Kornimate/medical-research-clean huggingface dataset:
evaluation of the signaling path of emiline1-tgfβ in the myogenic tone of resistance arteries in a population of normotensive and hypertensive subjects

Conditions: Hypertension

Summary: aim of this study is to enhance the knowledge of myogenic tone alterations in hypertensive patients and to better understand the mechanisms controlling the myogenic tone. evaluations will be performed through ex vivo studies of peripheral arterioles in human adipose tissue from lumbar muscle, isolated from biopsies. this will allow investigators to evaluate the myogenic function in response to progressive blood pressure increases, in order to correlate myogenic function to arterial hypertension and to the molecular mechanisms already identified in the preclinical models.


Eligibility criteria:
inclusion criteria: * males or females between 30 and 70 years of age * hypertensive patients: patients with a previous diagnosis of hypertension * normotensive patients: subjects without story of hypertension * written informed consent exclusion criteria: * severe hypertension (eg, systolic \>180 mm hg, diastolic \>110 mm hg) * manifested or suspected secondary hypertension (coarctation of the aorta, hyperaldosteronism, unilateral or bilateral renal artery stenosis, pheochromocytoma) * history of cardiac complications (previous acute myocardial infarction (ami), unstabile angina, percutaneous transluminal coronary angioplasty (ptca), coronary artery bypass grafting (cabg), congestive heart failure (nyha ii-iv)) * diabetes mellitus * renal pathologies (creatinine clearance \< 30 ml/min) * severe hepatic dysfunction

Keywords: hypertension myogenic tone
study of imiquimod cream prior to ablative therapy in external ano-genital warts

Conditions: Genital Warts

Summary: the purpose of this study is to compare the recurrence rate following total clearance of external genital warts (egws) when clearance has been obtained by imiquimod (3 applications per week for 4 weeks) followed by ablative therapy (laser or electrocautery therapy) with that from just ablative therapy treatment alone.

to compare the recurrence rate 24 weeks after ablative therapy in subjects with external genital warts trated with imiquimod, 3 applications per week for 4 weeks followed by ablative therapy versus vehicle, 3 applications per week for 4 weeks followed by ablative therapy. a recurrence is defined as the investoigator-assessed occurrence of lesion(s) within the baseline area cleared by the treatment: imiquimod/vehicle then ablative therapy (either the initial ablative therápy session (a0), or if required for complete clearance of baseline lesions, a second ablative therapy session (a2).

Eligibility criteria:
inclusion criteria: * subjects with at least 1 visible genital or perianal wart * total wart area 1 to 40 square centimeters. exclusion criteria: * pregnant or lactating women * known other sexually transmitted disease * evidence of a clinically significant immunodeficiency * evidence of unstable cardiovascular, pulmonary, hematological, hepatic, renal, endocrine, collagen vascular, neurological or gastrointestinal abnormality or disease. * treatment within the 4 weeks prior to the randomization visit with any of the following systemic or topical treatments: interferons, interferon inducers, immunomodulators, immunosuppressive drugs, antiviral drugs (except for systemic acyclovir, valacyclovir and famciclovir), cytotoxic drugs, investigational drugs, or any drugs known to have major organ toxicity.

Keywords: external ano-genital warts ablative therapy aldara
shared decision-making for determining treatment strategies in low-risk thyroid cancer

Conditions: Thyroid Cancer; Papillary Thyroid Carcinoma

Summary: this study is a multicenter cluster-randomized controlled trial conducted in korea. a parallel, two-group cluster-randomized design will be used to test whether the shared decision-making group (sdm; intervention) is different from the standard care group (sc; control).

the primary objective of this clinical trial is to evaluate whether the group provided with a decision support tool for treatment planning (intervention; sdm group) demonstrates improved satisfaction with the decision-making process compared to the group receiving standard care (control; sc group) among patients diagnosed with low-risk thyroid cancer who need to determine their treatment plan. the data are collected from patients who are diagnosed with low-risk ptc and twenty doctors with various experience of as will participate in the study.

