Kornimate/medical-research-clean huggingface dataset:
prevalence and pathophysiology of systemic arterial pressure abnormalities in childhood sickle cell disease

Conditions: Sickle Cell Disease

Summary: it is usually found that the blood pressure of adults with sickle cell disease is lower than in non-sickle cell patients. on the other hand, three recent prospective studies in children with sickle cell disease show prevalence of hypertension diagnosed by ambulatory blood pressure measurement (abpm) ranging from 32 to 45% but on small numbers of patients (n = 54 at most). this hypertension appears to affect kidney function and has been previously associated with the risk of hemorrhagic stroke. it is therefore important to know the prevalence of hypertension in children with sickle cell disease and to determine its mechanisms. the factors which could explain this high prevalence are the increase in arterial stiffness and the increase in systemic vascular resistance linked to the alteration of the sympathovagal balance contributing to the regulation of vascular tone. indeed, a disturbance of this balance with an increase in vasoconstrictor sympathetic tone has already been found. hypothesis: in a subgroup of sickle cell children there is systemic hypertension (prevalence: main objective) linked to the alteration of the sympathovagal balance already established during sickle cell disease (increase in sympathetic tone and decrease in parasympathetic tone) affecting systemic vascular resistance (secondary pathophysiological objectives).

main objective (200 children): to evaluate the prevalence of elevated blood pressure (former pre-hypertension) and hypertension (including masked hypertension) in children with sickle cell disease. secondary objectives (60 children): to evaluate the prevalence of loss of nocturnal decrease in blood pressure (dipping); to evaluate arterial stiffness (pulse wave velocity: pwv) and vascular resistance (augmentation index, ai) in the different groups: normal, pre-hypertension and hypertension; to evaluate the cardiac sympathovagal balance by studying heart rate variability (hrv) in the three groups: normal, pre-hypertension and hypertension; to evaluate arterial in the three groups: normal, pre-hypertension and hypertension; to evaluate whether the absence of nocturnal dipping is or is not an associated factor of abnormal arterial stiffness, systemic vascular resistance, sympathovagal balance or baroreflex by comparison of subjects with normal dipping versus abnormal dipping.

Eligibility criteria:
inclusion criteria: * child (age \<18 years); * sub-saharan or caribbean origin; * major sickle cell disease (ss, sc and sbeta-thalassemia); * height ≥ 120 cm; absence of treated hypertension or antihypertensive treatment; * parents informed and not opposed to participation in research exclusion criteria: -

Keywords: sickle cell disease systemic hypertension
the effect of sevelamer carbonate on serum trimethylamine-n-oxide (tmao) level in patients with chronic kidney disease (ckd) stage 3b-4

Conditions: CKD Stage 3b; CKD Stage 4

Summary: the aim of this study is to investigate effects of sevelamer carbonate on reducing tmao in stage 3b-4 ckd (pre-dialysis) patients. the study will also investigate the safety and tolerability of sevelamer carbonate in study population and the effects of sevelamer carbonate on serum p-cresyl sulfate, indoxyl sulfate, ldl-c and uric acid.


Eligibility criteria:
inclusion criteria: * 1. men or women, aged from 18 to 75 years old; * 2. provide informed consent prior to enrolling in the study; * 3. estimated glomerular filtration rate (egfr) between 15-45 ml/min/1.73 m2 (calculated by ckd-epi equation) exclusion criteria: * 1. documented poorly controlled diabetes mellitus, poorly controlled hypertension, malignant tumour, or any clinically significant unstable medical condition; * 2. active dysphagia or swallowing disorder; or a predisposition to or current bowel obstruction, ileus, or severe gastrointestinal motility disorders including severe constipation; * 3. known hypersensitivity to sevelamer or any constituents of the study drug; * 4. unable to comply with the requirements of the study; * 5. hypophosphatemia (serum phosphorus level \<0.87mmol/l); * 6. women who have a positive pregnancy test at enrollment or women who are breast-feeding; * 7. have been enrolled in other interventional study; * 8. received sevelamer or other intestinal adsorbents, or broad-spectrum antibiotic within one month prior to the screening period.
bi 671800 in asthmatic patients on inhaled corticosteroids

Conditions: Asthma

Summary: this is a 6 week study to assess the effect of bi 671800 in patients with asthma. it is a double blind, parallel arm trial testing the safety and efficacy of bi 671800. the main objective is to assess the effect on lung function. the study will also provide data on the pharmacokinetics of bi 671800.


