Kornimate/medical-research-clean huggingface dataset:
epidemology of acute kidney injury in diabetic patients infected with covid_19 in assiut university hospital

Conditions: Acute Kidney Injury Due to covid_19

Summary: the novel coronavirus sars-cov-2 was identified as the causative agent for a series of atypical respiratory diseases in wuhan, china in december of 2019(.1) the disease termed covid-19, was officially declared a pandemic by the world health organization on march 11, 2020. sars-cov-2 contains a single-stranded, positive-sense rna genome surrounded by an extracellular membrane containing a series of spike glycoproteins resembling a crown.covid-19 infection results in diverse symptoms and morbidity depending on individual genetics, ethnicity, age, and geographic location. in severe cases, covid-19 pathophysiology includes destruction of lung epithelial cells, thrombosis, hypercoagulation, and vascular leak leading to sepsis.(2) covid-19 risk factors include cardiovascular disease, hypertension, and diabetes.(2)

notably, in several studies, diabetes is one of the most reported comorbidities with poor prognosis in patients with severe covid-19 due to compromised innate immunity, pro-inflammatory cytokine reduced expression of ace2 and use of renin-angiotensin-aldosterone system antagonists. (3) on the other hand, covid-19 contributes to worsening of dysglycemia in people with diabetes mellitus by direct β-cell damage, cytokine-induced insulin resistance, hypokalemia and drugs used in the treatment of covid-19 (like corticosteroids, lopinavir/ritonavir).(4) nearly half of critically ill patients would develop aki at some point during their icu admission.(5) acute kidney injury (aki) has been reported to be the second observed complication in deceased patients after ards.it is reported that patients who died with covid19 had different degrees of aki .the pathogenesis of kidney injury in patients infected with covid19 is multifactorial: (1) prerenal azotemia, atn can occur owing to many contributing factors including volume depletion, cytokine storm, hypoxia, shock, or rhabdomyolysis (2) proximal tubular injury, (3) glomerulopathy, (4) thrombotic microangiopathy, and (5)complications from the treatment of covid_19. (6)

Eligibility criteria:
inclusion criteria: * patients admitted because of covid-19 infetion. exclusion criteria: * patients with esrd on regular dialysis ,patients with stage 4 or 5 non-dialysis if the condition proven to be progression of the already known diagnosis.
association between sarcopenia and diabetic neuropathy in adults with type 1 diabetes, a pilot study

Conditions: Type 1 Diabetes

Summary: monocentric interventional prospective study to evaluate the prevalence of sarcopenia in adults with type 1 diabetes (t1dm) and to evaluate the association between diabetic neuropathy and sarcopenia in subjects with t1dm; to evaluate the prevalence of dynapenia in adults with t1dm and its association with diabetic neuropathy.


Eligibility criteria:
inclusion criteria: 1. age 50-80 years, both sexes 2. diagnosis of t1dm for at least 10 years, in both multiple daily injections of insulin (mdi) and continuous subcutaneous insulin infusion (csii) 3. informed consent before any study activity 4. ability to fully perform all protocol activities exclusion criteria: 1. previous diagnosis of t2dm 2. previous diagnosis of dementia 3. presence of heart failure (nyha class iii and iv) 4. presence of muscular disease 5. diagnosis of neurodegenerative disease (e.g. multiple sclerosis, parkinson's disease) 6. egfr evaluated through ckd-epi formula \<20 ml/min /1.73m2 , estimated on previous creatinine dosage 7. previous history of stroke or cerebrovascular disease 8. diagnosis of coeliac disease 9. diagnosis of chronic inflammatory bowel disease 10. untreated hypothyroidism or hyperthyroidism or not well controlled hypothyroidism or hyperthyroidism with current therapy (tsh \>5 or tsh \<0.15) 11. alcohol abuse or consumption of more than 14 alcoholic units weekly 12. active cancer or therapy 13. pregnancy 14. primary hyperparathyroidism 15. corticosteroid and/or estrogen-progestogen therapy for at least 12 months in medical history 16. on going treatment with antiretroviral therapy 17. on going treatment with immunosuppressive therapy, e.g. cyclosporine, tacrolimus 18. on going treatment with anti-epileptic drugs
effectiveness and cost-efficiency of aquatic exercise for management of osteoarthritis

