Kornimate/medical-research-clean huggingface dataset:
body composition after laparoscopic gastrectomy for gastric cancer

Conditions: Gastric Cancer; Benign Gastric Tumor

Summary: nutritional status including changes of body composition is one of the most important clinical determinants of outcome after gastrectomy for gastric cancer. various type of gastric operations are widely used with favorable outcome in south korea. it was reported that several advantages of laparoscopic gastrectomy are the prevention of overt weight loss and enhanced recovery of muscle mass at 6 months after surgery. but there have been no longitudinal studies evaluating changes in the body composition according to the different type of anastomosis of laparoscopic gastrectomy. the purpose of this prospective study was to investigate changes in lipid indices associated with whole body composition during 1 year of follow-up after laparoscopic gastrectomy. gastrectomy resulted in improved lipid indices and a reduction in body weight, fat and lbm. the hdl-csignificantly increased in the non-obese group for 1 year after gastrectomy and the reduction of tg level was positively correlated with fat, especially with trunk fat.

* all patients will undergo a laparoscopic gastrectomy for their gastric cancer (proved to be stage i or ii) or benign gastric neoplasm by preoperative screening diagnostic procedure. they will receive laparoscopic gastrectomy as follows: (1) wedge resection, subtotal or total gastrectomy with or without lymph node dissection; (2) r0 resection; (3) laparoscopic gastrectomy; (4 gastroduodenal anastomosis or duodenal bypass, including roux-en-y or gastrojejunostomy. * pre-operative, 6 and 12 months post-operative body composition measurement will be performed on each patient. the whole body composition measurement will be assessed by hologic 4500/a dual energy x-ray absorptiometry system. the software performs calculations of the differential attenuations of the two photon energies and present data of percentage of fat, fat mass (g), lean mass (g), bone mineral content (g), bone mineral density (g/cm2), and total mass (g). * laboratory analysis - there is a battery of labs that are ordered in both the pre-operative, 6 and 12 months post-operative time frame. these labs are ordered independent of the patient's participation in the study. these labs are ordered to evaluate and to assist management of the patient's medical comorbidities as well as to assess for adequate nutritional intake and balance. * queries on nutritional intake and exercise will be made at each post-operative appointment.

Eligibility criteria:
inclusion criteria: * patient with gastric cancer or benign gastric neoplasm planning gastric operation * stage i and ii patients by preoperative screening exclusion criteria: * distant metastasis * severe comorbidity * malnourished state * inability of access to enteral feeding

Keywords: body composition measurement lipid profile weight loss gastrectomy
safety and efficacy of lastacaft® for the prevention of itching associated with allergic conjunctivitis in korea

Conditions: Conjunctivitis, Allergic

Summary: this post-marketing surveillance study will assess the safety and efficacy of lastacaft® opthalmic solution 0.25% (alcaftadine) for the prevention of itching associated with allergic conjunctivitis as prescribed as standard of care in clinical practice in korea.


Eligibility criteria:
inclusion criteria: -patients with itching associated with allergic conjunctivitis. exclusion criteria: -patients with hypersensitivity to lastacaft® or its components.
effectivness of tramadol or topic lidocaine on postoperative analgesia in laparoscopic colorectal resection.

Conditions: Postoperative Pain

Summary: comparison of different postoperative analgesia after laparoscopic colorectal surgery

postoperative pain treatment should be multimodal and opioid sparing. thoracic epidural analgesia could relieve pain after laparoscopic surgery. although eras guidelines suggest to use less invasive pain relieve technique, opioids are widely used perioperatively, despite of their side effects. non-opioids and 5% lidocaine patches, used topicaly, could effectively reduce opioid consumption and their side effects. namely, efficient perioperative pain treatment is important to prevent late neuropathic pain, also after laparoscopic lower abdominal surgery. its incidence is usually low compared to open surgery. the aim of present study was to evaluate, if opioid consumption in laparoscopic colorectal surgery could be reduced with lidocaine patch at the wound site or with infusion of metamizole and tramadol and if the results meets epidural analgesia. we also compared the incidence of postoperative neuropathic pain among groups. prospective, randomised trial with 4 parallel groups was conducted at the university medical centre (umc) ljubljana. asa (american society of anaesthesiologists) class 2-3 high risk surgical patients from the clinical department of abdominal surgery were included in the study. adult patients that underwent laparoscopic colorectal surgery were included.

