Kornimate/medical-research-clean huggingface dataset:
feasibility and usability of mobile applications for monitoring cutaneous leishmaniasis treatment in colombia

Conditions: Cutaneous Leishmaniasis, American

Summary: an effectiveness-implementation sequential explanatory hybrid design type 2 was performed in two rural communities of colombia. a quasi-experimental study with historical control (standard of care) was designed to estimate the effectiveness of community-based intervention using the guaral+st mobile application (app). three implementation outcomes were evaluated: acceptability and usability by qualitative methods, and fidelity by quantitative methods

an effectiveness-implementation sequential explanatory hybrid design type 2 using mixed methods was performed in 2020 and 2021 in two study sites: pueblo rico, risaralda, and rovira, tolima. a quasi-experimental study with historical control (standard of care) was designed to evaluate the effectiveness of the community-based intervention supported by mhealth, in terms of monitoring of treatment of patients with cutaneous leishmaniasis. the effectiveness indicators i. number of follow-up contacts, ii. adherence to treatment, iii. adverse drug reactions, and iv. the therapeutic response were compared between the intervention and control groups. after the effectiveness evaluation was completed, three outcomes were assessed to inform the implementation of the community-based use of the app: acceptability, usability, and fidelity.

Eligibility criteria:
inclusion criteria: patients followed by chl with the app (effectiveness evaluation): * diagnosis confirmed by microscopy of tissue smear or culture * any age and gender * medical prescription for antileishmanial treatment * approved and signed informed consent * availability of chl to monitor treatment of the patients in the community inclusion criteria patients who received the standard of care (effectiveness evaluation): * clinical records of patients with confirmed cl at most two years prior to the start of this study * any age and gender * received antileishmanial treatment based on national guidelines inclusion criteria for participants of implementation evaluation (community health leaders) * residents of the rural areas of study sites * voluntary participation in the monitoring of patients using the mobile app
evaluating the tolerability and effects of berberine on major metabolic biomarkers: a pilot study

Conditions: Metabolic Syndrome

Summary: berberine is a dietary supplement that comes from the roots, stems, and bark of various plants and has been used for centuries in traditional chinese medicine. it may help lower cholesterol, lower blood sugar, and reduce inflammation.very few studies have been done in the united states to show how berberine effects cholesterol and blood sugar. this study is looking to see how berberine changes cholesterol and blood sugar, and to see how well it is tolerated.berberine is not a prescription medication but it appears to have similar actions to common prescription medications to lower cholesterol like statins, and to lower blood sugar like metformin. we are studying berberine to see if it may be a good option for people that do not want to take prescription medications.


Eligibility criteria:
inclusion criteria: * age ≥18 years and older * current ldl-c of ≥80 mg/dl or higher * current fasting triglyceride level of ≥300 mg/dl * meets current criteria for metabolic syndrome (≥3 of the following): waist circumference ≥ 35" female or ≥40" for male: triglycerides ≥ 150 mg/dl: low hdl-c \<40 mg/dl male or \<50 mg/dl female: elevated blood pressure ≥ 130/85 mmhg (or on bp medication): elevated fasting blood glucose ≥100 mg/dl * a male or a non-pregnant female * mentally competent to understand study rationale and protocol * able to speak and read english exclusion criteria: * currently taking any lipid-altering agents including but not limited to statins, niacin (\>500 mg), bile-acid sequestrants, ezetimibe, fibrates, and omega-3 fish/krill oils (\>1000 mg epa/dha). * prior evidence of a vascular event (e.g. stroke, myocardial infarction, revascularization, peripheral vascular disease) * current use of any oral hypoglycemia agent or parenteral medication for diabetes mellitus (e.g. glp-1 agonists, insulin) * currently taking any drugs with the potential to interact with berberine, including but not limited to cyclosporine, simvastatin, lovastatin, metformin, saquinavir, darunavir, tacrolimus, sirolimus. * previous history of diabetes mellitus, hba1c ≥ 6.5%, or fpg \> 126 mg/dl * chronic disease involving, hepatic, renal, or coronary heart disease, systemic infection (e.g. hiv) or organ transplantation * currently taking systemic steroidal drugs * dependence on alcohol (\> 10 drinks per week) or illicit drugs * pregnant or lactating * participation in any other clinical trial within the last 30 days * presence of any medical or psychological condition that in the opinion of the investigator will compromise safe subject participation for the duration of the study * acute or chronic gi conditions (e.g. irritable bowel syndrome, ulcerative colitis)
home-exercise vs general physical activity: effect on health-related quality of life

