Kornimate/medical-research-clean huggingface dataset:
whether probiotics use in neonate and infant improve their mother's life quality

Conditions: Postpartum Depression; Quality of Life; Functional Gastrointestinal Disorders; Probiotics

Summary: postpartum depression and poor quality of life during postpartum were an vital issue in recent years. infant's health condition was thought to be a possible reasons related mother's postpartum quality of life, and functional gastrointestinal disorders such as infantile colic and regurgitation were common problem during infant period. previous study revealed that probiotics may improve the infant's discomfort caused by functional gastrointestinal disorders. thus, this study aimed to investigate whether probiotics use in neonate and infant improve their mother's life quality?

this is single blinded intervention study. the investigators will invite mother to participate in the project after giving birth. at week 0, mother who meet the eligibility criteria will be randomized in a single-blind study in a 1:1 ratio to probiotics with vit. d3 (five drops per day) or vit. d3 (placebo) (single drop per day) for 90 days. the follow-up will be at the 1, 3 and 6 months all the subjects.

Eligibility criteria:
\ inclusion criteria : * gestational age more than 37 to less than 41 weeks * age less than 1 week on entry into the study * birth weight adequate for gestational age * apgar score of more than 8 at 10 minutes exclusion criteria: * congenital disorders and/or clinical or physical alterations at clinical examination * antibiotic or probiotic administration before inclusion * admission to icu \ inclusion criteria: * aged between 20-50 and baby included in our study exclusion criteria: * diagnosed as psychiatric disease during antepartum period or before pregnancy

Keywords: postpartum depression probiotics infantile colic
head and neck cancer screening and serum repository

Conditions: Head and Neck Squamous Cell Cancer

Summary: head and neck squaumous cell cancer(hnscc) is the 6th most common cancer in the united states and the 3rd most common worldwide. risk factors include abuse to tobacco and alcohol. survival is related to stage of hnscc when treatment is sought. most hnscc patients present with advanced staged disease. this screening activity will educate patients with hnscc rick factors and screen for pre malignant and/or early staged lesions.

otolaryngology staff memebers and residents will perform head and neck examinations upon participants after the participant has completed their questionnaire and had the opportunity to partcipate in the research portion by having blood drawn. a suspicious head and neck examination will be considered abnormal, and further recommendations for follow-up will be made. participants will be provided with a list of practicing head and neck surgeons within the state of arkansas.

Eligibility criteria:
inclusion criteria: exclusion criteria: * under the age of 18 years of age
smbg protocols predicting glucose levels in senior diabetes mellitus with cad

Conditions: Diabetes Mellitus, Type 2; Coronary Artery Disease

Summary: self-monitoring of blood glucose (smbg) is a common way to assess glycemic control in diabetes management. multiple times of blood glucose measurements by fingerstick in the same day are of tough challenge to it. the changes and variations of glucose excursion in senior diabetics with coronary artery disease (cad)involve a safety issue besides glycated hemoglobin (ghb) value. the goal of this study is to explore modified smbg protocols for precisely monitoring and predicting glycemic excursion, variability in senior type 2 diabetics with cad.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of type 2 diabetes * clinical diagnosis of coronary artery disease * age ≥65 years * the blood glucose is controlled by diets and (or) oral hypoglycemic drugs * bmi≤28 kg/m² * being able to monitor and record capillary glucose value by themselves at home exclusion criteria: * diabetic ketoacidosis (dka) * acute cardiovascular events * anemia * insulin treatment * incapable to perform smbg at home

Keywords: diabetes mellitus coronary artery disease smbg elderly
stretching with and without pressure biofeeback in patients with postural syndrome

Conditions: Postural; Defect

Summary: postural syndrome describes a variety of conditions in which repetitive or continued bad posture over a long period of time causes pain and reduced function in the muscles and joints. improper posture can cause pain throughout the length of the spine from the neck to the pelvis. modern sedentary style of living is one of the main reasons for postural abnormalities evident in modern society. the prolonged sitting hours required in most of the jobs, and educational setups can affect flexibility of soft tissues, especially two joint muscles. bad posture while standing or walking, if left uncorrected, can worsen over time and lead to pain and dysfunction. hamstring is a key component of flexibility in the human body and it is more prone to get tightened. many reasons can lead to the development of hamstring tightness such as genetic predisposition, injury to muscle, and adaptive shortening due to some chronic condition. short hamstring muscles, because of their attachments to the posterior leg and to the ischial tuberosity, may limit hip flexion rom and induces posterior pelvic tilt and decreased lumbar lordosis, which can result in lbp the purpose of this study will be to find out the effects of stretching with and without pressure biofeedback unit (pbu) on hamstring muscle flexibility in patients with postural syndrome. the active knee extension (ake) test will be used to determine the length of the hamstring muscles using a goniometer. a pbu will be used to maintain the anterior pelvic tilt position during active knee extension (ake) test or stretching, by monitoring the pressure of airbag. patients will be recruited into study by convenient sampling technique after that will be allocated to groups by simple random assignment. all participants will actively stretch three days per week for four weeks. after collecting data from defined study setting, data will be entered and analyzed by using statistical package for the social sciences (spss) for windows software, version 25.


