Kornimate/medical-research-clean huggingface dataset:
epigenetic regulation of bdnf in schizophrenia

Conditions: BDNF, DNA Methylation, Suicide, Drug Responses.

Summary: in this proposal, we will (1) detect the associations between bdnf and trk b gene dna methylation, histone modification, psychotic symptoms, obesity, suicide and antipsychotic drug responses in taiwanese patients (2) discuss the possible mechanisms of epigenetic regulation of bdnf and trk b in schizophrenia patients.

a total 160 subjects (80 subjects every year, including 40 healthy controls and 40 schizophrenia patients) will be recruited during a 2-year period. the first year, the baseline data of bdnf and trk b dna methylation, protein and mrna levels in all subjects will be collected and the following 1 months data will also be collected in schizophrenia with antipsychotic drug treatments. the second year, the baseline data of bdnf and trk b histone modification in all subjects will be collected.

Eligibility criteria:
inclusion criteria: - 1. the clinical screening and assessment in schizophrenic patients： 1. 40 schizophrenia patients will be recruited in psychiatric inpatients according to dsm-iv criteria (apa, 1994) by a structured interview (scid). the assessment will be done by two senior psychiatrists. the intra-rater and inter-rater reliability will be done before this project started 2. age : 18-65 years old. 3. the patients had the ability to complete the written inform consent.。 4. the choice of antipsychotic drugs depended on the need of patients in natural treatment procedure. they included conventional drugs, eg.haloperidol 10-20 mg/day；sda (serotonin dopamine antagonist) drug, eg. clozapine 100-400 mg/day or risperidone 3-6mg/day. the choice of the medication was according to the need of patients including previous responses and side effects. 5. panss (positive and negative syndrome)(kay, 1987,1988\&1989) for positive, negative symptoms and severity. 6. check body mass index (bmi): if bmi\ 27: obesity (taiwan criteria, 2004). if the patients were overweight or obesity, the lipid profiles would be done and we would consult the experts to assess these patients. the condition for diet control and daily activity will be observed. if the condition was extremely abnormal, the case will be excluded. 7. suicide behavior in tis study includes complete suicide and suicide attempt. exclusion criteria: 1. the patients had systemic diseases, including metabolic, heart, and liver diseases。 2. the patients had received any drugs before entering this protocol. 3. the patients were heavy smokers or dependent on alcohol.

Keywords: schizophrenia, bdnf, dna methylation, histone modification
effects of dexmedetomidine on quality of recovery and analgesia after video-assisted thoracoscopic surgery

Conditions: Lung Cancer; Video-assisted Thoracoscopic Surgery

Summary: dexmedetomidine is a selective α2 adrenergic agonist that can be considered analgesics, anxiolytic,and anti-stress effect . this randomized, double-blind placebo-controlled trial of intraoperative dexmedetomidine for improvement of quality of recovery and analgesia from surgery. patients scheduled to undergo video-assisted thoracoscopic surgery (vats) will be enrolled. patients will be recruited before the date of their surgery and will complete the quality of recovery-40 (qor-40) questionnaire before their surgery and at 24 and 48 hours post op. they will also complete clinically significant pains score and oxygenation from the postanesthetic recovery unit (pacu).


Eligibility criteria:
inclusion criteria: 1. the inclusion criteria included patients scheduled video-assisted thoracoscopic surgery for lung cancer 2. adults above 20 years of age and providing informed consent. 3. american society of anesthesiologists (asa) physical class ii, \& iii patients exclusion criteria: 1. severe functional liver or kidney disease 2. history of chronic pain requiring opioid treatment 3. arrhythmia or received treatment with antiarrythmic drug . 4. severe bradycardia (hr \< 45 bpm) and av block 5. pathologic esophageal lesion (esophageal stricture or varix ) 6. pregnancy 7. psychiatric/central nervous system disturbance that would preclude completion of the qor-40 questionnaire 8. history of alcohol or drug abuse

Keywords: dexmedetomidine quality of recovery
melatonin in youth: n-of-1 trials in a stimulant-treated attention deficit hyperactivity disorder (adhd) population

Conditions: Attention Deficit/Hyperactivity Disorder; Initial Insomnia

Summary: this study is a multi-center, randomized, triple-blind, placebo-controlled parallel-group trial, in which each participant is offered an n-of-1 trial. the purpose of this study is to assess the efficacy and safety of melatonin (3 mg or 6 mg) compared with placebo for initial insomnia in children with attention-deficit disorder.


