Kornimate/medical-research-clean huggingface dataset:
breathing exercise for rib fracture

Conditions: Rib Fractures; Spirometry

Summary: respiratory physiotherapy is routinely performed after thoracic surgery operations to increase lung expansion and prevent pulmonary complications such as atelectasis and pneumonia. it is a controversial issue whether respiratory physiotherapy reduces pulmonary complications in rib fractures. in our study, patients with rib fractures will be divided into two groups. in the control group, standard treatment consisting of routine analgesic treatments will be applied. in the other group, respiratory physiotherapy will be applied with triflu for 8 hours a day. at the end of the study, pulmonary complications in both groups will be compared.

patients between the ages of 18 and 100 who will apply to our hospital due to rib fractures between april 2024 and april 2025 will be evaluated. patients who meet the inclusion criteria will be included in the study. patients will be divided into two groups using randomization blocks. patients in the control group will receive conservative treatment consisting of paracetamol and dexketoprofen. in the other group of patients, in addition to conservative treatment, triflow breathing exercise will be applied for 8 hours a day. respiratory function test pain scores and pulmonary complications of patients in the two groups will be compared statistically.

Eligibility criteria:
inclusion criteria: * isolated thoracic injury within 24 hours * age between 18-100 exclusion criteria: * pneumothorax and hemothorax requiring intervention at admission * injury severity index \>16 * copd, atshma * extrathoracic trauma
genetic study in patients with stage ii or stage iii colon cancer

Conditions: Colorectal Cancer

Summary: rationale: genetic studies may help in understanding the genetic processes that cause some types of cancer. purpose: genetic trial to study certain genes of patients who have stage ii or stage iii colon cancer.

objectives: * determine the adverse prognostic significance of 8p allelic imbalance (ai) in patients with colon cancer. * determine if patient prognosis is dependent on the region of 8p ai. * perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p. * perform multicolor fish to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p ai. outline: matched normal and tumor dna is analyzed for 8p allelic imbalance with at least 8 markers: d8s262 and d8s1825 localized to 8p23, d8s254 and d8s261 at 8p22, d8s560 and d8s136 at 8p21, and d8s1820 and d8s283 at 8p12. normal/tumor tissue pairs are used for fine mapping studies.

Eligibility criteria:
disease characteristics: * diagnosis of resectable stage ii or iii adenocarcinoma of the colon * participated in ncctg-914653 * dna extracted from both normal and tumor tissue patient characteristics: age * under 70

Keywords: stage ii colon cancer stage iii colon cancer adenocarcinoma of the colon
changes in and determinants of movement performance, functional status, and health-related quality of life after stroke rehabilitation

Conditions: Stroke; Rehabilitation

Summary: a total of 144 stroke patients 6 -24 months post onset who are between 45 and 75 years old will be recruited. a randomized-blocks pretest and posttest control group design will be applied. four groups will be involved in this project and the subjects will be stratified on two variables: impairment level of the hand and side of lesion. randomization will be done in blocks of six and each block randomization scheme is within each stratum. treatment regimens will be designed to ensure that patients in 4 groups receive equivalent intensity of treatment (5 days/week for 1.5 hours/day for 4 consecutive weeks) directly supervised by senior occupational therapists. brain and movement reorganization will be evaluated with fmri and kinematic instrument, respectively before and after the 4-week intervention period. clinical measures on motor impairment, daily function and quality of life will be assessed before, immediately and six months after intervention. two examiners blind to group allocation will collaborate to provide both fmri and kinematic evaluations and one of them will administer clinical measures. before being allowed to work with subjects, the examiner competence will be assessed by principle investigator and co-principle investigators. multivariate analyses of covariance will be used to examine change in brain activation, kinematic variables and clinical measures as a function of intervention while controlling for pretest data, age and onset post stroke. multiple regression models will be established to examine the possible predictor(s) for functional outcome of each rehabilitation approach. canonical correlation analyses will be conducted to quantify the relationship between brain/motor reorganization and clinical measures.


