Kornimate/medical-research-clean huggingface dataset:
hepatic metabolism of galactose and the galactose analog fdgal in patients with liver disease and healthy subjects

Conditions: Liver Cirrhosis

Summary: the elimination of the carbohydrate galactose is used in daily clinical work with liver patients as a quantitative measure of metabolic liver function, as the liver test "the galactose elimination capacity", gec. we are working to develop a pet/ct scanning procedure for providing 3d images of the hepatic galactose elimination and measurement of regional values. this may be used for example for planning resection or stereotactic radiotherapy of a patient with malignant tumor in the liver. will the patient be able to tolerate removal of the necessary part of the liver? we will include 10 patients with liver cirrhosis and 6 healthy human subjects. direct measurements of the hepatic galactose elimination (successive constant iv infusions of galactose in increasing doses with measurements of blood concentrations of galactose in blood from an artery and a liver vein, and measurements of liver blood flow by indocyanine green, ficks principle) are compared with pet/ct measurements after iv injection of a 18f-labelled galactose analog, fdgal. based on previous studies in pigs, we perform detailed calculations of the hepatic galactose elimination kinetics by the two methods, including estimation of a factor ("lumped constant") for recalculating pet/ct data to data for natural galactose. besides possible practical clinical importance, the project elucidates basic problems concerning liver metabolism using pet.


Eligibility criteria:
inclusion criteria: * liver cirrhosis exclusion criteria: * hepatic encephalopathy * pregnancy

Keywords: galactose pet/ct liver physiology liver pathophysiology
intramuscular ketamine for suicidal ideation

Conditions: Suicidal Ideation

Summary: the objective of the present research protocol, a cross-over, subject-blinded, clinical trial, is to correlate changes in brain activity with reduction in suicidal ideation in response to a single intramuscular dose of ketamine. while ketamine is increasingly used as a rapid, antidepressant agent, there is accumulating evidence of additional anti-suicidal properties that may be distinct from its effects on depression. this pilot study will be used to determine (1) whether specific electroencephalogram (eeg) findings are correlated with response of si to intramuscular (im) ketamine, and (2) the effectiveness of im ketamine in the treatment of acute si.


Eligibility criteria:
inclusion criteria: * current clinically significant suicidal ideation, defined as a score of \> or = 4 on the madrs item 10 and a positive answer on items 3,4 or 5 of the c-ssrs. * inpatient status at the time of study initiation. * 18 to 70 years of age * capacity to consent exclusion criteria: * diagnosis of a primary psychotic disorder (e.g., schizoaffective disorder) * diagnosis of pervasive developmental disorder * diagnosis of a major neurocognitive disorder * a positive urine pregnancy test * currently breastfeeding * drug or alcohol abuse or dependence within the preceding 3 months; a rather narrow time period was chosen, however, in order to allow participation by individuals with a history of substance abuse or dependence problems that could be secondary to their si, and to more closely approximate patients seen in real-world settings. given the increasingly widespread use of marijuana, and in an effort to recruit a naturalistic study population, concurrent marijuana use is not an exclusion criterion, as long as they are not actively intoxicated. * current positive utox for amphetamine, benzodiazepines, cocaine, opiates (if not prescribed) * medical issues or laboratory abnormalities requiring acute intervention * patients for whom an increase in blood pressure or intracranial pressure would pose a serious risk (e.g., aneurysmal vascular disease, arteriovenous malformation, history of intracerebral hemorrhage, unstable angina) * any lifetime history of ketamine or phencyclidine abuse * a known hypersensitivity to or history of a serious adverse effect from to ketamine

Keywords: suicide eeg ketamine
sunitinib intake conditions in the treatment of patients with renal cell carcinoma

Conditions: Renal Cell Carcinoma

Summary: this non-interventional study includes patients with advanced renal cell carcinoma who are treated with sunitinib alone or combined with other systemic therapies. the aim of the trial is to increase knowledge about usage, dosage, efficacy and safety under conditions of routine use of sunitinib.

because state food and drug administration (sfda) exempted manufacturers from conducting clinical trials of sunitinib in china, overall efficacy and safety data of sunitinib in chinese patients with renal cell carcinoma were deficiency. the investigators carried out this research project will be sufficient evidence, and help clinicians in china to make decision in real daily practice.

