Kornimate/medical-research-clean huggingface dataset:
tracheal colonization and outcome after major abdominal cancer surgery

Conditions: Colorectal Neoplasms Malignant; Surgical Procedures, Operative; Stomach Neoplasms; Pancreatic Cancer, Adult

Summary: the goals of this study were to investigate whether two anesthesia regimens, with and without n2o, and bacterial colonization influence respiratory complications after major abdominal surgery for cancer.

a study was approved by institutional ethics committee. all patients were informed on the study protocol by attending anesthesiologist on the day of the surgery and written informed consent was obtained. patients with clinically or radiologically confirmed acute respiratory infections or those using antibiotics due to the respiratory infections a week prior to the surgery were not included in the study. following risk factors were recorded in all patients: age, sex, weight loss in the last 6 months, comorbidities and operative time. comorbidities were rated using asa status and charlson comorbidity index by 3 independent observers. charlson comorbidity index was calculated after pathological examination. an advanced malignant disease was considered if tumor had infiltrated other organs or surrounding tissues, or when positive lymph nodes or metastases were confirmed. a group of 120 colorectal, gastric, or pancreatic cancer patients scheduled for surgery in the single centre were included in the prospective randomized study regardless of their asa physical status. nasopharyngeal smears were obtained in the preoperative area and tracheal aspirates were obtained in the operating room at the end of the surgery with a sterile suction catheter in a closed system. postoperative hgb; crp and lung auscultation were done in all patients on the second and fourth postoperative day. outcome measures registered were: * postoperative pneumonia * productive and difficult cough * dysphonia * congestive heart failure * postoperative complications, including hypertensive crisis, thromboembolic and infective complications were summarized one year after surgical treatment was finished \& one year survival

Eligibility criteria:
inclusion criteria: * adult patients diagnosis of gastric cancer, or colorectal cancer or pancreatic cancer * scheduled for major abdominal surgery with organ resections * written informed consent * nasopharyngeal smears taken in the preoperative area * tracheal aspirates taken at the end of the surgical procedure exclusion criteria: * patients unable to understand study protocol and patients who refused study participation at any time * patients with clinically or radiologically confirmed acute respiratory infections at admission * antibiotic therapy due to the respiratory infections a week prior to the surgery

Keywords: tracheal colonization; bacteria; survival anesthesia, general;
evaluation of monocyte volume distribution width (mdw) for early detection of sepsis

Conditions: Sepsis; Severe Infection

Summary: the measurement of monocyte volume width distribution (mdw) is intended for use with adult patients presenting to the emergency department (ed), where a cbc with differential has been ordered, as an aid in the early detection of patients with or developing sepsis. the study will establish the clinical performance of mdw for detection of sepsis in the ed.

a prospective multi-center study to establish the clinical utility of the measurement of monocyte volume width distribution, a cell population parameter of the cbc-differential, on the beckman coulter unicel dxh analyzers. the study will validate the cut-off for the early detection of sepsis in an adult emergency room population where the standard of care included a cbc with differential and will evaluate the diagnostic performance of the parameter.

Eligibility criteria:
inclusion criteria: * adults (18-89 years) presenting to ed * all races \& ethnicities * cbc with differential performed upon presentation * subjects with at least 12 hours of follow-up in ed (or in-patient if admitted) exclusion criteria: * previously enrolled * subjects discharged \<12 hours form ed presentation
prospective validation of the rox index

Conditions: Validation

Summary: we recently described the rox index, defined as the ratio of spo2/fio2 to respiratory rate that outperformed the diagnostic accuracy of the two variables separately. patients who had a rox index ≥4.88 after 12 hours of hfnc therapy were less likely to be intubated, even after adjusting for potential covariates. like any other scoring system, an independent validation of the score in a different population is necessary. we therefore undertook a multicenter, prospective study to validate the rox index's diagnostic accuracy for determining which patients will fail on hfnc and will need to be intubated.

