Kornimate/medical-research-clean huggingface dataset:
vital start: brief facility-based video intervention

Conditions: HIV/AIDS

Summary: this a multi-center, parallel group, randomized controlled outcome assessor blinded trial with a qualitative descriptive component that seeks to assess the effectiveness of a brief facility-based video intervention to optimize retention and adherence to art among pregnant and breastfeeding women with hiv infection.

universal hiv testing and treatment can accelerate population-level art initiation and is critical to realize the unaids 90-90-90 goals. malawi pioneered option b+ (b+), a novel application of test-and-treat that provided life-long art for hiv+ pregnant and breastfeeding women. while maternal art uptake improved 7-fold, retention and adherence remained suboptimal: only 59% were retained after two years, and of these, only two-thirds achieved adequate art adherence. other b+ countries are observing suboptimal retention. vital start (video-intervention to inspire treatment adherence for life) is a brief facility-based video intervention, created with formative participatory research, applied theoretical frameworks, and evidence-based message framing techniques. vital start was designed to help optimize retention and adherence to art among pregnant and breastfeeding women in malawi. the study will evaluate the impact, implementation and cost effectiveness of vital start in a multisite randomized controlled trial (rct) in malawi with the primary composite outcome of retention and adherence (viral suppression) 12 months after starting antiretroviral therapy (art). the study will also examine the delivery of vital start via surveys and interviews with patients and partners and conduct cost-effectiveness analyses. if successful, vital start will provide an intervention that (1) standardizes and improves counseling at a critical teaching moment through an engaging and culturally sensitive experience, (2) is inexpensive and rapidly scalable without decelerating art expansion, and (3) allows more efficient use of health care worker time.

Eligibility criteria:
inclusion criteria: * women who are hiv positive by two antibody rapid tests approved by the malawi ministry of health * women age ≥18 years or 16-17 years if married or have a child * women who understand chichewa * women who are willing to provide informed consent * women who intend to remain in the health center catchment area for at least 6 months exclusion criteria: * women already on art * women with significant pre-existing psychiatric comorbidity at enrollment that may impact ability to provide consent according to the clinical judgment of study personnel (including cognitive impairment or known psychotic disorder) * women who participated in the study pilot

Keywords: pregnant women viral suppression retention video intervention pre-art counseling hiv adherence pmtct
identification of new predisposition genes in differentiated thyroid cancer

Conditions: Differentiated Thyroid Cancer; Thyroid Cancer, Nonmedullary

Summary: the purpose of this research is to find new predisposition genes for differentiated thyroid cancer (dtc).

the purpose of this research is to find new predisposition genes for differentiated thyroid cancer (dtc). therefore, in the absence of a bap1 and dicer1 abnormality, we offer to sequence your whole genome (wgs) or partial genome (genotyping) for a previously unknown genetic abnormality. furthermore, the discovery of new genes would be a major medical advance that could contribute to the identification of new therapeutic targets. this research will be conducted at the university hospital of nantes and the hospital of vendée and 95 people should participate.

Eligibility criteria:
inclusion criteria: * probant subjects * minor or adult subject * adult subject or legal guardian for minor subjects agreeing to sign the study consent and biospecimen consent * subject with differentiated thyroid cancer without an identified causative mutation in the bap1 and dicer 1 predisposition genes * patient affiliated to a valid social security plan relative subjects * adult subjects * subject agreeing to sign the study consent and the biocollection consent * subject with differentiated thyroid cancer or from a family with several cases of differentiated thyroid cancer without a causal mutation identified in the bap1 and dicer 1 predisposition genes * patient affiliated to a social security plan exclusion criteria: * subject refusing to participate * subjects with a causal mutation identified in the predisposition genes: bap1 and dicer 1 * subjects under guardianship, curatorship or safeguard of justice or not socially insured * subjects with another syndromic predisposition to thyroid cancer (cowden, werner, paf)
evaluation of cova™+ card in adult cardiac surgery

