Kornimate/medical-research-clean huggingface dataset:
effects of a high-intensity progressive-cycle program on quality of life and motor symptomatology in parkinson's disease

Conditions: Parkinson Disease; Exercise; Physical Activity; Quality of Life

Summary: title: effects of a high-intensity progressive-cycle program on quality of life and motor symptomatology in parkinson's disease population background: the benefits of aerobic exercise in persons with parkinson's disease (pd) have been widely studied; however, little research has been done on the effect of high-intensity aerobic exercise in this group. hypothesis: the high-intensity aerobic training in pedaliers, combined with balance training, improves motor symptoms and quality of life in a population with parkinson disease, hoehn \& yahr 1-3. objetives: to ascertain whether high-intensity aerobic training with exercise peddlers and balance training can improve motor symptoms and quality of life in a pd population of hoehn \&yahr (h\&y) disability score 1-3. methodology setting: rehabilitation centers in secondary care. design: a pilot randomized controlled trial. participants: a total of 14 patients participated in the 8-week study. interventions: they were comprised of a control group (n=7) that followed a balance protocol and an experimental group (n=7) that performed high intensity (70%) aerobic workout using an exercise peddler + a balance protocol once a week. main outcome measures: the primary outcome measures included the 8-foot up and go, test, 6-minute walk test, test 2-minute step tets, parkinson disease questionnaire-39 (pdq39), unified parkinson's disease rating scale (mds-updrs) and tinetti test.


Eligibility criteria:
inclusion criteria: * diagnosed with parkinson disease, hoehn \& yahr score of 1-3. exclusion criteria: * history or evidence of dementia or other neurological impairment/cardiovascular diseases that may affect the high-intensity endurance workout

Keywords: neurodegenerative disorders physical activity balance endurance
a study of the effectiveness of sitaxsentan sodium in patients with diastolic heart failure

Conditions: Diastolic Heart Failure

Summary: the aim of this study was to determine whether long-term (≥ 6 months at the target dose) blockade of eta receptors using sitaxsentan showed functional benefit in subjects with chronic heart failure and an left ventricular ejection fraction ≥50%.


Eligibility criteria:
inclusion criteria: * 18 or older with chronic heart failure and evidence of diastolic dysfunction on echocardiogram, heart imaging, and a minimum exercise tolerance average time of 120 seconds on two treadmill tests within 2 weeks of enrollment exclusion criteria: * unstable cardiovascular disease within 4 weeks of screening, history of heart attack, cardiac by-pass surgery or percutaneous intervention, stent placement, within 3 months of screening or amyloidosis, hypertrophic obstructive or restrictive cardiomyopathy, or constrictive pericarditis
post occlusive reactive hyperemia on gingiva assessed by laser speckle contrast imaging

Conditions: Ischemia

Summary: apply the lasca for follow-up the postocclusive microcirculation after strangulation of the gingiva in order to characterize the kinetics of the blood flow changes in human subjects.

during surgical endodontics the cortical bone is exposed by elevating a full- thickness tissue flap. cutting across mucosal blood vessels disturbs perfusion and causes ischemia. on the other hand, preserving sufficient blood flow of the soft tissue segment is important for the postoperative wound healing. in order to minimize the damage of the microvasculature of the operated area, the incision should be properly designed. the investigators will model surgical incisions by strangulation of the gingiva of healthy human subjects based on the commonly applied endodontic incision such as horizontal, vertical and papilla base. the primary aim is to determine the effect of a short term disruption of the blood flow at the respective region on the surrounding area in order to assess the functionally active collateral circulation. using laser speckle contrast analysis (lasca), which provides blood perfusion data, the investigators will have the possibility to detect functional alterations in gingival microcirculation during and after a short term of strangulation. the secondary aim is to assess the time course of the restoration of the circulation on the affected area.

