Kornimate/medical-research-clean huggingface dataset:
mobile intervention for veterans with ptsd and anger

Conditions: Posttraumatic Stress Disorder; Anger

Summary: anger is the mostly commonly reported reintegration concern among combat veterans, especially those with ptsd. problematic anger is associated with significant functional impairment. in the current project, the investigators will pilot-test a newly developed mobile app, entitled mobile intervention for reducing anger (mira), among veterans with ptsd and problematic anger. the project will compare the mira app to a contact control condition. the investigators hypothesize that veterans with ptsd and problematic anger will find the mira app acceptable and will be willing to use it to reduce their anger difficulties and improve psychosocial and occupational functioning.

anger is the mostly commonly reported reintegration concern among combat veterans, especially those with ptsd. problematic anger is associated with significant functional impairment. one of the mechanisms associated with problematic anger and aggression is hostile interpretation bias, i.e., a tendency to interpret ambiguous interpersonal situations as hostile. the investigator has previously developed and piloted a computer-based interpretation bias modification intervention that successfully reduces both hostile interpretation bias and anger outcomes. in the current project, the investigators will pilot-test a mobile application version of the existing computer-based intervention, entitled mobile intervention for reducing anger (mira), among veterans with ptsd and problematic anger. the project will compare the mira app to a contact control condition to evaluate the feasibility of recruitment, randomization, and retention procedures. the investigators will also utilize psychophysiological and electronic diary monitoring to determine whether this assessment could be used as an outcome or mechanistic variable in a subsequent randomized clinical trial application focused on evaluating the efficacy of the mira intervention.

Eligibility criteria:
inclusion criteria: * veterans diagnosed with ptsd, established via the clinician-administered ptsd scale for dsm-5 (caps-5) * reporting a score of 12 on the 5-item dimensions of anger reactions scale * able to read at least 6th grade level material exclusion criteria: * expect to be unstable on their medication regimen during the study * currently in a period of active psychosis or mania * exhibit current prominent suicidal or homicidal ideation requiring immediate intervention * receiving (or plan to receive) other anger management psychotherapy or trauma-focused therapy for ptsd (i.e., prolonged exposure, cognitive processing therapy during the course of the study

Keywords: anger posttraumatic stress disorder hostile interpretation bias mhealth
interventional study of active weight management in patients with type 2 diabetes and obesity in routine clinical practice during 12 months.

Conditions: Type 2 Diabetes Mellitus (T2DM)

Summary: this study was aimed to achieve of long-term weight loss in t2dm patients by use of comprehensive lifestyle changes program, providing patients with structured diet, exercise plan, group behavioral support and group education. additionally the study was designed to establish reduction of the body weight leads to the improvement of glycemic and lipid metabolism, and also reducing blood pressure level. the study was also directed to show that lifestyle changes program in t2dm patients can lead to decreasing of hospitalization rate and healthcare consumption. in order to demonstrate a change from standard of care, data were to be collected from a parallel cohort from the same centers.

patients of active group were assigned to receive activities of the program for life style changes. patients in control group were managed in frames of routine clinical practice. no any investigational drug therapy was used.

Eligibility criteria:
inclusion criteria: * signed informed consent. written informed consent must be obtained before any assessment is performed. •≥ 18 years * type 2 diabetes * the body mass index is from 28 to 40 kg/m\^2 exclusion criteria: * pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation. * type 1 diabetes * proliferative retinopathy * renal impairment: serum creatinine \>1.5 mg/dl, creatinine clearance \< 40 ml/min and/or proteinuria * the lack of ability to perform the physical exercises due to the orthopedic or cardiovascular disorders * chronic alcoholism, acute alcoholic intoxication

Keywords: diabetes lifestyle change weight management control of glycemic in hba1c and fpg
the role of resistance exercise in chronic obstructive pulmonary disease exacerbation

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is to determine whether resistance exercise are effective in combating the decline in muscle strength during an exacerbation of chronic obstructive pulmonary disease (copd).

