Kornimate/medical-research-clean huggingface dataset:
head awareness in chronic migraine patients

Conditions: Migraine

Summary: research indicates that different beliefs about the nature of back problems and their future consequences direct behaviors that may cause falsely stimulated neuroplastic changes. the central nervous system can help relieve ongoing pain by regulating nociceptive activity. for this purpose, "the fremantle back awareness questionnaire" was developed to evaluate the perceptual awareness status of the back. in individuals with chronic pain, changes in body perception can be explained by the cortical reorganization that occurs in these individuals. compared to healthy individuals, cortical thickness is reduced in the brain regions that process pain in chronic migraine patients. on the other hand, it is stated that these cortical structural changes can be reversed and recovery can be achieved by treating headache and related symptoms in chronic migraine patients. individuals try to continue their daily lives with impaired body awareness due to pain. decreased awareness has been studied in many neck, back and knee pain studies in the literature with fremantle awareness questionnaires in different societies. in these studies, the awareness of individuals experiencing pain was found to be low and it was found that neck, waist or knee awareness was related to pain intensity, pain catastrophizing, disability, quality of life, anxiety, depression and kinesiophobia. it was even determined that awareness increased with treatments. although reversible structural changes in the cortical regions of chronic migraine patients have been investigated with radiological imaging methods and are still being investigated, not every patient can be evaluated with radiological imaging in clinics due to cost and time problems. therefore, a fast, practical and understandable questionnaire evaluation can benefit clinicians. when the literature is examined, there is no study evaluating the perceptual level and nociceptive awareness in chronic migraine headache. conducting a validity and reliability study of the "fremantle headache awareness questionnaire" developed from the fremantle back awareness questionnaire in turkish society can provide objective results in evaluating the effectiveness of treatment as a practical evaluation method in clinics. hypotheses: h0: the fremantle headache awareness questionnaire is not valid and reliable for the turkish population in chronic migraine patients. h1: the fremantle headache awareness questionnaire is valid and reliable for the turkish population in chronic migraine patients.


Eligibility criteria:
inclusion criteria: * being diagnosed with chronic migraine * being between the ages of 18-70, * being able to read, speak, understand and write turkish in order to understand the items/questions of the surveys and scales and to give correct answers. exclusion criteria: * having any headache diagnosis other than chronic migraine, * having a history of any systemic disease such as malignant, inflammatory, acute fracture/infection, surgery, neurological, psychological, rheumatological. * having neck or back pain

Keywords: migraine awareness headache
vitamin d during pregnancy

Conditions: Vitamin D Deficiency

Summary: vitamin d insufficiency is common globally. pregnant women, who need an increased supply of this vitamin for the proper development of the fetus, are a significant risk group. the purpose of this study is to examine which factors - education, knowledge from non-professional sources, recommendations from medical staff - influence the use of vitamin d among pregnant women in light of the lack of a clear health policy, and to help formulating guidelines for a new health policy with specific recommendations for vitamin d dosage in pregnancy.


Eligibility criteria:
inclusion criteria for the pregnant of newly post-partum women: * women between 18-50 * pregnant or just given birth and still hospitalized * understand and can read hebrew exclusion criteria: * those who do not understand or read hebrew

Keywords: pregnancy vitamin d
do patient-centric mhealth programs improve patient engagement and health outcomes.

Conditions: Diabetes

Summary: the "intellih" (brand name of the mobile health application) diabetes study is to understand the usage of a mobile health application, intellih, and connected wireless devices such as glucometer by the diabetic patients and ascertain if there are any improvements in short-term health outcomes.

the proposed pilot program is the first of its kind in the nation to use a product, "intellih" - intelligent health for all, that combines four key technologies in one platform: 1) mobile health application (mhealth) app and web portal, 2) wireless sensors and wearable devices, 3) secure text messaging when both sender and receiver are logged in to the system and video-based patient interaction, and 4) remote health monitoring. the purpose of this pilot program is to understand a) usage and adoption of these technologies by providers and patients, and b) document the short-term improvements in health outcomes in a diabetic population. this pilot study will follow 20 diabetic patients (type 1 or type 2) as they beta-test this system, and will acquire data on consented subjects over a period of six months.

