Kornimate/medical-research-clean huggingface dataset:
a comparative, controlled study to evaluate the clinical accuracy of the velieve u.s. uti urine analysis test system

Conditions: Urinary Tract Infections

Summary: the velieve u.s. uti urine analysis test system (henceforth velieve u.s.) is composed of a kit and a smartphone application. the device will be provided to the subject in a simulated home-use environment. all subjects will be asked to complete the urine test by following the application guidance,including providing a urine sample and scanning the urine strip after placing it on the color-board. the user will also complete a questionnaire to collect information regarding the use of the velieve u.s. device. following the usability test performed by the lay user, the subject's urine sample will be tested by the professional user using the comparator device. the use of the velieve u.s. device will be evaluated for identified risks. additionally, measurable usability criteria for specific, critical steps will be evaluated.


Eligibility criteria:
inclusion criteria: * males and females 18-80 years of age; * subjects who are healthy or: * subjects with a medical condition that normally present with an abnormal concentration of leukocytes, nitrites and blood: (examples of such conditions include the following): * urinary tract infection (uti) * patients with suspected or known occult blood in urine * pregnant women * other relevant conditions * subjects with any pathological findings which might be identified by the urine test (according to the physician discretion) * subject is capable and willing to provide informed consent; * subject has facility with both hands; * subject is capable and willing to adhere to the study procedures. * subject is familiar with the use of a smartphone * subject is capable of comprehending and following instructions in english exclusion criteria: * subject has dementia. * subject has mental disorders. * subject cannot collect urine in a receptacle. * subject is visually impaired (cannot read the user manual). * any additional reason the study physician believes disqualifies the subject from participating in the study.
preload dependency evaluation with stroke volume variation during alveolar recruitment manoeuvres

Conditions: Coronary Artery Disease; Coronary Artery Bypass; Hypovolemia; Anesthesia, General; Pulmonary Atelectasis

Summary: the principal aim is to assess impact of alveolar recruitment manoeuvres (arm) on stroke volume variation, evaluated by trans-oesophageal echocardiography (tee). these variations will be measured on preload dependency or preload independency status. the principal purpose is to determine if variations of stroke volume during standardized arm can predict the preload dependency status.

population studied: anesthetized patients for cardiac surgery of coronary bypass. secondary endpoints : - comparison between tee and mini-invasive monitoring systems in accuracy of measurement of stroke volume variation during arm. these mini-invasive systems are : clearsight system (edwards lifescience) and flotrac system (edwards lifescience) - difference between pre and post-cardiopulmonary bypass status on principal purpose evaluation

Eligibility criteria:
inclusion criteria: * adult patient undergoing a surgical procedure of coronary artery bypass, with cardiopulmonary bypass written consent collected exclusion criteria: * emergency case * pericardial effusion * aortic or mitral valvulopathy * contraindication for : tee, alveolar recruitment manoeuvre (emphysema, pneumothorax, hemodynamic instability), ringer lactate solution infusion * bad echogenicity * patient refusal to participate to the study * no health insurance

Keywords: alveolar recruitment manoeuvre lung recruitment preload dependency cardiac surgery transoesophageal echocardiography
pharmacokinetics, safety and tolerability of oral semaglutide in subjects with various degrees of impaired renal function

Conditions: Diabetes; Diabetes Mellitus, Type 2; Healthy

Summary: this trial is conducted in europe. the aim of the trial is to investigate the pharmacokinetics (the exposure of the trial drug in the body), safety and tolerability of oral semaglutide in subjects with various degrees of impaired renal function compared to subjects with normal renal function.


Eligibility criteria:
inclusion criteria: * male or female aged 18-85 years (both inclusive) at the time of signing inform consent * subject with normal renal function or renal impairment (mild, moderate, severe or end-stage renal disease requiring dialysis) * for subject with normal renal function: good general health (as judged by the investigator) * body mass index (bmi) 18.5-40.0 kg/m\^2 (both inclusive) exclusion criteria: * female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using adequate contraceptive methods * history of crohn's disease, ulcerative colitis, or other inflammatory bowel disease * uncontrolled hypertension (defined as systolic blood pressure above or equal to 180 mmhg and/or diastolic blood pressure above or equal to 100 mmhg) * any blood draw or donation of blood or plasma in excess of 400 ml within the 3 months preceding the screening visit (visit 2) * history of significant drug abuse, or a positive drug test at the screening visit (visit 2)
clinical and pathological characteristics of women with ovarian cancers in syria

Conditions: Ovarian Cancer

Summary: the goal of this observational study is to describe ovarian cancer epidemiology and characteristics in syrian women, especially during the war to do more research in the future about the risk factors of ovarian cancer.

ovarian cancer (oc) is the eighth most common cause of death worldwide, and current studies show that the death numbers caused by it will rise dramatically in the coming years. as the epidemiological features of the cancer may vary, studying these different characteristics can help us improve treatment outcomes and add preventive measures. in addition, giving special attention to these features in developing countries, or countries undergoing crisis, will help us understand the associated risk factors in these regions.

