Kornimate/medical-research-clean huggingface dataset:
red palm olein on inflammation and gut health

Conditions: Diet; Healthy

Summary: a parallel intervention was conducted to test the effect of consuming diets enriched with red palm olein (rpoo), extra virgin coconut oil (evco) and extra virgin olive oil (evoo; positive control) in centrally obese individuals over a 12-week period. following the screening of the subjects' health status, including their biochemical and lipid profiles, the subjects completed a 12-week dietary intervention. both fasting blood and urine samples were collected at baseline (day 0) and endpoint (week 12); measurements were taken in duplicates. all data collected were blinded to the investigators by an independent third party until the completion of the analysis.

the study was conducted according to the guidelines laid down in the declaration of helsinki. all subjects gave informed consent prior to the commencement of the study. a parallel intervention was conducted to test the effect of consuming diets enriched with red palm olein (rpoo), extra virgin coconut oil (evco) and extra virgin olive oil (evoo; positive control) in centrally obese individuals over a 12-week period. following the screening of the subjects' health status, including their biochemical and lipid profiles, the subjects completed a 12-week dietary intervention. both fasting blood and urine samples were collected at baseline (day 0) and endpoint (week 12); measurements were taken in duplicates. all data collected were blinded to the investigators by an independent third party until the completion of the analysis. the efficacy of the blinding procedure was assessed by evaluating the compliance of participants using the visual analogue scale to the experimental diets. statistical analysis was conducted independently by a statistician not involved in the conduct of the study.

Eligibility criteria:
inclusion criteria: * aged 25-45 years * waist circumference ≥ 90 cm for men and ≥ 80 cm for women exclusion criteria: * bmi ≤ 18.5 kg/m2 * medical history of cardiovascular diseases * positive for diabetes or dyslipidemia * diagnosed with chronic illness * plasma total cholesterol \> 6.5 mmol/l * triacylglycerol \>4.5 mmol/l * on antihypertensive or lipid-lowering medication * lactating * pregnant * smoking

Keywords: red palm olein extra virgin coconut oil extra virgin olive oil high sensitivity c-reactive protein inflammation obesity
stepping stones and creating futures intervention trial

Conditions: IPV; Sexual Violence

Summary: this study evaluates whether the behavioural/structural interventions of stepping stones and creating futures can reduce the incidence of intimate partner violence in urban informal settlements amongst young people. half the participants will receive the interventions, while the other half will be in a control wait-list, only receiving the intervention after final data collection.


Eligibility criteria:
inclusion criteria: * normally resident in informal settlement cluster * not formally employed * able to communicate in main study languages (english, isizulu, ixhosa) exclusion criteria: * under 18 * mental deficit (learning difficulty, mental illness or substance abuse)

Keywords: informal settlements poverty
staging system for chronic symptomatic pilonidal sinus disease

Conditions: Pilonidal Sinus

Summary: a staging system was defined based on morphological extent of disease (stage i to stage iv for primary disease, and stage r for recurrent disease). specific surgical technique was used for each stage. demographics, perioperative data, short-term and long-term outcomes were evaluated according to the disease stage.

the collected data of patients who underwent surgery for the treatment of pilonidal sinus disease prior to june 2011 were analyzed. following this analysis, a staging system was defined based on morphological extent of disease (stage i to stage iv for primary disease, and stage r for recurrent disease). specific surgical technique was used for each stage. "pit-picking" technique was performed under local anesthesia on an outpatient basis in stage i and stage iia patients. for stage iib and stage iii patients, the bascom cleft lift /modified bascom cleft lift techniques were performed. for stage iv patients, the rhomboid excision with the limberg flap technique was used. demographics, perioperative data, short-term and long-term outcomes were evaluated according to the disease stage.

Eligibility criteria:
inclusion criteria: * individuals with symptomatic pilonidal sinus disease. exclusion criteria: * \<18 y * pilonidal sinus disease which identified incidentally and which presented with acute abscesses were not included to the staging system. * patients who were treated without the use of the suggested algorithm were excluded from the analysis.
are acceptance and commitment related to treatment response in chronic low back pain

Conditions: Low Back Pain

Summary: the main objective of this study is to evaluate whether acceptance (measured by the aaq-ii questionnaire) is prognostic of algo-functional changes measured by the oswestry disability index, odi) at 6 months.

the secondary objectives are: a. to search for correlations between the acceptance score (aaq-ii questionnaire) and scores for coping (csq), avoidance (fabq), understanding (bbq), anxiety and depression (hads) and quality of life (sf-12) at baseline. b. to describe the kinetics of changes in various parameters (acceptance, coping, avoidance, understanding, anxiety and depression, quality of life, odi) over 6 months. c. to evaluate the agreement between two methods of questionnaire presentation: paper collection versus collection by tablet pc.

