Kornimate/medical-research-clean huggingface dataset:
aa on drug abusers by nursing students

Conditions: Drug Abuse

Summary: drug abuse is a serious public health issue. despite the serious consequences of drug abuse, there are around 2000 new cases reported by drug abusers each year. there is growing evidence of the use of auricular acupressure (aa), a traditional chinese medicine (tcm) treatment modality, in reducing withdrawal symptoms among drug abusers. this study aims to investigate the feasibility and effectiveness of training nursing students to deliver brief education on aa on drug abusers.

a 2-arm feasibility cluster rct will be conducted in the 80 drug abusers from 7 substance abuse clinics in hong kong hospital authority following the consort statement. the intervention group will receive aa intervention individually from trained nursing students. the control group will individually receive a 5-minute seminar delivered by a research assistant.

Eligibility criteria:
inclusion criteria: * aged 18 or above * have reported to abuse drugs within the past 30 days * can communicate in cantonese and read chinese exclusion criteria: * unstable mental conditions that are not suitable for the intervention * receiving acupuncture or acupressure treatment currently or in the previous 30 days

Keywords: auricular acupressure nursing students
comparison of mid-term results of total correction of tof between preservation of pv and trans-annular patch.

Conditions: Tetrology of Fallot

Summary: to compare of mid-term results of total correction of tetralogy of fallot between preservation of pulmonary valve and trans-annular patching , thus avoiding pv regurgitation during tof repair , this will determine the value of this procedure over trans-annular patching regarding to right ventricular performance.

surgical repair of congenital lesions associated with right ventricular outflow tract obstruction frequently requires the destruction of pulmonary valve (pv) competents including the pulmonary annulas. the resulatnt pulmonary insufficiency may lead to late functional deterioration of right ventricular performance. acute right ventricular dysfunction has been associated with poor pulmonary runoff, tricuspid valve regurgitaion and pulmonary hypertension. preservation of pv comptence may prevent both early and late right ventricular failure. total repair of tetralogy of fallot is a corrective surgical procedure that involves closure of the ventricular septal defect (vsd) and relief of right ventricular outflow tract (rvot) obstruction. the surgeon must decide whether the right ventricular outflow tract size will be sufficient to allow for the entire cardiac output to traverse it without causing extreme elevation in right ventricular pressure or will go for trans-annular patch. recently interest has shifted to preserving the integrity of the pulmonary valve annulus thus avoiding pulmonary valve regurgitation.

Eligibility criteria:
inclusion criteria: 1. patients undergoing elective total correction of tetralogy of fallot. 2. any age group. 3. normal pulmonay branches exclusion criteria: 1. patients associated with other congenital anomalies. 2. regarding pv morphology, patients with pulmonary atresia , absence of pv. 3. patients with anomalous coronary artery anatomy obstructs access to the rv 4. extra-cardiac illness that is expected to limit survival to less than 5 years.e.g active hepatitis or significant hepatic or renal disorders.
postoperative pain relieve for patients undergoing surgical treatment of femoral fracture

Conditions: Proximal Femur Fracture

Summary: the aim of the study is to investigate postoperative pain relief for patients undergoing surgical treatment of proximal femoral fracture using intrathecal administration of morphine.

in this study, the investigators will compare the efficiency of intrathecal morphine administration with the standard of care (parenteral application of analgesics) for pain relief in patients after proximal femoral fracture surgery. the secondary outcome measure will be to determine the frequency of adverse effects of intrathecally administered morphine. the study will be monocentric, randomized, and single-blinded. a total of 50 patients are expected to be enrolled.

Eligibility criteria:
inclusion criteria: * signed informed consent * 60 to 90 years of age * surgical treatment of proximal femur fracture * the american society of anesthesiologists (asa) classification i to iii * spinal anesthesia used for the operation exclusion criteria: * general anesthesia used for the operation * allergy to opioids * high risk of respiratory depression

Keywords: proximal femur fracture morphine administration pain relief intrathecal administration parenteral administration surgery
effects of eccentric training for patients with lateral epicondylalgia

Conditions: Tennis Elbow; Epicondylitis, Lateral Humeral

Summary: the purpose of this study is to evaluate eccentric training as an intervention for lateral epicondylalgia (tennis elbow) in a clinical setting.


