Kornimate/medical-research-clean huggingface dataset:
complementary and alternative medicine among outpatients with inflammatory rheumatic diseases in western sweden

Conditions: Rheumatic Diseases

Summary: this is an observational study aiming to study the use of complementary and alternative medicine (cam) drugs and methods among patients with inflammatory rheumatic diseases, at rheumatology clinics in western sweden and also to investigate possible associations between cam using habits and other characteristics of the patients.

complementary and alternative medicine (cam) is treatment that primarily is given outside the institutions where conventional medicine is practised. cam drugs are substances that often have a natural origin and are taken orally or used topically, for self-treatment. cam methods are therapies where the patient often goes to a practitioner, for example acupuncture, massage, homeopathy or chiropractics. most cultures have their own history of traditional treatments, with herbal medicine or spiritual healers. the use of complementary and alternative medicine (cam) is widespread and increasing in many countries. the sales figures in sweden for cam drugs, functional foods and dietary supplements have increased from 450 million to 4250 million sek between 1980 and 2007. many people of today use cam as a complement, rather than an alternative, to conventional healthcare. some alternative methods, like acupuncture and massage, have also been integrated into conventional medicine. the biological effects of drugs containing herbs or animal parts are often unknown and there is a hazard of interaction with prescribed medication. the use of cam drugs is often not communicated by the patient to the physician. a swedish point observation study of patients admitted to sahlgrenska hospital 2004 showed that 69 % of the patients had used cam drugs at any time in their life, but only 27,5% had informed their doctor about it. the use of cam drugs was seldom documented in the medical records of the patient. the utilization of cam among patients with rheumatic diseases in sweden has never been studied before. the aim of this trial was to study the use of cam methods and cam drugs among patients seen at rheumatology practises in the west of sweden. to investigate which methods and drugs that are being used and to see if there are connections between using habits and factors like gender, age, rheumatic diagnoses, disease activity, medication and the patients experience of pain, fatigue and general health. we were also interested in finding out the reason for use of cam, and if the patients had experienced beneficial effects or side effects of the use.

Eligibility criteria:
inclusion criteria: * patients were eligible for inclusion if they were attending the rheumatology clinic and had had an appointment there before. exclusion criteria: * patients were excluded if they were on their first visit to the practice, had dementia or had difficulties understanding swedish.

Keywords: complementary alternative medicine
iron supplement effect on child development

Conditions: Neurodevelopmental Disorders; Lactation

Summary: objective: to evaluate the effect of iron supplement with two different amounts (one in the higher limit and another in the lower limit of the suggested amount) according to the presence of mutations in the hfe gene in the physical, immune and neurobehavioral development in the 6 to 12 moth toddlers. methodology: subjects: 340 toddlers coming from paediatric serves of sant joan hospital. methods: at 6 and 12 months it done clinical history, food registry, biochemist determinations: haemoglobin, iron, transferrin, ferritin, reactive c protein and immune response (il4, il10, il6 ifn, iga, igm, igg, ige). mutations in the hfe gene: c282y, h63d, s65d and hepcidin gene. mental, psychomotor and behavioual development (bayley scales of infant development 2on edition: 1993). we evaluate the level of language and communication (macarthur), regulation and sensory process (infant toddler symptom checklist), familiar and environment surroundings (scale health general parental stress index).

design: randomised clinical trial with two groups of intervention. group a received high-iron fortified milk (1.2mg/100ml) and group b received low-iron fortified milk (0.4mg/100ml). inclusion criteria: caucasian new-borns, term infants. exclusion criteria: * families that refuse enter at the follow-up. * low-birth weight or preterm infants. * anaemic infants. * infants with congenital defects, immunodeficiency or hypothyroidism. * infants with diseases that requires intensive care.

Eligibility criteria:
inclusion criteria: * caucasian infants * healthy term infants exclusion criteria: * families that do not understand spanish or catalan * anaemic infants at birth * infants with important diseases

Keywords: neurodevelopment bayley scale growth iron fortification
the effect of sevoflurane on airway hyperreactivity during the perioperative period.

Conditions: RSV Infection in Children Less Than 5 Years of Age; General Anesthesia

Summary: to investigate the effects of sevoflurane on respiratory parameters and respiratory inflammation in healthy and rsv-infected under general anesthesia and to propose suitable perioperative airway protection measures for children with respiratory virus infection undergoing general anesthesia.