Eligibility criteria:
inclusion criteria: * males and females of aged 18 to 25 years with hamstrings shortening less than 70 degrees are included in the study exclusion criteria: * subjects with any past hamstring injury within last 2 years * low back pain since past 3 months * current or recent (last 3 months) participation in a specific program designed to lengthen the hamstrings are excluded

Keywords: pressure biofeedback unit, stretching hamstring muscles active knee extension test
this study is mainly about finding incidence among other factors of thyroid cancer in patient with benign disease as mng to early discover of the malignancy to save the patient from aggressive procedure

Conditions: Thyroid Cancer

Summary: the purpose of the present study was to evaluate the prevalence of thyroid cancer in patients who had thyroidectomy for mng, and analyze patient-related parameters to identify type and risk factors associated with incidental thyroid malignancy.

multinodular goiter (mng) is a common thyroid disorder characterized by the presence of multiple nodules in the thyroid gland. it is a benign condition, but a proportion of patients with mng have risk of developing thyroid cancer . thyroid carcinoma is one of the most frequent types of endocrinological cancers, and its occurrence has been on the rise globally. total thyroidectomy is regarded as the most effective surgical treatment for mng and is also advised for patients with diagnosed thyroid cancer. several studies have revealed a greater incidence of thyroid cancer in mng. published data regarding the prevalence of thyroid cancer within a multinodular goitre (mng) have demonstrated a wide distribution of cancer rates, ranging from 3 to 35 percent. although fine-needle aspiration (fna) is the most accurate and cost effective method of thyroid nodule evaluation, benign cytological -diagnosis is associated with false-negative. further complicating this topic, fna cytology may be non-diagnostic in up to 25 per cent of patients with nodular thyroid disease, and its performance in the setting of mng presents other difficulties, including deeply located thyroid nodules that may be more challenging to aspirate as well as reliably evaluating all suspicious nodules. incidental thyroid cancer (itc) is sometimes detected in the final pathological examination, the incidence of itc after surgery varies widely in literature, ranging from 2% to 30%. certain risk factors, such as sex, age, history of neck irradiation, family history, calcifications observed during imaging studies, size of the thyroid tumor and thyroid-stimulating hormone (tsh) levels, may be related to itc; however, this remains controversial. although previous studies have focused on clinical factors related to cancer, the knowledge on pathologic characteristics of itc is limited.

Eligibility criteria:
inclusion criteria: * male or female patients with multinodular goiter patients with normal thyroid function tests patients with fnac negative for malignancy patients who are fit for general anesthesia exclusion criteria: * patient suspicious nodule on ultrasound imaging patients in whom distant metastases occurred preoperatively but fnac was negative for malignancy patients with a history of thyroidectomy patients with severe comorbid conditions with high risk for general anesthesia
point-of-care ultrasound in the emergency department evaluation of syncope

Conditions: Syncope

Summary: the purpose of this study is to determine whether point-of-care (bedside) ultrasound assists physicians in the evaluation and management of patients with syncope.

syncope is one of the more common presentations to the emergency department, representing between 1.2-1.5% of all evaluated patients and up to 6% of admissions. due to an often broad and overlapping differential diagnosis, syncope represents a disease entity that often requires extensive workup. this typically involves laboratory tests, ekgs, x-rays, computed tomography, or other studies that are costly, time-consuming, and, in the case of diagnostic imaging, frequently involves ionizing radiation. yet, despite extensive testing, an exact diagnosis is not made in up to 50% of cases. cardiac causes of syncope include myocardial infarction, pericardial effusion, volume depletion, arrhythmia, among other entities, many of which are life threatening. echocardiography (cardiac ultrasound) has been used for inpatient syncope evaluations for several decades. in the emergency department, echocardiography is currently being used at the point-of-care (poc) in a limited and focused approach to a variety of conditions. however, poc ultrasound has never been systematically evaluated as a diagnostic or prognostic tool specifically for syncope in the emergency department. we aim to determine if an ultrasound-based protocol is effective as an adjunct in the evaluation of syncope. our research study will examine the utility of poc ultrasound in the diagnosis, imaging and laboratory utilization, and prognosis of syncope in the emergency department.

