Kornimate/medical-research-clean huggingface dataset:
effectiveness of vapocoolant spray on venipuncture pain in young male donors

Conditions: Venipuncture; Pain

Summary: aim: the aim of this study is to assess the effectiveness of vapocoolant spray in reducing pain related to venipuncture in young, healthy male blood donors. hypotheses: h1: vapocoolant spray reduces venipuncture pain during blood donation. h0: vapocoolant spray does not reduce venipuncture pain during blood donation.

after being informed about the study and potential risks, all patients giving written informed consent. before the procedure was begun, the donors who agreed to participate in the study were met face-to-face and asked to fill in the "informative characteristics form", the "vas", the "blood/injection fear scale" and the "stai-i" forms.then the donors were assigned to their groups by the researcher.the donors in the control group were not given any intervention during the blood collection process. vapocoolant spray was applied to the donors in the vapocoolant spray group. during the blood collection procedure, after the donors' skin was cleaned with antiseptic solution, spray was applied to the application site for a maximum of 10-15 seconds from a distance of 25 cm. in both groups, immediately following venipuncture, pain assessment was made with the vas by the researcher, who did not know which group each participant belonged to.

Eligibility criteria:
inclusion criteria: * aged between 18 and 35 * bmi between 18.5 and 24.9 kg/m2 * speaks turkish * male donor * individuals who applied to make voluntary blood donations * volunteers to participate in the study exclusion criteria: * donors who did not agree to take part in the study, * donors with open wound, scar, infection, dermatitis, eczema or lesion at the venipuncture site, or donors with cold allergy

Keywords: vapocoolant spray venipuncture pain donors
an efficacy trial of the mindfi app for stress, well-being, and sleep quality in working adults

Conditions: Stress; Burnout

Summary: 90% of asian workers report high levels of stress in an "always-on" culture. stress and burnout are risk factors that account for 10-20% of health expenditure and threaten work longevity in the world's fastest growing economies. traditional face-to-face sources of mental care such as counseling and psychotherapy are effective as a countermeasure to stress, but not always accessible or acceptable for those with busy lifestyles. because of this, there is an urgent need for on-demand, scalable interventions to reduce stress and improve mental and physical well being. technology-based solutions are increasingly being proposed to fill this need. mindfi is a smartphone app that uses mindfulness exercises to help users cope with work stress and increase productivity. since 2017, it has been featured by apple, bbc, and bloomberg and is being used at corporates such as bain, bloomberg, cigna, and zendesk. mindfi users contribute behavioral and self-report data, which are then used to generate individual recommendations for relevant, evidence-based exercises. these include mental care techniques such as mindfulness meditation, therapeutic journaling, psychosocial support and educational wellbeing quizzes. in this study, the investigators will recruit 200 participants in a randomized controlled design, with 100 receiving access to content of the mindfi app, and 100 receiving access to a version containing music tracks for relaxation. each intervention will last 4 weeks. participants will use these apps for a period of 5 weeks (for a minimum of 10 minutes per day). pre- and post-intervention, the investigators will measure self-reported ratings on a number of psychological variables, and will track sleep quality objectively for a one-week period.


Eligibility criteria:
inclusion criteria: 1. currently in full-time employment 2. fluent in english 3. dass-21 scores of at least 10 on the stress subscale exclusion criteria: 1. current diagnosis of a chronic psychological disorder, or sleep disorder 2. regularly practising meditation

Keywords: mindfulness sleep quality well-being
vancomycin and negative pressure therapy for post-sternotomy deep sternal wound infection

Conditions: Post-Sternotomy Deep Sternal Wound Infection

Summary: only a limited number of studies have been published that monitored the penetration of antibiotics from blood into exudate in patients treated with negative pressure wound therapy (npwt), and that evaluated the adequacy of current dosage regimens according to antibiotic tissue concentrations. a higher migration rate of several antibiotics (including vancomycin) to exudate has been reported in patients with skin ulcers, skin defects, burns, and traumatic wounds treated with npwt compared to patients without npwt. in the present study, the investigators will evaluate the pharmacokinetic profile and wound penetration of vancomycin in open-heart surgery patients with post-sternotomy deep sternal wound infection receiving npwt.