a growing interest in the non-invasive management of acute respiratory failure has been fuelled by the advent of high-flow nasal canula oxygen therapy (hfnc) and recent data showing that use of hfnc was associated with lower mortality, more ventilator-free days and lower risk for intubation in subsets of patients with pao2/fio2≤200mmhg or in those who were immunocompromised in comparison with non-invasive ventilation or standard oxygen. these positive results in favour of hfnc followed physiological studies indicating oxygenation and comfort improvements associated with hfnc use. this has led clinicians to try this technique in the most severe respiratory failure patients, those with ards. consubstantial to the increasing use of hfnc is the risk of delaying intubation. this is a major concern since a large body of evidence has shown that patients that fail non-invasive ventilatory management of de novo acute respiratory failure (arf) have a worse outcome. the variability in both the decision to intubate and its timing reported in several studies suggest that clinical parameters such as respiratory parameters alone are not sufficient and that the progression of the respiratory failure is not sufficiently taken into account. to address this need, we investigated a new score to identify patients at risk of intubation to help clinicians, with three goals simple to use, accurate, and immediately performable at the patients' bedside by any staff.

Eligibility criteria:
inclusion criteria: - all consecutive patients admitted to the icu with pneumonia and treated with hfnc were included exclusion criteria: * patients younger than 18 years old * patients with indication for immediate intubation * patients with limitation of therapeutic effort * patients electively intubated for diagnostic or therapeutic procedures

Keywords: high-flow nasal cannula, hfnc, acute respiratory failure, intubation
comparison of lung ultrasound scores with clinical models for predicting bronchopulmonary dysplasia：a multi-center prospective cohort study

Conditions: Lung Ultrasound; Bronchopulmonary Dysplasia

Summary: this study aimed to fill this knowledge gap and designed a multicentre cohort study to verify the hypothesis that lus has good reliability to predict bpd in china and to compare the predictive value of lus and clinical models for the development of bpd at different time points in infants born before and after 28 weeks.


Eligibility criteria:
inclusion criteria: 1. preterm infants with ga \<32 weeks. 2. infants with enrollment within 24 hours from birth 3. parental written consent is obtained. exclusion criteria: 1. complex congenital malformations or chromosomal abnormalities 2. congenital lung diseases or congenital heart defects 3. infants with enrollment after 24 hours from birth
auriculotherapy during medication abortion

Conditions: Abortion Early

Summary: this randomized trial will evaluate the effect of adding auriculotherapy (i.e. acupuncture applied to the ear) using either gold beads or pyonex needles in addition to usual care for the relief of pain and anxiety during medication abortion. the control group will receive placebo auriculotherapy plus usual care. participants will receive the assigned treatment immediately after they receive their initial abortion medication. the investigators will assess pain and anxiety via text message once daily for four days, and in person at a one-week follow-up visit.

most women undergoing medication abortion with mifepristone and misoprostol report moderate to severe pain, despite treatment with ibuprofen or opioids. in 2018 national academies of sciences, engineering and medicine (nasem) recommended research to improve pain relief. limited data indicate that acupuncture is valuable for dysmenorrhea and for labor pain, conditions in which pain may be similar to that experienced during medication abortion. this randomized trial will recruit women seeking medication abortion after they have completed their routine clinical assessment and after they have received mifepristone. this study will evaluate two types of auriculotherapy applied to selected acupoints on the external ear. the study treatments are acupuncture using pyonex needles and acupressure using gold pellets; both are applied to the ear using adhesive disks. a control group will receive the adhesive disks alone. all participants will receive usual medication abortion care, including taking misoprostol 1-3 days after mifepristone and ibuprofen for pain management. the investigators will query the participants regarding pain and anxiety. follow-up will end at the time of the usual clinical follow-up about one week after mifepristone administration.

