Kornimate/medical-research-clean huggingface dataset:
an observational study of bevacizumab in combination with 5-fu-based chemotherapy in chinese participants with metastatic colorectal cancer

Conditions: Colorectal Cancer

Summary: this observational study will evaluate the safety and efficacy of bevacizumab in combination with 5-fluorouracil based chemotherapy as first-line and second-line therapy in chinese participants with metastatic colorectal cancer. data will be collected from each participant for up to 3 years.


Eligibility criteria:
inclusion criteria: * adult chinese participants, \>/= 18 years of age * histologically confirmed and previously untreated metastatic colorectal cancer * initiated on treatment with bevacizumab (in combination with 5-fu based chemotherapy) according to locally approved bevacizumab china package insert * documented participant with medical records exclusion criteria: * recent history of serious hemorrhage or hemoptysis of \>/= 1/2 teaspoon of red blood * proteinuria at baseline (\>/=2 grams / 24 hours) * major surgical procedure within 28 days prior to study treatment start, not fully healed wounds * pregnant or lactating women
trends of the pre-hospital emergency care spectrum in beijing from 2005 to 2014: a retrospective analysis

Conditions: Emergencies [Disease/Finding]

Summary: this was a retrospective analysis of a cohort of all emergency care patients in beijing from january 2005 to december 2014. this aim of this study was to analyze the trends in pre-hospital emergency care need and the emergency response times, with the intention of aiding the government to optimize medical resources and improve pre-hospital emergency care.

pre-hospital emergency care is a very important part of emergency medical service (ems) system, crucial to patients' life support, disability and mortality rate reduction. the level of pre-hospital emergency care reflects the comprehensive ability of the organizational, management and public welfare of a country. beijing emergency center and beijing red cross emergency center are in the charge of all the pre-hospital emergency care in beijing, which respectively subordinate to beijing government and chinese red cross society. this study collected the data of 3,909,746 cases from these two pre-hospital care centers from january, 2005 to december, 2014 and retrospective analyzed the pre-hospital emergency call demand and first aid related time. the results of this study can help the government optimize medical resources; strengthen the prevention of related emergency diseases. the changes and trends of pre-hospital care disease spectrum also present the same problems and situation of developing megacities like beijing. based on the meticulous work in these 2 centers, this study has collected the most complete pre-hospital emergency care data in china.

Eligibility criteria:
inclusion criteria: * all patients treated by pre-hospital care from the beijing emergency medical center and beijing red cross emergency center from january 2005 to december 2014 exclusion criteria: * missing data * duplicate records * no identifiable chief cause cases * not emergency cases

Keywords: pre-hospital care diseases spectrum call demands emergency response time
analysis of early healing of sutures in periodontal surgery

Conditions: Post-Surgical Complication; Periodontal Inflammation; Surgical Site Infection

Summary: the main objective is to analyze post-surgical periodontal healing after conventional periodontal surgery where an absorbable suture coated with clorhexidine (novosyn clorhexidine) versus conventional sutures without chlorhexidine (novosyn) will be used a pilot randomized clinical study has been designed. up to authors´ knowledge until now there are no studies to evaluate periodontal healing after periodontal surgery in combination with this kind of sutures.

a total of 60 patients will be included, where the unit of study will be each stitch, among the patients attending the dental clinic service of the university of the basque country (upv/ehu) who require surgical periodontal treatment. the patients will be randomly divided into two groups: the control group using a conventional suture (n=30), and the test group using a suture coated with chlorhexidine diacetate (n=30). suture in the control group: absorbable suture of polyglactin 910 coated with polyglactin 370 + calcium stearate without chlorhexidine (novosyn) suture in the test group: absorbable suture of polyglactin 910 coated with polyglactin 370 + calcium stearate and chlorhexidine diacetate (novosyn chlorhexidine) the primary variable in this study is post-surgical healing in both groups, which will be assessed using the healing index.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years-old * patients who have completed the basic periodontal phase and require surgical periodontal treatment for periodontal disease control. * plaque index (o'leary et al.,1972) ≤20%. * bleeding index (ainamo \& bay,1975) ≤20%. exclusion criteria: * patients with systemic conditions contraindicating surgery * patients with allergy to chlorhexidine and/or o-cymen-5-ol * patients allergic to non-steroidal anti-inflammatory drugs (nsaids) * pregnant or breastfeeding women * patients with periodontal defects requiring regenerative surgery or mucogingival surgery/periodontal plastic therapy * patients who have taken antibiotics in the last 3months

