Kornimate/medical-research-clean huggingface dataset:
dhacm in lumbar decompression and microdiscectomy surgery

Conditions: Scarring; Spinal Stenosis; Herniated Disc

Summary: prospective evaluation of the safety and efficacy of dhacm on clinical outcomes in lumbar laminectomy and microdiscectomy patients as assessed by oswestry disability index.

the objective of this prospective study is to evaluate the safety and efficacy of dhacm on clinical outcomes in lumbar laminectomy and microdiscectomy patients randomized to one of two groups: 1) without dhacm (control) or 2) dhacm.

Eligibility criteria:
inclusion criteria: 1. are 18 (eighteen) years of age or older at the time of surgery. 2. patients with single- or multi-level spinal stenosis undergoing open lumbar laminectomy, or patients with single-level herniated nucleus pulposus undergoing single-level lumbar microdiscectomy 3. are willing and able to return for the scheduled follow-up visits, follow post operative instructions and undergo the required radiographic exams for up to 5 time points between 4 weeks and 24 months post-surgery (6 weeks ± 2 weeks, 12 weeks ± 2 weeks, 6 months ±1 month, 1 year±2 months, and 2 years ±2 months post-surgery), including one study mri-scan at 12 weeks ±2 weeks for the first 20 patients enrolled. 4. are willing and able to sign study specific informed consent. exclusion criteria: 1. non-english speaking patients 2. non-surgical candidate defined as any patient deemed by the surgeon not to be a surgical candidate cannot participate for the following reasons: that patient does not meet indications for lumbar laminectomy or microdiscectomy surgery, patient has a contraindication to surgery such as medical comorbidities, pregnancy, etc. 3. allergic to aminoglycoside antibiotics 4. is a prisoner 5. is involved in worker's compensation or other litigation relative to the spine injury 6. has a history of drug or alcohol abuse within the last 12 months 7. is currently participating in another drug or device clinical trial 8. previous spinal surgery 9. history of deformity, mechanical instability, or spinal fusion requirement 10. history of hard- or soft-tissue spinal infection 11. has signs or symptoms of any disease, such as autoimmune disease, which could result in allograft failure, or has experienced allograft failure in the past 12. patients unable to undergo a mri
the incidence, clinical characteristics and outcome of infective endocarditis among intravenous drug abusers versus non-drug abusers.

Conditions: Infective Endocarditis

Summary: we aim to describe the incidence of ivda among patients presented with ie, describe their clinical, psychiatric and microbiological characteristics in comparison to non - ivda, as well as the rate and types of complications and outcome, and responsiveness to medical treatment or surgical intervention.

infective endocarditis (ie) is the infection of the endocardial surface of the heart mainly affecting the valves of the heart. it is still associated with very high morbidity and mortality all over the world despite various advances in diagnostic and treatment methods. a few studies have shown that infective endocarditis represents less than 0.5% of adult cardiovascular admissions.while the overall incidence of ie has remained stable over the last several years, ie has increased in young people in parallel with injection drug use (idu) behaviours and the growing opioid crisis. according to recent guidelines , intravenous (iv) drug use is considered a minor duke criteria for the diagnosis of infective endocarditis. compared to the general population, intravenous drug abuse (ivda) is associated with an up to 100-fold increased risk of ie through several mechanisms, including endothelial injury from injected particulate matter, direct injection of contaminated material, and drug-associated vasospasm leading to intimal damage and thrombus formation. also, ivda is associated with hiv outbreaks, which is a well-known risk factor for ie. hiv-associated ie is associated with high rates of morbidity and mortality than non-hiv-associated ie.because of its pathophysiology, ivda-associated ie is more commonly right-sided. beyond these known characteristics, however, literature on this topic is substantially limited, including the clinical and microbiological characteristics of these patients, rate and types of complications and outcomes.

