Kornimate/medical-research-clean huggingface dataset:
imatinib mesylate in treating patients with recurrent ewing's family of tumors or desmoplastic small round-cell tumor

Conditions: Sarcoma

Summary: rationale: imatinib mesylate may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth. purpose: this phase ii trial is studying how well imatinib mesylate works in treating patients with recurrent ewing's family of tumors or desmoplastic small round-cell tumor.

objectives: * determine the effectiveness of imatinib mesylate in patients with recurrent ewing's family of tumors or desmoplastic small round-cell tumor. * determine the toxic effects of this drug in these patients. * determine the duration of disease-free and overall survival of patients treated with this drug. outline: this is an open-label study. patients receive oral imatinib mesylate twice daily on days 1-28. courses repeat every 28 days. projected accrual: a total of 20-40 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * diagnosis of ewing's family of tumors or desmoplastic small round-cell tumor * must have immunohistochemical evidence of expression of greater than 2+/4+ for either kit (cd117) or platelet-derived growth factor receptor -a or -b * no symptomatic brain metastases * asymptomatic brain metastases are allowed provided patient is not on concurrent anticonvulsants or corticosteroids patient characteristics: age * over 16 performance status * ecog 0-2 life expectancy * not specified hematopoietic * absolute neutrophil count greater than 1,500/mm\^3 * platelet count greater than 100,000/mm\^3 * hemoglobin greater than 9 g/dl hepatic * bilirubin less than 1.5 times upper limit of normal (uln) * sgot and sgpt less than 2.5 times uln * no chronic active hepatitis * no cirrhosis * no other acute or known chronic liver disease renal * creatinine less than 1.5 times uln cardiovascular * no concurrent poorly controlled or severe cardiovascular disease pulmonary * no concurrent poorly controlled or severe pulmonary disease other * hiv negative * no concurrent poorly controlled or severe central nervous system disease * no other concurrent poorly controlled or severe nonmalignant disease prior concurrent therapy: biologic therapy * not specified chemotherapy * at least 3 weeks since prior chemotherapy endocrine therapy * see disease characteristics radiotherapy * at least 3 weeks since prior radiotherapy surgery * more than 2 weeks since prior major surgery other * more than 28 days since prior investigational agents

Keywords: recurrent ewing sarcoma/peripheral primitive neuroectodermal tumor
remifentanil versus morphine for sedation of premature neonates with respiratory distress syndrome

Conditions: Respiratory Distress Syndrome

Summary: in this randomised controlled study we intended to compared intubation conditions and the continuous infusion of remifentanil (n=10) and morphine (n=10) in mechanically ventilated premature neonates (28-34wk) regarding the time to be awake and, the time until extubation after interruption of the opioid administration.

intubation and mechanical ventilation are majors component of intensive care for premature neonates with respiratory distress syndrome (rds) and is associated with physiologic, biochemical, and clinical responses indicating pain and stress in prematures. although morphine is one of the most used drugs for premedication and for sedation and analgesia during mechanical ventilation in the treatment of rds its pharmacological profile precludes several limitations mostly due to its much delayed onset of action what makes the drug not suitable as premedication and due to its prolonged duration of action mainly in prematures. unlike morphine, remifentanil has an unique pharmacokinetic properties with a rapid onset of action and, a fast decrease in plasma concentration after interruption of administration due to a context-sensitive half-time of 3.2 minutes. so, it could be the ideal opioid for neonates who are especially sensitive to respiratory depression by opioids

Eligibility criteria:
inclusion criteria: * gestational age between 28 and 34 wk * clinical and radiological features compatible with respiratory distress syndrome that required an elective tracheal intubation and surfactant therapy. exclusion criteria: * the presence of major congenital malformations * birth weigh less than 1000g * previous or concurrent use of opioid for any reason (cesarean section with general anaesthesia) * hemodynamic instability before the indication of tracheal intubation * refuse of the parents to enroll the neonate in the study protocol

Keywords: intubation sedation analgesia preterm neonate remifentanil morphine respiratory distress syndrome
use of virtual reality in the treatment of flying phobia

Conditions: Flying Phobia

Summary: the project aims to explore the potential of virtual reality exposure therapy (vret) for the treatment of the fear of driving, the fear of flying and the fear of public speaking. the study is a randomized controlled trial (rct) designed to compare the efficiency of cognitive behavioural therapy with exposures in imagination to behavioural therapy with exposures in virtual reality. anxiety levels are measured using specific questionnaires, sud ratings and physiological measures (heart rate, skin conductance, skin temperature, breathing frequency, heart rate variability). hypothesis: treatments with exposures in virtual reality are more efficient than treatments with exposures in imagination.

