Kornimate/medical-research-clean huggingface dataset:
the effect of curcumin against colistin-induced nephrotoxicity

Conditions: Acute Kidney Injury; Drug-Induced Nephropathy

Summary: the goal of this study is to investigate the possible nephroprotective effect of curcumin in critically ill patients receiving colistin.

the study will investigate the possible nephroprotective effect of curcumin when added to patients infected by mdr gram-negative bacteria and require intravenous colistin therapy, curcumin will be given concurrently with colistin and discontinued at the same time as colistin.

Eligibility criteria:
inclusion criteria: * all critically ill adult patients (18-65 years old) who are infected by mdr gram-negative bacteria and require intravenous colistin therapy exclusion criteria: * patients receiving intravenous colistin therapy for \< 72 hours. * patients receiving renal replacement therapy (rrt). * patients with diseases that may contribute to renal impairment such as systemic lupus erythematosus, acute myocardial infarction, cancer, hiv infection, glucose-6-phosphate-dehydrogenase deficiency, or urinary tract stone. * pregnancy or breastfeeding. * known allergy to the study medications. * patients with chronic kidney diseases (creatinine clearance \< 60 mg/dl). * elevated total liver enzymes (ast, and alt) three times above the upper limit of normal. * patients with acute decompensated heart failure signs and symptoms requiring intravenous loop diuretics and/or intravenous inotropes and/or ace inhibitors. * uncontrolled diabetes (glycosylated hemoglobin (hb a1c) \>8%). * hypotensive patients defined as decrease in blood pressure less than 90/60 mm hg. * recent use of vitamins with antioxidant properties such as beta carotene, vitamin e, vitamin c, selenium, or n-acetylcysteine or any other medications known to have nephroprotective activities. * patients receiving other nephrotoxic drugs at enrollment (e.g., aminoglycosides, vancomycin, or amphotericin b) or administration of contrast medium within 7 days.
safety, tolerability and pharmacokinetics of bibw 2948 bs for handihaler® in healthy male volunteers

Conditions: Healthy

Summary: to investigate safety, tolerability, and pharmacokinetics of bibw 2948 bs after repeated dosing


Eligibility criteria:
inclusion criteria: * healthy males based on a complete medical history, including the physical examination, vital signs (bp, pr), 12-lead ecg, clinical laboratory tests * age ≥21 and age ≤ 50 years * bmi (body mass index) ≥18.5 and bmi ≤ 29.9 kg/m2 * signed and dated written informed consent prior to admission to the study in accordance with good clinical practice (gcp) and the local legislation * subjects must be current smokers (\ 1 year exclusion criteria: * any finding of the medical examination (including bp, pr and ecg) deviating from normal and of clinical relevance * any evidence of a clinically relevant concomitant disease * gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders * history of relevant orthostatic hypotension, fainting spells or blackouts * chronic or relevant acute infections * history of relevant allergy/hypersensitivity (including allergy to the drug or its excipients) * intake of drugs with a long half-life (\>24 hours) within at least one month or less than 10 half-lives of the respective drug prior to administration or during the trial * use of drugs which may have reasonably influenced the results of the trial based on the knowledge at the time of protocol preparation within 10 days prior to administration or during the trial * participation in another trial with an investigational drug within two months prior to administration or during the trial * smoker (\>10 cigarettes or \>3 cigars or \>3 pipes/day) * inability to refrain from smoking on trial days * alcohol abuse (more than 60 g/day) * drug abuse * blood donation (more than 100 ml within four weeks prior to administration or during the trial) * excessive physical activities (within one week prior to administration or during the trial) * any laboratory value outside the reference range that is of clinical relevance * inability to comply with dietary regimen of study centre
clinical response of syrup hydryllin® in pakistani subjects with cough in routine practice

Conditions: Cough

Summary: a cough is one of the most common medical complaints accounting for as many as 30 million clinical visits per year. it is the single most prevalent symptom on presentation to a physician's office. up to 40% of these complaints result in a referral to a pulmonologist. although, the cough is an essential defense mechanism, still, chronic cough may cause significant morbidity and substantially affect the quality of life and psychosocial wellbeing.

globally, the prevalence of acute cough is 9 to 64%, whereas chronic cough is \>10% in most countries or regions, ranging from 7.2%-33%. in pakistan, a few studies have examined chronic cough resulting from specific occupations, such as those involving brick kilns, textile work, or gem cutting. additionally, 15.8% of subjects in a periurban area of karachi city, pakistan with cough lasting ≥ 2 weeks were found to have pulmonary tb. overall, to estimate the prevalence and incidence of different coughs, there is no data available based on the local population, and the data assessing the quality of life of patients with different coughs is not available. locally, few studies were conducted on cough syrups with a small sample size. however, no real data is available for the symptomatic management of cough about the patient's quality of life related to different coughs. the current study is designed to assess the response of different strengths of syrup hydryllin ( syrup hydryllin \& hydryllin sugar-free (diphenhydramine, ammonium chloride, menthol, aminophylline) and syrup hydryllin dm (dextromethorphan \& diphenhydramine) in the symptomatic management of cough in routine practice by physicians. the study's main objective is to assess the quality of life of the subjects suffering from the different types of cough.

