Kornimate/medical-research-clean huggingface dataset:
treatment of chronic medium-severe periodontitis with mesenchymal stem cells predifferentiated in osteogenic direction

Conditions: Periodontitis, Chronic

Summary: treatment of chronic medium-severe periodontitis with mesenchymal stem cells and mesenchymal stem cells predifferentiated in osteogenic direction

the bone defect will be filled with a porous membrane based on bone collagen measuring 5x5 mm or more with mesenchymal stem cells and mesenchymal stem cells predifferentiated in osteogenic direction

Eligibility criteria:
inclusion criteria: - chronic medium-severe periodontitis exclusion criteria: * pregnancy * breast-feeding * acute and chronic infectious diseases: hiv, viral hepatitis, tuberculosis * mental disorders

Keywords: periodontitis mesenchymal stem cells
work and vocational advice study - effectiveness of adding a brief vocational support intervention to usual primary care

Conditions: Musculoskeletal Pain; Mental Health Issue; Mental Health Disorder; Other Physical Health Condition; Absence

Summary: maintaining the population's fitness for work is a priority for the uk government. people with poor health often struggle at work and take sick leave. work brings financial, social and health benefits. few employees receive support to manage their health at work, known as vocational advice, so when their health affects work they visit their general practitioner (gp). the investigators have recently shown the benefits of providing vocational advice for adults consulting in primary care with musculoskeletal pain. the wave study research question is: in patients consulting in general practice who receive a fit note for time off work, does a brief vocational advice intervention lead to fewer days lost from work than usual primary care, and is it cost-effective? wave includes a feasibility phase to adapt a vocational advice intervention for a broader group of patients and test it in a small sample of patients; followed by a pragmatic, multi-centre, two-arm, parallel-group randomised (1:1) trial with internal pilot phase, mixed methods process evaluation and health economic analysis. patients will be randomised to either (i) vocational advice intervention plus usual care, or (ii) usual care alone. the vocational advice intervention is designed as a stepped care model based on the principles of case management and delivered by trained vocational support workers (vsws). the investigators will also interview patients, general practitioners (gps), vsws and employers to understand their views about the intervention and return to work. participants in the trial will be followed-up over 6 months with fortnightly text messages and postal questionnaires at 6 weeks and 6 months.


Eligibility criteria:
inclusion criteria: * adults aged 18 years and over * currently in paid employment (full or part time) * current absence from work of at least two consecutive calendar weeks but not more than six continuous months * received a fit note * access to a mobile phone that can receive and respond to sms text messages * able to read and write english * able to give full informed consent * willing to participate. exclusion criteria: * long-term work absence defined as over six continuous months * pregnancy or on maternity leave * patients presenting with signs or symptoms indicative of serious illness requiring urgent medical attention ('red' flags) * severe mental health problems (e.g. severe depression with risk of self-harm, exacerbation of schizophrenia or bipolar disorder, cognitive impairment or lack of capacity) * high vulnerability (e.g. palliative stages of illness, recent bereavement, dementia).

Keywords: work absence other health conditions return to work musculoskeletal pain mental health
comparative study of endometrial polypectomy performed with bipolar electrode versapoint and laser diode. a randomised controlled trial.

Conditions: Endometrial Polyps

Summary: hysteroscopy today is considered the gold standard for the diagnosis and treatment of endometrial polyps. in recent years we have used the bipolar energy for resection of polyps by hysteroscopy, becoming a routine clinical practice and universally accepted. resection of endometrial polyps laser energy has recently begun to be used with satisfactory results, so studies are needed to analyze these results and compare it with the usual techniques . this time in advance of medicine, it is appropriate to introduce minimally invasive procedures , allowing resection of endometrial polyps on an outpatient basis without anesthesia and acceptable to most patients. these procedures assume a lower cost and are associated with a lower surgical risk due to their realization without anesthesia . hypothesis: resection of polyps outpatient laser diode has a similar or superior to that of the bipolar electrode tolerability. the diode laser is a viable , quick , simple technique with a high percentage of resection and high degree of satisfaction of patients

main objective: to assess the tolerability of diode laser in the treatment of endometrial polyps using a visual analogue pain scale. secondary objectives: * determine if complete resection of polyps is achieved with both methods. * compare the time spent on the removal of the polyp in each of the hysteroscopic methods. * to evaluate the safety of the laser diode with respect to the bipolar electrode (vagal syndrome, uterine perforation, infection, bleeding). * assess the recurrence of polyps after 3 months of resection (via hysteroscopy). * compare the degree of patient satisfaction with the different methods. design: randomized single blind clinical trial corresponds to an experimental analytical study. the patients randomly into 2 groups will include: group a bipolar electrode treatment versapoint and group b diode laser treatment. randomization was performed using a random table with 2 groups, generated in microsoft office excel. the sample size needed to detect a difference in visual analog pain scale of a point with respect to the laser diode bipolar electrode is calculated; assuming a standard deviation of 1.75, a sample size of 49 patients in each group (98 would be needed in total), to a level of significance of 5% (0.05 α) with a power of 0.80 (beta 0.20). assuming a loss of individuals from 5 to 10%

