Kornimate/medical-research-clean huggingface dataset:
response in patients with persistent pelvic pain to motor imagery through auditory or visual input. a pilot randomized trial.

Conditions: Pelvic Pain

Summary: the goal of this clinical trial is to compare the response of explicit motor imagery interventions in patients suffering persistent pelvic pain. the main question it aims to answer is: • does the modality of application of explicit motor imagery, either through visual or auditory stimuli, influence the response in patients suffering persistent pelvic pain? participants will receive an online explicit motor imagery program either through visual inputs or auditory inputs. they will be instructed to follow the program en register their response. researchers will compare visual explicit motor imagery and auditory explicit motor imagery to see if different inputs generate different responses in patients suffering persistent pelvic pain.


Eligibility criteria:
inclusion criteria: * experience persistent pain for a minimum duration of six months. * achieve a minimum score of six points on the chronic pelvic pain questionnaire (cppq), a validated instrument designed to assess the discrimination of pain. exclusion criteria: * participants with a medically diagnosed condition that logically accounts for the presence of pain during the aforementioned six-month period

Keywords: pain pelvic pain
detection of k14 in bladder cancer with a non invasive technique

Conditions: Bladder Cancer

Summary: by an invasive technique keratin 14 has been identified as a prognostic factor in bladder cancer. this study aims to analyze whether through a non-invasive technique keratin 14 can be used as a diagnostic and prognostic marker for this cancer.


Eligibility criteria:
inclusion criteria: * bladder cancer exclusion criteria: * inability to sign the informed consent

Keywords: bladder cancer keratin 14 pronostic marker diagnostic marker noninvasive technique
impact of capturing ictal events with ultra-long-term ambulatory eeg monitoring with remote eeg monitoring system.

Conditions: Epilepsy; Seizures

Summary: the goal of this clinical trial is to test epitel's™ remote eeg monitoring system's (remi™) ability to record electroencephalography (eeg) of seizure events in an ambulatory setting for extended periods (14 - 28 days) in patients presenting with questionable seizure characterization. the main questions it aims to answer are: • can more seizure events be recorded in fourteen (14) days than can be recorded in three (3) days? • do treating clinicians find clinical value in extended fourteen (14) - twenty-eight (28) days of eeg? participants will wear a portable eeg device (remi) for fourteen (14) to twenty-eight (28) days in their home/community setting.

this is a prospective study to quantify epitel's™ remote eeg monitoring system's (remi™) ability to record electroencephalography (eeg) of seizure events in an ambulatory setting for extended periods (14 - 28 days). patients presenting with questionable seizure characterization that are scheduling a conventional at home ambulatory eeg (amb eeg) and who meet the study inclusion and exclusion criteria will be prescribed a remi system. the purpose of this study is to demonstrate that the remi system is able to record eeg data that clinicians can use to identify ictal events over extended periods, and that extended clinical eeg data is valuable in the diagnosis and treatment of seizure related symptoms.

Eligibility criteria:
inclusion criteria: * patients have a reported history of seizures (epileptic, non-epileptic, or unknown), * have a minimum reported seizure rate of one every two weeks, * are prescribed an ambulatory eeg study as part of routine care, * is male or female between the ages of 18 and 70, * can understand and sign written informed consent, or have a legal guardian provide consent, * the patient (or primary caregiver) must be competent to follow all study procedures, * the patient must be willing to use the system for a prolonged period (up to 30 days), for a minimum of 20 hours/day. exclusion criteria: * is sensitive or allergic to medical acrylics, silicones, or hydrogels, * is enrolled in another investigational drug or device trial, * is homeless or in a home without a power supply, or * cannot read, speak, or understand english (and does not have a translator).

Keywords: eeg monitoring
a pilot study: metformin therapy in heart failure patients with early diabetes or at high risk of developing diabetes (pre-diabetes)

Conditions: Diabetes; Heart Failure

Summary: the ahmanson-ucla cardiomyopathy center is conducting a clinical research study that will assess the use of the medication metformin to improve quality of life, exercise capacity, and improved outcomes in heart failure patients with pre-dm or early dm (type ii). if the patient participates in this study, the patient will receive the drug metformin for approximately 3 months. during the study the patient will undergo comprehensive testing which includes blood draws and echocardiograms. the patient will also fill out a questionnaire. the patient must be 18 years old to participate.


