Kornimate/medical-research-clean huggingface dataset:
bladder epicheck european haematuria study

Conditions: Hematuria; Cystoscopy; Urothelial Carcinoma Bladder; Urothelial Carcinoma of the Renal Pelvis and Ureter; Urothelial Carcinoma of the Urinary Bladder

Summary: the goal of this observational study is to further validate the sensitivity and specificity of bladder epicheck in primary detection of urothelial carcinoma in participants aged 45 years or older presenting with haematuria, compared to cystoscopy and pathology, if performed. participants will provide a voided urine sample, and data from standard of care haematuria work-up will be collected.


Eligibility criteria:
inclusion criteria: 1. participants aged 45 years or older 2. participants who are willing and able to provide written informed consent and adhere to study procedures 3. participants presenting with visible and/or non-visible haematuria within 6 months prior to study enrollment 4. participants scheduled to undergo standard of care cystoscopy for urinary bladder examination within 60 days after study enrollment 5. participants who are able to produce at least 10 ml of voided urine exclusion criteria: 1. participants with history of urothelial cancer in the bladder and/or upper urinary tract 2. participants who had prior cystoscopy for haematuria within the past 2 years 3. participants previously enrolled in this study 4. participants treated for prostate cancer within the last 12 months 5. participants treated for kidney cancer within the last 12 months 6. participants with untreated urinary tract infection 7. participants with symptomatic urinary tract stones (e.g. flank pain) 8. participants on dialysis for end stage renal failure 9. participants with a long term urinary catheter 10. pregnancy (self-reported) 11. participants who, because of medical status, or frailty is not expected to be able to complete the full diagnostic pathway

Keywords: urine test methylation primary detection
compare conventional colonosocpy to endoscopic afi, nbi for dysplasia detection for ulcerative colitis & cholangitis

Conditions: Colitis, Ulcerative; Cholangitis, Sclerosing

Summary: this study is being done to: to attempt to increase the detection of precancerous colon tissue in patients with chronic ulcerative colitis and primary sclerosing cholangitis; to determine if an investigational scope that can look at the lining of the colon in different ways will help the doctor identify abnormal tissue in patients with chronic ulcerative colitis and concurrent primary sclerosing cholangitis; and to determine if this investigational scope can accurately detect precancerous or cancerous tissue in patients with chronic ulcerative colitis that are known to have had cancerous or precancerous tissue in the past.

patients with concurrent chronic ulcerative colitis and primary sclerosing cholangitis or patients with chronic ulcerative colitis and known colorectal dysplasia or cancer, presenting for surveillance colonoscopy will be recruited. after giving informed consent patients will then undergo colonoscopy in a segmental fashion. colonoscopy with white light will be performed to the cecum and examination will be performed on withdrawal. first conventional white light will be used to examine the cecum and ascending colon and random biopsies will be obtained. all endoscopically apparent lesions will be biopsied separately. immediately following will be examination of that segment of cecum and ascending colon under afi first, then nbi with targeted biopsies of suspicious areas being taken. the afi and nbi modality will be achieved by simply flipping a switch.. if necessary, washing of oozing blood from random biopsy sites will be performed., the remainder of the colon will be assessed in like fashion: transverse, descending and rectosigmoid. because high definition endoscopy is the default modality, this will be in use throughout the procedure. all lesions detected will be documented and biopsied for a maximum of four biopsies per suspicious lesion. note will be taken of which modality resulted in visualization of the lesion. data on the factors under study will be collected: i) disease type (cuc + psc or cuc with known dysplasia), ii) age, iii) sex, iv) length of time with disease, v) extent of disease, vi) the interaction between iv and v will be collected. in addition, dysplasia yes/no will be established after biopsy histology is established and the modality under which abnormalities were observed will also be recorded.

Eligibility criteria:
inclusion criteria: * patients requiring a clinically indicated surveillance colonoscopy * able to give informed written consent * history of chronic ulcerative colitis and colonic dysplasia/or cancer or primary sclerosing cholangitis exclusion criteria: * patients with known colonic obstruction * inr ./= 2.5 or thrombocytopenia ,50,000 * patients with clinically important cardiopulmonary disease who are unable to safely undergo prolonged conscious sedation * pregnancy * symptomatic coronary artery disease

Keywords: autofluorescence narrow band high definition white light
dimensional changes of peri-implant tissue in immediate implants with individualized healing abutments

Conditions: Dental Implant; Immediate Dental Implant; Wound Heal

Summary: the loss of a tooth leads to a series of biological changes in the tissues, resulting in bone resorption and gingival collapse. to avoid these problems, it has been proposed to place immediate post-extraction implants, allowing a reduction in treatment time and the number of surgeries, as well as better maintenance of the tissues. this technique can be performed with standard abutments after implant placement or, more recently, the use of temporary abutments has been proposed.

objective: to check if custom healing abutments manufactured using cad/cam technique in immediate implants promote greater dimensional stability of the peri-implant tissue compared to standard healing abutments. methods: after the extraction, an immediate klockner vega+ implant will be placed and the gap will be filled with a bone substitute (cerabone, botiss). the patient will then be randomized to the control group (standard healing abutment) or the test group (custom healing abutment using cad/cam technique). in the latter case, a peripheral seal is achieved, allowing for wound closure and stabilization of the clot with the same shape as the crown in its transmucosal part.