Keywords: surgical site infection periodontal surgery post-surgical pain post-surgical inflammation periodontitis
acupuncture for primary sjögren syndrome

Conditions: Sjogren's Syndrome

Summary: the purpose of this study is to determine whether acupuncture is effective and safe in the treatment of primary sjögren syndrome.

this randomized, double-blinded, sham acupuncture controlled trial is aimed to assess the effectiveness and safety of acupuncture in the treatment of primary sjögren syndrome.the eligible participants will be randomly allocated to receive acupuncture or sham acupuncture for 8 weeks. assuming a two-sided alpha of 0.05, power of 85%, and a 20% drop-out, a sample sized of 30 would be needed for each group. the statistical analysis will be based on the intention-to-treat principle. continuous variables will be compared by student t test or mann-whitney u test; categorical variables will be analyzed by chi-square test, fisher's exact test or kruskal-wallis h test as appropriate. for comparison between two time points, paired t-test or wilcoxon signed rank test will be used as appropriate. a statistically significant difference was set at p\<0.05.

Eligibility criteria:
inclusion criteria: * to fulfill the american-european consensus group criteria for primary sjögren syndrome. * with the symptoms of primary sjögren syndrome less than 5 years. exclusion criteria: * with an acupuncture contraindication (allergy to metals, skin lesions on relative acupoints, etc.) * taking or taken medicine for primary sjögren syndrome within last 4 weeks before the enrollment.
acoart ⅱ/ btk china: drug-eluting balloon for below-the-knee angioplasty evaluation in china

Conditions: Peripheral Artery Disease

Summary: the purpose of this study is to determine whether deb is more effective than common pta balloon using under in long-term vessel patency and inhibiting restenosis in the infrapopliteal artery.

pta is an established alternative to open surgical bypass for the treatment of infrainginual disease of critical limb ischemia. debs are designed to promote arterial patency by reducing neointimal proliferation.

Eligibility criteria:
inclusion criteria: * age between 18 and 85 years * patients with peripheral artery disease (pad), with rutherford classification between 4 and 6 * an occlusion or a minimum grade of stenosis primary over 70% in the below popliteal artery * the expected survival time is more than 1 year * signed patient informed consent form exclusion criteria: * serum creatinine clearance rate less than 30ml/min in patients * patients with acute thrombosis requiring lysis or thrombectomy * patient with a lysis or an lower limb intervention as a therapy within the last 6 weeks * patient requiring intervention in both lower limbs at the same time * in-stent restenosis in the blow-knee popliteal artery * target lesion can't be cross by the guide wire * the stenosis rate of proximal outflow more than 30% with or without intervention * the length of the stenosis or occlusion in proximal outflow(including the iliac artery, the superficial femoral artery, the popliteal artery) more than 150mm before intervention * stenosis or occlusion of distal outflow for below-the-ankle artery. * expected major amputations at the index limb before intervention * known hypersensitivity to aspirin, heparin, clopidogrel,paclitaxel, contrast medium, etc. * patients participating in another clinical trials with interfere with this trial in the same time * pregnancy and lactating woman * untreatable bleeding diatheses

Keywords: drug eluting balloon catheter
electronic health records for health promotion

Conditions: Influenza

Summary: the purpose of this study is to determine whether personally controlled electronic health records can be used for health promotion in a workplace setting.

in response to the call for research of the new health protection research initiative at the centers for disease control and prevention (cdc), we propose to adapt newly mature informatics technology to shift the paradigm for health alerting and health promotion in the workplace. the goal is to firmly ground these activities on real time information collected from and delivered to employees, in an interactive, secure, electronic environment. we will study influenza prevention and control, an archetype of public health practice requiring surveillance, communication, and timely influence of health-related behaviors. complex information gleaned from surveillance will be processed, translated and provided to employees. the goal is to provide employees with timely, individualized health promotion messages to improve their knowledge, attitudes and beliefs regarding influenza and to increase the rate of seasonal influenza immunization for them and their household members. the approach will be evaluated in a group randomized design at several worksites of a major corporation.

