Kornimate/medical-research-clean huggingface dataset:
robot-assisted training for stroke recovery

Conditions: Stroke

Summary: the robot assisted therapy is one of the new developed technologies for recovery after stroke. this study aimed to evaluating the effect of robotic gait therapy for motor recovery after stroke.

this study designed an assessor-blinded, randomized, controlled clinical study. the participations followed the study protocol and were randomly divided into the control group and walkbot group. the control group received conventional functional rehabilitation for 40 min/session, 2 sessions/day, 5 days/week for 4 weeks, 40 sessions in all. whereas the walkbot group received conventional physical therapy (session i for 40 min/day) companied with walkbot training (session ii for 30 min/day) 5 days a week for 4 weeks, 40 session in all. after 4-week intervention all subjects received conventional physical therapy only, 40 min/day, 5 days/week for 4 weeks. during the test period, general rehabilitation and drug treatment can be done at the same time.

Eligibility criteria:
inclusion criteria: * the subjects (age\>19) with stroke 4 weeks after the onset but within 12 months were included. exclusion criteria: * participated in the clinical studies, or received the rehabilitation therapy or therapy associated with the rehabilitation for the purpose of motor function improvement within thirty days before the start of this study. * cognitive disabilities or serious psychiatric illness. * difficulty in walking due to orthopedic problems. * ejection fraction less than 30% due to severe heart disease or with a diagnosis of unstable angina. * weight more than 135 kg or height less than 150 cm. * pregnancy subjects.

Keywords: stroke robot-assisted therapy conventional therapy motor function
lacrimal deroofing for epiphora from punctal abnormalities

Conditions: Eyelid Diseases

Summary: puncto-canalicular abnormalities, such as obstruction and canaliculitis, are a significant cause of epiphora. they involve proximal lacrimal drainage system. proximal lacrimal obstructions classified into punctal stenosis canalicular obstructions. the basic principles in the treatment of punctal stenosis include creating an adequate opening, while maintaining the position of the punctum against the lacrimal lake, and preserving the lacrimal pump function. the severity of epiphora can be valued trough a grading system such as the munk scale, fluorescein dye disappearance test, and syringing and probing and contrast dacryocystography. canaliculitis is defined as infection of the proximal part of the lacrimal drainage system. this condition can be caused by primary infectious organisms or secondary to punctal plugs and lacrimal stents. diagnosing canaliculitis is frequently misdiagnosed. the management includes conservative measures, local massage, syringing, and irrigation. nevertheless, refractory cases required surgical intervention.

purpose: to report outcomes of proximal lacrimal deroofing in the management of proximal lacrimal drainage system abnormalities. inclusion criteria: at least 18 years old patients with lacrimal punctum stenosis and/or canaliculitis. exclusion criteria: trauma, thyroid eye disease, lacrimation and other causes of epiphora. evaluation: all patients underwent a comprehensive ophthalmic examination, and lacrimal drainage evaluation at baseline,2 weeks and 6 months after the surgery. outcome measures: munk scale for epiphora grading (0-5); 0 no epiphora ,1 epiphora requiring dabbing less than twice a day, 2 epiphora requiring dabbing 2-4 times a day, 3 epiphora requiring dabbing 5-10 times a day, 4 epiphora requiring dabbing more than 10 times a day, 5 constant epiphora. grading of external lacrimal puncum (0-5); score 0: no papilla and punctum (punctal atresia); surgery to create a papilla, score1: papilla is covered by a membrane; a #25 needle, followed by a punctal finder. exudative or true membrane or fibrosis, difficult to recognize with standard punctum dilator, score 2: less than normal size, but recognizable; a punctal finder and, then a standard punctum dilator required, score 3: normal; regular punctum dilator required, score 4: small slit (\< 2 mm); no intervention required, score 5 large slit (≥ 2 mm); no intervention required.

Eligibility criteria:
inclusion criteria: * epiphora due to lacrimal punctum stenosis and/or canaliculitis. exclusion criteria: * trauma, thyroid eye disease, lacrimation and other causes of epiphora.

Keywords: lacrimal epiphora
biomechanical precision medicine registry for patients with and without heart failure

Conditions: Heart Failure With Normal Ejection Fraction; Heart Failure With Reduced Ejection Fraction; Heart Failure, Right Sided; Heart Failure With Mid Range Ejection Fraction; Cardiovascular Risk Factor

Summary: in this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may develop and progress over time. we will evaluate distinct sub-groups of heart failure (also known as heart failure phenotypes) and cardiomyopathies including amyloidosis with an ultimate goal of bringing the right medications and therapy to the right patients to optimize benefit and minimized side effects, an effort to improve precision medicine in heart failure.