Eligibility criteria:
inclusion criteria: * pregnant up to 10 weeks (70 days) gestation * seeking medication abortion with mifepristone and misoprostol * initial clinical care completed and mifepristone administered * english- or spanish-speaking * able to use a mobile phone for follow-up on days 1-4 exclusion criteria: * not a candidate for medication abortion for any reason * allergy to adhesives
combined amiodarone and electrical cardioversion for postoperative atrial fibrillation after cardiac surgery

Conditions: Cardiac Disease

Summary: to determine the efficacy of cardioversion and amiodarone for cardiac patients who develop postoperative atrial fibrillation

new-onset atrial fibrillation (af) after cardiac surgery is a well-recognized phenomenon with significant outcome implications. incidence after coronary artery bypass grafting (cabg) is estimated at 26-33%, while those undergoing valvular surgery bear a greater burden at 33-49%. clinical and socioeconomic complications resulting from postoperative atrial fibrillation include an increased risk of death (10%), congestive heart failure (4%), prolonged hospital stays, and increased rate of discharge to care facilities over those who remain in sinus rhythm, (7%). although a body of evidence exists for electrical or pharmacological cardioversion to sinus rhythm postoperatively, there is a marked paucity in the literature regarding efficacy and outcomes combining the two. more specifically, we seek to evaluate the efficacy of dc cardioversion when combined with amiodarone. improved outcomes with multimodal cardioversion may decrease the postoperative clinical burden of atrial fibrillation on cardiac surgery patients.

Eligibility criteria:
inclusion criteria: * subjects who underwent cabg and/or cardiac valve surgery involving cardiopulmonary bypass and develop postoperative atrial fibrillation within 7 days after surgery exclusion criteria: * subjects who had any form of atrial fibrillation prior to surgery * subjects who were on antiarrhythmic medications preoperatively, including but not limited to procainamide and amiodarone
manage-dm: novel nurse case management to improve diabetes outcomes in formerly incarcerated black men

Conditions: Diabetes Mellitus, Type 2

Summary: the study is a randomized control trial involving 100 participants (formerly incarcerated black men with poorly controlled diabetes) to examine the effect of a tailored nurse case manager on glycemic control and other clinical outcomes, self-care behaviors, and quality of life at 6 months post-randomization.

the study is a randomized control trial involving 100 participants (formerly incarcerated black men with poorly controlled diabetes) to examine the effect of a tailored nurse case manager on glycemic control and other clinical outcomes, self-care behaviors, and quality of life at 6 months post-randomization. participants assigned to manage-dm will receive the standard diabetes education mailing in addition to a novel nurse case management intervention. nurse case managers are trained rns who support patients with t2dm by coordinating services, supporting self-care and implementing disease management strategies (welch 2010). manage-dm will include ncm services tailored to the health needs of black men with recent release from incarceration and t2dm. manage-dm will include three components: 1) diabetes education and skills training; 2) healthcare navigation and 3) basic needs navigation. the ncm will serve as an adjunct to the participant's primary care provider; they will not be embedded within a clinic but instead interact with the participant over the phone after study recruitment from a community setting.

Eligibility criteria:
inclusion criteria: * age ≥18 years * identify as black or african american * identify as male * formerly incarcerated in a state or federal prison system or county jail * clinical diagnosis of type 2 diabetes with hba1c ≥8% at the screening visit * able to communicate in english. exclusion criteria: * mental confusion on screening interview suggesting significant dementia * current participation in other diabetes clinical trials * active psychosis or acute mental disorder * life expectancy \&lt;12 months * awaiting arraignment, trial, sentencing in the criminal legal system * on active surveillance by the criminal legal system, meaning on house arrest or subject to electronic monitoring
dutch national prospective emr cohort

Conditions: Large Bowel Polyp

Summary: a prospective study: longterm follow up until s2 (2nd surveillance) at 18 months after emr for large flat/sessile colonic polyps.


