Kornimate/medical-research-clean huggingface dataset:
culturally adapted cognitive behavioral therapy for prevention of self harm

Conditions: Attempted Suicide; Depression

Summary: aim: to adapt and develop a culturally appropriate psychological intervention and test its feasibility, and acceptability for the patients presenting to general hospital following self-harm in karachi pakistan. primary hypothesis: patients who receive cognitive behavioral therapy will show significant decrease in suicidal ideation as compared to patients with treatment as usual. design: randomized control trial setting: medical departments of general hospitals in karachi. participants: a total of 200 self harm patients will be randomized to psychological intervention and treatment as usual arm. intervention: culturally adapted cognitive behavioral therapy (cbt) outcome measure: beck suicidal ideation scale

culturally adapted manualised cognitive behavioral therapy (cbt) will be a brief problem focused therapy comprising of 6 sessions within three months after a self-harm episode. the adapted therapy/training will be delivered by therapists/trained counselors at the hospital. sessions will be offered weekly in the first two weeks and than fortnightly and will last 50 minutes. during each session the therapists will assess the risk of suicide and will liaise with the research supervisor and patient's treating clinician. the areas covered by the manual which has been adapted include an evaluation of the self-harm attempt, crisis skills, problem solving, and basic cognitive techniques to manage emotions and negative thinking and relapse prevention strategies. the treatment will be structured around patient's current problems with the relevant sections of the manual helping the patient to deal with specific problems leading to the self-harm act. between the sessions the manual can be used for homework tasks by the patient.

Eligibility criteria:
inclusion criteria: * an episode of self harm within 48 hours before being admitted at the department; * age of 16 to 64 years; * resident in the trial site catchments area, * ability to complete a baseline assessment; * ability to provide at least 2 verifiable contacts to improve tracking for subsequent assessments; and ability to understand and provide informed consent. exclusion criteria: * • a medical disorder that would prevent participation in an outpatient clinical trial. * temporary resident unlikely to be available for follow up. * diagnosis of alcohol and other drug dependence, schizophrenia or bipolar disorders.

Keywords: cbt, self harm, depression, cultural adaptation, pakistan
massage therapy for breast cancer treatment-related swelling of the arms

Conditions: Lymphedema

Summary: the purpose of this study is to examine the short-term and long-term efficacy of massage therapy alone compared to massage therapy plus compression bandaging in the treatment of breast cancer treatment-related swelling of the arms and legs.

massage therapy (in the form of manual lymph drainage \[mld\]) and compression bandaging (cb) are integral components of combined physical therapy (cpt), the recommended treatment for peripheral lymphedema (le). according to the world health organization, le afflicts hundreds of millions worldwide and probably millions in the united states. effects of various forms of massage on lymph circulation have been postulated for more than a century, but the efficacy of mld alone without cb has not been demonstrated. new data suggest that mld alone reduces established le volume as effectively as cb in combination with cpt and minimizes le development. patients will be randomly assigned to either treatment with mld alone or a combination of mld and cb. patients will be treated in 10 one-hour sessions over 2 weeks. they will also undergo lymphangioscintigraphy (a nuclear medicine test) to depict the function of their lymphatic system. patients will continue self treatment at home and will be followed for 6 months.

Eligibility criteria:
inclusion criteria: * lymphedema (5% to 20% increase in volume) after breast cancer treatment exclusion criteria: * physically unable to perform massage or bandaging during home program

Keywords: manual lymph drainage combined physiotherapy
pharmacy education during covid-19 outbreak

Conditions: Event, Life Change

Summary: coronavirus disease 2019 (covid-19) outbreak is considered one of the most important public health crisis all over the world. general recommendations and rules around the world have been legislated to avoid or delay transmission of covid-19. education process and learning plan are changed to focus on online learning instead of traditional educational model. pharmacy is one of the important practical medical science which affected by covid-19 outbreak.

