Kornimate/medical-research-clean huggingface dataset:
resistance exercise effect on physical performance and functional status in sarcopenic older women

Conditions: Sarcopenia

Summary: aging is characterized by a progressive loss of multiple physical and cognitive abilities. from these changes, the most important one is the loss of muscle mass, which has been called "sarcopenia". resistance exercise is a therapeutic approach for sarcopenia, nevertheless there is no universal consensus. therefore, this research is interested in determining the effect of a resistance exercise program on physical performance and/or functional status in sarcopenic older women. the main study hypothesis is that a program of resistance exercise will improve physical performance and functional status in sarcopenic older women compared against general recommendations. this is a single-blind, controlled clinical trial, including women\> 70 years, living in the community with sarcopenia. those who agree to participate, will be randomly assigned to one of the following groups: 1. resistance exercise group 2. general recommendations group (control) the study will last 24 weeks, with 4 measurements performed at baseline, week 6, 12 and 24. multilevel models (random effects) will be constructed for the comparison between the two groups. tests will be conducted with a p=0.05 and confidence intervals at 95%. this protocol has been approved by the local ethics committee.

study withdrawn.

Eligibility criteria:
inclusion criteria: * body mass composition by bia with skeletal muscle mass \<6.76kg/m2 * speed gait of \<0.8m/sec * handgrip strength (adjusted for bmi) less than 20kg exclusion criteria: * current diagnosis of malnutrition (bmi \<19kg/m2) * decompensated heart failure (nyha iii or iv) * hemiplegia or hemiparesis due to cerebral vascular disease * exacerbation of chronic obstructive pulmonary disease * dementia (any type, moderate or severe stage) * uncontrolled diabetes mellitus (glycosylated hemoglobin \>8%) * severe pain in hips, knees or ankles * fracture of lower limb in the last 6 months * myocardial infarction within the past 6 months * severe hypertension (sbp \> 180mmhg or dbp \> 110 mmhg) * orthostatic hypotension

Keywords: sarcopenia elderly women resistance exercise
acupressure and training for coping with pms

Conditions: Premenstrual Syndrome; Acupressure

Summary: the study was conducted to determine the effect of acupressure and training, given to women under the guidance of health belief model for coping with premenstrual syndrome, on the premenstrual symptoms and quality of life. this study was conducted to as a randomized controlled trial. the population of the study was composed of all women with pms registered in fhcs no. 4 and 14 located in the city center. the sample of the study consisted of women including 51 women in training +acupressure group, 55 women in training group and 57 women in control group. the data were collected with participant information form, pmss and whoqol-bref in the study. training and acupressure were administered to the acupressure + training group. only the training for coping with premenstrual syndrome was given to the training group. the data collection forms were reapplied to all groups 12 weeks after the pretest.

premenstrual syndrome is an important collection of symptoms affecting approximately one-fifth of women in reproductive age. acupressure is an intervention found in the nursing intervention system and defined as applying constant and powerful pressure on certain/specific points of the body in order to reduce pain, provide relaxation and relief, and to prevent or reduce nausea. many studies conducted in gynecology have shown that acupressure decreased menstrual distress, premenstrual symptoms, back pain in women experiencing dysmenorrhea, labor pain and nausea and vomiting during pregnancy. in addition, it was shown in the studies that training given for pms decreased the premenstrual symptoms

Eligibility criteria:
inclusion criteria: having regular menstruation (between 21-35 days), not having any psychiatric diagnosis or any gynecological diseases not using contraceptives, not having tissue deformity in the extremities. exclusion criteria: having any psychiatric diagnosis having any gynecological diseases
adherence to treatment with pegintron pen plus rebetol in treatment-naïve adult patients with hepatitis c in romania (study p04247)

Conditions: Hepatitis C, Chronic; Hepatitis C

Summary: adherence to the prescribed treatment regimen with pegintron and rebetol affects the chance of achieving a sustained virologic response in patients with hepatitis c. the objective of this study is to evaluate the proportion of patients who complete treatment with pegintron pen and rebetol while participating in a patient assistance program. the patient assistance program can consist of prophylactic treatment (eg, with growth factors, psychiatric medications) or other interventions (eg, psychotherapy, patient support groups, visiting nurse, nurse telephone calls, educational literature).


