Kornimate/medical-research-clean huggingface dataset:
clinical outcomes following total joint replacement with corin prostheses: corin metafix collared stem

Conditions: Osteoarthritis, Hip

Summary: assessment of the clinical performance and survivorship of the corin total hip system with trinity™ cup metafix™ collared stem in a prospective study. the primary endpoint of the study is to evaluate the 3-year survivorship and clinical performance of the corin total hip system using trinity™ cup and metafix™ collared stem. additionally, the study follow up will continue until 10 years for subjects who consent to do.

the primary objective is the 3-year survivorship of the study devices. the secondary objectives include: * the improvement of clinical outcomes: * oxford hip score (ohs) up to 10-year follow-up * harris hip score (hhs) up to 10-year follow-up * hip disability and osteoarthritis outcome score (hoos) up to 10-year follow-up * safety performance monitoring including hip- and device-related aes and the revision rate up to 10-year follow-up

Eligibility criteria:
inclusion criteria: * patients requiring a thr exclusion criteria: -
giardia induced fatigue and functional gastrointestinal diseases

Conditions: Chronic Fatigue Syndrome

Summary: a giardiasis outbreak in bergen has given us the opportunity to approach two basic research questions of national and global importance: * studying the pathoimmunology of giardiasis in a natural setting, and following the genetic and immunological responses leading to recovery or persistent disease and sequelae. * studying the two disease entities fgid and cfs when induced by acute giardiasi and their risk factors. * interventional cognitive behavioural therapy is the only intervention documented to have significant effect on cfs outcome, and conventional cognitive behavioural therapy will be compared to a psycho-educational programme in the format of a randomised controlled trial.


Eligibility criteria:
inclusion criteria: * problems with fatigue of any severity after giardia infection

Keywords: cfs giardia fatigue cognitive behavioural therapy cbt chronic fatigue syndrome
a trial evaluating the role of sildenafil in the treatment of fetal growth restriction

Conditions: Fetal Growth Retardation

Summary: this is a randomized controlled trial to evaluate the effect of sildenafil on doppler velocity indices of the umbilical arteries in patients with placental insufficiency and fetal growth restriction, and if sildenafil can improve fetal and neonatal outcomes in those patients.


Eligibility criteria:
inclusion criteria: * pregnant women, singleton pregnancy, gestational age 24-34 weeks, with * fetal growth restriction. * intact membranes. * abnormal umbilical artery doppler waveforms. * fetal abdominal circumference at or below the tenth percentile. * normal venous fetal doppler exclusion criteria: * undetermined gestational age. * intrauterine infection. * high risk for aneuploidy (e.g. maternal age ≥40 years, detected congenital fetal anomalies in the current or previous pregnancies). * maternal cardiovascular morbidity. * users of any vasodilator agents. * known allergy to sildenafil citrate

Keywords: sildenafil fetal growth restriction umbilical artery doppler
evaluation of intrafractional motion of liver tumors using markers

Conditions: Tumor; Effects of; Movement; Radiation; Lesion

Summary: radioopaque fiducial markers or electro-magnetic transponders will be implanted into or in close proximity of the tumor. during a radiotherapy treatment session image and/or signal acquisition will be performed by ultrasound, computed tomography, magnetic resonance imaging or by specialized signal detectors the data will help to characterize tumor and organ motion during one treatment session which may in fact have impact on dose distribution

with the development of more conformal and precise radiation techniques such as intensity-modulated radiotherapy (imrt), stereotactic body radiotherapy (sbrt) and image-guided radiotherapy (igrt), patients with hepatic tumors could be treated with high local doses by sparing normal liver tissue. however, frequently occurring large hcc tumors are still representing a dosimetric challenge in spite of modern high sophisticated rt modalities. this interventional clinical study has been set up to evaluate the value of different fiducial markers, and to use the modern imaging methods for further treatment optimization using physical and informatics approaches.radioopaque fiducial markers or electro-magnetic transponders will be implanted into or in close proximity of the tumor. during a radiotherapy treatment session image and/or signal acquisition will be performed by ultrasound, computed tomography, magnetic resonance imaging or by specialized signal detectors the data will help to characterize tumor and organ motion during one treatment session which may in fact have impact on dose distribution

Eligibility criteria:
inclusion criteria: * indication for high precision radiotherapy of primary and secondary liver tumors using igrt (image-guided radiotherapy) * age ≥ 18 years of age * ability of subject to understand character and individual consequences of the clinical trial * written informed consent (must be available before enrolment in the trial) exclusion criteria: * refusal of the patients to take part in the study * medical reasons impeding marker implantation or igrt for treatment of liver tumors. * non-compliance of patients
dachaihu decoction compound and rhubarb single medicine in the treatment of acute pancreatitis

Conditions: Acute Pancreatitis

Summary: a large number of clinical studies have shown that oral administration, external application or enema of chinese medicine can promote the recovery of gastrointestinal function and the absorption of pancreatic inflammation. the aims of the study is to explore the application of dachaihu decoction compound (ddc)and rhubarb single medicine (rsm) in the treatment of acute pancreatitis.


