Kornimate/medical-research-clean huggingface dataset:
ctdna in crc patients undergoing curative-intent surgery for liver metastases

Conditions: Metastatic Colorectal Cancer; Circulating Tumor DNA

Summary: this is a prospective multicenter cohort study, was designed to explore the prognostic value of ctdna as a biomarker of disease response and recurrence or death in patients undergoing curative-intent surgical resection of colorectal cancer liver metastasis.

blood collection times according to specific clinical situations: * standard approach * combined surgery * reverse strategy * two-stage hepatectomy

Eligibility criteria:
inclusion criteria the patient will be included if: 1. has signed informed consent form and is willing to comply with all study procedures and availability for the study duration, 2. is ≥ 18 years of age, 3. has histologically confirmed colorectal adenocarcinoma, 4. has resected primary tumor or is eligible to primary tumor and crlm (in case of synchronous metastases) resection within 6 months prior to study inclusion, 5. has isolated crlm that is deemed resectable or potentially resectable (extrahepatic metastases excluded, except infracentimetric non-specific lung lesions with largest diameter \<1 cm and maximal number of ≤3) as judged by a multidisciplinary team meeting (based on ct scans of chest, abdomen, and pelvis \[or mri if ct not possible\]), 6. is eligible to surgical procedure, 7. is fit for the chemotherapy-surgery combination treatment, 8. is registered in a national health care system (protection universelle maladie \[puma\] included). exclusion criteria the patient will be excluded if: 1. has definitively unresectable clrm, 2. had more than 9 pre-operative cycles of chemotherapy for treatment of metastatic disease planned at inclusion, 3. has not resected primary rectal tumor (low and middle), 4. has history of another primary cancer within the last 5 years, with the exception of non-melanomatous skin cancer and carcinoma in situ of the cervix, 5. has no more than two surgical procedures planned for complete resection of primary tumor and/or liver metastases, 6. has deficient mismatch repair (dmmr)/ microsatellite instability (msi) tumors treated with immunotherapy, 7. blood samples cannot be collected if surgical procedure, 8. is pregnant or breastfeeding, 9. cannot be followed-up due to geographical, social, or psychic conditions, 10. has medical or psychiatric condition or occupational responsibilities that may preclude compliance with the protocol, 11. is under guardianship, curatorship, or under the protection of justice.
isopropyl alcohol against chlorhexidine - isopropyl alcohol as antiseptics to prevent hemoculture's contamination

Conditions: Infectious Diseases

Summary: the purpose of this study is to determinate if 70% isopropyl alcohol is not inferior preventing contamination of peripheral hemocultures, compared with 2% chlorhexidine in 70% isopropyl alcohol.

the develop of contaminants in blood cultures is a problem of great impact to health institutions and patients, as they represent a waste of resources, and additionally increases the patient's hospital stay. the principal source of contaminant is the bacteria in the skin flora, so the greatest way to improve the sensibility of this test is to do an optimal skin antisepsis. it has been reported that 2% chlorhexidine gluconate in 70% isopropyl alcohol is superior that other skin disinfectants, and that 70% isopropyl alcohol has a high efficacy reducing the presence of bacteria on the skin, so both antiseptics are good options for skin antisepsis.

Eligibility criteria:
inclusion criteria: * patients with suspected blood stream infection. * patients allocated in admission, hospitalization and intensive care units. exclusion criteria: * patients with a single peripheral hemoculture.

Keywords: antiseptics hemoculture contamination anti-infecting agents, local
the effect of different food products on post prandial blood glucose in pregnant woman with diabetes

Conditions: Type 1 Diabetes; Type 2 Diabetes; Gestational Diabetes

Summary: during pregnancy nutrition demands change and the pregnant woman needs to adjust her food intake and take into consideration the corrected daily recommendations for micro and macro nutrients. pregnant woman tend to suffer from hyperemesis and this affects their food choice. amongst pregnant women with diabetes the glucose balance is extremely important during pregnancy. glucose balance is a result of correct nutrition and an exact amount of insulin. this delicate balance requires from the pregnant women an ability to perform correct carbohydrate count. hyperglycemia has already been proven to affect the fetus and the neonatal outcomes. hypoglycemia may also have a negative effect but the main danger is immediate harm to the mother and therefore to the fetus. for those reasons glucose balance is crucial and demands delicate synchronization of nutrition and insulin therapy.


