Kornimate/medical-research-clean huggingface dataset:
music during diagnostic hysteroscopy

Conditions: Pain; Anxiety; Tolerability

Summary: office hysteroscopy is associated with a level of anxiety that could condition tolerability of the procedure by the patient. the aim of this study is to evaluate the impact of music on anxiety state, expected and received pain by patients during office hysteroscopy.


Eligibility criteria:
inclusion criteria: * patients candidates for office hysteroscopy in menopausal status or in childbearing age exclusion criteria: * previous diagnostic hysteroscopy and/or rcu * current or recent pelvic inflammation * invasive cervix cancer * ongoing pregnancy
beverages and societal health

Conditions: Cardiovascular Disease, Obesity

Summary: the overall aim of the study is to compare the effects of three types of beverages - sugar-sweetened (ssb), artificially sweetened (asb), and unsweetened (usb) - on cardiovascular disease (cvd) risk factors and body weight among young adults.

consumption of sugar sweetened beverages (ssb) has been linked to obesity and, independent of body weight, risk for diabetes and cardiovascular disease. with rising public health awareness of these potential adverse effects, consumption of artificially sweetened beverages (asb) has increased dramatically. these low-calorie products are marketed as "diet," with the implication that they promote weight loss and improved health. however, there are no long-term experimental studies of asb and body weight or any other health outcome. several recent prospective observational studies have linked intake of asb to increased risk of the metabolic syndrome, type 2 diabetes, and obesity. in the proposed clinical trial, 270 young adults who habitually consume ssb will be randomly assigned to one of three groups: 1) to continue consuming habitual levels of ssb; 2) to substitute asb for ssb; or 3) to substitute unsweetened beverages for ssb. each group will receive home delivery of the targeted beverage for 1 year, using methods that build upon previous successful work. careful attention will be given to assuring treatment fidelity, equivalence of treatment intensity, and avoidance of experimental confounders. the primary study endpoint will be the ratio of serum triglyceride to hdl-cholesterol concentrations. secondary endpoints will include changes in other cardiovascular disease risk factors, body weight, dietary quality, and taste preferences.

Eligibility criteria:
inclusion criteria: * aged 18 to 40 years * consumption of at least 12 fluid ounces of sugar-sweetened beverage per day * willingness to consume types of beverages consistent with group assignment * body mass index (bmi) ranging from 18.5 - 40 kg/m2, and body weight ≤275 pounds * access to a working telephone or cell phone exclusion criteria: * intention to move away from the greater boston area during the projected period of study enrollment (i.e., 1 year post-randomization) * plans to be away from home for 5 weeks or longer during the study period (e.g., moving away from the greater boston area during the summer) * physician diagnosis of a major medical illness, eating disorder, or phenylketonuria (pku) * chronic use of any medication that may affect one or more study endpoints * impaired fasting glucose (ifg, fasting blood glucose ≥110 mg/dl) * current moderate or heavy smoker (\>10 cigarettes per day) * another member of the family (i.e., first degree relative) or household participating in the study if female, * pregnant in the past 12 months or planning to become pregnant during the study period * lactating in the preceding 3 months * change in birth control medication in previous 3 months or plans to change during the study period
a comparison of two psycho-educational group interventions for tinnitus patients

Conditions: Tinnitus

Summary: participants will be randomized into one of three groups: 3-session cet intervention, 3-session act intervention, or waiting list group. each weekly session will last up to 2 hours and 10 participants will be assigned to each group. there will be two cohorts, with 30 participants in each cohort. the waiting list group will receive the cet intervention after the groups have completed theirs.