Eligibility criteria:
inclusion criteria: * the patient has been informed about the study, and is not opposed to the study * the patient must be insured or beneficiary of a health insurance plan * the patient is available for 6 month of follow-up * the subject has chronic back pain that is not post-operative in nature and that has lasted for more than 3 months * the subject accepts the re-education curriculum. exclusion criteria: * the patient is participating in another study * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * the patient refuses to participate * it is impossible to correctly inform the patient * the patient is pregnant, parturient, or breastfeeding * the subject has a history of chronic obstructive pulmonary disease, cardiovascular disease, rheumatoid arthritis, lupus, spondylitis or neoplastic disease. * patient currently under psychological treatment
closure vs non closure of rectus muscle at cesarean section 5 year study

Conditions: Intraperitoneal Adhesions After Rectus Muscles Approximation

Summary: approximation of both recti during lower segment cesarean section may be an important step to lower incidence of intraabdominal adhesions . peritoneal adhesions are of major medical importance and are associated with clinical problems such as chronic pain and infertility.

all patients included in the study should be had the operative history of the previous cesarean section and were done in the cairo university and divid them into 2 groups. 1st group were both recti approximated while the second group were closed without approximating both recti. all patients will be subjected to lower segment cesarean segment to assess the intraperitoneal adhesions, mean operative time, mean hospital stay, postoperative distension, bowel sounds, postoperative infections and morbidity

Eligibility criteria:
inclusion criteria: * all patients of first lower segment cs at kasr al ainy with previous recorded data including operative data, postoperative data including complications. all patients included in the study are elective cesarean section at 38 weeks of gestation exclusion criteria: * no history of infection or medical disease * no history of previous laparotomies * no history of pregnancy complications * patients noted to have intraperitoneal adhesions in first cesarean section
effect of a pre heparin coated dialysis filter on coagulation during hemodialysis

Conditions: Renal Failure

Summary: the purpose of this study is to determine whether the heparin-coated dialysis filter is superior to a conventional filter during hemodialysis in twelve stable, chronic hemodialysis (hd) patients. the antithrombogenic properties of the heparin-coated dialysis filter and of the conventional filter will be compared by means of statistical tests.

in the present study twelve chronic hemodialysis (hd) patients will be included. exclusion criteria are use of acetylsalicylic acid and/warfarin, clinical signs of infection and disseminated malignant disease. for each patient four hd sessions will be investigated; alternating with use of the pre-heparin-coated filter or the conventional filter. dalteparin is reduced to 50% of the conventional dose and is given as one single bolus dose at start of hd. the venous drip chamber will be visually inspected for evaluation of clot score during each hd session. the filter will be visually inspected for clot score at the end of each session. blood specimens will be drawn systematically during each hd session to evaluate platelet and coagulation activity as well as anti factor xa activity, haematology and urea/creatinine to evaluate dialysis effect. the antithrombogenic properties of the pre-heparin-coated filter and the conventional filter will be compared by means of statistical tests. the hypothesis is that the pre-heparin-coated filter induces significantly less clot score in the extracorporeal system during hemodialysis and also significantly less intravascular activation of the coagulation system compared to the conventional filter.

Eligibility criteria:
inclusion criteria: * stable hd patients of at least 18 years of age. * hd treatment for at least one month. * dialysis time at least 4 hours three times per week. * stable hemoglobin value of at least 11 g/dl during the last 4 weeks. exclusion criteria: * use of warfarin and/or acetylsalicylic acid. * disseminated malignant disease. * clinical signs of infection.

Keywords: hemodialysis anticoagulation clotting coagulation dalteparin clotting in the extracorporeal system during hd antithrombogenic property of evodial hd filter anticoagulation during hd
pragmatic randomized controlled trial of non-pharmacological treatment for lumbar disc herniation : a pilot study

Conditions: Lumbar Disc Prolapse With Radiculopathy

Summary: this is a 2-arm parallel pragmatic randomized controlled trial that will compare non-pharmacological treatment with pharmacological therapy for lumbar disc herniation.

participants who voluntarily signed informed consent form and eligible for the study were randomly assigned in a 1:1 ratio (15:15) for non-pharmacological treatment and pharmacological treatment group. participants of each group will receive twice a week for total 8 weeks of intervention. this is a pragmatic randomized controlled trial, so physicians will have medical decision making according to each participant's conditions and choose the specific intervention and dosage of pharmacological and non-pharmacological treatment.