Eligibility criteria:
inclusion criteria: * a1c greater than or equal to 6.5%. * age greater than or equal to 18 years. * ability to comply with study protocol. * available and usable internet facilities at home. * availability and usable smart phone. exclusion criteria: -inability to comply with instructions and directions.
av nodal reentrant tachycardia study

Conditions: Tachycardia, Atrioventricular Nodal Reentry

Summary: the purpose of this study is to determine/identify what mechanisms/factors are involved with regard to av nodal reentrant tachycardia.

hypotheses: 1. the tendon of todaro forms a line of block during slow/fast avnrt preventing the atrial impulse from entering the triangle of koch (and perhaps providing sufficient time for activation to pass through the coronary sinus coat to activate the posterior extensions of the av node as is critical to maintenance of tachycardia) 2. the coronary sinus myocardial coat participates in all of the forms of avnrt. the reentrant circuit is thus not confined within the triangle of koch and sites remote from the compact av node could be targeted for ablation reducing the risk of av conduction block. 3. a model of the reentrant circuit can be created for each patient's tachycardia, using the site of earliest retrograde activation to suggest the retrograde limb and the resetting response to suggest the anterograde limb. data analysis/statistics: resetting and mapping of av nodal reentrant tachycardia: pacing will be analyzed to see at which sites, the tachycardia can be reset by the latest extra-stimuli (i.e., with the least advancement in local activation). the coupling interval will be compared to the latest extra-stimulus capable of resetting (advancing) the tachycardia from the postero-septal tricuspid annulus. ablation results: the patients will act as their own reference, since the standard ablation technique in the postero-septal space is being performed first and tested for efficacy. the mcnemar test will be applied to compare the efficacy of ablation at the postero-septal tricuspid annulus alone (standard ablation), with the efficacy of this ablation plus ablation within the coronary sinus. from our initial observations, it is anticipated that the additional ablation in the coronary sinus will increase the efficacy of the procedure from \ 98%, such that 100 cases should provide sufficient data to reach statistical significance.

Eligibility criteria:
inclusion criteria: * ages 16-80 * at least one documented episode of av nodal reentrant tachycardia * patient scheduled for electrophysiology study and catheter ablation for supraventricular tachycardia exclusion criteria: * ages \ 80 * medical condition significantly increasing risk of extending procedure time or x-ray exposure * pregnancy * prior ablation with radiation exposure \>2 hours * electrophysiology study performed without sedation or anesthesia * unavailable for follow-up

Keywords: avnrt atrioventricular nodal reentrant circuit nodal reentrant tachycardia paroxysmal supraventricular tachycardia
cyberknife for early stage breast cancer

Conditions: Early Stage Breast Cancer

Summary: this phase ii study based on the cyberknife society study will evaluate the technical feasibility and acute toxicity of partial breast irradiation (pbi) with the cyberknife. it will evaluate quality of life (qol) issues as they relate to treatment-related side effects, cosmetic result and patient convenience. it will evaluate outcome in terms of local control in the treated breast. radiosurgery is defined as the stereotactic delivery of ionizing radiation in 5 stages or less to a designated target with sub-millimeter accuracy. radiosurgery in the context of this protocol will be given to the region of the tumor bed with 7 weeks of the lumpectomy and sent/axillary node sampling over the period of five to ten days using the cyberknife (ck) or within the 7 weeks of the last chemotherapy treatment if given.


Eligibility criteria:
inclusion criteria: * patients with stage 0, i, or ii (tis, ti, or t2 \<=3cm \& no) histologically confirmed invasive non-lobular carcinoma or ductal carcinoma in situ of the breast with a lesion \<= 3 cm, treated with wide excision. * negative inked histologic margins of excision or reexcision and clear of invasive tumor and dcls by at least 2mm * negative post-excision or post-reexcision mammography if cancer presented with malignancy-associated microcalcifications; no remaining suspicious microcalcifications in the breast before radiotherapy. * no involved axillary lymph nodes by routine histologic examination (h\&e) of sentinel node(s) or of nodes identified from axillary dissection. * enrollment and initiation of cyberknife therapy within 42 days of last breast cancer surgery or last chemotherapy treatment. exclusion criteria: * patients with invasive lobular carcinoma or nonepithelial breast malignancies such as sarcoma or lymphoma. * patients with multicentric carcinoma or with other clinically or radiographically suspicious areas in the ipsilateral breast unless confirmed to be negative for malignancy by biopsy. * patients who are pregnant. * patients who have any histologically confirmed positive axillary nodes. * patients with collagen vascular diseases, specifically systemic lupus erythematosis, scleroderma, or dermatomyositis with a creatine phosphokinase level above normal or with an active skin rash.
clinical study on syb l-0501 in patients with indolent b-cell non-hodgkin's lymphoma or mantle cell lymphoma

