Kornimate/medical-research-clean huggingface dataset:
online pivotal response treatment training in autism spectrum disorder

Conditions: Autism Spectrum Disorder; Autism

Summary: this is a research study that will assess the effects of a pivotal response treatment online training course (prt-o) for training parents of children with autism spectrum disorder (asd). the study will specifically investigate whether participants can learn to deliver prt effectively following participation in the online training.


Eligibility criteria:
inclusion criteria: * 2:0 to 5:11 years at the time of consent, * diagnosed with asd (based on history, review of available medical records including diagnostic testing, e.g., autism diagnostic observation schedule) or suspicion of autism spectrum disorder diagnosis, and confirmed with autism diagnostic interview-revised (adi-r), * with significant adaptive communication deficits (i.e., either a vineland-3 communication subscale 2 standard deviations below average for 2 and 3 year olds and 3 standard deviations below for 4 and 5 year olds or a vineland-3 expressive v-scale score 2 standard deviations below average for 2 and 3 year olds, or 3 standard deviations below for 4 and 5 year old, and at least moderate severity on the clinical global impressions severity (cgi-s) language subscale), * an english-speaking parent able to consistently participate in study procedures and conduct treatment in english, * stable psychotropic medication(s) or biomedical intervention(s) for at least 1 month prior to baseline measurements with no anticipated changes during study participation, * stable treatment (aba, floortime, or other interventions), speech therapy, and school placement for at least 1 month prior to baseline measurements with no expected changes during study participation, * no more than 60 minutes of 1:1 speech therapy per week exclusion criteria: * children who have a primary language other than english * parent or child diagnosed with severe psychiatric disorder or unstable medical problem * previous adequate trial of pivotal response treatment resulting in parent meeting pivotal response treatment fidelity of implementation at baseline * receiving more than 15 hours of in home 1:1 aba per week

Keywords: pivotal response treatment parent training online course
outcomes of trasversus abdominis release for complex abdominal wall hernia

Conditions: Hernia, Abdominal; Hernia Incisional

Summary: this multicenter retrospective study analyzed data from 308 patients who underwent open posterior component separation with trasversus release for primary or recurrent complex abdominal hernias between 2015 and 2020. the primary endpoint was the rate of hernia recurrence and mesh bulging at 3, 6, 12, 24, and 36 months. secondary outcomes included surgical site events and were assessed using the pain scale.

study design this study is reported according to the strobe statement for cohort studies a retrospective multicentric study was conducted to analyze the surgical outcomes of patients undergoing open with posterior component separation with trasversus release for inisional hernia. it was conducted according to the ethical principles stated in the declaration of helsinki. written informed consent was obtained from all subjects. study setting and study population from january 2015 and may 2020, all the patients affected by primary or recurrent complex abdominal hernias undergoing open posterior component separation with trasversus release referring to 6 centers, were considered for enrollment in the study. inclusion criteria were age ≥16 years, primary or recurrent complex abdominal hernias with more than \>10 cm midline defects exclusion criteria were follow-up data lower than 36 months, patients with a stoma for whom closure was not planned during the abdominal hernia repair

Eligibility criteria:
inclusion criteria: * age ≥16 years, * primary or recurrent complex abdominal hernias with more than \>10 cm midline defects exclusion criteria: * follow-up data lower than 36-months, patients with a stoma for whom closure was not planned during the abdominal hernia repair
validation of novel bte and sp hearing aid models

Conditions: Hearing Loss

Summary: participants will wear one set of 2 different bte hearing aid models based on the gain required by their hearing loss. the hearing aids will be programmed based on a prescriptive approach and participants will be sent out for either one home trial with the less powerful btes or for two home trials with the sp (super power) btes.

during this study each participant will be asked to wear a set of bte hearing aids home and wear them daily. we will be assessing their evaluation of the btes during and after their home field trial. they will be asked to report on their use with different apps/accessories. subjective performance ratings will be collected.

