Kornimate/medical-research-clean huggingface dataset:
evaluation of safety and efficacy of glaucoma shunt (aurolab artificial drainage implant) in refractory glaucoma

Conditions: Glaucoma

Summary: the purpose of this study is to evaluate the efficacy and safety of aurolab artificial drainage implant (aadi) on intraocular pressure reduction in patients with refractory glaucoma.

aurolab artificial drainage implant is a non resistant tube device based on baerveldt implant. it reduces intra ocular pressure by draining aqueous from anterior chamber into sub-conjunctival space formed around base of the implant. reduction of intraocular pressure prevents further damage to optic nerve and functional visual field loss in advanced refractory glaucoma.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * significant optic nerve damage and visual field loss due to glaucoma in eligible eyes * eligible eyes is considered at high risk of failure/complication following conventional filtering surgery * eyes with uncontrolled glaucoma with prior history of filtering surgery/uveitic/ neovascular/developmental glaucomas * iop≥18 mm of hg with or without anti glaucoma medications * if taking glaucoma medications, stable dose for 6 weeks exclusion criteria: * age\<18 years * eyes with uncontrolled glaucoma expected to have favorable post-operative outcome by conventional trabeculectomy * corneal abnormalities that would preclude accurate iop readings * uncontrolled systemic diseases * endothelial cell count\<1800cells/mm * any other active ocular disease,(active uveitis, ocular infection)

Keywords: patient with refractory glaucoma
the impact of wechat group patient education on the eradication rate of helicobacter pylori

Conditions: Helicobacter Pylori Infection; Helicobacter Pylori Eradication; Patient Education

Summary: in this study, effects of oral and written education, wechat education plus oral and written education on helicobacter pylori eradication will be compared in a randomized way.

there are two randomized parallel groups in this study, control group and wechat group.all of the patients will be treated with amoxicillin + clarithromycin + bismuth + vonoprazan fumarate. in control group,the patients will be educated by oral and written way about the regimen. in wechat group, the patients will be educated by wechat oral and written way. then, the eradication rates, compliance, adverse events, patients' satisfaction and experience will be evaluated.

Eligibility criteria:
inclusion criteria: 1. aged between 18 and 75 years old; 2. h. pylori infection confirmed by any two positive outcomes of rapid urease test (rut), 13c-urea breath test (ubt) or histopathology. exclusion criteria: 1. previous therapy for h. pylori; 2. with significant underlying disease (e.g. decompensated liver cirrhosis, renal failure or malignant tumors) that may interfere the study; 3. history of gastric surgery, 4. pregnancy or lactation; 5. the use of ppi or antibiotics during the 4 weeks prior to enrolment; 6. previous history of allergic reactions to any of the medications used in this protocol; 7. unable to use smartphone and wechat 8. unwilling or incapable to provide informed consents.

Keywords: helicobacter pylori eradication patient education wechat group
screening for pancreatic exocrine insufficieny in metabolic associated fatty liver disease patients

Conditions: Pancreatic Exocrine Insufficiency

Summary: to investigate the frequency of pei in mafld

the growing epidemic of obesity is observed worldwide as lifestyles change to include higher caloric diets and decreasing physical activity. with obesity; ectopic fat deposition in certain organs is accompanied by insulin resistance, hypertension and dyslipidemia; which in turn leads to metabolic syndrome as such, metabolic associated fatty liver disease (mafld), the hepatic manifestation of metabolic syndrome, has already become the most common cause of liver disease worldwide with a prevalence 25% another important organ where ectopic fat deposition takes place is pancreas. although hepatic fat is mainly intracellular and fatty pancreas is a consequence of adipocyte infiltration, evidence exists that fatty pancreas could be used as the initial indicator of ectopic fat deposition recently, an advanced mri technique - mri-estimated proton density fat fraction (mri-pdff) - was shown to give reliable quantitative information of hepatic fat that is well correlated with liver biopsy the pancreas is composed of two glands - endocrine pancreas and exocrine pancreas- that are intimately mixed together into one organ although exocrine pancreas comprise more than 95% of the pancreatic mass, to date there is no study conducted about the exocrine pancreas function and pancreatic fat in mafld patients the fecal pancreatic elastase (pe) test is a valuable indirect assay used in the evaluation of pancreatic exocrine function pe testing has become a standard diagnostic tool exhibiting good correlation with the results of direct functional tests as well as morphological changes in the pancreas discovered via imaging techniques in the last decade, significant number of studies were conducted on pancreatic exocrine insufficiency (pei)

