Kornimate/medical-research-clean huggingface dataset:
screening, treatment, and eradication of hep c

Conditions: Hepatitis C Virus Infection

Summary: the aim of this study is to assess the hcv screening rate in arizona by identification of potential hcv patients/subjects through different methods of communication - text message, email, social media, radio, newspaper ads, and flyers.

the study will focus on various methods of communication to reach the population of arizona from the most prevalent counties to lowest prevalence. the study is organized into phases focusing on the various communication methods beginning with direct communication through mass text messages and mass emails followed by indirect communication through social media (youtube, facebook), newspaper, radio, alcoholics anonymous meetings, narcotics anonymous meetings, and homeless shelters. each phase will consist of four cycles of a monthly intervention period in which communication will be active and a two-month gap that will be used to assess effectiveness of the communication method. subjects will receive information on hcv, contact information for the study coordinator at the liver institute pllc to address questions or concerns, and a code that will allow them to receive a free hcv screening test at their local sonora quest lab. this code can be used at the time of receipt or a few months later, whenever the subject is ready for testing. this timeline allows to enhance subject compliance. the results from sonora quest lab will be transmitted to the study coordinator at the liver institute pllc and depending on the subject's insurance status will link the subject to a treatment center. ideally it will be their primary care physician but if the subject does not have one then it will be the closest treatment center. alternatively, the liver institute pllc is also equipped to provide telemedicine appointments to evaluate the subject and provide treatment depending on insurance status. those that are uninsured will be provided with available options for treatment. all subjects will receive information on the disease to reduce transmission and encourage friends/family to get tested. this study will function on a version of the test-and-treat approach to help reduce the spread of hcv in the arizona population.

Eligibility criteria:
inclusion criteria: * subjects must sign the consent to screen and take part in the study. * subjects must be at least 15 years of age exclusion criteria: * patients will only be enrolled once * patients who do not meet the inclusion criteria * patients with a current hcv diagnosis * patients who underwent a liver transplant

Keywords: liver hepatitis c virus screening disease eradication
study on the effect of capacity shock intervention under goal-directed hemodynamic management on p-v loop

Conditions: Hemodynamics

Summary: by observing the changes of p-v loop in capacity shock intervention under goal-directed hemodynamic management in patients undergoing total knee replacement, we investigate the effect of capacity shock on cardiac contractility and work in order to seek a more effective target plan of capacity shock for intraoperative patients.

objective:by observing the changes of p-v loop in capacity shock intervention under goal-directed hemodynamic management in patients undergoing total knee replacement, we investigate the effect of capacity shock on cardiac contractility and work in order to seek a more effective target plan of capacity shock for intraoperative patients. methods:20 patients with total knee replacement were enrolled in this study. capacity shock therapy was used in group a(n=10) and conventional strategy was used in group b (n=10). v(t) was measured and calculated using tee and p(t) was acquired by the analysis of patients'radial artery pressure waveform. we set five time points of parameter acquisition: after grouping (t1), the first shock completion(t2), the second shock completion (t3), 1h after shock treatment (t4), and operation completion(t5). we make up the p-v loop fitting p(t) and v(t) at each time point after the calibration of cardiac cycle.

Eligibility criteria:
inclusion criteria: asai-ii age 40- 70 weight 48 - 72 kg. exclusion criteria: body mass index \>30 or \<15 kg/m2 valve heart disease left ventricular ejection fraction (lvef) is less than 50% history of lung disease preoperative arrhythmic disorder permanent pacemaker need for mechanical heart support, severe extrinsic vascular disease valve dysfunction oed monitoring probe insertion contraindications patients with preoperative assessments
erector spinae plane block for minimally invasive mitral valve surgery

Conditions: Mitral Regurgitation; Mitral Valve Insufficiency; Mitral Valve Prolapse

Summary: the goal of this project is to study whether local anesthetic via the erector spinae plane (esp) block may be beneficial in minimally invasive mitral valve surgery (mimvs).

this is a double blinded randomized controlled trial comparing a control group receiving cryoablation and sham block with an intervention group receiving cryoablation and esp catheter. the primary outcome is total oral morphine equivalent (ome) consumption within the first 48 hours of recovery including intra-operative usage. secondary outcomes to be evaluated would include pain scores, functional milestones like time to extubation, time to first po intake, time to ambulation, time to chest tube removal, length of icu and total hospital stay, complications, and patient satisfaction.