for this prospective observational study, consecutive patients treated with npwt for post-sternotomy deep sternal wound infection (dswi) will be enrolled. on the first day of the study, serum and exudate samples will be synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3, and 6 hours after vancomycin administration. on the following three consecutive days, additional samples will be collected, only before vancomycin administration. the ratio of average vancomycin concentration in wound exudate to serum will be observed for free (unbound) and for total (bound + unbound) concentration. the percentage of free vancomycin in wound exudate and in serum will be observed. the level of vancomycin wound penetration will be observed for three days. the total hospital stay in patients with dswi versus those without dswi will be recorded, together with the in-hospital or 90-day mortality, together with late dswi recurrence. all-cause mortality will be analyzed during a median follow-up of 2.5 years.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * clinical and laboratory signs of significant infection * indication for npwt with concomitant antibiotic therapy exclusion criteria: - none

Keywords: exudate deep sternal wound infection negative pressure wound therapy open-heart surgery vancomycin wound penetration
retrospective study about nasopharyngeal carcinoma at c. s. parc tauli

Conditions: Nasopharyngeal Carcinoma

Summary: retrospective study of patients diagnosed with a nasopharyngeal carcinoma included in our data base care between june 1990 and september 2013. our hypothesis is: our series of patients with a history of nasopharyngeal carcinoma presents epidemiological, response rates to the different treatments and survival similar to those described in the literature

retrospective study of 50 patients diagnosed with nasopharyngeal carcinoma. the following variables will be studied: age, sex, toxic habits , associated pathology, patient origin , first symptom , duration , histology, stage , second malignancies , recurrences , metastases , treatments performed , the response thereto and survival.

Eligibility criteria:
inclusion criteria: * patients diagnosed of nasopharyngeal carcinoma at ear-nose-throat department at corporació sanitària parc taulí from 1993 to 2013 exclusion criteria: * none

Keywords: nasopharyngeal carcinoma
laquinimod phase iia study in active crohn's disease

Conditions: Crohn's Disease

Summary: the study aims to evaluate the safety and clinical effect of daily oral treatment of laquinimod capsules in active moderate to severe crohn's disease. this study will assess laquinimod doses of 0.5mg /day to 2 mg/day in sequential dose groups (cohorts). laquinimod is a novel immunomodulating drug which is currently in advanced stages of development by teva pharmaceuticals ltd. for multiple sclerosis.


Eligibility criteria:
inclusion criteria: 1. subjects diagnosed with crohn's disease for at least 3 months prior to screening. 2. moderate to severe crohn's disease patients as determined by the cdai score exclusion criteria: 1. subjects who have had recent bowel surgery 2. subjects with clinically significant gi obstructive symptoms 3. subjects with a clinically significant or unstable medical or surgical condition 4. subjects with unstable doses of standard of care medications (5-asa, antibiotics, oral corticosteroids, immunosuppressants ) 5. women who are pregnant or nursing or who intend to be during the study period. 6. women of child-bearing potential who do not practice an acceptable method of birth control
denosumab (amg 162) in bisphosphonate naive metastatic breast cancer

Conditions: Breast Cancer; Metastases; Bone Metastases in Subjects With Advanced Breast Cancer

Summary: this study is to evaluate various doses and schedules for denosumab administration and characterize the safety profile in this indication.


Eligibility criteria:
inclusion criteria: - histologically or cytologically confirmed breast adenocarcinoma * at least one bone metastasis

Keywords: breast cancer cancer
trident landmark as a safe and easy method for facial nerve trunk identification during superficial parotidectomy

Conditions: Parotid Tumor; Parotid Neoplasms; Surgery; Head and Neck Disorder

Summary: the parotid has a close relationship with the extra temporal course of the facial nerve. the study aimed to evaluate the accuracy and safety of trident landmark during superficial parotidectomy in the identification of the facial nerve trunk.

a prospective study was conducted between january 2018 and january 2020 at kafr el-sheikh university hospital (kuh) and al fayoum university hospital (fuh), egypt, on 60 patients with benign parotid tumors in the superficial lobe. all patients were subjected to superficial parotidectomy. the outcome was evaluated regarding the clinical success of facial nerve identification by trident landmark and early postoperative complications.

