Kornimate/medical-research-clean huggingface dataset:
genetic predictors of analgesic efficacy of propranolol for treating postoperative pain

Conditions: Postoperative Pain

Summary: this study is a randomized, double-blind, placebo controlled clinical trial. the main purpose of this study is to determine if postsurgical pain ratings are improved with treatment with oral propranolol, and if the effectiveness of treatment can be modified by the presence or absence of snps (single nucleotide polymorphism) associated with cathecol-o-methyltransferase (comt) and mu-opioid receptor (mor1) activity. the treatment period will last for three days and the observation period will last for six months. effectiveness of treatment will be assessed by means of morphine consumption through quantitative evaluation of iv-pca (patient controlled analgesia) morphine as primary outcome measure.


Eligibility criteria:
inclusion criteria: * elective laparoscopic hemicolectomy surgery. * self-reported caucasians. * asa (american society of anesthesiologists) physical status of i or ii. * agrees to provide signed and dated informed consent form. * willingness to agree with the biobanking policy. exclusion criteria: * uncontrolled medical or psychiatric conditions. * severe mental impairment. * history of major depressive disorder, psychotic disorder or schizophrenia, and/or manic episodes within the past year. * active alcoholism within the past 6 months. * psychoactive recreational drug abuse within the past 6 months including mdma, ketamine, hallucinogens such as lsd and/or sympathomimetics such as cocaine. * inability to comprehend pain assessment. * pregnancy and/or breast-feeding. * known hypersensitivity to beta blockers or opioids. * currently taking propranolol. * currently taking other hypotensive treatments. * currently taking opioids. * patients with asthma or reactive airway disease. * patients with cardiac arrhythmia, coronary artery disease, congestive heart failure. * patients with renal failure or dialysis. * patients with liver insufficiency. * heart rate less than 60bpm or diastolic blood pressure \<50 mmhg during the preoperative visit.

Keywords: comt beta-blocker hemicolectomy
laser speckle imaging for wound perfusion monitoring (woundimager)

Conditions: Wounds and Injuries

Summary: the purpose of this study is to investigate the efficacy of an optical device designed and developed to quantitatively monitor blood flow velocity of wound sites. it is hypothesized that the blood flow velocity of the wound site will provide critical information on the efficacy of hyperbaric oxygen therapy.


Eligibility criteria:
inclusion criteria * subjects age 21 or older with the following types of wounds and who are able to comply with the study requirements: * necrotizing fasciitis * compromised/failed skin grafts/flaps * chronic refractory osteomyelitis * soft tissue radiation necrosis * diabetic wounds, lower extremity * acute peripheral arterial insufficiency * crush injury * venous leg disease * pressure ulcer * other chronic, non-healing wounds * subjects must have signed the informed consent forms. exclusion criteria * female subjects who are pregnant or nursing. * anyone who is unable to give written informed consent * subjects with end-stage renal disease or who require peritoneal or hemodialysis. * subjects with current malignancies.

Keywords: diabetic wounds hyperbaric oxygen laser speckle imaging hyperbaric oxygenation
lumbar spinal fusion - web-based platform targeting anxiety and depression

Conditions: Lumbar Spine Fusion; Anxiety; Depression

Summary: the purpose of the present study is to investigate the effect of a web- based platform (wp) on anxiety and depression and health economics among patients undergoing lumbar spine fusion (lsf).

this study will seek to reduce pre- and postoperative anxiety, depression and functional impairments using alternative cognitive and educative methods, targeting the underlying factors for development of anxiety and depression. it is known that there is a rationale behind using cognitive behavioural therapy (cbt) in order to reduce pre- and postoperatively anxiety and depression. the main assumption within cbt is that patients´ perceptions create their thoughts and beliefs, which influence their feelings and subsequently their behaviour. the features of wp in this study will seek in several ways to exceed this expected behaviour modification. the preliminary choices of features on the wp are made in order to prevent catastrophic images and thereby reduce anxiety and depression. the wp will offer patients non-catastrophic images through animated information mirroring the course of treatment, which will aim to influence their beliefs, feelings and their behaviour. to examine the effect of the wp versus conventional information and course of rehabilitation, on patients' degree of anxiety and depression, a randomized controlled trial will be preformed. a total of 114 patients scheduled for elective instrumented lsf will be included and randomly assigned to the control group or to the intervention group receiving access to the wp.