Eligibility criteria:
inclusion criteria: * adults aged 18 years or older with a thyroid nodule of 1.0 cm or less confirmed as bethesda category v (suspicious for ptc) or vi (ptc) based on cytopathological examination, or bethesda category iii (atypia of undetermined significance) with a confirmed braf v600e mutation. * patients with no evidence of distant metastasis, cervical lymph node metastasis, recurrent laryngeal nerve invasion, or tracheal invasion. additionally, no evidence of extrathyroidal extension (ete) should be present, and the tumor must not belong to high-risk subtypes of ptc (e.g., diffuse sclerosing, columnar cell, or solid subtype). exclusion criteria: * patients who cannot undergo regular follow-up or are expected to have difficulties with follow-up. * patients with indeterminate or benign findings on thyroid biopsy.

Keywords: active surveillance shared decision making
bipolar cohort neunkirchen, final statement

Conditions: Bipolar Disorder

Summary: monitoring system and data base for long term follow up of various treatment strategies in a naturalistic setting of recurrent affective disorders (unipolar, bipolar) open study design, prospective \& retrospective

all hospitalized patients of a defined mixed urban and more rural area were consecutively interviewed at admission and entered into the data base. at discharge they gave written informed consent for further tracking and interviews.

Eligibility criteria:
inclusion criteria: * bipolar exclusion criteria: * all other diagnoses

Keywords: bipolar disorder, naturalistic cohort study, defined catchment area,long term treatment
creatine for the treatment of amyotrophic lateral sclerosis

Conditions: Amyotrophic Lateral Sclerosis

Summary: creatine is a naturally occurring chemical involved in the production of energy in muscle. abnormalities in creatine have been linked to the progression of degenerative neuromuscular diseases such as amyotrophic lateral sclerosis (als, or lou gehrig's disease). this study will test whether taking creatine can improve the symptoms of als.

amyotrophic lateral sclerosis is a progressive neurodegenerative disorder selectively affecting motor neurons, resulting in progressive weakness. currently there is no known cure and a specific cause has not been identified. creatine is a nutritional supplement that improves mitochondrial function and has been shown to protect motor neurons in animal models of als. preliminary research indicates that creatine may also improve strength in patients with als. this study will determine the effect of creatine treatment on short-term muscle strength and long-term muscle deterioration in patients with als. participants in this study will be randomly assigned to receive either creatine or placebo. participants will be enrolled in the study for 9 months. quantitative muscle testing will be done weekly for the first 3 weeks; participants will then be followed monthly for the next 4 months and bimonthly for the remainder of the 9-month study. the study will also monitor purposeful exercise to determine if this enhances the benefit of creatine usage on muscle strength. pulmonary function testing will accompany the muscle testing to determine if creatine strengthens respiratory muscles, thereby enhancing pulmonary function.

Eligibility criteria:
inclusion criteria * diagnosis of probable or definite als * at least 5 of 10 testable upper extremity muscle groups (shoulder and elbow extensors/flexors and grip) of medical research council (mrc) grade 4 or better * at least 5 years from onset of symptoms exclusion criteria * requires tracheostomy ventilation * history of renal disease

Keywords: als creatine
the clinical efficacy of belting stabilization for shoulder pain

Conditions: Rotator Cuff Impingement Syndrome

Summary: application of a belt for stabilization while exercising accelerate and optimize recovery in patients diagnosed with shoulder impingement syndrome.

stabilization through belts is commonly used as an adjunct for treatment of musculoskeletal problems. although this treatment is popular among clinicians, there is a paucity of evidence on its use for shoulder pathology. the objective of this double-blinded longitudinal randomized controlled trial (rct) is to determine the clinical efficacy of stabilization belting applied to patients receiving rehabilitation treatment for shoulder impingement syndrome. the study population will include patients who have been referred to the physiotherapy department of the holland orthopaedic \& arthritic centre for conservative treatment. patients will be randomized into the treatment and control groups. the primary outcome measure is the quick disabilities of arm, shoulder and hand (quickdash) questionnaire.

