Kornimate/medical-research-clean huggingface dataset:
coordination training with complete body video games in children and adults with degenerative ataxias

Conditions: Spinocerebellar Ataxia

Summary: exergame training might offer a novel treatment approach even in largely nonambulatory subjects with multisystemic degenerative spinocerebellar ataxia.

effective treatments for patients with degenerative spinocerebellar ataxia are scarce. it has recently been shown that intensive coordinative training based on either physiotherapy or exergames (= whole-body controlled videogames; might improve degenerative ataxia, but its effectiveness is still disputed. this situation is even more complicated for degenerative ataxia subjects in advanced disease stages and with high multisystemic disease load. here, underlying neurodegeneration has progressed to many irreversible states and includes many additional extra-cerebellar systems, making functional plasticity and therapeutic success much less likely. moreover, intervention outcome assessment in subjects unable to walk freely is more delicate. correspondingly, nonambulatory ataxia subjects in advanced disease stages are currently often excluded from treatment trials, thus leaving them without prospects of access to novel treatments. the investigators here hypothesized that exergame training might offer a novel treatment approach even in largely nonambulatory subjects with multisystemic degenerative spinocerebellar ataxia. using a rater-blinded, intraindividual control study design, the investigators show that an individualized exergame training strategy, tailored to individuals' disease stage, improves postural control and ataxia-specific control functions even in advanced disease.

Eligibility criteria:
inclusion criteria: * advanced spinocerebellar disease * advanced impairments in gait and stance, defined as scale for assessment and rating of ataxia (sara) subscore gait ≥3 and stance ≥3, but still able to sit without support \>10 seconds, as defined by sara subscore sitting \<3 * age between 5 and 30 years exclusion criteria: * any signs of inflammatory, vascular, malformation, or tumor cerebrospinal (cns) disease * visual loss, hearing disturbances, mental retardation and predominant non-ataxia movement disorders (e.g. predominant spasticity, chorea, parkinsonism)

Keywords: exergaming neurodegenerative diseases rare disease motor exercises training spinocerebellar ataxia
reliability, validity, and responsiveness of the turkish version of eating assessment tool-10 for patients with primer sjögren's syndrome

Conditions: Sjogren's Syndrome

Summary: evaluations will be made by researchers following the guidance of individuals with primary sjögren's syndrome who receive diagnosis, routine medical care, and treatment management. in addition, for the reliability of the turkish eating assessment tool-10, the turkish eating assessment tool-10 will be repeated on patients at least one-fifth of the number of individuals included, after one week. for the sensitivity of the scale, an exercise that is routinely applied in the rheumatological rehabilitation unit of hacettepe university faculty of physical therapy and rehabilitation will be invited and after 3 months, the same evaluations as applied in the first measurement will be made again on individuals at least one-fifth of the number of individuals included.


Eligibility criteria:
inclusion criteria: * patients diagnosed with primary sjögren's syndrome * 18 years or older exclusion criteria: * patients with secondary sjögren's syndrome, * patients who are diagnosed with other uncontrolled/clinically important diseases (chronic obstructive pulmonary disease, congestive heart failure, endocrine system diseases, neurological, psychological diseases, etc.), * individuals who do not agree to participate in the study and do not give written consent will be excluded from the study.

Keywords: primer sjogren's syndrome swallowing disorder
acetabular fractures of both columns

Conditions: Acetabular Fractures; Both Columns

Summary: the purpose of this research is to study a specific acetabular (hip socket) fracture pattern and how its treatment affects the functional, clinical, and x-ray outcomes. there are no experimental procedures involved.

this study will identify a small subset of patients that fall outside the letournel classification system of acetabular fractures. the fracture pattern, its influence on the surgical treatment decision making process, and the radiographic and outcomes will be detailed. in particular, both-column acetabular fractures with significant posterior deformity have been correlated with poor functional outcomes, increased arthritis radiographically, and worse prognosis in general. despite these findings, there has been no specific study evaluating these injury patterns to date. we present ten patients with both column acetabular fractures and an associated posterior column/wall piece and their clinical outcomes in an effort to help guide surgical treatment and offer prognostic guidance.