Eligibility criteria:
inclusion criteria: * age 18-45 * women who suffer from type 1 diabetes, type 2 diabetes or gestational diabetes * do not suffer from any intestinal disease * accept to sign a consent form exclusion criteria: * over age of 45 * under age of 18 * suffer from any intestinal disease * do not accept to sign a consent form
testing thrive 365 for black sexual minority men (on the daily)

Conditions: Medication Adherence; Depressive Symptoms; Anxiety Symptoms; Emotion Regulation

Summary: the primary goal of this study is to test a minority stress model of psychological health outcomes for black sexual minority men (bsmm) while using and not using a novel intervention named thrive 365. thrive 365 combines mhealth and institutional support elements to provide four areas of support for bsmm: 1) promote hiv and psychological health knowledge and motivation; 2) foster a sense of community and positive social connections among bsmm; 3) connect clients to bsmm-affirming healthcare, including hiv treatment and mental healthcare; 4) provide resources for housing, transportation, and other economic empowerment. to examine the effects of the intervention, we will utilize a 14-day daily diary study to capture daily intervention engagement, hiv and psychological health outcomes, coping, and experiences of racial and sexual minority stressors. we will first examine main associations between intervention engagement and hiv (antiretroviral treatment use) and psychological health (depressive symptoms, anxiety symptoms, emotion regulation difficulties outcomes) outcomes, then consider how intervention engagement affects coping and attenuates the impacts of racial and sexual minority stressors during the 14 day period.


Eligibility criteria:
inclusion criteria: * 16 years old or older ; * identifying as masculine * identifying as black/african american * reporting being attracted to and/or sexually active with men; * able to complete all procedures in english. * mobile access to the internet in order to complete the once-daily survey procedures. exclusion criteria: * evidence of unstable, unmanaged, or serious psychiatric symptoms that could be made worse by participation; * evidence of gross cognitive impairment that would interfere with successful completion of study procedures.
evaluation of treatment with fixture microthread™ in patients missing all teeth in the upper jaw, when using one-stage surgery

Conditions: Jaw, Edentulous

Summary: the primary objective of the study is to evaluate the long-term survival rate of implants and prostheses when treating totally edentulous upper jaws with fixture microthread (micro-macro) using a one-stage surgical procedure. clinical study recruitment was stopped in year 2000 due to a decision to modify the product under study. this was a result of feedback regarding the subjective feeling during the installation procedure. there were no safety concerns w/r to the study products. patients already included and treated in the study were monitored for the full duration of the study in accordance with the clinical study protocol.


Eligibility criteria:
inclusion criteria: * 18-75 years of age * sufficient amount of bone to give good support for implants of at least 9 mm length. * willing to give signed informed consent exclusion criteria: * any systemic disease or condition that would compromise post-operative healing and/or osseointegration * systemic corticosteroids or any other medication that would compromise post-operative healing and/or osseointegration * unable or unwilling to return for follow-up visits
efficacy of subcutaneous infliximab in acute severe ulcerative colitis: a multicenter retrospective study

Conditions: Ulcerative Colitis

Summary: around 25% of patients with ulcerative colitis will develop acute severe colitis during the course of their disease. the first-line treatment for acute severe colitis is intravenous corticosteroid therapy. in case of a cortico-resistant form, treatment with intravenous (ciclosporin or infliximab is indicated), according to european guidelines. the emergence of biosimilar in the last years is a turning point in a context of optimizing healthcare costs and improving patient quality of life, with the arrival of the subcutaneous form of infliximab in 2020, with similar results in terms of clinical remission, but also blood levels of infliximab compared with the intravenous form. to our knowledge, there are very few data on the use of subcutaneous infliximab after intravenous induction in patients with acute severe colitis. the aim of this study is to evaluate the efficacy of subcutaneous infliximab in ulcerative colitis patients with acute severe colitis, and the factors associated with treatment failure.


Eligibility criteria:
inclusion criteria: * patient ≥ 18 years old * diagnosis of acute severe ulcerative colitis according to truelove witts criteria * patients treated with at least one injection of subcutaneous infliximab after induction with two or three intravenous perfusions of infliximab * patients with a follow-up of at least 12 months after the first subcutaneous injection * 12-month data available in medical records * patient who has received full information about the organization of the research and who has not objected to his or her participation and to the use of his or her data. exclusion criteria: * patients with intravenous infliximab as a maintenance treatment * patients switched from intravenous to subcutaneous form during follow-up, and who received more than three intravenous perfusions * protected persons.
development of an imaging prediction model for pelvic lymph node metastasis of cervical cancer using artificial intelligence techniques.

Conditions: Cervical Cancer; Lymph Node Metastasis; Artificial Intelligence

Summary: this study is a retrospective exploratory trial conducted at a single center, aiming to develop and validate a preoperative lymphatic metastasis model for cervical cancer using artificial intelligence deep learning. the model is trained using preoperative imaging and postoperative pathological findings of cervical cancer patients, with the goal of enhancing the accuracy of lymphatic metastasis prediction through preoperative imaging and offering insights for treatment decisions.