Eligibility criteria:
inclusion criteria: * tinnitus lasting more than 3 months * hebrew speaking * use hearing aids if needed * signed informed consent exclusion criteria: * none
the role of mns in improving motor performance

Conditions: Stroke

Summary: many studies have demonstrated the usefulness of repetitive task practice by using robotic devices, including lokomat, for the treatment of lower limb paresis. virtual reality (vr) has proved to be a valuable tool to improve neurorehabilitation training. our pilot randomized clinical trial aimed at evaluating the correlation between the modifications of brain oscillations during a vr neurorehabilitative training of gait and the motor function recovery in patients with chronic stroke. twenty-four patients suffering from a first unilateral ischemic stroke in the chronic phase were randomized into two groups. one group performed 40 sessions of lokomat with vr (ragt+vr) whereas the other group underwent lokomat without vr (ragt-vr). outcomes (clinical, kinematic, and event-related synchronization, ers, and desynchronization, erd, at the eeg) were measured before and after the robotic intervention. the robotic-based rehabilitation combined with vr could be associated with improvements in several measurements of lower limb function, gait, and balance in patient with chronic hemiparesis. moreover, ers/erd analysis can be proposed as a tool to monitor motor performance and to develop non-invasive brain-computer interfaces controlling robotic devices.


Eligibility criteria:
inclusion criteria: * age ≥55 years * a first-ever ischemic supra-tentorial stroke (confirmed by mri scan) at least 6 months before their enrollment; * an unilateral hemiparesis, with a muscle research council -mcr- score ≤3 * ability to follow verbal instructions, with a mini-mental state examination (mmse) \>24 * a mild to moderate spasticity according to a modified ashworth scale (mas) ≤2 * no severe bone or joint disease * no history of concomitant neurodegenerative diseases or brain surgery. exclusion criteria: * severe cognitive and behavioral impairments * severe osteoporosis and previous bone fractures
online food and beverage labels and vending machine selections

Conditions: Food Preferences; Obesity; Weight Gain

Summary: the aim of this study is to compare the impact of 5 different types of front of package (fop) food and beverage labels: 1) calorie labels \[control\], 2) green labels on healthy foods, 3) red/yellow/green labels on less healthy/moderately healthy/healthy foods, 4) physical activity calorie equivalent labels, and 5) "high in" nutrient warning labels) on consumers' beverage and snack selections.

this project involves an online randomized experiment. we are working with an external survey company that will recruit 8,000 participants to complete an online survey in which they will be randomized to one of the five different label conditions: 1) calorie labels (control condition); 2) single green traffic light labels (on healthy foods); 3) multiple traffic light labels (red traffic light labels applied to less healthy foods, yellow applied to moderately healthy foods, and green on healthy foods); 4) physical activity labels (calorie content displayed in terms of physical activity equivalents); 5) "high in" warnings (applied to all products exceeding thresholds for calories, saturated fat, sugar, or sodium content). participants will be instructed to select products to purchase in a mock vending machine. after purchasing their products, they will be asked to answer questions about their perceptions of the different labels.

Eligibility criteria:
inclusion criteria: * participants will be us adults * ages 18 or older * with an over-sample of adults with lower educational attainment (some college or less) exclusion criteria: * younger than 18 * non-us * educational quota filled

Keywords: food labeling sugar-sweetened beverages eating drinking choice behavior
preventive application of gnrh antagonist on early ohss

Conditions: Ovarian Hyperstimulation Syndrome; GnRH Antagonist; Aspirin; Vascular Endothelial Growth Factor; Pigment Epithelium Derived Factor

Summary: ovarian hyperstimulation syndrome is an iatrogenic complication of controlled ovarian stimulation. ovarian hyperstimulation syndrome prevention is a multistage process and more important than treatment.preventive administration of gnrh antagonist for high risk ohss patients from the day of oocyte retrieval is not investigated. besides, the relevant mechanism is not clear yet. here we designed a prospective randomized study to investigate whether gnrh anatagonist treatment after oocyte retrieval is more effective in preventing early ovarian hyperstimulation syndrome development than traditional aspirin preventive administration in women at high risk for ohss.