Eligibility criteria:
inclusion criteria: * treatment-naïve patients with hepatitis c * patients treated with pegintron pen and rebetol * patients receiving patient assistance program exclusion criteria: * not applicable
donor atorvastatin treatment for preventing severe acute graft-versus-host disease in patients undergoing myeloablative peripheral blood stem cell transplantation

Conditions: Malignant Neoplasm

Summary: this phase ii trial studies donor atorvastatin treatment for the prevention of severe acute graft-versus-host disease (gvhd) in patients undergoing myeloablative peripheral blood stem cell (pbsc) transplantation. giving chemotherapy and total-body irradiation (tbi) before a donor pbsc transplant helps stop the growth of cancer cells. it may also prevent the patient's immune system reject the donor's stem cells. when the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. giving atorvastatin to the donor before transplant may prevent this from happening.

primary objectives: i. to assess whether 2 weeks of donor statin treatment reduces the risk of severe acute gvhd. secondary objectives: i. to assess whether 2 weeks of statin treatment of normal pbsc donors is feasible, tolerable and safe. outline: donors receive atorvastatin orally (po) beginning on day -14 and continuing until the last day of stem cell collection.

Eligibility criteria:
inclusion criteria: * human leukocyte antigen (hla)-identical sibling donor * myeloablative preparative regimen (i.e., \>= tbi 12.0 gy, \>= busulfan (bu) 8.0 mg/kg po, \>= bu 6.4 mg/kg intravenously (iv), \>= treosulfan 42 g/m\^2 iv) according to investigational study or standard treatment plan; other "myeloablative" preparative regimens are acceptable as long as they are approved by the principal investigator or designee * transplantation of pbsc * cyclosporine (csp)-based postgrafting immunosuppression * willingness to give informed consent * donor: age \>= 18 years * donor: hla genotypically identical sibling * donor: willingness to give informed consent exclusion criteria: * nonmyeloablative preparative regimen * participation in an investigational study that has acute gvhd as the primary endpoint * the allogeneic pbsc donor has a contraindication to statin treatment * donor: age \< 18 years * donor: active liver disease (alanine aminotransferase \[alt\] or aspartate aminotransferase \[ast\] levels \> 2 times the upper limit of normal \[uln\]) * donor: history of myopathy * donor: hypersensitivity to atorvastatin * donor: pregnancy * donor: nursing mother * donor: current serious systemic illness * donor: concurrent treatment with strong inhibitors of hepatic cytochrome p450 (cyp) 3a4 (i.e. clarithromycin, erythromycin, protease inhibitors, azole antifungals) * donor: current use of statin drug * donor: failure to meet fred hutchinson cancer research center (fhcrc) or local criteria for stem cell donation * donor: total creatinine kinase \> 2 times the uln
healthy living in pregnancy

Conditions: Lifestyle; Weight Gain; Pregnancy

Summary: multicenter and multidisciplinary public health project in 10 regions of bavaria, a federal state of germany, targeting maternal and fetal health. the objective of this trial is to evaluate the efficacy of a lifestyle intervention program focusing on diet, physical activity and weight monitoring during pregnancy. the intervention comprises 4 individual counseling sessions addressing healthy living. primary outcome: gestational weight gain. secondary outcomes are pregnancy and obstetric complications like gestational diabetes and rate of caesarean sections as well as offspring health. the lifestyle intervention program is adapted to the german health care system to allow an immediate implementation after successful evaluation.