Eligibility criteria:
inclusion criteria: 1. numeric rating scale (nrs) score of radiating pain 5 or more for recent 3 serial days. 2. onset time of radiating pain occurred within 12 weeks. 3. radiologically diagnosed with lumbar disc herniation in lumbar spine magnetic resonance imaging (l-spine mri) 4. 19-70 years old 5. participants who agreed and signed informed consent form exclusion criteria: 1. spine metastasis of cancer, acute fracture of spine, or spine dislocation 2. progressive neurologic deficits or severe neurologic deficits 3. soft tissue diseases that can induce low back pain(ie. cancer, fibromyalgia, rheumatoid arthritis, gout,etc) 4. presence of chronic underlying disease which can interfere the efficacy or interpretation (ie. stroke, myocardial infarct, kidney disease, dementia, diabetic neuropathy, epilepsy, etc) 5. concurrent use of steroids, immunosuppressants, orpsychotropic medications or any other medication that can interrupt the study result 6. hemorrhagic disease, severe diabetes or taking anticoagulant drug 7. participants who took nsaids or pharmacopuncture within 1 week 8. pregnant or lactating women 9. participants who had undergone lumbar surgery within 3 months 10. participants who had participated in other clinical trial within 1 month, or have plan for participation in other trial during follow up period of this trial 11. participants who can not write informed consent 12. participants who is difficult to participate in the trial according to investigator's decision
phase 1b study of verve-201 in patients with refractory hyperlipidemia

Conditions: Hypercholesterolemia

Summary: vt-20101 is an open-label, phase 1b, single-ascending dose study that will evaluate the safety of verve-201 administered to patients with refractory hypercholesterolemia. verve-201 uses base-editing technology designed to inactivate the expression of the angptl3 gene in the liver and lower circulating low-density lipoprotein cholesterol (ldl-c). this study is designed to determine the safety and pharmacodynamic profile of verve-201 in this patient population.


Eligibility criteria:
inclusion criteria: * refractory hypercholesterolemia * females of non-childbearing potential or males exclusion criteria: * active or history of chronic liver disease * current treatment with monoclonal antibody targeting angptl3 or prior treatment within specified timeframe * clinically significant or abnormal laboratory values as defined by the protocol

Keywords: verve-201 gene editing base editing refractory hypercholesterolemia cardiovascular disease angptl3
chg0521 oral coating in patients with solid tissue tumor/recurrent/metastatic tscc

Conditions: Squamous Cell Carcinoma; Squamous Cell Carcinoma of the Oral Cavity

Summary: this is a prospective single-arm loading test study of chg0521 oral coating in patients with solid tissue tumor/recurrent/metastatic tscc


Eligibility criteria:
inclusion criteria: * 1. age range: 18-80 years, encompassing both males and females. 2. confirmation of tongue squamous cell carcinoma through histopathology or cytology is required. 3. patients who are deemed unsuitable for surgery, have surgical indications but decline the treatment, or experience relapse and metastasis after surgery with no further surgical options available. 4. no concurrent use of other traditional chinese medicine orally or externally within the past 3 months. 5. presence of at least one measurable lesion according to recist 1.1 criteria. 6. eastern cooperative oncology group (ecog) performance status score of 0 or 1. 7. expected survival time should be equal to or greater than 3 months. 8. liver function indicators: total bilirubin level ≤1.5 times the upper limit of normal (uln), ast and alt levels ≤2.5 times uln (or ≤5 times uln in case of liver metastasis). 9.renal function indicators: serum creatinine (cre) ≤1.5×uln and calculated creatinine clearance (using cockcroft-gault formula) ≥60 ml/min. 10.the functionality of vital organs should be essentially normal. exclusion criteria: * 1. patients with tongue squamous cell carcinoma who have undergone tumor resection without any residual tumor; 2. patients with a known allergy to any therapeutic ingredient or a history of hypersensitivity or allergic constitution; 3. patients who have experienced a severe infection within 4 weeks prior to the first use of the investigational drug, and whose common adverse reaction criteria were graded as \&gt;2; 4. patients with a history of immune deficiency, organ transplantation, or allogeneic bone marrow transplantation; 5. patients currently enrolled in another concurrent clinical study; 6. pregnant and lactating women.
the canadian respiratory research network long covid-19 study

