Kornimate/medical-research-clean huggingface dataset:
patient navigation and tailored treatment planning in latina patients with breast cancer

Conditions: Breast Carcinoma

Summary: this research trial studies how well patient navigation and tailored treatment planning work in latina patients with breast cancer. patient navigation and tailored treatment planning may provide extra support by guiding patients through the healthcare system, remove barriers to care and provide ease of access to essential resources, encourage patient participation in their care, provide in-language summaries and plans for follow-up care, improve patient access to needed supportive care services and may improve general healthcare experience in latina patients with breast cancer.

primary objectives: i. successful navigation of patients being screened or treated for breast cancer through the continuum of their care (from visit to visit; from surgical care to radiologic care to oncologic care; from oncologic care to supportive care; etc). ii. supply individualized in-language treatment summaries and follow-up care plans to enrolled patients. iii. supply tailored in-language survivorship plan summaries to enrolled patients. outline: patients receive treatment summaries and plan report that captures patient data through the use of an "intake checklist" completed during the initial consultation with the breast oncology team and used to guide referrals to existing services and programmed with generic information related to disease and treatment management plan. additional elements, such as psycho-social services, exercise, and/or nutrition, identified by the patient self-report, will be incorporated. patients also complete 3 questionnaires at each clinic visit. after completion of study, patients are followed up at 6 months or 12 months.

Eligibility criteria:
inclusion criteria: * patients receiving ongoing care at lac+usc * self-identified as latina (or hispanic) * known or suspected breast cancer * being seen in a breast cancer high risk, screening or prevention program or clinic or in one of the breast cancer clinics (surgical or medical oncology) exclusion criteria: * inability to sign informed consent or complete questionnaires and forms * self-identified as non-latina (or non-hispanic)

Keywords: sign or symptom
dose parameters for photodynamic therapy on periodontal disease

Conditions: Chronic Periodontitis

Summary: due to the phenomenon of bacterial resistance, photodynamic therapy (pdt) has been studied as an alternative to the use of antibiotics on the periodontal treatment. however, the studies show several discrepancies between the parameters adopted for pdt, which makes it difficult to compare the results and measure their efficacy. the objective of this research was to investigate the tissue dosimetric parameters used in pdt for the treatment of periodontal disease. in order to achieve this objective, the scattering pattern of light in periodontal tissue, the concentration of methylene blue in the periodontal pockets and the number of viable microorganisms were evaluated. this clinical trial included 30 patients with chronic periodontitis according to the eligibility criteria. the patients were in periodontal treatment at the dental clinic at the university of nove de julho, where the research was carried out. three incisors from each patient were selected for the experimental procedures. the pattern of light scattering was observed through intraoral photographs. a laser with emission of radiation with wavelength of 660 nm and 100 mw of power was used. the concentration of the photosensitizer (ps) in the periodontal pockets was evaluated by spectrometer before irradiation. methylene blue was used as ps at the concentration of 100 μm in two different formulation and vehicles to evaluate the drug dimerization. then, the procedures of irradiation of the pdt were carried out, with 3 irradiation times of 1, 3 and 5 min. the microbiological evaluation was performed from subgengival biofilms of the periodontal pockets of the experimental sites, before and immediately after the irradiation procedures.


Eligibility criteria:
inclusion criteria: * patient with chronic periodontitis; * the patient should have at least 15 teeth present, with a minimum of 3 incisors with depth of probing greater than 4 mm; * the patient should be in periodontal treatment at the dental clinic of the university of nove de julho, where this research was carried out. all patients were treated according to the protocol recommended by the american academy of periodontology; * minimum age of 18 years. exclusion criteria: * current smokers or regular smoking 12 months prior to enrollment; * patients with anemia, * patients with active cancer; * pregnant; * history of antibiotic therapy in the previous six months; * history of anti-inflammatory therapy in the previous three months; * patients with clotting disorders; * patients currently undergoing orthodontic treatment.

Keywords: photodynamic therapy periodontal disease dosimetry methylene blue
weight cycle post intervention

Conditions: Weight Gain

Summary: the aim of this follow-up (fu) study is to examine trajectory of body weight impacted by self-reported diet patterns and physical activities in 6 months at 3 monthly intervals from treatment cessation among patients who completed a pharmacotherapy trial. in addition, patient self-reported diet patterns and physical activities at respective time points will be described.

this is a real-world prospective observational study with primary data collection. all participants with a background be recommended to adopt lifestyle intervention as chronic weight management in china clinical practice. this fu study will enroll patients who completed surmount-cn trials, with planed study duration of 6 months. no investigational medicine is applied in this prospective follow-up study. patients are requested to report body weight, waist circumferences, blood pressure, diet, physical activities, and laboratory results if available, at 3 monthly intervals during the 6-month follow-up period. patients are also asked if they receive any anti-obesity medication (aom) or participate in any interventional clinical trials indicated for weight management during study period. summary statistics will be respectively applied to examine changes from trial baseline (time at trial randomization, week 0) and study baseline (time at 52 weeks from trial randomization, week 52) to each scheduled follow-up (at week 65 and week 78) by study arms in surmount-cn trial.

