Kornimate/medical-research-clean huggingface dataset:
cycling of sedative infusions in critically ill pediatric patients

Conditions: Respiratory Failure

Summary: the purpose of this study is to determine if the reduction of the total amount of sedative critically pediatric ill patients receive in the picu will achieve a significant decrease in mechanical ventilation days and a decrease in the overall length of stay in the picu and hospital.

continuous sedative infusions have been associated with longer duration of mechanical ventilation, longer stay in the intensive care unit (picu) and total hospital stay. also, extended duration of continuous sedative infusions limits the ability to assess for adequate neurologic function. there is, however, no published data on the use of daily interruption of continuous sedative infusions in pediatric patients, nor are there any recommendations from the leading pediatric critical care groups regarding this issue. infants and children exposed to noxious stimuli (endotracheal tube, endotracheal suctioning, mechanical ventilation, indwelling catheters) in addition to an unknown environment are less likely to cooperate during normal daily interventions in the picu. continuous infusions of benzodiazepines and opioids in addition to as needed (prn) bolus doses have been the standard of care in our institution for mechanically ventilated patients. the study seeks to determine if reducing the total dose of sedatives, by holding them in a cyclical manner, will be a safe and effective intervention that will not increase adverse patient outcomes. this will be achieved by limiting the patient tolerance to the sedatives, decreasing the body total deposit of sedatives and subsequently decreases awakening time when patient is ready for extubation.

Eligibility criteria:
inclusion criteria: * less than or equal to 18 years of age * intubated and mechanically ventilated * expected to require continuous infusions of sedatives for at least 48 hours * parent or legal guardian available for informed consent * males and females of any race are eligible exclusion criteria: * less than 72 hours after surgery * cyanotic heart disease with unrepaired or palliated right to left intracardiac shunt * critical airway (according to picu attending) * ventilator dependent (including noninvasive) on picu admission * greater than 48 hours of continuous sedation infusion(s) * neuromuscular respiratory failure * managed by patient controlled analgesia (pca) or epidural catheter * known allergy to any of the study medications (fentanyl or midazolam) * family/medical team have decided not to provide full support (patient treatment considered futile) * patient requires ecmo * head trauma requiring intracranial pressure monitoring * pregnancy * following resuscitation from cardiorespiratory arrest whose initial ph is \< 6.9 * icu attending judgment that patient should be excluded for safety reasons

Keywords: sedation cycling pediatric
observational study on the variation of ascorbic acid in patients undergoing solid organ transplantation

Conditions: Transplantation; Ascorbic Acid Deficiency

Summary: the objective of this observational clinical study is to evaluate the variations in ascorbic acid during the transplantation phases and how these variations influence the oxidative status and patient outcome. the main questions it aims to answer are: * how many patients arrive at the transplant in a state of hypovitaminosis c? * how does hypovitaminosis c affect the patient's oxidative status? * how does hypovitaminosis c affect the length of stay in intensive care and post-transplant complications?

researches will compared: differences between hypovitaminosis group and normal range group changes in oxidative stress markers before and after solid organ transplantation incidence of allograft dysfunction between groups incidence of acute kidney injury and other complications between groups

Eligibility criteria:
inclusion criteria: * adult patients undergoing solid organ transplantation (liver or kidney or lung) exclusion criteria: * minor patients * multi-organ transplantation

Keywords: transplantation ascorbic acid oxidative stress primary graft dysfunction
the correlation of cox-2 expression in human polymorphonuclear leukocytes/macrophages (pmnl/mp) and postoperative pain

Conditions: Post-Operative Pain

Summary: to investigate the dose-effect relations among the expression of cox-2 in polymorphonuclear leukocytes (pmnl) and macrophages, systemic and local inflammatory response and postoperative pain

we detect cox-2mrna, cox-2 protein expression in inflammatory cells and pge2 concentration in patients with abdominal surgery. the differences of cox-2 expression in pmnl are compared between peripheral blood and partial incision transudate to the same individual, and at the same time, the cox-2 expression differences in pmnl and macrophages, and pge2 concentration in partial incision transudate also compared interindividually, to show the relevance between the difference and postoperative pain. in addition, the effects of parecoxib sodium on cox-2 expression of the amount in pmnl and macrophages are investigated during the development of postoperative inflammatory pain. finally, we will clear the dose-effect relations among the expression of cox-2 in inflammatory cell, systemic and local inflammatory response and postoperative pain.

