Kornimate/medical-research-clean huggingface dataset:
evaluation of clinical and bone density improvement after implantation of allogenic mesenchymal stem cell from umbilical cord on osteoporosis patients

Conditions: Osteoporosis

Summary: this study will assess the effectiveness of the allogeneic mesenchymal cell from umbilical cord in improving the quality and quantity of spinal density of osteoporosis patients proven by the results of bone mass density (bmd) examination compared to baseline and evaluate improvement of quality of pain with visual analog scale (vas).

currently, preventive and therapeutic strategies for osteoporosis patients are based on calcium and vitamin d supplementation, the use of pharmacological agents that inhibit bone resorption such as bisphosphonates, and sometimes calcitonin. although bisphosphonates have been found to reduce osteoporosis, clinical use for these drugs has been limited because of its potential to produce serious side effects, such as mandibular osteonecrosis and atypical femoral fractures. therefore, new therapeutic strategies for osteoporosis are needed. this study will assess the effectiveness of the allogeneic mesenchymal cell from umbilical cord. patients who have received mesenchymal stem cell therapy (msc) are expected to have positive effects such as reduced pain sensation in the back assessed by visual analog scale (vas), improvement in the range of motion (rom), improving the quality of osteoporosis patients's bone proven by the results of bone mass density (bmd) and improvement in patients' quality of life.

Eligibility criteria:
inclusion criteria: 1. male patients older than 50 yrs old. 2. female patients older than 40 years old. 3. patients enrolled in cipto mangunkusumo hospital with osteoporosis confirmed by bmd test. 4. patients with no history of autoimun disease (sle, addison's disease, chron's disease) and other diseases related to osteoporosis. 5. patients with no history of consuming drug related osteoporosis. 6. no active infection confirmed by hbsag, hiv, cmv, rubella and toxoplasma examination. 7. agree to participate the study by signing informed consent form. exclusion criteria: 1. patients with autoimun diesasde (sle, addison's diesase, chron's disease and other osteoporosis related disease. 2. patients under immunosuppressive, anticoagulant or corticosteroid treatment. 3. paralysis patients after surgical treatment 4. patients under 20 years old 5. declined to participate in the study
long-term outcomes in patients with three-vessel disease

Conditions: Three Vessel Coronary Disease

Summary: the long-term outcome of coronary artery bypass grafting (cabg), percutaneous coronary intervention (pci), and medical therapy (mt) alone for triple-vessel disease (tvd) patients is controversial. the aim of this study is to evaluate the long-term outcome of tvd patients among these three treatment strategies, to find out the most appropriate treatment methods for these patients.

the present study was a retrospective observational study. patients who underwent diagnostic coronary angiography from january 2013 to december 2018 were eligible for this study if they had three-vessel disease, which was defined as more than 50% stenosis in three major epicardial coronary arteries, left anterior descending, left circumﬂex, and right coronary artery. there were no pre-specified exclusion criteria. the choice of pci, cabg, or mt was mainly followed the guidelines and based on clinical and angiographic features, physical condition (comorbidities, malignant tumor, frailty, etc.), complexity, and was discussed by physicians and surgeons, combined with the choice of patients. the pci strategy and stent type were left to the physician's discretion. the primary endpoint were major adverse cardiac and cerebrovascular events (macce), which were a composite of all-cause death, myocardial infarction (mi), repeat revascularization, or stroke. clinical information of in-hospital outcome was obtained by reviewing medical records. follow-up was completed by survey via telephone, letter, or hospital visit. all patients had at least one follow-up visit.

Eligibility criteria:
inclusion criteria: * patients were diagnosed as having three-vessel disease (defined as angiographic stenosis of ≥ 50% in all three main epicardial coronary arteries, with or without left main artery involvement) and age \>18 years. exclusion criteria: * none

Keywords: three-vessel coronary disease percutaneous coronary intervention coronary artery bypass grafting medical therapy clincial outcomes
myocardial protection and clinical outcome in patients undergoing tetralogy of fallot repair : a randomized study of two different cardioplegia technique

Conditions: Myocardial Protection in TOF Repair

Summary: myocardial protection and clinical outcome in patients undergoing tetralogy of fallot repair: a randomized study of two cardioplegic techniques.

del nido cardioplegia has not been used for myocardial protection and clinical outcome in patients undergoing tetralogy of fallot repair, so the investigators hypothesized that a del nido cardioplegia technique may be beneficial in the pediatric patients undergoing tetralogy of fallot repair.