Conditions: Osteoarthritis

Summary: the purpose of this study was to estimate the cost and outcomes of the arthritis foundation aquatic exercise classes. * design. randomized trial of 20-week aquatic classes. * subjects and methods. recruited 249 adults from washington state aged 55 to 75 with a doctor-confirmed diagnosis of osteoarthritis * meaures. the quality of well-being scale (qwb), current health desirability rating (chdr), health assessment questionnaire(haq), center for epidemiologic studies-depression scale (ces-d), perceived quality of life scale (pqol)


Eligibility criteria:
inclusion criteria: * clinically confirmed diagnosis of osteoarthritis from a physician * aged 55 to 75 * not currently exercising, defined as engaging in an average of less than 60 minutes of exercise/week during the last month * permission of the subject's primary physician to participate in the aquatic class * not currently enrolled in another medical study * not scheduled for joint replacement surgery during the study period * living in an area where arthritis foundation aquatic programs were offered * willingness to be randomized and to commit to the 5-month study period

Keywords: osteoarthritis
development of clinical database of individuals with smith-magenis syndrome and sleep disturbances

Conditions: Sleep Disturbances in Smith-Magenis Syndrome

Summary: this database will be used to better understand the sleep problems of people with sms. this clinical database will be a part of a larger smith-magenis patient registry used to create an awareness campaign around sms and the sleep disturbances that are characteristic of the disorder.


Eligibility criteria:
inclusion criteria: * parent or legal guardian of individual with smith-magenis syndrome exclusion criteria: * not legal guardian of individual with sms
prp efficacy and safety in bpf

Conditions: Bronchopleural Fistula

Summary: platelet-rich plasma(prp), is a concentrate of platelet-rich plasma protein derived from whole blood. the main components of it are platelets, leukocytes and fibrin. autologous prp treatment can avoid the immune rejection caused by exogenous growth factor and the spread of disease. evidence of the efficacy and safety of prp has been proven in many studies. bronchopleural fistula (bpf) represents a challenging clinical entity characterized by abnormal communication between the bronchial tree and the pleural space. respiratory intervention has become one of the most common treatments to fight the disease. although the short-term occlusion effect of conventional treatment methods of respiratory intervention is relatively easy to achieve, there is great uncertainty in the long-term treatment effect, and long-term large fistulas have little chance of healing. prp has shown significant efficacy for hyperplastic scar of skin. correspondingly, prp will be applied as treatment of bpf to cure fistula.


Eligibility criteria:
inclusion criteria: * subjects with aged between 18 to 75 * subjects diagnosed with bronchopleural fistula (the sizes of the fistulas less than 4mm) * subjects willing to accept prp treatment exclusion criteria: * subjects with fistulas larger than 4mm * subjects who cannot tolerate bronchoscopy due to severe cardiac disease or other major comorbidities * pregnant or breastfeeding women

Keywords: bronchopleural fistula platelet-rich plasma
acute-acute surgical care- risk factors and outcomes for patients in need of acute surgical care

Conditions: Risk Factors; Complication of Surgical Procedure; Complication of Treatment; Complication of Anesthesia; Long Term Effects After Emergency Surgery; Long Term Effects After GI Bleeding

Summary: observational retrospective study of patients in need of acute surgical care admitted to skåne university hospital between 2009 and 2019.

at skåne university hospital approximately 6000 individuals are treated for acute abdominal diseases each year. given the high number of patients, there is an urgent need to optimize acute surgical care. lower complication rates would decrease hospital stay, health care costs as well as personal suffering. assessment instruments for risks and frailty are not validated for the acute setting and the investigators hypothesize there is room for improvement in prophylactic interventions and risk assessment. the investigators will study cohorts of patients with three different surgical diagnosis: acute pancreatitis, gastrointestinal bleeding and perforated ulcer aiming to identify risk factors for complications or death and to investigate assessment tools in this population. using propensity score analysis, the investigators will try to identify treatment options associated with better outcome for subcohorts defined by frailty, comorbidity, age or gender. specific factors of interest include: time to- and kind of treatment, handling of ongoing pharmacological therapy (anticoagulants, corticosteroids) and need for further treatments on a long time basis. the results from this project will be used in a future prospective study where prophylactic treatments and specific treatment options are studied.

