Kornimate/medical-research-clean huggingface dataset:
implementation of a program based on adapted physical activity and recommendations for second cancers prevention for tyacs

Conditions: Neoplasms

Summary: about 700 new cases of cancer are recorded each year among tyac aged 15 to 25 years old in rhône-alpes region (france); more than 200 are treated and supported within the tyac department of the institute of hematology and oncology pediatrics (centre léon bérard-civil hospice of lyon). these patients survive from their disease in 80% of cases; they have six times more likely to develop a risk of second primary cancer (scp) than their peers. this risk of scp is multifactorial and varies depending on the type of first cancer, treatment received and the prevalence of risk factors (smoking, overweight, sedentary lifestyle, environmental exposures...). this project aims to implement a clinical program based on adapted physical activity (apa) and cancer prevention recommendations for tyac during the active treatment period (4-6 months). the methodology used series of assessments of apa sessions and information meetings dedicated to cancer prevention and scp risk recommendations. it mobilizes regularly the health care team of tyac department, tyac associations, sports structures and associations involved in cancer prevention at the regional level. assessment of tyac satisfaction regarding the project, benefits in terms of exercise practice, and knowledge improvement on cancer prevention recommendations, are assessed throughout the program.


Eligibility criteria:
inclusion criteria: * with neoplasms, histologically confirmed * whose ability to participate in the apa intervention has been certified by a medical certificate issued by physician, the referring physician or the physician investigator * covered by a medical insurance * written, signed informed consent exclusion criteria: * cons-indication to physical activity practice, at discretion of the investigator

Keywords: adolescent and young adult
comparison of two protocols of optimization of x ray radiations in pediatric interventional neuroradiology

Conditions: Occlusion or Malformation of a Cerebral Vessel

Summary: interventional neuroradiology replaces surgery. this technology requires various exposition to x rays : number of x rays photographs, radioscopy, distance between patient and detector, speed of acquisition of x-rays photographs, high tension and intensity. the manipulator must find the right balance between quality of photographs and dose delivered to the patient (optimization). children are particularly exposed to these risks of irradiation (sensitivity to x-rays and long life expectancy with risks. so, it is fundamental to optimize the dose delivered during the procedures. the investigators propose to analyse a study comparing two protocols of optimization of doses. the investigators' hypothesis is that the protocol experimented in this trial allows less radiation of the children, compared to the usual protocol.


Eligibility criteria:
inclusion criteria: * malformation or occlusion of a cerebral vessel requiring interventional neuroradiology exclusion criteria: * opposition ot the parent(s) to the participation of their child in the trial and/or no social security.
genetic study of insulin-like growth factor-i receptor mutations in patients with intrauterine growth retardation

Conditions: Intrauterine Growth Retardation

Summary: objectives: i. determine if mutations in the gene encoding the insulin-like growth factor-i receptor lead to relative insulin-like growth factor-i insensitivity and produce intrauterine growth retardation in children.

protocol outline: patients undergo blood draw. insulin-like growth factor-i (igf-i) and insulin-like growth factor binding protein-3 (igfbp-3) are measured. patients whose igf-i and igfbp-3 levels are average or above are tested for the presence of mutation in the insulin-like growth factor-i receptor.

Eligibility criteria:
* intrauterine growth retardation (iugr), defined as birth weight less than 2 standard deviations below the mean by usher and mclean deficient "catch-up" growth (stature less than 5th percentile on growth chart after age 18 months) normal or elevated circulating concentrations of insulin-like growth factor-i (igf-i) and insulin-like growth factor binding protein-3 (igfbp-3) igf-i or igfbp-3 within or above the 95th percentile confidence interval for age no other clinical explanation for poor prenatal and postnatal growth no iugr due to maternal toxemia, endocrine disease, gastrointestinal disease, significant heart disease, or chromosomal abnormalities no other condition known to retard growth

Keywords: endocrine disorders intrauterine growth retardation rare disease
fluoridated milk and enamel caries in adolescents

