Kornimate/medical-research-clean huggingface dataset:
pain management after shoulder prosthesis: a clinical trial of nerve block and local infiltration

Conditions: Pain, Postoperative

Summary: the purpose of this study is to determine the efficacy of local infiltration analgesia as compared to 48-hour interscalene block in treating pain after shoulder arthroplasty. the investigators hypothesize a reduced pain score and use of supplemental analgesic medication during the first three postoperative days using local infiltration analgesia.


Eligibility criteria:
inclusion criteria: * elective primary shoulder arthroplasty exclusion criteria: * reverse or delta prosthesis * recent fracture near the shoulder * allergic to amid-type local analgesics * operation not under general anaesthesia * incompetent, pregnant, below 18 or above 90 years old * severe chronic neurogenic pain or sensory disturbances in the shoulder

Keywords: shoulder arthroplasty local infiltration analgesia
prevalence of variants of nasal cavity and nasal septum in nepalese

Conditions: Nasal Septum; Deviation, Congenital

Summary: a retrospective study was conducted on 343 patients. ct pns and head of the patients were evaluated for variants of nasal septum and nasal cavity.

a retrospective study was conducted on 343 patients aged 13 years and above. two investigators, each with 3 to 4 years of experience in the field of radiology, evaluated computed tomography scans of the paranasal sinuses and the head of these patients. the nasal septum was evaluated for degree and types of variants. various variants of nasal cavities and nasal septum were also evaluated.

Eligibility criteria:
inclusion criteria: 1)patients undergoing ncct pns and head for chronic rhinosinusitis, headache and vertigo exclusion criteria: 1. patient less than 13 years age 2. patients with recent trauma 3. patient with large mass/ extensive polyposis

Keywords: nasal septum nasal cavity turbinate
a study of ridaforolimus in non-small cell lung cancer (nsclc) patients with kirsten rat sarcoma viral oncogene homolog (kras) mutations (mk-8669-021 am1)

Conditions: Non-Small Cell Lung Cancer

Summary: this is a randomized discontinuation study of ridaforolimus in patients with advanced nsclc who have failed at least 1 but no more than 3 prior treatment regimens and who have kras mutant lung cancer. following 8 weeks of open-label ridaforolimus lead-in there will be an assessment of disease status. patients assessed by the investigator to have stable disease after 8 weeks will be randomized to double-blind treatment with ridaforolimus or placebo. patients assessed to have partial or complete response will continue on open-label ridaforolimus. patients assessed to have disease progression will be discontinued from study.

allocation and arms additional information: all patients will receive an 8-week open-label lead-in treatment of ridaforolimus. after this 8 week period patients will be re-assessed for disease status. patients who are stable after 8 weeks are randomized in a double-blind fashion to continue treatment with ridaforolimus or to a placebo until disease progression. (those patients who have stable disease but are randomized to placebo may cross-over to open-label ridaforolimus at the time of disease progression.) those patients with tumor shrinkage during the open-label lead-in treatment will continue on open-label ridaforolimus, while those patients who have disease progression at 8-weeks are taken off-study.

Eligibility criteria:
inclusion criteria: * patient has histologically confirmed stage iiib/iv non-small cell lung cancer * patient has a documented mutation of the kras gene * patient has evidence of disease progression following 1 but no more than 3 prior chemotherapy regimens * a minimum of 4 weeks has passed since the most recent anti-cancer treatment * women of childbearing potential must have a negative pregnancy test prior to start of therapy and must use an approved contraceptive method for the duration of the study * patient has adequate organ function * patient has performance status of \<=2 on eastern cooperative oncology group (ecog) performance scale * patient is \>=18 years of age exclusion criteria: * patient has received more than 2 prior chemotherapy regimens for the treatment lung cancer * patient is known to have active brain metastases * patient is currently participating or has participated in an investigational drug study within 30 days * patient is known to be human immunodeficiency virus (hiv) positive or has a known history of hepatitis b or c * patient has an active infection requiring prescribed intervention * patient has newly diagnosed or un-controlled type 1 or 2 diabetes
mechanism for exercise to delay cardiac aging

