Kornimate/medical-research-clean huggingface dataset:
changes in body adiposity by dual probiotic strains positively correlated with changes in lp-pla2 activity in overweight adults

Conditions: Overweight

Summary: the objective was to evaluate the effect of the consumption of dual probiotic strains containing lactobacillus curvatus (l. curvatus) hy7601 and lactobacillus plantarum (l. plantarum) ky1032 on weight loss, body adiposity and inflammatory markers including lipoprotein-associated phospholipase a2 (lp-pla2) activity in overweight subjects.

a randomized, double-blind, placebo-controlled study was conducted on 120 subjects with age between 20 and 65 years, nondiabetic (fasting blood glucose \<126 mg/dl and 2-hour blood glucose \<200 mg/dl), and overweight (25 kg/m2 ≤ body mass index (bmi) \< 30 kg/m2). over a 12 week test period, the probiotic group consumed 2 g of powder twice a day containing l. curvatus hy7601 and l. plantarum ky1032, while the placebo group consumed the same product without probiotics for 12 weeks.

Eligibility criteria:
inclusion criteria: * age between 20 and 65 years * nondiabetic (fasting blood glucose \<126 mg/dl and 2-hour blood glucose \<200 mg/dl) * overweight (25 kg/m2 ≤ body mass index (bmi) \< 30 kg/m2) exclusion criteria: * constant consumption of any probiotics products within 1 month before screening * unstable body weight (body weight change \> 1 kg within 3 months before screening) * hypertension * type 2 diabetes * cardiovascular disease * cerebrovascular disease * thyroid disease * dietary supplementation within 6 months before screening * pregnancy or breast-feeding * medication affecting body weight, energy expenditure, glucose control or antibiotic treatment within 3 months before screening * acute or chronic infections * liver disease * kidney disease * gastrointestinal disease * cancer * medication or alcohol abuse * any other acute or chronic disease requiring treatment

Keywords: probiotic weight loss lp-pla2
to evaluate the effect of reveratrol,folic acid, vitamin d, vitamin b12 and b6 in male infertility

Conditions: Male Infertility

Summary: the objective of this study is to evaluate the impact of the genante(tm) on the spermiogram parameters in infertile male patients

this is a single-centre prospective observational study. twenty infertile male patients. inclusion criteria are: age:18-50 years oligozoospermia: \< 5 million spermatozoa/ml; asthenozoospermia: \< 32% progressive motile spermatozoa; teratozoospermia: \< 4% normal forms. esclusion criteria: patients with azoospermia, who smoke, use drugs, drugs with proven fertility toxicity, exposed to any environmental or occupational toxic substances, radiation or heat; with orchitis secondary to mumps, sexually transmitted diseases, history of cryptorchidism, previous testicular torsion, genitourinary anomalies, alterations of the epididymis or deferens; and inguinal surgery pretreatment evaluation included: semen analysis hormonal determinations:follicle-stimulating hormone (fsh) and luteinising hormone (lh) total testosterone total,estradiol, prolactina, 25-oh-vitamin d3); scrotal ultrasound prostatic transrectal ultrasound outocmes measures (baseline, at 1 and 6 months): * semen volume (ml) * total sperm number (106/ejaculate) * sperm concentration (106/ml) * total motility (pr + np) * progressive motility (pr, %) * vitality (live spermatozoa, %) * sperm morphology (normal forms, %) * ph * fsh * lh * testosterone totale * estradiol * prolactiona * 25-oh-vitamin d3 * scrotal ultrasound * prostatic transrectal ultrasound

Eligibility criteria:
inclusion criteria: * male 18-50 years * oligozoospermia: \< 5 million spermatozoa/ml; * asthenozoospermia: \< 32% progressive motile spermatozoa; * teratozoospermia: \< 4% normal forms. exclusion criteria: * azoospermia * smoke * use drugs * use drugs with proven fertility toxicity * exposition to any environmental or occupational toxic substances * exposition to radiation or heat * orchitis secondary to mumps * sexually transmitted diseases * history of cryptorchidism * previous testicular torsion * genitourinary anomalies * alterations of the epididymis or deferens * inguinal surgery