Eligibility criteria:
inclusion criteria: * age from 18 to 65 years old * meet the diagnostic criteria of western medicine for acute pancreatitis, within 48 hours of onset * consent of the subjects, who sign the informed consent form exclusion criteria: * women who are pregnant or breastfeeding * acute abdomen such as organic intestinal obstruction, gastrointestinal perforation, purulent cholangitis, etc. * patients with a history of severe heart, liver, kidney and other important organ diseases * patients with mental illness and malignant tumors * people who have allergies, or are allergic to a certain drug ingredient

Keywords: acute pancreatitis dachaihu decoction compound rhubarb single medicine
assessing the impact of tixel treatment of periorbital wrinkles on dry eye symptoms and signs

Conditions: Dry Eye; Dry Eye Syndromes

Summary: pilot study where effect of standard tixel treatment as used for periorbital wrinkles would be assessed on dry eye disease symptoms and signs

safety assessment will be asses via ae/sae reporting and impact assessment of the effect of treatment on dry eye symptoms and signs through multiple test indicate dry eye

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * mild to moderate periorbital wrinkles * osdi score of at least 23 * noninvasive tear film break up time (nikbut) ≤ 10 seconds * no other eye or skin or immune problems * willing and able to provide written informed consent. * willing to participate in all study activities and instructions. exclusion criteria: * pregnancy and/or breastfeeding * lesions in the periorbital area * acute severe blepharitis * acute conjunctivitis * other concomitant anterior eye disease * has undergone outdoors/sunbed tanning during the last 4 weeks * is unwilling to follow the tixel aftercare instructions after each of the three tixel treatments. * active herpes simplex or tendency for herpes simplex in the periorbital area (meaning the subject has had the condition previously). * current skin cancer, malignant sites and/or advanced premalignant lesions or moles in the treatment area. * an impaired immune system condition or use of immunosuppressive medication. * collagen disorders, keloid formation and/or abnormal wound healing. * previous invasive/ablative procedures in the areas to be treated within 3 months prior to initial treatment or plans for such treatment during the course of the tixel2 device treatment, or before complete healing of such treatments has occurred. * any patient who takes or has taken any medications (including via topical application), herbal treatment (oral or topic), food supplements or vitamins, which may cause fragile skin or impaired skin healing during the last 3 months. * any patient who has used oral isotretinoin (accutane® or roaccutan®) within 3 months prior to treatment or less. * any patient who has a history of bleeding coagulopathies or use of anticoagulants. * any patient who has tattoos or permanent makeup in the treated area. * any patient who has burned skin, blistered skin, irritated skin, or sensitive skin in any of the areas to be treated. * any patient who underwent thread lifting of the area to be treated in the last 3 months.
colors, can they reduce the dental anxiety

Conditions: Anxiety; Anxiety State; Tooth Extraction Status Nos

Summary: the investigator's aim in this study was to evaluate the preoperative anxiety and pain felt during the operation due to exposure to green, red, and blue light. for this purpose, the participants will wear colored glasses before the operation. the investigator will evaluate the patient's anxiety change and the pain she/he feels during the procedure.


Eligibility criteria:
inclusion criteria: * asa 1 and asa 2 patient population * not having had a third molar surgery before * volunteer to participate in the study exclusion criteria: * dental phobia * patients who will be treated under general anesthesia * refusing the measurements * not filling out the vas * encountering complications during surgery * operations lasting more than 45 minutes
comparison between different horizontal ridge augmentation techniques

Conditions: Atrophic Ridge

Summary: sixteen patients were selected from the outpatient clinic of the oral and maxillofacial surgery department, faculty of dentistry, mansoura university for replacement of missed single tooth / teeth in posterior atrophic mandible by dental implant. patients' grouping: patients were divided randomly into two equal uniform groups as follow: group i: eight implants were placed in patients of missing single tooth / teeth in posterior mandible with subsequent horizontal ridge augmentation by decompression technique. group ii: eight implants were placed in patients of missing single tooth / teeth in posterior mandible with subsequent horizontal ridge augmentation by ridge splitting technique using piezosurgery. all patients were evaluated clinically and radiographically at regular time interval immediately, 6 and 12 months after surgery.