Eligibility criteria:
inclusion criteria: * patients previously diagnosed of endometrial polyps that can be resected. the diagnosis will be made hysteroscopically. the patient must be informed about the study, and sign the informed consent. exclusion criteria: * the usual exclusion criteria for surgical techniques, pregnant patients, patiens under 18 patients who did not sign the informed consent

Keywords: endometrial polyp resection of endometrial polyps hysteroscopy bipolar electrode versapoint laser diode
patient reported function following combined first mtp and first tmt arthrodesis.

Conditions: Hallux Valgus

Summary: the goal of the study is to gather sufficient patient data to assess real world postoperative function after a first metatarsophalangeal (mtp) joint arthrodesis done in conjunction with first tarsometatarsal arthrodesis (tmt) (double fusion). many studies have demonstrated the success of a first mtp joint arthrodesis in eliminating pain and reducing the intermetatarsal angle. very little research has been published to assess the outcomes of double arthrodesis. limited research has specifically assessed patients' everyday function and gait following mtp arthrodesis and no studies are available to assess real world function following double arthrodesis. more data that includes patient reported function during activities of daily living is needed to understand the benefits and draw backs of combined first mtp/tmt joint arthrodesis used to treat and correct first ray deformity.

* retrospective clinical data will be collected on a clinical data collection form from a chart abstraction at the research site. * all radiographs will be anonymized and transferred in a secure process to a central radiologist for the study. the data will be collected in excel spreadsheet or on a radiographic data collection form. * post-operative function and satisfaction will be collected by study personnel via telephone call with the patient * de-identified data will be entered into a database for analysis.

Eligibility criteria:
inclusion criteria: 1. patients with surgeon identified indications for double joint arthrodesis 2. previous double joint arthrodesis procedure (lapiplasty® procedure) between 2017-2021 3. procedure completed at least 12 months from the onset of the study 4. early weight-bearing protocol (\< 3 weeks) 5. patients between 18 and 80 years of age, inclusive at the time of the procedure 6. clinical and radiographic follow up available at least 6 months post double joint arthrodesis procedure 7. willing to answer the post-operative functional and satisfaction questionnaire via phone call exclusion criteria: 1. diabetes with neuropathy 2. presence of previous infection of operative foot 3. documented neuropathy of any cause 4. concomitant hindfoot or ankle procedures except tendon procedures or gastrocnemius recession

Keywords: bunion
effect of a therapeutic exercise and an education program on sexual function and experience in people with endometriosis

Conditions: Endometriosis; Sexual Function; Sex Behavior

Summary: this is a randomized clinical trial that will be carried out in people with endometriosis divided into two groups: the experimental group (eg) that will receive therapeutic exercise combine with sexual education, and the control group (cg) who will receive the therapeutic exercise program. the participants will be evaluated at three moments: before starting the study (t1), after the 8-week treatment program (t2) and after 4 weeks of follow-up in which they will be encouraged to continue with the treatment (t3). objective and subjective data of the participants will be evaluated. t1 will be assessed with a sociodemographic questionnaire and the fsfi and msscq surveys. t2 and t3 will assess blood pressure, heart rate, variability of the autonomic system, the ability to dissociate the lumbopelvic movement from the thoracolumbar, measurement of the muscles of the transverse, internal and external obliques, the distance between the rectus abdominis and the pelvic floor, subjective perception of effort during exercise and subjective perception of orgasmic intensity.


Eligibility criteria:
inclusion criteria: * people of legal age (over 18 years old) * not older than 50 years old * currently residing in spain * spanish speakers * with a medical diagnosis of endometriosis * without any other associated gynecological pathology exclusion criteria: * minors * people over 50 years old * those with cognitive limitations that prevent them from completing the different questionnaires used * people who are involved in litigation processes * people with gynecological pathologies other than endometriosis

Keywords: endometriosis sexual function sexual experience
a long-term study of mp-214 in patients with chronic phase or elderly schizophrenia

Conditions: Schizophrenia

Summary: the objective of this study is to evaluate the long-term safety, tolerability, and efficacy of mp-214 in patients with chronic phase or elderly schizophrenia.