Conditions: Activity, Motor; Health Behavior

Summary: the goal of this clinicaltrial is to assess and compare isokinetic performance, surface electromyography, laboratory parameters, and cardiorespiratory function both before and after engaging in vigorous intermittent lifestyle physical activity(vilpa) within a healthy population. the main question it aims to answer is: \[1\] does vilpa yield effective outcomes? throughout the course of the trial, participants will engage in a simulated regimen of vigorous intermittent lifestyle physical activity for a duration of 8 weeks. the efficacy of the exercise protocol will be quantified and evaluated through the utilization of a wearable device.


Eligibility criteria:
inclusion criteria: 1. healthy adults 2. no exercise habits (more than 3 months) exclusion criteria: 1. exercising ≥ 3 times per week; 2. the presence of chronic diseases, such as hypertension, hyperglycemic states, etc; 3. have conducted an exercise program in the past three months.

Keywords: vigorous intermittent lifestyle physical activity wearable device isokinetic performance
analysis of heart rate variability after a physical exercise session

Conditions: Hypertension

Summary: systemic arterial hypertension (sah) is a multifactorial clinical condition, characterized by sustained elevation of blood pressure levels, contributing to 50% of deaths from cardiovascular disease. the autonomic nervous system (ans) plays a fundamental role in the regulation of blood pressure (bp) and is closely associated with heart rate (hr). hr changes are called heart rate variability (hrv). in individuals with sah, hrv indices are reduced compared to normotensive individuals, showing changes in autonomic modulation, thus increasing the risk for cardiovascular events. the objective of this study will be to analyze the heart rate variability in individuals with controlled sah after a session of aerobic (ea) or resistance (re) physical exercise.

controlled hypertensive individuals aged between 30 and 59 years will be selected, for convenience, who use the services of the instituto de cardiologia do rio grande do sul. volunteers will be randomly assigned to an ea session (40 minutes on cycle ergometer, 60% of heart rate reserve) or re (2 exercises for lower limbs and 2 for upper limbs with 4 sets of 12 repetitions at 60% 1-rm) or control group without exercise. hrv data will be collected by ecg (wincardio usb - version 11.1.0.0, micromed biotecnologia ltda, brasília - df - brazil) during 10 minutes before the exercise session, 10 minutes after the exercise session, 1h and 2h post-session . it is expected to estimate results that may demonstrate clarifications about the impact of a physical exercise session on hrv in controlled hypertensive individuals.

Eligibility criteria:
inclusion criteria: * controlled systemic alterial hypertension exclusion criteria: * diabetes mellitus; * heart failure; * coronary artery disease; * chronic renal failure; * body mass index (bmi) ≥ 35 kg/m2; * smokers; * individuals with injuries to the upper and lower limbs that make the exercise protocol impossible; * not using antihypertensive medication and using beta-blocker and/or alpha-blocker medication.
the effect of peri-percutaneous coronary intervention oxygenation on myocardial protection & cardiovascular fitness

Conditions: Myocardial Ischemia; Cardiovascular Morbidity

Summary: elective percutaneous coronary intervention (pci) is often associated with myocardial necrosis evidenced by peri-procedural troponin release. this is a surrogate for subsequent cardiovascular events. there is no study on the effect of peri-pci oxygenation in in myocardial protection and cardiopulmonary fitness outcome. patients with higher baseline cardiopulmonary fitness will have lower mortality. this study is to assess the utility of oxygen to reduce ischaemia in patients with significant stable coronary artery disease scheduled for elective pci. the secondary objective is to evaluate further effect of peri- pci oxygenation on cardiovascular fitness and autonomic response.

