Kornimate/medical-research-clean huggingface dataset:
effect of selenium supplementation on inflammatory,oxidative and nutritional markers in hemodialysis patients

Conditions: Inflammation; Malnutrition; Complication of Hemodialysis

Summary: the aim of this study is to evaluate the effect of selenium supplementation on oxidative, inflammatory and nutritional markers in hemodialysis patients.

after screening all of 280 patients under regular hd in faghihi hospital hemodialysis center, 80 stable patients in the age range of 18-80 years old were found to be eligible for enrollment and gave their informed consent to participate in this trial. subjects were excluded if they were prescribed any multivitamins or immunosuppressive drugs or taking antioxidant supplements including vitamin e, vitamin c, lipoic acid, omega-3 fatty acids, soy extracts and green-tea preparations within 2 months prior to enrollment in the study or if they had been hospitalized in the previous month, we also excluded the ones who were pregnant or had active infections. the ethics committee of shiraz university of medical sciences reviewed and approved the protocol of this study.these patients were randomly assigned in a 1:1 ratio into 2 groups of selenium(200µg) or placebo and were followed for 12 weeks.in order to determine the nutritional statuses of all patients, at the baseline, the questions of sga and mis questionnaire were read to the patients and completed in person by the main investigator. the questions of sga and mis were also asked by the same person at the end of treatment phase.before the onset of the treatment and after the end of the treatment phase of the study, 10cc blood samples were taken from each patient.the blood was taken from the patient's arm used for hemodialysis cannula just before the beginning of the hemodialysis procedure. the serum was separated by centrifugation at 3000 g/min for 5 min and stored at -70°c. serum levels of malondialdehyde (mda), interleukin-6 (il-6), high sensitive c-reactive protein (hscrp), ferritin, transferrin, homocysteine, calcium , phosphate, parathyroid hormone (pth), albumin, blood urea nitrogen (bun), and creatinine as well as hemoglobin (hb) levels were measured in all patients at the baseline and at the end of treatment phase of study.the aim of this study was to evaluate the effect of selenium supplementation on oxidative, inflammatory and nutritional markers in hemodialysis patients.

Eligibility criteria:
inclusion criteria: * patients who were dialyzed three times a week at least for 3 months or more exclusion criteria: * patients who took any multivitamins or immunosuppressive drugs within 2 months prior to enrollment in the study * patients consuming antioxidant supplements including vitamin e, vitamin c, lipoic acid,omega-3 fatty acids, soy extracts and green-tea preparations within 2 months prior to enrollment in the study * patients who were hospitalized in the previous month * patients who had active infections * being pregnant

Keywords: hemodialysis oxidative stress selenium inflammation
in vivo confocal microscopy tumor atlas study

Conditions: Brain Neoplasms

Summary: this study aims to create an atlas based on the preliminary experience of the first feasibility study in neurosurgery. hypothesis: that a confocal endomicroscope can be used during neurosurgery to provide in vivo histology that enables documentation of neurological pathology across a range of tumor ypes and grades, suitable for comparison with traditional histopathology from site-matched biopsies.

confocal endomicroscopy is a medical imaging modality that allows real-time microscopy to be performed on living tissue in vivo. the procedure involves a small endoscope which is placed gently into contact with the tissue, providing significant in vivo magnification on a scale similar to that obtained by the pathology laboratory microscope. it is already in clinical use in the field of gastroenterological endoscopy, and investigational use in laparoscopy, dermatology and gynecology. further, in recent pilot studies endomicroscopy has also been shown to be feasible in bronchoscopy, robot assisted prostatectomy and neurosurgery.the study will use both endomicroscopy and biopsy to document the histological appearance of a range of neurological tumour types and grades. in subsequent analysis, the confocal image data and corresponding histology data and images will be used to document reliably observable features in the confocal images that are relevant to histopathology interpretation. relevant images will be selected and discussed by comparison to frozen or permanent section histology for compilation into an atlas documenting comparison for the tumors seen in the study.

Eligibility criteria:
inclusion criteria: * all patients with neurological pathology requiring surgery in which tumour resection might be evaluated by using biopsy exclusion criteria: * history of allergy to fluorescein * patients on beta-blockers or ace inhibitors * pregnant women * inability to give informed consent
improving pharmacological transition of palliative care patients from inpatient to outpatient care

Conditions: Cancer; Heart Failure; COPD

Summary: the transition of palliative care patients from inpatient to outpatient care is aimed to be improved through structured pharmaceutical discharge management by a trained pharmacist. this data will be compared with retrospective cases.

as part of a prospective observational study with a retrospective comparison group, a pharmacist should, on request, check the discharge medication planned by the primary care physicians before discharge and discuss it with the various colleagues providing (follow-up) care. in addition, the availability in the outpatient "medicine cabinet" and the possibility of prescribing by the responsible gps (by telephone) should be checked in advance. in addition, longitudinal focus groups with relevant stakeholders are to be conducted to collect quantitative data as well as qualitative data on the views of those providing and receiving treatment. there will be cooperation with the specialized outpatient palliative care service muenster to ensure sufficient case numbers and a low rate of missing values through partial use of the standard care data from the "information system palliative care" (ispc) program they use.

