Kornimate/medical-research-clean huggingface dataset:
prospective genotyping for total hip or knee replacement patients receiving warfarin (coumadin)

Conditions: Venous Thromboembolism; Bleeding

Summary: several human genes affect how medications are metabolized by the body. it is believed that knowledge of variations of these genes can help health care providers better manage an anticoagulation medicine called warfarin (coumadin®)and as a result decrease patient problems with bleeding or the development of blood clots. this study was designed to evaluate if genetic testing can improve warfarin initiation better than usual care.

this study was completed in 2008 and was published. consult the citation link for more details.

Eligibility criteria:
inclusion criteria: * participants were otherwise healthy adults (≥ 18 years of age) who were planning total hip or knee replacement or revision surgery at the university of utah hospital, and scheduled a pre-operative office visit at the university of utah orthopaedic center. exclusion criteria: * blood transfusion in previous two weeks * participant is already taking warfarin * pre-operative inr \> 4.0 * pre-operative bilirubin \> 2.4 mg/dl * current active cancer diagnosis with ongoing treatment * concomitant medications known to exert a major interaction with warfarin such as septra, metronidazole, tramadol, amiodarone, ciprofloxacin, or cimetidine.

Keywords: genotyping warfarin dosing arthroplasty
proteomic analysis of patients undergoing bariatric surgery

Conditions: Obesity; Colon Cancer; Thyroid Cancer; Esophageal Cancer; Pancreatic Cancer; Gastric Cancer; Potmenopausal Breast Cancer; Endometrial Cancer; Liver Cancer; Gallbladder Cancer; Prostate Cancer; Ovarian; Kidney Cancer; Multiple Myeloma; Meningioma; Breast Cancer; Ovarian Cancer

Summary: the expression of proteins in the blood of obese individuals is different from the expression of proteins in healthy individuals, and is also different in individuals after bariatric surgery. therefore, this research aims to better understand protein expression in patients indicated for surgical treatment of obesity, evaluating the pre-operative and post-operative status. the objective of this research is to better understand protein expression in patients indicated for surgical treatment of obesity, evaluating the pre-operative and post-surgery status.

the objective of this study is to analyze the proteomics of obese patients in the preoperative context of bariatric surgery to evaluate which are the up-regulated proteins - potentially related to oncogenic metabolic pathways - and also the down-regulated proteins in the context of obesity - potentially protective in the context of cancer. as well as, evaluate the variation of these proteins, as well as the metabolic pathways with which they are associated, after weight loss promoted by bariatric surgery, in the period of 01 year after this intervention. the proteomic study will be carried out based on the formation of pools organized based on the patients' pre- and postoperative similarities. proteomic analyzes will be carried out on a high-performance liquid chromatography system (nanouplc) model acquity mclass, waters. coupled to a quadrupole mass spectrometer-time of flight (qtof) model sunapt xs, waters. finally, the raw data (raw mass spectra) will be analyzed by the progenesis qi software (waters) to identify the proteins.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age with a bmi above 35 kg/m² associated with comorbidity or bmi above 40 kg/m² without comorbidities, exclusion criteria: * patients with a previous history of cancer; * underage patients * patients with other diseases predisposing to the development of cancer: cirrhosis, ulcerative colitis, barrett's esophagus, etc. * patients who have previously undergone bariatric surgery;

Keywords: obesity cancer bariatric surgery proteomics biomarkers mass spectrometry
stripes study: study to reduce infection post cesarean section

Conditions: Chlorhexidine Gluconate Cloths; Infection; Cesarean Section; Infectious Morbidity; Surgical Site Infections; Endometritis

Summary: the objective of this study is to determine if the use of chlorhexidine gluconate cloths prior to cesarean section reduce the rate of infectious morbidity (i.e. surgical site infections, endometritis). the study will be offered to women who present for a scheduled primary or repeat cesarean section at mount sinai medical center. the eligible women will be randomized to use of a 2% chlorhexidine gluconate (chg) cloth or placebo cloth (a fragrance free cleansing cloth) the night before and the morning of their scheduled procedure. participants will be blinded to the arm in which they have been assigned. this study intends to show that the use of 2% chg cloths prior to cesarean section will reduce the rate of surgical site infections.