Eligibility criteria:
inclusion criteria: * adult patient ( 25 years old). * need for extraction of an irrational tooth to be treated in the molar/premolar position of the upper/lower arch. * presence of 2mm of keratinized gingiva. * bone dehiscence in the alveolar walls of 2 mm. 2 mm. * adequate amount of bone in the interradicular septum to stabilize the implant (minimum height 10 mm, minimum width 4 mm at the base of the septum). * plaque index (fmspi, full mouth score plaque index) \< 10%. * non-smokers or smokers of less than 10 cigarettes per day. * absence of systemic diseases that contraindicate implant surgery. exclusion criteria: * presence of alveoli with dehiscence \>2mm. * presence of adjacent implants. * \< 2mm of keratinized gingiva. * presence of active infection (fistula, suppuration) at the extraction site. * presence of apical granuloma \>2mm in diameter in the root(s) of the tooth or teeth to be extracted. * residual bone apical to the extraction insufficient to anchor the implant. * pregnant or lactating women. * severe cognitive or psychiatric disorders. * compromised general health status ( asa iv). * use of drugs that alter bone metabolism and healing. * absence of manual primary stability of the implant * bone dehiscence or fenestration after implant placement (manual rotation). * gap 2mm between the implant and the vestibular bone wall.

Keywords: implant soft tissue
manual therapy and augmented exercise for neck pain

Conditions: Neck Pain

Summary: manual therapy and exercise have shown to be beneficial for people with neck pain, however it is not clear how outcomes following a general exercise program compare to specific exercises intended to augment a specific manual/hands-on intervention. this study will compare outcomes following manual therapy and a specific exercise program with manual therapy and a general exercise program.

the purpose of this study is to determine if specific neck exercises intended to augment specific manual therapy treatments result in better outcomes than standard neck exercises in people with neck pain. clinical tests and measurements as well as patient questionnaires will be completed and compared between groups. a secondary purpose is to determine if self report of activity is correlated with functional improvements. we hypothesize that a specifically applied home exercise that augments the effects of the manual therapy intervention will lead to improvements in outcomes in patients with neck pain. we hypothesize that higher reports of self activity will be correlated with improvements in outcomes.

Eligibility criteria:
inclusion criteria: * subjects with complaint of neck pain, neck motion limitations, pain at end-range neck rom, limited cervical/cervical and thoracic joint mobility, neck pain with manual segmental examination exclusion criteria: * the presence of any red flags (i.e. tumor, metabolic diseases, rheumatoid arthritis, osteoporosis, prolonged history of steroid use, signs and symptoms of vertebrobasilar insufficiency, etc.), use of blood thinners, whiplash injury in the past 6 weeks, evidence of central nervous system involvement (such as hyperreflexia, sensory disturbances in the hands, unsteadiness during walking, etc.), history of spinal surgery, workers compensation or pending legal action regarding their neck pain, insufficient english language skills to complete questionnaires, unable to comply with schedule

Keywords: augmented exercise cervicalgia manual therapy manipulation quantitative sensory
radiation dose among different endovascular procedures: the rodeo study

Conditions: Radiation Injuries

Summary: retrospective multicenter study aimed to evaluate radiation exposure associated with different interventional procedures involving interventional cardiologists, interventional radiologists and electrophysiologists.

