Kornimate/medical-research-clean huggingface dataset:
effect of inspiratory muscle training during pulmonary rehabilitation on balance in copd patients

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is a respiratory disease that results in progressive airflow limitation and respiratory distress. physiopathological features of copd suggest that people who suffer from this disease have many risk factors for falls that have been identified in older individuals. the benefit of inspiratory muscle training (imt) combined with a pulmonary rehabilitation programme (prp) is uncertain. the investigators aimed to demonstrate that,in chronic obstructive pulmonary disease (copd) patients, imt performed during a prp is associated with an improvement of balance.

chronic obstructive pulmonary disease copd is a preventable and treatable disease(gold, 2017). according to the who, copd would be the third leading cause of death by 2030 (who, 2017). this disease is characterized by airflow limitation that is not fully reversible. the airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases(gold, 2017). however, emerging data showed that copd patients demonstrate important deficits in balance and control which associated to a high risk of fall ( butcher et al, 2004 ; smith et al, 2009 ; beauchamp et al, 2009 ; beauchamp et al, 2010). inspiratory muscle training (imt) has been shown to be an effective modality for copd patients for improving the maximal inspiratory muscle strength, the dyspnea and health-related quality of life (gi copd, 2016). however, the effect of inspiratory muscle training on balance is not studying. the purpose of this study is to evaluate the effect of the inspiratory muscles training on balance in copd patients.

Eligibility criteria:
inclusion criteria: * were copd diagnosed by pulmonary function testing * clinically stable * abscence of other obstructive diseases * signed written consert. exclusion criteria: * were previous pneumonectomy or lobectomy in the past 6 months * spontaneous risk of pneumothorax or rib fracture * incapacity to follow a standard rehabilitation programme (locomotor deficits, acute cardiac failure and acute exacerbation of copd at the beginning of the programme) * the absence of written informed consent.

Keywords: copd imt abc bbs tug sls
opioid free versus opioid based anaesthesia for free flap reconstruction surgery of the breast: a phase iii multicentric randomized controlled study.

Conditions: Breast Cancer

Summary: this study will compare morphine consumption during the first 48 hours postoperatively between the ofa group and the ca control group.


Eligibility criteria:
inclusion criteria: 1. women aged 18 or older. 2. patients with a french health insurance coverage (having a french social security number). 3. patient eligible for free flap reconstruction surgery of the breastunder general anaesthesia. 4. patient who has given written consent to participate in accordance with the regulations. 5. having a negative blood pregnancy test for patients of childbea ring age. exclusion criteria: 1. allergy or intolerance to any of the drugs (dexmedetomidine, remifentanil, lidocaine, propofol, dexamethasone, kétamine, ketoprofen, nefopam, paracetamol, morphine, ropivacaine, droperidol, ondansetron). 2. known history of heart failure, arrhythmias and/or ischemic heart disease and/or severe renal insufficiency. 3. pulse below 50bpm during anaesthesia consultation and/or under beta blocker treatment. 4. treatment with acei/arb. 5. severe asthma. 6. symptomatic gastric or duodenal ulcer with or without treatment. 7. baseline systolic blood pressure \< 100 mmhg. 8. chronic preoperative pain and/or use of who ladder step 2 or 3 analgesics preoperatively. 9. patient already included in another therapeutic trial evaluating an experimental molecule. 10. persons deprived of liberty or under guardianship. 11. patients with suspected difficulties in assessing pain on a scale. 12. inability to undergo trial medical monitoring due to geographic, social or psychological reasons.

Keywords: free flap reconstruction surgery anaesthesia
effect of remimazolam and propofol on postoperative delirium

Conditions: Hip Fractures; Knee Osteoarthritis; Femur Fracture

Summary: remimazolam is an ultra-short acting benzodiazepine agonist which is used widely for general anesthesia and sedation. remimazolam has several advantages. remimazolam is rapidly metabolized by tissue esterase that it does not accumulate even after infusion for long periods of time. the presence of reversal agents (flumazenil) is also advantageous. also, hemodynamic stability compared to propofol gives clinicians preference to use for geriatric anesthesia. however, the study on the effect of remimazolam compared to propofol on postoperative delirium have not been carried out. the purpose of the study is to compare the incidence of postoperative delirium and recovery profile in elderly patients undergoing orthopedic surgery using either remimazolam or propofol.