Eligibility criteria:
inclusion criteria: * elective mitral valve repair or replacement * planned minimally invasive approach exclusion criteria: * non-english speaking * emergency surgery * planned or unplanned sternotomy * previous history of sternotomy and cardiac surgery * allergy to ropivacaine * patients taking more than 60 omes per day * patients with coagulopathy or taking anticoagulant with laboratory findings contraindicated for esp catheter

Keywords: mitral valve replacement mitral valve repair mitral valve surgery erector spinae plane minimally invasive surgery
extended and controlled release liposomal formulated dexamethasone for chronic knee oa pain

Conditions: Osteoarthritis of the Knee

Summary: phase 3 randomized, double-blind, placebo- and active comparator-controlled study of tlc599.

this is a phase 3 randomized, double-blind, placebo- and active comparator-controlled pivotal study. approximately 500 adult patients with moderate to severe pain due to oa of the knee will be enrolled and randomized. all patients will be followed for a total of 52 weeks. efficacy and safety of 2 doses of tlc599 will be evaluated in comparison to placebo and dsp through week 52.

Eligibility criteria:
inclusion criteria: male or female ≥40 years of age. bmi ≤ 40 kg/m2. radiographically documented oa with kellgren-lawrence severity grade 2 or 3 and associated symptoms patient-reported pain with nrs score ≥4 (on a 0-10 scale) able to read, understand, and sign the informed consent form, communicate with the investigator, complete study diaries, and understand and comply with protocol requirements. exclusion criteria: recent use of ia or systemic corticosteroids patient who is not ambulatory any surgery or arthroscopy in the index knee within 12 months any condition that could possibly confound the patient's assessment of index knee pain substance abuse disorder, or positive urine drug test for illegal drug substances history of acquired or congenital immunodeficiency diseases history of treated malignancy which is disease free for ≤5 years known allergy or hypersensitivity to the study drugs or their components
mipo versus conventional approach in volar locking plate for close fractures distal end radius under walant

Conditions: Radius; Fracture, Lower or Distal End

Summary: the goal of this clinical trial is to compare the minimally invasive plate osteosynthesis (mipo) approach with conventional methods in volar locking plate treatment for distal end radius fractures under the wide awake local anesthesia no tourniquet (walant) technique. the main question it aims to answer is: does the mipo approach provide better pain control than the conventional approach of volar locking plate fixation in distal radius fractures under walant? participants will be requested to record their pain on the visual analog scale (vas), assess their functional scores, and undergo postoperative radiographic evaluations. researchers will compare the mipo group and the conventional group to determine the postoperative pain vas scores, shedding light on the comparative effectiveness of the two approaches.

gap of knowledge * no comparison of conventional versus mipo technique under walant * no result in acute post-operative pain

Eligibility criteria:
inclusion criteria: * isolated closed fractures of the distal end radius requiring surgery * aged 18 years and older exclusion criteria: * patients with bone fractures lasting more than 21 days * open fractures * articular multi-fragmentary comminuted fractures of the distal radius * not suitable to undergo volar approach surgery * individuals with combined carpal fractures or dislocation * ulna fractures * associated injuries * a history of previous wrist surgery * diabetes mellitus * chronic wrist inflammation * wrist bone deformities * the use of anticoagulation drugs * uncooperative behavior * those refusing to participate in the research

Keywords: mipo distal end radius fracture walant
the coagulation cascade in idiopathic pulmonary fibrosis

Conditions: Idiopathic Pulmonary Fibrosis; IPF; Interstitial Lung Disease

Summary: the pathogenesis of idiopathic pulmonary fibrosis (ipf) is incompletely understood but recurrent epithelial injury occurs which evokes the coagulation cascade. thrombin is produced as a result and is over expressed in ipf patients, so may be important in propagating disease activity. we aim to recruit patients with ipf and then complete fdg (18f-2-fluoro-2-deoxy-d-glucose fluorodeoxyglucose) pet (positron emission tomography) scans pre and post manipulation of the coagulation cascade to assess the role of this biological pathway in disease activity. previous studies from our institution have demonstrated increased fdg avidity in the lungs of patients with ipf (assessed using fdg pet scans) but to date the cells and pathways responsible for this signal have not been identified and thus need further exploration.

patients with ipf who meet all the inclusion criteria (and none of the exclusion criteria) will be assessed and invite to participate. they will undergo baseline assessment with lung function, 6 minute walk test and health quality assessments. blood tests will assess the pro-coagulant state of these individuals. they will undergo a baseline fdg pet scan followed by manipulation of the coagulation cascade with 24 days (+/- 3 days) dabigatran. they will then complete a second fdg pet, health quality assessments and blood tests to demonstrate target engagement.