patients 18-years and older with and without heart failure (across all left ventricular ejection fraction) and cardiomyopathies including amyloidosis will be enrolled in this single center, longitudinal observational registry. baseline and one-year follow up blood samples including dna as well as clinical characteristics, events leading up to heart failure diagnosis, etiology of heart failure, the presence and duration of other medical problems, laboratory, echocardiographic data and images, and therapy information will be obtained. clinical outcomes of interest include major adverse cardiovascular events (a combination of all-cause death and heart failure hospitalizations), individual endpoints of all-cause death, cardiovascular death, all-cause hospitalization, cardiovascular hospitalization, heart failure hospitalization, right-sided heart failure, and kidney injury. results from the preserved vs. reduced ejection fraction biomarker registry and precision medicine database for ambulatory heart failure patients (prefer-hf) trial will comprehensively examine longitudinal clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand pathophysiology of heart failure and phenotypes in heart failure with an ultimate goal of improving precision medicine in heart failure.

Eligibility criteria:
inclusion criteria for patients with hf: * 18 years and older * history of clinical symptoms consistent with hf and at least one of the following supporting evidence of hf: * nt-probnp \> 125 pg/ml * bnp \> 35 pg/ml * capillary wedge pressure ≥ 15 mmhg on right heart catheterization or ci \<2.8 l/min/m2 * lvedp ≥ 15 mmhg * radiographic evidence of pulmonary edema * improvement in symptoms with diuretic initiation of increase * cpet evidence of cardiac etiology of symptoms hfpef: lvef ≥ 50% hfref: lvef \<50% exclusion criteria (for all patients, including both those with hfpef and hfref): - end stage renal disease on dialysis

Keywords: heart failure precision medicine high risk patients pathophysiology bioregistry biomarkers heart failure etiology
abdominal ice packs for pain control and reduction of narcotic use following laparoscopic hysterectomy

Conditions: Pain, Postoperative; Hysterectomy; Narcotic Use; Cryotherapy Effect

Summary: the purpose of this study is to evaluate the effect of using ice packs on the abdomen immediately after laparoscopic hysterectomy surgery on pain control and narcotic pain medication use.

hysterectomy is one of the most common surgical procedures performed on women in the united states, with approximately 600,000 performed annually. the use of postoperative cooling as an adjuvant for post-operative pain control has previously been shown to be effective and safe in a variety of procedures, but has yet to be described for laparoscopic surgery. in contrast to laparotomy where the wound is a significant pain generator and direct application of ice is intuitive, in laparoscopic surgery much of the pain-generating tissue trauma is intraperitoneal and pelvic in nature, away from the abdominal wall. ice pack use on the abdominal wall likely inhibits visceral afferent pain fibers via somatic afferent nerve cross-talk. accordingly, applying ice to the abdominal wall and its somatic afferents may improve laparoscopic pain control, despite the lack of a significant abdominal wound. our goal is to quantify narcotic use after hospital discharge following hysterectomy, and evaluate the effectiveness of abdominal ice packs as low cost adjuncts for pain control.

Eligibility criteria:
inclusion criteria: * women undergoing robotic or conventional laparoscopic hysterectomy exclusion criteria: * any opioid use within 2 weeks of surgery date * planned post-operative icu admission * conversion of laparoscopic approach to laparotomy or any incision ≥4 cm * regional anesthesia/analgesia, including tap block use

Keywords: analgesia laparoscopy pain
heart rate variability of premature newborn

Conditions: Autonomic Nervous System Imbalance

Summary: to analyze the effects of two cpap methods on the hrv of ptnbs during their routine routine in the hcufu neonatal icu. this is a randomized clinical trial, with controlled groups and cross over with healthy term newborns (rnt) as a control group admitted to the hc-ufu rooming-in and premature newborns (ptrn), between 28 and 32 weeks pregnant women with nasal cpap group admitted to the neonatal icu of the same hospital. the hrv recorded by the polar® rs800cx cardiac monitor will be analyzed, with a sampling rate of 1000 hz. the main question\[s\] it aims to answer are: * is there a difference in heart rate variability between newborns using conventional nasal cpap and nasal bubble cpap? * is it possible to conclude that one of the methods has a greater sympathetic or parasympathetic tone compared to the other? premature participants will be in the incubators in a supine position with 30 minutes rest after the last handling. each data collection will last 60 minutes and will be carried out three times a day in the morning, afternoon and night shifts, for each 1-hour collection, hrv will be analyzed in 12 5-minute intervals, establishing an average for each variable of the data. hrv during a 1-hour period. the researchers will compare the conventional cpap and bubble cpap group according to randomization. * in the control group, data collection will be carried out in the rooming room in a single reference collection lasting 20 minutes, and analyzed in 4 5-minute intervals. * the participant selected for conventional cpap will receive conventional cpap for 24 hours, then receive bubble cpap for 24 hours the following day. the opposite will be done for the participant drawn for cpap bubbles. the comparison between the conventional cpap and bubble cpap groups will occur to find out whether it is possible to identify the type of non-invasive ventilation that allows an increase in hrv and parasympathetic tone variables, as well as a reduction in sympathetic tone variables and the stress index of premature babies.


