Kornimate/medical-research-clean huggingface dataset:
safety and pharmacokinetics of fg-3019 in adolescents and adults with focal segmental glomerulosclerosis (fsgs)

Conditions: Focal Segmental Glomerulosclerosis

Summary: the purpose of this study is to evaluate the safety and tolerability of fg-3019 administered over 8 weeks to adolescent and adult subjects with steroid-resistant focal segmental glomerulosclerosis (fsgs).


Eligibility criteria:
inclusion criteria: 1. age 12-64 years, inclusive, and girls age 10-11 years, inclusive if tanner stage 3 or greater 2. biopsy diagnosis of primary fsgs with biopsy confirmed centrally 3. age less than or equal to 2 years old at onset of proteinuria 4. first morning urine protein/creatinine ratio (u p/c) \>1 gm/gm 5. estimated glomerular filtration rate greater than or equal to 40 ml/min/1.73 m2 exclusion criteria: 1. non-fsgs renal disease other than benign cyst; or secondary fsgs 2. history of organ transplantation 3. history of allergic or anaphylactic reaction to human, humanized, chimeric or murine monoclonal antibodies 4. history of malignancy, cardiovascular disease, diabetes mellitus, sickle cell disease, multiple sclerosis, systemic lupus erythematosus, or active or recurrent serious infections (including but not limited to hepatitis b, hepatitis c, or hiv) 5. participation in studies of investigational drugs within 6 weeks prior to day 0 or receipt of an investigational drug within 12 weeks prior to day 0 6. aspartate aminotransferase (ast) or alanine aminotransferase (alt) \> 2.5 times the upper limit of normal 7. hematocrit \< 30%

Keywords: steroid resistant focal segmental glomerulosclerosis fsgs adolescent focal segmental glomerulosclerosis focal segmental glomerulosclerosis
comparison of calcium channel blockers and beta blockers on tourniquet-induced hypertension during intravenous regional anesthesia

Conditions: Hypertension

Summary: the investigators aimed to investigate the efficacy of calcium channel blockers and beta blockers for controlling tourniquet induced blood pressure increase in patients undergoing carpal tunnel operations with ivra. for this purpose files of patients undergoing operation under ivra were retrospectively examined in terms of demographical and hemodynamic variables.

after approval of the university research ethics committee, the files of patients who have been operated under intravenous regional anesthesia (ivra) in orthopedics clinics between january 2009 and january 2010 were retrospectively investigated. a total of 312 patients, 164 patients with carpal tunnel syndrome and 148 patients with trigger finger have been operated under ivra. out of 164 patients who have been operated due to carpal tunnel syndrome, 50 patients in which either calcium channel blockers or beta blockers were used for treatment of critical blood pressure increase after tourniquet inflation and in which whole data were obtained, were included to the study.the patients with systolic blood pressure above to 150 mmhg following tourniquet inflation and in which bolus dose of diltiazem 10 mg (group i) or calcium channel blocker 0.5mg/kg (group ii) have been administered by intravenous route constituted the study groups. demographical characteristics and hemodynamic parameters were recorded from the patient files.

Eligibility criteria:
inclusion criteria: patients operated due to carpal tunnel syndrome under intravenous regional anesthesia betweem january 2009 and january 2010. exclusion criteria: the patients that the files could not be reached

Keywords: intravenous regional anesthesia
immunomodulatory biomimetic device to treat myocardial stunning in end-stage renal disease patients

Conditions: End Stage Renal Disease; Acute Kidney Injury; Chronic Kidney Disease Stage 5

Summary: hemodialysis is a therapy that filters waste, removes extra fluid and balances electrolytes. in hemodialysis, blood is removed from the body and filtered through a man-made membrane called a dialyzer, and then the filtered blood is returned to the body. hemodialysis is associated with injury to the heart muscle called myocardial stunning. this may occur for many reasons, including removal of fluid during dialysis or low blood pressure. initial ischemia and subsequent white blood cell infiltration into the injured myocardium play a critical role in the degree of myocardial ischemia reperfusion injury. in this study an additional man made membrane (selective cytopheretic device) and tubing will be added to the dialysis circuit. the device shifts the circulating white blood cells pool to a less inflammatory phenotype. researchers believe the selective cytopheretic device will alter the phenotype of circulating white blood cells which play a role in myocardial stunning. the purpose of this study is to evaluate whether the selective cytopheretic device will reduce myocardial stunning events in hemodialysis patients. it will also report the rate of adverse events.


