Kornimate/medical-research-clean huggingface dataset:
shoulder disorders in patients with parkinson's disease

Conditions: Parkinson's Disease; Shoulder Pain

Summary: parkinson's disease (pd) is a multisystem neurodegenerative disorder that is increasingly recognized in our ageing population. it is characterized by cardinal clinical features including bradykinesia, tremor, rigidity, and postural instability. for most people with pd, the most serious concern is with the motor system: stiffness, slowness of movement, impaired handwriting and coordination, poor mobility and balance. however, more than half of all people with pd have experienced painful symptoms. most people experience aching, stiffness, numbness and tingling at some point in the course of the illness. defazio et al reported that pain may begin at clinical onset of pd or thereafter as a non-motor feature of pd.5 aching muscles and joints are especially common in pd. rigidity, lack of spontaneous movement, abnormalities of posture and awkward mechanical stresses all contribute to musculoskeletal pain in pd.

one of the most common musculoskeletal complaints is shoulder pain or shoulder disorders, including frozen shoulder, bursitis, and rotator cuff lesions. actually, shoulder pain or shoulder disorder can be the first sign of pd. the prevalence and severity of shoulder disorders in parkinson's disease are not totally clear. in a retrospective study, stamey found shoulder pain was present in 11% of patients with pd. over the past ten years ultrasound (us) has become popular in the evaluation of shoulder disorders. it allows for the detailed assessment of a wide range of changes involving different anatomic structures of the shoulder joint, including rotator cuffs, biceps tendon, and subdeltoid bursa. koh et al found among 33 pd patients, 22 patients had abnormal us findings on the dominant side, and all 22 patients with abnormal us finding had a tendon tear and 9 patients had frozen shoulder. however, there were no control group in koh' s study, and diagnosis of frozen shoulder with us findings is still controversial. the purposes of this study are to evaluate patients with pd with a combination of physical examination and us study of the shoulder, and to compare the frequency and type of shoulder lesion in us between patients with pd and normal subjects. the investigators also plan to test the correlation between shoulder disorders or us abnormality and the severity of pd.

Eligibility criteria:
inclusion criteria: * patients fulfilled the diagnosis of pd, as described by the united kingdom parkinson's disease society brain bank, * aged 50 to 80 years old. exclusion criteria: * fracture or dislocation of the shoulder, * previous shoulder joint surgery, * severe medical comorbidities, * cognitive impairment (mini-mental status examination \< 24).
impact of proximal colon retroflexion in colorectal cancer screening programme

Conditions: Colorectal Neoplasms; Adenoma Detection Rate

Summary: colorectal cancer (crc) is the most common tumor and the second leading cause of death in the western world. the decrease in incidence and mortality by crc in the population undergoing screening has been observed. colonoscopy is the recommended method for detecting tumors in early stages, as well as identifying and resecting adenomatous polyps, which are the precursor lesions of most crcs. colonoscopy should be of high quality to decrease incidence and mortality by crc and avoid interval cancer. the literature shows that colonoscopy does not prevent right colon lesions in the same way as the left colon lesions, with most of the interval cancers located in the right colon. studies published so far show an increase in the adenomas detection rate (adt) in the right colon in the second visualization of this segment and an increase between 2 and 10% if this second examination is performed with the proximal retroflexion maneuver.retroflexion is a safe maneuver in expert endoscopists. the aim of our study is to evaluate the adt in the right colon by means of a second visualization by performing proximal retroflexion or second frontal visualization at random in the ccr screening population.


Eligibility criteria:
inclusion criteria: * subjects participating in the colorectal cancer screening program with faecal immunological test \> 100ng / ml. * ages between 50-69 years. * adequate preparation according to the boston scale: in right colon (score\> 2 in this section) * informed consent. exclusion criteria: * refusal to give informed consent. * subjects with elevated colorectal cancer risk due to family history or inherited diseases of polyposis or inflammatory bowel disease * symptomatic subjects. * diverticulitis, inflammatory bowel disease or colonic stenosis during the exploration * inadequate preparation according to boston cleanliness scale (score ≤ 2 in right colon)

Keywords: retroflexion proximal colorectal cancer screening programme adenoma detection rate right colon
clinical and histological evaluation of hesperidin as a direct pulp capping material

Conditions: Pulp Exposure, Dental; Dental Pulp Capping

Summary: direct pulp capping technique is one of the oldest known treatments for exposed pulp tissue, and there is a continuous requirement for the most efficient materials to be used in this approach. successful pulp capping is the usual way to preserve the vitality of tooth and avoid root canal treatment or surgical tooth extraction.


