Kornimate/medical-research-clean huggingface dataset:
the efficacy and safety of collagen scaffold loaded with umbilical cord derived mesenchymal stem cells in infertile women with thin endometrium or endometrial scarring

Conditions: Infertility, Female; Endometrium

Summary: the purpose of the study is to evaluate the safety and effectiveness of the collagen scaffold loaded with umbilical cord derived mesenchymal stem cells (uc-mscs) in infetile women with thin endometrium or endometrial scarring.


Eligibility criteria:
inclusion criteria: 1. infertile patients with clear fertility desires 2. diagnosed with thin endometrium or endometrial scarring for whom drugs and surgical interventions were ineffective 3. 20-42 years old 4. normal ovarian function or with frozen embryos 5. willing to actively cooperate with postoperative follow-up exclusion criteria: 1. with abnormal chromosome karyotype 2. with other uterine diseases including large intramural myomas, severe endometriosis, severe adenomyosis, severe congenital uterine malformations, endometrial tuberculosis, vaginitis and endometritis 3. systemic diseases: hypertension, diabetes, and so on 4. contraindications to pregnancy 5. contraindications to hormone replacement therapy 6. medical history of pelvic tumors or receiving pelvic radiotherapy 7. involved in other clinical studies 8. unable to adhere to the follow-up

Keywords: thin endometrium infertility
a single arm pilot study to refine a novel approach to exercise promotion based on affect-regulation

Conditions: Breast Cancer

Summary: the purpose of this study is to refine the use of an affect-regulated exercise prescription for use with survivors of breast cancer.


Eligibility criteria:
inclusion criteria: * within 5 years of completing curative treatment (surgery, chemotherapy, and radiation) for stage 0-iii breast cancer * \<60 mins/week moderate-vigorous physical activity with no major changes for the past 6-months * own an android or iphone smartphone and willing to use the smartphone to complete app-based surveys during assessment periods * willing to wear the actigraph monitor during assessment periods * access to internet to complete redcap survey assessments exclusion criteria: * non-english speaking/not able to read english * evidence of major contraindications for exercise (informed by the 2020 physical activity readiness-questionnaire (par-q)+) * currently pregnant * history of severe mental illness or currently taking mood stabilizing medications (antipsychotics, anticonvulsants, or lithium) * evidence of moderate-severe depressive symptoms (indicated by a score ≥10 on patient health questionnaire-8) * evidence of moderate-severe cognitive impairment (indicated by a score \< 3 on a 6-item cognitive screener) * evidence of clinically significant substance use as indicated by a score of ≥2 on the cage-aid screener
evaluation of myocardial reperfusion after primary pci in patients with high platelet reactivity treated by cangrelor or not

Conditions: ST-elevation Myocardial Infarction

Summary: this study aims to evaluate the impact on myocardial reperfusion and residual thrombotic burden of adding cangrelor -a potent and immediate p2y12 inhibitor- to ticagrelor in primary pci patients with high on ticagrelor platelet reactivity compared to standard of care with ticagrelor alone.

despite the use of potent p2y12 inhibitor such as ticagrelor, half of the patients presented high platelet reactivity (hpr) at the time of primary percutaneous coronary intervention (pci) for st-elevation myocardial infarction (stemi). hpr has been associated with impaired myocardial reperfusion. myocardial reperfusion, assessed using myocardial blush grade, is a strong prognostic factor associated with infarct size and mortality. antiplatelet therapy intensification using a potent and immediate p2y12 inhibitor such as cangrelor according a point-of-care platelet function test has not been studied in the acute phase of stemi. this study aims to evaluate the impact on myocardial reperfusion and residual thrombotic burden of adding cangrelor to ticagrelor in primary pci patients with high on ticagrelor platelet reactivity compared to standard of care with ticagrelor alone.

Eligibility criteria:
inclusion criteria: * patient admitted for stemi within 24 hours from symptom onset * pretreated with ticagrelor, aspirin and enoxaparin (according local protocol) * successfully treated by primary pci of a native coronary culprit lesion * anatomy accessible to optical coherence tomography (oct or ofdi) exclusion criteria: * cardiogenic shock * stent restenosis or thrombosis * use of glycoprotein iib/iiia inhibitors before or during pci * known coagulation disease * high bleeding risk (thrombocytopenia \<100,000/dl, surgery \<30 days, active bleeding) * uncontrolled arterial hypertension (\>180/110 mmhg) * history of stroke (ischemic or hemorrhagic) or transient ischemic attack * known severe renal insufficiency (egfr \<30 ml/min) * oral anticoagulation
the effectiveness of physical therapy modalities in carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: carpal tunnel syndrome is considered to be the most common entrapment neuropathy. conservative treatment is recommended in the mild and moderate stage of cts. the aim of this trial is to evaluate the effectiveness of physical therapy modalities in carpal tunnel syndrome.

