Kornimate/medical-research-clean huggingface dataset:
quetiapine in prevention of delirium

Conditions: Delirium

Summary: the aim is to study the effectiveness of quetiapine in preventing delirium in the elderly patients with multiple risks for delirium.


Eligibility criteria:
inclusion criteria: * patients with anemia * sedated patients * hypotensive patients * immobilized patients * patients with visual or auditory impairment exclusion criteria: * patients or guardians refuse to participate * patients diagnosed with delirium * contraindication for delirium
multiple dose escalation trial of pf-04308515 in healthy volunteers

Conditions: Healthy

Summary: the purpose of this study is to determine the safety, tolerability, pharmacokinetics and pharmacodynamics (how the drug effects certain target sites of activity in the body) of escalating doses of oral pf-04308515 in healthy volunteers for 14 days as well as one oral dose of a tablet formulation administered for 1 day.


Eligibility criteria:
inclusion criteria: * healthy males between 18 and 55 years, inclusive * healthy females between 18 and 44 years, inclusive * females are required to be surgically sterile exclusion criteria: * evidence or history of clinically significant disease * post-menopausal women * history of intolerance or significant adverse effects with glucocorticoid therapy

Keywords: safety tolerability pharmacokinetics/pharmacodynamics rheumatoid arthritis healthy volunteers
pharmacokinetics and safety of alisporivir in subjects with end stage renal disease on hemodialysis compared to healthy subjects

Conditions: Kidney Failure, Chronic

Summary: the primary objective of the study was to compare the single dose pharmacokinetics of alisporivir in subjects with end stage renal disease (esrd) on hemodialysis to those of matched healthy subjects. the secondary objective was to evaluate the safety and tolerability of a single dose of alisporivir when administered to subjects with esrd.


Eligibility criteria:
inclusion criteria: * provides written informed consent before any assessment is performed * matched healthy participants are in good health as determined by past medical history, physical examination, vital signs, laboratory tests, and other assessments * esrd participants are on a protocol-defined stable hemodialysis regimen and have no evidence of hepatic decompensation, with vital signs and other tests within protocol-specified limits * weighs at least 50 kg * is able to communicate well with the investigator, to understand and comply with the requirements of the study. exclusion criteria: * has history or current use of over-the-counter medications, dietary supplements, or drugs (including nicotine and alcohol) outside protocol-specified parameters * has signs, symptoms or history of any condition that, per protocol or in the opinion of the investigator, might compromise: 1. the safety or well-being of the participant or study staff; 2. the safety or well-being of the participant's offspring (such as through pregnancy or breast-feeding); 3. the analysis of results
the effect of low level laser therapy (lllt) in myofacial pain syndrome

Conditions: Myofacial Pain Syndrome

Summary: temporomandibular disorders (tmds) are the major cause of non-dental pain in orofacial area. laser therapy can be considered as one of the most recent treatment approaches in the field of physiotherapy. the special features of laser light such as coherence, monochromaticity, and collimation can result in the ability of laser light to modify cellular metabolism, increase tissue repair and reduce edema and inflammation. several studies demonstrated successful results regarding the use of low level lasers in releasing pain of musculoskeletal conditions, but there are also contradictory reports in this field, and the clinical effectiveness of this treatment modality has been debated in some review articles. a few studies evaluated the efficacy of low level laser therapy in the treatment of temporomandibular disorders and the associated myofacial pain. there are remarkable variations in the methodology of these researches and some reported insufficient data regarding the physical properties of the laser used. the aim of this study is to evaluate the effectiveness of low level laser therapy in improving the sign and symptoms of patients suffering from myofacial pain syndrome.

this study will be implemented on 20 patients referring to department of prosthetic dentistry of mashhad dental school. the patients are selected according to the rdc/tmd criteria to include those having temporomandibular disorders with muscular origin. the patients will be randomly assigned to two groups: group 1 (treatment group) will receive low level laser therapy. the laser light will be applied with 890 nm diode laser (mustang 2000+, russia) with frequency of 1500 hz, and dose of 2 j/cm2 per point in the painful muscles. in group 2 (placebo) the low power laser will be applied with a minimal dose that is very lower than the threshold necessary for therapeutic effects. laser therapy for both the treatment and placebo groups will be applied on all painful muscles three times a week for four weeks. patients will be evaluated at the start of the treatment, after the 6th and 12th sessions of laser therapy and also one month after the end of the treatment. at each evaluation, the maximum mouth opening with or without pain and masticatory muscle tenderness will be measured. pain will be measured through the visual analogue scale (vas). the range of lateral and protrusive mandibular movements, and the difficulty in chewing food will also be evaluated.

