Kornimate/medical-research-clean huggingface dataset:
autologous transobturator fascia lata sling in treatment of female stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: to evaluate the outcome of autologous transobturator fascia lata sling for treatment of female stress urinary incontinence at al-azhar university hospitals.

following induction of anesthesia and administration of perioperative antibiotics, the patient is positioned in the dorsal lithotomy position, sterilization and draping will be done. a sterile 16 french foley catheter is placed to drain the bladder, following this, injectable normal saline is utilized using 10 cc syringe for hydro-distention of the anterior vaginal wall, and a midline incision is made based on the mid-urethra. dissection is carried out bilaterally to the obturator foramen on both sides. through incision in the lower lateral aspect of the thigh, 4 cm above the knee, \~1 cm× \~5 cm fascial strip is isolated from the fascia lata. two stay sutures are secured to the corners of the fascial segment on each side. about 1cm skin incision is performed at the thigh fold on each side. next, two separate trocar passages are performed on each side using a reusable c-shaped trocar, with care taken to ensure at least a 1 cm tissue bridge in the obturator membrane between the superior and inferior passes. following this, the stay sutures are tied external to the obturator membrane on both sides, leaving the sling secured and flush with the mid-urethra. sutures are also placed to secure the sling to the periurethral tissue to prevent rolling or migration of the fascial strip.

Eligibility criteria:
inclusion criteria: * women with genuine stress urinary incontinence. * mixed urinary incontinence with predominant stress element. * refractory cases to conservative therapy or patients who are not willing to consider (further) conservative treatment. exclusion criteria: * mixed incontinence with predominant urge urinary incontinence. * associated local abnormalities that may affect surgery outcomes (e.g. complete procidentia). * recent or active urinary tract infection. * recent pelvic surgery. * neurogenic lower urinary tract dysfunction. * previous surgery for stress urinary incontinence. * pregnancy * less than 12 months post-partum. * other gynaecologic pathologies affecting bladder functions ( eg, large fibroids, ovarian cysts) * genito-urinary malignancy. * current chemo or radiation therapy.

Keywords: autologous tot sui stress
a long-term study of ym178 in symptomatic overactive bladder patients

Conditions: Urinary Bladder, Overactive

Summary: the study is intended to test the safety, tolerability, and efficacy of long-term treatment with ym178 in patients with overactive bladder symptoms.


Eligibility criteria:
inclusion criteria: * subject has symptoms of overactive bladder for \>= 24 wks * subject experiences frequency of micturition at average \>= 8 times per 24 hrs confirmed by the 3-day patient diary exclusion criteria: * subject is breastfeeding, pregnant, or intends to become pregnant during the study * subject obviously has stress incontinence * subject has an indwelling catheter or practices intermittent self catheterization * subject has evidence of symptomatic urinary tract infection, interstitial cystitis, bladder stone, etc * subject has an average total daily urine volume \> 3000 ml confirmed by patient diary * subject has uncontrollable hypertension (sbp \>= 180 mmhg or dbp \>= 110 mmhg)

Keywords: ym178 urinary bladder, overactive mirabegron
cubital tunnel syndrome and diffusion mri: a proof of concept study

Conditions: Cubital Tunnel Syndrome

Summary: cubital tunnel syndrome (cts) results from compression of the ulnar nerve at the elbow (colloquially termed the "funny bone"). cts affects up to 6% of the population and 6000 patients undergo surgery annually in the uk. surgery is the only proven treatment for cts, although up to 30% of patients do not improve. therefore, there is a pressing need to develop a reliable test to diagnose cts to improve the selection of patients for surgery. new techniques in the field of magnetic resonance imaging (mri) allow the visualisation of nerve structure and function. diffusion tensor mri, also known as diffusion tensor imaging (dti), can diagnose cts with superior diagnostic accuracy and could enable the reliable diagnostic of cts, improving the selection of patients for surgery. the study will include healthy volunteers (to refine the scanning sequence) and patients undergoing surgery for cts. patients will be scanned preoperatively and postoperatively using cutting-edge diffusion mri techniques. the primary outcome will be change in the mri-derived diffusion metrics following surgery. secondary outcomes will consider how mri relates to patient-reported outcomes and conventional clinical tests (ultrasound and nerve conduction studies). leeds is the ideal location for this research because a) leeds institutions are the most highly cited organisations in musculoskeletal research, b) leeds houses the national centre for hyperpolarized mri and a state-of-the-art mri scanner, and c) leeds is an internationally recognised centre of excellence for complex upper limb surgery.