Eligibility criteria:
inclusion criteria: * hearing aid candidacy (n2-n7 hearing loss) * healthy outer and middle ears * ability to complete questionnaires * willingness to use smartphone * informed consent documented by a signature * willingness to wear a binaural bte fitting * willingness to use app and accessories * willingness to adhere to covid protocols exclusion criteria: * contraindications to the md in this study: known hypersensitivity or allergy to investigational product/earmold * limited mobility/not able to attend appointments * limited ability to describe listening impressions/experiences * inability to produce a reliable hearing test result * limited dexterity - to point that participant cannot manage hearing aid insertion/removal * known psychological disorders
the effect of hydrogen rich water intake on acute body response and following recovery after 5 km run in untrained men

Conditions: Athletic Performance; Muscle Fatigue; Oxidative Stress

Summary: the aim of this randomized, double blinded, placebo controlled cross-over study is to evaluate the effect of hydrogen rich water intake on running performance, physiological and biochemical variables during endurance exercise and following recovery in endurance-untrained men.

this study involves 16 endurance-untrained men aged 18-30 years. all participants drink hydrogen rich water (hrw) or placebo during the two days before the experiment (total volume 2100 ml) and during the testing day (total volume 1680 ml). all participants undergo one laboratory session (entry diagnostic) and two experimental sessions in the field with a washout period of 7 days. in the two experimental sessions, participants receive hrw or placebo in a randomized order. each experimental session consisted of a pre-exercise phase, an exercise phase (5 km run), and a 24 h passive recovery phase. the following variables are assessed: running times (5 km distance and 200 m laps), heart rate, rating of perceived exertion, blood lactate, reactive strength index, subjective perceived muscle soreness, protein carbonyl content, malondialdehyde content, heart rate variability. statistical analysis is based on analysis of variance for repeated measures with the factors water (hrw and placebo), time, and interaction. fisher´s post hoc tests is used for pairwise comparison. the significance level is set at 0.05.

Eligibility criteria:
inclusion criteria: * no experience with endurance training. * good health condition. * signed informed content. exclusion criteria: * acute health problems. * not following instructions (free of any supplements three weeks before experiment, free of any medicaments, no caffeine at least 24 hours before experiment).
effect of androgel on atherogenesis in type 2 diabetic males with hypogonadotrophic hypogonadism

Conditions: Type 2 Diabetic Male With Hypogonadotrophic Hypogonadism

Summary: the purpose of this study is to examine the effects of testosterone deficiency in men with diabetes on atherogenesis, inflammation, cardiovascular risk factors and adiposity .

the purpose of this study is to examine the effects of testosterone deficiency in men with diabetes on atherogenesis, inflammation, cardiovascular risk factors and adiposity . this will be done by comparing the changes in several body response indicators following treatment with testosterone in diabetic men with low testosterone levels and comparing them to diabetic men with low testosterone who are not treated with testosterone. these groups will also be compared with diabetic men who have normal testosterone levels

Eligibility criteria:
inclusion criteria: * males with age 30-60 years inclusive. * psa \< 2.6 ng/ml or \< 3.75 ng/ml with a negative prostate biopsy in the last 6 months. * ipss ≤ 19. the lower age limit was decided on the fact that in our study on hypogonadotrophic hypogonadism in type 2 diabetic patients, the youngest subject was 31 years old. the upper age limit has been restricted to 60 to avoid including subjects with significant age-related declines in testosterone concentrations.subjects on thiazolidinediones, statins, ace inhibitors, angiotensin receptor blockers or antioxidants will be allowed as long as they are on stable doses of these compounds and the dosage in not changed during the study. subjects on insulin, metformin or sulfonylureas can participate in the study, provided that minimal changes are made to the doses during the study exclusion criteria: * coronary event or procedure (myocardial infarction, unstable angina, coronary artery bypass, surgery or coronary angioplasty) in the previous four weeks; 2)hemoglobin a1c \>10%; * h/o prostate carcinoma; * hepatic disease (transaminase \> 3 times normal) or cirrhosis; * renal impairment (serum creatinine \> 1.5); * hiv or hepatitis c positive status; * participation in any other concurrent clinical trial; * any other life-threatening, non-cardiac disease; * use of over the counter health supplements which contain androgens; * use of an investigational agent or therapeutic regimen within 30 days of study. * use of testosterone in the past * hematocrit \> 50%.
comparison sacral erector spinae block versus caudal block