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed, unresectable advanced renal cell carcinoma; * sunitinib as first-line treatment alone or combined with other therapies. exclusion criteria: * history of grade 3/4 severe allergic reaction to sunitinib or its metabolites

Keywords: sunitinib kidney diseases urogenital neoplasms kidney cancer
comparison of two intermittent urinary catheters

Conditions: Urinary Retention

Summary: this is an unblinded, multi-center, randomized, controlled, cross-over study assessing wheel-chair bound, male user preference and catheter characteristics of two intermittent urinary catheters. subjects enrolled in the study will be randomized to order of catheter use. individual participation will consist of approximately 1 week of product use. the null hypothesis to be tested is there no difference between catheters.

1. is male and at least 18 years of age. 2. is self-catheterizing at least 3 times a day. 3. has been performing catheterizations for at least 2 months. 4. is wheelchair bound. 5. is able to use a size 12 or 14 french straight catheter. 6. is willing and able to follow the study protocol and investigator's instructions. 7. is in the opinion of the investigator, qualified to participate.

Eligibility criteria:
inclusion criteria: * is male and at least 18 years of age * is self-catheterizing at least 3 times a day * has been performing catheterizations for at least 2 months * wheelchair bound * is able to use a size 12 or 14 french straight catheter * is willing and able to follow the study protocol and investigator's instructions * is, in the opinion of the investigator, qualified to participate exclusion criteria: * has cognitive impairments that preclude completion of study protocol * cannot communicate as determined by the investigator * has an existing medical condition that, in the opinion of the investigator, would interfere with the subject's ability to participate or in the interpretation of the results * has a symptomatic urinary tract infection determined by interview * has a retracted penis * has participated in a study during the previous 30 days involving catheterization * has been diagnosed with an enlarged prostate * has urethral strictures, false passages, or urethral obstruction

Keywords: intermittent catheter preference
gebt lot-to-lot and biological variability

Conditions: Gastroparesis

Summary: the purpose of this study is to collect information regarding lot-to-lot variability in 13c-spirulina test meal lets and within-subject biological variability.

in this study participants will participate in one or two arms of the study. in one arm the participants will be administered gebt tests that contain different 13c-spirulina/egg mix drug lots. in the second arm, the participants will be administered gebt tests from the same 13c-spirulina/egg mix drug lot. all gebt kit lots will be administered according to the fda-approved labeling.

Eligibility criteria:
inclusion criteria: * males and females, 18-85 years old at time of signing the informed consent form * ability to eat test meal and provide breath samples exclusion criteria: * history or physical exam suggestive of systemic disease such as diabetes mellitus or pathophysiologic disorders such as renal failure, chronic heart disease, chronic respiratory disease, liver disease, or malabsorption. * history of abdominal surgery except appendectomy * use of any medications that may alter gastric motility within two days of the study * use of narcotics or anticholinergics within two days of the study * females on hormone replacement therapy other than birth control medications * pregnancy * intolerance or allergy to any component of gebt test meal * history of neurologic or psychiatric disorders

Keywords: gastroenterology gastric emptying breath test
point-of-care ultrasound for acute kidney injury

Conditions: Acute Kidney Injury

Summary: it is aimed to determine prerenal, renal and postrenal diagnoses of patients with acute kidney injury with pocus performed in the emergency department. patients who presented to the emergency department and who have acute kidney injury (aki) according to the kdigo criteria will be evaluated and patients diagnosed with aki will be included in the study. the diagnostic accuracy of pocus with the aki etiologies of the patients will be evaluated.


