Kornimate/medical-research-clean huggingface dataset:
the health crisis at the healthcare professionals, careers and non-careers, a month after the containment period

Conditions: Psychology, Social

Summary: the investigator wish to study, at a distance from the lifting of confinement (1 month), whether the psychological impact on professionals in nursing and non-nursing care establishments is associated with their living context (professional and personal situation) during confinement.

the context of confinement and of the global pandemic is a major source of stress for the entire population: separation of loved ones, loss of freedom, uncertainty about the infectious status, boredom. all of these factors can cause negative mental health consequences. having little social contact was one of the factors increasing the negative psychological impact of confinement. people suffering from psychological disorders are particularly vulnerable during quarantine periods. on march 17, 2020, the french government implemented national containment measures due to the covid-19 epidemic. although the effects of containment have been studied for fragile populations, no study to date has focused on the specific population of healthcare facility staff. these caregivers have for the most part continued their professional activity, but they have been confronted with the fear of contracting or causing patients to contract covid-19. at a distance from the lifting of confinement (1 month), the investigator wish to study whether the highlighting of anxiety or depression in these healthcare professionals is associated with their context of life (professional and personal situation) during confinement

Eligibility criteria:
inclusion criteria: * nursing and non-nursing care professionals exclusion criteria: * refusal to participate * subject included in an interventional study
differential diagnostic of immune thrombocytopenia (itp) and myelodysplastic syndrome (mds)

Conditions: Immune Thrombocytopenia; Myelodysplastic Syndromes

Summary: current diagnostic criteria for immune thrombocytopenia (itp) are mainly based on the presence of low numbers of platelets, excluding other multiple causes of thrombocytopenia, including immunodeficiencies, constitutional or acquired thrombocytopenia, hypersplenism and clonal hematological disorders such as mds, disorders lymphoproliferative and acute myeloid leukemia (aml), among others. the analysis complementary tests for the diagnosis of itp include studies basic systematic hematology, together with autoimmune assays and microbiological tests, while the evaluation of bone marrow is limited to elderly patients and/or patients resistant to treatment. previous research has described the development of myelodysplastic syndrome (mds) in patients with a previous diagnosis of itp, and even the presence of mds associated with genetic background. therefore, it is conceivable fact that a percentage of cases with clinical signs of itp in the moment of appearance may actually correspond to the first stages of mds development in which bone marrow cells are not systematically evaluated in the initial presentation. the anomalous immunophenotypic patterns between multiple compartments of bone marrow cells and peripherally blood (pb) platelets have been characterized through flow cytometry. the flow cytometry currently represents an important complementary tool for diagnosis of mds that has shown great effectiveness and applicability in the differential diagnosis of non-clonal cytopenias against early mds and for the detection of stages prior to mds. besides, the flow cytometry has made it possible to detect the presence of coexisting features related to mds in patients with other malignancies hematologic conditions such as multiple myeloma, aml, and lymphocytic leukemia chronic. therefore, the immunophenotypic analysis of the cells of the bone marrow of patients with itp at the time of appearance would help to identify the cases that underlie clonal hematopoiesis mds type. in the present study it is planned a broad characterization immunophenotyping of multiple compartments of bone marrow cells and pb platelets from patients with recently diagnosed itp and investigate their morphological antecedents, in order to identify those patients who show compatible clonal hematopoietic patterns with mds evident (or at risk of development), as candidates to receive most appropriate therapeutic methods.


Eligibility criteria:
inclusion criteria: * patients aged ≥ 18 years old at diagnosis * informed consent in writing * newly diagnosed primary itp patients, or * newly diagnosed mds patients exclusion criteria: * patients who participated in a interventional thrombopoietin receptor agonists (tpo-ra) clinical trial since tpo-ra treatment initiation * patients with secondary immune thrombopenia
vaginal hysterectomy, laparoscopic hysterectomy, postoperative pain

Conditions: Postoperative Pain

Summary: the previous studies have shown that recovery after laparoscopic or vaginal hysterectomy is faster than after abdominal approach. the aim of this study is to evaluate postoperative pain after vaginal or laparoscopic hysterectomy. the primary outcome measurement is opioid consumption.