Eligibility criteria:
inclusion criteria: * 18 years and older presenting to the ed with acute syncope (defined as transient loss of consciousness) or near syncope (sensation of impending but not actual loss of consciousness) as a reason for ed visit. exclusion criteria: * persistent altered mental status * alcohol or illicit drug-related loss of consciousness * definite seizure, and transient loss of consciousness caused by head trauma.

Keywords: syncope point of care ultrasound echocardiography
randomised prospective study of cusa versus radiofrequency ablation technique in liver resections

Conditions: Liver Disease

Summary: the purpose of this study is to determine whether a particular method of operating on the liver is superior to the "gold" standard commonest technique. cusa (ultrasonic agitation) will be compared to the newer heat coagulation technique (radiofrequency ablation) and comparisons of blood loss, transfusion requirements, complication rates, hospital stay, effect on liver function, health economics and death rate will be made. the groups will be assessed for comparability in terms of underlying disease, resection type, underlying concurrent illnesses, sex, age, background liver disease. standardisations of the rest of the operation will be carried out including anaesthetic technique and fluid requirements will be assessed by oesophageal doppler. 100 patients will be recruited.


Eligibility criteria:
inclusion criteria: * any adult patient listed for liver resection giving informed consent exclusion criteria: * children, non-consent and diminished responsibility

Keywords: liver resection blood loss resection technique cusa radiofrequency ablation health economics benign and malignant liver disease
noninvasive cardiac imaging in vasospastic angina korean registry (navigator)

Conditions: Spasm

Summary: with regard to the characteristics of spasm segment, had been clearly described by other invasive imaging methods including intravascular ultrasound and optical coherence tomography. however, there is potential risk during these invasive procedures, such as severe myocardial ischemia or fatal arrhythmia. presently available imaging test for coronary artery disease in multi detector-row computed tomography angiography (mdcta) evaluation has high diagnostic accuracy to evaluate coronary artery stenosis. however, previous report assessing imaging findings or diagnostic accuracy of mdcta in patients with vasospastic angina (vsa) is lacking.

previously investigators analyzed the characteristics of coronary spasm segment in an observational individual dataset, suspected vsa patients (n=20) underwent dual-acquisition of mdcta (initial and intravenous nitrate injected ct imaging), the diagnostic accuracy showed sensitivity: 73%, specificity: 100%, positive predictive value: 100%, and negative predictive value: 56%. further study is necessary because previous analysis presented limited sample size and deficiency of healthy control. therefore, investigators hypothesis that dual-acquisition of mdcta in noninvasive tool for coronary assessment provide more information of coronary characteristics, and the diagnostic efficacy would be non-inferior as compared with the invasive coronary imaging modality in coronary spasm-induced angina attacks.

Eligibility criteria:
inclusion criteria: * subject is onset of angina-like attack at rest, during effort, or during rest and effort. * subject has chest pain between night and early morning. * subject is scheduled to undergo mdcta. * subject is an acceptable candidate for cag with an eg provocation test. * cardiac condition: bp\>90/60mmhg, ecg: sinus rhythm with regular, left ventricular ejection fraction\>55%, and resting heart rate\<100 beats/min. * subject will be provided written informed consent. * subject is willing to comply with study follow-up requirement. exclusion criteria: * subject has clinical evidence of acute coronary syndrome. * subject has evidence of significant narrowing (\>50% stenosis by cag). * subject has clinical evidence of cardiomyopathy or valvular heart disease. * subject is hemodynamically unstable. * subject has a history of pci and cabg. * subject is pregnant and/or breastfeeding or intends to become pregnant during the duration of the study. * subject has known allergy to contrast medium. * subject has renal insufficiency (serum creatine \>2.5 mg/dl).

Keywords: mdcta coronary artery spasm
a study of cataract surgery with the femtosecond laser

Conditions: Cataract

Summary: the purpose of this study is to evaluate the feasibility of using the femtosecond laser system to perform surgical maneuvers during cataract extraction surgery.


Eligibility criteria:
inclusion criteria: * able and willing to comply with the treatment/follow-up schedule and requirements * able to understand and provide written informed consent * 3. etdrs visual acuity equal to or worse than 20/30 (best corrected) * patient age between 50 and 80 years old * pupil dilates to at least 8 mm * patient able to fixate * 1-3+ nuclear sclerotic cataract(this criterion does not apply to subjects who will receive post-iol corneal relaxing incisions) * axial length between 22 and 26 mm exclusion criteria: * pregnant, intending to become pregnant during course of study, less than 3 months postpartum or less than 6 weeks after completion of breast feeding * participation in a study of another device or drug within 3 months prior to study enrollment or during this study, and as per the investigator's careful discretion, as long as not contradictory to any of the above criteria * any condition which, in the investigator's opinion, would make it unsafe (for the subject or for the study personnel) to treat the subject as part of this research study * anterior chamber depth less than 2.5 mm via optical coherence tomography (visante, zeiss) or iol master (zeiss) measurements * history of prior ocular surgery * history of ocular trauma * co-existing ocular disease affecting vision * astigmatism greater than five diopters (d.)