Eligibility criteria:
inclusion criteria: 1. patients with preoperative diagnosis of invasive cervical cancer stage i-iii, with any type of pathology, and patients who underwent radical/modified radical cervical cancer surgery + pelvic lymph node dissection in our hospital. 2. age ≥18 years old and ≤80 years old 3. patients with complete preoperative pelvic mri images and postoperative pathology and clinical data in our hospital exclusion criteria: 1. patients during pregnancy or breastfeeding, patients within 42 days of abortion 2. patients who have received neoadjuvant chemotherapy or radiotherapy before surgery for this previous cervical cancer 3. patients with other malignant tumors within 5 years 4. combination of other underlying diseases that may lead to enlarged pelvic lymph nodes 5. imaging report more than 1 month prior to surgery 6. poor image quality and unrecognizable

Keywords: cervical cancer lymph node metastasis artificial interlligence
development and validation of a bowel-routine-based self report questionnaire for sacral sparing after spinal cord injury

Conditions: Spinal Cord Injuries

Summary: to develop a self-administered tool for assessment of sacral sparing after spinal cord injury (sci) and to test its validity in individuals with sci.


Eligibility criteria:
inclusion criteria: * patients with sci exclusion criteria: * had neurologic impairments unrelated to sci, such as peripheral nerve injury, brain injury and cognitive deficits, or if they were unable to complete the questionnaire.
statin therapy in the treatment of sepsis

Conditions: Septic Shock

Summary: simvastatin will attenutat il-6 levels and lead to a more rapid shock reversal than placebo


Eligibility criteria:
inclusion criteria: * greater than 18 years old * hypotensive requiring vasopressors * suspected infection exclusion criteria: * pregnant * liver failure (alt or ast \> 120) * rhabomyolysis (cpk \> 3x normal) * comfort care measures status * chronic liver disease (cirrhosis) * use of cyclosporin, digoxin, statins * patients who are unable to take medications by mouth or ngt

Keywords: statin, sepsis, septic shock, simvastatin
pharmacokinetic study of milrinone in babies with persistent pulmonary hypertension of the newborn

Conditions: Persistent Fetal Circulation Syndrome

Summary: the purpose of this pilot study is to determine a safe dose of milrinone to use in a larger study of babies with persistent pulmonary hypertension of the newborn (pphn).

persistent pulmonary hypertension of the newborn (pphn) is a condition in which the pulmonary vasculature fails to relax after birth resulting in severe hypoxemia. this condition has a high rate of mortality and morbidity. the current standard of care is treatment with inhaled nitric oxide (ino). however, for many babies this treatment does not provide sufficient improvement in oxygenation. in this study, subjects already receiving nitric oxide will be randomized to one of two dosing regimens of milrinone. they will receive milrinone iv for 24 hours and will be monitored for 24 hours afterwards. during this time, milrinone assays will be performed by blood sampling. echocardiograms will also be performed to explore the pharmacodynamics of milrinone. safety monitoring will be performed.

Eligibility criteria:
inclusion criteria: * gestational age \> 34 weeks * post-natal age \< 10 days * hypoxemia defined by: oxygenation index (oi) \>15 (mean airway pressure x fraction of inspired oxygen (fio2) x 100 /pao2) as drawn from two post-ductal arterial blood gas samples (in-dwelling arterial catheter) taken at least 15 minutes apart. or mechanically ventilated and with \>75% fio2 for \>6 hours while on ino * absence of congenital heart disease based on a two-dimensional echocardiogram and/or clinical assessment * an in-dwelling arterial catheter to facilitate painless sampling * currently on ino or plan to start ino before enrollment exclusion criteria: * lethal non-cardiac congenital anomalies including diaphragmatic hernia * clinically apparent bleeding; thrombocytopenia \<30,000 or other laboratory evidence of coagulopathy * currently on extracorporeal membrane oxygenation (ecmo)or plan to initiate ecmo within 2 hours of enrollment

Keywords: persistent pulmonary hypertension of newborn pphn persistent pulmonary hypertension pulmonary hypertension pulmonary hypertension of newborn
parity and serum lipids in white and hispanic women

Conditions: Atherosclerosis; Cardiovascular Diseases; Heart Diseases

Summary: to analyze the relationships between parity (childbirth) or gravidity (pregnancy) and measures of lipids in groups of women from the hispanic health and nutrition examination survey (hispanic hanes) and the framingham heart study.