Eligibility criteria:
inclusion criteria: 1. signed informed consent consistent with ich-gcp 2. three month history of reversible (12% and 200 ml in forced expiratory volume in one second - fev1) asthma (according to gina) with following spirometry at randomisation: fev1 60%- 85%. 3. stable inhaled corticosteroids (ics) dose 3 months prior to screening. 4. diagnosis of asthma prior to 40 years. 5. asthma control questionnaire (acq) at least 1.5 at randomisation. 6. male or female 18 to 65 years. 7. non-smokers or ex-smokers (less than 10 pack years history) with negative cotinine screen. 8. able to perform pulmonary function testing. exclusion criteria: 1. significant diseases other than asthma or allergic rhinitis. 2. hepatic transaminases or total bilirubin greater than 1.5 uln. 3. hospitalisation for asthma exacerbation or asthma related intubation within 3 months. 4. uncontrolled asthma on ics + other controller. 5. respiratory tract infection or exacerbation within 4 weeks. 6. fev1 less than 40%, more than 12 puffs rescue salbutamol on more than two consecutive days, or asthma exacerbation during run-in period. 7. participation in another interventional study. 8. pregnant or nursing women. 9. women of child bearing potential not using appropriate methods of birth control as defined by the study protocol.
evaluation of the effect of pur118 on ozone induced airway inflammation in healthy normal volunteers

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: this trial in healthy subjects will assess pur118's effect on attenuating ozone induced airway inflammation. this trial will establish the tolerability of pur118 in healthy normal volunteers.


Eligibility criteria:
inclusion criteria: * healthy males or non pregnant, non lactating healthy females age 18-50 years; * must be able to produce acceptable sputum sample by induction; * must respond to ozone inhalation with a \> 10% increase in the absolute percentage of sputum neutrophils and the total neutrophils (neutrophils/gram sputum) must increase by at least 50% from the sputum neutrophil count at screening; * volunteer is a non-smoker or ex-smoker of at least 12 months' duration prior to screening with a history of less than 1 pack per year. exclusion criteria: * volunteers receiving chronic medication other than oral contraceptives; * screening forced expiratory volume fev1 is \< 80% of the predicted value for their age, gender, height and race and/or their fev1/fvc ration is below 70%; * volunteers with significant occupational exposure to respiratory irritants or toxins * upper respiratory tract infection within 30 days of the first study day, or lower respiratory tract infection within the last 3 months; * volunteers taking any medication that may affect the respiratory tract within 30 days of the first study day; * volunteers with a history of asthma

Keywords: inflammation copd respiratory disease healthy volunteers
comparison of dual-task timed up and go test (cognitive) and 3-m backwards walk test

Conditions: Stroke

Summary: two balance assessment tools that have been used recently have attracted considerable attention: the dual-task timed up and go test (cognitive) (dtug) and the 3-m backward walk test (3mbwt). the aim of this study is to compare the psychometric properties of two clinically proven balance assessment tools.

there are unidimensional and multidimensional scales used to evaluate gait balance after stroke. unidimensional scales (dtug, 3mbwt) can be useful in clinical practice and in screening for basic balance problems. two balance assessment tools that have been used recently have attracted considerable attention: the dual-task timed up and go test (cognitive) (dtug) and the 3-m backward walk test (3mbwt). the aim of this study is to compare the psychometric properties of two clinically proven balance assessment tools. in the study, construct validity, concurrent validity, reliability, and cut-off score (for determining falling risk) of the two tests will be calculated.