Eligibility criteria:
inclusion criteria: * patients with benign tumors of the superficial lobe of the parotid gland exclusion criteria: * cancers * unfit patients for surgery
vitamin d and critically ill patients

Conditions: Systemic Inflammatory Response Syndrome; Sepsis

Summary: the higher rate of vitamin d deficiency is spotted among patients being hospitalized or in critical condition. especially, vitamin d level below normal prolongs hospital stay and increases incidence of adverse prognosis and pushing up mortality of a number of diseases. however, it is remain unclear the relationship between vitamin d levels and critically ill, especially infection or sepsis. in this study, the investigators evaluate the significance of vitamin d for diagnosis and other relevant assessments of icu cases, including vitamin d's relevance to sepsis, as well as its value in severity and prognosis assessment, high-performance liquid chromatography and tandem mass spectrometry was used to detect the quantification of the total 25(oh)d in serum of critically ill patients. the investigators speculate that measurement of vitamin d could be taken as an indicator for diagnosis and assessment in critically ill patients.


Eligibility criteria:
inclusion criteria: * male and female aged 18 years old and over; * entered icu; * fulfilled at least two criteria of systemic inflammatory response syndrome * core temperature higher than 38 °c or lower than 36 °c * respiratory rate above 20/min, or pco2 below 32 mmhg * pulse rate above 90/min, and * white blood cell count greater than 12,000/μl or lower than \< 4,000/μl or less than 10% of bands. exclusion criteria: * patients or their relatives refused

Keywords: vitamin d infection disease severity mortality critically ill sepsis
bpoi (berlin pediatric oxygenation index) - a new predictor for imminent failure of hfnc in children avoiding delayed niv or intubation

Conditions: Respiratory Failure (Pediatric Patients)

Summary: the investigators developed an index that integrates different flow-settings in high-flow nasal cannula (hfnc) therapy with non-invasively measured clinical parameters of oxygenation in pediatric patients. this observational study is designed to evaluate this index and to determine a cut-off value for imminent hfnc failure.

high-flow nasal cannula therapy is a broadly used instrument of respiratory support in pediatric and adult patients with respiratory failure. for adult patients with pneumonia and respiratory failure, there is a validated index (rox; ratio spo2/fio2) which helps to identify those at risks for the need of intubation. this index however is not applicable in the pediatric population because the physiological values of respiratory rate vary greatly across different ages. thus, based on the particularities of pediatric patients the investigators developed an index that integrates different flow-settings in hfnc therapy with non-invasively measured clinical parameters of oxygenation. the bpoi is defined as the ratio of the product of the peripherally measured oxygen saturation and the patient's body weight divided by the product of hfnc flow and the fraction of inspired oxygen: bpoi = (spo2 \* kg) / (flow \* fio2)

Eligibility criteria:
inclusion criteria: * patients with respiratory failure and indication für high-flow nasal cannula therapy * patients aged between 4 1/7 weeks and 18 years * patients who were treated between 01/01/2017 and 28/02/2021 in the department of pediatric pulmonology, immunology and intensive care medicine at campus virchow- klinikum, charité - universitätsmedizin berlin exclusion criteria: * patients aged between 1 and 27 days (neonatal period) * patients with congenital cyanotic heart defects * patients after or in the course of haematopoetic stem cell transplantation * patients with ambulatory respiratory support
covid19 vaccination: clinical, laboratory and cellular monitoring