the use fluoroscopically guided interventional procedures is progressively increasing over the past 20 years.some previous reports have shown that the radiation dose absorbed by interventional cardiologists is the greatest registered by any medical staff exposed to x-rays. however in recent years new procedures have been introduced and validated in the setting of interventional cardiology and radiology and there is wide variation in patient dose among different procedures. radiation issue is an important issue for patients and operators due to the acute deterministic effects and most important for the long term stochastic risk of cancer induction: however this problem is often under-evaluated. even if the stochastic risk is an all-or-none phenomenon for any individual cell, the greater the radiation exposure, the more cells are injured. moreover non cancerous effects are possible such as cataract formation in the eye and the probability increases with increasing dose. radiation dose can be expressed in different ways: the air kerma is the amount of energy absorbed in a given mass of air, whereas the dose area product (dap) is the absorbed dose of radiation across a given surface area. generally dap measurements are more accurate than using air kerma measurements for the estimation of patient radiation dose as dap allows for variations in field size. dap consents a good estimation of the dose to the irradiated tissue and is an indicator for patient cancer risk. aim of our study is to evaluate the radiation dose exposure during different fluoroscopically guided interventional procedures comparing different specialties (electrophysiology, interventional radiology, interventional cardiology). methods from january 2013 to december 2015 all diagnostic or interventional procedures performed by interventional operators will be included in this multicenter study without exclusion criteria. collection of data will be retrospective in a dedicated database. radiation exposure will be assessed measuring the dap and fluoroscopy times for each procedure. moreover for each procedure all the centers are requested to give information about operator, patient and procedure details. end point of the study the primary end-point of the study is the comparison of dap dose among interventional cardiologist, electrophysiologist and interventional radiologist procedures. secondary end-point of the study is to compare fluoroscopy times among different procedures.

Eligibility criteria:
inclusion criteria: * all procedures for which dap values are available exclusion criteria: * procedures without dap

Keywords: radiation dose percutaneous coronary intervention coronary interventional radiology electrophysiology
efficacy and safety of tripterygium wilfordii in patients with lupus nephritis

Conditions: Nephritis, Lupus

Summary: evaluation the clinical efficacy and safety profile of glucocorticosteroid combined with oral t2 (chloroform/methanol extract of tripterygium wilfordii hook f) in the treatment of patients with lupus nephritis. open-labeled, randomized, prospective multi-center clinical trial. observation period of 24 weeks.


Eligibility criteria:
inclusion criteria: * age 18-65 years with informed consent * sle defined by meeting 4 or more acr classification criteria * biopsy-proven active proliferative lupus glomerulonephritis isn classification class iii or iv * active renal disease exclusion criteria: * pregnant, lactating or further fertility requirements * serum creatinine \> 3 mg/dl * serum alt or ast \> 3 times upper limit of normal * severe, progressive renal, hepatic, hematological, gastrointestinal, pulmonary, cardiovascular, neurological, endocrine or cerebral disease * previous treated with cyclophosphamide or t2. * not discontinuing mmf, azathioprine, leflunomide, methotrexate, calcineurin inhibitor before 1 month of randomization. * active or chronic infection, including hiv, hcv, hbv, tuberculosis * patient with malignancy

Keywords: lupus nephritis cyclophosphamide tripterygium
efficacy and safety study of entecavir plus tenofovir in patients with chronic hepatitis b who failed previous treatment

Conditions: Chronic Hepatitis B

Summary: the purpose of this study is to show that the combination of entecavir and tenofovir, is effective and well tolerated in chronic hepatitis b patients who have failed previous treatment.


Eligibility criteria:
inclusion criteria: * subjects with chronic hepatitis b virus (hbv) infection; either hepatitis b-e antigen(hbeag)-negative or hbeag-positive * subjects must have a treatment failure to their current nucleoside/ nucleotide treatment regimen * prior entecavir and/or tenofovir monotherapy is allowed * subjects must have compensated liver function exclusion criteria: * women who are pregnant or breastfeeding * evidence of decompensated cirrhosis * co-infection with hiv, hepatitis c virus (hcv), or hepatitis d virus (hdv) * moderate or severe renal impairment * recent history of pancreatitis * therapy with interferon, thymosin alpha or other immuno-stimulators within 24 weeks of being assigned to study drug into this study * prior entecavir/tenofovir combination therapy
fast magnetic resonance imaging as compared to computed tomography scan in pediatric orbital cellulitis imaging

Conditions: Orbital Cellulitis

Summary: the aim of the study is to compare orbital and central nervous system (cns) imaging with computed tomography (ct) scan to that of fast magnetic resonance imaging (fast mri) in children with mild, moderate or severe orbital cellulitis with medical indications for imaging.


Eligibility criteria:
inclusion criteria: * children with orbital cellulitis with indications for imaging exclusion criteria: * all others
post-marketing surveillance for hypertensive patients with diabetes and/or chronic kidney disease

Conditions: Hypertension

Summary: this study is a post-marketing surveillance in japan, and it is a local prospective, company sponsored and observational study of patient who have been treated by adalat cr for hypertension with diabetes and/or chronic kidney disease. the objective of this study is to assess safety and efficacy profile of using adalat cr in real clinical practice. a total 2,000 patients will be recruited and be observed for 6 months. then, patient of whom microalbumin urea and serum creatinine are continuously monitored are additionally followed for 6 months.