in the past, several studies have demonstrated the effectiveness of virtual reality exposure therapy in the treatment of flying phobia and driving phobia. as an objective tool, psychophysiological recordings help demonstrate the decrease of physiological aspects of anxiety reactions (heart rate, skin conductance, skin temperature, heart rate variability and breathing pattern). the aim of the present study is to examine the effects of cognitive behavioural therapy with exposures in imagination to behavioural therapy with exposures in virtual reality in the treatment of patients with flying phobia. thirty patients will be randomized into either an imagination exposure group or a virtual reality exposure group after having received four sessions of cognitive behavioural therapy for coping with panic attacks. respective exposure therapies consist in four sessions. anxiety levels will be measured before and after the cognitive behavioural therapy for coping with panic attacks as well as before and after the exposure therapy sessions and after 3 months using specific questionnaires, sud ratings and psychophysiological measures (heart rate, skin conductance, skin temperature, breathing frequency and heart rate variability). the exposure stimuli will consist in a 10min movie of a flight with an insight-cabin viewing perspective. the investigators hypothesize that virtual reality exposure therapies will be more effective than imagination exposure therapy in terms of decrease of anxiety self-ratings and psychophysiological fear reactions.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of a specific phobia (dsm-iv-tr) exclusion criteria: * pregnant women * subjects with severe pulmonary / cardiovascular problems; asthma, epilepsy, vertigo * drug abuse * subjects under on-stabilized anti-depressant treatment * psychotic subjects * subjects with suicidal ideas * subjects presenting insufficient intellectual capabilities

Keywords: cognitive behavior therapy virtual reality exposure therapy psychophysiological measures driving phobia flying phobia
the usefulness of hyperq recordings for the early diagnosis of acute coronary syndrome in patients presenting with chest pain

Conditions: Acute Coronary Syndrome

Summary: the purpose of the study is to assess the usefulness of high frequency mid-qrs analysis in identifying the ischemic origin of patients presenting to the emergency room (er)with chest pain.

introduction: chest pain is the leading cause of urgent admission to the emergency department (ed) in western countries.acute coronary syndrome(acs) continues to be among the most difficult to predict or diagnose. misdiagnoses may lead to discharge of patients with acs, who should have been admitted as well as costly unnecessary hospitalizations of patients who do not have acs. objectives: to evaluate the usefulness of high frequency mid-qrs analysis in identifying the ischemic patients out of all patients presenting to the emergency room (er) with chest pain. comparisons: a continuous high frequency mid-qrs recording will be performed using the hyperq system (bsp ltd.) and compared to clinical, electrophysiologic and laboratory results. the golden standards used to compare the methods will be either ct-angio, echocardiography or cardiac spect. a follow-up inquiry will be performed after 3 months and coronary angiography results will be sought and compared as well.

Eligibility criteria:
inclusion criteria: * age ≥18 years * patients with chest pain, with possible acs. * patients admitted to the 'chest pain unit' * chest pain appeared within 24 hours prior to admission to the 'chest pain unit' * no history of trauma or any other evident medical cause of chest pain * signed an informed consent exclusion criteria: * implanted pacemaker or defibrillator * history of trauma or other evident medical cause of chest pain * patients admitted to intensive cardiac care unit or intermediate cardiac care unit * patients discharged from the er * patients with bundle-branch-block or other intra-ventricular delay of more than 120 msec

Keywords: acute coronary syndrome hyperq high frequency ecg chest pain
a patient education video program for post-operative recovery after upper extremity surgery

Conditions: Analgesics, Opioid; Orthopedic Surgery; Ambulatory Surgery; Education, Patient; Injuries and Wounds

Summary: adult patients undergoing elective outpatient, upper extremity, orthopedic surgeries will be randomized to view one of two educational programs: 1) a 2-video series regarding post-operative pain management or 2) a video regarding wound care and activity. the effect of this educational program on pain medications used, pain control efficacy, and other measures of satisfaction and recovery will be assessed.

four hundred (400) adult patients undergoing elective outpatient, upper extremity, orthopedic surgeries will be recruited by the surgeon-investigators. patients will be randomized to view one of two educational programs: 1) a 2-video series regarding post-operative pain management or 2) a video regarding wound care and activity. these patients will be encouraged to review the video online in the week before surgery. an intake enrollment form will be completed by an investigator using demographic information available in the chart. participants in both arms will complete their patient education study diary daily, for 7 days following their surgery. there are two versions of this diary: the wound education version asks patients to report daily pain mediation use. the pain education version does not include this section as patients in the pain management arm of the study record this information in their recovery diary. the patient will be contacted again by phone and/or mail 1 year after surgery (12-14 months) using the contact information available in epic to determine the self-reported prevalence of chronic pain and pain medication use.

