Kornimate/medical-research-clean huggingface dataset:
physical exercise for cognitive rehabilitation of patients with bipolar affective disorder

Conditions: Bipolar Disorder

Summary: the goal of this clinical trial is to evaluate the impact of physical exercise (pe), as an adjuvant treatment, on the cognition of patients diagnosed with bipolar disorder who present cognitive impairments, as well as its impact on quality of life and functionality and its association with physiological variables. our specific goals are: 1. evaluate the effect of pe on the neuropsychological functions of attention, memory, verbal fluency, executive function and processing speed in patients diagnosed with bd who present cognitive impairments in these domains. 2. to evaluate the effect of pe on the quality of life and functionality of patients diagnosed with bd, as well as possible associations with cognitive functions. 3. to evaluate possible correlations between physiological variables, such as cardiorespiratory indices, strength and body composition, and improvements in cognitive functions, quality of life and functionality.

the study aims to assess the impact of structured physical exercise on the cognitive function of bipolar disorder patients presenting deficits, while investigating its association to quality of life and functionality. the study will include 72 euthymic bd patients from the bipolar disorder research program (proman) at the institute of psychiatry of the university of são paulo medical school, randomly distributed into two groups: 1) the experimental group will be submitted to supervised training sessions, three times per week, for 12 weeks, including aerobics and strength exercises, as well as treatment as usual (tau); and 2) the control group will be submitted exclusively to tau. cognitive function, depressive and manic symptoms, quality of life and functionality will be assessed at baseline and at follow-uo (week 12), for both groups. statistical hypothesis testing, assessing the presence of statistically significant differences between groups, pre and post intervention, should be available on the third quarter of 2025.

Eligibility criteria:
inclusion criteria: * diagnosis of bipolar disorder (bd) i and ii according to dsm-5 * age: 18 - 55 years old * complete primary education * euthymic (ymrs \< 8 and madrs \< 12) * presence of cognitive impairments (cobra \> 14 and scip \< 75) * estimated iq ≥ 80 * no medication changes in the last month * having been without regular pe practice for six months * signature of the tcle exclusion criteria: * organic mental disorder * bmi \> 40 * alcohol or drug abuse in the last 6 months * use of benzodiazepines or beta-blockers in the last month

Keywords: bipolar disorder
the effect of galvanic stimulation on vhit and vemp tests

Conditions: Vestibular System Disorder

Summary: introduction: galvanic vestibular stimulation (gvs) is a well-established technique with a history spanning over a century, primarily used to manipulate the vestibular system. recent interest has surged in its potential for understanding human vestibular function and aiding in functional recovery. gvs applies electrical currents to the mastoid region, modulating vestibular afferents, and induces specific effects based on the participant's posture and current polarity. while gvs's impact on the central nervous system and its potential to aid in functional recovery have been studied, its immediate effects on vestibular reflexes remain less explored. methods: in this study, thirty healthy adult participants underwent ocular and cervical vestibular evoked myogenic potential (vemp) tests, as well as the velocity head impulse test (vhit) before and immediately after one hour of gvs application. statistical analyses were performed to assess changes in vemp and vhit results.


Eligibility criteria:
inclusion criteria: * no history of hearing loss and/or balance disorders * no physical (neck) problems * no history of psychological or neurological disorders * not using alcohol and/or vestibular suppressant drugs regularly * feeling balanced in daily life exclusion criteria: * history of hearing loss and/or balance disorders * physical (neck) problems * history of psychological or neurological disorders * using alcohol and/or vestibular suppressant drugs regularly

Keywords: galvanic vestibular stimulation vemp vhit
evaluation and characterisation of microplastics and nanoplastics in joint synovial liquid

Conditions: Osteoarthritis, Knee; Knee Arthritis; Gout Arthritis; Microcrystal Disease

Summary: the research study aims to evaluate the synovial fluid to highlight the presence of possible micropolymers (micro/nanoplastics) in order to better understand the pathophysiology of joint degenerative processes. for patients with liquid under tension at the joint level, the symptomatology often requires evacuation by puncture under ultrasound guidance. the intervention will be performed only for patients for whom this therapeutic indication exists anyway by their physician. the investigators want to use this liquid for microscopic and spectrophotometric evaluation.


Eligibility criteria:
inclusion criteria: * arthritis of the knee with liquid aspiration recommendation * age \>18 years exclusion criteria: --refusal of the patient to participate -age\<18 years
clinical assessement of glazed versus polished lithium disilicate crowns in surface roughness and enamel antagonists wear

Conditions: Tooth Decay

Summary: it is believed that final glazing yields the most acceptable ceramic surfaces in terms of smoothness. however, since reglazing must be performed in a dental laboratory with the use of a thermal furnace, it requires multiple office visits. repeated firings have a destructive effect on ceramic surfaces and can cause deformation. conversely, polishing is easy and simple and can be accomplished in a single session.


