Kornimate/medical-research-clean huggingface dataset:
the application of novel identified cd8 regulatory precursors in inducing immune tolerance after allo-hsct

Conditions: Graft-versus-host Disease (GVHD)

Summary: allogeneic hematopoietic stem cell transplantation (allo-hsct) is the most effective treatment for acute leukaemia. the reconstitution of the recipient's immune system with donor-derived hsct cells and the development of immune tolerance are critical to the success of hsct. patients who fail to establish immune tolerance after transplantation develop graft-versus-host disease (gvhd), which is a serious threat to patients' lives and quality of life. utilising single-cell multi-omics sequencing technology, the study's principal investigator elucidated the distribution of immune cell subpopulations in patients who successfully established immune tolerance post-transplantation. this research also identified a novel group of cd8 regulatory precursors (cd8 trps), confirming their critical regulatory role in inducing immune tolerance in post-transplantation patients. this finding suggests that this subpopulation may serve as a novel target for predicting and intervening in gvhd. the successful implementation of this project will establish a new method for early prediction of gvhd and provide a new strategy for clinical intervention of gvhd. the goal of this observational study is to explore the sensitivity and validity of the cd8 trps as a novel biomarker molecule for predicting the development of gvhd through a prospective clinical cohort. the main question it aims to answer is: can the cd8 trps serve as an effective molecular marker for the prediction of gvhd occurrence? can the cd8 trps cell serve as a novel strategy for gvhd intervention?


Eligibility criteria:
inclusion criteria: 1. patients proposed for allogeneic haematopoietic stem cell transplantation; 2. age 18\~60 years old; 3. all enrolled patients need to sign an informed consent. exclusion criteria: 1. patients with type of transplantation as unrelated or cord blood transplantation; 2. lack of patient compliance.

Keywords: allogeneic hematopoietic stem cell transplantation graft-versus-host disease cd8 regulatory precursor immune tolerance immunomodulatory
or pathtrac (tracking intra-operative bacterial transmission)

Conditions: Bacterial Infections

Summary: healthcare-associated infections occur frequently and are associated with patient harm. these infections are becoming more difficult to treat due to antibiotic resistance. it is important that healthcare facilities take the steps necessary to prevent the spread of resistant bacteria between patients.

two patients undergoing sedation in a randomly selected operating room will be evaluated in a serial manner in order to detect transmission of pathogenic bacteria. patient care will not change due to their participation in this study; the patients will undergo sedation and surgery according to usual practice. this study involves taking microbiology cultures from various places in the operating room before and after each procedure. cultures will also be taken from the two patients after they are asleep and from their intravenous tubing. from both patients anesthesiologist, surgeon and their surgical team, crna, and nursing staff will also have cultures obtained. each cultures will be de-identified and given a study id number before transport to the research laboratory for microbiological assay. the patient's medical record will be reviewed for 30 days after surgery to surveil for documentation of a potential hospital acquired infection.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * require peripheral intravenous and/or central venous catheter placement * undergoing gynecology/oncology, colorectal, open vascular, total joint or cardiovascular procedures. exclusion criteria: * less than 18 years of age * does not require peripheral intravenous and/or central venous catheter placement * patient refusal to participate * incarceration
study of the immunogenicity and safety of a challenge dose of hbvaxpro in healthy children vaccinated 10 years ago with 3 doses of hexavac or infanrix hexa

Conditions: Virus Diseases; Hepatitis B

Summary: to evaluate the immune response to hepatitis b virus in children who have been primed with hexavac or infanrix hexa 10 years ago.


Eligibility criteria:
inclusion criteria: * healthy child * child vaccinated with 3 doses of hexavac or 3 doses of infanrix hexa as infant * child vaccinated with the third dose of hexavac or infanrix hexa at least 10 years prior to challenge dose exclusion criteria: * receipt of more than 3 doses of any hepatitis b containing vaccine * history of clinical diagnosis of infection due to hepatitis b * history or current close contact with known carriers of hepatitis b virus * prior known sensitivity or allergy to any component of hbvaxpro * chronic illness / medical condition that could interfere with study conduct or completion * coagulation disorder that would contraindicate intramuscular injection * subject is pregnant * receipt of corticosteroids for more than 14 days in the 30 days prior to study * receipt of immunoglobulins, blood or blood-derived products in the 3 months prior to study * planned participation in another clinical study
role of flexible cystoscopy in laparoscopic stone surgery

Conditions: Kidney Calculi; Ureteral Calculi

Summary: authors want to investigate the usefulness of flexible cystoscopy in performing laparoscopic pyelolithotomies and ureterolithotomies by comparing operative results of a single surgeon's experience.

previous trials to increase stone clearance rates have been recently reached using flexible equipment in laparoscopic surgery, however, it is not clear whether using flexible equipment is really helpful in performing pyelolithotomies and the clearance rates using flexible equipment varies 71% to 100%. therefore, authors plan to investigate the usefulness of flexible cystoscopy in performing laparoscopic pyelolithotomies and ureterolithotomies by comparing operative results of a single surgeon's experience.

