Kornimate/medical-research-clean huggingface dataset:
instrumented-manual physiotherapy versus noninstrumented

Conditions: Neck Pain

Summary: this study aimed to verify the mechanical and clinical effects of instrumented massage on myofascial trigger points of trapezius muscle in adult subjects.

background: there are several therapies currently used to treat myofascial trigger points, including conservative and invasive techniques. it has been shown that conservative techniques including therapeutic massage, stretching, transcutaneal electrical nerve stimulation, spray and stretch, cold laser treatment, and ultrasound are the most applied treatments for myofascial pain syndrome, but no single strategy has proved to be universally successful. instrumented massage has shown clinical effectiveness on shoulder pain, low back pain, and only one study (case report) on myofascial trigger points. this study aimed to verify the mechanical and clinical effects of instrumented massage on myofascial trigger points of trapezius muscle in adult subjects. methods/design: the study includes 31 volunteers with myofascial trigger points on right trapezius muscle. clinical and patient data were obtained from questionnaires, vas, algometry, sono-myoelastography and myotonometry. also, physiotherapist grip strength was measured. subjects were randomly allocated into one of two groups: instrumented massage or manual massage. the intervention consisted in a single 20 minutes session of massage on the back and neck by the same therapist, depending of the group, massage was applied manually or instrumented.

Eligibility criteria:
inclusion criteria: * • to be of legal age. * to understand correctly spanish. * to show their approval by signing the informed consent. * suffering from mechanical neck pain exclusion criteria: -
autoimmunity and immune deficiency after spinal cord injury: association with rehabilitation outcomes

Conditions: Spinal Cord Trauma

Summary: the scientinel-prolong study systematically analyzes humoral autoantibody responses and thier interaction with post-spinal cord injury (sci) immune-deficiency and infections as well as their association with the clinical course of rehabilitation. therefore, molecular and immunological tests in blood and cerebrospinal fluid specimen are combined with clinical outcomes ranging from neurological function, neuropathic pain and spasticity to walking tests and measures of independence in daily living within the first year after sci. including a control group with participants suffering from vertebral fractures without sci allows to differentiate between neurological and general injury and treatment effects.


Eligibility criteria:
inclusion criteria: * acute traumatic sci, american spinal injury association impairment scale (ais) a to d, neurologic level of injury c3 - l2 or acute vertebral fracture without sci * inclusion within 21 days post-injury * for italian centers only: sci-treatment using methylprednisolone (according to nascis). exclusion criteria: * non-traumatic sci * severe multiple trauma * serious traumatic brain injury * pre-exiting neurological diseases * malignant neoplasia, except in complete remission for 5 years * rheumatic diseases / collagenosis / vasculitis * other autoimmune diseases * pre-existing chronic infection * severe alcohol or drug addiction * pregnancy or lactation * simultaneous participation in interventional clinical trials * for centers in germany or switzerland only: sci-treatment using methylprednisolone (according to nascis).
kinesiophobia in familial mediterranean fever

Conditions: FMF

Summary: kinesiophobia is a common problem in patients with rheumatic disease and can cause physical inactivity, social isolation, disability, and poor quality of life. this study aimed to evaluate kinesiophobia and associated factors in patients with familial mediterranean fever (fmf). all patients were evaluated in terms of sociodemographic characteristics and assessed using the tampa kinesiophobia scale (tks), international physical activity questionnaire (ipaq), fatigue severity scale (fss), and hospital anxiety and depression scale (hads).

familial mediterranean fever (fmf) is a common autoinflammatory disease among certain ethnic groups living in the mediterranean basin. the reported prevalence of fmf among children in turkey is 9.3/10000. kinesiophobia is a common problem in patients with rheumatic disease and can cause physical inactivity, social isolation, disability, and poor quality of life. this study aimed to evaluate kinesiophobia and associated factors in patients with familial mediterranean fever (fmf). all patients were evaluated in terms of sociodemographic characteristics and assessed using the tampa kinesiophobia scale (tks), international physical activity questionnaire (ipaq), fatigue severity scale (fss), and hospital anxiety and depression scale (hads).