Eligibility criteria:
inclusion criteria: * patient with a clinical history of cough. * patients aged ≥12 and ≤70 years inclusive of either sex. * the patient will be screened for covid-19 * the patient will be prescribed the study drug following an approved package insert * written informed consent before participation in study-specific procedures exclusion criteria: * known hypersensitivity to hydryllin product, the metabolites, or formulation excipients. * covid patients with moderate and severe condition requires hospitalization or/and associated with the complications. * patients who have a contra-indication (refer to the syrup hydryllin prescribing information). * pregnant (assessed on lmp) * breastfeeding women (assessed on interview).

Keywords: cough management, cough syrup, quality of life
effectiveness of early parent-based language intervention

Conditions: Language Delay; Developmental Language Disorders

Summary: the purpose of the study is to examine the effectiveness of a highly-structured parent-based language intervention group program for two-year-old children with language delay.

language delay in toddlers is a prevalent problem for pediatric practitioners. as there are no clear guidelines to deal with this problem, in german speaking countries the "wait-and-see"approach is widely chosen, although longitudinal studies have found that children with language delay are at risc for cognitive, behavioral and social-emotional problems. during the last few years various forms of early language intervention have been increasingly implemented in german speaking countries. however, they have not been evaluated. early parent-based intervention could be an economical way in prevention speech and language disorders.

Eligibility criteria:
inclusion criteria: * children with receptive and/or expressive language abilities below norm range measured by the standardized and norm-referenced german developmental language test setk-2 (grimm, 2000) exclusion criteria: * children with visual impairments, genetic syndromes, metabolic diseases * children with previous language intervention

Keywords: language delay speech and language disorders early language intervention parent-based language intervention
inspired helium for ischemic protection during knee replacement surgery

Conditions: Ischemia

Summary: the purpose of this study is to determine whether breathing in helium reduces indications of injury to the skeletal muscle seen in blood tests after knee replacement surgery. the ability to reduce the risk of skeletal muscle injury may help improve patient safety by providing protection to the area of the body having its blood supply interrupted during a particular surgery.

during hospitalization, beginning the day after surgery, additional tests will be added to the daily standard of care blood samples. when daily blood samples are not ordered as part of a study participants care after surgery, blood samples only for the study tests, may be done. up to 60 study participants will be selected to be in one of two possible groups. after hospital discharge the study participants physical therapist will be contacted for copies of the notes and reports about the participants progress in physical therapy. this information will be used to evaluate if the different breathing gases have any impact on how quickly people recover after surgery.

Eligibility criteria:
inclusion criteria: * scheduled for an elective total knee arthroplasty * \> 18 years of age * expected to require inhaled oxygen concentrations \< 25% * able to provide informed consent exclusion criteria: * expected to require inhaled oxygen concentrations \> 25% * \< 18 years of age * member of a defined vulnerable population (e.g. pregnant, mentally handicapped, prisoners, etc.).

Keywords: ischemic preconditioning human limb ischemia total knee arthroplasty supplemental inspired helium
a pharmaceopidemiological study in patients who use symbicort smart

Conditions: Bronchial Asthma

Summary: to investigate how common it is that patients using symibort smart take high average daily doses that are not considered appropriate by their physician (overuse) or are hospitalised due to their asthma at least partly due to underuse.