Eligibility criteria:
inclusion criteria: • aki diagnosis according to kdigo criteria exclusion criteria: * patients with end stage renal failure, * failure to perform pocus in the first two hours of presentation of patient, * those with renal malignancy, * pregnant women, * renal transplantation patients, * patients with a single kidney, * those with polycystic kidney disease, * patients with nephrostomy, * patients who are referred from another center, * unable to perform adequate imaging, * patients who do not give consent for the study will be excluded.
hiv-1, insufficient sleep and vascular endothelial dysfunction

Conditions: HIV-1

Summary: the investigators hypothesize that chronic insufficient sleep is associated with diminished endothelium-dependent nitric oxide-mediated vasodilation and tissue-type plasminogen activator release in anti-retroviral (art)-treated hiv-1-seropositive adults. furthermore, the investigators hypothesize that the postulated diminishment in endothelial vasodilator and fibrinolytic function with insufficient sleep will be due, at least in part, to increased oxidative stress. moreover, increasing sleep duration and improving sleep quality will increase both endothelium-dependent nitric oxide-mediated vasodilation and endothelial tissue-type plasminogen activator release in art-treated hiv-1-seropositive adults. increases in endothelial vasodilator and fibrinolytic function will be due, at least in part, to reduced oxidative stress.


Eligibility criteria:
inclusion criteria: * subjects will be men and women of all races and ethnic backgrounds aged 40-75 years with documented hiv-1 infection. * subjects will be hiv-1-seropositive individuals on a stable dhhs approved art regimen for at least 6 months, with documented virologic suppression (\<50 copies hiv-1 rna/ml) for at least 3 months. * all subjects must have cd4+ t cell counts \>200 cells/mm3 at the time of study entry. * subjects will be free of overt cvd as assessed by: a) medical history; b) physical examination; c) electrocardiogram and bp at rest and maximal exercise; d) complete blood chemistries, lipid and lipoprotein, glucose, insulin and hematological evaluation. * all candidates will be sedentary as determined from the stanford physical activity questionnaire (\<35 kcal/wk) and will not have engaged in any program of regular physical activity for at least 6 months prior to the study. exclusion criteria: * receiving hormone replacement therapy (hrt) currently or in the preceding 3-year period. * pre- or peri-menopausal women

Keywords: sleep
online yoga vs acceptance and commitment therapy for treating chronic musculoskeletal pain

Conditions: Chronic Pain; Musculoskeletal Pain

Summary: this study will compare online yoga with acceptance and commitment therapy (act), an established treatment for chronic pain. we will compare the efficacy of the two treatments for reducing chronic musculoskeletal pain in veterans.

this study will test if online yoga is not inferior than act for treating chronic pain in veterans. participants will be randomly assigned to receive either online yoga instruction or act, once a week for 12 weeks in an online group class. they will complete self-report questionnaires about their experience of chronic pain. there will be a 6-month follow up period, during which the research team will check in with the participant to record any adverse events and maintain study contact.

Eligibility criteria:
inclusion criteria: * veteran of the united states armed forces ≥ 18 years old * chronic pain \> 6 months related to at least one musculoskeletal pain-related diagnosis indicated by an icd-9 or -10 code * minimum pain intensity at screening ≥4 on a 0-10 using the defense and veterans pain rating scale (dvprs) * not begun new pain treatments or medications in the past month * stable medication regimen for at least 4 weeks prior to entry to the study * english literacy * wireless internet connection at home exclusion criteria: * participation in another clinical trial, unless given prior authorization from both our research team and that of the other study * back surgery within the last 12 months * back pain potentially attributed to a specific known condition * baseline pain \<4 or ≥9 on a 0-10 numeric rating scale * unstable, serious coexisting medical illness, mental illness or psychiatric conditions * attended or practiced yoga ≥ 1 x in the past 12 months * current suicidal intent or plan

Keywords: chronic pain veteran musculoskeletal pain yoga
the effect of two different artificial respiration methods on the intraocular pressure during surgery under general anesthesia