Conditions: Caries,Dental

Summary: the goal of this trial is to investigate whether low daily doses of fluoridated milk, in addition to oral hygiene routines with fluoridated toothpaste, can prevent caries development in adolescents' teeth. the main questions it aims to answer are: * does fluoridated milk lower the number of caries lesions in teeth over time? * does fluoridated milk lower the number of enamel caries lesions over time? researchers will compare an intervention group receiving doses of fluoride in water to add to milk and a control group receiving water to add to milk. the 12-13 year participants will: * be examined at a baseline and once yearly up to 2 years * be provided directly with the doses every second month at their dental clinic * take the fluid daily

during the study, the participants were asked to continue with their usual oral hygiene regimes, including tooth-brushing twice a day with toothpaste containing fluorides as recommended by the swedish national board of health and welfare. at their yearly visit to their dental clinic the participants were asked about their health status, use of antibiotics, lactose intolerance, daily consumption of milk, tooth brushing frequency, type of toothpaste and use of other fluoride additives. information on adverse effects (dental pain, visit to other dental clinic, and antibiotics due to dental infection) was collected. caries registration was performed by visual-tactile and radiographic examinations at baseline and 1 and 2 years. visual-tactile examination was performed by a dental practitioner under lighting with a mirror and occasionally with a probe. caries status was classified for the occlusal/incisal, buccal and lingual surfaces and the proximal surfaces of incisors and cuspids according to the icdas criteria with code 0 (for sound), 1-3 (for enamel caries) and 4-6 (for dentine caries). icdas is an internationally applied system for caries detection used clinically (the international caries detection and assessment system (icdas): an integrated system for measuring dental caries (reference). radiographic examination of the proximal surfaces of premolars and molars with one bitewing radiograph on each side of the mouth took place in the same session.

Eligibility criteria:
inclusion criteria: * adolescents of both sexes, aged 12-¬13 * healthy (no oral disease or systemic disease possibly affecting the oral cavity). health declaration used in the dental clinic was utilized to confirm health status * adolescents with permanent posterior teeth/no primary molar teeth present and second premolars in contact with the mesial surface of the first molars * adolescents who, together with their parents or guardians, gave informed written consent to participate. data confidentiality and the right to withdraw from the study at any time were warranted to the adolescents in writing. exclusion criteria: none

Keywords: adolescents flouridated milk caries prevention enamel caries bitewing radiography
efficacy of dialectical behavior therapy in patients with borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: the purpose of this study is to test the hypothesis: primary hypothesis: participants in the dialectical behavior therapy group have greater reductions in the frequency and severity of suicidal and non-suicidal self-injurious behaviors compared to participants in the alternative treatment group. secondary hypotheses: participants in dialectical behavior therapy group have improved treatment outcomes compared to participants in alternative treatment, including mental health service utilization, symptoms of borderline personality and depression symptoms, suicidal thought and hopelessness, disability, and quality of life.

this study will be a 3-year randomized control trial. patients will be referred from any mental health services in taipei area who meet diagnostic and statistical manual of mental disorders, fourth edition, text revision criteria for borderline personality disorder. inclusion criteria include subjects who fulfill the diagnostic and statistical manual of mental disorders, fourth edition, text revision criteria for borderline personality disorder, 18-60 years of age, sign the informed consent, have had at least two episodes of suicidal or non-suicidal self-injurious episodes in the past 5 years, and at least one of which is in the 3 months preceding enrollment. the exclusion criteria include psychotic disorder, bipolar i disorder, severe physical illness, and mental retardation. outcome measures will be obtained at pre-treatment, 4-month, 8-month and post-treatment (12-month) during 1-year protocol. using semi-structured interview and a battery of self-report forms, a range of symptoms and behaviors associated with borderline personality disorder will be assessed including suicidal thought, suicide attempt, depression, hopelessness, quality of life, disability, service utilization, and function. measures are selected based on previous outcome studies of dialectical behavior therapy. outcome variables will be evaluated by blinded assessors.

Eligibility criteria:
inclusion criteria: * meeting dsm-iv criteria for borderline personality disorder * 18-60 years of age * have had at least two episodes of suicidal or non-suicidal self-injurious episodes in the past 5 years, * at least one episode of suicidal is in the 3 months preceding enrollment * agreement to participate in evaluation of the program. exclusion criteria: * bipolar i disorder, delirium, dementia, mental retardation, or a diagnosis of substance dependence in the preceding 30 days * living outside of taipei area * having any serious medical condition likely to require hospitalization within the next year (e.g. cancer) * and having plans to leave the taipei area in the next 1 year
efficacy and safety of telbivudine 600mg tablets in chinese patients with chronic hepatitis b

Conditions: Chronic Hepatitis B

Summary: the "chinese pac" study (cldt600acn03) will evaluate the efficacy and safety of open label telbivudine in 2,200 compensated chronic hepatitis b (chb) adults. the primary objective of the study is the proportion of patients achieving undetectable hbv dna at week 52.