Eligibility criteria:
inclusion criteria: * flat or sessile polyp morphology (paris classification 0-iia/b/c, is) * polyp size \>20 mm * therapy: emr * age \> 18 years old * written informed consent exclusion criteria: * participation in a competing study, such as the "clipper trial" (registration number: nl62949.091.17).
efficacy and safety study of haporine-s for treatment of moderate to severe dry eye syndromes

Conditions: Dry Eye Syndromes

Summary: the purpose of this study is to determine efficacy and safety of haporine-s eye drop for the patients with moderate to severe dry eye disease in a multicenter phase iii clinical trial.

this study is to compare the efficacy and the safety of topical haposine-s and restasis® eye drop 0.05% for the patients with moderate to severe dry eye disease in a multicenter, investigator(assessor) blind, parallel design, non-inferiority phase iii trial. primary outcome is the change of corneal staining score(oxford scheme) at 12 weeks from baseline.

Eligibility criteria:
inclusion criteria: * male or female, age 20 or over * patients with moderate to severe dry eye(dews level ii or over) * be informed of the nature of the study and will give written informed consent exclusion criteria: * being treated with steroidal eye drop or non-steroidal anti-inflammatory eye drop for dry eye * being treated with systemic steroid or immunosuppressive * history of eyeball surgical operation within 6 months * wearing contact lenses during participation of the study * pregnancy or breastfeeding * use of cyclosporine eye drop within 2 weeks * intraocular pressure(iop)\> 25 mmhg * history of punctal occlusion within 1 month or during participation of the study * hypersensitivity to the investigational products or be suspicious to them * patients whom the investigator considers inappropriate to participate in the study

Keywords: dry eye syndromes
topical cp-690,550 for chronic plaque psoriasis

Conditions: Psoriasis

Summary: study will test effectiveness of an experimental drug applied once or twice daily to two psoriasis plaques. requires 1 clinic visit each week for 5 weeks.


Eligibility criteria:
inclusion criteria: * having chronic plaque psoriasis for at least 6 months * able to withdraw all prior psoriasis treatments * must agree to avoid prolonged exposure to the sun and avoid use of tanning booths or other ultraviolet light sources during the study exclusion criteria: * evidence of active, latent, or inadequately treated infection with mycobacterium tuberculosis * pregnant or lactating women * unwilling to use appropriate contraceptive methods

Keywords: chronic plaque psoriasis topical treatment
the symptom experience of women with perimenstrual syndrome;women's health related quality of life.

Conditions: Premenstrual Syndrome

Summary: the purpose of these series research project is to investigate the prevalence, symptoms cluster and characteristic; establish the systemic symptom management nursing strategies (pms-smp); determine short-and long-term effectiveness of pms-smp. to enhance the health related quality of life of women with perimenstrual syndrome. simultaneously, the pms-smp offers a research and clinical based protocol to demonstrate the independent nursing role and practice care model. the 3-year series research process will include three research domains.

symptoms are the most common reason people seek health care. although the menstrual cycle, a normative process, but 10\~15% of western women experience sever recurring symptoms associated with the menstrual cycle that can be considered a chronic illness. there are many interventional researches focus on this issue in western countries. there is not only lack of evidence base prevalence of perimenstrual syndrome, but also never found any nursing intervention project focusing on women with perimenstrual syndrome. the purpose of these series research project is to investigate the prevalence, symptoms cluster and characteristic; establish the systemic symptom management nursing strategies (pms-smp); determine short-and long-term effectiveness of pms-smp. to enhance the health related quality of life of women with perimenstrual syndrome. simultaneously, the pms-smp offers a research and clinical based protocol to demonstrate the independent nursing role and practice care model. the 3-year series research process will include three research domains. content analysis, descriptive statistics(percentage, mode, medium, quartile, rank), chi-square, one way anova, mancova, and step-wise regression will be applied to examine the research finding. although focused on perimenstrual symptoms relief and improve the health related quality of life of women with perimenstrual symptoms, these strategies are generally health promoting and can be applied to other women's health conditions.

