Kornimate/medical-research-clean huggingface dataset:
iowa produce prescription program

Conditions: Diabetes Mellitus Type 2; Pre-diabetes

Summary: the goal of this study is to understand how a produce prescription program paired with a behavioral nutrition intervention affect nutrition and overall health in low-income iowans with type 2 diabetes or pre-diabetes. research questions include: 1. what impact does a produce prescription program paired with a behavioral nutrition intervention on nutrition security compared to the behavioral nutrition intervention alone and usual care groups? 2. what impact does a produce prescription program paired with a behavioral nutrition intervention on hemoglobin a1c, fruit and vegetables intake, food security, and related behaviors compared to the behavioral nutrition intervention alone and usual care groups? participants of the behavioral nutrition intervention (produce your path) alone will: * watch monthly nutrition education videos about topics like planning and budgeting for groceries, reading nutrition labels, eating more fruits and vegetables, and new recipes to try * complete a short quiz about their own goals and habits related to the topic * (optional): join a facebook group to communicate with other participants about their goals, share ideas and recipes, and ask questions participants of both the produce prescription and produce your path interventions will: * complete each monthly nutrition education module and monthly quiz * (optional): join a facebook group to communicate with other participants about their goals, share ideas and recipes, and ask questions * receive $30.00 per each person in their household monthly to buy fresh fruits and vegetables participants of the control group will: * follow their usual care for health conditions * complete the required data collection for the study


Eligibility criteria:
inclusion criteria: * age 18 and older * pre-diabetic or diabetic diagnosis by medical provider; * receiving medical assistance under a state plan (medicaid) or eligible for supplemental nutrition assistance program (snap) benefits; * owns a smart phone; * able to read and understand english; speaks english; * patient at a partnering health care clinic; * no one else in the household is enrolled in i-ppp exclusion criteria: * under 18 years old; * not pre-diabetic or diabetic (as diagnosed by medical provider); * does not receive medical assistance under a state plan (medicaid) or is not eligible for snap benefits; * does not own a smart phone; * cannot read or understand english; * does not speak english; * is not a patient at a partnering health care clinic; * others in household participating in i-ppp

Keywords: produce prescription behavioral nutrition intervention online nutrition education self determination theory
the energy cost of 1-hour football training

Conditions: Energy Expenditure; Body Composition; Resting Metabolic Rate; Overweight and Obesity

Summary: this study aims at investigating the energy expenditure following a single football trainning session in middle aged males. the participants will perform a soccer training session \[a single training session including 60 minutes of warm up, soccer technical exercises and small-sided game\] and a cotrol trial (no intervention included, only daily measurements) in randomized, repeated measures, crossover design.

football is an intermittent sport with frequent activity changes and a high number of explosive movements. as a result, both mitochondrial and the non-mitochondrial energy sources (phosphagens, lactic acid system) are heavily utilized during football practice and games, which may contribute to the rise of oxygen consumption following exercise (epoc) compared with cardiovascular-type exercise, where vo2 can reach a steady state.however, it is observed that there is a methodological limitation in the determination of total energy expenditure during and after football training and specifically in overwight middle-aged participans with metabolic syndrome. twenty overweight middle-aged males with mtabolic syndrome will perform a soccer training session \[a single training session including 60 minutes of warm up, soccer technical exercises and small-sided game\] and a cotrol trial (no intervention included, only daily measurements) in randomized, repeated measures, crossover design. anthropometric, biochmeistry indicators, metabolic, blood pressure, physical activity and performance measurements will be measured at baseline. global positoning system and accelerometry devices will be used to measure the distance and intensity of football trianing. the metabolic cost will be estimated from heart rate, blood lactate, resting oxygen uptake, exercise oxygen uptake, and excess post-exercise oxygen consumption measurements using a portable gas analyzer.

Eligibility criteria:
inclusion criteria: * free of musculoskeletal injuries * no use of ergogenic supplements or medication * free of chronic diseases * age of 40-60 years * bmi\>25 * metabolic syndrome exclusion criteria: * musculoskeletal injury * use of alcohol, caffeine and any type of ergogenic supplements or medication during the course of the study

Keywords: football training energy expenditure oxygen consumption blood lactate metabolic syndrome
investigating distress tolerance in adults with tourette syndrome

Conditions: Tourette Syndrome; Tic Disorders; Tics

Summary: although behavior therapy is recognized as a first-line intervention for tourette's disorder (td), less than 40% of adults with td respond to this evidence-based treatment. limited tolerance for aversive premonitory urges and affective states that accompany tics may be one likely factor that impedes behavior therapy outcomes. this study examines the relationship between distress tolerance and tic inhibition among adults with td, and investigates the mechanism and effect of therapeutic skills training to enhance distress tolerance abilities. findings will determine the optimal approach to enhance distress tolerance among adults with td and ultimately lead to better behavior therapy outcomes.