Eligibility criteria:
inclusion criteria: * single stroke with unilateral hemiparesis at least 6 months prior to the study, * be in the age range of 50-85 years * able to walk at least 10 meters independently with or without a walking aid, * getting at least 24 points from the standardized mini-mental test * it is to be able to follow two-stage commands and perform subtraction. exclusion criteria: * presence of additional orthopedic or neurological diseases that may affect balance and walking, * having uncorrected vision and hearing problems

Keywords: stroke falling reliability and validity postural balance
reiki therapy to improve key symptoms in integrative oncology clinic (reiki)

Conditions: Cancer Pain; Oncology Pain

Summary: the purpose of this research is to investigate the delivery of reiki to integrative oncology patients and assess its potential for improving cancer-related symptoms in this population.

reiki is a biofield therapy originating in japan, in which a trained practitioner places their hands on or above the body of a receiver or themselves to generate a relaxation and healing response. systematic reviews and meta-analyses report reiki to be effective for improving psychological and physical health symptoms. with respect to adults with cancer, reiki has been shown to improve participants' relaxation, pain, fatigue, sleep, anxiety, stress, and wellbeing/quality of life compared to care as usual. however, one study showed no improvement in comfort and wellbeing in those receiving reiki compared to sham reiki control, but those receiving reiki reported improvements above usual care.

Eligibility criteria:
inclusion criteria: * age 18 - 89. * neoplasm diagnosis (i.e., icd-10 c00 - d49) confirmed in electronic health record (ehr)/caisis * receiving care at a uh connor whole health integrative oncology clinic. * reporting at least three esas symptoms ≥4/10 at baseline screening including fatigue and ≥2 other symptoms on the 9-item questionnaire. * able to speak and understand english. * has an email address, and access to a computer with internet and/or a mobile device with a functioning data plan exclusion criteria: * significant cognitive impairment that has not been corrected. * significant visual impairment that has not been corrected. * unable to provide informed consent. * active psychosis. * pregnancy. * metastatic disease. * reiki therapy within 3 months of study enrollment * active immunotherapy, chemotherapy, or radiation treatment, or completed within 3 months before study start. aromatase inhibitors and tamoxifen are exceptions.

Keywords: reiki
quantitative analysis of myocardial uptake of bone radiopharmaceuticals in patients with cardiac attr amyloidosis

Conditions: Amyloidosis Transthyretin

Summary: introduction: transthyretin cardiac amyloidosis (attr) is an important cause of heart failure. cardiac planar radionuclide imaging using 99mtc-labeled bone seeking radiopharmaceuticals is used as a noninvasive diagnostic criterion in patients without detectable monoclonal protein. the visual assessment remains the main noninvasive criterion for the diagnosis. medical therapy using tafamidis meglumine that binds to transthyretin and prevents amyloidogenesis, recently demonstrated a reduction in all-cause mortality and cardiovascular-related hospitalizations. as a consequence, there is a need for quantitative approaches that would be useful for diagnosis and prognosis assessment but also for the evaluation of patient therapeutic response. materials and methods: the investigators aim to include 35 patients with a suspected diagnosis of cardiac attr amyloidosis in whom a cardiac planar radionuclide imaging using 99mtc-labeled bone seeking radiopharmaceuticals is planned as part of routine noninvasive diagnosis work-up. using a test-retest approach, the aim is to compare a quantitative method vs. conventional semi-quantitative approaches for the assessment of cardiac uptake of bone radiopharmaceuticals using new 3d czt-based spect-ct cameras in patients with suspected cardiac attr amyloidosis. the investigators estimated that 20 patients will have a diagnosis of cardiac attr amyloidosis. in the latter patients, the aim is to evaluate the impact of 6-month therapy using tafamidis on quantitative and semi-quantitative assessment of cardiac uptake of bone radiopharmaceuticals perspectives: this new non invasive imaging techniques for the quantitative assessment of the amyloid burden in patients with cardiac attr amyloidosis may help identify the responders and the patients who should benefit from dose intensification.