Keywords: cataract femtosecond laser
correlation between circulating galactomannan and beta-d-glucan and clinical outcome of invasive aspergillosis

Conditions: Invasive Aspergillosis

Summary: the investigators hypothesize that early galactomannan and beta-d-glucan features, namely the height of the initial value at the time of diagnosis and the subsequent rate of marker decay within the first week(s) following therapy (day 7, day 14) are important factors in predicting clinical outcome.

a major challenge in the development of antifungal therapies for invasive fungal infections is the difficulty in assessing early treatment response and clinical prognosis. mycological endpoints are often unreliable, reflected by the low sensitivity of fungal cultures to diagnose infection (20% for aspergillosis). radiographic endpoints can be misleading, particularly when assessed early following treatment initiation. clinical endpoints can be ambiguous indicators of treatment response, and generally include categorization of patient outcome as better, stable or worse. furthermore, clinical assessments are likely confounded by the underlying diseases predisposing to fungal infection. thus, a biomarker interposed between the initiation of antifungal therapy and patient outcome would bring much needed precision in the evaluation of novel antifungal drugs and thus serve as a valuable tool to guide decision-taking regarding ineffective treatments and dose selection in product development. the current absence of such biomarkers represents a critical capability gap. to date, only few studies have examined the prognostic value of fungal biomarkers in invasive aspergillosis on clinical outcome and have been limited by sample seize. to address this issue, the current study will examine the correlation between the fungal biomarkers galactomannan and beta-d-glucan with clinical outcome in invasive aspergillosis. the study will also incorporate c-reactive protein (crp) levels, as they seem to be a useful surrogate marker of il-6 production. the investigator contains a sample database of 100+ patients with either probable or proven invasive aspergillosis for which daily marker levels and crp (during the first two weeks of antifungal therapy) were measured and clinical assessment data at (2, 4 and ) 6 weeks post-treatment. the study will evaluate whether serial serum measurements of galactomannan/beta-d-glucan during the first week(s) of antifungal therapy can distinguish between successful clinical outcome and failed clinical outcome at 6 weeks in patients with proven and probable invasive aspergillosis. the study aims also at exploring various cut points for galactomannan/beta-d-glucan measurements at two weeks after initiation of antifungal therapy and at exploring the sensitivity and specificity for predicting clinical outcome at 6 and 12 weeks in patients with proven and probable invasive aspergillosis.

Eligibility criteria:
inclusion criteria: * proven or probable invasive aspergillosis with positive gm antigen test exclusion criteria: * seronegative aspergillosis

Keywords: galactomannan beta-d-glucan aspergillosis outcome
clinical values of mature fistulas in hemodialysis

Conditions: Hemodialysis Access Failure; Hemodialysis Complication

Summary: the arteriovenous fistula (avf) is the preferred vascular access for hemodialysis(hd), and fistula-first is the general recommendation for all hd patients. but in clinical practice in china, quite a few patients start hd before avf maturation due to various situations. whether hd initiation with mature avf will influence the patency and complications is controversial. this study is aim to compare the avf patency in incident hd patients with mature or immature avf on hd initiation, and to compare other clinical outcomes, including abandonment without use, infection, and other avf complications occurrence.


Eligibility criteria:
inclusion criteria: * underwent initial upper-extremity avf creation for incident hd at zhongshan hospital, fudan university exclusion criteria: * with malignancies * not followed-up at zhongshan hospital, fudan university
bluewind renova istim™ system for the treatment of oab

Conditions: Treatment of Patients Suffering From Overactive Bladder (OAB)

Summary: the oasis study is prospective, interventional, multi-center study to evaluate the safety and efficacy of the bluewind renova istim™ implantable tibial neuromodulation system for the treatment of patients diagnosed with overactive bladder.


Eligibility criteria:
inclusion criteria: * female aged 18 or greater (21 in the us) * more than or equal to 6 months history of uui diagnosis * patient who is mentally competent with the ability to understand and comply with the requirements of the study exclusion criteria: * any significant medical condition that is likely to interfere with study procedures * patients who are breastfeeding * predominant stress incontinence * have a life expectancy of less than 1 year * diagnosis of interstitial cystitis or bladder pain syndrome as defined by either american urological association (aua) or european association of urology (eau) guidelines