Eligibility criteria:
inclusion criteria: * end-stage renal disease (chronic kidney disease stage 5) * receiving hemodialysis 3 times/week for over 3 months * baseline blood pressure before hemodialysis has been ≥ 100/50 over preceding 4 weeks * recurrent weight gain between hemodialysis sessions exclusion criteria: * any active inflammatory condition (e.g., gout, systemic lupus erythematosus flare, hepatitis b or c infection, allograft rejection, subcutaneous injection of illicit drugs, "skin popping") * treatment with immunosuppressive therapy within 30 days of study * blood levels within a specified range * woman who is pregnant, breast feeding a child, or is trying to become pregnant * heart weakness or failure

Keywords: end stage renal disease hemodialysis chronic kidney disease stage 5
anal fistula plug, a retrospective study

Conditions: Healing Rate; Recurrence; Complication

Summary: in this study, we retrospectively reviewed clinical data of patients who were treated with an anal fistula plug for trans-sphincteric anal fistulas, and evaluated the long-term therapeutic effect of an anal fistula plug and the risk factors impacting anal fistula healing. in addition, we assessed the effects of post-operative changes on anal function, as well as the risk factors affecting anal function.

treatment of anal fistulas, especially involving signiﬁcant anal sphincters, continues to represent a challenge for surgeons. surgery has been the mainstay of treatment, and the ideal goal of anal fistula treatment is to obliterate the fistulous tract, while preserving the anal sphincter and avoiding fecal incontinence. the anal fistula plug is a sphincter-sparing procedure that uses biological substances to close an anorectal fistula. several studies have preliminarily shown that the anal fistula plug had advantages of simple and repeatable application, preservation of sphincter integrity, minimal patient discomfort, and subsequent surgical options if needed. the healing rate of anal fistula plug varied widely, which range from 14% to 88%, and no significant effect on anal function in the short term. therefore, long-term observation and a large sample size are needed to evaluate the long-term healing rate of an anal fistula plug, and the effect on anal function. the aim of this study is to assess the long-term therapeutic effect of an anal fistula plug in patients with trans-sphincteric fistula-in-ano, as well as the impact on anal function.

Eligibility criteria:
inclusion criteria: * patients with trans-sphincteric anal fistula. * the case information was complete. * not receive other treatment previously. exclusion criteria: * fistulas related to crohn's disease, ulcerative colitis or anorectal tumors. * underwent surgical incision and drainage for acute perianal infections within 3 months. * multiple fistula tracts \> 2. * poor underlying condition and unable to tolerate surgery.

Keywords: anal fistula plug trans-sphincteric anal fistula overall healing rate anal function risk factors minimally invasive
observational study of bis in hemodialysis patients

Conditions: Kidney Failure, Chronic; Renal Failure Chronic; Hemodialysis

Summary: this observational study will evaluate bioimpedance spectroscopy (bis) measurements from patients undergoing hemodialysis.

this observational study will evaluate bioimpedance spectroscopy (bis) measurements from patients undergoing hemodialysis. if changes in bis parameters correlate with changes in fluid volume and patient symptoms, bis may help provide a non-invasive way to estimate the amount of fluid to dialyze during a hemodialysis session. data from this study may be used to inform the design of a future interventional trial of bis use in hemodialysis patients.

Eligibility criteria:
inclusion criteria: 1. age \>=18 years of age; 2. end-stage renal disease with a gfr \<15 ml/min/1.73m\^2 and dialysis dependent requiring 3-times weekly dialysis; 3. able and willing to remove shoes and stand on sozo for bis measurements; 4. able to provide written informed consent and authorization to use and disclose health information. exclusion criteria: 1. is enrolled in a concurrent interventional study of an experimental treatment that may confound the results of this study, in the investigator's opinion; 2. has a clinical condition that would not allow them to complete the study; 3. is pregnant or planning to become pregnant; women of childbearing potential (or premenopausal) must be on 2 forms of contraception; 4. is lactating; 5. has an implanted cardiac rhythm management device (pacemaker or implantable cardioverter defibrillator); 6. has an amputation of a limb/s resulting in them being unable to make contact with the sozo electrodes (amputations of fingers and toes are not an exclusion); 7. patient determined by the attending physician unlikely to be compliant with study procedures.
a study evaluating the long-term safety of elexacaftor combination therapy

Conditions: Cystic Fibrosis

Summary: this study evaluate the long-term safety and tolerability of elexacaftor (elx)/tezacaftor (tez)/ ivacaftor (iva) triple combination (tc) in participants with cystic fibrosis (cf) who are homozygous for f508del.


