Kornimate/medical-research-clean huggingface dataset:
the impact of fish oil supplementation on the outcome of children with pneumonia i

Conditions: Pneumonia

Summary: the aim of study is to investigate the effect of enteral feeding of omega-3 on the outcome of children with pneumonia in picu

group a(cases) will be supplemented by omega-3 fatty acids for immediate post admission consecutive 7 days besides conventional treatment of pneumonia, in a dose of 350 mg twice daily for children less than 3 years and 450 mg twice daily for older children according to the standard treatment per the american institute of medicine of the national academies guidelines for maximum dose for this age group. (institute of medicine of the national academies,2016) side effects of omega-3 supplements are usually mild. they include unpleasant taste, bad breath, bad-smelling sweat, headache, and gastrointestinal symptoms such as heartburn, nausea, and diarrhea. (office of dietary supplements ,2016) group b(controls) will be received enteral feeding without omega-3 fatty acid support.

Eligibility criteria:
inclusion criteria * all children patients with severe pneumonia admitted to picu * both sexes * age: under 5 years * whose parents or caregivers approve for participation in the study exclusion criteria * patients with chronic illnesses to exclude bias that could be emerged due to the chronic disease effect * whose parents or caregivers will not apply for participation in the study * patients who will be contraindicated for enteral feeding
effect of 3d-printed reconstruction system in size of left dlt

Conditions: Cancer of Lung; Lung Isolation

Summary: the precise and accurate size of dlt is a prerequisite to ensure its accurate position of its placement. three-dimensional (3d) reconstruction technology can accurately reproduce the tracheobronchial structure to improve the correct size selection of dlt. to make it simpler, the investigators developed an automatic comparison software for 3d reconstruction based on computed tomography data (3dracs). in this study, the investigators aimed to prove that 3dracs is much more efficient in endobronchial intubation compared to the traditional method.

lung isolation techniques are commonly used to facilitate surgical exposure and to provide single-lung ventilation for patients undergoing various intra-thoracic procedures. lung isolation is primarily accomplished with a double-lumen tube (dlt) or bronchial blocker. one published study showed that residents with limited experience had a 40% error rate in accurately placing a dlt. the accurate choice of the size of dlt is a prerequisite for good lung isolation.currently, there is lack of proper objective criteria for selecting size of dlt. dlt size selection is estimated empirically using the patient's height and sex, and studies have shown that the size of dlt according ct images of the chest is more accurate than experience. the investigators have developed an automatic comparison software for 3d reconstruction based on ct data (3dracs). it reconstructs the trachea and bronchus and compares them with the dlt, predicting the most suitable size of the dlt for lung isolation. the aim of this study was to compare whether the use of 3dracs to select a dlt size compared to conventional empirical selection methods could improve incidence of dlt intubation success and reduce airway injury.

Eligibility criteria:
inclusion criteria: 1. aged between 18 and 75 years. 2. american society of anesthesiologists physical status (asa-ps) i-iii. 3. planned to receive lung resection surgery during lung isolation techniques by using dlt. 4. signed informed written consent. exclusion criteria: the participant experiences any of the following： 1. spinal malformation, 2. expected difficult airway 3. tracheal stenosis 4. tracheal tumor 5. bronchial tumor 6. distorted airway anatomy 7. tumors of the mouth or neck

Keywords: lung isolation double-lumen tube three-dimensional reconstruction
stool-based sdc2 dna methylation test for the detection of colorectal advanced adenomatous polyps and cancer

Conditions: Colorectal Cancer; Colorectal Adenomatous Polyp; Screening

Summary: the primary objective is to compare the performance of stool-based sdc2 dna methylation test and commercially available fecal immunochemical test(fit) , on the detection rate of advanced adenomatous polyps and colorectal cancer in chinese population. subjects with positive results in either test will receive colonoscopy. lesions will be confirmed as malignant or precancerous by colonoscopy and histopathologic examination.

a large cohort of participants will be asked to collect stool sample for either stool-based sdc2 dna methylation test or fecal immunochemical test. subjects who have positive results will undergo colonoscopy within 6 months. representative histopathology slides from tissue biopsied or excised during colonoscopy and those from subsequent definitive surgery may be retrieved in order to be evaluated by pathologists to confirm the diagnosis and staging.

Eligibility criteria:
inclusion criteria: 1. subject is average risk for development of colorectal cancer. 2. subject is able and willing to undergo a screening colonoscopy within six months of enrollment. 3. subject is 45 to 80 years of age inclusive. 4. subject is able to comprehend, sign, and date the written informed consent document to participate in the study. 5. subject is able and willing to provide stool samples according to written instructions provided to them. exclusion criteria: 1. subject has any condition which, in the opinion of the investigator should preclude participation in the study. 2. subject has a history of colorectal cancer or adenoma. 3. subject has a history of other digestive tract cancer.