Eligibility criteria:
inclusion criteria: * scheduled elective laparoscopic colorectal surgery exclusion criteria: * critical preoperative state, pregnant women, laparotomy and palliative procedures.

Keywords: postoperative analgesia neuropathic pain laparoscopic colorectal surgery
therapeutic education using an internet application in hereditary ichthyosis

Conditions: Ichthyosis

Summary: the main purpose is to evaluate the feasibility (global use) of a therapeutic patient education program using a specific web application in patients with hereditary ichthyosis.


Eligibility criteria:
inclusion criteria: * patient with hereditary ichthyosis, according to the classification established during the 2009 consensus conference * who has given his informed consent form * who is affiliated to a social security system exclusion criteria: * patient who has already participated in a therapeutic patient education program for the hereditary ichthyosis * unable to connect or use a computer tool * impossibility to be present at the only face-to-face session * patient who is not available for the collective educational session * patient with little or no motivation to follow a therapeutic patient education program (motivation evaluated by the educational team by phone call before inclusion) * patient not mastering the french language * person under legal protection (guardianship, curators or safeguard of justice)

Keywords: hereditary ichthyosis
impact of posterior nasal neurectomy with functional endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis:a comparative study

Conditions: Nasal Polyps

Summary: the study will be conducted to investigate the efficacy of posterior nasal neurectomy in control of recurrence and improvment of allergic symptoms in patients with allergic rhinitis combined with nasal polyposis

allergic rhinitis patients with nasal polyposis will go through fess combined with posterior nasal neurectomy to detect recurrence rate

Eligibility criteria:
inclusion criteria: * all cases presented to ent department assuit university with allergic rhinosinusitis with nasal polyposis exclusion criteria: * refusing enrollment into the study. pregnant women refusing surgery containdication to surgery patients with aspirin syndrome
hemodynamic determinants of urine output during spinal anesthesia

Conditions: Urine Output Decreased

Summary: this clinical trial investigates the relationship between urine output and mean arterial pressure (map) during spinal anesthesia. the study aims to validate observations from animal models in humans by concurrently measuring hemoglobin levels, map, and urine output, focusing on the effects of ringer's solution, to provide crucial insights into optimal fluid management during anesthesia with minimal complexity.

the proposed clinical trial aims to explore the relationship between urine output and mean arterial pressure (map) during spinal anesthesia, a subject that has not been thoroughly studied in humans despite previous research under general anesthesia. studies have demonstrated that the diuretic response to intravenous volume loading, using ringer's solution or 20% albumin, varies with map levels. specifically, ringer's solution shows a greater diuretic effect when map exceeds 70 mmhg, whereas 20% albumin is more effective at lower pressures. this differential response highlights the importance of considering map in the choice of fluid for managing hypovolemia and oliguria. the study's relevance is highlighted by the physiological dynamics at play, particularly how high levels of anesthesia, which influence the sympathetic nervous system from the mid-thoracic region, might reduce map and consequently decrease urine output. while this hypothesis has been examined in animal studies, its validity in humans remains unconfirmed. to address this, the trial will measure hemoglobin levels, map, and urine output simultaneously, aiming to establish a clear correlation among these variables during spinal anesthesia. this methodical approach seeks to yield significant insights with minimal additional effort, contrasting with the complexities inherent in more elaborate study designs.