Eligibility criteria:
inclusion criteria: 1. able to reach brunnstrom stage iii or above for the proximal part of the affected upper limb(brunnstrom, 1970); 2. considerable nonuse of the affected upper limb (amount-of-use \[aou\] score \< 2.5 on the mal) (taub, miller, novack, et al. ,1993); 3. no serious cognitive deficits (score \> 24 on the mini mental-state exam) (folstein, folstein, \& mchugh, 1975); 4. no balance problems compromising safety when wearing the constraint device; and, 5. no excessive spasticity (modified ashworth scale ≤ 2 at any joint of the upper limb) (bohannon, \& smith, 1987).
ramipril in rheumatoid arthritis

Conditions: Arthritis, Rheumatoid

Summary: the present study is designed to evaluate the hypothesis that the angiotensin-converting enzyme (ace) inhibitor ramipril improves vascular function and reduces markers of low-grade chronic inflammation and oxidative stress in patients with rheumatoid arthritis.

the effect of an 8-week treatment with either ramipril or placebo is studied using a randomized, double-blind, and crossover protocol. after given written informed consent, baseline characteristics including physical examination, ecg, blood sample and a noninvasive assessment of endothelial function are obtained. the patients are randomly assigned to receive either ramipril 10mg (up-titration-scheme: starting with 2.5mg in week1, then 5mg in week2 followed by 2-5mg for the final 6 weeks) followed by placebo or vice versa.the individual disease-modifying antirheumatic drug therapy is continued throughout the study. the examinations are repeated after 8 weeks treatment of the first and 8 weeks after the second study drug. at week 1 and 2 in each treatment period a safety visit is scheduled.

Eligibility criteria:
inclusion criteria: * patients with rheumatoid arthritis (4 out of 7 ara criteria must be fulfilled to establish diagnosis) on stable background therapy for the last three months * endothelial dysfunction (fmd \< 4%, fmd:flow-mediated-dilatation) * non-smokers exclusion criteria: * previous myocardial infarction, coronary intervention or coronary surgery * previous treatment with statins in the last 6 months * previous treatment with ace-inhibitors in the last 6 months * uncontrolled hypertension sap/dap \> 160/90 mmhg (sap:systolic arterial pressure, dap:diastolic arterial pressure) * dyslipidemia (ldl-cholesterol \> 4.9 mmol) * normal crp \< 3 mg/l * overweight bmi \> 35kg/m2 * anaemia (hemoglobin \< 10g/dl) * kidney disease (creatinine \> 150 umol/l) * insulin-dependent diabetes mellitus * congestive heart failure (\> nyha i) * av-block\>i * pregnancy * angio-edema * malignancy or chronic infection * drug abuse
voiding and erectile function after retroperitoneal lymph node dissection for testictular cancer

Conditions: Testicular Cancer

Summary: this study aims to evaluate how retroperitoneal lymph node dissection (rplnd), a surgical treatment for testicular cancer, may affect urinary and sexual functions in men. rplnd involves the removal of lymph nodes from the abdominal area and is sometimes necessary in patients who are not eligible for chemotherapy or who have residual disease after chemotherapy. while this surgery is known to carry a risk of affecting ejaculation, its potential impact on other areas such as urination or erection is not well understood. the study will prospectively follow adult men undergoing rplnd. it will assess changes in lower urinary tract symptoms, urine flow, ejaculation, erection, and overall quality of life before surgery and during follow-up visits up to 6 months after the operation. patients will complete standardized questionnaires and undergo simple, non-invasive tests such as urine flow measurement. by identifying how rplnd may influence urinary and sexual health, this study seeks to improve understanding of the full range of effects of this treatment. the findings may help clinicians better inform patients before surgery and support improved post-operative care.

this is a prospective observational study designed to evaluate the impact of retroperitoneal lymph node dissection (rplnd) on lower urinary tract and sexual function in patients treated for testicular cancer. the study incorporates validated patient-reported outcome measures (proms) alongside objective functional assessments to characterize post-rplnd urinary and sexual sequelae over time. patients will complete standardized questionnaires preoperatively and at scheduled postoperative intervals, including the international prostate symptom score (ipss), international consultation on incontinence questionnaire - male lower urinary tract symptoms (iciq-mluts), international index of erectile function (iief-5), male sexual health questionnaire - ejaculatory dysfunction (mshq-ejd), and eq-5d-5l for health-related quality of life. objective evaluation will include uroflowmetry and ultrasound-based measurement of post-void residual volume.