Keywords: male infertility reveratrol vitamin b12 vitamin b6 folic acid
a study of ro4917523 in patients with fragile x syndrome

Conditions: Fragile X Syndrome

Summary: this multi-center, randomized, double-blind, placebo-controlled, parallel-group study will investigate the efficacy and safety of ro4917523 in adolescent and adult patients with fragile x syndrome. patients will be randomized to receive oral doses of 0.5 mg or 1.5 mg of ro4917523, or matching placebo once daily. the anticipated time on study treatment is 12 weeks.


Eligibility criteria:
inclusion criteria: * adult and adolescent patients, 14-50 years of age * diagnosis of fragile x syndrome with a confirmed fragile x mental retardation 1 (fmr1) full mutation and qualifying scores on the aberrant behavior checklist (abc) and cgi-s * patients must agree to either remain completely abstinent or to use two effective contraceptive methods during and 3 weeks after the study exclusion criteria: * previous treatment with another metabotropic glutamate (mglu) receptor antagonist within 18 months or with ro4917523 * participation in a clinical trial involving an investigational (unapproved) drug within 3 months or 5 times the half-life (whichever is longer) before start of this study * any uncontrolled, unstable clinically significant psychiatric condition other than fragile x syndrome * history of suicidal behavior
uncertainty in hfref patients

Conditions: Heart Failure with Reduced Ejection Fraction

Summary: this study was planned as a descriptive and correlational type study to reveal the effect of perceived uncertainty by heart failure (hf) patients with reduced ejection fraction on quality of life and self-care behaviors. in this study, which aimed to reach 122 inpatients with hf, the dependent variables were quality of life and self-care behaviors, the independent variable will be perceived uncertainty. data will be collected by mishel uncertainty in illness scale-community form (muis-c), left ventricular disfunction scale (lvd-36) and european heart failure self-care behavior scale (ehfsebs). data analysis will basically be done with multivariate analysis of variance (manova).

this study aims to reveal the effect of perceived uncertainty on quality of life and self-care behaviors in hf patients with reduced ejection fraction. this descriptive and correlational study will include 122 hf patients hospitalized in the cardiology department of a university hospital in northern turkey. the sample size was calculated according to parameters based on the power of 90%, 95% confidence interval, error level of 0.05, effect size of 0.59. data will be collected by mishel uncertainty in illness scale-community form (muis-c), left ventricular disfunction scale (lvd-36) and european heart failure self-care behavior scale (ehfsebs). data analysis will basically be done with multivariate analysis of variance (manova).

Eligibility criteria:
inclusion criteria: * 18 years or older, * having been diagnosed with heart failure by a physician for more than 6 months, * left ventricular ejection fraction \<40% as measured by echocardiography, * volunteering in participating in the study exclusion criteria: * being under antidepressant treatment, * presence of a pre-existing psychiatric illness or cognitive impairment, * diagnosed with cancer and being under treatment related to cancer, * presence of chronic obstructive pulmonary disease.

Keywords: self care quality of life uncertainty
approach to hiatal hernia repair based on collagen study

Conditions: Hiatal Hernia; Gastroesophageal Reflux Disease

Summary: groups of patients who underwent laparoscopic repair of large hiatal hernias by primary posterior crural repair and crural repair with progrip™ mesh techniques were examined for recurrence rate of hiatal hernias, quality of life according to the gerd-hrql questionnaire. clinical evaluation was performed at 3, 6, 12, 24, 36, and 48 months after surgery.

the laparoscopic repair of large hiatal hernias is mostly performed by cruroraphy or cruroraphy with mesh reinforcement techniques. cruroraphy it is suturing of the right and left diaphragmatic crura using nonabsorbable stitches. main disadvantage of such technique is the high hiatal hernia recurrence rate after surgery. cruroraphy with mesh reinforcement technique followed by relatively less hiatal hernia recurrence rate but associated with a large number of mesh-related complications.