Keywords: colorectal cancer screening sdc2 dna methylation fecal immunochemical test
pesticide exposure pathways for farmworker children

Conditions: Poisoning

Summary: this project is aimed at better understanding how children living in agricultural environments are exposed to pesticides, and how such exposures can be prevented or reduced. the current project will characterize pesticide exposure pathways for children of farmworkers.

this project is aimed at better understanding how children living in agricultural environments are exposed to pesticides, and how such exposures can be prevented or reduced. since 1991 our group has investigated pesticide expsoures among children of agricultural families in washington state, focusing on exposure to organophosphate insecticides. we have demonstrated in these studies that the residential environments of agricultural families have higher pesticide residues than do other homes in this region. we have also found that children living in these residential environments have elevated levels of pesticide metabolites in their urine. we need to better understand how these children are being exposed in order to develop recomendations for exposure prevention or reduction. the current project will characterize pesticide exposure pathways for children of farmworkers. a complementary project is also underway by the uw-child health center to develop and implement a community-wide intervention to reduce the transfer of pesticides from the workplace to the home (take home pathway).

Eligibility criteria:
each family recruited must include one child between the ages of 1-5.

Keywords: pesticide insecticide organophosphate exposure child health
nursing activity and quality of hospitalized patients' sleep

Conditions: Sleep Disorders, Circadian Rhythm

Summary: this study is to determine the impact of night shift nurse's activity on patients' sleeping patterns in medical services including individual, clinical and environmental factors. the patients will be questioned in order to create both a control group and a group with troubled sleeping patterns.

there are 5 speciality medical units involved. patients must respond to the define inclusion criteria. each patient will be asked if they agree to participate and if so will be asked to consent to participate. every day, nurses will give a questionnaire which will be completed by the patient to know if there were troubles sleeping patterns. if so, a second questionnaire will be completed by the patient. other data will be recorded such as personal informations, diagnostic, medical history, consumption habits and treatments. the inclusion phase lasts 15 days maximum.

Eligibility criteria:
inclusion criteria: * patient hospitalize in medical units * in the unit since one night * patient over 18 years old * patient agree to participate exclusion criteria: * patient who can't answer to the questionnaire for health reasons * patient who need a specific surveillance * patient recently operated
evaluation of vss antibiotic prophylaxis in prosthetic surgery (mrsa)

Conditions: Infection in Bone

Summary: based on international guide lines, antibiotic prophylaxis in orthoaedic major surgery has to be done with a cephalosporin 1st generation (e.g. cefazolin 1 g 30' before surgery). since more than 10 years ago the investigators started evaluatinf infections in such a surgery, well demosntrating a level below 1% and, more important, a responsability of mrsa. considering cephalosporin 1st generation useful but not determinat in such a surgery, investigators consider the use of a glycopepide (vancocyn 1 g in very short. the primary outcome is to evaluate the validity of such proposal, performing a study of prevalence.

patients enrolled in the study have to follow rhese steps: t0: clinical evaluation and cephalosporin vss prophylaxis, as usual t1: surgery for tka or tha t2: post-operative --\> control and, if an infextion is supposed, coltural examination and abg t3: post-op orthopedic control at 6 months, to evaluate any possible infection t4: post-op clinical valuation at 12 months, with the same goal

Eligibility criteria:
inclusion criteria: patiens male and female, old more than 40 years tka or tha surgeryntervento di chirurgia protesica asac ii or even iii, without any acute coexisting disease informed consent - exclusion criteria:patients with infection before surgery immunocompromise patient (e.g. diabeties with glicate hb indicating a metabolic bad compensation) patient with coagulation disorders pregnancy informed consent denied -
cross-cultural adaptation, reliability and validity of the turkish version of the headache disability questionnaire

Conditions: Headache; Headache Disorders; Headache, Migraine; Headache, Tension; Headaches Chronic; Headaches Muscular

Summary: the purpose of this study was to investigate cultural adaptation, reliability and validity of the turkish version of the headache disability questionnaire (hdq).

when the outcome criteria for the physiotherapy of headache are considered in clinical studies and practice, parameters such as headache frequency, duration and severity are frequently used. physiotherapists treat musculoskeletal dysfunction in various types of headache, including migraine, tension headache, and cervicogenic headache. the headache disability questionnaire (hdq), which was developed to measure the quality of life of a general population receiving physiotherapy and experiencing headache, evaluates the pain intensity, daily life activities, disruptions in work or school life, and the influence of the recreational activities of individuals. hdq consists of 9 items and each item is rated between 0 and 10. increasing the score indicates the seriousness of the impact. the study is planned with 45 individuals with gluteal tendinopathy. after questioning the sociodemographic characteristics of the individuals, the patients will be asked to fill in hdq, migraine disability assessment questionnaire, headache impact test-6 and short form-36.test-retest will be re-applied to those of the same individuals who can be reached after 1 week. the results will be analyzed using the spss version 22.0 computer package program.