Eligibility criteria:
inclusion criteria: * symptomatic hf of any etiology * age ≥ 18 years * fasting blood sugar equal or greater than 100 mg/dl, or pre-dm (hba1c 5.7 - 6.4%) or early dm (hba1c ≥ 6.5%) exclusion criteria: * current metformin therapy or other anti-diabetic therapy * previous intolerance to metformin therapy * renal dysfunction (cr \>1.5 in men or \> 1.4 in women or creatinine clearance \< 60 ml/minute) * history of lactic acidosis * current or planned pregnancy or breast-feeding

Keywords: heart failure diabetes pre-diabetes early type ii diabetes metformin pharmacotherapy with metformin for prevention of dm in hf patients with pre-diabetes (pre-dm) and glycemic control in hf patients with early type ii dm
compassion fatigue in ed providers

Conditions: Compassion Fatigue

Summary: this study will assess compassion fatigue among healthcare providers in a single emergency department (ed) using the professional quality of life (proqol) scale.


Eligibility criteria:
inclusion criteria: * currently employed as a health care provider in the emergency department. all eligible individuals will be 18 years and older. exclusion criteria: * individuals that are not currently employed in the emergency department

Keywords: emergency department
combined salicylic and azaleic acid verus trichloroacetic acid 25% peel in treatment of acne

Conditions: Acne Vulgaris

Summary: acne patients were included in this randomized controlled trial. each patient received four treatment sessions two weeks apart. 20% azelaic acid combined with 20% salicylic acid were applied to the one side of the face while 25% trichloroacetic acid was applied to the other side. evaluation was done by counting number of non-inflammatory and inflammatory lesions before, after two and after four treatment sessions. the dermoscope was used in evaluating the degree of improvement of erythema.

this study included 34 patients with mild and moderate acne vulgaris. the patients were recruited from the dermatology outpatient clinic of kasr alainy hospital. this study was approved by the ethical committee of the faculty of medicine cairo university and the ethical committee of the dermatology department cairo university. after signing an informed consent, patients were subjected to history taking, clinical examination and grading of their acne by global acne grading score, photography, dermoscopic examination and chemical peeling. photography: patient was photographed from front, lateral and side view before each session and two weeks after the 4th session. all photographs were taken using a digital camera (nikon aw1, indonesia) with identical lightening and patient positions. dermoscopy: the cheek was split as four quadrants and photography of dermoscopic figures was taken before every session and two weeks after the 4th session (using dermalite dl3n gen, usa). chemical peeling: skin degreasing was performed before every session using acetone. trichloroacetic acid 25% was applied on one side of the face and azaleic acid 20% with salicylic acid 20% to the other side of the face randomly. randomization was done through a computer-generated random sequence prepared by a statistician; allocation was concealed in sequentially numbered, sealed, opaque envelopes, and kept by a nurse not involved in the study. a gauze was used to apply the peel. the gauze was soaked with the peel. the peel was applied uniformly starting from medial to lateral. the peel was left on each side for around 60 seconds. the patients were asked to wash their faces using tape water for neutralization of the peel until the burning sensation is eliminated. patients received 4 sessions 2 weeks apart. as a post procedure care, the patients were asked to apply sun screens immediately after the procedure until their next session. no other topical or systemic treatment was used during sessions. patients will receive 4 peeling sessions 2 weeks apart.

