Kornimate/medical-research-clean huggingface dataset:
a multicentre, prospective, non-interventional trial monitoring therapy pathways of asthma patients treated with an extra-fine ics/laba/lama single-inhaler triple therapy in a real-world setting and characterizing the effects on health-related outcomes

Conditions: ASTHMA

Summary: trimaximize, a non-interventional trial aims to collect prospective, longitudinal data from asthma patients under routine care, for whom their treating physician has decided to prescribe trimbow® (beclometasone/formoterol/glycopyrronium).

trimaximize, a non-interventional trial aims to collect prospective, longitudinal data from asthma patients under routine care, for whom their treating physician has decided to prescribe trimbow® (beclometasone/formoterol/glycopyrronium). trimbow is a fixed triple therapy containing a long-acting muscarinic antagonist (lama, glycopyrronium), a long-acting beta-adrenergic agonist (laba, formoterol) and an inhaled corticosteroid (ics, beclometasone). asthma patients often need to use multiple inhalers as part of their therapy, which require different inhalation techniques. it has been shown that the use of several inhalers of different mode of action, design and dosage requirements may have a detrimental effect on patient adherence and subsequent treatment outcomes. in this prospective, non-interventional trial, the investigators aim to evaluate aspects of adherence to trimbow, a single-inhaler triple therapy (sitt) as a maintenance treatment of asthma, to gather knowledge from routine care on whether appropriate step-up to sitt leads to greater adherence and better health outcomes.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age, * patients with confirmed leading diagnosis of asthma with or without concomitant copd, * physician decision to start fixed triple therapy with ics/laba/lama (trimbow® ms or hs) according to its current authorised indication. the treatment decision must be made independently from participation in this nis, * patients willing and able to sign an informed consent for use of their pseudonymised clinical data within the present non-interventional study, * patient must be covered by a social security scheme, * patient must be treated by one of the practitioners of the centre (at office or at hospital). exclusion criteria: * participation in an interventional clinical trial within 30 days prior to enrolment into the present non-interventional study or planned enrolment in an interventional clinical trial during the observational period. * patients unable to understand scope of study or patients unwilling to participate in study.

Keywords: asthma trimbow triple therapy beclomethasone formoterol glycopyrronium trimaximize real-world setting extrafine single-inhaler cohort prospective
multicentre prospective observational study of acute intoxications in paediatric age

Conditions: Acute Intoxication

Summary: acute intoxications represent a major public health problem, especially when affect a population such as children, who are vulnerable and at greater risk of unintentional and preventable poisonings. the primary objective of the study is to assess the epidemiology of acute intoxications in paediatric age with respect to the social and care factors associated with it in order to then implement in the future a better diagnostic-therapeutic management modality on a national level. thi is a prospective non-profit multicentre observational cohort study on acute intoxications in the paediatric age, conducted by amietox, aimed at cavs (poison control centres) and psps (paediatric emergency room).


Eligibility criteria:
inclusion criteria: * subjects between the ages of 1 month and 16 years who report to the psps or contact by telephone the cavs participating in the study with acute intoxication (defined as contact with a substance that is toxic per se or in such quantities as to cause a harmful effect on the body or administered by a route not intended for that substance) exclusion criteria: * not acquired informed consent
evaluation of 3d rotational angiography after evar

Conditions: Radiation Burn; Aortic Aneurysm, Abdominal

Summary: this is a randomized prospective monocentric study to evaluate the benefits of a 3d rotational acquisition (3dra) to assess technical success after treatment of infra-renal aneurysm with bifurcated endograft. patients will be randomized between the standard strategy (2d angiography at the end of the procedure and angioct-scan before discharge) and the new strategy (3dra at the end of the procedure). expected findings are a reduction of radiation exposure and contrast medium used during the hospital stay, with a similar resolution between angioct-scan and 3dra to depict the main complications after evar (occlusion, kinking, endoleak). furthermore, any complication depicted after 3dra group could benefit from an additional procedure during the same operating time, and therefore avoid a second intervention for the patient.