Eligibility criteria:
inclusion criteria: * elderly patients undergoing hip or knee arthroplasty under general anesthesia. * body mass index \>30 kg/m2 exclusion criteria: * moderate to severe liver dysfunction * moderate to severe renal dysfunction * unable to extubate in the operation room after operation * benzodiazepine dependence * sensitivity to anesthetic drugs used for study (benzodiazepines, propofol, remifentanil, fentanyl citrate, rocuronium bromide, sugammadex, flumazenil) * acute angle glaucoma * received (benzodiazepine, antianxiety drugs, antidepressant, antipsychotic drugs) within 24 hours. * acute psychotic depression * history stroke or cerebrovascular disease
dietary carbohydrate consumption on memory performance and mood in children

Conditions: Cognitive Ability, General

Summary: the purpose of this study is to determine the effect of carbohydrates on blood glucose levels, subjective appetite, mood, and memory performance in 9 to 14 year old normal weight (nw) and overweight or obese (ow/ob) children.

nw and ow/ob children, 9-14 years of age, will participate in the experiment. the effect of 5 different meals (mashed potatoes, hash browns, french fries, rice, or beans matched by 50g of available carbohydrate) and meal skipping will be examined. on six separate mornings, one of the meals or no meal will be provided in a random order upon their arrival. blood glucose, subjective appetite, and mood will be measured at baseline, 10, 30, 60, 120, and 180 minutes after meal consumption. cognitive performance will be measured using an immediate and delayed word recall test, and two to three executive function tasks at 10, 30, 60, 120, and 180 minutes after meal consumption.

Eligibility criteria:
inclusion criteria: * be between 9 and 14 years of age * be healthy, and have been born at term * be a native english speaker * not be taking any medications * not have allergies to potatoes, rice, or beans. * normal body weight (between the 5th and 85th bmi percentile for age and gender) * ow/ob (\>85th bmi percentile for age and gender) exclusion criteria: * food sensitivities, allergies, or dietary restrictions * health, learning, emotional, or behaivoural problems * receiving any medications

Keywords: children dietary carbohydrates solanum tuberosum cognition memory emotions blood glucose
efficacy and safety study of dx-2930 to prevent acute angioedema attacks in patients with type i and type ii hae

Conditions: Hereditary Angioedema (HAE)

Summary: this is a phase 3, multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of dx-2930 in preventing acute angioedema attacks in patients with type i and type ii hae.


Eligibility criteria:
inclusion criteria: * males and females 12 years of age or older at time of screening * documented diagnosis of hae, type i or ii * baseline rate of at least 1 investigator-confirmed hae attack per 4 weeks * adult subjects and caregivers of subjects under the age of 18 are willing and able to read, understand, and sign an informed consent form. subjects age 12 to 17, whose caregiver provides informed consent, are willing and able to read, understand an dsign an assent form. * males and femailes who are fertile and sexually active must adhere to contraception requirements. exclusion criteria: * concomitant diagnosis of another form of chronic, recurrent angioedema, such as acquired angioedema, idiopathic angioedema, or recurrent angioedema associated with urticaria. * participation in a prior dx-2930 study * treatment with any other investigational drug or exposure to an investigational device within 4 weeks prior screening * exposure to angiotensin-converting enzyme (ace) inhibitors or any estrogen-containing medications within 4 weeks prior to screening. * exposure to androgens within 2 weeks prior to entering the run-in period. * use of long-term prophylactic therapy for hae within 2 weeks prior to entering the run-in period. * use of short-term prophylaxis for hae within 7 days prior to entering the run-in period. * any of the following liver function test abnormalities: alanine aminotransferase (alt) \> 3x upper limit of normal, or aspartate aminotransferase (ast) \> 3x upper limit of normal, or total bilirubin \> 2x upper limit of normal (unless the bilirubin elevation is a result of gilbert's syndrome). * pregnancy or breastfeeding.