chlorhexidine is a sterile, germ-free solution, which is regularly used to clean the skin immediately before surgery and works by killing or preventing the growth or spread of bacteria. data exists in both the orthopedic and cardiac literature to show that an additional preoperative use of chlorhexidine further reduces the risk of post procedure infections. limited data exists regarding the use of a preoperative use of chlorhexidine in patients undergoing obstetric or gynecologic procedures and there is no wash or cloth used prior to cesarean section as a standard of care. the hope for this study is to identify if an additional preoperative chlorhexidine wash will further decrease or prevent infection in women who deliver their babies via cesarean section. all patients with a scheduled cesarean section surgery will be approached for enrollment during their pre-admission testing visit on the labor floor 2 days before the scheduled cesarean section, a visit that is standard procedure for this surgery. once a patient is consented, she will be randomly assigned to one of the 2 arms of the study: the eligible women will be randomized to use of 2% chlorhexidine gluconate (chg) cloths or placebo cloths (a fragrance free cleansing cloths) on the body the night before and the morning of their scheduled procedure. participants will be blinded to the arm in which they have been assigned. the purpose of this study is to determine if the use of 2% chlorhexidine gluconate cloths prior to cesarean section reduces the rate of surgical site wound infection and/or postpartum endometritis, which is an infection or inflammation of the endometrium (the inner lining of the uterus).

Eligibility criteria:
inclusion criteria: * women * \> 24 weeks gestation * scheduled for a primary or repeat cesarean section exclusion criteria: * allergy to chlorhexidine * unplanned or emergency cesarean section

Keywords: cesarean section chlorhexidine gluconate chg surgical site infection obstetrics infection prevention pregnancy
study to assess real life effectiveness of foslevodopa/foscarbidopa in adult german participants at initial stages of advanced parkinson's disease (early-fos)

Conditions: Parkinson's Disease

Summary: parkinson's disease (pd) is a neurological condition, which affects the brain. pd gets worse over time, but how quickly it progresses varies a lot from person to person. some symptoms of pd are tremors, stiffness, and slowness of movement. this study will assess how effective foscarbidopa/ foslevodopa is in treating german adult participants at initial stages of advanced parkinson's disease under routine clinical practice. foslevodopa/foscarbidopa is an approved drug for the treatment of parkinson's disease. approximately 125 adult participants who are prescribed foslevodopa/foscarbidopa by their doctors will be enrolled across approximately 20 sites in germany. participants will receive foslevodopa/foscarbidopa subcutaneous infusion as prescribed by their physician. participants will be followed for up to 12 months. there is expected to be no additional burden for participants in this trial. participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.


Eligibility criteria:
inclusion criteria: * participants with a diagnosis of levodopa-responsive idiopathic parkinson's disease * eligibility for foscarbidopa/foslevodopa (ldp/cdp) therapy in accordance with the approved local label * participant must be an adult male or female, 18-64 years of age * time since beginning of motor fluctuations ≤ 3 years * the hoehn and yahr (h\&y) stage \< 3 in the on-medication condition * decision to treat with ldp/cdp made by the clinician prior to any decision to approach the participant to participate in this study exclusion criteria: * previous exposure to any device-aided therapy (dat). * any condition included in the contraindications section of the approved local ldp/cdp label. * participants with mini mental state examination (mmse) score \< 24

Keywords: parkinson's disease foscarbidopa/foslevodopa
the use of bioelectrical stimulation in the treatment of post-prostatectomy erectile dysfunction

Conditions: Erectile Dysfunction Following Radical Prostatectomy

Summary: erectile dysfunction (ed) affects up to 20% of men and is a growing problem with advancing age. there are many causes that contribute to ed, including the concomitant use of prescription drugs for health problems, including hypertension, or diseases such as diabetes. causes an up-regulation or increased local tissue expression of these proteins. this study follows the demonstration of the effectiveness of using bes in the treatment of ed. the aim of this study will be to examine the potentially additive effect of adding a third arm to the previous protocol to include the addition of 4 new target proteins to vegf, including endothelial nitric oxide (enos), stromal-derived factor 1 (sdf-1), insulin-like growth factor (igf) and follistatin.