Eligibility criteria:
inclusion criteria: * age 18 -69 years * gender . female * asa status 1-3 * vaginal hysterectomy or laparoscopic hysterectomy exclusion criteria: * body mass index over 35 * diabetes mellitus * liver disease * allergies to pharmaceuticals used in the study * present use of opioids * vaginal prolapse

Keywords: pain, postoperative hysterectomy, vaginal surgery, gynecological
a trial to evaluate the efficacy of immunoglobulin plus steroid for prevention of coronary artery abnormalities in taiwanese refractory kawasaki disease (rast study)

Conditions: Kawasaki Disease; Steroid; Immuoglobulin

Summary: background: kawasaki disease (kd), most popular acquired heart disease in childhood, is characterized by diffuse vasculitis, especially on the middle-sized muscular arteries. ivig and aspirin are currently standard treatment. however, 10-15% of kd patients have poor response to such treatment and suffer from higher risk of coronary involvement. recently, combination of prednisolone and ivig has been shown effective to lower the chance of refractory to ivig treatment and subsequent coronary lesions. however, no randomized trial on the steroid efficacy was ever conducted in taiwan. aim: prospectively randomized open-label trial to evaluate the add-on effect of prednisolone in the refractory kd children. methods: for the kd patients with fever persisted or relapsed 24 hours after the ending of ivig infusion, they will be randomized into two group: ivig group (i) and ivig + prednisolone group (p). the kd patients in the p group will have in addition to ivig, oral prednisolone 2mg/kg/day for at least 5 days. the difference in the response rate and percentage of coronary involvement will be compared between i and p groups. predicted results: we plan to enroll 100 refractory kd patients, 50 patients for each group. we predict the risk of coronary involvement can be reduced from 30% to 15%.


Eligibility criteria:
inclusion criteria: * kd (kawasaki disease) patients who failed to respond to the initial ivig as those who had persistent fever that lasted for more than 24 hours (nonresponse to the initial ivig) or recrudescent fever associated with kd symptoms after an afebrile period (relapse). exclusion criteria: * kd patients, those diagnosed on or after day 9 of illness (the first illness day was defined as the day of fever onset), those with coronary artery abnormalities before enrolment, those who were afebrile before enrolment, those who had received steroids (oral, intravenous, intramuscular, or subcutaneous) in the 30 days before the study or intravenous immunoglobulin in the previous 180 days, those with concomitant severe medical disorders (eg, immunodeficiency, chromosomal anomalies, congenital heart diseases, metabolic diseases, nephritis, collagen diseases), and those with suspected infectious disease, including sepsis, septic meningitis, peritonitis, bacterial pneumonia, varicella, and influenza.
a study of all-trans retinoic acid (atra) and bryostatin in patients with acute myeloid leukemia (aml) and myelodysplastic syndrome (mds)

Conditions: Acute Myelogenous Leukemia; Myelodysplastic Syndrome

Summary: the purpose of this study is to assess the effects of the combination of all-trans retinoic acid in combination with one of two schedules of bryostatin 1 in patients with myelodysplasia and acute myelogenous leukemia.

all patients receive all-trans retinoic acid at a dose of 150 mg/m2/day and patients are randomized to one of two schedules of bryostatin 1. arm 1: bryostatin 1 is administered at a dose of 60 mcg/m2 as a 30 minute intravenous (iv) infusion on days 8 and 22. arm 2: bryostatin 1 is administered at a dose of 40 mcg/m2 as a 72 hour iv infusion starting on days 8 and 22. patients are assessed for response on day +50 with a bone marrow examination and patients with either a clinical response or stable disease receive further therapy. bryostatin 1 pharmacokinetic samples are to be drawn on days 1, 8 and 50 of each cycle.