Eligibility criteria:
inclusion criteria: * school-aged children and adolescents between the ages of 6 to 17 years * confirmed diagnosis of adhd as defined by the diagnostic and statistical manual of mental disorders, fourth edition (dsm-iv) exclusion criteria: * co-morbid psychiatric/neurological diagnoses that may affect sleep * co-morbid seizure disorder * co-morbid sleep disorder * concurrent use of immunosuppressive drugs, blood pressure drugs, selective serotonin re-uptake inhibitors or anticoagulant drugs; * pregnancy or breastfeeding

Keywords: melatonin
use of the spanner temporary prostatic stent as an alternative to a urinary catheter to achieve bladder drainage in men

Conditions: Urinary Retention

Summary: the spanner is being evaluated for use to manage voiding dysfunction and lower urinary tract symptoms in subjects to achieve bladder drainage in men unfit for other treatments.


Eligibility criteria:
inclusion criteria: * age \> 45 years; * in urinary retention and catheterized (indwelling or intermittent) for less than 180 days; * documented diagnostic history (within 180 days of study) of detrusor contractility (\>= 15 cmh2o) confirmed via pressure-flow test; * negative urinalysis on visit 1; * not a candidate for pharmacologic, minimally invasive or surgical treatment of the prostate; * charlson weighted index of comorbidity score \>= 1; * willing and able to sign the informed consent form; * willing and able to complete the follow-up protocol requirements; * experiencing catheter-induced discomfort. exclusion criteria: * current use of a urinary catheter daily for greater than 180 consecutive days immediately preceding entering into the study; * positive urinalysis on visit 1; * current or recent (within the last 6 months) urinary tract disease including urethral stricture, bladder stones, and other significant urological conditions or surgery; * surgery altering the normal uro-genital anatomy or abnormal urethral anatomy that affect the function of the lower urinary tract; * history of conditions associated with neurogenic bladder, including spinal cord injury, multiple sclerosis, or parkinson's disease; * use of anticholinergic medication; * gross hematuria when catheter is removed on visit 1; * known or suspected prostate cancer; * prior pelvic irradiation therapy; * prostatic urethral length \ 9 cm (combined length from the top proximal side of the bladder neck to the bottom distal side of the external sphincter); * intravesical enlargement of the median lobe of the prostate.
the effect of mindfulness-based tai chi chuan on mobile phone addiction among male college students is associated with executive functions

Conditions: Mobile Phone Addiction Behavior

Summary: the goal of this clinical trial is to investigate whether an 8-week mindfulness-based tai chi intervention can improve cognitive and executive functions, particularly inhibitory control, and reduce mobile phone addiction in male university students. it will also explore the potential mechanisms by which mindfulness-based tai chi affects mobile phone addiction behaviors. the main questions it aims to answer are: does mindfulness-based tai chi improve inhibitory control and reduce mobile phone addiction in male university students? does mindfulness-based tai chi enhance overall executive functions, including inhibition, updating, and shifting abilities? researchers will compare the experimental group (receiving mindfulness-based tai chi intervention) to the control group (maintaining their usual routine without intervention) to see if mindfulness-based tai chi leads to greater improvements in cognitive and executive functions and reduces mobile phone addiction. participants will: practice mindfulness-based tai chi for 8 weeks complete pre- and post-intervention assessments of mobile phone addiction, mindfulness levels, and executive function engage in weekly tai chi practice sessions complete self-report diaries of mobile phone usage and mindfulness experiences