Eligibility criteria:
inclusion criteria: * age older than 20 years * initially suffering from large hiatal hernia (\>20% of the stomach in the thoracic cavity) * performance of laparoscopic hiatal hernia repair * informed consent as documented by signature exclusion criteria: * cases of conversion to open surgery * age \ 80 years * history of oesophageal/gastric/duodenal surgery including vagotomy
can dynamic ultrasonography replace urodynamics in follow-up of patients with myelomeningocele

Conditions: Neurogenic Bladder; Myelomeningocele

Summary: patients with neurogenic bladder need periodic evaluation with urodynamic study, a invasive and uncomfortable procedure. aim: to evaluate the accuracy of dynamic ultrasonography as a feasible and noninvasive alternative diagnostic method to identify detrusor overactivity in patients with neurogenic bladder

the urodynamic study and dynamic ultrasonography were performed concurrently, to identify detrusor overactivity, in patients with myelomeningocele and clinical indication for urodynamics, by investigators without verbal or visual contact. the overactivity was diagnosed through active conformational change of the bladder during filling phase.

Eligibility criteria:
inclusion criteria: * all outpatients of the pediatric urology department of the investigator's institution with diagnosis of myelomeningocele and clinical indication for urodynamic study exclusion criteria: * previous bladder augmentation surgery * current urinary tract infection * fail to provide consent for participation

Keywords: dynamic ultrasonography spinal dysraphism
establishment of an early warning screening system for hemophagocytic lymphohistiocytosis a multi-center, prospective study

Conditions: Hemophagocytic Syndrome

Summary: our three-step screening system uses commonly used clinical and laboratory parameters to effectively identify patients who may be at high risk of hlh, conduct etiology screening early for patients who meet the diagnostic criteria for hlh, and guide standardized treatment. therefore, this study proposes to establish a highly accurate and convenient hemophagocytic early warning system to improve the early diagnosis of patients with hemophagocytic syndrome and identify suspected hlh patients early. etiology screening is performed on patients who meet the diagnostic criteria for hlh, high-risk predisposing factors are identified, and precise treatment is guided, thereby improving the success rate of patient treatment and improving the quality of life.


Eligibility criteria:
inclusion criteria: subjects must meet all of the following criteria: 1. patients who meet the first step screening + have ≥ 3 abnormal screening indicators in the second step 2. patients who meet the first step screening + have 2 abnormal screening indicators in the second step + patients with high-risk factors for hlh, such as history of lymphoma, ebv infection, autoimmune diseases, etc exclusion criteria: exclusion criteria subjects who meet one of the following criteria will not be enrolled: 1. patients with liver cirrhosis, liver cancer, and hepatic encephalopathy 2. patients with trauma, hepatosplenic rupture and other organ hemorrhage 3. patients with severe disease such as shock, sepsis, and multiple organ failure 4. patients with dic 5. patients with long-term anemia 6. patients with acute promyelocytic leukemia 7. patients with idiopathic deafness 8. patients who have taken hormones/immunosuppressants 72 hours before admission 9. hereditary fibrinogen deficiency

Keywords: hemophagocytic syndrome screening system
buprenorphine combination tablet feasibility - 1

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to determine target dose range of buprenorphine/naloxone combination tablet that provides therapeutic response in opiate addicts with low to moderate dependence, and to identify appropriate initial induction dose in opiate addicts with low to moderate dependence."


Eligibility criteria:
inclusion criteria: males/females ages 21-50, opiate dependence according to dsm-iv criteria, self-reported use within the last 30 days, agreeable to conditions of study and signed informed consent exclusion criteria: psychiatric disorder that requires medication therapy, history of seizures, pregnant and/or nursing women, dependence on etoh or benzodiazepines or other sedative-hypnotics, acute hepatitis, other medical conditions that deem participation to be unsafe.
a comparative study of cosmetic product in subjects with facial acne during an associated-treatment phase followed by a maintenance phase

Conditions: Acne

Summary: in this study, we are interested in the global benefit of the tested product as complementary care to a topical medical treatment during a 3 month-associated treatment phase followed by a 3 month-maintenance phase, compared to a light moisturizing cream, in teenagers and adults with acne. we also want to evaluate the tolerance of the tested product in association and in maintenance of the topical medical treatment.