Eligibility criteria:
inclusion criteria: * patients with aml who have failed induction chemotherapy. * patients with secondary aml * patients with aml over age 60 who are deemed not to be a candidate for chemotherapy. * patients with any subtype of mds. * age 18 or greater. * eastern cooperative oncology group (ecog) performance status of 0-2 * satisfactory liver and kidney function. * greater than 4 weeks from prior chemotherapy or radiation therapy. exclusion criteria: * central nervous system abnormality. * uncontrolled active infection.

Keywords: aml acute myelogenous leukemia mds myelodysplastic syndrome bryostatin 1 all-trans retinoic acid atra
bromfenac to reduce inflammation in patients with pseudoexfoliation syndrome after cataract surgery

Conditions: Cataract; Pseudoexfoliation Syndrome

Summary: objective to evaluate the efficacy of bromfenac ophthalmic solution 0.09% for reducing postoperative inflammation in eyes with pseudoexfoliation syndrome (pex) undergoing cataract surgery and receiving standard postoperative eye drops (dexamethasone 0.1% plus tobramycin 0.3% ophthalmic solution). design two arms, parallel group, randomized, single center, prospective, phase iv clinical trial. participants sixty-two subjects with pex and cataract will be sequentially assigned, according to a computer-generated randomization list (1:1), to bromfenac (n = 31) or not (n = 31). intervention cataract surgery by means of phacoemulsification and implantation of posterior-chamber intraocular lens will be performed by two experienced ophthalmic surgeons. standard arm: only a standard antibiotic and steroid ophthalmic suspension will be given starting the day after the surgery for two weeks, dosed qid for the first week and bid for the second week (dexamethasone 0.1% and tobramycin 0.3% eye drops association). experimental arm: eyes will receive bromfenac bid for two weeks starting the day after surgery. standard post-operative topical antibiotic and steroid will be also given concurrently, dosed qid for the first week and bid for the second week (dexamethasone 0.1% and tobramycin 0.3% eye drops association). measurements will be carried out at baseline and after one day, 3 days, 1 week and 4 weeks from cataract extraction.


Eligibility criteria:
inclusion criteria: * cataract * pseudoexfoliation syndrome exclusion criteria: * history of ocular inflammation or trauma * previous intraocular surgery * corneal haze * retinal vascular disease * diabetic retinopathy * variation of the foveal profile at oct (macular edema, epiretinal membrane) * moderate to severe age related macular degeneration
depression, anxiety and social relationships as risk factors for dementia

Conditions: Dementia; Dementia Alzheimers; Risk Factor; Depression; Anxiety; Social Isolation; Loneliness

Summary: the main objective of the present work is to establish a firm knowledge base regarding depression and anxiety as risk factors for dementia and how social relationships impact this association. this risk factors, and efforts to reduce them are described through a follow up over three decades.

the health study in nord-trondelag (hunt) fulfils most of the key requirements of a population-representative cohort study by meeting the following elements: firm knowledge about the population denominator, knowledge about reasons for refusal (in line with previous methods in hunt), options for levels and localisation of participation (at test station, at home, at nursing homes), coverage of sociodemographic features by the comprehensive hunt4-protocol and register linkage, inclusion of institutionalized individuals and individuals with reduced capacity to consent, measurement of risk and compensatory factors across the life course by merging with previous results in hunt surveys and linkage to registries, core elements and assessment methods can be compared with other european populations studies including elderly people, and finally, the ability to include biobank results in the data analysis. the hunt data supplemented by register linkage include all established and suspected risk factors of dementia. a particular focus on primary health care is appropriate because it is in this part of the health care system that the need for extra resources due to the substantial increase in dementia prevalence is most pronounced. furthermore, preventive measures in a life-course perspective will mainly have to be implemented in the primary health care setting.