Eligibility criteria:
inclusion criteria: * all patients who completed surmount-cn trial are target patients. those who consent to this follow-up study are study participants. exclusion criteria: * those in the surmount-cn trial who denied to participant.
determination of the role of microarray for prognosis and prediction to chemotherapy sensitivity in patients with operable, locally advanced and metastatic oesophageal cancer

Conditions: Oesophageal Cancer

Summary: knowledge of the impact of gene expression profiling could allow optimisation of chemotherapy regimens for individual patients. it could ensure that patients do not receive a particular form of chemotherapy if it is unlikely to benefit them, and in these circumstances an alternative form of chemotherapy that may prove beneficial could be selected. this information will therefore allow chemotherapy to be tailored to the individual tumour. it may help identify those patients with a poorer prognosis who could be selected for further therapy post surgery or a different treatment strategy at the outset.


Eligibility criteria:
inclusion criteria: * any patient with histologically proven operable ,locally advanced and metastatic oesophageal or gastric carcinoma. exclusion criteria: * second malignancy
multisensory telerehabilitation for visual field defects

Conditions: Visual Field Defect Following Cerebrovascular Accident; Hemianopia; Brain Injuries

Summary: brain injuries may cause the loss of the ability to see portions of the visual field, the so-called visual field defects (vfds). vfds significantly impact the survivors' functional recovery and quality of life, with the majority of patients displaying no spontaneous recovery or being left with residual deficits. among the available therapies for vfds, the compensatory scanning training is considered the most promising. yet, current evidence is insufficient to recommend it in clinical practice, and the scientific community has stressed the need of more high-quality research. the present randomized clinical trial in patients with chronic vfds caused by brain lesions aims at verifying the feasibility and efficacy of a novel telerehabilitation using a multisensory scanning therapy, by measuring its effects on visual functions and daily activities, and by looking for neural indicators of the therapy-induced improvements.


Eligibility criteria:
inclusion criteria: * acquired homonymous visual field defect (hvfds) due stroke, traumatic brain injury, tumor, surgery for epilepsy in a chronic stage of illness (time from the lesion \>6 months) * normal hearing * normal or corrected-to-normal visual acuity exclusion criteria: * cognitive decline (adults) * intellectual disability (children) * major neurological or psychiatric disease * being enrolled in another therapy for hvfds not being enrolled in another vfds therapy.
detection of prostate cancer using voided urine

Conditions: Prostate Carcinoma

Summary: this study collects urine from male patients seen at the urology clinic to detect prostate cancer cells, shed in voided urine, using the optical imaging method developed in the laboratory, which targets certain biomarkers expressed on prostate cancer cells. the information learned from this study may allow researchers develop a simple diagnostic test for the management of those patients who have elevated prostate specific antigen (psa) and are suspected to have prostate cancer. it may also help researchers understand the genetic risk factors associated with prostate cancer.

primary objective: i. to detect prostate cancer cells, shed in voided urine, using the optical imaging method developed in our laboratory, which targets vasoactive intestinal polypeptide receptor 1 (vpac1) receptors expressed on prostate cancer cells and validates the results with prevailing condition of the patients/volunteers and evaluate diagnostic accuracy. secondary objectives: i. to establish if the malignant cells as a percent of total cell shed in the urine. ii. to establish the fluorescence intensity around malignant cells. iii. to establish if the vpac protein quantity in shed malignant cells correlate with the aggressiveness of the disease. outline: patients undergo collection of urine samples at baseline during standard of care office/clinic visit.

