Kornimate/medical-research-clean huggingface dataset:
urgent (<24 hours) versus early (24 to 48 hours) ercp for patients with mild and moderate acute cholangitis

Conditions: Acute Cholangitis

Summary: acute cholangitis is an emergency associated with significant morbidity and mortality which require prompt recognition and treatment. the decompression of biliary tree along with antibiotics are mainstay of therapy. randomized comparative studies showed that ercp achieves biliary decompression with markedly less morbidity and mortality compared with surgery, regardless of clinical drainage. percutaneous trans hepatic drainage (ptbd) can be alternative to endoscopic drainage in selected group especially advanced hilar strictures and patients who are unfit for endoscopic procedure. recent asge guidelines suggested the performance of ercp within 48 hours for patients with acute cholangitis; however it is conditional recommendation with very low quality of evidence. till date, no randomized trial has compared urgent ercp versus early ercp for acute cholangitis.


Eligibility criteria:
inclusion criteria: * patients who met criteria for a definite diagnosis acute cholangitis. exclusion criteria: * patients with severe acute cholangitis at admission. * age \< 18 years. * pregnancy. * associated acute severe pancreatitis. * patients with suspected high grade (bismuth iii/iv) biliary stricture in whom ptbd is considered as primary method of biliary drainage. * not giving consent.
fast food photo study

Conditions: Obesity

Summary: the investigators aim to discover if people of different demographic levels are more or less attentive to changes in calorie information vs. changes in price information on a restaurant menu. the investigators will record whether the calorie/price change was noticed or not, as well as how quickly the calorie/price change was noticed, depending on condition and individual differences.

participants complete a short study regarding their ability to detect "mistakes" in a printed version of a fast food restaurant menu. we ask participants to identify the differences between the menu board and a typical menu board at that location. individuals list the differences that they find and have a chance to win a prize if they identify the most mistakes among participants recruited that day. the differences created will remain constant (e.g., featuring pepsi products instead of the typical coca-cola offerings, including items from other restaurants on the menu), including changes to calorie labels and price labels. additionally, we recruit participants in a variety of locations to test for differences between demographics (e.g., income groups, education levels, and bmi levels).

Eligibility criteria:
inclusion criteria: * age 18 or older * speaks english * willing to complete both task and follow-up survey exclusion criteria: * n/a

Keywords: calories fast food literacy
a feasibility study of internet delivered prolonged exposure

Conditions: Post Traumatic Stress Disorder

Summary: the primary objective with this study is to investigate the feasibility and acceptability of ten weeks of internet delivered prolonged exposure delivered through a digital platform with therapist support. the secondary objective is to investigate preliminary effects of internet delivered prolonged exposure in terms of reducing symptoms of post-traumatic stress, depression and increase quality of life.

the investigators will investigate internet delivered prolonged exposure delivered as a ten-week treatment comprising of six modules (psychoeducation/rational, in vivo exposure, imaginal exposure, common problems during exposure, hot spots and relapse prevention). the feasibility and acceptability and preliminary effects of treatment- and assessment procedures will be evaluated using a within-group design with repeated measurements and qualitative interviews. recruitment is designed to be broadly inclusive with minimal exclusion criteria. patients will be recruited from a psychiatric clinic specialized in ptsd in stockholm, sweden and by advertisements in newspapers and social media.

Eligibility criteria:
inclusion criteria: * currently primary diagnosis ptsd according to dsm-5 diagnostic criteria for ptsd * ≥ 18 years * fluent in swedish * signed informed consent exclusion criteria: * ptsd is not the primary concern * initiation or adjustment of any psychotropic medication within the last 4 weeks prior to commencement of treatment * ongoing substance dependence * current suicide risk meriting crisis intervention * psychotic disorder * ongoing trauma-focused psychological treatment * ongoing trauma-related threat (e.g. living with a violent spouse)

Keywords: prolonged exposure internet-delivered ptsd
efficacy and tolerability of antistax® in male and female patients suffering from chronic venous insufficiency

Conditions: Venous Insufficiency

Summary: study to assess the efficacy and tolerability of antistax® film-coated tablets in patients with chronic venous insufficiency (cvi, clinical condition, etiology, anatomic location, pathophysiology (ceap) classification: clinical class 3, or 4a)


