Kornimate/medical-research-clean huggingface dataset:
bivalirudin pci registry in heparin induced thrombocytopenia/heparin induced thrombocytopenia and thrombosis syndrome (hit/hitts) patients

Conditions: Heparin-Induced Thrombocytopenia; Heparin-induced Thrombocytopenia and Thrombosis Syndrome

Summary: to monitor the frequency of the development of thrombocytopenia in patients with heparin induced thrombocytopenia/heparin induced thrombocytopenia and thrombosis syndrome receiving bivalirudin during percutaneous coronary intervention


Eligibility criteria:
inclusion criteria: * clinically documented history of hit/hitts * suspicion of hit/hitts exclusion criteria: * bleeding diathesis * ischemic stroke * chronic thrombocytopenia * hematologic malignancy * contraindication to bivalirudin * pregnant or nursing mothers

Keywords: hit hitts
utilizing of physiological parameters predict the prognosis of cirrhotic patients with gastrointestinal bleeding

Conditions: Liver Cirrhosis; Gastrointestinal Bleeding

Summary: can physiological indicators such as quick sequential organ failure assessment , shock index, and its derived indicators such as modified shock index , age shock index and respiratory adjusted shock index accurately predict the prognosis of cirrhosis patients with gastrointestinal bleeding? to explore the improvement of emergency and critical care patient management.

cirrhosis is a common chronic liver disease with gastrointestinal bleeding being one of its complications. gastrointestinal bleeding is quite common in patients with cirrhosis, but its prognosis is difficult to accurately predict. in current clinical practice, critical care physicians often use physiological indicators to assess the risk level of patients. among them, the shock index and its derived indicators such as the modified shock index, age shock index, and respiratory adjusted shock index have been widely used in other fields, but their actual value in patients with cirrhosis complicated by gastrointestinal bleeding is not yet clear. the prognosis of cirrhosis patients with gastrointestinal bleeding affects the quality of life and survival of the patients, thus necessitating the establishment of a reliable prognostic assessment tool to assist critical care physicians in making rapid treatment decisions. the motivation of this study is to explore the application value of shock index-related indicators in predicting the prognosis of cirrhosis patients with gastrointestinal bleeding, in order to improve the medical efficiency for this specific group of critically ill patients.

Eligibility criteria:
inclusion criteria: cirrhosis with gastrointestinal bleeding - exclusion criteria: no complete medical record and trauma patient -

Keywords: cirrhosis gastrointestinal bleeding physical indicator shock index
coronary artery disease and exercise adherence

Conditions: Adherence, Treatment; Coronary Artery Disease

Summary: this study aims to determine the factors affecting exercise adherence in patients with coronary artery disease (cad). for this purpose, the following measurement tools will be used respectively: (1) "patient information form" including sociodemographic characteristics of the patients and medical information related to the disease, (2) the exercise adherence rating scale (ears), (3) exercise self-efficacy scale (ese) and, (4) turkish-health literacy survey europe-q12 (hls-eu-19-12q-tr). statistical analyses will be carried out by descriptive statistics (number, percentage, mean, standard deviation, etc.), correlation analysis and regression analysis.

coronary artery disease (cad) is the most common form of cardiovascular disease in the world and is one of the leading causes of mortality and morbidity in turkey and worldwide. exercise training is very important in the treatment of cad because of its various cardiovascular benefits. however, most patients have been shown to have low to moderate adherence rates to the recommended exercise prescription. the results of a limited number of studies show that the factors affecting exercise adherence in patients with cad need to be supported by new studies. this study aims to determine the factors affecting exercise adherence in patients with coronary artery disease (cad). the study will be conducted with cad patients followed up in the cardiology clinics of a tertiary care hospital in northern turkey. a cohen's d will be calculated using preliminary data from 20 patients using exercise adherence rating scale (ears), and an adequate sample size will be determined with a 95% confidence interval, a bias level of 0.05, and 80% power. patients with a diagnosis of cad confirmed by a physician at least one year ago, who have been recommended any exercise/physical activity by a physician according to article 1 of ears, who are ≥18 years old and \<75 years old, and who have the ability to understand and speak turkish will be included in the study. the data will be collected using the following measurement tools respectively: (1) "patient information form" including sociodemographic characteristics of the patients and medical information related to the disease, (2) the exercise adherence rating scale (ears), (3) exercise self-efficacy scale (ese) and, (4) turkish-health literacy survey europe-q12 (hls-eu-19-12q-tr). statistical analyses will be carried out by descriptive statistics (number, percentage, mean, standard deviation, etc.), correlation analysis and regression analysis.

