Kornimate/medical-research-clean huggingface dataset:
third-generation egfr-tki treatment in metastatic egfr-mutant nsclc

Conditions: Third-generation TKI; NSCLC (Advanced Non-small Cell Lung Cancer)

Summary: the goal of this observational study is to explore the feasibility of stereotactic radiotherapy (srt) as consolidation therapy for patients with advanced non-small-cell lung cancer who were treated with third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (egfr-tki). the investigators plan to explore the time to achieve the best response after egfr-tki treatment, the characteristics of the distribution of lesions when the best response is achieved, the feasibility of srt when the best response is achieved, and the phenotype of disease progression after egfr-tki resistance. in summary, this study will provide critical information for exploring the feasibility and optimal design of srt as consolidation therapy for advanced nsclc patients treated with third-generation egfr-tki, which will further promote the optimization of comprehensive treatment for egfr-mutant advanced nsclc.


Eligibility criteria:
inclusion criteria: * pathologically confirmed non-small cell lung cancer; * clinical stage iv (ajcc, 8th edition, 2017); * egfr sensitizing mutations (l858r or 19del); * age≥18 years old; * kps score≥70; * complete systemic imaging (including brain mri) before third-generation egfr-tki treatment; * received standard third-generation egfr-tki therapy (monotherapy or combined with brain radiotherapy); * willing to cooperate with the follow-up after third-generation egfr-tki treatment; * informed consent of the patient. exclusion criteria: * multiple primary or metastatic tumors (except early skin cancer, cervical carcinoma in situ that has been treated radically, with no recurrence or progression for more than 5 years); * pregnant or lactating women who, as judged by the investigator, were not candidates for brain mri; * uncontrolled epilepsy, central nervous system disease, or history of mental disorders, judged by the researcher to potentially interfere with the signing of the informed consent form or affect patient compliance.; * patients without egfr sensitive mutations or with unknown egfr mutation status. withdrawal criteria * the investigators considered that the patients had poor adherence to the study protocol. * the patient withdrew informed consent and asked to withdraw. * there was any safety reason (adverse event) considered by the investigator; * due to other underlying diseases, side effects, economic factors, and other reasons, patients did not receive regular doses of third-generation egfr-tki (continuous withdrawal time more than 1 week, cumulative withdrawal time more than 2 weeks, etc.). * the patient was not followed up according to the protocol. * other circumstances in which withdrawal from the study was deemed necessary by the investigator.

Keywords: nsclc egfr
endoscopic tattooing and colorectal cancer

Conditions: Safety and Efficacy of Tattooing Substance

Summary: endoscopic tattooing to facilitate colorectal lesions' identification during laparoscopic surgery is a reliable and widely used technique. india ink is the standard option for colonic tattoing. different studies have been reported significant complications, of which the most common is peritonitis, due to ethylene glycol, phenols and animal-derived gelatine contained in the ink. this local inflammatory reaction is the principal reason of the formation of the adhesions detected during the laparoscopy, that make the intervention more difficult. to prevent infection or inflammatory local reaction india ink solution has to be sterilized and diluted, a cumbersome process. in the last years wide diffusion of another endoscopic ink, sterile carbon particle suspension, has reduced these complications. sterile carbon particle suspension is a prepackaged, sterile, fda-approved formulation of pure carbon particle in suspension, that eliminates the need for preinjection preparation. in an attempt to evaluate safety and efficacy of endoscopic tattooing in colorectal surgery using two different types of ink, a randomized clinical trial has been designed. two types of endoscopic ink were evaluated: sterile carbon particle suspension (experimental group) and india ink (control group) and.


