Kornimate/medical-research-clean huggingface dataset:
spondyloarthritis and nutrition

Conditions: Spondyloarthrosis; Nutrition Disorders

Summary: the food composition and consumption of certain foods could be associated with a higher or lower inflammatory activity of spondyloarthritis and consequently changes in the quality of life of patients. this has been shown in other chronic inflammatory disease. in order to highlight a profile or nutritional profiles associated with the activity of the disease, we chose to carry out observational pilot study using a qualitative food survey, which will be submitted to all patients with spondyloarthritis. the general demographic data and the data of the disease will be collected by the investigating physician at the same time, as well as possible confounding factors: comorbidities, physical activity, treatments.


Eligibility criteria:
inclusion criteria: * patients over the age of 18 who meet the asas criteria for axial or peripheral spondyloarthritis * patients agreeing to participate and not objecting to the use of their personal data exclusion criteria: * presence of inflammatory bowel disease: crohn's or rch diagnosed * history of bariatric surgery * patient subject to a court order, guardianship or trusteeship * patient unable to complete questionnaire

Keywords: spondyloarthrosis nutrition disorders
kinesio taping effects on balance and ankle proprioception

Conditions: Ankle Injuries; Balanced

Summary: ankle injuries are among the most common musculoskeletal injuries, affecting both athletes and the general population. various methods are used to prevent such injuries, but the effectiveness of different kinesio taping applications on joint position sense and balance remains unclear. this study aims to investigate the effects of different kinesio taping techniques on proprioception and postural stability in healthy young adults. by identifying changes in balance and proprioception before injuries occur, the findings may provide clinical insights into the potential role of kinesio taping in rehabilitation and injury prevention.

ankle and foot injuries are among the most frequently observed musculoskeletal injuries, particularly in athletes and physically active individuals. various preventive methods have been developed to reduce the risk of such injuries, including exercise programs, footwear modifications, and taping techniques. kinesio taping (kt) is widely used to enhance proprioception, joint stability, and neuromuscular function, but its effectiveness in healthy young adults remains unclear. this study aims to evaluate the impact of different kinesio taping applications on joint position sense and balance in healthy young adults. the ankle-foot complex is rich in mechanoreceptors and plays a crucial role in movement and postural control. however, proprioceptive deficits and balance impairments contribute to the risk of injuries such as chronic ankle instability (cai) and lateral ankle sprains. while several studies have investigated the effects of kt in injured populations, research on its impact on proprioception and balance in uninjured individuals is lacking. by analyzing changes in balance and proprioception among healthy participants, this study will provide valuable insights into the potential role of kinesio taping in injury prevention. understanding these effects before an injury occurs could help refine rehabilitation strategies and improve clinical decision-making regarding the use of kinesio taping for both prevention and post-injury treatment.

Eligibility criteria:
inclusion criteria: * age: participants must be between 18-25 years old. * general health: participants must be generally healthy individuals, with no previously diagnosed chronic health conditions, musculoskeletal disorders, or history of injuries. * ankle health: no ankle injuries or surgical interventions in the past six months. * informed consent: participants must voluntarily agree to participate and sign the informed consent form. exclusion criteria: * history of injuries: any lower extremity injury (ankle or knee) within the past year. * neurological disorders: any neurological condition that may affect balance or proprioception. * other health conditions: presence of chronic diseases such as rheumatic diseases, diabetes, or musculoskeletal disorders that could impact the study outcomes.
does neuromuscular electrical stimulation benefit the functional ability of elderly patients with chronic obstructive lung disease

Conditions: Pulmonary Rehabilitation; Chronic Obstructive Lung Disease; Neuromuscular Electrical Stimulation; Pulmonary Function (FEV1/FVC)

Summary: background: patients with copd often experience skeletal muscle dysfunction. for those who are unable or unwilling to undertake physical training, neuromuscular electrical stimulation (nmes) may provide an alternative method of exercise training. objective: to investigate the effects of adding neuromuscular electrical stimulation of gluteus maximus, quadriceps and calf muscles to chest physiotherapy, compared to chest physiotherapy alone, on muscles strength (gluteus max., quadriceps, calf muscles), femoral blood flow physical and pulmonary function in severe copd patients.

