Kornimate/medical-research-clean huggingface dataset:
postpartum urinary retention with essential oils (pure)

Conditions: Urinary Retention

Summary: the purpose of this study is to examine the effectiveness of peppermint oil to promote voiding and reduce urinary catheterization among postpartum women.


Eligibility criteria:
inclusion criteria: * postpartum patients at mount carmel east, mount carmel west, and mount carmel st. ann's hospital * 18 years or older * able to read and understand english * unable to spontaneously void within 6 hours after vaginal delivery or within 6 hours after straight catheter or within 6 hours after catheter removal for cesarean delivery. exclusion criteria: * patients who have an allergy to peppermint oil * patients who have asthma * patients who report sensitivity to smells * patients who have a clinical condition which precludes walking/use of standard toilet
cadonilimab in combination with anlotinib in the treatment of locally progressive or metastatic melanoma with first-line therapy failure

Conditions: Melanoma

Summary: this study is an open-label, multicenter, single-arm phase ii clinical study to evaluate the effectiveness of cadonilimab (ak104) in combination with anlotinib in the treatment of locally advanced or metastatic melanoma.


Eligibility criteria:
inclusion criteria: 1. age \>18 years and ≤ 75 years 2. has a histologically confrmed diagnosis of malignant melanoma 3. previously received failed first-line treatment for melanoma 4. patients may have a history of liver metastases, but the metastases should be less than 3 5. patients with treatment-asymptomatic brain metastases may be included, must be free of disease progression on computed tomography (ct) or magnetic resonance imaging (mri), stable for at least 3 months, and free of steroid medication for at least 4 weeks 6. those with at least 1 measurable lesion (recist version 1.1) 7. ecog 0-1 8. non-lactating patients 9. good organ function exclusion criteria: 1. previous (within 5 years) or concurrent other malignant tumors, except for cured local tumors (such as basal cell skin cancer, squamous cell skin cancer, superficial bladder cancer, cervical carcinoma in situ, breast carcinoma in situ, etc.) and breast cancer without recurrence \> 3 years after radical resection 2. has an active or potentially recurrent autoimmune disease 3. history of severe allergic reaction to any monoclonal antibody and/or component of the study drug 4. known presence of active tuberculosis tb 5. currently receiving cancer treatment (chemotherapy, radiotherapy, immunotherapy, or biologic therapy) 6. received a live vaccine within 30 days prior to the first dose, or plans to receive a live vaccine during the study 7. known history of psychiatric illness, substance abuse, alcoholism, or drug abuse

Keywords: locally advanced or metastatic melanoma cadonilimab anlotinib first-line therapy failure
role of nadph oxidase in microvascular dysfunction following gdm

Conditions: Gestational Diabetes; Oxidative Stress; Vascular Endothelial Function

Summary: the purpose of this investigation is to examine nadph oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of gdm.

women with a history of gestational diabetes mellitus (gdm) are at a 2-fold greater risk for the development of overt cardiovascular disease (cvd) following the effected pregnancy. while subsequent development of type ii diabetes elevates this risk, prior gdm is an independent risk factor for cvd morbidity, particularly within the first decade postpartum. gdm is associated with impaired endothelial function during pregnancy and decrements in macro- and microvascular function persist postpartum, despite the remission of insulin resistance following delivery. collectively, while the association between gdm and elevated lifetime cvd risk is clear, and available evidence demonstrates a link between gdm and vascular dysfunction in the decade following pregnancy, the mechanisms mediating this persistent dysfunction remain unexamined. the purpose of this investigation is to examine nadph oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of gdm. in this study, the investigators use the blood vessels in the skin as a representative vascular bed for examining mechanisms of microvascular dysfunction in humans. using a minimally invasive technique (intradermal microdialysis for the local delivery of pharmaceutical agents) they examine the blood vessels in a dime-sized area of the skin in women who have had gdm. as a compliment to these measures, the investigators also collect endothelial cells from an antecubital vein and measure nadph oxidase expression and markers of oxidative stress in these cells.