detailed description: the survey will enroll as many individuals of the egyptian pharmacy students as possible in the survey portion of the study - the number of participates have no limitations, at least 100 participants. the survey will be enrolled in online google form, face to face interview(this will be reduced to encourage social isolation) \& semi-structured telephone interviews if possible. the research procedures: an online survey link will include questions regarding the effect of covid 19 pandemic on the educational process in egypt,and how the online learning process are affecting pharmacy students it will measure the impact on the psychological health of the students as well as their level of understanding of information.and their overall satisfaction from the e learning method of education used during the covid 19 pandemic face to face and semi-structured interviews if possible: for those egyptian citizens who state that they would like to participate in an interview, a random sample will be contacted. inclusion criteria: pharmacy students exclusion criteria: non pharmacy students

Eligibility criteria:
inclusion criteria: * pharmacy students exclusion criteria: * non pharmacy students
early prostate cancer: predicting treatment response

Conditions: Prostate Cancer

Summary: this study will replicate/validate the risk prediction model developed for the comparative effectiveness analysis of surgery and radiation (ceasar) study in a more diverse patient population to assess generalizability of the model as well as evaluate the relative contribution of the decipher prostate cancer test and prostatenext test from ambry genetics, to the risk prediction model for estimating treatment outcomes, and thereby improve personalization of treatment options.

the study will contribute a replicable model for improving risk prediction from patient characteristics, clinical severity indicators, and genomic tests to aid in personalizing treatment. the proposed registry would also allow future comparisons of the gene expression used in other competing commercial test. the addition of the suggested genomic classifier and its associations with other patient and clinical characteristics will enhance the ability of future studies, analogous to ceasar, to accurately predict the risk of tumor aggressiveness in prostate cancer.

Eligibility criteria:
inclusion criteria: * 18 - 90 years of age * prostate-specific antigen (psa) values \<50ng/ml * clinical stage of t1 or t2 * no evidence of metastasis or nodal involvement exclusion criteria: * age 91 or greater * clinically locally advanced or metastatic disease * psa equal to or greater than 50ng/ml * diagnosis of malignancy (excluding squamous or basal cell carcinoma of the skin) within 3 years of diagnosis of prostate cancer

Keywords: genomics racial disparities patient reported outcomes
robot-assisted esophagectomy versus conventional thoracoscopic esophagectomy

Conditions: Esophageal Cancer; Esophageal Carcinoma

Summary: this is the first randomized controlled study to compare the robot-assisted esophagectomy (rae) to minimally invasive conventional thoracoscopic esophagectomy (cte). the aim of this trial is to evaluate the safety, risks of the robot-assisted esophagectomy, and to compare the short-term operative outcomes and long-term oncological outcomes between the two surgical treatments.

objective: this study aims to compare the oncological outcomes between robot-assisted esophagectomy and minimally invasive conventional thoracoscopic esophagectomy. study design: randomized controlled parallel-group superiority trial study population: patients (age \>= 18 and \<= 75 years) with histologically proven surgically resectable (ct1b-3, n0-2, m0) squamous cell carcinoma of the intrathoracic esophagus with european clinical oncology group performance status 0, 1 or 2. intervention: 360 patients will be randomly allocated to either a) robot-assisted esophagectomy (n=180) or b) conventional thoracoscopic esophagectomy (n=180). patients will receive the following interventions: group a. robot assisted esophagectomy, with gastric conduit formation. group b. conventional thoracoscopic esophagectomy, with gastric conduit formation. main study parameters/endpoints: primary outcome is 5-year overall survival rate. secondary outcomes are 5-year disease free survival, 3-year overall survival rate, 3-year disease free survival, (in hospital) mortality within 30 and 60 days, r0 resections, operation related events, postoperative recovery, lymph nodes status, quality of life. follow-up: 60 months after discharge of the last randomized patient.

Eligibility criteria:
inclusion criteria: * histologically proven squamous cell carcinoma of the intrathoracic esophagus. * surgical resectable (t1b-3, n0-2, m0) * age ≥ 18 and ≤ 75 years * european clinical oncology group performance status 0, 1 or 2 * written informed consent exclusion criteria: * carcinoma of the cervical esophagus * histologically proven adenocarcinoma or undifferentiated carcinoma. * prior thoracic surgery at the right hemithorax or thorax trauma. * infectious disease with systemic therapy indicated.

