Kornimate/medical-research-clean huggingface dataset:
rehabilitation device for hand mirror therapy

Conditions: Stroke

Summary: this study is a randomized and open comparative study that uses two parallel groups: a control group training with conventional therapy and another group that trains with the device "miraπ". the participants are patients with stroke with motor weakness in one hand. two measurement visits are required. during those visits, different hand function assessments will be carried out to analyze the motor function of the subjects hand. the measurements will be done during their inpatient rehabilitation stay, one at time of admission and the second at discharge, each taking 20 minutes. in the time between the measurement visits, the hand therapy takes place fivemtimes a week.

the investigators hypothesize that the physical mt with miraπ with physical movement of the affected hand will be generating a better patient outcome than conventional mt. until now mt is performed in front of a mirror with the help of an occupational therapist, which can prove to be difficult. the affected hand of the patient is not moved during training. for the reasons mentioned, the mirror therapy device miraπ was developed. with miraπ, no mirror is needed and the affected hand is also physically moved by the device. therefore, this clinical trial will focus on evaluating the device to see if it works better than conventional mt and therefore creates greater benefits to the patients.

Eligibility criteria:
inclusion criteria: * participants currently accepted and cleared for rehabilitation in the inpatient rehabilitation unit by the rehabilitation medical director. * participants with paralysis or motor function problems of only one hand. * participants spasticity of the affected hand ( as assessed by by the occupational therapist) * participants need mirror therapy because of their health condition. * participants are able to memorize easy tasks, and able to follow instructions e.g., moving the healthy fingers. exclusion criteria: * participants who are not cleared physically or medically to participate in standard acute inpatient rehabilitation therapies by the rehabilitation medical director * participants who are not able to memorize easy tasks, e.g., moving the healthy fingers. * participants with spasticity of the affected hand ( as assed by the occupational therapist) * vulnerable populations
attentionnal performance of shift health workers in emergency department

Conditions: Work-Related Condition

Summary: atypical working hours can be a risk factor for workers. in fact, the body is subject to a circadian rhythm, which affects numerous physiological activities. these biological rhythms reflect the need for certain physiological activities to occur at a specific time of day. this cycle can be disrupted and shifted by external factors. this disruption of biological rhythms can manifest itself in the appearance of health effects. the innovative nature of our work lies in the search for an alteration in psychomotor functions in nursing staff (subject to atypical working hours). to this end, we decided to study the concentration of care workers using a reflex-based psychomotor test, the psychomotor vigilance test (pvt). other factors will be studied in order to assess the factors that may affect this test.

population : all care staff in the emergency departments of the participating hospitals: physicians, residents, nurses and nursing assistants. the main objective is to evaluate concentration in medical/non-medical staff at the start and end of a work shift. to this end, we will evaluate the psychomotor vigilance test (pvt) and its variation at the start and end of a shift in these personnel. the endpoint is the difference in reflex time to a visual stimulus performed at the beginning and end of the shift with a 3-minute pvt test. the first secondary objective is to analyze the number of pvt errors. the criterion defining an error is a reaction time greater than 500ms. the second secondary objective is to compare the pvt and its variation in certain subgroups. the subgroups compared will be defined according to the following criteria : * shift duration: non-medical staff (\ 10h), medical staff (6 to 10h, 10 to 15h, 15 to 24h) staggered shift: start before 6h or end after 22h, * type of service: acute care, mco, ssr (or emergency sector) * sleep quality (pittsburgh sleep quality index), * professional fatigue (maslach burnout lnventory), * anxiety (french official version of the pss-14), * chronotype (morningness-eveningness questionnaire).

Eligibility criteria:
inclusion criteria: * physicians, * residents, * nurses, * nursing assistants exclusion criteria: * students, * paramedics

Keywords: shift-work pvt health worker attentionnal performance emergency department
difference in the estimation of prognosis

Conditions: Malignant Neoplasms of Independent (Primary) Multiple Sites

Summary: objectives: primary objective: the primary objective is to identify the difference in the estimation of prognosis of advanced cancer patients between medical oncologists, gynecological oncologists, and palliative care physicians

the goal of this research study is to identify the difference in the estimation of prognosis of advanced cancer patients between medical or gynecological oncologists, and palliative care physicians. up to 140 patients will be enrolled in this study.