Keywords: dx-2930 hereditary angioedema dyax
effects of a nutritional solution to improve intestinal permeability in celiac patients

Conditions: Celiac Disease

Summary: celiac disease (or gluten intolerance) is recognized as one of the most common chronic diseases: prevalence of 1 in 100 to 1/300 people in europe and the united states. to date, the treatment consists of a total elimination of any source of gluten from the diet. this eviction generates many daily constraints that would explain that more than 50% of patients do not follow this diet correctly. hidden sources of gluten in a number of foods also carry the burden of this difficulty in effective exclusion. the objective of the protalsafe study is to develop an innovative nutritional approach in the form of a dietary supplement to improve quality of life of patients. the product is not intended to replace a strict gluten-free diet but to propose a nutritional approach in the form of a dietary supplement to improve quality of life of patients. the expected benefits for people consuming the test product are an overall improvement in quality of life and an improvement in biological markers (intestinal permeability, chronic inflammation, etc.) associated with celiac disease.


Eligibility criteria:
inclusion criteria: * celiac disease diagnosis at least 1 year ago * diagnosis proven through biopsy report or general practioner letter or health insurance cover * not following a strict gluten free diet (pavie score 1-3) * covered by health insurance * not in exclusion period from another study exclusion criteria: * pregnant, breastfeeding women or planing pregnancy * gluten intolerance of non celiac origin or any other dietary intolerance of allergy * digestive pathology other than celiac disease * chronic transit problems (diarrhoea or constipation) * uncontrolled pathology * diabetes * medical treatment impacting outcome markers (corticosteroids, nsaids, immune suppressor drugs, pancreatic enzymes, amphetamines) * recent or regular intake of prebiotics, probiotics, food supplements including b vitamins, iron or calcium. * antibiotics in the past month * excessive alcohol intake * drug user * planing to change tobacco use * any other reason why the investigator feels the subject may not be compliant * adults under judicial protection

Keywords: synbiotic nutrition permeability gluten free diet quality of life digestive comfort
amphotericin b treatment in visceral leishmaniasis

Conditions: Visceral Leishmaniasis

Summary: this study is being conducted to assess the safety and efficacy of amphotericin b deoxycholate in doses of 0.75 mg/kg or 1.0 mg/kg for 15 doses. in each arm the drug is given in the conventional way every alternate day against the daily administration regimen being tested.

this study is being conducted to assess the safety and efficacy of amphotericin b deoxycholate in doses of 0.75 mg/kg or 1.0 mg/kg for 15 doses. in each arm the drug is given in the conventional way every alternate day against the daily administration regimen being tested.

Eligibility criteria:
inclusion criteria: * parasitologically proved kala-azar exclusion criteria: * hiv positive serology

Keywords: visceral leishmaniasis amphotericin b kala-azar
dietary reporting in the amyloidoses

Conditions: Amyloidosis

Summary: the goal of this clinical trial is to learn about malnutrition and weight loss in patients with amyloidosis. the main question it aims to answer is: is it feasible to use a low-cost nutrition-based application (apps) for use on a smartphone to obtain detailed information on caloric intake in amyloidosis patients participants will be asked to: * download the myfitnesspal application on their smartphone and view an online tutorial * after a week of practice, from weeks 2-9, participants will enter daily dietary intake as well as daily herbal/alternative supplement intake into the myfitnesspal application on their smartphone. * complete a questionnaire prior to starting the application, after week 2 and at week 10 after starting the application


Eligibility criteria:
inclusion criteria: * 18 years of age or older * diagnosed with any type of amyloidosis * speak, read and write in english * willing to use the myfitnesspal app on their own smartphone exclusion criteria: * a planned autologous stem cell transplant or a solid organ transplant in the 12 weeks after enrollment * cognitive or perceptual disturbances
evaluation of the action of mobiderm® on periarticular edema after total knee prosthesis - randomized controlled

Conditions: Edema; Arthroplasty, Replacement, Knee

Summary: we hypothesize that the use of mobiderm® after total knee prosthesis allows a greater and faster resorption of periarticular edema: * improvement of knee flexion; * faster functional gain; * faster decrease in postoperative pain by decreasing tissue tension.