Eligibility criteria:
inclusion criteria: * provide signed and dated informed consent form * male * patients must be 50-70 years of age * willing to comply with all study procedures * prior to digital rectal exam (dre) * patients with the diagnosis of prostate cancer (cohort 1 n=150) * prior to radical prostatectomy/radiotherapy (xrt) or systemic therapy * may be on active surveillance * patients with elevated psa level but no know prostate cancer (cohort 2 n=150) * diagnosis of bph/lower urinary tract symptoms (luts) * no prior diagnosis of prostate cancer * prior negative biopsy with psa \> 1.5 * without biopsy psa \< 1.5 * patients with normal psa levels (cohort 3 n=200) * no documented history of bph (no medical management or prior surgical treatment for bph) * psa \< 1.5 * no documented history of prostate cancer * no documented history of urothelial carcinoma * patients pre dre and post dre (cohort 4 n=200)\*\* * patients on with a known gleason score (cohort 5= 150) exclusion criteria: • patients under the age of 50
magnetic resonance imaging study on patients with hemifacial spasm

Conditions: Hemifacial Spasm; Magnetic Resonance Imaging

Summary: up to now, multiplanar reconstruction (mpr) has been widely used to detect the neurovascular compressions (nvc) on the patients with hemifacial spasm (hfs). however, due to lack of stereoscopic vision, this traditional method sometimes can not meet the requirement on identifying the details of nvc, especially when the aberrant vessels turn out to be veins not arteries. the three dimensional analytic techniques, such as curved planar reconstruction (cpr) and magnetic resonance virtual endoscopy (mrve), may be helpful to improve the sensitivity and specificity on the demonstration of nvc with stereo and dynamic views, so as to assist the design of the surgical plan. furthermore, the frequent finding of nvc on mri studies of asymptomatic patients incited the creation of several strict criteria for the imaging diagnosis of nvc: the vessel must cross perpendicular to the long axis of the nerve, the nerve must be deviated or indented at the root entry zoon (rez) by the vessel. alternatively, morphological measurement of the nerve may correlate with the severity of facial spasm due to atrophy of the nerve in most cases of hfs, and is likely secondary to the micro-structural abnormalities, such as axonal loss, demyelination, collagen deposition, etc. in this study, cross-sectional area (csa) and volume (v) of the cisternal facial nerve will be assessed to determine whether it can be a useful biomarker for predicting the degree of hfs.


Eligibility criteria:
inclusion criteria: * primary hfs patients according to medical history and typical facial muscle spasms that are unilateral, involuntary, and had intermittent contractions innervated by the ipsilateral facial nerve. the patient has 1 year disease duration at least. exclusion criteria: * secondary causes of hfs, such as tumors or cysts compressing the facial nerve in the cerebellar pontine cistern; precarious general health status; percutaneous lesions or surgical treatments; cardiac pacemaker or metal implants.

Keywords: curved planar reconstruction magnetic resonance virtual endoscopy
retrospective analysis of factors affecting chronic postoperative pain after thoracotomy

Conditions: Chronic Pain Syndrome; Thoracotomy

Summary: the aim of this retrospective study is to determine the factors affecting the development of chronic pain in patients with thoracotomy in the thoracic surgery operating rooms of i̇bn-i sina hospital. by identifying these factors, it is aimed to apply the necessary treatments to prevent the development of chronic pain and to improve patient outcomes.

the study included 229 patients asa 1, 2 and 3, 18 years of age and older, who underwent elective thoracotomy in ankara university i̇bn-i sina hospital, thoracic surgery operating room between 01.01.2016 and 31.12.2020. the medical files and electronic records of the patients were scanned from the system. age, gender, weight, asa score, smoking, comorbidities (hypertension, diabetes), drug use, malignancy, chemotherapy history, radiotherapy history, intraoperative and postoperative analgesia method, duration of acute pain, type of surgery, duration of surgery, duration of anesthesia, rib resection, number of chest tubes and duration time, time to apply to the pain clinic, and the analgesic method applied were recorded.

Eligibility criteria:
inclusion criteria: * asa 1,2 and 3 * 18 year of age and older * underwent elective thoracotomy exclusion criteria: * asa 4 and 5, emergency or trauma thoracotomy, patients with malignancy infiltrating the chest wall, more than one thoracotomy performed, patients whose cardiovascular or cerebrovascular or musculoskeletal system was affected at a level that would affect their daily activities after surgery, and patients with insufficient data for various reasons
study of eye movement desensitization and reprocessing (emdr) working mechanism

Conditions: Post-Traumatic Stress Disorder

Summary: emdr (eye movement desensitization and reprocessing) is an exposure-based procedure for the treatment of patients with post-traumatic stress disorder (ptsd). although the efficiency of emdr-treatment is empirically proven, it remains unclear whether the bilateral stimulation triggered via eye movements has specific effects on treatment outcome. hypothesis explaining the efficacy of the emdr treatment are: focussing on the moving hand triggers an orientation reaction, and the duality of alertness focus during trauma exposition causes a distraction of the traumatic topic. within a randomized controlled study 120 patients will be treated during 8 therapeutical sessions with emdr with bilateral stimulation or one of two control conditions: emdr without bilateral stimulation (eyes on a fixed, unmoving hand) and exposition without any visual stimuli to focus attention on. primary outcome are scores on an interview measure for ptsd symptoms (clinician administered ptsd scale (caps))as assessed pre-treatment and after treatment (max 8 sessions of psychotherapy). the following hypothesis are investigated in the study: 1. emdr treatment with bilateral stimulation through eye movements will be followed significant larger reduction in caps compared with emdr treatment without bilateral stimulation (specific treatment effect of eye movements) 2. emdr with eyes fixed will be followed by a significant larger reduction in caps compared with emdr without external focus (specific treatment effect of distraction)