Conditions: Intra Ocular Hypertension

Summary: the purpose of this study is to examine whether the intraocular pressure of operated people under general anesthesia is affected by the artificial respiration method. if it is proven that there is such influence, the findings may lead to select the best method for patients with increased intraocular pressure. in this study, the investigators will monitor the changes observed in intraocular pressure caused during an operation in two different artificial respiration methods: 1. intermittent positive pressure ventilation (ippv) 2. high frequency jet ventilation (hfjv) study recruited 50 patients aged 18 - 40, candidates to elective orthopedic surgery in the limbs. these patients do not suffer from general diseases that restrict their daily functioning. the selection of the type of surgery was done to prevent the involvement of any other factor, except the respiration method, determination of intraocular pressure. exclusion criteria: * patients who are unable to provide an informed consent * patients suffering from any eye disease * patients with corneal thickness less than 450 microns or more than 600 microns * smokers * patients with pulmonary disease restrictive or obstructive * patients using bronchodilator all patients operated under general anesthesia using total intravenous anesthesia )tiva) method. all patients will be resuscitating half of the time of surgery using ippv, and in the second half of surgery using hfjv. during the surgery the iop will be measured by an ophthalmologist who is unaware of the respiration method. correction will be made to the intraocular pressure values, depending on the thickness of the cornea. the results of the measurements will be collected and the clinical significance will be reviewed by acceptable statistical methods.


Eligibility criteria:
inclusion criteria: * patients aged 18 - 40 * patients candidates to elective orthopedic surgery in the limbs * patients do not suffer from general diseases that restrict their daily functioning. exclusion criteria: * patients who are unable to provide an informed consent * patients suffering from any eye disease * patients with corneal thickness less than 450 microns or more than 600 microns * smokers * patients with pulmonary disease restrictive or obstructive * patients using bronchodilator

Keywords: iop
risk factors for multidrug resistant bacteria at icu admission

Conditions: Multi Drug Resistant Bacteria

Summary: the objective of this single-center prospective observational study is to evaluate possible independent risk factors for multidrug-resistant (mdr) bacteria upon icu admission by analyzing comorbidities, epidemiological data, and laboratory/microbiological information of the subjects.

background: infection is one of the main reason for a patient to be admitted to an intensive care unit (icu) and it's fundamental to use the right antibiotic as soon as possible, possibly needing broad-spectrum antibiotics. however, the main problem is that widening the spectrum of drugs will generate pressure on the hospital microbiota, leading to the development of multi-drug resistant bacteria purpose: a large number of icu-admitted patients have infection/sepsis as their major problem, requiring treatment with antibiotics. with knowledge of the presumed risk factors for antibiotic resistance, the assistant physician could use broad-spectrum drugs with greater certainty. objectives: our objective will be to evaluate risk factors for infection caused by multi-drug resistant germs upon icu admission and assess the severity of the disease in comparison to patients infected with susceptible bacteria. ultimately, we aim to develop and validate a clinical tool to assist physicians in selecting the appropriate antibiotic for their patients methods: an observational prospective study with a control group will be conducted, including all patients admitted to the icu with an infectious disease initiated within 48 hours of hospital admission and with a positive microbiologic result. patients with isolation of only susceptible bacteria will be allocated to the control group, while patients with mdr bacteria will be assigned to the study group, referred to as the mdr group. the data to be collected will include sex, age, previous use of antibiotics in the last three months, previous hospital admissions, previous isolation of mdr germs, sensitivity profile of the isolated germs, severity of disease (measured by saps 3), presence of sepsis diagnosis at admission, length of stay in the icu, and 28-day mortality

Eligibility criteria:
inclusion criteria: * all patients admitted to the icu with an infectious disease initiated within 48 hours of hospital admission and a microbiological positive result for bacteria exclusion criteria: * patients with results considered as contamination according to the institutional protocol. * surgical wound and bloodstream infections. * microbiological isolation of only fungi. * vigilance cultures, such as anal, rectal, nasal, and axillary swabs.