Eligibility criteria:
inclusion criteria: 1. the subject is a part-time or full-time employee at a major corporation. 2. the subject is eighteen years of age or older. 3. the subject is comfortable reading and writing in english. 4. the subject has reliable internet access at home, at school, or at work. 5. the subject uses email regularly (i.e. at least once every 2 days) 6. the subject does not have a known allergy to chicken eggs or a history of a severe reaction to an influenza vaccination in the past. exclusion criteria: -

Keywords: influenza electronic health record behavior modification
exercise effect on chemotherapy-induced neuropathic pain

Conditions: Cancer, Breast; Cancer, Colorectal; Cancer, Lung; Cancer, Ovarian

Summary: chemotherapy-induced peripheral neuropathy (cipn) continues to be a serious healthcare concern. it is painful, persistent, resistant to conventional pain therapies, and results in long-term suffering and decreased quality of life for many cancer survivors. the role of exercise to decrease cipn-related neuropathic pain (cipn-np) will be investigated, with the goal of identifying the mechanisms associated with this therapeutic approach to manage cipn-np.


Eligibility criteria:
inclusion criteria: * diagnosis with cancer, stage i-iv * history of treatment with oxaliplatin, docetaxel, or paclitaxel, either alone or in combination with other agents * completion of chemotherapy \> 6 months \< 1 year * ability to walk on a treadmill * medical clearance from oncologist or primary care provider * presence of cipn per national cancer institute common toxicity criteria grade 1-3 (0-no signs/symptoms, 1-minor loss of function, 2-increased symptoms not interfering with activities of daily living (adls), 3-severe symptoms interfering with adl, 4-disabling, and 5 is death) * score on neuropathic pain scale \>1 * age 21-70 exclusion criteria: * denial of cipn * other motor/sensory neuropathy caused by other than chemotherapy (i.e.alcohol-related, autoimmune diseases, diabetes) * coronary artery disease * history of \>1 chemotherapy regimen * musculoskeletal conditions which preclude participation in an exercise training program * pregnancy * regular exerciser, defined as \>90 minutes per week of aerobic exercise and any resistive training

Keywords: exercise neuropathy
trial of acquired haemophilia with steroid combined with cyclophosphamide versus steroid combined with rituximab

Conditions: Acquired Hemophilia A

Summary: purpose: to evaluate the efficacy when administering steroid combined with single dose rituximab to eliminate the antibody in acquired hemophilia a patients compared to treatment using steroid with cyclophosphamide. the study will test the hypothesis that steroid combined with small dose rituximab is as effective as steroid combined with cyclophosphamide for fviii inhibitor eradication in chinese patients with acquired hemophilia a. study design allocation: randomized intervention model: parallel assignment masking: none (open label) primary purpose: treatment

this is a prospective randomized multi-center controlled pilot trial comparing the regimen of steroid with rituximab and steroid with cyclophosphamide to eradicate anti-factor viii antibodies in chinese patients with acquired hemophilia a. patients will be randomized to two regimens: methylprednisolone 0.8mg/kg/day (or equivalent corticosteroid doses) for 3 weeks (then tapering gradually,8 weeks in total) with rituximab (375mg/m2 for one dose) or methylprednisolone 0.8mg/kg/day (or equivalent corticosteroid doses) for 3 weeks (then tapering gradually,8 weeks in total) with cyclophosphamide 2mg/kg/day until inhibitor negative(no longer than five weeks). patients will be randomized to the treatment cohorts according to the biostatistical methods.