Eligibility criteria:
inclusion criteria: 1. patients voluntarily joined this study and signed an informed consent form； 2. age: 2-5 years old； 3. the patient should have a good general condition and no serious internal medicine comorbidities (asa classification of the american anesthesiology association is grade i); bmi ≤ 20; 4. plan to undergo elective adenoidectomy or adenotonsillectomy with tracheal intubation. exclusion criteria: 1. children with a history of allergic asthma; 2. children with space-occupying lesions of the chest and lungs, or acute bronchiolitis or pneumonia; 3. children with cardiovascular diseases that may cause cough, wheezing, and other symptoms; 4. children who used leukotriene modulators, β2 receptor agonists, anticholinergics, theophyllines, or hormonal treatment drugs within two weeks; 5. children allergic to propofol, sevoflurane, or other anesthetic agents; 6. children with a family history of malignant hyperthermia; 7. children with liver and kidney dysfunction; 8. the result of rapid antigen detection and nucleic acid test for rsv was inconsistent, or children combined with pathogen infections other than rsv; 9. children with fever.

Keywords: sevoflurane general anesthesia rsv infection pediatric patients
electrical pharyngeal stimulation for dysphagia therapy in tracheostomized stroke patients

Conditions: Stroke; Dysphagia

Summary: the purpose of this study is to evaluate whether electrical pharyngeal stimulation in addition to standard care can enhance short-term swallow recovery in tracheostomized dysphagic stroke patients and thereby facilitate earlier decannulation compared to sham treatment plus standard care.

readiness for decannulation is assessed after three days of either real or sham electrical pharyngeal stimulation. in case a patient cannot be decannulated at that time point, there is an open-label follow-up treatment phase, in which every patient in the sham treatment arm gets another three days of real electrical pharyngeal stimulation to not deprive any patient of a potentially beneficial treatment.

Eligibility criteria:
inclusion criteria: * severe dysphagia due to acute stroke * completely weaned from mechanical ventilation * impossibility of decannulation because of severe dysphagia with ongoing aspiration exclusion criteria: * preexisting dysphagia * comorbidities that can possibly cause dysphagia * psychiatric comorbidities * pacemaker or other implanted electronic devices

Keywords: electrical pharyngeal stimulation stroke-related dysphagia tracheostomy decannulation
evaluation of pcr using dna extract from slides and filter paper for the detection of tuberculosis and mdr-tuberculosis

Conditions: Tuberculosis; Multi Drug Resistant Tuberculosis

Summary: specimen transport from peripheral health structures to the national tb reference laboratory for mdr-tb identification presents a big challenge in term of sample management, safety, contamination and delays. thus a system that allows specimen to be collected and shipped in a safely manner while reducing the possibilities of contamination, the cost of shipment and especially the time for detection of mdr-tb by using molecular methods would be very useful. whereas the some studies show promising results for the development and standardization of simple specimen collection and transportation methods for molecular dst, more data is needed before these can be used in routine. the study described here aims at identifying a suitable method, in terms of adapted sample support (s) (slide, filter paper (fta, genocard ...)) and dna extraction method. if one or several methods are found to give satisfying results, then a larger patient based evaluation of this (these) method(s) for molecular dst will be performed in a second phase. the protocol for the second phase will be prepared separately.

the main objective of this study is to evaluate the performance of pcr in identification and detection of tuberculosis using dna extracts from stained slides (ziehl neelsen and fluorescence) and filter paper (fta card and genocard). the secondary objectives of this study are to assess the mtb extraction yield from smear-negative, low and high bacilli load specimens on slides, filter paper ( genocardand fta), to determine the amount of sample required to make a detectable pcr reaction and to assess the feasibility of storage and extraction methods.

Eligibility criteria:
inclusion criteria: * tb suspect with cough more than 2 weeks exclusion criteria: * none

Keywords: tuberculosis tb mdr-tb lipa filter paper slides mtbdr plus
blood flow restricted resistance training in peripheral arterial disease

Conditions: Peripheral Arterial Disease

Summary: a randomised controlled trial evaluating the feasibility and acceptability of a 12 week lower body blood flow restricted resistance exercise programme for people with peripheral arterial disease.

the primary aim of this study is to determine the feasibility of 12 weeks of lower body resistance exercise performed with blood flow restriction (bfr) in people with peripheral arterial disease. resistance exercise with bfr involves placing inflatable cuffs proximal to the exercise limbs in order to manipulate blood flow and enhance the training response. secondary aim of this study is to evaluate changes in abpi, muscle size, strength and physical function at mid-and post- intervention.

Eligibility criteria:
inclusion criteria: * men and women with pad 6 months post diagnosis. * ankle-brachial pressure index \<0.9. * people physically able to perform leg press and leg extension resistance exercise. exclusion criteria: * ankle-brachial pressure index \>0.89. * people unable to visit the laboratory twice weekly for exercise sessions. * people unable to do leg press and leg extension exercise. * people whose walking is limited by a non-pad condition. * people with pad with critical limb ischemia (including symptoms of pain at rest and skin ulcers). * people with dementia. * people who have had major surgery or myocardial infarction within the past 6 months. * previous stroke. * previous thrombosis. * people who have major surgery scheduled during the intervention period.