Eligibility criteria:
inclusion criteria: * adults (over 18 years of age) undergoing surgical decompression of the ulnar nerve at the elbow for cubital tunnel syndrome. exclusion criteria: * unable to get into the mri scanner due to habitus or claustrophobia * unable to lie still due to any cause (eg. athetoid movements, dystonias, chorea, etc) * intraocular or intracranial metallic foreign bodies * active implants (eg. pacemakers, implantable cardiac defibrillators, nerve stimulators, etc) which are not mri safe or conditional. * pregnancy - whilst there are no known adverse effects of mri16-18 to the mother or fetus, mri is generally avoided in pregnancy due to the acoustic trauma19 and inductive heating generated by alternating magnetic fields. * any metallic implants in the elbow
anemia and pneumonia

Conditions: Pneumonia

Summary: assess prevalence of anemia among pneumonic children aged two months up to two years.

pneumonia is an infection via one or both lungs . bacteria and viruses are the most common causes. pneumonia can be medical emergency especially among high risk group like children less than five years iron deficiency anemia is one of the major health problem in young children. it may be associated with increased risk of pneumonia (1). a study conducted by bhaskaram reported high frequency of anemia 83 % in children with pneumonia (2). iron functions in the immune system are essential, among which are included: the maintenance of the activity of phagocyte oxidase, an iron excess can be used by bacteria to improve its growth (3). anemia was found to be independently associated with fatal outcome in pneumonic children (4). the risk of development of pneumonia in children with anemia increases approximately by four times in comparison with children who have no anemic syndrome (5). breast-feeding protects against lower respiratory tract infection because of breast milk's unique antiinfective properties (6). infants who were not being breast fed were 17 times more likely than those being breast fed without formula milk to be admitted to hospital for pneumonia (7). one of the factors that affects severe malnutrition is wrong parenting as parents can play an important role in their children's growth through proper, adequate feeding (8). there's no available studies that examine the association between anemia and pneumonia in our locality.

Eligibility criteria:
inclusion criteria: 1. inclusion criteria: children aged two months up to two years who attend to assiut university hospital with pneumonia in the outpatient pediatric clinic, emergency unit and from inpatient . exclusion criteria: * . exclusion criteria: all patients with other comorbidities will be excluded from our study as: severe sepsis \& localized infection e.g endocarditis, empyema, autoimmune diseases,renal diseases and congenital anomaly
biopsychosocial exploration of pain profiles in inflammatory and chronic non-specific axial low back pain

Conditions: Back Pain; Spondylitis, Ankylosing; Low Back Pain

Summary: the biopsychosocial model is well established in chronic low back pain (clbp) research. nevertheless, researchers to date have overlooked the biopsychosocial aspects of inflammatory low back pain (ilbp). most health care providers are biologically oriented in their treatment of ilbp, neglecting its possible multidimensional nature. it is true that people with ilbp may present with more complex pain and physical limitations than those with chronic non-specific low back pain (cnslbp), but it remains unexplored whether or not these limitations are affected by the same pain factors that affect cnslbp patients. this study aims to explore and compare the biopsychosocial back pain profiles of adults with ilbp and cnslbp.

this is a multicentre case-control study that will compare back pain in patients with ankylosing spondylitis and cnslbp. a multidimensional pain assessment will be conducted for patients in both groups. each patient will be assessed on one occasion by the same experienced physiotherapist.

