Kornimate/medical-research-clean huggingface dataset:
effect of trophectoderm biopsy for sex selection on the pregnancy and miscarriage rates of women undergoing ivf/icsi

Conditions: Assisted Reproduction

Summary: records of women who had trophectoderm biopsy for sex selection over the last 3 years will be reviewed and its outcome will be compared to other records of women who had ivf/icsi without embryo biopsy.

records of women who had trophectoderm biopsy for sex selection over the last 3 years will be reviewed. women will be divided into 3 groups: group 1 will comprise fertile women who had embryo biopsy for sex selection/family balancing, group 2 will comprise infertile women who had trophectoderm biopsy and group 3 will comprise infertile women who had ivf/icsi without embryo biopsy. the pregnancy and miscarriage rates of the groups will be compared. before starting the embryo biopsy process couples were seen by a geneticist to assess the feasibility of the procedure for each couple. couples were then counselled by a gynaecologist specialised in ivf to assess their fertility status and explain the whole procedure including the expected success rates and risks of ivf. women had standard pituitary down-regulation with gnrha (triptorelin 0.1mg, decapeptyl® ferring, germany) day 7 after ovulation of previous cycle or on day 21 of the oral contraceptive cycles. gnrha was continued for 2 weeks. human menopausal gonadotrophin(hmg) (merional ®ibsa) 150-300 iu/day was administered until the day of hcg administration, transvaginal oocyte retrieval will be performed 34-36 h after the administration of hcg. day 5 embryos were incubated in calcium/magnesium free culture. a laser beam was used to produce a hole in the zona pellucida. trophectoderm cells were collected by gentle suction using the biopsy pipette. florescent in situ hybridization of the trophectoderm nuclei with probes specific to the x- and y-chromosomes was performed. the embryos were frozen and the cycles deferred.the embryos were thawed in the following cycle and if possible 2 embryos of the desired sex were transferred.

Eligibility criteria:
inclusion criteria: * women undergoing ivf/icsi exclusion criteria: * women with expected poor ovarian response according to the bologna criteria.
assistance program for outpatients following an allogeneic hematopoietic stem-cell transplant

Conditions: Hematologic Neoplasms

Summary: after the initial monitoring period during hospitalization and isolation, patients with recent transplants are regularly monitored in monthly consultations but are still fragile, immunosuppressed and undergoing many treatments. the implementation of an outpatient assistance program for transplant patients should be feasible and allow for the improvement in medical-psycho-social care for the patients during this fragile and risky period, improve the satisfaction and quality of life for these transplant patients and assist in their socio-professional and familial reintegration.


Eligibility criteria:
inclusion criteria: * adult patients over 18 years of age * having received an allogeneic hematopoietic stem-cell transplant * in full remission * outpatients * having given their informed consent for the participation in the outpatient assistance program with a navigation nurse (ama-allo) at the first post-transplant consultation (starting on day 100 +/- 10 days post-transplant i.e., when the patient passes the initial post-transplant monitoring period in hospitalization (conventional or by day) to the monitoring period in monthly medical consultations) and continuing for 12 months * affiliated with the social security system exclusion criteria: * transplant patients not having given their informed consent for inclusion in ama-allo * hospitalized or non-outpatient transplant patients * post-transplant patients in cytological relapse * patients under a legal regime of adult protection (guardianship, curatorship, etc.)

Keywords: allogeneic hematopoietic stem-cell transplant outpatient assistance "navigation" nurse
investigative analysis of soft tissue sarcoma clinical trials: an observational study

Conditions: Soft Tissue Sarcoma

Summary: generally, specific demographic cohorts exhibit higher participation rates in medical research, yet there exists a scarcity of research elucidating the trial attributes impacting the engagement of these particular demographics. the primary objective of this study is to gather extensive data on the clinical trial experiences of individuals diagnosed with soft tissue sarcoma, with the aim of identifying factors hindering patient enrollment or trial completion.


Eligibility criteria:
inclusion criteria: * patients diagnosed with soft tissue sarcoma * aged ≥ 18 years old and ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed * subjects willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examination. exclusion criteria: * refusal of consent * women of childbearing potential without a negative pregnancy test; or women who are lactating. * any serious and/or unstable pre-existing medical disorders

Keywords: soft tissue sarcoma
covid-19 infection in patients with hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma; COVID-19