Eligibility criteria:
inclusion criteria: * patients who are going to have a one-three level instrumented lumbar spinal fusion exclusion criteria: * age below 18, known psychiatric disorder, prior lsf, as the success rates of re-operations are found as low as 35%, inability to communicate in danish and finally patients with no internet connection.
percutaneous intramyocardial septal radiofrequency ablation for obstructive hypertrophic cardiomyopathy in children

Conditions: Hypertrophic Cardiomyopathy, Obstructive

Summary: the primary purpose of this study was to demonstrate the safety and efficacy of percutaneous intramyocardial septal radiofrequency ablation (pimsra) in children and assessed its performance and functional outcomes in the follow-up. this is an observational, single-arm, single-center study.

the prevalence of hypertrophic cardiomyopathy (hcm) ranks second among cardiomyopathies in children. the prognosis of hcm has been previously demonstrated to be closely correlated with age. hcm in childhood is frequently associated with severe symptoms and high mortality rates, exhibiting a 36% higher incidence of malignant ventricular arrhythmias compared to adults, and being twice as likely to necessitate advanced heart failure therapies such as heart transplantation or left heart assist devices. surgical septal myectomy can effectively help patients with drug-refractory symptoms but carries risks inherent to invasive procedures and requires expertise that is not universally available. alcohol septal ablation is not recommended for applications in the young patient group. percutaneous intramyocardial septal radiofrequency ablation (pimsra) is a new method for the treatment of hcm using a special diagnosis and treatment device on the target area of the heart under the guidance of echocardiography. the method breaks through the worldwide problem of minimally invasive treatment of the myocardium on the beating heart, thus avoiding x-ray radiation and contrast agent damage. previous research has illustrated the effectiveness and safety of pimsra for adult patients with obstructive hcm. we have found that pimsra results in sustained improvement in exercise capacity, persistent reduction in left ventricle outflow tract (lvot) gradient, and sustained improvement in cardiac function. this is an early feasibility study to evaluate the clinical safety and efficacy of pimsra in pediatric patients, as well as to assess postoperative cardiac function and exercise capacity.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of hypertrophic obstructive cardiomyopathy * age younger than 18 years * resting or provoking left ventricular outflow tract gradient ≥ 50 mmhg * drug-refractory symptoms or intolerable to pharmaceutical therapies * heart function of new york heart association ≥ class ii exclusion criteria: * secondary left ventricular hypertrophy (lvh) related to subaortic stenosis or aortic stenosis * presence of concomitant heart disease requiring surgery * left ventricular ejection fraction \<40% * cardiac resynchronization therapy within 3 months

Keywords: percutaneous intramyocardial septal radiofrequency ablation children hypertrophic cardiomyopathy
biomarkers in samples from young patients with soft tissue sarcoma

Conditions: Sarcoma

Summary: rationale: studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. purpose: this research trial is studying biomarkers in samples from young patients with soft tissue sarcoma.

objectives: * to identify the key components of driver pathways of primary and secondary soft tissue sarcomas. * to perform the next-generation sequencing on primary versus normal on undifferentiated sarcomas. outline: genomic dna and rna samples from undifferentiated sarcoma tumors are analyzed by next-generation sequencing for somatic mutations. normal matched lymphocytes and tissue are also analyzed.