Eligibility criteria:
inclusion criteria: * the patients are selected according to the rdc/tmd criteria to include those having temporomandibular disorders with muscular origin. exclusion criteria: 1. patients with disk displacement (with or without reduction) 2. patients with temporomandibular joint arthralgia or osteoarthritis 3. patients with systemic disease affecting temporomandibular joint 4. patients receiving analgesic or antidepressant drugs

Keywords: tmd myofacial pain syndrome low level laser therapy lllt
a rct of an aebt website for adults with skin picking

Conditions: Excoriation (Skin-Picking) Disorder

Summary: the goal of this clinical trial is to test an online intervention for adults with excoriation disorder (skin picking). the main questions it aims to answer are: 1. is the online intervention effective, compared to a waitlist control condition? 2. is the online intervention acceptable to use? participants will be randomized into either the online intervention or waitlist control condition: 1. participants in the intervention condition will be asked to complete an 8 module acceptance-enhanced behavioral training (aebt) program for skin picking and 4 surveys over 3 months. 2. participants in the waitlist condition will be asked to complete 4 surveys over 3 months, and will receive access to the intervention once the study is complete.

excoriation disorder, also known as skin picking, is a chronic repetitive condition that impacts an individual's daily functioning and causes clinically significant distress. excoriation is estimated to impact between 2-5% of the general population, although some studies have found up to 14% prevalence rates in undergraduate samples. acceptance-enhanced behavioral training (aebt), has shown promising results for targeting skin picking symptoms. however, a recent study demonstrated that mental health providers have limited knowledge of skin picking and how to treat it effectively, creating a dearth of available treatment opportunities . this study aims to address the gap in accessible evidence-based excoriation treatment by examining the efficacy and feasibility of a self-guided, online program based in aebt. participants will be recruited from across the united states from august to november 2023, and will be randomized into either the online intervention group or a waitlist control condition. all participants will complete online self-report assessments at baseline, mid-, post-intervention, and 1 month follow-up, and waitlist participants will be provided access to the program once the study is complete. for the primary aim evaluating efficacy, the investigators predict that both primary (skin picking severity) and secondary outcomes (psychological flexibility, well-being, and distress) will be significantly improved in the active treatment condition compared to a waitlist control group. for the secondary aim evaluating feasibility, the investigators predict that participants will report acceptable feasibility as measured through treatment adherence, reports of usability, and program feedback.

Eligibility criteria:
inclusion criteria: * currently meet criteria for dsm-5 excoriation disorder * at least 18 years old at intake * fluent in english * reside in the united states exclusion criteria: * currently receiving alternative psychotherapy for skin picking * modifying or starting psychotropic medication 30 days prior to starting the study * currently living outside of the united states * under the age of 18 * did not meet dsm-5 criteria for excoriation at the time of intake session

Keywords: acceptance and commitment therapy (act) acceptance-enhanced behavioral training (aebt)
atrial fibrillation screening with a smartphone device and iecg application

Conditions: Atrial Fibrillation

Summary: question: can atrial fibrillation (af) cases in patients ≥ 65 years be easily detected in a primary healthcare environment using a smartphone device and iecg application as an opportunistic screening tool? objectives: detection of af through cardiac rhythm abnormalities in patients ≥65 years old in an opportunistic screening program using a smartphone device/application 1. define the predictable value of the smartphone device with electrocardiogram (ecg) confirmation to detect af in patients 65 years and older 2. correlate screened patients cardiovascular risk profile and those that register cardiac rhythm irregularities for a better description of the general characteristics of colombian population


Eligibility criteria:
inclusion criteria: * females and males patients ≥65 years old attending primary care counselling * written informed consent exclusion criteria: * patients with confirmed diagnosis of af * patients who do not want to participate * patients consulting for acute conditions * patients presenting any diagnosed arrhythmia different than af

Keywords: atrial fibrillation screening
the ec90 of remifentanil blunting hemodynamic changes to head fixation

Conditions: Brain Tumor; AVM; ICH

Summary: the purpose of this study is to estimate the ec90 of remifentanil blunting hemodynamic changes to head fixation in the patients undergoing neurosurgery.