Conditions: Safety; Tolerance

Summary: the aim of this observational study is to evaluate the safety of the guided healing and adhesion prevention membrane, cova™+ card, in adult cardiac surgery. the causality of the collagen membrane according to the occurrence of peri and post-operative complications will be evaluated.

assessment of the safety of cova™+ card, collagen membrane to prevent adhesion appearance, in cardiac surgery in adult patients: * collection of post-operative complications, causality of the membrane * collection of complications in the 3-month period after the surgery, causality of the membrane * collection of peri-operative complications, causality of the membrane * collection of complications, 3 months after the surgery * assessment of the efficacy of cova™+ card if re-operation * assessment of the surgeon's satisfaction

Eligibility criteria:
inclusion criteria: * 18 years of age or older * cardiac surgery using cova™+ card exclusion criteria: * in accordance with the instruction for use (ifu) of the medical device. * refusal of participation to the study

Keywords: collagen membrane cardiac surgery postoperative complication
feasibility of appropriate smartphone position during video-assisted cardiopulmonary resuscitation

Conditions: Cardiac Arrest (CA)

Summary: there is a gap in our knowledge regarding whether video-assisted cardiopulmonary resuscitation (v-cpr) is feasible when a lay responder is alone at the scene. the feasibility of v-cpr was measured in a simulated cardiac arrest scenario when a lay responder was alone with the patient.

there is a gap in our knowledge regarding whether video-assisted cardiopulmonary resuscitation (v-cpr) is feasible when a lay responder is alone. the feasibility of v-cpr was measured in a simulated cardiac arrest scenario when a lay responder was alone with the patient. a pilot study was conducted to measure the appropriate smartphone position and placement time when a lay responder is alone. two simulated cardiac arrest locations were prepared: a living room and yard. the performance of the participants were recorded. after that, the quality and assessability of the videos were evaluated by five experts (experienced in cpr teaching and evaluation).

Eligibility criteria:
inclusion criteria: * layperson or health care professional, who is phisically and mentally able to do a simulated cpr scenario (participants in the scenario) * expert in cpr training (assessors) exclusion criteria: * technical issue during data collection

Keywords: video-assisted cardiopulmonary resuscitation cardiac arrest cardiopulmonary resuscitation lay responder
effect of a lipidic and proteic controlled diet on parkinson's disease

Conditions: Parkinson Disease

Summary: parkinson's disease concerns some defects in carbohydrates metabolism involved in the progress of the pathology. ketogenic diet has been largely studied as treatment on drug-resistant epilepsy and other neurologic diseases, but there is little information on the impact of this kind of diet in clinical aspects of parkinson's disease. the aim of our study is thus to evaluate the effect of a lipid and protein controlled diet on resting energy expenditure, body composition and symptoms in patients with parkinson's disease.

parkinson's disease concerns some defects in carbohydrates metabolism involved in the progress of the pathology. ketogenic diet has been largely studied as treatment on drug-resistant epilepsy and other neurologic diseases, but there is little information on the impact of this kind of diet in clinical aspects of parkinson's disease. the aim of our study is thus to evaluate the effect of a lipid and protein controlled diet on resting energy expenditure, body composition and symptoms in parkinson's disease patients.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of parkinson's disease, treated with l-dopa or other dopaminergic drugs. * mini mental state examination (mmse) \>24. * activities of daily living \>3. exclusion criteria: * mini nutritional assessment \<17; bmi \<18, hypoalbuminemia or lymphopenia. * acute or chronic liver diseases; * renal function impairment (clearance creatinine \<30ml/min); * cancer; * acute inflammatory diseases; * thyroid diseases; * diabetes mellitus; * dysphagia; * dementia; * dyslipidemia; * history of recent cardiovascular or cerebrovascular events; * psychiatric diseases; * iatrogen parkinsonism.
rollover study in participants with metastatic solid tumors benefiting from therapy with sacituzumab govitecan-hziy

Conditions: Metastatic Solid Tumor

Summary: the goal of this clinical study is to learn more about the study drug, sacituzumab govitecan-hziy, and how safe it is in participants with metastatic cancer (cancer that has spread).

this is a rollover study. only participants who continue to receive clinical benefit from continuation of sacituzumab govitecan-hziy therapy and are tolerating therapy at the time of enrollment are eligible for this study. participants enrolled may continue to receive sacituzumab govitecan-hziy at the dose that they were receiving in the gilead parent study at the time of consenting to participate in this rollover study.