Eligibility criteria:
inclusion criteria: * female exclusion criteria: * pregnancy,menopause,woman with breast-feeding

Keywords: premenstrual syndrome,health related quality of life
symptom adapted therapy in gerd patients

Conditions: Gastroesophageal Reflux Disease

Summary: the purpose of the study is to determine whether a maintenance treatment over 12 weeks with esomeprazole 20 mg daily will sufficiently give control over gerd symptoms and how it compares either with an on-demand therapy with esomeprazole 20 mg or an as needed therapy (wait and see regimen) with rescue medication only (antacid), following a 4-weeks acute treatment phase with either esomeprazole 20 mg or esomeprazole 40 mg.


Eligibility criteria:
inclusion criteria: * signed informed consent * patients who seek medical advice in primary care for symptoms thought to be gerd-related exclusion criteria: * clinical gerd diagnosis/treatment within last 3 month * history of severe esophagitis (i.e. la grade c or d) * previous anti-reflux surgery * history of drug abuse * female patients who are pregnant or lactating or at risk of pregnancy

Keywords: nexium
development and validation of a mindfulness intervention for problem gambling: an exploratory study

Conditions: Gambling

Summary: in recent years, mindfulness meditation has been shown to be a promising approach for alleviating emotional distress associated with chronic medical and psychiatric conditions and in reducing relapse following treatment for depression. the applicability of mindfulness meditation to problem gambling has not yet been explored. mindfulness meditation may be particularly suitable for this clinical disorder as it stresses a process-oriented, metacognitive, approach to cognitive pathology in contrast to a content-focused approach, characteristic of traditional approaches to treating cognitive psychopathology. gambling-related cognitive psychopathology is a well-known characteristic of problem gambling and frequently the target of therapy. although there is growing evidence that cognitive-behavioral treatments are effective for gambling, outcomes may be improved by teaching gamblers additional ways to cope with cognitive distortions that emphasize metacognitive processes.

hypothesis the mindfulness-enhanced cbt (mcbt) will report significant reductions in the frequency of gambling, gambling urges, gambling cognitions and gambling-related expenditures compared to the relaxation-enhanced cbt (rcbt) at end-of-treatment and at the 3-month follow-up. significance 1. feasibility of mindfulness interventions for problem gamblers 2. tentative data for the effectiveness of the intervention 3. an additional clinical tool to treat problem gamblers 4. basis of a larger, grant-funded study obtain more definitive data

Eligibility criteria:
inclusion criteria: * current diagnosis of pathological gambling * willingness to practice mindfulness or relaxation exclusion criteria: * substance abuse/dependence (except nicotine) * concurrent attendance at any treatment in which their gambling is addressed (including gamblers anonymous)

Keywords: gambling mindfulness cognitive behavioural therapy
a study for evaluating the efficacy and safety of zonisamide and lamotrigine (lamictal) for subjects with refractory simple partial, complex partial or partial with secondary generalized seizures

Conditions: Epilepsy

Summary: the purpose of this study is to evaluate the efficacy and safety of zonisamide for anti-epilepsy drugs (aeds) treated subjects with refractory simple partial, complex partial or partial with secondary generalized seizures.


Eligibility criteria:
inclusion criteria: * subjects must sign and date the informed consent form * clinical diagnosis as refractory epilepsy exclusion criteria: * progressive neurologic disease * serious psychiatric disease * hemolytic anemia * g6pd (glucose-6-phosphate dehydrogenase) deficiency * acute intermittent porphyrias * subjects who have received study drugs (zonisamide, lamotrigine) in the past * drug or alcohol addiction * renal impairment (serum creatinine ≧ 1.5 mg/dl), or hepatic abnormality (alt or ast \> 2x uln) * stevens-johnson syndrome * progressive exfoliative dermatitis * pregnant, lactating or of childbearing potential female * regularly taking oral contraceptives * hypersensitivity to study drugs * severe cardiac disease (new york heart association functional class iii and iv) * history of malignancy within 5 years * taking valproic acid within 7 days prior to screening * subjects with simple partial seizures without motor component

Keywords: epilepsy seizures