Kornimate/medical-research-clean huggingface dataset:
biopsychosocial outcomes of mindfulness-based instruction

Conditions: Specific Learning Disability; Mental Health Issue

Summary: over 20% of adolescents living in the united states have a diagnosable psychiatric disorder. however, most adolescents who need mental health services do not receive them due to many reasons, including low resources in families and communities, stigma, lack of mental health providers, and other barriers to mental health care access. alabama currently ranks 50th in access to mental healthcare and 51st (last) in mental healthcare provider availability with only one mental healthcare provider for every 920 persons in need. most adolescents attend school, so delivering mental health services in the school setting eliminates many barriers to mental health care access. from the point of prevention, participation in universal social and emotional learning (sel) programs within the school setting improves social and emotional skills, behaviors, attitudes, and academic performance. mindfulness-based instruction is a promising approach to sel for improving psychological functioning that is evidence-based, widely available, and scalable to various populations and settings. this project aims to investigate whether a sel program that incorporates mindfulness-based instruction (mindup) leads to improvements in not only self-reported well-being (i.e., anxiety, mindful attention, perceived stress, and positive and negative affect), but also objectively measured executive functioning, academic achievement, and regulation of stress physiology. the investigators will partner with schools that serve historically underserved students to test the effectiveness of the mindup program in 5th and 6th graders. this study has the potential to benefit underserved students and their teachers who will receive training on sustainable implementation of the mindup curriculum.


Eligibility criteria:
inclusion criteria: * fifth grade students at i3 academy * fifth and sixth grade students at tarrant intermediate school * 6th through 8th grade students at spring valley school * all students enrolled in general education will be invited to participate in the study exclusion criteria: * those with medical, developmental, or psychiatric conditions that compromise their ability to provide valid self-reports or complete other study procedures * only one child per family will be allowed to participate to avoid dependency in data due to clustering within families

Keywords: mindfulness-based-intervention social and emotional learning anxiety stress affect executive function academic achievement
the response to atropine drops (rad) study

Conditions: Myopia

Summary: the purpose of this study is to examine the comfort of giving low concentration atropine eye drops.

after being informed about the study and potential risks, all participants giving written informed consent will answer questions about themselves and complete a 12-question survey about the need for drama. an examiner will then measure the sensitivity of the cornea (clear window on the front of the eye) by touching the cornea with a thin thread that shortens until it is first detected by the participant. after that, an examiner will place a drop of atropine in the right eye, and the participant will rate the eye comfort for 25 seconds using a computerized slide scale. five minutes after the first drop, the examiner will put a drop in the left eye and the participant will rate the comfort for 25 seconds. the examiner will then repeat that process one more time with each eye. the drops placed in the eyes will be 0.01% atropine at room temperature from lab a, 0.05% atropine at room temperature from lab a, 0.05% atropine refrigerated from lab a, or 0.05% atropine at room temperature from lab b. the drops will be placed in the eyes in random order, so the participant won't know which one is being administered. at the very end, the participant will rate how likely s/he would be to take a low concentration atropine eye drop every day in each eye if it may delay the onset of nearsightedness from 1 (definitely not) to 10 (definitely would).

Eligibility criteria:
inclusion criteria: * 18 years and older exclusion criteria: * none

Keywords: atropine
clinical significance of collagen metabolism changes in left cardiac ventricle

Conditions: Aortic Stenosis

Summary: as there are no clinical data in cardiology about the relationship between metabolism collagen changes and their clinical significance, the investigators will check the hypothesis that collagen metabolism changes, detected by biochemical markers for collagen metabolism, could predict the left ventricle remodelling and prognosis in patient with clinically significant pressure overloaded left ventricle.

clinical assessment and endpoints: 1st day (the day of entering the hospital or the day of the first contact): informed consent (see below), clinical examination, ecg, complete echocardiography evaluating the function of the left ventricle (ef) and the presence and the significance of valvular disease, basic laboratory tests incl. ckmb, troponin i, taking of blood samples (5 ml) for the detection of collagen metabolism markers serum level, x-ray of chest, 2nd-3rd day: clinical examination, ecg, basic laboratory tests incl.ckmb, troponin i (only group i) 4th day: clinical check up, ecg, echocardiography, taking of blood samples (5ml) for the detection of collagen metabolism markers serum level (only group i) 30th day: clinical examination l, ecg, echocardiography, taking of blood samples (5ml) for the detection of collagen metabolism markers serum level, 24 hrs ecg monitoring (holter) 6 months: clinical examination, ecg, echocardiography, taking of blood samples (5ml) for the detection of collagen metabolism markers serum level, holter monitoring 1 year: history, clinical examination primary endpoint: combined clinical endpoint: death/repeated hospitalisation due to heart failure/myocardial infarction within 30 days and during 1 year follow up. secondary endpoints: rehospitalisation for cardiovascular reason, clinically significant arrhythmias, correlations between left ventricle parameters evaluated by echocardiography and collagen metabolism changes evaluated by serum markers