Eligibility criteria:
inclusion criteria: * adult patients (\>18 years) with definite or possible ie. exclusion criteria: * patients with rejected diagnosis of infective endocarditis after workup, according to modified duke's criteria.
novel lung functional imaging for personalized radiotherapy

Conditions: Lung Cancer

Summary: the primary objective of this study is to assess the safety and feasibility of personalized radiotherapy with four-dimensional (4d) computed tomography (ct)-based pulmonary ventilation imaging, which selectively avoids irradiating highly-functional lung regions.

in this clinical trial, the investigators will assess the safety and feasibility of 4d ct ventilation image-guided personalized radiotherapy. the investigators will deliver personalized radiotherapy treatments that selectively avoid irradiating highly-functional lung regions for lung cancer patients, and follow up patients to assess the safety and feasibility. the primary hypothesis to be tested is: 4d ct ventilation image-guided personalized radiotherapy can be delivered safely for lung cancer.

Eligibility criteria:
inclusion criteria: * primary lung cancer or metastatic disease to the lungs to be treated with either conventionally-fractionated radiotherapy (cfrt) or hypo-fractionated stereotactic ablative radiotherapy (sabr). * age restriction and/or gender/ethnic restrictions: patients must be ≥18 years of age. there are no gender or ethnic restrictions. * concurrent chemotherapy is allowed, but not required. * life expectancy with treatment should be ≥6 months in the estimation of the treating physicians. * zubrod performance status ≤2 * adequate marrow and hepatic function defined as hgb ≥8; platelets ≥100k; anc≥1500; lfts ≤2x upper limit of normal and creatinine ≤1.3 or creatinine clearance of ≥50 * patient must be able to provide study specific informed consent prior to study entry. exclusion criteria: * prior radiotherapy for thoracic cancer or other malignancy leading to any overlap of planned radiotherapy fields. * for patients undergoing definitive cfrt, patients with distant metastatic disease are not eligible. * for patients undergoing sabr, both early stage primary lung cancer patients and those with limited metastatic disease to the lungs are eligible; however, patients with oligometastatic disease should have a controlled primary and no more than one other involved organ system. * children (\<18 years of age), pregnant women, university of california employees or students, or prisoners will be excluded from this study.

Keywords: radiotherapy pulmonary functional imaging computed tomography (ct) image registration functional image-guided radiotherapy
take the pressure off, nyc!

Conditions: Hypertension

Summary: briefly, a trained barbershop navigator will work with each barbershop to measure blood pressure on each adult customer who agrees, and to provide culturally-targeted education about high blood pressure and its consequences, and motivational interviewing-informed counseling about therapeutic lifestyle changes. for customers found to have high blood pressure, the navigator will also provide referral and navigation to a medical provider and, as appropriate, a local pharmacy.

this program will be patterned after barbershop-based blood pressure programs that have demonstrated efficacy in achieving lower blood pressure and improved hypertension control rates among black men with high blood pressure. this program will reach 10-12 barbershops per year, working with 2-3 barbershops each quarter. briefly, a trained barbershop navigator will work with each barbershop t o measure blood pressure on each adult customer who agrees, and to provide culturally-targeted education about high blood pressure and its consequences, and motivational interviewing-informed counseling about therapeutic lifestyle changes. for customers found to have high blood pressure, the navigator will also provide referral and navigation to a medical provider and, as appropriate, a local pharmacy. at all recruitment events, all study team members and potential participants must wear masks and practice social distancing when appropriate. participants who do not have face masks should be offered masks for continued outreach participation. study team members will also wear gloves and have hand sanitizer visible. when available, staff should wash hands frequently with soap and water. if this option is not available, staff should frequently use hand sanitizer.

Eligibility criteria:
inclusion criteria: * participants must be age 18 years or older * self-identified as a black or african american male * have uncontrolled hypertension defined as sbp\>135 mmhg or dbp\>85 mmhg and sbp \>130 mmhg or dbp \>80 mmhg (in those with diabetes) at the screening exclusion criteria: * under the age of 18 * does not consent to participate
audio data collection for identification and classification of coughing

Conditions: COVID-19; Coronavirus Infections; Hay Fever; Asthma; Chronic Obstructive Pulmonary Disease; Influenza; Common Cold; Respiratory Tract Infections; Healthy

Summary: an open access study that will define and collect digital measures of coughing in multiple populations and public spaces using various means of audio data collection.