for this randomized clinical trial, 10 patients from a private urology clinic will be selected. each patient will serve as their own two-month documentation control using the validated iief-5 and ehs questionnaires. the intervention period will last 8 weeks. and 6 months of follow-up after the end of treatment to see how long the benefit lasts without continued treatment. the assessment will be carried out before the intervention period (pre-intervention) and after the intervention period (post-intervention and follow-up) for all participants. all patients who, after medical consultation, are diagnosed with erectile dysfunction and who meet the inclusion criteria will be included in the study. erectile function will be assessed using the validated questionnaire iief-5. the instrument will be completed by a blind researcher and the technique will be applied by a physiotherapist trained in the area. erectile dysfunction (ed) was defined as the inability to achieve and/or maintain sufficient penile erection for satisfactory sexual performance 11 for at least 6 months, accompanied by an iief5 questionnaire score of less than 22 points. the patients were in the supine position, in a lithotomy position. they will undergo trichotomy at the site of placement of the self-adhesive surface electrodes. each patient will have their own pair of electrodes that will be used until the end of therapy, and they will be discarded after the end of the sessions. the intervention will consist of the application of low intensity transcutaneous penile electrical stimulation for 45 minutes using frequency.

Eligibility criteria:
inclusion criteria: male patient, aged 40 to 75 years, with a stable marital relationship (6 months) diagnosis of post-prostatectomy erectile dysfunction (iief5 score less than 22) exclusion criteria: neurogenic ed (spinal injury, parkinson, ms) hypogonadism (total testosterone \ 200 and/or glycated hemoglobin\>8%) decompensated systemic arterial hypertension (sbp \> 160 and/or dbp \>100 morbid obesity use of vacuum device smokers diagnosis of coronary artery disease and/or cerebrovascular disease impossibility of understanding the objectives, study technique and informed consent cognitive deficit
construction of a multi-center clinical research collaboration network for children with congenital heart disease in china

Conditions: Congenital Heart Disease (CHD)

Summary: this project intends to unite the representatives of typical congenital heart disease hospitals in various provinces and cities across the country to jointly establish a multi-center clinical research collaboration network for children with congenital heart disease in china, establish a platform and mechanism for the collection and sharing of data on children with congenital heart disease in china, and create a real-world public database of children with congenital heart disease in china that benchmarks the international level, so as to provide a solid data foundation for high-quality research on children with congenital heart disease in china.


Eligibility criteria:
inclusion criteria: 1. age 0-18 years, regardless of gender; 2. patients diagnosed with congenital heart disease confirmed by cardiac ultrasound examination; exclusion criteria: none

Keywords: congenital heart disease (chd) database
acute kidney injury in patients with acute respiratory distress syndrome

Conditions: Acute Kidney Injury; Acute Respiratory Distress Syndrome

Summary: several studies suggested that ards may have important adverse effects on renal function, but few studies have specifically addressed the risk factors of aki and its impact on the outcome in theses patients.

acute respiratory distress syndrome is considered an acute diffuse lung injury in which an inciting inflammatory event is followed by hypoxemic respiratory failure. despite advances in the management of ards, the mortality remains high. the lung safe study reported that hospital mortality was 34.9% in patients with mild ards, 40.3% in patients with moderate ards, and 46.1% in patients with severe ards. understanding the prognostic factors in ards is essential for decreasing its mortality. acute kidney injury (aki) is a common and challenging medical condition in critically ill patients, in which there is a sudden renal impairment during hours to days and it is known to be associated with increased mortality .other adverse outcomes associated with aki includes chronic kidney disease (ckd) and high cardio-vascular complications. the incidence of aki in hospitalized adults was reported to be 22% with a mortality rate of 24%. the severity of aki ranges from stage 1 to stage 3 according to the kdigo (kidney disease: improving global outcomes) system, based on decreased urine output over time, or increases in serum creatinine, or both.

