Kornimate/medical-research-clean huggingface dataset:
the prevalence of lower urinary tract symptoms in individuals with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: chronic obstructive pulmonary disease (copd) is defined as a chronic lung disease characterised by progressive airflow limitation and chronic respiratory symptoms due to structural changes in the airways. dyspnoea (shortness of breath), chronic cough and increased sputum production are the most common symptoms in individuals with copd. respiratory diseases are considered a risk factor for lower urinary tract symptoms due to cough and shortness of breath. severe coughing and shortness of breath increase intra-abdominal pressure and stress on the bladder. this can lead to leakage if the pelvic floor muscles are weak. in addition, regular coughing can further weaken the ligaments in the pelvic floor, causing symptoms. lower urinary tract symptoms is a general term covering various functional disorders of the bladder, pelvic floor or specific pathologies. the international continence society classifies lower urinary tract symptoms in three main groups: storage (increased/decreased urination, urinary incontinence, nocturia, overactive bladder), emptying (delayed urination, painful urination, intermittent urination) and post-emptying (feeling of not being able to empty the bladder completely, repeated urge to urinate, urinary tract infections). when the current literature was examined, it was observed that there are studies on the presence of urinary incontinence in patients with chronic respiratory disease, but there are limited studies investigating the presence and effects of lower urinary system symptoms in individuals with copd in general, and investigating the level of pelvic floor health knowledge. in this context, we think that our study is unique and may contribute to future rehabilitation studies in this field.


Eligibility criteria:
inclusion criteria: * being diagnosed with copd (according to gold criteria) * being clinically stable * volunteering to participate in the study exclusion criteria: * having perception and cognitive problems * having a diagnosis of unstable copd

Keywords: copd incontinance pelvic floor muscle
effect of applying cuff air leak pressure as intraoperative cuff pressure on postoperative complications

Conditions: Intubation Complication

Summary: the purpose of the study is to achieve effective ventilation with critical intracuff pressure (pcr) and determine if application of pcr reduces the risks associated with over-insufflation of endotracheal cuff including postoperative sore throat, cough,nausea, vomiting, aspiration, and pneumonia.


Eligibility criteria:
inclusion criteria: * elective surgery under general anesthesia requiring endotracheal tube with mechanical ventilation and expected anesthesia duration of at least 2 hours. * no contra-indication for intra-operative volume controlled mechanical ventilation * flat supine surgeries without expected positional adjustments * american society of anesthesiologists (asa) physical status i-iii exclusion criteria: * use of nitrous oxide * bmi \> 40 * ventilation through nasal intubation or tracheostomy * preexisting sore throat, coughing, nausea/vomiting * recent history of upper respiratory infection * pregnancy * expected to be kept intubated after surgery completion

Keywords: anesthesia endotracheal tube cuff pressure
additional effects of dry needling with pnf on spasticity and functional performance in stroke

Conditions: Spasticity; Dry Needling; Functional Performance

Summary: stroke is a prevalent cause of long-term disability, with a rising global incidence. stroke patients commonly experience impaired balance and trunk control, which limits their daily activities and quality of life. spasticity is the result of upper motor neuron lesion in which the reflex arc is spared, however there is a lesion to the descending pathways of the spinal cord, which leads to the hyper excitability of the alpha motor neurons. spasticity is a form of velocity dependent hypertonia. when dry needle is applied it induces relaxation in the muscle by increasing the distance between the z lines in the sarcomere and reduces the overlapping of contractile proteins, which ultimately leads to relaxation in the muscle. dry needling also reduces the firing of the afferent pathways from the local muscle to the spinal cord reducing the excitability of the alpha motor neurons this leads to reduce spasticity. a randomized control trial will be conducted in multidisciplinary lab of fucp, department of physical medicine and rehabilitation of fauji foundation hospital on the sample of 30 participants. the subjects will be randomized into two groups by sealed opaque envelope method. a treatment over the course of 6 weeks will be provided. interventional group will be receiving dry needling in addition to proprioceptive neuromuscular facilitation while the control group will receive sham needling in addition to proprioceptive neuromuscular facilitation. exercise training would be done for a total of 6 weeks, with needling twice a week, the session will last 30- 50 minutes. using spss version 21 would do analysis. ethical approval will be obtained from erc of fush. informed written consent will be obtained from all participants.