Eligibility criteria:
inclusion criteria: * male or female * 18 years of age or older * cvi, clinical class 3 (oedema) or 4a (mild skin changes ascribed to venous disease, e.g. pigmentation), according to the ceap classification * willing and able to give written informed consent prior to participation in the study exclusion criteria: concomitant diseases: * decompensated cardiac insufficiency * oedema not due to venous disease of the legs (e.g., latent cardiac insufficiency, renal insufficiency, lymphoedema, etc) * peripheral arterial disease (ankle/arm pressure index \< 0.9) * current acute phlebitis or thrombosis * renal insufficiency (serum creatinine \> 1.5 mg/dl) * liver disease (sgpt \> 3x upper limit of normal) * other diseases: hyper- or hypocalcaemia, malignancies * anamnestic indications of diabetic microangiopathy or polyneuropathy * drug and/or alcohol abuse * severe climacteric complaints: changes in, or initiation with post-menopausal hormone replacement therapy within the last 3 months * immobility * avalvulia * klippel-trénaunay-weber-syndrome (naevus varicosis osteohypertrophicus, haemangiectasia hypertrophicans) * state after pulmonary embolism * recognised hypersensitivity to the trial drug ingredients * current florid venous ulcus * clinical indication for a necessary, specific phlebologic acute treatment, e.g. compression treatment, phlebectomy, etc. previous treatments: * patients who are on compression therapy and/or are wearing support stockings and who optimally benefit from these measures * treatment with venous drugs within the last 2 weeks prior to the intake of study medication * changes in or unstable response to treatment with theophylline, diuretics, cardiac glycosides, ace inhibitors, calcium antagonists, or laxatives within the last 2 weeks prior to the intake of study medication concomitant treatment/non-drug therapy exclusion criteria: * other venous drugs apart from the trial medication * venous surgery or sclerotherapy within the last 12 month at the leg used for volumetry * extensive use of laxatives * major surgery requiring full anaesthesia other exclusion criteria: * previously studied under this protocol * participation in another clinical trial within the previous 90 days or during the present study * patient is investigator, co-investigator, or study nurse in this study * pregnant or nursing women or inadequate birth control methods (this applies to females of childbearing potential only) * patients considered as mentally ill as well as unable to work or with limited working ability, or unable (or only partially able) to follow the spoken or written explanations concerning the trial * patients in a bad general health state according to the investigator's judgement
development of a talk therapy protocol to help patients make treatment decisions in ms

Conditions: Relapsing-remitting Multiple Sclerosis

Summary: between 15-20% of ms patients decide not to initiate disease modifying therapies after being diagnosed with ms. for this study, we will develop a telephone-based talk therapy intervention and then conduct a randomized controlled trial. patients will be assigned to either 5 weekly 20 minute telephone sessions of psychotherapy or a brief education control condition. we hypothesize that patients undergoing phone therapy will be more likely to indicate they are interested in initiating disease modifying medications than patients given brief education and treatment as usual.


Eligibility criteria:
inclusion criteria: * diagnosis of relapsing remitting ms based on established guidelines * not taking recommended therapy * provider recommendation for dmt use * at least 18 years of age * access to a telephone * english speaking exclusion criteria: -

Keywords: multiple sclerosis disease modifying medication relapsing-remitting ms motivational interviewing telephone counseling
brief nurse-led mindfulness based intervention

Conditions: Pain; Osteoarthritis, Knee; Osteoarthritis, Hip

Summary: this is a single-site, two-arm, parallel-group randomized clinical trial (rct). the feasibility, acceptability, and clinical effects of the nurse-led, very brief, preoperative mindfulness based intervention for hip and knee replacement patients will be investigated relative to nurse-led preoperative pain psychoeducation. a secondary sub-analysis will compare two different styles of mindfulness practice (mindfulness of breath vs. mindfulness of pain) relative to preoperative pain psychoeducation.


Eligibility criteria:
inclusion criteria: * 1) age ≥18, * 2) scheduled to undergo unilateral total knee arthroplasty exclusion criteria: * 1) cognitive impairment preventing completion of study procedures. * 2) current cancer diagnosis, * 3) contralateral knee replaced in the previous 3 months, * 4) intent to have contralateral knee replaced or other, additional surgical procedure during the study period, * 5) intent to add new pain treatments during the study period (except for what is part of the study), * 6) other unstable illness judged by medical staff to interfere with study treatment.
quilt-2.013: first-line treatment for extensive stage small cell lung cancer

Conditions: Lung Cancer; Small Cell Lung Cancer; Solid Tumors; Extensive-stage Small Cell Lung Cancer

Summary: this trial is titled "a phase 1b/2 trial of amg 479 or amg 102 with platinum-based chemotherapy as first-line treatment for extensive stage small-cell lung cancer (sclc)." part 1, the phase 1b portion of this study, is a multicenter, open-label investigation to identify safe dose levels of either amg 102 or amg 479 in combination with etoposide plus cisplatin or carboplatin in subjects with previously untreated extensive stage sclc. part 2, the phase 2 portion of this study, is a multicenter, double-blind, 3-arm investigation to evaluate overall survival of either amg 102 or amg 479 in combination with platinum-based chemotherapy.