Eligibility criteria:
key inclusion criteria: * completed study drug treatment in parent study (vx18-445-109); or had study drug interruption(s) in parent study but completed study visits up to the last scheduled visit of the treatment period in the parent study key exclusion criteria: * history of study drug intolerance in parent study other protocol defined inclusion/exclusion criteria may apply.
chronic hepatitis b and c recall northern holland

Conditions: Hepatitis B; Hepatitis C

Summary: the project aims to retrieve patients diagnosed with chronic hepatitis b (chb) and hepatitis c (chc) who are lost to follow-up.data files of the public health system and microbiology laboratories will be explored for registered cases of chb and chc. subsequently the investigators will compare the registered cases with the list of known chb and chc patients in hospital care. patients lost to follow up will be informed and approached via either the public health service (phs) or their primary care physician. identified patients will be invited for re-evaluation at the regional hepatitis centre (the north western hospital, formerly medical centre alkmaar) to assess the current status of their chronic disease. evaluation will be performed in accordance with (inter-)national guidelines, no extra interventions will be performed. after completion of re-evaluation, a final report will be made and send to both patient and primary care physician with recommendations for further follow-up.


Eligibility criteria:
inclusion criteria: * diagnosis of chronic hepatitis b (two positive hbsag measurements with an interval of 6 months) * diagnosis of chronic hepatitis c (two positive anti-hcv with an interval of 6 months) exclusion criteria: * already known in specialized care for chronic hbv or chronic hcv * cured from chronic hbv or chronic hcv

Keywords: recall study lost to follow-up
early treatment with dexamethasone in mild acute pancreatitis

Conditions: Patients With Acute Pancreatitis

Summary: this pilot trial will evaluate the following in patients with acute pancreatitis: 1. safety profile of early treatment with intravenous dexamethasone 2. impact of dexamethasone on systemic inflammation in patients with acute pancreatitis 3. provide preliminary data on potential impact of early treatment with steroids on clinical outcomes


Eligibility criteria:
inclusion criteria: * age\>=18 years * diagnosis of acute pancreatitis confirmed by at least 2 of the following: 1. typical epigastric abdominal pain 2. elevation amylase/lipase \>3 times upper limit normal and/or 3. confirmatory findings on cross-sectional imaging * enrollment within 8 hours of presentation exclusion criteria: * class ii or greater nyha heart failure * oxygen dependent copd * chronic kidney disease\>stage 2 * cirrhosis * existing necrosis on abdominal ct * organ dysfunction prior to enrollment * sepsis * acute respiratory distress syndrome * malignancy not in remission for at least 5 years * active drug use * known allergy to dexamethasone * altered mental status * insulin-requiring diabetes * abdominal surgery within 60 days
the efficacy of combination of traditional tibetan and remote ischemic conditioning on high altitude polycythemia

Conditions: High Altitude Polycythemia

Summary: a multicenter, randomized controlled trial was designed to evaluate the effectiveness and safety of the comprehensive traditional tibetan medicine program combined with remote ischemic conditioning on high altitude polycythemia.


Eligibility criteria:
inclusion criteria: * patients with high-altitude polycythemia aging 18 to 65 years. exclusion criteria: * allergic to tibetan medicine ingredients; * inappropriate to receive tibetan medicine treatment and/or remote ischemic conditioning.
comparison of data obtained by echocardiography and magnetic resonance imaging in hypertrophic cardiomyopathy

Conditions: Hypertrophic Cardiomyopathy

Summary: compare data (structural and functional) obtained by transthoracic rest echocardiography and magnetic resonance imaging (with gadolinium) in 30 patients with hypertrophic cardiomyopathy

all data from consecutive patients with hcm explored by 2d-echo or mri in our institution will be analyzed blindly by a senior echocardiographist and a senior radiologist to highlights the respective interest of each of these examinations for the detection of structural or functional abnormalities in hcm.