Eligibility criteria:
inclusion criteria: * the trial is approved by tongji hospital's ethics committee, tongji medical college of huazhong university of science and technology, and is registered through clinical trail. all patients give written informed consent * american society of anesthesiologists (asa) physical status of i or ii * 20 years to 55 years * weight 50 \~ 70 kg, bmi 19 \~ 24 * duration of operation time in the range of 2-4 hours * a normal leukocytes level before the operation * no alcohol or smoking abuse * without major trauma, history of psychiatric disease and history of chronic pain * patients agreement with the trial and having ability to complete the requirements of this study * patients receiving intravenous patient controlled analgesia (pca) exclusion criteria: * allergy or contraindication to selective cox-2 inhibitors * received nsaids treatments before the operation * used enzyme inhibitor (such as ketoconazole, fluconazole, itraconazole), enzyme inducer (such as rifampicin, phenytoin sodium, carbamazepine, dexamethasone), anticoagulant (such as warfarin, aspirin) and other drugs which increase the drug toxicity (such as erythromycin, clarithromycin, cyclosporin ciclosporin, ace inhibitor or diuretics, lithium) from the first 3 days before the operation to postoperative observation period * blood transfusion, hemodilution measures in the operation * infection of the incision

Keywords: cox-2 pmnl pain macrophages nsaids
skin to adductor canal distance in various positions

Conditions: Knee Arthritis

Summary: to control pain after total knee replacement surgery a catheter (tubing) is sometimes inserted into an anatomic space containing nerves that provide sensation to parts of the knee. this space is called the adductor canal. the catheters often stop working before we remove them for unclear reasons. the investigators think this is because the catheters become dislodged from where it was meant to be. this could be due to repeated movements of the catheter tip brought on by patients contracting their leg muscles when they ambulate or perform physio. the investigators want to confirm this by measuring the distance from a fixed spot on the patient's thigh to the adductor canal using an ultrasound machine. the leg will be measured in various positions to simulate muscle movements. a significant change in the distance could possibly contribute to catheter dislodgement and result in catheter failure.


Eligibility criteria:
inclusion criteria: * patients over or equal to the age of 18 years old who can understand the study protocol and are able to give consent * patients must be undergoing a primary total knee arthroplasty with neuraxial anaesthesia exclusion criteria: * patients with an allergy to ultrasound transducer gel or measuring tape

Keywords: total knee arthroplasty adductor canal block
protonics knee brace versus hamstring resisted exercise (hre) on individuals with patellofemoral pain syndrome

Conditions: Patellofemoral Pain Syndrome

Summary: protonicstm knee brace has been suggested as an intervention for patients with patellofemoral pain syndrome (pfps). however, the effectiveness of this knee brace compared to traditional conservative methods knee rehabilitation is lacking. the objective of this randomized controlled trial was to compare the effect of protonicstm knee brace vs. sports cord on knee pain and function in patients with pfps.

the purpose of this graduate student research study was to compare the effect of protonicstm knee brace vs. sports cord on knee pain and function in patients with pfps. design: randomized controlled trial. setting: loma linda university. participants: subjects with patellofemoral pain will participate in the study. intervention: subjects will be randomized to one of two treatment groups, the protonicstm knee brace or the sport cord to complete a series of resistance exercises over the course of 4 weeks. main outcome measures: both groups will be evaluated according to the following clinical outcomes: anterior pelvic tilt (apt), hip internal/external rotation, and iliotibial band flexibility. the following functional outcomes were also assessed: global rating of change (groc) scale, the kujala score, the numeric pain rating scale, and the lateral step-down test.