Eligibility criteria:
inclusion criteria: * general good health exclusion criteria: * pregnancy * smoking * general diseases * medicine taking except contraceptives
hypnosis for eye surgery

Conditions: Cataract

Summary: perioperative stress for cataract surgery in the elderly is considerable even in the absence of pain. for these patients with a high comorbidity level, the perioperative situation comprising factors such as uncomfortable positioning, dull ambience, face cover, poor sedation, and anxiety might not only reduce intraoperative compliance but induce cardiac ischemia and hypertensive crises. hypnosis is supposed to increase patient comfort, to shield the patient from organic stress and to improve intraoperative compliance without side effects even in old and very ill patients. in a controlled study, we, the investigators at the university of heidelberg, compared phakoemulsification under topical anesthesia as usual (and placebo hypnosis) with either additional hypnosis or hypnoanalgesia without topical anesthesia.


Eligibility criteria:
inclusion criteria: * cataract exclusion criteria: * uncorrected hearing disability * pharmacological beta-blockade

Keywords: cataract surgery hypnosis c11.510.245 f04.754.424.771 suggestion
iontophoresis versus ultrasound in mechanical neck pain

Conditions: Trigger Point Pain, Myofascial

Summary: to investigate the effects of magnesium sulphate iontophoresis versus high power pain threshold ultrasound on pain, function and range of motion on active mtrps found in the upper trapezius.

myofascial pain syndrome (mps) is a musculoskeletal chronic pain disorder that affects the majority of pain population and characterized by the presence of trigger points. mps is usually associated with tenderness, spasm, movement limitation and referred pain . myofascial trigger points (mtrps) are hyperirritable taut fibers of skeletal muscle. the taut fibers within the muscle create palpable nodules that may cause local pain, and refer pain elsewhere with soft tissue examination .

Eligibility criteria:
inclusion criteria: * subjects, with age ranged from 19-23 years (forman et al, 2014) from both genders. the subjects had active mtrps in the upper fibers of trapezius muscle. exclusion criteria: * • history of whiplash injury. * history of cervical spine surgery. * cervical radiculopathy or myelopathy. * having undergone physical therapy within the past three months before the study. * non- rheumatologic diseases as multiple sclerosis, thyroid dysfunction and chronic infection. * rheumatologic condition as poly-articular osteoarthritis, rheumatoid arthritis and advanced cervical spine degenerative diseases.
single-layer robot-assisted transperitoneal retroperitoneal tubeless radical nephrectomy

Conditions: Nonfunctional Kidney; Renal Cancer

Summary: to investigate the effect of single-layer robot-assisted retroperitoneal approach for radical nephrectomy without tubularization

in this study, a multi-center retrospective study was conducted to evaluate the clinical efficacy of single-layer robot-assisted peritoneal retroperitoneal radical nephrectomy in patients with nephrectomy, and to compare the safety and effectiveness of traditional robot-assisted peritoneal radical nephrectomy

Eligibility criteria:
inclusion criteria: * patients with various causes requiring radical nephrectomy exclusion criteria: * patients who could not tolerate laparoscopic surgery for various reasons * patients whose preoperative blood pressure and blood glucose were not controlled to normal * patients with contralateral nonfunctioning kidney or solitary kidney * multiple organ surgery at the same time

Keywords: laparoscopic radical nephrectomy transperitoneal approach robotic surgery tubeless
reliability testing of silverman-andersen retraction score in preterm infants

Conditions: Premature Birth

Summary: depending on their gestational age, preterm infants need several weeks with different types of breathing-support due to immature development of the lungs, respiratory muscles, chest-wall and respiratory center in the brain. who's recommendation on interventions to improve preterm birth outcomes underline the need for more research on respiratory support in infants born preterm. this study will test inter-rater and intra-rater reliability of the silverman-andersen retraction score, which is a systematic clinical scoring tool for the respiratory work and the severity of respiratory distress in preterm infants. it will examine if there is consistency in the assessments done by doctors and nurses, and also if the observations correlate with technological monitoring. this easy to use scoring tool will help to determine the grade of respiratory distress, to assess respiratory exacerbation, to decide when to start weaning from respiratory support, and to give the best respiratory treatment to the child. this study will contribute to optimize care for preterm infants with respiratory distress.