Conditions: Postoperative Pain

Summary: the purpose of this research study is to find the best way to decrease pain in children whom have had hypospadias surgery. investigators will perform two technique; caudal block or sacral erector spinae block. the results of this study will help learn how to best control pain in children having surgery hypospadias surgery.

children aged 1-9 years undergoing hypospadias surgeries would be recruited in this randomized study. children would be monitored by electrocardiogram, pulse oximeter and non-invasive blood pressure. after preoxygenation for three minutes, anesthesia would be induced with 8% sevoflurane inhalation in 50% oxygen and % 50 air ; 1ug/kg fentanyl and 3 mg/kg propofol is administered intravenously. then laryngeal mask is inserted when conditions are satisfactory (jaw relaxed, lash reflex disappeared, no coughing, gagging, swallowing).after ethical committee approval, informed written consent will be obtained from all patients. consenting patients scheduled to have hypospadias surgery will be randomised to sacral erector spinae block or caudal block at the begin of surgery. all patients heart rate,map and oxygen saturation record intraoperatively. all patients will receive paracetamol if requirement for postoperative analgesia.all patient will transfer from pacu to day-surgery unit (dsu) if they achieved modified aldrete score of ten. all patients will be assessed postoperatively by a blinded investigator: in the postanesthesia care unit and at 30 min 1,2, 4, 6, 12, 24, hour postoperatively.flacc score will be used.

Eligibility criteria:
inclusion criteria: 1. age 1-9 2. asa physical status i-ii 3. undergoing unilateral low abdominal surgery exclusion criteria: 1. history of developmental delay or mental retardation, which will make observational pain intensity assessment difficult 2. parent refusal 3. history of allergic reactions to local anesthetics 4. rash or infection at the injection site 5. anatomical abnormality 6. bleeding diatheses 7. coagulopathy 8. history of diseases renal hepatic cardiac upper or lower airway neurologica
moderate weight loss makes obese patients with severe chronic plaque psoriasis responsive to sub-optimal dose of cyclosporine: an investigator blinded, controlled, randomized clinical trial

Conditions: Chronic Plaque Psoriasis; Obesity

Summary: the study hypothesis is to investigate whether a moderate weight loss (i.e. a weight reduction of at least 5%) could improve the response rate to a suboptimal dose of cyclosporine in patients with severe psoriasis.


Eligibility criteria:
inclusion criteria: * 18 years of age,active but clinically stable plaque psoriasis involving at least 10 percent of the body surface area and a psoriasis area and severity index (pasi) score ≥10 and a body mass index ≥30. exclusion criteria: * other type of psoriasis (guttate, erythrodermic and pustular psoriasis) * uncontrolled hypertension * severe congestive heart failure * renal and liver impairment * active or chronic infections, including hiv, hbv and hcv infections, latent tuberculosis * previous or active malignancies * pregnancy and lactations * previous treatment with cyclosporine * phototherapy or any systemic or topical therapy for psoriasis within the previous 4 weeks before enrolment.
impact of the diagnosis of celiac disease

Conditions: Celiac Disease

Summary: the main purpose of this study is to assess the impact of the diagnosis of celiac disease on general health, healthcare resource utilization, quality of life and lifestyle. we hypothesize that diagnosis and subsequent dietary treatment may have positive impact on these variables.

all new members with biopsy-proven celiac disease joining the finnish celiac society will be categorized in three groups according to symptoms and signs leading to the diagnosis as classical symptoms, extraintestinal symptoms and screen-detected, the latest being further divided to those presenting with symptoms and those who are totally asymptomatic. several parameters assessing general health and well-being, quality of life and healthcare resource utilization are evaluated at baseline and after one and five years on trial. quality of life is compared to that of non-celiac controls.