Eligibility criteria:
inclusion criteria: * male university students not majoring in physical education. aged 18 years or older. a moderate level of dependence on mobile phones, with a score above 40 on the mobile phone addiction index (mpai). no regular exercise habits in daily academic life. willing to participate in an 8-week mindfulness-based tai chi training program and provide informed consent. no serious medical conditions. exclusion criteria: * the exclusion criteria include individuals with diseases that may affect training (such as cardiovascular diseases, respiratory diseases, and musculoskeletal disorders), as well as those diagnosed with mental disorders (such as depression, anxiety, obsessive-compulsive disorder, etc.).

Keywords: mobile phone addiction behavior executive function cognitive function
evaluation of a novel intrasaccular embolization device for the treatment of intracranial aneurysms

Conditions: Intracranial Aneurysms

Summary: the study is a prospective, multicenter single-arm cohort. the purpose of this study is to evaluate efficacy and safety of a novel intrasaccular embolization device for the treatment of intracranial aneurysms.


Eligibility criteria:
inclusion criteria: * patient must be 18-75 years of age at the time of screening. * patient must have a single ruptured or unruptured ia requiring treatment. * patient was able to comply with all aspects of the screening, evaluation, treatment, and the post-procedure follow-up schedule, signed and dated an written informed consent prior to initiation of any study procedures. exclusion criteria: * patient had an ia with characteristics unsuitable for endovascular treatment. * patient had vessel characteristics, tortuosity or morphology which precluded safe access and support during treatment with study device. * patient had vascular disease or other vascular anomaly that precluded the necessary access to the aneurysm for use of the study device. * patient had vasculitis, an intracranial tumor (except benign tumors that do not require treatment) or any other intracranial vascular malformations on presentation. * patient was taking anticoagulants or had a known blood dyscrasia, coagulopathy, or hemoglobinopathy. * patient was pregnant.
serratus intercostal block versus epidural analgesia in eventration: prospective observational study

Conditions: Eventration; Regional Anesthesia; Epidural; Anesthesia; Abdominal Hernia

Summary: adequate pain control, rehabilitation and early postoperative recovery are currently the model to follow according to the recommended guidelines.in this project the main objective is to evaluate 2 different analgesic strategies both intraoperatively and postoperatively, one based on 1. epidural analgesia and the other 2. echoguided serratus intercostal block prior to surgical intervention in eventration or abdominal wall repair interventions. we conducted an observational study with a low level of intervention. epidural analgesia prior to general anesthesia and serratus-intercostal block prior to general anesthesia) following the criteria applied in each case according to the operating room anesthesiologist until reaching the sample size and fulfilling the criteria of: abdominal eventration repair, over 18 years of age, asa i-iii. signature of the ic.

adequate pain control, rehabilitation and early postoperative recovery are currently model to follow according to the recommended guidelines.in this project the main objective is to evaluate 2 different analgesic strategies both intraoperatively and postoperatively, one based on 1. epidural analgesia and the other 2. echoguided serratus intercostal block prior to surgical intervention in eventration or abdominal wall repair interventions. the investigators conducted an observational study with a low level of intervention. epidural analgesia prior to general anesthesia and serratus-intercostal block prior to general anesthesia) following the criteria applied in each case according to the operating room anesthesiologist until reaching the sample size and fulfilling the criteria of: abdominal eventration repair, over 18 years of age, asa i-iii. signature of the ic. we will assess the analgesia provided by both techniques and to compare the results.