Keywords: blood flow restricted resistance exercise feasability
the effect of the intrapartum care model given in line with who recommendations on the birth process and care

Conditions: Birth Outcomes; Labor Pain and to Reduce Pain; Fear of Birth; Birth Comfort; Perception of Midwifery Care; Birth Period; Oxytocin Deficiency; WHO Intrapartum Care Recommendations

Summary: this study aimed to evaluate the effects of the intrapartum care model provided in line with the world health organization (who) recommendations on labor pain, fear, comfort, duration, oxytocin use and perception of midwifery care.

the research is a randomized controlled trial. the research was conducted with 124 primiparous pregnant women (intervention group n=62, control group n=62) who were hospitalized in the delivery unit of aksaray training and research hospital between september 2023 and january 2024. the pregnant women in the intervention group were given the intrapartum care model in line with who recommendations after cervical dilation reached 5 cm. the control group received only the standard intrapartum care in the hospital. data were collected using the personal information form, labor and postpartum follow-up form, visual analog scale (vas), labor comfort scale (dks), intrapartum fear of labor scale, and women's perception of supportive care given during childbirth scale. vas, dks, and fear of childbirth scale were applied to women in both groups when cervical dilation was 5 cm and 9 cm. after birth, the women's perception of supportive care given during childbirth scale was applied.

Eligibility criteria:
inclusion criteria: * being 18 years of age or older, * history of term pregnancy (38-42 weeks), * having a primiparous, * single, healthy, vertex positioned fetus, * having no complications that may cause dystocia in labor (such as contraction anomalies, birth object, * birth canal dystocia, dystocia related to the mother's psychology), * having a partner/husband, * history of cervical dilatation of 5 cm or more, * being able to speak and understand turkish exclusion criteria: * those with maternal and fetal complications (oligohydramnios and polyhydramnios, placenta previa, preeclampsia, premature membrane rupture, presentation anomalies, intrauterine growth retardation, fetal anomalies, intrauterine death, macrosomic baby, etc.), * those with any complications that prevent vaginal delivery, * elective caesarean section, those who became pregnant with assisted reproductive techniques, * those who are multiparous, * those who have chronic diseases (such as hypertension, diabetes, heart disease).

Keywords: who intrapartum care recommendations labor pain and to reduce pain fear of birth birth comfort perception of midwifery care birth period oxytocin deficiency
usability evaluation of menai cpap masks

Conditions: Obstructive Sleep Apnea

Summary: the primary objective of this study is to evaluate the subjective performance of the menai mask systems (full face, nasal, and pillows variants), compared against comparison mask systems.

the study will evaluate the subjective seal, comfort, stability, usability, and humidification performance of the prototype mask systems in cpap established patients. the performance of the prototype menai mask systems (full face, nasal, and pillows variants) will be subjectively assessed through user questionnaires based on an 11-point likert scale, and will be compared against comparison masks. the prototype masks share the same parts (cushion, frame, headgear), with the difference being that the menai masks feature a novel vent and humidification system.

Eligibility criteria:
inclusion criteria: * participants willing to provide written informed consent * participants who can read and comprehend written and spoken english * participants who are over 18 years of age * participants who have been diagnosed with osa * participants who have been established on cpap for ≥ 6 months * participants who are currently using the same mask type/variant as the interventional mask system to be evaluated exclusion criteria: * participants who are not able to provide written informed consent * participants who are unable to comprehend written and spoken english * participants who are pregnant * participants who are unsuitable to participate in the study in the opinion of the researcher * participants with a pre-existing lung disease or a condition that would predispose them to pneumothorax (e.g. copd, lung cancer; fibrosis of the lungs; recent (\< 2years) case of pneumonia or lung infection, lung injury) * participants who cannot participate for the duration of the trial * participants who are established on bi-level support therapy * participants who are not currently using the same mask type/variant as the interventional mask system to be evaluated

Keywords: sleep apnea osa cpap
the effect of guided imagery and music therapy on post-operative recovery after gynecological oncology surgery

Conditions: Ovarian Cancer; Uterine Cancer

Summary: this pilot study will be a prospective, randomized trial which will take place at the university of minnesota medical center (ummc). eligible patients will be identified at the time of their first clinic visit. if selected to be involved in the study, the patients will be randomized to one of three different groups: a guided imagery and music therapy group (gimt) or one of two control groups.

the gimt group will undergo a standardized regimen of peri-operative guided imagery and music therapy guided by cds. as there are no studies which discuss whether the act of listening to any therapy will affect outcomes, we will also explore whether white noise can affect outcomes as well. therefore, one control group (wn) will abide by the same regimen and will listen to a cd with white noise; the other control group (cp) will have no intervention at all and will follow our current peri-operative procedures.