background: the relationships between parity or gravidity and measures of lipids in groups of women from the hispanic health and nutrition examination survey (hispanic hanes) and the framingham heart study offered insights into the health of an important minority group in the united states and provided clues regarding hormonal mechanisms in lipoprotein metabolism. design narrative: in the framingham cohort, the relationships among gravidity, ldl-cholesterol, hdl-cholesterol and total cholesterol were prospectively studied. each of these serum lipids was tested as a potential mediator of associations between gravidity and various cardiovascular endpoints. in the hispanic hanes, the associations among parity, gravidity, and lipid levels were examined in cross-sectional data on women of a different ethnic background in whom birth rates tended to be high. secondary analysis of these two datasets was conducted, carefully considering aspects of the study designs. bivariate analyses generated mean lipid levels within parity or gravidity groups. hdl, ldl, and total cholesterol were then stratified both by parity and other variables (such as age and smoking status) so that interactions could be considered. multivariate analyses were used to analyze the effect of parity on lipids and cardiovascular disease events while controlling for a variety of potentially confounding factors (such as body mass index, subscapular/triceps, skinfold ratio, education, income, cigarette smoking, alcohol consumption, oral contraceptive use, estrogen replacement therapy, menopausal status and type of menopause). interactions were also considered in multivariate models.

Eligibility criteria:
no eligibility criteria
immune function in elderly patients with mild to moderate covid-19 on hemodialysis

Conditions: COVID-19; Hemodiafiltration

Summary: this randomized controlled trial will focus on the effects of early oral nutritional supplementation on immune function in elderly patients with mild to moderate covid-19 on maintenance hemodialysis. the purpose of this study is to determine whether early oral nutritional supplementation can improve immune function and clinical outcomes.

covid-19 is in the midst of a global pandemic. elderly patients are often susceptible and at high risk. elderly patients on maintenance hemodialysis are often accompanied by a variety of complications, malnutrition is a common complication with an incidence of 23-73%. due to a variety of risk factors, covid-19 infection tends to develop into severe disease, and it takes longer for nucleic acid to turn negative. this randomized controlled trial will focus on the effects of early oral nutritional supplementation on immune function in elderly patients with mild to moderate covid-19 on maintenance hemodialysis. the purpose of this study is to determine whether early oral nutritional supplementation can improve immune function and clinical outcomes.

Eligibility criteria:
inclusion criteria: 1. aged 60 and above; 2. patients receiving hemodialysis with clinically confirmed end-stage renal disease 3. positive diagnosis of covid-19 by rt-pcr nasopharyngeal swab was classified as mild or moderate type 4. patients who can eat on their own; 5. patients had good compliance, fully understood the study content and signed informed consent. exclusion criteria: 1. contraindications of oral nutritional supplementation, such as intestinal obstruction and intestinal ischemia. 2. in an unstable state of vital signs such as shock. 3. in acute pancreatitis, cholecystitis acute attack period and 3 months after the last attack 4. patients with moderate to severe cognitive impairment or mental diseases; 5. people who are allergic to intestinal nutrients 6. refuse oral nutritional supplements

Keywords: covid-19 hemodiafiltration immune function oral nutritional supplement
neuroinflammatory pet imaging in autoimmune encephalomyelitis

Conditions: Autoimmune Encephalomyelitis

Summary: autoimmune encephalomyelitis is a heterogeneous group of central nervous system (cns) autoimmune diseases characterized by the production of anti-neuron-associated autoantibodies which target neuronal surface proteins, synaptic receptors and intracellular antigens. mri, as a current first-line imaging tool of cns inflammation, is difficult to diagnose them because the majority of patients have normal mri images, and only a few may show local signal or structural abnormalities (including inflammation, edema, or atrophy). the 18 kda translocator protein (tspo) expression in the cns is upregulated in response to microglia activation. dpa-714 is high affinity for binding to tspo, making 18f-labeled dpa-714 (18f-dpa-714) pet a very promising diagnostic imaging tool for neuroinflammation in patients with autoimmune encephalomyelitis.this study aims to explore the value of 18f-dpa-714 pet in the early diagnosis, therapeutic assessment and prognosis in patients with autoimmune encephalomyelitis.


Eligibility criteria:
experimental group: inclusion criteria: 1. patients with onset for less than 2 years 2. serum autoantibody positive 3. cognitive impairment or movement disorder diagnosed by two or more certified specialists. exclusion criteria: 1. patients who do not meet the clinical、laboratory and imaging criteria of immune-related cognitive and movement disorders 2. medical history of surgery, trauma, stroke, tumor in brain or spine cord 3. alcoholism or drug dependence (addiction) 4. patients with pregnancy healthy volunteers group: inclusion criteria: 1. able to understand the purpose of clinical research and test plan 2. in the brain and spine cord mr assessment, it is judged as "normal" exclusion criteria: 1. any major mental illness; history of schizophrenia or schizoaffective disorder 2. any important neurological disease, such as cerebrovascular disease, inflammation or infectious disease, demyelinating disease, neurodegenerative disease, trauma in brain or spine cord 3. history of alcohol or drug abuse/dependence 4. medical history of cardiac and lung disease, tumors, blood disease, poorly controlled chronic diseases 5. patients with pregnancy