Eligibility criteria:
inclusion criteria: patients admitted to skåne university hospital in need of acute surgical care - exclusion criteria: below 18 years old -

Keywords: emergency surgery acute surgery complications risk factors frailty ageing
quadruple and phytomedicine-based therapies in h. pylori infection

Conditions: Helicobacter Pylori [H. Pylori] as the Cause of Diseases

Summary: helicobacter pylori is strongly associated to the development of gastrointestinal disorders. emerging antibiotic resistance and poor patient compliance of modern therapies has resulted in significant eradication failure. clinical trial was conducted to see the efficacy of current quadruple and phytomedicine-based therapies for the eradication of h. pylori infection and relief in its associated symptoms in pakistan.


Eligibility criteria:
inclusion criteria: 1. the patients suffering from h. pylori infection 2. patients having no previous record of treatment against h. pylori infection 3. patients living in karachi, rawalpindi and bahawalpur 4. patients having no pathological complications on routine examination 5. all socioeconomic classes were included in the study 6. male and female patients between 15 to 45 years of age exclusion criteria: 1. there was peptic ulceration, gastrointestinal bleeding or gastric carcinoma 2. if history of use of antibiotics, proton-pump inhibitors or bismuth compound in the last one month before test 3. any patient found to be allergic or intolerant to therapeutic regimens 4. they failed to report for follow-up
the 10-year follow-up of the delta-tt trial.

Conditions: Hip Dislocation

Summary: this 10-year follow-up study aims to further investigate long-term migration patterns of the uncemented delta-tt cup and h-max s stem, comparing outcomes between ceramic and polyethylene liners. given the predictive value of early rsa migration patterns at the 2-year mark for identifying implants at risk of aseptic loosening, we hypothesize that the delta-tt cup will demonstrate good stability at the 10-year postoperative mark. besides, it is hypothesized that migration of delta tt-cups is comparable between ceramic and polyethylene liners. the primary objective of this study is to measure the long-term stability of the delta tt cup, combined with either a ceramic or cross-linked polyethylene liner, by means of rsa at 10-years postoperatively. secondary objectives are to measure long-term stability of the h-max s stem, by means of rsa at 10-year postoperatively. furthermore the study aims to measure implant survival rates and patient-reported outcomes for both the delta-tt cup and h-max s stem, comparing outcomes between the ceramic and polyethylene group.


Eligibility criteria:
inclusion criteria: * enrolled in the initial delta-tt trial exclusion criteria: * patient is unable or unwilling to sign the informed consent specific to this study. * patient is unsuitable for participation in the study based on the investigator's judgement.
virtual chromoendoscopy with second generation nbi (hq190) vs chromoendoscopy in inflammatory bowel disease

Conditions: Chromoendoscopy

Summary: study to compare the detection of neoplastic lesions between chromoendoscopy and nbi

single-blind (patient) randomized study to compare detection of neoplastic lesions between chromoendoscopy and nbi. patients with inflammatory bowel disease who are to undergo chromoendoscopy according to usual clinical criteria will be included. the endoscopic procedure is similar to the one usually performed. all patients will undergo colonoscopy according to the usual procedure, with olympus hq190 series endoscopes, with the same bowel preparation. during intubation, the faecal remains will be thoroughly washed. patients will be randomly assigned to one of the two techniques: chromoendoscopy with 0.1% methylene blue or new generation nbi with near focus. biopsies will be taken of all those lesions detected, instead of random biopsies.