Eligibility criteria:
inclusion criteria: * male or female aged between 14 and 24 years (included) * subject with facial acne with score index severity iga = 2 or 3, assessed on a scale ranged from 0 to 4. * subject for whom a prescription of 12 weeks of a reference topical medical treatment is required from the day of the inclusion visit, for mild to moderate face acne exclusion criteria: criteria related to the disease: * facial skin disease other than acne, skin abnormalities, or dermatological condition on the face liable to interfere with the study assessments * acne conglobata, acne fulminans, nodulocystic acne or acneiform eruptions, according to investigator's assessment * other type of pigmentation disorder than acne-related pih liable to interfere with the study assessments according to the investigator criteria related to treatments and/or products: - topical or oral treatment established or modified during the previous weeks or planned to be established or modified during the study, liable to interfere with the evaluation of the efficacy or cutaneous tolerance of the investigational products

Keywords: acne face young adults teenagers treatment phase maintenance
promoting asylum-seeking and refugee children's coping with trauma

Conditions: Mental Health Disorder; Post-Traumatic Stress Disorder in Adolescence; Depression; Social Anxiety

Summary: a short term trauma-focused cognitive- behavioral program to reduce trauma-related mental health problems among asylum-seeking and refugee children. the main hypothesis of the study is that the trt program significantly improves mental health (i.e. reduces symptoms of post-traumatic symptoms, depression and generalized anxiety and increases perceived quality of life (qol) in the intervention group compared to the waiting-list control group.

teaching recovery techniques (trt) was developed by children and war foundation (www.childrenandwarfoundation.org ) as a tool to support children in coping with their mental reactions to being exposed to war and catastrophes. trt has proven to be effective in reducing trauma-related mental health symptoms in such contexts. however, it has never been used with children experiencing all the uncertainties and stress of an asylum-seeking context, or with refugee children in high-income countries. the main aim of the present study is therefore to implement and evaluate the trt among asylum-seeking and refugee children in the context of four different care conditions: 1)asylum-seeking children who arrived accompanied by a legal care-taker 2) asylum-seeking children less than 15 years in care centers administered by the child welfare services 3) asylum-seeking children 15 years and older living in asylum centers regulated by the directorate of immigration 4) former unaccompanied asylum-seeking children who have been granted residence (refugees) and are resettled in a municipality in norway. based on power analyses, the target group is 40 children in each care condition (total n = 160) \> 9 years speaking arabic, tigrinya, somali, dari, or pashto. the study employs a randomized clustered experimental design that includes a waiting list control group, which will receive the trt when the intervention group has completed the program.

Eligibility criteria:
inclusion criteria: * accompanied asylum-seeking children living in reception centers, * unaccompanied asylum-seeking children living in reception centers * unaccompanied refugee minors who have been granted residence children in the target groups reported symptoms of post-traumatic stress above clinical cut-off on children's revised impact of event scale, 8 items - exclusion criteria: * psychosis, * mental disabilities

Keywords: teaching recovery techniques asylum-seeking children refugee children low-threshold intervention
procedural sedation using propofol versus midazolam/ketamine in the adult emergency department

Conditions: Procedural Sedation

Summary: the use of procedural sedation and analgesia (psa) to accomplish painful procedures in the emergency department (ed) has become a standard of practice over the last decade. substantial variance exists regarding usage of medication for psa, and many anesthetic agents have been proposed for this use. to our knowledge no head to head study compared the clinical effectiveness, safety profile and amnestic properties of midazolam/ketamine vs. propofol regimens for psa in the adult ed setting. this prospective randomized trail can will help to evaluate the effectiveness and safety profile of midazolam/katamine regimen for ed psa in adults and will contribute to the discussion regarding propofol roll in the ed.