Eligibility criteria:
inclusion criteria: * being age over 18 * being volunteer exclusion criteria: * ortopedic, neurologic, cardiopulmonary diseases that prevent physical activity * psychological diagnosis and drug usage

Keywords: kinesiophobia fear-avoidance physical activity familial mediterranean fever
benzodiazepine-free cardiac anesthesia for reduction of postoperative delirium

Conditions: Delirium; Post-cardiac Surgery

Summary: b-free is a pragmatic, multicentre, cluster crossover trial evaluating whether a policy limiting the use of intra-operative benzodiazepine reduces post-operative delirium when compared with a policy of 'ad libitum' administration. the knowledge generated by this study will provide the basis for cardiac anesthesia practice guidelines.

delirium, an acute state of confusion, occurs in approximately 1 in 5 adults after open heart surgery. even though it is a temporary state, patients who experience delirium are at increased risk of serious problems that last after the delirium has resolved. these problems include decreases in thinking, mobility, self-care, and the ability to live independently in a community setting. patients who experience delirium have longer stays in hospital, are more likely to be discharged to a nursing home, and are more likely to die. benzodiazepines are a sedative and amnestic medication that may be associated with delirium. as such, benzodiazepines are rarely used for sedation in the intensive care unit after cardiac surgery. however, benzodiazepines continue to be used frequently in the operating room by anesthesiologists during open heart surgery because of their amnestic effects and limited impact on blood pressure. nevertheless, practice is divided among cardiac anesthesiologists, with some never using benzodiazepines and others using them for nearly all patients. because the best approach (routine benzodiazepines or restricted benzodiazepines) remains uncertain, we will compare the effect of a hospital policy of intraoperative medication use that includes benzodiazepines to a policy that uses alternative medications and no benzodiazepines on the incidence of delirium after open heart surgery. the findings of the study have the potential to improve the outcomes of tens of thousands of patients around the world and will provide the basis for cardiac anesthesiology practice guidelines.

Eligibility criteria:
inclusion criteria: * hospital is a major surgical center with a minimum of 250 cases of cardiac surgery per year. * equipoise by the hospital physicians regarding the use of benzodiazepines during surgery (≥ 95% of hospital cardiac anesthesia group agrees to manage adult patients (age \>18 years) as per the benzodiazepine policy in place during a given crossover period). * hospital routinely assesses patients (age \>18 years) for postoperative delirium at least once every 12 hours during the initial 72 hours after cardiac surgery as a part of routine clinical care using either the confusion assessment method-icu (cam-icu) or the intensive care delirium screening checklist (icdsc). exclusion criteria: - hospital does not meet inclusion criteria
electromagnetic stimulation as coadjuvant in the healing of diaphyseal femoral fractures

Conditions: Fracture, Closed, Comminuted, Healing

Summary: this study specifically evaluates the effects of electromagnetic stimulation for diaphyseal femur fractures using a device developed by the investigators. the hypothesis is that patients with femoral diaphysis treated with the electromagnetic stimulation have less non-union after six months than patients treated with a placebo device.

the inclusion criteria were: patients of any sex, age between 18 and 60 years, with a closed fracture in their femoral diaphysis or an open fracture secondary to a low-speed bullet; treated with open or closed reduction and intramedullary reamed blocked nail. patients were excluded if they had a pathological fracture, an open fracture from another etiology, or if they were treated after 10 days from the day of fracture. 64 patients were included. randomization took place six weeks after fracture day, allocating participants to either one of two groups: group a (electromagnetic stimulation) or group b (placebo). each group had a device exactly the same. patients used the device during one hour every day for eight weeks.

Eligibility criteria:
inclusion criteria: * patients of any sex, * age between 18 and 60 years, with a closed fracture in their femoral diaphysis or an open fracture secondary to a low-speed bullet; * treated with open or closed reduction and intramedullary reamed blocked nail. exclusion criteria: * patients were excluded if they had a pathological fracture, * an open fracture from another etiology, or if they were treated after 10 days from the day of fracture.
conduction system pacing versus biventricular resynchronization in patients with chronic heart failure

Conditions: Heart Failure; Left Bundle-Branch Block; Cardiac Resynchronization; Conduction System Pacing

Summary: the purpose of this study is to evaluate the efficacy and safety of conduction system pacing versus biventricular pacing in patients with chronic heart failure with reduced ejection fraction and left bundle branch block.


Eligibility criteria:
inclusion criteria: * male or female, age ≥18 years * established diagnosis of symptomatic heart failure (new york heart association class ii-iii) * left ventricular ejection fraction ≤35% in prior 3 months * left bundle branch block (qrs ≥130 ms) * clinical indication for cardiac resynchronization therapy * patients should be clinically stable * patients should receive background standard of care for heart failure with reduced ejection fraction, with the maximum tolerated doses of ace inhibitor or arb or arni, beta-blocker, and mineralocorticoid receptor antagonist exclusion criteria: * life expectancy \<12 months due to any disease * dementia or advanced cerebrovascular disease * nyha class iv * plan to implant an implantable cardioverter defibrillator (icd), with or without resynchronization therapy (crt-d) * enrollment in other clinical trials involving cardiac pacing * pregnancy or pre-menopausal women who do not use regular contraceptive methods * patients unable to understand and sign the consent for participation
study of nitazoxanide in the treatment of amebiasis in adults and adolescents

Conditions: Amebiasis

Summary: the purpose of this study is to determine the effect of nitazoxanide tablets in treating diarrhea caused by entamoeba histolytica in adults and adolescents.