Eligibility criteria:
inclusion criteria: * male or female 16 to 65 year of age * documented chb defined by detectable serum hbsag and serum hbv dna level * willing and able to comply with the study drug regimen * written informed consent before any assessment exclusion criteria: * patient has a history of/or clinical signs/symptoms of hepatic decompensation * patient has a history of hcc or findings suggestive of possible hcc * patient has received treatment of nucleoside or nucleotide drugs whether approved or investigational at any time * history of hypersensitivity to any of the drugs (telbivudine) or to drugs of similar clinical classes * patient has received ifn or other immunomodulatory treatment with 12 months before screening * previous treatment history with nrtis other protocol-defined inclusion/exclusion criteria may apply.

Keywords: chronic hepatitis b adult hbv dna suppression telbivudine
self-assessment of olfactory disorders for french speaking patients

Conditions: Post-viral Anosmia; Post-traumatic Anosmia; Chronic Rhinosinusitis; Idiopathic Anosmia; Age-related Loss of Smell

Summary: sense of smell disorders are common and are said to affect up to 20% of the general population. they are often disabling and have a real impact on the quality of life. smell disorders are most often assessed using a visual analogue scale and more rarely with objective tests (sniffing stick test). many ent units do not have these objective tests because they are time-consuming and are not covered by health insurance. some teams, such as that of dr thomas hummel of the carl gustav carus university clinic in dresden germany, have developed self-assessment questionnaires for the sense of smell in order to improve the overall care of patients with olfactory disorders. two of these self-questionnaires seem to us to be particularly relevant for use in everyday practice. since then, these questionnaires have already been validated in different languages (english, chinese, korean...), but have never been translated and validated in french. translating and validating these questionnaires into french would make it possible to improve the management and follow-up of french patients with olfactory disorders and to assess the impact of loss of smell on their quality of life.


Eligibility criteria:
inclusion criteria: * patient \> 18 years old * patient affiliated to a sickness insurance social protection scheme, beneficiary or rightful claimant * patient who has not expressed his or her opposition to the collection and processing of his or her data for research purposes after the investigator has provided informed information. * patient presenting an olfactory dysfunction of any acquired aetiology that has been evolving for at least 3 months without total recovery (case group). * patient with no sense of smell problems followed up in ent for another pathology that does not affect the sense of smell (control group). exclusion criteria: * patient in an emergency or life-threatening situation * patient under judicial protection * patient under guardianship or trusteeship * inability to provide informed information to the patient (patient does not speak or understand french) * patient with congenital syndromic or non-syndromic congenital anosmia

Keywords: olfactory disorders self-assessment quality of life olfactory capacities
loteprednol ophthalmic base compared to loteprednol ophthalmic suspension vs placebo in an allergen challenge

Conditions: Allergic Conjunctivitis

Summary: the purpose of this study is to evaluate the efficacy of loteprednol etabonate ophthalmic base, compared to loteprednol etabonate ophthalmic suspension, and vehicle in the prevention of the signs and symptoms of allergic conjunctivitis in a modified conjunctival allergen challenge model and in an environmental model during pollen season. comparisons will be made following 2 weeks of dosing.


Eligibility criteria:
inclusion criteria: * positive history of ocular allergies and positive skin test reaction to cat hair, cat dander, grasses, ragweed, and/or trees within the past 24 months. * calculated best-corrected visual acuity of 0.70 logmar or better in each eye as measured using the etdrs chart. * positive bilateral conjunctival allergen challenge(cac)reaction within 10 minutes of instillation of the last titration of allergen at visit 1. * positive bilateral cac reaction in 1 out of 3 time points for the initial and re-challenge at visit 2. exclusion criteria: * known contraindications or sensitivities to the study medication or its components. * any ocular condition that, in the opinion of the investigator, could affect the subjects safety or trial parameters. * use of disallowed medications during the period indicated prior to study enrollment or during the study.
efficacy testing of collagen and zhuyin drinks

Conditions: Skin Condition

Summary: to assess collagen and zhuyin drink on skin \& body condition improvement


Eligibility criteria:
inclusion criteria: * healthy adults aged above 20 years old exclusion criteria: * subject who is not willing to participate in this study. * patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history). * subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. * female who is pregnant or nursing or planning to become pregnant during the course of the study. * received facial laser therapy, chemical peeling or uv overexposure in the past 4 weeks. * vegetarian * subjects who have large spots (area \>3 square centimeter) or abnormal acne.
effects of vibration therapy in addition to routine physical therapy in patients with diabetic neuropathy

Conditions: Diabetic Peripheral Neuropathy

Summary: the study is aimed to determine the effects of sole-foot vibration therapy on pain intensity, static and dynamic balance, functional status and satisfaction to the intervention applied on patients with peripheral neuropathy due to type 2 diabetes mellitus.

peripheral diabetic neuropathy has disastrous effects on human body. it causes impairment which makes normal functioning and activity of daily life difficult. vibration therapy improves neural mechano-sensitivity to promote movement and function. in pakistan, researches have been conducted only on whole-body vibration and no data is available on foot-sole vibration therapy which is convenient to apply and appropriate for patients as there will be no fear of fall associated during treatment. therefore, the aim of this study is to analyze the effects of vibration therapy, applied locally on foot, on pain management, balance adjustment, function and satisfaction to treatment in patients with diabetic neuropathy.