Eligibility criteria:
inclusion criteria: * patient who are administered with adalat cr for hypertension with diabetes and/or chronic kidney disease (ckd) exclusion criteria: * ckd with stage 5 * cdk with dialysis

Keywords: adalat hypertension diabetes chronic kidney disease
clinical features and prognostic markers in adult patients with ae requiring icu treatment

Conditions: Autoimmune Encephalitis

Summary: autoimmune encephalitis (ae) is a potentially life-threatening inflammation of the central nervous system (cns) and constitutes 20%-30% of encephalitis cases in adults ae often leads to subacute, severe, and debilitating encephalitis necessitating long-term management in a neurologic intensive care unit (icu). this study aims to explore the predictive factors for poor clinical outcomes by analyzing the clinical characteristics and prognosis of adult patients with critical ae requiring icu admission. prospective observational single center study in neurologic icu, the second xiangya hospital, central south university. all patients admitted to the icu for probable or confirmed ae (2022 chinese guidelines for diagnosis and treatment of ae) will be included. factors associated with a poor prognosis will be identified by multivariate analysis using a logistic regression.


Eligibility criteria:
inclusion criteria: * diagnosed as either ''definite'' or ''probable'' ae based on chinese guidelines for diagnosis and treatment of ae (version 2022) * age ≥ 15 years * admission to an adult icu during the course of the disease exclusion criteria: * missing data on primary outcome * icu length of stay of 24 hours or less.
a study of two different doses of abt-378/ritonavir in hiv-infected patients who have taken protease inhibitors and non-nucleoside reverse transcriptase inhibitors

Conditions: HIV Infections

Summary: the purpose of this study is to determine the safety and effectiveness of a high dose of abt-378/ritonavir


Eligibility criteria:
inclusion: * hiv positive * are at least 18 years old * subject has not been treated for an active aids-defining opportunistic infection within 15 days of screening * hiv rna level \> 1000 copies/ml * previous therapy with at least one protease inhibitor, at least one non-nucleoside reverse transcriptase inhibitor and at least one nucleoside reverse transcriptase inhibitor exclusion: * subject is pregnant or breast-feeding * subject has received an investigational drug within 30 days prior to screening * have a history of pancreatitis * history of intolerance to ritonavir * abnormal laboratory tests at screening

Keywords: hiv
internet-based exposure-based therapy for fibromyalgia: a randomized controlled trial.

Conditions: Fibromyalgia

Summary: the purpose of this study is to examine if an internet-based exposure therapy is effective in reducing fibromyalgia symptoms and impact amongst patients with fibromyalgia.

trial objectives: primary objective is to investigate whether an internet-based exposure therapy can effectively reduce the degree of fibromyalgia symptoms and impact. secondary objectives are to 1) investigate the treatment's ability to reduce degree of a) quality of life b) function c) insomnia and fatigue d) pain-related fear and negative thoughts e) depression and anxiety, cost-effectiveness of this treatment; and 2) to study if any variables could moderate/mediate the treatment outcome, such as a) degree of covert avoidance, b) degree of reactivity to inner sensations trial design: randomized controlled trial with waitlist control, who also will receive treatment after the first group has finished. duration: ten weeks primary endpoint: change in fibromyalgia symptoms and impact from baseline to week 10. long term follow-up is also investigated (potential changes from post-treatment to 6- and 12 months after treatment completion) efficacy parameters: the fibromyalgia impact questionnaire (fiq) description of trial subjects: patients \> 18 years old, fibromyalgia diagnosis, residing in sweden. number of subjects: 140 sample size estimation: sample size is based on a estimated effect size (measured by cohen's d) of 0.5, based on a power of 0.8 and with room for a 10 % dropout rate. recruitment: self-referral. advertising will be made through national newspaper, social media and on patient organisations' websites. safety parameters: participants will have the opportunity to report any adverse events during treatment at posttreatment and follow-up measurements. data collection: data will be collected electronically via the treatment platform. plan for missing data: last-observation carried forward (locf). main statistical analysis: hierarchical linear mixed modelling.

Eligibility criteria:
inclusion criteria: * fibromyalgia diagnosis * swedish resident * internet connection before, under and after treatment * willing to refrain from other concurrent psychological treatment during the study * agreement to keep psychotrophic medication constant during the study exclusion criteria: * severe depression (≥30 points on montgomery åsberg depression rating scale - self rated (madrs-s) or risk of suicide (≥4 points on the suicide item on madrs-s) * ongoing alcohol or substance abuse * psychosis * other severe illness that require immediate treatment and/or was considered the participants primary concern other than fm, or bodily condition that makes treatment unfeasible (such as late pregnancy; \>29 weeks gestation * illiteracy or poor skills in swedish language * insufficient computer or language skills to manage a text-based treatment. * other concurrent psychological treatment * recent changes in psychotrophic medication (\<6 weeks prior to randomization)

Keywords: cognitive behavior therapy randomized controlled trial exposure therapy fibromyalgia