Kornimate/medical-research-clean huggingface dataset:
rpfna assessment of exercise effect in breast cancer

Conditions: Breast Cancer

Summary: this study is being done to see if the investigators can measure changes that occur in breast tissue when women at risk of developing breast cancer start an exercise program. the investigators are interested in studying this because research shows that women who exercise regularly are less likely to develop breast cancer, but there is not very much information explaining how exercise could affect breast cells in a way to prevent cancer from occurring. in this research study the investigators will use a research technique called breast random fine needle aspiration (rpfna) to test breast cells for their shape and how they look. the investigators will look at breast cells before and after a participant takes part in an exercise program to see if the investigators are able to see any changes in breast cells that could have happened due to the exercise program. this research will help us to develop larger projects to see if exercise programs could be helpful in preventing breast cancer.


Eligibility criteria:
inclusion criteria: * history of lobular carcinoma in situ, atypical ductal/lobular hyperplasia on prior breast biopsy or lifetime risk of breast cancer of at least 20% based on any risk model, or personal history of brca1 or 2 mutation * physically able to exercise and physician consent to start an exercise program * sedentary activity pattern * premenopausal * english speaking and able to read english exclusion criteria: * history of invasive breast cancer or ductal carcinoma in situ * absolute contraindications to maximal exercise testing as recommended by the american thoracic society * any condition which in the investigator's opinion makes the subject unsuitable for study participation * participating in another clinical study with competing study outcomes * pregnant or breastfeeding * unable to comply with protocol and/or not available for follow-ups * type ii diabetes * allergic to local anesthetics * history of bilateral or unilateral mastectomy

Keywords: high risk
maternal periodontal status and cytokines in preeclampsia

Conditions: Preeclampsia; Periodontal Diseases

Summary: background: the purpose of this study is to examine the relationship between maternal preeclampsia and periodontal parameters and the correlation of these two disorders with maternal gingival crevicular fluid levels (gcf) of interleukin (il)-35, interleukin-37 and interleukin-6. the investigators also investigated their relation to the severity of preeclampsia. methods: 82 preeclamptic women were recruited to the study (29 healthy pregnant women, 30 mild preeclamptic patient, 23 severe preeclamptic patient ). the clinical periodontal parameters and gcf samples were collected in the first day of puerperium.


Eligibility criteria:
inclusion criteria: * aged between 18 and 45 years * 25 and 40 weeks of gestation. * healthy pregnants, mild and severe preeclampsia exclusion criteria: * patients with accompanying diseases * multiple gestations * congenital abnormalities were excluded from the study.
determination of threshold values of aldosterone in hplc-ms/ms, of renin and of the aldosterone / renin ratio for the diagnosis of primary hyperaldosteronism

Conditions: Hyperaldosteronism; Primary

Summary: collaborative work within 2 hospitals at the chu of caen, at the chru of lille, concerning the evaluation of the biological markers of primary hyperaldosteronism (pah) with the dosage of aldosterone in lc -ms/ms, which is performed in both centers, with two different techniques. the main objective is to define the range of aldosterone concentrations in lc ms/ms, of renin in an automated method, in populations of healthy volunteers, essential hypertensives, and hypertensives with primary hyperaldosteronism. , in order to establish a threshold for the screening of pah by the rar, and for the confirmation of pah by a dynamic test with an aldosterone threshold post salt load test.


Eligibility criteria:
inclusion criteria: * patients (18-75 years old) with moderate to severe hypertension, which justifies carrying out an etiological assessment in a hospital environment. * assessment carried out in compliance with the standardized measurement conditions of the rar defined by the sfe consensus, * signature of a written consent by the patient exclusion criteria: * patient on antihypertensive treatment other than alpha-blockers, calcium channel blockers or centrally acting antihypertensive * etiology of secondary hypertension other than pah
peer comparison-based risk communication