Eligibility criteria:
inclusion criteria: * 18 years or older * pregnant within 5 years of the study visit * had gestational diabetes diagnosed by their obstetrician and confirmed according to the american college of obstetricians and gynecologists criteria for gestational diabetes. * or without a history of gestational diabetes exclusion criteria: * skin diseases * current tobacco or electronic cigarette/vape pen use, * diagnosed or suspected hepatic or metabolic disease including diabetes, * statin or other cholesterol-lowering medication, * current antihypertensive medication, * history of preeclampsia or gestational hypertension, * current pregnancy, * body mass index \<18.5 kg/m2, * allergy to materials used during the experiment.(e.g. latex), * known allergies to study drugs

Keywords: gestational diabetes postpartum vascular
safety and effectiveness of autologous adipose tissue derived mesenchymal stem cell implantation in patients with cp

Conditions: Cerebral Palsy

Summary: safety and effectiveness of autologous adipose tissue derived mesenchymal stem cell implantation in patients with cp

the purpose of this study is to investigate the efficacy and safety of autologous transplantation of adipose tissue derived mesenchymal stem cells (mscs) in patient with cerebral palsy(cp)

Eligibility criteria:
inclusion criteria: * children with spastic cerebral palsy of spastic paraplegia or quadriplegia involving the two side occurred at birth or before birth * age : 36 months - 12 year, males and females * subjects who understand and sign the consent form for this study * kaufman assessment battery for children 50\<k-abc\<100 exclusion criteria: * the last three months had seizures or epilepsy patients taking the durg * genetic diseases * recent cancer patients within 1 year * patients witn a psychiatric disorder that may interfere in the clinical trial * participating another clinical trials within 3 months * recently there is a change of the abrupt symptoms within three months of the patient * subjects with a infectious disease include hiv and vdrl * patients who penicillin hypersensitivity reactions * other pathologic conditions or circumstances that difficult participation in the study according to medical criteria
the research on 89zr-abt806 pet imaging in high grade glioma

Conditions: Glioma

Summary: the epidermal growth factor receptor variant ⅲ(egfr vⅲ) is commonly detected in high-grade gliomas, which is also an important epitope in egfr-targeted therapies and correlated to poor prognosis. however, detection of this mutant usually needs resected tumor samples. for biopsy samples, test results may not represent the egfr vⅲ status of the whole tumor tissues because of the heterogeneity of tumor. it is also not applicable for patients who are not suitable for surgical procedure due to the tumor location or patients' general conditions. because of the importance of the epidermal growth factor receptor (egfr) signal pathway in oncogenesis, maintenance, and progression of high grade glioma, there has been an intense effort to develop noninvasive molecular imaging approach for the selection and monitoring of egfr-targeted therapies. based on investigators' previous study, investigators plan to perform pet scanning on the participants with high grade gliomas after the injection of the second generation of egfr tracer ,89zr-abt806, which can be specifically binded to egfr vⅲ . after fusing the pet and mri images, investigators precisely obtain the tissue from the"hot-spot" on the pet image through multimodal-neuronavigation-guided tumor biopsy. egfrvⅲ status will be detected by molecular methods to analyze the correlation with the 89zr-abt806 pet image qualitatively and quantitatively. investigators' final goal is to detect egfr vⅲ by noninvasive molecular imaging procedure for the clinical outcome prediction and the selection of egfr-targeted therapies.


Eligibility criteria:
inclusion criteria: 1. clinical manifestations and imaging examination (ct, mri, et al) are in accordance with high grade glioma 2. no pet/ct scanning contraindications 3. no mri scanning contraindications 4. patients older than 18 years old 5. ecog score between 0 to 2 6. patients with sufficient bone marrow, kidney and liver function reserve. 7. all patients gave written informed consent. exclusion criteria: 1. patient who has received immune therapy, radiation therapy, chemotherapy, hormone drugs, biological products or other clinical trials within 14 days. 2. patient who has received egfr monoclonal antibody therapy within 4 weeks. 3. patients who has not fully recovered form the past drug toxicity reaction (ctcae in grade 2 or above). 4. patient who has received major surgery within 7 days. 5. patients with allergies to immunoglobulin. 6. breastfeeding women. 7. pregnant women 8. patients with severe clinical condition. 9. inability to give informed consent

Keywords: glioma pet egfr viii multimodal neuronavigation molecular pathology pet-ct neuronavigation
new markers for treatment response to radiotherapy in prostate cancer

Conditions: Prostate Cancer

Summary: the actual follow-up of patients undergoing definite radiotherapy for prostate cancer includes regular measurements of prostate specific antigen (psa). successful radiotherapy is critically dependent on local control of cancer; however, psa takes 2-3 years to reach a nadir after therapy. we aim at collecting blood/urine after prostate massage before, and after radiotherapy in order to define new markers predicting local control earlier and more precisely than psa.

patients will be closely followed for 5 years (weeks 0, 2, 4, 6, and months 2, 3, 6, 9, 12, 18, 24, and then yearly). each assessment includes psa measurement, urine collection after prostatic massage, and blood collection.