Eligibility criteria:
inclusion criteria: * age greater than 18 years, patients diagnosed as mafld exclusion criteria: * patients use steatogenic medications, hormone replacement therapy or herbal products, any alcohol intake. * patients with any history of pancreatic diseases like acute pancreatitis, chronic pancreatitis and pancreatic surgery. * patients with any malignancy.

Keywords: mafld
artificial intelligence based rapid identification of st-elevation myocardial infarction using electrocardiogram (arise)

Conditions: Myocardial Infarction, Acute

Summary: this is a randomized controlled trial (rct) to test a novel artificial intelligence (ai)-enabled electrocardiogram (ecg)-based supporting tool for improving the diagnosis and management of st-elevation myocardial infarction.


Eligibility criteria:
inclusion criteria: * patients in emergency department or inpatient department. * patients recieved at least 1 ecg examination. exclusion criteria: * the patients recieved ecg at the period of inactive ai-ecg system.
comparison of effectiveness of zinc supplementation with ors and bacillus clausii versus zinc with ors and saccharomyces boulardii in acute watery diarrhea in paediatric patients

Conditions: Acute Watery Diarrhea

Summary: the current study was carried out to directly compare the effectiveness of zinc supplementation with ors and bacillus clausii versus zinc with ors and saccharomyces boulardii among the local pediatric population presenting with acute watery diarrhea.

the results and importance of effective treatment for acute watery diarrhea in pediatric patients vary throughout the world. previously, very limited literature was available comparing the efficacy of bacillus clausii and saccharomyces boulardii in acute watery diarrhea, providing mixed results. the current study aims to directly compare the effectiveness of zinc supplementation with ors and bacillus clausii versus zinc with ors and saccharomyces boulardii.

Eligibility criteria:
inclusion criteria: * patients of either gender * aged 3 months to 5 years * with acute watery diarrhea last less fewer than 14 days * presenting with mild to moderate dehydration exclusion criteria: * patients with a history of blood or pus in their stools * history of recent antibiotic or probiotic treatment * patients with immunodeficiency conditions, acute systemic illnesses, or chronic diarrhea * patients with hypersensitivity to bacillus clausii or saccharomyces boulardii
the effect of mixture of natural products as salivary substitutes in treatment of xerostomia

Conditions: Sjogren's Syndrome; Xerostomia

Summary: evaluate the efficacy of natural herbal mixture of aloe vera gel, coconut oil and peppermint in comparison to the carboxy methyl cellulose on xerostomia in a sample of patients with sjogren's syndrome.

the study will be held in the rheumatology clinic at el kasr al-ainy cairo university hospital in patients with sjogren's syndrome. population: a random sample of adult patients diagnosed with primary or secondary sjogren's syndrome attending at the rheumatology clinic in el kasr al-ainy, cairo university hospital will be enrolled in the study in a consecutive order. the interventions will be in the form of gel to be maintained for long period in the oral cavity. the intervention is a moisturizing gel containing 10% aloe vera jelly, 10% coconut oil, 3% peppermint essential oil, 3% carboxy methyl cellulose, 10% propylene glycol, and 0.1% potassium sorbate and water up to 100%. the control is also a moisturizing gel contained 3%carboxy methyl cellulose, 3% peppermint essential oil, 10% propylene glycol, 0.1% potassium sorbate, and water up to 100%. both gels had similar appearance, color, smell, and weight. they will be produced by professional pharmacist in faculty of pharmacy, al azher university, cairo, egypt.it was taken from previous study with modification in percentage of aloe vera and adding coconut oil. both gels will be applied topically in all surfaces of oral mucosa 4 times daily after eating and before sleep . the same individuals will deliver the trial interventions in all study groups, both gels will be used for 2 weeks then washout period for 7 days then cross over them. modification of life style will be promoted as daily tooth brushing, hydration with sufficient amounts of water, eating fibrous food as fruits and vegetables, avoid any alcohol mouth wash or any other topical oral products. the medication will be withdrawn if any allergic reaction occurs.

