Kornimate/medical-research-clean huggingface dataset:
double-blind, randomized controlled study to assess the analgesic effect of 2 g of magnesium dipyrone (metamizol) and changes in plasma beta-endorphin immunoreactivity values in patients undergoing elective inguinal herniorrhaphy under epidural anesthesia.

Conditions: Pain; Beta-endorphin; Dipyrone; Hernia Surgery

Summary: a double-blind, randomized controlled study is designed to assess the analgesic effect of a single intravenous dose of 2 g of magnesium dipyrone (metamizol) and whether the administration of the active drug will be associated with changes in plasma beta-endorphin immunoreactivity values in patients undergoing elective inguinal herniorrhaphy (bassini operation) under epidural anesthesia. participants, care givers, and those assessing the outcomes will be blinded to group assignment. participants will be randomized to receive dipyrone or a placebo. the active drug or placebo will be administered as an intravenous infusion over 10 min. pain will be evaluated by the patient according to a 100-mm visual analogue scale. assessments will be carried out the day before surgery, immediately after operation, at the time of drug administration, and 60 and 180 min after treatment. at the same time as pain will be evaluated, blood samples will be drawn for plasma beta-endorphin immunoreactivity measurement (immunoradiometric assay).


Eligibility criteria:
inclusion criteria: * 18-70 years, elective surgery, routine laboratory tests (blood cell count, biochemical profile, urinalysis), chest radiography, twelve-lead electrocardiography, body mass index (bmi), blood pressure, pulse rate normal or abnormal values without clinical relevance and a mental status sufficient to be able to complete efficacy tests. exclusion criteria: * patients who had taken other analgesics or anti-inflammatory drugs 24 h before surgery, as those with known hypersensitivity to the drug or with any other disorder contradicting the administration of dipyrone. patients with hypersensitivity to non-steroidal anti-inflammatory agents.
comparison of therapy in treatment of patients with helicobacter pylori infection: concomitant versus hybrid therapy.

Conditions: Helicobacter Pylori Infection

Summary: the aim of the study is to compare the effectiveness of two therapeutic protocols in the treatment of helicobacter pylori infection. the hypothesis of our research is that the two therapeutic options (hybrid and concomitant therapy) will be equally successful in the treatment of helicobacter pylori infection. in other words, in both therapeutic groups we expect successful treatment of helicobacter pylori infection in or more than 90 % of patients. in other studies, both therapeutic options have the same efficacy in treating h. pylori infection. on the other had there are no studies available in croatia to compare the effectiveness of these therapeutic options so far, which is the main objective of our research. the secondary goals of our study will be: the existence of differences in the occurrence of possible side effects, as well as the compliance between patients in both therapeutic options. it is also our aim to compare the quality of life of patients with helicobacter pylori infection before and after treatment, via a questionnaire that is common for this purpose. the study is expected to include a total of 120 patients (60 patients in each therapy group), and the planned duration is 12 months.


Eligibility criteria:
inclusion criteria: * helicobacter pylori infection (documented by: positive antigen stool test, or positive urease rapid test obtained during upper endoscopy, or helicobacter pylori in histological finding, or positive c-urea breath test; according to recent maastricht v guidelines; * written informed consent exclusion criteria: * age under 18 * previously treatment of helicobacter pylori infection * malignancy of stomach or other site * history of taking proton pump inhibitors, h2 antagonist, bismuth or antibiotics (amoxicillin, metronidazole, clarithromycin) in previous month * significant underlying disease (renal failure, psychiatric disorders) * history of allergic reactions to any medications used in study * refuse to participate in study * breastfeeding and pregnancy * quitting the study

Keywords: helicobacter pylori, eradication, hybrid therapy, concomitant therapy
kappa index versus csf oligoclonal bands in diagnosis of ms and prediction of disease activity