Eligibility criteria:
inclusion criteria: * adult between 18 and 65 years of age * low back pain \>3 months * on stable medication * ability to walk independently without an assistive device * specific inclusion criteria for as group: clinical diagnosis of ankylosing spondylitis by a rheumatologist * specific inclusion for cnslbp group: clinical diagnosis by a physician for clbp exclusion criteria: * spinal surgery or compression fracture within the last 6 months * cauda equine and conus medullaris syndromes * severe musculoskeletal conditions affecting the upper and/or the lower limbs, such as severe inflammatory arthritis of the peripheral joints * severe osteoporosis * leg-length discrepancy * cancer * morbid obesity, or pregnancy * progressive neurological disease * psychiatric disease and/or cognitive limitations that could affect the ability to complete the study questionnaires * inability to read and/or understand the english language * severe cardiac, respiratory or neurological diseases * uncontrolled epilepsy * specific exclusion criteria for cnslbp group: spondyloarthropathy, or any structural abnormalities in the lumbar spine that result in serious neurological dysfunction, such as stage iii-iv lumbar disc herniation, and grade iii-iv spondylolisthesis

Keywords: inflammatory back pain ankylosing spondylitis non-specific low back pain pain experience disability behavioural psychological biopsychosocial pain profiles
neurofeedback for obsessive-compulsive disorder (ocd)

Conditions: Obsessive-Compulsive Disorder

Summary: the aim of this study is to train patients with obsessive-compulsive disorder to control a region of their brain that has been associated with their symptoms. patients in the experimental group will be given direct feedback regarding activity in this brain area while they are undergoing functional magnetic resonance imaging (fmri) scanning, and will try to learn to control activity in the region during these feedback sessions. a separate group of patients will be given a control form of feedback that we do not believe can have clinical benefits. our primary hypothesis is that the neurofeedback training will reduce ocd symptoms more than the control feedback.

original study design recruiting controls who were matched to the experimental group was changed to a randomized design prior to enrollment of the first participant.

Eligibility criteria:
inclusion criteria: * primary diagnosis of current ocd, based on diagnostic and statistical manual (dsm-iv) criteria, a y-bocs (yale-brown obsessive-compulsive scale) score \>=16 * principle ocd symptoms- primary symptoms must be either cleaning/contamination or checking; other symptoms okay * unmedicated (or medications stable for 8 weeks). * research group must be able to identify a target region in the orbitofrontal cortex that is related to symptoms exclusion criteria: * active psychosis; pervasive developmental disorder ; epilepsy or other major neurological disorder * history of major head trauma or psychosurgery * active substance abuse within 6 months * seizure disorder or other significant neurological disorder * active suicidality * pregnancy * severe claustrophobia, ferromagnetic metal in the body, a pacemaker or defibrillator, or any other condition that would make mri scanning unsafe or inappropriate * any psychotropic medication other than a selective serotonin reuptake inhibitor (ssri) antidepressant, anafranil, or a low-dose hypnotic or anxiolytic taken on an as-needed basis * active cognitive/behavioral therapy initiated within the last 3 months (continuation of established maintenance therapy that has been going on for longer than 3 months will not be grounds for exclusion)
evaluation of breathing effort in spontaneously breathing subjects

Conditions: Healthy

Summary: the aim of the research project is to evaluate the breathing effort using the work of breathing (wob) and pressure-time product (ptp) parameters, depending on the increasing flow resistance. the research project is concerned with assessing the increased (imposed) breathing effort using the work of breathing (iwob) and the pressure-time product (iptp). the main hypothesis tested is the differential effect of flow resistance on iwob and iptp parameters in spontaneous breathing of healthy probands.

due to the different calculation of iwob and iwob, these parameters may be affected at higher flow resistance values. the proposed experiment will be used to compare iwob and iptp obtained during spontaneous breathing to healthy subjects.