Eligibility criteria:
inclusion criteria: 1. adult patients 2. patients physically able to participate in the clinical trial. 3. patients diagnosed with sjogren's syndrome using 2016 acr/eular classification criteria (shiboski et al., 2017). 4. secondary sjogren patients with rheumatoid arthritis. 5. patients with clinical oral dryness positive scores. exclusion criteria: 1. patients with previous radiotherapy. 2. patients not approved to participate in the clinical trial. 3. patients didn't complain from xerostomia. 4. patients with diabetes mellitus. 5. patients taking drugs caused xerostomia as antidepressants, anticholinergics, antihistamines, and anxiolytics and antihypertensives (campos et al., 2019). 6. patients with symptomatic oral lesions

Keywords: xerostomia oral dryness dry mouth
outcomes after perforator flap reconstruction for breast reconstruction and/or lymphedema treatment

Conditions: Breast Cancer; Hereditary Breast/Ovarian Cancer (brca1, brca2); Acquired Lymphedema; Congenital Lymphedema

Summary: the goal of this prospective, observational study is to investigate the clinical, psychosocial, and patient satisfaction outcomes of patients who undergo perforator flap reconstruction for breast reconstruction and/or vascularized lymph node transfer (vlntx) for the treatment of lymphedema. the investigators hypothesize that (1) perforator flap breast reconstruction will result in excellent clinical, psychosocial, and patient satisfaction outcomes compared to non-perforator flap breast reconstruction; (2) perforator flap breast reconstruction is associated with less persistent postsurgical pain than other forms of breast reconstruction, even after controlling for major cofactors, such as the extent of auxiliary lymph node dissection and the use of radiation therapy; (3) perforator flap reconstruction for the treatment of lymphedema (i.e., vlntx ) will result in the reduction of symptoms and complications of lymphedema.

breast cancer is a serious health issue that affects 1 in 8 women. although numerous treatments have arisen in recent years to aggressively combat this disease and increase survivorship, many survivors develop a crippling condition that can result in devastating physical and psychological impairments. breast reconstruction by any method may help recovery psychologically. however, some individuals still report experiencing pain following their recovery from surgery. additionally, secondary lymphedema is a common yet poorly understood complication of breast cancer patients. for those individuals who undergo axillary lymph node dissection the rates of incidence of lymphedema approach 47%. these rates tend to increase further for patients who receive irradiation treatment or mastectomies. currently there is no known cure for lymphedema. current treatments include non-invasive measures as well as surgical interventions. vascularized lymph node transfer (vlntx) is a fairly recent surgical procedure that has shown promising results. the goal of this research study is to analyze the clinical outcome of subjects who undergo breast reconstruction with perforator flaps and/or vlntx using information collected as part of standard care. clinical data will be collected prospectively. all subjects who undergo a surgical procedure will complete the online persistent postsurgical pain assessment questionnaire. the breastq questionnaire will be completed by patients prior to and after undergoing breast reconstruction and/or lymphedema treatment.

Eligibility criteria:
inclusion criteria: * undergoing perforator flap surgery for breast reconstruction and/or vascularized lymph node transfer for treatment of lymphedema exclusion criteria: * pregnant * unable to read

Keywords: breast cancer braca1/2 genotype acquired lymphedema congenital lymphedema
creating vip corps to reduce maternal deaths

Conditions: Maternal Morbidity and Mortality

Summary: the goal of this observational study is to create and rigorously evaluate a violence intervention and prevention corps (vip corps) training using a randomized controlled trial among undergraduate and professional students; and to develop a novel maternal injury surveillance system (miss) to complement an existing maternal violent death registry in kentucky.