Eligibility criteria:
inclusion criteria: * tetralogy of fallot exclusion criteria: * tof with absent pulmonary valve , tof with pulmonary atresia

Keywords: tetralogy of fallot, cardioplegia
transcranial direct current stimulation in stroke rehabilitation

Conditions: Stroke

Summary: this study investigates if transcranial direct current stimulation (tdcs) is effective in the recovery of postural control in stroke rehabilitation.

the patients were divided in 2 groups by a randomisation procedure. all patients participated for 2 months in the study. group 1 received true tdcs in the first month followed by sham stimulation in the second month. group 2 received sham in the first month and true stimulation in the following month. four stimulations of 20minutes were provided during 4 weeks before before changing stimulation intensity.

Eligibility criteria:
inclusion criteria: 1. patients suffering from the consequences of a stroke in the medial cerebral artery, during the sub-acute phase (4-24 weeks after onset) 2. age between 18-75 years 3. hospitalised in rehabilitation hospital hof ter schelde 4. capable of understanding and giving informed consent exclusion criteria: 1. cerebellum or brainstem lesions 2. recently multiple lesions and older lesions which are manifested clinically. 3. history of severe substance abuse (alcohol, drugs, benzodiazepines) 4. cardiac disease that in the opinion of the clinician precludes participation in the trial (severe dyspnea in rest, severe rhythm disturbances, etc) 5. history of epileptic insults, not caused by the stroke 6. severe organic co morbidity 7. psychiatric disorders or history of psychiatric disorders 8. pace maker / internal defibrillator 9. pregnancy

Keywords: stroke tdcs gait balance loss of postural balance
breakthrough improvement collaborative for ventral mesh rectopexy

Conditions: Rectal Prolapse

Summary: different studies showed large variation between care processes in multiple diseases, this leads to large variation in outcomes. better adherence to evidence-based guidelines for these diseases can reduce this variation and can improve the health outcomes. ventral mesh rectopexy has gained popularity in europe to treat different rectal prolapse syndromes. this procedure has been shown to achieve acceptable anatomic results with low recurrence rates, few complications, and improvements of both constipation and fecal incontinence. however, there is limited data on the care process and outcomes. moreover, there is no insight in the variation between different centers for patients undergoing ventral mesh rectopexy. this study aims to map the variation in care for patients undergoing ventral mesh rectopexy in flemish hospitals and to get an overview about the variation within and between these hospitals. hereby, this will be a repeat of the studies for colorectal cancer, fragility hip fractures, stroke and breast cancer surgery.


Eligibility criteria:
inclusion criteria: * minimum age of 18 years; * elective admission for ventral mesh rectopexy * total rectal prolapse * grade iii internal prolapse with incontinence or obstructed defaecation exclusion criteria: * colpo posterior * patients diagnosed with severe dementia (dsm iv) or severe concomitant disease that may affect very short-term outcome (life expectancy less than 3 months) and hence influence deviations from standard acute care.
acupuncture for postherpetic neuralgia

Conditions: Postherpetic Neuralgia ( PHN )