Eligibility criteria:
inclusion criteria: * diagnosis of impingement syndrome or post-surgical stiffness with an abnormal scapulothoracic rhythm exclusion criteria: * inability to speak or read english * evidence of major joint trauma causing fracture * infection * underlying metabolic or inflammatory disease * avascular necrosis * frozen shoulder * major medical illness * psychiatric illness that precluded informed consent
internal versus external tocodynamometry and labor outcome

Conditions: Dystocia; Contractions

Summary: in this study, parturients will be randomized to either internal or external tocodynamometry contractions' follow up. investigators recruit primiparous, those who try to have vaginal birth after cesarean section and multiparous, who need oxytocin during labor. primary endpoint is the number of operative labors in each group. secondary endpoints are the duration of labor, the use of oxytocin and the condition of the newborn.


Eligibility criteria:
inclusion criteria: * gestational age ≥ 37 weeks * singleton pregnancy * a fetus in cephalic position * normal cardiotocograph in the time of randomization * cervical ripening \< 7 cm * either 1) primipara, 2) multipara, who needs oxytocin during first stage of labor or 3) parturients with previous cesarean section exclusion criteria: * parturient with hepatitis or hiv or other significant viral infection * acute infections (fever over 37,5, or c-reactive protein over 20) in the time of randomization * estimated fetal weight over 4,5 kg * suspected fetal abnormality

Keywords: internal tocodynamometry, external tocodynamometry, cesarean section, labor, newborn, vacuum extraction, dystocia
paravertebral block for pain management after appendectomy

Conditions: Reduce Pain After Appendectomy

Summary: paravertebral block (pvb) was shown to be a successful and useful technique of anesthesia and analgesia. its effect was evident in thoracic and abdominal surgeries. in the setting of appendectomy, somatic pvb has been used for pediatric patients. it was shown to decrease opioid consumption and provide prolonged pain relief. hence, it would be beneficial to examine the analgesic effect of pvb on appendectomy in adult patients.

patients undergoing appendectomy will be randomly allocated into two equal groups using the sealed envelope technique. all patients will receive general anesthesia (ga). patients in group i will receive two pvb injections at levels t12-l1 and l1-l2 using anesthetic mixture, while patients in group ii will receive placebo. paravertebral block technique unilateral right side nerve stimulator-guided pvb is performed while patients are in the left lateral decubitis position. the appropriate levels for the pvb are determined by palpation of the spinous processes. an intervertebral line is drawn at the appropriate levels and the injection site is marked 2.5 cm lateral to the midline. after aseptic preparation of the skin, 1 ml 1% lidocaine is infiltrated at the injection sites. a 21-g nerve stimulation needle (stimuplex; b. braun, melsungen, germany) is advanced 1-2 cm perpendicularly to the skin using a nerve stimulating current of 2.5-5.0 ma, while closely watching for contractions of the abdominal muscles. the tip of the needle is adjusted to maintain muscle contractions while reducing the stimulating current to approximately 0.5-0.6 ma. 4 ml of the local anaesthetic mixture is injected at each injection site. each 20 ml of the local anaesthetic mixture contains: 8ml lidocaine 2%, 8 ml lidocaine 2% with epinephrine 5µg/ml and 4 ml bupivacaine 0.5%.