Summary: since december 2019, a new disease named covid-19 linked to a new coronavirus, sars-cov2 has emerged in china in the city of wuhan, hubei province, spreading very quickly to all 5 continents, and responsible for a pandemic. france is the third most affected country in europe after italy and spain. groups of patients at a higher risk of developing a severe form of covid-19 have been defined: this include patients with immunosuppressive disease as cancer or patients with advanced cirrhosis of the liver. coronavirus liver injury had been described with sars-cov 1 and mers-cov. there is no data on liver damage associated with covid-19 infection for compensated or decompensated cirrhotic patients. the objectives of this project are to estimate the incidence of covid-19 in hepatocellular carcinoma population, both hospital and ambulatory, and to study the impact on the frequency of severe forms, the prognosis, but also liver function, and the management of hepatocellular carcinoma, in this context of pandemic


Eligibility criteria:
inclusion criteria: * patients with chc and included in the french national prospective cohort chief * hospital and ambulatory patients * infection confirmed by covid-19 defined by a positive nasopharyngeal pcr or if pcr covid-19 negative : ct showing covid-19 compatible pneumonia * suspected covid-19 infection, not confirmed by covid-19 pcr or chest ct, with no other known cause of acute pneumonia. exclusion criteria: * patient refusal * influenza only, confirmed by a diagnostic test * other proven causes of pneumonia and absence of covid-19

Keywords: hepatocellular carcinoma covid-19 coronavirus disease 2019-incidence
improved language acquisition with levodopa

Conditions: Healthy

Summary: the purpose of this study is to determine whether the non-daily administration of levodopa is effective in boosting semantic language acquisition in healthy subjects.

our prior work using a between-subject design shows that daily administration of d-amphetamine or the dopamine precursor levodopa over the course of five days markedly improves word learning success in healthy subjects. in this randomized, placebo-controlled, double-blind clinical trial, we probe whether the effect can be replicated using a within-subject design, with administration of levodopa and placebo on alternate days for a total period of 10 days. the expected scientific results will strengthen the basis for transferring neuromodulatory interventions from the laboratory to stroke patients with language dysfunctions. because of the heterogeneity of stroke patients, only a within-subject design can be used to probe the effects of pharmacological adjuncts to language therapy.

Eligibility criteria:
inclusion criteria: * healthy subjects * 20-35 years old * right handedness exclusion criteria: * neurological/psychiatric/metabolic/cardiac disorders * asthma * known allergic reactions to one of the experimental drugs * other drugs affecting the central nervous system * leisure drug ingestion during the past 4 weeks (urine test) * smoking cessation during the past 2 weeks * \> 6 cups of coffee or energy drinks per day * \> 10 cigarettes per day * \> 50 grams of alcohol per day

Keywords: language acquisition plasticity stroke recovery associative learning
institutional audit of the use of intravenous acetaminophen in infants undergoing pyloromyotomy

Conditions: Pyloric Stenosis

Summary: this is a retrospective chart review. the objective of the current study is to determine the analgesic efficacy and side effect profile of intravenous acetaminophen when administered to infants undergoing pyloromyotomy. in addition, recovery characteristics of infants who were administered intravenous acetaminophen will be compared to infants who did not receive intravenous acetaminophen to determine if there were any appreciable differences with regard to postoperative discomfort, pacu time, time to oral feeds and hospital discharge.


Eligibility criteria:
inclusion criteria: * patients who presented for pyloromyotomy exclusion criteria: * none
aerobic exercise and cognitive training in patients with stroke

Conditions: Ischemic Stroke; Hemorrhagic Stroke

Summary: the goal of this clinical trial is to test the effects of aerobic exercise and bdnf on patients with ischemic and hemorrhagic stroke during a computerized cognitive training. the main questions it aims to answer are: 1. does a moderate intensity aerobic exercise, prior to a cognitive training, allow a better performance? 2. is it possible to exploit the timing of rehabilitation interventions to obtain greater effects? participants will be divided in 2 groups. the experimental group will first perform 20 minutes of pedaling as a moderate intensity aerobic exercise. it will then participate in one-hour cognitive training sessions, with the aim of training attentional, working memory and executive functions. the control group will carry out the same interventions but in reverse order. the researchers will compare the results of the cognitive training in the two groups to verify if the order of the interventions influences the results themselves.


Eligibility criteria:
inclusion criteria: * patients with a clinical diagnosis of stroke, both ischemic and haemorrhagic. * patients admitted to the specialist rehabilitation unit 1 of the "e. spalenza - don gnocchi "of rovato. * overall score in the moca test ³ 26 * in case of a diagnosis of aphasia, a test of verbal comprehension ("token test") with score in the norm, p.e. \> 1 * hypertonic and spasticity picture compatible with the performance of motor activity of pedaling expected in the ea session. * tolerance of physical exercise * incoming electrocardiogram normal and free of anomalies exclusion criteria: * overall score in the moca test \<26 * in case of a diagnosis of aphasia, a test of verbal comprehension ("token test") with pathological or borderline score, p.e. £ 1. * documented diagnosis of neurodegenerative diseases with impact on performance cognitive. * severe acquired brain injury * illiteracy * status of hypertonus and spasticity not compatible with the performance of motor training * excessive fatigue: the patient does not tolerate moderate intensity physical activity and accuses excessive fatigue during the preliminary test * electrocardiogram at entrance with anomalies and / or altered * ischemic heart disease * cardiac disorders that are contraindications for aerobic activity of moderate intensity