the participant population defined in this study are undergraduate and professional students within their last educational year in a helping professionals program at the university of kentucky, ages 18-30. this study will permit the creation of effective programming to train the next generation of health and social service professionals prepared to help reduce kentucky's maternal mortality and injury rates over time with implementation. aim 1: 1. create and rigorously evaluating violence intervention and prevention corps (vip corps) training using a randomized controlled trial among undergraduate and professional students. 2. develop a novel maternal injury surveillance system (miss) as a complement to an existing maternal violent deaths registry to accurately and reliably enumerate maternal injuries and deaths due to violence. aim 2: 1. determine the effectiveness of complementary intervention and prevention strategies to increase interpersonal violence, substance use/disorder (ipv, su/d), depression or anxiety screening. 2. reduce symptoms among those who screen positive, and ultimately reduce maternal injuries and deaths due to violence. 3. prospectively evaluate the effectiveness of a novel vip training as the intervention condition relative to an attention control (su/d and ipv awareness), to increase knowledge of the effects of intimate partner violence (ipv) on health outcomes, report intimate partner violence (ipv) screening behaviors, intimate partner violence (ipv) detection, and to reduce intimate partner violence (ipv) frequency among patients and clients over time.

Eligibility criteria:
inclusion criteria: * students enrolled in a helping professions program * 18 years of age through 30 years of age * students whom will have direct interaction with patients or clients that may experience interpersonal violence (ipv) exclusion criteria: * students not enrolled in a helping professions program * students under age 18 or over age 30 * students with no direct interaction with patients or clients

Keywords: maternal morbidity maternal mortality vip corps pregnancy-associated injuries pregnancy-associated deaths
validity of neurocognitive assessment methods in childhood adhd

Conditions: Neurodevelopmental Disorders; Attention Deficit Hyperactivity Disorder

Summary: the aim of the study is to examine the prospective validity of neurocognitive functions and emotional factors in schoolchildren with adhd and a control group of typically developing schoolchildren at baseline and after three years.

in spite of extensive research on children with adhd, there is still insufficient understanding of the discriminative validity of neurocognitive tests and how test results of neurocognitive functions and ratings of emotional factors and adhd symptoms change over time and interacts during development. the project is studying the validity of clinical assessment methods within the swedish child and adolescent psychiatry service (cap) related to the identification of adhd, additional impairments, and comorbidity. the prospective validity of neurocognitive functions and emotional factors in schoolchildren with adhd and a control group of typically developing schoolchildren at baseline and after three years will be investigated. specific aims: aim i: study how attentiveness and impulsivity in adhd change over three years by comparing the results of psychological tests and rating scales at baseline and after three years aim ii: study intellectual development in adhd by comparing the results of intelligence tests at baseline and after three years- aim iii: study how emotional factors change over three years by comparing the results of rating scales at baseline and after three years

Eligibility criteria:
inclusion criteria: the adhd-group: • the individuals were assessed and diagnosed with adhd at the neuropsychiatric unit of the cap clinic in lund in 2011-2012 non-clinical group: * school children from lund. exclusion criteria: * if the individual had a diagnosed intellectual disability * if the individual required an interpreter to participate in the study

Keywords: intelligence anxiety attention conduct behavior follow-up children
a comparison of two doses of intranasal dexmedetomidine for premedication in children

Conditions: Anxiety, Separation

Summary: the purpose of the study is to determine if 4mcg/kg of intranasal dexmedetomidine is better than 2mcg/kg in successfully sedating a child prior to induction of anesthesia.

