Kornimate/medical-research-clean huggingface dataset:
a randomised comparison of left and right sided approaches to ablation of the atrioventricular junction

Conditions: Atrial Fibrillation

Summary: this study will compare right sided atrioventricular node ablation to left sided atrioventricular node ablation

right-sided atrioventricular node ablation has been the initial conventional approach however up to 18.5% of patients require switching to a left sided approach or have a challenging procedure. previous studies have found that left sided ablation is more efficacious than right-sided ablation requiring less than 5 applications of radiofrequency energy to induce atrioventricular block. this study will compare right sided atrioventricular node ablation to left sided atrioventricular node ablation

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * referred for atrioventricular node ablation for any such indication exclusion criteria: * stroke or transient ischaemic attack (tia) within 6 months * myocardial infarction within 6 months * medical conditions limiting expected survival to \<1 year * moderate to severe aortic stenosis * history of aortic or mitral valve replacement * pregnancy or breast feeding women

Keywords: atrial fibrillation atrioventricular node
modernizing perinatal syphilis testing

Conditions: Syphilis

Summary: treponema pallidum is a bacterium that causes the disease syphilis. the primary objective of the study is to evaluate the testing performance of two diagnostic molecular techniques \[quantitative polymerase chain reaction (qpcr) and transcription-mediated amplification (tma)\] for the detection of treponema pallidum in maternal and neonatal specimens from participants with the diagnosis of syphilis using the centers for disease control's (cdc's) sexually transmitted infections (sti) treatment guidelines for adult and congenital syphilis.


Eligibility criteria:
inclusion criteria: * maternal diagnosis of syphilis by 2021 cdc sti guidelines, irrespective of treatment status; and viable pregnancy with gestational age ≥ 12 weeks or postpartum ≤ 96 hours from delivery * neonates of pregnancies affected by syphilis ≤ 72 hours of birth exclusion criteria: * pregnant individuals and neonates who do not meet the criteria of syphilis (false positive) * planning to move outside of study prior to nd testing
impact of a snoezelen element on anxiety in patients during oral care: a real-life study at nantes university hospital

Conditions: Odontologic Disorders

Summary: research on dental phobia highlights both external causes, like traumatic experiences or media influence, and internal factors, such as genetics and personality traits. while many studies focus on technical aspects of dental care, few explore how the care environment affects patient anxiety. the snoezelen concept, developed in the 1970s, uses sensory stimulation (sight, sound, smell, and touch) to reduce anxiety. initially designed for individuals with neurocognitive disorders, it creates a calming environment and has since been adopted in various healthcare settings. at nantes university hospital, the dental department will test the tovertafel pixie®, a sensory projector designed to distract patients and reduce anxiety. its mobility allows it to be used in waiting rooms and treatment areas, projecting onto ceilings, walls, or tables. this real-life study will assess whether patients exposed to the projector experience less anxiety compared to those who are not, with the goal of improving patient care and dental treatment experiences.

the study involves a questionnaire that the dental department usually provide to our patients, which is partially completed by the patient and partially by the practitioner at the end of the treatment session. no follow-up visit is required.

Eligibility criteria:
inclusion criteria: * adult patient, over 18 years old; * consulting in the specialized care unit; * who understands french; * receiving care in the specialized dentistry unit and capable of expressing themselves independently regarding the various items in the questionnaire, whether orally, in writing, through a speech synthesis system, or using pictograms; * able to provide consent to participate. exclusion criteria: * receiving care in the specialized care unit who are unable to express themselves independently regarding the various items in the questionnaire, whether orally, in writing, through a speech synthesis system, or using pictograms; * refuse to participate in the study; * under guardianship, curatorship, or legal protection.
escape : evaluation of spinal conservation by endoscopic procedures to avoid fusion

Conditions: Spinal Stenosis; Spondylolisthesis

Summary: the recent development and expansion of endoscopic surgery has made it possible to offer an alternative to this therapeutic escalation. this method allows decompression procedures to be performed using optimized and minimally destructive surgical approaches, which contributes to preserving the physiological function of the lumbar spine and in particular its stability. the main hypothesis of the research is that the use of endoscopic techniques for decompression of the lumbar spine allows a reduction in the indication for lumbar arthrodesis.


