Kornimate/medical-research-clean huggingface dataset:
clinical and radiographic evaluation of propolis as a hemostatic agent for pulpotomy of mature permanent molars with irreversible pulpitis using two different dressing materials

Conditions: Irreversible Pulpitis; Pulpitis; Pulpitis - Irreversible

Summary: the goal of this clinical trial is to assess the effectiveness of propolis as a hemostatic agent in pulpotomy for adult permanent molars, compared to sodium hypochlorite (naocl). it also examines how bioceramic putty performs against mineral trioxide aggregate (mta) in vital pulp therapy for cases of irreversible pulpitis. participants will be divided into four groups (15 patients each): * propolis + bioceramic putty * propolis + mta * sodium hypochlorite + bioceramic putty * sodium hypochlorite + mta the investigator will record the bleeding time and postoperative pain will be recorded. the researcher will assess the clinical and radiographic outcomes for success at 1, 3, and 6 months.


Eligibility criteria:
inclusion criteria: * participants of both genders falling within the age range of 20 to 45 years. * presence of vital mature permanent molars diagnosed as mild or severe irreversible pulpitis per wolter's classification. * confirmation of vital bleeding pulp tissue in all canals following complete pulpotomy. exclusion criteria: * non-vital teeth. * teeth with immature roots. * uncontrolled pulpal bleeding persisting beyond 10 minutes post-application of sodium hypochlorite as a hemostatic agent. * insufficient bleeding post-pulp exposure, indicative of pulp degeneration.

Keywords: pulpotomy vital pulp therapy adult pulpotomy irreversible pulpitis hemostasis hemostatic agent propolis mta bioceramic full pulpotomy mineral trioxide aggregate moderate pulpitis severe pulpitis mature permanent molars
naked eye 3d vision training for the prevention and control of myopia in adolescents and children

Conditions: Adolescents and Children; Axial Elongation; Naked Eye 3D Vision Training; Visual Function

Summary: the study used children aged 6-18 as subjects to evaluate the efficacy and safety of naked eye 3d vision training for the prevention and control of myopia in adolescents. a total of 250 subjects were recruited from zhongshan ophthalmology center of sun yat-sen university, shenzhen people's hospital and foshan women's and children's hospital, with 1:1 as intervention group and control group. the study assumes that daily naked eye 3d vision training can effectively control the speed of axial elongation and the progression of myopia. the main indicators were the use of optical biometrics to detect the subjects' initial axial length and the axial length after 1 month, 3 months and 6 months of intervention. secondary indicators were refraction, uncorrected visual acuity, best corrected visual acuity, choroidal thickness, and binocular vision.


Eligibility criteria:
inclusion criteria: 1. age 6\~18 years old (including 6 years old and 18 years old), gender is not limited; 2. written informed consent signed by the child and legal guardian has been obtained; 3. patients who have visited the research center in the past month, diagnosed as myopia according to the "guidelines for the prevention and treatment of myopia" issued by the general office of the national health commission (guoweiban medical letter \[2018\] no. 393), and the spherical equivalent power is -0.75 to -6.00 diopter (d) (including -0.75 and -6.00 d); 4. astigmatism≤4.00 d, anisometropia≤4.00 d; 5. monocular international standard logarithmic visual acuity after spectacle correction ≥20/25; 6. the subject's guardian can understand the purpose of this study, and the subject can cooperate with the treatment and related eye examinations. exclusion criteria: 1. any eye of the subject suffers from overt strabismus, or any other pathological changes in the eyeball or acute inflammatory disease of the eye; 2. subjects who may suffer from eye diseases that affect vision or refractive errors (such as cataract and other lens damage diseases, glaucoma, macular degeneration, keratopathy, uveitis, retinal detachment, severe vitreous opacity, etc.); 3. systemic diseases: those with a history of immune system diseases, central nervous system diseases, down syndrome, asthma, severe heart and lung function, severe liver and kidney dysfunction; 4. binocular hyperopia cannot be corrected to logarithmic visual acuity of 20/25; 5. the subject has or is undergoing myopia control treatment within the past 1 month, such as atropine eye drops, orthokeratology lenses, progressive lenses, bifocal lenses, etc.; 6. photophobia or unable to open eyes normally due to keratitis, trichiasis, trauma, etc. in any eye of the subjects; 7. subjects participated in other clinical studies 4 weeks before enrollment; 8. for safety reasons or the interests of patients, the investigator believes that patients should not participate in other situations in this study.
open-label extension study of astoria