Eligibility criteria:
inclusion criteria: histologically confirmed malignancy planned for an elective, segmental laparoscopic colectomy. exclusion criteria: emergency surgery open surgery immune depressant disease immune depressant medication
a study to compare the pharmacokinetics and the safety between a fixed-dose combination administration of "br3005" and co-administration of "br3005-1" and "br3005-2" under fed conditions in healthy adult volunteers

Conditions: Type2 Diabetes Mellitus

Summary: the objective of this clinical study is to compare the pharmacokinetics and the safety between a fixed-dose combination administration of "br3005" and co-administration of "br3005-1" and "br3005-2" under fed conditions in healthy adult volunteers


Eligibility criteria:
inclusion criteria: * those who have body mass index (bmi) within the range of 18.0 to 30.0kg/m² at screening visit * in case of a male subject, those who weigh 50 kg or more * in case of a female subject, those who weigh 45 kg or more * those who sign written consent spontaneously after listening to and understanding sufficient explanation of the purpose and contents of this clinical trial, characteristics of the investigational products, expected adverse events, etc. exclusion criteria: * those who have taken drugs that induce and inhibit metabolizing enzymes such as barbiturate within 30 days prior to the first day of administration or have taken drugs concerned about affecting this clinical trial within 10 days prior to the first day of administration. (however, participation is possible considering pharmacokinetics and pharmacodynamics such as interaction of investigational products, half-life of concomitant drugs, etc.) * those who have participated in other clinical trials(including bioequivalence tests) and administered their investigational products within 6 months prior to the first administration date.(however, the termination for participation in other clinical trials are based on the last administration date of their investigational products) * those who have a medical history of gastrointestinal surgery or gastrointestinal diseases that may affect the absorption of drugs. (except for simple appendectomy, hernia surgery) * in the case of a female subject, those suspected pregnancy, pregnant woman, lactating woman.
the association of ferrtin and homocysteine etc. with ri and ms in polycystic ovary syndrome (pcos)

Conditions: Polycystic Ovary Syndrome

Summary: the purpose of this study is to study the association of serum ferritin and homocysteine levels with insulin resistance and metabolic syndrome in women with polycystic ovary syndrome the polycystic ovary syndrome (pcos) is a common endocrine disease, affecting 5-10% of women with reproductive age. insulin resistance and metabolic disturbance are well-known long-term consequence of women with pcos. recent evidence suggests that increased body iron might be involved in the pathogenesis of insulin-resistance disorders, furthermore, hyperhomocysteinemia is associated with an increased risk of atherosclerotic and thromboembolic disorder. the investigators plan to retrospectively review the medical records of female patients who visited the reproductive endocrinology clinic at the wan fang medical center at taipei medical university from jan 1, 2008, to november 30, 2011.


Eligibility criteria:
inclusion criteria: * female patients who had been performed with fully pcos-related survey who visited the reproductive endocrinology clinic at the wan fang medical center at taipei medical university from jan 1, 2008, to november 30, 2011. exclusion criteria: * women who had been diagnosed with disorders of the uterus (e.g., asherman's syndrome, mullerian agenesis), and chromosomal anomalies (e.g., turner syndrome) * women who had menopause * women with inadequate clinical/biochemical records * women who had had ovarian cysts or ovarian tumors * women who took hormone, medicine for diabetes and/or cardiovascular disease.

Keywords: pcos ferritin homocysteine insulin resistance metabolic syndrome
acs-nsqip calculator for liver surgery

Conditions: Liver Surgery; Hepatectomy; Outcome After Hepatectomy

Summary: the american college of surgeons national surgical quality improvement program's (acs-nsqip) calculator has been endorsed by the surgeons' community to counsel patients and relatives regarding estimated postoperative complications. however, it does not include organ-specific risks. the aim of this study was to assess the acs-nsqip calculator's ability to predict complications, mortality and length of stay (los) in patients undergoing hepatectomy for liver tumors

this is an observational retrospective study conducted in a tertiary-referral university hospital. an established classification of complications, including post-hepatectomy insufficiency and bile leak, was adopted. the endpoint was the rate of complications, mortality and los as expected by the acs-nsqip calculator and as observed within 90-day after surgery.