objective: this study is to assess the utility of oxygen to reduce ischaemia in patients with significant stable coronary artery disease scheduled for elective pci. the secondary objective is to evaluate further effect of peri- pci oxygenation on cardiovascular fitness and autonomic response. study design: randomized double blinded prospective pilot study sample size: 30 patients scheduled for elective for pci randomized to 2 groups, oxygen group ( 15l/min) and air group method: patient whom fulfil inclusion criteria were recruited and randomized to 2 groups via computer allocation system. the assigned inhaled gas will be delivered via high-flow mask at 15l/min for a minimum of 30 minutes immediately prior to and continued throughout the pci procedure. patients were blinded throughout the procedure but the practising cardiologist and staff nurses were not blinded. routine care continued post pci. blood sampling for troponin i was taken at 6 hours and 24 hours following stent implantation. patients were discharged one day after the procedure as per current routine practice. patients were given routine follow up with the cardiac rehabilitation clinic in 4 weeks time post discharge. est was arranged 6 weeks post procedure primary outcome measure: troponin i at 6 and 24 hours secondary outcome measure: mets, heart rate recovery, chronotropic index

Eligibility criteria:
inclusion criteria: * patients aged \>18 years * haemodynamically important coronary artery disease (\>70% luminal stenosis angiographically in ≥1 major epicardial coronary artery exclusion criteria: * significant chronic airways disease with type-2 respiratory failure precluding safe use of oxygen * coronary stenoses where evidence of plaque instability is evident e.g. rest pain, visual evidence of thrombus, elevation of troponin t at baseline

Keywords: myocardial protection oxygen exercise test
air barrier system for the reduction of airborne colony-forming units during total shoulder arthroplasty

Conditions: Osteo Arthritis Shoulders

Summary: the objective of this study is to determine whether the air barrier system device reduces airborne colony-forming units (e.g., bacteria) present at a surgery site during total shoulder arthroplasty surgeries.

the air barrier system (abs) is a device that uses localized clean air flow to shield a surgery site from ambient airborne contamination. this study examines the hypothesis that the abs can reduce the presence of airborne cfu and particles at the surgery site during total arthroplasty surgery.

Eligibility criteria:
inclusion criteria: * candidate for total shoulder arthroplasty exclusion criteria: * prior history of infection * revision surgery * screens positive for mrsa

Keywords: total shoulder replacement operating room air surgical site infection airborne cfu
procalcitonin as a tool to shorten antibiotic therapy in the icu

Conditions: Sepsis

Summary: recently, biomarkers like procalcitonin have been studied in order to help physicians to decrease the duration of the antibiotic therapy. the investigators objective was to assess whether the decrease in procalcitonin levels could be used to reduce the antibiotic therapy in critically ill patients with a proven infection without risking a worse outcome.


Eligibility criteria:
inclusion criteria: * all patients admitted in the intensive care unit with sepsis, severe sepsis and septic shock with a microbiologically confirmed infection (blood, urine, tracheal aspirate or bronchoalveolar fluid culture) exclusion criteria: * onset of the antibiotic therapy more than 48 hours before the date when the cultures were performed * patients less than 18 years old * known pregnancy * infections requiring prolonged antibotic therapy such as endocarditis, hepatic or brain abscess, deep abscess, mediastinitis and osteomyelitis * severe infection caused by virus, parasites, fungi or chronic prostatitis * negative cultures in patients with suspected sepsis, severe sepsis or septic shock

Keywords: procalcitonin duration of the antibiotic therapy sepsis
rhinosinusites chroniques

Conditions: Sinusitis; Chronic Disease; Refractory

Summary: to analyse and describe sinus microbiota, during hard to treat (or refractory) rhinosinusitis, using culturomic and metagenomic methods (i.e. to culture on many different medium of culture to grow hard to cultivate bacteria + to sequence and analyse all dna contained in samples). samples are middle meatus swabs or pus aspiration, done during usually patient following.