Eligibility criteria:
inclusion criteria: * female adult (age ≥18 years) * primary ovarian malignancy exclusion criteria: * less than 18 years old * women who have benign tumors or metastatic ovarian cancer.
sevoflurane versus propofol in endovascular coiling of cerebral aneurysm

Conditions: Propofol; Sevoflurane

Summary: the goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. the main question it aims to answer is: does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage? participants already undergoing endovascular coiling of cerebral aneurysm will have their serum levels of inflammatory factors measured.


Eligibility criteria:
inclusion criteria: * consecutive patients aged 18 years and older presenting to the tongji hospital for endovascular coiling of cerebral aneurysm were eligible for enrollment. exclusion criteria: * have an endocrine system disease * pregnancy * have other brain disorders * take drugs that alter endocrine hormones * receive perioperative blood derivatives
quantitative evaluation of aerosols produced in the dental office

Conditions: Aerosol Disease; Caries,Dental

Summary: background: maintaining biosafety in dental practice requires an efficient elimination of aerosols produced during dental treatment. the objective of this research was to assess the quantity of aerosols and aerobic bacteria present in the air during the treatment of caries. methods: this study was divided into two groups based on the caries treatment method involving 60 patients with 60 m olar teeth (n=60) in the mandible. group 1 (n=30) received a conventional dental turbine w\&h synea ta-98lc (w\&h, bürmoos, austria), while group 2 (n=30) received an er:yag laser (lightwalker, fotona, slovenia). measurements of aerosol particles between 0.3 - 10.0 μm near the operator's mouth were taken using the pc200 laser particle counter (trotec gmbh, schwerin, germany). the number of aerobic bacteria in the air was determined using 60 micro-biological plates with a microbiological medium (columbia agar with 5% sheep blood) and the sedimentation method. a control group g3 was established to measure the initial aero-sol level and the initial total number of bacteria cfus (colony-forming units) before each treatment.


Eligibility criteria:
inclusion criteria: - the subjects were chosen for the study under the subsequent inclusion criteria: occurrence of medium or profound caries on black class i, icdas 3,4 exclusion criteria: * patients with systematic diseases that can influence the treatment of periodontitis * patients under or took antibiotics 2 months. * patients under or took immunosuppressors the last 6 months. * pregnant or lactating woman.

Keywords: laser er:yag disinfection bacteria high-volume evacuator
the effect of manual acupuncture and standard therapy on anxiety and quality of life scores in cancer patients

Conditions: Anxiety; Quality of Life; Cancer

Summary: the goal of this clinical trial is to prove that the combination of acupuncture therapy and standard therapy is more effective in reducing anxiety and improving the quality of life of cancer patients. the main questions it aims to answer are: 1. can the combination of manual acupuncture and standard therapy reduce anxiety based on hamilton anxiety rating scale (ham-a) scores in cancer patients compared to the sham acupuncture and standard therapy group? 2. can the combination of manual acupuncture and standard therapy improve the quality of life of cancer patients based on the european organization for research and treatment of cancer quality of life questionnaire c-30 (eortc-qlq c30) compared to the sham acupuncture and standard therapy group? participants will: get manual acupuncture therapy and also standard therapy, such as oral benzodiazepin and supportive psychotherapy or sham acupuncture therapy and the standard therapy (benzodiazepin and supportive psychotherapy) every day for 6 days. researchers will compare the changes of anxiety scores and quality of life between cancer patients who received manual acupuncture therapy and standard therapy, and cancer patients who received sham acupuncture and standard therapy.


Eligibility criteria:
inclusion criteria: * patients aged 18-59 years. * diagnosed with cancer in the last 6 months * experiencing moderate to severe anxiety (assessed by ham-a score \> 24) * willing to participate in this study until completion and sign an informed consent. exclusion criteria: * cancer patients with unstable hemodynamics * cancer patients with brain metastases * patients who have been diagnosed with anxiety disorders and have received pharmacological therapy from psychiatrists before. * patients who have contraindications to manual acupuncture (there are wounds or infections at the point to be punctured, patients are allergic to stainless steel, patients are phobic of needles) * patients who are uncooperative and do not allow acupuncture therapy (patients who are restless, angry) * patients with poor liver function (sgot (serum glutamic oxaloacetic transaminase) /sgpt (serum glutamate pyruvate transaminase)values increase 2-3 times the normal value) * patients with blood clotting disorders (platelets \ 2) * patients with neutropenia (absolute neutrophil count \<1000) * patients with overt dic (disseminated intravascular coagulation) and acute venous or arterial thrombosis
lphp-philos-phn conservative treatment

Conditions: Proximal Humeral Fracture

Summary: the aim of the study is to compare the results regarding fracture healing and functional outcome after the treatment of proximal humeral fractures with the four different treatment methods after 12w./6months and 12 months based on radiological evaluation as well as the "constant score" and the "neer score".

evaluation of proximal humeral fractures using a new stable-angled implant.