ovarian hyperstimulation syndrome is an iatrogenic complication of controlled ovarian stimulation. early ovarian hyperstimulation syndrome (ohss) occurs during luteal phase of controlled ovarian stimulation within 9 days after human chorionic gonadotropin trigger and reflects an acute consequence of this hormone on the ovaries.ovarian hyperstimulation syndrome prevention is a multistage process and more important than treatment.recently the administration of gnrh antagonists during the luteal phase of in vitro fertilization cycles offers another therapeutic modality for patients with severe early ohss.however, preventive administration of gnrh antagonist for high risk ohss patients from the day of oocyte retrieval is not investigated. besides, the relevant mechanism is not clear yet. here we designed a prospective randomized study to investigate whether gnrh anatagonist treatment after oocyte retrieval is more effective in preventing early ovarian hyperstimulation syndrome development than traditional aspirin preventive administration in women at high risk for ohss.

Eligibility criteria:
inclusion criteria: * number of oocyte retrieval more than 25; * estradiol level higher than 5000pg/ml on the day of human chorionic gonadotropin administration; * clinical or ultrasonography proven ovarian hyperstimulation syndrome on the day of oocyte retrieval. exclusion criteria: * contraindications to gnrh antagonist; * coasting or other preventive measures for managing ovarian hyperstimulation syndrome had been applied; * gnrh agonist for trigger.
prediction of outcome by echocardiography in left bundle branch block

Conditions: Left Bundle-Branch Block

Summary: patients with left bundle branch block have an increased risk for the development of heart-failure and death. however, risk factors for unfavorable outcomes are still poorly defined. this study aims to identify echocardiographic parameters and ecg characteristics by machine learning in order to develop individual risk assessment

the project investigates patients with left bundle branch block (lbbb) which describes a specific block in the electrical conduction system, where the electrical impulses must follow a detour, with the result that different parts of the heart-muscle do not contract at the same time. this condition is called left ventricular dyssynchrony. lbbb can be found in people who are otherwise completely healthy and need not have any practical consequences. in others lbbb is present in patients with different heart diseases such as after myocardial infarctions or other diseases involving the heart-muscle. patients with implanted pacemakers have a similar failure in the conduction system. both conditions can increase the risk for development of heart-failure and cardiovascular death. dyssynchrony can be treated with a special pacemaker (cardiac resynchronisation therapy, crt) in addition to regular medical treatment. the therapy is well established and has shown to reduce morbidity and mortality and even reverse heart-failure in some patients completely. however, the patients in need and responding to crt treatment is still not optimally defined. new echocardiographic parameters based on strain imaging such as regional myocardial work are able quantify the degree of dyssynchrony and give new insights into the interplay of activation delay through the lbbb and loading conditions and weakness of the myocardium due to other diseases. these new and complex measures can be integrated with clinical information by machine learning (ml) as a promising tools for accurate patient selection for crt. the project aims to find markers on ultrasound improved by ml based selection to distinguish those patients who have problems associated with the branch block from those who remain stable. this will facilitate both, an optimized patient selection for crt treatment and follow-up schedule for those who have a stable condition.

Eligibility criteria:
inclusion criteria: * qrs complex \>130 ms and r-wave duration in * v6 \>70 ms * ventricular pacing\>50% * previously implanted cardiac resynchronisation therapy (crt) exclusion criteria: * typical right bundle branch block. * no ability to give informed consent, * non-cardiovascular co-mobidities with reduced life-expectancy \< 1 year * patients with complex congenital heart disease.

Keywords: left bundle branch block strain-imaging myocardial work assessment machine learning
extravascular lung water index in severe sepsis

Conditions: Severe Sepsis

Summary: to investigate whether extravascular lung water index (evli) is an independent predictor for multiorgan dysfunction syndrome (mods) in patients with severe sepsis and to determine if increased evli may serve as an predictor for mods and mortality in those patients.


Eligibility criteria:
inclusion criteria: * all enrolled patients were recruited consecutively on the day of micu admission and within 24 hours of the diagnosis of severe sepsis. exclusion criteria: * pregnancy, * age less than 18 years old, and * uncontrolled malignancy.