Eligibility criteria:
inclusion criteria: * born \<35 weeks gestational age exclusion criteria: * need of muscle relaxation * hemodynamic instability

Keywords: lung/growth & development respiration, artificial reproducibility of results observer variation
signature for precise chemosensitivity prediction in pdac

Conditions: Pancreatic Cancer

Summary: pancreatic ductal adenocarcinoma (pdac) is largely heterogeneous. we sought to develop and validate a signature to precisely predict chemotherapy sensitivity in pdac. genetic events of the four most commonly mutated genes in pdac and expressions of 12 pi3k/akt/mtor pathway markers were examined in consecutive patients with pdac. a 9-feature signature for prediction of chemotherapy benefits was constructed using the lasso cox regression model, and validated in two independent cohorts.


Eligibility criteria:
inclusion criteria: * ecog performance status score of 0-1 before resection * complete clinicopathologic and follow-up data * availability of formalin-fixed paraffin-embedded (ffpe) specimens of resected primary tumor and hematoxylin and eosin slides with invasive tumor components exclusion criteria: * any previous history of cancer * any anticancer therapy prior to resection or adjuvant radiotherapy * metastatic cases * major postsurgical complications with clavien-dindo grade ≥2
clinical evaluation of two toric contact lenses in current non-toric lens users

Conditions: Astigmatism

Summary: the purpose of this study is to evaluate the clinical performance, defined as successful fit, of two toric contact lenses (one daily disposable and the other daily wear reusable contact lens to correct astigmatism) in current spherical soft contact lens wearers, contact lens drop-outs, and non-users of toric contact lenses (neophytes).


Eligibility criteria:
inclusion criteria: subjects must satisfy the following conditions prior to inclusion in the study: 1. one of the following: 1. spherical contact lens user (minimum of 2 months wear, four days a week, 8 hours a day) 2. contact lens drop-out (no contact lens wear in the last 6 months but wearing glasses at least four days a week,8 hours a day) 3. neophyte (no habitual contact lens wear except for trial fits up to 1 week, but wearing glasses at least four days a week,8 hours a day for patients not currently wearing lenses, patient should have expressed a desire to try lenses. 2. between 16 and 60 years of age. 3. have signed an informed consent form (documented by the investigator in the case report form \[crf\]). 4. distance requirement in the range of +4.00d to -9.00d (i.e. -10.00d refractive) 5. refractive astigmatism between -0.75d and -3.00d in both eyes. 6. have best corrected va of 6/9 (20/30) or better in each eye. 7. have normal eyes with no evidence of abnormality or disease. for the purpose of this study a normal eye is defined as one having: 1. no amblyopia. 2. no evidence of lid abnormality or infection. 3. no conjunctival abnormality or infection. 4. no clinically significant slit lamp findings (i.e. stromal haze, staining, scarring, vascularisation, infiltrates or abnormal opacities). 5. no other active ocular disease. 8. presbyopes may be included (no monovision, no spectacles over contact lenses or bifocal glasses only) exclusion criteria: any of the following will render a subject ineligible for inclusion: 1. requires concurrent ocular medication. 2. clinically significant (grade 3 or 4) corneal stromal haze, corneal vascularisation, tarsal abnormalities, bulbar hyperaemia, limbal hyperaemia, or any other abnormality of the cornea that would contraindicate contact lens wear. 3. corneal staining grade 3 in more than two regions. 4. extended wear in the last 3 months. 5. has had any anterior ocular surgery. has had any other ocular surgery or injury within 8 weeks immediately prior to enrollment for this study. 6. abnormal lachrymal secretions. 7. pre-existing ocular irritation that would preclude contact lens fitting. 8. keratoconus or other corneal irregularity. 9. any systemic illness which would contraindicate lens wear or the medical treatment of which would affect vision or successful lens wear. 10. has diabetes. 11. infectious disease (e.g., hepatitis, tuberculosis) or an immunosuppressive disease (e.g., hiv). 12. pregnancy, lactating, or planning a pregnancy at the time of enrollment. 13. participation in any concurrent clinical trial or in last 60 days.
a study of zg005 combined with donafenib in patients with advanced solid tumor

Conditions: Solid Tumor

Summary: this is a multi-center, open-labe, phase i/ii study to evaluate the safety and tolerability of zg005 combined with donafenib in patients with advanced solid tumor.