Eligibility criteria:
inclusion criteria: * patient's cooperation, motivation and good oral hygiene. * patient medically free from systemic diseases that absolutely contraindicate implant surgery. * moderately atrophic posterior mandible (horizontal alveolar dimension is not more than 4 mm at the crest), with minimum 10 mm vertical height. * patients prepared to comply with the follow-up and maintenance programme. * free from history of bruxism / parafunctional habits. exclusion criteria: * patients with local pathological disease such as cyst, tumor at the planned surgical site. * pregnant patients. * heavy smoker patients.
impact of folfirinox chemotherapy in iv stage colorectal cancer patients previously exposed to irinotecan, fluoropyrimidine and oxaliplatin

Conditions: Colorectal Cancer Stage IV

Summary: the purpose of this work is to verify prospectively what the rate of response after triple chemotherapy with mfolfirinox in patients in iv stage of colorectal cancer who have already failed after at least two lines of dual combinations with fluoropyrimidine, oxaliplatin, irinotecan and anti-egfr if wild-type ras. currently at icesp, patients are frequently re-exposed in third line to double combinations.

single-arm phase ii study. the chemotherapy regimen with mfolfirinox will be administered every 14 for 4 cycles, after evaluation of tumor response, you can maintain treatment until disease progression. the folfirinox regimen, as well as the drugs used (oxaliplatin, 5-fluorouracil, leucovorin and irinotecan) is already indicated in the package insert for the treatment of colorectal cancer. if treatment is discontinued after cycle 4 with the patient responding, for response maximum or unmanageable toxicity, it is suggested to maintain imaging control every 60 days (7-day window) until disease progression. this interval is already commonly used for patients with metastatic disease who are on treatment pause. treatment in progression of illness will be at the discretion of the treating physician. cancer patients undergoing chemotherapy routinely perform evaluation of organ functions and cea, as well as clinical evaluation before each cycle of treatment

Eligibility criteria:
inclusion criteria: * diagnosis of metastatic colon/rectal adenocarcinoma, with measurable by recist v. 1.1 * disease progression to at least two lines of chemotherapy with chemotherapy regimens that contain fluoropyrimidine, irinotecan and oxaliplatin * patients with ras research in tumor sample with result wild animals must have previously received anti-efgr therapy. * ecog (eastern cooperative oncology group) 0 or 1 * availability of tumor material for molecular analysis * hb \> 8, neutrophils \> 1,500 and plq \> 100,000 * adequate kidney and liver function exclusion criteria: * active neoplasm with other primary site, except in situ tumors * contraindication to treatment with fluoropyrimidine, oxaliplatin and irinotecan, including previous unmanageable g3 or greater toxicities, in previous exhibitions. * presence of comorbidities that, according to the investigator's assessment, may compromise participant safety * prior exposure to the folfirinox regimen * pregnant or lactating women * total bilirubin above 1.5mg/dl * hepatic transaminases greater than 3 times the upper limit of normality

Keywords: colorectal cancer
a mobile phone sms intervention to increase retention in hiv care among hiv-positive msm in peru (weltel peru)

Conditions: Retention in Care; Hiv

Summary: we will use a web-based system in order to deliver a text messaging-based intervention and assess the efficacy to increase retention in hiv care among hiv+ gay men in peru.

we will determine the efficacy of the sms-based intervention delivered through a web-based system for increasing retention in hiv care when compared with standard-of-care. we will perform a randomized controlled trial. the main outcome will be retention in hiv care within 1 year after enrollment. participants will be categorized as retained if they attend three medical appointments for hiv care that are separated by 90 days within a one-year period (at the study clinic). otherwise they will be classified as not retained. the follow-up period will last 6 months. we will identify and recruit 208 hiv+ msm over a 12-month period at the research site. healthcare providers at the clinic will be trained to assess eligibility and obtain consent for this study. after enrollment, the recruiter, who will be masked to the group assignment, will obtain consent and give instructions to all participants on how they should interact if they start receiving sms (text messages). participants will be randomized after signing the consent form. they will be assigned a study id and randomly assigned to the intervention or control arm, 1:1 ratio using computer generated random numbers. allocations will be sealed in individual, sequentially numbered opaque envelopes. the trained providers in charge of delivering the intervention will be informed when a new participant in the intervention arm is enrolled. because of the nature of the study, healthcare providers and participants will not be masked to group assignment during the delivery of the intervention. participants allocated to the intervention arm will have their phones registered into the platform.

Eligibility criteria:
inclusion criteria: 1. be men who have sex with men; 2. be 18 years or older; 3. have been diagnosed hiv positive; 4. own a cell phone which can send and receive text messages; 5. reside in lima, peru; exclusion criteria: 1) be enrolled in an interventional trial using text messages.
recurrent collection by medical student in general medicine

Conditions: General Practice

Summary: the project for the recurrent collection of data from interns in general medicine is a formalized description of the consultations attended by medical students during their outpatient training. this formalization uses the international classification of primary care. this project aims to create a research network between general medical interns, mainly for their thesis, which pools their observations in a database accessible to all participants.