Eligibility criteria:
inclusion criteria: * the participant is able to reduce stress symptoms * no actual contact to offender exclusion criteria: * drug or alcohol addiction * inability to tell about the traumatic events * cardiac problems

Keywords: standard fixed no focus emdr treatment with bilateral stimulation via eye movement emdr treatment with fixed eyes trauma exposition without external stimulus
validation of a translation into spanish (mexico) of the spinal cord independence measure iii

Conditions: Spinal Cord Injury

Summary: the propose of the study is to validate in mexico a spanish translation of the spinal cord independence measure (scim) version iii, in patients with spinal cord injury (sci). internal consistency, reproducibility and reliability will be addressed scoring the results of the translated version at two time frames and also of the same patients by different examiners (physicians, nurses and technicians).

the worldwide estimated annual incidence of sci has a broad spectrum, ranging from 236 to 1009 cases per million of people. in mexico there is an estimate of 18.1 cases per million people, affecting primary men in their productive age (25-34 years old). most of the patients have disabilities after the injury, and become dependent of their families or professional care providers. the cornerstone treatment in the long therm is rehabilitation and the main goal is to achieve patient independence. over the last two decades many disability measure instruments have been developed, like the functional interdisciplinary measure (fim). this scale though it is very useful for patients' general outcome, it does not grade patients' independence entirely. in 1997, dr. amiram catz developed the first version of the spinal cord independence measure (scim). since its first version, it showed to be a very powerful tool to assess patients' independence. recently, the scim-iii has been validated in a multicenter study, showing validity, reliability and internal consistency. the aim of this study is to perform a translate and trans-cultural adaptation of the scim-iii into spanish and to perform also its validation in mexican population.

Eligibility criteria:
inclusion criteria: * spinal cord injury exclusion criteria: * patient with any other injury/lesion that produces dependence or disability

Keywords: spinal cord independence measure scim spinal cord injury traumatic spine injury
study on the efficacy and safety of chiglitazar sodium in pcos with t2dm

Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries; T2D

Summary: purpose and significance: to explore the clinical efficacy and safety of chiglitazar sodium in polycystic ovary syndrome with type 2 diabetes methods: from october 2022 to september 2024, a total of 142 pcos with t2dm patients admitted to department of endocrinology and metabolism at the affiliated hospital of nantong university were recruited. participants are randomized in a ratio of 1:1 into two treatment groups of 71 participants: ① control group；②experimental group. after randomization, the control group was treated with lifestyle intervention+ metformin+ orlistat (obese patients)+ pioglitazone, and the patients in the experimental group were treated with lifestyle intervention+ metformin+ orlistat (obese patients)+ chiglitazar (32mg qd) until the end of follow-up. the treatment and follow-up period totaled 3 months. observe the body weight, menstrual cycle and blood glucose control and other related indicators. type of study: randomized controlled, prospective, intervention study.

from october 2022 to september 2024, a total of 142 pcos with t2dm patients admitted to department of endocrinology and metabolism at the affiliated hospital of nantong university were recruited. participants are randomized in a ratio of 1:1 into two treatment groups of 71 participants: ① control group；②experimental group. after randomization, the control group was treated with lifestyle intervention+ metformin+ orlistat (obese patients)+ pioglitazone, and the patients in the experimental group were treated with lifestyle intervention+ metformin+ orlistat (obese patients)+ chiglitazar (32mg qd) until the end of follow-up. the treatment and follow-up period totaled 3 months. observe the body weight, menstrual cycle and blood glucose control and other related indicators.

Eligibility criteria:
inclusion criteria: clinical diagnosis of type 2 diabetes mellitus clinical diagnosis of polycystic ovarian syndrome must be able to swallow tablets exclusion criteria: mental diseases, autoimmune diseases, hematological diseases, malignant tumors, other ovarian diseases (such as ovarian cysts), sexually transmitted diseases infertility caused by gynecological diseases such as uterine cat's eye disease and other reasons abnormal function of important organs congenital adrenocorticosis, hypothyroidism, cushing's syndrome and other endocrine diseases patients who have recently prepared or become pregnant