Eligibility criteria:
inclusion criteria: cohort 1, 3, 4 and 5: * females and males over 18 years old * willing to share demographic data with the sponsor of the study * willing to follow app use instructions during the course of the study * willing to complete survey instruments as described in study procedures * willing to provide electronic informed consent * able to read and understand the english language well enough to complete electronic informed consent cohort 2: any person present in the vicinity of a healthmode cough monitoring device exclusion criteria: no exclusion criteria -
a study to evaluate the safety and efficacy of pac-14028 cream in rosacea

Conditions: Rosacea

Summary: this clinical study is to determine the optimum dose of pac-14028 cream in a therapeutic confirmatory clinical study by evaluating the safety and therapeutic equivalence of pac-14028 cream 0.1%, 0.3% and 1.0% in patients with rosacea.


Eligibility criteria:
inclusion criteria: * male and female patients aged 19 - 70 years old * among the patients diagnosed with erythematotelangiectatic and papulopustular rosacea in accordance with the diagnostic criteria of the national rosacea society expert committee * subjects with rosacea scored 2 or more according to the investigator global assessment (iga) at screening exclusion criteria: * those who can't be diagnosed or assessed for rosacea due to the presence of trauma, tattoo, scar, excessive hairs on the facial region * those who have received a facial laser treatment within 6 weeks * those who have been administered with oral retinoid or therapeutic vitamin a within 6 months * those who have received a hormonal treatment such as estrogen within 3 months * those who have been administered with systemic antibiotics or systemic steroid formulation within 4 weeks * those who have been administered with local retinoid, local steroid and local antibiotics and local medication for the treatment of rosacea on face within 4 weeks * those who have a history of blood disorder that can have a serious effect on the clinical study * women who are pregnant, lactating or who plan to be pregnant during the clinical study period or women of childbearing potential who do not use available contraceptive methods
nutritional supplementation in adults with chronic respiratory disease

Conditions: Malnutrition; Pulmonary Disease, Chronic Obstructive; Other Pulmonary Disease, Chronic Obstructive

Summary: the purpose of this study is to determine whether nutritional support with a complete formula is effective to improve malnutrition and respiratory function in patients with chronic pulmonary disease compared to the standard hospital dietary advise.

this is a unicenter, controlled, randomized, prospective, parallel-group, open-label study to evaluate the effect of a nutritional formula on nutritional status, pulmonary function and quality of life. adult patients will be randomized to receive the nutritional formula or to follow the standard hospital' dietetic recommendations during 12 weeks.

Eligibility criteria:
inclusion criteria: * patients aged between 18 and 80 years. * patient from clínica san gabriel or clínica san pablo surco, inpatient or outpatient. * patients with chronic pulmonary disease (including bronchiectasis, tuberculosis specific sequel, fibrothorax, diffuse interstitial lung disease, copd). * patients presenting one or more of the following situations of malnutrition or nutritional risk: bmi \ 10% in the past 6 months; unintentional weight loss \>5% in last moth; ffmi \<15 kg/m2 (women) or \<16 kg/m2 (men). * patients who signed informed consent. exclusion criteria: * clinically unstable patients. * patients requiring other nutritional supplements or parenteral nutrition. * patients diagnosed with active pulmonary tuberculosis. * patients with acute respiratory failure. * patients with immunosuppression (including hiv, diabetes or neoplasms).

Keywords: malnutrition dietary supplement nutritional supplement complete enteral formula copd
treatment of nonunion of limb fracture with human amniotic epithelial cells（haecs）

Conditions: Nonunion Fracture

Summary: the purpose of this study is to evaluate the efficacy and safety of human amniotic epithelial cells transplant in nonunion of limb fracture patients.

in this study, patients of nonunion after limb fracture will be treated with human amniotic epithelial cells. clinical and radiological assessment is performed. haecs developing from the epiblast as early as 8 days after fertilization, recent data reported indicate that haecs possess proper osteogenic differentiation potential and a localized modulatory influence on the early tissue remodeling process, making these cells a promising stem cell source for bone regeneration after fractures.