Eligibility criteria:
inclusion criteria: * any patient who underwent surgery for a liver tumor at our institution between the defined period of time exclusion criteria: * any patient with missing data
validation of structured light plethysmography: asthma

Conditions: Asthma

Summary: validation of structured light plethysmography (slp) in patients with asthma, in patients with acute asthma; an observational study in healthy participants and during patients' clinical investigation of broncho-reversibility in the asthma groups.

a non-randomised observational study to validate structured light plethysmography in three groups of participants: those with stable asthma and those with acute asthma, who are undergoing routine clinical investigation of broncho-reversibility using spirometry. we will also observe a normal healthy group who will receive no clinical intervention. slp data capture and spirometry (as part of the patients clinical care) will be performed before and after a bronchodilator reversibility test which is part of the patients normal clinical care (except in the normal healthy group where no bronchodilator will be given). the data collected from this study will allow us to examine the effect of bronchodilators on breathing patterns in these patients and also compare breathing patterns in asthma patients to those in healthy individuals. the participant will wear a plain white t-shirt. alternatively, the measurement can be taken on bare skin or with the participant (if female) wearing a plain material white bra. the participant is asked to sit down on a chair or lie down with their neck in a neutral position and their back as straight as possible in front of the slp device (thora-3di, pneumacare ltd). the projector is lined up to project the grid of light over the participant's chest and upper abdomen. and will be instructed to perform a period of 5 minutes of tidal breathing, they will otherwise be asked to remain as still as possible throughout the measurement. during the sequence of breathing, thoracoabdominal wall movements will be captured by the device. participant on completion of their bronchodilator challenge within the lung function department or clinic the slp measurement is repeated on completion of their bronchodilator reversibility test within the lung function department or clinic.

Eligibility criteria:
inclusion criteria: * aged between 2 and 80 years exclusion criteria: * patients with significant co morbidities resulting in clinical instability (assessed by the clinician at screening only): * obstructive sleep apnea, apnoea hypopnoea index \> 30 (if known) * an acute or chronic condition that, in the investigator's opinion, would limit the patient's ability to participate in the study * bmi \> 40 * inability to consent/comply with trial protocol

Keywords: acute asthma,
covid-19 contact study by antigen detection test

Conditions: SARS-CoV Infection

Summary: stopping the sars-cov2 spread is essential to control the pandemic cause by this virus. a great effort is being made to carry out surveillance, case detection and contact control protocols in order to detect and isolate those contagious subjects. since both symptomatic and asymptomatic subjects can be contagious, a surveillance system based on the presence of symptoms is not enough, requiring to perform diagnostic tests in a large number of subjects, such as asymptomatic contacts or high-prevalence populations, and repeatedly. moreover, the speed in obtaining results is crucial in order not to delay the isolations of positive subjects. the polymerase chain reaction (pcr) is an expensive test which requires specialized equipment and personnel with a delay in results of 24-48 hours. in addition, its high sensitivity can mean that subjects without infective capacity have a positive result. in contrast, antigen detection tests (adts) are cheap and easy to perform, having a result in few minutes. they have shown high sensitivity and specificity in symptomatic subjects, specially in the first week of symptoms when the viral load is high. this could be very useful for the study of asymptomatic contacts to detect those with potential contagiousness quick, easily and cheaply. however, there is no evidence to support the use of adts in this group of subjects. for this reason, the investigators propose to carry out a study to compare the diagnostic efficacy of adts versus pcr in the group of subjects considered to be close contacts of sars-cov2 positive patients in the health area of cáceres.


Eligibility criteria:
inclusion criteria: * subjects considered close contacts of covid-19 patients according to the definition of the ministry of health of spain at the time of inclusion. exclusion criteria: * subjects who do not obtain their informed consent for the study. * symptomatic subject at the time of inclusion.