Eligibility criteria:
inclusion criteria: * adult male with testicular cancer undergoing retroperitoneal lymph node dissection (rplnd) exclusion criteria: * history of rplnd * lack of consent

Keywords: testicular cancer retroperitoneal lymph node dissection
influence of data collection mode on self-report validity of asthma therapy adherence

Conditions: Lung Diseases; Asthma

Summary: this study will examine how the assessment mode influences the validity of self-reported adherence to asthma therapy. self-reported adherence to asthma therapy data will be collected using one of three randomized assessment modes (interview, computer, or telephone).

background: self-reports are a primary source of behavioral data. studies have highlighted the variable validity and reliability of self-report measures of health behaviors such as adherence to therapy. research on self-reports of sensitive information, such as sexual behavior and drug use, suggests that the mode of data collection may enhance validity of self-reports. however, no studies have determined how the mode of data collection influences self-reports when an objective measure of the behavior is available. design narrative: the primary aim of this study is to examine the influence of the mode of data collection on the validity of self-reports of inhaled anti-inflammatory medication adherence. the key secondary outcomes of the study will attempt to answer the following questions: 1) does the assessment mode influence self-reports of commonly used asthma outcome measures of disease-related symptoms, self-management behaviors, and quality of life?; 2) does the relationship between the assessment mode, the validity of self-reports of adherence, and other measures (i.e., asthma symptoms, self-management behaviors, and quality of life) change over time?; and 3) does the assessment mode interact with baseline personality characteristics and mood to influence the validity of self-reports of adherence and other outcome measures (i.e., asthma symptoms, self-management behaviors, and quality of life)?

Eligibility criteria:
inclusion criteria: * diagnosis of asthma * under a provider's care for asthma * prescribed daily inhaled corticosteroids (by metered dose inhaler \[mdi\]) at least 2 times a day * speaks english * otherwise in good general health exclusion criteria: n/a
health4cll2: a randomized waitlist control trial of behavioral interventions in patients with chronic lymphocytic leukemia

Conditions: Chronic Lymphocytic Leukemia

Summary: to learn if exercise and weight management can help to improve feelings of fatigue in cll survivors.

primary objective: --evaluate the impact of an organized, longitudinal, diet and exercise training program on fatigue as assessed by the functional assessment of cancer therapy (fact) score in patients with cll. secondary objectives: --assess changes in physical activity, dietary behavior, physical function using the promis physical function questionnaire and performance tests of physical function, body mass index (bmi) and global quality of life. additionally, we will assess changes in fecal microbiome composition, metabolic parameters including a comprehensive lipid panel, glucose, insulin, tnf alpha, il6, leptin, resistin, adiponectin, igf1 and igfbp1 and immunologic function as assessed by t cell and monocyte phenotypic and functional assays in patients with cll after participation in the behavioral intervention. exploratory objectives: -- identify differences in the metabolic, immunologic and fecal microbiome composition in patients with cll who have a high cll comorbidity index score (cll-ci) compared to patients with cll and a low cll-ci score. and, investigate the association of comorbidity score, disease features, cll-specific prognostic factors and clinical outcomes.

Eligibility criteria:
inclusion criteria: * adults age 18-85 years of age with a histologically confirmed diagnosis of cll and the ability to provide signed informed consent. * self-reported physical activity will be assessed prior to enrollment and patients with a physical activity level below the level prescribed in our study will be eligible for inclusion. exclusion criteria: * other active malignancy within 1 year of study enrollment (excluding non-melanoma skin cancer) * richter's transformation, another medical condition which would prevent safe participation in the behavioral intervention * major surgery within 1 month of enrollment * non-english speakers * cognitively impaired adults * pregnancy.
knowledge and habits of pregnant teens

Conditions: Teen Pregnancy

Summary: this study examines the link between health literacy, gestational weight gain, and infant birthweight in pregnant teenagers. a randomized trial of 50 participants will be conducted at the university of mississippi medical center. consent will be obtained from all participants. both control and intervention groups will complete a 20 questions health literacy assessment at baseline and after eight weeks, along with the asa24 dietary recall tool twice weekly. the intervention group will join a private social media group created solely for study purposes. this will be a private account, accessible only to participants who are added or invited by the study team.

this research study is to see if someone's ability to understand and use health information (health literacy) is linked to gaining a healthy amount of weight during pregnancy and having a baby with a healthy birth weight. the main question aims to answer if there is a positive correlation between increased health literacy, gestational weight gain, and adequate infant birth weight. we are conducting a prospective randomized trial involving 50 pregnant teenagers and their baby at a single institution. we will obtain study consent for 18 and 19 years old, and parental permission and assent for 13 -17 years old. control group will complete the 20 questions health literacy during the first visit and after 8 weeks. also, will complete the online called asa 24 a 24-hour food recall tool. the asa24 will be completed 2x /week for 8 weeks. intervention group will complete the 20 questions health literacy during the first visit and after 8 weeks. also, will complete the online called asa 24 a 24-hour food recall tool. the asa24 will be completed 2x /week for 8 weeks. in addition, participants assigned to the intervention group will be invited to participate in a private social media group. participants will create a new account specifically for the study, or the study team can create an account on their behalf if they prefer. this will enable the study team to track participation without affecting any personal accounts. education content will consist of published dietary recommendations during pregnancy, healthy craving hacks, healthy snacks, ways to get exercise in during the school day, etc. participants will also be encouraged to ask questions and post any eating struggles.