Eligibility criteria:
key inclusion criteria: * receiving ongoing treatment with sacituzumab govitecan in a gilead (previously immunomedics)-sponsored parent study * continuing to receive clinical benefit from sacituzumab govitecan-hziy therapy key exclusion criteria: * females who are pregnant or lactating * initiated therapy with another cancer therapeutic agent since receiving last dose of study drug on the parent study in which they participated * experienced a toxicity from sacituzumab govitecan-hziy that resulted in permanent discontinuation of therapy * have other concurrent medical or psychiatric conditions that, in the investigator's opinion, may be likely to confound study interpretation or prevent completion of study procedures and follow-up examinations. note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: adc antibody-drug conjugate trop-2 sn-38
low or high dose of dexamethasone in patients with respiratory failure by covid-19

Conditions: Covid19; Corticosteroids

Summary: after recovery trial publication, low dose (6 mg dexamethasone for 10 days) was recommended as the usual care treatment in hospitalized patients with respiratory failure by covid-19 needing oxygen therapy. recovery trial showed how the use of dexamethasone 6 mg / day for ten days compared to standard treatment without the use of corticosteroids in hospitalized patients reduced mortality at 28 days (22.9% with dexamethasone vs 25.7% without dexamethasone). in the dexamethasone group, the incidence of mortality was lower than standard treatment in patients with hypoxia and the need for mechanical ventilation (29.3% with dexamethasone vs 41.4% without dexamethasone), in patients admitted to the hospital ward with a need for oxygen therapy (23.3% with dexamethasone vs 26.2% without dexamethasone), but they did not find differences between those admitted patients who did not need oxygen therapy. there are two other studies (dexa-covid-19 and codex) where they observed benefits of the use of dexamethasone 20 mg / day 5 days, and 10 mg / day 5 days (total 10 days) in patients admitted for respiratory distress syndrome (ards) and covid-19. at present, it is unclear what dose of dexamethasone is most beneficial in patients with covid-19 and respiratory failure.

objective: the investigators aim to assess the efficacy of high dose of dexamethasone (20 mg / day 5 days, and 10 mg/day 5 days) versus low dose of dexamethasone (6 mg/day 10 days) in patients with respiratory failure by covid-19.

Eligibility criteria:
inclusion criteria: * age 18 years or older. * hospitalized covid-19 patients admitted to the hospital. * patients requiring supplemental oxygen. level 4 using the world health organization 7-point ordinal scale for clinical improvement * patients requiring corticosteroids (dexamethasone) according to hospital protocol. exclusion criteria: * pregnancy or active lactation. * patient is expected to die in the next 48 hours. * known history of dexamethasone allergy or known contraindication to the use of corticosteroids. * daily use of corticosteroids in the past 15 days. * indication for corticosteroids use for other clinical conditions (e.g. refractory septic shock). * consent refusal for participating in the trial. * different level of 4 in level 4 using the world health organization 7-point ordinal scale for clinical improvement.

Keywords: covid19 respiratory failure corticosteroids
three good things 2020: a brief text-based wellness intervention

Conditions: Job Related Stress

Summary: this trial will be open to all michigan medicine department of family medicine faculty, resident, or staff. the intervention will consist of asking participants the "3 good things" based on positive psychology theory. participants will be asked to list three things that went well that day and to consider their role in these outcomes. pre and post surveys will be completed to evaluate this intervention. at the end of the trial the study team will also select a limited number of entries from participants to share some of the "good things" which people listed. these will be edited to ensure writer anonymity and participants will be informed of this plan in the study introduction.