Eligibility criteria:
inclusion criteria: all individual indications for general and specialised palliative care as part of routine clinical practice (e.g.): * advanced, malignant tumour disease * advanced, chronic obstructive pulmonary disease * patients with advanced disease and limited life expectancy (approx. 12 months) further care in the sopc muenster (prospective data) sufficient understanding of the german language to be able to understand the information and consent form exclusion criteria: impossibility of understanding the information and declaration of consent.

Keywords: palliative care
spinal anesthesia for external cephalic version

Conditions: Breech Presentation; Before Labor

Summary: this study evaluates the potential benefits of spinal anaesthesia for nulliparous mothers scheduled for external version of babies in breech position.

fetuses in breech position are almost always delivered by caesarian section (cs). if the fetus is in breech position by the end of pregnancy, attempts for external cephalic version (ecv) are usually made. the success rate of ecv in nulliparous women is lower than in multiparous women. there are studies showing a higher rate of successful ecv's if the mother received a low dose spinal anaesthesia (sa). overall maternal satisfaction was higher with sa. these studies, however, did not take parity into account. the primary aim of this study is to see if sa can increase the rate of successful ecv's in nulliparous women. the secondary aims are to evaluate if maternal satisfaction increases and if the rate of cs is decreasing using sa during ecv.

Eligibility criteria:
inclusion criteria: * pregnant nulliparous women. * breech presentation of fetus, eligible for external version. exclusion criteria: * unwilling to participate. * unable to understand written and oral swedish in the absence of interpreter. * contraindications to spinal anaesthesia.

Keywords: breech presentation, external version, spinal anaesthesia
topical collagen-silver versus standard care following removal of ingrown nails

Conditions: Ingrown Nail

Summary: this study's purpose is to prospectively determine whether topical therapy with an oxidized regenerated cellulose collagen-silver compound is more effective than the current standard of topical antibiotic therapy for care following the removal of an ingrown toenail. eighty adult patients with ingrown toenails will be recruited. each patient will randomly be assigned to apply either topical silver sulfadiazine cream (standard antibiotic) or the novel collagen-silver compound to their nail bed daily, following removal of the ingrown portion of nail. patients will return for follow up visits weekly, until healing has occurred or twelve weeks have passed. healing will be defined as resolution of drainage and inflammatory changes surrounding the nail border.


Eligibility criteria:
inclusion criteria: * ingrown toenails will be defined as any incurvated nail border that digs into the skin of the nail fold and causes pain and discomfort exclusion criteria: * patients with immunocompromised states * chronic steroid use * diabetes mellitus * collagen vascular disease * hiv infection * cellulitis proximal to the hallux interphalangeal joint or peripheral vascular disease will be excluded * we will define peripheral vascular disease as the absence of one or more pedal pulses or the presence of dystrophic changes to the integument

Keywords: chemocautery
prognostic study of visceral fat and heart failure with preserved ejection fraction

Conditions: Heart Failure With Preserved Ejection Fraction and Visceral Fat

Summary: obesity and heart failure with preserved ejection fraction (hfpef) have multiple pathologic associations that affect the prognosis of hfpef. chinese people are more prone to visceral obesity, resulting in varying degrees of true obesity in individuals with the same body mass index (bmi). there are no prognostic studies of vfa/bmi in the hfpef population.

a total of 298 patients with hfpef who were hospitalized in the department of cardiovascular medicine of the first affiliated hospital of chongqing medical university from september 2020 to august 2023 were included in this prospective cohort study.all patients were followed up on november 30, 2023.the primary endpoint of the study was all-cause mortality and secondary endpoints were rehospitalization for heart failure and composite endpoints of both.after a median follow-up of 564 days, a total of 30 (10.1%) patients died and 82 (27.5%) were rehospitalized for heart failure. patients with hfpef were categorized into two groups according to median vfa/bmi (vfa/bmi \<5.49; vfa/bmi ≥5.49).the aim of this study was to elucidate whether vfa/bmi has prognostic value in patients with hfpef by kaplan-meier survival analysis and cox regression analysis.