Eligibility criteria:
inclusion criteria: * hypertrophic cardiomyopathy * age \> 18 years exclusion criteria: * pregnancy * pacemaker * iacd * allergy to gadolinium * secondary hypertrophy

Keywords: hypertrophic cardiomyopathy echocardiography magnetic resonance imaging
therapeutic innovation in type 2 diabetes (it-diab)

Conditions: Pre-diabetes

Summary: the main objective of the study is to follow prospectively a cohort of patients with pre-diabetes to understand the pathophysiological mechanisms involved in switching from pre-diabetes to type 2 diabetes and to identify new biomarkers of type 2 diabetes risk in this population.


Eligibility criteria:
inclusion criteria: * adult patients (≥18 years) * subjects with diabetes risk score ≥ 15 * subjects with impaired fasting glucose: blood glucose ≥ 1.10 g/l and \< 1 .26 g/l * subjects affiliated with an appropriate social security system exclusion criteria: * fasting glycemia ≥ 1.26 g/l * fasting glycemia ≤ 1.10 g/l * subjects previously treated with oral anti-diabetic: metformin, glitazones, inhibitors of α-glucosidase, sulfonylurea, repaglinide, inhibitors of dpp-iv, glp-1 r agonists. * subjects previously treated with insulin, except gestational diabetes * severe coagulation disorders * thrombocytopenia \< 100 000/mm 3 * severe psychiatric disorders * severe renal insufficiency (creatinine clearance \< 30 ml/min) * severe hepatic insufficiency (tp \< 50%) * alcohol abuse (\> 30g/j) * patient's opposition * subject unable to follow the study during the 5 years of follow-up * subject exclusion period in a previous study

Keywords: pre-diabetes type 2 diabetes biomarkers cohort diabetes risk score
utilizing 3d imaging for burn wound assessment

Conditions: Burn; 2nd Degree Burn of the Skin; 3rd Degree Burn of the Skin; 1st Degree Burn of the Skin

Summary: the goal of this prospective cohort study is to determine if the dermamonitor camera can accurately determine burn size in patients with 1st, 2nd, or 3rd degree burns, with exploratory aim of testing a new artificial intelligence (ai) program for determining burn depth. the main aims are: 1. the primary aim of this study is to assess an objective process for the classification of burn size using the dermamonitor wound camera. 2. an exploratory aim of this study is to begin to train an artificial intelligence (ai) program to classify burn depth (1st, 2nd, 3rd degree) using the 3d images from this novel wound camera. researchers will compare dermamonitor size classification and ai depth classification to clinician determinations. participants will have images taken of their burn. participation ends when the images are taken.


Eligibility criteria:
inclusion criteria: * adults sustaining burns * outpatients * no prior surgery on the wounds * no known infection of the wounds exclusion criteria: * burns to the face or sensitive areas (genitals) * burns located on or near identifying landmarks such as tattoos or birthmarks * non-english speaking patients * patients unable to sign their name * burn occurred greater than 7 days prior to clinic visit * age greater than 90 (patient age is sent externally to iko, to ensure no phi is sent, patients with an age \>90 will not be enrolled)

Keywords: 3d imaging ai
exploring the impact of " acp board game for life" on death preparation and anxiety in patients with stage 4 and 5 chronic kidney diseases: a pilot study

Conditions: Chronic Kidney Disease; Chronic Renal Failure; Chronic Renal Insufficiency; End of Life Care; Advance Care Planning; Death Anxiety

Summary: this study was to explore the impacts of participating in "acp board game for life" on death preparation, death anxiety, end-of-life care preferences, and intervention perception in stage 4-5 ckd patients with advanced chronic kidney diseases in a medical center.

this study was to explore the impacts of participating in "acp board game for life" on death preparation, death anxiety, end-of-life care preferences, and intervention perception in stage 4-5 ckd patients with advanced chronic kidney diseases in a medical center. a nonrandomized two-arm pretest and posttest quasi-experimental design was used. patients in the control group received routine care while patients in the experimental group received routine care and acp board game for life. the acp board game, death preparation subscale, chinese likert death anxiety scale, self-created questionnaires and brief interview were used for data collection.