Eligibility criteria:
inclusion criteria: * patients from 18-50 years old who are able to read and sign the informed consent document. * physically and psychologically able to tolerate conventional restorative procedures. * have no active periodontal or pulpal diseases, have teeth with good restorations. * patients have no temporomandibular disorders. * each participant needed a crown on either a first or second premolar or first or second molar in any arch. * teeth selected shoud include: restorability with a crown:root ratio of at least 1:1. presence of an opposing natural tooth which was non-restored or minimally restored. the presence of two non-restored or minimally restored teeth opposing each other on the same quadrants as the crowned tooth and the opposing to serve as enamel controls. minimally restored was defined as teeth which have no restoration greater than a class ii amalgam restoration. - willing to return for follow-up examinations and evaluation. exclusion criteria * patients in the growth stage with partially erupted teeth. * patients with poor oral hygiene and motivation. * pregnant women. * psychiatric problems or unrealistic expectations. * lack of opposite occluding dentition in the area intended for restoration. * patients with temporomandibular disorders.
trial on short-chain fructooligosaccharides, microbiota, and constipation in adults

Conditions: Functional Constipation

Summary: rationale: the dietary short-chain fructooligosaccharides have been shown to increase fecal bacterial mass and fermentation metabolites which might stimulate gut motility. therefore, these dietary non-digestible carbohydrates might relieve functional constipation. objective: study the effect of short-chain fructooligosaccharides on functional constipation. study design: a 16-week, randomized, placebo-controlled, double-blind cross-over trial with intervention periods of 4 weeks with a run-in period of 4 weeks and a wash-out period of 4 weeks. study population: human subjects with functional constipation according to romeiii criteria (total n=120; male and female; 18-75 yr). intervention: placebo and one out of 3 dosages of short-chain fructo-oligosaccharides, (degree of polymerisation of 3-5; 2, 4 and 8 g/day) for 4 weeks. scfos will be given as oral chews. main study parameters: the primary parameter is the number of complete bowel movements per day in subjects with functional constipation according to rome iii criteria. secondary outcomes are stool consistency (bristol stool scale), stool frequency, severity of symptoms (constipation scoring system; css) and quality of life (patient assessment of constipation quality of life; pac-qol).


Eligibility criteria:
inclusion criteria: * age 18-75 yr * agree to study design (signed informed consent) * at least two of the following symptoms ≥25% of the time with criteria fulfilled for the last 3 months with symptom onset at least 6 months prior to inclusion (rome iii criteria for functional constipation): * straining, lumpy or hard stool * sensation of incomplete evacuation * sensation of anorectal obstruction ⁄ blockage * use of manual manoeuvres * \<3 bowel movements per week * availability of internet connection * bmi 20-30 * male or female * willingness to abstain from functional ingredients and such as probiotics, prebiotics and foods containing high amounts of fermentable fibers and laxatives starting 1 month prior to start of the study as well as during the washout period. exclusion criteria: * currently participating in another clinical trial * drug usage * excessive alcohol usage (\>4 consumptions/day or \>20 consumptions/week) * pregnancy or lactating * underlying disease of the gi-tract or previous laparotomy, except cholecystectomy and appendectomy * use of antibiotics within 1 month prior to inclusion * vegetarians * weight loss \> 5 kg within 1 month prior to inclusion

Keywords: bifidobacteria bristol stool scale constipation diet fructooligosacchardes microbiota oligofructose
small children, big emotions

Conditions: Emotional Disturbances

Summary: the study is a randomized controlled trial evaluating the clinical and cost-effectiveness of tuning in to kids (tik) compared to treatment as usual (tau). participants are recruited among referred children aged 2-5 years with difficulties with emotion regulation. the study setting is child and adolescent mental health services clinics. parents of children randomized to tik will attend 8 two-hourly group sessions. a brief version of tik will be offered to the child's daycare teacher. participants are assessed at baseline, week 12 and month 9 after inclusion. the primary clinical outcome is coping with toddlers' negative emotions scale.


Eligibility criteria:
inclusion criteria: * referred children aged 2-5 years * the child is enrolled in daycare * the child is displaying problems with emotional dysregulation exclusion criteria: * parent not sufficiently proficient in norwegian language to complete assessment * child protective services have ongoing assessment where the outcome may be that the child will be placed in care outside of the home of the biological parent(s) or other current caregiver * the child has already been diagnosed with an autism spectrum disorder
comparison of healing measures tibial fractures following standard intramedullary nailing or micromotion tibial intramedullary nailing

Conditions: Tibial Fractures

Summary: the primary purpose of this study is to perform a high-quality randomized control trial comparing intramedullary tibial nail fixation with standard design nails to a micromotion tibial nail device, to evaluate the rates of union and post-operative outcomes.