Eligibility criteria:
inclusion criteria: * patient requiring a first total knee prosthesis (scheduled between tuesday and friday). * patient that has given his/her free and informed consent and signed the consent form. * the patient must be a member or beneficiary of a health insurance plan * the patient is at least 18 years old (≥) and under 90 years old (\<). exclusion criteria: * the subject is in a period of exclusion determined by a previous study (therapeutic study) * the subject refuses to sign the consent * it is impossible to give the subject informed information * the patient is under safeguard of justice or state guardianship * the patient is pregnant or breastfeeding * the patient is allergic to latex bandages. * the subject has contralateral amputation, pressure ulcers, severe obstructive arteriopathy of lower limbs, lymphoedema or thromboembolic event of the lower limb (ipsilateral and / or contralateral / superficial or deep or detected by postoperative doppler). * the subject has chronic or active wounds or any cause that hinders normal rehabilitation or the application of a bandage. * patient with a stroke / disabling neurological pathology, chronic immunological pathology / systemic disease. * patient with hepatic insufficiency. * patient with venous insufficiency (stages 3 and 4). * the patient is on dialysis. * the subject has cognitive or behavioral disorders (parkinson's disease, cerebellar syndrome, opposition, agitation, dementia). * the subject has a history of knee surgery.
effectiveness of phenylefrine in prevention of hypotension during spinal anesthesia for cesarean delivery

Conditions: Hypotension Drug-Induced

Summary: hypotension in patients who are taken to surgery, is a very frequent complication, when the spinal anesthetical technique is used, associating this with significant adverse effects that can lead to morbidity specially in the obstetric patient. the objective of the study is determine if the phenylephrine used of prophylactic form, achieved to prevent the appearance of hypotension in obstetric patients led to caesarea under spinal anesthesia.

worldwide, the caesarean section is one of the surgical procedures most frequently performed, representing a challenge to the anesthesiologist, who must administer anesthesia to the mother with minimal effects in the newborn. for this reason, spinal anesthesia emerges as an important option in the management of the obstetrical patient who is going to be taken to caesarea. the hypotension, is one of the most frequent events adverse associated to this technical anesthetic, represented a risk of complications both, in the mother as in the fetus, by this reason the anesthesiologist must implement different strategies to treat it when this be present. from there arises the necessity of establishing if the phenylephrine, a drug used to treat hypotension, when is administed prophylactically, allows to avoid this effect. we designed a randomized clinical trial in elderly patients over 18 years who are taken to caesarea, where they formed two groups of patients, one that will administer a prophylactic infusion of phenylephrine compared with placebo, assessing the incidence of hypotension in the two groups and the adverse events most commonly associated with this.

Eligibility criteria:
inclusion criteria: * pregnant subjects who are to be delivered to cesarean section under subarachnoid anesthesia * gestational age \>37 weeks exclusion criteria: pregnant subjects with: * hipertensive disorders in pregnancy * acute fetal distress * evidence of placental dysfunction * history of cardiovascular or cerebrovascular diseases * hypersensitivity to phenylephrine * rejection of the patient
prognostic study of major adverse cardiovascular events in patients with coronary artery disease based on metabolomics, and lipidomics (bipass ii)

Conditions: Major Adverse Cardiovascular Events in Patients With Coronary Artery Disease

Summary: to investigate whether there were differences in metabolomics and lipidomics in patients with coronary artery disease who had major adverse cardiovascular events during follow-up compared with those who did not.


Eligibility criteria:
inclusion criteria: 1. hospitalized patients with the diagnosis of any type of coronary artery disease; 2. age ≥18 years of age; 3. patient or guardian provided informed written consent. exclusion criteria: 1. prior surgery, trauma or clinically evident coagulopathic bleeding within the previous 2 weeks; 2. bipass population with missing follow-up records in qilu hospital emergency follow-up cohort.
atfl evaluation with ultrasound in stroke patients

Conditions: Stroke Sequelae

Summary: atfl thickness increases on the affected side of stroke patients and the homogeneous fibrillar structure is deteriorated.we aim to compare morphology of atfl and achilles tendon on the affected and unaffected sides using ultrasound in hemiplegic patients.