Eligibility criteria:
inclusion criteria: * patients treated with evar for infra-renal aortic aneurysm * in a hybrid room * with a signed consent exclusion criteria: * pregnant women * patients unable to understand the study protocol or to give their consents * renal insufficiency (egfr\<60ml/min) * ruptured aneurysms and other emergency settings

Keywords: hybrid rooms cone-beam computed tomography
effects of virtual reality in adhesive capsulitis on pain, range of motion and function

Conditions: Adhesive Capsulitis

Summary: adhesive capsulitis (ac) also known as frozen shoulder typically manifests to decrease range of motion (rom) and function and increase pain in shoulder. objective of this study is to find the effects of virtual reality (vr) in adhesive capsulitis on pain, range of motion and function to decrease pain and improve range of motion and function. the study design will be a quasi-experimental study that will be used to compare the effects of virtual reality with conventional physical therapy. subjects with adhesive capsulitis meeting the predetermined inclusion \& exclusion criteria will be divided into two groups using lottery method. pre assessment will be done using visual analogue scale (vas), shoulder pain and disability index (spadi) tool and active shoulder flexion and abduction as subjective measurements. subjects in group a will be treated with virtual reality stimulation given for 30 minutes per session through kinetic xbox with sensory accelerator model no.1414. two traditional training activities will be used to improve shoulder range of motion i.e. shoulders finger ladder training activity and single curved shoulder training activity 12 times (3 rounds in each practice) of the training 1 . patients will be required to complete standard training task by interacting with designed vr rehabilitative training games under the supervision of physical therapists and subjects in group b will be treated with conventional physical therapy i.e. grade 1 and 2 mobilization and stretching exercise. baseline treatment protocol hot pack will be applied to both groups. treatment duration for both groups will be 30 minutes. each subject will receive a total 6 week protocol with 02 treatment sessions per week. post treatment reading will be recorded after the end of 2 nd , 4th and 6th treatment weeks. recorded values will be analyzed for any change using spss 21.


Eligibility criteria:
inclusion criteria: 1. age ranges between 25 to 60 2. both gender were included 3. primary idiopathic type 4. no eyesight problems 5. normal cognition and could follow instructions when using the system (score of 20 or more in mini mental state examination) 6. clinically confirmed to ensure frozen shoulders through perform different physical tests i.e. speed tests, empty can test etc exclusion criteria: 1. history of diabetes mellitus 2. any history of previous upper limb fracture 3. received steroids injection in the shoulder 4. any history of systematic or malignant disease

Keywords: virtual reality ,adhesive capsulitis , range of motion
carbetocin versus syntometrine for prevention of postpartum hemorrhage after cesarean section

Conditions: Postpartum Hemorrhage; Blood Loss

Summary: to compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of postpartum hemorrhage after cesarean section

a double blind randomized study conducted on 450 pregnant subjected randomly either to single 100 μg iv dose of carbetocin (150 women) or combination of 5 iu oxytocin and 0.2 mg ergometrine (300 women) after fetal extraction and before placental removal. prevention of postpartum haemorrhage (pph) after cesarean section (cs) had been evaluated by measurement of drop of hemoglobin and hematocrit, incidence of pph and number of subjects needed additional oxytocic

Eligibility criteria:
inclusion criteria: * all participants are at 37 - 40 weeks of gestational age * noncomplicated pregnancy. exclusion criteria: * participants with placenta previa * patients with coagulopathy * preeclamptic women * known sensitivity to oxytocin or methergine were excluded

Keywords: carbetocin syntometrine postpartum hemorrhage cesarean section
eplerenone, aflibercept and topical nepafenac serous foveal deta chment in central serous chorioretinopathy

