Kornimate/medical-research-clean huggingface dataset:
effectiveness of a community health worker delivered care intervention for hypertension control in uganda

Conditions: Hypertension; Community Health Workers

Summary: over 80% of the morbidity and mortality related to non-communicable diseases (ncds) occurs in low-income and middle-income countries (lmics). community health workers (chws) may improve disease control and medication adherence among patients with ncds in lmics, but data are scarce, particularly in sub-saharan african settings. in uganda, and the majority of lmics, management of uncontrolled blood pressure remains limited in constrained health systems. intervening at the primary care level, using chws to improve medical treatment outcomes has not been well studied. the investigators aim to determine the effectiveness of a chw-led intervention in blood pressure control among confirmed hypertensive patients and patient-related factors associated with uncontrolled hypertension. methods: conduction of a stepped-wedge cluster randomized controlled trial study of 869 adult patients with hypertension attending two ncd clinics to test the effectiveness, acceptability and fidelity of a chw-led intervention. the multi-component intervention will be centered on monthly household visits by trained chws for a period of seven months, consisting of the following; (1) blood pressure and sugar monitoring; (2) bmi monitoring; (3) cardiovascular disease risk assessment; (4) using checklists to guide monitoring and referral to clinics; (5) healthy lifestyle counselling and education. during home visits, chws will remind patients of follow-up visits. the investigators will measure blood pressure at baseline and 3-monthly for the entire cohort. the investigators will additionally test acceptability of the intervention and fidelity over the course of the intervention. the investigators will conduct individual-level mixed effects analyses of study data, adjusting for time and clustering by patient and community. conclusion: the results of this study will inform community delivered hypertension management across a range of lmic settings.


Eligibility criteria:
inclusion criteria: * participants with hypertension (systolic \>140 and/or diastolic \>90) * participants attending the two ncd clinics * adults 18 years and above * participants residing in the three sub counties (nakaseke town council, nakaseke sub county and kasangombe of nakaseke district) * participants able to give informed consent. exclusion criteria: * patients diagnosed with hypertension but already controlled * pregnant women * patients with an expected life expectancy of less than one year

Keywords: hypertension community health workers uncontrolled blood pressure uganda
the correlation between the length of stay in post acute care(pac) and general improvements in stroke patients

Conditions: Stroke

Summary: post-acute care(pac) had been inaugurated in taiwan for almost four years and current essays revealed positive effects upon general improvements in stroke patient after pac training. during acute phase, a stroke patient would admit to internal medicine or surgical ward and transferred to rehabilitative ward for more intensive therapeutic programs, restoring muscle power and promoting activity of daily life(adl) ability. under relative stable condition, the patient would transfer to pac institution or hospitals afterwards for continuing rehabilitative program if the patient is acknowledged to have rehabilitative potentials. however, there's still lacking of investigation upon whether the length of stay in pac correlates to general improvements. thus, stroke patients' functional ability, such as activities of daily living (adl) function, swallowing ability and so on, as well as their corresponding scales were assessed on the first and last day during pac hospitalization. statistical analysis was conducted via spss ver21.0 to compare the relationship of improvements in functional ability and the length of stay in pac. we're looking forward to the final results!

functional ability in stroke patients are evaluated by following measurements. activity of daily life (adl) function was estimated through modified rankin scale(mrs) and barthel index(bi), swallowing ability by functional oral intake scale, nutritional status via mini nutritional assessment, life quality through euroqol-5d, instrumental adl function by lawton-brody iadl scale(iadl), balance/coordination via berg balance test, walking speed through usual gait speed, cardiopulmonary capability by six-minute walk test, occupational mobility (amount use/quality) via motor activity log, language through concise chinese aphasia test, motor function of upper extremities by fugl-meyer assessment and so on.