dexmedetomidine is a selective alpha-2 adrenoreceptor agonist that has sedative, anxiolytic and analgesic properties without causing respiratory depression. it has been administered safely and effectively via a number of routes including as an intravenous infusion, intramuscularly, intranasally, buccally and orally . yuen et al established that the median time of onset of sedation is 25-30 minutes, making it an ideal agent for preoperative sedation. the same group also studied doses of 1 mcg/kg and 2 mcg/kg as a sedative premedication and found that the success rates of appropriate sedation at induction in children aged 1 to 8 years were 53% and 66% respectively, with a dose related increase in successful sedation. much higher doses of dexmedetomidine have also been used safely. administered intravenously, 3mcg/kg of dexmedetomidine has been shown to provide satisfactory sedation for paediatric mri in 97% of cases, without adverse effects. the investigators aim to show that high dose intranasal dexmedetomidine is a safe, effective and an easily administered sedative premedication. the investigators hypothesise that 4mcg/kg compared to 2mcg/kg of intranasal dexmedetomidine will lead to at least a 20% increase in the proportion of satisfactorily sedated patients at the time of anaesthesia induction. the primary outcome will be the proportion of children with satisfactory sedation at the time of anaesthesia induction. suitable patients will be identified from the theatre lists and consent will be sought from their legal guardians during preassessment clinic or during their anaesthetic preoperative assessment on the ward. in a previous study, 66% of children aged 1-5 years were satisfactorily sedated at the time of induction with 2 mcg/kg of intranasal dexmedetomidine. in order to find a 20% difference with 4 mcg/kg of dexmedetomidine, the investigators' sample size needs to be 140 (70 in each group), for a power of 0.8 and a 5% false positive rate. the demographic data will be analysed by t test and chi-square test. the proportions of satisfactory sedation will be analysed by chi-square test. the onset sedation time and duration of sedation will be analysed by survival analysis. the vital signs over times will be expressed by percentage changes from baseline and estimated by mean and standard errors. a p-value\<0.05 will be considered statistically significant.

Eligibility criteria:
inclusion criteria: * all children of american society of anesthesiologists (asa) physical status classification i or ii (healthy) between the ages of 6 months and 5 years undergoing surgery at queen mary hospital exclusion criteria: * any patient receiving other sedative premedication, allergy to dexmedetomidine, organ dysfunction, cardiac arrhythmia and congenital heart disease.

Keywords: sedation dexmedetomidine pediatric preoperative period
a study of the efficacy and safety of topiramate in the prevention of migraine

Conditions: Migraine; Common Migraine; Classic Migraine; Headache

Summary: the purpose of this study is to evaluate the safety and efficacy of three doses of topiramate (50 milligrams\[mg\], 100mg, and 200mg taken daily) compared with placebo in the prevention of migraine.

this is a randomized, double-blind, placebo-controlled, parallel-group, multi-center study to evaluate the effectiveness and safety of three different doses of topiramate (50mg, 100mg, and 200mg daily) in migraine prophylaxis. the study consists of five phases: baseline (determination of whether patients meet the eligibility criteria and tapering of any migraine medication patients are already taking); initial titration and double-blind phase (8 weeks) which begins with 25 mg/daily increasing to the assigned (50, 100, 200 mg/day topiramate); followed by a maintenance period at the target dose (18 weeks); tapering transition phase (up to 7 weeks); and open-label extension up to 6 months (to a maximum topiramate dose of 1600 mg/day); doses are adjusted to maximize effectiveness and minimize side effects. the primary study hypothesis is that one or more of the three doses of topiramate (50, 100, 200 mg/day) will be superior to placebo in the prophylaxis of migraine based on the change in monthly (28 day) migraine period rate from the prospective baseline period to the double-blind phase and that topiramate treatment is well tolerated. during the titration period (8 weeks), doses are increased to target dose of daily topiramate (50 milligrams\[mg\], 100, or 200mg) or placebo, taken twice daily by mouth. doses are continued for 18 weeks, adjusted over 7 weeks, and continued for up to 6 months during the open-label extension.

Eligibility criteria:
inclusion criteria: * medical history consistent with migraine with or without aura according to the international headache society (ihs) for at least 6 months prior to the study * between 3 to 12 migraine periods and no greater than 15 headache days (migraine and non-migraine) per month during the baseline phase * no clinically significant abnormalities on neurological exams, electrocardiogram (ecg) or clinical laboratory test results at baseline * female patients must be postmenopausal for at least 1 year, surgically incapable of childbearing, practicing abstinence, or practicing an acceptable method of contraception (requires negative pregnancy test) exclusion criteria: * patients with headaches other than migraine * patients with episodic tension or sinus headaches * onset of migraine after age of 50 years * patients who have failed more than two adequate regimens for migraine prophylaxis * patients who overuse pain medications or certain other medications

Keywords: migraine common migraine classic migraine headache topiramate prophylaxis