Eligibility criteria:
inclusion criteria: * patients with an established diagnosis of inflammatory bowel disease with indication to undergo chromoendoscopy exclusion criteria: * patients who are not trained to understand the nature of the study, the procedures to be followed or are not able to sign an informed consent * known allergy or intolerance to methylene blue * pregnant or lactating women * personal history of colorectal cancer * ulcerative colitis active more than 20 cm from the anal verge * patients with known g6pd deficiency * severe kidney failure
cost-utility of virtual fibrowalk

Conditions: Fibromyoma;Cervix

Summary: the main objective of this study is to assess the effectiveness and cost-utility of the virtual fibrowalk multicomponent treatment program as coadjuvant of treatment-as- usual (tau) compared to tau alone.

this is a two-arm rct focused on the effectiveness and cost-utility of the multicomponent program virtual fibrowalk as coadjuvant of treatment-as- usual (tau) vs. tau alone (in a 3-month follow-up rct) virtual fibrowalk combines multicomponent approach based on pain neuroscience education (pne), therapeutic exercise, cognitive behavioural therapy (cbt) and mindfulness training.

Eligibility criteria:
inclusion criteria: * adults from 18 to 75 years-old. * 1990 american college of rheumatology (acr) classification criteria + the 2011 modified acr diagnostic criteria for fibromyalgia * able to understand spanish and accept to participate in the study. exclusion criteria: * participating in concurrent or past rcts (previous year). * comorbidity with severe mental disorders (i.e. psychosis) or neurodegenerative diseases (i.e. alzheimer) that that would limit the ability of the patient to participate in the rct.

Keywords: cost-utility fibromyalgia multicomponent treatment randomized controlled trial
study on the effect of intravenous ascorbic acid on intraoperative blood loss in women with uterine myoma

Conditions: Uterine Leiomyoma

Summary: the investigators want to know whether the intravenous ascorbic acid would reduce the blood loss during laparoscopic myoma surgery. the investigators randomized patients into intravenous ascorbic acid group and placebo group and examined the blood loss in both groups.


Eligibility criteria:
inclusion criteria: * uterine myoma * be planning to laparoscopic myomectomy * images ; the number of myoma \<4 * images ; the diameter of the largest myoma \<9cm exclusion criteria: * be planning other surgery in addition to laparoscopy * clinically significant coagulation abnormality

Keywords: uterine leiomyoma laparoscopic myomectomy intraoperative blood loss ascorbic acid
real-time fmri feedback effects on pain perception

Conditions: Cognitive Pain Control

Summary: the purpose of this study is to determine whether real-time functional magnetic resonance imaging may be a viable treatment for chronic pain in the future.

twenty-four healthy volunteers will undergo a series of four fmri scanning sessions wherein thermal pain stimuli will be used to elicit activation of the pain neuro-matrix. all participants will undergo thermal pain threshold testing before and after fmri scan. participants will also rate the painfulness and unpleasantness of the thermal stimuli applied before fmri and after fmri. all participants will be given prompts to apply a set of cognitive pain-control strategies. half of the participants will receive real-time fmri feedback of activity in the right anterior cingulate cortex (racc) and the other half will receive real-time fmri feedback of activity in the prefrontal cortex (pfc). it is hypothesized that those receiving real-time feedback of brain activity thought to be involved with analgesic effects will demonstrate greater analgesia associated with the application of the cognitive control techniques after fmri paradigm (decreased pain intensity and unpleasantness ratings and increased thermal pain thresholds) than those who are not given feedback before fmri paradigm.

Eligibility criteria:
inclusion criteria: * healthy adults ages 18-65 exclusion criteria: * clinical depression * anxiety * substance dependence or chronic pain * ferrous metal implants * cardiac pacemakers or other implanted medical devices that might be adversely impacted by the mri scanner magnetic field

Keywords: pain fmri real time
diastolic dysfunction ppcm in patients with documented left ventricular systolic function recovery

Conditions: Peripartum Cardiomyopathy; Diastolic Dysfunction

Summary: the purpose of this project is to evaluate parameters of diastolic dysfunction assessed by clinical echocardiogram in patients who have had recovery of systolic function.


Eligibility criteria:
inclusion criteria: 1. female. 2. greater than age 18 years at the time of peripartum cardiomyopathy diagnosis. 3. adults with a current or prior diagnosis of peripartum cardiomyopathy and documented recovered of left ventricular systolic function. 4. documented recovered of lv systolic performance defined as lvef \> 50%. exclusion criteria: 1. no pregnancy history. 2. no diagnosis of peripartum cardiomyopathy. 3. non-recovery of lv systolic function.
study of desvenlafaxine in treating major depressive disorder.