Eligibility criteria:
inclusion criteria: * any patients with active acne exclusion criteria: 1. pregnancy. 2. history of oral herpes simplex virus. 3. history of keloid formation. 4. associated autoimmune disease (e.g vitiligo, systemic lupus erythematosus). 5. history of past medications in the last six months. 6. patient unable to perform necessary postoperative care

Keywords: acne vulgaris chemical peeling dermoscopy
influence of selenium on prostate cancer related biomarkers

Conditions: Effect of Selenium on Oxidative Stress in Healthy Men

Summary: penn state milton s. hershey medical center researchers are trying to compare the effects of two different forms of selenium (selenium yeast and selenomethionine) on blood selenium levels and biomarkers of oxidative stress as primary endpoints. one in six men are at risk of getting prostate cancer in their lifetime. participants will be asked to take over-the-counter selenium yeast supplements and selenomethionine or a placebo for nine out of twelve months.

we will conduct a double-blind, randomized, placebo-controlled clinical study of selenium supplementation in the form of l-selenomethionine (sm)(200 µg/day) and selenium-enriched yeast (sy) (200 µg/day and 285 µg/day) for 9 months; the 285 µg/day sy is selected to deliver an equivalent selenium as in 200 µg/day sm to healthy men. the variability of sm in sy that will be used here is less than 3% and it accounts for 70.5% of the sm content in sy. as primary endpoints, we will determine the effects of these two forms of selenium on plasma levels of selenium and its metabolites as well as biomarkers of oxidative stress at several time points. as a secondary endpoint, the effect of these two forms of selenium on plasma psa levels will be examined.

Eligibility criteria:
inclusion criteria: * no history or evidence of diabetes * male between the ages of 20-79 * psa levels ≤ 4.0 ng/ml * not taking \>50 µg/day selenium as a dietary supplement including multi- vitamins * non-smoker * no concurrently participating or have participated in any other clinical trial within at least 30 days of registration * health male exclusion criteria: * evidence of prostate cancer * evidence of liver or kidney disease

Keywords: selenium oxidative stress prostate cancer psa glucose
predictors of hypofibrinogenemia in severe trauma

Conditions: Severe Trauma

Summary: in this retrospective and prospective study, the aim is to determine a score for predicting a fibrinogen \<1.5g/l (corresponding to european threshold of directors recommendations of fibrinogen concentrates)


Eligibility criteria:
inclusion criteria: * age \> 18 * severe trauma exclusion criteria: * age \<18

Keywords: hypofibrinogenemia prediction score severe trauma
effects of effleurage abdominal massage on pain and quality of life in primary dysmenorrhea among students in lahore

Conditions: Primary Dysmenorrhea

Summary: to find out the answer of the study question that effleurage abdominal massage has any effect on pain and quality of life in primary dysmenorrhea among university students or nota study will be conducted with an objective to evaluate the effects of effleurage abdominal massage on pain and quality of life in primary dysmenorrhea among university students

primary dysmenorrhea, the commonly occurring gynecological issue faced by young girls. it severely affects quality of female life. it leads to fatigue, psychological issues, lack of interest in selfcare and daily activities that results in absenteeism at work and educational institutes. it also badly affects academic performance and extra-curricular activities. different pharmacological and non-pharmacological interventions are being used for reducing its negative effects, such as effleurage abdominal massage intend to decrease the problems faced by students as a result of this frightening issue. here the question arises for health professionals that effleurage abdominal massage has any effect on pain and quality of life in primary dysmenorrhea among university students or not? to find out the answer of this question a study will be conducted with an objective to evaluate the effects of effleurage abdominal massage on pain and quality of life in primary dysmenorrhea among university students. this study holds considerable implications in addressing potential adverse effects associated with pharmacological analgesic agents, thereby mitigating pain, lack of interest in work and enhancing functional capacity, hence improving quality of life. moreover, it is anticipated to contribute to the reduction of healthcare costs.

Eligibility criteria:
inclusion criteria: * unmarried female university students from lahore * aged between 18-25 years * diagnosed patients by gynecologist with primary dysmenorrhea for three previous consecutive cycles. * regular menstrual cycles ranging 21-35 days lasting for 3-7 days. * having pain score of 6 or more than 6 on numeric pain rating scale exclusion criteria: * presence of any known abdominal or pelvic disease. * obstructive vaginal or uterine congenital anomalies. * presence of known or suspected secondary dysmenorrhea. * history of major abdominal or pelvic surgery in the previous three months. * history of hormonal therapy in the last six months. * history of using analgesics during menstruation. * history of having any medical disease i.e. cardiac and renal disease. * participants doing regular exercise.

