Kornimate/medical-research-clean huggingface dataset:
assessing the functional and psychosocial impact of strabismus in asian children using the as-20 and ixtq questionnaires

Conditions: Strabismus

Summary: studies suggest that strabismus has a negative impact on a person's self-image, interpersonal relationships, emotional and psychosocial state (4-15). there are, however, few such studies based in asia, and the functional and psycho-social impact of disease is often neglected in our management of strabismus in singapore. the aim of this pilot study is to measure quality-of-life (qol) among strabismic children in singapore so as to better understand the functional and psychosocial issues faced by these children in their daily living. the investigators also hope to evaluate the performance of the intermittent exotropia questionnaire (ixtq) (2) and adult strabismus quality of life questionnaire (as-20) (1) and to determine if differences between child and parental perceptions exist. 60 children with strabismus presenting to the kkwch eye centre and their parents will be invited to participate in the study and answer questions in 2 pediatric eye disease investigator group (pedig)-validated questionnaires (i.e. the ixtq and as-20). 30 children aged 5-7 years will answer the 12-question ixtq (5-7 years), while 30 children aged 8-16 years will answer the 12-question ixtq (8-16 years) and the 20-question as-20 questionnaires. their parents will answer the self-administered ixtq child-proxy (12 questions), ixtq parental (17 questions) and modified as20 child-proxy questionnaires (20 questions). for comparison, 60 aged-matched children without strabismus or amblyopia (30 aged 5-7 years, and 30 aged 8-16) and their parents will also be invited to answer similar questionnaires (controls). results will be analysed question-by-question and then by composite score, and comparison will be made between child and parental-proxy measures, as well as with scores obtained from myopic children. it is hoped, that from this study, we will be able to assess the usefulness of the ixtq and as-20 instruments as measures of qol in strabismic children, and to assess the feasibility of its use in a larger study looking at the impact of strabismus and its treatment in singaporean children.


Eligibility criteria:
inclusion criteria: 1. children aged 5 to 16 years (inclusive) with strabismus or age-matched controls without strabismus/amblyopia 2. any tropia 3. willingness of children or parents willing to complete questionnaires 4. parents with sufficient reading skills to complete the english written ixtq and as20 5. parent/guardian able to provide informed consent exclusion criteria: 1. children with poor vision (va worse than 6/7.5) in either eye 2. children with any ocular, neurological or syndromic problems 3. children with developmental delay or mental impairment 4. children from overseas (not residing in singapore)
transdermal neuromodulation for management of chronic pelvic pain in women

Conditions: Pelvic Pain Syndrome

Summary: background: chronic pelvic pain (cpp) significantly impacts the quality of life in women. this study investigated the effects of transdermal neuromodulation in females with cpp. trial design: parallel, randomized, single-blind, controlled trial the aim of the study will be to examine the effect of posterior tibial nerve stimulation on women with idiopathic chronic pelvic pain syndrome. methods: thirty females with chronic pelvic pain will be randomly allocated 1:1 to receive either transdermal neuromodulation of the posterior tibial nerve (intervention group) or advice to control posture (control group) for 4 weeks at the outpatient physical therapy clinic at kafrelsheikh university in egypt. the primary outcome was pain intensity measured by visual analog scale (vas). secondary outcomes were serum cortisol level and quality of life (qol) score. assessments will be done at baseline and after 4 weeks.


Eligibility criteria:
inclusion criteria: * nulliparous, with a body mass index not exceeding 30 kg/m2 and complaining of idiopathic chronic pelvic pain syndrome (cpp). exclusion criteria: * chronic uterine prolapse, endometriosis, pelvic tumor, any sexual problems, an active genitourinary infection, heart diseases, kidney diseases, cognitive disorders or any physical or psychological condition that might impair the ability to provide written informed consent or adhere to the research procedure
digital design for maxillofacial prosthetics

Conditions: Prosthetic Treatment; Craniofacial Abnormalities; Maxillofacial Abnormalities

Summary: this study will use a 3d scanner to print a 3d model or mold for each patient's prosthesis. the goal of this study to provide patients with a new, faster method of imaging and creating prostheses that preserves the quality of the current method while reducing time spent by both the patient and providers. patients that are eligible will have a non-invasive 3d scanner (artec space spider) to image the indicated areas of their head and face to help create their new prosthesis. patients will come in for visits as needed to fit and adjust their prosthetic. additionally, patients will be asked to complete questionnaires and have follow-up visits at certain time -points pre and post prosthetic completion.