Conditions: SARS-CoV-2 Infection; Post-acute Sequelae of SARS-CoV-2

Summary: preliminary studies suggest that covid-19 causes long-term lung damage, even in young, otherwise healthy people who did not need to go to hospital or the icu. we seek to know how common long-term lung damage after covid-19 is, who is most affected by it and what the effects of this damage are on other important aspects of people's lives. we plan to study a large sample of people with a history of covid-19 infection from across canada-some who needed hospitalization but most who did not. through online questionnaires, we will determine their respiratory symptoms, quality of life and medical history. then we will invite them to one of our thirteen canadian testing centres to have special, thorough breathing tests. we hypothesize that covid-19 leaves a significant proportion of people with measurable respiratory impairment. the information we learn about the effect of covid-19 on the lungs will help patients and health care providers manage it better. it will also reveal how different covid-19 variants affect the lungs. we will use this new knowledge to write a formal guide on what respiratory monitoring and testing should be done after covid-19 infection. this will ensure that people affected by covid-19 get the care they need to maintain their lung health.

we will prospectively recruit a representative, random sample of adult (age ≥ 18), community-dwelling patients, who have had a positive pcr test for covid-19 infection and symptomatic infection five to 12 months previously. this cross-sectional, observational study will have two phases: 1. screening: screening for eligibility 2. observation period: 1. online / telephone visit: all participants will complete a series of questionnaires (either online or by phone with the assistance of research personnel). in the questionnaires they will be asked about respiratory symptoms (the primary outcome), baseline participant data, burden of respiratory symptoms, overall quality of life, mental health issues as well as physical and psychological trauma from covid-19. 2. in-person visit: all participants will complete pulmonary function testing including oscillometry. the study of covid-19 infection and its long-term effects is constantly evolving. over the course of this research study, new knowledge may become available that may lead to changes in the study's outcome measures.

Eligibility criteria:
inclusion criteria: * aged ≥18 * community dwelling * first occurrence of a positive diagnostic test for sars-cov-2 infection (i.e., pcr or rapid antigen test, including at-home rapid antigen test) and symptomatic infection 5-12 months previously * consent provided * willing and able to go to study site for pulmonary function testing including oscillometry exclusion criteria: - not able to communicate with our research personnel (themselves or through a translator)
lavage and suction of the right upper quadrant to reduce post laparoscopic shoulder pain

Conditions: Shoulder Pain

Summary: the use of laparoscopy in gynecologic surgery has been well established to decrease morbidity, blood loss, hospital stay, and post-operative pain when compared to traditional open abdominal surgery. however, the laparoscopic technique is associated with post-operative shoulder pain. we hypothesize that a combination of intraperitoneal saline lavage and active suction removal of carbon dioxide gas from the right upper quadrant of the abdomen will decrease incidence of post-laparoscopic shoulder pain when compared to passive exsufflation of carbon dioxide gas.


Eligibility criteria:
inclusion criteria: * english speaking patient * female * age 18-75 * must undergo laparoscopic surgery * willing to participate in the study exclusion criteria: * male patients * under 18 or older than 75 * laparoscopic procedures that get converted to laparotomy * intraoperative hemorrhage more than 500 cc * patients with active joint disease * history of shoulder surgery * intraoperative laceration to the liver * malignancy * long term daily narcotic use * chronic right upper quadrant/ shoulder pain * pregnancy * history of dementia, alzheimers, stroke or other condition causing altered mental status

Keywords: post laparoscopic shoulder pain active suction lavage and suction right shoulder pain post operative shoulder pain
a retrospective chart review of mabthera (rituximab) treatment in rheumatoid arthritis (ra) participants in australia

Conditions: Rheumatoid Arthritis

Summary: this is a cross-sectional, observational study examining the factors leading to the therapeutic decision to use mabthera (rituximab) in participants with ra. routine rheumatology clinical practice data of participants who are being or have been treated with rituximab for ra will be collected and analysed in this chart review.


Eligibility criteria:
inclusion criteria: * greater than or equal to (\>=) 18 years of age at the time of data collection * ra diagnosed by a rheumatologist * treatment with rituximab for ra exclusion criteria: * participants whose primary diagnosis and indication for rituximab treatment is a condition other than ra * participants who have been treated with an experimental agent for ra which is not currently approved for the treatment of ra in australia
analysis of related risk factors of hypoglycemia consciousness disorder

Conditions: Hypoglycemia

Summary: objective to explore the high risk factors and inducements of consciousness disorder in patients with hypoglycemia, and to conduct a retrospective study.


Eligibility criteria:
inclusion criteria: symptoms of hypoglycemia such as palpitation, sweating and fatigue were found at the time of treatment. at the same time, the blood glucose of non-diabetic patients was less than 2.8mmol/l, and the blood glucose of diabetic patients was less than 3.9mmol/l exclusion criteria: exclusion criteria: although there were hypoglycemia symptoms at the time of treatment, the blood glucose of non-diabetic patients was more than 2.8mmol/l, and the blood glucose of diabetic patients was more than 3.9mmol/l.