material and methods: this study include a group of 60 patients (30 males and 30 females) diagnosed with severe copd), their age is ranged 65-75 years, they will be randomly divided into two groups; study group (a) 30 patients and study group (b) 30 patients. study group (a): the patients in this group will receive the chest physiotherapy program for 20 min each day, for five days a week for three consecutive weeks. study group (b): the patients in this group will receive the same chest physiotherapy program combined with neuromuscular electrical stimulation of gluteus max., quadriceps, calf muscles, performed for 30 min /day for five days a week for three consecutive weeks. femoral blood flow, gluteus maximus, quadriceps and calf muscles strength and pulmonary function (fev1/fvc) will be measured for both groups pre and post treatment.

Eligibility criteria:
inclusion criteria: * a diagnosis of copd with fev1/fvc \<50% predicted as per the gold guidelines. * self-reported dyspnea and/or arm fatigue during at least one activity of daily living that required arm exercise. * dyspnea and/or physical activity fatigue were self-reported by the borg scale. * before entering in the study, all patients had their pulmonary function optimized with long-acting bronchodilators and corticosteroids. exclusion criteria: * • patients with unstable angina pectoris. * progressive ventricular dysrhythmia. * intermittent claudication. * implanted cardiac pacemakers. * uncontrolled diabetes mellitus. * peripheral vascular disease.
randomized clinical trial pulvab (prophylactic pulmonary veins ablation)

Conditions: Arrhythmias, Cardiac; Cardiovascular Diseases; Postoperative Atrial Fibrillation; Myocardial Ischemia

Summary: to compare prophylactic strategies of atrial fibrillation in patients with cad and without af.

prospective, multicenter, randomized trial, intended to compare three prophylactic strategies of atrial fibrillation in patients with coronary artery disease and without history of atrial fibrillation. the study includes 4 groups of patients: group i (conventional cabg) group ii (cabg + pulmonary veins isolation). concomitant cabg and epicardial bipolar radiofrequency pulmonary veins isolation. group iii (cabg+ pulmonary veins isolation + amiodarone). concomitant cabg and epicardial bipolar radiofrequency pulmonary veins ablation with administration of amiodarone in postoperative periode. group iv (cabg+ amiodarone). conventional cabg with administration of amiodarone in postoperative periode.

Eligibility criteria:
inclusion criteria: * patients must have signed an informed consent. * patients had indications for two or more coronary arteries to be bypassed * no history of af exclusion criteria: * acute coronary syndrome * previous cabg. * a significant decrease in the contractile function of the heart (ef \<40%) * significant heart valve disease requiring surgical repair * long-standing persistent, persistent, or paroxysmal forms of atrial fibrillation * respiratory failure * left ventricular aneurysm requiring surgical correction * chronic renal failure (≤60 ml/min/1⋅73 m2) * chronic diseases that make a significant contribution to the prognosis of life (e.g. oncology) * participation in other clinical trials

Keywords: bipolar radiofrequency ablation atrial fibrillation new onset cabg coronary artery disease postoperative atrial fibrillation
study of human sensory perception

Conditions: Epilepsy

Summary: this study will help describe how the human brain works when a person sees something, hears something, learns something, or thinks about something by recording brain activity that occurs when the person does a series of computer tasks. this study will be offered to people who are in the hospital to be monitored for epilepsy by using electrodes placed in the brain. the study will record brain activity that occurs when a patient does a memory task, for example.

patients who have elected to have invasive electrophysiological monitoring for epileptic activity are invited to participate in this study. while the electrodes are in place, patients are asked to view several scenarios on a laptop computer. during these scenarios, for example, patients are asked to click a mouse button if they see the same picture twice in a row or to remember a film clip of a scooter ride. trigger points in the computer scenarios are recorded on a separate channel alongside the brain-wave activity to allow correlation between the brain activity and the task requested in the scenario. using this technique, researchers can determine what areas of the brain were active during recognition or recall activities.