Eligibility criteria:
inclusion criteria: 1. isolated severe aortic stenosis (index aortic valve area less than 0,5 cm2/m2 or mean transaortic pressure gradient more than 40 mm hg, assessed by echocardiography) and left ventricular hypertrophy (see above) 2. signed informed consent exclusion criteria: 1. presence of more than mild aortic regurgitation or other significant valvular lesion 2. impossibility to obtain echocardiographic tracing of good quality 3. all other diseases, which significantly influence collagen metabolism (renal failure, insulin dependent diabetes mellitus, bone diseases, hepatic failure)

Keywords: ventricular hypertrophy collagen aortic stenosis
optimization of postoperative bowel habits

Conditions: Constipation

Summary: project is a trial, in which women undergoing vaginal surgery for pelvic organ prolapse will be randomized 1:1 to a postoperative bowel regimen of either oral senna or rectal bisacodyl suppository.

delayed return to bowel function following vaginal surgery for pelvic organ prolapse has been deemed to be highly distressing for patients, and is ranked as one of the most common reasons for emergency department visits and telephone calls in the immediate post-operative period. despite the prevalence of constipation and significant effect on quality of life, few studies have examined an evidence-based bowel regimen for postoperative constipation prevention in the urogynecology population. as per available medical literature, the onset of action for oral senna occurs within 6-12 hours, while bisacodyl suppository can take effect between 15 and 60 minutes following rectal administration. proposed trial comparing oral senna to rectal bisacodyl suppositories for the prevention of postoperative constipation in women undergoing vaginal reconstructive surgery for symptomatic prolapse.

Eligibility criteria:
inclusion criteria: * women ages 18 and older scheduled to undergo vaginal pelvic organ prolapse repair exclusion criteria: * women younger than 18 years old * those unable to provide consent * preexisting chronic laxative use * conditions that could affect bowel function including, inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, rectovaginal fistula; concurrent bowel surgery; intraoperative bowel injury

Keywords: bowel habits pelvic surgery laxatives
efficacy and safety study of ingavirin® to treat influenza and acute respiratory viral infections in children 7-12 y.o.

Conditions: Influenza, Human; Acute Respiratory Infection; Viral Infection; Common Cold

Summary: the purpose of this study is to determine whether ingavirin ® dosed 60 mg daily is effective and safe in the treatment of influenza and other acute respiratory viral infections in 7-12 years old patients.


Eligibility criteria:
inclusion criteria: * the informed consent form signed by the patient's parent/adoptive parent to participate in the clinical study * male and female patients aged 7-12 * patients with moderate course of influenza or other acute respiratory viral infections (avri) * patients with clinically diagnosed influenza or other arvi based on the body temperature \> 37,5 ° c, not less than 1 of the following other symptoms of intoxication and not less than 1 of the following of catarrhal symptoms: * intoxication symptoms: headache, malaise, myalgia, pain in the eyeballs; * catarrhal symptoms: sore throat, rhinorrhea, cough, nasal congestion * uncomplicated course of influenza and other arvi * interval between onset of symptoms and enrollment to the study of not more than 36 hours exclusion criteria: * complicated course of influenza and other acute respiratory viral infections * treatment with antiviral drugs (antivirals, interferons and interferon inducers), drugs with immunomodulatory effects or antibiotics with systemic and local action within 7 days prior to the screening visit * severe influenza or other arvi with symptoms of cardiovascular disease, and other symptoms of infectious-toxic shock, and meningoencephalitic syndromes * signs of primary viral pneumonia development (presence of two or more of the following symptoms): shortness of breath, chest pain when coughing, systemic cyanosis, dullness of percussion sound at symmetrical assessment of the upper and lower parts of the lungs * infectious diseases within the last week prior to enrollment * "rri children" (incidence of arvi within the last 12 months is 6 times or more) * asthma history * history of increased seizure activity * severe decompensated or unstable medical or psychiatric conditions (any diseases or conditions that threaten the life of the patient or worsen the patient's prognosis and also make it impossible to conduct a clinical study in the patient). * cancer, hiv infection, tuberculosis, including those in history * hypersensitivity to imidazolyl ethanamide pentandioic acid and/or excipients of ingavirin product * diabetes, lactose intolerance, lactase deficiency, glucose-galactose malabsorption, deficiency of sucrase/isomaltase, fructose intolerance, hereditary glucose malabsorption, deficiency of glucose-6-phosphate dehydrogenase * participation of the patient in any other clinical trial within the last 90 days prior to enrollment
quantitative diagnosis of liver fibrosis on multiparametric mri