Eligibility criteria:
inclusion criteria: * fractures of proximal humerus * age over 18 years * completed skeletal development * fracture less than 5 days old exclusion criteria: * open fractures * pseudoarthrosis, pathological or refractures * ipsilateral fractures of distal humerus or elbow * polytraumatic conditions * pregnancy * subject with known history of diseases that influence the healing process * alcohol, drug abuse

Keywords: humerus fractures locking plates nail system
clinical impact of mi on inhaled antibiotic adherence in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: adherence to treatment is a major challenge in cystic fibrosis (cf). motivational interviewing (mi) is increasingly used to address this, but its effectiveness is unknown. we investigated the clinical impact of an mi intervention, delivered by a specifically trained pharmacist, on adherence to inhaled antibiotics (ia).

adherence to treatment is a major challenge in cystic fibrosis (cf). motivational interviewing (mi) is increasingly used to address this, but its effectiveness is unknown. we investigated the clinical impact of an mi intervention, delivered by a specifically trained pharmacist, on adherence to inhaled antibiotics (ia). adults with cf were recruited through the regional cf centre. a pharmacist trained in mi delivered three recorded mi sessions over 2 months, with follow up at 3, 4 and 6 months. demographics, ppfev1, bmi, adherence (ia collection rates) and additional antibiotic use were collected during the study and for 6 months prior. treatment quality and satisfaction (tqsm), self-reported adherence (moriskey medication adherence scale-8 (mmas-8)), quality of life (cf questionnaire-revised (cfq-r)) and sputum pseudomonas aeruginosa (pa) density were assessed at each study visit. statistical analysis compared outcomes pre and post-intervention and variation during the intervention period.

Eligibility criteria:
inclusion criteria: 1. male or female patients with a documented diagnosis of cf aged ≥18 years on the date of informed consent 2. known chronic infection with pa, as defined by the leeds criteria 3. has been prescribed inhaled colomycin and/or tobramycin and/or aztreonam for a minimum of 3 months prior to study enrolment 4. able to provide written informed consent 5. able to understand and comply with protocol requirements and instructions 6. has been identified by the physician during routine appointments as having difficulties with adherence to their inhaled therapies exclusion criteria: 1. patients that do not expectorate sputum spontaneously 2. inability to complete questionnaires
effect of pea fiber supplementation on the gut microbiota and host metabolome and proteome (fib)

Conditions: Microbial Colonization

Summary: all subjects will complete a 49-day, multi-phase feeding study to evaluate the effect of pea fiber supplementation on gut community structure and features of host biological state (plasma proteome/ metabolome). subjects will be asked to continue to consume their habitual diet (free diet phase) for 4 days prior to being provided with a diet high in saturated fat (hisf) and low in fruits and vegetables (lofv) in the form of packed-out meals and snacks to consume for the following 45 days. ten days after starting to consume the hisf-lofv diet, subjects will supplement their diet with pea fiber for a total of 21 days; the energy contribution from the hisf-lofv diet will be reduced accordingly to maintain energy needs during this time. after completing the pea fiber supplementation phase of the study subjects will revert back to consuming the hisf-lofv only diet for the final 14 days. stool, urine and blood will be sampled periodically throughout.


Eligibility criteria:
inclusion criteria: * bmi 25.0-35.0 kg/m² * presence of b. vulgatus and b. thetaiotaomicron each at greater than 0.01% relative abundance exclusion criteria: * previous bariatric surgery * significant organ system dysfunction (e.g. diabetes, severe pulmonary, kidney, liver, or cardiovascular disease) * cancer or cancer that has been in remission for less than 5 years * major psychiatric illness * inflammatory gastrointestinal disease * pregnant or lactating women * use of medications that are known to affect the study outcome measures * use of medications or supplements known to affect composition of the gut microbiota within the last 30 days (e.g. antibiotics) * bowel movements less than 3 times per week * vegans, vegetarians, and those with allergies, aversions, or sensitivities to foods provided in the study * persons that are not able to grant voluntary informed consent * persons who are unable or unwilling to follow the study protocol or who the research team deems not an appropriate candidate for the study.
intraarticular distal radius fractures, x-fix or volar fixation

Conditions: Dorsally Displaced Intraarticular Distal Radius Fractures; Age 50 - 74 for Females or 60-74 for Males; Low Energy Trauma