Eligibility criteria:
inclusion criteria: * adult patients (≥18 years old) * diagnosis of ards according to berlin definition exclusion criteria: * patients with preexisting chronic kidney disease * aki prior to the onset of ards
corrected left ventricular electrical delay predicting response to cardiac resynchronization therapy

Conditions: Chronic Heart Failure; Cardiac Resynchronization Therapy

Summary: cardiac resynchronization therapy (crt) is a well-established treatment for patients with severe systolic heart failure (hf) and ventricular desynchronization. despite the consistently observed structural and functional improvements as well as reductions in hf events and mortality in large multicenter randomized trials, 30% patients remain classified as nonresponders. present evidences showed that qrs duration was the most effective parameter to predict responsivity of crt in patients with severe hf. but some studies showed that qrs duration could be influenced by obesity and gender. accordingly, the simple qrs interval width of body surface electrocardiograph should not be the most satisfactory parameter for screening patients suitable for crt. recent study showed that left ventricular electrical delay, as measured by the time from the onset of qrs to the lv electrogram peak (qlv), predicted crt response. at long qlv intervals, atrioventricular optimization (avo) can increase the likelihood of structural response to crt. however, it is unclear whether it is suitable for chinese patients. the investigators would like to validate this relation in a chinese population and explore if a corrected qlv might do better to predict the responsivity of crt.


Eligibility criteria:
inclusion criteria: * •more than 18 years * informed consent signed * nyha class ≥ ii, an ejection fraction of ≤ 0.35, qrs duration of ≥ 150 milliseconds with non-lbbb) or ≥ 120 milliseconds with lbbb, who treated with crt * the estimated survival time was more than one year * sinus rhythm, pacemaker independent exclusion criteria: * •nyha class i symptoms * severe liver or kidney dysfunction * valvular heart disease * pregnancy or lactation women * percutaneous coronary intervention (pci) or cardiac artery bypass graft (cabg) within 3 month * have malignant tumors and the estimated survival time was less than one year * an enzyme-positive myocardial infarction within 3 months before enrollment, or atrial fibrillation * any reasons cannot complete follow-up; or researchers think that don't suit to be included in the research of other conditions
pilot study of percutaneous correction of hallux valgus

Conditions: Hallux Valgus

Summary: this is a pilot study with a randomized controlled design.


Eligibility criteria:
inclusion criteria: * patients of both sexes with adult hallux valgus with indication for corrective surgical treatment * hva (hallux valgus angle): 20°-40° * ima (intermetatarsal angle): 10°-20° exclusion criteria: * patients with instability of the first metatarsophalangeal joint * patients with severe morphostructural alterations or other pathologies in the foot and lower limb * patients requiring additional surgical procedures * patients with severe vascular and neurological systemic pathologies * systemic pathologies that may impair bone consolidation
an integrated intervention to reduce secondhandsmoke in children

Conditions: Secondhand Exposure; Smoking Status

Summary: this is a community essay to assess the effectiveness of a multi-level (individual, family, and school) school-based intervention to prevent the exposure to secondhand smoke (shs) in a population of 1,734 schoolchildren (12-14 years old) in terrassa (catalonia, spain). schools were assigned to the intervention or the controlgroup at random. the investigators assessed shs exposure in different settings (at school, at home, on transportation and leisure time) and tobacco consumption by means of a questionnaire before and one year after the intervention. based on a previously evaluated intervention to prevent smoking initiation (pase/esfa program) the investigators designed a new intervention (the respir•net program) including two new activities to prevent passive smoking to be applied at three levels: in the classroom (pupils), at the school (pupils, teachers, and parents), and in the family (pupils and parents).