Conditions: Central Serous Chorioretinopathy

Summary: describing the influence of; combined eplerenone, intravitreal aflibercept, and topical nepafenac; on serous foveal detachment in eyes with cscr

retrospective review of records of eyes with central serous chorioretinopathy (cscr) that have been treated in the period between 2015 and 2021 after checking inclusion and exclusion criteria; we will enroll all cases that have been treated by the combination of eplerenone, intravitreal aflibercept and topical nepafenac. investigators collected and recorded the following data: * age * gender * systemic hypertension (present or not) * smoking (yes / no) * best corrected visual acuity (bcva) (baseline, final) * central macular thickness (cmt) (baseline, final) * serous detachment height (sdh) (baseline, final) * duration of follow-up ( in months)

Eligibility criteria:
inclusion criteria: * cscr eyes treated by combination of eplerenone, aflibercept and nepafenac. exclusion criteria: * • cscr treated by other modalities * cscr treated by just 1 or 2 components of :eplerenone, aflibercept and nepafenac
effect of a tele-rehabilitation programme in children with burns: a randomized controlled trial

Conditions: Burns; Tele-rehabilitation; Scar; Children

Summary: the goal of this clinical trial is to compare tele-rehabilitation and routine post-discharge rehabilitation in children with burn injuries. the main questions it aims to answer are: * is tele-rehabilitation better for improving the quality and outcomes of care for burn children? * is tele-rehabilitation more effective in improving scar management in children with burns injuries? * is tele-rehabilitation more effective in improving perceived stress in parents of children with burns injuries?

in this study, experimental group received a 12-week tele-rehabilitation program, which included face-to-face access to silicone pads, pressure garments, splint and other tools necessary for burn recovery. the tele-rehabilitation program was used for intervention and regular follow-up. the control group also received a 12-week follow-up, but only on the basis of face-to-face access to silicone pads, pressure garments, splint and other tools necessary for burn recovery. researchers will compare whether the trial group has better the quality and outcomes of care and scarring for children and parents who perceived stress.

Eligibility criteria:
inclusion criteria: * inclusion criteria are based on the recommendations of the american burn association. * child suffered from burn injury 3-6 years old and had survived the burn event. * the burn severity quantified by the total body surface area（tbsa）burned is equal or more than 1%. * tbsa burned is the estimated proportion of the body with second or third degree burns. * burns involving neck, trunk，limbs and face. * only chinese parents will be recruited. exclusion criteria: * 1.insufficient parental chinese language proficiency required to complete questionnaires. * parents cannot use social software (such as wechat, qq, etc.) for video, picture, and text communication after discharge. * the main caregiver is someone other than the parents. * children did not live at home with their parents, such as hospitalization, boarding school, etc. * children who are receiving rehabilitation treatment. * children who have other severe disease, like cerebral palsy.

Keywords: tele-rehabilitation parental stress scar management quality of life
anesthesia type on percutaneous nephrolithotomy in aging male

Conditions: Kidney Stone; Anesthesia

Summary: the aim of this study is to compare the anesthesia methods in percutaneous nephrolithotomy in terms of safety and effectiveness in elderly men.

data recorded since 2003 will be analyzed retrospectively. elderly men with pnl will be divided into two groups according to the type of anesthesia. the results determined in both arms will be compared with appropriate statistical methods.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of renal stone disease * above 65 years of age * male sex exclusion criteria: * having low hemoglobin level before surgery * presence of hematology disease causing bleeding diathesis * presence of stones in an ectopic or transplanted kidney
platelet-rich plasma (prp) for endometrial regeneration and repair

Conditions: Infertility; Asherman's Syndrome

Summary: patients with intrauterine adhesions (asherman's syndrome) and persistent thin endometrial lining in in vitro fertilization (ivf) treatment programs, particularly those resistant to standard therapies, present a significant clinical challenge. the aim of this trial is to assess if intrauterine administration of platelet rich plasma (prp) improves endometrial lining thickness in patients with thin lining or asherman's syndrome.

background: there is a need for new and more effective therapies for patients with intrauterine adhesions (asherman's syndrome) and persistent thin endometrial lining in in vitro fertilization (ivf) treatment programs, particularly for patients resistant to standard therapies hypothesis: platelet rich plasma stimulates cellular processes involved in endometrial regeneration relevant to management of a thin lining or intrauterine scarring. primary aims: - to measure the change in endometrial lining thickness secondary aims: * to determine if fertility is improved in patients receiving platelet rich plasma (prp): 1. in patients with thin lining undergoing frozen embryo transfer (fet), to determine: * clinical pregnancy rate 2. in patients with asherman's syndrome, to determine: * the chance of spontaneous pregnancy any adverse effects of study arm will be monitored and reported as appropriate.