Eligibility criteria:
inclusion criteria: * \>18 year old * chronic refractory rhinosinusitis * to require middle meatus swab or other sinus sample * absence of opposition exclusion criteria: * \<18 year old * pregnant women * breastfeeding * under trusteeship * under guardianship
pentraxin-3 in hysterectomy patients

Conditions: Laparoscopic Hysterectomy; Abdominal Hysterectomy

Summary: comparison of the tissue trauma markers following total laparoscopic hysterectomy vs total abdominal hysterectomy

acute trauma and major surgeries activate a series of cascades to evoke systemic inflammatory response. the magnitude of the resulting inflammatory response is proportional to the severity of the tissue trauma. abdominal or laparoscopic technique is widely used for the purpose of hysterectomy surgery. it is crucial for many aspects to compare these two techniques of hysterectomy in terms of the surgery-induced trauma. in this study, the severity of the inflammatory response resulting from the tissue trauma due to the techniques of tlh+bso and tah+bso applied in our department were compared based on the ptx-3 molecule.

Eligibility criteria:
inclusion criteria: ·tlh+bso patients and tah+bso patients exclusion criteria: * history of a chronic disease (coronary artery disease, diabetes mellitus, hypertension, coronary liver failures, chronic kidney disease, chronic respiratory diseases, connective tissue disorders) which may affect levels of ptx-3 and other inflammatory markers. * prior surgery due to malignancy. * history of an intra-abdominal surgery, except for cesarean section. * history of any disease which may lead to intra-abdominal adhesions (endometriosis, past pelvic infection).

Keywords: pentraxin-3 tissue trauma hysterectomy neutrophil to lymphocyte ratio
mannitol brain relaxation effect

Conditions: Supratentorial Neoplasms

Summary: mannitol is widely used in patients with elevated intracranial pressure. in neurosurgical field, especially in large size or with brain edema, it is necessary to decrease brain volume to facilitate surgical approach. in general, 0.25 -1.5g of mannitol per kilogram has been known to decrease icp effectively. but there are some debates in regard to appropriate dose of mannitol.

previous meta-analysis reported that mannitol has dose-response relationship with intracranial pressure. another study of sorani showed dose-response relationship between mannitol and intracranial pressure (icp) in traumatic brain injury patients. in this study, authors would investigate that mannitol increments can provide more brain relaxation in patients undergoing craniotomy for supratentorial brain tumor removal.

Eligibility criteria:
inclusion criteria: * patients who underwent craniotomy for supratentorial brain tumor under general anesthesia exclusion criteria: * patient who does not agree to the study * patients with or american society of anesthesiologists (asa) physical status class iv or more * patients with glasgow coma scale (gcs) under 13 points * patients who have hyponatremia or hypernatremia (na\ 150meq/l) * patients who have congestive heart failure or moderately decreased renal function (gfr \<60ml/min/1.73m2) * patients with extraventricular drainage such as external ventricular drain (evd) or ventriculoperitoneal (vp) shunt * patients who already under mannitolization
the feasibility of pertussis immunization in a canadian emergency department

Conditions: Pertussis

Summary: randomized controlled trial of 2 strategies to provide adults with the tdap vaccine to patients presenting to the emergency department. rates of vaccination as well as effects on department efficiency will be measured.

this study is a prospective randomized, controlled trial of two strategies to provide patients with the pertussis vaccine. eligible adult patients with be offered pertussis vaccination in the emergency department vs. a referral to public health for pertussis vaccination. the effect of both strategies on triage time as well as measure of emergency department efficiency including length of stay, time to physician and left without being seen rates will be compared. at a four-month follow up, rates of pertussis vaccination will be measured.