* to determine the effects of balance training with and without gaze stability exercises on mobility in older adults with mild cognitive impairment. to determine the additional effects of dry needling with proprioceptive neuromuscular facilitation in comparison to sham needling with proprioceptive neuromuscular facilitation on spasticity in stroke. * to determine the effects of dry needling with proprioceptive neuromuscular facilitation techniques in comparison to sham needling with proprioceptive neuromuscular facilitation on functional performance in stroke

Eligibility criteria:
inclusion criteria: * 18 years to 65 years of age. * males and females * post stroke spasticity * ischemic stroke exclusion criteria: * non-compliant diabetic patients * active hypertensive patients * immuno compromised patients * patients with underlying infections * patients with autoimmune diseases * patients that have any contagious conditions

Keywords: spasticity stroke dry needling functional performance emg fugl meyer modified ashworth scale
a study to evaluate nutropin aq for the treatment of growth restriction in children with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: this is a phase ii, multicenter, randomized, controlled, open-label trial of the safety and efficacy of nutropin aq administered subcutaneously (sc) daily in prepubertal children with cf and growth restriction.


Eligibility criteria:
inclusion criteria: * ability of parent or legal guardian to provide written informed consent and, if applicable, pediatric assent and compliance with study assessments for the full duration of the study * diagnosis of cf by sweat or genetic testing * between the ages of 5 and 12 years for girls and 5 and 13 years for boys * ability to perform pulmonary function tests in a reproducible manner, per american thoracic society guidelines for spirometry * height \<= 10th percentile for age and sex * prepubertal, tanner stage 1 * bone age of the non-dominant hand and wrist obtained no more than 6 months prior to study entry (bone age must be \<= 10 years for girls and \<= 11 years for boys as read using the method of greulich and pyle) * adequate caloric intake (following the cff guidelines is encouraged; caloric intake must be documented at screening using a 24-hour food diary) * normal thyroid function exclusion criteria: * prior or current rhgh use * history of short stature due to ghd * history within the 12 months prior to screening of glucose intolerance (impaired glucose tolerance) or cf-related diabetes (cfrd) as defined by at least one of the following: fasting serum glucose of \>= 126 mg/dl on two or more occasions; fasting serum glucose of \>= 126 mg/dl plus any casual (previously called random) glucose level \>= 200 mg/dl; casual (previously called random) glucose of \>= 200 mg/dl on two or more occasions; fasting serum glucose of \<= 126 mg/dl but 2-hour post oral glucose load of 140-199 mg/dl (impaired glucose tolerance) on two or more occasions; if a subject meets the criteria for impaired glucose tolerance or cfrd in the screening glucose tolerance test, even if there is no history of impaired glucose tolerance, the subject will not be eligible for the study. * infection with burkholderia cepacia * qualitative change in antibiotic treatment (e.g., for exacerbation of lung infection) within 14 days of study entry * hospitalization or treatment with systemic corticosteroids during the 30 days prior to study entry * inability to adhere to previously documented adequate nutrition * active neoplasia * participation in any other investigational study (including investigational drug studies) within 30 days of enrollment or during the study if in the treatment arm, except for participation in observational and questionnaire studies (untreated) * subjects who require, as part of the their medical care, scheduled elective hospitalizations for iv antibiotic therapy

Keywords: growth restriction in children with cystic fibrosis
randomized study in severe aplastic anemia patients receiving atg, cyclosporin a, with or without g-csf (saa-g-csf)

Conditions: Aplastic Anaemia

Summary: the purpose of this study is to examine the effect of g-csf on disease free survival and overall survival in aplastic anaemia patients who also receive atg and cyclosporin a.

open label, randomized, controlled study of g-csf, atg and cyclosporin a versus atg and cyclosporin a. subjects will be evaluated for hematologic response through day 240. subjects who do not demonstrate a partial or complete remission by day 120 will be randomized to receive either a second course of atg or continue their current regimen. subjects who do demonstrate a partial or complete remission will continue their current regimen through day 240 or maintenance of a complete remission for 30 days. the last day of study treatment will be day 240.

Eligibility criteria:
inclusion criteria: * severe or very severe aplastic anemia * less than 6 months from diagnosis of severe aplastic anemia by bone marrow biopsy * ethical - before randomization is done the subject or legally acceptable representative must give written informed consent for participation in the study exclusion criteria: * eligibility for an hla-matched sibling donor transplant * prior therapy with atg * cyclosporin a \<4 weeks before enrollment * treatment with g-csf \<2 weeks before enrollment * other growth factors \<4 weeks before enrollment * diagnosis of fanconi anemia, dyskeratosis congenita or congenital bone marrow failure syndrome * evidence of myelodysplastic disease * diagnosis or previous history of carcinoma (except local cervical, basal cell, squamous cells, or melanoma) * subjects who have infection, hepatic, renal cardiac, metabolic or other concurrent diseases of such severity that death is imminent * subject is pregnant (e.g. positive hcg test) or is breast feeding
spinal morphine provides an effective pain control in patients undergoing transurethral resection of prostate gland

