Kornimate/medical-research-clean huggingface dataset:
factors associated with falling in parkinson's disease

Conditions: Parkinson Disease

Summary: the objective of this study will be to identify multidisciplinary fall risk factors in persons with stage 3 idiopathic parkinson's disease compared to age and sex-matched healthy adults. both the relative contribution of each independent factor, as well as the interaction between these factors, will be examined. the study will include multidisciplinary assessments, including locomotor, speech, auditory, vestibular and opthalmologic assessments.


Eligibility criteria:
parkinson's disease group inclusion criteria: * persons with idiopathic pd diagnosed by a medical doctor according to the united kingdom pd brain bank criteria * aged between 18 and 75 years-old * stage 3 on the hoehn and yahr scale in the on-medication state * on a stable dose of pd medication (at least one week) * able to stand and walk on a treadmill without support for at least 3 minutes * able to give consent exclusion criteria: * atypical parkinsonism * unpredictable symptom fluctuations * previous surgical management of pd (i.e., deep brain stimulation surgery; pallidotomy) * duodopa pump therapy * dementia (montreal cognitive assessment (moca) \< 21)\[1\] * symptomatic orthostatic hypotension (e.g. frequent syncope episodes) * concurrent neurological disorders (e.g. stroke) * comorbidities that affect gait or balance (e.g. peripheral neuropathy) * acute illness * epilepsy or history of seizures * depression (mds-updrs item 1.3 ≥ 2) * body weight over 120 kilograms * pregnancy * participation in other ongoing experimental trials healthy control group inclusion criteria: * age and sex-matched healthy adults exclusion criteria: * symptomatic orthostatic hypotension (e.g. frequent syncope episodes) * body weight over 120 kilograms * pregnancy * participation in other ongoing experimental trials

Keywords: parkinson's disease accidental falls risk factor gait speech audiology
effect of eti performance on cpr outcomes

Conditions: Cardiopulmonary Arrest

Summary: this is a clinical observation study based on analysis of video-clip data of cardiopulmonary resuscitation (cpr) for out-of hospital cardiac arrest (ohca) in emergency department. aim of study is to evaluate effect of the factors relating endotracheal intubation (eti) on the outcome of ohca patients.

eti is a standard method for placement of advanced airway during cpr. frequent attempts or delayed eti may affect adversely on the outcomes of ohca. however, there was no known detailed data of explaining this issues. this study tried to evaluate effect of factors of eti including numbers of trial, time for eti trial, interruption time and esophageal intubation during cpr on outcomes of ohca patients.

Eligibility criteria:
inclusion criteria: * patients who suffered sudden cardiac arrest and intubated during cpr exclusion criteria: * case of requesting the do-not-atempt resuscitation * patients who were diagnosed as adavanced cancer * cardiac arrest by multiple trauma

Keywords: intubation cardiopulmonary arrest
inhaled iloprost in mild asthma

Conditions: Asthma

Summary: the purpose of the study is to determine if inhaled iloprost given four times daily can improve symptoms and lung function in adults with mild asthma.

animal studies have suggested that prostacyclin may downregulate allergic inflammation, thus providing the scientific basis for trials of inhaled prostacyclin agonists such as iloprost for the treatment of asthma. this study will examine the tolerability of four times daily iloprost on asthma symptoms and pulmonary function over a two week treatment period.

Eligibility criteria:
inclusion criteria: 1. age 18-60 2. history of asthma controlled by inhaled rescue medication (albuterol, levalbuterol etc) and/or inhaled corticosteroids 3. ability to give informed consent 4. ability to perform pulmonary function tests 5. ability to tolerate the initial ventavis inhalation 6. ability to comply with the study protocol exclusion criteria: 1. cigarette smoking 2. concomitant serious disease such as diabetes, hypertension, coronary heart disease, other lung disease, cancer (other than skin cancer) 3. pregnancy or lack of contraception (hormonal or barrier) 4. allergies or intolerance to inhaled iloprost 5. participation in other ongoing research studies 6. any psychological problem that the investigators believe might interfere with the conduct of the investigation. 7. cigarette smoking 8. history of bleeding disorder, use of anticoagulants 9. viral upper respiratory tract infection within the last 6 weeks 10. table of upper limit for steroid use beclomethasone dipropionate hfa-mdi 480 budesonide dpi 1200 flunisolide hfa-mdi 640 fluticasone hfa-mdi 440 fluticasone dpi 500 mometasone dpi 440 triamcinolone 1500 (table adapted from epr3, daily doses are in micrograms) asthmatics requiring higher doses of inhaled corticosteroids than those given above, or using oral steroids, leukotriene modifiers, mast cell stabilizers, omalizumab, theophylline or long acting beta agonists will be excluded. 11. .any screening laboratory blood test value outside the normal range will exclude the individual from the study, though an isolated abnormal value could be retested at an interval of no less than a week.