Eligibility criteria:
inclusion criteria: * diagnosed with nonunion of limbs by x-ray and bone scan; * compliance to treatment and long term follow-up; * be able and willing to participate in the study; * written informed consent before study. exclusion criteria: * pregnant or breastfeeding; * patients with malignancy, immunocompromised ( hiv aids, diabetes mellitus, active hepatitis), in a immunosuppressant therapy ( chemotherapy or steroids), or health status, mental diseases, which will influence the study; * patients undergoing any other treatment that are not related to this study; * others considered not appropriate selected patients.

Keywords: nonunion fracture of limb
traumatic brain injury and alzheimer's disease/related dementias caregiver support intervention

Conditions: Caregiver Burden; Caregiver Stress Syndrome; Caregiver Burnout

Summary: the tbi-ad/adrd caregiver support intervention (tacsi) incorporates psychosocial and psychoeducational approaches with the objective of: a) identifying stressors associated with caregiving for family members who have the dual diagnosis of traumatic brain injury and dementia; and b) supporting caregivers in developing more effective coping and communication strategies as well as enhanced caregiving self-efficacy.


Eligibility criteria:
inclusion criteria: * the care recipient has a physician diagnosis of tbi and ad/adrd (i.e., those with a diagnosis of both tbi and progressive cognitive decline) * the caregiver self-identifies as someone who provides the most help/is most responsible for the person with tbi-ad/adrd because of their cognitive impairments (or shares the role equally with another caregiver) * the caregiver indicates a willingness to participate in the tacsi evaluation * the caregiver is english speaking * the caregiver is 21 years of age or older * the caregiver is not currently participating in any other type of service that provides one-to-one psychosocial consultation or caregiver coaching (peer mentorship/support group participation/general counseling not specific to caregiving is not a deterrent to enrollment) at the discretion of the umn research team * the caregiver resides in the us. exclusion criteria: * caregivers who have a new or worsening mental health condition and are not receiving ongoing treatment. when applicable, if caregivers have not remained on a stable psychotropic medications dosage, such as antidepressants, anxiolytics or anti-psychotics, for the prior three months they will be excluded.

Keywords: caregiver traumatic brain injury alzheimer's dementia
the long non coding malat1 as a potential salivary diagnostic biomarker in oral squamous cell carcinoma through targeting mi rna 124

Conditions: Oral Squamous Cell Carcinoma

Summary: objective: is to determine the diagnostic accuracy of lncrna malat1 as a potential salivary biomarker of oscc as well as assessment of the salivary expression level of mirna 124 which is targeted by malat1. materials and methods: saliva samples were collected for the quantitative determination of salivary "malat1 and mi rna -124" using quantitative real-time polymerase chain reaction technique for the two study groups, group a: 20 patients with a diagnosis suggestive of oscc and group b: 20 age-and-sex-matched healthy individuals, as normal controls.

materials and methods: saliva samples were collected for the quantitative determination of salivary "malat1 and mi rna -124" using quantitative real-time polymerase chain reaction technique for the two study groups, group a: 20 patients with a diagnosis suggestive of oscc and group b: 20 age-and-sex-matched healthy individuals, as normal controls.

Eligibility criteria:
inclusion criteria: * the study included patients with oscc and healthy controls of both sexes. exclusion criteria: * patients having systemic diseases such as; liver diseases, cardiovascular disease, nervous system, pulmonary, renal, endocrine, gastrointestinal disorders, or other types of cancer were excluded.