Keywords: infection multi drug resistant bacteria risk factors critical care score
group vs. individual cognitive processing therapy for combat-related ptsd

Conditions: Posttraumatic Stress Disorder

Summary: the purpose of this study is to conduct a randomized controlled trial to compare group and individual cpt-c for the treatment of ptsd in oif/oef military personnel.

estimates indicate that between 100,000 and 300,000 operation iraqi freedom (oif) and operation enduring freedom (oef) veterans are at significant risk for chronic post-traumatic stress disorder (ptsd), which can become a chronic disorder that impacts all areas of a person's life. ptsd treatment programs are being developed throughout the department of defense (dod) and the veterans affairs (va), but because of the large number of service members returning from deployment with ptsd, it is often necessary to provide psychotherapy in groups. cognitive processing therapy (cpt), an evidence-based treatment for ptsd, was originally developed as a group-based intervention. however, group-based cpt treatment has never been systematically compared to individual cpt treatment. the public policy implications of the results of this trial are significant. if both treatment formats are equivalent or if group treatment is better, then group treatment would be a more efficient and cost-effective therapy modality in most cases. on the other hand, if individual therapy is found to be superior, the investment of greater resources into individual therapy will be justified in order to provide the most effective treatment for ptsd to military personnel. the purpose of this study is to compare group-administered cpt-cognitive-only version (cpt-c) to individual cpt-c for the treatment of ptsd in oif/oef military personnel. three hundred (300) adult male and female active-duty oif/oef military personnel over 18 years of age will be enrolled into this study. participants will be randomized between group and individual cpt-c.

Eligibility criteria:
inclusion criteria: * adult male and female active duty, activated reservist, or activated national guard oif/oef military personnel or oif/oef veterans seeking treatment for ptsd * diagnosis of ptsd determined by a clinician-administered posttraumatic stress scale (pssi) * person has experienced a criterion a event that is a specific combat-related event or high magnitude operational experience that occurred during a military deployment in support of oif/oef. the diagnosis of ptsd may be indexed to that event or to another criterion a event. * be over the age of 18 * speak and read english * be stable on any psychotropic medications they may be taking. exclusion criteria: * current suicide or homicide risk meriting crisis intervention * active psychosis * moderate to severe brain damage (as determined by the inability to comprehend the baseline screening questionnaires)

Keywords: posttraumatic stress disorder cognitive processing therapy combat military cpt group therapy
upper limb evaluation in non ambulatory patients with neuromuscular disorder

Conditions: Neuromuscular Disorders

Summary: the aim of this study is to evaluate different devices to quantify upper limb function (motriplate) and strength (myogrip, myopinch) in non-ambulatory patients with neuromuscular disorder. motriplate measures the ability of the patient to reproduce a repetitive movement of the wrist to push two 5cm\*5cm targets during 30 seconds. one hundred patients aged 8-30 years and 60 controls will be evaluated during twelve months (m0, m6 and m12) with theses new tools, and results will be compared to other testing, such as wrist, grip and pinch strength, taping, mfm measurement, and self evaluation of hand ability.


Eligibility criteria:
inclusion criteria: * confirmed neuromuscular disorder * aged 8-30 years * written consent * non ambulant exclusion criteria * major cognitive impairment * inability to stay seated one hour * recent upper limb surgery or trauma * treatment by steroids initiated less than 6 months before

Keywords: neuromuscular disorders evaluation strength upper limb
resection for multiple hepatocellular carcinomas (hcc)

Conditions: Hepatocellular Carcinoma; Multiple Tumors; Cirrhosis

Summary: surgical resection in patients with multiple hepatocellular carcinomas (hcc) remains controversial. the aim of this study was to investigate the outcome of a consecutive cohort of patients resected for multiple hcc, without macrovascular invasion, in order to identify clinically reliable parameters to select patients for surgery.


Eligibility criteria:
inclusion criteria: * patients with multiple hcc without macrovascular invasion on liver cirrhosis exclusion criteria: * macrovascular invasion; * normal liver; * distant or lymphnodes metastasis

Keywords: liver resection hepatic resection intraoperative ultrasound