Eligibility criteria:
inclusion criteria: 1. medical oncologists or gynecological who referred patients to the palliative care team; palliative care physicians to whom the patients were referred; patients with locally advanced, metastatic, or, not curable cancer. 2. 18 years old or older exclusion criteria: n/a

Keywords: malignant neoplasms of independent (primary) multiple sites medical oncologists palliative care physicians questionnaire survey
par-101/opt-80 versus vancomycin for the treatment of clostridium difficile-associated diarrhea (cdad)

Conditions: Clostridium Infections; Diarrhea

Summary: this is a comparative study to investigate the safety and efficacy of par-101/opt-80 (fidaxomicin) versus vancomycin in subjects with clostridium difficile-associated diarrhea (cdad).

the primary objective of this pivotal study is to investigate the safety and efficacy of par-101/opt-80 versus vancomycin in subjects with clostridium difficile-associated diarrhea (cdad). the cure rates at end of therapy and recurrence rates will be evaluated and compared.

Eligibility criteria:
inclusion criteria: * males/females with cdad * females must use adequate contraception * signed informed consent exclusion criteria: * life-threatening cdad * toxic megacolon * pregnant * concurrent use of diarrheal agents * participation in other trials

Keywords: cdad, clostridium difficile, diarrhea clostridium difficile-associated diarrhea
aciclovir versus placebo for hsv-2 meningitis

Conditions: Herpes Simplex 2; Meningitis, Viral

Summary: to determine whether active treatment with (val)acyclovir is superior for treatment of viral meningitis compared with placebo assessed by numbers meeting a primary, objective endpoint at 7 days after randomisation


Eligibility criteria:
inclusion criteria: * adults ≥18 years of age admitted on suspicion of viral meningitis defined as: 1. a clinical presentation consistent with viral meningitis (e.g. headache, nuchal rigidity, photophobia, or fever) and 2. cerebrospinal fluid (csf) pleocytosis (\>4 leukocytes x 106/l) and 3. hsv-2 positive by pcr of the csf 4. glasgow coma scale score of 15 and 5. ability to absorb oral medications exclusion criteria: * patients fulfilling any of the following criteria will be excluded: 1. encephalitis as defined by the international encephalitis consortium if diagnosed during standard care (see glossary)20 2. transverse myelitis as defined by the transverse myelitis consortium working group if diagnosed during standard care (see glossary)21 3. severe immuno-compromise defined as an ongoing need for biological- or chemotherapy (e.g. natalizumab), prednisolone \>20 mg/day for ≥14 days, uncontrolled hiv/aids (see glossary), haematological malignancies, and organ transplant recipients14,18,22 4. moderate to severe concomitant genital herpes requiring systemic aciclovir 5. pregnancy (proven by positive urine or plasma human chorionic gonadotropin test in fertile women) 6. hepatic impairment (aspartate aminotransferase or alanine aminotransferase levels \>5 times the upper limit of normal) 7. impaired renal function (estimated glomerular filtration rate \<25 ml/min) 8. intolerance to (val)aciclovir 9. probenecid treatment 10. systemic antiviral therapy with an antiherpetic effect for \>24 hours 11. previous enrolment into this trial

Keywords: meningitis hsv-2 herpes simplex 2 viral meningitis aseptic meningitis acyclovir valacyclovir aciclovir valaciclovir
an outcomes study comparing the intralase fs 60 to the intralase ifs when performing lasik surgery for nearsightedness

Conditions: Myopia; Astigmatism

Summary: the purpose of the study is to compare the results of lasik surgery when using two versions of a femtosecond laser in patients with nearsightedness with and without astigmatism.