Conditions: Major Depressive Disorder

Summary: the primary purpose of this study is to evaluate if the effectiveness of desvenlafaxine succinate sustained-release tablet (50 mg/day) used for 8 weeks is not inferior to duloxetine hydrochloride enteric-coated capsule (60 mg/day) in adult patients with major depressive disorder.

this is a multicenter study to evaluate if the effectiveness of desvenlafaxine succinate sustained-release tablet (50 mg/day) used for 8 weeks is not inferior to duloxetine hydrochloride enteric-coated capsule (60 mg/day) in adult patients with major depressive disorder. a total of 400 subjects will be randomly allocated to experimental arm (desvenlafaxine succinate sustained-release tablet) and active comparator arm (duloxetine hydrochloride enteric-coated capsule) in a 1:1 ratio.

Eligibility criteria:
inclusion criteria: * 18 ≤ age ≤ 65 years old, male or female; * outpatients and inpatients who met the diagnostic and statistical manual of mental disorders, fourth edition, text revision (dsm-iv-tr) criteria and neuropsychiatric interview5.0.0 (mini5.0.0) for a primary diagnosis of major depressive disorder(mdd), single or recurrent episode and measured by the mini-international neuropsychiatric interview5.0.0 (mini5.0.0) as active stage. * hamilton psychiatric rating scale for depression (ham-d17) total score of \>= 18. exclusion criteria: * hamilton rating scale for anxiety (ham-a) total score of \> 14. * refractory depression: ineffective after adequate treatment with two or more antidepressants. * current or previous diagnosis of axis i with dsm-iv other than depression. * significant risk of suicide based on clinical judgment or ham-d 17, suicide attempt in the past 6 months. * any unstable hepatic, renal, pulmonary, cardiovascular (including uncontrolled hypertension), ophthalmologic, neurologic, or any other medical condition that might confound the study or put the subject at greater risk during study participation.

Keywords: major depressive disorder desvenlafaxine
3d radiographic evaluation of a novel implant site development technique

Conditions: Tooth Extraction Status Nos; Edentulous Alveolar Ridge

Summary: the present retrospective study aims at assessing the clinical effects of a novel implant site development (extraction site development - xsd) technique after tooth extraction compared with extraction alone in patients requiring dental implant placement following healing of extraction sockets.

in advanced (extraction defect sounding class 3-4) alveolar defects, a minimally invasive tunnelised socket preservation technique utilising long term resorbable membranes and connective tissue grafting was used for extraction site development (xsd). the novel technique was evaluated in a retrospective comparative case series study including a total of 54 extraction sites. in the test group, out of 33 single rooted teeth, 29 in the maxilla and 4 in the mandible were removed, extractions sites were treated by the xsd method. out of 33 teeth, 27 were incisors, 2 canines and 4 premolars. in the control group, out of 21 single rooted teeth, 11 in the maxilla and 10 in the mandible were extracted and left for spontaneous healing. out of 21 teeth, 13 were incisors, 2 canines and 6 premolars. cbct scans were taken prior to tooth extraction and 6-9 months later in both groups. radiographic evaluation was carried out using the i-cat vision (imaging sciences international, llc; hatfield, usa) and imagej (national institutes of health) softwares. following manual alignment of cbcts vertical and horizontal linear measurements as well as planimetric measurements of cross-section areas were performed in pre- and postoperative data sets at the extraction sites.

Eligibility criteria:
inclusion criteria: presence of at least 1 single rooted tooth scheduled for extraction with eds class 3-4 type buccal bony dehiscence exclusion criteria: exclusion criteria int he test group included uncontrolled inflammation at the surgical site, full mouth plaque or bleeding scores more than 20%, diabetes, pregnancy, known metabolic bone diseases, smoking more than 10 cigarettes a day, history of any relevant systemic diseases, radiotherapy chronic use of bisphosphonates or systemic steroids.

Keywords: socket preservation, implant site development