Keywords: asthma
electromyography evaluation of the impacts of different insoles in the activity patterns of the lower limb muscles

Conditions: Electromyography; Muscles; Foot Orthoses

Summary: the main objective of this research is to demonstrate that the use of insoles of different hardness in motorcycle riders may cause variations in the electromyographic activity of the lower limb muscles during the race. this study is a cross-over quasi-experimental study. nine motorcycle riders were recruited. electromyographic activity of the lower limb muscles is recorded under different insole types.


Eligibility criteria:
inclusion criteria: * healthy subjects * motorcycle riders exclusion criteria: * musculoskeletal conditions * neurological alterations * systemic diseases.
study evaluating the nasopharyngeal carriage in healthy children

Conditions: Healthy Subjects

Summary: the purpose of this study is to assess the prevalence of pneumococcal stereotypes in the nasopharynx of healthy children and to describe the changes of nasopharyngeal carriage at different ages over time.


Eligibility criteria:
inclusion criteria: main inclusion criteria: * age at enrolment 3 to 4 month main exclusion criteria: * malformation or injury of the nasopharynx * known or suspected immunodeficiency * relevant immunosuppression * use of antibiotics up to 10 days prior to study inclusion

Keywords: s.pneumoniae healthy subjects healthy subjects
prospective analysis of effect of collagen wrap conduit on radial and ulnar nerve function following radial/ulnar forearm free flap harvest

Conditions: Head and Neck Neoplasms; Dysesthesia

Summary: the purpose of this study is to determine whether collagen nerve conduits placed on exposed radial and ulnar nerves during radial and ulnar forearm free flap harvests will reduce the occurrence and degree of sensory nerve deficit.


Eligibility criteria:
inclusion criteria: * patients present with a complex defect after tumor resection * all these cases done with the departments of oral and maxillofacial surgery and otolaryngology at the university of texas in multiple locations that include, memorial hermann hospital, ben taub general hospital, lyndon b. johnson general hospital and the methodist hospital. * patients that have been diagnosed with head and neck tumors and who will undergo a composite resection and reconstruction with radial or ulnar free vascularized flap. exclusion criteria: * pre-existing nerve deficits * pregnant women
a comparative study of different hypothermic circulatory arrest strategies on aortic surgery.

Conditions: Morality; Hypothermic Circulatory Arrest Time; Aortic-cross Clamping Time; Cardiopulmonary Bypass Time; Operation Time; Re-Thoracotomy; ICU Stay; Mechanical Ventilation Time; Blood Transfusion; Neurological Disorder; Dialysis; Aneurysm; Endoleak; Hospital Stay

Summary: by comparing the clinical outcome of patients underwent different hypothermic circulatory arrest (mild hypothermic versus moderate hypothermic) during aortic arch surgery, this study aims to determine the optimal hypothermic circulatory arrest strategy for aortic surgery.

hypothermic circulatory arrest (hca) is the cornerstone of aortic surgery. it provides a bloodless and still operative field. but the side effect of hypothermia also draws people's concern. with the development of surgical techniques and cardiopulmonary bypass (cpb) management, the temperature of hca has been raised from deep hypothermia (14.1-20 degree) to moderate hypothermia (20.1-28 degree), and it has been a primary choice for many surgeons around the world. some of surgeons still tried to push the limit and started using mild hypothermia (28.1-34 degree), and satisfactory outcome was obtained. however, the optimal temperature of hca has not yet been determined. in this randomized controlled study, 80 informed and consenting patients who are scheduled for total arch replacement with concomitant proximal aortic reconstruction will be randomized to mild (28.1-34 degree) or moderate (20.1-28 degree) hypothermia during circulatory arrest. clinical outcomes of both groups will be analyzed to determine the optimal temperature for hca.

Eligibility criteria:
inclusion criteria: 1.patients with confirmed diagnosis (i.e.aortic dissection, marfan syndrome, aortic arch aneurysm and so on), which require total aortic arch replacement. exclusion criteria: 1. preoperative heart attack or coma. 2. patients with surgical contraindication, including but not limited to severe cardiac,pulmonary,renal or hepatic insufficiency. 3. pre-existing heart condition or neurological disease. 4. variation of aortic arch or its branch vessels. 5. patient is currently on anticoagulation therapy or has other medical condition that compromises the coagulation. 6. patient with active infection. 7. allergy to anaesthetic or contrast agent. 8. pregnant or lactating female. 9. patient is already on other medical trial. 10. other medical, psychological or socioeconomics condition determined by investigator that is not eligible for the study.