Eligibility criteria:
inclusion criteria: * subjects will be males and females who have patellofemoral pain symptoms for more than 1 month, have pain level ≥ 3 on a numeric pain rating scale, and pain during at least 2 activities, such as squatting, ascending/descending stairs, and/or running. exclusion criteria: * subjects will be excluded if they have previous traumatic injuries to the knee joint/lower limbs, sign, and symptoms of meniscus tear or ligamentous-related pathology, neurological disorders and being on pain medication."
a trial on probiotics in preventing hirschsprung's disease associated entercolitis

Conditions: Probiotics; Hirschsprung's Disease Associated Enterocolitis

Summary: enterocolitis(ec) is the most common and serious postoperative complication of hirschsprung's disease(hd) with high morbidity and mortality. probiotics are live microbes that, when administered in adequate amounts, confer health benefit to the host.based on this previous knowledge on the beneficial effects of probiotics during pro-inflammatory conditions of the gastrointestinal tract, investigators hypothesized that oral probiotics could decrease the incidence and severity of hirschsprung's disease associated enterocolitis(haec).investigators conducted a prospective, multicenter, randomized and controlled trial to assess whether oral probiotics could decrease the incidence and severity of hirschsprung's disease associated enterocolitis(haec).


Eligibility criteria:
inclusion criteria: the inclusion criteria consists of all patients suffering from hd at an age of less than 13 years old, and hd is confirmed by postoperative pathological examination, barium enema and anorectal manometry. exclusion criteria: * age\> 13 years old * patients are complicated with mental, neurological disorders (such as hypoxic-ischemic encephalopathy, epilepsy and dementia) or can not thrive. * patients are complicated with congenital gastrointestinal malformations (such as anal stenosis, intestinal atresia stenosis), metabolic and endocrine diseases caused by organic constipation and functional constipation in children. * children are complicated with liver, kidney dysfunction, blood disorders, immune deficiency diseases and significant ecg abnormalities. * children have taken oral antibiotics, microecological modulator, yogurt, other gastrointestinal motility drugs which can affect the gut flora. * drug allergies, or allergic diseases.. * poor compliance with oral probiotics treatment.
dietary approaches to stopping hypertension (dash) mobile app pilot

Conditions: Hypertension

Summary: the enormous burden of hypertension (htn) creates a need for effective, scalable, low risk interventions. the dash program of diet and exercise based lifestyle change is the most well-established, evidence-based behavioral intervention to control htn. its recommendations are central to htn control national guidelines and consumer health products aimed at behavioral management of htn. however, translating these recommendations into population-wide, inexpensive, sustainable programs have to date proven largely unrealized. the objective of the proposed study is to determine the efficacy of a htn intervention behavior change platform, 'dash mobile', in which patients with htn receive counseling about the dash diet, physical activity and htn related behaviors from health coaches trained in evidenced-based behavioral counseling methods. dash mobile has two primary components: 1) a smartphone app that captures patients' behavioral data using intuitive self-tracking for dash diet intake and bluetooth wireless sensors for blood pressure, weight and physical activity and 2) a web-based coaching portal through which health coaches view and respond to patients' behavioral data and assist them in setting goals for changing behaviors consistent with their htn behavior change plan. we aim to conduct a pilot trial of 30 htn patients to determine improvement from baseline to 3-month follow-up in physiological (blood pressure, weight); behavioral (diet \& physical activity); and psychological (e.g., quality of life) measures over a 3-month intervention. completing this research will result in preliminary feasibility and efficacy data for a larger randomized efficacy trial.


Eligibility criteria:
inclusion criteria: * hypertension * prehypertension * smartphone * english speaking exclusion criteria: * on more than 1 medicine for hypertension * live outside boston metro area

Keywords: mhealth hypertension mobile smartphone diet lifestyle bluetooth physical acitvity behavior change motivational interviewing
the expression of circankrd36 as a new biomarker of diabetic nephropathy

Conditions: Diabetic Nephropathy

Summary: 1. to evaluate expression levels of circankrd36 in the development and progression of dn. 2. to investigate correlation between expression levels of circankrd36 and stages of dn. 3. to investigate correlation between expression levels of circankrd36 and pro-inflammatory cytokine (tnf-α and il-6) in t2dm patients with ckd.