Conditions: Spinal Anesthesia; Transurethral Resection of Prostate; Analgesia

Summary: pain after transurethral resection of prostate is considered mild to moderate severity from detrusor muscle spasm and traction from urinary catheter. numerous pain relieve methods have been studied including spinal opioids, spinal anesthesia with local anesthetic and dexmedetomidine, periprostatic nerve blockade with bupivacaine and mixing of prilocaine with distilled water irrigation while undergoing a procedure. most of patients having this procedure are in elderly period, thus many anesthetists avoided spinal morphine which may cause respiratory depressant effect postoperatively. although previous studies showed effectiveness of spinal morphine 25-200 mcg, some patients suffered from neuraxial opioid side effects. the aim of this study is to demonstrate efficacy of local anesthetic with intrathecal morphine 50 mcg providing pain relieve after transurethral resection of prostate compare to spinal anesthesia with sole local anesthetic.


Eligibility criteria:
inclusion criteria: * age \> or = 18 years old * undergoing transurethral resection of prostate gland exclusion criteria: * contraindication for spinal anesthesia for any reasons eg. infection, bleeding disorder * refuse spinal anesthesia * allergic to study drugs * history of cerebrovascular disease or stroke

Keywords: spinal anesthesia intrathecal morphine transurethral resection of prostate postoperative pain
wearable device intervention to improve sun behaviors in melanoma survivors

Conditions: Melanoma (Skin)

Summary: over 5 million new cases of skin cancer are diagnosed in the united states each year, more than all other cancers combined. most of these cases are caused by excess exposure to ultraviolet radiation from the sun and artificial sources such as indoor tanning. melanoma, approximately 87,000 of the annual skin cancer cases and one of the more deadly skin cancers, is on the rise. previous research on these individuals suggests that while some change how much time they spend in the sun and adopt ways to protect themselves when in the sun, many do not. in our previous study, we found that 20% of melanoma survivors reported a sunburn in the past year and 10% intentionally went outside for a tan, both strong indicators of inappropriate sun exposure. melanoma survivors are at high risk of second melanomas, making it critical that they spend less time in the sun or take actions to protect themselves when they are in the sun. no studies to date have investigated technology-based strategies in melanoma survivors to improve sun exposure and protection behaviors. this project will test whether a wearable device that tracks sun exposure and provides alerts regarding sun exposure and protection behaviors will increase sun protection behaviors in melanoma survivors. the use of wearable technology devices (e.g., fitbit) has grown quickly over the last decade and studies using these devices to promote physical activity and weight loss have been promising. we will test the technology device versus a similar control device in 368 melanoma survivors and compare sun protection behaviors between the two groups. this project has the potential to identify a strategy that could significantly lower the number of melanoma survivors who go on to have a second melanoma diagnosis. importantly, this easy to use technology could also be utilized by survivors' family members, who are also at higher risk for melanoma, and the general population as a means to reduce risk of all forms of skin cancer.


Eligibility criteria:
inclusion criteria: * 18-75 years old * diagnosed with cutaneous invasive melanoma within healthpartners system * able to read/write in english * own a smartphone * able to provide voluntary informed consent exclusion criteria: * patients who have opted out of their records being used for research purposes * inability to provide informed written consent * pregnancy

Keywords: sun protection sunburn
comparison of local anesthetic infiltration and different fascial plane blocks in inguinal hernia repair

Conditions: Postoperative Pain; Inguinal Hernia; Local Infiltration; Quality of Recovery; Quadratus Lumborum Block; Transversus Abdominis Plane Block

Summary: in this study, quadratus lumborum block (qlb), transversus abdominis plane (tap) block, and local anesthetic infiltration will be performed preoperatively in patients who will undergo unilateral inguinal herniorrhaphy operation under general anesthesia. quality of recovery (qor-15) score, postoperative acute and chronic pain levels will be evaluated.

inguinal hernia repair, one of the most common operations, causes moderate to severe postoperative pain. the postoperative pain delays patients' recovery and return to daily life, increases the rate of readmission to the hospital, and can lead to persistent postoperative pain.procedure-specific postoperative pain management (prospect) recommendations for optimal pain management have been recently updated. accordingly, in addition to preoperative or intraoperative paracetamol and nonsteroidal anti-inflammatory analgesics, local anesthetic infiltration and/or regional analgesia techniques (ilio-inguinal nerve blocks or tap block) with rescue opioids are recommended. also, it has been reported that further research is needed on new regional techniques (other fascial plane blocks etc).it has been shown that qlb potentially results in extensive sensory blockade (t7-12), and in cadaver studies, the iliohypogastric and ilioinguinal nerves are constantly involved. in addition, there are studies suggesting that it provides much longer analgesia than tap block. there are few studies on its efficacy in inguinal hernia repair that are in pediatric cases or performed in addition to central blocks. it is hypothesized that qlb may provide better and longer analgesia, may increase the quality of recovery and reduce the development of resistant chronic pain, compared to other regional methods such as local infiltration or tap block, that proven effectiveness.