Eligibility criteria:
inclusion criteria: * all patients that underwent surgical fixation of the hip at hershey medical center between june 2006 and may 2007 by dr's j. spence reid and david goodspeed. * they will include patients that are admitted directly from the field or are transferred from outside hospitals. exclusion criteria: * will be those acetabular fractures of non-traumatic etiology (e.g.: secondary to malignancy or fatigue) * fractures that have not undergone operative fixation * pediatric populations under the age of 18 * mentally compromised patients * those that do not give consent for the clinical evaluation.

Keywords: acetabular fractures
a study comparing the efficacy and safety of lidocaine 5% patch with placebo in patients with chronic axial low back pain

Conditions: Chronic Low Back Pain

Summary: patients with chronic axial low back pain participated in a phase ii clinical trial to assess the efficacy of lidocaine 5% patch compared with placebo.


Eligibility criteria:
key inclusion criteria: * had axial lbp with or without radiation present for at least 3 months as defined as: * chronic axial lbp without radiation: pain isolated to the axial low back without radiation into the buttock or below * chronic axial lbp with radiation: pain that radiates to the buttock or below. this patient group could include patients with radicular/neuropathic and non-radicular components with leg pain component \<50% * had daily moderate to severe lbp as the primary source of pain * had a normal neurological examination, including: * motor strength * sensory exam in lower extremities * deep tendon reflexes * had a normal 12-lead electrocardiogram (ecg) without any clinically significant abnormalities in heart rate, rhythm, or conduction * had discontinued use of all analgesic medications (including over-the-counter \[otc\] analgesics) prior to randomization (patients were allowed limited use of analgesic medications for indications other than non-study pain). * had a daily average pain intensity rating of 6 or greater (on a 0 to 10 scale) for at least 3 days out of the 5 consecutive days immediately prior to the baseline visit; 0 was defined as "no pain" and 10 was defined as "pain as bad as ever imagined" as measured by question 5 of the brief pain inventory (bpi) and recorded in a diary key exclusion criteria: * had spinal stenosis with \> 50% leg pain component * had elective surgery scheduled to occur during the 14-week study * had a history of one or more back surgeries within 1 year of study entry * had severe renal insufficiency (creatinine clearance of \<30ml/min) * had moderate or greater hepatic impairment * were taking analgesic medications that could not be discontinued during the study. patients taking these medications prior to the study were required to discontinue use for the duration of the study. patients using opioid analgesics at study entry were required to taper off these medications. * were taking long-acting opioids or opioids that could not be discontinued over the first 5 days of the placebo run-in period * had received an epidural steroid/local anesthesia injection within 4 weeks prior to study entry * had received trigger point injections within 2 weeks prior to study entry * had received botulinum toxin (botox) injections for lbp within 6 months prior to study entry * were using a lidocaine-containing product that could not be discontinued during the study * were using any topical medication applied to the low back region * had previously failed treatment with lidoderm analgesic patch for lbp * were taking class 1 anti-arrhythmic drugs (e.g. mexiletine, tocainide) * had any other chronic pain condition that, in the opinion of the investigator, would have interfered with patient assessment of lbp relief
drug use investigation for revolade (itp)

Conditions: Purpura, Thrombocytopaenic, Idiopathic

Summary: to investigate safety and efficacy in the actual use of revolade collected from all subjects receiving the drug until data from a specified number of subjects are accumulated to identify factors considered to influence its safety and efficacy. \ thromboembolism


Eligibility criteria:
inclusion criteria: * subjects with chronic idiopathic thrombocytopenic purpura exclusion criteria: * not applicable
interdisciplinary collaborative care model combined with family empowerment in comorbid hypertension and diabetes

Conditions: Hypertension; Diabetes; Blood Pressure Control; Glucose Control; Psychosocial Adaptation

Summary: the iinterdisciplinary collaborative care model combined with family empowerment (iccm-fe) intervention based on the com-b model can effectively improve blood pressure and glucose control in patients with comorbid hypertension and diabetes, enhance their quality of life and psychosocial adaptation, and significantly increase patient satisfaction with nursing care. this intervention has important clinical application value.