Conditions: Health-Related Quality of Life

Summary: the purpose of this randomized controlled trial is to evaluate the effectiveness of an exercised-based programme developed for older people admitted at a geriatric outpatient clinic and to see if a home-exercise program enhances the effect. the outcomes considered is health-related quality of life, balance-self confidence, balance and mobility.

older people discharge from hospital often have decreased functional and physiological reserve that make them vulnerable of being dependent of others. research have shown that older people discharge from hospital are vulnerable for functional decline during hospital stay and this decline can persist 6 to 18 months after discharge from hospital.exercise interventions are proven to have effect on mobility, balance and falls among community-dwelling older people and several studies have shown that deconditioning as a consequence of disuse is reversible with training even in very old individuals. however, few studies have evaluated the effects of physical activity promotion and exercise intervention among elderly recently discharge from a geriatric outpatient clinic.

Eligibility criteria:
inclusion criteria: * home-dwelling patients who were admitted at the geriatric clinic. * assessed by a doctor to tolerate training * able to walk in the corridor for 3 min with or without assistive device exclusion criteria: * cognitive disorders mini mental status \< 24

Keywords: hlrq elderly balance mobility fear of falling
a universal electronic health record-based improve dd vte risk assessment model for the prevention of thromboembolism in hospitalized medically ill patients

Conditions: Venous Thromboembolism; Arterial Thromboembolism

Summary: this study will be a multicenter clustered randomized trial of patients in hospitals in which a universal "smart on fhir" platform-based ehr-embedded improve dd vte clinical prediction rules (cprs) with electronic order entry has been incorporated into required admission and discharge ehr workflow versus hospitals following umc for vte risk assessment of medically ill patients. the patient population will consist of hospitalized, medically ill (non-surgical, non-obstetrical) individuals aged \> 60 years.

investigators, plan to do a study using a pragmatic, randomized design as part of a quality improvement (qi) project as a substudy within the existing nih r18 proposal of creating a universal "smart on fhir" platform of the improve vte cpr for key northwell health hospitals. investigators, aim is to assess whether an ehr-embedded cpr for vte prevention - the improve vte cpr - ultimately tied to electronic order entry will increase the proportion of hospitalized medical patients at risk of vte who receive appropriate thromboprophylaxis, both at hospital admission and at hospital discharge, compared to umc. investigators, secondary aims are to assess whether key adverse outcomes such as symptomatic vte and hospital readmission for vte are reduced and whether health -resource utilization metrics are improved.

Eligibility criteria:
inclusion criteria: • patients with an acute medical illness and one of the following risk factors: * age \> 60 years * presence of known thrombophilia * intensive care unit (icu)/coronary care unit (ccu) stay * lower extremity paralysis * cancer * immobilization * previous vte history * d-dimer (\>2x uln) exclusion criteria: • patients with the following factors: * therapeutic anticoagulation * history of recent bleeding. * active gastroduodenal ulcer * thrombocytopenia (admission platelet count\< 75x 109 cells/l ) * coagulopathy (baseline inr \> 1.5) * severe renal insufficiency (baseline)crcl \< 30ml/min) * dual antiplatelet therapy * bronchiectasis/pulmonary cavitation * active cancer, and recent major surgery within 30 days of their index hospitalization bleeding.
bioequivalency study of 300 mg lithium carbonate under fasting conditions

Conditions: Bipolar Disorder

Summary: the objective of this study was the bioequivalence of a roxane lithium carbonate 300 mg extended release tablet formulation compared to solvay's lithobid 300 mg extended release tablet under fasting conditions using a single-dose, randomized, 2 treatment, 2-period, 2-sequence crossover design.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening. exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enzyme altering drugs. * history of allergic or adverse response to lithium, or any comparable or similar product.
the use of ambulatory blood pressure monitors to assess angiotensin converting enzyme inhibitors