type 2 diabetes mellitus (t2dm) is one of the most common metabolic disorders that's become a global health burden affecting 463 million people worldwide according to the international diabetes federation (idf). diabetic nephropathy(dn) is one of the most common secondary complications of dm and is becoming a major cause of morbidity and mortality among diabetic patients . dn is a microvascular complication occurring in approximately 20-40% of patients with t2dm . dn has been described as a glomerular disorder with the following phases: glomerular hyperfiltration, incipient nephropathy, microalbuminuria, overt proteinuria and end-stage renal disorder. microalbuminuria is the gold standard for the early diagnosis of dn. however, many studies have suggested that it is inadequate and has some drawbacks. recent novel biomarkers have been accepted for early diagnosis and progression of dn in patients with t2dm . renal cells are capable of synthesizing pro-inflammatory cytokines such as tumor necrotic factor-alpha (tnf-α), interleukin-1β (il-1β) and interleukin-6 (il-6), these cytokines acting in a paracrine or autocrine manner that leading to the development and progression of several renal disorders .circular rnas are class of endogenous non coding rnas and are associated with numerous diseases like t2dm. circular ankyrin repeat domain 36 (circankrd36) involved in t2dm and inflammation-associated pathways via interaction with mirnas, including hsa-mir-3614-3p, hsa-mir-498, and hsa-mir-501-5p. the expression of circankrd36 was upregulated in peripheral blood leucocytes and was correlated with chronic inflammation in t2dm. therefore, circankrd36 can be used as a potential biomarker for screening chronic inflammation in patients with t2dm.

Eligibility criteria:
inclusion criteria: * patients diagnosed as type 2 diabetes mellitus exclusion criteria: * any other clinically systemic acute or chronic inflammation disease/s. * autoimmune disease. * any endocrine disease other than t2dm. * cancer. * chronic hepatic or renal failure.
the correlation of surgical colorectal cancer specimen pathology with the fluorescence of photodynamic diagnostics

Conditions: Colorectal Cancer; Photodynamic Diagnosis

Summary: this will be a pilot study involving 5 patients diagnosed with colorectal carcinoma and treated with pre-operative chemotherapy and external beam radiation therapy at the jewish general hospital, whom will very soon undergo surgery. participants will be sensitized by the instillation of a 250 ml enema containing 1.6 mmol of hal. the enema will be administered with a plastic tube with an inflatable blocking balloon to prevent leakage of the enema. fluorescence sigmoidoscopy will be performed with white light then blue excitation light after retention of the enema for 60 minutes, followed by a rest time of up to 30 minutes before rectoscopy. red fluorescence should be induced by illumination with blue light. pictures with and without fluorescence will be taken. the patients will undergo a colectomy (partial or complete) within the next 2-3 days and the surgical specimens will be collected for further fluorescence microscopy studies and pathological correlation of fluoresce with malignant pathology/histology as the gold standard. the total concentration of porphyrins in the patients' urine and serum will be recorded before sensitization, immediately after sensitization (instillation of the enema), and approximately 24 hours after sensitization. the patients' pre-and-post operative liver function tests will be measured. adverse events will be reported by direct questioning of all patients with regards to photosensitivity and gastrointestinal symptoms (nausea, vomiting), and by measuring blood pressure and heart rate. our objectives and endpoints are: 1) to determine if fluorescence with photodynamic diagnostics is selective for colorectal cancer, 2) to determine if photodynamic diagnostics has the potential to improve the detection of malignant cell after neoadjuvant chemotherapy and radiation, and 3) to determine if photodynamic diagnostics can provide an accurate depiction of the extent of disease burden not visible with normal white light sigmoidoscopy to the naked human eye.