Eligibility criteria:
inclusion criteria: * gestational age ≤ 12th week of gestation * age: 18 years to 43 years * prepregnancy bmi ≥ 18.5 kg/m2 and ≤ 40.0 kg/m2 * sufficient german language skills * written informed consent exclusion criteria: * multiple pregnancy * any condition preventing physical activity such as placenta praevia, persistent bleeding, cervical incompetence * prepregnancy diabetes or early diagnosed gestational diabetes * uncontrolled chronic diseases (e.g. thyroid dysfunction) * psychiatric or psychosomatic diseases * any condition that may interfere with the study protocol
vitamin d to reduce colds and asthma attacks in young children

Conditions: Asthma

Summary: viral infections are the main cause of asthma attacks in preschoolers, an age group with the highest rate of emergency visits due to asthma. while high doses of inhaled or oral corticosteroids provide benefits, these have been associated with adverse outcomes. most asthmatic children have lower blood levels of vitamin d compared to non-asthmatic children. low vitamin d level has been linked to more frequent and more severe asthma attacks as well as with higher dose requirement of inhaled corticosteroid. recent studies show that vitamin d supplements can reduce the number of asthma attacks triggered by viral infections in children. unfortunately, most people forget to take vitamin d every day during the fall and winter season as recommended in canada. a solution is to give a vitamin d bolus by mouth. this has been shown to safely and effectively increase vitamin d levels in children. the investigators hypothesise that a vitamin d bolus given in clinic will sufficiently increase the blood level of vitamin d to prevent the expected winter decline in vitamin d, compared with placebo in preschool-aged children with asthma. this six-month pilot randomized controlled trial aims to: (1) show that a vitamin d bolus is superior to placebo in raising vitamin d levels; (2) record the number of asthma attacks and viral infections in enrolled participants; and (3) identify problems that may call for protocol changes.


Eligibility criteria:
inclusion criteria: * children aged 1-5 years * physician-diagnosed asthma as per gina guidelines * upper respiratory tract infections as the main asthma exacerbation trigger * ≥4 respiratory infections in the past 12 months * ≥1 exacerbation requiring rescue oral steroids in the past 6 months or ≥2 in the previous 12 months. exclusion criteria: * extreme prematurity (\<28 weeks gestation) * infants \<12 months of age * breastfed infants with no vitamin d supplementation * recent (\<1 year) immigrants from countries where rickets and malnutrition prevalent * other chronic respiratory disease (broncho-pulmonary dysplasia; cystic fibrosis) * endocrine disorder of calcium/ vitamin d metabolism * disorder/ disease with associated malabsorption (inflammatory bowel disease) * kidney/ liver disease * sickle cell anemia * medications known to interfere with bone metabolism/ vitamin d levels * vitamin d supplementation \>1000 iu/ day in past 3 months * unable to attend medical visit in 3-4 months * plan to leave the province during the next 6 months.

Keywords: asthma virus diseases pediatric rct steroid
the impact of a self-help coping app on distress levels in men experiencing infertility

Conditions: Stress Reduction

Summary: the purpose of this study is to determine if the use of a new app, fertistrong, is associated with decreased levels of anxiety and depression in men who have infertility or whose partner has infertility.

individuals who are experiencing infertility report high levels of anxiety and depression. a recent study (1) documented that both men and women involved in the treatment of infertility expressed emotional distress. research on the female partner of an infertile couple documents that psychological interventions, especially those with a cognitive-behavior therapy (cbt) focus, are associated with significant decreases in levels of anxiety and depression (2). subsequent research has also shown that both members of the infertile couple definitively underutilize the psychological services offered to them. thus, new ways to provide psychological relief to these individuals is needed. this has lead to the development of a new app, fertistrong. this app is targeted at men- either men with infertility or men whose partner has infertility. study requirements: 1. study participants will be asked to complete an on-line questionnaire. 2. once completed, the study participant will be randomly assigned to one of two groups. one group will be provided the mobile app to use for 30 days. the second group will be provided the app after 30 days. 3. after the 30 day period, each group will be asked to complete a follow-up questionnaire. each questionnaire will take approximately 15-20 minutes to compete. men who are directly seeking care or whose partners is seeking care at any fertility center of illinois location are invited to participate.