Eligibility criteria:
inclusion criteria: * maxillofacial anatomic defect or anomaly that limits function or cosmesis (including facial and/or intraoral) * stable defect (no clinically active tumor or plans for major reconstructive surgery) * the patient (or family) have elected to pursue a prosthetic reconstruction of a craniofacial anomaly * the patient is amenable to 3d surface scanning rather than facial molding exclusion criteria: * known allergy to silicone * poor candidate for prosthetic reconstruction * developmental concerns regarding aspiration risk

Keywords: prosthetic treatment rhinectomy
nki therapy compared to usual care of recurrent esophagogastric anastomotic strictures

Conditions: Esophageal Stricture; Anastomotic Stenosis; Dilation of Esophagus Due to Disease

Summary: rationale: the study hypothesizes that nki followed by endoscopic bougie dilation therapy will result in an increased dysphagia-free period, a reduction of endoscopic procedures and dysphagia-related quality of life, and lower costs, when compared with the standard endoscopic bougie dilation (ebd) in recurrent esophagogastric anastomotic strictures. objective: to evaluate the efficacy and cost-effectiveness of needle-knife incision (nki) followed by ebd compared to standard ebd in patients with recurrent esophagogastric anastomotic strictures. study design: this multicenter study is an randomized controlled trial in which nki followed by ebd will be compared with standard ebd. study population: patients with recurrent dysphagia (at least 1 and a maximum of 5 previous dilations) due to an anastomotic esophagogastric stricture that requires treatment with repeated endoscopic bougie dilations. intervention : the intervention to be investigated is the addition of nki therapy to ebd to 18 mm esophageal diameter. main study parameters/endpoints: the primary outcome of this study will be ebd-free time during follow-up of 6 months. secondary outcome parameters will be the number of endoscopic procedures for treatment of dysphagia, quality of life (qol), cost-reduction and cost-effectiveness.


Eligibility criteria:
inclusion criteria: * recurrent intra- or extrathoracic benign esophagogastric anastomotic stricture after esophagectomy. the definition of a stricture is based on the ogilvie dysphagia score (severity of dysphagia), i.e. ogilvie score ≥2 (= ability to swallow semi-solid food or worse (appendix table 1)). * no patency for a standard endoscope (diameter \< 10 mm) * the recurrent stricture has been previously treated with at least 1 to a maximum of 5 ebd sessions that reached an esophageal diameter of ≥16 mm. * the stricture should be suitable for endoscopic incision (stricture length ≤10 mm). exclusion criteria: * benign esophageal stricture other than an esophagogastric anastomotic stricture. * strictures with a morphology unsuitable for nki, such as long (\>1 cm), irregulair or tortuous strictures. * previous endoscopic treatment of the esophageal stricture with steroid injection, incision therapy or stent placement within the past 3 months. * previous stent placement post-esophagectomy for anastomotic leakage. * (suspicion of) locally recurrent or metastasized esophageal cancer. * persisting postoperative esophageal fistula. * inability to discontinue anticoagulants or high-dose antiplatelet drugs at time of the baseline procedure. low-dose aspirin (max. 100 mg/day) may be continued. * known clotting disorder that cannot pre-procedural be corrected.
ball exercises to prevent frailty in older adults (leopard): a pragmatic, open-label, randomized controlled trial.