Eligibility criteria:
inclusion criteria: * a diagnosis of cad confirmed by a physician at least one year ago, * individuals who have been recommended any exercise/physical activity by a physician according to item 1 of the ears, * turkish comprehension and speaking skills. exclusion criteria: * presence of serious physical and mental health problems,

Keywords: exercise adherence coronary artery disease self-efficacy health literacy
preoperative shielding and n/t rt-pcr swabbing for elective cancer surgery

Conditions: Covid19; Cancer

Summary: trial to assess the effectiveness of pre-operative screening for covid-19 in patients undergoing elective cancer surgery.

1. background: the optimal method of screening patients for covid infection before elective cancer surgery is unclear. provisional data from the international covidsurg audit as well as a similar study from china has shown mortality rates of in excess of 20% for covid +ve patients undergoing surgery and so ensuring patients do not have infection before surgery is critical (1). current practice for the preoperative screening of elective surgical patients involves a period of self-isolation, assessment of self-reported symptoms and nose and throat swab testing. many patients are asymptomatic with covid and the false negative rate of rt-pcr nose and throat swabs may be as high as 30% (2,3). furthermore, we do not know how effective our strategy is at preventing hospital acquired covid in the days after surgery. patients are currently going to designated clean (silver) wards postoperatively to reduce this risk with other patient who have tested negatively to the above screening process too 2. rationale: the aim of this study is to assess the rate of perioperative covid in elective surgical patients, and to assess whether rt-pcr swabbing adds any additional value i.e. does it detect clinically important asymptomatic patients. if asymptomatic patients are diagnosed preoperatively this will reduce perioperative morbidity and mortality as well as confirming this as an appropriate preoperative screening process. alternatively, should nose and throat swabbing not improve the diagnosis of covid-19 in asymptomatic patients this trial may stop unnecessary visit to the hospital where they may be more likely to contract covid-19 and reduce the use of a limited resource.

Eligibility criteria:
inclusion criteria: * participants capable of giving informed consent, * gender: male and female * age: 18 years and above * preoperative cancer patients (elective) * willing to be contacted by phone after hospital discharge * patients listed for inpatient admission postoperatively (cancer patients) exclusion criteria: * cancer patients who require non-cancer surgery * emergency cancer operations * patients under the age of 18 * patients who do not have capacity to consent * cancer patients not requiring an inpatient stay postoperatively * patients who it was not anticipated would require an inpatient stay preoperatively but required admission after surgery
this research project studies the relationship between osa and nocturia.

Conditions: Obstructive Sleep Apnea

Summary: the main goal of the study is to explore the relationship between obstructive sleep apnoea and nocturia.

the observation study will be performed on patients diagnosed with obstructive sleep apnoea. patients will undergo routine examination for sleep apnoea and will be asked to fill in voiding diaries for 48 hours. the main goal of the study is to find whether there are any parameters of sleep apnoea associated with occurrence of the nocturia.

Eligibility criteria:
inclusion criteria: * patients diagnosed obstructive sleep apnoea (osa ) * apnea-hypopnea index (ahi) \> 15 * ability to fill in the voiding diaries * signed informed consent exclusion criteria: * patients using diuretics * patients with malignancies * pregnancy

Keywords: obstructive sleep apnea nocturia lower urinary tract symptoms voiding diary nocturnal polyuria
effects of pulmonary vasodilation upon va coupling in fontan patients

Conditions: Congenital Heart Disease; Fontan

Summary: the study involves documenting the effects of inhaled nitric oxide upon ventricular-arterial coupling in patients with congenital heart disease and passive pulmonary blood flow. consenting patients undergoing a clinically-indicated cardiac catheterization will be given inhaled nitric oxide for 10 minutes while intraventricular pressure-volume analysis will be make via conduction catheters.

patients with complex congenital heart disease and single ventricle physiology typically undergo a staged surgical palliation to a situation where the single ventricle is recruited as the systemic pumping chamber and some (following a glenn surgery) or all (following a fontan surgery) systemic venous return flows passively to the lungs. while this physiology eliminates ventricular volume loading and normalizes systemic arterial oxygen saturations, there remain a number of physiologic burdens that limit functional capacity and life expectancy. evidence suggests that this surgical imposition of the systemic and pulmonary vascular beds in series results in ventricular loading conditions that adversely affect ventricular function. at present, there exist limited means by which to mitigate these burdens, however, new therapies directed at reducing total pulmonary resistance may favorably affect patients with this physiology by reducing systemic venous pressures and improving both ventricular preload and afterload. one such therapy is inhaled nitric oxide (ino), which is a selective pulmonary vasodilator that has been shown to reduce total pulmonary resistance and improve systemic venous pressures in this patient population. however limited data exist regarding the affects of pulmonary vasodilators like ino on ventricular loading and ventricular-arterial coupling. this study proposes to assess the effects of pulmonary vasodilator therapy upon ventricular loading and ventricular-arterial coupling in single ventricle patients with passive pulmonary blood flow presenting for elective cardiac catheterization. the study components include obtaining routine (they would be obtained as a part of the clinically-indicated catheterization) hemodynamic measurements with hi-fidelity catheters rather than standard fluid-filled catheters, as well as simultaneous additional measurements with the same catheters at rest and during administration of ino.