Eligibility criteria:
key inclusion criteria * histologically or cytologically confirmed sclc * extensive disease, defined by at least one of the following: * no limited disease (ie, no disease confined to the ipsilateral hemithorax, which can be safely encompassed within a tolerable radiation field) * extrathoracic metastases * malignant pericardial or pleural effusion * contralateral hilar adenopathy * measurable or nonmeasurable disease, as defined by modified recist * eastern cooperative oncology group (ecog) status 0 or 1 * ≥18 years old * life expectancy (with therapy) ≥3 months * adequate hematologic, hepatic, coagulation, renal, and metabolic function * diabetes, if present, must be controlled, with glycosylated hemoglobin (hba1c) ≤ 8% and fasting glucose levels ≤160 mg/dl key exclusion criteria * prior chemotherapy, chemoradiation, or investigational agent for sclc * prior radiotherapy to \>25% of the bone marrow * symptomatic or untreated central nervous system metastases (with exceptions) * currently or previously treated with biologic, immunologic or other therapies for sclc * current serious or nonhealing wound or ulcer * history of prior concurrent other malignancy (with exceptions) * thorombosis or vascular ischemic events within the last 12 months such as dvt, pe, tia or mi * any clinically significant medical condition other than cancer (eg, cardiovascular disease or copd), which could interfere with the safe delivery of study treatment or risk of toxicity

Keywords: extensive disease extrathoracic metasasis malignant pericardial effusion malignant pleural effusion contralateral hilar adenopathy
innovative approaches for minor consent: consent 2.0

Conditions: HIV

Summary: the purpose of this study is to examine how the consent process affects the acceptability of participation in biomedical hiv prevention trials, from the perspective of behaviorally high-risk minors and the parents of minor adolescents.

potential participants will be recruited from clinical settings and hiv testing centers. if interested in participation, they will take a short computer assisted self-interview (casi) screening survey to determine eligibility. those eligible will take part in the one-day study visit at that time or will provide contact information to set up the study visit at a later date. all study participants will attend a one-day study visit at their respective study site. upon arrival, participants will complete a casi that collects demographic, social, behavioral, and attitudinal measures. next, participants will take part in a simulated consent process for two hypothetical trials modeled after atn 113 and hptn 077. study procedures differ for adolescents and parents, so each group is described separately below: adolescent participants: for each hypothetical trial, research staff will lead the participant through a simulated consent process consistent with their randomized consent condition. then, the participant will complete a casi assessing willingness to participate (wtp) and will work with research staff to complete the university of san diego (ucsd) brief assessment of capacity to consent (ubacc). parent participants: for each hypothetical trial, research staff will review the informed consent forms with the parent. the parent will complete a casi with three vignettes that describe each of the three possible consent conditions. parents will rate the acceptability of each vignette. then, the participant will work with research staff to complete the ucsd brief assessment of capacity to consent (ubacc). finally, the participant will answer a series of questions via casi. a subset of 6-8 adolescents and 6-8 parents per study site will complete a debriefing interview assessing adolescent and parent perspectives on the various consent conditions in greater depth, and to better understand the role of study features, family, and adolescent characteristics in willingness to participate/willingness to support the hypothetical research studies.

Eligibility criteria:
note: age limits apply to adolescent participants and to the adolescent children of parent participants. adolescent inclusion criteria * age 14-17 inclusive * able to read and speak english * hiv status is negative or unknown * engaged in high-risk sexual activity in the last six months adolescent exclusion criteria * child of a parent already enrolled in the study parent inclusion criteria * able to read and speak english * parent or guardian of an adolescent who is between ages 14-17 * the parent/guardian's adolescent's hiv status is either negative or unknown parent exclusion criteria * parent of a child already enrolled in the study
cortisol and the formation of intrusive memories

Conditions: Intrusive Memories

Summary: intrusive memories of traumatic events are core features of posttraumatic stress disorder (ptsd) but little is known about the neurobiological formation of intrusions. the aim of this study was to determine whether cortisol levels during an intrusion-inducing stressor influence subsequent intrusive memories.

the investigators conducted an experimental, double-blind, placebo-controlled study in 60 healthy women. prior to watching an established trauma film paradigm that induces short lasting intrusions, participants received a single dose of either 10 mg hydrocortisone or placebo. the number of consecutive intrusions of the trauma film, the mean vividness of the intrusions and the mean degree of distress evoked by the intrusions were assessed during the following seven days. salivary cortisol and alpha-amylase were collected at seven time points prior to, and after the trauma film.

