whole body vibration for the improvement of health and functioning in participants with chemotherapy-induced peripheral neuropathy

Conditions: Chemotherapy-Induced Peripheral Neuropathy; Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Summary: this clinical trial studies how well whole body vibration works in improving the health and functioning of participants with chemotherapy-induced peripheral neuropathy. peripheral neuropathy is a condition caused by exposure to chemotherapy drugs that may involve numbness/tingling and/or pain in the hands and feet, which can have adverse effects on daily life. whole body vibration may cause weight loss and improve mobility and pain levels in cancer survivors who report symptoms of peripheral neuropathy.

primary objectives: i. determine the feasibility and safety of whole body vibration (wbv) in adult cancer survivors with chemotherapy-induced peripheral neuropathy (cipn). ii. determine the effect of wbv training on physical functioning in adult cancer survivors with cipn. iii. explore the effect of wbv training on symptom relief (neuropathy symptoms, pain, fatigue) and readiness to exercise in adult cancer survivors with cipn. outline: participants are randomized to 1 of 2 groups. group i (wbv): participants complete two 10-minute wbv sessions per day, 7 days per week for 12 weeks. group ii (usual care \[uc\]): participants receive usual care and keep their same physical activity or dietary habits over 12 weeks. after completion of study treatment, participants are followed up at 12 weeks.

Eligibility criteria:
inclusion criteria: * histologically confirmed cancer stage i-iiic (confirmed by self-report on the health history questionnaire. if the patient is unable to confirm, we will send a letter to their physician to confirm for this criterion) * previous chemotherapy within five years of enrollment (confirmed by self-report on the health history questionnaire. if the patient is unable to confirm, we will send a letter to their physician to confirm for this criterion) * presence of mild-very severe cipn symptoms (confirmed by assessment using the patient-reported outcomes \[pro\]-common terminology criteria for adverse events \[ctcae\] criteria) * age 18 years or older at enrollment (confirmed by self-report on the health history questionnaire) exclusion criteria: * body weight \> 275 pounds (confirmed by self-report on the health history questionnaire) * a medical condition, movement or neurological disorder, or medication use that contraindicates participation in low intensity exercise and/or wbv (confirmed by self-report on the health history questionnaire, and by physician clearance, if in the professional opinion of the principal investigator, dr. kerri winters-stone, contraindications other than those identified by the patient or physician are present, she may consider the participant ineligible.) * presence of any known metastases (confirmed by self-report on the health history questionnaire. if the patient is unable to confirm, we will send a letter to their physician to confirm for this criterion) * adjuvant treatment for cancer within previous six weeks, other than hormone blocking, targeted or immunotherapy (confirmed by self-report on the health history questionnaire. if the patient is unable to confirm, we will send a letter to their physician to confirm for this criterion)