acute exacerbations are common in patients with copd and cause specific signs and symptoms, such as increased dyspnea, productive cough with altered sputum, and fever. with disease progression, exacerbations are frequent and have a negative impact on health related quality of life and pulmonary function as well as increase mortality. more severe exacerbations require hospitalization resulting in enormous health expenditures, severely reducing daily life activities and declining peripheral muscle strength that can be only partially reversed after 3 months. despite many features have been pointed out as responsible for the decrease in muscle strength during hospitalization, physical inactivity seems the most important. resistance training is an interesting therapeutic option to prevent and/or reverse muscular dysfunction due to immobilised in healthy subjects and stable copd patients because induces hypertrophy of type ii fibers, increases muscle strength and exercise tolerance. in addition, provokes lower dyspnea perception during effort compared with other exercise training. despite these benefits for stable copd, the impact of a resistance exercise program during hospitalization remains poorly known.

Eligibility criteria:
inclusion criteria: * patients hospitalized for exacerbation of copd exclusion criteria: * patients presenting change in mental status (confusion, lethargy or coma) * persistence or worsening in hypoxemia (pao2\<40mmhg) and/or respiratory acidosis (ph\<7.25) despite oxygen supplementation or use of non-invasive ventilation * hemodynamic instability requiring vasoactive drugs * patients transferred to icu * hospitalization lower than 5 days * diseases that prevented the exercises

Keywords: chronic obstructive pulmonary disease exacerbation resistance training muscle force
efficacy of ubiquitous sr-based memory advancement and rehabilitation training (u-smart)

Conditions: Mild Cognitive Impairment

Summary: the purpose of this study is to examine the efficacy of the ubiquitous spaced retrieval-based memory advancement and rehabilitation training (u-smart) in the elderly individuals with mild cognitive impairment (mci) by an open-label, controlled, crossover trial.

the spaced retrieval-based memory advancement and rehabilitation training (smart) which consisted of 24 one-hour face-to-face sessions (lee, park et al. 2009) was developed based on the spaced retrieval training (srt), which was effective in improving memory retention span of very mild to mild alzheimer's disease patients. the ubiquitous smart (u-smart) by transforming the current smart to a self-administered program using an application working on ipad was developed, and showed its feasibility and efficacy in the elderly individuals with mild cognitive impairment in the preliminary study. (clinicaltrials.gov id: nct01628653) to validate the efficacy of the u-smart, an open-label, controlled, crossover design of clinical trial were planned in this study.

Eligibility criteria:
inclusion criteria: * aged 55-90 * educational level above 1 year and confirmed literacy * diagnosed to mild cognitive impairment by international working group on mild cognitive impairment * clinical dementia rating (cdr) of 0 or 0.5 exclusion criteria: * diagnosed to dementia by dsm-iv * evidence of delirium, confusion * any neurological conditions causing cognitive decline such as parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus * evidence of severe cerebrovascular pathology * history of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity * history of substance abuse or dependence such as alcohol * presence of depressive symptoms that could influence cognitive function * presence of medical comorbidities that could result in cognitive decline use of medication that could influence cognitive function seriously

Keywords: mild cognitive impairment cognitive rehabilitation cognitive therapy spaced retrieval training alzheimer's disease memory enhancement u-healthcare
evaluating chronic obstructive pulmonary disease (copd) patients' treatment compliance and quality of life via telemedicine

Conditions: Telehealth; Copd

Summary: the covid-19 pandemic has disrupted the follow-up and treatment processes for patients, and telemedicine has emerged as an important alternative method. our aim was to test compare copd assessment test (cat) scores, inhaler treatment techniques and adherence between telemedicine-mediated healthcare and healthcare provided face-to-face.