Eligibility criteria:
inclusion criteria: * healthy males and females \> 18 and \< 40 years old * signed informed consent has been obtained exclusion criteria: * respiratory disease * pregnancy * cardiovascular disease * diabetes mellitus

Keywords: work of breathing pressure time product imposed wob imposed ptp flow resistance
fast track rehabilitation following video-assisted lung segmentectomy

Conditions: Multiple Pulmonary Nodules

Summary: aim of this prospective randomized study is to assess the safety and efficacy of video-assisted lung segmentectomy (group b) comparing with mini muscle-sparing thoracotomy (group a) during diagnostic process for pulmonary nodules.


Eligibility criteria:
inclusion criteria: * patients with undiagnosed multiple pulmonary nodules exclusion criteria: * centrally located lesions * previous thoracotomy * extensive lung consolidation, and inability to achieve one lung ventilation

Keywords: lung nodule rehabilitation vats thoracotomy
cervix cytological screening - comparison of tampon self-test and the routine smear.

Conditions: Uterine Cervical Dysplasia; Uterine Cervical Neoplasms

Summary: the purpose of this study is to compare suitability, specificity and sensitivity of the routine smear and the tampon self-test women perform at home. study hypothesis: the tampon self-test correspond to the routine cervical smear.


Eligibility criteria:
inclusion criteria: 1. women with cervical dysplasia been referred to conisation or 2. women invited to cervical screening program exclusion criteria: 1. women not performing the tampon self-test before conisation or 2. women not performing the tampon self-test af least 1 month after receiving the tampon

Keywords: self test pap smear tampon test cervical dysplasia
impact of bridge™ device to treat opioid withdrawal symptoms

Conditions: Opioid Use Disorder

Summary: the purpose of this prospective study is to investigate the efficacy of the bridge™ device in reducing the symptoms of opioid withdrawal in a blind comparison to a sham device.


Eligibility criteria:
inclusion criteria: * participant able to provide written informed consent * participant is 18 to 65-years old * participant has confirmed opioid use disorder (oud) as defined by the diagnostic and statistical manual of mental disorders-5 * participants is entering an oud treatment program exclusion criteria: * participant requires tapering from another substance at entry to treatment * participant is pregnant or lactating * participant has a history of hemophilia or psoriasis vulgaris * participant has a cardiac pacemaker implant device * participant has irritated or broken skin at the site of intended device placement * participant is currently participating in, or was enrolled in another clinical trial within the last 30 days * participant has a history of poor wound healing * participant has a severe autoimmune disease or uncontrolled diabetes * participant has an open wound/abscess infection/mrsa * participant has a history of a chronic pain in the last 90 days * participant has a serious medical condition which in the judgment of the principal investigator or his/her designee would make study participation unsafe, or would make intervention compliance difficult * participant has a psychiatric illness (bipolar disorder, schizophrenia, or other psychotic disorder, active suicidal ideation with a plan within the last month or suicide attempt)
ed overcrowding validation study

Conditions: Emergency Department Overcrowding

Summary: the aim of this study is to externally validate a new emergency department overcrowding estimation tool (sonet) developed at john peter smith health network (jps).

in recent years, emergency department (ed) overcrowding has become more and more common in regional and tertiary referral hospitals. ed overcrowding status significantly affects ed operational efficiency, resulting in ambulance diversion, increased ed 72h return visits, patient satisfaction, and left without being seen (lwbs) rates. several estimation tools were derived to determine ed overcrowding status using various operational parameters such as, but not limited to, total number of ed patients, total ed admission holds, nursing staff, and patient injury severity. however, these tools cannot precisely evaluate ed overcrowding status, nor show strong correlations with ed operational inefficiency. the national emergency department overcrowding study (nedocs) is a widely used estimation tool to determine ed overcrowding status with relatively high consistency rates. however, the study was not able to evaluate interrater reliability since no standard definition of overcrowding existed. an ed overcrowding estimation tool, sonet, was developed and internally validated at jps and showed more consistency and accuracy when compared to estimation rates utilizing nedocs. all things considered, it is worthwhile to perform a survey study to determine the interrater variability between different evaluators for an ed overcrowding evaluation tool, one utilizing all possible collectible operational variables. in order to minimize the bias and further determine the accuracy of evaluating ed overcrowding status, a multi-center external validation study is warranted. this study will extend to six sites for the purpose of externally validating jps' novel ed overcrowding estimation tool, sonet, by comparing its overcrowding estimation rates with those derived utilizing nedocs.