Conditions: Multiple Sclerosis

Summary: to: 1. compare the diagnostic performance of cerebrospinal fluid kappa index to that of cerebrospinal fluid igg oligoclonal bands in differentiating multiple sclerosis from other inflammatory and non-inflammatory neurological diseases . 2. assess the role of kappa free light chain and oligoclonal bands in predicting disease activity (conversion from clinical isolated syndrome to multiple sclerosis)

multiple sclerosis is a chronic inflammatory immune-mediated disorder of the central nervous system.diagnosis requires the combination of clinical signs and symptoms with paraclinical findings obtained by magnetic resonance imaging and cerebrospinal fluid analysis .which are componants of the 2017 mcdonald criteria .so far, the gold standard for demonstrating intrathecal igg synthesis is represented by selective oligoclonal bands in cerebrospinal fluid by isoelectric focusing (ief), alongside an elevated igg index .however, the detection of oligoclonal bands in cerebrospinal fluid has several limits as , it requires a time-consuming and expensive laboratory technique, with about three hours needed to obtain results furthermore, it only provides aqualitative information about the presence of igg in csf .during cns inflammation , kappa free light chain are secreted in the csf and their concentration reflect the degree of intrathecal b cells and plasma cells activation .measurement of kflc could help diagnosis of ocb negative ms and identify intrathecal immunoglobulin synthesis in patient presenting with one isolated band on isoelectric focusing , and it is fully automated,rater independent, stable against preanalytical errors . thus, the intrathecal synthesis of free light chains are more sensitive, less costly, and less time-consuming compared to ocb detection .the most reliable parameter used to assess flc diagnostic value in ms is the k-index, .so κ-flc index predicted the time to conversion to ms as well as disability progression . so patients with early ms and high κ-flc index is an independent risk factor for conversion from cis to ms

Eligibility criteria:
inclusion criteria: * patients diagnosed with cis or ms according to the 2017 revision of the mcdonald criteria * patients diagnosed with ris (radiological isolated syndrome) according to the criteria by okuda * age between 18 and 40 years. exclusion criteria: * history of exposure, in the 30 days prior to csf collection, to immunosuppressant or immunomodulatory therapies . * peripheral neurological disorders . * infectious cns disease. * cns tumor. * monoclonal gammopathy . * chronic kidney injury (gfr \<30 ml /min/1.75m2 )
statin therapy results in the real world practice in the czech republic

Conditions: Dyslipidaemia

Summary: statins are the first choice treatment of dyslipidemia, a major contributor to cardiovascular diseases. statins also have enough evidence to demonstrate decrease of morbidity and mortality from cardiovascular diseases. even though statin therapy is effective treatment of dyslipidaemia not all patients reach the goal levels. the aim of the study is to estimate proportion of patients who achieved the therapeutic goal (ldl-c. total cholesterol, hdl-c and triglycerides levels) after at least one year of a statin therapy.


Eligibility criteria:
inclusion criteria: * documented statin therapy for at least 12 months * available two ldl-c values: one at the beginning of statin therapy or at the time when patient comes to a specialist; and the other one at least after 12 months of treatment. the latter value should not be older than 6 months. exclusion criteria: -

Keywords: statin therapy treatment goal dyslipidaemia
multifocal intraocular lens x monovision x hybrid monovision after bilateral cataract surgery

Conditions: Cataract; Presbyopia

Summary: to compare refractive outcomes and patient's visual quality after bilateral cataract surgery when implanting multifocal intraocular lens, monofocal with monovision or hybrid monovision.

the purpose of this study is to evaluate the results in randomized patients that receive bilateral multifocal iols, monofocal iols with monovision with emmetropia in one eye and 1.50 d of myopia in the other eye, or monofocal iol in the dominant eye and multifocal iol in the non-dominant eye, then evaluate visual and refractive outcomes, as well as independence for glasses after bilateral surgery with 1 year of follow up.