Conditions: Diabetes Type 2

Summary: the study objective is to evaluate the feasibility of delivering a risk communication intervention, peer comparison-based risk communication (pricom), in the primary care setting for adults with poor t2dm control. findings from the study will inform further revisions to pricom and provide an estimated effect size to estimate the required sample size for a multi-site trial.

background: younger adults with type 2 diabetes mellitus (t2dm) in singapore tend to have poorer glycaemic control and medication adherence, factors correlating with high risk of diabetes complications. late-stage diabetes and its complications are perceived to be slow-progressing and not immediately life-threatening. these reflect a concerning state of diabetes control and risk perception in singapore. using the health belief model, a risk communication intervention, peer comparison-based risk communication (pricom), was developed for physicians to counsel patients with t2dm supported by a digital tool. pricom aims to promote health actions by increasing their risk perceptions of diabetes complications. specific aims: the primary aim is to evaluate the feasibility of delivering pricom in the primary care setting for adults with poor t2dm control - in terms of recruitment, retention, pricom adherence, estimated effect size of score changes in risk perception, health actions and hba1c change. secondary aims are to assess validity of the risk perception scale, and to explore patients' perspectives of pricom. methodology: a multi-site randomised controlled trial will be conducted at a primary care clinic in 2 concurrent phases. in phase 1, content validation and test-retest reliability of a risk perception scale will be carried out. in phase 2, a two-arm randomised controlled trial will be conducted using mixed-methods to evaluate the feasibility of delivering pricom. a total 40 patient participants will be recruited by convenience sampling. eligible patients must be age 40-79 years and have poor t2dm control with at least one hba1c reading ≥ 8.0% within the last 6 months. relevance/significance of the study: findings from the study will inform further revisions to pricom and provide an estimated effect size to estimate the required sample size for a multi-site trial.

Eligibility criteria:
eligibility criteria for patient participation: * t2dm on follow-up at the respective study site for at least 12 months * age 40 to 79 years * at least one hba1c reading ≥ 8.0% within the last 6 months * able to read and speak english exclusion criteria for patient participation: * not a singapore citizen or permanent resident * pregnant * end-stage kidney disease or on renal replacement therapy * known terminal illness * visual and/or hearing impairment * cognitive impairment or mental illness * unable to provide informed consent
feasibility study: lifting and tightening neck skin in patients

Conditions: Skin Laxity

Summary: up to 30 subjects will be enrolled. all subjects will receive one ultherapy treatment to the lower two thirds of the face and neck. subjects will be equally grouped into those with a history of submentoplasty and or rhytidectomy and those naive to submentoplasty and or rhytidectomy. follow-up visits will occur at 14, 30, 60, 90 and 180 days following treatment. study images will be obtained pre-treatment, 30-60 minutes post-treatment, and at each follow-up visit.

this is a prospective single center study. subjects will be enrolled one per group as they present. efficacy will be determined by the change in submental volume and cervicomental angle. gais and patient satisfaction questionnaires will also be obtained.

Eligibility criteria:
inclusion criteria: * male or female, aged 30 to 65 years * subject in good health * body mass index of less than 30 * present with unwanted skin laxity in the submental area as demonstrated by a grade 2 or 3 on the knize scale for classification of cosmetic deformity of the cervicomental angle * previous history of surgical submentoplasty and or rhytidectomy greater than 12 months previous to enrollment and not to exceed 120 months prior to enrollment * understands and accepts the obligation not to receive any other procedures in the submental areas thru the 6 month follow up visit * willingness and ability to comply with protocol requirements including returning for follow-up visits and abstaining from exclusionary procedures for the duration of the study * subjects of childbearing potential must have a negative urine pregnancy test result at visit 1 and be willing able to use an acceptable method of birth control exclusion criteria: * pregnant, lactating or planning to become pregnant and or not using a reliable form of birth control * has an active systemic or local skin disease that may alter wound healing * subjects with a prior cosmetic or medical history of submentoplasty and or rhytidectomy within the last 12 months or greater than 120 months * subjects with a prior cosmetic or medical history of submentoplasty and or rhytidectomy