to evaluate the efficacy of an interdisciplinary collaborative care model combined with family empowerment (iccm-fe) based on the com-b model in managing comorbid hypertension and diabetes, focusing on its impact on blood pressure, glucose control, and psychosocial adaptation. this prospective randomized controlled trial (rct) enrolled 187 patients with comorbid hypertension and diabetes from january 2023 to march 2024. patients were randomly assigned to a control group (n = 93) receiving routine care and an observation group (n = 94) receiving iccm-fe intervention. follow-up was conducted over 6 months, assessing blood pressure (sbp and dbp), glucose levels (fpg and hba1c), quality of life (sf-36 scale), psychosocial adaptation (pais-sr scale), and nursing satisfaction (nsns scale) pre- and post-intervention.

Eligibility criteria:
inclusion criteria: * patients met the diagnostic criteria for hypertension and diabetes as specified in the 《2020 international society of hypertension global hypertension practice guidelines》and the 《2020 american diabetes association (ada) standards of medical care in diabetes》 ; * had at least one caregiver, and both the patient and caregiver had basic communication and comprehension abilities to cooperate with the nursing interventions and complete the questionnaires; * voluntarily participated in the study and signed an informed consent form; * complete follow-up records. exclusion criteria: * severe organ dysfunction or mental illness; * malignancies, severe cardiovascular events (e.g., stroke, myocardial infarction); * severe hepatic or renal impairment; * poor adherence or life expectancy less than 1 year.
coping intervention after embryo transfer

Conditions: Anxiety; Depression

Summary: background of the study: undergoing an ivf or icsi treatment is an emotional and physical burden for both the woman and her partner. most stressful for the couple is waiting for the result of the treatment, the period after the embryotransfer until the pregnancy test or menstruation and an unsuccessful treatment. symptoms of anxiety and depression have been identified in couples during the waitingperiod after an embryotransfer. for this waitingperiod a short selfhelp copingintervention has been developed based on the stress theory of lazarus for women to use at home. goal of the instrument is to stimulate the copingstyle positive reappraisal. research has demonstrated that using this copingstyle can have a positive impact in health related circumstances.

objective of the study: to investigate if a short copingintervention reduces anxiety in patients undergoing an ivf or icsi treatment in the umcu during the waitingperiod after an embryotransfer. study design: in this research a randomised controlled trial (rct) will be used for three groups. the choice for three groups has been based on earlier research with a daily record keeping (drk). the drk is a daily measurement for emotions, copingstyle and physical complaints. previous research with the drk showed an increase of anxiety. more research must be done of the impact of the drk. group 1: positive reappraisal coping intervention (prci) \& drk \& questionnaires group 2: drk \& questionnaires group 3: standard care \& questionnaires study population: patients undergoing an ivf or icsi treatment in the umcu. intervention (if applicable): a selfhelp coping intervention primary study parameters/outcome of the study: anxiety secondary study parameters/outcome of the study (if applicable): risk of emotional problems copingstyle depression vital pregnancy quality of life nature and extent of the burden and risks associated with participation, benefit and group relatedness (if applicable): using the coping intervention may reduce anxiety for the patient. the use of this instrument is not a burden for patients. the burden for patients is to complete questionnaires before, during and six weeks after the embryotransfer. partners are asked to fill in a questionnaire at three times.

Eligibility criteria:
inclusion criteria: * patient in ivf/icsi treatment exclusion criteria: * patient who do not speak the dutch language

Keywords: coping intervention waiting-period
cardioprotective effect of acute exercise in breast cancer patients

Conditions: Early-stage Breast Cancer

Summary: cardiotoxicity is one of the most significant adverse effects in breast cancer patients treated with anthracyclines (a type of chemotherapy), so we propose to determine whether acute training (i.e., 24h before each chemotherapy session) could reduce the levels of a cardiac biomarker which measures muscle damage (nt-probnp). given the fact nt-probnp attenuation has been observed with one session performed 24h before the first treatment, we propose to verify these findings in each cycle of doxorubicin analyzing how each type of exercise (aerobic, strength or combined aerobic + strength) may impact on anthracycline-induced cardiotoxicity, since this observation may be relevant considering the feasibility and low cost this implementation would represent in clinical practice.