Eligibility criteria:
inclusion criteria: * good oral hygiene, * sound wisdom teeth with closed apices with normal pulp vitality response * no periodontal disease or periapical lesions on periapical radiograph * cooperative patients approving to participate in the study exclusion criteria: * medically compromised participants * evidence of parafunctional habits * heavy smokers * teeth with signs and symptoms of irreversible pulpitis or pulp necrosis * severe periodontal problems or pathological periapical changes * teeth with open apex or pulp calcification
ussing experiments to evaluate the role of medication-induced microscopic colitis

Conditions: Microscopic Colitis

Summary: medication use, especially nsaids and ppis, prior to diagnosis is considered a risk factor for mc development. however, the exact pathophysiological mechanism is unclear. it is hypothesized that nsaids, ppis, and ssris may have an effect on the colon permeability, due to an idiosyncratic reaction which results in a local immune response. mc patients are considered to be susceptible hosts, prone to react on administration of abovementioned drugs. in order to test this hypothesis and to generate new insights in the pathophysiology of mc, we want to perform an ussing chamber experiment using fresh colon tissue samples. the primary objective is to assess ex vivo the effect of nsaids and ppis on epithelial permeability of colon biopsy specimens of mc and non-mc patients, using the ussing chamber system


Eligibility criteria:
inclusion criteria: * the indication for colonoscopy is a relapse of mc (active) / mc in remission (remission) / no mc (control) * patient is not treated with nsaids / ppi / ssri in week before inclusion exclusion criteria: * age below 18 years at the time of diagnosis * use of anticoagulants or immunosuppressive drugs * severe co-morbidities hindering an endoscopic procedure * a previous history of any type of chronic colitis, ibs, ibd, colon carcinoma or (partial) colectomy * a recent (last year) diagnosis of infectious diarrhea or radiation proctitis. * use of medication known to influence intestinal permeability * excessive alcohol usage (\>20 standard units per week) * not capable of signing an informed consent
search for prognostic factors associated with better survival in refractory cardiac arrest

Conditions: Cardiac Arrest (CA); ExtraCorporeal Life Support (ECLS)

Summary: through this retrospective observational study (over 4 years; period analysed: 1st january 2011 to 31st december 2014), we looked for prognostic factors associated with better survival in refractory cardiac arrest by: * assessing the overall survival rate * evaluating the frequency of intra et extra-hospital events and by comparing these with the survival rate * studying no flow, low flow, rhythm at initial management, troponinemia, lactatemia and blood ph in the different groups.


Eligibility criteria:
inclusion criteria: * patients with in-hospital or out-of-hospital refractory ca who underwent ecls exclusion criteria: * ca occurring during cardiac surgery * age \> 75 years or \< 18 years
encore moms:engaging communities to reduce morbidity from maternal sepsis

Conditions: Maternal Sepsis; Infections

Summary: sepsis is the second leading cause of maternal death in the u.s. for racial and ethnic minoritized birthing people, especially those who are black, living in poverty, and from underserved communities, labor and postpartum are particularly vulnerable risk periods. the goal of this multi-center, multidisciplinary observational study is to optimize risk prediction accounting for the social determinants of health, and establish a novel maternal care continuity model to reduce sepsis- related death and disability and increase maternal health equity.

maternal sepsis is the second leading cause of maternal death, major cause of morbidity, and preventable in most cases. encore moms: engaging communities to reduce morbidity from maternal sepsis will (aim 2) develop algorithms to optimize prediction of sepsis around delivery and postpartum. in the ug3 phase, robust community engagement and research infrastructures were established to: aim 2a. create a rich electronic health records (ehr) database from the perinatal research consortium (prc). aim 2b. collate neighborhood-level datasets characterizing social determinants of health (sdoh) in the uh3 phase, the investigators will aim 2c. harmonize patient-level ehr and neighborhood-level sdoh datasets and use machine learning models to analyze the individual and joint contributions of patient and neighborhood factors to optimize sepsis risk prediction within the prc sample.