Eligibility criteria:
inclusion criteria: * living in designated area exclusion criteria: * none
development and evaluation of an evidence-based education program for people with hand dysfunction in scleroderma

Conditions: Scleroderma, Systemic

Summary: the purpose of this study is to develop an evidence-based educational program for scleroderma patients with hand dysfunction. the program includes a self-care handbook and multimedia video resources. the study aims to answer: does the intervention improve hand function in the experimental group compared to the control group? does the intervention improve self-care knowledge of hand dysfunction? does the intervention improve overall health? participants will receive an 8-week program, while the control group receives usual care. outcome measures include hand function, overall health, and self-care knowledge.

the study will adopt a repeated measures randomized controlled trial design (parallel randomized controlled trial) using convenience sampling. participants in the experimental group will receive an "evidence-based scleroderma hand dysfunction education program" provided by the researchers for eight weeks. the control group will receive standard medical care during the study period and will receive the same scleroderma hand dysfunction education program as the experimental group after the study concludes. both groups will undergo pre-intervention assessments, as well as post-intervention assessments at the fourth and eighth weeks. the primary outcome measures include evaluating the effectiveness of the education program in improving hand dysfunction severity, overall health, adherence to rehabilitation exercises, and self-care knowledge related to hand dysfunction.

Eligibility criteria:
inclusion criteria: 1. participants with systemic sclerosis who meet the 2013 american college of rheumatology (acr) / european league against rheumatism (eular) diagnostic criteria and have hand dysfunction. 2. adults aged 18 years or older. 3. participants who are conscious and able to communicate in mandarin chinese or taiwanese hokkien. 4. participants who provide informed consent to participate in the study after being briefed on its purpose. exclusion criteria: 1. participants who have participated in any other hand rehabilitation program within the past three months. 2, participants with organic brain dysfunction. 3. participants with severe visual or hearing impairments. 4. participants with serious illnesses that hinder communication or interfere with the normal learning process.

Keywords: scleroderma hand dysfunction evidence-based knowledge translation patient education
prct of ficb vs lai for hip arthroscopy

Conditions: Femoroacetabular Impingement

Summary: a prospective randomised controlled trial involving patients undergoing hip arthroscopy. participants were randomised to receiving either fascia iliaca compartment block (ficb) or local anaesthetic infiltration (lai) of the portal tracts with local anaesthetic. supplemental analgesia was also used in both groups on an on-demand basis. pain level is assessed at 1,3,6, and 24 hours post surgery. the primary outcome measure was the post-operative level of pain as assessed by numeric pain score 6 hours after surgery. secondary outcome measures were the frequency and the dose of morphine and other medications consumed at 1 and 24 hours after surgery as well as any other adverse events relating to pain or medications used for pain relief in both the groups.


Eligibility criteria:
inclusion criteria: * patients over the age of 18 years * primary elective hip arthroscopy on a native hip for combined soft tissue injuries and fai pathology * able to read, write and communicate in english exclusion criteria: * patients who did not want to be involved in the trial * unable to give informed consent * previous hip surgery * patients younger than 18 years of age * chronic opioids users * patients known to have an allergy or intolerance to local anaesthetic agents or none steroidal anti-inflammatory medications

Keywords: fascia iliaca block local anaesthetic infiltration hip arthroscopy
pioneer: intraoperative and perioperative oct study

Conditions: Retinal Detachment; Epiretinal Membrane; Macular Hole; Fuchs Endothelial Dystrophy

Summary: oct provides high-resolution information regarding the anatomic structure of the tissues of the eye in a 2-dimensional and 3-dimensional view. much of this information is not able to be recognized by a clinician. utilizing this information during surgery will allow for ophthalmic surgeons to better understand how surgical procedures impact the anatomic structure of the eye.