Eligibility criteria:
inclusion criteria: * abdominal eventration repair, * over 18 years old, * asa i-iii. * signature of the ic. exclusion criteria: * allergy to local anesthetic

Keywords: intercostal nerves, epidural,abdominal hernia
motion capture and analysis of nyit athletes

Conditions: Athletic Injuries

Summary: the purpose of this research is to: 1. determine the normal or existing dynamic biomechanics of college athletes and 2. test the effectiveness of osteopathic manipulative medicine in the treatment of athletic injuries. motion capture using vicon systems allows researchers to quantify characteristics of a body such as the range of motion of the hip or shoulder during an athletic technique such as kicking or shooting a basketball into the basket. the quantified information has been used before to better understand human mobility and performance. osteopathic manipulative medicine (omm) is manual medicine applied to joints, muscles, and connective tissue with a goal of improved body functions. research demonstrating effectiveness of omm on the musculoskeletal and associated connective tissue systems health includes, among others, prospective clinical trials of omm for treatment of neck pain, low back pain, and acute first- and second-degree ankle sprains.

volunteers for the study will be recruited through their athletic director, coach, or physician by an announcement made verbally or via email. the motion capture will be performed under matthew cornelius, ms using the vicon bonita motion capture system in the fine arts department of nyit. following the motion capture, body biomechanics will be analyzed to determine the range of motion of each joint in sagittal, frontal, and horizontal planes as well as the timing and sequence of the movements. the motion analysis will be compared to the sports physical exam, including the general, structural/neuromusculoskeletal, and central neurological (impact) exams. the comparison will add validity to the physical exam. in addition, determining if the quantitative, 3-dimensional motion analysis can be correlated with information from the physical exam with regards to restrictions to motion may be useful for athletes to optimize their abilities in the future. if during the course of the athlete's training and competition season s/he sustains an injury, s/he will be evaluated by the nyit athletics physician, who will randomly assign the injured athletes to either the 'standard of care without omm' or 'standard of care with omm' cohorts when medically appropriate. omm will be performed by an nyitcom physician specializing in family medicine and omt or neuromusculoskeletal systems and omm. "return to play' time and post-intervention/post-control quantitative motion analysis of biomechanics during the athletes demonstration of the same athletic maneuvers as before the injury.

Eligibility criteria:
inclusion criteria: * athlete at new york institute of technology * approval by nyit athletics physical for participation in sports * no current injury exclusion criteria: * illness preventing participation in sports * any current injury * younger than 18 years of age * pregnancy * allergy to spandex, nylon, or polyester
the 2-stage approach for reducing posterior wall puncture during the internal jugular vein catheterization

Conditions: Hematoma

Summary: to evaluate the effect of a 2-stage approach to the internal jugular vein when performing a central venous catheterization compared to the traditional one stage approach on the incidence of hematoma formation and success rate.


Eligibility criteria:
inclusion criteria: * patients who require a central venous catheter for their thoracic surgery exclusion criteria: * refuse to enroll * infection at insertion site * carotid artery disease * anomaly of central vasculature * hypertrophied thyroid * history of recent neck surgery

Keywords: hematoma formation success rate
retention of whole-body training effects on ambulatory function in children with cerebral palsy

Conditions: CP; Gait Disorders, Neurologic; Locomotion Disorder, Neurologic

Summary: this study will evaluate the retention effects of a four-week whole-body vibration training intervention in children with cerebral palsy. the primary outcomes for this study are gait function, including timed up and go and the two-minute walk test. secondary outcomes of this study include lower extremity gait function, coordination, and gait variability. for this study, a total of 10 children with cerebral palsy (cp) will be recruited with 5 being randomly placed into an experimental group and 5 being randomly placed into a control group. each participant, regardless of group, will complete pre-, post-, and retention testing, with a four-week whole-body vibration training intervention between the pre- and post-testing. the four-week whole-body vibration training will include three visits per week, with the experimental group receiving a vibration stimulus while standing on a vibration platform. vibration sessions will consist of three-minutes of vibration, followed by three minutes rest, completing this cycle three separate times. the control group will follow a similar pattern, but rather than experiencing vibration, they will hear a sound of the vibration platform through a speaker. once the four-week training session is finished, participants will return after a three-month retention period to determine whether ambulation function was retained.


