Kornimate/medical-research-clean huggingface dataset:
effect of blueberries on bone turnover

Conditions: Osteoporosis, Postmenopausal; Bone Loss, Age-related

Summary: this study uses a bone labeling calcium tracer methodology to compare the dose-response effect of blueberry consumption on calcium retention and bone loss. post-menopausal women will receive food or beverage products containing freeze-dried blueberries in the amount equivalent to 0.75 (low), 1.5 (medium), and 3 cups (high) of fresh blueberries per day over a 42-day period. the hypothesis is that the polyphenolics found in blueberries will reduce calcium loss from bones.

participants will be dosed with ca-41, a rare long-lived radioisotope of calcium. after the equilibration of tracer in the body and its deposition in bones (150 days), subjects will be randomized to one of 6 dose sequences, all of which will begin with a 42-day baseline period. during baseline, 24-hour urine will be collected every 14 days. following baseline, subjects will enter a 42-day intervention period with one of three doses of blueberries equivalent to 0.75 (low), 1.5 (medium), and 3 cups (high) of blueberries per day. each dose will be provided in the form of freeze-dried blueberry powder incorporated in 2-4 foods or beverages per day. during the intervention, 24-hour urine will be collected weekly for 6 weeks except week 1. after intervention, subjects will enter a 42-day washout period, during which 24-hour urine will be collected every 3 weeks. the entire study duration will be 444 days for subjects who have not been dosed with ca-41 previously. in a crossover design, all subjects will complete three 42-day intervention periods corresponding to the three doses of blueberries (low, medium, and high), each followed by a 42-day washout period. the dose-response effect of continuous blueberry consumption over a 42-day period on bone resorption in healthy post-menopausal women will be studied by measuring the loss of ca-41 in urine by accelerator mass spectrometry.

Eligibility criteria:
inclusion criteria: * female subject is healthy * subject is \> 4 years past the onset of natural menopause or total hysterectomy exclusion criteria: * history of metabolic bone disease or low trauma fractures; * subject taking osteoporosis treatment drugs or glucocorticoids within 6 months of the beginning of the study; * subjects taking bisphosphonates within 2 years of the beginning of the study; * history of cancer, thromboembolisms, clotting disorders, uncontrolled hypertension, abnormal thyroid function, malabsorption syndrome, seizure disorders, or heart attack; * bmi \> 35 kg/m2; * subjects who will not comply with study interventions ; * subjects who will not stop taking natural product supplements of their own selection.

Keywords: bone health calcium osteoporosis polyphenolics
a study to evaluate the safety and effectiveness of the 217z laser with zyoptix for lasik

Conditions: Myopia; Astigmatism

Summary: a study to demonstrate the safety and efficacy of wavefront laser refractive surgery treatments for myopia and astigmatism.


Eligibility criteria:
inclusion criteria: * myopia with or without astigmatism. exclusion criteria: * contraindications to lasik.
real world study of bone metastases in patients with advanced breast cancer

Conditions: Breast Cancer Metastatic

Summary: by analyzing the clinical data of patients with advanced breast cancer with bone metastasis admitted to our center from january 1, 2021 to february 28, 2023, this study aims to understand the real-world clinical diagnosis and treatment of breast cancer with bone metastasis, including the epidemiology of bone metastasis, screening and diagnosis methods, selection of clinical treatment methods, and occurrence of sre. to explore the risk factors related to bone metastasis-free survival (bmfi). in addition, we will explore the use of quantitative analysis of ct values to evaluate bone metastases of breast cancer, aiming to provide a new method for imaging quantitative efficacy evaluation of bone metastases.

the specific contents of our research include the basic information of breast cancer patients with bone metastasis in the early stage, neoadjuvant therapy, surgery and postoperative pathology, and adjuvant therapy; the time and location of recurrence and metastasis, treatment plan, and information related to bone metastasis include time, location, diagnosis method, treatment, occurrence of sre, and changes in ct values of bone lesions before and after drug treatment. the objective is to understand the risk factors of bone metastasis-free survival (bmfi) of breast cancer patients with bone metastases in the real world, provide evidence and data for clinical accurate screening, observe the ct value changes of bone lesions through imaging (ct quantitative), and explore a new method for evaluating the efficacy of bone metastases.