Keywords: primary dysmenorrhea female university students pain quality of life
pharmacokinetic drug interactions between single and concomitant administrations of amlodipine, losartan, and hydrochlorothiazide in subjects with (pre)hypertension

Conditions: Essential Hypertension

Summary: this study is aimed to evaluate the pharmacokinetics and the drug-drug interaction among anti-hypertension drugs-amlodipine, losartan, and hydrochlorothiazide. this pilot study provides useful information to develop a new fixed dose combination drug.


Eligibility criteria:
inclusion criteria: * adult subjects 20-50 years of age * above 55kg and within ±20% ideal body weight * subjects who are in average of 130mmhg ≤ systolic blood pressure (sbp) \< 160mmhg, 80mmhg ≤ diastolic blood pressure (dbp) \< 100mmhg * female subject who confirmed non-pregnant status and agree to comply with proper contraception. * subjects who wrote informed consent exclusion criteria: * subjects who are suspected to have acute disease * subjects who have past history that may affect drug absorption, distribution, metabolism and elimination * subjects who have gastrointestinal history * subjects whose heartrate is less than 60 * subject who suspected to orthostatic hypotension * subjects who have clinically significant allergy disease * subject is currently participating or has participating in a study with an investigational compound or device within 30 days of signing informed consent * administration of prescription drug within 14 days or over the counter (otc) drug within 7 days * subjects who have past history of drug abuse and positive in drug screening test * subjects who donate whole blood within 60 days and platelet within 30days. * subjects taking st john's wort or cyp inhibitor and inducer
prospective evaluation of symptom resolution in acid versus non-acid reflux disease following anti-reflux surgery

Conditions: Non-acid Reflux Disease

Summary: gastroesophageal reflux disease (gerd) is a common ailment affecting a significant portion of the us population. with the advent and increased use of esophageal impedance monitoring, both acid and nonacid reflux disease can be better diagnosed and treated. patients with severe symptoms or symptoms refractory to medical management may be offered anti-reflux surgery for optimal treatment. though there are a handful of studies evaluating the efficacy of anti-reflux surgery on those patients with acid or non-acid related reflux disease, the comparison between acid and non-acid reflux disease following surgery is lacking. we propose a prospective study comparing clinical outcomes from those patients with acid versus non-acid reflux disease following anti-reflux surgery with the use of validated and disease specific quality of life surveys.


Eligibility criteria:
inclusion criteria: * patients who are offered anti-reflux surgical treatment with elevated demeester scores or with low (less than 14.7) demeester scores, but with positive impedance scores (positive symptom index associated with reflux episodes). exclusion criteria: * • previous major upper gastrointestinal surgery (includes esophagus, stomach, and duodenum) - previous cholecystectomy (gallbladder removal) is not considered a major upper gi surgery * presence of paraesophageal hernia (type ii - type iv) * presence of large hiatal hernia \>5cm * presence of peptic strictures * history of severe esophageal motility disorders such as: * achalasia * diffuse esophageal spasms * scleroderma * poorly-controlled diabetes mellitus * autonomic or peripheral neuropathy * myopathy * pregnancy (as a standard operating procedure, women of child-bearing age will undergo a urine pregnancy test the morning of surgery because anti-reflux surgery is considered an elective case, where pregnancy is a relative contraindication.) * bmi greater than 40 * undergoes collis gastroplasty during surgery * conversion to an open procedure * age less than 18 years old

Keywords: nissen fundoplication non-acid reflux disease anti-reflux surgery
non invasive assessment of liver fibrosis in fatty liver disease

Conditions: Non Alcoholic Fatty Liver Disease

Summary: the purpose of this randomized clinical trial is to evaluate the utility of noninvasive markers for the detection of advanced fibrosis in patients newly diagnosed with non-alcoholic fatty liver disease (nafld) by ultrasound. the primary objective is to determine the effectiveness of noninvasive markers for detect of advanced fibrosis in patients with diagnosis of fatty liver disease. the secondary objectives are: * to determine the increase in health care with the specialist (gastroenterologist or endocrinologist). * to determine which noninvasive evaluation strategy favors any treatment of fatty liver disease.