the patients will have a comprehensive eye examination once they express an interest in the study. this includes a slit lamp examination of the front of the eye and a dilated fundoscopic examination of the back of the eye. if there is any pathology noted that would exclude the patient from the study, then we will inform the patient and make an appropriate referral. if the patient is deemed appropriate for the study after a comprehensive examination included computerized videokeratography, then they can be enrolled. the patient will undergo bilateral simultaneous eye surgery. which eye is treated with the intralase fs 60 and which eye is treated with intralase ifs will be randomized so there is a 50% chance for either eye to receive one treatment. the patients will be seen on the day of surgery, post op day one, one month, three months, six months and one year. the patient will receive topical antibiotics in each eye for one week following the procedure. the patient will receive pred forte 1% ophthalmic drops for one week after treatment. the patient will also receive vigamox ophthalmic drops for four days after treatment. all of this is within the usual and customary standard of care for the treatment of patients undergoing lasik surgery.

Eligibility criteria:
inclusion criteria: * subjects age 21 and older with healthy eyes. * nearsightedness between -0.25 diopters and -7.00 diopters with or without astigmatism of up to 3.00 diopters. exclusion criteria: * subjects under the age of 21. * patients with excessively thin corneas. * patients with topographic evidence of keratoconus. * patients with ectactic eye disorders. * patients with autoimmune diseases.

Keywords: femtosecond laser fs60 ifs intralase wavefront-guided lasik intralasik lasik myopia nearsightedness
gingival wetness and gingival crevicular fluid volume in patients with dry mouth

Conditions: Xerostomia; Sjogren's Syndrome

Summary: the investigators questioned whether patients with dry mouth complaints display any reduction in residual saliva coating the gingiva and other selected mucosal surfaces. we further intended to test the hypothesis that gingival crevicular fluid volume in patients with dry mouth could be different from that of control subjects. correlations between gingival/mucosal wetness; and unstimulated whole salivary flow rate or minor salivary gland secretion rates and the correlations between clinical periodontal status and salivary measures were also attempted.


Eligibility criteria:
inclusion criteria: * for test group dry mouth complaints and with a diagnosis ofsjogren's syndrome exclusion criteria: * other medical problems that effect salivary glands

Keywords: saliva sjögren's syndrome gcf oral mucosal wetness
evaluation of the effectiveness of patient therapeutic education on chronic insomnia

Conditions: Sleep Initiation and Maintenance Disorders

Summary: 20 to 30% of the general population suffers from chronic insomnia. cognitive behavioral therapy (cbt) is the first-line treatment, but unfortunately its implementation is complex. long waiting times for a consultation / exploration, too short a consultation period, non-reimbursement of specialists and a lack of trained staff make the current care of insomniac patients difficult. patients are thus treated late, often with heavy drug treatment, dependence on sleeping pills, difficult withdrawal and / or reactive mood disorders. the treatment is therefore limited to advice on sleep hygiene and a restriction of time spent in bed without ultimately intervening in the cognitive domain. therapeutic education consists of empowering the patient in the management of chronic insomnia through group education workshops. the patient learns the principles of normal sleep, the way in which sleep evolves with aging, the dangers of treatments as well as the rules of sleep hygiene and the behaviors to modify to sleep well. in addition to benefiting from sharing of experience with other patients, therapeutic education makes the care pathway smoother and considerably reduces the long waiting times of the traditional care pathway in consultation. the study investigators hypothesize that therapeutic education is more effective as a treatment for chronic insomnia than traditional management in individualized consultation (ic). thus, therapeutic education could constitute an effective alternative to cbt.