Eligibility criteria:
inclusion criteria: * patients who were diagnosed with copd according to global initiative for obstructive lung disease (gold) * gold spirometric grade 3-4 * at least one hospital admission in the past year * acceptable score on the mini-mental state examination * residing in ankara * patient or caregiver must understand the process and be able to provide clear information * medical records and laboratory test results must be accessible to healthcare professionals * patient must have access to prescribed medications * comorbidities outside of the lungs are included exclusion criteria: * patients diagnosed with asthma * patients with lung cancer * patients with combined pulmonary fibrosis and emphysema * patients with active infections such as pneumonia or covid-19 * patients being followed for copd without spirometry * patients with low cognitive function as determined by the mini-mental state examination * patients who do not consent to participate in the study * patients lacking adequate social support * patients with copd grade 1-2 * patients with no hospital admissions in the past year * patients diagnosed with psychotic disorders * patients residing outside of ankara * patients enrolled in inpatient or supervised outpatient rehabilitation programs * patients unable to use telemedicine devices or without a caregiver to assist * patients and caregivers having difficulty providing information * patients without internet access or video call capabilities at home

Keywords: telemedicine copd inhaler adherence inhaler technique
14 weeks exercise training on lean women with and without pcos

Conditions: Polycystic Ovary Syndrome (PCOS)

Summary: the aim of this project is to investigate the pathophysiology of pcos in regards to the metabolic profile including defects in insulin sensitivity in skeletal muscle and adipose tissue, and to investigate the effects of exercise training on these parameters.


Eligibility criteria:
inclusion criteria: women with pcos * hyperandrogenism and/or hyperandrogenemia * regular menstruation * age: 20-40 * inactive or low physical activity level * low to moderate fitness status inclusion criteria: women without pcos * normal levels of plasma androgens * polycystic ovary and/or menstrual dysfunction * age: 20-40 * inactive or low physical activity level * low to moderate fitness status exclusion criteria: women with and without pcos * pregnancy or breast feeding * smoking * use of birth control pills 3 mo before enrolment

Keywords: polycystic ovary syndrome (pcos)
an animation- versus text-based computer-tailored game intervention to prevent alcohol consumption in adolescents

Conditions: Alcohol Drinking; Binge Drinking; Adolescent Behavior

Summary: this study consists in the design, implementation and evaluation of an animation (alerta alcohol 2.0)- versus text-based (alerta alcohol) computer-tailored game intervention aimed to prevent alcohol consumption and binge drinking (bd) in spanish adolescents. a cluster randomized controlled trial (crct) is conducted to test the effectiveness of alerta alcohol versus alerta alcohol 2.0 in students aged 14 to 19 years across 24 high schools from andalusia (southern spain), which are randomized either to the experimental (ec-1, ec-2) or the control conditions (cc).

alcohol use and misuse, and particularly, bd in adolescents are a highly prevalent healthcare problem that associates physical and mental health complications and community implications. the alerta alcohol and alerta alcohol 2.0 programs are based on the i-change model. a crct is carried out. the schools from andalusia are randomized either to the experimental (ec-1, ec-2) or the control conditions (cc). the ec-1 receives an online intervention (alerta alcohol, which has adapted from a previous version) with personalized health advice, using textual feedback and several gamification techniques, and consists of nine sessions (performing seven of them at the high school): session 1 or baseline, sessions 2 and 3 where adolescents are provided with answers related to their views to provide highly specific feedback regarding their knowledge, risk perception, self-esteem, attitude, social influence and self-efficacy; sessions 4, 5, 7 and 8 are reinforcement sessions (booster sessions) and sessions 6 and 9 are follow-up questionnaires at six and twelve months. the ec-2 receives an improved version of alerta alcohol (alerta alcohol 2.0) using animated videos and new gamification strategies. the cc just completes the baseline and the evaluation questionnaires and then they are allowed to receive the intervention as well (as a waiting list). to test the effectiveness, the primary outcome is bd within 30 days prior to evaluation and alcohol use (high-intensity drinking, weekly and any consumption) in the previous week as secondary outcomes.

Eligibility criteria:
inclusion criteria: * students aged 14 to 19 years. * enrolled in andalusian public or private high schools. * access to the internet at the schools and the use of computer, mobile or tablet is allowed. * access to the internet in their homes. exclusion criteria: * language barriers. * previous participation in prevention programs for bd.