Eligibility criteria:
inclusion criteria: * patient ≥ 18 years old * patient consulting for a medical reason involving a spinal pathology in the investigating center : syndrome adjacent to an old lumbar arthrodesis defined on preoperative radiographs by an antero-posterior translation \> 3 mm, segmental kyphosis \> 10° or a disc height reduced by more than 50%, or on preoperative mri by central stenosis of grade c or d of the schizas classification or a herniated disc grade 1 or 2 degenerative spondylolisthesis, i.e. with slippage less than 50% of the depth of the underlying vertebral body. lumbar stenosis complicating lumbar scoliosis defined by a deformation with rotation of the vertebral bodies on a frontal radiograph (absence of centering of the spinous process between the two pedicles of the vertebra concerned) and a cobb angle greater than 20° or a rotational dislocation . - indication for spinal surgery by endoscopy exclusion criteria: * patient under guardianship or curatorship, * persons deprived of liberty by judicial or administrative decision, * persons undergoing psychiatric treatment under duress requiring the consent of the legal representative * persons unable to express their consent, * persons under legal protection, * patient not affiliated to a social protection scheme.

Keywords: spine care surgery
cognitive behavioral therapy for pathological gambling

Conditions: Pathological Gambling

Summary: the purpose of the study is to evaluate a new form of counseling for pathological gambling and to see if the counseling is more effective than attending gamblers anonymous.

subjects will be assigned to counseling or be given a referral list of available gamblers anonymous meetings at the first visit based on answers to questions. assignment to counseling or gamblers anonymous will be randomly selected (i.e. chance) with an equal chance of receiving either one. for those assigned to counseling, you will meet with the therapist for 60 minutes weekly. you will receive 5 sessions of counseling. all subjects will be assessed with gambling questionnaires twice during the 5-week period and again at 3 and 6 months following the 5-week period. for those assigned to gamblers anonymous, they will be offered 5 weeks of counseling at the end of the 6-month follow-up.

Eligibility criteria:
inclusion criteria: 1. outpatient men and women age 18 to 75 2. presence of current dsm-iv pathological gambling for at least 6 months duration 3. pg is the most problematic psychiatric disorder (in the patient's and clinician's opinion) and the primary reason for seeking treatment 4. minimum score of \>5 on the south oaks gambling screen which reflects gambling severity consistent with pathological gambling exclusion criteria: 1. current clinically significant suicidality, severe depression (a score of ≥ 19 on the hamilton rating scale for depression, 17-item version)(30) or any other disorder requiring immediate intervention 2. presence of any clinical features requiring a higher level of care than outpatient treatment 3. cognitive impairment that interferes with the capacity to engage in cbt or to provide informed consent 4. dsm-iv substance abuse or dependence within the past 3 months (see screening visit) 5. current axis i diagnosis of bipolar disorder or psychotic disorder 6. previous treatment of cbt for pg (duration of at least 6 sessions); because cbt is not widely used for pg, a minimum of 6 treatments will be rare. 7. current use of psychotropic medications or within 2 months prior to study entry. 8. current participation in gambler's anonymous (ga).

Keywords: gambling
the effect of home-based walking program on peripheral neuropathy, fatigue and quality of life

Conditions: Chemotherapeutic Toxicity

Summary: the study aims to evaluate the effect of home-based walking program on peripheral neuropathy, fatigue and quality of life in patients receiving taxane and platinum-based chemotherapy.

the study was designed as a randomized controlled trial. this study will be carried out with a total of 88 cancer patients receiving taxane and platinum-based chemotherapy, 44 of whom were in the intervention group and 44 in the control group, whose treatment was started in akdeniz university hospital."home based walking program" will be applied to the patients in the intervention group for 8 weeks.within the scope of the home-based walking program, face-to-face patient education, patient education booklet, sending text messages, face-to-face and telephone counseling were planned. patient identification form, international physical activity questionnaire (ipaq- short form), national cancer institute (nci) -ctcae v5.0 toxicity criteria, cancer fatigue scale, eortc qlq-cipn20 (quality of life chemotherapy-induced peripheral neuropathy) and eortc qlq-c30 (quality of life scale), interview form will be used to collect data.