Eligibility criteria:
inclusion criteria: * written informed consent obtained from the patient before the initiation of any study-specific procedures * patients diagnosed with schizophrenia according to the diagnostic criteria of the diagnostic and statistical manual of mental disorders, fourth edition, text revision (dsm-iv-tr) criteria for schizophrenia * patients who meet at least one of the following: * current diagnosis of schizophrenia of chronic phase * between 65 and 74 years of age * patients with normal physical examination, laboratory, vital signs, and/or electrocardiogram (ecg) exclusion criteria: * patients with a dsm-iv-tr diagnosis of schizoaffective disorder, schizophreniform disorder, other psychotic disorders other than schizophrenia, or bipolar i or ii disorder the information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Keywords: schizophrenia antipsychotic agents mental disorder psychotropic drugs dopamine agents risperidone central nervous system agents
n-acetylcysteine and nmda antagonist interactions

Conditions: Cognitive Dysfunction

Summary: this study tests the hypothesis that extrasynaptic mechanisms are critically linked with cognitive effects of nmda antagonism as evidenced by event-related potentials (erps) in healthy humans.


Eligibility criteria:
inclusion criteria: * ages of 21-45 years from all ethnic backgrounds. * male or female. * written informed consent. exclusion criteria * dsm-iv diagnosis for a psychotic, depressive or anxiety disorder. * a history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic abnormality, seizure disorder. unstable medical condition based on ekg, vital signs, physical examination and laboratory work-up (cbc with differential, sma-7, lfts, tfts, ua, utox, urine pregnancy test) . * history of severe allergies or multiple adverse drug reactions. * any medication that in the opinion of the pi could interfere with either the safety of the study and/or the outcome measures. * any other conditions which in the opinion of the investigator would preclude participation in the study. * history of major psychiatric disorder in first degree relatives. * current substance abuse/dependency determined by urine toxicology. * current treatment with medications with psychotropic effects. * treatment with benzodiazepines within one week prior to testing. * current pregnancy, unsatisfactory birth control method report for females. * education \< 10th grade. * iq \< 70, mr as determined by wechsler abbreviated scale of intelligence. * non-english speaking.

Keywords: nmda glutamate n-acetylcysteine p3
supplementing intracytoplasmic sperm injection handling medium with latrunculin b ( icsi-lb)

Conditions: Infertility

Summary: vienna consensus has identified 10% damage rate after icsi as a competency value. despite the highest quality embryologists doing icsi, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. latrunculin b serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. using latrunculin b during icsi could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,


Eligibility criteria:
inclusion criteria: * all icsi cycles exclusion criteria: -
prime - prostate imaging for margin evaluation

Conditions: Prostatic Neoplasms

Summary: this study will evaluate the feasibility of using intra-operative cerenkov luminescence imaging (cli) of prostatectomy specimens to determine tumour margin status. the samples will be imaged using the lightpathtm imaging system which consists of a light-tight box containing an ultra-sensitive lens and radiation-shielded camera. this study will measure the correlation between margin status of the wle specimen and the metastatic status of dissected lymph nodes as determined by the lightpathtm imaging system and by histopathology. this is a pilot study to assess feasibility before proceeding to a pivotal study to evaluate the benefits of the lightpathtm system in clinical practice.

this study is a prospective, single-centre feasibility study to evaluate the use of intra-operative cerenkov luminescence imaging (cli) of prostatectomy specimens to determine margin status. subjects will receive an intravenous injection of 370 mega becquerel (mbq) of 18f-choline prior to routine, elective radical prostatectomy. the surgery will be performed according to standard-of-care. the resected prostatectomy specimens will be imaged using the lightpathtm imaging system, consisting of a light-tight box containing an ultra-sensitive lens and electron multiplying charged-coupled device (emccd) camera. this study will measure the agreement between margin status of the prostatectomy specimen as determined by cli and by histopathology (reference method). this study will assess feasibility before proceeding to a pivotal study to evaluate the benefits of the lightpathtm imaging system in clinical practice.

Eligibility criteria:
inclusion criteria: * men ≥18 years of age diagnosed with high risk prostate cancer, defined as clinical stage ≥t2c, or psa\>20 ng/ml, or gleason score 8-10. * patients undergoing radical prostatectomy exclusion criteria: * known hypersensitivity to 18f-choline * patients currently taking colchicine * prior therapy for prostate cancer (e.g. focal therapy)

Keywords: prostatectomy prostate cancer cerenkov luminescence imaging
effect of vr and accommdation relax on controlling myopia in children

Conditions: Myopia; Accommodation Spasm; Children

Summary: this study evaluates the effect of virtual reality and accommodation relax technique on controlling onset and development of myopia in school-aged children. half of the children will receive head-mounted video display which shows video with virtual reality and accommodation relax technique in combination, while the other half will receive no intervention.