Eligibility criteria:
inclusion criteria: * be 18 years or older * delivery admission (and) postpartum readmission at one of the perinatal research consortium sites 2014-2021 exclusion criteria: * under 18 years old * delivery admission (and) postpartum readmission at hospital that is not in the perinatal research consortium * delivery admission before 2014 or after 2021

Keywords: electronic health record post partum period pregnancy maternal health
supraglottic airway devices in pediatric difficult airway situations

Conditions: Airway Morbidity; Emergencies

Summary: the purpose of the study is to compare three supraglottic airway devices (combitube, easytube, laryngeal mask airway) to endotracheal intubation in a simulated difficult airway scenario in a pediatric manikin.

supraglottic airway devices (sad) have been designed for the "cannot intubate, cannot ventilate" scenario in prehospital as well as intrahospital settings and are utilized in medical emergency services and emergency departments all over the world, not only for anticipated and unanticipated difficult airway situations but also as an airway device used by non-anesthesiologists or in situations where only limited practice is possible. securing an airway in a pediatric emergency situation is crucial. unfortunately, pediatricians usually lack the required skills and regular practice to perform endotracheal intubation (eti, which is the gold standard for securing an airway) quickly and safely. sads would pose a safe and feasible alternative to eti. however, no studies on this topic are available. the investigators therefore wanted to evaluate three different sads (combitube, easytube, laryngeal mask airway) in simulated difficult airway situations in a pediatric manikin in comparison to eti.

Eligibility criteria:
inclusion criteria: * pediatricians * residents * interns * written informed consent form exclusion criteria: * none
effect of consuming a combination of probiotic strains and a combination of plant extracts and a probiotic strain on the production and nutritional composition of breast milk

Conditions: Breast Milk Expression

Summary: the objective of this trial is to evaluate the effect of the consumption of a combination of probiotic strains (prob-milk) and of a combination of plant extracts plus an inactivated probiotic strain (voluntasprob) on the production volume and the nutritional composition and the microbiota. of breast milk in lactating women.

previous studies have shown the galactogogue effect of fenugreek, fennel, and milk thistle. however, to date no study has considered the evaluation of all three extracts. additionally, certain probiotic strains of lactobacillus and bifidobacterium also appear to increase milk production in animal studies. the objective of this trial is to evaluate the effect of the consumption of a combination of probiotic strains (prob-milk) and of a combination of plant extracts plus an inactivated probiotic strain (voluntasprob) on the production volume and the nutritional composition and the microbiota. of breast milk in lactating women. this is a preliminary study whose purpose is to gather information for future studies.

Eligibility criteria:
inclusion criteria: 1. lactating women between 18 and 45 years old, who have given birth to a healthy baby at term (born between 37 and 42 weeks). 2. who have the perception of having little volume of milk or a nutritional composition of milk that is not adequate for their baby 3. that they are between week 2 and week 6 of breastfeeding, and that at the time of beginning the study they are not supplementing with formula milk the feeding of their baby. 4. that they have the firm intention of breastfeeding for 28 more days. 5. women who agree to participate and have read, understood and signed the informed consent exclusion criteria: 1. suffering from any disease that may hinder or prevent breastfeeding 2. being currently consuming or having consumed in the two weeks prior to the study a probiotic or a supplement with plant extracts. 3. being consuming any drug that can alter the volume or composition of breast milk. 4. have an allergy to any antibiotics or peanuts 5. have an allergy to any of the components of the products under study

Keywords: breastfeeding galactogogue plant extracts probiotics
clinical effect of acupuncture in neurodegenerative diseases on traumatic brain injury patients