Eligibility criteria:
inclusion criteria: 1. age ≥18y; 2. advanced breast cancer is clearly diagnosed; 3. imaging or pathology confirmed at least 1 bone metastasis; 4. no history of other malignant tumors at the time of initial diagnosis; 5. the physical status score of eastern tumor collaboration group (ecog) was ≤2 points; 6. complete clinical and follow-up data. exclusion criteria: exclusion is defined as meeting 1 of the following exclusion criteria: 1. patients with other malignant tumors; 2. history of hyperthyroidism and hypothyroidism, abnormal parathyroid function; 3. history of bone metabolic diseases.
effectiveness of mobilization with movement along with sensory motor training in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: to find out the effectiveness of mobilization with movement along with sensory motor training in patients with knee osteoarthritis


Eligibility criteria:
inclusion criteria: * both genders between age of 45 and 70 with knee pain more than 3 months of presentation in outpatient department. they were also required to stand independently from sitting and prone lying exclusion criteria: * patients with any lower limb fractures, any neurological condition, contraindication to manual therapy, post traumatic knee osteoarthritis, total knee replacement, uncontrolled hypertension, and radiating leg pain
prognostic value of adipokine levels of patients with chronic heart failure

Conditions: Chronic Heart Failure

Summary: the purpose of this study is to determine whether expressions of adipokines can provide prognostic information concerning patients with chronic heart failure.


Eligibility criteria:
inclusion criteria: * patients who are giving open chest surgical treatment with a history of chronic heart failure (nyha ii \~ iv) more than 6 months. * patients from whom informed consent has been properly obtained in writing prior to start of the trial. exclusion criteria: * patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases,or any other malignancy. * patients with a history of cardiomyopathy. * patients with chronic arrhythmia. * pregnant women * severe hepatic dysfunction or end-stage renal failure. * uncontrolled hypertension.

Keywords: adipokines chronic heart failure prognosis
macrophage migration inhibitory factor for diagnosing endometriosis and its severity

Conditions: Endometriosis

Summary: endometriosis is a chronic disease affecting women of reproductive age. macrophage migration inhibitory factor (mif) is one of non-invasive blood biomarker that was detected in sera of endometriotic patients.the aim of this study was to evaluate the value of serum macrophage migration inhibitory factor in diagnosing endometriosis in women with infertility and chronic pelvic pain and correlate its level with the stage of the disease. three hundred patient candidate for diagnostic laparoscopy were included in a case-control observational study

observational case-control study conducted in fayoum university hospital from march 2016 till september 2018. three hundred women candidate for diagnostic laparoscopy for either infertility or gynecologic chronic pelvic pain were included. the study group included patients with diagnostic criteria of endometriosis. the control group included other causes of infertility or pelvic pain.

Eligibility criteria:
inclusion criteria: * postmenstrual women * in childbearing period, * presenting with either gynecologic chronic pelvic pain (cpp) or infertility * indicated and fit for diagnostic laparoscopy. * all women must have no hormonal treatment for the last 3 months and. exclusion criteria: * women with bleeding tendency, * suspicious of gynecologic malignancy or * active infection

Keywords: macrophage migration inhibitory factor endometriosis laparoscopy
impact of percutaneous transvenous mitral commissurotomy on the left atrial appendage function in patients with mitral stenosis.

Conditions: Mitral Stenosis

Summary: • evaluation of the effect of ptmc on laa function by tee at least one month after the procedure and its effectiveness in prevention of thrombi formation and cerebrovascular complications.