Eligibility criteria:
inclusion criteria: * patients older than 18 years of age with diagnosed colorectal cancer. * colorectal cancer patients treated with chemotherapy and external beam radiation therapy exclusion criteria: * 1) liver cirrhosis * 2) acute or chronic hepatitis * 3) elevated liver function tests of unknown etiology with elevation of transaminases of more than 3 times normal levels * 4) known porphyria * 5) pregnancy * 6) expected lack of compliance

Keywords: fluorescence sigmoidoscopy pdd photodynamic diagnosis
suction cups and foam roller in the improvement of the flexibility in basketball players

Conditions: Flexibility, Waxy

Summary: introduction. basketball is a predominantly anaerobic exercise that exposes to high intensity actions (jumps, speed control, accelerations and decelerations, and changes of direction). a lack of flexibility can affect the appearance of muscle injuries. foam roller is a myofascial self-release technique using a foam roller. the suction cups are an instrumental technique where the negative pressure produces an increase in the blood flow of the tissues. goals. to evaluate the effectiveness of a physiotherapy intervention through suction cups and foam roller in amateur basketball players. study design. randomized, single-blind clinical study with a follow-up period. methodology. the 20 basketball players that are expected to be recruited will be randomly assigned to the two study groups: experimental (suction cups and foam roller) and control (foam roller). the intervention will last 4 weeks, with 2 weekly sessions. the study variable will be: hamstring flexibility (measured with finger-ground, well and shober tests). the analysis of normality will be carried out with the shapiro-wilk test. in case of homogeneity of the groups, we will use parametric tests: t-student test of repeated measures (difference between evaluations) and anova of repeated means (intra and intersubject effect). expected results. an intervention using suction cups and foam roller is effective in improving the flexibility of the hamstring muscles in basketball players.


Eligibility criteria:
inclusion criteria: * age between 18 to 25 years * amateur basketball players * belong to the celeste club * not having any injury to the hamstring musculature at the time of the study exclusion criteria: * at the time of the study they are included in a program of individualized strength training in lower limbs * subjects with alterations in venous return or congenital coagulopathies * subjects who present hypermobility * not signed the informed consent document

Keywords: cupping therapy foam roller basketball flexibility hamstring
can a low-threshold check-up motivate older people to schedule a dental visit?

Conditions: Oral Disease

Summary: there is little research on the effect of oral screening campaigns for improving oral health in older people. therefore, the aim of this study is to investigate the effect of a low-threshold contact with an oral health professional, including an oral health examination, on dental attendance of older people (65 years of age or older).

the intervention group will be provided with tools to facilitate dental contact and will be informed about the importance of regular dental visits. participants are given the opportunity to receive an oral examination. afterwards, each participant will receive brochures with oral hygiene instructions to take home. participants will receive information about any identified oral pathology. a referral letter for the dentist and a report for the general practitioner will also be prepared to increase social influence. if the participant doesn't have a dentist, the participant will receive a list of contact information for dentists in the area. in the control group, no oral examination will be performed. however, participants will be given a list of nearby dentists and flyers with oral hygiene instructions. in this way, we want to find out whether the presence of a dental professional with tailored advice is crucial to motivate an elderly person to good oral care.

Eligibility criteria:
inclusion criteria: * 65 years of age or older * home-dwelling within the selected regions (elz rits en elz scheldekracht) * dutch speaking * no dental check-up in the last 12 months * sufficient cognitive ability to answer the questions exclusion criteria: - failure to meet inclusion criteria
efficacy and safety of pimecrolimus cream 1% in patients ≥ 3 months of age with mild or moderate atopic dermatitis

Conditions: Atopic Dermatitis

Summary: to evaluate the efficacy and safety of pimecrolimus cream 1% in its registered indication (treatment of patients \> 3 months of age with mild to moderate atopic dermatitis) this study is not enrolling patients in the united states.


Eligibility criteria:
the patient population must consist of male or female outpatients, age ≥3 months old with mild to moderate atopic dermatitis (iga ≥ 1). exclusion criteria are pregnancy, having active viral infections at the site(s) of treatment, presenting with systemic malignancy or active lymphoproliferative diseases/disorders, receiving phototherapy or immunosuppressive therapy, having used tacrolimus ointment and known allergy or hypersensitivity.

Keywords: atopic dermatitis, eczema, mild to moderate, children, iga