Keywords: robot assisted esophagectomy minimally invasive esophagectomy esophageal cancer
holep vs bprp in the management of a large volume (> 80 gm) symptomatic bph

Conditions: BPH With Urinary Obstruction; Male

Summary: to compare bipolar resection versus holmium laser enucleation for management of symptomatic large bph (\> 80 gm)

to compare safety and efficacy of bipolar resection (bprp) versus holmium laser enucleation (holep) for management of symptomatic large bph (\> 80 gm)

Eligibility criteria:
inclusion criteria: * patients suffering from luts secondary to infravesical obstruction from bph with failed medical treatment * international prostate symptom score (ipss) \> 13 * a peak urinary flow rate (qmax) \< 15 ml/sec * a prostate size ≥ 80 gm exclusion criteria: * presence of a urethral stricture * neurological disorder * bladder cancer * prostate cancer * previous history of bladder neck surgery or turp

Keywords: bph enucleation large prostate luts ipss quality of life
use of bipolar diathermy vs clips in laparoscopic appendectomy

Conditions: Laparoscopic Appendectomy; Bipolar Diathermy

Summary: acute appendicitis is the most frequent acute pathological abdominal illness needing immediate surgery. the laparoscopic appendectomy (la) has become more popular and is advised as the first course of treatment, particularly for female, obese, and elderly patients.la can also give surgeons a greater field view and identification of other abdominal organs that can have different pathologies that could mimic the symptoms of acute appendicitis.the most crucial step in preventing major complications such postoperative bleeding, peritonitis, sepsis is sealing the mesoappendix. due to this circumstance, surgeons are looking for alternative treatments for la. the best technique for sealing mesoappendix should be affordable, practical, safe, and easy to apply technically. extracorporeal sliding knots, intracorporeal ligations, endo-loops, nonabsorbable polymer clips (hem-o-lock clips), hand-made loops, and ligasure usage, and bipolar cautery division are some of the techniques utilized at la to seal mesoappendix. according to studies, each of these techniques is secure and practicable.5 in this study, there is a comparative study between using bipolar diathermy as a source of sealing and other mechanical closure techniques for mesoappendix to assess effect of energy source sealing of mesoappendix by using bipolar diathermy in comparison to mechanical closure by clips as regard outcome and complications.


Eligibility criteria:
inclusion criteria: * all patients admitted to auh with uncomplicated acute appendicitis or chronic appendicitis * age group (18-70) exclusion criteria: * patients with complex appendicitis (appendicular mass, abscess, etc). * patients who had the following conditions: cirrhosis with ascites, abdominal distention, and coagulation disorders, cardiac patients; shock upon arrival, a large ventral hernia, and inflammatory bowel disease
creatine and gaa for brain oxygenation

Conditions: Oxygen Deficiency

Summary: the main aim of this randomized controlled trial is to evaluate cerebral blood oxygenation after 7-day administration of a creatine-guanidinoacetic acid (gaa) mixture in healthy adults before, during, and after a series of cognitive tests.


Eligibility criteria:
inclusion criteria: * age 18-30 years * absence of metabolic disorders or other health complications * provision of signed informed consent exclusion criteria: * history of dietary supplement use within the preceding 4 weeks * lack of consent to randomization * concurrent participation in other studies

Keywords: creatine guanidinoacetic acid oxygen saturation brain
mri of myocardial infarction

Conditions: Myocardial Infarction; Myocardial Ischemia; Myocardial Injury; Myocardial Fibrosis; Myocardial Reperfusion Injury; Myocardial Edema; Myocardial Necrosis; Heart Failure; Ischemic Heart Disease; Ischemic Cardiomyopathy; Hemorrhage