Keywords: hyperthermic circulatory arrest; surgery
eswatini ring study: increasing prep options for women

Conditions: HIV Prevention

Summary: the study will deliver prep choice between oral prep and the prep ring for women in pepfar/usaid public health service delivery sites, building on the existing prep service delivery models at each site and in accordance with national guidelines for prep service delivery in eswatini. the overall goal of the study is to characterize and assess the feasibility, acceptability, uptake, patterns of use, and clinical outcomes of an enhanced service delivery package providing fully informed choice of oral prep and the prep ring among women, especially adolescent girls and young women, in eswatini.

the study will deliver prep choice between oral prep and the prep ring for women in pepfar/usaid public health service delivery sites, building on the existing prep service delivery models at each site and in accordance with national guidelines for prep service delivery in eswatini. the overall goal of the study is to characterize and assess the feasibility, acceptability, uptake, patterns of use, and clinical outcomes of an enhanced service delivery package providing fully informed choice of oral prep and the prep ring among women, especially adolescent girls and young women, in eswatini. the two main study components include the following: 1. prospective, observational cohort of eligible individuals interested in initiating prep or continuing prep with screening for entry at time of hiv testing and followed throughout the study period (up to 18 months). data collection will involve quantitative methods and for a subset of participants, data will also be collected using qualitative means, namely in-depth interviews, and focus group discussions. 2. mixed methods process evaluation that will document implementation of the enhanced service delivery package, assess ongoing perceptions of service delivery (i.e., acceptability and feasibility, barriers and facilitators) among providers and end users, and document other important implementation considerations including the integration of prep and family planning.

Eligibility criteria:
inclusion criteria: * hiv negative, 18 or older, not known to be pregnant or breastfeeding, and female at birth.

Keywords: hiv prevention prep agyw prep ring eswatini
multi-center study of new medications to treat vaginal infections

Conditions: Vaginal Infection

Summary: the purpose of this study is to evaluate the safety and efficacy of metronidazole gel in the treatment of vaginal infections.


Eligibility criteria:
inclusion criteria: * a clinical diagnosis of vaginal infection that is confirmed by laboratory testing and: * capable of providing written informed consent or assent * currently not menstruating and not anticipating menses during treatment * if heterosexually active, subject must be post-menopausal for ≥ 1 year, surgically sterile, or practicing an acceptable form of birth control * negative pregnancy test * other criteria as identified in the protocol exclusion criteria: * other infectious causes of vulvovaginitis * subject has recently used, or is expected to require the concomitant use of prohibited medications/products * nursing mother * use of any investigational drug within 30 days of enrollment * history of hypersensitivity to any ingredient/component of the formulations * other criteria as identified in the protocol
airway dimension study in children undergoing mri sedated with propofol and dexmedetomidine

Conditions: Airway Remodeling

Summary: sedation is required in infants and children to successfully complete mri while maintaining respiratory and hemodynamic stability. limited access to the patient may pose a safety risk during mri examination. therefore, appropriate drugs need to be selected, administered, and titrated to achieve these objectives. propofol is commonly used for sedation in children in the mri setting because of its predictability, rapid onset, and offset of action. dexmedetomidine has sedative and analgesic properties without affecting cardiovascular and respiratory stability. the rationale of this research is to assess the effect of these drugs on the upper airway and validate their use in children with upper airway disorders.

objectives the objective of this study is to compare the changes in upper airway configuration at the level of soft palate, base of tongue and tip of the epiglottis in children sedated with dexmedetomidine and propofol in children undergoing mri. we hypothesize that the upper airway caliber will be smaller in children receiving propofol than with dexmedetomidine. primary outcome to measure the cross-sectional area (csa) of the upper airway at the level of soft palate, base of the tongue and epiglottis in both groups of children at high doses of propofol and dexmedetomidine and thus compare the decrease in csa with increasing doses of both drugs. secondary outcomes to measure the * anteroposterior (ap) diameter * transverse (tr) diameter of the upper airway at the three levels in both groups of children at both low and high doses of propofol and dexmedetomidine and compare the decrease in ap and tr diameter at increasing doses of dexmedetomidine.

Eligibility criteria:
inclusion criteria: * children undergoing mri brain * age 2 - 5 yrs * asa i - ii exclusion criteria: * osa * pathology of upper airway * craniofacial anomalies * gastroesophageal reflux * increased intracranial pressure * body weight of 20% more than ideal * contraindication to the use of either drug * failure to maintain a patent airway during the study

Keywords: upper airway dimensions propofol dexmedetomidine
av node isolation in atrial fibrillation vs. modulation by "pace and ablate" strategy

Conditions: Atrial Fibrillation; AV Node Ablation; Escape; Rhythm

Summary: av-node ablation (avna) is a common therapy option for rate control strategy of permanent atrial fibrillation with numerous side effects. the investigators hypothesised that an isolation of the av node is concomitant with less occurrence of new bundle brunch blocks, more frequent preservation and higher rate of escape rhythm compared to avna. this retrospective study includes 20 patients being treated with av-node isolation (avni) and 40 historical avna-controls. among others these two methods were compared regarding escape rhythm, delta qrs, procedure time, ablation points, fluoroscopy time and total dose area product (dap).