Eligibility criteria:
inclusion criteria: * all patients undergoing radiotherapy of biopsy confirmed clinically localised adenocarcinoma of the prostate exclusion criteria: * patients with inflammatory processes of the rectum * patients with no rectum due to previous surgery

Keywords: radiotherapy markers
3 ultrasound guided plane blocks for perioperative analgesia in patients undergoing radical cystectomy

Conditions: Cancer, Bladder; Surgery; Anesthesia; Analgesia; Block

Summary: radical cystectomy is the gold standard treatment for muscle invasive bladder cancer as well as some t1 and non-invasive disease. it is a major operation with significant perioperative morbidity and complications. pain is one of the most important complications to be managed. regional blocks as a part of multi-modal analgesia are considered main strategies of enhanced recovery after surgery (eras) decreasing post-operative complications including post-operative pain and post-operative hospital stay. they also have an upper hand over systemic intravenous opioids decreasing the risk for post-operative delirium specially in old age patients. thoracic paravertebral plane block (tpvpb), intra muscular quadratus lumborum plane block (qlpb) and erector spinae plane block (espb) are among these regional anesthesia techniques for pain management. erector spinae plane block is an emerging block, with low risk and more feasibility, but efficacy hasn't been compared to quadratus lumborum and paravertebral plane blocks altogether in radical cystectomy surgeries. all these blocks are effective in reducing postoperative pain and the need of analgesia in radical cystectomy surgery; this is a comparative study between the three blocks in this population.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) class ii - iii. * adult patients scheduled for radical cystectomy. exclusion criteria: * patient refusal. * uncooperative patients. * patients with known allergies to local anesthetics. * bleeding disorders or coagulopathy. * anatomical abnormality or infection at injection site. * patients receiving opioids for chronic analgesic therapy. * spinal anesthesia or any other regional anesthesia.

Keywords: erector spinae plane block quadratus lumborum plane block paravertebral block ultrasound-guided radical cystectomy analgesia anesthesia
endotracheal intubation using macintosh laryngoscope, glidescope, airwayscope during chest compression with adjustment height of a bed

Conditions: Tracheal Intubation; Cardiac Arrest

Summary: the purpose of this study is to determine whether a bed height make an effect to endotracheal intubation with macintosh laryngoscope, glidescope and airwayscope during chest compressions in- hospital simulation cardiac arrest.


Eligibility criteria:
inclusion criteria: * experience of intubation \> 50 times * postgraduates year 1,2,3,4 and emergency physicians in emergency department exclusion criteria: * wrist or low back disease

Keywords: intubation cardiopulmonary resuscitation manikin study
incisional negative pressure wound therapy for preoperatively irradiated lower extremity soft tissue sarcoma wounds

Conditions: Sarcoma; Cancer; Infectious Disease

Summary: this is a study comparing two methods of dressing a post operative wound that are currently in practice. one method is a traditional dry gauze dressing. the other method is using a negative pressure dressing that provides gentle suction on the wound. the investigators will attempt to determine how well the use of post-operative negative pressure dressing reduces wound healing problems in patients who have surgery after radiation for a sarcoma in the thigh or leg.

postoperative surgical site infections pose a significant challenge to the orthopaedic oncologist, especially in wounds that have been previously irradiated with neo adjuvant external beam radiation therapy (ebrt). there are many studies demonstrating the relatively high risk of wound complications after lower extremity sarcoma resection. published data suggest that these preoperatively radiated wounds have a postoperative infection rate of 17%-44% with "traditional" dressings (e.g. dry gauze surgical dressings). a prospective series of 190 patients and showed a wound complication risk of 35% in preoperative irradiated wounds. the morbidity associated with wound complications can range from moderate (prolonged dressing changes) to severe (life or limb threatening infection). patients who develop wound complications have been shown to longer hospitalizations and higher costs \[ref\]. anatomic location of the tumor has been shown to be a risk factor for the development of wound complications with lower extremities being higher risk than upper extremities. there are several published studies examining the effect of negative pressure wound therapy (npwt) on high risk surgical wounds. abdominal wound complications can be reduced with the use of incisional npwt. in the orthopaedic literature the use of negative pressure incisional dressings have been shown to lower the risk of wound complications in total hip arthroplasty, acetabular fractures, and extremity fractures. to our knowledge, there have not been any published studies on the utility of negative pressure wound therapy in previously irradiated soft tissue sarcoma wounds. the investigators feel that this high risk patient cohort could potentially benefit from reducing wound complications through npwt and is an ideal population to study its effect.