Eligibility criteria:
inclusion criteria: * positive diagnostic criteria according to haker (1991): a history of pain around the lateral epicondyle for at least one month. * pain at palpation of the lateral epicondyle of humerus and positive results in two of the following three pain provocation tests: middle finger test, resisted extension of the wrist, and vigorimeter test. each of these tests is described in detail by haker (1991) exclusion criteria: * subjects with rheumatoid arthritis * fibromyalgia * previous surgery in the elbow region * neck dysfunction suggesting possible cervical rhizopathy * entrapment of n.radialis * patients with ongoing treatment, or previous treatment less than three months before enrolled to the study.

Keywords: elbow tendinitis sports medicine athletic injuries
a 2-year longitudinal study on the structural and optical effects of orthokeratology treatment on eye

Conditions: Myopic Progression

Summary: this is a two-year longitudinal study investigating the optical and structural effects of increased compression factor of orthokeratology lens on eyes and the corresponding effect on change in choroidal thickness and therefore myopic control.


Eligibility criteria:
inclusion criteria: * 6 to 10 years old * myopia: between 0.50 d and 4.00 d in both eyes * astigmatism: \<1.50 d; ≤ 1.25 d for with-the-rule astigmatism (axes 180 ± 30); ≤ 0.50 d for astigmatism of other axes in both eyes * anisometropia: ≤ 1.50 d * symmetrical corneal topography with corneal toricity \<2.00 d in both eyes * agree for randomization exclusion criteria: * contraindications for orthokeratology wear (e.g. limbus-to-limbus corneal cylinder and dislocated corneal apex) * any type of strabismus or amblyopia * myopic treatment (e.g. refractive surgery and progressive lens wear for myopic control) before and during the study period * rigid contact lenses (including orthokeratology lenses) experience * systemic condition which might affect refractive development (for example, down syndrome, marfan's syndrome) * ocular conditions which might affect the refractive error (for example, cataract, ptosis) * poor compliance for lens wear or follow-up

Keywords: myopia control orthokeratology
activity and participation in ambulatory cerebral palsy

Conditions: Cerebral Palsy

Summary: the investigators would like to understand how the physical activity levels and body size of a child with cerebral palsy (cp) in a clinical situations versus out in the community relates to what they want to do in day to day life (participation in life). the investigators believe that what a child really does out in day to day life will predict life participation to a greater degree than what they do in a structured clinical situation (i.e. therapy session with therapist). the investigators think that increased body size with normal growth is related to less physical activity and participation in day to day life for children with cerebral palsy (cp) who can walk. this project will use a novel accelerometer to measure walking activity during day to day life.

we want to know how the physical activity of children with walking problems or cerebral palsy (cp) relates to what they do in their day to day lives. we are looking for children who: * have walking problems that started before age 2 * have any type of cerebral palsy (cp) or primary problem that is a developmental movement disorder * may have hemiplegia, diplegia, walking quadriplegia, may have ataxia, spastic, mixed tone, athetoid, or dyskinetic * ages 2 years to less than 10 years * able to do some functional walking with or without help(walkers, gait trainers) * project requires a one time visit to seattle children's hospital of about 2 hours. * children and/or parents will complete surveys. * the child will be tested for their gross motor and walking skills like at a physical therapy session. * the child will be given an ankle monitor to wear for 7-10 days. * they will return the monitor by mail with a questionnaire about what they did the last week. * families will receive a print out of their child's walking activity

Eligibility criteria:
inclusion criteria: 1. age 2 to \<10 years (30 per four age groups/2 year increments) 2. gross motor function classification system (gmfcs) levels i-iii 3. diagnosis of cerebral palsy (cp) or developmental movement disorder that occurred prior to age two. exclusion criteria: 1. visual impairment limiting physical activity 2. lower extremity botox injections in the last 3 months 3. uncontrolled seizure disorder impacting mobility skills 4. orthopedic or neurosurgery in the last 6 months.