Eligibility criteria:
inclusion criteria: * primary diagnosis of epilepsy * between 10 and 65 years of age * scheduled to undergo invasive electrophysiological monitoring as part of a clinical evaluation for epilepsy treatment exclusion criteria: * none

Keywords: epilepsy invasive monitoring human sensory perception
evaluation of different perimetric grids to detect central visual field defect in glaucoma patients with reduce ganglion cell layer thickness measured by spectral domain oct.

Conditions: Glaucoma

Summary: the aim of the study is to evaluate the agreement between three different grids in detecting central visual field defect in early glaucoma patients with reduced ganglion cell layer thickness.


Eligibility criteria:
inclusion criteria: * glaucoma patients with glaucomatous optic nerve head defect and reduced ganglion cell layer thickness exclusion criteria: * age\<18 years * unable to read, understand and sign the written informed consent * unable to perform visual field test * advanced glaucoma with c/d\>0.7 * other causes of optic neuropathies * retinal or macular diseases * lens or corneal opacities * spherical refractive defect \>± 6d * cylindric refractive defect \>± 3d
immunogenicity and safety of the yellow fever vaccine in hiv infected individuals

Conditions: HIV Infections

Summary: phase 4 study to evaluate the immunogenicity and safety of the 17dd yellow fever vaccine in hiv infected individuals, compared to non-hiv-infected individuals. main objective: to compare the proportion of seroconversion and the geometric mean of neutralizing antibodies 30 days and 365 days after vaccine. secondary objectives: to evaluate whether the titles of neutralizing antibodies are associated with cd4 lymphocyte counts, cd8 lymphocyte counts, cd4 nadir, hiv viral load and use of antiretroviral therapy. to assess the yellow fever vaccine viremia at day 10 after vaccine.to compare the incidence of adverse events in hiv-infected and non-hiv-infected individuals.


Eligibility criteria:
inclusion criteria: * hiv infected adults, age \>= 18 and \<60 years old. * cd4 \> 200 cells/mm³ within the last 6 months prior to inclusion. individuals with no cd4 results in the last 6 months which have undetectable hiv viral load and last cd4 count \> 350 can be included. * healthy hiv-uninfected individuals (aged \>= 18 and \< 60) * no history of yellow fever vaccination * willing to participate and to sign the consent exclusion criteria: * individuals with chronic diseases such as: decompensated diabetes, kidney failure (in dialysis), liver failure/cirrhosis, cancer (except for non-melanoma skin cancer and in situ hiv related carcinoma), use of immunosuppressive agents (including prednisone ≥ 20mg/day, during 7 or more days in the last 30 days before inclusion). * pregnant women * hypersensitivity reaction to eggs, chicken protein. allergy to erythomycin or kanamycin. hereditary fructose intolerance. * administration of immunoglobulins or blood derivates \< 3 months or life attenuated vaccine \<1 month. * history of thymic dysfunction (including thymoma and thymectomy). * use of anti-ccr5 * symptoms of severe acute illnesses or fever (axillary temperature ≥ 38°c) * hiv positive rapid test for hiv negative subjects.

Keywords: yellow fever vaccine hiv
value of ondansetron medication vs inhaled isopropyl therapy in the emergency department (vomiited)

Conditions: Nausea; Vomiting

Summary: this study will compare two different ways to relieve nausea and vomiting in the emergency department. the usual treatment for nausea/vomiting is a drug called zofran, but new studies have suggested that smelling alcohol pads can also help to relieve nausea and vomiting.

emergency physicians commonly use medications to alleviate nausea and vomiting. the medication ondansetron is used in the emergency department and after surgery for this purpose. inhaled isopropyl alcohol has been successfully used to decrease nausea and vomiting after surgery. no trial has compared inhaled isopropyl alcohol to ondansetron in a clinical trial. the author proposes to prospectively investigate extension of the established antiemetic efficacy of inhaled isopropyl alcohol for undifferentiated nausea in emergency department patients to the 30-minute post-intervention point that has been reported to be the frequent juncture of symptom relief. by introducing prolonged intervention, and re-dosing of established benefit, into this research, the author aims to reproduce the sustained antiemetic efficacy of inhaled isopropyl alcohol for undifferentiated nausea as demonstrated for post-operative nausea and vomiting.