Eligibility criteria:
inclusion criteria: * 18-80 years old * men or women * women post-menopausal or with ongoing contraception * diagnosis of acquired hemophilia a * patient must be insured * patient has provided written informed consent prior to enrollment * patient compliant exclusion criteria: * congenital hemophilia * ongoing treatment with prednisone \> 20mg/d （or equivalent corticosteroid doses） more than 1 month * ongoing treatment with prednisone \>0.7mg/kg（or equivalent corticosteroid doses） more than 10 days * pregnant and breastfeeding women * allergy to steroid * immunosuppressive agents treatment within 30 days * serum transaminase and bilirubin greater than 1.5 times the upper limit of normal value * hepatitis b surface antigen or hepatitis c antibody or hiv antibody (i + ii) or syphilis antibody positive * patients with diabetes, hypertension, glaucoma, peptic ulcer, herpes zoster, pulmonary infection and so on, who should not be treated with glucocorticoids * patients with poor compliance * those who can not take contraceptive measures during the test period * patient who is considered by the investigator not suitable for clinical study * thrombocytopenia * leucocytopenia

Keywords: acquired hemophilia a cyclophosphamide rituximab steroid
bilateral erector spinae plane block in paediateric cardiac surgery

Conditions: Pain Management

Summary: ultrasound guided erector spinae plane block will be done for childern under going midline sternotomy for cardiac surgery. it is a novel block which is suspected to give powerful analgesia, decrease anaesthetic consumption and decrease awareness on cardiac bypass


Eligibility criteria:
inclusion criteria: * elective surgery * childern between 4 and 10 years exclusion criteria: * emergency * infection at injection site * allergy to local anaestheics
handgrip training in patients with peripheral artery disease

Conditions: Peripheral Arterial Disease

Summary: the aim of this study is to analyze the effects of isometric handgrip training (iht) on blood pressure of hypertensive patients with peripheral arterial disease. will be recruited 30 patients which will be randomized into 2 groups (15 per group), iht and control group (cg). iht group will training isometric contraction for 12 weeks. in cg patients will be encouraged to increase the level of physical activity. in the pre and post-intervention cardiovascular measures will be obtained.

meta-analyze studies have shown that 4 sets of 2 min of isometric handgrip training (iht)reduces blood pressure (bp), reaching 10 mmhg for systolic and diastolic 7 mmhg in hypertensive patients after few weeks. however, using this protocol it was not observed any changes in bp in patients with peripheral artery disease. however, it is unknown whether reductions in bp does not occur after isometric handgrip training employing longer and protocol of iht with more volume. the aim of this study is to analyze the effects of iht on blood pressure of hypertensive patients with peripheral arterial disease. will be recruited 30 patients, which will be randomized into 2 groups (15 per group), iht and control group (cg). iht group will hold three sessions per week with eight sets of two minutes of isometric contraction at 30% of maximal voluntary contraction and interval of two minutes between them, for 12 weeks. in the cg patients will be encouraged to increase the level of physical activity. in the pre and post-intervention, bp and cardiac autonomic modulationwill be assessed. will be used to analyze two-factor variance for repeated measures, with group (iht and cg) and the time (before and after 12 weeks) as factors and the post-hoc test of newman-keuls.

Eligibility criteria:
inclusion criteria: * women in post-menopause phase without hormone replacement therapy * ankle-brachial index \<0.90 * not severe obese (≥ 35kg/m2) * not present amputation in the limbs * have blood pressure levels lower than 160mmhg for systolic and 105mmhg for diastolic exclusion criteria: * patients will only be excluded if they make any medication changes before completing the intervention period or present any health problems that prevent physical activity.
miprostate - information hub for the prostate cancer care flow

Conditions: Prostate Cancer

Summary: this is an observational cohort study with a non-concurrent comparison group evaluating the use of a digital decision support tool (miprostate/ispm) at pre-prostatectomy, multidisciplinary conferences.

in the study cohort, all clinically relevant data on patients undergoing radical prostatectomy at karolinska university hospital were registered on the platform and subsequently presented using the platform at the conferences in which a detailed treatment plan was devised for each patient.