Eligibility criteria:
inclusion criteria: * diagnosis of cerebral palsy * ability to walk independently exclusion criteria: * musculoskeletal injuries or conditions (other than cerebral palsy) which alter their independent walking ability

Keywords: cerebral palsy locomotion pediatrics
phase 1/2 study of mrtx849 in patients with cancer having a kras g12c mutation krystal-1

Conditions: Advanced Cancer; Metastatic Cancer; Malignant Neoplastic Disease

Summary: this study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of mrtx849 (adagrasib) in patients with advanced solid tumors that have a kras g12c mutation.

this study will evaluate the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of mrtx849 (adagrasib) in patients with advanced solid tumors with a kras g12c mutation. mrtx849 (adagrasib) is an orally-available small molecule inhibitor of kras g12c.

Eligibility criteria:
inclusion criteria: * histologically confirmed diagnosis of a solid tumor malignancy with kras g12c mutation * unresectable or metastatic disease * standard treatment is not available or patient declines; first-line treatment for nsclc for certain cohorts * adequate organ function exclusion criteria: * history of intestinal disease or major gastric surgery or inability to swallow oral medications * other active cancer

Keywords: kras nsclc colorectal cancer colon cancer metastatic cancer pancreatic cancer adagrasib stk11 mutation kras g12c
a safety and effectiveness study of jnj-31001074 in adults with attention-deficit/hyperactivity disorder.

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the purpose of this study is to evaluate the safety and effectiveness of jnj-31001074 compared to placebo in adults with attention deficit hyperactivity disorder (adhd).

this study is being done to assess safety and tolerability and to explore the effectiveness of a new, experimental drug in the treatment of attention deficit hyperactivity disorder in adults. approximately 144 adult patients with adhd will be recruited for the study. patients who meet study criteria will need to stop taking any adhd medications they are currently using. they will be randomly assigned to one of 3 treatment arms; each patient has an equal chance of receiving 10 mg jnj-31001017, 30 mg jnj-31001074, or placebo. placebo has no active drug. this is a blinded study, i.e. the patient, the study doctor and the study sponsor will not know what treatment the patient receives until all patients complete the study. patients will be dispensed a bottle containing study drug for the upcoming week at 4 of the study visits. the study doctor and the sponsor will monitor the study for the occurrence of possible side effects. in addition to a screening visit, patients will return weekly for 6 additional study visits including an end of study visit and a follow-up visit. patients will take study drug for a total of 4 weeks. after completing the study, patients may resume other adhd medications. medical and adhd history, physical examination, blood pressure, heart rate, temperature, weight and ecgs will be checked periodically throughout the study. blood samples will be taken for standard safety laboratory tests as well as for the measurement of the drug blood level. questionnaires relating to adhd and cognitive testing will be administered throughout the study. each day for four weeks, patients will take orally, at least one hour before eating in the morning, 1 tablet containing either 10 mg jnj-31001074, 30 mg jnj-31001074 or placebo.

Eligibility criteria:
inclusion criteria: * diagnosis of attention deficit hyperactivity disorder with symptoms from age 7 * in good general health * willing to not take any other adhd medication or start any behaviorial modification programs during the study * willing to use approved birth control throughout the study and for 3 months afterwards exclusion criteria: * any psychiatric condition including acute mood disorder, bipolar disorder, acute obsessive-compulsive disorder (ocd), anti-social personality disorder or borderline personality disorder * autism, asperger's syndrome, mental retardation * presence of motor tics, history of tourette's syndrome or family history of tourette's syndrome * history of substance use/abuse disorder or eating disorder * history of myocardial infarction, stroke, glaucoma, seizures, hypertension, heart rhythm abnormalities or color blindness * use of prescription medication or herbal supplements

Keywords: attention deficit hyperactivity disorder adhd jnj-31001074