assessing the effectiveness of acceptance and commitment therapy for distress following psychosis

Conditions: Psychosis; Schizophrenia; Bipolar Disorder; Schizo-affective Disorder

Summary: this research investigates a new talking therapy aimed at helping people to come to terms with the experience of psychosis. the new therapy is called acceptance and commitment therapy for psychosis (pact). pact aims to help people: 1. develop a sense of "mindfulness." mindfulness allows you to be fully aware of your here-and-now experience, with an attitude of openness and curiosity. it is hoped that this will help reduce the impact of painful thoughts and feelings. 2. take effective action that is conscious and deliberate, rather than impulsive. it is hoped that this will allow people to be motivated, guided, and inspired by the things that they value in life. it is hoped that pact will help to reduce the level of distress that individuals diagnosed with psychosis have been experiencing and help them to stay well in the future.

emphasis has been placed on treating the 'positive symptoms' of psychosis (e.g. hallucinations and delusions). concordance rates with anti-psychotic medication can be low. even when positive symptoms are successfully treated, emotional distress can remain e.g. depression, anxiety and trauma. relapse occurs in up to two thirds of patients within two years of the first episode. the treatment of subsequent episodes has been shown to be progressively less efficacious. research has shown that fear of recurrence patients can experience following psychosis is predictive of relapse. randomised clinical trials have found that cognitive behaviour therapy (cbtp) is efficacious for treating residual distressing positive and negative symptoms. however, the evidence for treating emotional dysfunction (e.g. social anxiety, post-psychotic depression) is less clear. acceptance and commitment therapy (act) incorporates acceptance and mindfulness elements into a cbt framework. rather than altering the content or frequency of cognitions, act seeks to alter the individual's psychological relationship with thoughts, feelings and sensations to promote psychological flexibility. this research will be a pilot randomised control trial of act for treating distress following psychosis. this pilot study will establish (a) whether a larger scale multi-centre randomised controlled trial is warranted, (b) the acceptability of acceptance and commitment therapy (c) the expected primary and secondary outcomes for such a trial and (d) the sample size required to detect such outcomes. it is hypothesised that act plus treatment as usual will be associated with a greater reduction in levels of distress than treatment as usual only.

Eligibility criteria:
inclusion criteria: * participants will meet dsm-iv-tr (apa, 2000) criteria for a psychotic disorder determined by a diagnosis of a psychotic disorder (i.e., schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, brief psychotic disorder, psychotic disorder nos) or bipolar disorder (with psychotic features). * participants will also be aged 18-65 exclusion criteria: * participants will be excluded if there is a * diagnosis of learning disability * inability to participate in psychotherapy/research due to acute medical condition or florid psychosis (as defined by a score of 5 or over on the positive syndrome scale of the panss) * psychotic symptoms due to a general medical condition * they are receiving a systematic psychological therapy at the point of recruitment/randomization.

Keywords: psychosis distress mindfulness acceptance values