Eligibility criteria:
inclusion criteria: * patients aged 18-65 years presenting to the emergency department complaining of current nausea with or without episodes of emesis beginning within the previous 24hrs exclusion criteria: * patients with known allergy to isopropyl alcohol * patients outside of the defined age range * patients with an inability to inhale through the nares (including recent upper respiratory infection) * patients greater than 20 weeks estimated gestation * patients with past medical history of gastroparesis, or hemoptysis * patients who have taken an antiemetic medication in the past 48 hours * patients demonstrating hemodynamic instability with systolic blood pressure \ 120 bpm

Keywords: isopropyl alcohol zofran antiemetics
this study aims to evaluate the effect of rinsing off or blot-drying silver fluoride on the retention of subsequently-applied resin- and glass ionomer-based fissure sealants in permanent molars affected by molar-incisor hypomineralization.

Conditions: Molar Incisor Hypomineralisation; Children; Dental Caries

Summary: the aim of this study is three-fold: 1. to evaluate the clinical performance of glass ionomer fissure sealants and resin fissure sealants when placed immediately after or one week following the application of silver fluoride on permanent molars affected by molar-incisor hypomineralization in high caries-risk children. 2. to compare the effects of rinsing off the silver fluoride or not rinsing it off (blot-drying with cotton pellet) on sealant retention when the sealant is placed immediately after silver fluoride application, and 3. to measure the desensitizing effect of fissure sealant application following silver fluoride treatment on hypersensitive mih molars.

teeth will be randomized in a parallel design based on the application of restoration time (immediate or one week later), sealant material type (resin or glass ionomer), and for immediate applications, the condition of silver fluoride before restoration (dried with cotton or rinsed gently). a total of 216 permanent molars will be included in the study. randomization of molar teeth into six groups according to the restoration time, dental restorative material type, and conditions:

Eligibility criteria:
inclusion criteria: * patients and their parents who consent to participate and have signed the informed consent form. * patients with at least one permanent molar diagnosed with molar incisor hypomineralization based on eapd guidelines. * fully erupted teeth with icdas i or ii lesions that necessitate the application of fissure sealants. * teeth displaying demarcated opacities on the occlusal surface and at least one additional surface. exclusion criteria: * teeth that have existing restorations or cavities. * patients currently receiving orthodontic treatment. * patients who are uncooperative during dental procedures. * teeth affected by dental fluorosis or enamel defects associated with specific syndromes. * children with systemic conditions requiring ongoing medication.

Keywords: molar incisor hypomineralisation children silver fluoride fissure sealant glass ionomer silver-modified atraumatic restorative treatment
serratus anterior plane (sap) block vs sap block combined with transverus thoracic plane (ttp) block, for post-mastectomy pain control.

Conditions: Pain, Postoperative

Summary: a comparison shall be conducted between serratus anterior plane block, on one hand, and transversus thoracic plane block combined with serratus anterior plane block, on the other hand for management of post-mastectomy pain. vas "visual analogue scale" score will be compared in both case, and control groups.