conservative treatment is recommended in the mild and moderate stage of cts and should involve splinting, steroid injections, oral steroids and ultrasounds . however, the results of some research studies have showed the beneficial effect of photobiomodulation as well as nerve and tendon gliding exercises in non-operative treatment . patients were divided into two groups. the one group received low-level laser therapy (lllt); the other group underwent ultrasound treatment. additionally, nerve and gliding exercises were administered in both groups. the purpose of this trial is to assess the therapeutic efficacy of ultrasound treatment and low-level laser therapy combined with nerve and tendon gliding exercises and to compare the two regimens.

Eligibility criteria:
inclusion criteria: * diagnosis of the mild or moderate stage of cts, symptom duration for more than three months and general good health exclusion criteria: * advanced cts, secondary cts, any previous surgery in the upper limb, steroid injections and any physical therapy treatment within six months prior to the study, pregnancy, cervical radiculopathy, peripheral polyneuropathy or other neurological conditions
sexual health and rehabilitation online (shareonline)

Conditions: Cancer Survivorship; Sexual Function Disturbances

Summary: shareonline is a study for young female cancer survivors that are experiencing changes in sexual health and function. the purpose of this research is to compare two brief interventions delivered by videoconference to learn if they help women effectively manage these changes and restore sexual health and functioning.

the purpose of this research is to compare two brief interventions delivered by videoconference to learn if they help women effectively manage these changes and restore sexual health and functioning. participants in this study would first complete health questionnaires and then be randomized to take part in one of two types of education sessions delivered by an instructor over videoconference: 1) group education session or 2) individual self-management session. about 56 women will receive the group education session and about 28 will receive the individual self-management session. it is expected that about 84 women will take part in this study.

Eligibility criteria:
* female cancer survivors age 19-49 * cancer diagnosis (except non-melanoma skin cancer) ≥ 1 year prior * diagnosed with first cancer ≥ age 18 * no active cancer therapy (excluding chemoprevention) in the past four months, and no further therapy planned * ability to read and write in english * bothered by significant sexual dysfunction as evidenced by a female sexual functioning index (fsfi) score of ≤26. * regular access to the internet exclusion criteria * has never been sexually active * any impairment (e.g., hearing, visual, cognitive) that interferes with the ability to complete all study procedures independently

Keywords: cancer survivorship sexual function disturbances
study of anitocabtagene-autoleucel in participants with relapsed refractory multiple myeloma

Conditions: Relapsed and Refractory Multiple Myeloma

Summary: master protocol for cell therapy, phase 1 proof-of-concept studies in relapsed and refractory multiple myeloma and includes long-term safety follow-up.


Eligibility criteria:
inclusion criteria: * relapsed and refractory multiple myeloma treated with at least 3 prior regimens of system therapy including proteosome inhibitor (pi), immunomodulatory drugs (imid), and anti-cd38 antibody (cd38mab); or has "triple-refractory" disease * documented measurable disease * adequate organ function * life expectancy \> 12 weeks, eastern cooperative group performance status 0-1 exclusion criteria: * plasma cell leukemia or history of plasma cell leukemia * patients with a history of severe hypersensitivity to dmso should be excluded * contraindication to fludarabine or cyclophosphamide * severe uncontrolled intercurrent illness (e.g., infection) or laboratory abnormalities * active central nervous system disease involvement by malignancy or active cns pathology

Keywords: bcma myeloma chimeric
a phase 3 efficacy and safety study of intra-articular cntx-4975-05 (capsaicin) vs placebo in subjects with oa knee pain

Conditions: Osteoarthritis, Knee

Summary: this is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (ia) cntx-4975-05 (capsaicin), compared to ia placebo, in subjects with chronic, moderate-to-severe osteoarthritis (oa) knee pain.