Eligibility criteria:
inclusion criteria: * all patients planned for prostatectomy and discussed at pre-operative conference at karolinska university hospital exclusion criteria: -
three dimensional morphology of upper respiratory tract and mandibular position on obstructive sleep apnea

Conditions: Sleep Apnea, Obstructive

Summary: oral appliances, which can maintain patients' jaw forwards during sleep, become more popular in treating obstructive sleep apnea (osa). however, the exact mechanism of mandible forward on upper airway is not completely known. in this study we will use both static and dynamic mri to study the 3d morphological changes and dynamic behavior of the upper respiratory tract at different mandible posits. because in asian society non-obese osa patients are not uncommonly seen, in this study we focus only on non-obese severe osa patients.

the aim of this study is to analyze upper airway morphology changes and dynamic movement at different sections affected by mandible position by using dynamic and static magnet resonance imaging technique. the study also discusses the formation mechanism of obstructive sleep apnea syndromes and function mechanism of the oral appliance, as well as the evaluation of the clinical results of the oral appliance on non-obese male patients with severe obstructive sleep apnea in taiwan. 10 non-obese (bmi\ 30) male patients between the age of 20 to 60 and 10 gender, bmi and age matched control (ahi\<5) were recruited for this study. nine bite index were made for the different mandible positions of the subjects. upper airway was imaged by using static and dynamic mri of each subject wearing the bite index while lying on the mri scanning table. this study also measures the circumference and takes the lateral cephalometric imaging of each subject. oral appliances were made and fitted for the experimental group subjects, who wore them for three months, after which they transferred to the sleep center and underwent psg examination to evaluate therapeutic effects of the appliances.

Eligibility criteria:
inclusion criteria: * severe obstructive sleep apnea (ahi\>=30/hr) age, sex, bmi match control subject exclusion criteria: * patients were excluded when: * (1) refused to participate in this study, * (2) had severe obstructive pulmonary disease or active neurological events, * (3) enrolled in other studies at the same time
a maintenance program for the be fit employee wellness program

Conditions: Obesity; Overweight

Summary: this research study is being done: 1) to determine if the mgh be fit program helps employees to change their nutrition and exercise habits and lower their risk for chronic diseases, such as heart disease and diabetes and 2) to determine if a maintenance program following the be fit 12 week program will help employees to keep the positive health changes.

the main objectives of this trial are to determine if employees who participate in the be fit 12 week program and are randomized to a 9 month maintenance program are more likely to maintain weight loss, physical activity level, and reduction of other clinical risk factors for disease compared to the control group. secondary objectives are to determine if employees who participate in the maintenance intervention have fewer chronic diseases related to lifestyle factors and lower health care costs at 3 years.

Eligibility criteria:
inclusion criteria: * mgh (benefited) employees who enroll in the be fit program * able to commit to 1 year of active research participation exclusion criteria: * not enrolled in the be fit program * decline participation in the research study * withdrawal from the be fit 12 week program prior to completion * women who are currently pregnant or suspect they may be pregnant * plans to leave mgh within 3 months from enrolling in be fit

Keywords: worksite wellness weight loss and maintenance physical activity health and fitness interventions healthy eating weight loss maintenance programs
the factors affecting atopic dermatitis in children age 1-3

Conditions: Atopic Dermatitis

Summary: this study evaluates the influence of different triggers on atopic dermatitis manifestation in children under 3 years old.

in this study investigators evaluate the influence of atopic dermatitis triggers before labour, right after labour, in firsts weeks after labour, in first year. investigators want to find the most popular and most important factors witch provoke atopic dermatitis manifestation and comparison the results with children without atopic dermatitis but with genetic predisposition to it.

Eligibility criteria:
inclusion criteria: * children 1-3 age without rash, without atopic dermatitis * children 1-3 age with recurrent atopic dermatitis exclusion criteria: * children 1-3 age with non-specific rush * children age 1-2 with atopic dermatitis without rush during previous year

Keywords: atopic dermatitis