Eligibility criteria:
i̇nclusion criteria * 18 years and older (adult, older adult ) * turkish speaking-understanding ability and literate. * orientation (person, place, time) * receiving taxane and platinum-based chemotherapy treatment (monotherapy or combined). * receiving chemotherapy treatment for the first time. * the primary medical diagnosis is cancer (breast cancer, colorectal cancers and other cancers). * not having health problems that prevent walking. * agreeing to participate in the research. exclusion criteria * being bone and brain metastases * being peripheral neuropathy due to reasons other than chemotherapy (such as chronic disease, diabetes mellitus, nutritional disorders) * skin sensitivity on the hands and feet * having cardiovascular, pulmonary, musculoskeletal, or psychological disorders that limit exercise or mobility * being in another supportive program * being in the very active category according to the "international physical activity scale (ipaq- short form)" * being a severity of more than 4 points according to the "modified borg scale (mbs)" * being a score of 2 and above according to the "ecog performance scale"

Keywords: home-based walking program chemotherapy cancer peripheral neuropathy fatigue quality of life nurse
effect of bilateral erector spinae plan block in colorectal surgery

Conditions: Pain, Postoperative

Summary: in this study, it was aimed to evaluate the effects erector spina plane block (espb) on postoperative opioid consumption in the first 24 hours and pain scores after colorectal surgery.

colorectal surgery can be applied for many reasons, among these reasons, colorectal cancer (crc) takes the first place. with the understanding of the pathophysiological effects of analgesics better, the use of regional techniques in providing analgesia for patients undergoing colorectal cancer surgery has come to the fore. depending on the surgical procedure, pain faced by patients is an important problem that must be deal with in the postoperative period. in this study, the hypothesis was determined as "pre-operatively, erector spina plane block (espb) performed as part of multimodal analgesia reduces postoperative morphine consumption and pain scores." the patients were divided into two groups : group esp (erector spinae plan): in this group, patients will be administered bilateral espb (total of 40 ml, %0.25 bupivacaine) in addition to iv morphine patient-controlled analgesia (pca) for the first 24 postoperative hours. group ga (general anesthesia): in this group, patients will be administered only iv morphine patient-controlled analgesia (pca) for the first 24 postoperative hours.

Eligibility criteria:
inclusion criteria: * patients aged between 18 and 65 years * asa i , ii patients * bmi\ 45 kg) * patients who underwent colorectal surgery exclusion criteria: * patients who underwent abdominoperineal resection * patients who were evaluated as unsuccessful block in the dermatomal examination performed after the block was applied. * patients diagnosed with osas * pregnancy and breastfeeding * contraindication of regional anesthesia (coagulopathy, abnormal inr, thrombocytopenia, infection at the injection site) * hypersensitivity to local anesthetics or a history of allergy * patients with a history of opioid use longer than four weeks * patients with severe psychiatric diseases such as psychosis or dementia that limit cooperation with the patient. * patients with anatomic deformity ( advanced scoliosis and kyphotic patients. patients with pectus carinatum and pectus excavatum-like chest deformity ) * patients who do not want to participate * patients who have had previous colorectal surgery, excluding diagnostic biopsies * patients who could not be reached by phone to inquire about their pain score at 3rd month.

