Kornimate/medical-research-clean huggingface dataset:
rhythmic auditory stimulation and walking speed in the 6-minute walk test

Conditions: Myasthenia Gravis

Summary: the aim of this study is to investigate if rhythmic auditory stimulation can influence walking speed, during a 6mwt in patients with myasthenia gravis (mg).

background 1. the 6-minute walk test (6mwt) is widely used in the clinic to measure treatment efficacy and disease progression in patients with neuromuscular diseases and is found valid and reliable to measure decrease in walking speed. 2. rhythmic auditory stimulation has repeatedly been shown to improve gait parameters in individuals with neurologic impairment. the aim of this study is to investigate if rhythmic auditory stimulation can influence walking speed, during a 6mwt in patients with myasthenia gravis. patients with mg are asked to complete two 6mwts separated by minimum 30 minutes of rest. before the 6mwts patient is instructed to walk 60 m as fast as possible, and their steps per minute (spm) is recorded. when completing the 6mwts, one of the tests is accompanied by music (m6mwt) with a beat per minute (bpm) corresponding to patients' spm. the order of the 6mwts is randomly decided by pre-ordered sealed envelopes.

Eligibility criteria:
inclusion criteria: * able to provide signed informed consent. * able to read and understand danish or english. * diagnosis of mild to moderate mg (able to provide signed informed consent. * able to read and understand danish or english. * diagnosed with generalized mild to moderate myasthenia gravis (i-iv on the myasthenia gravis foundation of american clinical classification, mgfa). * documented history of acetylcholine receptor (achr) or muscle specific kinase (musk) antibody positive, or abnormal repetitive nerve stimulation testing (decrement \> 10%) on electromyography (emg) or abnormal single fiber emg (conduction block or jitter) or based on their clinical history and symptom improvement with acetylcholinesterase inhibitors. * ability to walk \> 60 meters in a 6mwt. exclusion criteria: mgfa grade v disease * other disorders that are not related to mg, or drugs, that interfere with muscle strength, walking ability, balance and fatigue (e.g. heart failure). * serious medical illness (e.g. uncontrolled insulin dependent diabetes mellitus, symptomatic coronary artery disease, and cancer). * dementia or pregnancy. * unspecified reasons judged by the investigator

Keywords: fatigue 6-minute walk test rhythmic auditory stimulation
observational study to assess transradial access for treatment in the lower extremities.

Conditions: Peripheral Arterial Disease

Summary: this study is designed to collect data on the complication rates and procedural success of using a transradial access approach to treat peripheral lesions in the lower extremities of a real world population.


Eligibility criteria:
inclusion criteria: * rutherford category 2-5 * subject scheduled for a transradial intervention to treat a lesion in the lower extremities. * willing to sign consent and agree to follow-up requirements. exclusion criteria: * previous failed transradial access attempt * presence of or planned dialysis fistula. * planned amputation * previous or planned transradial access intervention +/- 30 days * radial artery diameter \<2.5mm * no palpable radial artery * established vasospastic disease * known allergy to contrast that cannot be managed * pregnant or lactating * mentally incompetent or a prisoner * currently participating in a clinical study that has not completed it's primary endpoint
safety and effectiveness of an anti-hiv drug combination in hiv-positive patients who have failed previous treatment with protease inhibitors

Conditions: HIV Infections

Summary: the purpose of this study is to see if it is safe and effective to give an anti-hiv drug combination containing indinavir and ritonavir to hiv-positive patients who have failed previous treatment with protease inhibitors.

patients receive indinavir and ritonavir twice daily plus 2 nrtis (nrtis are not provided by this study). physical examinations and laboratory tests, including plasma viral rna levels and cd4 cell counts, are performed at day 1 and weeks 4, 8, 12, 16, 20, and 24 (or at discontinuation). the incidence of serious and drug-related adverse experiences is tabulated to determine drug safety. the proportion of patients achieving plasma viral rna levels below 50 copies/ml (by ultrasensitive assay) are estimated statistically to determine drug efficacy.