Eligibility criteria:
inclusion criteria: * \>18 y/o * acute onset of stroke within 30 days * modified rankin scale 2\~4 exclusion criteria: * patients refused to join post acute care(pac) program * hemodynamic unstable * disease progression
effects of resistance training in elderly

Conditions: Aging Disorder

Summary: this comes from a non-randomized clinical trial, which aims to check on elderly women the effects of a program of resistance training (tr) in physical performance, in respiratory functional capacity, on health and quality of life.

will be measured the strength of the respiratory muscles (mip and mep), peak expiratory flow (peak-flow), thoracic movements and abdominal movements, distance traveled in incremental shuttle walk test, grip strength manual, pulmonary leukocytes, biochemical parameters and indicators of quality of life and physical activity through the whoqol-old and ipaq-short. the data will be tested against the distribution of the gauss curve, by the shapiro-wilk test and, if they have a normal distribution (parametric) are expressed as mean and standard deviation, if not submit normal (non parametric) distribution will be expressed as median or range interquartílico. the first chance to compare the evolution of the group studied, will be applied to two-way anova. if the distribution is abnormal, it will apply mann-whitney test. the multiple regression test will be used to compare the mip and mep with variables with the peak-flow, thoracoabdominal mobility, distance traveled, immune competence, physical fitness and quality of life in the groups studied.

Eligibility criteria:
inclusion criteria: * 60 year old or more * do not have cardiac or respiratory diseases * neurological, musculoskeletal and other diseases preventing the practice of exercises * not being a smoker; agree to participate in the study and signed an informed consent (ic); in the last six months preceding the evaluation did not have participated in physical activity program with the aim of improving physical performance. exclusion criteria: * difficult to complete the tasks * acute diseases * refuse to continue the program

Keywords: respiratory performance quality of life physical performance
a pilot study of psychodynamic psychotherapy for bipolar disorder

Conditions: Bipolar Disorder

Summary: the purpose of this study was to compare a group psychotherapy intervention, the integrative outpatient model, to a convenience control, in adults with bipolar disorder.

the psychotherapy literature suggests that psychological treatments can have a significant impact on the clinical course and outcome for bipolar disorder (swartz \& frank, 2001). very few outcome studies have been conducted in group psychotherapy for bipolar disorder, and there are no preliminary studies conducted using the integrative outpatient model, developed specifically for bipolar disorder. given the lack of preliminary data, a pilot study with a matched-control design is indicated to obtain preliminary data regarding this treatment modality and approach. the iom is a weekly, long term psychotherapy. comparison: individuals who participate in group psychotherapy will be compared to a control group on mood and symptom ratings, up to 1 year post intervention.

Eligibility criteria:
inclusion criteria:bipolar disorder; functioning level appropriate for outpatient group psychotherapy; willingness to engage in a psychotherapeutic intervention - exclusion criteria: cognitive impairment; prominent psychosis; under 18 years old -

Keywords: psychotherapy bipolar disorder psychodynamic psychoeducation illness management controlled trial pilot study
effect of an online self-help psychological intervention on non-icu specialty care during the covid-19 outbreak

Conditions: SARS-CoV-2 Infection; Staff Attitude; Anxiety; Mental Health Issue

Summary: timely interventions may reduce the occurrence of post-traumatic stress disorder (ptsd) in icu medical staff. existing research suggests that either self-learning psychological relief methods or seeking online counseling or therapy from professional psychotherapists during the sars-cov-2 omicron outbreak has the potential to alleviate the emotional distress and promote the physical and mental health of health care workers. web-based online mental health interventions complemented by joint effective mental health advice can further reduce harmful negative effects.