Eligibility criteria:
inclusion criteria: * age ≥12 years. * patients with diarrhea (≥3 bowel movements/day) with one or more enteric symptoms such as bloody stools, rectal bleeding or enlarged colon. * positive stool elisa test for entamoeba histolytica within 7 days prior to enrollment. exclusion criteria: * patients with identified causes of diarrhea other than e. histolytica. * use within 2 weeks of enrollment of any drug or therapy with possible anti-protozoal activity. * females who are pregnant, suspected of being pregnant or breastfeeding. * serious systemic disorders incompatible with the study. * history of hypersensitivity to nitazoxanide. * patients in whom the possibility of receiving placebo and not being able to receive immediately an effective treatment will be incompatible with the severity of the patient's illness. * patients with amebic liver abscess. * patients known to have or suspected of having aids. * patient with immune deficiencies.

Keywords: amebiasis entamoeba histolytica
current practice pattern and effect of training in upper endoscopic biopsy

Conditions: Neoplasm

Summary: the optimal number of biopsy and the detection rate of neoplastic lesions are not established. the aim of this study is to assess the current practice pattern and effect of training in upper endoscopic biopsy.

the endoscopic examination is indicated in the diagnosis of variety of gastrointestinal diseases and screening for the neoplastic lesions. especially, in korea where the stomach cancer prevalent area, high-quality endoscopic examination is required not to overlook pathologic lesions. endoscopic biopsy is the gold standard for the confirmation of endoscopic diagnosis. it is usually decided based on the abnormal morphology of the lesions or color change of the mucosa. diagnostic accuracy is known to be improved by training or using optical techniques or chromoendoscopy. with the development of endoscopic imaging technologies such as narrow band imaging (nbi), confocal imaging or magnifying techniques, the diagnostic accuracy can be enhanced. however, inspection with conventional white light endoscopy is still the most prevalent and basic form of screening or surveillance endoscopy. thus, detecting lesions by meticulous inspection and accurate approach by targeted biopsy are important for the diagnosis of pathologic lesions. however, the optimal number of biopsy and the detection rate of neoplastic lesions are not established. this study aimed at evaluating the current practice pattern and effect of training in conventional upper endoscopic biopsy.

Eligibility criteria:
inclusion criteria: * diagnostic egd including screening endoscopy for health check-up or endoscopic examinations for the symptomatic patients to make a diagnosis. exclusion criteria: * specimens from therapeutic procedures, such as endoscopic mucosal resection (emr) or endoscopic submucosal dissection (esd)

Keywords: biopsy endoscopy neoplasms
a study of preferences of participants and oncologists for the characteristics of the treatment for renal cell carcinoma (rcc) in spain and portugal

Conditions: Renal Cell Carcinoma

Summary: the purpose of this observational study is to determine patients' and professionals' preferences for the characteristics (attributes) of the treatment for renal cell carcinoma (rcc) in spain and portugal.

this study uses a literature review, qualitative (focus groups) and quantitative methods (discrete-choice experiment, dce) to determine renal cell carcinoma (rcc) participants and oncologists' preferences. in this clinical trial, the study team will develop a survey consisting of comparisons of hypothetical treatment profiles (scenarios). scenarios are presented to participants, and each participant chooses the most preferable.

Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: oncologists from spain and portugal will be identified by the promoter and invited to participate in the study in accordance with the inclusion criteria described below. * the oncologist is currently working in a spanish or portuguese public hospital. * the oncologist has at least 2 years of experience in the management of participants with renal cell carcinoma (rcc). * the oncologist has agreed to participate in the study. participants with a diagnosis of rcc will be identified and recruited by the principal investigators of the study, taking into account the inclusion criteria described below. * the participant has been diagnosed with rcc for a minimum of 2 months before study inclusion. * the participant has received or is currently receiving pharmacological treatment for rcc; * the participant has provided the informed consent to participate in the study. * the participant must be able to read, understand and complete the survey instrument according to the judgment of the responsible physician. exclusion criteria: • not applicable

Keywords: opdivo® nivolumab preference rcc
patterns of real-world isavuconazole use - a study of patients with mucormycosis or invasive aspergillosis