Eligibility criteria:
inclusion criteria: * all consecutive patients with single ventricle hearts having passive pulmonary blood flow presenting to the cardiac catheterization laboratory for clinically indicated cardiac catheterization. exclusion criteria: * patients with coarctation of the aorta or known bilateral femoral arterial obstruction * patients with known severe systemic venous/fontan obstruction * patients already receiving sildenafil or other vasodilator therapy

Keywords: nitric oxide ventricular-arterial coupling congenital heart disease
a study of the effect of ezetimibe on glucose metabolism in type 2 diabetics with hypercholesterolemia (p06541)

Conditions: Hypercholesterolemia

Summary: this study will examine the effect of ezetimibe on glucose metabolism in participants with type 2 diabetes and hypercholesterolemia.the primary hypothesis is that change in glycated hemoglobin (hba1c) from baseline in the ezetimibe treatment group will be non-inferior to the placebo control group.


Eligibility criteria:
inclusion criteria: * have hypercholesterolemia (high cholesterol) and have been diagnosed with type 2 diabetes that is being treated with oral anti-diabetic drugs or insulin or both. * no change in the medication (drugs, dose and administration) for the treatment of diabetes within previous 12 weeks with exception of small changes in insulin dosing * no change in diet and exercise therapy within previous 4 weeks exclusion criteria: * coexisting disease (hemoglobinopathy, hemolytic anemia, etc.) that may affect hba1c measurement * homozygous or heterozygous familial hypercholesterolemia * previously received ezetimibe * hypercholesterolemia associated with: hypothyroidism, obstructive gall bladder or biliary disease, chronic renal failure or pancreatitis * hyperlipidemia caused by medication
molecular study and precision medicine for colorectal cancer

Conditions: Advanced Colorectal Carcinoma; Recurrent Colorectal Carcinoma

Summary: researchers collect specimens from advanced or recurrent colorectal cancer (crc) patients to conduct molecular profiling and establish tumor organoids (pdos)/ patient-derived xenografts (pdxs). the aim of this study is to identify clinical actionable targets and predict in vivo response of the tumor to targeted drugs by using pdos/ pdxs. and the above-mentioned studies will provide the patients with potential personalized cancer treatment options.

patient-derived organoid is a model that can recapitulate the histology and behavior of the cancer from which it is derived, and is increasingly used as a tool for drug development in pre-clinical settings. clinical treatment option of colorectal cancer now is quite limited. by molecular profiling, clinical actionable alterations may be identified. and according to the genomic investigation results, we can find the matched targeted drugs, following further testing in the organoids and pdxs. this will provide an opportunity to guide the precision medicine.

Eligibility criteria:
inclusion criteria: * male or female patients, age 18 to 75 years old * patients with a documented (histologically- or cytologically-proven) advanced or recurrent colorectal cancer * patients must have eastern cooperative oncology group (ecog) performance status =\< 1 and a life expectancy of at least 3 months * patients, both male and female, who are either not of childbearing potential or who agree to use a medically effective method of contraception during the study and for 3 months after the last dose of study drug. * patients with the ability to understand and give written informed consent for participation in this trial, including all evaluations and procedures as specified by this protocol. exclusion criteria: * patients with any other life-threatening illness, significant organ system dysfunction, or clinically significant laboratory abnormality, which, in the opinion of the investigator, would either compromise the patient's safety or interfere with evaluation of the safety of the study drug * patients with abnormal coagulation function, bleeding tendency, or receiving thrombolytic or anticoagulant therapy * patients with any other serious/active/uncontrolled infection, any infection requiring parenteral antibiotics, or unexplained fever \> 38ºc within 2 weeks prior to first study drug administration. * patients with a history of human immunodeficiency virus (hiv) or any other immunodeficiency disease. * patients who are currently using certain drugs that are not permitted * patients with a psychiatric disorder or altered mental status that would preclude understanding of the informed consent process and/or completion of the necessary studies * patients with the inability, in the opinion of the investigator, to comply with the protocol requirements
a phase 1/2, study evaluating the safety, tolerability, pk, and efficacy of sotorasib (amg 510) in subjects with solid tumors with a specific kras mutation (codebreak 100)

Conditions: KRAS p.G12C Mutant Advanced Solid Tumors

Summary: evaluate the safety and tolerability of sotorasib in adult subjects with kras p.g12c mutant advanced solid tumors. estimate the maximum tolerated dose (mtd) and/or a recommended phase 2 dose (rp2d) in adult subjects with kras p.g12c mutant advanced solid tumors.