Eligibility criteria:
inclusion criteria: * adule aged≥18 years old; * diagnosed with hfpef. diagnostic criteria including: 1. left ventricular ejection fraction ≥50%; 2. with signs and/or symptoms of heart failure; 3. sinus rhythm：bnp≥35pg/ml and/or nt-probnp≥125pg/ml;atrial fibrillation rhythm：bnp≥105pg/ml and/or nt-probnp≥365pg/ml； 4. at least one additional criterion: relevant structural heart disease(lvh and/or lae) or diastolic dysfunction. exclusion criteria: * age ≤18 years; * malignant tumor; * comorbid severe hepatic and/or renal insufficiency; * lost to follow-up.
high-fat meal challenge in pediatrics

Conditions: Pediatric Obesity; Insulin Resistance

Summary: the objective is to determine if how physical fitness, measured using a treadmill maximal oxidative capacity test, is associated with the capacity to metabolize a high-fat meal in pediatrics (ages 8-17 years). ability to metabolize the meal will be assessed by profiling mitochondrial and extra-mitochondrial fatty acid metabolites. the investigators will test if fatty acid oxidation mediates the relationship between fitness and markers of metabolic health, such as insulin resistance.


Eligibility criteria:
inclusion criteria: * children ages 8-17 years with a bmi-percentile ≥ 5th. exclusion criteria: * previous diagnosis of type 1 or 2 diabetes. * use of concurrent medications known to affect glucose metabolism (metformin, oral steroids, sulfonylureas, insulin). * evidence of inherited disorders of lipid metabolism. * inability to participant in the maximal aerobic capacity test on the treadmill. * allergies to palm oils or protein types within high-fat challenge, such as lactose and soy. * individuals who cannot speak and/or write in english.
a study of tirzepatide (ly3298176) compared with dulaglutide on major cardiovascular events in participants with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.


Eligibility criteria:
inclusion criteria: * have a diagnosis of type 2 diabetes * have confirmed atherosclerotic cardiovascular disease * hba1c ≥7.0% to ≤10.5% * body mass index (bmi) ≥25 kilograms per meter squared (kg/m²) exclusion criteria: * have had a major cardiovascular event within the last 60 days * have type 1 diabetes mellitus * have a history of severe hypoglycemia and/or hypoglycemia unawareness within the last 6 months * are currently planning treatment for diabetic retinopathy and/or macular edema * currently planning a coronary, carotid, or peripheral artery revascularization * have a history of pancreatitis * have a history of ketoacidosis or hyperosmolar state/coma * have a known clinically significant gastric emptying abnormality, have undergone or currently planning any gastric outlet obstruction, or have undergone or currently planning any gastric bypass (bariatric) surgery or restrictive bariatric surgery * have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years * have a family or personal history of medullary thyroid carcinoma (mtc) or multiple endocrine neoplasia syndrome type 2 (men-2) * have had a blood transfusion or severe blood loss within 90 days prior to screening or have known hematological conditions that may interfere with hba1c measurement

Keywords: diabetes mellitus diabetes mellitus, type 2 glucose metabolism disorders metabolic diseases endocrine system diseases hypoglycemic agents physiological effects of drugs tirzepatide incretins glucagon-like peptide 1 gastric inhibitory polypeptide hormones hormones, hormone substitutes, and hormone antagonists
oxaliplatin/cpt-11 for extensive stage small cell lung cancer

Conditions: Small Cell Lung Cancer

Summary: the purpose of this study is to determine the safety and effectiveness of the combination of oxaliplatin and irinotecan (cpt-11) in patients with previously untreated, advanced small cell lung cancer.


Eligibility criteria:
inclusion criteria: * previously untreated extensive small cell lung cancer * no prior chemotherapy * no prior radiotherapy except for the treatment of brain metastases exclusion criteria: * prior treatment for extensive stage small cell lung cancer * known hypersensitivity to any of the components of oxaliplatin or cpt-11 * greater than grade 2 peripheral neuropathy * known hiv or hepatitis b or c (active, previously treated or both)
a study of first line treatment with tarceva (erlotinib) in combination with gemcitabine in patients with locally advanced unresectable or metastatic pancreatic cancer

Conditions: Pancreatic Cancer

Summary: this single arm study will assess the efficacy and safety of tarceva + gemcitabine in patients with locally advanced, unresectable or metastatic pancreatic cancer. patients will receive tarceva 100mg po daily, in combination with gemcitabine 1000mg/m2 iv weekly for 8 weeks, followed by weekly for 3 weeks of each 4 week cycle. the anticipated time on study treatment is until disease progression, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * pancreatic cancer, surgically unresectable or with metastases; * no previous chemotherapy (except concomitant with radiotherapy); * ecog 0-2. exclusion criteria: * pancreatic cancer without histologic or cytologic confirmation; * surgical resection possible; * previous chemotherapy not concomitant with radiotherapy; * ecog 3-4.
the effect of classical music on dental students' stress and anxiety during the covid-19 pandemic