Conditions: Dyskinesias

Summary: this current open-label extension (ole) study (jm-010cs-ol) will explore the safety and tolerability of long-term administration of jm-010 of patients who completed 12-week treatment of phase 2 (jm-010cs03) study.


Eligibility criteria:
inclusion criteria: 1. is able to read, understand, and provide written, dated informed consent. 2. subjects will be deemed likely to comply with study protocol and communicate with study personnel about adverse events (aes) and other clinically important information. 3. completed study visits per protocol in a previous jm-010cs03 study. 4. ambulatory or ambulatory-aided (e.g. walker or cane) ability while on, such that the subject can complete study assessments; 5. knowledgeable and reliable caregiver/study partner, if appropriate, to accompany the subject to perform study visits and assist in completion of study instruments, as needed and allowed; 6. the subject himself/herself wishes to continue taking jm-010, and the investigator deems continued administration to be necessary or appropriate. exclusion criteria: 1. discontinued study drug in a previous jm-010 dyskinesia efficacy study due to intolerable or unacceptable aes considered to be related to jm-010. 2. has other psychiatric (not including hallucinations due to side effects of dopamine therapy), neurological or behavioral disorders that in the opinion of the investigator may interfere with the conduct or interpretation of the study, including dementia, or subject who is considered violent. 3. has a significant risk for suicidal behavior in the opinion of the investigator during the course of their participation in the study or * at screening visit: the subject scores "yes" on items 4 or 5 in the suicidal ideation section of the c-ssrs with reference to a 6-month period prior to screening visit; or * at screening visit: the subject has had 1 or more suicidal attempts with reference to a 2 year period prior to screening visit; or * at baseline visit: the subject scores "yes" on items 4 or 5 in the suicidal ideation section of the c ssrs with reference to screening visit 4. has current seizure disorders (other than febrile seizures in childhood) requiring treatment with anti convulsants.
a pilot study of robot-assisted therapy for post-stroke forearm and wrist rehabilitation training

Conditions: Stroke

Summary: a pilot study to assess the effectiveness of cr2-haptic and determine the feasibility of including robotic therapy into the daily rehabilitation program.

the objective of this study is to clinically assess the effectiveness of cr2-haptic and determine the feasibility of including robotic therapy into the daily rehabilitation program, and investigate the acceptance from patients and therapists. total of 7 patients will be recruited in this study, all the patients will receive 1.5 hours of standard therapy together with 0.5 hour of robot therapy every day. the robot therapy will be a 30 mins long session for 3 to 5 days per week over a period of six weeks. the study will include forearm pronation-supination and wrist flexion-extension training.

Eligibility criteria:
inclusion criteria: * sub-acute and chronic stroke patients * able to rest comfortable in training set-up * mini-mental status examination (mmse) score (\>21) * motor assessment scale (balance sitting \>3) * modified ashworth scale (wrist \< 2) exclusion criteria: * contractures in affected upper extremity which inhibit movements being tested

Keywords: stroke robot-assisted therapy rehabilitation
reassessment strategy in the diagnosis of coronary heart disease in elderly

Conditions: Myocardial Ischemia

Summary: despite the effectiveness of beta-blockers and antiplatelet agents for secondary prevention of coronary heart disease, this treatments are underused in the elderly because of diagnosis uncertainty and underuse of efficient treatment. in a first time, diagnosis reassessment with invasive technique if necessary. in a second time, treatment reassessment.

not desired

Eligibility criteria:
inclusion criteria: * patients 75 of age or older hospitalized in a geriatric service and suspect of coronary heart disease exclusion criteria: * acute myocardial infarction