Keywords: ulthera® system ultherapy™ treatment ulthera, inc. ultrasound treatment for skin tightening
arthroscopic debridement vs arthroscopic hemi-trapeziectomy on patients with thumb carpometacarpal joint osteoarthritis

Conditions: Osteoarthritis Thumb

Summary: patients with thumb carpometacarpal joint osteoarthritis usually suffer from pain, joint enlargement, inflammation, deformity and loss of function. conservative treatments usually are the first-line interventions, unfortunately some of the patients do not response to such treatments and surgical treatment will then be considered. compare to other traditional surgical techniques, arthroscopic techniques has resulted in the potential to treat osteoarthritis in a minimally invasive approach, avoiding the need for a larger incision. other advantages of arthroscopy include less scarring and joint contracture, less risk of neurovascular injury, improved appearance, limited morbidity and quicker recovery. although arthroscopic methods have been proved to be effective, there is lack of high-level evidence based studies to conclude one operation is superior to another. hence, this study is designed to investigate outcomes of the two arthroscopic surgical methods (arthroscopic debridement vs arthroscopic hemi-trapeziectomy with mini tightrope). the result of this study is expected to provide significant evidence based clinical data for surgeons worldwide on treating the thumb carpometacarpal joint osteoarthritis.


Eligibility criteria:
inclusion criteria: * patients with eaton and glickel stage ii and iii of thumb carpometacarpal joint osteoarthritis * age≥18 years old * failed to response to nonsurgical/conservative treatments including orthoses/splinting, activity modification, oral analgesics (e.g. nonsteroidal anti-inflammatory drugs), strengthening/flexibility exercises, and injections of corticosteroid or hyaluronic acid * willing to receive surgery exclusion criteria: * patients received previous thumb surgery proximal to the interphalangeal joint (ipj) * patients with prior traumatic thumb injuries (e.g. fracture, dislocation) * patients with significant metacarpophalangeal joint (mcpj) pain * with concurrent procedures on the thumb, e.g. ganglion removal, trigger thumb release
feasibility of music therapy for spontaneous breathing trials

Conditions: Spontaneous Breathing Trial; Intubation; Mechanical Ventilation; Music Therapy

Summary: in this study, the investigators will study music therapy for patients during breathing trials, a procedure performed in intensive care units. participants will be assigned either to standard medical care or standard medical care plus music therapy. participants have a 50/50 chance (like flipping a coin) of being in either group. in the music therapy group, a board-certified music therapist will sing softly with guitar accompaniment to provide music during the breathing trial. the music is in addition to the usual treatment provided by hospital staff. participants in the standard medical care group will receive the usual medical care given by hospital staff members. information will be collected from participant's charts and by observation of vital signs during the breathing trial.


Eligibility criteria:
inclusion criteria: * adults 18+ * admitted to musc's main hospital medical intensive care unit (micu) or ashley river tower medical-surgical intensive care unit (msicu) * intubated and will undergo a spontaneous breathing trial exclusion criteria: * patients who have had any prior sbts * patients known to have a neurological injury * patients who are known to be deaf * patients whom (or whose lar) are unable or unwilling to give informed consent.
association between deficiency of mbl (mannose-binding lectin) and polymorphisms in mbl2 gene to urinary tract infection

Conditions: Recurrent Urinary Tract Infections

Summary: due to genetic polymorphism about 15%-30% of the world population have low levels of mbl (mannose binding lectin) in serum (below 500ng/ml). different studies reported correlation between polymorphism in the mbl gene with low levels of mbl in serum and higher frequency of recurrent infections, severity of sepsis, ards and other infections. urinary tract infection (uti) is one of the very common infection in women. since mbl is part of the innate immunity and there are proofs of relation between patients with recurrent infections and lack of mbl, we decided to explore a possible relation between low levels of mbl and different genotypes of mbl in young women and the risk to develop recurrent uti.