Eligibility criteria:
inclusion criteria: * fully understand the study and voluntarily sign the informed consent form. * male or female 18-70 years of age; * eastern cooperative oncology group (ecog) performance status of 0 or * life expectancy ≥ 3 months. exclusion criteria: * patients were deemed unsuitable for participating in the study by the investigator for any reasons.
effect of cervical collar in cervical radicular pain.

Conditions: Cervical Radicular Pain

Summary: objectives:the purpose of this study is to determine if use of nech collar (stiff or soft)will improve the possibility to obtain painrelief in patients with cervical radicular pain. we will compare short term (six weeks and three months) and long term ( one year) effect of six weeks use of neck collar (stiff or soft)together with "neck school information" with "neck school information" alone.


Eligibility criteria:
inclusion criteria: * cervical radicular pain caused by herniated disc og spondolytic spurs * written consent from patient exclusion criteria: * previous necksurgery * whiplash or other necktrauma * serious diseases somatic or psychiatric * patients not able to speak and read norwegian well * insufficient correlation between clinical and radiological findings

Keywords: cervical intervertebral disc displacement cervical spondylosis radiculopathy neck collar brace physiotherapy treatment rehabilitation
effects of butyrate on colonic health of patients with diarrhoea predominant ibs and uc in remission

Conditions: Gut Health

Summary: short chain fatty acids (mainly butyrate, acetate, and propionate) are produced in the large intestine by bacterial fermentation of undigested carbohydrates, such as dietary fibres. butyrate is an important energy source of the intestinal epithelium and has a pivotal role in the regulation of epithelial cell proliferation and differentiation, immune function and mucosal protection. non-digestible carbohydrates (prebiotics) increase the concentrations of colonic butyrate, which has been proposed to be responsible for its beneficial effects. furthermore, butyrate enemas have been proven to be effective in the treatment of active ulcerative colitis. in the present study, the direct effects of butyrate on inflammation and parameters of colonic defence and mucosal integrity of the distal colon will be studied in 40 patients with diarrhoea predominant ibs (d-ibs) and 40 patients with ulcerative colitis in remission (ucrem) using rectal enemas. these patients groups were chosen because they have a low-grade inflammation in the large intestine, and can therefore be used as a model to study the mechanistic effects of butyrate. the design used to study the effects of butyrate in both patient groups will be a double blind randomized placebo-controlled parallel design.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of uc or diarrhea predominant ibs * stable western diet * age between 18 and 65 * bmi between 18 and 35 * written informed consent exclusion criteria: * all enemas and suppository during or 2 weeks prior to the study * use of corticosteroids during or 1 month prior to the study * use of antibiotics during or 3 months prior to the study * budesonide during or 2 weeks prior to the study * changes in medication during or 1 month prior to the study * lactation, pregnancy and planning of pregnancy * previous intestinal surgery * clinically significant systemic diseases * excessive drinking (\>20 alcoholic consumptions per week) * changes in prebiotic and/or probiotic use during and 2 weeks prior to the study * previous radiotherapy or chemotherapy
docetaxel in the treatment of hormone refractory prostate cancer

Conditions: Prostatic Neoplasms

Summary: evaluation of safety and efficacy of docetaxel in the treatment of advanced hormone refractory prostate cancer under the conditions of daily practise.


Eligibility criteria:
the following information on clinical trials is provided for information purposes only to allow patients and physicians to have an initial discussion about the trial. this information is not intended to be complete information about the trial, to contain all considerations that may be relevant to potential participation in the trial, or to replace the advice of a personal physician or health professional. main criteria are listed hereafter : inclusion criteria: * patients with advanced prostate cancer, without previous chemotherapy, progressing on hormonal treatment, performance status 1 to 2 exclusion criteria: * other cytostatic treatment, other malignity, severe comorbidity
efficacy of nonselective beta blocker vs placebo in patients with acute-on-chronic liver failure with small/ no esophageal varices

Conditions: Acute on Chronic Liver Failure

Summary: acute on chronic liver failure patients with hvpg (hepatic venous pressure gradient) ≥ 12 mmhg + no/small esophageal varices who present to the department of hepatology at institute of liver and billiary sciences, who meet the inclusion criteria and who provide informed consent.