Eligibility criteria:
inclusion criteria: * healthy participants * german on a native level exclusion criteria: * former or present dsm iv axis i disorders * physical illnesses * any medication intake (except oral contraceptive) * history of sexual abuse or rape * pregnancy or lactation period
liquid biopsy for detection of driver mutation in nsclc

Conditions: Non Small Cell Lung Cancer

Summary: the purpose of this study is to evaluate the diagnostic and prognostic efficacy of liquid biopsy in different specimens and in different methods compared with tissue detection .

collect plasma and other specimens from patients who are newly diagnosed with nsclc or with drug-resistant and plan to receive gene detection to complete the diagnostic test for liquid biopsy .participants who come from diagnostic test and plan to receive tyrosine kinase inhibitors (tki) therapy will be collected plasma and other specimens every month during the regiments and monitor the changes of driver motion to predict the prognosis of targeted therapy.

Eligibility criteria:
cohort 1 inclusion criteria: * patients newly diagnosed with nsclc confirmed by tissue biopsy and going to receive the detection of gene mutation or patients have obtained drug-resistance after receiving molecular target therapy and plan to re-biopsy. * age ≥ 18 years * newly diagnosed patients have not received tki and chemotherapy * patients who are drug-resistant have not received next-generation tki exclusion criteria: * patients who have more than one type of carcinoma * patients who reject to sign the informed consent from cohort 2 inclusion criteria: * patients from cohort1 with sensitive driver mutation and plan to receive tki therapy * patients will have regular follow-up in chinese people liberation army general hospital every month. exclusion criteria: * patients who are refused to provide the informed consent from

Keywords: nsclc liquid biopsy driver mutation
the effect of preoperative intravenous fluid bolus on post-induction hypotension in elective cystoscopies.

Conditions: Postinduction Hypotension; Hypotension During Surgery

Summary: this study aims to determine whether a standardized, weight-based crystalloid fluid bolus administered preoperatively reduces the incidence of postinduction hypotension (pih) in patients undergoing cystoscopy.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old. 2. undergoing elective cystoscopy surgery as the primary procedure. 3. able to provide informed consent. exclusion criteria: 1. emergency surgeries. 2. past history of amputations of any body part. 3. allergies or contraindications to any medications used in the protocol or lactated ringers. 4. systolic heart failure with lvef \< 30% within the last year. 5. severely depressed rv function within the last year. 6. restrictive diastolic dysfunction within the last year. 7. currently pregnant.

Keywords: postinduction hypotension hypotension cystoscopy lactated ringers
sa versus soi surfaces for single implant-supported crown

Conditions: Dental Implant Failed; Bone Resorption

Summary: the purpose of this randomized controlled trial is to compare clinical data and implant stability of immediately loaded tsiii osstem implants with sandblasted and acid-etched (sa) surface versus implants with sa surface modified with ph buffering agent for the rehabilitation of single implant-supported crown.

this study aimed to evaluate if there are some benefits using novel implant surface. this surface should improve the secondary implant stability, reducing the overall time needed for the osseointegration. main benefits in clinical practice should be reduced treatment time.

Eligibility criteria:
inclusion criteria: * any partially edentulous subject requiring at least two single (preferable non-adjacent) implant-supported crowns, being at least 18 year old and able to sign an informed consent will be screened for eligibility. bone volumes should allow the placement of two implants at least 8.5 mm (maximum 10 mm) long and 4.5 mm (minimum 3.5 mm) wide, with a minimal insertion torque of 30 ncm. implants can be placed in previous post-extractive socket or in augmented bone, if at least 4 to 6 months have passed from the extraction or from augmentation procedures. exclusion criteria: * patients unable to commit to 5 years follow-up. * general contraindications to implant surgery. * less then 4 mm of keratinised gingiva crestally (at the implant sites). * immune-suppressed/compromised patients. * patients irradiated in the head and/or neck. * uncontrolled diabetes. * pregnancy or lactation. * untreated periodontal disease. * poor oral hygiene and motivation (full mouth bleeding and full mouth plaque index higher than 25%). * addiction to alcohol or drugs. * psychiatric problems and/or unrealistic expectations. * patients with an acute infection or suppuration in the site intended for implant placement. * patients needing any form of tissue augmentation at implant placement. * immediate post-extractive implants (implants can be placed after a 3-month healing period). * patients treated or under treatment with intravenous amino-bisphosphonates. * patients referred only for implant placement if the follow-up cannot be done at the treatment center. * patients participating in other studies, if the present protocol could not be fully adhered to.

Keywords: dental implants implant surfaces marginal bone loss
oral health and pregnancy

Conditions: Dental Caries; Pregnancy Related

Summary: the aim of this study is to identify the knowledge, behavior and social representation on dental health among pregnant women. this study could improve, in the future, prevention, treatments and care for them.

pregnant women will have to complete a questionnaire that brings together their knowledge, practices and social representations of oral health during their current pregnancy.

Eligibility criteria:
inclusion criteria: * pregnant t women over 18 years old * french language exclusion criteria: - pregnant women under 18 years old

Keywords: oral hygiene public health pregnancy prevention patients coming to the chu adv montpellier for consultation pregnant patients knowledge literacy