Eligibility criteria:
inclusion criteria: * medical history of heart failure (hf) with at least 1 prior hospitalization for hf or clinical evidence of hf (without hospitalization) manifested by signs or symptoms of volume overload or elevated intracardiac pressures that required/requires treatment with a diuretic for improvement, and an increase of bnp \>200 pg/ml and/or nt-probnp \>500 pg/ml * suspected cardiac attr amyloidosis * evidence of cardiac involvement by echocardiography with an end-diastolic interventricular septal wall thickness \> 12 mm * patient signed consent * contraception method exclusion criteria: * new york heart association (nyha) functional class iv despite diuretic treatment * life expectancy \<6 month due to the severity of cardiac amyloidosis and/or comorbidities * aortic valve surgical or percutaneous replacement within 30 days or planned within months * presence of primary (light chain) amyloidosis * contraindication to tafamidis * pregnancy and breast feeding ; pregnancy test in women of reproductive age irrespective of contraception method) * adults with protective measures
ocular imaging with spectral domain optical coherence tomography

Conditions: Healthy; Myopia; Hypermetropia

Summary: the purpose of this study is to analyze macular retinal thickness and macular volume using the spectral domain - optical coherence tomography (sd-oct) in normal eyes and in eyes with various ocular diseases.

assessment of macular thickness is important for the treatment and follow-up of a variety of ocular diseases. the introduction of optical coherence tomography (oct) has enabled clinicians to reliably detect small changes in macular thickness and to quantitatively evaluate the efficacy of different therapeutic modalities. in this study using the spectral domain-oct, we examined the variations of macular retinal thickness and macular volume in normal eyes and in eyes with various ocular diseases.

Eligibility criteria:
inclusion criteria: * normal eyes * myopic eyes * hypermetropic eyes exclusion criteria: * systemic illness * cataract * previous ocular trauma or surgery(other than cataract surgery or refractive surgeries)

Keywords: spectral domain-oct macular thickness myopia hypermetropia normal
the relationship between isolated head trauma during pregnancy and preterm birth

Conditions: Superficial Injuries Involving Head With Neck

Summary: pregnant patients who presented to the emergency department of şanlıurfa training and research hospital with isolated head trauma due between january 2018 and january 2024 were included in the study and followed up with until the time of pregnancy termination.

the criteria for inclusion in the study were as follows: all of the pregnant women over 18 years of age with isolated head trauma (closed blunt trauma) who were evaluated with neurosurgical consultation or computed tomography/magnetic resonance (ct/mri) and whose birth records are available at our hospital. the exclusion criteria included patients with previous premature birth, pregnancies in the first trimester, pregnancies with assisted reproductive techniques, multiple pregnancy, the threat of preterm labor or abortus imminens in the current pregnancy, maternal or fetal life-threatening situations that may cause termination of the pregnancy, cervical insufficiency, short cervix or history of conization, asymptomatic bacteriuria, periodontal disease, and smoking and substance use. patients who had trauma to the other parts of the body or placental abruption were also excluded. additionally, the study did not include those with missing hospital records regarding birth and pregnancy follow-up.

Eligibility criteria:
inclusion criteria: * all of the pregnant women over 18 years of age with isolated head trauma (closed blunt trauma) who were evaluated with neurosurgical consultation or computed tomography/magnetic resonance (ct/mri) and whose birth records are available at our hospital. exclusion criteria: patients with previous premature birth, pregnancies in the first trimester, pregnancies with assisted reproductive techniques, multiple pregnancy, the threat of preterm labor or abortus imminens in the current pregnancy, maternal or fetal life-threatening situations that may cause termination of the pregnancy, cervical insufficiency, short cervix or history of conization, diagnosis of asymptomatic bacteriuria, diagnosis of periodontal disease, smoking and substance use. patients who had trauma to the other parts of the body or placental abruption missing hospital records regarding birth and pregnancy follow-up. -