Eligibility criteria:
inclusion criteria: * patients with bmi ≥ 27 kg/m2 and any stage of non alcoholic fatty liver, diagnosed by ultrasound. exclusion criteria: * patients with other liver disease. * patients under treatment with tamoxifen, methotrexate, amiodarone, diltiazem or other drugs able to induce fatty liver. * patients with alcohol consumption greater than 140 gr. per week * patients who have received blood transfusion before 1990

Keywords: hepatic fibrosis steatosis noninvasive markers.
the acute effect of foam rolling on elbow joint sensorimotor function

Conditions: Proprioceptive Disorders

Summary: the purpose of this study is to investigate the acute effects of foam rolling on elbow joint sensorimotor function with healthy participants . study group will receive foam rolling exercise. control group will receive no foam rolling exercise. control group will be given a brochure including information about proprioception and foam rolling.

there is no information in literature about the effects of foam rolling on elbow joint sensorimotor function. the purpose of this study is to investigate acute effects of foam rolling with healthy participants. study group will receive foam rolling exercise actively by themselves on elbow. foam rolling exercise will be applied 10 times each for 1 minute. these exercise will be performed as 2 sets. after each set will be a resting period for 30 seconds. a total of 1 session will be performed. second evaluation will be performed after exercise at the same day. control group will receive no foam rolling exercise. they will be handed a brochure about the proprioception and its role in injury prevention and foam rolling. control group will be evaluated for the first time. afterwards, second evaluation will be performed after resting period (2 minutes) at the same day.

Eligibility criteria:
inclusion criteria: * 18 years and above healthy participants * no pain in elbow area within 6 months and at the time of measurement * to be able to complete all evaluations and applications to be carried out exclusion criteria: * having previous foam rolling and self-myofascial relaxation applications on the target area * having acne and similar skin problems, open wounds * having upper extremity injury, history of fracture or surgery * having any systemic musculoskeletal disease * having diagnosis of diabetic mellitus or peripheral neuropathy * having osteoporosis diagnosis * having any cardiovascular disease * having vertigo * being pregnant

Keywords: elbow foam rolling proprioception sensorimotor acute
extended validation of human papillomavirus assays and collection devices for hpv testing on self-samples

Conditions: Cervical Intraepithelial Neoplasia Grade 2/3; Carcinoma Cervix

Summary: the "extended valhudes" study is a clinical performance / diagnostic test accuracy study that aims to extend validation, achieved as part of the "belgian valhudes", of hpv testing using bd onclarity on samples collected using copan's devices for dry self-sampling of vaginal material and for first-void urine: floqswab® 5e089n and urisponge™.

women accessing the colposcopy centres for a colposcopy examination and fulfilling the selection criteria will be asked, after written informed consent, to self-collect a first-void urine (with urisponge™ 8e031s100 device) and a vaginal sample (with floqswab® 5e089n device), prior to undergoing colposcopy. just before colposcopic examination, a clinician will also collect a cervical sample using a cervex-brush. a colposcopy-targeted biopsy or histology following excisional treatment of a cervical precancer lesion will be undertaken if appropriate. the colposcopy and/or histological findings will be used as the gold standard. in case of normal satisfactory colposcopic findings without biopsy taking, colposcopy will provide the study outcome. virological accuracy of hpv testing using: \[a\] bd onclarity on floqswab® 5e089n vaginal self-samples, \[b\] bd onclarity on urisponge™ 8e031s100 urine specimens, will be compared to bd onclarity testing on a cervical samples collected by a clinician.

Eligibility criteria:
inclusion criteria: * women, referred to colposcopy due to abnormal pap-test result, who agree to participate in the study by signing an informed consent form exclusion criteria: * women younger than 25 or older than 64 years of age * hysterectomized women * women with known pregnancy * non-consenting women * women that are not able to understand and/or sign the informed consent.

Keywords: self-sampling hpv testing diagnostic test accuarcy cervical cancer screening cervical intraepithelial neoplasia