Keywords: alcohol use binge drinking high-intensity drinking adolescents web-based interventions computer-tailoring animation
study of pazopanib and paclitaxel in advanced non-small cell lung cancer

Conditions: Lung Cancer, Non-Small Cell

Summary: the phase i part of the study will identify the doses of pazopanib and paclitaxel that can be administered safely in combination. the phase ii part of the study will not be progressed as documented in protocol amendment 01.


Eligibility criteria:
inclusion criteria: * written informed consent * at least 18 years old * histologically- or cytologically-confirmed diagnosis of stage iiibwet (with confirmed malignant pleural effusion) or stage iv nsclc (or for phase i only, advanced solid tumor for which there is no standard therapy or for whom paclitaxel is standard therapy). * no prior systemic first-line therapy for advanced disease * measurable disease * ecog performance status of 0 or 1 * life expectancy of at least 12 weeks. * able to swallow and retain oral medication * adequate organ system function (hematological, renal, and hepatic) * non-childbearing potential (i.e., physiologically incapable of becoming pregnant) or childbearing potential, and agrees to use adequate contraception exclusion criteria: * active malignancy or any malignancy in the 3 years prior to first dose of study drug other than nsclc (or for phase i, other than the primary solid tumor) * cns metastases or leptomeningeal carcinomatosis, except for asymptomatic, previously treated cns metastases * clinically significant gastrointestinal abnormalities * prolongation of corrected qt interval (qtc) \> 480 msecs * history of any one or more cardiovascular conditions within the past 6 months prior to randomization * poorly controlled hypertension * history of cerebrovascular accident (including transient ischemic attacks), pulmonary embolism or untreated deep venous thrombosis (dvt) within the past 6 months * major surgery or trauma within 28 days or any non-healing wound, fracture, or ulcer * evidence of active bleeding or bleeding diathesis * recent hemoptysis * endobronchial lesions and/or lesions infiltrating major pulmonary vessels * serious and/or unstable pre-existing medical (e.g., uncontrolled infection), psychiatric, or other condition that could interfere with subject's safety, provision of informed consent, or compliance to study procedures * use of any prohibited medication * use of an investigational agent within 28 days or 5 half-lives, whichever is longer, prior to the first dose of study drug * ongoing toxicity from prior anti-cancer therapy that is \>grade 1 and/or that is progressing in severity except alopecia * known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib, paclitaxel, and/or carboplatin.

Keywords: paclitaxel nsclc pazopanib advanced non-small cell lung cancer non-small cell lung cancer advanced solid tumor gw786034 metastatic non-small cell lung cancer
comparison of efficacy of iron polymaltose complex and ferrous sulphate in iron deficiency anemia in pediatric patients

Conditions: Iron Deficiency Anemia; Iron Deficiency, Anaemia in Children

Summary: this study aims to compare the efficacy of two iron preparation for the management of children presented with iron deficiency anemia. ferrous sulphate and lron polymaltose (ferric form) are most commonly used preparations. both drugs are easily available in market and are often recommended by pediatriclans. the efficacy, bioavail.tbilily, side effects and cost of these preparations vary. this study is designed to find out a drug with better efficacy that can be used for treatment of iron deficiency anemia in local population.

anemia remains a condition with high prevalence in populations worldwide. it is predominantly associated with nutritional status and socioeconomic conditions or hereditary diseases. the majority of anemia cases are linked to iron deficiency-named iron-deficiency anemia resulting from low intake of iron-rich foods in the diet, or from substantial blood loss. this study aims to compare the efficacy of two iron preparation for the management of children presented with iron deficiency anemia. ferrous sulphate and lron polymaltose (ferric form) are most commonly used preparations. both drugs are easily available in market and are often recommended by pediatriclans. the efficacy, bioavail.tbilily, side effects and cost of these preparations vary. this study is designed to find out a drug with better efficacy that can be used for treatment of iron deficiency anemia in local population.