Eligibility criteria:
disease characteristics: * banked childhood samples from the cog-d9902 soft tissue sarcoma biology and banking study * rhabdomyosarcoma, nos patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: metastatic childhood soft tissue sarcoma nonmetastatic childhood soft tissue sarcoma recurrent childhood soft tissue sarcoma previously treated childhood rhabdomyosarcoma previously untreated childhood rhabdomyosarcoma recurrent childhood rhabdomyosarcoma
high-resolution imaging of corneal lesions with optical coherence tomography (oct) - a pilot study

Conditions: Corneal Abrasions; Corneal Infiltrates

Summary: corneal lesions such as corneal abrasions and corneal infiltrates are common in clinical practice. the current study seeks to investigate whether high-resolution oct is suitable for imaging of these corneal lesions. the present study has the character of a pilot study and the results are intended to be used to develop a standardized protocol for imaging and analysis of these corneal lesions. based on this protocol, further studies investigating the pathophysiology of corneal lesions or evaluating therapeutic success can be planned.


Eligibility criteria:
inclusion criteria: * men and women aged over 18 years * newly diagnosed corneal abrasion or corneal infiltrate exclusion criteria: * recurrent corneal erosion * participation in a clinical trial in the previous 3 weeks * presence of any abnormalities preventing reliable measurements as judged by the investigator * any contraindication for topical application of novain 0.4% eye drops for topical anesthesia or of minims-fluorescein sodium eye drops for fluorescein staining * pregnancy, planned pregnancy or lactating

Keywords: optical coherence tomography corneal abrasion corneal infiltrate
meaning of life in hiv-infected youths

Conditions: Meaning of Life

Summary: logotherapy has never been evaluated in hiv-infected teenagers. in this study, we will evaluate the meaning of life by using the purpose in life test and the affect of logotherapy in hiv infected youth at hiv-nat, thai red cross aids research centre and king chulalongkorn memorial hospital.

in the haart era, hiv infected children can live longer and will grow up to become teenagers. however, some may develop psychosocial problems because they have lost family members, experienced poverty, social discrimination etc. being a normal teenager is tough and is the most complex period of his/her life. this is the period when most teenagers will find their identity and reasons for living. therefore it is believed that interventions may help hiv-infected teenagers better deal with life. for this study, logotherapy, a therapy that will help a person to discover his/her purpose in life, live meaningful life, and attain self-esteem was used. the success of the intervention was evaluated by using the purpose in life test.

Eligibility criteria:
inclusion criteria: 1. age 16-24 years 2. hiv seropositive 3. hiv disclosed 4. understand thai language 5. parent signed written informed consent exclusion criteria: 1. mental or psychological disorder or having active suicidal idea or attempt 2. having no permanent address

Keywords: meaning of life logotherapy hiv-infected teenagers adherence
a disease registry of patients with mantle cell lymphoma

Conditions: Mantle Cell Lymphoma

Summary: the purpose of this study is to create a patient registry in order to assess treatment patterns, physician reported clinical outcomes and patient-reported health-related quality of life among patients diagnosed with mantle cell lymphoma (mcl) who newly initiated a novel therapy in the past 6 months and whose treatment is ongoing at the time of enrollment.

newer targeted therapies (monotherapy or in combination with other agents) have been recently approved in the united states for the treatment of adult patients with mantle cell lymphoma (mcl) who have received at least 1 prior therapy. the approval of these newer therapies will have an impact on the treatment patterns, toxicity patterns, and outcomes in the mcl population. a prospective, observational study will help to better understand the evolving real-world treatment outcomes (including treatment patterns, reasons for discontinuation/dose reduction, treatment interruption or treatment switches), physician-reported clinical outcomes, and patient-reported symptoms and health-related quality of life (hrqol) among patients diagnosed with mantle cell lymphoma (mcl) who newly initiated a novel therapy in the past 6 months and whose treatment is ongoing at the time of enrollment.