Keywords: cerebral palsy walking activity physical activity participation activity performance activity capacity
a post-marketing study on the safety of abatacept treatment in denmark using the danish database

Conditions: Rheumatoid Arthritis (RA); Psoriatic Arthritis (PsA)

Summary: the purpose of this study is to expand on the ongoing post-marketing monitoring of abatacept to include all participants with rheumatoid arthritis (ra) and psoriatic arthritis (psa) treated with abatacept captured in danish database for biologic therapies (danbio).


Eligibility criteria:
inclusion criteria: * diagnosis of rheumatoid arthritis (ra) or psoriatic arthritis (psa) * receiving treatment with abatacept * receiving treatment with non-targeted dmard * receiving treatment with targeted dmard exclusion criteria: -not applicable

Keywords: abatacept orencia malignancies long-term safety follow-up
observational study on therapy pathways of asthamics treated with ics/laba/lama therapy in a real-world setting

Conditions: Asthma

Summary: trimaximize is a non-interventional study aimed to collect prospective data from asthmatic patients under routine care, for whom their treating physician has decided to prescribe bdp/ff/g (beclomethasone/formoterol/glycopyrronium).


Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age; * patients with confirmed leading diagnosis of asthma with or without concomitant copd; * physician decision to start fixed triple therapy with ics/laba/lama (bdp/ff/g) ms or hs according to its current authorised indication and current reimbursement conditions within the italian national health system. the treatment decision must be made independently from participation in this study and may have started within the previous 4 weeks (maximum); * patients willing and able to sign an informed consent for use of their pseudonymised clinical data within the present non-interventional study. exclusion criteria: * participation in an interventional clinical trial within 30 days prior to enrolment into the present non-interventional study or planned enrolment in an interventional clinical trial during the observational period.

Keywords: asthma triple therapy beclomethasone formoterol glycopyrronium real-world single-inhaler quality of life control of asthma adherence
the analysis of efficacy factors for autologous platelet-rich plasma therapy in the treatment of elbow tendinopathy

Conditions: Elbow Tendinopathy

Summary: to identify key factors influencing the effectiveness of platelet-rich plasma (prp) therapy in treating elbow tendinopathy, a common degenerative condition.

this study focuses on evaluating the effectiveness and limitations of platelet-rich plasma (prp) therapy in treating elbow tendinopathy, a degenerative condition that includes lateral epicondylitis (tennis elbow) and medial epicondylitis (golfer's elbow). these conditions cause pain and reduced function in the elbow, with lateral epicondylitis being more common. prp, a regenerative treatment made from the patient's own blood, contains platelets concentrated 3-5 times higher than normal blood, releasing growth factors like tgf-β, pdgf, igf, and egf, which help tissue repair. prp therapy was first introduced for elbow tendinopathy in 2006 and has since been recognized for its potential in pain relief and healing, becoming a reimbursable treatment in korea since 2023. however, inconsistent clinical outcomes have been reported due to differences in prp preparation methods and platelet concentrations. research suggests that higher platelet counts and specific growth factors may enhance prp effectiveness. the international society on thrombosis \& haemostasis classifies prp based on platelet concentration, with some studies indicating that higher levels of tgf-β and il-1β improve outcomes. this study aims to identify the key components of prp that influence treatment success, focusing on platelet concentration and growth factor levels. the goal is to establish optimal prp preparation guidelines to ensure consistent and effective results for elbow tendinopathy, ultimately improving patient outcomes.