Eligibility criteria:
inclusion criteria you may be eligible for this study if you: * are hiv-positive. * have a viral load (level of hiv in the blood) of 2500 copies/ml or greater within 45 days of study entry. * have a cd4 cell count of 100 cells/mm3 or greater within 45 days of study entry. * have been on an anti-hiv drug regimen containing a protease inhibitor for at least 16 weeks and initially did well on this treatment (your viral load decreased significantly) but later experienced treatment failure on this drug combination (your viral load increased significantly). * experienced treatment failure within 24 weeks of study entry. * are 18 years of age or older. * agree to use effective barrier methods of birth control (such as condoms) during the study. exclusion criteria you will not be eligible for this study if you: * are allergic to ritonavir or indinavir. * have hepatitis. * have an abnormal chest x-ray or abnormal liver function tests. * have taken 2 protease inhibitors at the same time for 7 or more days. * have taken non-nucleoside reverse transcriptase inhibitors (nnrtis) in the 2 weeks before study entry. * have a medical condition that might make it unsafe for you to take the study drugs. * have experienced resistance to nrtis and no new nrti therapy is possible. * have taken certain medications. * abuse alcohol or drugs. * are pregnant or breast-feeding.

Keywords: drug therapy, combination hiv protease inhibitors ritonavir indinavir reverse transcriptase inhibitors anti-hiv agents viral load
post exercise substrate oxidation, appetite and energy intakes in overweight/obese postmenopausal women (escape)

Conditions: Overweight; Postmenopausal

Summary: high-intensity interval exercise (hiit), as compared to moderate intensity continuous training (mict), is a time-efficient strategy to decrease total and abdominal fat mass (fm). however, the mechanisms underlying such adaptations are not yet elucidated and research are still needed to establish the optimal hiit according to subject characteristics. the aim of this study was to compare acute hiie and mice cycling exercises on enjoyment, post-exercise substrate oxidation, appetite and energy intakes over 24h in postmenopausal women with overweight or obesity. it is hypothesized that compared with the traditional mice, hiie could favor greater enjoyment, higher 2h-post-exercise fat oxidation and a similar energy intakes over 24h despite different post-exercise appetite perceptions.

the aim of this study was to compare acute hiie and mice cycling exercises on enjoyment, post-exercise substrate oxidation, and appetite and energy intakes over 24h in postmenopausal women with overweight or obesity. using a randomized crossover design, 12 postmenopausal women completed 3 cycling exercises at 6-days intervals: i) moderate intensity continuous exercise (mice) which consisted of 35 min cycling at 60-65% theorical peak heart rate (thphr) ii) high intensity interval exercise 1 (hiie 1) 60 cycles of speeding up for 8 s at 80-90%thphr followed by pedaling slowly for 12 s (20min) iii) high intensity interval exercise 2 (hiie 2) which consisted of repeated 10 x 1min at 80-90% thphr followed by pedaling slowly for 1min. substrate oxidation (cho and fat) were measured at rest and 2h- post exercise. enjoyment, perceived exertion and appetite were recorded and post-exercise energy intakes were assessed over 24h.

Eligibility criteria:
inclusion criteria: * postmenopausal women (spontaneous amenorrhea for at least 12 months) * with overweight or obesity (bmi \> 25 kg/m2 and ≤ 40 kg/m2) exclusion criteria: * medical contraindications to intense physical activity, * painful joints, * taking hormone replacement therapy, * taking b-blockers.

Keywords: exercise modalities postmenopausal women high-intensity interval exercise cho and fat oxidation appetite energy intakes enjoyment
chinese obesity and metabolic surgery database (comes database)

Conditions: Obesity; Metabolic Surgery; Bariatric Surgery; Weight Loss

Summary: the purpose of the chinese obesity and metabolic surgery database (comes database) is to collect data and examine the long-term effects of metabolic and bariatric surgery on obesity and metabolic disorders in the chinese population.

comes database is a prospective managed national database to collect data and examine the long-term effects of metabolic and bariatric surgery on obesity and metabolic disorders in the chinese population.