Eligibility criteria:
inclusion criteria: * faculty, resident, or staff in the michigan medicine (mm) department of family medicine exclusion criteria: * not a member of family medicine at mm

Keywords: satisfaction depression
a comparison of topical nepafenac to placebo in corneal epithelial healing times and postoperative pain relief

Conditions: Photorefractive Keratectomy

Summary: the purpose of this study is to compare healing times and subjective pain level responses of nepafenac to placebo after photo refractive keratomileusis (prk) surgery.


Eligibility criteria:
inclusion criteria: * 19 years or older with healthy ocular status and pre-operative refractive anisometropia of less than 2.000 diopters between eyes undergoing bilateral prk surgery. * other protocol-defined inclusion criteria may apply. exclusion criteria: * those desiring prk in only one eye, those in need of additional topical eye medications, those with history of drug/alcohol abuse, women breastfeeding or pregnant. * other protocol-defined exclusion criteria may apply.

Keywords: photorefractive keratectomy
urine hpv testing for cervical cancer screening among women living with hiv in south africa

Conditions: Cervical Cancer; CIN2; CIN3

Summary: the purpose of this study explores the usefulness of urine samples for cervical cancer screening in human immunodeficiency virus (hiv)-infected women. cervical cancer occurs when women are infected with the human papillomavirus (hpv), which can cause changes in the cells that lead to cervical precancer and, eventually, cervical cancer if untreated. however, urine hpv testing has not been well validated low- and middle-income country settings, with no data available to guide its use in hiv-infected women.

invasive cervical cancer is a significant health burden in low and middle income countries. hiv-infected women in africa are particularly affected and have an estimated invasive cervical cancer risk \~20-fold higher than women without hiv. previous studies have been performed among only hiv-uninfected women or those whose hiv status was unknown. additionally, hiv infected women are often diagnosed with invasive cervical cancer at younger ages. cervical cancer is preventable by regular screenings which includes doing a pap smear or hpv tests. there is also treatment of precancerous cervical lesions and vaccination against high risk types of hpv. world health organization currently recommends high risk hpv testing for cervical cancer screening in both high and low resources settings. national guidelines in many low and middle income countries, including south africa, have been updated to include plans to transition from cytology or visual screening to primary hpv screening. urine hpv testing could provide a simpler approach for cervical screening that is more easily scaled in low and middle income countries. the study hypothesizes that high-risk human papillomavirus (hrhpv) testing on urine specimens will be similar in sensitivity and specificity for the detection of cervical intra-epithelial neoplasia grade 2 or worse (cin2+) compared to self- or clinician-collected sampling. this study will investigate whether women can collect their own samples for hpv testing using either urine or a small brush in the vagina. the results of hpv tests on urine, self-collected vaginal samples, and provider-collected cervical samples will be compared to see which sample type works best.

Eligibility criteria:
inclusion criteria: in order to participate in this study a subject must meet all of the eligibility criteria outlined below. 1. confirmed hiv-1 infection 2. age 25 years and older. 3. be willing and able to provide written informed consent. exclusion criteria: 1. pregnant or intend to become pregnant within 90 days of enrollment 2. have been screened for cervical cancer within the preceding year (365 days) 3. have an active sexually transmitted infection (sti; women may participate once treated) 4. have a surgically absent cervix 5. have a history of cervical cancer 6. have been vaccinated against hpv.

Keywords: cervical cancer hpv urine test hiv
allogenic cord blood transfusion in patients with cerebral palsy

Conditions: Cerebral Palsy

Summary: cerebral palsy is a disorder of movement and posture resulted from a non-progressive lesion or injury of the immature brain. it is a leading cause of childhood onset disability. many experimental animal studies have revealed that umbilical cord blood is useful to repair neurological injury in brain. on the basis of many experimental studies, umbilical cord blood is suggested as a potential therapy for cerebral palsy.

cerebral palsy (cp) is a group of neurodevelopmental conditions with abnormal movement and posture resulted from a non-progressive cerebral disturbance. it is the most common cause of motor disability in childhood. most therapies are palliative rather than restorative. umbilical cord blood (ucb) may be used as restorative approach for children with cp. many experimental animal studies have revealed that ucb is beneficial to improve and repair neurological injuries, this effect achieved due to immune regulation and angiogenesis as well as the neuroprotective effect. based on animal studies and some clinical trials, ucb is suggested as a potential therapy for children with cp. this study is prospective, non randomized (open label) with control group.