Eligibility criteria:
inclusion criteria: * stage 4-5 chronic kidney disease patients * chinese nationality * over 20 years old * consciousness clear, can communicate and express their opinions in mandarin and taiwanese exclusion criteria: * patients express that talking about death makes them feel scared or cause anxiety * the doctor assesses that the patient's condition is in the stage of septic shock, hemodynamic instability, asthma, pulmonary edema, hypoxemia or acute myocardial infarction * patients with contact or airborne precautions * patients without legal capacity

Keywords: chronic kidney disease death preparation death anxiety advance care planning board game
valsalva maneuver in thyroidectomy

Conditions: The Role of Valsalva Manoeuvre, in Thyroidectomy to Reduce Postoperative Bleeding

Summary: bleeding after total thyroidectomy remains a rare event that affects early postoperative morbidity, occurring in 0.3% up to 4.2% of cases. intraoperative bleeding is an unpleasant complication, and it is often easily manageable though postoperative bleeding may represent a life-threatening condition for the patient. between january 2019 to february 2022 , 250 consecutive patients were listed for thyroidectomy. the investigators selected 178 patients and divided them in two groups based on the execution of the valsalva manoeuvre. the purpose of the investigator is to clarify whether the routine intraoperative execution of a valsalva manoeuvre (vm) may affect the detection of bleeding that would otherwise remain occult and therefore may manifest in the postoperative period.


Eligibility criteria:
inclusion criteria: * thyroid diseases exclusion criteria: * lymph node dissection * minimally invasive approaches * high anesthesiological risk
risk of fatigue in adolescent and young adult hodgkin lymphoma patients

Conditions: Fatigue; Hodgkin Lymphoma

Summary: fatigue is one of the most prevalent symptoms endorsed by cancer survivors, particularly those treated for breast cancer or hodgkin lymphoma. despite the tremendous implications such work has for effective interventions, little is known about the underlying pathophysiology of fatigue, association with medical co-morbidities and factors that may help predict those to be at highest risk. the proposed research will utilize vanderbilt-ingram cancer center reach for survivorship program together with the investigators hematologic malignancies program. in adolescent and young adults (aya), ages 18 - 39 the investigators will address the following: primary aims aim 1: assess the prevalence and severity of fatigue and its impact on functional outcomes aim 2: determine host, disease and treatment-related risk factors for fatigue secondary aims aim 1: evaluate the association between levels of proinflammatory cytokine activity and fatigue aim 2: evaluate the association between fatigue and self reported fatigue in aya hodgkin lymphoma (hl) survivors. hypotheses: 1. fatigue is more prevalent and severe among aya hl patients and survivors, compared to general population and will be associated with impaired functional outcome. 2. risk factors for fatigue include higher disease stage, b symptoms and elevated erythrocyte sedimentation rate at diagnosis, dose density of chemotherapy and higher doses and more expanded fields of radiotherapy. 3. risk of fatigue is associated with long-term cardiopulmonary and endocrine complications. 4. levels of specified proinflammatory cytokines are associated with increased fatigue.


Eligibility criteria:
inclusion criteria: * currently 18 years of age or older * alive without evidence of recurrent disease * must be off therapy (not on active treatment for hl or other malignancies) * must not be on any form of chemotherapy (oral or intravenous \[iv\]) * provide informed consent * can read and understand english * treated with risk-adapted therapy which may include radiotherapy doses \< 30 gy exclusion criteria: * evidence of a subsequent malignancy following lymphoma treatment

Keywords: hodgkin lymphoma survivors adolescent and young adults
pediatric hip plate versus cannulated screw in pediatric femoral neck fracture

Conditions: Femoral Neck Fractures

Summary: the purpose of this study is to compare the early postoperative radiologic and clinical outcomes of pediatric hip plate and cannulated screw fixation in pediatric femoral neck fracture (delbet type ii and delbet type iii).

the children aged 3 to 14 years with femoral neck fracture that were treated with pediatric hip plate and cannulated screw fixation.

Eligibility criteria:
inclusion criteria: * patients with fractures that met these criteria, underwent definitive surgery and had complete clinical and radiographic follow up until fracture union at either institution were included in this study. exclusion criteria: * pathologic fractures, and fractures in patients with osteogenesis imperfecta, neuromuscular disorders or any systemic disease that was associated with a predisposition to fractures or altered fracture healing were excluded.