Conditions: Hypertension, Resistant to Conventional Therapy

Summary: the purpose of this study is to use ambulatory blood pressure monitors to investigate whether enalapril is superior to lisinopril in managing nocturnal hypertension in patients with resistant hypertension currently treated with daytime angiotensin converting enzyme inhibitors.

resistant hypertension is defined as blood pressure \> 140/90 mm hg while adherent to three or more antihypertensive medications or \ 120/70 mm hg and "non-dipping" (night/day blood pressure \> 0.9). a higher rate of cardiovascular events occur during the "morning surge" partially attributed elevated nighttime blood pressure due to increased renin angiotensin aldosterone system (raas) activity. angiotensin converting enzyme inhibitors (aceis) suppress raas activity this prospective randomized parallel-group pilot study will occur at memorial family medicine. eligible patients will undergo three study visits over a 5-8 week span. after providing written informed consent, patients will complete an initial screening visit assessing 25 hour blood pressure using ambulatory blood pressure monitors. patients will continue the study if they are found to have a nighttime blood pressure \>120/70 mm hg. patients continuing the study will be randomly assigned to equivalent dose lisinopril or enalapril treatment arms and their administration time will be changed to "bedtime." at the final visit, patients will complete a final ambulatory blood pressure analysis to reassess nighttime blood pressure and dipping status. it's expected that patients with enalapril treatment will have superior nighttime blood pressure reduction compared to the lisinopril treatment group. if the expected outcome occurs, more patients in the enalapril group will meet their nighttime blood pressure goal (\<120/70 mm hg) and exhibit a "dipping pattern." current evidence suggests that patients with normal nighttime blood pressure and dipping pattern are at a lower risk for cardiovascular morbidity and mortality.

Eligibility criteria:
inclusion criteria: * patients with clinic blood pressure \> 140/90 mm hg on 3 antihypertensives or clinic blood pressure \< 140/90 mm hg on 4 antihypertensives * currently treated with an angiotensin converting enzyme inhibitor exclusion criteria: * chronic kidney disease (ckd) stage 4 or worse * pheochromocytoma * unstable cardiovascular disease stroke, transient ischemic attack, unstable angina, or myocardial infarction in the last 30 days * hyperaldosteronism * current pregnancy * shift worker at night * presenting blood pressure \> 180/110 mm hg

Keywords: chronotherapy angiotensin converting enzyme inhibitors ambulatory blood pressure monitoring
open lung approach versus conventional protective ventilation in obese patients undergoing open abdominal surgery

Conditions: Abdominal Surgery; Obese Patients

Summary: the purpose of this study is to compare open lung approach versus conventional protective ventilation in obese patients undergoing open abdominal surgery

after being informed about the study and potential risks. all patients giving written consent will be randomized by double blind manner into 2 groups each one containing 24 patients group spv: will be ventilated using volume controlled ventilation (7ml/kg tidal volume) with addition of 5 cm h₂o fixed peep till the end of the surgery . group ola: the patients will undergo arm followed by personalized peep.

Eligibility criteria:
inclusion criteria: * patient aged between 18 - 65 years * bmi between 30-40 kg/m² * asa i and ii,open elective abdominal surgery which is expected to last for more than 2 hours under general anesthesia and planned to be extubated at the end of surgery exclusion criteria: * emergency surgery, pregnancy, chronic obstructive pulmonary disease (fev1 \< 80% of the predicted value) * active asthma, acute respiratory distress syndrome * history of pneumothorax, lung cyst, difficult airway, obstructive sleep apnea,ischemic heart disease, heart failure * significant arrhythmias and intracranial hypertension. exposure to radiotherapy and chemotherapy within 2 months before surgery. advanced cardiovascular ,liver, renal diseases ischemic heart disease, heart failure, significant arrhythmias and intracranial hypertension

Keywords: open lung approach conventional ventilation
multidisciplinary combined exercise and nutrition intervention for sarcopenia