Eligibility criteria:
inclusion criteria: * diagnosed with any type of headache, * have a chronic headache. exclusion criteria: * having a cognitive and neurological disorder.

Keywords: headache reliability validity cross-cultural adaptation
5-htr2a, drd2,and comt genes polymorphisms and olanzapine plasma concentration in treatment of early-onset schizophrenia

Conditions: Early-onset Schizophrenia

Summary: in this study,investigators will recruit 100 dsm-ⅴdefined eos han patients, older than 7 years old and onset of illness before 17 years old, and all eos patients will receive a 8-week systematic olanzepine titration treatment and a battery of assessments of treatment effect and safety. blood olanzepine plasma concentration will be tested regularly and genotyping of 8 polymorphisms of 5-htr2a, drd2 and comt genes will be conducted by polymerase chain reaction （pcr）, restriction fragment length polymorphism (rflp) and taqman probes genotyping technology. the aim of the study is to explore the predictive factors on olanzepine treatment response in eos, which can guide the individualized treatment and improve the cure rate of eos in clinical setting.

early-onset schizophrenia (eos) is the world health organization ranked psychosis as the third most disabling condition worldwide in youth, and may lead to obvious social dysfunction and interfere seriously with neurodevelopmental processes in a young person, which in turn has the potential to irreversibly alter the trajectory of his or her life. to improve the outcome of the patients of eos, elaborate and individualized therapeutic regimen is urgently needed. the functional gene polymorphisms and drug (antipsychotics) plasma concentration can both influence the drug response, but few studies explore the contributions of genetic heterogeneity, drug plasma concentration and clinical features of patients to drug response together and interactions of above factors in eos patients. in this study investigators will recruit 100 dsm-ⅴdefined eos han patients, older than 7 years old and onset of illness before 17 years old, and all eos patients will receive a 8-week systematic olanzepine titration treatment and a battery of assessments of treatment effect and safety. blood olanzepine plasma concentration will be tested regularly and genotyping of 8 polymorphisms of 5-htr2a, drd2 and comt genes will be conducted by polymerase chain reaction （pcr）, restriction fragment length polymorphism (rflp) and taqman probes genotyping technology. the aim of the study is to explore the predictive factors on olanzepine treatment response in eos, which can guide the individualized treatment and improve the cure rate of eos in clinical setting.

Eligibility criteria:
inclusion criteria: * above 7 years old, * age of onset ≤17 years old, * han or other nationality, male or female, * in line with the diagnostic dsm-v criteria for schizophrenia, and * negative and positive symptom scale (positive and negative syndrome scale, panss) score ≥70 points; * patients are in the condition of first-episode, or relapse. exclusion criteria: * iq \<70, * current or previous history of traumatic brain injury, * psychoactive substance use, * personality disorders, * obvious abnormalities on physical and laboratory examination, * previous allergy or olanzapine had significant adverse reactions.

Keywords: genes polymorphisms plasma concentration
relationship between the vegf gene polymorphism and cardiometabolic risk factors

Conditions: Polymorphism, Restriction Fragment Length

Summary: the aim of the study is to determine the relationship between vegf gene expression, vegf gene polymorphism and serum leptin concentration in the polish population in people with excessive body weight. in addition, the aim of the study is to look for relationships between the vegf gene polymorphism and anthropometric and biochemical factors of cardiovascular risk and endothelial dysfunction such as body weight, waist circumference, serum total cholesterol, ldl, hdl, triglycerides, glucose and the occurrence of cardiovascular diseases in the family of a patient with excessive body weight in the polish population.

400 people (250 - study group; 150 control group) were subjected to subjective and objective action. information on the occurrence of diseases and cardiovascular risk in the participant and his family was collected from research studies. anthropometric parameters were measured (body weight, height, bmi, waist circumference, neck circumference) as well as blood pressure and pulse measurement. in addition, fasting venous blood was collected and secured. in venous blood currently marked with the following concentration: glucose, required cholesterol, ldl cholesterol, hdl cholesterol and triglycerides. in addition, a method of salting out and protecting dna was developed from blood. furthermore the polymorphisms of vegf genes (in positions: -2578 and -634) using the hmr (high resolution melt) method was determined. also vegf and leptin by elisa was determined. after obtaining the results of comparative analysis of the correlation between the occurrence of vegf gene polymorphisms, serum levels of leptin and vegf, and anthropometric and biochemical parameters of cardiovascular risk.