Eligibility criteria:
inclusion criteria: * asthma diagnosis, patient registered with the prescribing physician for at least one year before the qualifying prescription of symbicort, prescription of symbicort smart after uk launch of the concept exclusion criteria: * none

Keywords: pharmaceopidemiological symbicort smart gprd
ligation of intersphincteric fistula tract (lift) procedure versus use of an anal fistula plug for anal fistula repair

Conditions: Anal Fistula

Summary: anal fistulae are a difficult problem to treat. the optimal treatment for fistula involving the anal sphincter is unclear. two standardly used methods of treatment are the ligation of intersphincteric fistula track (lift) procedure and the use of an anal fistula plug. the purpose of this study is to exam the rate of fistula closure between the lift procedure and the use of a fistula plug


Eligibility criteria:
inclusion criteria: * male or female subjects 18 years of age or older. * able to understand and provide informed consent or have a legally authorized representative capable of providing consent. * has a documented diagnosis, confirmed by physical exam and/or endorectal ultrasound (if available), of a trans-sphincteric fistula tract determined to be of cryptoglandular origin (primary or recurrent). exclusion criteria: * history or suspicion of inflammatory bowel disease (crohn's or ulcerative colitis). * history of connective tissue disease. * rectovaginal fistula. * presence of horseshoe fistula. * history of immunosuppression therapy/treatment within previous six months. * presents of a proximal diversion and refractory fistula. * any physical conditions, disease, or disorder that would exclude subject from being a candidate for elective surgery. * known history of allergy to pork or pork products.

Keywords: transsphincteric anal fistula cryptoglandular origin anal fistula repair ligation of intersphincteric fistula track (lift) procedure anal fistula plug (plug) surgical repair
"cancersensor" chemotherapy

Conditions: Metastatic Colorectal Cancer

Summary: observational, non randomized study aimed at measuring the effect of chemotherapy in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer.


Eligibility criteria:
inclusion criteria: * histologically-confirmed metastatic colorectal cancer; * 0 to 3 prior chemotherapy lines; * signed informed consent; * good understanding of the protocol and of the follow-up; * estimated life expectancy exceeding 3 months; * at least one measurable metastatic lesion (recist criteria); * performance status (who) of 0 to 2; * good haematological, hepatic and renal functions. exclusion criteria: * more than 2 surgical resections of metastases from colorectal cancer; * poor performance status (\>2); * poor haematological, hepatic or renal functions; * uncontrolled chronic disease; * serious unhealed wound, ulcer or fracture within the previous month; * clinical or laboratory finding suggesting possible abnormalities in nucleosides urinary excretion; * pregnancy or breast-feeding during the previous month; * transmeridian trip of more than 4 time zones within the prior 2 weeks; * person with legal restriction to participate into clinical research, according to the current law in france.

Keywords: colorectal cancer metastatic chronotherapy urine nucleosides chemotherapy treated with chemotherapy
efficacy of combination immunotherapy in patients with metastatic colorectal cancer

Conditions: Colorectal Cancer

Summary: immunotherapy improved efficacy and survival in selective patients with metastatic colorectal cancer (mcrc), however, limited data revealed the landscape of immunotherapy efficacy. what's more, potential markers have not been comprehensively evaluated to identify responding patients to further improve efficacy.the investigators conducted a single-arm study to investigate the efficacy of combination immunotherapy in patients with mcrc, and the combined regimen is determined by the physician in charge.


Eligibility criteria:
inclusion criteria: * patients who had both baseline measurable lesion(s) and at least one post-baseline radiological disease reassessment * patients with identified genomic status exclusion criteria: * patients who received immune monotherapy * patients who stopped treatment for any reason without identified response assessment.
telerehabilitation for hip and knee osteoarthritis

Conditions: Osteoarthritis, Knee; Osteoarthritis, Hip

Summary: digital health utilization in the form of telerehabilitation is a popular technology that is very little researched for musculoskeletal disorders particularly hip and knee osteoarthritis (oa). the progression of oa will lead to total hip or knee replacement surgery. as a consequence, the advancing aging population leads to an increased burden on the healthcare system due to rising osteoarthritis. that's why, we will conduct a randomized controlled trial to explore the effectiveness of telerehabilitation in hip and knee osteoarthritis. this study will recruit oa patients into control and experimental groups. the control group will receive a patient education while the experimental group will undergo remote exercise sessions. both groups will receive one supervised session a week for 5 weeks. the pre- and post-outcome measures will be recorded for functional status of hip and knee, muscle strength, and range of motions of the lower extremity. this innovative study will evaluate the effectiveness of a telemedicine intervention applied to a clinical population in taiwan. the use of telerehabilitation interventions aims to reduce treatment and transportation costs, as well as save time for patients with oa. this digital health approach also helps to alleviate the workload of physiotherapists and rehabilitation doctors in clinics. the findings from this study could broaden the scope for using remote digital technology to assist clinical patients in diverse settings, especially those with limited or no hospital access.

purpose: to conduct a randomized controlled trial to explore the efficacy of telerehabilitation intervention for 5 weeks in a clinical population with hip and knee osteoarthritis.