Eligibility criteria:
inclusion criteria: * women above 18 years old. * premenopausal * recurrent uti exclusion criteria: * pregnancy * immunocompromised * active malignancy * hiv carrier

Keywords: mbl, uti
comparison effectiveness analysis between acl reconstruction and rehabilitation in peripheral and main capital in indonesia

Conditions: ACL Tear

Summary: the study was a prospective observational analysis of cases with complete acl tears. a study was conducted between february 2021 to december 2024. all the patients attending those hospitals' emergency or outpatient departments (opd) with knee injuries were evaluated for an acl tear. patients who meet inclusion criteria and consent to participate in the study will be observed for two years. patients in arifin achmad hospital pekanbaru will follow rehabilitation treatment and optional delayed reconstruction after 12 weeks if needed, while patients in some hospitals in jakarta and bandung (cipto mangunkusumo hospital, gatot subroto army hospital, hasan sadikin hospital) will perform early reconstruction treatment. after receiving informed consent, all subjects received a self-administered patient questionnaire containing the international knee documentation committee (ikdc) score, eq5d3l, and tegner activity level (tal) scores. these questionnaires will be measured at 0, 12, 24, 48, and 96 weeks. clinical value of the lachman test and pivot shift test will be performed. one independent orthopedic surgeon will keep all records and evaluate the results. all costs for the treatment will be accounted for.


Eligibility criteria:
inclusion criteria: 1. age between 18 to 40 years 2. either sex 3. isolated acl tear not more than six weeks old to a previously uninjured knee or less than six months with showing acute symptoms (inflammation, swelling, knee effusion) 4. tegner activitiy level of 5-9. exclusion criteria 1. professional athletes or military 2. collateral ligament rupture 3. full-thickness cartilage lesion visualized 4. tal below 5 5. meniscal tear grade iii on mri. 6. pregnancy 7. a history of deep vein thrombosis (dvt) or a disorder of the coagulative system 8. claustrophobia 9. general systemic disease affecting physical function, any other condition or treatment interfering with the completion of the trial, including patients with metal devices or motion disorders 10. hyperlaxity with a beighton score of more than 4
safety and tolerability of subcutaneous manp in difficult to control/resistant hypertensive subjects

Conditions: Resistant Hypertension; Difficult to Control Hypertension

Summary: a randomized, double-blind, placebo-controlled multiple ascending dose study in hypertensive subjects on stable doses of at least three hypertensive drugs for at least 6 weeks prior to screening. the study will consist of screening, pk-unit admittance, and safety follow up periods. subjects will be randomized at a 6:2 ratio of either manp or placebo and will be stratified by race in each dosage cohort. the entire first cohort will be given the lowest dosage with subsequent cohorts progressing sequentially to the higher doses depending on safety and tolerability of the previous cohort. endpoints not related to the safety reviews will be analyzed after the last patient last visit (lplv).


Eligibility criteria:
inclusion criteria: * dtc/rh diagnosed with clinic sbp ≥140 mmhg or dbp ≥ 90 mmhg (or sbp ≥ 130 mmhg or dbp ≥ 80 mmhg for diabetics) while on at least three standard-of-care antihypertensive medications (which must include a diuretic). * mdrd egfr ≥ 30 ml/min. * men and women between the ages of 18 - 80. * bmi within the range of 18-40 kg/m2. * women of childbearing potential must not be pregnant and agree to avoid becoming pregnant while receiving study treatment and for 14 days after the last study visit. exclusion criteria: * hba1c ≥ 8% at screening. * use of other investigational drugs within 30 days of screening or foreseen use during the study. * inability to comply with study requirements as judged by the investigator. * pregnant and/or breastfeeding. * any disease or condition (medical or surgical) which, in the opinion of the investigator, might compromise the hematologic, cardiovascular, pulmonary, renal, gastrointestinal, hepatic, or central nervous system; or other conditions that may interfere with the absorption, distribution, metabolism or excretion of study drug, or would place the subject at increased risk.
effects of mackenzie extension and william flexion exercises in lumbo-sarcal radiculopathy

Conditions: Lumbosacral Radiculopathy

Summary: lumbosacral radiculopathy (lr) is among most common disorder caused due to irritation or compression of nerve pathway leading to symptoms of pain, numbness and tingling sensations along the nerve root. lumbosacral radiculopathy consists at any lumbar region including l1-s1. occurrence rate of lumbosacral radiculopathy is 3-5% distributed equally in men and women affecting more men than women. it commonly occurs in late 40s in men and late 50s-60s in females. men are more prone to develop lumbosacral radiculopathy due to mechanical disturbance during routine work.