Eligibility criteria:
inclusion criteria: * older than 18 years * scheduled to undergo appendectomy exclusion criteria: * cardiac disease, * developmental delay, * neurologic deficit, * allergies to any of the drugs routinely used in anesthesia management.
effects of three warm-up interventions at the workplace among vineyard workers - a protocol study

Conditions: Pain; Injuries

Summary: background: physical activity programs at the workplace have shown positive results on physical capacities and pain for several years. due to the duration of the training session, the need of instructor, and the need of a place to practice, these programs are commonly complex to implement. for this reason, many of companies, especially companies in manual sectors are turning to another solution, i.e warm-up intervention before work shift. these interventions present on paper numerous advantages such as short duration, no need to specifically allocate a place in companies and the possibility to perform exercises in working clothes... surprisingly, while positive effects of warm-up interventions on pain, performance physical and psychological capacities, are expansively reported in sport context, effects of workplace warm-up intervention are lacking. therefore, the aims of this study are (1) to implement such intervention among vineyard-workers, workers highly exposed to heavy physical workload and pain and (2) to assess their effects on physical (pain, strength, flexibility) and psychological (workload) functions and also on work-related outcomes (work performance, readiness to work) methods: a cluster randomized study will be implemented among french vineyard workers. four groups of 30 participants will be constituted; corresponding to four different conditions: (1) hybrid warm-up intervention (hwu); (2) dynamic warm-up intervention (dwu); (3) stretching warm-up intervention (swu); (4) no warm-up intervention (nwu). a total of 120 vineyard-workers will be recruited to participate in the study. discussion: the results will provide more evidence about the short-term effects of warm-up interventions at the workplace, and will provide more evidence on which warm-up modality is the most effective on pain, performance, physical and psychological capacities among vineyard workers.


Eligibility criteria:
inclusion criteria: * working full time * having at least 1 year of employment in the company exclusion criteria: - not to present previous surgery in the low back region in the last 12 months

Keywords: pain / injuries / warm-up intervention / vineyard workers / physical activity
an intelligent instrument for improved leg length and hip offset accuracy in total hip arthroplasty

Conditions: Hip Osteoarthritis; Leg Length Discrepancy; Dislocation

Summary: leg length discrepancies following total hip arthroplasty have been associated with nerve palsies, gait abnormalities, and lower back pain. leg length discrepancies are related to poorer functional outcomes and patient dissatisfaction. failure to restore femoral offset following total hip arthroplasty has been linked to decreased range of motion and abductor muscle strength, impingement, limping, higher dislocation rates, increased polyethylene wear, and loosening of implants. computer navigation has shown to improve the accuracy of leg length and hip offset during total hip arthroplasty. the investigators research objective is to prove the accuracy of the intellijoint hip™ system for determining leg length and hip offset. the investigators hypothesis was that intellijoint hip™, an imageless intraoperative intelligent instrument, could improve the accuracy of leg length and hip offset during primary total hip arthroplasty. the investigators plan to study this hypothesis in humans by comparing the leg length and hip offset discrepancies produced with intellijoint hip™ to the standard at the investigators institution, which is a pin and outrigger system.


Eligibility criteria:
inclusion criteria: * any patient who is undergoing a primary total hip arthroplasty at mount sinai hospital. exclusion criteria: * pre-operative flexion contracture \>30°, infection, or inability to achieve rigid fixation of instruments intra-operatively.

Keywords: total hip arthroplasty navigation imageless tha computer navigated
vibration response imaging (vri) in patients that are undergoing pulmonary interventional procedure

Conditions: Central Airway Stenosis

Summary: vibration response imaging (vri) technology, provides a radiation-free dynamic image of the lung, by visualizing vibration energy emitted during the respiration cycle (lung sounds). airflow in the lungs during the respiration cycle creates vibrations that propagate through the lung tissue; these vibrations are affected by the structural properties of the lungs and may vary in space, time and frequency. moreover, any structural alteration, such as a bronchial obstruction or space occupying infiltration, is reflected in a corresponding modification of the vibration response. as obstructions that occur in airways alter airflow, the vri may provide additional lung function information prior to treatment for airway obstruction and during follow-up. moreover, the vri may provide the physician immediate evaluation of the improvement of air flow distribution, quantitative and qualitative measurements. furthermore, the vri is a non-invasive, radiation free procedure which is simple and doesn't require the level of patient effort required for lung function test and other evaluation.