Eligibility criteria:
inclusion criteria: * adult patients planning elective outpatient orthopedic surgery procedures by a carilion clinic hand surgeon will be eligible for the study. exclusion criteria: 1. patients unable or unwilling to provide informed consent 2. patients unable to unwilling to participate in the trial (poor english language skills, blindness, cognitively disadvantaged, poor literacy skills, other barriers to participation) 3. patients who are or suspect they may be pregnant. 4. patients for whom the medical provider, in his professional judgment, does not feel that the study protocol would be appropriate. (to be tracked)

Keywords: opioid analgesic ambulatory orthopedic surgery patient education video medication diary
yoga for solid tumor

Conditions: Solid Tumor, Adult

Summary: the purpose of this study is to ascertain the effect of yoga interventions on radiation-related fatigue, and stress in cancer patients with stage i and ii solid tumors.


Eligibility criteria:
inclusion criteria: 1. stage i and ii cancer patients with solid tumors undergoing rt for 4-8 weeks (external beam radiation). 2. patients of age \>18, and all races will be included in the study. 3. all patients must sign an informed consent form approved for this purpose by the institutional review board (irb) of the university of pennsylvania. 4. patients must be english speaking. 5. patients must be able to attend the schedule classes. exclusion criteria: 6. patients with medical restrictions that may interfere with or prevent them from taking part in the yoga interventions per their physician orders. 7. patients with metastatic disease. 8. active smokers. smoking may interfere with relaxation and breathing modalities of the yoga interventions. (self-reporting smokers that have been smoke free for 6 months may be included) 9. patients who currently practice or have recently practiced yoga (had not taken a yoga class on a regular bases in the last 6 months).
phonoaudiologic therapy adjunct to treatment on patients with obstructive sleep apnea

Conditions: Obstructive Sleep Apnea Syndrome

Summary: objective: to evaluate the effects of a speech therapy exercises program in the treatment of obstructive sleep apna syndrome (osas) patients based on the clinical and polysomnography (psg) parameters. methods: 80 patients with osas will be evaluated: men, 25-65 years old, body mass index \ 9. patients will be divided into four groups: i: 20 patients with osas underwent speech therapy; ii: 20 patients with osas underwent placebo therapy of speech therapy; iii: 20 patients starting treatment with cpap underwent speech therapy; iv: 20 patients starting treatment with cpap without speech therapy or placebo. the speech therapy include isometric and isotonic exercises to improve posture, mobility and muscle tone of the soft palate, pharyngeal constrictor muscles, tip and base of tongue, cheeks and lips. placebo therapy includes relaxation exercises and stretching neck, without therapeutic purpose. both therapies are applied for three months, three times a day, lasting 20 minutes each session. during the treatment, the subjects will be monitored in weekly meetings, for orientation and description of the exercises and return of the fulfilled exercises diary. the subjects will also be followed at the cpap clinic in returns after one week, a month and at the end of the study. conduct assessments before and after treatment and after twenty one days washout, including: assessing the upper airway, anthropometric investigation of the facial skeleton and speech of orofacial, questionnaires (epworth sleepiness scale, fosq, general segment and use of cpap, whoqol-bref, snoring), psychomotor vigilance test and psg.


Eligibility criteria:
inclusion criteria: * patients with a recent diagnosis of osas * body mass index (bmi) \< 35 kg/m2 exclusion criteria: * facial malformations * regular use of hypnotic medications * hypothyroidism * previous stroke * neuromuscular disease * heart failure * coronary disease * severe obstructive nasal disease

Keywords: obstructive sleep apnea oropharyngeal exercises speech therapy
continuous regional analysis device for neonate lung

Conditions: Infant Respiratory Distress Syndrome; Acute Bronchiolitis; Acute Respiratory Distress Syndrome

Summary: the purpose of the study is to assess whether electrical impedance tomography (eit) has the potential to optimize the ventilator therapy, validate the effectiveness, efficacy and safety of nursing and medical interventions (endotracheal suctioning, posture changes, surfactant therapy, recruitment manoeuvres, etc.) and for early recognition of complications like pneumothorax and endotracheal tube misplacement. the study design is purely observational.

eit data will be recorded during 72 hours of routine clinical treatment. to prevent any decisions based on eit information, the clinicians will be blinded to the eit findings during the study period. data on clinical interventions and clinical findings will be recorded using a specially adapted graphical user interface on the eit device in combination with a paper-based case report form (crf). eit data analysis will be performed off-line.