Keywords: regional anesthesia erector spinae plane block post-operative analgesia laparoscopy open surgery colorectal surgery
relationship between vitamins and radiologic stage in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the aim of this study is to investigate the relationship between folic acid, vitamin b12 and 25-oh vitamin d levels and radiographic staging in patients diagnosed with primary gonarthrosis.

while in the past osteoarthritis (oa) was believed to be a degenerative disease of cartilage alone, recently, many factors such as trauma, mechanical strain, inflammation, biochemical reactions, and metabolic irregularities have been shown to be involved in its etiology. until now there have been many studies done to investigate the relationship between serum 25-oh vitamin d (25(oh)d) levels and knee oa however the relationship between folic acid, vitamin b12 and knee oa has been rarely studied. therefore, the aim of this study is to investigate the relationship between folic acid, vitamin b12 and 25(oh)d levels and radiographic staging in patients diagnosed with primary gonarthrosis. the files of patients who presented to sadi konuk training and research hospital's outpatient clinic of physical medicine and rehabilitation with knee pain between june and december 2023 and were diagnosed with gonarthrosis according to the american college of rheumatology (acr) classification criteria were retrospectively reviewed. either one way anova or kruskal wallis h test was used to compare means determined based on the result of the shapiro wilk test. bonferroni posthoc was used to compare between groups. the statistical analysis was performed with statistical package for the social sciences (spss) version 21 (new york, usa) with significance set at p \< 0.05.

Eligibility criteria:
inclusion criteria: * adults (age: 50-80) with primary gonarthrosis * anterior-posterior and lateral knee direct digital radiography within 3 months of diagnosis * vitamin b12, folic acid and 25-oh vitamin d within 1 months of diagnosis exclusion criteria: * history of inflammatory or rheumatologic disease * history of lower extremity surgery * pregnancy * active malignancy * severe mental disability

Keywords: vitamin b12 folate vitamin d gonarthrosis
stapling versus 8plate for correction of genu valgus

Conditions: Deformity; Genu Valgus

Summary: in children with excessive knock knees it may be necessary to use guided growth (small surgical procedure) so the child outgrows the condition before maturity. a new implant is on the market and the investigators compare this implant (8plate) with the old technique (staples) in a randomised setup. the hypothesis is that the 8plate provides a faster correction rate and that this treatment is superior to stapling.

correcting angulating deformities of the lower limb is a subject of major interest in paediatric orthopaedics. epiphysiodesis is the technique by which unilateral bone growth is stopped. traditionally this has been performed with staple technique. the 8-plate technique is new and advocated because it is believed to reduce the risk of premature closure of the growth plate compared to stapling. the benefit of the 8-plate technique has not yet been proven in experimental or randomised clinical studies.

Eligibility criteria:
inclusion criteria: * idiopathic genu valgus * at least one year of remaining growth exclusion criteria: * unilateral conditions

Keywords: genu valgus lower limb paediatric epiphysiodesis
analysis of the dentoskeletal effects of the expander with differential opening

Conditions: Maxillary Constriction; Unilateral Posterior Crossbite; Bilateral Posterior Crossbite; Mandibular Dental Arch Constriction

Summary: this study evaluates the dentoskeletal effects of the expander with differential opening in orthodontic patients in the mixed dentition. half of participants will undergo rapid maxillary expansion (rme) using the expander with differential opening, while the other half will undergo rme using the conventional hyrax expander.

recently, a rapid maxillary expander with differential opening was developed aiming to treat maxillary constrictions greater in the anterior region compared to the posterior region of the maxillary dental arch. the aim of this study is to evaluate the dentoskeletal effects of the expander with differential opening in orthodontic patients in the mixed dentition. material and methods: fifty patients with maxillary constriction in the mixed dentition will be prospectively and randomly allocated in one of two study groups. the experimental group will comprise 25 patients who will be submitted to rapid maxillary expansion with the expander with differential opening. the control group will be comprised by 25 individuals who will undergo rapid maxillary expander with the hyrax expander. digital dental models will be acquired immediately pre-expansion (t1) and six months post-expansion (t2). the orthoanalyzer™ software will be used to measure maxillary and mandibular widths, arches perimeter, arches lengths, palatal depth, and inclinations of maxillary and mandibular canines and permanent first molars. the intergroup and interphase comparisons will be analyzed using t tests and paired t tests, respectively (p\<0.05).