Eligibility criteria:
inclusion criteria: * patients undergoing neurosurgery that require head fixation with mayfield head holder * patients who agree to our study exclusion criteria: * patients who don't agree to our study * bmi\ 30 * cardiovascular disease, pulmonary disease, renal disease * alcoholic abuser or drug abuser * patients who takes any drug having an influence on cardiovascular system or sympathetic nervous system * any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction to peri-fixation period
a study to evaluate 4dct controls

Conditions: Wrist Ligament and Bone Disorders

Summary: the purpose of this study is to use ct motion pictures (4dct) to visualize and record how much space there is between certain wrist joint bones, both without any resistance and with light resistance to the movement, during a single scanning visit.


Eligibility criteria:
inclusion criterion: * age ≥ 18 and ≤ 60 years. * control subjects without any history of wrist injury or disease. exclusion criteria (applied to both wrists for control subjects): * previously-diagnosed rheumatological conditions or connective tissue diseases; * inability to be appropriately positioned in the scanner for the imaging; * congenital malformations of the wrist or forearm; * diagnosed wrist osteoarthritis * age under 18 or over 60.
a nationwide registry study of patients with nonvalvular atrial fibrillation initiating oral anticoagulation therapies in the early period following apixaban marketing in denmark

Conditions: Anticoagulation

Summary: the purpose of this study is to describe the characteristics of patients treated with different oats and whether these characteristics differ between treatments. furthermore to describe persistence to each oat and risk of bleeding after initiating each oat.


Eligibility criteria:
inclusion criteria: the study population will consist of all patients in denmark who meet the following criteria: * adult (≥18 years) at time of anticoagulant initiation * diagnosed with atrial fibrillation without recorded valvular disease * initiated a new oat during the study period (january 1, 2011 and december 31, 2014). * for the identification of nvaf cases, the appearance at least one hospital discharge diagnosis of af will be searched in the databases. exclusion criteria: * patients with prosthetic heart valves , rheumatic mitral or aortic valve disorders, and mitral aortic stenosis will be excluded
hcc surveillance: comparison of abbreviated non-contrast mri and ultrasound surveillance in cirrhotic patients with suboptimal ultrasound visualisation

Conditions: Hepatocellular Carcinoma; HCC

Summary: all international guidelines recommend 6-monthly ultrasound surveillance for patients at risk for liver cancer (hepatocellular carcinoma or hcc), such as patients with cirrhosis. the aim of surveillance is to detect hcc at an early stage when it is still potentially curable. currently only 4 out of 10 hccs are detected at the early stage. ultrasound surveillance for hcc has a wide ranging sensitivity, dependent on many factors such as operator experience, patient body habitus and liver parenchymal heterogeneity due to chronic liver disease and cirrhosis. in a select group of patients, surveillance ultrasound can be suboptimal or near non-diagnostic. currently no guideline offers an alternative surveillance tool for patients who have suboptimal surveillance ultrasounds.

the investigators plan to conduct a prospective study to examine the diagnostic performance of abbreviated non-contrast mri (anc-mri) versus ultrasound, in a select group of cirrhotic patients with poor ultrasound visualisation.

Eligibility criteria:
inclusion criteria * patients with cirrhosis (all causes of cirrhosis, except obscure causes such as vascular or congenital fibrosis) and reduced visualisation of their liver on ultrasound (vb and vc). * the criteria of cirrhosis can be obtained with any of the following methods: 1. histologically by liver biopsy 2. past signs of decompensated liver disease such as ascites, encephalopathy, varices or bacterial peritonitis 3. clinically suspicion of cirrhosis plus one of the following: 1. radiological evidence of morphologic changes of the liver and evidence of portal hypertension on us, ct or mri examinations, including the identification of hepatic surface nodularity, splenomegaly, portal collaterals, varices and ascites 2. fibroscan (transient elastography) median liver stiffness \>12.5 kpa, the fibroscan must be performed by an experienced technician and interpreted by the hepatologist 3. platelet count \<100 (x10\^9/l) with no alternative cause * absence of previous history or current suspicion of hcc - absence of hcc is defined by liver us, multiphase ct or contrast-enhanced mri within 6 months prior to surveillance * patient is able to comply with scheduled visits, evaluation plans and other study procedures in the opinion of the investigator * patient is willing to provide written informed consent exclusion criteria * contraindications to mri scan (defibrillator, pacemaker, metallic foreign body, severe claustrophobia etc.) * contraindications to gadolinium * age above 85 years old or younger than 20 years old * pregnancy or breast feeding * any other condition which, in the opinion of the investigator, would make the patient unsuitable for enrolment for the trial or could interfere with the completion of the study

Keywords: ultrasound mri hcc hepatocellular carcinoma amri nc-amri screening surveillance
echocardiography-guided transthoracic radio frequency/laser ablation for ventricular septum of hypertrophic obstructive cardiomyopathy