Keywords: severe sepsis, intensive care units
acquired epidermodysplasia verruciformis (ev) syndrome in hiv-infected pediatric patients

Conditions: Flat Warts; HIV

Summary: many human immunodeficiency virus (hiv)-positive children are afflicted with diffuse flat warts that have been recalcitrant to multiple treatments.the aim of this prospective study was to evaluate the efficacy, safety and tolerability of 15% glycolic acid lotion (neostrata) for treatment of flat warts in hiv-positive children in botswana. additionally, the investigators characterized the flat warts in this population, including human papillomavirus (hpv) type(s) and degree of immunosuppression within the patients.


Eligibility criteria:
inclusion criteria: * male or female hiv-positive patients 7 years of age or older with at least 15 flat warts, diagnosed clinically by one dermatologist (rlm), on the face and/or dorsal hands were included in the study. exclusion criteria: * key exclusion criteria included current use of potential wart treatments or other topical otc products on the affected area(s).

Keywords: the efficacy, tolerability and safety of 15% glycolic acid lotion for treatment of diffuse flat warts among hiv+ children were investigated
effect of uterine massage versus sustained uterine compression on blood loss after vaginal delivery

Conditions: Postpartum Hemorrhage

Summary: the purpose of this study is to compare trans-abdominal uterine massage to sustained uterine compression after vaginal delivery with respect to blood loss and maternal pain. it is a randomized controlled trial that will be conducted at the american university of beirut medical center - delivery suite.

women allocated to either the massage or compression group will be given 10 units of oxytocin intramuscularly immediately after delivery of the shoulder and controlled cord traction will be performed to assist placental delivery. the umbilical cord will be clamped and cut approximately 1 minute after delivery of the baby. the uterine fundus will be rubbed and blood clots expelled as quickly as possible after delivery of the placenta.

Eligibility criteria:
inclusion criteria: * women giving birth vaginally, aged between 20 and 40 years, with a singleton pregnancy, gestational age of 36 or more weeks, and with fewer than or equal to three previous childbirths. exclusion criteria: * exclusion criteria include multiple gestation, fetal malpresentation, the third stage of labor lasting more than 30 minutes, a previous cesarean delivery, chorioamnionitis, three or more previous induced abortions, preeclampsia, fetal death, polyhydramnios, hemoglobin of 9 g/l or less before delivery, coagulopathy, on magnesium sulfate infusion, abruptio placentae and having an abdominal wall too thick to palpate the fundus of the uterus or to perform uterine massage or compressions after delivery.

Keywords: uterine massage compression
automated inhaler monitoring for asthma medication usage

Conditions: Asthma

Summary: the goal of this clinical trial is to evaluate the aflo™ digital platform's ability to improve inhaler use technique and asthma control for children, adolescents, and adults with uncontrolled asthma. the main questions the trial aims to answer are: 1. does the platform improve medication adherence and inhaler technique, as measured by the inhaler proficiency score (ips)? 2. does the aflo™ platform improve asthma control, as measured by changes in the asthma control test (act) and lung function tests (fev1, pef)? participants will: * use the aflo™ sensor with their asthma inhaler to receive real-time feedback on technique and medication adherence reminders. * track asthma symptoms and quality of life through a mobile app. * complete assessment visits and surveys at the start and end of the 3-month study and 2 interim asthma assessment phone calls.