* mitral stenosis (ms) is a disabling disease that limits the normal physical abilities of patients and considered as a major reason for hospital admissions . the leading cause of ms globally is rheumatic heart disease(rhd), which remains common in economically developing countries and continues to be a significant cause of morbidity and mortality. * chronic pressure and volume overload imposed by ms causes left atrial (la) and left atrial appendage (laa) dysfunction leading to reduced blood flow velocities thereby producing stasis of blood, reduced la and laa ejection fraction and atrial fibrillation (af). * these factors predispose to formation of la and laa thrombi in ms and result in thromboembolic episodes. risk of cerebrovascular accident (cva) is increased approximately five-fold in non-rheumatic af and 17-fold in patients with ms with af. even patients of ms in sinus rhythm with depressed la and laa function are at increased risk of cva. assessment of laa function is helpful in predicting the risk of thromboembolism . * ptmc can improve the function of the laa by reducing the left atrial pressure and increasing the blood flow through the mitral valve. * echocardiography, particularly transesophageal echocardiography (tee), is currently the modality of choice for evaluation of the laa. transesophageal echocardiography (tee) allows semi-invasive, highly accurate imaging of the functional efficiency of laa by laa doppler and doppler tissue imaging (dti) . * ms causes decreased laa doppler and dti velocities in patients even with sinus rhythm . so, this study aims to evaluate effect of successful ptmc on laa function by tee doppler and dti (doppler tissue imaging). * fractional area change (fac): the fac is a measure of the percentage of change in the area of the laa during systole. a higher fac indicates a more contractile laa.

Eligibility criteria:
inclusion criteria: * • patient eligible for ptmc as anatomical characteristics àpatient with sever ms (area 1.5cm2, echocardiographic score (wilkins score ≤ 8, cormier score 1 and 2 ...), contraindication or high risk to surgical mvr. exclusion criteria: * patient with mitral regurgitation more than grade ii . * patient not eligible to ptmc. * patient with severe heart failure (nhya class iv) . * patient with previous cerebrovascular accident . * patient with contraindication to tee ( esophageal disease like stricture , diverticuli, varices, ..., uncooperative patient )
teprotumumab (rv 001) treatment in patients with active thyroid eye disease

Conditions: Thyroid Associated Ophthalmopathies; Thyroid-Associated Ophthalmopathy

Summary: the primary objective of this study is to investigate the efficacy, safety, and tolerability of rv 001 (teprotumumab), a fully human anti-igf1r antibody, administered q3w for 6 months, in comparison to placebo, in the treatment of participants suffering from active ted. "funding source - fda oopd"

study with completed results acquired from horizon in 2024.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of graves' disease associated with active ted and a clinical activity score of ≥ 4 * fewer than 9 months from onset of ted * no previous medical or surgical treatment, excluding local supportive measures and oral steroids if the maximum cumulative dose is less than 1000 mg methylprednisolone or equivalent with at least 6 weeks between last administration of oral steroids and randomization * euthyroid or with mild hypo or hyperthyroidism defined as free thyroxine (ft4) and free triiodothyronine (ft3) levels less than 50% above or below the normal limits (every effort should be made to correct the mild hypo- or hyperthyroidism promptly) exclusion criteria: * optic neuropathy * corneal decompensation unresponsive to medical management * oral or iv steroid treatment for any non-ted reason in the preceding 3 months * poorly controlled diabetes * platelets \< 100 x 10\^9/l * hemoglobin concentration \> 2 g/dl below the lower limit of normal

Keywords: thyroid eye disease, graves orbitopathy, thyroid associated ophthalmopathy
comparison of the i-gel, supreme and proseal lma in paralyzed patients

Conditions: Airway Complication of Anaesthesia

Summary: the investigators aimed to compare of the i-gel, supreme and proseal laryngeal mask airways in paralysed patients undergoing gynaecological laparoscopic surgery with oropharyngeal leak pressure. the investigators also studied their relative ease of insertion, time to insertion and complications of use as secondary outcome measures.

a total of 105 patients scheduled for elective gynaecological laparoscopic procedures in our inonu university medical faculty hospital were recruited.they were equally randomized into three groups: plma, supreme and i-gel groups. all three devices were compared with regard to oropharyngeal leak pressure, number and duration of insertion attempts and complications of airway. oropharyngeal leak pressure will evaluate including to start,trendelenburg and postoperative at period. fiberoptic evaluation of the lma's position were performed after successful insertion and determination of the airway pressures. after one hour patients were evaluated by a blinded independent observer for postoperative complications ( sore throat, dysphonia and dysphagia).