Conditions: Hypertrophic Obstructive Cardiomyopathy

Summary: hypertrophic obstructive cardiomyopathy (hocm) patients have significant clinical symptoms, including progressively increasing fatigue, angina, exertional dyspnea, and syncope. conservative medications are used to treat the vast majority of patients. invasive therapy, which includes surgical myectomy, septal ethanol ablation and dual-chamber pacing is introduced to patients with refractory symptoms or drug resistance. considering the sternotomy and relatively high patients' tolerance required in myectomy, the potentially risky misplacement of ethanol and the anatomic variability of the vascularised hypertrophic septum, and the potential risk of conduction block after these two treatments, the development of new minimally invasive approach is warranted. previous researches have illustrated the effectiveness and feasibility of transcatheter radio frequency ablation for hocm patients. by far, there has been no report on transthoracic laser-induced interstitial thermotherapy (litt) for human treatment. since 2004, our department has adopted high intensity focused ultrasound, radio frequency and laser in solid tumors treatment, including liver tumors and fibroid. also our center has conducted several animal experiments to verify the feasibility of radio frequency/laser in septal myocardium ablation. the purpose of this study is to lead echocardiography-guided transthoracic radio frequency/laser ablation for hocm ventricular septum, make minimally invasive treatment plans for hocm patients, and verify the safety and validity of intervention treatment in long term.


Eligibility criteria:
inclusion criteria: * subject who cannot tolerate ventricular septum resection or transcatheter ethanol ablation and volunteer for the operation * subject meets hocm diagnosis standards verified by the echocardiogram; the obstruction is located in the basal part of ventricular septum * subject has significant clinical symptoms, including progressively increasing fatigue, angina, exertional dyspnea, and syncope; subject receives poor effect after drug therapy or cannot tolerate side effects of medication * subject has pressure gradient of left ventricular outflow tract (lvot) ≥50 mmhg（with systolic anterior motion）in the resting-state or after exercise stress test * subject over 18 years old exclusion criteria: * subject has non-obstructive hypertrophic cardiomyopathy * subject has combined cerebral vascular diseases * subject has diseases that must receive surgeries, including severe mitral valve lesions and coronary heart disease which requires coronary artery bypass grafting. * subject has end-stage heart failure * subject has intraventricular septal thickness (ivst) ≥ 30mm
motor imagery in high-risk pregnants

Conditions: Pregnancy, High Risk

Summary: the aim of this study is to determine the acute effects of motor imagery exercises on fetal heart rate, uterine contractions, maternal heart rate, blood pressure, oxygen saturation and well-being in high-risk pregnant women.

bed rest is often recommended in high-risk pregnant women to prevent complications from reaching dangerous levels. pregnant women recommended bed rest can benefit from exercise in order to overcome this process more easily, to reduce the negative consequences of inactivity and to prevent possible risks. however, there may be differences between the view of high-risk pregnant women and the view of healthy pregnant women. motor imagery refers to a mental process in which an individual mentally imagines that movement without actually eliciting an active movement. studies have shown that similar brain regions are activated during movement performance and movement imagery. it has been reported in the literature that progressive relaxation exercises performed under mental/motor imagery guidance in healthy pregnant women and pregnant women lead to an improvement in maternal anxiety, stress and fetal attachment scales and a decrease in maternal systolic/diastolic blood pressure. however, as far as the investigators know, there is no study that applies the exercise protocol that can be given to healthy pregnant women to high-risk pregnant women with motor imagery and examines acute responses on fetal and maternal parameters.

Eligibility criteria:
inclusion criteria: risky pregnant women who have completed the 12th week of pregnancy, received inpatient treatment and have any of the following risk factors will be included in the study: * pregnant women who are at risk for obstetric outcomes such as cervical insufficiency, multiple pregnancy and uncontrolled gestational diabetes, and physical activity restriction is recommended due to these conditions, and exercise is contraindicated, * pregnant women with a maternal body mass index above 30, which causes them to be physically inactive exclusion criteria: * pregnant women who are at risk for obstetric outcomes such as gestational diabetes mellitus and pregnancy-induced hypertension, but physical activity is recommended * pregnant women with severe cardiovascular, pulmonary and systemic disorders * pregnant women with psychological seizure disorders * pregnant women who do not have any mental problems that prevent cooperation and understanding * pregnant women with any medical condition that prevents the safe and effective implementation of interventions. * pregnant women in other high-risk groups (such as early membrane rupture, placenta previa, preeclampsia) that may have early intervention in terms of obstetric outcomes.