Conditions: Non-Hodgkin's Lymphoma; Mantle Cell Lymphoma

Summary: the purpose of this study is to assess the antitumor effects and safety of bendamustine hydrochloride (syb l-0501) in patients with indolent b-cell non-hodgkin's lymphoma or mantle cell lymphoma.

indolent b-cell non-hodgkin's lymphoma is treated mainly with radiation and chemotherapy using a combination of chemotherapies, such as purine-analogues and chop (cyclophosphamide, doxorubicin, vincristine and prednisolone). after the approval of an antibody therapy agent rituximab®, it alone or combination with chop has been introduced. bendamustine hydrochloride has a unique structure compared with the marketed agents, and has an innovative mechanism of action. thus, it is expected that bendamustine hydrochloride will provide new alternatives for patients with refractory/recurrent indolent b-cell non-hodgkin's lymphoma.

Eligibility criteria:
inclusion criteria: non-hodgkin's lymphoma patients with prior therapy who satisfy the conditions listed below. no restrictions regarding gender. * patients with histologically or cytologically confirmed indolent b cell non-hodgkin's lymphoma or mantle cell lymphoma. * patients who had not received treatment for at least 4 weeks (for at least 12 weeks in the case of antibody therapy) after completion of prior therapy and who are judged to carry no effect from the prior therapy. * patients aged from 20 to less than 75 years. * performance status (p.s.): 0 or 1. * patients with adequately maintained organ functions (e.g., bone marrow, heart, lung, liver, and kidney functions). * patients from whom written consent to participate in this study has been obtained. exclusion criteria: patients who meet any of the following criteria will be excluded. * patients with apparent infections. * patients with serious complications (hepatic failure or renal failure). * patients with complication or history of serious heart failure (e.g. cardiac infarction, ischemic heart disease). * patients with serious digestive symptoms (nausea/ vomiting/ diarrhea). * patients who are known to be positive for hbv, hcv or hic. * patients receiving other investigational drugs within 3 months before registration in the study. * patients with allogenic bone-marrow transplant. * women who are pregnant, of childbearing potential, or lactating. * patients who do not agree to contraception. * otherwise, patients who are judged by the investigator as being unsuitable for inclusion in the study.

Keywords: non-hodgkin's lymphoma mantle cell lymphoma
fetal magnetic resonance imaging: z-score reference ranges for a large patient population in normal neuroimaging measurement

Conditions: Fetal Growth Retardation; Fetal Neurodevelopmental Disorder

Summary: this study aims to establish the z score reference ranges of fetal head circumference and other measurement of fetal measurements including biparietal diameter, fronto-occipital diameter, length of the corpus callosum, lateral ventricle, transverse cerebellar diameter, height of the vermis, anteroposterior diameter of the vermis，height and width of normal fetuses from 18 to 40 weeks' gestation. method-a cohort-based study was conducted on low-risk singleton pregnancies with healthy fetuses. the measurement was performed using simple 2-dimensional mri on the typical fetal standard view. the reference ranges were constructed according to gestational age (ga), biparietal diameter (bpd), as independent variables based on the best-fit models, both mean and standard deviation (sd).