Eligibility criteria:
inclusion criteria: * 18- 60 years exclusion criteria: * asa 3-4 patients * bmi 40

Keywords: airway management
evaluation of effect of exercise on prescription

Conditions: Metabolic Syndrome X; Diabetes Mellitus, Type 2; Cardiovascular Diseases

Summary: the purpose of this study is to evaluate the effect of a primary healthcare intervention called 'exercise on prescription' aimed at increasing level of physical activity in a population of sedentary patients with increased risk of developing lifestyle diseases. the effect is evaluated using both objective and patient-reported variables.

exercise prescriptions are used for initiating a physical active lifestyle in sedentary populations. a danish project called 'exercise on prescription' (eop) is implemented in primary healthcare. patients eligible for eop are non-institutionalised adults with medically controlled lifestyle diseases or risk factors of lifestyle diseases, who are motivated to change lifestyle, able to improve health status through a physical active lifestyle, and willing to pay a fee of €100 for the intervention. the purpose of this study is to assess the effect on: 1) maximal oxygen uptake (vo2max), 2) bodyweight and body mass index, 3) glycemic control (in patients with impaired glucose tolerance), 4) physical activity level, and 5) health related quality of life. the eop-group is compared to a control group.

Eligibility criteria:
inclusion criteria: * all patients referred to the exercise on prescription scheme by their general practitioner * volunteer to participate in the randomized trial

Keywords: exercise exercise referral lifestyle diseases sedentary behavior
stepping training using feedback in stroke

Conditions: Cerebrovascular Accident

Summary: * are there differences in immediate effects of stepping training with and without the use of visually weight-taking machine (vwtm) on variables relating to well-controlled walking and walking symmetry in ambulatory patients with stroke? * are there differences of 4-week stepping training with and without the use of vwtm on variables relating to well-controlled walking and walking symmetry in ambulatory patients with stroke?

* to compare immediate effects of stepping training with or without the use of vwtm on variables relating to well-controlled walking and walking symmetry in ambulatory patients with stroke. * to compare effects of 4-week stepping training with or without the use of vwtm on variables relating to well-controlled walking and walking symmetry in patients with stroke.

Eligibility criteria:
inclusion criteria: * subjects are independent ambulatory patients with first stroke episode with the age at least 45-74 years old, * subacute (post-stroke time \< 6 months) or chronic (post-stroke time ≥ 6 months) stroke * independent walking at least 10 meters with or without a walking device * able to follow verbal command used in this study exclusion criteria: * the subjects who have other medical conditions that might affect participation in the study such as uncontrolled underlying diseases (i.e. hypertension, heart disease, thyroid, etc.), deformity in the lower extremities, pain more than 5 out of 10 on a visual analog scale, legally blind or had a history of visual deficits that were unable to be corrected by glasses or contact lens, have a color blindness and inability to communicate or follow the commands used in this study

Keywords: feedback physical therapy
atorvastatin as an adjunct to dfdba in intrabony defects

Conditions: Chronic Periaortitis; Intrabony Periodontal Defect

Summary: periodontitis is a major oral health problem which leads to the progressive destruction of periodontal ligament and alveolar bone with pocket formation, recession or both. the ultimate goal of periodontal therapy is to regenerate the lost periodontal tissue. the most common form of regenerative periodontal therapy is the use of bone grafts which stimulate bone formation by the processes of osteoinduction and osteoconduction. statins are a group of lipid lowering drugs which inhibit bone resorption by inhibition of the enzyme hmg-coa reductase. they also stimulate new bone formation by local stimulation of bmp-2, a major bone growth regulatory factor. they also have anti-inflammatory and anti oxidant properties. very few studies exist evaluating the beneficiary effects of grafts if combined with the statins which might enhance the regeneration by bone grafts. hence, the present study was carried out in an attempt to comparatively evaluate clinically and radiologically, the efficacy of atorvastatin gel as an adjunct to allograft in the treatment of intrabony defects.