Eligibility criteria:
inclusion criteria: * all men who are receiving care, or whose partner is receiving care, at fertility centers of illinois during the study period. exclusion criteria: 1. does not have daily access to a smart phone 2. does not read or understand english

Keywords: infertility distress coping men
preterm infants may better tolerate warmer feeds

Conditions: Prematurity; Feeding Disorder Neonatal

Summary: feeding intolerance is frequent among preterm infants in neonatal intensive care units (nicus). although there are many studies about enteral nutrition strategies and content in preterm infants, no evidence-based standards exist for the optimal milk temperature for preterm infants. therefore, in this study the investigators aimed to examine the effects of feeding temperature and the possible morbidities.

feeding intolerance is one of the most frequent problems among preterm infants. these infants are fed with expressed breast milk or preterm formulas of which the temperature is not routinely measured. in this study, the investigators aimed to examine the effects of feeds with warm versus room temperature milk in preterm infants. infants with a birth weight of ≤1500 g or gestational age of ≤ 34 weeks were included in the study and assigned to two different feeding temperature groups (22-24°c and 32-34°c). some infants in both groups were exclusive breast milk fed and some received artificial milk. feeding tolerance of patients in both groups and the consequences were evaluated.

Eligibility criteria:
inclusion criteria: * infants born to birth weight of ≤1500 g * infants born to gestational age of ≤ 34 weeks exclusion criteria: * genetic syndrome * gastrointestinal system anomalies * patients born small for their gestational age

Keywords: prematurity enteral nutrition feeding tolerance temperature
lactate levels during cardiopulmonary bypass in pediatric patients

Conditions: Heart Defects, Congenital

Summary: many variables measured in critically ill patients have been used to estimate severity of disease, prognosticate morbidity and mortality, evaluate costs of treatment, and finally indicate specific treatment and monitor the adequacy of treatment and its timing. it is unlikely that one measurement can replace all of these, but in the remainder of this manuscript the investigators will show that lactate levels may come close. although in our mind strongly linked to tissue hypoxia, lactate levels follow many more metabolic processes not related to tissue hypoxia and, therefore, subject to many disturbances found in various clinical situations

forty consecutive pediatric patients who required cardiopulmonary bypass for repair or palliation of complex congenital heart disease will be enrolled in this study. patients for the study were selected by convenience sampling, without randomization or control of surgical procedure, conduct of anesthesia, or cpb management. patients will be monitored intra-operatively using ecg, invasive and non-invasive blood pressure monitoring, pulse oximetry and capnography for determination of end tidal co2 ( etco2 ) and nasopharyngeal temperature. after induction of anesthesia and placement of an intra-arterial catheter 1 ml of arterial blood will collected into a heparinized 3 ml blood gas syringe and immediately analyzed on the arterial blood gas analyzer (gem premier 3000) for blood gas, hematocrit, electrolytes, calcium and glucose. management strategy of cardio-pulmonary bypass (cpb) was standardized for all the patients. lactate samples will drawn at specific time points within 5 time intervals: before cpb after induction, during cooling on cpb, during rewarming on cpb, immediately after cpb in the operating room, and after admission to the post-operative intensive care unit. differences in lactate levels related to diagnosis will examined. to examine the effect of patient diagnosis and surgical risk on serum lactate level and outcome, the investigators separated patients into surgical risk categories risk adjustment for congenital heart surgery (rachs-1). this classification does not include heart transplantation. patient mortality and the prevalence of postoperative complications for each of the 3 surgical risk categories relative to the change in lactate will examined.

Eligibility criteria:
inclusion criteria: * age range (1-12 years) * usage of cardiopulmonary bypass exclusion criteria: * chest problems * renal problems * hepatic problems

Keywords: lactate congenital cardiac defect cpb pediatric
immediate trial - out of hospital administration of glucose, insulin and potassium.