Eligibility criteria:
inclusion criteria: * patients diagnosed as obesity undergoing metabolic and bariatric surgery. exclusion criteria: * patients treated by non-surgical modalities.

Keywords: obesity metabolic surgery bariatric surgery weight loss
early waning of maternal measles and meningitis c antibodies

Conditions: Measles

Summary: maternal antibodies (measles and meningitis c) may wane in the first six months after birth. * geometric mean titers(gmts) of measles and meningitis c. * follow-up on 0 month, 3rd month,5th month and 7th month after birth.

measles and meningitis c are hot topics in china in recent years. although china had set the goal of measles elimination, many measles cases were found to be those aged \< 8 months and meningitis c is becoming public health issue since meningitis group a has been controlled at a very low level and little is known on c group. so the investigators designed the observation study on the two antibodies. maternal antibodies are supposed to wane after birth. serums of the placenta(0 month), children of 3 months, 5 months and 7 months old will be collected and the geometric mean titers (gmts) of measles and meningitis c will be confirmed by using the elisa test.

Eligibility criteria:
inclusion criteria: * healthy infants. exclusion criteria: * infants with poor score.

Keywords: measles meningitis c waning geometric mean titer china
circulating " cancer cells / macrophage " hybrid cells in patients with sarcoma, part 2

Conditions: Leiomyosarcoma

Summary: pilot, prospective, monocentric study aimed at evaluating the rate of patients with circulating "cancer cell/macrophage" hybrid cells in the peripheral blood and the evolution of this rate over time. the study will be conducted on a population of patients with leiomyosarcoma and treated in the context of routine care. 20 patients will be included: * 10 patients with localized disease. * 10 patients with metastatic disease. for each included patient, blood samples will be collected during baseline visit and up to 24 months after inclusion.


Eligibility criteria:
inclusion criteria: 1. patient with leiomyosarcoma. 2. diagnosis of sarcoma histologically confirmed by the rreps network (réseau de référence en pathologie des sarcomes et des viscères) 3. localized or metastatic disease 4. newly diagnosed patient who has not yet initiated specific treatment for sarcoma 5. age ≥ 18 years 6. patient affiliated to a social security system in france. 7. patient having signed informed consent prior to inclusion in the study and prior to any specific study procedures exclusion criteria: 1. diagnosis of any other histological subtype of soft tissue sarcoma 2. associated pathology(ies) that may interfere with the study procedure 3. pregnant or breastfeeding woman 4. any psychological, family, geographical or sociological condition that does not allow for compliance with the medical follow-up and/or procedures provided for in the study protocol. 5. patient who has forfeited his/her freedom by administrative or legal award or who is under legal protection (curatorship and guardianship, protection of justice).

Keywords: leiomyosarcoma cancer cell/macrophage hybrid cells hybrid cells
urinary kallikrein and hypertension: a prospective study

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension

Summary: to determine whether low total urinary kallikrein activity was prospectively associated with new hypertension onset or elevated blood pressures.

background: statistical evidence had been found for a dominant major gene segregating in large pedigrees for high urinary kallikrein levels protecting against hypertension which explained 51 percent of the variance of total urinary kallikrein (tuk). in normotensive adult and pediatric pedigree members, low urinary kallikrein activity was associated with a positive family history of hypertension, stroke, and/or coronary disease. design narrative: the presence of a previously reported dominant major gene inferred from segregation analysis of total urinary kallikrein activity (tuk) in selected pedigrees was verified on already collected frozen urine specimens. subjects were rescreened to obtain measured nine year follow-up blood pressure data. individuals were classified by assigned baseline tuk genotype and tested to determine whether low tuk was prospectively associated with new hypertension onset or elevated blood pressures. because a major gene effect was implicated, available probes for the structural kallikrein gene or other related products regulating kallikrein were tested for genetic linkage to tuk levels. correlations with over 600 variables measured at baseline in pedigrees and twins were tested to analyze the strong familiality of environment, refine the genetic analyses to better assign genotypes, and detect gene-environment interactions. all baseline variables except kallikrein, aldosterone, and prostaglandin measurements on frozen urine and follow-up blood pressure had already been collected. tuk may be a marker for a renal, cellular or other physiological abnormality influencing both tuk expression and susceptibility to hypertension. therefore, the relationship of tuk to urinary aldosterone, prostaglandin e excretion and already measured urinary electrolytes, plasma renin activity, and baseline and reactive blood pressures was determined. genetic segregation analyses were performed of the urinary variables and other variables closely associated with tuk.