Keywords: antigen detection tests diagnostic efficacy contact study asymptomatic contacts
optimizing stress ulcer prophylaxis practices and reducing associated costs in intensive care units: a nonrandomized controlled study

Conditions: Stress Ulcer

Summary: the study is a prospectively designed, nonrandomized controlled study. it was conducted for six months at the eicu and gicu of a training and research hospital between 1 jun 2023 and 1 december 2023.

the study involved gicu patients as the standard care services observation group (og). the use of sup in the gicu was only monitored and noted. in the eicu, patients were identified as part of the recruiting guideline group (gg), and in addition to receiving usual care, they were managed for sup according to the ashp sup guidelines \[1\]. the study duration was six months concurrently in the eicu and the gicu. before inclusion, written informed consent was obtained from each patient or their parent(s)/legal guardian(s). subjects with incomplete data were excluded. the inclusion criteria were patients aged ≥18 years and hospitalized for ≥24 hours in the eicu/gicu. patients with a history of stomach cancer, admission to the icu because of gi bleeding, subtotal/total gastrectomy, or receiving a proton pump inhibitor for therapeutic purposes were excluded from the study.

Eligibility criteria:
inclusion criteria: * the inclusion criteria were patients aged ≥18 years and hospitalized for ≥24 hours in the eicu/gicu. exclusion criteria: * patients with a history of stomach cancer, admission to the icu because of gi bleeding, subtotal/total gastrectomy, or receiving a proton pump inhibitor for therapeutic purposes were excluded from the study.

Keywords: guidelines adherence stress ulcer intensive care
the role of cerebral oximetry in pediatric concussion assessment

Conditions: Concussion, Brain; Concussion, Mild; Traumatic Brain Injury

Summary: the purpose of this study is to determine whether there is a difference in cerebral oxygenation as measured by near-infrared spectroscopy (nirs) in children with concussion and healthy controls.


Eligibility criteria:
inclusion criteria: all participants * age 10-18 years at time of visit concussion group * present to jhh ped within the first 24 hours following trauma. * diagnosis of concussion as defined by the 3rd international conference on concussion in sport (mccrory), including the presence of any one or more of the following: 1. symptoms (ie. headache, neck pain, nausea/vomiting, dizziness, blurred vision, balance problems, sensitive to light, sensitivity to noise, feeling slowed down, feeling in a fog, difficulty concentrating, difficulty remembering, fatigue, confusion, drowsiness, more emotional, irritability, sadness, nervous) 2. physical signs (ie. loss of consciousness, unsteadiness) 3. impaired brain function (ie. confusion) * glasgow coma score of 13-15 upon arrival to jhh ped. * loss of consciousness of less than 15 minutes (if applicable). * no structural intracranial injuries identified on neuroimaging (if completed). exclusion criteria all participants * history of prior concussion or traumatic brain injury within preceding 6 weeks. * history of prior intracranial disease or mass (ie. tumor, intraventricular hemorrhage, etc.) * presence of intracranial hardware. * complaints of respiratory distress, tachypnea or hypoxia, which may affect regional cerebral oxygen saturation. * inability to stand secondary to lower extremity disease or trauma, which is required for completion of scat2. * inability to complete scat2 questionnaire secondary to developmental delay. * child in foster care or legal guardian not available. * participant known to be pregnant, which alters total body blood flow and likely affects regional cerebral oxygen saturation. * non-english speaking.

Keywords: near infrared spectroscopy pediatrics
comparison: constant-rate infusion plus demanding dosing vs variable-rate feedback infusion plus demanding dosing

Conditions: Pain, Postoperative

Summary: in the case of the newlys developed pca, the infusion rate is increased according to the patient's need for bolus button, so that the pain can be controlled more efficiently.

in the case of the existing iv-pca, the analgesic drug was injected into the patient at a constant rate (ex. 1 ml / hr) and additional pain was controlled through the bolus dose (1 ml). as a result, the analgesic effect was insufficient, or the effect was excessive, causing side effects (nausea, vomiting, sedation, dizziness). especially in spinal surgery, the degree of pain sharply decreases from day 1 to day 2. classic iv-pca with constant infusion rate can not reflect this result. but in the case of the newlys developed pca, the infusion rate is increased according to the patient's need for bolus button, so that the pain can be controlled more efficiently. if the bolus button is not pressed for a certain period of time, it is expected that the injection rate will be reduced and the side effect caused by the analgesic agent will be decreased.