Eligibility criteria:
inclusion criteria: * all preterm infants between 28 and 32 weeks of gestation using nasal cpap and who are at least 8 and at most 12 days old will be included in the study. exclusion criteria: * hemodynamic instability, * hydroelectrolyte disorders that influence cardiac function, * post-operative, * congenital abnormalities, * pulmonary hypertension, * decompensated ductus arteriosus, * untreated atelectasis, * pneumothorax, * newborns who are using drains, whether chest or abdominal, * presence of necrotizing enterocolitis * grade 3 nasal septum injury, * signal captured without the necessary quality to be used in research, * premature babies who, for whatever reason, do not have two collections carried out on consecutive days until the twelfth day of life.

Keywords: heart rate variability neonatal intensive care unit non-invasive ventilation
effect of bioptron on scar formation after cesarean section

Conditions: Cesarean Section

Summary: the purpose of the study will be to determine the effect of polarized light therapy (bioptron) on scar formation after a cesarean section.

cesarean deliveries are among the most frequently performed surgical procedures for women worldwide, with their prevalence increasing globally, especially in developing nations like egypt. a scar is a natural outcome of the healing process following a wound. complaints associated with scars can lead to both physical discomfort and psychological challenges. enhanced healing of cs scars could lead to better postoperative outcomes, reducing complications such as infection, pain, and restricted mobility. these aspects of recovery are often neglected, as noted by. this study will be the first to specifically examine the effects of bioptron light therapy on cs scar formation. while previous research has shown the benefits of this therapy on scars from various operations, none have focused on cs scars. by investigating this innovative, non-invasive treatment approach, the study aims to fill a critical gap in existing research and offer valuable insights into managing and improving postoperative recovery for cs patients.

Eligibility criteria:
inclusion criteria: * the participants' ages will be ranged from 20-30 years old. * their body mass index (bmi) will not exceed 30 kg/m2. * they will be primipara and having abdominal scar after cs. * the scar age will be extended from 6 weeks to 6 months. * all women will be medically stable when attending the study. exclusion criteria: * pregnant women or women planning to become pregnant during the study period. * women having diabetes mellitus. * women taking immunosuppressant drugs.
intravenous triple therapy in the treatment of helicobacter pylori infection and related complications caused by active peptic ulcer disease

Conditions: Helicobacter Pylori Infection; Intravenous Drug Usage

Summary: helicobacter pylori infection causes active peptic ulcer disease and related complications like bleeding and pyloric obstruction. usually, clinicians tended to treat helicobacter pylori infection after active peptic ulcer disease and related complicaitons getting healed, which spent time and money. this study is designed to evaluate the efficacy and safety of intravenous administration of metronidazole, levofloxacin and esomeprazole triple therapy in the treatment of helicobacter pylori infection combined with peptic ulcer disease related complications.


Eligibility criteria:
inclusion criteria: * male or female aged between 18 and 75 years old * without previous helicobacter pylori treatment * diagnosed with active peptic ulcer disease and related complications like bleeding and pyloric obstruction by endoscopy examination * ability and willingness to participate in the study and to sign and give informed consent * positive for helicobacter pylori igm antibody exclusion criteria: * with previous gastric surgery * major systemic diseases * pregnancy or lactation * allergy to any of the study drugs * decline to participate in the study

Keywords: helicobacter pylori infection intravenous drug usage
study of metabolic dysfunction-associated steatotic liver disease among sohag university employees

Conditions: Metabolic Dysfunction-Associated Steatotic Liver Disease

Summary: * metabolic dysfunction-associated steatotic liver disease (masld) is the latest term for steatotic liver disease associated with metabolic syndrome. masld is a common cause of chronic liver disease and is the leading cause of liver-related morbidity and mortality. * the high prevalence of this disease has been fueled by the rapid rise in levels of sedentary behavior, low levels of physical activity, excess calorie intake relative to expenditure in nutritionally imbalanced and unhealthy diets. in parallel, the prevalence of poor metabolic health in adults from many countries is high, even in normal weight individuals. * masld has been estimated to affect 30% of the adult population worldwide, with its prevalence increasing from 22% to 37% from 1991 to 2019 . the increasing prevalence of masld parallels the increasing prevalence of obesity and obesity-related diseases.