Conditions: Frailty

Summary: this study aims to examine the effects of a multi-component intervention incorporating swiss ball exercises and nutritional counseling on reducing frailty in a sample of pre-frail older adults in primary care. it also aims to assess its effects on physical performance, functional status, and cognitive and well-being measures. participants aged between 65 and 75 years will be randomly assigned to the intervention group and "usual care" group . over a 3-month period, the multi-component intervention will consist of swiss ball exercises and nutritional counseling, whereas the "usual care" group will get verbal general health counseling on healthy eating and physical activity recommendations. outcome assessors who are blinded to treatment allocation will evaluate primary and secondary outcomes at the end of the intervention (3 months), and after 6 months follow-up period.


Eligibility criteria:
inclusion criteria: age: 65 to 75 years of age frailty status: pre-frail according to the frail scale assessment. ability to rise from a chair without assistance. ability to perform the apley scratch test. ability to bend forward without significant pain. exclusion criteria: hospitalization during the last 3 months. on oxygen therapy. congestive heart failure (chf) with reduced ejection fraction less than 25%. severe aortic stenosis. uncontrolled paroxysmal vertigo. active neoplastic disease or terminal illness. severe cognitive impairment. other neurological disorders (e.g., parkinson's disease, ms). bedridden status. major disability and mobility disorders. chest pain at rest, during activities, or physical activity. loss of consciousness in the past 12 months. advised to avoid vigorous physical activity by a doctor.
repetitive transcranial magnetic stimulation and multi-modality aphasia therapy for post-stroke non-fluent aphasia

Conditions: Stroke; Aphasia, Non-fluent

Summary: many stroke survivors experience aphasia, a loss or impairment of language affecting the production or understanding of speech. one common type of aphasia is known as non-fluent aphasia. patients with non-fluent aphasia have difficulty formulating grammatical sentences, often producing short word fragments despite having a good understanding of what others are trying to communicate to them. speech language pathologists (slps) play a central role rehabilitating persons with aphasia and administer therapy in an attempt to improve communication skills. despite standard therapy, approximately 50% of individuals who experience aphasia acutely continue to have language deficits more than 6 months post-stroke. in most people, broca's area is dominant in the left side of the brain. following a left-sided stroke, the right-sided homologue of broca's area (the pars triangularis), may adopt language function. unfortunately, reorganizing language to the right side of the brain seems to be less effective than restoring function to the left hemisphere. repetitive transcranial magnetic stimulation (rtms), a form of non-invasive brain stimulation, can be used to suppress activity of specific regions in the right side of the brain to promote recovery of function in the perilesional area. despite preliminary success in existing studies using rtms in post-stroke aphasia, there is much work to be done to better understand the mechanisms underlying recovery. responses to rtms have been positive, yet heterogenous, which may be related to timing of treatments following stroke.


Eligibility criteria:
inclusion criteria: * isolated left middle cerebral artery (mca) stroke within past 6 months (sub-acute) or more than 6 months ago (chronic) * stroke type: ischemic or hemorrhagic * non-fluent aphasia as determined by the western aphasia battery (fluency \< 5) * english is first or primary language * ability to follow 3-step commands exclusion criteria: * prior stroke to the right frontal lobe * current diagnosis of moderate to severe depression * diagnosis of any other psychiatric condition * history of other neurologic disorders (e.g., epilepsy, brain tumor) * contraindication to mri or tms (metal in the head or any implanted electrical device) * has received intensive speech therapy within the past 6 months (\>8 hours per week) * enrolled in another interventional study

Keywords: non-invasive brain stimulation transcranial magnetic stimulation multi-modality aphasia therapy neuroimaging
washed microbiota transplantation alleviates diabetic gastrointestinal motility disorders: an efficacy and safety study

Conditions: Diabetic Gastroparesis; Diabetic Gastropathy; Diabetic Gastroenteropathy; Diabetic Gastroparesis Associated With Type 2 Diabetes Mellitus

