Kornimate/medical-research-clean huggingface dataset:
a comparison of single versus double evacuation for treatment of hydatidiform mole

Conditions: Hydatidiform Mole

Summary: hydatidiform mole is a common complication of pregnancy with an incidence of 1in 400 pregnancies in india. although this is a benign condition , it is having the malignant potential too. a repeat curettage after evacuation of hydatidiform mole was generally advocated till 1990s. a thorough curettage at the time of initial evacuation was not performed because of larger size of uterus and risk of perforation. subsequently a number of studies assessed the usefulness of repeat curettage and found it was unnecessary and not cost effective . however all these studies are retrospective in design and conducted in developed countries where hydatidiform mole is diagnosed earlier because of wider use of ultrasonography. thus there is a need to perform a well designed prospective study to compare the effectiveness of single evacuation with double evacuation in treatment of hydatidiform mole for prevention of gestational trophoblastic neoplasia.this study compares the effectiveness of single evacuation versus double evacuation for treatment of hydatidiform mole for prevention of gestational trophoblastic neoplasia .


Eligibility criteria:
inclusion criteria: * ultrasound confirmed complete mole exclusion criteria: * partial mole * history of treatment for molar pregnancy like prior evacuation or chemotherapy * women requiring hysterectomy for treatment of h mole

Keywords: hydatidiform mole molar pregnancy h mole gtn gtd
post-market evaluation of the evo icl

Conditions: Myopia; Myopic Astigmatism

Summary: the objective of this study is to assess the rate of early intraocular pressure (iop) increases following implantation of evo/evo+ implantable collamer lens (icl).

this study will be conducted at up to 10 sites in the us, by surgeons qualified by experience and training to implant the evo/evo+ lens.

Eligibility criteria:
inclusion criteria: * moderate to high myopia correctable with available evo icl powers. * moderate to high myopic with astigmatism correctable with available evo icl powers. * stable refractive history within 0.50 d cylinder for 1 year prior to implantation. * stable refractive history within 0.50 d for spherical equivalent 1 year prior to implantation. * able and willing to return for scheduled follow-up examinations after surgery. * able to read, understand and provide written informed consent on the institutional review board (irb) approved informed consent form (icf) and provide authorization as appropriate for local privacy regulations. * other protocol-specified inclusion criteria may apply. exclusion criteria: * ocular hypertension or glaucoma. * insulin dependent diabetes or diabetic retinopathy. * history of previous ocular surgery. * monocular. * pregnant or nursing women, or those who plan to become pregnant over the course of this clinical study or has another condition with associated fluctuation of hormones that could lead to refractive changes. * other protocol-specified exclusion criteria may apply.

Keywords: nearsightedness phakic iol toric icl icl ticl evo astigmatism
acute myocardial infarction in cancer patients

Conditions: Acute Myocardial Infarction; Cancer

Summary: using national health insurance service database, current study aim to evaluate the risk and prognosis of acute myocardial infarction in cancer patients and to find the optimal treatment strategy for acute myocardial infarction that can improve long-term prognosis.

this study will be conducted using korean national health insurance service database. patients who were diagnosed with cancer from 2002 to 2021 will be included in the study. using the selected patients, current study will analyze the incidence and prognosis of acute myocardial infarction in cancer patients and the prognosis according to the treatment method for acute myocardial infarction will be compared. primary outcome will be all-cause death. secondary outcomes will be myocardial infarction, revascularization, hospitalization for heart failure, stroke, and clinically relevant bleeding.

Eligibility criteria:
inclusion criteria: * patients diagnosed with cancer between 2002 and 2021 * patients who were diagnosed with acute myocardial infarction after cancer diagnosis exclusion criteria: * patients who died during period of cancer diagnosis

Keywords: acute myocardial infarction cancer incidence prognosis
school-based assessment of micronutrient interventions in adolescents (samia) in zanzibar

Conditions: Anemia

Summary: this purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status and school performance/attendance among in-school adolescents in zanzibar, tanzania.

this study aims to implement and evaluate micronutrient supplementation interventions to improve adolescent nutrition, health and education in zanzibar. findings from this study will clarify the optimal supplementation strategy (iron and folic acid alone or adding other essential nutrients) and provide a basis for scale up of national micronutrient supplementation programs to benefit the adolescent population as a whole in zanzibar. this will be a cluster randomized study with 3 arms. at the beginning of the academic year, 42 schools will be enrolled (14 schools per arm) to receive either 1) supplementation with weekly iron and folic acid (ifa); 2) supplementation with daily multiple micronutrient supplements (mms) (including iron and folic acid as components); or 3) to serve as controls. students in intervention schools will receive supplementation and students in control schools will receive the usual care (which does not include supplementation but does include existing curriculum on nutrition and water, sanitation and hygiene \[wash\]). the program will be evaluated at the end of year 1, comparing effects of weekly ifa and daily mms on anemia status and school attendance/performance. the more effective strategy (mms or ifa) will be scaled up to all the study schools for year 2 of the intervention, and the outcomes will be re-assessed.

