spatial location of breast cancer local recurrence after mastectomy

Conditions: Breast Cancer

Summary: rationale:to improve the definition of the target volume for radiotherapy of the chestwall after different types of mastectomy, the exact localization of regions at risk for a local recurrence should be known. however, there are currently insufficient data in literature showing where local recurrences occur after different types of mastectomy. objective: the primary objective of the proposed study is to determine whether the spatial, location of a breast cancer recurrence after mastectomy, differs for different types of mastectomy. study design: retrospective study evaluating spatial location and site of recurrences after mastectomy. study population: the investigators aim to include all breast cancer patients treated with mastectomy in the netherlands between 2003- 2008, and known to have experienced a local recurrence as the first site of failure. primary endpoint: spatial location of local recurrence (e.g., primary tumour bed, scar, skin, subcutaneous, nipple, areola, pectoral muscles).

rationale:to improve the definition of the target volume for radiotherapy of the chestwall after different types of mastectomy, the exact localization of regions at risk for a local recurrence should be known. however, there are currently insufficient data in literature showing where local recurrences occur after different types of mastectomy. objective: the primary objective of the proposed study is to determine whether the spatial, location of a breast cancer recurrence after mastectomy, differs for different types of mastectomy. secondary objectives are to assess whether tumour characteristics (e.g., molecular subtypes, lymphangio/lymphovascular invasion) and treatment-related factors (e.g., pmrtwith or without bolus, radiation volumes, doses) influence the site of recurrence and spatial location. study design: retrospective study evaluating spatial location and site of recurrences after mastectomy. study population: the investigators aim to include all breast cancer patients treated with mastectomy in the netherlands between 2003- 2008, and known to have experienced a local recurrence as the first site of failure. primary endpoint: primary endpoint: spatial location of local recurrence (e.g., primary tumour bed, scar, skin, subcutaneous, nipple, areola, pectoral muscles). other study parameters: first descriptive statistics will be performed to investigate whether there is a relation between the localization of the recurrence and the type of mastectomy: modified radical mastectomy (mrm), skin-sparing mastectomy (ssm), nipple sparing mastectomy (nsm).

Eligibility criteria:
inclusion criteria: * age 18 years and more at the time of breast cancer diagnosis. * proven histology of first invasive breast cancer * mastectomy as a surgical procedure for breast cancer (regardless of perioperative treatment). * having a local recurrence, as primary event * reast cancer diagnosis in the period 2003-2008. exclusion criteria: * non-epithelial histology. * primary metastatic breast cancer. * mastectomy for breast cancer recurrence after earlier breast conserving therapy. * synchronous breast cancer.

Keywords: mastectomy