Eligibility criteria:
inclusion criteria: * age 18 - 85 years * stable tibial fracture recommended for surgical intervention exclusion criteria: * patients not meeting inclusion criteria * unstable fracture patterns e.g. those needing a secondary intervention - masquelet/cement spacer) * previously non-ambulatory patients * delayed presentation of fracture (\>4 weeks) * fractures that the treating surgeon indicates requires additional fixation strategies to achieve stability * patients with an achieve infection or wound at the surgical site * any previous ligament or fracture surgery on the index site * inflammatory rheumatic disease or other rheumatic disease- * immune compromised patients (hepatitis, hiv, etc.) * unwilling or unable to participate or follow study protocol
telephony or videophony for isolated elderly in maine-et-loire 49 during covid-19

Conditions: Coronavirus

Summary: the current health crisis at covid-19 is forcing us to profoundly rethink our social organizations, especially towards our most fragile seniors. prohibitions on visits to nursing homes and care services, although essential to control the epidemic, are also becoming a major source of social isolation and loneliness for these fragile populations. the only source of residual social ties during a period of confinement remains dematerialised communication via the various existing communication channels (in particular telephone calls or video telephony). as soon as the covid-19 crisis began and the first visiting restrictions were imposed on patients in the geriatric department of the angers univesity hospital and the retirement home / long-term care unit, acute care geriatric unit of angers offered patients and residents the opportunity to organize communication with their relatives via videophone calls. initial feedback from the field shows us that, contrary to our intuition, patients and residents are not necessarily asking for communication to the outside world and, when they are, the preferred channel is not necessarily video telephony but often a simple phone call with relatives. even though the vast majority of projects aimed at setting up communication aids for the elderly now rely on videophonic support, these initial observations in everyday care situations raise questions about the directions taken in this area. also, the investigators ask themselves the following question: in the absence of a physical meeting, what is the preferred means of communication for elderly people in isolation in hospital or in retirement home? this study will make it possible to propose the most appropriate solutions for breaking isolation for the hospitalized or institutionalized geriatric population in order to limit as much as possible the increase in social isolation imposed by restrictions on movement during epidemics.


Eligibility criteria:
inclusion criteria: * hospitalisation in the acute care geriatric unit (angers uh) or institutionalization in st nicolas during the isolation measures linked to the sars-cov-2 epidemic. exclusion criteria: * refusal to participate. * contraindication posed by the medical team to proposing dematerialized communication.
transitional ankle fracture management using a new joystick technique

Conditions: Tibial Fracture

Summary: to investigate the feasibility and short-term clinical efficacy of the arthrography-assisted joystick technique for the treatment of adolescent transitional ankle fracture.

adolescent transitional ankle fracture who were treated with the arthrography-assisted joystick technology.

Eligibility criteria:
inclusion criteria: 1. x-ray or computed tomography (ct) diagnosis of adolescent transitional ankle fracture. 2. after manual reduction, the displacement of both ends of the epiphyseal plate or articular surface fracture in any direction was still \> 2 mm; the arthrography-assisted joystick technique was used for treatment. exclusion criteria: 1. bilateral fracture. 2. in association with epiphyseal dysplasia and neuromuscular disease.

Keywords: arthrography, joystick technique, adolescent, ankle fracture
clinical study on the effect of brucea javanica oil emulsion injection on the survival of patients with advanced colorectal cancer who failed to receive multi-line treatment

Conditions: Colorectal Cancer; Chinese Herbal Medicine; Progression-free Survival; Quality of Life

Summary: the purpose of the study is to evaluate the safety and effectiveness of brucea javanica oil emulsion injection in patients with advanced colorectal cancer who failed to undergo multi-line treatment

this study included a prospective, multicenter, randomized controlled clinical trial. about 60 patients will be recruited in the randomized clinical trial. participants will be randomly divided into experimental group (n=30) and control group (n=30). the patients in the experimental group will receive brucea javanica oil emulsion injection combined with the best supportive treatment, based on the nccn best palliative treatment guidelines (2022. v1). the patients in the control group received the best supportive treatment based on the nccn's best palliative treatment guidelines (2022. v1). the primary end point was pfs (progression-free survival). the research protocol was approved by the relevant ethics committee. the research was conducted in accordance with the helsinki declaration and good clinical practice guidelines. the patient has written informed consent to participate in the trial.