Conditions: Health Care Utilization; Health Care Associated Infection

Summary: primary objective: 1. monitor adverse events (adverse event following immunization - aefi) in vaccinated subjects and analyze the associations with: (a) demographic variables and anthropometric parameters (sex, age, bmi, etc.); (b) socioeconomic-cultural variables; (c) co-morbidities. secondary objectives: 1. monitor the antibody response in vaccinated subjects and analyze the associations with: (a) demographic variables and anthropometric parameters (sex, age, bmi, etc.); (b) socioeconomic-cultural variables; (c) co-morbidities. 2. assess the quantity (antibody titer) and quality of the anti-spike immune response induced by vaccination. 3. evaluate the dynamics of the infection and the protective efficacy of the vaccine against infection / disease by studying the incidence and titre of antibodies against nucleoprotein (n) induced by natural infection; 4. evaluate the neutralizing capacity of sera vs. a panel of sera selected and analyzed in house and in in vitro microneutralization systems with live virus; 5. to evaluate the cell-mediated immune response (cmi) to vaccination against sars-cov-2 in a subgroup of vaccinees. methodology: 1. administration at baseline of a questionnaire for the collection of clinical data. 2. perform a blood sample to measure antibody response in vaccinated subjects 3. administer a questionnaire to evaluate adverse events after vaccination 4. reassess the antibody response 1 month after complete vaccination and 6 and 12 months after the start of vaccination 5. an antibody assay will be drawn in a subgroup before subjecting the subject to the vaccine. 6. in a subgroup, the blood collected will also be collected in a heparinized tube for the study of cell-mediated immunity. 7. in the event that a subject participating in the study presents during the course of the observation the positivity for the molecular research of sars-cov-2 rna to the oro-nasopharyngeal swab, a new sample will be performed and sent to the istituto superiore di sanità for the search for viral variants.


Eligibility criteria:
inclusion criteria: all subjects vaccinated or to be vaccinated at the aou policlinico umberto i and who will agree to join the study. exclusion criteria: all subjects who refuse to give consent or who have contraindications to vaccination.

Keywords: covid19 vaccine
a prospective, mono-center, interventional study evaluating the effect of one year initial care by hygieno-dietary advices with or without phlebotomy on glycemia after at least 5 years in patients with dysmetabolic iron overload syndrome

Conditions: Dysmetabolic Iron Overload Syndrome

Summary: a prospective, mono-center, interventional study evaluating the effect of one year initial care by hygieno-dietary advices with or without phlebotomy on glycemia after at least 5 years in patients with dysmetabolic iron overload syndrome

dysmetabolic iron overload syndrome (dios) is defined by a slight iron overload associated to features of the metabolic syndrome. this is a frequent condition that parallels the increasing prevalence of non alcoholic steato hepatitis. the role of iron overload on insulin sensitivity is described in large cohorts study, with an increased risk of type 2 diabetes in patients with increased serum ferritin, and in vitro where iron load alters key regulators of lipid and glucose metabolism. in patient with dios, improving diet and lifestyle is a major goal, albeit it does not allow to lower body iron stores. therefore the role of bloodletting in this setting was raised. several low quality studies suggested a beneficial effect of bloodletting on insulin resistance. our group demonstrated in a large multicenter randomized trial, the lack of beneficial effect of bloodletting over one year. because this may be a too short period of time to demonstrate a positive effect we would like to assess the long term effect of iron depletion on insulin resistance and its clinical consequence.

Eligibility criteria:
inclusion criteria: * persons who participated in the " phlebotomy " protocol: a prospective, randomized study comparing effect of phlebotomy and hygieno-dietary advices with hygieno-dietary advices only on glycemia in patients with dysmetabolic iron overload syndrome * persons affiliated to french social security * persons who received an oral and written information on the protocol and signed the informed consent form exclusion criteria: * persons subject to major legal protection (safeguarding justice, guardianship, trusteeship) since their enrolment in the "phlebotomy" protocol * persons deprived of liberty * pregnant or breastfeeding women
scheduled or as needed pain regimen?

Conditions: Pain, Postoperative

Summary: the aim of this study is to determine feasibility of a randomized controlled trial and estimates of efficacy for pain control of a scheduled pain regimen versus an as needed pain regimen for participants undergoing same day surgery procedures.