Eligibility criteria:
inclusion criteria: * bilateral senile cataracts. * implantation of iol in the capsular bag; * implants from 10-30 diopter; * potential visual acuity in ≥ 0.2 logmar (20/32, metric scale) after surgery; exclusion criteria: * amblyopia; * single eye; * history of intraocular surgery in the previous year; * sequel to prior ocular trauma; * important microphthalmia or aniridia; * history of damage to the corneal endothelium (chemical burns, herpetic keratitis, corneal guttata); * corneal astigmatism \> 1.0 d; * iop ≥ 21 mmhg in standard caliper; * ocular pathology that affects visual function (uveitis, diabetic retinopathy, age-related macular degeneration, macular dystrophy, retinal detachment, glaucoma, optic neuropathy); * pupil \> 5 mm or \< 2 mm under photopic conditions; * asymmetrical pupils in the eye or between the eyes; * binocular vision absence; * any situation that endangers the implant position in the capsular bag (post-traumatic zonular weakness, pseudoexfoliation, for example); * patient probably need to laser treatment of the retina; * patients whose expectations are unrealistic; * patients whose lifestyle involves high expectations of visual acuity (writer, driver, for example); * patients at risk of not meeting the clinical follow-up requirements (distance of travel difficulties, for example);

Keywords: multifocal iol monovision hybrid monovision spectacles independence
safety and efficacy study of allogeneic adipose-derived stem cells for treatment of lateral epicondylitis

Conditions: Tennis Elbow

Summary: the objective of this study is to evaluate the safety and efficacy of allogeneic adipose-derived stem cells (allo-asc) in patients with lateral epicondylitis.


Eligibility criteria:
inclusion criteria: 1. older than 19 years. 2. patients who are diagnosed as lateral epicondylitis (pain≥4 of vas during activity). 3. patients who has sustained pain more than 6 months 4. patients who lasting for pain in spite of conservative therapy 5. patients who have one lesion under ultrasonic photography 6. negative for urine beta-hcg for women of childbearing age 7. patient who is able to give written informed consent prior to study start and to comply with the study requirements exclusion criteria: 1. patients who has been experienced steroid and prolotherapy or other treatment within 3 months at screening time 2. patients who have lesion size of width and length more than 1 cm using ultrasonic photography test 3. patients who were accompanied by the disease as follows: a. arthritis of related joint to the target lesion (ex, cubital osteo- arthritis), b.synovitis of related joint to the target lesion, c.entrapment of related nerve to the target lesion(ex, radial tunnel syndrome), d.generalized pain syndrome, e.radiculopathy related to the target lesion(ex, cervical spodylosis ,cervical radicular syndrome), f.rheumatoid arthritis, g.previous fracture of arm causing limitations in arm function, h.impaired sensibility, i.paralysis 4. patients who are pregnant or breast-feeding 5. patients who have allergic or hypersensitive reaction to bovine-derived proteins or fibrin glue 6. patients who have history of fracture and dislocation at ipsilateral upper extremity within 2 years recently 7. patients who have operation history in tendon, ligament and bone at ipsilateral upper extremity within 2 years recently 8. patients who are unwilling to use an "effective" method of contraception during the study 9. patients who have a clinically relevant history of abuse of alcohol or drugs 10. patients who are considered not suitable for the study by investigator 11. patients who have experienced treatment with stem cell before this study 12. patients who currently enrolled in another investigational drug study within 30 days of screening

Keywords: lateral epicondylitis
transbronchial ablation for peripheral lung tumor

Conditions: Lung Cancer

Summary: the objective of the study was to evaluate the efficacy and safety of navigation bronchoscopy guided transbronchial ablation for the treatment of inoperable peripheral lung tumor.

the study is aimed to evaluate the efficacy and safety of navigation bronchoscopy guided transbronchial ablation for treating inoperable malignant lung tumor. the study is designed as a single-center prospective trial. the participating centers are department of pulmonary medicine and endoscopy, shanghai chest hospital,shanghai jiao tong university, china. patients are divided into two groups, including radiofrequency ablation group and microwave ablation group. sixty patients are expected to be enrolled into the study with 30 patients in each group.

Eligibility criteria:
inclusion criteria: 1. patients older than 18 year-old. 2. patients meeting one of the following criteria: 1) patients discovered with peripheral lung lesions that have demonstrated to be lung cancer by pathology with the clinical stage no later than iia. 2) recurrent or progressive single lesion or solitary intrapulmonary metastasis after surgery, radiotherapy, chemotherapy or other treatment.3) multiple primary lung cancer with the number of tumors no more than 5 and no metastasis. 4) pulmonary metastases with effective treatment of primary disease, the number of metastases no more than 5 and no other metastasis. 3. chest ct shows the length-diameter of the tumor is more than 8mm and no more than 50mm. 4. patients are unsuitable for surgery assessed by multidisciplinary team and agree to the primary treatment of ablation. 5. patients have good compliance and sign the informed consent. exclusion criteria: 1. patients cannot receive bronchoscopy for the severe cardiopulmonary dysfunction and other indications. 2. patients have contraindications of general anesthesia. 3. chest ct or bronchoscopy shows that guided and treatment instruments cannot reach the peripheral lung lesion. 4. there are large blood vessels or important structures adjacent to peripheral lung lesion. 5. researchers consider the patient do not fit for the study due to other reasons.