Conditions: Psychological Factors

Summary: the students adapted to the environment for the first 2 days, were informed about the study, and their informed consent was obtained. participants were asked to answer all questions and to give a single answer to each question. the students filled in the questionnaire form used in the study without any intervention by the researcher. participants filled out the same survey four times at different times following a specific protocol.

the study was conducted with a specific protocol. first, they were asked to complete a questionnaire including socio-demographic data, perceived stress scale (pss-14), and coronavirus anxiety scale (cas) before patient admission (t1). the students were asked to complete the same questionnaire at the end of the day after working for 2 days (t2) and in the morning on the 5th day of their study before seeing patients (t3). each of the students participating in the study was given disposable headphones every day during the week of music listening. in this study, beethoven's moonlight sonata (1 hour 2 minutes) mozart's serenata notturna kv239 (12.50 minutes) and pachelbel's canon in d major (6.16 minutes)were used. it was shared with the students via whatsapp and they were allowed to listen to this music on their phones for 1 week (2 hours on average) during the study period. the same questionnaire was refilled at the end of the week in which music was played (t4).

Eligibility criteria:
inclusion criteria: * aged 20 years and over, * systemically healthy and drug-free, * students who were obliged to practice in the clinic of the department of periodontology, faculty of dentistry, ankara university, within the scope of the education program exclusion criteria: * systemic diseases * medication use

Keywords: beethoven coronavirus anxiety music mozart perceived stress
reducing disability via a bundled bio-behavioral-environmental approach

Conditions: Quality of Life

Summary: the purpose of the study is to determine whether a combination of occupational therapy visits, nursing visits, and handyman repair are effective in helping low income older adults avoid costly health care services

we will recruit low-income age 65 or older -principally african-american, adults from the baltimore department of housing energy assistance program. -we will interview them at home and randomize participants to either the treatment (capable intervention) or control (attention-control) group. participants in the treatment group will receive up to 10 in-home sessions -- 6 visits with an occupational therapist and 4 visits from a nurse - and $1200 in safety and modification services from a licensed handyman. each treatment participant will receive each intervention component but interventionists will systematically tailor content to the participants' risk profile and goals based on protocols.

Eligibility criteria:
inclusion criteria: * at least 65 years old * cognitively intact * difficulty with at least one activity of daily living or two instrumental activities of daily living * less than 175% of the federal poverty level * be able to stand with or without assistance * agree to study participation exclusion criteria: * hospitalized more than three times in the last year * receiving in home rehabilitation * have a terminal diagnosis with less than one year life expectancy * plan to move in less than one year

Keywords: quality of life
hypofractionated palliative radiotherapy in patients with advanced non-operable rectal cancer

Conditions: Rectal Cancer

Summary: many patients with rectal cancer were not candidates for surgical resection because advanced age, comorbidities, or multiple synchronous metastases. in this scenario only comfort measures or different palliative radiotherapy regimens are applied, from single doses to treatments lasting several weeks. the aim of this prospective study is to describe the preliminary results of our protocol of hypofractionated palliative radiotherapy in patients with non-operable rectal cancer.

many patients with rectal cancer were not candidates for surgical resection because advanced age, comorbidities, or multiple synchronous metastases. in this scenario only comfort measures or different palliative radiotherapy regimens are applied, from single doses to treatments lasting several weeks. the aim of this prospective study is to describe the preliminary results of our protocol of hypofractionated palliative radiotherapy in patients with non-operable rectal cancer. patients with rectal cancer who were not candidates for surgical resection because advanced age, comorbidities, or multiple synchronous metastases at the time of diagnosis were considered eligible. patients were immobilized in the prone position with a belly-board in order to reduce small bowel irradiation. to limit organ motion patient were instructed to empty the bladder and drink 500cm3 of water 45-60 minutes before ct simulation and before every treatment fraction. a conformal three-dimensional radiotherapy technique was planned to deliver to the primary tumor and the enlarged pelvic nodes a total dose of 39gy in 13 sessions of 3gy in 17 days. symptomatic response after the end of treatment has been measured for bleeding and pain and acute toxicity were reported according to ctcaev4.0 scale.

Eligibility criteria:
inclusion criteria : 1. patients with rectal or sigmoidal cancer who were not candidates for surgical resection because advanced age, comorbidities, or multiple synchronous metastases at the time of diagnosis 2. patients with = or \> 18 years old 3. patients treated with a radiotherapy dose of 39gy in 13 fractions of 3 gy exclusion criteria: 1. patients with a non rectum or sigma colo-rectal cancer. 2. patients with \<18 years old. 3. patients treated with concurrent chemotherapy 4. patients candidates for surgical resection after radiotherapy

Keywords: palliative radiotherapy rectal bleeding hypofractionated radiotherapy