Kornimate/medical-research-clean huggingface dataset:
outcome and quality of life in obese patients underwent laparoscopic vs. open appendectomy

Conditions: Obesity; Appendicitis Acute

Summary: although obesity is a popular reason for choosing laparoscopic appendectomy (la) versus open appendectomy (oa), however, the question of whether there is a difference remains. the goal of the present study is to investigate if there is a difference between oa and la in obese patients. in the present study, fifty-eight obese patients were diagnosed with acute appendicitis according to alvarado score at the department of surgery at suez canal university hospitals from march 2020 till august 2021were included. the study participants were assigned to two groups, after their approval: la and oa. the investigators hypothesized that evaluating the outcome and quality of life of laparoscopic appendectomy for the obese patients would be a potential step for standardization of the laparoscopic approach for obese patients who are arranged for appendectomy.

although obesity is a popular reason for choosing laparoscopic appendectomy (la) versus open appendectomy (oa), however, the question of whether there is a difference remains. the investigators' goal is to investigate if there is a difference between oa and la in obese patients. fifty-eight obese patients were diagnosed with acute appendicitis according to alvarado score at the department of surgery at suez canal university hospitals from march 2020 till august 2021were included. the study participants were assigned to two groups, la and oa. this study aimed to compare la and oa regarding intraoperative complications, length of hospital stays, post-operative pain, and rate of postoperative complications. meanwhile, using the sf-36 scoring questionnaire, the quality of life was compared between both groups.

Eligibility criteria:
inclusion criteria: * patients aged between 18-40 years, with bmi ≥ 30 kg/m2 and diagnosed as acute appendicitis according to alvarado score i.e., history of right lower quadrant pain or peri-umbilical pain shifting to the right lower quadrant with nausea and/or vomiting, fever of more than 38ºc, right lower quadrant guarding, and tenderness on physical examination and/or leukocytosis above 10,000 cells per ml were included. exclusion criteria: * the investigators excluded patients with a bleeding tendency., previous lower abdominal surgery, abdominal tuberculosis, mass formation either clinically or by ultrasound, end-stage renal disease (esrd) patients, and patients who refused to participate in the study

Keywords: appendicitis obesity laparoscopic appendectomy
outcomes from a rct comparing preventive versus delayed ligation of dvc during robot-assisted radical prostatectomy

Conditions: Prostate Cancer

Summary: since its introduction, robot-assisted radical prostatectomy (rarp) have become the standard surgical approach for the treatment of prostate cancer in the united states and then in europe. continuous refinements of surgical technique has been described in order to maximise outcomes while minimizing morbidities. the management of dvc is a crucial steps during rarp. it could be done prior or after its transection thanks to haemostatic effects of the pneumoperitoneum. this topic has been already investigated by some authors. however, no high quality evidence is available to opt in favour of either of the two approaches. findings about estimated blood loss, positive surgical margins and urinary recovery differ among these studies and only one is a randomized controlled trial in a laparoscopic setting with a limited number of patients. therefore, our objective was to evaluate in a prospective randomised setting whether a delayed ligation of the dorsal vascular complex impacted on perioperative, functional and oncological outcomes as compared to preventive ligation during robot-assisted radical prostatectomy.


Eligibility criteria:
inclusion criteria: * male patients, aged 18-80 years * patients willing and able to provide written informed consent * voluntary partecipation * clinical indication to robot-assisted radical prostatectomy exclusion criteria: * coagulation impairment at the time of surgery * salvage radical prostatectomy
novellusdx cancer early detection blood test- clinical trial

Conditions: Lung Cancer

Summary: novellusdx early detection test is a simple to perform blood test, which identifies the deregulated signaling pathways within the patient tumor based on protein secretion to the blood, thus enabling early stage disease signature detection. the investigators' current clinical trial is focused on proving the main feature of novellusdx's early detection test- discriminating between cancer patients and healthy subjects.