Eligibility criteria:
inclusion criteria: * adults aged 19 years or older * diagnosed with elbow tendinopathy * persistent pain despite receiving conservative treatment exclusion criteria: * individuals with systemic infection at the time of study participation * patients with rheumatic diseases or inflammatory disorders * individuals with unstable systemic conditions affecting the cardiovascular, gastrointestinal, respiratory, or endocrine systems * any other cases deemed inappropriate for study participation by the investigator

Keywords: platelet rich plasma protein array analysis growth factor patient-rated tennis elbow evaluation
tablet-based mobile health ultrasound for point-of-care breast cancer diagnosis in nigeria (mobile health: technology and outcomes in low and middle-income countries)

Conditions: Breast Cancer; Breast Cancer Female

Summary: the purpose of this study is to train nigerian radiologists to perform ultrasound-guided breast biopsies. researchers will use mhealth devices to create a sustainable and practical way of training radiologists in nigeria to perform and clinically implement us-guided breast biopsies into their practice.


Eligibility criteria:
inclusion criteria: * age 18 and older female. * breast ultrasound demonstrating a solid mass that is suspicious for cancer, which would typically undergo either a blind biopsy or surgical excision at the nigerian hospital where the patient is seeking diagnosis. exclusion criteria: * participants unwilling to sign consent. * participants under the age of 18.

Keywords: breast ultrasound breast cancer breast biopsy breast cancer diagnosis 21-325 memorial sloan kettering cancer center
comparison of desloratadine associated with prednisolone oral solution versus dexchlorpheniramine associated with betamethasone for cutaneous rash treatment

Conditions: Cutaneous Hypersensitivity

Summary: the purpose of this study is to evaluate the non-inferiority clinical efficacy of two different drug associations in the treatment of acute cutaneous rash in children between 2 and 12 years old.

* double-blind, non-inferiority, prospective, parallel group trial. * experiment duration: 05 days. * 03 visits (day 0, 48 hours and day 5). * efficacy will be evaluated for acute cutaneous rash based on symptoms score * adverse events evaluation.

Eligibility criteria:
inclusion criteria: * consent of the patient or legal guardian; * clinical diagnosis of acute cutaneous rash defined by the presence of erythematous papules on healthy skin, different sizes, itchy and fleeting * children aged between 2 and 11 years and 11 months (up to 30 kg); exclusion criteria: * participation in clinical trial in 30 days prior to study entry; * patients with history of hypersensitivity to desloratadine or prednisolone or with corticosteroids use contraindications ; * patients with any clinically significant disease other than cutaneous rash including hematopoietic, cardiovascular, renal, neurological, psychiatric or autoimmune disorders; * patients on treatment with monoamine oxidase inhibitors (maois); * patients diagnosed with other dermatoses
whole muscle exercise training (wholei+12) in pulmonary hypertension

Conditions: Exercise Therapy

Summary: the purpose of this rct is to study the effects of whole muscle training (inspiratory muscle training + aerobic training + muscle resistance training) on muscle power, vo2peak and gas-exchange variables obtained during cardiopulmonary exercise testing, qol, functional capacity (eg, 6-min walking distance), and maximal inspiratory pressure in patients with pulmonary artery hypertension.


Eligibility criteria:
inclusion criteria: * diagnosed pulmonary hypertension, class ii-iii nyha, no syncope in the last 3 months (stable clinical condition) or chronic thromboembolic pulmonary hypertension exclusion criteria: * not meeting the above
intra-atrial vs. extra-cardiac technique during fontan operation

Conditions: Congenital Disorders

Summary: our aim is a retrospective chart review seeking to determine any differences in the main clinical and outcome variables as well as general outcome data such as functional recovery, readmission rates, somatic growth and mortality. an n size of 150 to 200 for each of the 2 groups will give us excellent power to detect potential differences.

the fontan procedure is indicated as final-stage treatment for pediatric cardiac patients with single ventricle physiology. this procedure, whose aim is to provide for total cavopulmonary disconnect and perfusion of the pulmonary arteries via systemic veins, is performed via two differing techniques: intra-atrial, so-called lateral tunnel technique, employing ptfe graft material and internal atrial baffle, versus the extracardiac technique, using larger ptfe tubing and externally constructed baffle. there is persistent debate regarding the optimal technique to use, centered around the following main issues: 1) need for use of cardiopulmonary bypass and attendant consequences, 2) rates of thrombosis and embolism, 3) incidence of postoperative protein-losing enteropathy (ple), 4) incidence of arrhythmias, and 5) baffle patency rates. a handful of small- to medium-sized studies has addressed the above issues, but, importantly, has not used patient data from the same institution. here at choa, there are an estimated 200+ lateral tunnel, and have been up to 125 to 150 extracardiac fontan procedures, performed in the last 15 years (1.1.1980-3.31.2005). data from these cases would be potentially very helpful in answering all of these questions.