Eligibility criteria:
inclusion criteria: * paroxysmal, persistend or permanent atrial fibrillation; indication for avna exclusion criteria: * other indications for avna than atrial fibrillation as avnrt, atrial flutter, atrial tachycardia
transforming diabetes care: pharmacist-led education and its impact on patient knowledge, self-management, and health outcomes

Conditions: Diabetes Mellitus

Summary: this interventional study is to evaluate the impact of pharmacist-led education on diabetic patients' knowledge, self-management, and overall health outcomes. participants in this study will attend pharmacist-led educational sessions designed to improve their understanding of diabetes and self-care practices. researchers will assess changes in patients' knowledge, self-management behaviors, and clinical health markers before and after the intervention. the study will compare pre- and post-intervention results to determine the effectiveness of pharmacist-led education in transforming diabetes care.

the purpose of this study is to investigate whether pharmacist-led education can enhance the knowledge, self-management behaviors, and health outcomes of diabetic patients. effective diabetes management requires a comprehensive understanding of the disease, adherence to lifestyle modifications, and consistent monitoring of health indicators. poor knowledge and suboptimal self-care can lead to inadequate glycemic control, complications, and reduced quality of life. this study will evaluate the impact of pharmacist-led educational interventions on patients' motivation, diabetes-related knowledge, and self-care behaviors, as well as their effects on clinical outcomes, including improved hba1c levels, reduced hypo- and hyperglycemic episodes, and enhanced patient satisfaction. by addressing these critical aspects, the study aims to highlight the transformative role of pharmacist-led education in advancing diabetes care and fostering sustainable, patient-centered healthcare practices.

Eligibility criteria:
inclusion criteria: * we will include all confirmed diabetic patients who visit the sih endocrinology opd clinic during the study duration. * both male and female patients visiting the endocrinology unit of the hospital will be eligible. * patients with hba1c levels greater than 8% will be included. * both follow-up and newly diagnosed patients will be considered. * patients who sign the informed consent form will be enrolled in the study. exclusion criteria: * we will exclude patients with gestational diabetes mellitus (gdm). * patients with central obesity will not be included in the study. * type 1 diabetes mellitus (dm) patients under the age of 20 will be excluded. * patients with inadequate medical history will be excluded from participation. * patients with hba1c levels less than 8% will not be included. * patients who do not provide informed consent or express a lack of interest in the study will be excluded.

Keywords: pharmacist patient knowledge self-management health outcome hba1c
central glutathione levels in women with late life depression: a cross sectional pilot feasibility study

Conditions: Female, Late Life Depression

Summary: female participants with an episode of late-life depression (lld) and age-matched control participants with no history of mental disorder will attend a one hour magnetic resonance imaging (mri). a 3 tesla mri scanner will be used to measure levels of glutathione (gsh) in the brain via magnetic resonance spectroscopy (1h mrs).

this is a pilot/feasibility, single-centre, open-label, cross-sectional study. research participants will be women aged 60 to 85. this study seeks to recruit 26 female participants; 13 participants with a confirmed diagnosis of late-life depression and 13 control participants with no history of mental illness. this pilot study will be used to determine if a larger randomized controlled trial is feasible. the role of antioxidant capacity in late life depression (lld) has thus far been inadequately assessed, providing the investigators with a timely opportunity to spearhead such an investigation. the results of this pilot study, and subsequent large-scale studies, will allow the investigators to identify novel targets for therapeutic intervention in lld.

Eligibility criteria:
inclusion criteria: late-life depression population inclusion criteria * patients in the lld study arm will be females 60-85 years of age with a general good bill of health * patients in the lld study arm will be presenting with mild to moderate mdd. diagnosis of mdd will be confirmed through a structured clinical interview for dsm-5-tr (scid) axis i disorder. * lld patients will have a hamilton depression rating scale (17-item version) score between 8-22 * lld patients if being treated with any antidepressant agent, will be at a minimum of 4 weeks at therapeutic dosage of medication. healthy control (hc) population inclusion criteria: * hc participants will be females between 60-85 years of age and in good general health * hc participants will have no history of depression. exclusion criteria: * a primary diagnosis of any other mental health disorder (including substance dependence, post traumatic stress disorder, obsessive compulsive disorder, bipolar disorder, neurocognitive disorders, personality disorder, etc.) * high risk of suicide as elicited by clinical interview * history of head trauma * history of severe vascular disease or cerebrovascular infarcts * any history of neurological disease (including parkinson's disease or seizures) * an ongoing acute episode of systemic inflammatory disease (e.g. rheumatoid arthritis, ulcerative colitis, crohn's disease) * any contraindications to mri * additionally for healthy control participants only, a diagnosis of any mental health disorder