Eligibility criteria:
inclusion criteria: 1. age 18 years or older 2. non-icu professional staff providing direct health care services to critically ill sars-cov-2 omicron patients in the icu 3. signing the informed consent form exclusion criteria: 1. no reported acute suicidal tendencies 2. no history of psychotic or dissociative symptoms 3. pregnancy or lactation 4. major family changes within the last 12 weeks( for e.g. death of immediate family member) 5. participated in other clinical trials
cardiovascular risk markers in spinal cord injured subjects of the wheelchair dancer study

Conditions: SCI - Spinal Cord Injury; Cardiovascular Risk Factor

Summary: the present study will analyze if exercise is able to elicit the well-known anti-atherogenic effects in patients with sci. this will be evaluated by measuring vascular parameters such as endothelial and inflammatory blood markers, echocardiography of the heart and peripheral vessels, as well as blood pressure and arterial stiffness, in subjects performing either wheelchair dancing, wheelchair marathon or no sports. further, it will be investigated, whether there is an association between neuroplasticity and cardiovascular health, as measured by electroencephalography (eeg), transcranial magnetic stimulation (tms) and blood levels of the brain-derived neurotrophic factor (bdnf). we hypothesize that the cardiovascular, physical and psychological benefits of wheelchair dancing and/or wheelchair marathon parallel improved neuroplasticity in sci-patients


Eligibility criteria:
inclusion criteria: wheelchair users independent of the cause of the walking impairment, preferably with spinal cord injury. exclusion criteria: metallic implanters, additional neurologic pathologies, pregnancy
ultrasound-guided intercostal nerve block for postoperative pain relief in percutaneous nephrolitotomy

Conditions: Nerve Block, Intercostal Nerve

Summary: percutaneous nephrolitotomy (pcnl)is an endourological procedure for the management of patients with renal calculi. postoperative pain around the surgical area and the nephrostomy tube can being a problem. we hypothesized that intercostal nerve block at 11th and 12th rib level would alleviate postoperative pain and reduce analgesic consumption.

patients admitted for the removal of renal stones by pcnl will included in this study.primary outcome measure will be analgesic (tramadol )consumption and visual analog scale (vas).

Eligibility criteria:
inclusion criteria: * patients admitted for the removal of renal stones by percutaneous * nephrolithotomy (pcnl) * asa i-ii status exclusion criteria: * respiratory or cardiac disfunction * neuropathy * coagulopathy * bmi (body mass index)over 30

Keywords: percutanous nephrolitotomy,intercostal nerve block, ultrasound
dispensing study for the phenacite project

Conditions: Ametropia

Summary: dispensing study for the phenacite project. the investigational test lens was not the final optical design and the study was not used for design validation.

evaluate the objective and patient-reported visual acceptability of the phenacite contact lens.

Eligibility criteria:
inclusion criteria: * oculo-visual examination in the last two years * between 18 and 35 years of age and has full legal capacity to volunteer * has read and understood the informed consent letter * is willing and able to follow instructions and maintain the appointment schedule * is correctable to a visual acuity of 20/25 or better (in each eye) with their habitual correction or 20/20 best corrected * currently wears, or has previously successfully worn, soft contact lenses between -1.00d and -4.00d * spherical contact lens rx between -1.00 and -4.00 and spectacle cylinder ≤-0.75 * has not worn lenses for at least 12 hours before the initial visit * has a subjective response at baseline, which indicates suitability for this study * currently spends a minimum of 4 hours a day; 5 days a week on digital devices and can replicate this time during the study period * is willing and able to wear the study contact lenses a minimum of 10 hours per day; 5 days a week. exclusion criteria: * has never worn contact lenses before * any systemic disease affecting ocular health * is using any systemic or topical medications that will affect ocular health * has known sensitivity to the diagnostic pharmaceuticals or study products used in this study. * has any ocular pathology or anomaly that would affect the wearing of the lenses * has persistent, clinically significant corneal or conjunctival staining using sodium fluorescein dye * is aphakic * has anisometropia of \>1.00 * has undergone corneal refractive surgery * has strabismus * has any ocular amblyopia \>= 1line of hc visual acuity * is participating in any other type of eye related clinical or research study * has participated in study cv-14-32.
treatment of radiation-induced fibrosis in the upper aerodigestive tract cancer by a combination of pentoxifylline-tocopherol and hyperbaric oxygen

