disease, gougerot-sjöogren syndrome) inflammatory spondyloarthropathies (aps, spondyloarthritis, other spondyloarthropathies) exclusion criteria: * opposition of the person * minor patients * patients under judicial protection