Eligibility criteria:
inclusion criteria: * the pregnant women in born in guangzhou cohort study exclusion criteria: * the fetuses with prenatal diagnosis of congenital heart disease or other congenital diseases. the fetuses who are high-risk neonates at the delivery.1) preterm infants; (2) infants with extremely low birth weight (elbw) or who are small for gestational age (sga);

Keywords: z-score healthy reference range
continuous versus interrupted abdominal wall closure after emergency midline laparotomy

Conditions: Laparotomy; Hernia

Summary: patients undergoing primary midline laparotomy for an emergency surgical intervention with a suspected septic focus in the abdominal cavity.

more than 700.000 open abdominal surgeries (laparotomies) are performed each year in germany (2). a major surgical complication after laparotomy is abdominal fascia dehiscence which might appear either as early (burst abdomen with evisceration) or as late complication (incisional hernia). these patients usually undergo surgery for secondary fascial closure associated with markedly increased morbidity (3) including high recurrence rates (up to 45%) (4). the applied surgical strategy of abdominal wall closure (i.e. the combination of suture technique and material) is of high relevance for prevention of fascia dehiscence and, moreover, constitutes the main factor directly controllable by the surgeon. while several randomized controlled trials (rct) (3; 5-8) as well as meta-analyses (9-12) exist that address the issue of optimal fascia closure in elective laparotomies, there is no rct dealing exclusively with the emergency setting. as a result abdominal fascia closure is performed according to the surgeon's individual preference rather than according to evidence-based data. therefore, the present rct is designed to compare the most established strategies (continuous slowly absorbable sutures and interrupted rapidly absorbable sutures) for abdominal wall closure in order to determine differences between both strategies after midline incisions.

Eligibility criteria:
inclusion criteria: 1. preoperative inclusion criteria: * age equal or greater than 18 years * expected survival time more than 12 months * patients undergoing primary and emergency midline laparotomy (patients with prior laparoscopy (not colon resections) or minor abdominal operation (e.g. appendectomy, cholecystectomy, hysterectomy, sectio) may be included into the trial) * suspected septic abdominal focus (e.g. perforated stomach ulcer, perforated diverticulitis) * informed consent 2. intraoperative inclusion criteria before closure: * successful source control * abdominal lavage exclusion criteria: 1. preoperative exclusion criteria: * participation in another intervention-trial with interference of intervention and outcome of this study 2. intraoperative exclusion criteria before closure: * planned re-laparotomy

Keywords: abdominal wall
determining the glycemic effects of three types of spaghetti

Conditions: Potential Abnormality of Glucose Tolerance; Appetitive Behavior

Summary: this study investigated the effects of thee types of spaghetti no7 on the glycemic response

this study aimed to 1. determine the glycemic index and glycemic load of thee spaghetti no7 types (regular, whole wheat and high fiber-low carbohydrates) and 2. investigate the effects of these spaghetti types on postprandial glycemic response in healthy subjects

Eligibility criteria:
inclusion criteria: * healthy * non-smoking * non-diabetic men and women * body mass index between 18 and 25 kg/m2 exclusion criteria: * severe chronic disease (e.g. cardiovascular diseases, diabetes mellitus, kidney or liver conditions, endocrine conditions) * gastrointestinal disorders * pregnancy * lactation * competitive sports * alcohol abuse * drug dependency

Keywords: blood glucose spaghetti glycemic index glycemic load
promoting gynecologic cancer patients with frailty to achieve functional recovery

Conditions: Malignant Female Reproductive System Neoplasm; Gynecologic Cancer; Gynecologic Neoplasm

Summary: this study seeks to understand how frailty, a term that describes people who are more vulnerable stressors such as a new medical problem, affects the outcomes and quality of life in adult patients with gynecologic cancer.

primary objective: i. assess the risk factors associated with frailty in newly diagnosed gynecologic cancer participants. secondary objectives: i. compare primary quality of life endpoint of "healthy days at home" between non-frail and frail participants (primary quality of life endpoint). ii. compare other perioperative, oncologic, and quality of life outcomes between non-frail and frail participants. outline: this is an observational study. all new patients being evaluated for a new diagnosis of gynecologic cancer by the university of california, san francisco (ucsf) gynecologic oncology service and the dana-farber cancer institute will be recruited in both the outpatient or inpatient setting. study participants will be enrolled at the time of diagnosis and followed for up to one year after undergoing surgery for cancer.