Eligibility criteria:
inclusion criteria: * spine fusion surgery at chung-ang university hospital with iv- pca under general anesthesia exclusion criteria: * unrecorded type of anesthetic agent * denial to the study * brain disorder * cardiopulmonary disease * psychiatric disorders
comparative study of immunogenicity and safety of flu-id vaccine versus flu-im vaccine

Conditions: Influenza

Summary: primary objective: \* immunogenicity to demonstrate that the influenza vaccine administered by intradermal route at least as immunogenic as the adjuvanted influenza vaccine administered by intramuscular route at the same dosage in term of ha antibody titres secondary objectives * immunogenicity * to describe the immune response 21 days after vaccination with the influenza vaccine administered by id route versus the adjuvanted influenza vaccine administered by im route.. * to describe the compliance of both vaccines administered with the european medicine agency (emea) note for guidance immunogenicity criteria, specific for elderly subjects * safety - to describe the safety profile after vaccination in each group * acceptability * to describe the pain at the injection site * to describe the comfort of the injection


Eligibility criteria:
inclusion criteria: * aged 65 years or older on the day of inclusion exclusion criteria: * febrile illness (oral temperature ≥37.5°c) on the day of inclusion * thrombocytopenia or bleeding disorder contraindicating intramuscular vaccination * unstable chronic illness * congenital or acquired immunodeficiency, * any blood or blood-derived product in the past 3 months * current abuse of alcohol or drug addiction * any vaccination in the past 4 weeks or planned in the 4 weeks following study vaccination * any vaccination against influenza in the past 6 months * subjects who previously received a vaccination against influenza by intradermal route
a prospective, observational, multicentre, 2 year study evaluating the use of eylea (aflibercept) for the treatment of neovascular (wet) age-related macular degeneration in uk nhs opthalmology clinics

Conditions: Wet Age-related Macular Degeneration

Summary: to assess the use of aflibercept over a 2 year period in vegf inhibitor naive and prior treated wet amd patients managed in 'real wold' clinic settings.


Eligibility criteria:
inclusion criteria: - age greater or equal to 50 years active choroidal neovascularisation secondary to amd in one or both eyes which in the opinion of the investigator will benefit from treatment with aflibercept subject willing and able to provide informed consent exclusion criteria: - patients must not have had any prior use of either bevacizumab or aflibercept other protocol-defined inclusion/exclusion criteria may apply

Keywords: wet age-related macular degeneration
representation of the body for patients with cancer

Conditions: Peritoneal Carcinomatosis

Summary: the project aims to understand better how patients live the event of cancer and live its consequences on their bodily representations. in the study, the dynamic of the body image is not restricted to appearance but include sensations and visions of the inner body, what explains the choice of peritoneal cancer, and the treatment by cytoreductive surgery and hipec. the three objectives of the study are: * identifying the impact of the representations of the treated body on the psychological strategies to cope with the disease, the bodily changes and the prospects of life; * making explicit the positive or negative impacts of these representations on the relationship between patients and health professionals (easing factors, misunderstandings, negotiations, etc.); * associating the health professionals with the study in its course and evaluation in order to elaborate a methodological collaborative approach between patients, health professionals and researchers in social sciences.


Eligibility criteria:
inclusion criteria: * patients eligible to treatment of cancer by cytoreductive surgery and hipec * primary (pseudomyxoma, mesothelioma) and secondary (colorectal, gastric, ovarian) peritoneal cancer * free consent * male or female * age \> 18 years * affiliate to social security exclusion criteria: * age \< 18 years, no french speaking * cerebrals metastasis * psychiatrics diseases