Keywords: lung cancer transbronchial ablation radiofrequency ablation microwave ablation
does a pre-operative exercise program improve post-operative outcomes for fusion patients

Conditions: Adolescent Idiopathic Scoliosis

Summary: a study found that in 1744 patients undergoing fusion surgery for adolescent idiopathic scoliosis, 12% had back pain remaining after recovering from surgery. rehabilitation prior to spine surgery or prehabilitation (prehab), has been shown to reduce costs and improve functional outcomes in patients who have had total hip or total knee arthroplasties. there is a lack of literature looking at prehab in the context of spine surgeries. the purpose of this study is to see if prehab can improve patient outcomes such as decreased pain, decreased length of stay in the hospital, and improved functional outcomes in patients undergoing fusion surgery for adolescent idiopathic scoliosis.

adolescent idiopathic scoliosis (ais) is the most common spinal deformity in adolescents and literature suggests that the link between back pain and ais is underreported. core stabilization exercises and scoliosis specific exercises have been shown to increase srs scores related to pain (higher srs scores indicate lower levels of pain). additionally, higher srs scores at pre-op were associated with a lower risk of residual postoperative pain following a fusion surgery. this suggests that preoperative exercise programs should lead to an increase in srs pain scores post-operatively however, this direct relationship has not been researched. rehabilitation exercises prior to surgery has been shown to improve functional outcomes in knee and hip arthroplasties however, the rehabilitation preoperatively has not been studies in the context of spine surgeries. the purpose of this study is to evaluate whether the prehabilitation exercise program can improve post-op outcomes including length of stay, decreased pain, decreased length of stay, and improved functional outcomes.

Eligibility criteria:
inclusion criteria: * included patients will have a diagnosis of ais (ages 11-18). they will have a curve angle requiring surgery and be on the waitlist for surgery. exclusion criteria: * patients will be excluded if they are currently enrolled in a physiotherapy designed exercise program prior to being enrolled in the study. * they will be excluded if they have additional medical issues, limiting their ability to participate fully in the exercise program. * individuals with any cognitive disability that affects their ability to complete the questionnaires or follow instructions for the exercise program will also be excluded.
high dose vitamin d study

Conditions: Colorectal Cancer

Summary: the purpose of this study is to investigate the therapeutic effect and the safety of high-dose vitamin d supplementation in metastatic colorectal cancer patients. we propose to supplement metastatic (stage 4) colorectal cancer patients with oral doses of vitamin d to raise serum 25-hydroxy-vitamin d \[25(oh)d\] levels to the high normal range of 200-250 nmol/l. the primary objective of this study is to evaluate the metabolic consequences, including tolerability and toxicity, of prolonged, high-dose physiological vitamin d in patients with colorectal cancer. the secondary objective is to evaluate patient survival with regards to high-dose vitamin d supplementation. hypothesis: whereas low doses of vitamin d reportedly play a significant role in prevention of colorectal cancers, do much larger (pharmacological) doses of vitamin d have a significant therapeutic effect against the same kind of cancer?

metastatic (stage 4) colorectal cancer patients who were randomly assigned to the treatment arm of this study will be orally supplemented with high doses of vitamin d to achieve serum 25(oh)d concentrations of 200-250 nmol/l (80-100 ng/ml). therefore, the supplementation dosage is not pre-set but will be determined on an individual basis. vitamin d supplementation will be continued for 16 months, followed by a 12 month follow up period. monthly monitoring of serum 25(oh)d and calcium levels will assure the safety of our treatment protocol. subjects in the control arm of the study will be receiving standard cancer care at inspirehealth that includes supplementation with at least 2,000 international units of vitamin d.