Conditions: Fibrosis

Summary: the pentoxifylline used with tocopherol achieves a certain effectiveness in the treatment of the fibrosis. hyperbaric oxygen therapy has been recommended and used in a wide variety of medical conditions including the treatment of delayed radiation injuries (soft tissue and bony radiation necrosis). the hyperbaric oxygen therapy increases the formation of granulation tissue and produces angiogenesis maintained after use.

patients with head and neck tumors often present superficial radiation induced fibrosis and other late complications of radiotherapy that can seriously affect their quality of life. the pentoxifylline used with tocopherol achieves a certain effectiveness in the treatment of the fibrosis. hyperbaric oxygen therapy has been recommended and used in a wide variety of medical conditions including the treatment of delayed radiation injuries (soft tissue and bony radiation necrosis). the hyperbaric oxygen therapy increases the formation of granulation tissue and produces angiogenesis maintained after use. both treatments in combination could produce a synergistic effect because the angiogenesis induced by hyperbaric oxygen therapy allow better access to drugs to the injury. the magnetic resonance, provides data of the fibrosis and other side effects of radiotherapy.

Eligibility criteria:
inclusion criteria: 1. over 18 years and under 70 years old. 2. patients who have received radiotherapy after being diagnosed with cancer of upper aerodigestive tract, and have skin toxicity grade ii or higher. 3. follow-up for at least a year after the radiation treatment is completed. 4. absence of tumor at the time of recruitment. 5. patients with the capacity to give informed consent exclusion criteria: 1. allergy or hypersensitivity to pentoxifylline or others xanthines, or to tocopherol (vitamin e). 2. patients taking oral anticoagulants (acenocoumarol, warfarin). 3. known hemorrhagic/coagulation disorder. 4. vitamin k deficiency due to any cause. 5. use of estrogens oral contraceptives. 6. serious bleeding or extensive retinal hemorrhage. 7. ischaemic heart diseases, including recent myocardial infarction. 8. serious cardiac arrhythmia. 9. severe liver disease. 10. severe renal failure (creatinine clearance \<30 ml/min). 11. hypotension. 12. patients with metal objects or electronic devices such as cardiac pacemakers, artificial heart valves or cochlear implants, or any other contraindication for mri 13. contraindication for hyperbaric oxygen therapy. 14. patients with mobility problems. 15. female patients who are pregnant or lactating 16. any other situation or condition that, in the opinion of the investigator, may interfere with optimal participation in the study.
cancer risk assessment in patients with a constitutional alteration of the pten gene

Conditions: PTEN Gene Mutation

Summary: this is a multicentric, observational, retrospective and prospective study, aiming to estimate the risk of cancer occurrence in subjects carrying a pten mutation, based on the constitution of a national cohort.

after collection of the non objection and verification of the eligibility criteria, a first clinical questionnaire will be completed by the participant and the prescribing physician to collect the main medical events including the history of malignant tumor pathologies until the date of inclusion in the study. thereafter, an annual questionnaire will be sent to the participants to update the elements related to a tumor pathology. for the case of patients who have died or been lost to follow-up, only the information from the first clinical questionnaire will be collected from the data available from the prescribing physician without informing the relatives. however, the investigating center will have to check that these patients have not objected, during their lifetime, to the use of their data.

Eligibility criteria:
inclusion criteria: 1. male or female. 2. adult or child without age limit. 3. carrier of a constitutional or mosaic alteration of the pten gene established and/or confirmed by the institut bergonié's genetics laboratory, following a request for molecular diagnosis made between 1997 and 2027. 4. participant informed of his genetic diagnosis. 5. participant informed and not having expressed non-opposition to participate in the research. 6. participant affiliated to a french social security system in accordance with french law on research involving the human person. exclusion criteria: 1. participant under guardianship or curatorship. exception: a participant with autism may be included in the study. 2. persons deprived of their liberty by a judicial or administrative decision. 3. persons under psychiatric care, persons admitted to a health or social establishment for purposes other than research; exception: a participant with autism may be included in the study.