Eligibility criteria:
inclusion criteria: * the patient must have given their free and informed consent * the patient must be a member or beneficiary of a health insurance plan * patient must understand and read french * patient with icsd-3 diagnostic criteria for chronic insomnia: isi score \> 14/28. exclusion criteria: * patient with cognitive impairment as assessed by the investigator * patient with shift work * patients scoring \> 10/24 on the epworth sleepiness scale * patient suffering from medical or psychiatric illnesses which may, in the opinion of the investigator, compromise the subject's state of health or ability to participate in the study. * patient with chronic alcohol consumption or drug abuse * patient unable to express consent. * pregnant, parturient or breastfeeding patient. * the subject is participating in a category 1 interventional study, or is in a period of exclusion determined by a previous study * it is impossible to give the subject informed information * the patient is under safeguard of justice or state guardianship
screening scottish swimmers for asthma and rhinitis

Conditions: Asthma; Rhinitis

Summary: the scottish national and district swimming teams will be screened for asthma and rhinitis using both mannitol challenge and sport-based exercise challenge.


Eligibility criteria:
inclusion criteria: * member of the scottish national and district swimming team * informed consent obtained exclusion criteria: * pregnant, lactating or planning to become pregnant * concomitant use of medicines (prescribed, over-the-counter or herbal) that may interfere with the trial. * any clinically significant medical condition, as deemed by the clinical investigators, which may endanger the health of the participant or jeopardise the protocol. * inability to comply with the protocol.

Keywords: asthma rhinitis swimmers mannitol
treatment of patients with neck pain after a commuting accident

Conditions: Cervical Injury Spine

Summary: introduction. neck pain is one of the main causes of incapacity for work. the economic impact of neck pain is considerable due to the cost of medical treatment and physiotherapy. accidents in itinere, those that occur on the way between home and the workplace, can cause pain and functional impairment. objective. to analyze the relationship between the time off work following accidents on the way to and from work and the type of treatment received. material and method. multicenter retrospective cohort study. data will be collected from 146 patients. the primary variable of the study will be the time on sick leave (in days), with the type of intervention received (manual therapy or not) being the dependent variable. the secondary variables, estimated as modifying or confounding, will be the intensity of the pain (visual analog scale), sex, age, occupational cervical strain, type of contract (salaried/self-employed) and the number of physiotherapy sessions received.


Eligibility criteria:
inclusion criteria: * patients of both sexes * persons aged 18 to 65 * patients with a medical diagnosis of neck pain secondary to traffic accidents while commuting * persons without a medical diagnosis of another associated pathology * patients whose accident occurred between 2022 and 2024. exclusion criteria: * patients who have received physiotherapy treatment at another centre during the process * patients who requested voluntary discharge for whatever reason.

Keywords: neck pain physiotherapy accidents in itinere incapacity for work
immunogenicity and safety of quadrivalent influenza vaccine in children aged 6~35 months

Conditions: Influenza, Human

Summary: this study is a multi-center, randomized, double-blind phase iii clinical trial. the purpose of this study is to assess the immunogenicity and safety of the quadrivalent cell culture-derived influenza vaccine compare to the trivalent cell culture-derived influenza vaccine in children aged 6\~35 months.

subjects are randomly assigned in a 2:1 ratio to nbp607-qiv 0.5ml versus nbp607-tiv 0.25ml. to assess the immunogenicity, antibody levels are evaluated by hemagglutination inhibition(hi) assay from sera obtained at pre-vaccination and 28 days post-vaccination. to assess the safety, solicited adverse events for 7 days post-vaccination and unsolicited adverse events for 28 days post-vaccination are assessed and reported. the serious adverse events are collected during 6 months post-vaccination.

Eligibility criteria:
inclusion criteria: * children aged 6 months to 35 months * those who was born after normal pregnancy period(37 weeks) for aged 6 months to \< 1 year * those whose legally acceptable representative have given written consent to participate in the study and comply with all study requirements. exclusion criteria: * subjects with immune deficiency disorder or malignant cancer. * history of any hypersensitivity following administration of vaccine or guillain-barre syndrome. * thrombocytopenia or bleeding disorder contraindicating intramuscular vaccination. * subjects who experienced fever within 72 hours before vaccination or with the febrile disease(exceeding 38.0℃) on screening day. * subjects who had received immunosuppressant or immune-modifying drug within 3 months before screening. * subjects who had received blood products or immunoglobulin within 3 months before screening. * subjects who had received influenza vaccination within 6 months prior to the screening. * subjects who had received other vaccination within a month before screening, or those who had another vaccination scheduled within a month after study vaccination. * subjects who had received any other investigational products within 4 weeks prior to study vaccination. * subjects with clinically significant chronic disease. * any other condition which, in the opinion of the investigator, prevents the subject from participating in the study.