Summary: heart failure (hf) is an enormous health burden affecting approximately 5.1 million people in the us and is the cause of 250,000 deaths each year. approximately 50% of hf is caused by myocardial ischemia and requires immediate restoration of coronary blood flow to the affected myocardium. however, the success of reperfusion is partly limited by intramyocardial hemorrhage, which is the deposition of intravascular material into the myocardium. hemorrhagic reperfusion injury has high prevalence and patients have a much greater risk of adverse left ventricular remodeling, risk of fatal arrhythmia, impaired systolic function and are hospitalized at a greater rate. recent magnetic resonance imaging techniques have improved assessment of reperfusion injury, however, the association between mri contrasts and reperfusion injury is highly unclear, and lacks specificity to imh. improved imaging of imh and accurate knowledge about its spatial and temporal evolution may be essential for delivery of optimal medical therapy in patients and critical to identify patients most at risk for adverse ventricular remodeling. the overall goal is to investigate the magnetic properties of hemorrhage and develop mri techniques with improved specificity to hemorrhage. new mri techniques permit noninvasive assessment of the magnetic susceptibility of tissues and can target tissue iron. therefore, the investigators hypothesize that mri imaging of myocardial magnetic susceptibility can map hemorrhagic myocardium. the investigators will perform a longitudinal observational study in patients after reperfusion injury to validate these methods, compare the methods with conventional mr contrasts and develop mr methods for imaging humans.


Eligibility criteria:
inclusion criteria: * between the ages of 18 and 80 * patients must be able to read and understand english * participants must sign the informed consent form * elevated and delayed peak creatine kinase-mb and troponin i (ctni) and troponin t (ctnt) in blood serum, * st elevation detected on ecg exclusion criteria: * contraindications to cardiac mri, including claustrophobia * advanced renal disease (estimated glomerular filtration rate 30 ml/min) or hypersensitivity to gadolinium * presence of a cardiac pacemaker or implanted cardiac cardioverter defibrillator * pregnancy * personal or family history of hypertrophic cardiomyopathy * inability to provide informed consent * history of seizure disorder
the effects of a very low carbohydrate diet intervention on weight control in overweight/obese patients in china

Conditions: Overweight

Summary: the study was designed to investigate the effects of a very low carbohydrate diet (vlcd) intervention on weight control in overweight/obese patients in china.all the subjects were randomly assigned to experiment group and control group. the experimental group was given individual instructions on how to follow the vlcd (very low carbohydrate diet). the control group was given an energy-restricted diet.the energy-restricted diet (er diet) was designed in the traditional chinese style with an initial target for a total energy intake of 1200 kcal/d (5021 kj/d).

121 obese or overweight patients were enrolled in the study and 23 patients were dropped out (43 male, 55 female, aged≥18 years, bmi≥24 kg/m2) from the outpatient clinic of endocrinology and metabolism department of southern medical university affiliated zhujiang hospital. all the subjects were randomly assigned to experiment group and control group. the experimental group was given individual instructions on how to follow the vlcd (very low carbohydrate diet). energy intake was restricted to less than 800kcal/day (3349kj/d) (carbohydrate intake \< 20g/d). all daily meals were replaced as follows: a cup of soybean milk (200 ml) and a boiled egg at breakfast; a diet nutrition bar (106 kcal: 2.8 g carbohydrate, 11.2 g protein and 5.6 g fat; nutriease health technology co., ltd., hangzhou, china), nonstarchy vegetables (\<200 kcal), and 50 g protein from meat (i.e., beef, lean pork, skinned chicken, fish) at lunch and dinner. supplementation of multivitamins and minerals was provided per day. the energy-restricted diet (er diet) was designed in the traditional chinese style with an initial target for a total energy intake of 1200 kcal/d (5021 kj/d). subjects were also encouraged to drink at least 1.8 litres of water per day, and asked to maintain their habitual level of physical activity. compliance with the diet and physical activity level was checked at weekly visits.

Eligibility criteria:
inclusion criteria: * overweight or obese healthy volunteers (43 male, 55 female, aged≥18years, bmi≥24 kg/m2) exclusion criteria: * pregnant or plan for pregnant * lactation or postmenopausal women * use of any prescription medication in previous 2 months * had any weight loss diet or pill during the past 6 months * consuming\>20 g/day of alcohol * tobacco use within 6 month * cardiovascular or endocrine disease history * hypertension history or current elevated blood pressure (systolic blood pressure (sbp): ≥150 mmhg; diastolic blood pressure (dbp)≥90 mmhg; current treatment for hypertension) * diabetes mellitus * acute or chronic infections * hepatopathy, kidney disease, gastrointestinal disease or any other acute or chronic diseases requiring treatment.