Eligibility criteria:
inclusion criteria: * adults age 18 and above * have not received tdap vaccine as an adult (age 18 and above) or have not received tdap vaccine within 10 years, or unsure of vaccination status exclusion criteria: * acute significant illness (canadian triage and acuity scale = 1) * deemed "in too much distress" by triage nurse * acute febrile illness * allergy to vaccine or vaccine components * pts presenting for wound care (are normally given the vaccine as part of wound care) * pregnancy \< 26 weeks

Keywords: pertussis vaccination emergency department
loss of cervical lordosis in fibromyalgia syndrome

Conditions: Fibromyalgia, Cervical Lordosis

Summary: purpose: the causes of chronic and widespread pain in fibromyalgia (fms) have not been eluciated yet. previous reports determined that posture control changed, muscle strength decreased, body posture misaligned (maladaptive posture), and functional capacity decreased in fms patients. the aim of this study was to investigate the relationship between loss of cervical lordosis, pain, quality of life (qol) and neck disability in patients with fms. methods: a total of 107 fms (88 females and 20 males; range of age:18-65) were included to the study. patients were divided into two groups according to the angle of cervical lordosis measured by the cobb method, group 1 with a cobb angle of ≤10°, and group 2 with an angle greater than \>10°. visual analog scale (vas), qol (36-item short form survey (sf-36)), and neck disability index (ndi) were used to assess pain, overall quality of life, functional disability respectively.


Eligibility criteria:
inclusion criteria: age range between 18 and 65 -patients diagnosed with fibromyalgia according to the american college of rheumatology 1990 criteria exclusion criteria: patients diagnosed with known systemic (e.g., inflammatory rheumatic diseases, diabetes mellitus and systemic arterial hypertension), metabolic or endocrine diseasesas well as tumoral, neurologic or infectious diseases, * patients with a history of trauma and surgery affecting the neck area, * patients who received trigger point injection therapy for neck pain within the last 6 months, * patients with cervical disc herniation or myelopathy, spondylolisthesis, spondylolysis, cervicothoracic kyphoscoliosis, * patients who had been receiving therapy for any psychiatric diagnosis for the last 3 months and antidepressant drug use, * patients with history of neuropathic diseases, * patients with a condition affecting neck muscles, such as dystonia, * inflammatory muscle disease and myopathy * pregnant patients were not included to the study

Keywords: fibromyalgia, cervical lordosis
role of vitamin c to augment iron chelation with dfp or dfx

Conditions: Vitamin c; Thalassemia Major; Iron Chelation

Summary: role of vit c to augment iron chelation with dfp or dfx in thalassemic patients.

assess safety and efficacy of vit c to augment iron chelation with dfp or dfx in thalassemic patients.

Eligibility criteria:
inclusion criteria: * • subjects with overload secondary to thalassemia major exclusion criteria: * • with hiv positive or have active hcv. * a history of serious immunologic hypersensitivity to any medication such as anaphylaxis or angioedema. * participation in a previous investigational drug study within the 30 days preceding screening. * a woman of childbearing potential must have a negative serum pregnancy test at screening. she must use a medically acceptable form of birth control during the study and for a month afterwards who are pregnant or breast-feeding. * an inability to adhere to the designated procedures and restrictions of this protocol.

Keywords: vitamin c thalassemia major iron chelation
brain iron toxicity and neurodegeneration - a 7t mri study

Conditions: Prodromal Alzheimer's Disease; Mild Cognitive Impairment

Summary: a longitudinal observational neuroimaging study of individuals with early onset alzheimer's disease during the prodromal phase, and matched control group - ultrahigh field mri study at 7t

this study aims to determine whether high resolution mri at 7t and quantitative susceptibility mapping (qsm) can demonstrate a specific pattern of iron overload in strategically important areas of brain as a sensitive marker of pathological alzheimer's disease i.e. patients with subjective or mild cognitive impairment associated with amyloid or tau pathological state in the cerebrospinal fluid.

Eligibility criteria:
inclusion criteria: * ability to provide informed consent * patients with pathological diagnosis of alzheimer's disease according to the national institute on aging and alzheimer's association, nia-aa, criteria (alzheimer's group) or cognitively normal individuals within 1.5 standard deviation of normal in all tests (control group) exclusion criteria: * lack of mental capacity to consent to study involvement * not speaking english before age 5 years * learning disability * schizophrenia * substance misuse * implanted devices not certified as compatible with ultra-high field mri (e.g. cardiac pacemaker) * pregnancy

Keywords: ultrahigh field mri 7t mri qsm