Conditions: Invasive Aspergillosis; Mucormycosis

Summary: this is a non-interventional medical chart review study aiming to examine the effectiveness, safety, and treatment patterns of isavuconazole in 5 european countries (france, germany, italy, spain, and united kingdom). eligible patients are adults who have been treated with isavuconazole in routine practice at participating sites since 15 october, 2015 or since the date of launch in the country if it is after 15 october, 2015 until 30 june, 2019. as this is an observational study, patients will be treated based on the standard of care at the discretion of their physician. no drugs will be supplied for this study and patients will receive treatment through standard local practice.

this observational study will include approximately 600 patients diagnosed with invasive aspergillosis or mucormycosis who received treatment with at least one dose of isavuconazole in the hospital setting. patients will be recruited in approximately 20 sites across 5 countries in europe. patients will be followed from isavuconazole initiation (index event) until six-months post-index treatment discontinuation, death, loss to follow-up, or 31 december, 2019, whichever occurs first. de-identified data on patient demographics, disease characteristics, treatment effectiveness, safety outcomes, isavuconazole treatment patterns, and hcru will be collected from patient medical records and entered into an electronic data capture (edc) system by site staff. follow-up data will include details of treatment over time and clinical, radiological, mycological, and healthcare resource utilization outcomes. as this study is retrospective, information pertaining to patient care will already be documented in patient medical records at the time of chart abstraction.

Eligibility criteria:
inclusion criteria: 1. hospitalized patient must be aged ≥ 18 years at the time of isavuconazole initiation 2. patient must have a record of a diagnosis of invasive aspergillosis or mucormycosis in their medical record at the time isavuconazole was initiated (regardless of whether this diagnosis is suspected or confirmed ) 3. patient must have received at least one dose of isavuconazole during the eligibility period (october 15, 2015, to june 30, 2019) exclusion criteria: 1. patients who did not receive at least one dose of isavuconazole for treatment of invasive aspergillosis or mucormycosis within the eligibility period
the effect of calisthenic exercises

Conditions: Physical Inactivity; Sleep Hygiene; Smartphone Addiction; Pain

Summary: this study will investigate the effects of physical activity in young adults. with the increase in physical activity, the change in smartphone addiction, pain and sleep quality parameters will be evaluated.

this study aims to increase physical activity with a calisthenic exercise program. an answer will be sought to the question of whether increased physical activity causes changes in phone addiction, pain and sleep quality parameters.

Eligibility criteria:
inclusion criteria: * volunteering to participate in the study. * being between the ages of 15-35. exclusion criteria: * individuals with an orthopedic and/or neurological disease that will affect their sleep health and/or pain level, * individuals with physical disabilities, * individuals who have undergone any surgical procedure in the last 6 months.

Keywords: physical inactivity sleep hygiene smartphone addiction pain
effects of pentoxifylline after cardiac surgery

Conditions: Oxidative Stress; AKI; Inflammation

Summary: acute kidney injury (aki) is a common and serious post operative complication and may occur in up to 50% of all patients undergoing cardiac surgery and is associated with 8% mortality rate compared with 0.9% in non-affected patients and remains a major factor for post surgery adverse outcomes. early interventions to prevent postoperative aki can help decreasing morbidity and mortality in these patients. using cardiopulmonary bypass during cardiac surgery triggers systemic inflammatory response and recruits pro-inflammatory cytokines such as tumor necrosis factor, interleukin -10 (il-10) and interleukin-6 (il-6) accompanying with production of free oxygen radicals which provokes oxidative stress in the milieu of ischemic reperfusion injury. pentoxifylline as a non-specific phosphodiesterase inhibitor, can suppress the production of some factors of inflammatory response and oxidative stress, probably prevent post surgery aki with these mechanisms.

this is a double blind randomized multicenter clinical trial, enrolling 100 consecutive patients undergoing elective coronary artery bypass graft surgery (cabg). patients randomly and within concealment method divided into two groups, one to receive oral pentoxifylline 400 mg every 8 hours from three days before surgery and the other group received placebo. all the intubation , surgery and weaning protocols were the same.

Eligibility criteria:
inclusion criteria: * the elective cabg candidate exclusion criteria: * refusal to sign the consent, * collagen vascular disease, * use of immunosuppressive agents, corticosteroids (\> 3 days), methylxanthines, diltiazem or sodium nitroprusside, * angiography in the past 7 days, * hemorrhagic diathesis and coagulopathy, * uncontrolled diabetes mellitus * sepsis * renal failure (scr \> 2 mg/dl), * hepatic failure (ast (aspartate transaminase) or alt(alanine transaminase) \> 40 u/l) * urinary tract infection.