Eligibility criteria:
inclusion criteria: * subjects ages 18 and above icf obtain exclusion criteria: * none

Keywords: lung cancer blood sample
determining icu staffs conceptions, opinions, views, experiences and reflection of brain death and organ donation

Conditions: Brain Death

Summary: the study aims to gather information regarding the individual perceptions, opinions, beliefs, and conceptual understanding of healthcare professionals working in the intensive care units at the university hospital basel and to determine associations of individual beliefs, personal, educational, and professional experiences with individual perceptions, opinions, and conceptual understanding regarding brain death and organ donation.

to achieve the study objectives, the investigator will employ a questionnaire-based survey administered to the consenting/participating nurses and physicians. the questionnaire will address various aspects related to personal background, religious affiliation, beliefs about life after death, the conceptual understanding of brain death and organ donation, as well as experiences and opinions related to these topics.

Eligibility criteria:
inclusion criteria: * consenting nurses and physicians currently working in the intensive care unit (icu) at the university hospital basel * only nurses and physicians consenting to participate will be included exclusion criteria: * nurses and physicians not currently working (any more) in the intensive care unit (icu) at the university hospital basel * nurses and physicians who do not consent

Keywords: organ donation intensive care unit
bicycle training on ventilatory functions in duchenne muscular dystrophy

Conditions: Duchenne Muscular Dystrophy

Summary: the purpose of the study is to investigate the effect of bicycle ergometry training on ventilatory functions in boys with duchenne muscular dystrophy.

duchenne muscular dystrophy (dmd) is a common genetic x chromosome-linked recessive muscular dystrophy. it causes deterioration in mobility, progressive deformities in musculoskeletal system, upper limb impairment, and impaired airway clearance. deterioration in respiratory muscles is the major cause of mortality and morbidity in dmd in their second to the third decade as a secondary complication in respiratory and cardiovascular systems. cycling exercise is an easy functional treatment that considered as an aerobic exercise used to improve ventilatory functions, strength of respiratory muscles and therefore prevents respiratory diseases. several studies support the benefit of bicycle ergometry training on ventilatory functions in different diseases while, there is no research conducted its effect on duchenne muscular dystrophy. hence, there is need to study the effect of bicycle ergometry training on ventilatory functions in duchenne muscular dystrophy. thirty boys with duchenne muscular dystrophy aged from 8-10 years will be recruited from abu el-rish pediatric hospital. they will be divided randomly into control group (15 boys) and study group (15 boys). control group will be participated in designed physical therapy program. study group will be trained on the bicycle ergometer in addition to the same designed physical therapy program participated in control group.

Eligibility criteria:
inclusion criteria: 1. boys ages will be ranged from 8 to 10 years old. 2. confirmed diagnosis as duchenne muscular dystrophy. 3. lower limb functional levels ranged from grades 1 through 3 acc. to vignos scale for lower extremities. 4. still ambulant and able to sit independently for at least 1 hour. exclusion criteria: 1. ccongenital or acquired skeletal deformities or cardiopulmonary dysfunction. 2. previous orthopaedic surgery in lower limbs. 3. behavioral problems causing inability to cooperate during the study.

Keywords: bicycle erogmeter spirometry duchenne muscular dystrophy
safety, efficacy, and acceptability study of an eye drop formulation in subjects with dry eye disease

Conditions: Dry Eye Syndromes

Summary: this study will evaluate the safety, efficacy, and acceptability of an eye drop formulation in subjects with dry eye disease.