Eligibility criteria:
inclusion criteria: * patient is able to read and understand the informed consent form and he/she will sign the informed consent. * male or female in the age range of 18-85 years. * body mass index \>20. * patient presented with airway obstruction and who are designated to undergo intervention exclusion criteria: * chest wall deformity; * spine deformity (including severe scoliosis or kyphosis); * hirsutism; * potentially contagious skin lesion on the back; * skin lesion that would interfere with sensor placement; * patient is pregnant; * cardiac pacemaker or implantable defibrillator;

Keywords: central airway stenosis, lung sounds, airway obstruction, bronchial obstruction, bronchoscopic treatment
hxlpe vs cpe cups under 50 years

Conditions: Osteoarthritis, Hip

Summary: this randomized controlled trial evaluated the long-term wear of cemented highly cross-linked polyethylene (hxlpe) versus conventional polyethylene (cpe) acetabular cups in patients under 50 years undergoing primary total hip arthroplasty (tha). all surgeries were performed at radboud university medical center by three surgeons using a posterolateral approach. acetabular components included either highly cross-linked polyethylene (hxlpe) cups (x3 rimfit) or conventional polyethylene (cpe) cups (exeter contemporary flanged). both were implanted with bone cement, and femoral components consisted of exeter v40 stems with 28 mm cobalt-chromium heads. impaction bone grafting (ibg) was routinely used, with mesh applied in cases of acetabular bone defects. radiographs were taken preoperatively and at 10-year follow-up using standardized protocols. polyethylene wear was assessed with polyware software, creating 3d models from baseline and 10-year radiographs to calculate linear and volumetric wear. cup inclination and osteolysis were evaluated in three acetabular zones (delee and charnley classification).


Eligibility criteria:
inclusion criteria: * primary tha * age under 50 years exclusion criteria: * tha due to an oncological condition
to pace or not to pace in sinus node disease

Conditions: Sinus Node Disease

Summary: optimal pacing strategy for patients with snd is still unknown, although several publications in the past years demonstrated a deleterious effect of ventricular pacing. however, pacing has always been apical in these trials, and to which extent this absence of pacing is beneficial for patients with very long pr intervals is still to be found. the aim of this study is to compare ventricular septal pacing to no pacing in patients with snd.


Eligibility criteria:
inclusion criteria: * patients with sinus node disease exclusion criteria: * complete or high degree av block * permanent atrial fibrillation
study to evaluate the efficacy and safety of imsidolimab (anb019) in the treatment of subjects with gpp

Conditions: Generalized Pustular Psoriasis

Summary: this is a phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of imsidolimab compared with placebo in adult subjects with generalized pustular psoriasis (gpp).

this study will also characterize the pharmacokinetic (pk) profile of imsidolimab and explore the immunogenicity of imsidolimab in subjects with gpp.

Eligibility criteria:
inclusion criteria: -subject has a bsa affected with pustules (excluding palms and soles) ≥ 5%, a gpppga score ≥ 3 (moderate severity), and a prs score ≥ 3 (moderate severity) at day 1 exclusion criteria: * subject has other form of psoriasis excluding psoriasis vulgaris * subject flare is so severe that patient's life is at risk

Keywords: il-36 receptor interleukin 36 imsidolimab
development and implementation of electronic decision aids for genetic testing in inherited cancer syndromes

Conditions: Genetic Testing

Summary: an electronic decision aid will be used to assist individuals in choosing a multi-gene panel with their medical oncologist instead of a genetic counselor. a decision aid may facilitate quality decisions around the selection of a specific multi-gene panel without a genetic counselor. upon completion of the decision aid, participants will be asked to indicate their decision about whether to pursue genetic testing and which specific multi-gene panel to pursue. a survey will then be administered to assess participants' opinions on the decision aid.


Eligibility criteria:
inclusion criteria: * adults (18 years of age or older) * diagnosed with malignant ovarian tumor or malignant pancreatic adenocarcinoma exclusion criteria: * children (\<18 years of age) * unable to complete surveys * previous germline genetic testing

Keywords: decision aid