a total of 26 intrabony defects in patients with chronic periodontitis as diagnosed by radiographs, were selected for the study after taking an informed consent. the selected sites were randomized in 2 treatment groups. group i - sites were treated with allograft (dfdba) group ii - sites were treated with allograft (dfdba) in combination with atorvastatin gel. clinical parameters like probing depth and clinical attachment level and radiological assessment of intrabony defect fill were done at baseline and 3 and 6 months postoperatively.

Eligibility criteria:
inclusion criteria: 1. systemically healthy individual based on personal and medical history. 2. presentation of untreated chronic periodontitis with intrabony defect having probing pocket depth (ppd) ≥5mm or clinical attachment loss of ≥ 3mm and radiographic signs of angular bone loss. exclusion criteria: 1. patients diagnosed and treated for systemic disease 2. pregnant and lactating women 3. smokers 4. history of allergy to statin group or patients on systemic statin therapy. 5. history of antibiotic or periodontal therapy for the past 6 months.

Keywords: chronic periodontitis atorvastatin intrabony defect
the efficacy of adductor-canal-blockade on pain and morphine consumption after total knee arthroplasty

Conditions: Postoperative Pain; Knee Arthroplasty

Summary: the objective of this study is to assess the efficacy of adductor-canal-blockade on pain and morphine consumption after total knee arthroplasty. our hypothesis is that the adductor -canal-blockade is superior to placebo in reducing pain and morphine consumption after total knee arthroplasty.


Eligibility criteria:
inclusion criteria: * total knee arthroplasty in general anaesthesia * asa 1-3 * bmi 18-40 * written informed consent exclusion criteria: * can not cooperate to the exam * do not speak or understand danish * drug allergy * alcohol or drug abuse * daily consumption of strong opioids

Keywords: adductor-canal-blockade postoperative pain us-guided nerve block total knee arthroplasty
safety of recombinant factor xiii (rfxiii) in healthy japanese volunteers

Conditions: Acquired Bleeding Disorder; Cardiac Surgery Requiring Cardiopulmonary Bypass; Healthy

Summary: this trial is conducted in japan. the aim of this trial is to investigate the safety profile of recombinant factor xiii (rfxiii) assessed by the occurrence of adverse events in healthy japanese subjects. in addition pharmacokinetic parameters will be investigated.


Eligibility criteria:
inclusion criteria: * good general health based on assessment of medical history, physical examination, ecg (electrocardiogram) and clinical laboratory data at screening, as judged by the physician * body mass index (bmi) between 18.0-27.0 kg/m2 (both inclusive) exclusion criteria: * the receipt of any investigational products for coagulation factor protein within 6 months prior to trial start (screening) * known or suspected allergy to yeast * known bleeding or hematologic disorder * significant history of alcoholism or drug/chemical abuse as judged by the physician or positive result in the alcohol breath test/screen of drugs at the trial start (screening) * smoking more than 10 cigarettes/day or equivalent * not able or willing to refrain from smoking whenever required for the trial procedures * habitual excessive consumption of methylxanthine-containing beverages and foods (coffee, tea, soft drinks such as cola, chocolate) as judged by the physician * excessive consumption of a diet deviating from a normal diet as judged by the physician * strenuous exercise as judged by the physician within 4 days prior to trial start (screening) * surgery or trauma with significant blood loss (500 ml or more blood) within 3 months prior to trial start (screening) * males who are sexually active and not surgically sterilised, who or whose partner are not using adequate contraceptive methods. adequate contraceptive measures include that the subject uses a condom during intercourse or that the partner practices adequate conception (sterilisation, hormonal intrauterine devices and oral contraceptives).