Keywords: veterans
efficacy of segmental examination twice of the proximal colon on adenoma detection

Conditions: Colonic Polyps

Summary: segmental examination twice of the proximal colon might be helpful to increase adenoma detection rate (adr).

colonoscopy is the gold standard screening test for colorectal cancer (crc). removal of adenomas can reduce the incidence and mortality of crc. however, there is evidence that some patients may develop interval cancers-cancers developed within 3-5 years following colonoscopy and polypectomy. the overall rate of interval cancer was 1.1-2.7 per 1000 person-years. several studies have suggested that patients who develop interval cancers are more likely to have proximal compared than distal cancers. one hypothesis is that adenomas may be more likely to be missed in the proximal colon compared with the distal colon. serrated polyps and some adenomas in the proximal colon may be difficult to detect if they are flat, covered with mucus, or behind folds. a second hypothesis is that neoplastic lesions of the proximal colon may biologically differ from distal lesions and progress to malignancy with a short dwell time. several tandem back to back colonoscopy studies have demonstrated that up to 27% adenomas in the proximal colon are missed during routine screening colonoscopy. hover, examining the colon twice as that in the back to back studies is difficult to be performed in clinical practice. thus, we developed a novel colonoscopy technique, segmental examination twice of the proximal colon, that is simple and easy to be performed. the current study aims to examine the efficacy of segmental examination twice of the proximal colon on adenoma detection rate (adr) during routine screening and surveillance colonoscopy.

Eligibility criteria:
inclusion criteria: * asia-pacific colorectal screening score ≥2, such as patients ≥ 50 years, patients with a family history of colorectal cancer in a first-degree relative or male patients with current or past smoking. exclusion criteria: * patients with prior resection of the proximal colon, advanced colonic cancer, inflammatory bowel disease, or polyposis syndrome. * the cecum could not be intubated. * inadequate bowel preparation (boston bowel preparation scale score \<2 in any segment of the colon). * biopsies were not available. * unable to provide informed consent.

Keywords: adenoma detection rate colonoscopy withdrawal time
study of the association between digital eye syndrome with binocular vision and the ocular surface in higher education students in the area of health technologies

Conditions: Digital Eye Strain

Summary: the goal of this observational study is to determinate the association between des and changes in binocular vision and ocular surface. in higher education students in the area of health technologies. the main questions it aims to determine the prevalence of digital eye syndrome (des); the association between des and changes in binocular vision and ocular surface; whether the time of use and the type of electronic devices influences the degree and type of symptoms of des; and to determine whether there is an association between the type of ametropia and the symptoms of des. participants will have to answer 3 questionnaires (the computer vision syndrome questionnaire; the convergence insufficiency symptoms survey, and the dry eye questionnaire (deq-5)) and then they will perform an orthoptic assessment and an assessment of the ocular surface with the tear film break up time (but) test.


Eligibility criteria:
inclusion criteria: * students of the first, second and third year of the degrees offered by lisbon school of health technology, instituto politécnico de lisboa; * age between 18 to 39 years; * accept and sign the consent. exclusion criteria: * working students; * students with known binocular vision disorders; * previous eye surgeries.

Keywords: accommodation convergence tear film
identification of the impact of acute pancreatitis on quality of life

Conditions: Acute Pancreatitis; Quality of Life

Summary: in abdomen, the pancreas as a gland is involved in the digestive and endocrine system by secreting digestive enzymes and insulin. acute pancreatitis (ap) is a common inflammatory condition of the pancreas with symptoms of sudden abdominal pain and high temperature which may develop to severe complications in some patients. the incidence of ap was roughly 33.74 cases per 100, 000 person-years around the world but varies in different regions which america has the highest incidence of 58.20 cases per 100 000 person-years. there are very few studies published on ap in china, while japanese national survey in 2011 estimated an incidence rate of 49.4 per 100,000 population and a study in taiwan showed an annual average incidence of 36.9 per 100,000 persons with a slight change over ten years. in most cases, patient with ap will start to recover within a week, but the patient quality of life (qol) is still a big concern for disease management. it quantitatively measures the physical, mental and social wellbeing of individuals or their life satisfaction by questionnaires or surveys. although very few studies have demonstrated the effect of ap on patient qol, there is accumulating evidence to show its importance. some studies reported no differences in qol between ap patients and age-matched healthy people, whereas others showed qol was significantly impaired due to ap. a large population-based follow-up study is needed to evaluate the impact of acute pancreatitis on quality of life. in addition, as the population investigated in most research was european based, the qol evaluation of patients after ap among the chinese population is also essential.