Eligibility criteria:
inclusion criteria: * maternal age 13 - 19 yrs at enrollment * \< 19.6 gestational weeks * ability to understand english * access to a smartphone or internet * willingness to follow study procedures * plan to deliver at ummc * singleton pregnancy exclusion criteria: * does not meet the inclusion criteria * history of diabetes * current record of substance abuse * mental impairment * eating disorder

Keywords: gestational weight gain infant birth weight health literacy
optical frequency domain imaging (ofdi) surveillance and image guided biopsy of the esophagus

Conditions: Barrett's Esophagus

Summary: the specific aim of this study is to determine the feasibility of marking target pathologic locations identified on optical frequency domain imaging (ofdi) datasets using superficial cautery marks of the esophagus that are visible by endoscopy for subsequent guidance of biopsy.

twenty four consenting patients undergoing esophagogastroduodenoscopy (egd) surveillance following a confirmed diagnosis of barrett's esophagus will be recruited at massachusetts general hospital (mgh) . along with optical frequency domain imaging (ofdi) imaging and cautery marking for targeted biopsy, the patients will undergo a standard of care clinical esophagogastroduodenoscopy (egd) procedure including endoscopic random biopsy. this study requires the use of a balloon catheter which is a commonly used technique and is accepted in clinical practice for dilation of esophageal and colonic strictures and for photodynamic therapy. once in position, the ofdi tissue marking laser will be activated by the physician. the physician will control the marking and make two marks of a duration of 2 seconds each. the 2 seconds time period will limit the tissue effects to only the superficial layers of the esophageal mucosa. it is expected that the total experimental time including insertion and inflation of the ofdi balloon catheter, ofdi imaging, tissue marking, and removal of the ofdi balloon will add approximately 15 minutes to the total length of the egd.

Eligibility criteria:
inclusion criteria: * patients undergoing an egd for barrett's esophagus surveillance with a prior confirmed barrett's segment at least 1 cm in length * patients must be over the age of 18 * patient must be able to give informed consent * women with child bearing potential must have a negative pregnancy test prior to procedure exclusion criteria: * patients on anti-platelet and anti-coagulation medications and nsaids at the time of procedure * patients with a history of hemostasis disorders * patients that are pregnant * patients with esophageal strictures

Keywords: barrett's esophagus esophagus oct imaging
errors in prescription antibiotics in ventilator-associated pneumonia

Conditions: Pneumonia

Summary: the infection is a major risk to hospitalized patients, especially those admitted to the intensive care unit (icu) and an unfavorable factor in the outcome of critically ill patients, increasing costs and prolonging hospitalization hospitalar. the ventilator-associated pneumonia (pav) is considered the most prevalent nosocomial infection in the icu, occurring in 9% to 68% of patients with prosthetic ventilatória.due to the high rate of pav and mortality related to it, is very important both prescription and administration of antibiotics correctly, as deescalation or escalation according the result of cultures.therefore, the objectives of this study is assess if whether the antibiotic prescribed of ventilator-associated pneumonia following the orientation of literature. will also be assessed the rate of pav in patients critically ill adults, the main microorganisms responsible by pav and determining antimicrobial susceptibility.

in patients who had a diagnosis of ventilator-associated pneumonia by asssistente physician will be assessed initially prescribed antibiotics empirically and what conduct adopted after culture results. we will be examined whether the antibiotic prescribed following the orientation of literature, considering the dose, interval between doses, dose adjustment for renal failure infusion time, treatment time and conduct after the culture results (deescalation, escalation or maintenance of antimicrobial initially prescribed ) . the deescalation consists of discontinuing the use of antimicrobial or antibiotic change to another with lower coverage and spectrum is performed, escalation occurs when adding a new antibiotic or antibiotic to change the coverage of other larger spectrum after culture results .

Eligibility criteria:
inclusion criteria: * be 18 years of age; * having the diagnosis of ventilator-associated pneumonia. exclusion criteria: * be under 18 years of age;