Eligibility criteria:
inclusion criteria: * adolescents aged 10-17 years * enrolled in secondary school form 1 at study initiation * member of one of the selected classes in a participating school * consent provided by the parent * assent provided by the adolescent * fluency in swahili and/or english exclusion criteria: * no informed consent from parent or assent from adolescent * self-reported pregnancy

Keywords: anemia multiple micronutrient supplementation (mms) iron and folic acid (ifa) nutrition adolescent health
exogenous toxicants and genetic susceptibility in als

Conditions: Amyotrophic Lateral Sclerosis

Summary: amyotrophic lateral sclerosis (als), also known as lou gehrig's disease, is a fatal neurodegenerative disease that poses a significant burden for affected individuals and their family members. the principal objective of this epidemiologic study is to identify environmental and genetic risk factors for als. of primary interest is whether environmental chemicals such as heavy metals, pesticides and organic solvents contribute to the cause of als. we also aim to identify genetic factors that contribute to the risk of als because individuals with certain genetic traits may be unable to protect against the toxic effects of chemical exposure. other factors that may protect against the development of als, such as dietary antioxidants, are also under investigation. if modifiable factors affecting the risk for als could be identified, interventions to delay or even prevent the development of als could be developed.

the principal objective of this study is to identify environmental and/or genetic risk factors for amyotrophic lateral sclerosis (als). we are addressing this objective by conducting a case-control study of als in the northern california kaiser permanente medical care program (kpmcp). over a four-year period, approximately 175 persons newly diagnosed with als will be identified and recruited through physician referrals and computerized mechanisms available within the kaiser system. the patients with als will be compared to a sample of 350 age- and gender-matched persons without als from the same membership. specific study aims are as follows: (1) to investigate the association of als with exposure to neurotoxicants including lead, other heavy metals, solvents and pesticides; (2) to determine whether inadequate oxidative defenses for protecting against free-radicals enhance the toxicity of exogenous exposures; (3) to examine the evidence for familial aggregation of neurodegenerative diseases among first-degree relatives of patients with als; and (4) to estimate the incidence of als in diverse racial and ethnic groups.

Eligibility criteria:
individuals with als within the kaiser permanente population of northern california, ages 18 years and older, with first diagnosis of als in the years 1996-2000. controls are individuals who are age- and sex-matched to the patients with als, also from the kaiser permanente population.
comparison of two surgical techniques to treat knock knees in children

Conditions: Genu Valgus

Summary: knock knees or genu valgus necessitates in some children corrective surgery with partial closure of the growth plate at level of the knee.

background: genu valgus is a condition with malalignment of the lower extremity. surgery may be indicated in severe cases and reversible hemiepiphysiodesis is often the treatment of choice in growing children. partial closure can be obtained by stapling technique or with a new treatment called tension band plating.

Eligibility criteria:
inclusion criteria: * genu valgus * remaining growth exclusion criteria: * systemic disease * unilateral disease

Keywords: hemiepiphysiodesis
school based health promotion program in secondary schools

Conditions: Obesity; Cardiovascular Risk

Summary: the purpose of the study is to determine whether a school based health promotion program in secondary schools is effective with respect to an increase of physical activity, physical fitness and health.

current understanding of physical activity in childhood demonstrates the health benefits of regular exercise, such as improved cardiovascular fitness, skeletal health and prevention of overweight and obesity. the children obtained weekly health education lessons from their teachers to increase the physical activity in and outside of school and to improve health behavior (healthy food, no drugs) as well as the general well-being of children. monthly training for teachers and regular training (2-3x/year) for the parents complete the intervention.