Eligibility criteria:
inclusion criteria: * patients who will undergo elective unilateral inguinal herniorrhaphy under general anesthesia * american society of anesthesiology (asa) physical classification i-iii exclusion criteria: * patients who will undergo laparoscopic surgery * previous inguinal hernia repair surgery * a history of opioid use or pain management * coagulopathy or anticoagulant use * patients who have difficulty communicating or who are not cooperative
quantifying fatigue in cancer patients using smart bracelet devices

Conditions: Cancer-Related Condition

Summary: this project expects to enroll 60 cancer patients, 60 healthy people and their subjective-objective measurements on fatigue, stress, and total steps will be validated so that the information can be used in further care and improvement of life of quality of the patients.


Eligibility criteria:
inclusion criteria: * age ≧ 20 years old; * one group had a cancer diagnosis, one group no cancer diagnosis; * can continuous wearing bracelet for 5 days or more exclusion criteria: * unclear and unable to answer the questionnaire

Keywords: cancer-related fatigue smart bracelet device
sugarsquare. focus on the adolescent: digital treatment of type 1 diabetes through the internet

Conditions: Diabetes Mellitus

Summary: background the treatment of diabetes is multidisciplinary. alignment of care of the various professional disciplines is, however, not always optimal. this can lead to confusion about treatment interventions and behavioral advices. in adolescence, good fine-tuned care is of extreme importance because of the difficulties in regulation of the disease in this phase of life (snoek, 2004). these difficulties are due to biological changes but also to socio-psychological developmental changes. the adolescents' psychological development demands more autonomy and responsibility for the diabetes (care) by the adolescent. the social development can conflict with the treatment regime, because of the adolescents' social needs (ada, 2001; houdijk, 1998; snoek, 2004). in this study the investigators assess whether an interactive website, on which adolescents with diabetes and their treatment team can communicate, leads to better alignment of care and better control over the disease. intervention the diabetes has great impact on the adolescents' everyday life. finding a balance between more autonomy, participating in social life with (healthy) peers and control of the disease is difficult and seems to act as a thread during this phase in life. this can lead to questions and uncertainty at any given moment. the interactive website provides the adolescent access to information and to his or her individual treatment plan and advices fitted to his or her condition and life. the adolescent can pose questions at any given moment through the online forum and their personal treatment page. since the treatment team answers the question within a day, fit between diabetes care and adolescents' everyday life is optimized. research question does an online interactive treatment environment, on which adolescents with diabetes can communicate with their treatment team, lead to better fit of care and to better disease control?


Eligibility criteria:
inclusion criteria: * adolescents aged 12 and older; * diagnosed with diabetes mellitus; * receiving regular outpatient hospital-delivered diabetes care provided by the children's diabetes center nijmegen (cdcn) exclusion criteria: * adolescents who were unable to read questionnaires because of language, or cognitive problems were excluded

Keywords: diabetes mellitus adolescent online intervention psychosocial quality of life
work place adjusted intelligent physical exercise reducing musculoskeletal pain in shoulder and neck (vims) - shoulder function

Conditions: Rehabilitation; Neck Pain; Shoulder Pain; Scapular Dyskinesis; Muscle Activation

Summary: basic strength training for the neck/shoulder muscles can decrease intensity of neck/shoulder pain, but it is uncertain whether training should focus directly on the upper trapezius - which is most often tender - or on the lower compartments and serratus anterior. we hypothesize that strengthening exercise for the lower and middle trapezius as well as the serratus anterior will decrease intensity of neck/shoulder pain among office workers


Eligibility criteria:
inclusion criteria: * employees * more than 30 days with pain previous year * pain intensity of at least 3 on a scale of 0-10 exclusion criteria: * trauma * life threatening disease * pregnanacy
goals of care: a nursing home trial of decision support for advanced dementia

Conditions: Dementia

Summary: this cluster randomized controlled trial is to examine whether decision support for goals of care can improve quality of communication and decision-making and improve the quality of palliative care for nursing home residents with advanced dementia.


Eligibility criteria:
inclusion criteria: * surrogate for nursing home resident with advanced dementia, paired with resident with advanced dementia exclusion criteria: * non-related legal surrogate without personal knowledge of resident

Keywords: dementia, decision making