* william flexion exercises: exercises for strengthening of gluteal and abdominal muscles which help to reduce pressure on the nerve root by promoting flexion at lumber spine such as knee to chest, double knee to chest, bridging(gluets bridge), and straight leg raise (slr). * mckenzie extension exercises: the exercises used to create space between under lying structures of lumber spine which help centralization of pain and can be performed in prone lying such as prone press ups, prone on elbow, and head lift in prone a randomized controlled trial. group 1 group 2 55 patients 55 patients standard treatment: tens (4-pole) + hot pack for 15 minutes standard treatment: tens (4-pole) + hot pack for 15 minutes new intervention: mckenzie extension * prone press-ups * head life in prone * prone on elbow * prone on hands * prone on pillow new intervention: william flexion * single knee to chest * double knee to chest * straight leg raise * bridging * pelvic tilt each exercise will be repeated 5 minutes with 10 seconds hold and 5 sec rest. the duration of intervention will be four weeks, 3 sessions a week on alternate days and total of 12 sessions will be given. data will be collected in three phases pre-treatment at end of second week and at the completion of treatment time i.e end of 4th week.

Eligibility criteria:
inclusion criteria: * • males and females with age between 40-60 years * patients referred from neuro and orthopedic departments with diagnosed lumbosacral radiculopathy. * complaint of low back pain on walk, bending and after long sitting with positive slump test. * complaint of low back pain, and numbness and tingling in leg with positive slr test exclusion criteria: * • lumbar trauma * any other orthopedic and neurological conditions of hip and lumbosacral spine. * hip fracture * malignancy
safety and efficacy study of antiviral local application to treat high grade cervical intraepithelial lesions (cin2/3)

Conditions: Uterine Cervical Neoplasia; Cervix Intraepithelial Neoplasia

Summary: the purpose of this phase-ii study is to evaluate the efficacy and safety of an aqueous gel containing an antiviral, administered directly on cervix exhibiting high grade squamous or glandular intraepithelial lesion (cin 2 and 3) in comparison with a placebo treatment.

human papilloma virus (hpv) infections induce cervical intraepithelial neoplasia (cin) of cervix. to reduce incidence of invasive tumor associated with high grade cin lesions, the standard treatment is the conisation of cervix (surgical act). a local treatment with antiviral would preserve the cervix of young subjects and reduce obstetrical morbidity induced by the conisation. this clinical study is aimed at: * to evaluate the efficacy of a gel with antiviral directly applied on the cervix exhibiting high grade cin lesions (cin2/3): conisation is still indicated? * to evaluate the safety and tolerance after local application.

Eligibility criteria:
inclusion criteria: * women aged between 18 and 50 years old * informed consent signed * cervical lesion classified cin 2 or 3, on a biopsy made during the 60 days before inclusion * no sexual activity, or proved sterility, or use of effective mechanical, hormonal or intrauterine contraception during 30 days following inclusion (except vaginal ring nuvaring, diaphragm and spermicide) exclusion criteria: * invasive or microinvasive cervical neoplasia * pregnancy or breast feeding * subtotal hysterectomy * current renal impairment * current immune disorder including serology hiv + * current use of drugs interfering with renal function * current use of oncologic treatment * current use of immune treatment * current use of anti-viral treatment * current vaginal application of drugs or cosmetics * prior treatment with the antiviral on the cervix * local or general condition incompatible with the experimental treatment in the opinion of the principal investigator * current or recent participation to another experimental study during the last 3 months before the screening visit