Eligibility criteria:
inclusion criteria: * woman with non-metastatic breast cancer not previously treated. * scheduled to receive neoadjuvant doxorubicin chemotherapy. * receive the oncologist´s approval for the practice of exercise. * acceptance of randomization. * to sign an informed consent form before starting any measurement or procedure related to the project. exclusion criteria: * patients who receive initial surgery and who are not going to receive neoadjuvant treatment. * contraindications to perform stress tests following the recommendations of the american thoracic society. * pre-existing cardiovascular disease. * body mass index (bmi) \> 35 kg/m2. * diabetes mellitus. * renal disease. * severe anemia. * pregnacy. * current smoking status.

Keywords: breast cancer exercise doxorubicin anthracyclines cardiotoxicity
efficacy and safety of intranasal morphine for pain after bunion surgery

Conditions: Hallux Valgus

Summary: study designed to evaluate the efficacy and safety of intranasal (in) morphine nasal spray (mns075) 3.75 mg, 7.5 mg, 15 mg, and 30 mg, intravenous (iv) morphine 7.5 mg, or in placebo in patients with moderate to severe post-surgical pain following orthopedic surgery. after initial dosing, up to six (6) doses of in mns075 7.5 mg or 15 mg for up to twenty-four (24) hours will be evaluated. the rescue dose remained the same for each.

diagnosis and main criteria for inclusion: healthy adult patients (18 to 76 years old), who scored ps-1 to ps-3 according to the american society of anesthesiologists physical status classification system, requiring primary, unilateral, first metatarsal bunionectomy surgery alone or with ipsilateral hammertoe repair without additional collateral procedures.

Eligibility criteria:
inclusion criteria: * requires primary unilateral first metatarsal bunionectomy surgery alone or with ipsilateral hammertoe repair under regional anesthesia. the patient requires collateral orthopedic surgical procedures other than ipsilateral hammertoe repair may not be enrolled into the study. * 18 years of age or older * moderate to severe pain within eight (8) hours following completion of the required bunionectomy surgery exclusion criteria: * allergy to shellfish * signs of nasal congestion, nasal polyps, mucosal lesions of the nostrils, postnasal drip of any etiology or any clinically significant nasal pathology that may affect the absorption of study medication or the assessment of safety. * chronic respiratory insufficiency such that treatment with an opioid analgesic is contraindicated additional inclusion/exclusion criteria may apply

Keywords: post surgical pain bunionectomy hammer toe syndrome morphine
prospective phase ii trial on prophylactic perihepatic lymphadenectomy in patients with colorectal cancer with liver metastasis

Conditions: Colorectal Cancer With Liver Metastasis

Summary: objective: to evaluate the role of regional lymphadenectomy in patients with colorectal cancer liver metastasis. background: lymph node status is 1 of the most important prognostic factors in oncologic surgery; however, the role of lymph node dissection remains unclear for colorectal cancer liver metastasis.

lymph node status is a definite prognostic factor in oncologic surgery and significantly affects long-term survival, as reported by the tumor staging system of the international union against cancer (iucc), which is the most widespread classification of malignant tumors worldwide. regional lymphadenectomy is already the standard procedure that completes hepatic resection in the case of carcinoma arising from the extrahepatic bile duct. however, the indication, extent, and role of lymph node excision are still a matter of discussion, and no clear guidelines exist in patients with colorectal cancer liver metastasis.