Conditions: Neurodegenerative Diseases

Summary: traumatic brain injury (tbi) is an altered brain function caused by an external force, which may annually have 69 million incidence cases all over the world. increasing evidence suggests that tbi may be a major risk of beta amyloid (aβ)-associated neurodegenerative disorders, such as alzheimer's disease, frontotemporal dementia, and parkinson's disease. investigations from brain imaging studies revealed that aβ density maps of tbi patients overlapped with those with alzheimer's disease, and increased aβ density not only associated with prolonged tbi duration but also associated with decreased white matter integrity. it has been suggested that the axonal injury and cerebrovascular dysfunction due to tbi may associate with the elevated level of aβ peptides. the increasing accumulation in aβ due to tbi may contribute to the initiation of the pathological alterations in neurodegeneration diseases. recent animal studies suggest that acupuncture may promote regeneration of nerves in injured tissues and reduce the concentration of aβ in brain. moreover, recent clinical trials also indicate that acupuncture may improve the vascular cognitive impairment due to cerebral small vessel disease. thus, acupuncture treatment on tbi may not only be of benefit for the tbi recovery but also act to interrupt the pathological changes in these neurodegenerative diseases.


Eligibility criteria:
inclusion criteria: 1. age ≥ 20 years old 2. gcs score \> 8 3. loss of consciousness \< 24 hr 4. the physical condition is suitable for acupuncture treatment 5. having adequate competency for understanding the study and a willingness to sign the written informed consent forms 6. be able to commence the acupuncture intervention within 2 weeks after tbi diagnosis exclusion criteria: 1. medical history of neurological, cardiovascular events, e.g., epilepsy, stroke, major depression or anxiety 2. a history of the mental disorder, e.g., major depression or anxiety 3. other major medical conditions, e.g., active cancer, uncontrolled diabetes, amputation 4. receipt of acupuncture within the 6 months prior to study entry 5. patients with pacemaker or metal graf

Keywords: acupuncture traumatic brain injury
the effect of non invasive brain stimulation on impulsivity in borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: a pilot study to examine the effects of non-invasive brain stimulation on impulsive behaviour in patients diagnosed with borderline personality disorder. patients who received the neurostimulation sessions will be enrolled in short term psychotherapy (3-month)


Eligibility criteria:
inclusion criteria * clinical diagnosis of borderline personality disorder (dsm-v) * resident of great montreal * ability to make decision * clinical score is equal or more than 17 in borderline personality disorder severity index (bpdsi) resident of greater montreal area, exclusion criteria: * material metal in the brain * history of seizure or epilepsy * severe scalp irritation or eczema * recent scares, cut wounds, tattoo on the scalp * severe substance use disorder * clinical diagnosis of severe mood disorders o * active psychotic episode * pregnancy

Keywords: impulsivity non-invasive brain stimulation psychotherapy
the impact of the anaesthetic technique employed on the quality of recovery in patients undergoing hysterectomy surgery.

Conditions: Anesthesia; Analgesia; Acute Pain

Summary: the objective of this study is to evaluate the results of different anesthesia methods (general anesthesia with epidural catheter application and spinal anesthesia with epidural catheter application) applied in elective hysterectomy surgeries performed in our hospital. the aim is to compare the advantages of both methods.

the study was designed as a prospective observational study. the researchers participating in the study were not involved in administering any medications to the patients. a review of the patient records will result in the creation of two differentiated groups according to the anesthesia method administered: group 1 will include patients who underwent general anesthesia with an epidural catheter, while group 2 will include patients who underwent spinal anesthesia with an epidural catheter. the quality of recovery score will be evaluated using a 15-question scale both preoperatively and postoperatively. the researchers will evaluate quality of recovery using the 15-item quality of recovery scale (qor-15).

Eligibility criteria:
inclusion criteria: * patients scheduled for elective hysterectomy * patients with the american society of anaesthesiologists (asa) physical status class1-2-3 * those who are literate enough to answer the compilation quality of recovery score (qor-15) questionnaire exclusion criteria: * patients with contraindications for neuraxial anesthesia * patients with the american society of anaesthesiologists (asa) physical status score above 3 * the presence of another malignant neoplasm, other than the indication for hysterectomy, * patients with substance abuse disorders, including alcohol and drug addiction * patients who do not consent to or desire to be included in the study.