Eligibility criteria:
inclusion criteria: * persistent thin lining \ 1 cycle in previous ivf or fet cycle or moderate-to-severe asherman's syndrome exclusion criteria: * age \ 43 years old, * pregnancy, * diagnosis of cancer, * hb \<11 g/dl, platelets \<150,000/mm3, * anticoagulation, * nsaids in the 10 days before procedure * any significant comorbidity or psychiatric disorder that would compromise patient safety or compliance, interfere with consent, study participation, follow up, or interpretation of study results. * incision in the uterus: myomectomy; cesarean section

Keywords: endometrium thin uterine lining uterine scarring
monitored vs standard supplementation of vitamin d in preterm infants

Conditions: Vitamin D Deficiency; Osteopenia; Nephrolithiasis; Drug Overdose

Summary: the purpose of this study is to determine wheather the monitored vitamin d (vit d) therapy is safer and more effective than standard therapy in pretrem infants.

vitamin d (vit d) deficiency is a risk factor of osteopenia of prematurity, which leads to rickets or decreased bone mass mineral density. recently multiple studies have been published on vit d adjust biological functions. dosage, safety and effectiveness of vitd supplementation in preterm infants still remains a controversial topic. we hypothesize that monitored supplementation of vit d is more effective and safer than standard therapy 500iu in preterm infants. the study will be carried out in 138 preterm infants, born at 24-32 week of gestational age (ga) at the princess anne's hospital in warsaw, poland. we will determine if monitored supplementation of vit d decreases the incidence of vit d deficiency and/or overdosing at 40 week (ga). for secondary objective we shall assess if monitored therapy reduces the incidence of vit d deficiency and/or overdosing at 35, 52 week (ga), prevalence of osteopenia, low bone mass, nephrocalcinosis and nephrolithiasis.

Eligibility criteria:
inclusion criteria: * preterm infants born between 24 and 32 weeks of gestation (estimated by ultrasound) * in born or admitted to the unit within 48hours from birth. * randomization within 7 days from birth. * parental consent. * mothers willing to return for follow up visits. exclusion criteria: * preterm delivery \>=33 weeks of gestation or term delivery (estimated by ultrasound). * major congenital abnormalities. * participation in another trial. * severe illness at birth deemed incompatible with survival. * congenital hiv infection. * total parenteral nutrition \> 14 days. * cholestasis

Keywords: vitamin d supplementation hydroxyvitamin d pretrem infants osteopenia
the feasibility study of dual-section nasogastric tube

Conditions: Stroke; Mouth Neoplasms

Summary: the purpose of this studyis to assess the feasibility and safety of novel designed two-piece nasogastric tube.


Eligibility criteria:
inclusion criteria: * dysphagia * mouth neoplasms * stroke * already use conventional nasogastric tube for at least 2 weeks exclusion criteria: * unconsciousness patient * unstable medical condition with needs of closely medical care * unable to fill in inform consent * the fixed length was less than 50 or more than 60 centimeter when using conventional nasogastric tube
urinary protein to creatinine ratio in term pregnant women

Conditions: Pregnancy Complications

Summary: this study will determine the incidence of elevated u pr/cr in normal term pregnant women. in addition we will determine if a "clean catch" urine has an effect on the u pr/cr.

clean catch urine should be used due to possible vaginal secretion contamination with falsely elevated u pr/cr ratio. however, no supporting reference was found in the article and no control group with random urine collection for comparison to clean catch specimen u pr/cr was included in their study. the original studies that validated spot pr/cr urine as a predictor of 24 -hour total urine protein used random non-clean catch random urines . they had an r value of .93-.99 in estimating total protein excreted in 24 hours. at our institution we use siemens-base test to determine u pr/cr. in the product insert the company states that no special patient preparation is necessary. thus, this study will determine the incidence of elevated u pr/cr in normal term pregnant women. in addition we will determine if a "clean catch" urine has an effect on the u pr/cr.