Eligibility criteria:
inclusion criteria: * subjects will include women who are being seen at the women's health center by the gynecological oncology group at the university of minnesota (ummc). these women will be considered for inclusion based on their projected surgery: exploratory laparotomy. subjects will have to have their surgery at the ummc within 1 month of their clinic visit. patients may be undergoing surgery for either known cancer (ovarian or uterine) or high suspicion for malignancy. exclusion criteria: * \< 19 years old * pregnant * undergoing a procedure other than laparotomy * scheduled to be discharged the same day of surgery * chronic narcotic pain medication users * if they are currently using or planning on using other complementary alternative medicine (cam) therapies prior to or after surgery.
respiratory variations for predicting fluid responsiveness 2

Conditions: Sepsis; Circulatory Failure; Respiratory Physiological Phenomena

Summary: objectives: to investigate whether respiratory variations of inferior vena cava diameters (civc) predict fluid responsiveness in spontaneously breathing patients with septic acute circulatory failure and irregular heartbeats. design: prospective, bicentric study, intensive care units. patients and measures: spontaneously breathing patients with sepsis and clinical signs of acute circulatory failure are included. a positive response to fluid loading (fl) is defined as an increase of the stroke volume (sv) \>10%. the investigators measured the minimum inspiratory and maximum expiratory diameters of the ivc (idivc and edivc) during standardized (st) and unstandardized (ns) breathing. the investigators calculated civcst and civcns before a 500ml-colloid fl.


Eligibility criteria:
inclusion criteria: * adult patients of the intensive care units of the lille university-hospital and of the valencienne general hospital. * age greater than or equal to 18. * patient insured * spontaneous breathing without ventilatory support or intubation or tracheotomy. * irregular cardiac rhythm * prescription by the physician in charge of the patients of a 500 ml volume expansion in less than 30 minutes. * patients with sepsis with at least one sign of acute circulatory failure: * tachycardia with heart rate\> 100/min * systolic blood pressure \ 40mmhg in previously hypertense patient * oliguria \<0.5ml/kg/hour for at least one hour * skin mottling exclusion criteria: * high-grade aortic insufficiency * transthoracic echogenicity unsuitable for measuring the stroke volume or inferior vena cava diameters * clinical signs of active exhalation * clinical or ultrasonographic evidence of pulmonary edema due to heart failure * pregnancy * abdominal compartment syndrome * regular cardiac rhythm

Keywords: vena cava fluid sepsis echocardiography ultrasound ultrasonography collapsibility index circulatory failure irregular cardiac rhythm fluid responsiveness spontaneous breathing
laboratory diagnosis of of rickettsial and rickettsia-like diseases

Conditions: Rickettsioses

Summary: the low confirmed rickettsioses cases rate may indicate the presence of rickettsiosis other than scrub typhus, murine typhus, and q fever. the clinical presentation of rickettsiosis is variable and atypical that laboratory confirmation is necessary. this project is aimed to set up the laboratory to diagnose rickettsial and rickettsial like disease, which could help in develop rapid diagnostic kits, epidemiologic surveillance and prognostic factor.


Eligibility criteria:
inclusion criteria: * rickettsioses reported cases

Keywords: rickettsioses scrub typhus q fever typhus fever spotted fever rickettsioses reported cases
gastric slow wave and autonomic nervous function in cirrhotic patients with esophageal varices after ligation-a clinical research

Conditions: Esophageal Varices in Cirrhosis of the Liver

Summary: this study is intended to include 20 patients with esophageal varices caused by liver cirrhosis who were admitted to the first affiliated hospital of nanjing medical university from may 2019, and randomly select 8 patients with gastric polyps as the control group.general clinical data, imaging data, endoscopic data and laboratory indicators were collected.electrogastrogram (egg) and heart rate variability (hrv) were performed before and 24 hours after operation in patients with cirrhotic esophageal varices, and the dyspepsia scale was filled out.electrogastrogram (egg) and cardiac variability (hrv) were performed in patients with gastric polyps 24 hours before and after surgery, and the dyspepsia scale was filled.egg uses the surface electrode to record gastric myoelectric activity, and evaluates the patient's gastric rhythm by normal slow wave ratio, overspeed ratio, overslow ratio, and rhythm disorder ratio.the hrv evaluates the balance state of the patient's autonomic nervous system with high frequency (hf)/low frequency (lf).spss software was used for paired sample analysis of experimental results.


Eligibility criteria:
inclusion criteria: * patients over 18 years old with cirrhosis of esophageal varices who underwent endoscopic ligation * signed informed consent exclusion criteria: * hemorrhage in the digestive tract, unstable vital signs * hepatic encephalopathy * unwilling to cooperate with the examiner * skin allergies