Eligibility criteria:
inclusion criteria: * written informed consent provided by patients or their legally authorized representatives. * adults aged 18 years and older. exclusion criteria: * contraindications to spinal anesthesia: * patient refusal * presence of coagulopathy. * current use of anticoagulant or antiplatelet medications. * critical or severe aortic stenosis or other fixed cardiac output states. * high risk of infection at the spinal needle insertion site. * elevated intracranial pressure. * allergy * sepsis * procedures not amenable to spinal anesthesia: * planned concurrent procedures that cannot be performed under spinal anesthesia.

Keywords: urine output spinal anesthesia mean arterial pressure
af stroke substudy sl-ecg versus 12lead ecg

Conditions: ECG; Atrial Fibrillation; ECG Hand-held Diagnostic Tool

Summary: the purpose of the study is to compare parameters obtained per sl-ecg with the values from 12lead-ecg measurement. patients who undergo out- or inpatient treatment and who receive a 12lead-ecg are asked to participate in this examination. furthermore, 50 patients without heart disease should be included (control group).

atrial fibrillation is the most common cardiac arrhythmia in germany. clinical studies have shown that atrial fibrillation is associated with increased morbidity and mortality and reduced quality of life. patients with atrial fibrillation have a three times higher risk of heart failure and a four to five times higher risk of ischemic stroke. in addition to these risks, atrial fibrillation is often asymptomatic and therefore more difficult to diagnose. it is estimated that about one third of all atrial fibrillation patients are asymptomatic. for this reason, the study "opportunistic screening in pharmacies for atrial fibrillation in seniors" was conducted in aachen. within four weeks more than 7000 volunteers could be measured in participating pharmacies using a ecg hand-held diagnostic tool. since the already measured subjects only have the sl-ecg measurement of the hand-held diagnostic tool, the aim of this substudy is to establish a reference group. in this reference group a 12lead-ecg is performed by routine ecg and a sl-ecg measurement by ecg hand-held diagnostic tool. the aim of the study is to compare the measured parameters and to optimize the algorithm to evaluate the remaining sl-ecgs of the main study.

Eligibility criteria:
inclusion criteria: * patient is 18 years old, for minors the signature of the legal guardian is required. * understanding of the essence, meaning and scope of the study. * patients (in-/outpatient) who receive a 12lead ecg through medical clinic 1. * volunteers who are willing to have a 12lead ecg and an sl-ecg performed and provide medical information. * signed informed consent exclusion criteria: * insufficient language skills * limited cognitive abilities * limited physical abilities (i.e. tremor)

Keywords: ecg measurement af-stroke germany electrocardiogram
evaluation of communication functions in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: in this study, investigators aimed to evaluate the communication functions of children between 2-18 with cerebral palsy. investigators planned to investigate the relationship between communication skills and clinical characteristics and socio-demographic status of the family.

cerebral palsy (cp) is a non-progressive, movement-limiting loss of permanent motor function, posture and movement disturbance in the developing brain due to lesion or injury that occurs during the intrauterine period or in the first months of life. secondary medical problems such as epilepsy, mental retardation, behavior disorder, swallowing problems and musculoskeletal disorders may be seen in these patients. neuroanatomical problems in the muscles associated with the mouth and speech, and the presence of central pathologies, are important problems in patients with cerebral palsy. monitoring the communication level of these patients is very important for determining treatment protocols and monitoring their effectiveness. difficulties in communication significantly affect the rate and level of recovery in patients with cerebral palsy. there are many different scales to analyze communication level and problems in children with cerebral palsy. the most commonly used ones are the communication function classification system (cfcs) and the functional communication classification system (fccs). by examining the communication level in 5 categories in both scales, it helps to monitor the communicative development of the child and also provides a common language among clinicians. they are defined by the world health organization (who) and focus on the levels of activity and participation defined in the international classification of function, disability and health. the aim of this study was to evaluate the communication level in children over 2 years of age with cerebral palsy. in addition, the relationship between communication skills and general functional levels and demographic characteristics will be investigated. in this way, both the general communication level of this patient group and the possible factors affecting this skill will be analyzed. thus, these relationships and measurements can be utilized in determining treatment and rehabilitation protocols.