Eligibility criteria:
inclusion criteria: * women of 37 weeks gestation or greater exclusion criteria: * urinary tract infections * hypertension * pre-eclampsia * renal dysfunction
movement analysis in musculoskeletal oncology: a pilot study

Conditions: Motion Analysis in Musculoskeletal Oncology

Summary: noninterventional, prospective, multicenter pilot study of patients with primary and secondary musculoskeletal tumors designed to investigate functional outcomes after therapy using both subjective and quantitative motion detection techniques


Eligibility criteria:
inclusion criteria: * age \> 6 years * diagnosis of primary and secondary tumors of the musculoskeletal system * patients who will need to undergo surgery for bone resection or wide excision of soft tissue lesion, and/or radiation or drug treatments * availability of follow-up data (for at least 6 months) * written informed consent exclusion criteria: - inability to perform pre-post treatment assessment
study to investigate immunogenicity, efficacy and safety of treatment with human-cl rhfviii

Conditions: Severe Hemophilia A

Summary: the purpose of the study is to collect long-term data on the inhibitor development rate of human-cl rhfviii in previously untreated patients with severe hemophilia a.


Eligibility criteria:
inclusion criteria: 1. patients who completed gena-05 in accordance with the study protocol exclusion criteria: 1. severe liver or kidney disease 2. concomitant treatment with any systemic immunosuppressive drug; 3. other fviii concentrate than human-cl rhfviii was received between completion visit of gena-05 and start of gena-15 (except emergency cases).
effect of stitch technique on the occurrence of incisional hernia after abdominal wall closure

Conditions: Injury of Abdominal Wall

Summary: the major long term complication of abdominal wall closure after a median laparotomy is the development of an incisional hernia. several suture technique and suture material have been used but the incidence of this complication still lies between 9 -20%. synthetic suture material which have become available over the last decades have the advantage that they are degraded by the body system and fully absorbed within 70-180 days; however they loss 50% of their initial strength already after 14-30 days and may not be the optimal suture material for abdominal wall closure. a new suture material (monomax®) was developed with an extra-long absorption profile, high elasticity and with a superior initial strength. therefore, the estoih-study was designed to investigate the influence of the stitch length on the occurrence of incisional hernia using the extra-long term absorbable, elastic, monofilament suture (monomax®).


Eligibility criteria:
inclusion criteria: * age ≥18 years * patients undergoing an elective, primary median laparotomy with an incision length of ≥ 15 cm * expected survival time longer than 1 year * asa i-iii * written informed consent exclusion criteria: * emergency surgery * patient undergoing surgery due to a pancreas carcinoma * patients who will be operated due to an abdominal aortic aneurysm * peritonitis * coagulopathy * current immunosuppressive therapy (more than 40 mg of a corticoid per day or azathioprin) * chemotherapy within the last 2 weeks before operation * radiotherapy of the abdomen within the last 6 weeks before operation * pregnant women (pregnancy test has to be performed) * severe neurologic and psychiatric disease * lack of compliance

Keywords: laparotomy short stitch long stitch monomax
calf muscle strength and standing efficiency in children with spastic diplegia

Conditions: Cerebral Palsy

Summary: it will be hypothesized that strengthening the calf muscles will improve standing efficiency in children with spastic diplegia.


Eligibility criteria:
inclusion criteria: * children age will be ranging between 2 and 4 years. * they are classified at level iii by gmfcs-er, i.e. they can stand with minimal support. * full mobile lower limbs joints. * children with mild and moderate spasticity ( i.e. grade 1 and 2, according to modified ashworth scale). exclusion criteria: * children with severe spasticity ( i.e. grade 4, according to modified ashworth scale). * fixed deformities. * uncontrolled seizures.

Keywords: cerebral palsy standing strengthening