Eligibility criteria:
inclusion criteria: 1. youth or adult with a diagnosis of persistent asthma by a physician. 2. evidence of uncontrolled asthma as defined by an act score of less than 19 and an fev1/fvc ratio of less than 80% by an asthma provider within the past 3 months, all while on controller asthma therapy 3. females or males between the ages of 10 years and older 4. participant or caregiver must have an apple and/or android smart phone with operating system 4.3 or above and data plan for the duration of the study period exclusion criteria: 1. participants with other cardiac, pulmonary with exception of asthma, neuromuscular disorders that impact breathing, or other conditions that hinder patient to perform spirometry. 2. participants with severe neurobehavioral, neurodevelopmental, or psychiatric disorders requiring special assistance 3. the participant's guardian or the patient has comprehension or language difficulties that prevent understanding of study materials (available in english) or effective training on the app or device. 4. patients are currently receiving biologic therapies for asthma management or other allergic diseases.

Keywords: asthma inhalers quality control digital health
a trial to evaluate the efficacy and safety of formoterol fumarate 20 mcg/0.5 ml in the treatment of patients with copd

Conditions: COPD

Summary: the purpose of this study is to determine the safety and efficacy of the investigational drug in comparison with a placebo.


Eligibility criteria:
inclusion criteria: * medical diagnosis of copd * current or prior history of cigarette smoking exclusion criteria: * medical diagnosis of asthma * chest x-ray diagnostic of significant disease other than copd * significant condition or disease other than copd

Keywords: copd chronic obstructive pulmonary disease formoterol
a study of induction and maintenance treatment with mabthera (rituximab) in patients with indolent b-cell nonfollicular lymphomas

Conditions: Non-Hodgkin's Lymphoma

Summary: this study will evaluate the efficacy and safety of mabthera in combination chemotherapy, followed by maintenance treatment with mabthera. the anticipated time on study treatment is 1-2 years, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * adult patients 18-65 years of age; * previously untreated indolent nonfollicular non-hodgkin's lymphoma; * active disease; * \>=3 involved sites. exclusion criteria: * typical chronic lymphocytic leukemia; * other malignancies within 3 years before study, except basal or squamous cell skin cancer or cancer in situ of the cervix; * systemic corticosteroid use for \>1 month; * significant cardiovascular disease; * central nervous system involvement; * hepatitis b or c virus infection, or hiv infection.
investigating the pharmacokinetics, safety and tolerability after a single subcutaneous injection of semaglutide in subjects with mild, moderate or severe hepatic impairment compared to subjects with normal hepatic function

Conditions: Diabetes; Diabetes Mellitus, Type 2; Hepatic Impaired

Summary: this trial is conducted in europe. the aim of this trial is to investigate the pharmacokinetics (the exposure of the trial drug in the body), safety and tolerability after a single injection of semaglutide in subjects with mild, moderate or severe hepatic impairment compared to subjects with normal hepatic function.


Eligibility criteria:
inclusion criteria: * male or female, age at least 18 years at the time of signing informed consent * body mass index (bmi) 18.5-40.0 kg/m\^2 (both inclusive) * only for subjects with hepatic impairment (mild, moderate and severe): a diagnosis of cirrhosis due to parenchymal liver disease, classified as child-pugh grade a,b or c as assessed by investigator and which is confirmed and documented by medical history, physical examination and at least one of the following: hepatic ultrasound,computerised axial tomography (ct) scan, magnetic resonance imaging (mri), and/or liver biopsy * only for subjects with normal hepatic function: subjects who are judged to be in good general health based on physical examination, medical history, ecg, vital signs, and the results of biochemistry, coagulation, haematology tests and urinalysis performed during the screening visit, as judged by the investigator exclusion criteria: * female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential not using an adequate contraceptive method throughout the trial including the follow-up period (adequate contraceptive measures as required by local regulation or practice) * uncontrolled hypertension (defined as systolic blood pressure above or equal to 180 mmhg and/or diastolic blood pressure above or equal to 100 mmhg). if white-coat hypertension is suspected at the screening visit a repeated measurement at the screening visit is allowed * mental inability, unwillingness or language barrier precluding adequate understanding of or compliance with trial procedures * donation of any blood or plasma in the past month or in excess of 400 ml within the 3 months preceding screening, or surgery or trauma with more than 400 ml blood loss within the 3 months preceding screening