Eligibility criteria:
inclusion criteria: * dry eyes * current use of eye drops for dry eye at least twice daily, on average for at least 3 months exclusion criteria: * cataract, laser-assisted in situ keratomileusis (lasik), or photorefractive keratectomy (prk) surgery in the last 12 months * need to wear contact lenses during the study, or has worn contact lenses in the last 6 months * active ocular allergy
post-covid-19 sequelae: osteonecrosis of femoral head

Conditions: Osteonecrosis

Summary: during the most recent pandemy covid-19, various advises concerning complications following high corticosteroid doses administration were pubblished in 2020. however, evidence is lacking about the incidence of non-traumatic osteonecrosis of the femoral head (onfh) in patients experiencing covid-19. the aim of the present proposal is to obtain a quantitative estimation of onfh cases among patients previoulsy hospitalized and treated for covid-19 at asst-papa giovanni xxiii.

non-traumatic osteonecrosis of the femoral head (onfh) is usually asimptomatic, but in advanced stages involves disabilities, leading to the lost of the joint functions. the classification of the osteonecrosis type is based on clinical and radiographical criteria. among these, the magnetic resonance (rm) plays a crucial role for detecting lesions in the early asymptomatic phase. an high incidence of onfh has been described during the sars-1 pandemy: it was observed that 40% of males younger than 60, under treatment with corticosteroids, experienced it. based on these evidences and avises concerning complications caused by intensive corticosteroid therapy during 2020, the investigators have hypothesized that the onfh could be underestimated in patients affected by covid-19 and that it would be diagnosed only in its advanced disabling phase. therefore, the main aim of this investigation is to obtain an early estimation of cases experiencing onfh through rm as long-term sequela of covid-19, including the assessment of articular sites involved. this will be evaluated in patients hospitalized and treated for covid-19 at asst-papa giovanni xxiii between february 23, 2020 and may 21, 2020. after enrollment one visit and an instrumental assessment of hip status, including an rm and a radiography, will be scheduled in order to detect lesions at least at 1 year from previous hospitalization.

Eligibility criteria:
inclusion criteria: * male * age \> 18 and \< 60 years old * hospitalization between 23-feb-2020 and 21-may-2020 because of covid-19 diagnosis * hospitalization duration \> 25 days * treatment with steroid drugs during hospitalization (total cumulative dose \> 2 g) * signature of written informed consent exclusion criteria: * presence of any implantable medical device defined as 'unsafe' for rm (eg. cardiac pacemaker; vascular stent and gastrointestinal clips evaluated as 'unsafe') * previous experience with episodes and symptoms associated with claustrophobia.

Keywords: femoral osteonecrosis corticosteroids covid-19
correlating ic/pbs symptoms with urine biomarkers

Conditions: Interstitial Cystitis; Pelvic Pain

Summary: completion of a brief survey tool and providing an urine specimen. the study purpose is to improve our understanding of interstitial cystitis and painful pelvic syndrome.

the purpose of the study is to improve our understanding of the ic/pbs and develop new treatments. participation in the study will allow us to compare clinical information, obtained by completion of a brief survey, with substances found in the a urine specimen that is donated to the beaumont biobank.

Eligibility criteria:
inclusion: 1. men and women with interstitial cystitis/painful bladder syndrome greater than 18 years old 2. male and female controls without a history of ic/pbs diagnosis exclusion: 1. unable to complete questionnaires and/or give informed consent

Keywords: interstitial cystitis pelvic pain
dynamic decompressive craniotomy

Conditions: Brain Edema; TBI (Traumatic Brain Injury); Stroke, Acute; Cerebral Hemorrhage; Brain Tumor

Summary: prospective observational study on patients undergoing decompressive craniotomy

a prospective study of 20 neurosurgical patients evaluating the dynamic decompressive craniotomy technique using neurovention, llc craniotomy bone flap fixation plates. the plates allow for rigid and semi-rigid bone flap fixation dependent on the implantation technique. a dynamic craniotomy involves bone flap fixation wherein a limited transient outward bone flap movement is allowed by the plates to compensate for an increase in intracranial pressure from brain swelling. the plates also prevent the craniotomy bone flap from sinking inside the skull and compressing on the brain. cerebral decompression surgery is undertaken for patients with cerebral swelling from malignant strokes, medically intractable intracranial pressure elevation in traumatic brain injuries and brain tumors. the dynamic craniotomy technique eliminates or reduces the need for a cranioplasty surgery with a potentially significant improvement in outcome.