Eligibility criteria:
inclusion criteria: * both sexes; * ages ranging from 7 to 11 years old; * mixed dentition; * maxillary constriction; * no previous orthodontic treatment. exclusion criteria: * cleft lip and palate and associated syndromes; * systemic and/or neurological diseases.
a safety and efficacy study of elnd002 in patients with relapsing forms of multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to determine the safety and tolerability of elnd002 in patients with relapsing forms of secondary progressive multiple sclerosis (spms) or relapsing-remitting multiple sclerosis (rrms).


Eligibility criteria:
inclusion criteria: * has either clinically definite or laboratory-supported definite relapsing forms of ms for at least 2 years * patients with spms or rrms have documented medical history of relapse in the past year or mri-documented evidence of ms activity in the past year * has had an inadequate response or intolerability to interferon and/or glatiramer acetate * is able and willing to undergo gd administration and repeat mri testing exclusion criteria: * has primary progressive ms (ppms) * any history of treatment with recombinant humanized monoclonal antibodies * has received treatment with immunosuppressant medications or experimental agents within 3 months prior to the baseline * a history of opportunistic infection or the presence of any active infection within 3 months prior to baseline * any history of congestive heart failure or currently has a pacemaker * has a known or suspected hypersensitivity to sulfonamides or any of the components of the investigational drug * has any medical history or psychiatric condition that would impact outcome or study participation * has other clinically significant abnormality on physical, neurological, laboratory, or ecg examination as listed in the protocol during the screening phase

Keywords: ms spms rrms relapsing forms of secondary progressive multiple sclerosis (spms) or relapsing-remitting multiple sclerosis (rrms)
study to assess the efficacy, safety and tolerability of (itind)

Conditions: BPH

Summary: subjects with aur secondary to bpo that comply with inclusion/exclusion criteria. a total of 50 eligible subjects will be recruited into the study to receive treatment with itind system. study duration will be 12 months post implantation, with follow-up extension of up to 3 years. extension of follow up period will not require an additional icf.

spontaneous acute urinary retention (aur) is one of the most significant complications of long-term benign prostatic hyperplasia (bph). in the past it has represented an immediate indication for surgery. between 25% and 30% of men who underwent transurethral prostatectomy (turp) had aur as their main indication in older series and today most subjects failing to void after attempted catheter removal still undergo surgery. for this reason alone, aur is an important and feared event from the viewpoint of the subject. the subject originally has inability to urinate, with increasing pain, and eventually a visit to the emergency room, catheterization, follow-up visits to the physicians, an attempt at catheter removal, and eventual recovery or surgery, which is both painful and time consuming. after the acute period most men with aur will be offered a 'trial without catheter' (twoc) and about half will resume spontaneous voiding. most men who fail a twoc, experience a recurrent episode of aur, or have moderate or severe lower urinary tract symptoms (luts) that are refractory to medical management will be considered for surgery. in the older literature, the risk of recurrent aur was cited as 56% to 64% within 1 week of the first episode and 76% to 83% in men with diagnosed bph. (http://www.ncbi.nlm.nih.gov/pmc/articles/pmc1476058/). additional researches show that ten percent of men in their seventies and 30% in their eighties will have aur within the next five years. benign prostatic hyperplasia is the cause for the aur in at least 65% of men presenting with aur. in the below study of the natural history of bph, the risk of aur was 1.6% at five years for men aged 40-49 years and 10% at 70-79 years.

Eligibility criteria:
inclusion criteria: * male with aur secondary to bpo * age ≥40 years * acute urinary retention with at least one failed trial without catheter (twoc) while on alpha blocker * ability to sign an informed consent form * prostate volume \<80 ml * life expectancy \>1 year. exclusion criteria: * suspected malignant disease of the lower urinary tract including prostate or bladder cancer * chronic retention of urine with history of either retention volume greater than one liter or upper tract obstruction * known neurogenic bladder * immunosuppression * suspected urethral strictures, bladder neck contracture, urinary bladder stones * an obstructive or protruding median lobe of the prostate * an active symptomatic urinary tract infection * enrolled in another treatment trial for any disease * previous pelvic irradiation or radical pelvic surgery * any previous prostate surgery.