Eligibility criteria:
inclusion criteria: - confirmed diagnosis: cerebral palsy. exclusion criteria: * the presence of the following diseases in history: heart failure in the stage of decompensation, stroke in history less than 1 year ago, blood diseases; * decompensation of chronic and endocrinological diseases; * acute respiratory viral and bacterial infections, period less than 1 month after the acute phase. * hiv infection, hepatitis b and c. * oncological diseases, chemotherapy in the anamnesis; * tuberculosis.

Keywords: cerebral palsy cp cord blood stem cells
intra-articular pulsed radiofrequency neuromodulation versus intra-articular steroids for painful knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: to compare the efficacy of intra-articular pulsed radiofrequency to intra-articular steroids in patients with moderate-severe painful osteoarthritis of the knee.

patients adult patients with intractable knee pain for more than 6 months and radiographic evidence of grade ii, iii or iv knee osteoarthritis. must not have had a knee injection or other interventional procedure for knee pain within the past 12 weeks. must be on stable medications for the past 12 weeks and willing to keep medications stable for the first 12 weeks of the study. study design pilot study will enroll 30 patients randomized 1:1:1. 1. active control - intra-articular 4 milliliters 0.5% bupivacaine + 10mg dexamethasone + sham pulsed radiofrequency 2. placebo control - intra-articular 5 milliliters 0.9% saline + sham pulsed radiofrequency 3. treatment group - intra-articular 5 milliliters 0.5% bupivacaine + pulsed radiofrequency methods two 18-gauge radiofrequency needle with 10 millimeter active tip will be placed intra-articularly from an anterolateral and anteromedial approach to target the medial and lateral compartments. once satisfactory fluoroscopic placement is noted, the pulsed radiofrequency or sham-pulsed radiofrequency treatment will be administered. subsequently, the injectate will be administered. dexamethasone is selected as the corticosteroid as it is colorless and will be indistinguishable from the saline used in the intra-articular pulsed radiofrequency and placebo groups.

Eligibility criteria:
inclusion criteria: * capable of giving written informed consent * patients aged 18 years or older * patients with unilateral or bilateral knee pain for at least 3 months * radiographic evidence of knee osteoarthritis * appropriate candidate for steroid injection as determined by the investigator exclusion criteria: * chronic knee pain caused by infection, inflammation, tumors, and fractures * a history of acute knee pain, previous knee surgery, connective tissue diseases, progressive neurologic disease or uncontrolled psychiatric disorders * the administration of steroids or hyaluronic acids within the last three months * coagulation disorders * local infection at the site of intervention planned * active litigation related to this pain complaint
italian register for the study of complicated intra-abdominal infections

Conditions: Complicated Intra-abdominal Infections

Summary: the study will identify the epidemiological and treatment profiles of acute peritonitis in italy

the primary objectives of the study are: (1) the identification of specific risk factors for in-hospital mortality, in order to perfect the clinical management of patients with complicated intra-abdominal infections (ciais); (2) the identification of specific risk factors for multi-drug resistant organisms (mdros) isolation in patients with ciais, in order to improve the adequacy of empirical antimicrobial therapy. the secondary objectives are: (1) the description of the clinical, diagnostic and treatment profiles of patients with ciais in italian surgical departments; (2) the analysis of epidemiology and patterns of antimicrobial susceptibility of the microorganisms isolated in samples in intra-operative samples of peritoneal fluid or purulent exudate/discrete abscesses in patients with ciais; (3) the identification of specific risk factors for post-operative complications in patients with ciais.

Eligibility criteria:
inclusion criteria: all consecutively hospitalized adult patients (older than 18 years of age) undergoing surgery, interventional drainage or conservative treatment, with diagnosis of ciais (defined as abdominal infections originating in an organ cavity, extending into the peritoneal space, and forming an abscess or peritonitis) exclusion criteria: patients younger than 16 years-old, patients with pancreatitis or primary peritonitis