Eligibility criteria:
inclusion criteria: * any outpatient surgeries performed at cape fear valley medical center by dr. van fossen during the duration of the study, including: laparoscopic cholecystectomy, laparoscopic appendectomy, laparoscopic ventral/umbilical/incisional hernia repair, open ventral/umbilical/incisional hernia repair, laparoscopic inguinal hernia repair, open inguinal hernia repair, lumpectomy, sentinel lymph node biopsy, lymph node biopsy, mass excision skin or subcutaneous, diagnostic laparoscopy, laparoscopic lysis of adhesions, pilonidal cyst excision, hemorrhoidectomy, anal fissure/sphincterotomy, anal fistulectomy, rectal exam under anesthesia, wound debridement, and wound closure * outpatients who are medically eligible to receive the standard post surgery medication protocol (the scheduled pain protocol used in this study). * age 18-65 exclusion criteria: * participants with the following conditions will be excluded from our study: fibromyalgia, chronic pain, cancer (except for breast cancer). this is because these participants have pain at baseline and it will be difficult to discern if their pain is from surgery or their chronic condition. * participants on chronic pain medications will also be excluded from our study because it will be difficult to tell if their pain control is related to their established regimen or the one we are implementing. * if participants who are not fluent in english, because all study materials are in english. * participants with stage 3 chronic kidney disease or higher will also be excluded from the study as they cannot take ibuprofen (according to national kidney foundation), which is included in our pain regimen.

Keywords: surgery acute pain post-operative pain
hpv self-sampling for cervical cancer screening among lesbian, bisexual, and queer (lbq) women

Conditions: Cervical Cancer Screening

Summary: the proposed study will examine the implementation of a human papilloma virus (hpv) self-sampling intervention for under screened lbq women living in south florida. the study will enroll participants to receive the self-sampling intervention in community venues. the purpose of this study is to pilot the self-sampler for feasibility and acceptability within this underserved population.


Eligibility criteria:
inclusion criteria: * self-identify as lesbian, bisexual, or queer woman * assigned female sex at birth * english speaking * ages 25-65 years * report not having had a pap smear in the last three years (per uspstf guidelines) * if age 30 or over, report not having a pap smear/hpv co-test within the past 5 years (per uspstf guidelines) exclusion criteria: * report having had a hysterectomy * report having history of cervical cancer * unable to consent * pregnant women * prisoners
the imaging genetic study of schizophrenia and family

Conditions: Schizophrenia

Summary: to investigate the brain abnormalities and the association with gene in schizophrenia patients and their relatives.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of schizophrenia（dsm-iv） * total score of panss\>64 exclusion criteria: * other psychiatric disease, * organic disease * neurological disease * unstable physiological status * age\>65 * pregnant
perioperative administration of pregabalin in patients undergoing arthroscopic anterior cruciate ligament reconstruction

Conditions: Postoperative Pain Management

Summary: to prove pregabalin's efficacy and safety in thai patients scheduled for arthroscopic acl reconstruction

only eligible patients with willingness to join this study are included. eligible patients are those aged 18-65 years of either sex, american society of anesthesiologists (asa) physical status i \& ii, and body mass index (bmi) between 16-35. the exclusion criteria are patients who are allergic to pregabalin, with impaired hepatic and renal functions, alcohol or substance abuse, chronic pain (except pain in the knee joint) or daily intake of analgesics, uncontrolled medical disease (hypertension and diabetes mellitus) and inability to operate patient-controlled analgesia (pca) device. data analysis * student t-test for continuous data with normal distribution * mann-whitney u test for continuous data with non-normal distribution * chi-square test for categorical data

Eligibility criteria:
inclusion criteria: * eligible patients are those aged 18-65 years of either sex, * american society of anesthesiologists (asa) physical status i \& ii, and body mass index (bmi) between 16-35. exclusion criteria: * patients who are allergic to pregabalin, * impaired hepatic and renal functions, * alcohol or substance abuse, * chronic pain (except pain in the knee joint) or daily intake of analgesics, uncontrolled medical disease (hypertension and diabetes mellitus) * inability to operate patient-controlled analgesia (pca) device

Keywords: perioperative pregabalin arthroscopic anterior cruciate ligament reconstruction postoperative pain management