Eligibility criteria:
no eligibility criteria
identifying risk factors for falls in patients with a high risk of fracture using connected insoles (feetme monitor® device)

Conditions: Fall; Fall Patients; Osteoporosis

Summary: the objective of this study is to determine which gait parameters measured at home using e feetme® insoles are associated with a risk for falls in a patient population suffering from osteoporosis and a higher with high risk of fractures and falls. each patient will be asked to go to 3 visits at the cochin hospital, and to wear the soles after each of these visits during 3 days, at home, to record the data, so that it reflects walking patterns of the patient in his/her daily life and activities. at the eachvisit, clinical tests to assess fall risk will be performed (timed up and go test, one foot stance, short physical performance battery and 6 minutes walking test ). the patients will be supplied with a pair of feetme® monitor insoles, return home and walking parameters will be recorded for 3 to 10 consecutive days.


Eligibility criteria:
inclusion criteria: * male and female subjects aged 60 years and above * with a high fracture and fall risk defined by osteoporosis (low-trauma fracture within the last 5 years and/or osteoporotic bone density) * a fall within the last year, who own a smartphone. exclusion criteria: * cognitive deficit or concomitant disorder limiting communication or participation in the study * simultaneous participation in another study * deprivation of liberty due to a legal or administrative decision * patients receiving psychiatric care * adults beyond the age of majority under legal protection measures or unable to express their consent * patients admitted to a health or social establishment for reasons other than research.

Keywords: feetme insoles fall osteoporosis
nutritional video intervention using mindfulness-based principles

Conditions: Simple Obesity

Summary: the purpose of this study is to access the acceptability and potential utility of nutritional intervention videos in 1) changing knowledge and attitudes about healthy eating, 2) improving healthy food shopping practices, and 3) enhancing skills for stress reduction during food shopping among low-income latina mothers.

* low income latina mothers (n=218) who are primary grocery shoppers for the family will be recruited through community based organization to take part in the study. participation will include completion of survey instruments at baseline, immediately following the intervention; and a subset of participants (n=68) will also complete a 2-month follow-up survey and provide up to two weekly grocery store receipts from the prior 1-2 months at baseline and 2-month followup assessment points. the survey will collect data on demographics, knowledge about healthy eating, self efficacy, perceived stress and family history of relevant health issues. grocery store receipts will be coded and used to evaluate pre-post changes in shopping of healthy vs unhealthy foods. the study compares two conditions: in the control condition, participants will view a 14-minute video on grocery shopping that teaches participants how to make healthy food choices. in the intervention condition, participants will view the aforementioned video in addition to a 15-minute video on how to manage stressors that arise during grocery shopping. -surveys are to entered manually into chosen database by research assistant. * 100% of data entries will be checked by project specialist for accuracy. * a total of 218 participants will be recruited to partake in the control condition group a or group b of the intervention. * because of the exploratory nature of the study, power calculations were not used to determine sample size. * group x time analyses will compare changes in knowledge, attitudes and self efficacy before and after exposure to the videos in the entire sample; and in the subsample followed for 2 months, compare baseline to 2-month followup changes in knowledge, attitudes, self efficacy, mindfulness and stress related measures as well as behavior change in food choices during grocery shopping.