tourette's disorder and other persistent tic disorders collectively affect about about 1% of the population, cause significant distress, and functional impairment. although behavior therapy is recognized as a first-line intervention for tourette's disorder (td), less than 40% of adults with td respond to this evidence-based treatment. limited tolerance for aversive premonitory urges and affective states that accompany tics may be one likely factor that impedes behavior therapy outcomes. this study examines the relationship between distress tolerance and tic inhibition among adults with td, and investigates the mechanism and effect of therapeutic skills training to enhance distress tolerance abilities.

Eligibility criteria:
participants will be eligible for participation if the following inclusion criteria are met: * at least 18 years of age * have moderate tic severity or greater as evidenced by a ygtss total tic score greater than 14 (\>9 for adults with motor or vocal tics only) * exhibit a tic frequency of at least one visible tic per minute * be fluent in english * have a total premonitory urge for tics scale (puts) total score greater than 17 at visit 2 * have a total dts score greater than 30 at visit 2 exclusion criteria for participants include: * history of cardiovascular disorder * history of fainting or seizures * history of frostbite * open cut or sore on hand to be immersed * fracture to the limb to be immersed * history of reynaud's phenomenon * inability to complete rating scales * inability to attend study visits

Keywords: tourette syndrome distress tolerance premonitory urge tic disorders distress tolerance skill training
mastoid obliteration using s53p4 bioactive glass versus mastoidectomy alone for chronic suppurative otitis media

Conditions: Chronic Suppurative Otitis Media

Summary: chronic suppurative otitis media (csom) is characterized by intermittent or continuous otorrhea lasting for longer than 6 weeks. most cases can be treated conservatively using antibiotic drops and oral antibiotics. however, some cases will not respond to conservative treatment and demonstrate persistant discharge. in these cases, especially if a ct-scan shows opacification of the mastoid air cells, a mastoidectomy can be considered as treatment modality. in recent years, obliteration of the mastoid cavity following mastoidectomy is gaining popularity. however, the effectiveness of obliterating the mastoid in comparison to mastoidectomy alone is uncertain for csom. in this retrospective cohort study, our aim is to compare mastoidectomy to mastoidectomy + mastoid obliteration in a cohort of patients suffering from csom with mastoid involvement. the hypothesis is that obliterating the mastoid cavity will result in a higher frequency of dry ears and in a lower frequency of revision surgeries.


Eligibility criteria:
inclusion criteria: * suffering from csom, as indicated by otorrhea as main complaint preoperatively * at least one year of follow-up, in order to asses the primary outcome * opacification of the mastoid air cells on preoperative ct-scans, as indication for mastoid involvement * canal wall up or canal wall down mastoidectomy * operated between 2010 and 2022 exclusion criteria: * patients suffering from middle ear cholesteatoma
early detection of atrial fibrillation using mobile technology in cryptogenic stroke patients

Conditions: Cryptogenic Stroke; Atrial Fibrillation

Summary: the purpose of this study is to demonstrate the added value of mobile health (mhealth) to detect atrial fibrillation (af) early in the care path of cryptogenic stroke and transient ischemic attack (tia) patients.

the use of photoplethysmography (ppg)-based mhealth (with smartphone and smartwatch) is compared to the guideline-recommended insertable loop recorders (ilr) in the detection of af in cryptogenic stroke or tia patients.

Eligibility criteria:
inclusion criteria: * diagnosis of cryptogenic ischemic stroke or tia * the patient or its legal representative is willing to sign the informed consent exclusion criteria: * history of af or atrial flutter * life expectancy of less than one year * not qualified for ilr insertion * indication or contraindication for permanent oral anticoagulants (oac) at enrolment * untreated hyperthyroidism * myocardial infarction or coronary bypass grafting less than one month before the stroke onset * presence of patent foramen ovale (pfo) and it is or was an indication to start oac according to the european stroke organization guidelines * inclusion in another clinical trial that will affect the objectives of this study * not able to understand the dutch language * patient or partner not in possession of a smartphone

Keywords: mobile health prolonged cardiac monitoring photoplethysmography
trial of aripiprazole in the treatment of cd in adolescents

Conditions: Conduct Disorder

Summary: the proposed study will be a 6-week open label study evaluating aripiprazole in the treatment of 12 male post-pubertal adolescents (13-17 years, tanner stage 4) diagnosed with conduct disorder. the initial dose depending on the weight of the patient will be as follows: \ 70 kg = 10 mg/d (data on file, 2003, bristol-myers squibb). for the first two weeks of the study, the dose will be flexible based on response and tolerance and thereafter will remain fixed.