Summary: the goal of this clinical trial is to learn about effectiveness and safety of washing microbiota transplantation in diabetic gastrointestinal motility disorders participant population. the main questions it aims to answer are: * the risk factors of diabetic gastrointestinal motility disorders in routine clinical data or biochemical tests. * the composition of gut microbiota in diabetic gastrointestinal motility disorders patients and potential pathogenic bacteria. * the efficacy of washing microbiota transplantation in the clinical treatment of diabetic gastrointestinal motility disorders patients and potential factors that may influence treatment outcomes. * the potential mechanisms of washing microbiota transplantation in treating diabetic gastrointestinal motility disorders patients. participants will be collected fasting venous blood and random stool samples before treatment and at week 12 post-treatment, conducting scale assessments before treatment and at weeks 1, 4, and 12 post-treatment.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of type 2 diabetes and diabetic gastrointestinal motility disorder. * glycated hemoglobin (hba1c) \< 11.0%. exclusion criteria: * insulin dependent diabetes; * active infections, antibiotics-using, inflammatory bowel disease, irritable bowel syndrome, or other severe gastrointestinal organic disease; * severe diabetic complications; * thyroid disease, malignancies, severe cognitive impairment and mental disease; * alcohol or substance abuse; * pregnancy or lactation.
proper fractional flow reserve criteria for intermediate lesions in the era of drug-eluting stent

Conditions: Coronary Angiography; Drug-eluting Stents; Fractional Flow Reserve, Myocardial

Summary: angiographic evaluation for intermediate lesions is not always accurate. fractional flow reserve-guided deferral strategy for these lesions showed the same event rate as routine intervention strategy. however, proper ffr criterion for these lesions in the era of drug-eluting stent is not known. this study sought to evaluate the clinical outcomes of intermediate lesions according to ffr and compare those of ffr-guided intervention with routine drug-eluting stent implantation strategy.


Eligibility criteria:
inclusion criteria: * elective pci * angiographically intermediate stenosis (50-75% by visual estimation) in native major coronary arteries, proximal and mid (branch, distal lesion: exclusion) * reference diameter \> 2.5mm, lesion length \< 60mm (cover by 2 stents) * no documented evidence of ischemia by noninvasive tests exclusion criteria: * acute st elevation mi * left main disease * chronic renal failure (cr \>2 mg/dl) * expected survival \< 2yrs * \> 1degree av block

Keywords: intermediate lesion drug-eluting stent fractional flow reserve
a real-world observational study of a mucosal contouring method for radiation-induced oropharyngeal mucositis

Conditions: Radiation-induced Oropharyngeal Mucositis; Swallowing-induced Breakthrough Pain

Summary: the performance of the predictive models for the occurrence and severity of oropharyngeal mucositis established using either oral cavity contouring method or mucosa surface contouring method was unsatisfactory in nasopharyngeal carcinoma (npc). whereas the predictive model of a mucosal contouring method based on swallowing-induced breakthrough pain exhibited better overall performance in locally advanced npc. therefore, the investigators aimed to conduct a prospective, multicenter, real-world observational study to further assess the predictive efficacy of this mucosal delineation method for radiation-induced oropharyngeal mucositis in npc.

swallowing-induced breakthrough pain as a prominent clinical challenge for radiation-induced oropharyngeal mucositis, occurs in almost all patients with nasopharyngeal carcinoma (npc) undergoing radiotherapy, and has a significant impact on patients' quality of life and treatment outcomes. radiation-induced oropharyngeal mucositis is closely related to the irradiated dose and volume, and the performance of the predictive models for its occurrence and severity established using either oral cavity contouring method or mucosa surface contouring method was unsatisfactory. thus, it is difficult to carry out risk assessment, precise screening and early intervention through dosimetric parameters, thereby reducing the occurrence of severe radiation-induced oropharyngeal mucositis. the investigators defined a delineation method based on the mucosal areas of radiation-induced injury resulting in swallowing-induced breakthrough pain in locally advanced npc, and our preliminary results demonstrated that the predictive model exhibited better overall performance. therefore, the investigators aimed to conduct a prospective, multicenter, real-world observational study to further explore the predictive efficacy of this mucosal delineation method for radiation-induced oropharyngeal mucositis in npc.