Eligibility criteria:
inclusion criteria: * 100 employees in sohag university will be included in the study. exclusion criteria: employees with drug induced liver disease. employees with chronic liver disease. employees with decompensated liver cirrhosis. employees with excessive alcohol consumption.
effectiveness of experiential fibrowalk therapy

Conditions: Fibromyalgia

Summary: the present project will evaluate through a randomised controlled clinical trial with 4-month follow-up, the efficacy in clinical symptoms and quality of life (3-month time horizon) of the multicomponent experiential fibrowalk programme in treating individuals diagnosed with fibromyalgia, in compare with original fibrowalk and virtual fibrowalk. pre-post changes will be evaluated in various variables under investigation, will include kinesiophobia, physical function, anxiety, depression, physical dysfunction, overall impact, and symptom intensity. the design of the present study with 3 treatment branches: condition or disease fibromyalgia intervention/treatment behavioral: tau + experiential fibrowalk behavioral: tau + fibrowalk behavioral: tau + virtual

the objective of the experiential fibrolwalk study is to determine the clinical effectiveness of a new treatment protocol for individuals with fibromyalgia. this protocol was developed by identifying predictors of poor response and through collaboration between physiotherapists, clinical psychologists, and patients. the objectives of this 4-month controlled clinical trial are twofold. firstly, it aims to assess the impact of a protocol developed collaboratively by clinical therapists and users on the quality of life of individuals with fibromyalgia. secondly, it aims to determine the pre-post changes in kinesiophobia, physical function, anxiety, depression, physical dysfunction, overall impact, and symptom intensity. methods and analysis: the study will involve 120 fibromyalgia patients recruited from the central sensitivity syndromes specialized unit at vall d'hebron hospital's rheumatology service, who will be randomly assigned to one of three study groups: tau + experiential fibrowalk, tau + fibrowalk, tau + virtual. a comprehensive assessment to collect functional impact, depressive-anxiety symptoms, physical function, fatigue, kinesiophobia, pain catastrophism, impression of change,quality of life variables will be conducted pre-intervention, at half of the intervention (6 weeks), post-intervention (12 weeks), and at 3-month follow-up.

Eligibility criteria:
inclusion criteria: * adults from 18 to 75 years-old. * 1990 american college of rheumatology (acr) classification criteria + the 2011 modified acr diagnostic criteria for fibromyalgia * able to understand spanish and accept to participate in the study. exclusion criteria: * participating in concurrent or past rcts (previous year). * comorbidity with severe mental disorders (i.e. psychosis) or neurodegenerative diseases (i.e. alzheimer) that that would limit the ability of the patient to participate in the rct.

Keywords: fibromyalgia multicomponent treatment nature therapy mindfulness physical therapy pain science education (pse) psychological approach experiential therapy
randomized trial on robotic assisted resection for rectal cancer

Conditions: Rectal Cancer; Adenocarcinoma

Summary: hypothesis: the bladder and sexual functions can be better preserved in patients with robotic assisted rectal surgery this is a randomized trial comparing the bladder and sexual function of patients who undergo laparoscopic and robotic assisted rectal resection for rectal cancer.

this is a randomized trial comparing the bladder and sexual function of patients who undergo laparoscopic and robotic assisted rectal resection for rectal cancer the primary objective of this study is to compare the bladder and sexual functions of patients who undergo laparoscopic and robotic assisted resection for rectal cancer through a randomized controlled trial. the secondary outcome measures include 1. the operative outcome in terms of the complication rate, hospital stay and reoperation of the two groups; 2. the quality of life of the patients and the cost of the two groups 3. the quality of the resected specimens 4. the local recurrence rates at two years after the surgery

Eligibility criteria:
inclusion criteria: 1. histologically proven new case of rectal cancer with the lower border within 15 cm from anal verge 2. age \>18 years 3. informed consent obtained 4. american society of anesthesiologist class 1-3 5. no contraindication to laparoscopic surgery 6. acceptable operating risk exclusion criteria: 1. locally advanced fixed tumor with the need for exenterative surgery 2. severe cardiac or pulmonary comorbidity rendering pneumoperitoneum hazardous 3. multiple previous operations with the anticipation of dense peritoneal adhesions 4. no informed consent

Keywords: rectal cancer
multifocal electrophysiologic findings after intravitreal bevacizumab(avastin)treatment

Conditions: Diabetic Proliferative Retinopathy; Vascular Vein Oclussion; Choroidal Neovascularization

Summary: purpose: determine the short-term safety of intravitreal bevacizumab by multifocal electroretinography (mf-erg). methods: 120 eyes with choroidal neovascularization, proliferative diabetic retinopathy and retinal vein occlusion received intravitreal bevacizumab (2.5mg/0.1cc). all patients underwent best corrected visual acuity, fluorescein angiography, optical coherent tomography and mf-erg before and 1 month after treatment.


Eligibility criteria:
inclusion criteria: * proliferative diabetic retinopathy, vascular vein oclussion, choroidal neovascularization * multifocal electroretinogram before intravitreal bevacizumab and at 1,3, and 6 months after treatment * completely studies exclusion criteria: complications * tractional detachment * endophthalmitis