Keywords: bdnf aerobic exercise cognitive training
cardiovascular risk assessment model in patients with mi

Conditions: Myocardial Infarction, Acute

Summary: this study aims to investigate life-style and psycho social factors of major cardiovascular events in patients with myocardial infarction in three different provinces of iran and to design a risk assessment chart for major cardiovascular events in patients with mi.

patients with pre-existing mi are at higher risk of major cardiovascular events (mce). current studies mainly focus on cardiovascular disease (cvd) risk assessment in general population without a history of cvd. because of high prevalence of ischemic heart disease, especially in developing countries such as iran, this group of patients form a large high-risk population. factors such as life styles, habits, and psychosocial features are adjustable factors which have been less studied in relation to mce in mi patients worldwide. psychological factors are especially most important in patients with a pre-existing cvd and can account for worse outcomes independent of other pathological factors. the cardiovascular events are multifactorial and control of traditional risk factors such as hypertension and hyperlipidemia cannot efficiently reduce mce. identification and comprehensive assessment of mce risk factors is essential for reducing mce and thus better management of patients. the effect of different factors on mce could be analysed using risk assessment model. to the best of our knowledge, this is the first comprehensive study of life style and psychological risk factors in cvd patients and the first time to perform mce risk assessment modelling in mi patients. the predictors recorded in this study are categorized in three main issues: 1) lifestyle, including: nutritional status, physical activity, tobacco smoking and drug abuse, sleep quality, and sexual function assessed by relevant questionnaires. 2) behavioral and psychological factors, including: depression, psychological distress, health anxiety, health related quality of life, type d personality, coping strategies, sense of coherence and medication adherence also measured by appropriate questionnaires. 3) traditional risk factors, including: hypertension, diabetes, and hyperlipidemia which will be extracted from medical and laboratory records of patients and questionnaires. all predictor variables will be assessed in every year follow-up for three years during the study.

Eligibility criteria:
inclusion criteria: * clinically verified diagnosis of the first episode st-elevation myocardial infarction * providing written informed consent exclusion criteria: * history of prior documented cvd * living in a nursing home or other institutions * having a serious medical condition with a survival of less than 3 years * participation in another scientific study * not willing to participate in each phase of the study.

Keywords: myocardial infarction major cardiovascular events risk assessment
functional vision with acrysof® iq iols blue light filtration

Conditions: Cataract

Summary: the purpose of this study is to compare the reaction time (as measured by braking reaction time in seconds during simulated driving) under glare and no-glare conditions in subjects implanted with acrysof® iq intraocular lenses (iols) to subjects implanted with clear iols. this study will enroll subjects previously implanted with iols in both eyes for at least 3 months.

subjects completed 2 visits to the investigational site.

Eligibility criteria:
inclusion criteria: * pseudophakes with acrysof® iq monofocal iols or clear (no blue light filter) iols in both eyes for at least 3 months. * willing and able to understand and sign an informed consent form. * corrected visual acuity (cva) of 20/40 or better. * have a valid driver's license. * depth perception of at least 100 arc seconds. * other protocol-specified inclusion criteria may apply. exclusion criteria: * ocular pathology, degeneration, or media opacity. * color vision defect. * use of ocular or systemic medications that impact macular pigment density or reaction time, including but not limited to, lutein, zeaxanthin, barbiturates, tranquilizers or amphetamines. * system conditions affecting connective tissue or sensory-motor coordination. * other protocol-specified exclusion criteria may apply.

Keywords: cataract intraocular lens (iol) acrysof
evaluation of intra-operative ultrasound contrast enhancement in the evaluation of liver tumors

Conditions: Liver Tumors

Summary: the primary purpose of this study is to demonstrate the safety and effectiveness of using an intra-operative ultrasound contrast agent(definity®) for the identification of known liver tumors.

the primary objective of this study is to demonstrate the safety of the use of intra-operative ultrasound contrast (definity®) administration. the secondary objective of this study is to demonstrate the improved image quality and conspicuity of known liver tumors using contrast enhancement.