Eligibility criteria:
inclusion criteria: 1. first hepatectomy; 2. age \<75 years; 3. absence of severe cardiovascular,pulmonary, or other associated diseases; 4. absence of other malignant disease; 5. absence of distant metastases secondary to colorectal cancer other than liver metastases (except a solitary peritoneal tumor that could be completely resected during hepatectomy); and 6. complete resection of liver metastases confirmed during surgery. exclusion criteria: 1. hnpcc 2. fap 3. patient who refuses perihepatic lymphadnectomy 4. medical condition in which surgery cannot be tolerated

Keywords: colon neoplasm, rectal neoplasm, liver metastasis
evaluating the haemostatic effect of nnc 0129-0000-1003 during surgical procedures in subjects with haemophilia a.

Conditions: Congenital Bleeding Disorder; Haemophilia A

Summary: this trial is conducted globally. the aim of this trial is to evaluate the haemostatic effect of nnc 0129-0000-1003 during surgical procedures in subjects with haemophilia a.


Eligibility criteria:
inclusion criteria: * informed consent obtained before any trial-related activities. (trial-related activities are any procedure that would not have been performed during normal management of the subject.) * ongoing participation in the pathfinder™2 (nn7088-3859) or the pathfindertm 4 (nn7088-3861) trial and having received greater than or equal to 5 doses of n8-gp * undergoing major surgery requiring daily monitoring of fviii:c (fviii activity) and wound status for at least 3 days * the patient and/or legally acceptable representative (lar) is capable of assessing a bleeding episode, keeping an ediary, capable of home treatment of bleeding episodes and otherwise capable of following the trial procedures exclusion criteria: * known or suspected hypersensitivity to trial product including allergy to hamster protein or related products * previous withdrawal from the pathfinder™2 (nn7088-3859) or the pathfindertm 4 (nn7088-3861) trial after administration of trial product, except interruption due to inclusion in this pathfindertm 3 trial (nn7088-3860) * the receipt of any investigational medicinal product (except n8-gp) within 30 days prior to enrolment into the trial. (for brazil, only: participation in a previous clinical trial within one year prior to screening for this trial (visit 1), unless there is a direct benefit to the research subject, at the investigator's discretion) * fviii inhibitors at least 0.6 bu (bethesda units)/ml at screening * previous arterial thrombotic events (e.g. myocardial infarction and intracranial thrombosis) or previous deep venous thrombosis or pulmonary embolism (as defined by available medical records) * immune modulating or chemotherapeutic medication * any disease (liver, kidney, inflammatory and mental disorders included) or condition which, according to the investigator's judgement, could imply a potential hazard to the patient, interfere with trial participation or trial outcome * unwillingness, language or other barriers precluding adequate understanding and/or cooperation
a comparison of rapid immunoassays for the detection of ruptured membranes

Conditions: Evidence of Ruptured Membranes in Women Greater Than 15 Weekd

Summary: specific objectives include analysis of performance of rom plus® in diagnosing rom, as compared to amnisure® and the conventional clinical assessment confirmed by a thorough chart review after delivery. inclusion criteria: * english speaking * pregnant woman \>15 weeks gestation undergoing an exam for ruptured membranes exclusion criteria: * known placental previa * active vaginal bleeding


Eligibility criteria:
inclusion criteria: * complaint of ruptured membranes * iup \> 15 weeks gestation * english speaking, over the age of 18yrs old exclusion criteria: * active bleeding * placenta previa
risk factors for inadequate bowel preparation in patients with chronic constipation

Conditions: Constipation

Summary: chronic constipation is one of the risk factors of inadequate bowel preparation, which could influence the effect of colonoscopy. the risk factors associated with inadequate bowel preparation in constipated patients remains unclear. here the investigators investigated the high risk factors which might have influence on bowel preparation quality in a prospective cohort of patients with functional constipation.


Eligibility criteria:
inclusion criteria: * 18-90 * patients undergoing colonoscopy; * patients meeting the criteria of chronic constipation of rome ⅳ; exclusion criteria: * history of colorectal surgery; * known of suspected colonic stricture or obstructing tumour; * ulcerative colitis; * crohn's disease; * irritable bowel syndrome; * toxic colitis or megacolon; * known or suspected bowel obstruction or perforation; * pregnancy or lactation; * unable to give informed consent; * haemodynamically unstable.

Keywords: bowel preparation chronic constipation risk factor