Eligibility criteria:
inclusion criteria: * consultation of his general practitioner exclusion criteria: * none

Keywords: citizen science medical student icpc
the efficacy and safety of a hybrid hemostatic device (clearcoajet)

Conditions: Colonic Polyps

Summary: the clearcoajet is a new hemostasis device with a hybrid function (coagulation + injection) and is developed to provide effective coagulation, injection, and marking around lesions without changing devices during the endoscopic procedure. in this study, the investigators examine the hemostatic effect of clearcoajet on intraprocedural bleeding during endoscopic mucosal resection or endoscopic submucosal dissection for colorectal sessile polyps or lateral growth tumors larger than 1.5 cm. the investigators also aim to compare the delayed bleeding and recurrence rates between the clearcoajet group and the control group.


Eligibility criteria:
inclusion criteria: * patients with colorectal sessile polyps or lateral growth tumors larger than 1.5 cm exclusion criteria: * pedunculated polyp * patients with coagulopathy
analgesic effect of m-tapa and tapb on laparoscopic cholesistectomy

Conditions: Post Operative Pain

Summary: cholecystectomy is the most frequently performed abdominal surgery in developed nations, with laparoscopic cholecystectomy being recognized as the gold standard technique for treating gallstones. the efficacy of tap block for pain relief has been well-documented following laparoscopic cholecystectomy procedures. recently, m-tapa block has emerged as an alternative analgesic technique for abdominal surgeries. this study aims to evaluate and compare the effectiveness of these two analgesic methods in managing postoperative pain after laparoscopic cholecystectomy.

cholecystectomy is the most commonly performed abdominal surgery in developed countries, with laparoscopic cholecystectomy regarded as the gold standard technique for gallstone treatment. postoperative pain following laparoscopic cholecystectomy is influenced by several factors, making it a complex and predominantly visceral pain. these factors include phrenic nerve irritation due to co2 insufflation, abdominal distension, port site incisions, the effects of gallbladder removal, and individual patient characteristics. regional analgesia has gained widespread acceptance from both patients and physicians, becoming a key component of multimodal analgesia techniques. the transversus abdominis plane (tap) block has proven effective in reducing postoperative pain in surgeries such as hysterectomy, cholecystectomy, cesarean section, and colorectal procedures. the ultrasound (us)-guided modified thoracoabdominal nerve block through perichondrial approach (m-tapa) involves administering a local anesthetic to the underside of the perichondral surface. this technique provides effective analgesia for the anterior and lateral thoracoabdominal regions. the purpose of this study is to compare the efficacy of us-guided m-tapa block with tap block for postoperative analgesia following cholecystectomy.

Eligibility criteria:
inclusion criteria: * adult patients older than 18 years of age who underwent elective laparoscopic cholecystectomy under general anesthesia and were american society of * anesthesiologists (asa) i-ii-iii according to the asa risk classification. exclusion criteria: * patients who did not give consent, * patients with coagulopathy, * patients with signs of infection at the block application site, * patients using anticoagulants, * patients with local anesthetic drug allergies, * patients undergoing open surgery, * patients with unstable hemodynamics, * patients who could not cooperate during postoperative pain assessment

Keywords: laparoscopic cholecystectomy m-tapa tap
the effect of surfactant administration on cerebral oxygenation

Conditions: Respiratory Distress Syndrome; Prematurity

Summary: the purpose of this study is to assess changes in cerebral oxygenation during two different types (beractant and poractant) and two different routes (double lumen or single lumen endotracheal tube) of surfactant administration using near infrared spectroscopy (nirs).


Eligibility criteria:
inclusion criteria: clinical diagnosis of respiratory distress syndrome \<32 gestational weeks and/or \<1500 g birthweight exclusion criteria: major congenital anomalies complex congenital heart diseases

Keywords: rds surfactant cerebral oxygenation near infrared spectroscopy
cost of cancer diagnosis using next-generation sequencing targeted gene panels in routine practice

Conditions: Cancer

Summary: the aim of this study was to measure the total cost of performing next-generation sequencing (ngs) in clinical practice in france, in both germline and somatic cancer genetics. the study was performed on 15 french representative cancer molecular genetics laboratories performing ngs panels' tests. the production cost was estimated using a micro-costing method with resources consumed collected in situ in each laboratory from a healthcare provider perspective. a top-down methodology for specific post-sequencing steps was used. additional non-specific costs were also included and costs were detailed per step of the process.


Eligibility criteria:
inclusion criteria: * french genetics laboratories performing somatic and germline clinical ngs tests. exclusion criteria: -

Keywords: next-generation sequencing (ngs) cost cancer diagnosis