Eligibility criteria:
inclusion criteria: * # colorectal cancer patients with stage iv third line or above treatment failure confirmed by pathology * male or female aged 18-75years # eastern cooperative oncology group (ecog) performance score 0-2 * life expectancy of at least 3 months # at least one radiographically measurable lesion per recist 1.1 # willing to join the clinic trail and sign informed consent,and able to comply with scheduled visits and treatments exclusion criteria: * with brain metastasis, braf-v600e mutation, her-2 overexpression, msi-h, ntrk fusion gene patients * patients with primary tumors at other sites * pregnant or breastfeeding woman * fertile patients who are unwilling or unable to take effective contraceptive measures during the research period until 6 months after the study end later * a history of mental disorders # patients with severe cardiac, cerebrovascular, liver, kidney, hematopoietic system dysfunction or primary disease without effective control # participated in other clinical trials of small molecule research drugs within 28 days prior to enrollment, or participated in other clinical trials of large molecule research drugs within 3 months before enrollment # known allergy or intolerance to study medications

Keywords: colorectal cancer javanica oil emulsion injection chinese herbal medicine
zirconia reinforced glass ionomer in mih

Conditions: Molar Incisor Hypomineralization

Summary: molar-incisor hypomineralization (mih) is a qualitative enamel defect, in which molars and incisors involved are prone to post-eruptive enamel breakdown leading to sensitivity, and caries. atraumatic/alternative restorative treatment (art) is a minimally invasive procedure. it can be very beneficial in managing mih-affected molars in communities with limited access to dental care. zirconia-reinforced gi was recently introduced. it is claimed to serve as a long-term temporary restoration until a more permanent restoration is placed


Eligibility criteria:
inclusion criteria: * children free from any systemic disease (asa i). * cooperative children showing positive or definitely positive behavior according to frankl rating scale * hypomineralized first permanent molars that are restorable according to mih treatment need index (mih-tni): index (2a), (2b), (4a), (4b) * teeth with dentinal lesions corresponding to icdas ii score 5 or 6 * no clinical or radiographic evidence of pulpal involvement. exclusion criteria: * index (0), (1), (2c), (3), (4c) on the mih treatment need index. * patients whose parents will not give their consent to participate in the study * non-restorable first permanent molars indicated for extraction
neovascularization embolisation for knee osteoarthritis.(neo)

Conditions: Osteoarthritis, Knee

Summary: in this double blind randomized sham controlled study the investigators want to establish the efficacy of transcatheter arterial embolization of neovessels for patients with symptomatic mild to moderate knee osteoarthritis after 4 months compared to a sham-embolization.

rationale: transcatheter arterial embolization has recently been proposed as an efficacious therapy for therapy-resistant osteoarthritis of the knee, providing substantial pain reduction at short-term as well as long-term follow-up up till 4 years. a potential working mechanism of treatment effect is that the normalization of the amount of blood vessels and blood flow achieved by embolization reduces inflammation, resulting in pain reduction objective: the main objective is to assess whether transcatheter arterial embolization of neovessels in patients with symptomatic knee oa results in significant pain reduction after 4 months compared to sham treatment. the investigators hypothesize that novel transcatheter arterial embolization of neovessels is a feasible, effective, and safe treatment for patients with symptomatic radiographic knee oa, resulting in significant improvement of pain symptoms in a period of 4 months follow-up compared to sham embolization. secondary objectives are 1. to assess whether reduction of neovessels is related to pain relief, 2. to explore whether decrease of inflammation is a mediating factor between neovessel reduction and pain relief, 3. to assess whether transcatheter arterial embolization reduction of neovessels decreases peripheral and central pain sensitization and 4. to assess whether transcatheter arterial embolization improve the outcome at 1, 4, 8 and 12 months compared to placebo of the: icoap, paindetect, eq-5d-5l questionnaires and nrs for pain.

Eligibility criteria:
inclusion criteria: * age.≥18 years * knee pain for a duration of ≥ 6 months * knee pain (numeric rating scale ≥4 - ≤8) on at least half of the days in the preceding month at time of inclusion. * there is insufficient response of conservative treatment for at least 6 months * radiographic knee osteoarthritis (radiographic kellgren and lawrence grade 1-3) exlusion criteria: * contra-indications for mri (e.g. metallic foreign bodies, etc.) * contra-indications for angiography * renal insufficiency, checked with blood sample test (gfr \< 30 ml/min/1, 73 m2); * known allergy to contrast agents; * patient has known allergies to barium sulfate, 3-aminopropyltrialkoxysilane, polyphosphazene * women who are pregnant or lactating * intermittent claudication of affected limb * intra articular injections in the ipsilateral knee less than 6 months ago * on the waiting list for joint replacement surgery * amitriptyline usage. * patient has known allergies to barium sulfate, 3-aminopropyltrialkoxysilane, polyphosphazene. * insufficient command of the dutch or english language. * legally incompetent adults.

Keywords: ranscatheter embolization osteoarthritis arterial