Keywords: very low carbohydrate diet overweight/obese
exercise therapy with risk factor management and life style coaching after vascular intervention for patients with peripheral arterial disease

Conditions: Peripheral Arterial Disease, Rutherford 4 and 5 With Possibility to Improve Vascularization

Summary: patients with peripheral arterial disease with symptoms of critical ischemia or reduced tissue loss have a very high mortality and morbidity rate. so far, treatment strategies focused on the preservation of life and limb by an open surgical or endovascular revascularization, together with cardiovascular risk management and pain relief. important modifiable factors related to mortality and morbidity are not covered in the current national and international guidelines. this study investigates the effects on mobility, mortality and quality of life with supplementation of the standard treatment of critical limb ischemia with supervised exercise therapy. also a reduction of cardiovascular risk by intensive risk factor management and lifestyle coaching will be taken in to account. the supervised exercise therapy will take place under the supervision of a trained physiotherapist.


Eligibility criteria:
inclusion criteria: * patients with peripheral arterial disease rutherford stage 4 and 5, where it is possible to improve the vascularization of the affected leg with the help of an endovascular and / or open surgical vascular intervention. * patients with both legs are affected, but the most severe leg does not exceed stage 5. exclusion criteria: * severe cardiopulmonary comorbidity (nyha 4) and previous amputations of lower leg or thigh. * patients with limited amputation of the toes can participate. * insufficient understanding of the dutch language. * no physiotherapy insurance.
a study to investigate the safety and efficacy of lt-02 in patients with mesalamine refractory ulcerative colitis (uc)

Conditions: Ulcerative Colitis

Summary: the purpose of this study is to determine whether phosphatidylcholine (lt-02) add on treatment is effective and safe for the induction of remission in ulcerative colitis patients refractory to standard treatment with mesalamine

a randomized, double-blind, placebo-controlled study to assess the efficacy and safety of lt-02 (delayed release phosphatidylcholine granules; administered orally via 1.6 g bid for up to 12 weeks) in subjects with active ulcerative colitis who are refractory to a standard dose of oral mesalamine therapy. refractory to mesalamine is defined as active disease despite receiving at least ≥ 2.4g mesalamine (or equivalent dose) for at least 8 weeks with or without rectal 5-asa.

Eligibility criteria:
key inclusion criteria: 1. established diagnosis of ulcerative colitis (uc), based on clinical history, exclusion of infectious causes, and characteristic endoscopic and histologic findings. 2. active uc with disease confirmed by endoscopy findings and confirmed by central reader. 3. a modified mayo score 4-10, and with a centrally read endoscopy score activity of ≥ 2 points. 4. mesalamine (5-asa) refractory. exclusion criteria: 1. diagnosis of crohn's disease, indeterminate colitis, ischemic colitis, radiation colitis, microscopic colitis (i.e., collagenous colitis and lymphocytic colitis), diverticular disease associated colitis, 2. toxic megacolon or fulminant colitis, 3. prior colon resection, 4. evidence of infectious colitis (e.g., pathogenic bacteria or clostridium difficile infection) at screening, 5. known celiac disease 6. other inflammatory or bleeding disorders of the colon and intestine, or diseases what may cause diarrhea or gastrointestinal bleeding 7. history or presence of ischemic heart disease, myocardial infarction, peripheral arterial disease, ischemic stroke, or transient ischemic attack, 8. subjects with known hypersensitivity to soy, 9. treatment with methotrexate, azathioprine, 6-mercaptopurine tnf-alpha-antagonists, vedolizumab or certolizumab pegol, tacrolimus, or anti-integrin therapy within last 8 weeks prior to screening, 10. treatment with any (topical or systemic) corticosteroid formulation for the treatment of ibd within last 7 days prior to endoscopy, 11. treatment with other investigational drug within last 8 weeks prior to screening,

Keywords: colitis colitis, ulcerative ulcer colonic diseases digestive system diseases gastroenteritis gastrointestinal diseases inflammatory bowel diseases intestinal diseases pathologic processes mesalamine