age, gender, bmi, time elapsed after the event (months), brunstrom motor stages and barthel activities of daily living index of the patients will be recorded. modified ashworth scale and tardieu scale are used to determine the muscle tone in the gastrocnemius, soleus and tibialis posterior of the hemiplegic side. atfl and achilles tendon will be evaluated using a 12 mhz linear probe of the toshibo aplio 500 usg device.atfl and achilles tendon signal will be evaluated with reference to contralateral features. atfl will be evaluated while the patient lying in the supine position with knee flexion and ankle slight plantarflexion and inversion.the probe will be placed anterolaterally between the lateral malleolus and the talus and a longitudinal image of the atfl is obtained. achilles tendon will be evaluated with the patient lying in the prone position and the ankle at 90 degrees neutral. atfl and achilles tendon signal will be evaluated and noted as homogeneous normal fibrillary structure or heterogeneous.all ultrasound measurements will be performed twice with the patients in the same position.

Eligibility criteria:
inclusion criteria: * patients suffering cerebrovascular accident associated stroke for the first time with a cortical or subcortical unilateral ischemia or hemorrhage * patients over the age of 18 exclusion criteria: * patients who were medically unstable * patients who had botulinum toxin a injection into any muscle in the last 6 months * patients who had other systemic neuromuscular disease * patients who had a previous orthopedic or neuromuscular injury to the lower extremity * patients who had a skin lesion at the measurement site
covid -19 pandemic: economic burden on patients operated for traumatic close fractures

Conditions: Economic Burden

Summary: covid-19 has adversely impacted the health care organizations by over burdening with covid patients and suspending the elective surgeries and clinics a single center retrospective study was conducted to quantify losses due to postponement of elective surgeries and extra cost for procurement of ppes. the secondary objective was to see the effect of covid -19 on the total costs of inpatient care during covid era.

covid-19 has impacted adversely the economy of pakistan that has already poor and challenged socioeconomic conditions this is a single hospital retrospective cross sectional study conducted to quantify losses due postponement of elective surgeries and procurement of ppes and see the effect of covid -19 on the total costs of inpatient care during covid era. we included all the patients admitted in orthopedic section for operative intervention of fractures and elective procedures from january 1, 2020 to may 31, 2020. we divided this period into two halves; the first half was from january first to march 15 named as precovid era and second half was from march 16, to may 31, 2020, termed as covid era. the total number of trauma procedures and elective procedures were compared in both eras. we compared six procedures each from upper and lower limit for cost analysis and length of stay. we also analyzed the extra cost for procurement of ppes.

Eligibility criteria:
inclusion criteria: * all the patients admitted in orthopedic section for operative intervention of fractures and elective procedures from january 1, 2020 to may 31, 2020. exclusion criteria: * patients presenting with other bone morbidities that did not require surgical interventions including rickets, osteomalacia, osteogenesis imperfecta, marble bone disease (osteopetrosis), paget disease of bone, and fibrous dysplasia, patients with incomplete medical records were excluded from the study.

Keywords: economic burden, covid-19 pandemic
phase i study to determine the maximum tolerate dose (mtd) of bgt226 in advanced solid tumors in japan

Conditions: Cancer; Solid Tumor; Advanced Solid Tumor

Summary: this study will confirm safety and tolerability and determine the mtd of bgt226 in japanese patients with advanced solid tumor.


Eligibility criteria:
inclusion criteria: * world health organization (who) performance status of ≤ 2 * histologically-confirmed, advanced solid tumors * progressive, recurrent unresectable disease * age ≥ 20 exclusion criteria: * hematopoietic: * no diabetes mellitus or history of gestational diabetes mellitus * no acute or chronic renal disease * no acute or chronic liver disease * no acute or chronic pancreatitis * no impaired cardiac function or clinically significant cardiac diseases such as ventricular arrhythmia, congestive heart failure, uncontrolled hypertension * no acute myocardial infarction or unstable angina pectoris within the past 3 months * not pregnant or nursing and fertile patients must use barrier contraceptives other protocol-defined inclusion/exclusion criteria may apply.

Keywords: pi3k mtor advanced solid tumor adult