Conditions: Sarcopenia

Summary: this study aims to demonstrate the effect of combined exercise-nutrition intervention in old adults with sarcopenia. this study will be conducted with prospectively randomized controlled trial comparing outcome of combined exercise-nutrition intervention with conventional medical care. handgrip strength, gait speed, knee extensor muscle power, physical performance, muscle mass using dexa, quality of life, activities of daily living, sarcopenia screening questionnaire, nutritional assessment will be evaluated on baseline, 12-weeks and 24-weeks after intervention.

the definition of sarcopenia is age-related loss of skeletal muscle and physical functions. sarcopenia is emerging health problem and increases medical expenditure as the population ages. sarcopenia is closely related to chronic diseases and geriatric diseases. in particular, patients with metabolic syndrome showed a high prevalence of muscle loss and muscle weakness. it has been reported exercise in sarcopenia patients not only improved insulin sensitivity and physical performance but also helped the treatment of the diseases. also, it is recently demonstrated that combined exercise-nutrition intervention improved muscle function in elderly patients. however, there is still not established standard protocol for the combined exercise-nutrition intervention. therefore, the aim of this trial is to compare the effects of combined exercise-nutrition intervention in sarcopenia patients with multicenter, multidisciplinary, randomized controlled trial.

Eligibility criteria:
inclusion criteria: * patients older than 65 years and under 90 years * patients who meet the criteria for the asian working group for sarcopenia (awgs) 2019 * patients who had metabolic syndrome exclusion criteria: * patients with less than estimated glomerular filtration rate (egfr) 30 * patients with musculoskeletal or chronic lung disease incapable of exercise * patients with untreated or uncontrolled cardiovascular disease which may affect muscle mass or performing exercise * patients less than 5 years after treatment of malignant tumor * patients with liver cirrhosis, diabetes and other chronic disease * patients who cannot perform combined exercise nutrition intervention for other reasons

Keywords: sarcopenia older adults exercise nutrition standard intervention
influence of audiovisual aids in the preanesthetic interview

Conditions: Patient Satisfaction

Summary: 1000 patients will be asked to fill out a questionnaire about preanesthetic visit right after the interview. on a daily randomization the groups will be assigned to: group a = face-to-face interview; group b = interview plus brochure, group c= interview plus movie. evaluation of patient satisfaction und knowledge transfer will be evaluated with a questionnaire filled out right after the interview with the anesthesist.


Eligibility criteria:
inclusion criteria: * voluntary exclusion criteria: * language problems * not able to read or write * patients does not want to fill out questionnaire

Keywords: patient satisfaction preanesthesia movie brochure face-to-face interview
non-interventional study to assess the tolerability and the safety profile of scit therapy with acarovac® hausstaubmilbe

Conditions: Perennial Allergic Rhinitis

Summary: non-interventional study to assess the tolerability and the safety profile of scit therapy with acarovac® hausstaubmilbe

this prospective open multi-centre non-interventional study was initiated to document the tolerability and the safety profile of the subcutaneous allergen-specific immunotherapy with acarovac® in house dust mite allergic patients in routine medical care. during the up-dosing phase with acarovac®, patients will receive 4 injections in 1-2 week intervals with increasing allergen amount up to the individual maximum tolerable dose. after reaching the individual maximum tolerable dose patients will receive one maintenance dose in a 4 - 8 week interval. data on tolerability are documented by the physicians.

Eligibility criteria:
inclusion criteria: * patients of the age of 5 years and older suffering from a house dust mite induced allergic rhinitis exclusion criteria: * patients suffering from acute or chronic infections or inflammations * patients suffering from secondary modifications of the target organ with function impairment (emphysema, bronchiectasis) * patients suffering from severe and uncontrolled asthma * patients with a known severe autoimmune disease * patients with active malignant disease * patients requiring beta-blockers * patients having any contraindication for the use of adrenaline * patients with a hypersensitivity to the excipients of the drug
effects of scapular stabilization exercises combined with post facilitation stretch in patients with upper cross syndrome: a randomized control trial