Keywords: pten gene mutation risk of cancer occurence
a study based on data from german sick funds that looks at the costs of treatment of type-2 diabetic patients with empagliflozin vs. dpp-4 inhibitors vs. glp-1 receptor agonists

Conditions: Diabetes Mellitus, Type 2

Summary: empagliflozin vs. dipeptidyl peptidase 4 (dpp-4) inhibitors and glucagon-like peptide-1 receptor agonists (glp-1-ra) cost of care study: a german claims data analysis


Eligibility criteria:
inclusion criteria: * continuous insurance by the sickness fund for the entire period (01/01/2014 - 31/12/2018; death of a patient is the only accepted exception from this rule) * at least two outpatient t2dm diagnoses (icd e11.-) in two different quarters and/or at least one inpatient t2dm diagnosis (icd e11.-) in the period 01/01/2014 to 31/12/2016, but before or on index date (i.e. first empagliflozin or dpp-4i /sitagliptin prescription). * at least one prescription of empagliflozin or a dpp-4i /sitagliptin in the inclusion period (01/01/2015 - 31/12/2016) exclusion criteria: * at least one prescription of a sodium glucose transporter 2 inhibitor (sglt-2i), dpp-4i or glp-1-ra in the baseline period (01/01/2014 - 31/12/2014) * during follow-up, patients will be censored if they switch to any sglt-2i, dpp-4i or glp-1-ra or initiate a concomitant use of any sglt-2i, dpp-4i or glp-1-ra (free or fixed-dose combinations).
study to investigate tolerability and efficacy of mk5172 / mk8742 without ribavirin for 12 weeks in patients with chronic hcv g1b infection with compensated cirrhosis

Conditions: Hepatitis C; Compensated Cirrhosis

Summary: to assess efficacy (svr rate) of mk5172 / mk8742 for 12 weeks without rbv in g1b patients with compensated cirrhosis (child-pugh a5 to a6) previously failing first gen. pi or non responders to pr.


Eligibility criteria:
inclusion criteria: 1. informed consent form signed, 2. age \> 18 years, 3. chronic infection with hepatitis c virus genotype 1b, 4. hcv rna \> 100 iu/ml, 5. hcv patients previously treated by pr with no response or previously treated with first generation pis (boceprevir, telaprevir, simeprevir) and failing therapy, 6. subjects with compensated cirrhosis with child-pugh score ranging between a5 to a6. cirrhosis defined by liver biopsy (metavir f4) or non-invasive methods (transient elastography (fibroscan) \> 12.5 kpa; or fibrotest or fibrosure \> 0.75 with apri \>2), 7. hepatic venous pressure gradient (hvpg) \> 6 mmhg (only in selected sites), 8. albumin level ≥ 3.0 g/dl, 9. platelet count ≥ 75 x 103/μl. exclusion criteria: 1. child-pugh score greater than cp-a6, 2. patients with hcv genotype 1a, 2, 3, 4, 5, 6, 3. have any serious or active medical illness which, in the opinion of the investigator, would interfere with subject treatment, assessment, or compliance, 4. hiv or chronic hepatitis b virus (hbv) infection (hbsag positive), 5. decompensated cirrhosis/previous decompensation, 6. pregnancy, 7. breast-feeding, 8. known hypersensitivity to grazoprevir, elbasvir or any of its components, 9. albumin level \< 3.0 g/dl, 10. platelet count \< 75 x 103/μl, 11. concomitant participation in any clinical trial.
exacerbating factors in inflammatory bowel disease

Conditions: Ulcerative Colitis; Crohn's Disease

Summary: cross-sectional study of potential triggers for flares of crohn's disease or ulcerative colitis.

detailed questionnaires with patient in regards to potential triggers for flares of ibd. includes both patients with flares and those in remission as a control group.

Eligibility criteria:
inclusion criteria: * history of verified crohn's disease or ulcerative colitis exclusion criteria: * unwilling to participate