Eligibility criteria:
inclusion criteria: * age\>18 * willing to consent to randomization and able to participate in the study * lower extremity soft tissue sarcoma necessitating radiation prior to surgical resection * primary closure of wound * patients scheduled for surgical resection exclusion criteria: * flap coverage or skin graft * patients scheduled for amputations as local control of their tumor * sarcomas where radiation is not planned preoperatively * repeat surgeries for oncologic reasons (positive margins) * known allergy to adhesive tape
the fourth left atrial appendage occlusion study

Conditions: Atrial Fibrillation; Stroke, Ischemic; Systemic Embolism

Summary: laaos-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.

laaos-4 is a multicentre, prospective, open-label, randomized controlled trial with blinded assessment of endpoints (probe) to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.

Eligibility criteria:
inclusion criteria: 1. (a) persistent or permanent atrial fibrillation or (b) paroxysmal atrial fibrillation in participants with a history of ischemic stroke or systemic embolism 2. increased risk of stroke, defined as a cha2ds2-vasc stroke risk score of ≥ 4. \[note: the acronym cha2ds2-vasc stands for congestive heart failure, hypertension, age ≥75 (doubled), diabetes, stroke (doubled), vascular disease, age 65 to 74 and sex category (female).\] 3. treatment with oral anticoagulants (vitamin k agonist or factor xa inhibitor) for at least 90 days prior to enrollment, and no documented plan to discontinue treatment with oral anticoagulants for the expected duration of the trial. exclusion criteria: 1. age \< 18 years 2. current left atrial appendage thrombus 3. prior left atrial appendage occlusion or removal (surgical or percutaneous) 4. prior percutaneous atrial septal defect or patent foramen ovale closure 5. prior atrial fibrillation ablation unless evidence of recurrent qualifying atrial fibrillation present at least 30 days following ablation 6. planned atrial fibrillation ablation within 90 days of enrollment 7. individuals being treated with direct thrombin inhibitors 8. women of childbearing potential unless they agree to employ effective birth control methods throughout the study 9. anticipated life-expectancy of \< 2 years 10. patient unable or willing to give informed consent

Keywords: watchman left atrial appendage (laa) laa device left atrial appendage occlusion
effects of medical treatment of icas with hemodynamic disorders based on mr-ffr

Conditions: Stroke, Ischemic; Intracranial Atherosclerosis

Summary: this multicenter prospective cohort study aims to compare the difference in the effects of medical treatment within 1 year between the two groups of icas patients divided hemodynamically by magnetic resonance fractional flow reserve. pc mra will be applied for ffr measurement. the primary outcome is the composite of ischemic stroke or death related to the qualifying artery territory for 1 year.


Eligibility criteria:
inclusion criteria: 1. patients aged from 30 to 80 with symptomatic icas lesion in anterior circulation. 2. 50% to 99% stenosis (in accordance with modified wasid method) confirmed by dsa, cta or mra. 3. mrs 0-2 points 4. informed of the study protocol and objectives. exclusion criteria: 1. previous endovascular treatment or surgery for cerebrovascular diseases 2. large cerebral infarction (more than 1/2 mca perfusion area) according to mri 3. combined with other neurological diseases, such as aneurysm, arteriovenous malformation, tumor, hydrocephalus, cerebral trauma, cerebral hemorrhage, multiple sclerosis, epilepsy and intracranial infection. 4. pregnancy or in the preparation for pregnancy 5. patients who cannot tolerate or do not allow mr screening, including metal implanting and claustrophobia 6. contraindication for antiplatelet drugs or statins 7. patients with severe dementia or mental disorders, who cannot cooperate with examination

Keywords: intracranial atherosclerotic diseases fractional flow reserve hemodynamics stroke
biological response to exercise : a metabolomic study in peripheral artery disease (bior)

Conditions: Peripheral Artery Disease

Summary: the measurement of the transcutaneous oxygen pressure during walking allows to estimate the importance of ischemia, bilaterally and segment of limb by segment of limb. the determination of the metabolic compounds concentration, with metabolomic approach, is emerging in physiology and exercise. this pilot study focuses on the feasibility of the metabolomics analysis with micro method , by capillary drawing from earlobe sampling, for patients with peripheral artery disease (pad)

ankle brachial index is measured at rest for alml subjects. blood sample (180-360 microliter) will be collected at rest transcutaneous oxygen pressure is measured at the chest, calves and buttocks and results will be expressed as the minimal value of the drop index (limb changes minus chest changes) patients walk on treadmill (2mph 10% slope) until exertional limb pain. blood sample (180 microliter) will be collected again, at minute 3 of recovery from walking correlation of each metobolite increase to the sum of drop values wil be studied.

Eligibility criteria:
inclusion criteria: * age \> 18 years old * patient able to walk on a treadmill * patient agrees to be involve in the protocol and sign the consent form exclusion criteria: * patient not covered by the french health insurance * patient has a wash-out period for another clinical trial * patient with comorbidity as bleeding disorder or with a anticoagulant therapy