Eligibility criteria:
inclusion criteria (we will recruit stage 4 (metastatic) colorectal cancer patients who are clients at inspirehealth): * age \> 18 * histologically confirmed colon or rectal cancer * known metastatic disease (stage-4) confirmed histologically or radiologically * life expectancy of \>8 months * may receive anti-neoplastic therapy at the discretion of their physician * stable metastatic disease defined as no change in systemic for the month before and the month after commencing study * signed informed consent exclusion criteria(stage 4 colorectal cancer patients): * pregnant / lactating women * known hypersensitivity to vitamin d * pre-existing renal stone disease based on history * pre-existing hypercalcemia * severe renal or hepatic dysfunction (≥ 2x of the upper normal range) * granulomatous disease (tb and sarcoid) * unable to give informed consent in english (translations of study documents in languages other than english will not be provided)

Keywords: vitamin d vitamin d3 colon cancer rectal cancer cholecalciferol
examining effects of ocrevus on cognitive fatigue using fmri

Conditions: Multiple Sclerosis, Relapsing-Remitting

Summary: the purpose of this research study is to investigate the effectiveness of ms disease modifying medications on cognitive fatigue in persons with relapsing remitting multiple sclerosis (rrms). cognitive fatigue is the kind of fatigue that occurs after intense mental concentration as after a session of problem solving.

the researchers aim is to investigate the effects of disease modifying treatments on cognitive fatigue and on specific brain areas that have been shown to underlie cognitive fatigue in individuals with multiple sclerosis (ms). the researchers will investigate the effects on the cognitive fatigue that develops during the performance of a demanding task, and also on how cognitive fatigue changes as a function of duration of treatment.

Eligibility criteria:
inclusion criteria: * age between 18-64. * relapsing remitting multiple sclerosis * been newly prescribed a new disease modifying medication for ms (either ocrevus or copaxone) * or healthy volunteer who can speak english fluently. exclusion criteria: * history of head injury, stroke, seizures, or any other significant neurological event other than ms * flare up of ms symptoms within the past month. * history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of major depressive disorder. * pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and internal hearing aids \[cochlear implants\]), permanent eyeliner, implanted delivery pumps, or shrapnel fragments. * left handed. * not able to have an mri

Keywords: multiple sclerosis cognitive fatigue
prophylactic subhypnotic propofol for nausea and vomiting during for cesarean section under subarachnoid anesthesia.

Conditions: PREGNANCY

Summary: perioperative nausea and vomiting may occur in 50-80% of patients undergoing cesarean section. metoclopramide is a well known dopamine receptor antagonist that acts at the chemoreceptor trigger zone and is used effectively for the prevention and treatment of nausea and vomiting. propofol can antagonize serotonin receptors in the area postremal and is associated to a reduced incidence of postoperative nausea and vomiting. some studies have shown that propofol can prevent intraoperative nausea and vomiting during cesarean section. the control of risk factors and the pharmacological prophylaxis of nausea and vomiting reduces effectively their incidence. in this randomized, double blind, case-control study the efficacy of propofol alone, metoclopramide alone and in combination in controlling nausea and vomiting were compared. a risk factor control strategy was associated to each study group.


Eligibility criteria:
inclusion criteria: cesarean section without maternal or fetal suffering american society of anesthesiologists score i-ii 36 to 41 week of gestation bmi \< 35 hemoglobin \> 10 mg/dl no complications (gestational diabetes, colestasis) no acute or chronic gastrointestinal disorders (gerd excluded) no smoking or drug abuse during pregnancy no previous major abdominal surgery no previous complicated pregnancies fetal weight \> 2.5 kg exclusion criteria: emergency cesarean section with maternal or fetal suffering american society of anesthesiologists score iii-iv-v \ 41 week of gestation bmi \> 35 hemoglobin \< 10 mg/dl complications (gestational diabetes, colestasis) acute or chronic gastrointestinal disorders smoking or drug abuse during pregnancy previous major abdominal surgery previous complicated pregnancies fetal weight \< 2.5 kg

Keywords: nausea vomiting cesarean section prevention propofol