breast cancer is one of the most common cancers in women all over the world. in the united states, according to the cdc "center of disease control", it's the second most common cancer occurring in women. perioperative pain after breast surgeries remains to be taken lightly due to the minimal invasiveness of breast surgeries. however, it is estimated that 25-60% of patients undergoing breast cancer related surgeries develop chronic pain. acute post-operative pain remains an important risk factor in developing chronic post-mastectomy pain; about 40% of women will have acute post-operative pain, on the other hand, 50% will have chronic pain. different regional anaesthesia techniques have achieved better management of post-breast surgery acute pain and subsequently less frequent chronic pain. add to that, effective regional anaesthesia will decrease both the surgical stress response and the requirements of general anaesthetics and opioids, which will keep the function of the immune system intact. a lot of regional anaesthesia techniques have been used to control anterior chest wall pain as the pectoral nerves (pecs) block, paravertebral block, intercostal nerve blocks, thoracic epidural analgesia, serratus anterior plane block. the breast receives its innervation through the anterior and lateral cutaneous branches of the 2nd to the 6th intercostal nerves. targeting the serratus plane is a safer and a simpler procedure than multiple intercostal or paravertebral blocks. as a setback for the serratus anterior plane block, it only blocks the lateral cutaneous branches of the intercostal nerves with minimal if any effect on the anterior cutaneous branches. the serratus anterior plane block, being unable to block the anterior cutaneous branches of the intercostal nerves, have to be combined with another technique, transversus thoracic plane block, which can block them. the investigators here are trying to measure the efficacy of the combined serratus anterior plane block and tranversus thoracic plane block on the management of post-mastectomy pain.

Eligibility criteria:
inclusion criteria: * adult female patients \> 30 years old, asa "american society of anaesthesiologists" physical status i or ii undergoing any unilateral mastectomy. exclusion criteria: * patient's refusal. * known contraindications to regional blocks, including local skin infections,and coagulopathy. * allergies to the local anaesthetics used.

Keywords: serratus anterior plane block transversus thoracic plane block post-mastectomy pain
pivotal clinical study to assess the anti-adhesive effect and safety of abt13107 applied to postoperative intrauterine

Conditions: Postoperative Adhesion of Uterus

Summary: this study is intended to evaluate the efficacy and safety of abt13107 compared to hyalobarrier applied to postoperative intrauterine.


Eligibility criteria:
inclusion criteria: * female patients aged from 19 to 70 * those who are scheduled for hysteroscopy to treat the following diseases: submucosal myomas, endometrial polyps, intrauterine adhesion etc. exclusion criteria: * those who will apply other intrauterine device rather than investigational device during the study period.
prediction of hemodynamic response to intubation by ani variation during standardized stimulation

Conditions: Tracheal Intubation Morbidity; Pain

Summary: the objective : to investigate a correlation between ani following a standardized nociceptive stimulus and hemodynamic or somatic reactions during orotracheal intubation. piloted study. ani and hemodynamic and somatic parameters response associated tetanus stimulation followed by orotracheal intubation were collected.

background: the analgesia nociception index reflects the balance between analgesia and nociception and allows early detection of a defect in analgesia. orotracheal intubation is responsible for a sometimes deleterious hemodynamic reaction. the analgesia nociception index could allow an individual adjustment of the investigator's anesthetic inductions during this period. objective: the objective of this study is to investigate if there is a correlation between variations in the ani following a standardized nociceptive stimulus and the occurrence of hemodynamic or somatic reactions during orotracheal intubation without muscle relaxation. materials and methods: prospective, interventional, analytical, monocentric, piloted study carried out in the operating theatre after obtaining patient's informed consent between january 2014 and november 2014. under steady state total intravenous anaesthesia with propofol and remifentanil at constant dosage (entropy between 40 and 60) tetanus stimulation of the ulnar nerve was performed followed by orotracheal intubation. the variation of ani and hemodynamic parameters as well as the somatic response associated with both maneuvers were collected.

Eligibility criteria:
inclusion criteria: * any patient requiring general anaesthesia with tracheal intubation by direct laryngoscopy * intubation difficulty assessment score \< 7 * bmi between 17 and 30 kg/m2 * socially insured patient * patient 18 years of age or older * patient with signed consent * patient with a sinus heart rhythm exclusion criteria: * patient refusing to participate in the study * pregnant woman * patient with a pace maker (any mode) * patient treated with beta blocker * known dysautonomia * diabetes * spontaneous ventilation anaesthesia * allergy to any of the required medications

Keywords: ani hemodynamic responses tracheal intubation