Keywords: quality of recovery-15 opioid consumption acute pain scores
to evaluate if wide blood sugar fluctuations lead to injury of heart function and heart nerves

Conditions: Type 1 Diabetes Mellitus

Summary: this proposal will test if, in patients with type 1 diabetes, wide blood glucose fluctuations lead to the injury to heart nerves , called cardiac autonomic neuropathy (can), and to impaired heart contractile (pumping) function and heart failure. it will also evaluate the natural history of heart failure and enhanced cardiac risk in patients with type 1 diabetes in the current standard of diabetes care.


Eligibility criteria:
inclusion/exclusion criteria: * male or female between the ages 18-65, with type 1 diabetes of 5-10 years duration who are free of complications and age-and-sex-matched healthy control volunteers. * hemoglobin a1c greater than 7 %. (for type 1 diabetics) * if you are a woman of childbearing potential you must agree to use an acceptable birth control method throughout the duration of the study. the methods of birth control that you can use are: oral contraceptives (birth control pill), iud or a barrier method (e.g. diaphragm or condom with spermicide). * you should have no history of any cardiovascular disease including any form of coronary artery disease, congestive heart failure, known arrhythmias (irregular heart beats), valvular disease or high blood pressure. * if you have any pacemaker or icd, if you have any metallic foreign body such as surgical implants or clips or foreign bodies in the eye or orbits, wearing medication patches containing foil, or any other metal in the body or if you are claustrophobic you cannot participate in this study. * you should be free of any diabetic complications (e.g. nephropathy or kidney damage, retinopathy or eye damage), have no history of previous kidney, pancreas or cardiac transplantation, any other severe chronic illness that has neuropathy (numbness, burning or tingling) and/or neurologic disease as a recognized complication (e.g. parkinson's disease, epilepsy), or any other serious medical conditions that may shorten life span (e.g. disabling stroke, chronic obstructive pulmonary disease). * you should be free of any malignancy other than basal cell skin cancer. * no history of alcohol abuse. * you should not use any agents or drugs that interfere with the imaging techniques described below. * you must be able to cooperate with the test protocols that are described below and be willing to sign this consent form. inclusion for control group: * bmi \<30 * if female, must not be pregnant or nursing * normal blood pressure * normal labs-(glucose and lipids)
efficacy of torque teno virus as a biomarker for predicting treatment response of immune checkpoint inhibitor therapy and postoperative outcome in nsclc patients

Conditions: NSCLC (Non-small Cell Lung Cancer)

Summary: first discovered in 1997 the torque teno virus (ttv) can be found in the vast majority of the human population throughout their lifetime. the ttv levels correlate with infectious diseases and organ rejection and are therefore currently being investigated as a tool to optimize the management of patients after solid organ transplantation (sot). while ttv levels are already tested to guide immunosuppressive therapy its significance for oncologic patients is unclear. in recent years immune checkpoint inhibitors (icis) are increasingly implemented in multimodal therapy approaches for patients with non-small-cell lung cancer (nsclc). since ici and ttv levels depend on t-cell function, the ttv load may be a relevant biomarker for the treatment response as well as complication risk after ici therapy. current standard imaging using percist and recist criteria is prone to misinterpretation of treatment response of ici therapy due to pseudoprogression and nodal immune flaring. this study aims to prospectively analyze ttv levels in nsclc patients before, during and after neoadjuvant chemo-immunotherapy and correlate inter- and intraindividual changes in ttv levels with response rates observed on pet/ct restaging and histopathological response rates as well as postoperative outcome.


Eligibility criteria:
inclusion criteria: - histologically or cytologically verified nsclc stage ii-iv (omd) according to uicc tnm8 edition considered operable in curative intent after neoadjuvant systemic therapy containing immune checkpoint inhibition by local multidisciplinary tumor board (mdt) decision. ecog \< or = 1 staging with pet/ct and cmri/cct written informed consent exclusion criteria: -