Eligibility criteria:
inclusion criteria: * acute pancreatitis. * must be able to response an online survey. exclusion criteria: • n/a

Keywords: acute pancreatitis quality of life
effectiveness of two stress management programs in adaptation disorder with anxiety (ada)

Conditions: Adjustment Disorders; Psychological Stress

Summary: the aim of this study was to assess the effects of a 5-week standardized cognitive behavioral treatment of stress management conducted via e-learning or face-to-face on patients responding to the diagnosis of adjustment disorder with anxiety (ada) according to the dsm- 5 (diagnostic and statistical manual of mental disorders fifth edition) criteria .

the program includes 5 weekly sessions that the patient follows. it is based on standard cbt (cognitive behavioural therapy) principles and includes five modules (information about stress and stress reaction and assessment; deep respiration and relaxation techniques; cognitive re-structuration; mindfulness and acceptation; behavioral skills as solving problem, time management, healthy behaviors, problem solving and emotion regulation ...). * in internet-based group patient benefits from a minimal contact with a medical member of staff before and after every session. it is supplied to the patient, from the first session an usb key containing videos, audio files, help-self book portfolio in the form of e-guide, log books with the program of the exercises to be realized between two session of the 5 sessions program. the patient is encouraged to practice a twenty-minutes daily of exercises five or six days per week. * in face-to-face group, patient receive the same program with a therapist in 5 weekly sessions without digital supports.

Eligibility criteria:
inclusion criteria: * adjustment disorder with anxiety (ada) according dsm-5 (the diagnosis was made according to the mini questionnaire). * subscore anxiety \> 10, subscore depression \< 10 at hospital anxiety depression scale (hads) * computer at home exclusion criteria: * subscore anxiety \ 10 at hospital anxiety depression scale (hads) * no others current psychiatric diagnostic according dsm- 5 * no suicidal ideation

Keywords: stress management cognitive behavioural therapy (cbt) self-help e-health adjustment disorder with anxiety
a non-interventional, observational post-marketing registry of patients treated with revlimid (lenalidomide) in taiwan

Conditions: Multiple Myeloma

Summary: the revlimid registry will provide safety data from a large cohort of taiwanese patients treated with revlimid. in addition, the registry will provide efficacy data and outcomes in a real-world setting (versus a clinical trial).

the revlimid registry is a prospective, multi-center, observational study. the registry will register 100 patients being prescribed revlimid in taiwan during and patients will be followed for two years after the enrollment of the last patient. safety and efficacy data will be recorded in the registry monthly or bi-monthly. in accordance with the risk minimization program for revlimid (revassure) a patient categorized as a woman of childbearing potential will be prescribed revlimid on a monthly basis, whereas women of non-childbearing potential and men will be allowed up to two months supply per prescription. after entry of baseline data, the prescribing physician should prescribe and monitor revlimid therapy according to the guidance and recommended schedules given in the approved taiwan package insert (pi)

Eligibility criteria:
inclusion criteria: * adult patients 18 years of age or older * patients that are being prescribed revlimid in combination with dexamethasone for the treatment of multiple myeloma and that have received at least one prior therapy * patient must be willing and able to provide informed consent * patients will be informed about the registry and will have to sign a specific registry informed consent form * be able to ask questions prior to signing the subject information and consent form * be clearly informed that their involvement/participation in the registry is voluntary * understand that their medical care will not be altered in any way by their participation in the registry exclusion criteria: - a patient who is unwilling or unable to provide informed consent will not be included.