Summary: the investigators are conducting a clinical study with the following objectives: to evaluate the clinical efficacy of electroacupuncture combined with pregabalin in treating postherpetic neuralgia(phn); to investigate the correlation between serum biomarker levels and pain symptoms;and to determine whether serum biomarkers can serve as prognostic indicators for phn. this study utilizes a randomized controlled trial design with assessor blinding. a total of 207 eligible phn patients were randomly assigned to three groups in a 1:1:1 ratio: the electroacupuncture group, the pharmacotherapy group, and the sham acupuncture group. comparative analyses of pain intensity and serum biomarker concentrations were conducted across these groups. for the assessment of clinical outcomes, the investigators employed the following measures: the numerical rating scale(nrs), the hamilton anxiety scale(hama), the hamilton depression scale(hamd), the 36-item short form health survey(sf-36), serum levels of substance p(sp)and neuropeptide y(npy), and inflammatory markers(il-10,tnf-α). these assessments were performed at baseline and at the end of weeks 1, 2, 3, and 4 of treatment. the investigators anticipate that this clinical trial will enhance our understanding of the therapeutic efficacy and underlying mechanisms of acupuncture in managing phn. it aims to elucidate the relationship between serum biomarkers and the clinical manifestations of phn, as well as to explore their potential prognostic value in disease outcomes.


Eligibility criteria:
inclusion criteria: * meet the diagnostic criteria for phn; * age between 20 and 80 years old; * voluntarily participate in the trial and sign the informed consent form. exclusion criteria: * pregnant or lactating women; * presence of severe liver or kidney dysfunction, malignant tumors, or other serious diseases; * presence of hematologic diseases or coagulation disorders; * presence of mental illness or other cognitive impairments, unable to understand or unwilling to cooperate with the study requirements.

Keywords: acupuncture postherpetic neuralgia serum biomarkers serum substance p neuropeptide y
the effects of music in retrograde intrarenal surgery

Conditions: Retrograde Intrarenal Surgery

Summary: this study aimed to investigate the effect of music listening during the preoperative and postoperative stages in patients undergoing retrograde intrarenal surgery(rirs) on basic life findings, anxiety, pain, and the amount of analgesic used. this is a randomized controlled experimental study. the study was conducted with two groups: the intervention group (n=30) and control group (n=30). the control group received standard care. in contrast, the intervention group, in addition to standard care, was listened to the music by the researchers for 15 minutes one hour before their surgery.


Eligibility criteria:
inclusion criteria: * 18 years of age or above, * had elective rirs, * without hearing/speech impairment, * without mental problems, * without a diagnosis of psychiatric disorders, * without a diagnosis of depression, * had the surgery under general anesthesia, * and volunteered to participate. exclusion criteria: * patients under 18 years of age, * with hearing/speech impairment, * with mental problems, * with a diagnosis of psychiatric disorders, * with a diagnosis of depression, * undergoing the surgery through spinal anesthesia, * not willing to participate in the study
developing a patient oriented discharge summary for stroke inpatients

Conditions: Stroke

Summary: there is a need to improve the discharge process for patients with stroke, which has been reported to be a particularly stressful time for patients. a patient oriented discharge summary (pods) meeting has been shown to be an effective approach for minimizing discharge-related stress and fostering self-management skills in other patients being discharged from rehabilitation into the community. the purpose of this study is to develop and evaluate whether a pods meeting can minimize stress around the discharge process and improve patient satisfaction with this process. there are two main hypotheses regarding the pods program: 1) it will help in-patients with stroke understand key issues related to knowledge required once discharged and 2) it will increase levels of self-efficacy in in-patients with stroke. potential subjects are encouraged to participate if they are a sunnybrook - st. john's rehab admitted in-patient with a stroke diagnosis who are 18 years or older and meet the following criteria: (a) fluent in english; (b) cognitively intact; and (c) have minimal or no aphasia.the participant will be asked to answer some surveys 8-10 days prior to discharge about their knowledge and confidence in managing their stroke. the participant will then be asked to meet with a clinical staff member who will hold a one-hour pods meeting. in the meeting, a discharge plan will be created and given to the patient that covers a number of topics that will be useful following their return to the community. one day following the pods meeting, the participant will be asked to answer the same survey they completed prior to the pods and again 3-5 days following discharge. if the participant is interested they will be asked to undergo a brief interview to get their feedback on the pods program. it is anticipated that about 20 people will participate in the program with all 20 patients completing the surveys with 6 being asked to complete the brief interview. to the best of the investigators knowledge, there is little risk associated with this study. participants may become uncomfortable during the interview while discussing their experiences. by participating in this study, patients will be provided with a chance to gather information and learn problem solving and self-management skills prior to discharge. it is the hope of this project that it can lead to a more effective approach in supporting the transition from the hospital to the community for patients with stroke