Eligibility criteria:
inclusion criteria: * patients with orthopedic injuries requiring painful manipulation (i.e. reduction of fracture or dislocation, drainage of abscess, suture of extensive laceration) * age between18-65 years * american society of anesthesiologists (asa) score of 1 or 2 * systolic blood pressure higher than 90 mmhg and lower than 160 mmhg before initiating sedation * willingness and ability to provide an informed consent * no known hypersensitivity to either medication * no evidence of intoxication * no recent heavy meal. exclusion criteria: * pregnant women and patients who do not meet the above criteria will be excluded.

Keywords: procedural sedation and analgesia emergency department propofol versus ketamine and midazolam painful orthopedic manipulations
role of ultrasonography in the diagnosis of carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: this prospective study aims to evaluate the median nerve in carpal tunnel syndrome by high-frequency ultrasound and color doppler in comparison with clinical and nerve conduction studies.

this prospective study aims to evaluate the median nerve anatomical changes in carpal tunnel syndrome by high-frequency ultrasound and color doppler in comparison with clinical and nerve conduction studies physiological changes to determine the efficacy of ultrasound to diagnose and determine the severity of carpal tunnel syndrome.

Eligibility criteria:
inclusion criteria: * any age group with symptoms, clinical signs and ncs consistent with cts exclusion criteria: * uncooperative patients . * patients with history of previous wrist surgery, fracture or traumatic nerve injury
using mhealth to improve emotional recovery after pediatric injury

Conditions: Trauma Injury; Child, Only; Posttraumatic Stress Disorder; Parents

Summary: nearly 300,000 u.s. children experience injuries that require them to be hospitalized this year. these children, and their caregivers, are at high risk for emotional and behavioral problems, as well as poor quality of life. trauma centers in the us have good outcomes for survival and physical recovery, but they typically do not have programs to address the emotional and behavioral needs of families. the purpose of this project is to develop a service that achieves this and that can serve as a good model for trauma centers to use. this project will develop, evaluate, and test caare (caregivers' aid to accelerate recovery after pediatric emergencies) to address the behavioral and emotional needs of caregivers and children.

this project consists of three main study aims. the first aim is to finalize the caare model and research protocol in preparation for the open trial (aim 2). to complete this study aim, caare will first be refined guided by preliminary work led by the pi with caregivers after pediatric traumatic injury (pti). then, we will conduct usability testing and refine the mhealth components of caare with about 10 caregivers in preparation for the open trial (aim 2). finally, we will debug the research protocol via implementation of the full caare intervention with approximately 5 families prior to conducting the open trial. aim 2, the open trial, is described in more detail in the arms/intervention section. aim 3 is to assess caare implementation feasibility with families, trauma center leaders, and program managers. this will be conducted through qualitative interviews with (1) \~20 caregivers who participated in the open trial - diverse with respect to race, child age, and mental health status - to assess their reactions to caare; (2) \~15 pediatric trauma center directors and \~15 pediatric trauma program managers to identify perceived barriers and facilitators associated with implementing caare in pediatric trauma centers.

Eligibility criteria:
inclusion criteria: * caregivers of children who experience pediatric traumatic injury * children younger than 12 * caregivers older than age 18. exclusion criteria: * caregiver's primary language is not english * self-afflicted injury * injuries resulting from caregiver abuse or neglect
multiple rising dose study of bi 144807 powder in bottle in mild asthmatic patients

Conditions: Healthy; Asthma

Summary: in this trial the safety, tolerability, pharmacokinetics and exploratory pharmacodynamics of multiple dose administration of bi 144807 will be investigated in otherwise healthy, controlled asthmatic patients


Eligibility criteria:
inclusion criteria: 1. mild asthmatic, otherwise healthy subjects (male and female of non-childbearing potential) exclusion criteria: 1. apart from mild asthma any relevant deviation from healthy conditions