Eligibility criteria:
inclusion criteria: * children in the 1. grade of secondary general schools or intermediate schools with written consent from the parents in the greater munich area exclusion criteria: * children without written consent from their parents

Keywords: obesity childhood and adolescence school and family-based lifestyle intervention cardiovascular risk obesity and associated cardiovascular risk in childhood and adolescence, health behaviour
tens effectiveness and knee osteoarthritis in humans

Conditions: Knee Osteoarthritis

Summary: tens is a non pharmacological intervention to control pain. both high (\>50 hz) and low (\<10 hz) frequency tens are used in the clinic and it is thought that each type works through different mechanisms (see for review sluka and walsh, 2003). hyperalgesia, an increased response to a noxious stimuli, is one component of pain and occurs both at the site of injury, primary hyperalgesia, and outside the site of injury, secondary hyperalgesia. recent studies in animals with arthritis of the knee show that low and high frequency tens differentially modulate primary and secondary hyperalgesia. therefore the investigators hypothesize that tens will reduce hyperalgesia and pain with movement resulting in increased function.

the following specific aims will address this hypothesis: specific aim 1 will compare the effect of high frequency tens, low frequency tens, and placebo tens in patients with osteoarthritis on a variety of outcome measures: primary and secondary hyperalgesia, subjective pain scores, and function. specific aim 2 will determine the relationships among these multiple pain measures in people with osteoarthritis, and compare to age matched controls. specific aim 3 will determine the genetic variability as it relates to osteoarthritis pain and response to tens treatment specific aim 4 will determine how body composition (bmi, fat mass, percent fat, lean mass, and bone mass) impacts the effectiveness of tens one of the long-term goals of the investigators is to determine the clinical effectiveness of non-pharmacological treatments for pain, like tens. these studies will begin to address this issue by examining effects of tens on a variety of outcome measures in patients with a specific controlled condition (i.e., knee osteoarthritis). this research is innovative because it will be the first to systematically examine the effects of tens on a variety of physiological parameters (primary and secondary hyperalgesia) and clinical outcome measures (resting pain, movement-evoked pain, function) in a common, painful and limiting condition that is frequently seen in physical therapy clinics. these studies will further allow us to translate basic science experiments previously performed in animal models of arthritis to the clinic. this information is expected to assist the clinician in the treatment choice for a particular patient and guide future clinical research.

Eligibility criteria:
inclusion criteria: * diagnosis of medial compartment knee osteoarthritis * 18 and 60 years of age * being able to ambulate to the mail box and back * stable medication schedule over the last three weeks * pain rating \> 3 on a 0-10 scale when verbally asked to rate knee pain in the weight bearing position * normal l1-s2 dermatomal screen and normal great toe and thumb proprioception. exclusion criteria: * knee surgery in the last six months * knee injection in the last four weeks * serious medical condition, uncontrolled diabetes mellitus, hypertension * dementia or cognitive impairment * permanent lower extremity sensory * prior tens use

Keywords: knee oa tens
comparison of facet oscillatory mobilization and mobilization with movement in chronic mechanical neck pain

Conditions: Chronic Mechanical Neck Pain

Summary: the study compares facet oscillatory mobilization and mobilization with movement in managing chronic mechanical neck pain, aiming to determine the effectiveness of these techniques in pain, range of motion, and disability.

this study will be conducted as a randomized controlled trial, it will include 32 participants divided into two groups receiving different mobilization techniques along with conventional physical therapy. outcome measures such as the numeric pain rating scale (nprs), neck disability index (ndi), and inclinometer will be used to assess changes over a two-week intervention period with a follow-up after one month.

Eligibility criteria:
inclusion criteria: * complaint of chronic mechanical neck pain ( more than 6 weeks). * neck disability index (ndi) score more than 16% * age between 35-45 years, both male and female * nprs score more than 3-6. * recurrent neck pain aggravated at least once in the month. * painful cervical rom (flexion less than 80, extension less than 70, rotation less than 90 to both sides and lateral flexion less than 35 degree. exclusion criteria: * cervical radiculopathy * cervical canal stenosis * severe neurological disorder * previous cervical surgery * recent history of fall/trauma to the cervical spine.

Keywords: chronic mechanical neck pain facet oscillatory mobilization mobilization with movement (mwm)
abatacept in the treatment of uveitis

Conditions: Uveitis

Summary: the purpose of this study is to assess the safety and efficacy of abatacept in the treatment of uveitis.