Eligibility criteria:
inclusion criteria: * have a stroke diagnosis. * must be minimally aphasic. * physically and cognitively be able to participate in a one-hour pods session and are capable of undergoing the pods meeting, as well as the study assessments in person and by phone (surveys, telephone interview). exclusion criteria: * participants who are unable to communicate fluently in english
pediatric pharmacokinetic (pk) study of exe844 otic suspension in otitis media at the time of tympanostomy tube insertion (omtt)

Conditions: Otitis Media With Effusion in Children; Otitis Media Recurrent

Summary: the purpose of this study is to describe the pharmacokinetics (pk) of exe844 sterile otic suspension, 0.3% following a single bilateral ototopical dose in pediatric subjects, immediately after bilateral tympanostomy tube surgery.


Eligibility criteria:
inclusion criteria: * recurrent acute otitis media (raom) or chronic otitis media with effusion (come) and eligible for bilateral myringotomy and tympanostomy tube insertion; * legally authorized representative (lar) must read and sign the informed consent; * parent or caregiver must agree to complete the required study visits and comply with the requirements of the study; * other protocol-specified inclusion criteria may apply. exclusion criteria: * menarcheal females; * previous otologic or otologic-related surgery within the past 30 days or ongoing complications; * existing perforation of the eardrum; * current acute otitis externa (aoe), malignant otitis externa (moe) or other conditions which could interfere with evaluation of the study drug; * any systemic disease or disorder, complicating factor or structural abnormality that would negatively affect the conduct or outcome of the study; * use of prohibited medications or inadequate washout of any medication including systemic and topical antibiotics, steroids and/or analgesics; * weighs less than 8 kg; * other protocol-specified exclusion criteria may apply.
partially hydrolyzed guar gum (phgg) for amelioration of chronic obstructive pulmonary disease (copd)

Conditions: COPD; Microbial Colonization; Respiratory Tract Disease

Summary: some components of the diet could promote the growth of certain bacterial strains present in the intestine, which are closely associated with benefits for host health. an intestinal commensal parabacteroides goldsteinii (pg) was highlighted to be significantly negatively associated with severity of copd. furthermore, the investigators identify the potential prebiotics (phgg) which may enrich the abundance of p. goldsteinii and increase the probiotic effect of p. goldsteinii. the investigators designed a randomized control study, which enroll adults diagnosed with copd. then the two groups will receive phgg or not. stool samples will be collected. the ameliorative efficacy will be evaluated by questionnaire and lung function test. intestinal microbiota and metabolome will be analyzed and the correlation with lung function indices will be further investigated.

it is well known that some components of the diet could promote the growth of certain bacterial strains present in the intestine, which are closely associated with benefits for host health. in the previous study, the investigators found that an intestinal commensal parabacteroides goldsteinii (pg) was highlighted to be significantly negatively associated with severity of copd. furthermore, the investigators identify the potential prebiotics (phgg) which may enrich the abundance of p. goldsteinii and increase the probiotic effect of p. goldsteinii. however, the effect of phgg supplement on compositional and functional properties of the human microbiota with copd still remains unclear. in this proposal, the investigators designed a randomized control study, which enroll adults diagnosed with copd. the investigators will review their past medical records and related image and lung function test. then the two groups will receive phgg or not. stool samples will be collected. the ameliorative efficacy will be evaluated by questionnaire and lung function test. intestinal microbiota and metabolome will be analyzed and the correlation with lung function indices will be further investigated. in the future, it may be used to investigate and analyze the change of microbiota and metabolome, then develop possible treatment options of copd.