Eligibility criteria:
inclusion criteria: * a diagnosis of ipf based on multi disciplinary meeting discussion following review of the clinical history, characteristic features on hrct (high resolution ct scan) and/or usual interstitial pneumonia (uip) histology. * written informed consent obtained from subject. exclusion criteria: * age \ 80 years * renal impairment as defined by a creatinine clearance of \<30 millilitres/min * significant liver impairment with evidence of synthetic dysfunction * any contraindication to anti-coagulation including previous life threatening or serious bleed or bleeding tendency. * co-administration of any concomitant medications prohibited in full protocol. n-acetyl cysteine, prednisolone up to 10mg daily and pirfenidone are permitted. * pregnant, breast feeding or unwilling to practice birth control during participation in the study (females of child bearing age). * presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient of the quality of the data.
non-ablative radiofrequency and low intensity shock wave therapy in fibrotic plaque in men with peyronie's disease

Conditions: Peyronie Disease

Summary: the goal of this one arm clinical trial is to evaluate the safety and describe the clinical response of non-ablative radiofrequency treatment associated with shockwave therapy in men with peyronie's disease. the main question\[s\] it aims to answer are: • is the treatment safe? • is there any clinical response to the proposed treatment? participants will respond to five validated questionnaires: international index of erectile dysfunction (iief-5), medical outcomes study 36 - item short - form health survey (sf-36), peyronie's disease questionnaire (pdq), scale hospital for anxiety and depression (shad) and the erection quality questionnaire (eqq); will undergo a physical assessment that includes palpation of the fibrotic plaque on the penis, pharmacological induction of erection, and assessment of the size of the fibrotic plaque through ultrasound. every five sessions, the participant's degree of satisfaction will be measured using a 5-point likert scale, as well as the evolution of symptoms will also be observed, using a 10-point visual analogue scale (vas) and penile pain, if present. the entire evaluation protocol will be applied before (pre-test), after treatment (post-test) and 1 month after the end of treatment. volunteers will be monitored by telephone to verify the long-term response after 3, 6, 9 and 12 months of completed treatment in relation to the likert scale and vas. the treatments they'll be given are • of monopolar non-ablative radiofrequency associated with • low-intensity shock wave therapy.


Eligibility criteria:
inclusion criteria: * clinical complaint related to peyronie's disease; * at any stage of the disease (acute or chronic). exclusion criteria: * users of a pacemaker, cardiac defibrillator implant or any other electromagnetic implant; * metallic implants over or under the area to be treated.

Keywords: peyronie disease non ablative radiofrequency low-intensity shock waves therapy
social network based intervention to reduce lead exposure among native american children

Conditions: Lead Poisoning

Summary: the purpose of this study is to examine whether adding an inter-generational component to an existing social network-based lay health advisor intervention increases its effectiveness in mobilizing a native american community to respond to heavy metal contamination from lead and zinc mining.

ottawa county, oklahoma, the site of the research, was heavily mined for zinc and lead in the first half of this century. mine tailings containing heavy metals are stored in large piles up to 200 feet in height. ottawa county is home to 8 indian tribes and much of the mine waste is on tribal land. specifically, the study will: a) integrate existing native american youth programs with the existing lay health advisor intervention (society of clan mothers and fathers) to form an inter-generational intervention, b) expand the existing lay health advisor intervention to address cadmium in addition to lead, c) use participatory research methods to involve tribal youth and adults in an air monitoring study, d) assess the extent to which the intervention contributes to belief, attitude and behavior changes that will reduce heavy metal exposure and absorption in native american children; and e) assess the contribution of the intervention to creating changes in organizational, community, tribal and government (city, county, state, federal) capacity to address heavy metal contamination in ottawa county, oklahoma.

Eligibility criteria:
children ages 1-6 live in ottawa county, oklahoma

Keywords: lead poisoning native americans
role of the striatal cholinergic system in the pathophysiology of dystonia

Conditions: Dystonia

Summary: dystonia is defined as a syndrome of sustained muscle contractions resulting in repetitive movements and abnormal postures. dyt1 is the most common form of genetic dystonia, but the link between genomic mutations and phenotypic expression remains largely unknown. furthermore, secondary forms of dystonia have highlighted the role of the basal ganglia, particularly the putamen in the pathophysiology of the disease. experimental results in a genetic model of dystonia in rodents suggest that cholinergic inter-neurons (ach-i) of the putamen play a critical role in the pathological process of plasticity in the cortico-striatal synapse. however, these results have not been demonstrated in humans.

the purpose of this study is to demonstrate that the phenotype of dystonia is associated with the degree of striatal ach-i alterations. in this molecular imaging study, the investigators will directly test this hypothesis using a pet radiotracer of the vesicular acetylcholine transporter (vat). their goal is to explore the relationships between cholinergic dysfunction and clinical disease expression and the associated morphological and functional alterations. the experimental protocol will also include multimodal mri, mri diffusion tensor (to study the microscopic structure of white matter) and functional mri of the resting state (to study the functional organization of cerebral cholinergic networks at rest).