Eligibility criteria:
inclusion criteria: * age of 40-75 years * both male and female participants * on oral medicine for diabetes * hba1c \<8.5%, and controlled blood sugar in the last three months * patients with \< 6 years from diagnosis of diabetes * diagnosed patient of peripheral neuropathy having type 2 diabetes by registered medical practitioner * patient is able to stand on both feet. exclusion criteria: * systemic diseases such as advanced cardiovascular, renal, or hepatic diseases * open wounds/ulcers on lower limb * neurological illness that affects balance i.e. vertebral artery syndrome, multiple sclerosis, parkinson's disease, alzheimer's disease, stroke and cerebral ataxia * musculoskeletal problems such as leg length discrepancy, ankle sprain and severe osteoarthritis of knee and hip joints * patients who have performed vibration therapy exercises prior to intervention * patient under any antihypertensive drugs and blood pressure more than 160/95 mm hg

Keywords: diabetes mellitus vibration therapy diabetic neuropathy pain balance functional disability patient satisfaction routine physical therapy
ultrafiltration versus iv diuretics in worsening heart failure

Conditions: Heart Failure (for Example, Fluid Overload); Heart Failure; Fluid Overload

Summary: the reverse-hf study is a randomized controlled trial to evaluate clinical outcomes of adjustable ultrafiltration with the aquadex system as compared to adjustable iv loop diuretics in patients with worsening heart failure (hf) and fluid overload.


Eligibility criteria:
inclusion criteria: * 18 years or older * man, or non-pregnant woman * admitted to the hospital with a diagnosis of acute decompensated heart failure * on regularly prescribed oral loop diuretics, sodium-glucose cotransporter-2 (sglt2) inhibitors or a mineralcorticoid receptor antagonists (mra) prior to admission * fluid overload manifested by at least three clinical indications (e.g., edema, an excess of at least 10 pounds of fluid, etc.) * provide written informed consent exclusion criteria: * new diagnosis of heart failure * acute coronary syndromes * creatinine ≥ 3.0 mg/dl or planned renal replacement therapies at the time of enrollment * contraindications to systemic anticoagulation * severe concomitant disease expected to prolong hospitalization or cause death in less than 90 days * sepsis or ongoing systemic infection * active myocarditis * constrictive pericarditis or restrictive cardiomyopathy * severe aortic stenosis * any condition in the opinion of the investigator that would prevent the patient from follow-up/survival

Keywords: heart failure fluid overload
serum biomarkers in diagnosis of mesothelioma

Conditions: Mesothelioma

Summary: in this study, the investigators analyzed the efficiencies of hyaluronan, osteopontin, c-erc/mesothelin, n-erc/mesothelin and syndecan-1 serum levels, both individually and in combination, in distinguishing malignant pleural mesothelioma patients from patients with metastatic malignant pleural diseases, benign pleural diseases, and benign asbestos pleurisy.

in the year 2002, a database for the pleural diseases was constructed to be prospectively filled in the department. the findings, outcome features and characteristics of follow-up for all cases with pleural diseases have been recorded in this database. the patient data, including epidemiological characteristics, smoking status, history of other diseases and co-morbid conditions, previous asbestos exposure, medications and additional physical and radiological examination findings, including computed tomography scans, both serum and pleural fluid laboratory investigational data and indications of invasive procedures, were recorded in the database mentioned above. the methods employed in the diagnosis of patients; any complications; characteristics such as the stages of diseases, treatments, and course of treatments; and results were also recorded in the database. from the date of the first database establishment, a "tissue, blood, serum, and fluid specimen bank" was constructed; tissue, blood, serum and pleural fluid samples of patients, which had been taken at the beginning of diagnosis process, were stored in this bank at -80°c. the blood, serum, and pleural fluid samples of patients were stored during the diagnosis process, and if conducted, pleural tissue samples taken during invasive procedures were also stocked.

Eligibility criteria:
inclusion criteria: * patients with a definite pleural diseases * age more than 18 year-old, less than 85 year-old. * willingness to participate in the study. exclusion criteria: * patients with undiagnosed pleural diseases. * age less than 18 year-old or more than 85 year-old.

Keywords: mesothelioma, pleural diseases, mesothelin, osteopontin, hyaluronan, syndecan-1