the use of atypical antipsychotics in children began in 1992 with several small case series with clozapine. since that time, five other atypical agents, risperidone, olanzapine, quetiapine, ziprasidone and aripiprazole have been introduced into the us market. the newer atypical agents are not associated with agranulocytosis that has limited the usefulness of clozapine. among the atypical antipsychotics, risperidone has remained the most extensively studied in children and adolescents, for a variety of problems, including tourette's disorder, conduct disorder, schizophrenia, aggression, and pervasive development disorder. risperidone has been shown to be an effective treatment in many of these disorders. however, weight gain, hyperprolactinemia, and extrapyramidal symptoms (eps) are troublesome adverse effects more commonly associated with risperidone such that the drug's utility in this aged patient population is limited. we expect that the utility of aripiprazole in treating the pediatric population will not be limited by adverse effects like the other atypical antipsychotics.

Eligibility criteria:
inclusion criteria: * male post-pubertal adolescents (13-17 years, tanner stage 4) diagnosed with conduct disorder. exclusion criteria: * clinically significant laboratory and/or ecg abnormalities * pre-existing health conditions that would compromise patient safety * mental retardation * previous use of aripiprazole * active psychosis

Keywords: aripiprazole
genotropin treatment in short prepubertal children with intra-uterine growth retardation

Conditions: Growth Disorders; Intrauterine Growth Retardation

Summary: to evaluate the effect of continuous and intermittent administration of genotonorm on stature in short prepubertal children with intra-uterine growth retardation


Eligibility criteria:
inclusion criteria: * chronological age (ca) between 3 and 10 for girls * chronological age between 3 and 12 for boys * height for ca below - 2 sd * birth length for ca below -2sd exclusion criteria: * endocrine disease except well-substituted hypothyroidism * sever chronic disease * skeletal dysplasia * known chromosomal aberration * ongoing treatment with steroids * known intrauterine infection

Keywords: short height intra-uterine growth retardation genotonorm continuous treatment intermittent treatment
major depression and inflammatory risk markers for coronary heart disease

Conditions: Depression

Summary: the overall purpose of this research is to examine whether depression influences immune system function. studies indicate that individuals who are depressed experience coronary heart disease at a higher rate than expected. this study's goal is to begin identifying mechanisms that might be responsible for this process. this research also examines whether behavioral processes (e.g. smoking) or hormonal processes (e.g. adrenaline release) are responsible for immune system differences between depressed and nondepressed people

to qualify for participation, subjects are to be between the ages of 18-55, medically healthy and free of all medication three months prior to enrollment. half of them will be clinically depressed; the remaining one half will be healthy controls without a history of psychiatric illness. all subjects who qualify for the study will attend two laboratory sessions. during the first visit, participants will undergo a structured psychological interview, complete questionnaires about their mood, personality, and behavior, and have blood drawn to assess their immune system function. during the second visit, participants will complete additional questionnaires about their mood, personality, and behavior. the subjects will also participate in a mock job interview to look at their body's response to stress. before and after the interview, the subjects will have blood drawn and be asked to collect saliva samples to assess their immune system function. in addition to the two laboratory visits, participants will be asked to collect additional information while going about their normal activities. in order to accomplish this, they will be given a small hand held portable computer. four times each day for four days, the computer will signal them to collect a saliva sample. this will be used later to measure hormone levels. this study will explore changes in the immune system and metabolic system that might predispose depressed individuals to develop heart disease

Eligibility criteria:
for eligibility, potential subjects will be 18-55 years of age, free of all medication during the past three months, and have no history of chronic illness involving the cardiovascular, endocrine, immune systems
feasibility of allogeneic stem cell transplantation in higher-risk-mds (acrobat)

Conditions: High-risk MDS

Summary: open-label, randomized multicenter phase iii non-inferiority study

open-label, randomized, prospective multicenter phase iii study to compare the role of hmt followed by hsct vs hsct upfront in hr-mds with \ 10% bm blasts in terms of feasibility of hsct (non-inferiority trial).