Conditions: Liver Fibrosis; Cirrhosis

Summary: early diagnosis and treatment of liver fibrosis can repress or delay the development of cirrhosis and hepatocellular carcinoma. the purpose of this pilot study is to evaluate non-invasive multiparametric magnetic resonance imaging (mri) techniques in the detection and grading of liver fibrosis, so that patients can be treated in time. these techniques combined could reach high diagnostic performance for detection of liver fibrosis, and could decrease the number of liver biopsies.

early diagnosis and treatment of liver fibrosis can repress or delay the development of cirrhosis and hepatocellular carcinoma. while liver biopsy is still considered the gold standard for diagnosing and assessing the presence and degree of liver fibrosis and inflammation, it has disadvantages including the potential for sampling error and risk of complications. new imaging modalities such as diffusion weighted imaging (dwi), intravoxel incoherent motion (ivim), diffusion kurtosis imaging (dki), t1ρ relaxation time (t1ρ), t1 mapping of pre-contrast and hepatocyte phase using hepatocyte specific agent and susceptibility weighted imaging (swi) allow non-invasive evaluation of liver parenchymal characteristics and may be able to detect and quantify parenchymal fibrosis alleviating the need for biopsy. patients with chronic liver disease or normal liver parenchyma who are scheduled to undergo either liver resection or liver biopsy are included. referred patients undergo multiparametric mri including dwi, ivim, dki, t1ρ, t1 mapping of pre-contrast and hepatocyte phase and swi before surgery or biopsy. the pathologic changes are evaluated using multiparametric mri, and compared between normal/early fibrosis and advanced fibrosis. to explore if combine these techniques could reach higher diagnostic performance for detection and grading of liver fibrosis. this project will provide a reliable and noninvasive method for the monitoring stage of liver fibrosis and therapeutic evaluation.

Eligibility criteria:
inclusion criteria: * chronic liver disease (viral hepatitis, alcoholic hepatitis, or other...) * and willingly able to complete all research procedures and follow the entire research process * and scheduled for liver resection or biopsy * and signed informed consent exclusion criteria: * any contraindication for contrast-enhanced mri * pregnant or nursing women * any organ transplant history, and existing functional grafts (except corneal or fur grafts) * recent right upper quadrant patients with traumatic healed * a serious history of illness or other evidence of a serious illness or suffering from any other disease * patients who have been enrolled in other interventional clinical trials

Keywords: liver fibrosis, multiparametric magnetic resonance imaging
intra-operative trans-rectal ultrasound guidance for robot-assisted radical prostatectomy

Conditions: Prostate Cancer

Summary: radical prostatectomy, or the surgical extirpation of the prostate, is a standard treatment for prostate cancer. the state of the art radical prostatectomy involves a robotic laparoscopic surgery system (the da vinci) which provides the surgeon with excellent 3d visualization of the surgical site and improved dexterity over standard laparoscopic instruments. while the long term prognosis of prostate cancer patients who undergo radical prostatectomy has improved significantly over the past two decades, there remain significant rates of disease recurrence and complications. the investigators hypothesis is that advanced trans-rectal ultrasound (trus) imaging can be deployed and used easily during surgery, can be registered to the robot coordinate systems with high accuracy, and can be controlled from the surgeon's console, in order to improve the visualization of the prostate and peri-prostatic anatomy, and in order to produce a cancer probability map that can be used to make decisions on surgical margins. the investigators objectives are 1. to demonstrate that trus imaging can be integrated with the da vinci radical prostatectomy 2. to determine the ability of trus imaging to intra-operatively visualize the prostate and peri-prostatic tissue from the surgical console this is an observational study; trans-rectal ultrasound will be used to visualize the prostate and periprostatic structures during surgery but the standard of care will not be affected by this ultrasound imaging.


Eligibility criteria:
inclusion criteria: * all men who undergo robot-assisted radical prostatectomy are eligible. exclusion criteria: * none

Keywords: surgery robotic ultrasound guidance endorectal
double-blind comparison of combined general-spinal anesthesia to general anesthesia for coronary artery surgery

Conditions: Coronary Artery Disease; Coronary Artery Bypass Surgery

Summary: use of neuraxial agents in anesthesia for cardiac surgery is expanding. we have used combined general-spinal anesthesia for cardiac surgery for 12 years. we hypothesized that compared to general anesthesia, the combined techniques would provide comparable intraoperative hemodynamics and improved postoperative analgesia. this study subjected these techniques to a double-blind randomized trial.