Eligibility criteria:
inclusion criteria: * informed consent in writing * stable body mass (+/- 1 kg) * excessive body mass (bmi ≥ 25 kg/m2- study group) * proper body mass (bmi \< 25 kg/m2- control group) exclusion criteria: * age \<18 years * secondary obesity * pregnancy, lactation * other conditions that in the opinion of researchers may pose any risk to the patient during the study.

Keywords: vegf gene expression vegf gene polymorphism leptin
effect of nebulized dexmedetomidine on post-dural puncture headache

Conditions: Post-Dural Puncture Headache

Summary: dural puncture during neuroaxial procedures is the most frequent major complication that causes the development of post-dural puncture headache (pdph) in 16%-86% of cases. pdph could be defined as severe positional headache that usually presents during the first 72-h following accidental dural puncture. dexmedetomidine (dxm) is a potent and highly selective α2-adrenergic agonist that was approved for icu and procedural sedation in adults. additionally, dxm has pleiotropic effects for its sympatholytic, amnestic, and analgesic properties. regarding routes of administrations, dxm allows high flexibility and can be administered through intravenous (iv), intramuscular, buccal, intranasal and inhalational routes. nebulized dxm at 1 µg/kg is a favorable alternative to the intravenous route in short duration surgeries because it attenuates heart rate response to laryngoscopy. however, the effects of nebulized dxm on blood pressure are controversial. it was assured that it has a role in reduction of the intraoperative anesthetic requirements and analgesic consumption. the prophylactic and management strategies for pdph are heterogeneous because of the absence of clear guidelines and protocols for the management of pdph. however, the general plan for pdph management consists of conservative treatment and if failed invasive procedures such as blood patch were applied.


Eligibility criteria:
inclusion criteria: * women had cs under spinal anesthesia; * women started to complain of pdph; * women were free of exclusion criteria. exclusion criteria: * women had prior history of pdph or headache for any cause; * women had essential hypertension; * women with previous history of habitual hypotension or accidental syncope secondary to postural hypotension; * women with tempromandibular disorders; * women who refused to participate in the study were excluded.
oxidative stress and l-cbmn cytome assay in obese after 3 weeks vlcd

Conditions: Obesity; Weight Loss; DNA Damage

Summary: obesity leads to physiological imbalance resulting in hyperglycemia, dyslipidaemia and inflammation and can generate systematic oxidative stress through multiple biochemical mechanisms. oxidative stress (os) can induce dna damage and inhibit dna repair mechanisms. very low calorie diet (vlcd) have rapid positive effect on weight loss, glucose homeostasis, insulin resistance, inflammation and os. the aim of this study is to determine the effect of a three-week vlcd on anthropometric, biochemical and genomic parameters in individuals with bmi ≥ 35kg/m2.

obesity is a complex chronic multifactorial disease associated with concomitant or increased risk for chronic inflammation, insulin resistance, dyslipidemia, oxidative stress, type 2 diabetes, cardiovascular disease, stroke and multiple cancer types. oxidative stress (os) can cause permanent dna damage which could be detected with lymphocytes cytokinesis-block micronucleus (l-cbmn) cytome assay. weight loss and improvement of dietary habits in people with obesity can affect genome stability and have beneficial effects on insulin sensitivity, inflammation and os. effects of very low calorie diet (vlcd) on dna damage are scarce. the aim of this study is to determine the effect of a three-week vlcd used in special hospital for extended treatment of duga resa in patients with bmi ≥ 35kg/m2 on permanent dna damage, lipid profile, insulin resistance, inflammation and anthropometric parameters.

Eligibility criteria:
inclusion criteria: * body mass index ≥ 35 kg/m2 exclusion criteria: * pregnancy * actual tumor diseases * recent diagnostic or treatment exposures to ionizing radiation in the period of one year * individuals not willing to stay 3 weeks under supervision under full 24 h surveillance from the medical stuff

Keywords: obesity very low calorie diet oxidative stress micronuclei apoptosis
comparison of two multifocal contact lenses

Conditions: Presbyopia

Summary: the purpose of this study is to compare two multifocal contact lenses in presbyopic wearers.


Eligibility criteria:
inclusion criteria: * at least 35 years of age. * sign written informed consent * spectacle add of +0.50 to +2.50d. * best corrected visual acuity of at least 20.30 in both eyes. * currently wearing soft contact lenses at least 5 days per week. * other protocol-defined inclusion criteria may apply. exclusion criteria: * eye injury or surgery within twelve weeks of enrollment. * currently enrolled in any clinical trial. * astigmatism \> 1.00d. * strabismus/amblyopia. * other protocol-defined exclusion criteria may apply.