Eligibility criteria:
key inclusion criteria: * male or female subjects between 40 and 95 years of age (inclusive) at the time of the screening visit with the ability to comply with answering the electronic diary using the study-provided tablet computers. * confirmation of osteoarthritis (oa) of the knee. * confirmation of oa of the index knee. * moderate to severe pain in the index knee associated with oa must be stable for a minimum of 6 months prior to screening, as assessed by the investigator. * bmi ≤45 kg/m\^2. * must have failed 2 or more prior therapies. * females not of childbearing potential, defined as post-menopausal for at least 1 year, or surgically sterile, or practicing one of the following medically acceptable methods of birth control throughout the study period. * subject agrees to stay on their current pain medication (including over the counter (otc) medications) from the time of screening through week 12. the current pain medication must be taken only for pain in the index knee, and not for another pain indication. * subject agrees to take only the allowed rescue medications for oa knee pain of the index knee from the time of screening through study completion and agrees to use no topical medications for oa knee pain during the trial. key exclusion criteria: * joint replacement surgery of the index knee at any time, or open surgery of the index knee in the past 24 months. * prior arthroscopic surgery of the index knee within 6 months of screening. * any painful conditions of the index knee due to joint disease other than oa. * periarticular pain from any cause. * pain in the non-index knee that is \>3 on a numeric pain rating scale (nprs) (0-10) when walking or at rest. * other chronic pain anywhere in the body that requires the use of analgesic medications. * instability of the index knee. * misalignment (\>10 degrees varus or valgus) of the index knee on standing. * documented history of neuropathic arthropathy or finding of bony fragmentation in the index knee with imaging. * physical/ occupational/ chiropractic therapy for the lower extremities or acupuncture for the lower extremities within 30 days of screening, or need for such therapy during the study. * plans to have surgery, other invasive procedures, or ia injections while participating in the study. * has used topical capsaicin on the index knee within 90 days of screening. * current use of opioids for any condition other than for oa of the index knee. * corticosteroid injection into the index knee within 90 days of screening. * received ia viscosupplementation (eg, synvisc®, hyalgan®) within 90 days of screening.

Keywords: analgesic non-opioid capsaicin intra-articular osteoarthritis pain knee pain
community interventions in non-medical settings to increase informed decision making for prostate cancer screening

Conditions: Prostate Cancer

Summary: the purpose of this study is to develop and evaluate a computer-based decision aid (da) for use by men considering prostate-specific antigen (psa) screening for prostate cancer. major medical organizations recommend that men discuss the risks and benefits of this test with their physician before making the decision. this educational, interactive da will help them prepare for that discussion.

prostate cancer (cap) is a formidable public health problem in the us and in industrialized countries worldwide. methods for primary prevention of cap are unknown. as a result, early detection has become a mainstay of cancer control efforts. however, there is considerable controversy regarding the efficacy of screening in reducing disease-specific mortality. in light of this uncertainty, major medical organizations, including the national cancer institute, currently recommend that men discuss the pros and cons of cap screening and make individualized screening decisions with their health care providers. however, because of constraints on time during medical encounters, it is not always feasible for providers to engage in in-depth discussions regarding the complexities of this issue. therefore, interventions to promote informed decision-making (idm) outside of clinical settings are needed. in this study, we propose to: (1) develop an interactive computer-based decision aid (da) to promote idm for cap screening; and (2) conduct a randomized controlled worksite trial to evaluate the impact the da intervention on employed men's ability to make informed decisions regarding cap. this work is designed to be responsive to recent calls for idm interventions in community settings among diverse populations. if successful, our findings could validate the effectiveness of das to promote idm for cap and serve as a model for widespread dissemination, thus improving quality of care.

Eligibility criteria:
inclusion criteria: * worksites employing at least 100 men in target age group (45-65 years old) exclusion criteria: * worksites with high turnover * non-english speaking workers * temporary or contract workers

Keywords: computer-assisted decision making workplace screening
the effects of optimizing post-operative pain management with multi modal analgesia on immune suppression and oncologic outcome in patients undergoing laparoscopic colorectal surgery

Conditions: Laparoscopic Colorectal Resection Due to Cancer

Summary: traditionally, pain control methods based on narcotic analgesics have been used to control severe pain after surgery, but this has resulted in side effects such as vomiting, constipation, dizziness, mental confusion due to drugs, and respiratory depression. this slowed the recovery of the patient after surgery and increased the duration of hospitalization, which had a negative impact on the patient 's prognosis. in addition, research has been conducted on the use of various painkillers in a variety of ways over the past decade to reduce the dose of narcotic analgesics and to increase the effectiveness of pain control, since studies of anesthetics and narcotic analgesics have shown immunosuppressive effects. this study investigate the effect of multimodal analgesics for postoperative pain control on immune function amd prognosis in patients undergoing laparoscopic colorectal cancer resection.


Eligibility criteria:
inclusion criteria: 1. elective laparoscopic colorectal resection due to colorectal cancer 2. curative, resectable operation 3. asa classification ⅰ-ⅲ exclusion criteria: 1. elective co-operation due to distance metastasis 2. preoperative chemo/radiation therapy 3. drug allergy to opioid, tramadol, local anesthetics 4. maoi medication (within 14 days of surgery) 5. decreased hepatic/renal function 6. patients who can not read the consent form or are not fluent in korean (illiterate, foreigner 7. pregnant, lactating women 8. palliative surgery
nonradiation-to-endoscopist endoscopic retrograde cholangiopancreatography in patients with complexity level i/ii

Conditions: Endoscopic Retrograde Cholangiopancreatography , Gallstone

Summary: radiation exposure may put endoscopists at risk when performing endoscopic retrograde cholangiopancreatography. although non-radiation endoscopic retrograde cholangiopancreatography was reported in pregnant women in previous reports, it remains unclear whether endoscopic retrograde cholangiopancreatography is also effective and safe when endoscopists were not expose to radiation. this study was to evaluate the effectiveness and safety of nonradiation-to-endoscopist endoscopic retrograde cholangiopancreatography in patients with complexity level i/ii.