Keywords: long non coding rna, oral squamous cell carcinoma, micro rna, salivary biomarkers, malat1, oral cancer biomarkers
video hit in sudden sensorineural hearing loss

Conditions: Sudden Sensorineural Hearing Loss

Summary: the function of the vestibular system among patients with sudden sensori neural hearing loss will be evaluted using the video head impulse test


Eligibility criteria:
inclusion criteria: * patients hospitalized with the diagnosis of sudden sensorineural hearing loss exclusion criteria: * vertigo * other etiology causing dizziness * neurological dysfunction othe than the hearing loss * difficulty performing the vhit * chronic vestibular disorder * pregnant women
acupuncture to treat insulin resistance in women with and without polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome; Insulin Resistance

Summary: the central hypothesis is that acupuncture break the vicious circle of androgen excess and reverse insulin resistance and improve health related quality of life and affective symptoms in overweight and obese women with and without polycystic ovary syndrome.

polycystic ovary syndrome (pcos) is the most common endocrine and metabolic disorder in women. the main metabolic phenotype is hyperinsulinemia and insulin resistance, which are independent of body weight and worsen hyperandrogenism and ovulatory dysfunction. pharmacological treatments are symptom oriented and usually effective but have metabolic and gastrointestinal side effects. therefore, it is important to evaluate new nonpharmacological treatment strategies, as most women with pcos require long-term treatment. hypothesis and aims our central hypothesis is that acupuncture break the vicious circle of androgen excess and reverse insulin resistance and improve health related quality of life and affective symptoms in overweight and obese women with and without pcos. the specific aim are designed to test the hypotheses that 1. acupuncture (acute and chronic i.e. 5 weeks treatment, 3 times per week) improves insulin sensitivity in overweight and obese women with and without pcos 2. acupuncture (acute and chronic i.e. 5 weeks treatment, 3 times per week) regulate key signaling molecules and mitochondrial oxidation/biogenesis in skeletal muscle and adipose tissue in overweight and obese women with and without pcos 3. acupuncture (chronic i.e. 5 weeks treatment, 3 times per week) improve health related quality of life and symptoms of anxiety and depression in overweight and obese women with and without pcos time frame of the study is 5-6 weeks. no long term follow up.

Eligibility criteria:
inclusion criteria: * bmi \> 25 to \< 35 and * clinical signs of hyperandrogenism (hirsutism or acne) and * at least one of the following two signs; oligo/amenorrhea and/or ultrasound-verified polycystic ovaries controls should have bmi \> 25 to \< 35, regular cycles with 28 days ± 2 days, no signs of hyperandrogenism. exclusion criteria: exclusion criteria for all women 1. age \> 38 years 2. exclusion of other endocrine disorders such as hyperprolactinemia (s-prolactin \< 27µg/l), nonclassic congenital adrenal hyperplasia (17-hydroxyprogesterone \< 3nmol/l), and androgen secreting tumors. 3. autoimmune disorders, cancer, type i diabetes and type 2 diabetes. 4. pharmacological treatment (cortisone, antidepressant, antidiabetic, hormonal contraceptives, hormonal ovulation induction or other drugs judged by discretion of investigator) within 12 wks accounts for all participants. 5. blood pressure \>160 / 100 mmhg 6. pregnancy or breastfeeding the last 6 months 7. acupuncture last 2 months 8. language barrier or disabled person with reduced ability to understand information.

Keywords: pcos insulin resistance acupuncture
impact of suppressing surgical stress reaction on postoperative inflammation.

Conditions: Inflammation; Postoperative Pain

Summary: patients undergoing surgery under opioid free general anesthesia (ofa) are monitored with antinociceptive devices like nol or ani that measures sympathetic activity but are invisible for the attending anesthesiologist . observational study comparing patients with sufficient suppression of sympathetic reactions with patients having insufficient suppression on hemodynamic stability, post operative sedation, pain and inflammatory markers.

all patients get an opioid free anesthesia using dexmedetomidine, lidocaine, ketamine and magnesium. dosing is according to the attending anesthesiologist. total dose of each drug and duration of anesthesia are recorded. antinociceptive devices measures how long the patient is during anesthesia having a nociceptive level nociception level index (nol) or analgesia nociception index (ani) above normal without showing the data to the attending anesthesiologist. relationship is calculated between on one side the hemodynamic stability, postoperative sedation, pain, postoperative crp and on the other side the time nol is above 20 or ani is below 50.

Eligibility criteria:
inclusion criteria: * major surgical procedures without need for regional anesthesia exclusion criteria: * allergy to one of the anesthetics used * major liver, renal cardiac or pulmonary disease reducing normal function