Summary: distal radius fractures are treated surgically if severely displaced. this study aims to investigate the outcome after surgery. the investigators will randomize patients to either external fixation with optional addition of k-wires or open reduction and fixation with a volar plate.

this study has been merged with nct 01034943 and a new permit has been issued by the swedish national board on ethical permits

Eligibility criteria:
inclusion criteria: * female 50-74 years or male 60-74 years * dorsally displaced intraarticular distal radius fracture * dorsal angulation \>20 degrees measured from the plane perpendicular to the radius axis * low energy trauma * injury \<72 hours when diagnosed * patient independent of help for adl exclusion criteria: * earlier dysfunction in any wrist * other major injuries * rheumatoid arthritis or other systemic joint disease * dementia or severe psychiatric disease * severe medical condition making general anesthesia a major risk

Keywords: radius fracture wrist external fixation volar plate dash prwe
erector spinae plane block for pediatric idiopathic scoliosis surgery

Conditions: Scoliosis Idiopathic

Summary: the study aims to assess the effect of the interfacial plane blocks on the pain level, the course of postoperative rehabilitation, and its anti-inflammatory analgesic effect.

this study evaluates the analgesic efficacy in adolescents of bilevel, bilateral erector spinae plane (esp) blocks after posterior spinal fusion surgery by assessing postoperative pain scores and opiate requirements as the primary outcome measures. we aim to investigate how esp blocks, performed under ultrasound guidance at the two vertebral levels, contribute to postoperative pain control. this will be determined by measuring numerical rating pain scores repeatedly following surgery and opiate consumption until the patient is discharged from the hospital. these primary outcome measures will be compared between a treatment group of participants receiving esp blocks and a control group receiving a sham block. our primary hypothesis is that esp blocks significantly reduce postoperative pain and opiate requirements.

Eligibility criteria:
inclusion criteria: * age 10-18 years old * pediatric patients who will undergo the surgical correction of idiopathic scoliosis exclusion criteria: * a history of chronic pain (use of gabapentin/pregabalin for \> 3 months or opioid use \> 1 repeated opioid prescription in the last three months) * morbid obesity (bmi \> 99th percentile) * previous surgery * back abnormalities * infection at block application area * coagulopathy

Keywords: pain management peripheral nerve block erector spinae plane block euromonitoring
study of broader efficacy of atomoxetine in the treatment of adhd in children/adolescents

Conditions: Attention Deficit Hyperactivity Disorder

Summary: to test the hypothesis that children/adolescents with adhd, who are treated with atomoxetine hydrochloride in comparison to standard current therapies have greater improvements in their quality of life.


Eligibility criteria:
inclusion criteria: * diagnosis of adhd exclusion criteria: * patients who weigh less than 20kg at visit 1 * have bipolar disorder/seizure disorder/taken anticonvulsants for seizures * judged to be at suicidal risk * taking psychotropic medication on a regular basis * hypertension
effects of spinal manipulation on vertebrobasilar and internal carotis arteries in healthy population

Conditions: Vertebral Artery Dissection, Traumatic; Neck Pain

Summary: after lumbar pain, neck pain is the most common cause of patients needing chiropractic care; the second most common cause of spinal manipulation use (1). manipulation and mobilization are commonly used by chiropractors, osteopaths and manipulative physiotherapists in the treatment of neck pain. many studies show that the activator instrument is also used for this purpose in the chiropractic profession (2) there are several published case reports that relate to neck manipulation to vertebral artery dissection and stroke. the prevailing theory is that the neck extension and / or rotation may damage the vertebral artery in the foramen transversarium, especially at the c1-c2 level (2). however, most cases of extracranial vertebral artery dissection are thought to be spontaneous (3). in the literature, there have been no studies investigating the effects of instrument-assisted spinal manipulation on vertebrobasilar and internal carotis arteries. the aim of this study to compare the effect of manual and instrumental spinal manipulation on blood flow parameters of vertebrobasilar and internal carotis arteries on healthy persons which have mechanical neck pain and asymptomatic in vertebrobasilar insufficiency test.


Eligibility criteria:
inclusion criteria: * being between 20-40 years of age * having non-specific mechanical neck pain for more than 3 months with symptoms provoked by neck postures, movements, or palpation * willingly participating to the study * signing the confirmation form. exclusion criteria: * spinal root compression (radiculopathy) * neurological symptoms like weakness and numbness in extremities and face, uncontrolled movements, abnormal gait, dizziness, undefined nausea/vomiting, swallowing and speaking difficulties * acute inflammatory disease * spontaneously vertebral artery dissection in family * tested positive in premanipulative vertebrobasilar artery insufficiency test * being on anticoagulant and antiaggregant medication.

Keywords: chiropractic, manipulation, vertebrobasilar artery