Eligibility criteria:
inclusion criteria: 1. diagnosed with hip or knee osteoarthritis within last one year 2. having sub-acute or chronic symptoms of pain and functional disability 3. living in an area served by high-speed internet services (at least 512 kb/s in upload) 4. living within an hour driving distance from the treating hospital 5. physically fit to provide a written consent to participate in this study exclusion criteria: 1. taking sedatives, autoimmune, or other medication that can interfere with their exercise program 2. any health issues that could affect the tests or the rehabilitation program, including surgery over the recent six months 3. having diagnosed with cognitive disorders 4. having recent surgery or major postoperative complications

Keywords: telerehabilitation osteoarthritis randomized controlled trial
pfo occlusion and atrial fibrillation

Conditions: Atrial Fibrillation New Onset; Embolic Stroke of Undetermined Source; Patent Foramen Ovale

Summary: interventional closure of patent foramen ovale (pfo) associates with reduced risk of stroke recurrence in patients with cryptogenic ischemic stroke as reported in the recent close and reduce trials. the long-term follow-up results of the respect and defense-pfo trial confirmed these findings. pfo closure is therefore recommended in patient with cryptogenic ischemic stroke and pfo according to the current german interdisciplinary guidelines. it is likely that the number of pfo closure procedures will increase significantly in the near future. however, new onset atrial fibrillation (af) appears to increase in patients following this procedure. in the reduce study, new onset atrial fibrillation was detected in 6.6% patients in the pfo closure group compared with 0.4% in the control group (medical treatment); 59% of these patients were diagnosed within the first two weeks following the procedure and 83% within 45 days, respectively. these results were consistent with the close study: af was detected in 4.6% patients in the intervention group vs. 0.9% in the control group. up until today, markers to identify and quantify the individual risk of af onset are lacking. furthermore, under-reporting and under-detection of af occurrence after pfo closure is likely. this study is designed to to assess the prevalence and and identification of electrophysiological and echocardiographic parameters of new-onset af.


Eligibility criteria:
inclusion criteria: * previous embolic stroke with undetermined source with... * palpitations with clinical indication for an electrophysiological study (control group) * pfo and clinical indication for interventional pfo closure according to current guidelines (intervention group) * sinus rhythm at time of inclusion with no history of af * planned ep study due to reported palpitations or documented burden of non-sustained atrial arrythymias (\>100 atrial ectopic beats /24 hours, atrial tachycardia) * written informed consent exclusion criteria: * previously documented af * indication for therapeutic anticoagulation * uncontrolled diabetes mellitus * acute coronary syndrom or acute cardiac decompensation within the last 6 months before enrollment * enrolled in another study * bmi \> 40 kg/m² * patients who are pregnant of breastfeeding life expectancy \< 6 months * relevant peripheral artery disease * substance abuse
cereals as a source of iron for breastfed infants

Conditions: Iron Deficiency

Summary: the purpose of this research study is to determine whether the type of iron in infant cereals makes a differance in how well the cereal helps infants remain free of iron deficiency.


Eligibility criteria:
inclusion criteria: * exclusively breastfed * birth weight between 2500 and 4200g * gestational age \>36 weeks exclusion criteria: * supplementing formula * no iron drops
resistance training in adults with obesity

Conditions: Overweight and Obesity

Summary: the purpose of this project is two-fold: (1) to assess if two different resistance training protocols elicit different responses in the acute phase and (2) to assess if the same two different protocols will elicit different long-term responses on muscular strength, body composition and cardiometabolic health. the project will include 30 adults with obesity (defined as bmi ≥ 30 or abdominal obesity according to the international diabetes federation). in the acute phase blood lactate, heart rate, enjoyment and perceived exertion will be assessed after the two resistance training protocols. in addition, the mean 24-h blood glucose concentration after exercise will be compared between the two protocols. for the long-term effects blood markers of cardiometabolic health, blood pressure, body composition, objectively measured physical activity and physical fitness will be assessed before and after the intervention. also, perceived health-related quality of life will be assessed before and after the intervention.


Eligibility criteria:
inclusion criteria: * obesity (bmi ≥ 30) or * central obesity (defined according to the international diabetes federation). exclusion criteria: * unstable angina * recent cardiac infarction (last 4 weeks) * uncompensated heart failure * severe valvular illness * pulmonary disease * uncontrolled hypertension * kidney failure * orthopaedic/neurological limitations * cardiomyopathy * planned operations during the research period * participation in a parallel study

Keywords: exercise therapy muscular strength resistance training fitness testing healthy lifestyle