Eligibility criteria:
inclusion criteria: * patients whose parents agreed to participate in the study. * patients with confirmed cerebral palsy. * patients aged 2-18 years. exclusion criteria: * patients without definite cerebral palsy. * patients whose family refused to participate in the study. * patients with another neurological disorder that may affect their physical and neurological capacity.

Keywords: cerebral palsy communication
a study to evaluate the effects of ono-2506 intravenous infusion in patients with acute ischemic stroke

Conditions: Cerebrovascular Accident

Summary: the primary objective of this study is to compare the efficacy of ono-2506 versus placebo in neurological stroke outcome in patients with acute ischemic stroke.


Eligibility criteria:
inclusion criteria: * patient must have a clinical diagnosis of acute cortical ischemic stroke. * patient must be randomized into the study within six hours after the initial onset of stroke symptoms. * patient must have a measurable focal neurological deficit for a minimum duration of 60 minutes. * patient must have a ct or mri examination compatible with the clinical diagnosis of acute ischemic stroke. * patient must have had a pre-stroke mrs scale score of 0 or 1. * other inclusion criteria as specified in the study protocol. exclusion criteria: * patient must not have a body weight of more than 125 kg. * patient must not have a ct and/or mri with evidence of a non-ischemic mechanism, subarachnoid hemorrhage, or primary intracerebral and/or intraventricular hemorrhage. * patient must not have all three of the following findings: 1. reduced level of consciousness (has score of greater than or equal to two on nihss question 1a) 2. forced eye deviation or total gaze paresis (has score of 2 on nihss question 2) and 3. dense hemiplegia (no movement) of upper and lower extremities (i.e., has score of 4 on nihss question 5 regarding motor arm and has score of 4 on nihss question 6 regarding motor leg). * patient must not have neurological signs and symptoms that are rapidly improving. * patient must not have a severe coexisting or terminal systemic disease. * patient must not be pregnant or lactating. * patient must not have impaired hepatic function; bilirubin greater than 2 mg/dl and or ascites. * patient must not have impaired renal function; serum creatinine greater than 2 mg/dl. * patient must not have congestive heart failure. * patient must not have a baseline ecg showing a pr interval greater than 200 milliseconds, or a corrected qt interval of greater than 480 milliseconds, or a history of ventricular arrhythmias, or a mobitz type 1 or greater av block. * patient must not have other exclusion criteria as specified in the study protocol.

Keywords: acute ischemic stroke
multiple dose dental pain study of ibuprofen extended release

Conditions: Pain

Summary: the study hypothesis is that single and multiple doses of ibuprofen 600 mg er caplets provide analgesic efficacy superior to placebo over 12-hour dosing intervals.


Eligibility criteria:
inclusion criteria: * males and females 16 to 40 years of age * subjects who undergo surgical removal of at least two third molars * one of which must be a partial or full bony mandibular impaction * subjects must have at least moderate baseline pain (a score of 2 on the categorical pain severity rating scale) confirmed by a score of at least 50 mm on the 100-mm visual analog scale-pain severity rating scale (vas-psr) exclusion criteria: * acute localized dental infection at the time of surgery that could confound the post-surgical evaluation * presence or history of any significant organ disease * use of prescription or otc first generation antihistamines * females who are pregnant, lactating or of childbearing potential and not using a medically approved method to prevent pregnancy

Keywords: dental pain multiple dose ibuprofen third molar extraction
stuttering and apraxia of speech: the efficacy of an intervention program

Conditions: Stuttering; Developmental Apraxia of Speech

Summary: subjects' utterances were submitted to acoustic analysis before and after the intervention program applied on prosodic basis.