Eligibility criteria:
inclusion criteria: * man or woman 18 to 75 years, with health insurance european health insurance card (for resident patients in eu), insurance by bilateral social security agreement signed between his country and france (for resident patients outside the eu) * diagnosis of dystonia dyt1 confirmed by molecular biology (torsine- a gene mutation) * patient who stopped his anticholinergic treatment 48 hours before imaging exclusion criteria: * patients who underwent surgery for deep brain stimulation or under cholinergic treatment. * presence of a counter-indication for mri * presence of a counter-indication for tep scan with \[18f\]-feobv * woman premenopausal without effective ongoing contraception (intrauterine device or combined hormonal) * patient who underwent a pet examination in the previous month * presence of any health problem preventing travel to the imaging service of the university hospital * being under the legal guardianship of another person or being unable to provide consent to participate * pregnant or breastfeeding woman

Keywords: dystonia binding potential feobv
cbt in adolescents with type 1 diabetes

Conditions: Type 1 Diabetes Mellitus

Summary: the effectiveness of cognitive behavioural therapy (cbt) for adolescents with type 1 diabetes will be tested. this structured, time-limited, problem-orientated therapy will be used to impact on psychosocial factors influencing diabetic control, with the patient and therapist working together on specific goals to develop adaptive strategies.

ninety 11-16 year olds with t1dm (duration \>1 year), attending paediatric diabetes outpatient clinics based in 4 centres in south-west england, uk, will be recruited to a randomised controlled trial of one to one sessions of cbt versus non-directive supportive counselling. participants will attend up to 6 sessions (weekly) with either a cbt therapist or a counsellor, with 2 further sessions at 6 and 12 months. follow up will continue for 12 months post intervention. hba1c is the primary outcome measure. psychological measures will also be measured.

Eligibility criteria:
inclusion criteria: * attendance at out-patients clinics at bristol royal hospital for children, southmead hospital in bristol, weston general hospital, the royal united hospital in bath, gloucestershire royal hospital in gloucester or the musgrove park branch of the taunton and somerset hospital aged 11-16 years old (inclusive) on the first day of the study type 1 diabetes duration at least 12 months on the first day of the study exclusion criteria: * chronic illnesses with dietary management implications (e.g. cystic fibrosis and coeliac disease) special educational needs (e.g. down's syndrome) making the patient unable to co-operate with cbt in care of social services primary responsibility for care elsewhere english not spoken as a first language known psychological/ psychiatric problems for which the patient has already been referred

Keywords: type 1 diabetes mellitus adolescents cognitive behaviour therapy
effects of hericium erinaceus on microbiota and cognition

Conditions: Cognitive Decline, Mild

Summary: the study evaluates the effects of hericium erinaceus on microbiota, cognition, and other health parameters in older adults. all measurements will be performed at baseline and ten weeks after daily consumptions of either hericium erinaceus or placebo.

hericium erinaceus, a well-known edible mushroom, has numerous biological activities. yamabushitake (hericium erinaceus) is a mushroom that grows on both living and dead broadleaf trees. yamabushitake is used as food in japan and china. hericenones and erinacines stimulate nerve growth factor synthesis, and therefore it is expected that h. erinaceus have some effects on brain functions and autonomic nervous system. hericium was tested in several applications, such as dementia, alzheimer's disease, parkinson's disease, multiple sclerosis, neuropathy and neurasthenia. the ancient chinese knew about these possibilities and used it to support mental functions and memory, concentration. it is also very good for various digestive problems, such as gastritis, stomach ulcers, heartburn, reflux and improvement of digestion. therefore, the aim of our study is to evaluate the effects of hericium erinaceus on microbiota, cognition and related parameters in elderly. the stool samples will be taken at baseline and after ten weeks of daily consumption of hericium erinaceus or placebo. in addition, cognitive tests, anthropometric measurements, and blood analysis (lipid profile, glucose levels and neurotrophic factors) will be measured at the same time points.

Eligibility criteria:
inclusion criteria: * age 55 - 75 years exclusion criteria: * neurodegenerative disease * organ transplantation * allergy to fungi * antibiotic consumption in the previous 3 months