Eligibility criteria:
inclusion criteria: * patients with vision-threatening autoimmune uveitis * failure to respond to prednisone and at least one other systemic immunosuppressive, or intolerance to such medications due to side effects exclusion criteria: * serious concomitant illness that could interfere with the subject's participation
understanding the role of large extracellular vesicles in lymphomas and lymphoproliferative disorders: the "off the beaten track" liquid biopsy

Conditions: Diffuse Large B-Cell Lymphoma; Follicular Lymphoma; Marginal Zone Lymphoma(MZL); Mycosis Fungoides; Chronic Lymphocytic Leukemia; Hairy Cell Leukemia (HCL); T Cell Lymphoma; Multiple Mieloma

Summary: this study aims to investigate the role of extracellular vesicles as diagnosic and prognostic biomarkers in patients with lymphomas or lymphoproliferative disorders. in particular, circulating extracellular vesicles, thanks to their cargo of proteins, lipids, and nucleic acids, play a role in the communication between cells. since it has been described that these vesicles are able to influence also immune cells, the study of their functions may lead to the discovery of new mechanisms underlying this type of diseases.

it is a 3-year monocentric in vitro study on human tissue. 50 patients with aggressive and indolent non-hodgkin lymphomas (diffuse large b-cell lymphoma (dlbcl; group a; n=10), follicular lymphoma (fl; group b; n=10), marginal zone lymphoma (mzl; group c; n=10), peripheral t-cell lymphoma (ptcl; group d; n=10), mycosis fungoides (mf; group e; n=10)), and patients with chronic lymphocytic leukaemia (cll; n=10; group f; n=10), hairy cell leukemia (hcl; group g; n=10), and multiple myeloma (mm; n=10; group h; n=10) will be enrolled over a period of 24 months. follow-up: 12 months. patients will be enrolled at the complex operative unit of haematology-irccs azienda ospedaliero-universitaria di bologna. the peripheral blood samples of patients (40 ml) will be collected only at diagnosis within normal clinical practice, outside of clinical study protocols, and following the treatment guidelines in use at the centre. the analysis of the samples will be performed at the unità operativa complessa di ematologia-irccs azienda ospedaliero-universitaria di bologna in collaboration with the istituto romagnolo per lo studio dei tumori 'dino amadori' - irst irccs and with the university of perugia.

Eligibility criteria:
inclusion criteria for patients: * age ≥ 18 years. * patients with who 2017-defined diagnosis of indolent and aggressive non-hodgkin lymphoma (specifically diffuse large b-cell lymphoma, follicular lymphoma, marginal zone lymphoma, peripheral t-cell lymphoma, mycosis fungoides) or chronic lymphocytic leukemia or hairy cell leukemia or multiple myeloma. * signed informed consent. exclusion criteria for patients: - concomitant secondary neoplasia. inclusion criteria for healthy donors: * age ≥ 18 years. * signed informed consent. exclusion criteria for healthy donors: - healthy donors with neoplasia.
phase ii safety study of vemurafenib followed by ipilimumab in subjects with v600 braf mutated advanced melanoma

Conditions: Melanoma

Summary: the purpose of this study is to assess the safety profile of vemurafenib, 960 mg, administered for 6 weeks, followed by ipilimumab monotherapy in patients with braf v600 mutated advanced/metastatic melanoma.


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com key inclusion criteria: * men and women 18 years of age and older * histologic diagnosis of malignant melanoma tested positive for the braf v600 mutation * previously untreated unresectable stage iii or stage iv melanoma * complete set of brain/neck, chest, abdomen/pelvis axial radiographs taken within 28 days of first dose of study drug * measurable melanoma by physical or radiographic examination * brain metastases stable after radiation for at least 1 month and off corticosteroid therapy for ≥30 days prior to enrollment * eastern cooperative oncology group performance status of 0 or 1 * adequate hematologic parameters and renal and hepatic function key exclusion criteria: * primary ocular melanoma * active brain metastases with symptoms or requiring corticosteroid treatment * any other malignancy from which the patient has been disease-free for less than 2 years, with the exception of adequately treated and cured basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix * history of or current active autoimmune diseases, including but not limited to inflammatory bowel diseases, rheumatoid arthritis, autoimmune thyroiditis, autoimmune hepatitis, systemic sclerosis, systemic lupus erythematosus, autoimmune vasculitis, autoimmune neuropathies * history of or current immunodeficiency disease, splenectomy, or splenic irradiation * prior anticancer therapy or investigational products \<4 weeks prior to enrollment * prior therapy with a braf or mek inhibitor and prior investigational anticancer immunotherapies; * prior therapies with immunosuppressive agents within the past 2 years * concomitant therapy with any anticancer or potent immunosuppressive agent, surgery, radiotherapy, other investigational anticancer therapies, or chronic use of systemic corticosteroids