Eligibility criteria:
inclusion criteria: * diagnosis within one year * biopsy-proven diagnosis exclusion criteria: * celiac disease diagnosis previously than within one year * no biopsy-proven diagnosis

Keywords: celiac disease gluten-free diet screen-detected asymptomatic quality of life self-perceived health healthcare resource utilization
pet imaging of fibroblast activation in atherosclerosis

Conditions: Atherosclerosis

Summary: fibroblast activation protein (fap) is a fibroblast-specific marker expressed in atherosclerosis, associated with endothelial-to-mesenchymal transition and a rupture-prone plaque phenotype. this study aims to evaluate in-vivo fibroblast activation in carotid and coronary atherosclerotic diseases with fapi pet and its correlation with histological vulnerability and clinical outcome.

fibroblast activation protein (fap) is a fibroblast-specific marker expressed in atherosclerosis. abundant fap-expressing cells in atherosclerotic plaques co-express endothelial biomarkers involved in endothelial-to-mesenchymal transition. fap upregulation is also associated with a rupture-prone plaque phenotype with a thin fibrous cap. positron emission tomography (pet) with 68ga-fapi-04 has been demonstrated as a feasible method to image fibroblastic activation in the arterial wall. the current study aims to evaluate in-vivo fibroblast activation in carotid and coronary atherosclerotic diseases with fapi pet and its correlation with histological vulnerability and clinical outcome.

Eligibility criteria:
inclusion criteria: * for the carotid stenosis group: patients with symptomatic carotid stenosis with \>50% stenosis on carotid cta; or patients with unsymptomatic carotid stenosis with \>70% stenosis on carotid cta * for cad group: patients with stable ischemic heart disease or acute coronary syndrome, including st-elevation mid, non-st elevation mi, and unstable angina * signed informed consent exclusion criteria: * pregnancy, lactation, or intention to become pregnant during the study * contradiction to mri or cta
clinical trial of endoscopically guided injection of exparel (bupivacaine) for the treatment of craniofacial pain

Conditions: Craniofacial Pain; Migraine; Cluster Headache; Trigeminal Autonomic Cephalgia; Sphenopalatine Ganglion Neuralgia; Paroxysmal Hemicrania

Summary: exparel has a proven efficacy in providing pain relief for up to 72 hours with a single-dose administration at surgical sites. the study aims to evaluate the effectiveness of endoscopically-guided injection of exparel (bupivacaine) for the treatment of craniofacial pain. this study would be conducted in a prospective, randomized, double-blinded, placebo- controlled, and cross-over fashion. we aim to investigate whether the administration of exparel (bupivacaine) to the lateral nasal wall may positively impact craniofacial pain and functional outcomes, in patients who experience relief with the topical application of lidocaine (routinely given prior to almost all ent endoscopy).


Eligibility criteria:
inclusion criteria: * patients with a chief complaint of craniofacial pain (migraine, cluster headache, trigeminal autonomic cephalgia, sphenopalatine ganglioneuraligia, paroxysmal hemicrania) who has stanford pain \& ent clinic visit exclusion criteria: * age \ 80 * pregnant women * economically disadvantaged (not able to afford clinic visits/treatments) * decisionally impaired (unable to obtain informed consent) * has allergy to bupivacaine * unable or unwilling to participate plans to participate in another clinical study at any time during this study
assessment of flow with the new four-dimensional velocity-encoded magnetic resonance imaging technique

Conditions: Congenital Heart Disease (CHD)

Summary: the purpose of our study is to validate the accuracy of 4d pc flow method in quantification of thoracic and upper abdominal blood flow volumes in children. in this validation study, 4d pc flow method will be applied in 100 pediatric patients undergoing clinically indicated cmr with 2d pc flow measurement.