Eligibility criteria:
inclusion criteria: 1. undergoing a hepatic resection or hepatic ablation of pre-operative visualized liver tumor: 2. ≥ 18 years of age 3. if female of child-bearing potential, negative pregnancy test within 14 days prior to surgery 4. if subject is a sexually active male or a sexually active female of child-bearing potential, subject agrees to use a medically accepted form of contraception from the time of enrollment to completion of all follow-up study visits. 5. irb-approved informed consent, signed by the subject or the subject's legally authorized representative. ≥ 18 years of age exclusion criteria: 1. not a suitable candidate for operation

Keywords: definity liver tumors intra operative contrast liver cancer hepatic tumors identify liver tumors surgery liver tumors patients with known hepatic tumors
the role of artificial uterine contractions in perinatal respiratory morbidity of term infants delivered by elective caesarean section

Conditions: Neonatal Respiratory Distress

Summary: in this study, the investigators aim to investigate if artificial uterine contractions prior to elective caesarean section delivery may have an impact on the respiratory morbidity of term neonates.

accumulating evidence suggests that the respiratory morbidity of infants is lower if delivered by caesarean section after the spontaneous onset of uterine contractions, or after oxytocin exposure. moreover, benefits for the mother due to stretching of the lower uterine segment and possible lower blood loss are plausible. in obstetrics, there is a well described and standardized way to induce artificial uterine contractions in order to predict fetal wellbeing and tolerance of labor, without inducing the labor itself. this is the oxytocin challenge test (oct). although the oct has not been performed previously in the context of planned elective caesarean section deliveries, it is generally considered a safe procedure if appropriate monitoring is granted. hence evaluation of the role of artificial uterine contractions in perinatal respiratory morbidity of term infants delivered by elective caesarean section is possible and of interest.

Eligibility criteria:
inclusion criteria: * term/near-term pregnancy (36+0 - 41+6 weeks of gestation) * planned delivery by elective caesarean section * absence of any exclusion criteria * informed consent obtained exclusion criteria: * term premature rupture of membranes (tprom) * spontaneous onset of uterine contractions * known serious congenital malformations * placenta praevia/vasa praevia * abnormal placental attachment * intrauterine growth restriction (birth weight below 3rd centile for given gestational age and gender)
c7-t1 epidural steroid injections versus targeted injection for treatment of cervical radicular pain

Conditions: Radicular; Neuropathic, Cervical; Neck Pain

Summary: cervical radicular pain is a common, disabling problem, occurs in 83:100,000 individuals per year. symptoms are most often caused by intervertebral disc herniation (21.9%) or central or foraminal stenosis from spondylosis (68.4%). patients complain of pain in the head, neck, scapula or arm. the diagnosis of radicular pain is made clinically by history and physical examination, supported by imaging studies and electrodiagnostic tests. no study has compared the differences in pain, medication utilization, functional outcomes, or patient satisfaction between interlaminar and targeted epidural injections in the cervical spine. in theory, the technique of targeted epidural steroid delivery with a catheter has a lower risk of accidental vascular trespass or disc penetration during the procedure, and far less risk of dural penetration or spinal cord injury at rostral levels of the cervical spinal cord as compared with the interlaminar technique. the investigators hypothesize that this technique results in superior pain control, decreased medication use, improved function and fewer repeat injections. this data could improve patient safety and affect the evolving treatment guidelines for cervical epidural injections.

cervical radicular pain is a common, painful, disabling problem, often treated by epidural steroid injection (esi). two techniques of steroid delivery into the cervical epidural space include the transforaminal and interlaminar approaches. we aimed to determine if the ciesi with versus without a catheter is associated with superior clinical outcomes at follow-up. we hypothesized that the use of a targeted epidural catheter technique would result in superior pain control, function, decreased analgesic use, and lower surgical incidence as compared to standard ciesi at c7-t1.

Eligibility criteria:
inclusion criteria: * all patients ages 18-75 with c2-6 unilateral radicular pain who are scheduled to undergo cervical epidural steroid injection treatment. * pain lasting greater than 2 weeks. * pain resistant to a trial of conservative therapy (i.e. oral steroids,nonsteroidal anti-inflammatory drugs, opioids, muscle relaxants, physical therapy or chiropractic care) exclusion criteria: * patient refusal. * lack of consent. * systemic infection or local infection over planned injection site in posterior cervical spine. * bleeding disorder, current use of anticoagulants or anti-platelet medications. * intrinsic spinal cord lesions in the cervical region. * history of central neurologic, cerebrovascular, demyelinating or muscular disease. * concomitant use of oral or injected steroids. * allergy to medications being used for injection procedures. * inability to communicate with staff or to participate in follow up. * pregnancy. * inability to perform handgrip or arm strength testing. * cognitive deficit or motor neuron disease. * daily opiate use that preceded the onset of cervical radicular symptoms or daily opiate use exceeding 3 months prior to study inclusion