Conditions: Upper Cross Syndrome

Summary: upper cross syndrome is characterized by the postural deviation of head , neck , shoulders and altered muscular muscular activation which included weakness of rhomboids , middle and lower trapezius and serratus anterior and tightness of upper trapezius , pectorallis and levator scapulae . it is a combinaton of scapular dyskinesia , forward head posture , rounded shoulder and thoracic kyphosis.this study aims to assess the enduring effects scapular stabilization exercises along with post facilitation stretch on upper cross syndrome with the goal of preventing its reoccurrence over time, if there are improved results by the combination of both treatments than any of them alone , then it can used in combination for better results on patients


Eligibility criteria:
inclusion criteria * aged 18 to 45 with neck pain for more than 3 months * both genders males and females * nprs scoring of greater than or equal to 4 points * no history of serious pathology or recent neck trauma * diagnosed upper cross syndrome cases using janda approach exclusion criteria * known scapular or shoulder pathology * cervical and thoracic fractures , dislocations or surgeries or whiplash injury
lung ultrasound for covid-19 initial triage and monitoring

Conditions: COVID-19; Acute Respiratory Failure; Triage; Lung Ultrasound; CT Scan

Summary: the quick study main aim is to assess the predictive value at day 1, of a model built on lung ultrasound (lus) and clinical data, both recorded at hospital admission of covid-19 patients.

initial triage assessment is the cornerstone of first-line medical management for covid-19 patients. only an accurate and fast evaluation of covid-19 patients respiratory system integrity, can allow optimal treatment care and medical resources attribution. despite its very large deployment, the use of thoracic computed tomography (ct scan) for covid-19 patients severity assessment is currently debated. actually ct-scan use in this setting: i) it is associated with risky in/out hospital patient's transport, both in terms of medical management of patient's critical conditions and risk of covid-19 nosocomial transmission, ii) risks related to x-ray exposure iii) ct-scan is a snapshot of respiratory system integrity and does not provide data that might be used for patient's monitoring. lus is a non-invasive, non-ionizing, fully bedside imaging tool. investigators team has previously contributed to the development and validation of lus for critically ill patient's management. to the extent of our knowledge, there is neither data regarding covid-19 patient's lus patterns, nor about the potential link between lus data, patient's severity and outcome. the investigators hypothesize that the combined use of lus and clinical data (q-sofa score, spio2/fio2) recorded at covid-19 patients hospital admission, will allow to accurately predict short-term outcome. the investigators expect to predict at patient's hospital admission, the patient's clinical status at 24h: favorable (spontaneous ventilation with o2 \ 6 l/min or under mechanical ventilation).

Eligibility criteria:
inclusion criteria: * adult (\> 18 years). * proven covid-19 (specific pcr from respiratory track sample) * ct scan prescribed by physician in charge, independently of research. * patients consent (or surrogate decision maker's consent in case of need). exclusion criteria: * reduction or cessation of active treatment. * patient under guardianship, tutelage measure or judicial protection * patient deprived of liberty by judicial order * no french health insurance. * pregnancy or nursing woman. * enrolled in another trial evaluating thoracic imaging.

Keywords: covid-19 acute respiratory failure triage lung ultrasound ct scan
safety and efficacy of awake uniportal video assisted thoracoscopic modified pericardial window in recurrent pericardial effusion at mid term result

Conditions: Awake Thoracoscope; Pericardial Effusion; Pericadiopleural Window

Summary: this study compare two surgical techniues at the same time two methods of anathesia with assisstance of thoracoscope for cases of repeated collection of fluid in pericardial sac and observation the result of the two techniques on the operated patients from 3 to 6 months

this study compare two thoracoscopic techniues awake modified pericardial window and pericardial window under general anasethia for cases of repeated collection of fluid in pericardial sac and observation the result of the two techniques on the operated patients from 3 to 6 months

Eligibility criteria:
inclusion criteria: * patients who presented with recurrent massive pericardial effusion based on clinical, radiological evidence by echo and c.t. chest exclusion criteria: * hemodynamically unstable patients

Keywords: pericardial effusion pericardiopleural window