over the last decade, optical coherence tomography (oct) has become a critical component to the evaluation of ophthalmic disease. similar to ultrasound, oct uses light to reconstruct an image of the tissue of interest. in effect, oct has become to function as a light biopsy, allowing clinicians to visualize subtle pathologic changes in the tissue, such as macular edema or subretinal fluid. the use of oct in the clinic setting has become the standard for monitoring diseases such as macular degeneration and diabetic retinopathy. it has quickly become the most frequent ordered diagnostic test in ophthalmology. due to restraints in the size and structure of the imaging equipment, the use of oct in the operating room has been limited. more recently, modifications to oct table-top models as well as the development of hand-held oct probes have allowed for the translation of oct technology into the operating room. the high resolution anatomic information that is gained from oct imaging is a natural complement to the ophthalmic surgeon. using oct during vitreoretinal surgery has revealed subtle changes in the microarchitecture of the retina in diseases such as retinal detachment, macular hole, and optic pit, that were not previously known. using oct during lamellar corneal transplant procedures, anterior segment surgeons have been able to image proper placement of the graft that was previously unattainable with a standard surgical microscopic view. using information gained from oct, surgeons may be able to improve surgical decision making and improve clinical outcomes. for this study, subjects undergoing ophthalmic surgery, including vitreoretinal surgery and anterior segment surgery, would have oct imaging performed in the perioperative period, intraoperative period, or both to document architectural changes in the ocular tissues. this information would be prospectively collected and reviewed for associations with anatomic and functional outcomes. a microscope-mounted oct system will be used to assess feasibility and utility of imaging during ophthalmic surgical milestones.

Eligibility criteria:
inclusion criteria: * the study population includes any patient requiring ophthalmic surgery exclusion criteria: * children under the age of 18 * cognitive/mentally impaired or unable to provide consent * media opacity precluding oct scanning

Keywords: oct image-guided surgery vitreoretinal surgery corneal surgery
transvaginal versus fluoroscopy-guided trans gluteal pudendal nerve block for pudendal neuralgia

Conditions: Pudendal Neuralgia; Chronic Pelvic Pain Syndrome

Summary: chronic pain affecting the pelvic and urogenital area is a major clinical problem and can have a profound impact on quality of life and health care costs. pelvic pain arising from entrapment or neuropathy of the pudendal nerve is known as pudendal neuralgia, which results in chronic perineal pain. this pain syndrome is difficult to diagnose and patients with pudendal neuralgia may present to providers with refractory chronic pelvic pain. pudendal nerve infiltration or pudendal nerve block (pnb) serves as a diagnostic tool and treatment modality for patients with this condition. to date, there are no published randomized controlled trials comparing imaging-guided pnb to transvaginal finger-guided pnb. while one can assume that image-guided nerve blocks will provide better accuracy for injection and potentially better efficacy in pain relief as a result, no published data exists comparing the outcomes and efficacy between modalities. the purpose of this prospective, non-inferiority, randomized controlled trial is to compare the efficacy of pain relief from bilateral transvaginal finger-guided pudendal nerve block versus bilateral fluoroscopy-guided trans gluteal pudendal nerve block for patients with pudendal neuralgia.

primary objective: determine the efficacy of pain relief comparing the change in visual analog scale (vas) from baseline to 6 weeks in women randomized to transvaginal pnb (without imaging) versus trans gluteal fluoroscopy-guided pnb. upon completion of 6-week follow-up, participants will be given the option to crossover to the alternative treatment arm secondary objectives: characterize the effect of either pudendal nerve block approach using the following validated questionnaires * promis-29 (degree of pain intensity and bother across health domains) * pain catastrophizing scale (emotional and cognitive impact of pain) * short-form mcgill (qualitative pain) * patient satisfaction with medical care * baseline demographics * baseline vas * adverse events * determine the time to peak pain relief and duration of injection pain relief

Eligibility criteria:
inclusion criteria: * women \>18 years * english speaking/reading * diagnosis of pudendal neuralgia or chronic pelvic pain with pain in the distribution of the pudendal nerve for 3 months or longer * minimum pain/bother score of 4/10 * desire for pudendal nerve block exclusion criteria: * contraindication to pudendal nerve block (examples: skin or vaginal infection, bupivacaine allergy, uncorrected coagulopathy) * pregnant or intending to become pregnant during the study * pudendal nerve block from any route within the last 3 months * major pelvic surgery within the last 3 months (examples: hysterectomy, prolapse repair, midurethral sling) * neurologic disease affecting the perineum (examples: spinal cord injury, multiple sclerosis)