Eligibility criteria:
inclusion criteria: * 18-90 years old * patients undergoing endoscopic retrograde cholangiopancreatography exclusion criteria: * 1 bismuth typy ⅲ and ⅳ * 2 common bile duct stone \> 15mm * 3 common bile duct stone and distal stenosis

Keywords: ercp nonradiation-to-endoscopist gallstones
evaluation of myocardial sympathetic denervation in parkinson's disease using [18f]fdopa

Conditions: Parkinson

Summary: the purpose of this study is to evaluate the added value of pet-ct with \[18f\]fdopa tracer for assessment of the myocardial sympathetic denervation in patients with or suspected with parkinson's disease. the investigators expect to see normal values of uptake ratio of \[18f\]fdopa , in patients with no synuclein underline pathology or previously known cardiovascular disease (no history of high blood pressure or take medications that influence the sympathetic system- exclusion criteria). low values of uptake ratio is presumed to be found in patients diagnosed with parkinson's disease or other synuclein pathology. the expected normal ratio of heart/liver uptake values will be determined from scans of patients refered to \[18f\]fdopa scan and were found to have normal \[18f\]fdopa scan of the basal ganglia and no cardiovascular diseases.

l-3,4-dihydroxy-6-\[18f\]fluoro-phenylalanine (\[18f\]fdopa) might be a useful tracer for assessing myocardial sympathetic denervation in parkinson's disease (pd) patients. compared to the routinely used i123 mibg scan, \[18f\]fdopa seems to have an advantage for the following reasons: 1. meta-iodobenzylguanidine (mibg) is a false analog of norepinephrine while \[18f\]fdopa is the radiolabelled form of dopa, a direct precursor of dopamine which is subsequently converted to norepinephrine 2. 123i mibg, un-like norepinephrine, dose not undergo intracellular metabolism (19) while \[18f\]fdopa undergo complex intracellular metabolism (17) 3. studies have shown that i123 mibg reuptake is almost exclusive by uptake mechanism 1. uptake-2 mechanism of 123i-mibg by the myocardium is not significant. reuptake of norepinephrine (ne) in the synaptic cleft and is mainly by uptake 1 system but also in small amount by uptake 2 systems. the investigators assumption is that this double mechanism of reuptake will increase the concentration of \[18f\]fdopa for better imaging

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 2. signed informed consent 3. patients referred for f-dopa scan of basal ganglia in the evaluation of parkinson's disease or other extra pyramidal motor disorders. 4. patients diagnosed with parkinson's disease. exclusion criteria: 1. age \< 18 2. previous diagnosed heart disease. 3. history of high blood pressure. 4. on medications that influence the sympathetic system.
improving ivf embryo quality grading using polarized light

Conditions: Infertility

Summary: selecting one or two ivf embryos with the highest potential to implant is extremely important for the success of the treatment- obtaining pregnancies and avoiding multi-fetal gestations. the currently used ivf embryo grading method is based solely on embryo morphology (cleavage rate and fragmentation) just before the transfer, which is not very well correlated with the implantation potential of each embryo. oocyte quality and adequacy are the most important factors determining the biological quality and implantation potential of the embryo. it impossible to grade oocytes using plain optical systems, other than maturity and gross anomalies. polscope systems allow to visualize intra ooplasmic structures and determine their retardance, as well as that of the zona pellucida. the investigators hypothesize that grading embryos using the oocyte's parameters as visualized by polscope is superior to conventional morphology and correlates better with their implantation potential. here the investigators will perform a prospective randomized controlled trial to examine this hypothesis.

each embryo will be graded in accordance to polscope based parameters; the presence of a spindle in the oocyte, its retardance, the distance between the spindle and the pb, and the thickness and retardance of the zp. in the experimental group the embryos for transfer will be selected based on these parameters, whereas in the control group they will be selected based on conventional morphologic criteria.

Eligibility criteria:
inclusion criteria: * age 18-38, (near) normal mf, normal uterus, \>4 aspirated oocytes, intent to transfer 1-2 embryos. exclusion criteria: * severe mf problems, uterine anomalies, pgd, rif.

Keywords: ivf, embryo selection, polarized light