Keywords: influenza vaccines vaccines, inactivated cell culture-derived
implant healing abutment and chlorhexidine

Conditions: Periimplantitis

Summary: the work hyposesis is based on the application of a chlorhexidine gel against the non-application on the healing abutments in patients who have received a submerged titanium implant to check its effect on healing and prevention of bacterial plaque accumulation during a period of 1 month.

once the implants are integrated, and given the consent, the patients will be operated to connect the healing abutments as they come from the manufacturer (mozo grau, ticare®). patients will follow the study protocol in 2 arms. the random distribution is made prior to assignment following the internet program https://www.random.org

Eligibility criteria:
inclusion criteria: * good systemic health status (asa i or ii). * no current pain. * no use of painkillers or anti-inflammatory drugs in the prior weeks. * older than 18 years. * oral hygiene index of ≤ 2 (löe and silness). * a minimum of 2 mm of adhered gum. * a minimum of 8 mm of vertical bone. * a minimum of 7 mm of vestibule-lingual bone. * scheduled to receive a unitary implant. * willing to participate in this controlled study. exclusion criteria: * pregnant or nursing women. * use of any type of medication that might affect the perception of pain. * an history of alcohol or drug abuse. * a requirement for guided regeneration or sinus lifting procedures. * failure to comply with the study protocol.

Keywords: chlorhexidine, dental implant, in-situ drug delivery,
bioequivalency study of balsalazide capsules under fasting conditions

Conditions: Ulcerative Colitis

Summary: the objective of this study was to assess bioequivalence of a potential generic 750 mg balsalazide disodium capsule formulation compared with salix pharmaceutical's 750 mg balsalazide disodium capsule, colazal, following a single 750 mg dose, under fasting conditions.


Eligibility criteria:
inclusion criteria: * no clinically significant finding on the physical examination, medical history, or clinical laboratory results during screening. exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enyzme altering drugs. * history of allergic or adverse response to balsalazide, mesalamine, salicylates, or other related drugs.
eswt as a treatment for chronic nho in tbi patients

Conditions: TBI Traumatic Brain Injury

Summary: effect of extracorporeal shock wave therapy on chronic neurogenic heterotopic ossification in traumatic brain injured (tbi) patients chronic neurogenic heterotopic ossification (nho) - heterotopic ossification is a well known late complication of traumatic brain injury. extracorporeal shock wave therapy - eswt- is used in various medical situations and is being tested for feasibility of use in tbi patients.

protocol synopsis title effect of extracorporeal shock wave therapy on chronic neurogenic heterotopic ossification in traumatic brain injured (tbi) patients. the investigators primary objective is to determine whether extracorporeal shock wave therapy (eswt) is effective in reducing pain and improving function in people with traumatic brain injury who have heterotopic ossification around the hip or knee. the investigators hypothesize that four applications of eswt to the affected hip or knee joint in the patient group will demonstrate a positive physiological effect and this will lead to a reduction in pain and improved function.

Eligibility criteria:
inclusion criteria: * age \> 18 years * brain injured patients with a diagnosis of nho around the hip and/ or knee for a period of greater than one year. * patients who are able, or legal guardians who are willing, to provide informed consent after both oral and written information. exclusion criteria: * pregnancy. * rheumatoid arthritis, ankylosing spondylitis, or femoral neck fractures * elevated serum alkaline phosphatase (sap) levels and/or evidence of active bone remodelling in bone scan

Keywords: tbi traumatic brain injury ho heterotopic ossification nho neurogenic heterotopic ossification eswt extracorporeal shock wave therapy