Eligibility criteria:
inclusion criteria: * written, informed consent of both parents or legal representative * admission in the nicu or picu * patients with or at high risk of developing respiratory failure needing respiratory support. o i.e. (oxygen need (fio2\>25%) and noninvasive or invasive respiratory support) and/or repeated apnea with desaturations * age from birth to 7 years o initial focus will be on neonates up to 6 kg and 12 months age. infants of higher weight up to 7 years age will be included as eit belts for this age group become available. exclusion criteria: * post menstrual age less than 25 weeks * body weight \< 600 g * electrically active implants * thorax skin lesions * prior participation for the same diagnosis of lung disease
supplemental oxygen and the risk of surgical site infection

Conditions: Surgical Site Infection

Summary: this is a study to see whether increasing the oxygen concentration during and after a cesarean section decreases the infection rate.

this is a double-blinded prospective randomized,controlled trial to evaluate whether using a higher concentration of oxygen during and after surgery helps to decrease the wound infection rate in patients undergoing cesarean sections.

Eligibility criteria:
inclusion criteria: * mentally competent patients undergoing cesarean section under spinal or epidural anesthesia exclusion criteria: * fever/chorioamnionitis; gbs positive on antibiotics; immunocompromised / hiv patients; on antibiotics for any reason; general anesthesia; age less than 18 years custody patients stat cesarean section

Keywords: wound infection
natural progression of high-risk chronic limb-threatening ischemia: the clariti study

Conditions: Critical Limb Ischemia; Peripheral Artery Disease

Summary: the objective of this observational registry is to track the clinical progression of chronic limb-threatening ischemia (clti) and incidence of death, amputation, and revascularization attempts over a one-year period.

the objective of this observational registry is to track the clinical progression of chronic limb-threatening ischemia (clti) and incidence of death, amputation, and revascularization attempts over a one-year period. the study population is comprised of rutherford 5 and 6 clti subjects who have hemodynamic evidence of severely diminished arterial inflow of a peripheral limb and: 1. 2 revascularizations in the last 6 months that failed to resolve symptoms, or 2. have inadequate popliteal, tibial, or pedal revascularization target

Eligibility criteria:
inclusion criteria: 1. subject must be ≥18 years of age 2. subject is rutherford 5 or 6 classification with hemodynamic evidence of severely diminished arterial inflow of a peripheral limb and: a) 2 revascularizations in the last 6 months that failed to resolve symptoms, or b) an inadequate popliteal, tibial, or pedal revascularization target 3. subject is willing and able to sign the informed consent form and willing to participate in the phone follow-ups. exclusion criteria: 1. any significant concurrent psychological or social condition (e.g., no support person/network), which may significantly interfere with the subject's optimal participation in the study, in the opinion of the investigator. 2. subject is participating in the promise ii clinical trial.

Keywords: cli
phase i pharmacokinetic study (bf-block)

Conditions: Asthma

Summary: the objective of the study is to assess if charcoal prevents the absorption of budesonide and formoterol via gi track. the assessment will be based on comparing the pharmacokinetic parameter area under the concentration-time curve.


Eligibility criteria:
inclusion criteria: 1. healthy males and females aged 18-60 years. 2. normal weight at least 50 kg. exclusion criteria: 1. evidence of a clinically significant cardiovascular, renal, hepatic, haematological, gastrointestinal, pulmonary, metabolic-endocrine, neurological or psychiatric disease. 2. any clinically significant abnormal laboratory value or physical finding that may interfere with the interpretation of study results or constitute a health risk for the subject if he/she takes part in the study. 3. any condition requiring concomitant treatment (including vitamins and herbal products) or likely to need any concomitant treatment during the study. 4. known hypersensitivity to the active substance(s) or the excipients of the drug. 5. pregnant or lactating females.

Keywords: asthma
near infrared transillumination of the paranasal sinuses

Conditions: Sinusitis

Summary: this research project designed to diagnose sinusitis using a simple and low-cost optical tool. healthy sinuses are typically filled with air, and show up as bright spots on the camera. infected sinuses are filled with fluid and show up dark spots on the camera. images of infected sinuses could be used to diagnose sinusitis, or to check if surgical treatments on the sinuses have been successful.

this device consists of a specialized flashlight that uses mostly non-visible light, and a small camera to record the light. the tool is the size and shape of spoon. the technique of shining light into the mouth, face, and sinuses is known as "transillumination" and has been used for nearly a century to aid in the diagnosis of sinusitis. the tool described in this study is a custom made device that uses light that is invisible to the eye.

Eligibility criteria:
inclusion criteria: * male and female age of 15 years or older. * has diagnose of sinusitis, nasal allergies,nasal breathing problem, and tumors. exclusion criteria: * age less than 15 year sold

Keywords: sinusitis