the study has the aim of developing knowledge, methodology and technique in the prosody area, for its application on the speech therapy, with the assistance of a feedback system - with winpitchpro (philippe martin). a database was constituted on the basis of a patterned corpus (eurom1) by its translation, recording and editing on .wav format. throughout model-sentences, an experimental intervention program initiates with the participation of 2 adults with stuttering problem and 2 with apraxia of speech. the efficacy of the therapeutic procedure is tested on the basis of the acoustical and the statistical analyses which have compared the first and the second speech samples taken before and after the twenty (20) therapy sessions held in a prosody approach only.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of stuttering * clinical diagnosis of apraxia of speech * 18 years of age or older * portuguese native language * agreement by the participant to enroll on 20 therapy sessions scheduled in a 3 month period exclusion criteria: * history of major medical illness unrelated to primary diagnosis of developmental stuttering and developmental apraxia of speech * significant abnormalities on general physical and neurological examination unrelated to primary diagnosis

Keywords: stuttering apraxia of speech motor control prosody pitch range speech rate fluency disorders
vessel wall response of the zotarolimus drug-eluting stent implanted in ami assessed by optical coherence tomography

Conditions: Acute Myocardial Infarction

Summary: the objective of this study is to evaluate the completeness of struts coverage and vessel wall response (strut malapposition, neointima disomogeneities in texture) to the endeavor drug-eluting stent vs the driver stent (bare metal stent of identical metallic platform) implanted for the treatment of the culprit lesion in st-elevation acute myocardial infarction (stemi). to investigate the completeness of the coverage as well as the number of uncovered stent struts per section (embedded, uncovered, malapposed) and the neointima texture, high resolution (\~ 10-15 µm axial) intracoronary optical coherence tomography (oct)will be used.

major concerns have been raised with regard to the safety of drug-eluting stents (des) in patients with st-elevation acute myocardial infarction (stemi). data from registry studies have suggested that implantation of des during primary pci could be associated with an increased risk for stent thrombosis, probably due to delayed arterial healing. unlike first generation des, zotarolimus-eluting stents seems to be associated with complete and uniform neointimal coverage. the objective of this prospective study is to measure the completeness of strut coverage and vessel wall response to the endeavor zotarolimus-eluting stent vs the driver stent (bare metal stent of identical metallic platform) implanted in stemi patients. optical coherence tomography (oct) that detects smaller degrees of stent strut coverage more accurately than ivus will be used at 6 months follow-up. intravascular ultrasound (ivus) will be performed as per normal practice at any index procedures and at 6 months follow-up.

Eligibility criteria:
inclusion criteria: * acute myocardial mi with st segment elevation, within 12 hours from symptoms onset * native coronary artery disease with \>70% diameter stenosis (no prior stent implant, no prior brachytherapy) * vessel size in between 2.5 and 3.75 mm * signed patient informed consent exclusion criteria: * lesions in coronary artery bypass grafts * significant left main disease * killip class iv * reecent major bleeding (6 months) * renal failure with creatinine value \> 2.5 mg/dl * allergy to aspirin and or clopidogrel/ticlopidine * patient in anticoagulant therapy * ima due to a stent thrombosis * no suitable anatomy for oct scan: (only ostial location, very tortuous anatomy, very distal or large vessels \[≥ 3.75 mm in diameter\])

Keywords: acute myocardial infarction percutaneous coronary interventions optical coherence tomography thrombus
study mk0767 and metformin in type 2 diabetic patients (0767-020)

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of the study is to assess how mk0767, compared to metformin, performs in lowering blood glucose levels in patients whose type ii diabetes is not controlled by diet and exercise.


Eligibility criteria:
inclusion criteria: * patients are men and non-pregnant women ages 21 to 78 years * patients either not on antihyperglycemic medications (\>8 weeks), or being treated with a single oral antihyperglycemic agent \& willing to discontinue therapy for the duration of the study exclusion criteria: * patient has history of type 1 diabetes mellitus and or history of ketoacidosis * patients undergoing surgery within 30 days of visit 1 * patients taking warfin or warfin-like anticoagulants * patients on a weight loss program with on-going weight loss or starting an intensive exercise program within 4 weeks of visit 1/week 9