Keywords: multiple myeloma
predictive assays in cervix cancer

Conditions: Cervical Cancer

Summary: the experiments outlined in this proposal will compare a number of currently available techniques for assessing hypoxia and interstitial fluid pressures in patients with cervix cancer. the aim of these experiments is to establish the relationship of the clinically relevant outcome measures of tumour control and survival following radiation therapy with these biological characteristics of carcinoma of the cervix relevant to tumour hypoxia. these characteristics will be assessed in patients undergoing treatment using techniques which have reached an appropriate level of development for clinical evaluation and aim to determine the best technique for determining these parameters of the tumour microenvironment. a number of novel strategies directed at the microenvironment are undergoing or soon will be undergoing clinical evaluation and selection of appropriate patients for these trials is of great importance.


Eligibility criteria:
inclusion criteria: 1. histologic diagnosis of cervix cancer 2. a decision to treat using radiation therapy according to the existing treatment policies of the pmh gynecology group 3. clinical stage ib-iv with grossly evident cervical disease 4. no distant metastases 5. no cytotoxic anti-cancer therapy for cervical carcinoma prior to study entry 6. signed informed consent exclusion criteria: -

Keywords: cervical cancer assay hypoxia
a phase 1b/2 study of medi4736 with tremelimumab, medi4736 or tremelimumab monotherapy in gastric or gej adenocarcinoma

Conditions: Gastric or Gastroesophageal Junction Adenocarcinoma

Summary: this is a randomized, multicenter, open-label, dose-exploration and dose-expansion study to evaluate the safety, tolerability, antitumor activity, pk, pharmacodynamics, and immunogenicity of medi4736 in combination with tremelimumab, medi4736 monotherapy or tremelimumab monotherapy in participants with metastatic or recurrent gastric or gastroesophageal junction adenocarcinoma.


Eligibility criteria:
inclusion criteria: 1. male and female participants 2. 18 years and older 3. histological or cytological confirmation of metastatic or recurrent gastric or gastroesophageal junction adenocarcinoma 4. participants must have received and have progressed, or are refractory to standard regimens 5. participants must have at least one lesion amenable to biospy exclusion criteria: 1. any concurrent chemotherapy, immunotherapy, biologic, or hormonal therapy for cancer treatment 2. previous immunotherapy 3. concurrent or prior use of immunosuppressive medication with 14 days 4. active or prior documented autoimmune or inflammatory disease within 3 years with some exceptions

Keywords: gastric adenocarcinoma gastroesophageal junction adenocarcinoma immunotherapy antibodies, monoclonal tremelimumab medi4736
airway segmented stent modified with 3d printing for malignant stricture involving carina and distal bronchi

Conditions: Stricture; Trachea; Malignant Neoplasm

Summary: in this study, we used the covered metallic segmented airway stent to treat malignant strictures involving carina and bronchi distal to carina and aimed to determine the feasibility, efficacy and safety of this technique.


Eligibility criteria:
inclusion criteria: * patients with malignant stricture involving carina and bronchi distal to carina based on the diagnosis by bronchoscopy or ct. exclusion criteria: * severe infection * coagulation disorders

Keywords: 3d printed airway stent carina distal bronchi
benefit 15 long-term follow-up study of the benefit and benefit follow-up studies

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to obtain long-term clinical data from patients approximately 15 years after their first clinical event, who participated in the former benefit 304747 study and were treated at least once within that study. this study will collect clinical information on the disease course, on disability, relapses, cognitive function over time, quality of life, depression, fatigue, resource use, and employment status. in addition, brain mri is performed.


Eligibility criteria:
inclusion criteria: * all subjects who were treated at least once in benefit study 304747 are eligible for inclusion in the benefit 15 study exclusion criteria: * subjects who, according to the investigator's judgment, have medical, psychiatric, or other conditions that compromise the subject's ability to understand the purpose of the study * suspected clinical instability or unpredictability of the clinical course during the study(e.g., due to previous surgery or acute stroke)

Keywords: clinically isolated syndrome suggestive of multiple sclerosis or multiple sclerosis