measurement of blood flow in vessels leading to or arising from the heart is one of the key features of cardiac magnetic resonance (cmr). with standard 2d phase contrast (pc) flow measurements, each vessel is measured separately at a predefined location. planning and scanning can be time consuming while the patient is inside the scanner. in addition, when the scan time is long, the hemodynamics may be assessed at different physiological states. in contrast to a 2d pc acquisition 4d pc captures all the information about blood flow velocities within a 3d anatomical volume. once this predefined volume has been acquired, the flow within the heart and vessels of interest can be measured at any desired location offline, i.e. after the patient has left the scanner. this is especially advantageous in cases where multiple 2d pc mri scans are needed such as in congenital heart disease (chd). in addition to standard measurements, 4d pc provides flow patterns, which might change our current understanding of pathologic flow conditions. although there has been increasing interest in this new technique, only a few papers have proved its accuracy in adult population. the purpose of our study is to validate the accuracy of 4d pc flow method in quantification of thoracic and upper abdominal blood flow volumes in children. in this validation study, 4d pc flow method will be applied in 100 pediatric patients undergoing clinically indicated cmr with 2d pc flow measurement.

Eligibility criteria:
inclusion criteria: * all pediatric patients under 18 years of age undergoing cmr with 2d pc flow measurements as a clinically indicated component of the examination at the hospital for sick children, toronto, on. * ability to undergo an mri examination without anesthesia or sedation. * ability to undergo an mri examination using 'feed-and-sleep' technique39 exclusion criteria: * refusal of consent / assent by parent / legal guardian / patient * general contraindications for an mri examination such as non-mri compatible metallic implants, claustrophobia. * patients who require anaesthesia or sedation for mri
comparing personalized and adaptive cognitive training methods following stroke

Conditions: Stroke; Cognitive Training

Summary: this study aims to assess the efficacy of two cognitive training programs - one tablet-based (neuroaireh@b) and one in paper-and-pencil format (task generator) - in improving cognitive and noncognitive outcomes among community-dwelling stroke survivors. this study will include a waiting-list control group to assess the impact of these interventions and provide further insights into their potential for stroke survivors.

the investigators plan to conduct a multicentric clinical trial with 45 participants randomly assigned to one of three groups. the study will have three arms, with each group receiving one of the following interventions: table-based cognitive training (neuroaireh@b), paper-and-pencil cognitive training (task generator) or no intervention (waiting-list control group). the latter group will not receive intervention during the study but will be offered the opportunity to participate in one of the cognitive training programs after completing the study. additionally, the investigators will assess participants at three different time points: before the intervention (pre-intervention), immediately after the intervention (post-intervention), and three months after the intervention (follow-up).

Eligibility criteria:
inclusion criteria: * stroke diagnosis; * maximum age: 75 years old; * education: at least three years of formal education; * relatively preserved language abilities (expressive and receptive language); * residing in the community; * availability to go to the hospital 2x/week; * preserved visual and auditory acuity; * physically able to operate the tablet and perform the paper-and-pencil training; * motivation to participate. exclusion criteria: * diagnosis of concomitant neurological and/or psychiatric disorders; * hemianopsia; * unilateral neglect; * aphasia syndromes.
nalbuphine and flurbiprofen for oculoplastic surgery

Conditions: Surgery; Anesthesia; Pain

Summary: the purpose of this study is to evaluate the postoperative pain and discomfort using flurbiprofen axetil or nalbuphine administration after oculoplastic surgery under general anesthesia.

in this randomized controlled clinical trial, we evaluated the postoperative analgesic efficacy and adverse effects of flurbiprofen axetil combined with nalbuphine in patients undergoing oculoplastic surgery compared with a single dose of flurbiprofen axetil or nalbuphine.

Eligibility criteria:
inclusion criteria: * undergoing oculoplastic surgery * age between 16 and 75 years * american society of anesthesiologists (asa) physical status of i-ii exclusion criteria: * serious coexisting disease * body mass index (bmi) \ 35 * contraindications or previous adverse reactions to any of the drugs used * females with a positive pregnancy test * patients unable to cooperate

Keywords: postoperative pain general anesthesia postoperative discomfort