Eligibility criteria:
inclusion criteria: * patients undergoing craniotomy who are at an increased risk for developing post- operative brain swelling or increased intracranial pressure from a malignant stroke * patients undergoing craniotomy who are at an increased risk for developing post- operative brain swelling or increased intracranial pressure from traumatic brain injury * patients undergoing craniotomy who are at an increased risk for developing post- operative brain swelling or increased intracranial pressure from brain tumors. exclusion criteria: * patients with blown pupil (cerebral herniation), * massive brain swelling * dismal outcome not expected to survive more than 1-2 weeks.

Keywords: decompressive craniotomy dynamic craniotomy craniectomy cranial fixation plate cerebral swelling intracranial hypertension cranioplasty
exercise or relaxation for smoking cessation

Conditions: Nicotine Dependence; Smoking Cessation

Summary: this research study is being done to find out if adding a moderate exercise program or a relaxation program to a smoking cessation treatment program will improve smoking cessation and health in postmenopausal women. we hope to learn which group is more successful at quitting, has less symptoms of withdrawal from smoking and has improved health.

prevalence of smoking among women has declined more slowly in women than among men. women who quit smoking substantially reduce the risk of premature death. a multi-modal approach to smoking cessation with combined behavioral and pharmacological interventions generally yields the highest success rates. the majority of subjects who are able to achieve abstinence return to smoking. smoking relapse rates are 50-80% within one year with the majority of smokers relapsing within the first 3 months. interventions are needed to both enhance smoking cessation rates and prevent relapse rates in order to substantially impact long-term quit rates.we intend to compare the effectiveness of a smoking cessation program combined with a moderate exercise program to an identical smoking cessation program combined with a relaxation-meditation control condition. in a substudy, we will also evaluate the effectiveness of the intervention in premenopausal women (n=40)

Eligibility criteria:
inclusion criteria: * postmenopausal women at least 45 years of age * smoking at least 10 cigarettes per day * motivated to quit smoking * ambulatory * currently exercising for 90 minutes of moderate exercise or less per week * motivated to exercise * permission from primary care provider * good general health exclusion criteria: * denied medical clearance from primary care provider * unstable angina or uncompensated heart failure * systolic blood pressure greater than 165 or diastolic blood pressure greater than 100 * heart attack or stroke within the preceding 6 months * hip fracture within the preceding 6 months * unstable medical or psychiatric disorder (e.g., current major depressive disorder or substance abuse or dependence) * exercise-exacerbated neuromuscular disorder * treatment for depression within the last year * estimated creatinine clearance of less than 30cc/minute * current use of a smoking cessation aid (i.e., bupropion, nrt, clonidine) * current use of psychotropic medication for a psychiatric problem * prescription narcotic abuse or dependence with the exception of people that have been stabilized on methadone maintenance or suboxone * previous serious adverse event with chantix use

Keywords: smoking cessation exercise postmenopausal women chantix varenicline
ambulation versus standing on postoperative day 0

Conditions: Osteoarthritis

Summary: the purpose of this study is to determine the impact of the timing of physical therapy (pt) initiation on postoperative length of stay and the time to physical therapy clearance following total knee replacement.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * scheduled for primary tka (total knee arthroplasty) for any degenerative condition * anesthesia for tka is spinal + regional block (adductor canal block) exclusion criteria: * require assistive devices (walker, wheelchair) for ambulation preoperatively * planning to go to a subacute nursing facility or acute rehab facility following surgery * \< 18 yrs of age * not willing to participate or unable to consent

Keywords: degenerative joint disease total knee arthroplasty physical therapy arthroplasty, replacement, knee
n-3 fatty acids as the first-line antidepressant therapy: from biomarkers to clinical subtypes

Conditions: Major Depressive Disorder

Summary: investigate the clinical subtypes and the biological markers to personalize the use n-3 pufas (epa, dha, and epa/dha) in mdd.

in this proposal, the investigators aim to explore the clinical subtypes and biological markers to personalize the use n-3 pufas (epa, dha, and epa/dha) in mdd. by stratifying the subjects with (versus without) remission and treatment response, the biological markers are expected to have important prediction effects in future clinical practice.