Eligibility criteria:
inclusion criteria: * age of 40-85 years * diagnosis of copd made by pulmonologist * provision of written informed consent exclusion criteria: * severe and unstable comorbidities or active malignancy * copd exacerbation within the 4 weeks prior * cognitive impairment or a psychiatric disorder * pregnancy

Keywords: copd gut microbiota respiratory tract prebiotics
cognitive testing online in parkinson's disease

Conditions: Parkinson Disease

Summary: this is a feasibility and pilot study. though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in parkinson's research. thus a large part of this pilot study will be to demonstrate feasibility and reliability, and use this experience to develop a feasible protocol for ongoing research. the specific short-term objectives are: 1. to establish the feasibility of performing large-scale deep cognitive phenotyping using online cognitive testing. 2. to demonstrate that online neurocognitive testing is valid and reliable in a smaller sample of locally recruited participants tested both in-lab and online.


Eligibility criteria:
inclusion criteria: * diagnosis of parkinson's disease by neurologist or healthy individual with no diagnosis of any neurological illness exclusion criteria: * psychotic spectrum disorders, active uncontrolled depression, advanced dementia (i.e. needing assistance with daily activities such as dressing or bathing), major stroke, major head injury, epilepsy requiring anti-seizure medications
effect of chronic oral hydration in patients with recurrent unexplained syncope

Conditions: Hydration; Loss of Consciousness; Neurocardiogenic Syncope

Summary: beneficial effect of chronic hydration with salt supplementation in patients with recurrent unexplained syncope is not established. we sought to determine if chronic oral rehydration with salt supplementation improved the tolerance and hemodynamic responses of patients with unexplained recurrent syncope.


Eligibility criteria:
inclusion criteria: * syncopal and/or near syncopal episodes at least twice within the prior 3 months exclusion criteria: * neurological disease * structural heart disease * metabolic and psychiatric illness
primary dysmenorrhea severity in athletic vs. non-athletic females

Conditions: Primary Dysmenorrhea

Summary: the aim of the study is to investigate the difference in the severity of primary dysmenorrhea between athletic and non-athletic females.

primary dysmenorrhea is defined as colic pain in the lower abdomen which starts with the onset of menstruation. it is one of the most common gynecological disorders, an important cause of morbidity, and the most common cause of pelvic pain in menstruating girls and women it affects women in any age group. the prevalence varies widely, ranging from 17% to as high as 91%. between 16% to 29% of women with dysmenorrhea have significant impairment in quality of life and the women's well-being. the rate of absenteeism from school, work, or other activities represents up to 15% of women with dysmenorrhea, dysmenorrhea is considered a source of considerable economic losses due to the costs of medications, medical care, and decreased productivity. yoga, pilates, stretching, and other types of exercises have a noticeable effect on decreasing pain, and improving general health, and quality of sleep with different health conditions including primary dysmenorrhea. in addition, exercise and physical activity are used widely and proven to not only decrease pain but also improve quality of life, decrease stress, improve mental health, and in management of depression and stress. for dysmenorrhea the mechanism that explained the effect of exercises on primary dysmenorrhea has been classified according to the intensity of the exercises; moderate -high-intensity exercise was believed to increase the anti-inflammatory cytokines, decrease the overall amount of prostaglandins released because of the decrease of the overall amount of menstrual flow. low-intensity exercise reduces cortisol levels and prostaglandin synthesis

Eligibility criteria:
inclusion criteria: * common inclusion criteria for athletic and non-athletic female. 1. they had a regular menstrual cycle with a menstrual cycle length of 21-30 days. 2. all females were virgins. 3. their ages ranged from 18 to 28 years old. 4. their bmi was ranged from 18.5 -29,9 kg/m2 5. they did not use any pharmacological therapies for controlling pain during menstruation and during the application of the study. inclusion criteria athletic female: 1. they participated in the exercise for the last ≥ 6 months. 2. they did exercises for ≥ 3 days/ week. 3. they practiced (swimming, basketball, volleyball, ballet, gymnastics, judo, wrestling, karate, and boxing). exclusion criteria: 1. history of pelvic pathology or any gynecological disease. 2. they had a history of chronic illness (eg: diabetes). 3. their symptoms of dysmenorrhea became worse over time