Eligibility criteria:
inclusion criteria: * identify as a hispanic woman * ages: 18-55 years * responsible for buying groceries for family * language use: ability to speak, read and write english or spanish * resident in the usc's health sciences campus and university park campus neighborhoods exclusion criteria: * none

Keywords: public health community obesity hispanic women nutrition mindfulness and stress food shopping
viscoat versus visthesia. a comparative study of post-cataract endothelial cell loss

Conditions: Cataract

Summary: objective of this study is the comparative assessment of the beneficial impact of the viscoat viscoelastic (ovd) and visthesia ovd on endothelial cells and corneal edema following torsional-ip cataract extraction surgery. participants will be recruited from the cataract service of the university hospital of alexandroupolis (uha) in a consecutive-if-eligible basis. eligibility criteria include diagnosis of senile cataract with stage 3 nuclear opalescence according to the lens opacities classification system iii (locs-3) grading scale. by means of a custom computer randomization program all participants will randomly populate two study groups according to the ovd used (ie. viscoat or visthesia).


Eligibility criteria:
inclusion criteria: * diagnosis of senile cataract with stage 3 nuclear opalescence according to the - lens opacities classification system iii (locs-3) grading scale exclusion criteria: * endothelial cell count less than 1900, * glaucoma, * iop-lowering medications, * former incisional surgery, * former diagnosis of corneal disease, * diabetes or autoimmune diseases

Keywords: cataract viscoelastic (ovd) technology endothelial cell count endothelial cell pattern central corneal edema
an observational, multicenter study to evaluate the safety and effectiveness of hetrombopag in patients with itp or aa

Conditions: Primary Immune Thrombocytopenia; Aplastic Anemia

Summary: this is a multi-center, observational study in patients with immune thrombocytopenia (itp) or aplastic anemia(aa) designed to describe the real-world safety and effectiveness of hetrombopag and assess the patterns of drug utilization to add to the knowledge base regarding the use of hetrombopag in routine medical practice. patients eligible for participation will, as part of their routine medical care, be receiving hetrombopag for the treatment of itp/aa

this is a multi-center, observational study in patients with itp/aa designed to describe the real-world safety and effectiveness of hetrombopag and assess the patterns of drug utilization to add to the knowledge base regarding the use of hetrombopag in routine medical practice. patients eligible for participation will, as part of their routine medical care, be receiving hetrombopag for the treatment of itp/aa the scope of the study is to collect both retrospective and prospective data. the main part of the study will be prospective collecting data on usage, effectiveness, safety and patient-reported outcomes whereas the retrospective part will consist of collection of information on previous treatments, reason for treatment switch and, if applicable, hetrombopag treatment prior to enrollment. the retrospective data collection will be based on the information available in the patient's medical records. data will be collected for up to 12 months prior to hetrombopag treatment start. prospective data will be collected at routine clinical visits throughout the study. patients will be followed for 24 months and will be enrolled until their first scheduled visit after 24 months of enrollment, or until early termination, whichever occurs first.

Eligibility criteria:
inclusion criteria: * 1.established and well documented itp diagnosis * 2.patient is treated with, or at enrollment prescribed hetrombopag for itp. decision to initiate treatment shall be made by the treating physician and independently from the decision to include the patient in the study. * 3.signed and dated informed consent provided by the patient before any study-related activities are undertaken * 4.willing and able to comply with protocol requirements exclusion criteria: * enrollment in a concurrent clinical interventional study

Keywords: hetrombopag
adaptive intervention to maximize colorectal screening in safety net populations

Conditions: Colorectal Cancer

Summary: the goal of this study is to find the best ways to increase colorectal cancer (crc) screening.

colorectal cancer is preventable and curable but is still the second most common cause of cancer death in the u.s. minorities and those with low income have more crc than middle and high income whites.. they also get fewer crc screening tests. low knowledge of crc screening may, in part, drive this lower test use. we need new ways to improve crc screening in primary care clinics where many minority and uninsured patients receive health care.

Eligibility criteria:
inclusion criteria: * have a home address and access to a working telephone * pass mini-cog assessment exclusion criteria: * fit (fecal immunochemical test) test within 1 year, sigmoidoscopy or barium enema within 5 years, or colonoscopy within 10 years * acute medical illness, * current gi bleed * history of adenomatous polyps * colorectal cancer * 1st degree relative with crc \< age 60 years * inherited polyposis/non-polyposis syndrome * inflammatory bowel disease * another household member enrolled in the study

Keywords: cancer screening colon cancer colon cancer screening