Eligibility criteria:
inclusion criteria: * the diagnostic criteria of dsm-iv for mdd * 18 to 65 years old * pre-study ratings of 18 or greater on the 21-item hamilton rating scale for depression (hamd) * physically healthy under comprehensive evaluations in medical history, physical examination, and laboratory parameters tests * have not received any psychiatric treatment in 2 weeks * competent to receive a full explanation of this study and give written informed consent. exclusion criteria: * a recent or past history of other dsm-iv axisi diagnoses besides unipolar major depression, including psychotic disorders, organic mental disorders, impulse control disorders, substance use disorder or substance abuse (last 6 months prior to the study), and bipolar disorders * axisii diagnoses, including borderline and antisocial personality disorder * a notable medical comorbidity * acutely suicidal ideation and attempt were noted that close monitoring such as hospitalization is necessary * regular consumption of omega-3 pufas supplements or a habit of eating ﬁsh equal or more than 4 times per week

Keywords: depression, omega-3 fatty acids, nutritional intervention
evaluate the efficacy and safety of peg-rhg-csf in preventing neutropenia after chemotherapy in patients with non-hodgkin's lymphoma

Conditions: Non Hodgkin's Lymphoma

Summary: the main treatments for non-hodgkin's lymphoma are surgery, radiotherapy, chemotherapy, and bone marrow transplantation. neutropenia is the most common and serious complication of most chemotherapy. this study is a multi-center, open-label, single-arm clinical study to evaluate the efficacy and safety of jinyouli in preventing neutropenia in patients with non hodgkin's lymphoma after chemotherapy.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years, gender is not limited; 2. patients with lymphoma diagnosed by histopathology or cytology; 3. patients requiring multi-cycle chemotherapy; 4. planned chemotherapy regimen fn risk ≥ 20 % , or 10% \<fn risk \< 20% with high risk factors ; according to the judgment of the investigator, there is a risk of fn occurrence if g-csf support is not accepted, peg-rhg-csf should be used prophylactically from the first cycle; 5. physical status (kps) score ≥ 70 points; 6. expected survival period of more than 3 months; 7. normal bone marrow hematopoietic function (anc ≥1.5×10\^9/l, plt≥80×10\^9/l, hb≥75g/l, wbc≥3.0×10\^9/l); 8. alanine aminotransferase (alt) and aspartate aminotransferase (ast)≤2.5 times the upper limit of normal value, or≤5 times the upper limit of normal value when there is liver metastasis; total bilirubin (tbil)≤2.5 times the upper limit of normal value; serum creatinine (cr)≤2 times the upper limit of normal value; 9. female patients of childbearing age must be negative in urine pregnancy test before treatment; 10. the testers (or their legal representatives/guardians) must sign an informed consent form. exclusion criteria: 1. lymphoma central involvement; 2. hematopoietic stem cell transplantation or organ transplantation; 3. local or systemic infection without adequate control; 4. severe internal organ dysfunction and occurred in the last 6 months myocardial infarction; 5. those who used other test drugs of the same kind or accepted other clinical trials within 4 weeks before enrollmen； 6. allergy to peg-rhg-csf, rhg-csf and other preparations or proteins expressed by escherichia coli; 7. severe mental illness, affecting informed consent and/or adverse reaction expression or observation; 8. pregnant or lactating female patients; women who refuse to accept contraceptive measures ; 9. researchers determine unsuited to participate in this trial.