Eligibility criteria:
inclusion criteria: 1. provide informed written consent. 2. age ≥ 18 years. 3. histologically confirmed as nasopharyngeal carcinoma, and currently undergoing radical radiotherapy or chemoradiotherapy. 4. complete and continuous records of oral / oropharyngeal mucositis grading, and self-reported swallowing-induced breakthrough pain. exclusion criteria: 1. existence of poor oral hygiene, untreated dental or periodontal diseases, and metal dental restorations. 2. current untreated or unresolved conditions like unstable heart diseases requiring treatment, and poorly controlled diabetes mellitus. 3. body mass index (bmi) \<18.5. 4. unsuitable to participate in current study, according to researchers' assessment.

Keywords: nasopharyngeal carcinoma radiotherapy radiation-induced oropharyngeal mucositis swallowing-induced breakthrough pain delineation method
effects of plant based lipids on glucose regulation and cognitive variables

Conditions: Diabete Type 2; Obesity

Summary: the overall goal is to increase the knowledge that can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. more specifically the primary purpose of this project is to evaluate effects in healthy humans on acute postprandial glucose regulation of plant based lipids. due to the tight connection between cardiometabolic health and cognitive functions, a secondary issue is to investigate effects of test foods on cognitive test variables and mood parameters.


Eligibility criteria:
inclusion criteria: * apparently healthy subjects * between 20 and 40 years old * body mass index between 19-28 kg / m2), * consuming a non-vegetarian diet generally in line with the nordic nutrition recommendations. exclusion criteria: * fasting blood glucose concentration \>6.1 mmol/l * known metabolic or gastrointestinal disorder (eg diabetes, high cholesterol, high blood pressure, ibs), or other disease that may affect the study results. * regular medication, except for long-term and stable medication for the lack or reduced production of thyroid hormone (eg levaxin). * antibiotics or probiotics for at least four weeks before the start of the study, * the use of tobacco products
study of kuvan treatment in adults with gtpch deficiency

Conditions: GTP Cyclohydrolase Deficiency

Summary: the purpose of this study is to identify the dose of kuvan needed to normalize the levels of tetrahydrobiopterin (bh4) in patients with a guanosine triphosphate cyclohydrolase (gtpch) deficiency and to asses the potential impact of oral kuvan on mood and function in individuals with gtpch deficiency who may be experiencing symptoms of anxiety, depression, fatigue, trouble concentrating, or memory loss. this will be a phase one study. the investigators will monitor patients over a period of three to six months while on the medication. medication levels will be monitored by measuring the bh4 levels in cerebral spinal fluid (csf). patients will undergo a baseline lumbar puncture and two follow-up lumbar punctures for this purpose. the investigators will also monitor emotional function and motor function.


Eligibility criteria:
inclusion criteria: * established diagnosis of gtpch deficiency, supported by appropriate family history, csf neurotransmitter studies, skin fibroblast enzyme assay and/or mutation analysis * minimum age 18 years * identified by self or others to have symptoms of anxiety, depression, fatigue, or other neurocognitive dysfunction (trouble concentrating, memory loss, etc) * willingness to undergo at least 2 csf evaluations for bh4 and neurotransmitter levels over an 8 to 12 week period exclusion criteria: * age \< 18 years old * unwillingness to undergo repeated csf analysis * lack of supporting diagnostic criteria * concomitant medical problems or medications which would increase risk of kuvan® * concomitant psychiatric state, such as severe depression with suicidal ideation that requires immediate referral and alternative treatment intervention * prior history of back surgery, abnormality or chronic pain that in the opinion of the investigator would increase risks associated with lumbar puncture * significant obesity that might increase difficulty or risk in performing lumbar puncture * if female, unwillingness to use birth control during the period of study drug administration