Eligibility criteria:
inclusion criteria: * all schoolchildren attending the school at the day of interview exclusion criteria: * absence of school * language problems with questionnaire

Keywords: tobacco smoke pollution tobacco use
endoscopic resection of papillary adenomas; a novel treatment algorithm to prevent recurrence - a pilot-study (erase-pilot)

Conditions: Papillary Adenoma

Summary: recurrence after endoscopic papillectomy is described in up to 33% of the cases (range 12-33%). this leads to re-interventions, a cumulative risk of adverse events, and the need for long-term follow-up. recurrences most likely originate from either the biliary orifice or lateral resection margins. ablative methods such as radiofrequency ablation (rfa) and thermal ablation by cystotome inside the bile duct have been described to treat intraductal extension of which the use of a cystotome seems to have a more favorable safety profile. however, no studies focusing on the preventive use of these ablative methods in patient with papillary adenomas have been performed. it is hypothesized that the curative resection rate can be increased and recurrence prevented by using a combination of snare tip soft coagulation (stsc) of the resection margins and thermal ablation by cystotome of the biliary orifice in patients with and without the suggestion of intraductal extension. therefore, aim of this study is to assess the safety and feasibility of endoscopic papillectomy combined with thermal ablation of the biliary orifice by cystotome and stsc of the lateral resection margins.


Eligibility criteria:
inclusion criteria: * papillary adenoma which seems suitable for curative endoscopic resection. * 18 years or older. * capable of providing written and oral informed consent. exclusion criteria: * patients with intraductal extension of \>1 cm beyond the duodenal wall or adenocarcinoma will be excluded since surgical resection is considered the preferred treatment in these cases. * failure to place a pd stent in patients with normal pancreatic duct anatomy. * refusal to provide informed consent.

Keywords: endoscopic papillectomy recurrence stsc intraductal ablation cystotome
effect of curodont repair in patients with early approximal carious lesions

Conditions: Dental Caries

Summary: the purpose of this study is to evaluate the therapeutic benefit of curodont repair for the treatment of early approximal carious lesions compared to no treatment.

all study participants must have two early approximal carious lesions in need of a treatment but not of an invasive treatment (split-mouth design). one lesion will be treated with curodont repair and the other will not undergo a treatment as control. study duration is 12 months. for assessment x-ray pictures are used.

Eligibility criteria:
inclusion criteria: * two approximal carious lesions on different teeth with at least one tooth in between * both study lesions must not require an invasive treatment * size and form of the lesions: the lesions must be fully visible and assessable on radiographs * the two carious lesions must fall into classes: d1 (outer half of enamel) d2 (inner half of enamel) d3 (outer part of dentine) but only if very little dentine is involved (enamel-dentine junction) * able and willing to observe good oral hygiene throughout the study * age ≥ 18 years and ≤ 65 years * willing and able to attend the on-study visits * willing and able to understand all study-related procedures * written informed consent before participation in the study exclusion criteria: * the two study test lesions are located on adjacent teeth * fluoride varnish application \< 3 months prior to study treatment * tooth with numerous carious lesions * evidence of tooth erosion * history of head and neck illnesses (e.g. head/neck cancer) * any pathology or concomitant medication affecting salivary flow or dry mouth * any metabolic disorders affecting bone turnover * patient suffers from diabetes * concurrent participation in another clinical trial * women who are breast-feeding, pregnant or who plan a pregnancy during the study * women of childbearing potential who declare being unwilling or unable to practice contraception such as hormonal contraceptives, sexual abstinence or intercourse with a vasectomised partner

Keywords: dental caries curodont repair p11-4
complications: urgent c section vs elective c section

Conditions: Urgent Caesarian Section Secondary to Cord Prolapse

Summary: the medical literature does not provide sufficient information or recommendation regarding specific antibiotic coverage for urgent caesarian sections. the goal of this study is to compare maternal and neonatal morbidity of women who have undergone urgent caesarian sections for prolapsed cord to those who have undergone elective caesarian sections in order to develop a standard treatment protocol. the medical record review will include many parameters including complications, type of antibiotic usage etc.


Eligibility criteria:
inclusion criteria: * women undergoing urgent caesarian section for prolapsed cord. * women undergoing elective caesarian section. exclusion criteria: * preterm birth * multiple gestation

Keywords: prophylaxis antibiotics maternal complications neonatal complications cord prolapse elective caesarian section maternal morbidity neonatal morbidity