Eligibility criteria:
inclusion criteria: * all adult patients visiting the emergency department or urgent care clinic at any one of the six participating sites during the allocated one month time period exclusion criteria: * those who do not meet inclusion criteria

Keywords: multicenter study emergency department overcrowding status estimation tool validation
clinical investigation to assess the feasibility of a new diabetes management program

Conditions: Type 1 Diabetes

Summary: the goal of this interventional study is to assess the adherence to a personalized care plan in patients (12-15 years) with type 1 diabetes


Eligibility criteria:
inclusion criteria: * male or female, 12-15 years of age. * t1d diagnosis minimum 8 months prior to the screening/initiation visit (visit 0). * equipped with continuous glucose monitoring (cgm) system, intermittent or real-time, either alone or associated with an insulin pump system * subject and health care provider must use a remote diabetes management platform for the upload and follow-up of cgm, pump data or hcl data (e.g.: glooko, diasend). * parent or guardian able and willing to give informed consent for the subject's participation in the investigation. exclusion criteria: * initiation of use of hcl system during the last 2 months or during the investigation. * use of medtronic insulin pump. * any disease or other medical condition, prior or concomitant medication /treatment /intervention, that may affect this clinical investigation or in other ways make the subject unsuitable for participation in this investigation, according to the judgement of the principal investigator (pi), or authorized designee. * participation in any clinical investigation or study within the previous 30 days, that may affect the safety or performance of this investigation. * mental incapacity precluding understanding or cooperation. * subject not able to read and communicate in swedish without an interpreter.
prevalence of post-traumatic stress disorder and trauma symptoms in a general population sample

Conditions: Post-traumatic Stress Disorder; Psychological Trauma

Summary: the goal of this observational study is to learn about how many people have post-traumatic stress disorder and related symptoms in the general population of people without any mental illness in the barcelona region of catalonia, spain. the main questions it aims to answer are: * what is the prevalence of post-traumatic stress disorder in a sample of healthy controls without other mental disorders? * what is the prevalence of trauma-related symptoms in a sample of healthy controls without mental illness? * what is the prevalence of dissociative symptoms (including symptoms of depersonalisation and somatoform dissociation) in a sample of healthy controls without mental illness? * what is the prevalence of recent and childhood traumatic life events in a sample of healthy controls without mental illness? * what is the prevalence of difficulties in psychosocial functioning in healthy controls without mental illness? * what is the prevalence of depressive symptoms in healthy controls without mental illness? * what is the prevalence of general psychiatric symptoms in healthy controls without mental illness? participants will be asked to take part in an online screening programme, and then to come to an interview with a clinician who will apply validated scales to test the above.

this is a study to provide normative data for the prevalence of traumatic life events, post-traumatic stress disorder and trauma-related symptoms, and their impact on psychosocial functioning, and affective symptoms in healthy controls (i.e. without mental illness) in the barcelona region of catalonia, spain.

Eligibility criteria:
inclusion criteria: * to be an adult (18-65 years inclusive) exclusion criteria: * to have a mental disorder except for post-traumatic stress disorder, determined by application of the mini international neuropsychiatric interview (mini) * active suicidal ideation * presence of organic brain disease * presence of somatic diseases such as fibromyalgia or chronic fatigue syndrome * presence of autoimmune diseases such as hiv or aids

Keywords: post-traumatic stress disorder psychological trauma healthy controls