Eligibility criteria:
inclusion criteria: * patient diagnosed with mantle cell lymphoma (mcl) * informed consent for participation * age ≥ 18 years old, as of the first observed diagnosis of mcl * patients for whom a clinical decision has been made to initiate novel therapy in the last 6 months, limited to the following novel agent categories: * bcl-2 inhibitors * btk inhibitors * immunomodulatory agents * phosphoinositide 3-kinase inhibitors the novel agent must have been granted approval in at least one haematological cancer. treatment must be ongoing at the time of enrollment. exclusion criteria: • patient is participating in a clinical study that prohibits participation in non-interventional studies, or where treatment is blinded, at the time of consent.

Keywords: mantle cell lymphoma registry mcl novel therapy mcl treatment patterns mcl reported outcomes
endomysial fibrosis, muscular inflammatory response and calcium homeostasis dysfunction in duchenne muscular dystrophy

Conditions: Duchenne Muscular Distrophy (DMD)

Summary: duchenne muscular dystrophy (dmd) is the most common and devastating form of muscular dystrophy, caused by an x-chromosome gene mutation resulting in the absence of the protein dystrophin. gene therapy by exon skipping or stop codon read-through and cell therapy are at the stage of clinical assays with very promising results. nevertheless, they will not allow a complete cure of dmd patients and they will concern only specific types of mutations. it is therefore crucial to develop other therapeutic strategies related to the natural history of the disease and targeted not on the dystrophin itself, but on the consequences of its absence. another crucial pathophysiological pathway in dmd is muscle cell calcium homeostasis, particularly via the ryanodine recepteur (ryr1). our study focus on the relationship between endomysial fibrosis, abnormal inflammation response and calcium homeostasis dysfunction which are not entirely established in dmd. the identification of the biological mechanisms that play a role in the severity of the phenotype, particularly endomysial fibrosis, should allow the development of targeted pharmacotherapy as a complementary strategy for the future treatment of dmd.


Eligibility criteria:
inclusion criteria: * boy between 2 to 15 years old. * lack of any infectious disease in the last week before the study. * consent form signed by parents. inclusion criteria for dmd infant * clinical suspicion of duchenne muscular dystrophy inclusion criteria for control healthy infant * lack of any antecedent of congenital cardiac, pulmonary or muscular disease including dmd. exclusion criteria: * subjects who are unable or unwilling to tolerate study constraints * parents of the subject unable or unwilling to undergo informed consent * subject with no rights from the national health insurance programme

Keywords: duchenne muscular distrophy endomysial fibrosis muscular inflammatory response calcium homeostasis dysfunction muscle biopsy
screening for early cervical cancer detection

Conditions: Cervical Cancer; Cervix Neoplasm

Summary: this study is to audit results and adherence to cervical screening program before and after the implementing awareness of the who guidelines of screening among the multidisciplinary healthcare workers and patients.

cervical cancer screening is the asymptomatic detection of pre-cancer and cancer in women at risk, with at least one screening suggested for women aged 30-49 years. according to the world health survey (2015), 19% of eligible women in developing countries and 63% of those in developed nations had their cervical cancer screening done using a pap smear or visual inspection with acetic acid (via). according to latest estimates by world health organization (who), in egypt, 866 women are diagnosed with cervical cancer every year and 373 die from the disease. cervical cancer is the 13th most common cancer in women in egypt and the 10th most common cancer in women aged between 15 to 44 years . statistics from egyptian studies provide pre invasive cervical lesion incidence levels of 0.3 % to 0.5 % . the human papillomavirus (hpv) is one of the most significant risk factors for cervical cancer. hpv can be transmitted through sexual contact, including vaginal or oral sex with an infected person. hpv has more than 100 strains, of which hpv16 and hpv18 account for about 70% of invasive cervical cancers

Eligibility criteria:
inclusion criteria: * women 20-60 years. * sexually active. * fulfilling cervical check's eligibility criteria for screening at the time of the audit https://www.cervicalcheck.ie/_fileupload/file/eligibility%20framework.pdf exclusion criteria: patient who had underwent to total hysterectomy. * pregnant or postpartum or post abortive patients * patient having any history of treatment for cervical dysplasia. * immunocompromised patients.
effects multimodal mind and body approach for mci