Eligibility criteria:
inclusion criteria: * children's healthcare of atlanta patients * lateral tunnel procedure during 1.1.1990-3.31.2005 * extracardiac fontan procedures during 1.1.1990 - 3.31.2005 exclusion criteria: * those who do not meet inclusion criteria

Keywords: fontan procedure single ventricle physiology intra-atrial extracardiac technique
hernia prevention in stomas

Conditions: Incisional Hernia; Parastomal Hernia

Summary: knowing that the risk of stoma associated herniation (parastomal or incisional) is 30-50% and the associated morbidity significant, standard placement of a prophylactic mesh upon stoma creation might prevent parastomal (or incisional herniation, after closure) and improve the quality of life of a large group of patients. this study is meant to be a pilot study to see whether the mesh related risks of infection and adhesion morbidity are acceptable if the mesh is placed intraperitoneally.

the idea of a prophylactic mesh has been tested before in a swedish randomized controlled trial (rct) with the mesh placed upon end colostomy formation. results suggest this procedure is the panacea against stoma associated herniations. the investigators still have unanswered questions however, about the size and ideal position of the mesh, possible complications (infection, adhesions) and the benefit in terms of quality of life.

Eligibility criteria:
inclusion criteria: * adult patients with a life expectancy of at least one year * temporary stoma formation * signed informed consent * elective surgery * clean-contaminated abdomen exclusion criteria: * american society of anaesthesiologists (asa) score iv or above * incapacitated adult or no signed informed consent * emergency procedure * contaminated or infected abdomen * residual intraperitoneal mesh * already injured part of the abdominal wall where the stoma will be sited * contraindication to laparoscopy * longterm use of corticosteroids and other immunosuppressive agents * current antibiotic therapy * one of the following conditions: immune deficiency, chemotherapy, ascites, peritoneal dialysis, pregnancy

Keywords: stoma
cardioprotective effects of electroacupuncture pretreatment against coronary stenting

Conditions: Myocardial Injury

Summary: myocyte necrosis as a result of elective percutaneous coronary intervention (pci) occurs in approximately one third of cases and is associated with subsequent cardiovascular events. this study assesses the ability of electroacupuncture (ea) pretreatment to attenuate cardiac troponin i (ctni) release after elective pci.

elective percutaneous coronary intervention (pci) is associated with troponin release in approximately one third of cases.troponin release is a sensitive and specific marker of myocyte necrosis and infarction resulting from a form of ischemia/reperfusion injury, downstream embolization of atheromatous material, and coronary side-branch occlusion. a number of studies have demonstrated that procedure-related troponin release is associated with subsequent cardiovascular events. transient sublethal episodes of ischemia before a prolonged ischemia/reperfusion injury, known as ischemic preconditioning (ipc), have been shown to reduce the extent of myocardial infarction (mi).electroacupuncture (ea) stimulus, as a pretreatment method, limits mi size in animal models. however, there are limited outcome to demonstrate protection from ea pretreatment during pci. the present study investigated the ability of ea pretreatment to attenuate cardiac troponin i (ctni) release after elective pci in a single-center, randomized controlled trial.

Eligibility criteria:
inclusion criteria: * all patients \> 18 of age who are undergoing elective pci and are able to give informed consent are eligible for study. exclusion criteria: * emergency pci, * elevation of ctni before pci taken at the preadmission clinic, * women of child-bearing age, * nicorandil or glibenclamide use (preconditioning-mimetic and preconditioning blocking medication, respectively), and * severe comorbidity (estimated life expectancy \< 6 months).

Keywords: ischemia myocardial infarction prognosis pretreatment electroacupuncture stents troponin percutaneous coronary intervention