Eligibility criteria:
inclusion criteria: 1. patients with newly diagnosed higher-risk mds, including ipss intermediate-2 and high, and ipss-r intermediate to very-high 2. age 18-70 years 3. previously untreated for hr-mds 4. hsct - eligible 5. life expectancy ≥3 months; 6. signed written informed consent according to ich/eu/gcp and national local laws 7. eastern cooperative oncology group performance status grade of 0-2 exclusion criteria: 1. acute myeloid leukaemia with \>20% blasts in bm or peripheral blood (pb); 2. concurrent malignancy diagnosed in the past 12 months (with the exception of skin basalioma); 3. severe renal, cardiac, liver or lung impairment; 4. pregnant or lactating or potentially fertile (both males and females), who have not agreed to avoid pregnancy during the trial period; women of childbearing potential and men must agree to use effective contraception during and up to 3 months after treatment with azacitidine. 5. hiv infection; active, uncontrolled hcv or hbv infections or liver cirrhosis; 6. clinically relevant neurological or psychiatric diseases; 7. hypersensitivity (known or suspected) to aza; 8. prior treatments: 1. prior investigational drugs (within 30 days); 2. radiotherapy, chemotherapy, or cytotoxic therapy for non-mds conditions within the previous 6 months; 3. growth factors (epo, g-csf or gm-csf) during the previous 21 days; 4. androgenic hormones during the previous 14 days; 5. prior transplantation or cytotoxic therapy, including azacitidine, aza or chemotherapy, administered to treat mds (a previous treatment with lenalidomide is admitted, provided that lenalidomide had been stopped at least 60 days before enrolment).

Keywords: mds transplant azacitidine
an intervention to improve adolescent headache self-management

Conditions: Pain; Headache

Summary: the purpose of this study is to test the efficacy of a new app to help adolescents with chronic or reoccurring headaches self manage pain.

headaches dramatically affect adolescents' overall functioning and quality of life. we have developed a highly engaging mobile-based program that will help adolescents to make connections between behaviors and symptoms, and to ultimately improve functioning and quality of life. the mobile-based program will provide a state of the art pain tracker, a variety of coping strategies, and information about self-management of symptoms. this app will offer a maximally engaging way to help adolescents track their pain, make connections between lifestyle and pain, and learn key self-management skills. the study involves the participant being randomized into either the experimental group, where he/she will be using this mobile application to track their headache symptoms, or the control group, where he/she will receive headache treatment as usual; the control group will not be using an app for this study. the intervention will last for two months. participants will be assessed at baseline, at 2-months post baseline, at 3-months post baseline, and at 6-months post baseline. all participants will be asked to complete online questionnaires about their headaches. we plan to enroll 144 adolescent participants with headaches, as well as one caregiver (meaning a parent/guardian) for each adolescent.

Eligibility criteria:
\[the above age limits are specific to adolescent participants.\] inclusion criteria - adolescents * between ages 13 and 17 (inclusive) * able to read and speak english * has recurring headaches that are not related to another medical condition * iphone user with access to an iphone \[4/4s or later\] for use during the intervention period exclusion criteria - adolescents * secondary headache or seizure disorder. examples include: increased intracranial pressure, hydrocephalus, traumatic brain injury, benign or cancerous brain * cognitive impairment or psychiatric condition that would interfere with ability to use the mobile application or complete the assessments inclusion criteria - caregivers parent or guardian of an adolescent who meets the above eligibility criteria for adolescent participants

Keywords: self management app headache adolescent
transvaginal notes sleeve gastrectomy

Conditions: Obesity

Summary: this is a prospective chart review/data collection study of natural orifice translumenal endoscopic surgery (notes) for sleeve gastrectomy, that will include questionnaires administered throughout the study. subjects enrolled will be those intending to have a transvaginal notes sleeve gastrectomy. data will be collected and reviewed through 12 months post-op.


Eligibility criteria:
inclusion: 1. diagnosis of morbid obesity bmi \> 40 2. female, age 18-75 3. mentally competent to give informed consent 4. scheduled to undergo a transvaginal notes sleeve gastrectomy exclusion: 1. pregnant women 2. bmi \< 40

Keywords: obesity sleeve gastrectomy transvaginal notes
randomized controlled eight-week study of the safety and efficacy of the lung flute

Conditions: COPD

Summary: this is an eight-week, randomized, controlled, two arm parallel study. the study consists of, a screening visit, two weeks of intervention-free run-in randomization, clinic visits week 0, 1, 2, 4, 6, and 8 weeks during the intervention period to collect 24 hour sputum and to confirm techniques of device use and entries into daily diaries. twenty-four (24) hour sputum samples will be collected and weighed at each clinic visit. in addition to clinic visits, subjects will be expected to make daily diary entries of copd symptoms. clinical evaluation will include adverse event surveillance, and st. georges respiratory questionnaire.

no further details

Eligibility criteria:
inclusion criteria: * age of over 40 with copd exclusion criteria: * children, * new mothers; and * women intending to become pregnant

Keywords: copd