Eligibility criteria:
inclusion criteria: * age 18 years or greater * undergoing evaluation for a newly diagnosed gynecologic malignancy * ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it exclusion criteria: * contraindication to any study-related procedure or assessment * does not speak a language for which the consent form and study materials are available

Keywords: frailty risk factors
anorectal manometry of patients with constipation predominant ibs

Conditions: Constipation-predominant Irritable Bowel Syndrome

Summary: the aim of the study is to compare between the anorectal manometric profile of patients with functional constipation and patients with constipation predominant irritabe bowel syndrome

chronic constipation (cc) is a common medical problem throughout the world \[1-3\] the global prevalence of cc in the community varies from 11% to 18% \[4\]. in patients presenting to tertiary care facilities, specific pathophysiological abnormalities like defecatory disorder and slow colonic transit contribute to cc. cc has a significant burden on the utilization of healthcare resources, including the cost of inpatient and outpatient care, laboratory tests, and diagnostic procedures \[5, 6\]. cc is characterized by difficulty in passing stools or a low frequency of bowel movements, often accompanied by straining during defecation or a feeling of incomplete evacuation \[7, 8\]. for western population, cc is defined by bristol stool form (bsf) i-ii, while in indian patients, addition of type iii bristol stool form increases diagnostic sensitivity \[2\]. in the rome iv criteria, it has been suggested that all patients with cc without evidence of structural or metabolic abnormalities to explain symptoms should be considered under the umbrella of functional constipation (fc) \[8\]. fc is defined as the presence of two or more of the followings during the previous 3 months: 1. defecatory straining (\> 25% of bowel movements) 2. hard or lumpy stools (\> 25% of bowel movements) 3. feeling of incomplete evacuation (\> 25% of bowel movements) 4. defecatory obstruction (\> 25% of bowel movements) 5. manual maneuvers to facilitate defecation (\> 25% of bowel movements) 6. fewer than three spontaneous complete bowel movements per week. symptoms must be present for at least 6 months before the diagnosis, and diarrhea must not be present except after using a laxative \[8\]. patients with fc should not meet irritable bowel syndrome (ibs) criteria, although bloating may be present. in contrast, patients with irritable bowel syndrome with constipation (ibs-c) have abdominal pain as the predominant symptom along with bristol stool form types 1 or 2 more than 25% of the times. \[8\]. among patients presenting with cc, indian studies have reported fc to be commoner than ibs-c \[9, 10-12\]. high-resolution (hr-) anorectal manometry has significant diagnostic value in the assessment of anorectal disorders \[13\] this study aimed to compare the clinical and anorectal manometry profile of patients with fc and constipation-predominant irritable bowel syndrome

Eligibility criteria:
inclusion criteria: 1. age between 18- 60 years old . 2. patients fulfill rome iv criteria of chronic constipation. exclusion criteria: * patient with secondary causes of constipation :- 1. thyroid disease 2. acute or chronic kidney disease 3. acute or chronic liver disease. 4. malignancy 5 -medication 6 -uncontrolled diabetes mellitus 7 -inflammatory bowel diseases
splenic artery ligation and portocaval shunt in small-for-size syndrome

Conditions: Small-For-Size Liver Syndrome; Ligation; Liver Regeneration; Splenic Artery; Portal Vein; Ischemia; Reperfusion Injury; Hepatectomy

Summary: our study aimed at assessing the changes of portal vein pressure, portal vein flow and hepatic arterial flow (haf) in liver remnants ≤ 30% of the standard liver volume by reducing portal vein overflow via ligation of the splenic artery.

it has been reported that prevention of acute portal overpressure in small-for-size liver grafts leads to better postoperative outcomes. accordingly, we aimed to investigate the feasibility of the technique of splenic artery ligation in a case series of patients subjected to major liver resections with evidence of small-for-size syndrome and whether the maneuver results in reduction of portal venous pressure and flow.

Eligibility criteria:
inclusion criteria: * adult patients * american society of anesthesiologists (asa) distribution i to iii * patients scheduled for major liver resection (≥4 segments) exclusion criteria: * patients with extrahepatic disease * patients with metastatic liver tumors

Keywords: small-for-size liver syndrome ligation splenic artery hepatectomy liver regeneration