Keywords: cervical dilatation head trauma preterm birth placental abruption vaginal bleeding
acellular dermis in rotator cuff repair

Conditions: Rotator Cuff Tears; Rotator Cuff Injuries

Summary: to determine if an acellular dermal graft (adg) will incorporate into the rotator cuff and subsequently improve outcomes without an increase in risk to the patient

rotator cuff healing poses a significant clinical problem with re-tear rates between 20-50%. the final functional outcome following surgery correlates with healing, with those that completely heal performing best. failure of repair is mainly due to tendon failure both mechanically and biologically. if the healing and the structural properties of the tendon can be improved then significant functional gains may be achieved. this study will therefore utilise acellular dermal grafts to determine whether they could be used for to improve patient outcomes following surgery

Eligibility criteria:
inclusion criteria: 1. symptomatic rotator cuff tear that warrants operative intervention. 2. a tear measuring between 1-5cm at arthroscopy. 3. an arthroscopic rotator cuff repair. 4. written consent. exclusion criteria: 1. rotator cuff tears greater than 5cm and less than 1cm 2. clinical or radiological evidence of osteoarthritis affecting the index side. 3. patients involved in a compensation claim related to the shoulder. 4. inability to attend follow-up for 1 year and to a repeat mri scan. 5. previous shoulder surgery or proximal humeral fracture on the index side. 6. patients that are recruited in a current study

Keywords: rotator cuff shoulder surgery acellular dermal graft acellular dermis rotator cuff augmentation
effect of ccrt on respiratory performance and functional capacity in esophagus cancer patients

Conditions: Esophageal Cancer

Summary: the purposes of this study are to investigate in patients with newly diagnosed esophageal cancer: 1)changes in pulmonary and respiratory muscle function, functional capacity and quality of life during and after rt or ccrt treatment; 2)the correlations between these changes; and 3)the impacts of these changes on the postoperative pulmonary complications following esophagectomy.

background and purpose: incidence rates of esophageal cancer vary internationally with the higher rate found in eastern asia. preoperative concurrent chemoradiation therapy (ccrt) for resectable esophageal cancer has been shown to improve overall survival in meta-analyses. preoperative pulmonary function and functional capacity are known predictive factors for the development of postoperative pulmonary complications in patient undergoing major cancer surgery. little is known concerning the impacts of preoperative ccrt on pulmonary function and functional capacity in patients with esophageal cancer. the aim of this study is to examine changes of respiratory performance and functional exercise capacity during rt or ccrt, the relations between these changes, and the impacts of these changes on the postoperative outcomes in patients with esophageal cancer. method: patients with newly diagnosed esophageal cancer without metastasis will be recruited from the far eastern memorial hospital. demographic data will be obtained from the chart. respiratory muscle strength will be measured by maximal inspiratory and expiratory pressure. spirometric variables will be tested by force expiratory volume in one second and forced vital capacity. dyspnea will be measured using modified borg scale. functional exercise capacity will be measured by six minute walk distance. quality of life will be measured using eortc qol-c30 and qol-oes18 instruments. all the measurements will be repeated weekly during the concurrent therapy period. repeated measure anova will be used for analyzing difference among various time points. spearman correlation coefficient will be used to test relationship between multiple variables. for patients who are receiving esophagectomy after ccrt or rt, pulmonary complications and total length of hospital stay will be documented. clinical relevance: the results of this study will help to better understand the indications for chest physiotherapy (e.g., respiratory muscle weakness, reduced functional capacity, and their related sequels)

Eligibility criteria:
inclusion criteria: * primary esophagus cancer * planning to receive radiation therapy exclusion criteria: * mmse \< 24 * a clinical diagnosis affecting respiratory muscle function and functional activity performance * unstable angina or acute myocardial infarction prior 1 month of assessment

Keywords: esophageal cancer respiratory muscle strength pulmonary function testing functional exercise capacity