Conditions: Angina, Unstable; Cardiovascular Diseases; Heart Diseases; Coronary Disease; Myocardial Infarction; Heart Failure, Congestive

Summary: the purpose of this study is to test the impact of pharmacological myocardial metabolic support, in the form of intravenous (iv) glucose, insulin and potassium (gik), for the treatment of patients with threatened or established acute myocardial infarction (ami).

background: basic and clinical research suggests intravenous gik metabolic myocardial support reduces ischemia-induced arrhythmias, progression from unstable angina pectoris (uap) to acute myocardial infarction (ami), myocardial infarction (mi) size, and mortality. also, for st elevation mi (stemi), gik may prolong time of benefit of coronary reperfusion. these effects should reduce short- and long-term mortality from acs, including ami and uap, and the propensity for heart failure (hf). these benefits are related to the earliness of acs, when both risk and opportunity to save lives are highest. design narrative: this is a randomized, placebo-controlled, double-blinded, multicenter clinical trial of immediate gik as early as possible in acs in the prehospital emergency medical service (ems) setting. distinct from prior and ongoing gik trials, this will test gik for all acs rather than only for ami or stemi in prehospital ems. the primary hypothesis is that early gik will prevent or reduce the size of acute myocardial infarction. major secondary hypotheses posit gik will reduce mortality (30 days and 1 year), reduce pre- or in-hospital cardiac arrest and the propensity for heart failure. other hypotheses address mechanisms of these effects.

Eligibility criteria:
inclusion criteria: * symptoms of threatened or established ami including but not limited to: 1. chest pain, discomfort, or tightness 2. arm or shoulder pain 3. jaw pain 4. epigastric discomfort 5. shortness of breath * 12-lead electrocardiogram (ecg) with two or more contiguous leads with st elevation greater than 1 mm, st depression greater than 0.5 mm, t wave inversion or other t wave abnormalities (hyperacute t waves), or left bundle branch block (not known to be old). identification aided by the acute cardiac ischemia time-insensitive predictive instrument (aci-tipi)and thrombolytic predictive instrument (tpi) decision support software (aci-tipi \>= 75% and tpi detection of suspected stemi). exclusion criteria: * end-stage kidney failure requiring dialysis * rales present more than halfway up the back * unable to comply with the requirements of the study * incarcerated * known to be pregnant

Keywords: acute coronary syndrome
normobaric oxygen (nbo) therapy in acute migraine

Conditions: Migraine

Summary: this is a pilot study investigating the therapeutic potential of breathing 100% oxygen in acute migraine headache.

a total of 40 adult subjects will be enrolled, male and female. subjects will be consented to inhale either normobaric oxygen (nbo) or room air for 30 minutes at the start of their migraine attacks. outcomes will be assessed during and after gas treatment.

Eligibility criteria:
inclusion criteria: * adult subjects with frequent migraine (at least 1 attack per month) exclusion criteria: * secondary (non-migraine) headache * chronic obstructive pulmonary disease * pregnant

Keywords: migraine oxygen therapy
effectiveness of creatine in preventing muscle aching from cholesterol-lowering statin drugs

Conditions: Hypercholesterolemia; Aches; Cramps; Weakness

Summary: the purpose of this study is to determine of creatine will prevent or treat the muscle toxicity side effect of statin drug therapy, whose symptoms are aching, cramping, and weakness. this is tested in patients who have had this side effect from 3 different statin drugs.

muscle toxicity is the most common limiting side effect of statin therapy. biochemical studies have suggested the presence of intramuscular creatine deficiency in patients with muscle toxicity. this is a test of oral creatine supplementation in statin intolerant subjects as a method of preventing the onset of this side effect as well as resolving these symptoms when present during statin therapy.

Eligibility criteria:
inclusion criteria: * hypercholesterolemia in need of aggressive treatment, defined as a high risk of a vascular event, thus subjects with diabetes, pre-diabetes, or known vascular disease * intolerance (i.e. muscle toxicity symptoms) of at least 3 statin drugs, each confirmed on rechallenge exclusion criteria: * history of elevated cpk or rhabdomyolysis while taking a statin, * cpk levels elevated above the normal range at baseline, * pregnancy. * renal insufficiency, defined as a serum creatinine ≥ 2.0 mg/dl. * history of congestive heart failure.

Keywords: hydroxymethylglutaryl-coa reductase inhibitors creatine adverse effects muscle toxicity