use of neuraxial agents in anesthesia for cardiac surgery is expanding. we have used combined general-spinal anesthesia for cardiac surgery for 12 years. we performed a trial in order to determine if our clinical impressions of the techniques would be confirmed. we hypothesized that compared to general anesthesia, the combined techniques would provide comparable intraoperative hemodynamics and improved postoperative analgesia. this study subjected these techniques to a double-blind randomized trial. methods after irb approval, 63 consenting patients undergoing non-emergent coronary artery bypass grafting (cabg) entered a randomized, double-blind trial. patients received lorazepam 0.03 mg/kg preoperatively, and midazolam 0.03 mg/kg during line insertion and induction. spinal procedures, performed by an unblinded study anesthesiologist, preceded general anesthesia, which was induced with propofol and rocuronium, and maintained with isoflurane through cpb, and propofol thereafter. all caregivers were blinded to group assignment. opioid and spinal management defined 3 groups: ga: sufentanil iv: 3 μg/kg induction, 1 μg/kg x 2 prn; mock spinal so: sufentanil iv: 0.2 μg/kg induction, 0.1 μg/kg x 2 prn; spinal: sufentanil 50 μg, morphine 0.5 mg, hyperbaric sl: sufentanil iv: 0.2 μg/kg induction, 0.1 μg/kg x 2 prn; spinal: sufentanil 25 μg, morphine 0.5 mg, bupivacaine 9.75 mg, hyperbaric when patients were stable in icu, propofol was stopped and an extubation protocol begun. patients received scheduled nsaid and prn opioid, iv or po. the chi-square test and anova using the scheffe method for multiple comparisons were applied appropriately. the primary end points of the study were analgesic requirements, visual analogue pain scores, and duration of endotracheal intubation in the intensive care unit. secondary endpoints were intraoperative hemodynamic variables, blood catecholamine and lactate levels, anesthetic supplementation, and vasoactive drug support.

Eligibility criteria:
inclusion criteria: * patients undergoing non-emergent primary coronary artery bypass grafting using cardiopulmonary bypass exclusion criteria: * \ 80 years of age * left ventricular ejection fraction \< 35% * receiving inotropic or intraaortic balloon therapy at time of surgery * receiving intravenous heparin therapy at time of surgery * pre-existing back problems in the lumbar area * clinical or laboratory evidence of coagulopathy

Keywords: coronary artery bypass surgery anesthesia, general anesthesia, spinal heart-lung machine
evaluation of the pi-rads v2.1 score using multiple readers

Conditions: Prostate Cancer; Urological Cancer

Summary: the interpretation of prostate multiparametric mri (mpmri) is difficult and requires expertise. as a result, it suffers from substantial inter-reader variability. the so-called prostate imaging reporting and data system (pi-rads) scoring system has been launched in 2012 to try and standardise prostate mpmri interpretation. it is a 5-level score that assesses the likelihood that suspicious focal prostatic lesions seen on mpmri are clinically significant prostate cancers. despite the use of semi-objective criteria for each category of the score, the inter-reader reproducibility of the first two versions (pi-rads v1 launched in 2012 and pi-rads v2 launched in 2015) was moderate at best, even for experienced readers. the last version (pi-rads v2.1) has been launched in march 2019 in an effort to improve the inter-reader reproducibility. this version has not been evaluated yet. the purpose of our study is to evaluate the accuracy and inter-reader reproducibility of the pi-rads v2.1 score on a large set of 171 prostate mris using 21 readers of varying experience. twenty-one readers (14 seniors and 7 juniors) from 9 different institutions and with varying experience in prostate mpmri accepted to participate to the study. reader will assess the dataset independently and will be blinded to the other readers' results. they also be blinded to clinical and biochemical data.


Eligibility criteria:
inclusion criteria: * prostate mpmri and biopsy performed at our institution * performed between september 2015 and july 2016 * no history of prostate cancer at the time of the mpmri exclusion criteria: * patients who already had treatment for prostate cancer * patients under active surveillance

Keywords: multiparametric mri isup prostate cancer
impact of individualized music listening for people with dementia on anxiety: a quasi-experimental study

Conditions: Music Listening

Summary: this pilot study was designed to evaluate the effects of individualized music listening (iml) implemented on older adults with mild cognitive impairment (mci) and pwd. this quasi-experimental study used convenience sampling where thirty-two elderly individuals were recruited from five community-based dementia care centers then assigned to experimental (eg, n = 16) or control (cg, n = 16) groups according to the self-reports of importance of music in their lives and according to their personal wishes. the eg received eight treatments of iml (two times per week, 20 minutes per time), while the cg received the usual activities of the care centers for four weeks when eg received iml. the anxiety levels of both groups were investigated before and after first time iml and after eighth time iml. the researcher observed positive and negative behaviors of eg before, during and after each iml per 20 minutes in each time iml.


Eligibility criteria:
inclusion criteria: 1. 50 years or older; 2. mild cognitive impairment or dementia. exclusion criteria: 1. can not answer questions by themselves; 2. have the habit of listening music in the past week.

Keywords: dementia individualized music listening anxiety behavior