Eligibility criteria:
inclusion criteria: * patients having iron deficiency anemia exclusion criteria: 1. patients diagnosed as congenital aplastic anemia or thalassemia (determined from medical record). 2. patients who were transfused in previous 4 weeks (will be determined on history) 3. children having mal-absorption syndrome and diarrheal illnesses. (will be determined on history and medical record) 4. gastrointestinal bleeding suggested by history of hematemesis (bloody vomit), melena (black colored stools) or bloody stools.

Keywords: iron polmaltose complex ferrous sulphate iron deficiency, anaemia in children
predictive models for intensive care admission and death of covid-19

Conditions: COVID19; Pneumonia, Viral; Inflammatory Response

Summary: to build simple and reliable predictive scores for intensive care admissions and deaths in covid19 patients. these scores adhere to the tripod (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) reporting guidelines. the outcomes of the study are (i) admission in the intensive care unit admission and (ii) death. all patients admitted in the emergency department with a positive reverse transcription-polymerase chain reaction sars-cov2 test were included in the study. routine clinical and laboratory data were collected at their admission and during their stay. chest x-rays and ct-scans were performed and analyzed by a senior radiologist. generalized linear models using a binomial distribution with a logit link function (r software version x) were used to develop predictive scores for (i) admission to icu among emergency ward patients; (ii) death among icu patients. a first panel of number models with the highest aic (bic) was preselected. ten-fold cross-validation was then used to estimate the out-of-sample prediction error among these preselected models. the one with the smallest prediction error was in the end singled out .


Eligibility criteria:
inclusion criteria: * rt-pcr + sars cov2 pneumonia exclusion criteria: * \< 18 ans -\* gold 3 or 4 cpod

Keywords: covid19, prediction scores, icu admission, death, tripod.
neuropathy in patients monitored for wild-type ttr cardiac amyloidosis (non-mutated)

Conditions: Wild-type Amyloid Cardiopathy

Summary: transthyretin (ttr) amyloidosis is a rare disabling disorder that can be hereditary or sporadic. depending on the form, various tissues are affected. while in hereditary cases, neuropathy is predominant, cardiac impairment is the main manifestation in the sporadic form. the main objective of this project is to evaluate the proportion of patients with neuropathy in a population of patients with a non-mutated ttr amyloid cardiopathy condition.

transthyretin (ttr) amyloidosis belongs to a group of severe and multi-systemic diseases caused by an extracellular accumulation of fibrillar proteins arranged in beta-pleated sheets. this pathology can be hereditary (mutations in the ttr gene) or sporadic. depending on the form, various tissues are affected: peripheral nervous system (leading to neuropathy, especially vegetative), heart, kidney... while in forms linked to ttr mutations neuropathy is the main manifestation, in the sporadic form (also called wild-type), the cardiac impairment is predominant. other organ damages are rarely reported in this second form. in the thaos registry (coelho t. et al, 2013), a clinical peripheral neuropathy is reported in 28.4% out of 67 patients with the sporadic form of the disease, although the authors do not provide a precise description of the neuropathy type. we propose to prospectively study patients with a wild-type amyloid cardiopathy condition to identify and describe the associated neuropathy. a pilot study conducted at the bordeaux university hospital demonstrated the feasibility and interest of this research: it showed the presence of an undetermined aetiology polyneuropathy in 35.7% out of 14 patients followed for senile cardiac amyloidosis. tafamidis is used on familial amyloid neuropathy and a recent study shows an effect on senile amyloid cardiopathy (maurer ms et al., 2018) which strengthens the need to determine the frequency of neuropathies associated with wild-type amyloid cardiopathy and to type them more accurately.

Eligibility criteria:
inclusion criteria: * patients of both gender, over 18 years old, with transthyretin amyloid cardiopathy according to one of the two american heart association definitions of 2016 * no mutation in the ttr gene * patients giving their free and informed consent to participate after information about the research * patients affiliated to or benefiting from a social security scheme exclusion criteria: * patients with chronic neuropathy related to a known aetiology * patients under guardianship or curatorship

Keywords: wild-type amyloid cardiopathy neuropathy descriptive study