Eligibility criteria:
inclusion criteria: * best corrected visual acuity \>=20/20 for each eye; * astigmastism less than 1.5 d; * anisometropia less than 1.0d; * no other ocular or systematic diseases; exclusion criteria: * can not endure virtual reality video; * can not cooperate with ocular examinations; * receiving other interventions for controlling myopia;
comparison of awbat™-d and mepilex® ag for treatment of donor sites in burn surgery

Conditions: Burn Surgery

Summary: the purpose of this study is to examine awbat™-d compared to mepilex® ag for the treatment of donor sites in burn surgery.


Eligibility criteria:
inclusion criteria: * burn wounds requiring skin grafting * matched donor sites available * 1-30% tbsa exclusion criteria: * severe inhalation injury * pregnancy * co-morbidity which may compromise healing * known allergy to pork or pork products

Keywords: burn donor site treatment of burns treatment of donor sites
bronchiolitis clearance airways with seaserum

Conditions: Bronchiolitis Acute

Summary: the objective of this study is to show that the use of electrodialyzed seawater reduces the duration (in days) of symptoms in acute infant bronchiolitis compared with the use of saline solution in infants aged 1 month to less than one year. b-class study is a multicenter, prospective, controlled, randomized, double label blind.

this is a multicenter, prospective, controlled, randomized in 2 parrallel arms, double blind study. the infants will be included after written informed consent will be obtained from the patients' parents or legally authorized representatives. patients will be randomized either in the experimental group (electrodialyzed seawater) or in the control group (saline solution). patients' parents will be call by phone at day 1, day 3, day 6, day 10 and day 21 after baseline.

Eligibility criteria:
inclusion criteria: * infants aged more than 1 month and less than 1 year * first episode of acute bronchiolitis * emergency consultation * existence of nasal obstruction * onset of symptoms \&lt; 48 hours before emergency consultation * outpatient care after emergency consultation * mild to moderate bronchiolitis according to the \&#34;haute autorité de santé 2019\&#34; criteria: respiratory rate over 1 minute \&gt;30/minutes and \&lt;60/minute ; heart rate \&gt;80/minutes and \&lt;180/minutes; absence of respiratory pauses; absence of superficial breathing; absence of signs of intense respiratory struggle: involvement of the lower intercostal accessory muscles, sternocleidomastoid muscles, thoracoabdominal swinging, or flapping of the wings of the nose; feeding \&gt;50% of the usual quantity over 3 consecutive doses; spo2 \&gt; 92% during sleep ; \&gt;94% when awake; \&gt;2 months corrected age * parental consent * affiliate to a social security system exclusion criteria: * hospitalization (excluding short stay unit) after emergency consultation * oxygen therapy * history of prematurity (birth \&lt;36 weeks of amenorrhea) * history of invasive ventilation in the neonatal period * history of chronic pulmonary or cardiac pathology * history of immune deficiency * history of polyhandicap or neuromuscular pathology * history of malformative ear nose and throat pathology affecting the upper airways * impossibility of ensuring the follow-up made necessary by participation in this study

Keywords: infant nasopharyngeal decongestion bronchiolitis
efficacy of tacrolimus in adults with facial non-segmental vitiligo - vitac

Conditions: Vitiligo

Summary: multicentric french parallel double-blind randomized versus placebo study

multicentric french parallel double-blind randomized versus placebo study, with duration of treatment of 6 months, and a post-treatment follow-up period of 6 months

Eligibility criteria:
inclusion criteria: 1. subject male or female with age over 18 years old 2. diagnosis of non-segmental (symmetrical) vitiligo 3. presence of at least one vitiligo target-plaque on the face, with: area greater than 3cm² local vitiligo area severity index (vasi) score ≥ 50% stable (no change in pigmentation or size over the last 3 months) recent onset (less than 2 years duration) 4. subject affiliated to the french social security system exclusion criteria: 1. progressive vitiligo over the last 3 months 2. spontaneous ongoing repigmentation (documented in the last 3 months) 3. previous topical tacrolimus treatment in the last 3 months 4. previous topical or systemic treatment in the last month: topical or oral corticosteroid topical vitamin d phototherapy or laser other topical treatment specific to vitiligo other immunosuppressant or immunomodulator 5. underlying dermatological disease (i.e.: history of atopic dermatitis, eczema, psoriasis), which, according to the investigator, could interfere with the study assessments 6. known sensitivity to study drug or macrolides 7. past history of skin cancer or lymphoma 8. congenital or acquired immunodeficiency 9. pregnant or breastfeeding women 10. women without contraception 11. absence of signed informed consent

Keywords: vitiligo tacrolimus face