Eligibility criteria:
inclusion criteria: 1. acute on chronic liver failure as per apasl (asian pacific association of study of liver disease) criteria. 2. 18-75 years 3. hvpg ≥ 12 + no/small esophageal varices exclusion criteria: 1. bradycardia (hr \< 60/ min) 2. hypotension 3. asthma 4. lvf 5. aki (acute kidney injury), (s.creat \>1.5) 6. refractory ascites 7. sbp (spontaneous bacterial peritonitis) 8. pregnancy or lactation 9. past history of evl or est 10. significant cardio - pulmonary co-morbidity 11. pvt 12. presence of grades 3-4 hepatic encephalopathy (he) 13. patients going for liver transplant in next 12 weeks 14. no consent
catheter system feasibility clinical trial

Conditions: Renal Insufficiency, Chronic

Summary: feasibility clinical study to evaluate the safety and effectiveness of the catheter system for the percutaneous creation of an arteriovenous fistula for patients with end stage renal disease requiring dialysis access.


Eligibility criteria:
inclusion criteria: * patients deemed medically eligible for av fistula creation per institutional guidelines and/or clinical judgment * patients diagnosed with chronic kidney disease classification stage iv or v * adequate quality vein \>= 2 mm with confirmed clinically significant outflow based on pre-operative assessment * adequate quality radial artery \>= 2 mm based on pre-operative assessment * adequate collateral arterial perfusion * radial artery-adjacent vein proximity \< = 1.5 mm * able to provide informed consent * able to travel to institution for follow up examination * able to intraoperatively place an .014" guidewire in artery exclusion criteria: * suspected skin disease * immunocompromised patients (e.g. hiv positive) * edema of extremities * current diagnosis of carcinoma * pregnancy or currently breast feeding * diagnosed hypercoaguable state * active infection * evidence of vascular disease at target site * pre-existing vascular disease that could confound study results * vessel tortuosity or spasm preventing placement of .014" guidewire
levitra® - real life safety and efficacy of levitra

Conditions: Erectile Dysfunction

Summary: collect data on safety, efficacy, and subject acceptance of vardenafil treatment under daily life conditions in a large number of subjects with erectile dysfunction (ed)


Eligibility criteria:
inclusion criteria: * male outpatients \>/= 18 years of age with a diagnosis of ed according to the 1992 us national institutes of health (nih) consensus statement (the inability to achieve and maintain penile erection sufficient to complete satisfactory intercourse), and independent of any previous ed treatment exclusion criteria: * exclusion according to us pi

Keywords: erectile dysfunction vardenafil
spectral dynamic imaging of cognitive functions in epileptic patients explored stereoelectroencephalography

Conditions: Epilepsy

Summary: this prospective research aims to develop the use of spectral imaging in addition dynamics of cortical electrical stimulation to identify major anatomical and functional networks in epileptic patients candidates for surgery and explored by stereoencephalography, to minimize risk of post-surgical cognitive deficits.

cognitive deficits after epilepsy surgery are poorly known particularly because the tools used to evaluate them. in addition, the prevention of certain postoperative deficits, is extremely difficult because of the lack of robust markers to anticipate. the various examinations conventionally used for this purpose (neuropsychological testing, functional mri and cortical stimulation) does indeed provide insufficient information or difficult to interpret, so the development of improved methods appears as an imperative in the field of the epilepsy surgery. sid appears as such particularly adapted to the case of epileptic patients explored seeg to provide individualized cognitive map millimeter thereof without requiring, for additional invasive act, or risk of inducing unintended crisis. in practice, this clinical research project should lead to the definition of several simple cognitive tasks which, together, could be achieved by each volunteer patient in two or three hours, and then analyzed in a similar time to provide fast, even the patient is still explored seeg and even before cortical electrical stimulation, a list of brain regions involved in most major cognitive functions.

Eligibility criteria:
inclusion criteria: * drug-resistant partial epilepsy justifying a seeg exploration * intellectual capacities compatible with the award of cognitive tasks exclusion criteria: * pregnant or lactating women * patient deprived of liberty by a judicial or administrative * major patient subject to a measure of legal protection