Conditions: Mild Cognitive Impairment

Summary: the aim of this application is to develop a computer-based multimodal mind and body approach (cmmba) for mild cognitive impairment (mci). this product will provide a new, cost-effective and easily accessible treatment option for mci and potentially other age-related dementia.

the goal of this phase i r41 (sttr) application is to develop a computer-based multimodal mind and body approach (cbmmba) to improve the cognitive function for mild cognitive impairment (mci). this application, if successful, will provide a cost-effective and easily accessible treatment option for mci and other age-related dementia, significantly improve the prevention of mci development, and directly benefit patients suffering from the highly prevalent disorder, particularly for those who may have limited access to in-person mind and body interventions.

Eligibility criteria:
inclusion criteria: 1. report of cognitive decline / complaint by the patient, the patient's informant, or the physician; 2. cognitive impairment is confirmed by objective cognitive measures (montreal cognitive assessment (moca) and neuropsychological testing), where objective cognitive impairment is defined as poor performance in one or more cognitive measures suggesting deficit in one or more cognitive domains; 3. patient has preserved independence in functional abilities (measured by informant report, completion of activities of daily living (adl) and instrumental activities of daily living (iadl) checklists); 4. not demented; exclusion criteria: 1. has severe visual or hearing impairment; 2. has pre-existing musculoskeletal or other conditions, which prohibit bdj performance and / or the application of acupressure at the selected points; 3. has suffered from a neurological disorder (e.g., severe head trauma), psychiatric disease (e.g., major depression), or any other major medical disease that could potentially compromise their cognition; 4. has had prior experience with bdj or acupressure or relaxation techniques in the past year.

Keywords: mind-body intervention baduanjin cognitive training
comparison between pioglitazone and ses with type2 dm

Conditions: Coronary Artery Disease; Type 2 Diabetes Mellitus

Summary: drug-eluting stents have been shown to decrease restenosis, but were associated with an increased rate of death, as compared with bare-metal stents. recently, thiazolidinediones effectively reduced restenosis and the risk of repeat target vessel revascularization. we conducted a study to compare the performance of a drug-eluting stent with that of a bare-metal stent with pioglitazone in patients with type 2 diabetic mellitus.

the study is a prospective cohort trial involving 38 type 2 diabetic patients referred for coronary stenting who were assigned to either the sirolimus-eluting stent group or the pioglitazone group. quantitative coronary angiography will be performed at study entry and at six months follow-up to evaluate in-stent late luminal loss and the percentage of the luminal diameter and the rate of restenosis. we also analyze major adverse cardiac events at 12 months.

Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes mellitus who had received coronary stenting were eligible for the study. exclusion criteria: * spastic angina pectoris * congestive heart failure * hepatic dysfunction * chronic renal disease * recent stroke * impaired glucose tolerance * insulin dependent diabetes mellitus * familial hypercholesterolemia * thyroid dysfunction * adrenal dysfunction * an intolerance of aspirin, ticlopidine, heparin, pioglitazone, stainless steel, or contrast material.

Keywords: bare metal stent major adverse cardiac events pioglitazone restenosis sirolimus eluting stent
non-contact proactive remote monitoring of copd exacerbations

Conditions: COPD Exacerbation

Summary: the goal of this observational study is to determine if a copd exacerbation can be detected early in its onset. the main questions it aims to answer are: * can an exacerbation be detected before the person recognizes they are unwell? * what are the biological signals which provide the best indication of decompensation? * how does this indication of decompensation compare to a daily cat? participants will be asked to place a device, distasense, on top of their mattress and then sleep as normal. in addition, they will be asked to complete a daily cat.


Eligibility criteria:
inclusion criteria: 1. confirmed diagnosis of copd 2. 1 or more exacerbation in the last year 3. aged over 18 years 4. willing to use monitoring devices and complete study questionnaires 5. adequate english 6. signed consent form exclusion criteria: 1. pregnancy 2. bmi greater than 45 kg/m2 3. nil other, provided inclusion criteria are met.