Eligibility criteria:
inclusion criteria: * men or women greater than or equal to 18 years old. * pathologically documented, locally-advanced or metastatic malignancy with, kras p.g12c mutation identified through molecular testing. exclusion criteria * active brain metastases from non-brain tumors. * myocardial infarction within 6 months of study day 1. * gastrointestinal (gi) tract disease causing the inability to take oral medication.
tonsillectomy vs. tonsillotomy in adults with obstructive sleep apnea

Conditions: Obstructive Sleep Apnea; Tonsillar Hypertrophy

Summary: the primary purpose of this randomized controlled trial s to investigate whether surgical reduction of palatine tonsils (tonsillotomy) is a superior treatment compared to complete surgical removal of palatine tonsils (tonsillectomy) in adults patients with obstructive sleep apnea and concomitant enlarged tonsils in regards of perioperative and postoperative morbidity.


Eligibility criteria:
inclusion criteria: * age \> 18 years * tonsil size 2, 3, or 4 (friedman tonsil scale) * confirmed osa with sleep analysis not older than a year either crm or psg * asa 1 or 2 * bmi \< 35 kg/m2 exclusion criteria: children age \< 18 years * previous pharyngeal surgery such as previous tonsillotomy, tonsillectomy or palatal surgery * epileptic disease or severe neurological comorbidity. * asa 3, or 4. * central sleep apnea * previous thrombotic disease. * currently treated with sleep medications * no collapse of oropharyngeal lateral wall during dise * dropout of study, lack of sleep analysis or lack of postoperative dise.

Keywords: tonsillectomy obstructive sleep apnea (osa) tonsillotomy intracapsular reduction of tonsils drug induced sedation endoscopy
interprofessional mindfulness practices advancing cancer teamwork

Conditions: Burn Out

Summary: the purpose of the research is to understand if mindfulness team training can improve the well-being and teamwork in caring for oncology patients. this study will enroll healthcare professionals in oncology teams, including clinic nurses, nurse managers, medical assistants, social workers, technicians, patient navigators, advanced practice providers, and physicians at uw madison. participants will be on study for up to approximately 6 months.

aim 1: determine the effect of resilience training on team resilience and well-being. the investigators test the hypothesis that resilience training provided to interprofessional oncology care teams will improve team resilience and individual well-being. aim 2: determine the feasibility and acceptability of a resilience training on team resilience. the investigators test the hypothesis that resilience training is feasible and acceptable in interprofessional oncology care teams.

Eligibility criteria:
inclusion criteria: * a care provider in an oncology clinic team (clinic nurse, nurse manager, medical assistant, technician, social worker, patient navigator, advanced practice provider, physician) exclusion criteria: * does not participate in patient care or support services

Keywords: oncology health care clinicians mindfulness well-being
does indoxyl sulfate have a role in uremic pruritus?

Conditions: Pruritus

Summary: itching is a widespread and disturbing complain from patients with chronic kidney disease (ckd); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe itching. the pathogenesis of renal pruritus is multifactorial. triggering factors may include uremia-related abnormalities, accumulation of uremic toxins, systemic inflammation and cutaneous xerosis. indoxyl sulfate (is) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan accumulating in patients with end-stage renal disease.

patients with end-stage renal disease undergoing hemodialysis complaining of itching not related to other cause than renal failure will take activated charcoal with foods and serum level of indoxyl sulphate will be studied

Eligibility criteria:
inclusion criteria: patients with end-stage renal failure with itching undergoing regular hemodialysis exclusion criteria: patients with other causes of itching as psoriasis, atopic dermatitis, scabies, and lichen planus
gip and glp-1 in type 1 diabetes

Conditions: Hypoglycemia

Summary: investigation of glucose-dependent insulinotropic polypeptide (gip) effects at hyper and hypoglycemia in type 1 diabetes.


Eligibility criteria:
inclusion criteria: • diagnosed with type 1 diabetes (who criteria) exclusion criteria: * hba1c \> 9 % * liver disease (alat/asat \> 2 x upper normal limit) * diabetic nephropathy (s-creatinine \> 130 µm or albuminuria) * proliferative diabetic retinopathy (anamnestic) * severe arteriosclerosis or heart failure (nyha group iii or iv) * anemia * treatment with medication not applicable to pause for 12 hours * c-peptide increase after 50 g iv arginine