Eligibility criteria:
inclusion criteria: * patients with complex renal stones and large or impacted ureter stones * patients who underwent laparoscopic pyelolithotomies with concomitant calyceal stone removal or ureterolithotomy using a flexible cystoscopy or not exclusion criteria: * active infection, uncontrolled bleeding tendency, previous abdominal surgery

Keywords: kidney calculi ureteral calculi cystoscopes laparoscopes
the effects of an intensive lifestyle intervention on employment, earnings, and retirement

Conditions: Diabetes Mellitus, Type 2

Summary: starting in 2001, the look ahead study randomized patients with type 2 diabetes to an intensive lifestyle intervention (ili) focused on weight loss versus a control group receiving diabetes education ("diabetes support and education," or dse). the ili successfully reduced weight, improved diabetes control, and functional status, among other outcomes. in this study, the investigators will compare employment, earnings, and retirement between the ili and the control group during and after the intervention period (2001-2018).

starting in 2001, the look ahead study randomized 5145 patients with type 2 diabetes to an intensive lifestyle intervention (ili) focused on weight loss versus a control group receiving diabetes education ("diabetes support and education," or dse).the look ahead study tested whether participants with type 2 diabetes assigned to an intensive lifestyle intervention (ili) for weight loss exhibited reductions in cardiovascular morbidity and mortality, relative to a control group receiving usual care and diabetes support and education. during the 12-year intervention period, the ili led to persistent reductions in weight, waist circumference, and hemoglobin a1c and improvements in physical fitness, among other clinical benefits. after the conclusion of the intervention in 2012, participants were consented to be linked with administrative data. the investigators attempted to link 3188 consenting participants with social security administration databases. of these, the investigators were able to successfully link 3093 participants. in this study, the investigators will compare employment, earnings, and retirement between the ili and the control group during and after the intervention period (2001-2018). the investigators will determine ili-versus-control differences in employment, earnings, and retirement in each year after randomization, relative to a pre-randomization assessment period. the investigators will also investigate ili-versus-control differences in cumulative years of employment and earnings after randomization which occurred between 2001-2004. the investigators will use multivariate regressions controlling for baseline participant characteristics and clinic site and also survival analyses that estimate whether the time until retirement differs between the ili and control groups.

Eligibility criteria:
(note: age limits above are at time of randomization, which occurred between 2001-2004) inclusion criteria: * look ahead participation: met age requirements and other criteria at time of study enrollment which occurred between 2001-2004 (as noted in look ahead research group (2013)) * consented to administrative data linkages * provided individual identifiers that could be linked with social security administration databases * were successfully linked to social security administration data exclusion criteria: -
acute impact of the impella cp assist device in pts. with cardiogenic shock on the patients hemodynamic

Conditions: Cardiogenic Shock

Summary: prospective, monocentric open-label observational study for the assessment of acute hemodynamic effects following implantation of the impella cp cardiac support device


Eligibility criteria:
inclusion criteria: * cardiogenic shock following acute mi or acute heart failure with * systolic bp \ 30 min or inotropes for support of cardiac output and bp with * signs of left heart failure and pulmonary congestion * and end-organ hypo perfusion with somnolence or cold, pale skin, or oliguria or serum lactate \>2 mmol/l exclusion criteria:

Keywords: impella
first local anaesthesia thoracoscopy for pleural effusion diagnosis.

Conditions: Suspected Malignant Lung Neoplasm; Pleural Effusion; Pleural Effusion, Malignant; Mesothelioma, Malignant

Summary: non randomized study with two groups. the study group includes patients with suspected malignant pleural effusion, in whom the investigation of pleural effusion begins directly with pleural biopsy by local anesthesia thoracoscopy (lat). the control group includes patients who come to the same hospital and are treated with the standard of care (soc) strategies were used. efficacy of lat, sensitivity, hospitalization, time to diagnosis and general safety and comfort of the groups' subjects will be assessed.

diagnostic approach of patients with with unexplained lymphocytic exudate is the main subject of the study. minimally invasive techniques (single entry thoracoscopy with local anesthesia -lat) have been developed for the definitive biopsy of the parietal pleura, with which, in addition to the diagnosis, a therapeutic pleurodesis can be performed at the same time. usually, diagnostic lat is performed only after 3 negative pleural fluid cytological tests have been performed, thus delaying the diagnostic access and treatment of the patient. the aim of this study is to evaluate the conventional diagnostic approach used in daily clinical practice (3 consecutive punctures of pleural effusion with cytological examination and in case of insufficient diagnosis pleural biopsy, either lat or vats depending on the clinical assessment of the patient) with the simplest immediate performance of lat as soon as a pleural effusion suspected of malignancy is detected. thus two subject groups will be compared. the first (lat group) will undergo local anesthesia thoracoscopy as the first line option for the diagnosis of the suspected mpe. the control group will undergo the standard of care recommended guidelines for the diagnosis of mpe.

Eligibility criteria:
inclusion criteria: * undiagnosed pleural effusion with the character of a lymphocytic exudate exclusion criteria: * empyema * transudate pleural effusion. * central airway obstruction by tumor. * existence of extensive adhesions that do not allow the development of iatrogenic pneumothorax and the safe entry of the thoracoscope. * uncontrollable cough. * acute respiratory failure and/or hypercapnia. * performance status: 5

Keywords: malignant pleural effusion local anesthesia thoracoscopy medical thoracoscopy lung cancer mesothelioma lymphocytic exudate
global posture reeducation (gpr) compared to isostretching in chronic low back pain patients

Conditions: Low Back Pain

Summary: the aim of this study was to investigate the changes in posture, flexibility, muscle strength, functional capacity, heart rate(hr), peripheral oxygen saturation, systolic blood pressure, diastolic blood pressure and intensity of pain in chronic low back pain underwent to isostretching and gpr.

it was selected 40 patients, from 40 to 59 years old, with chronic low back pain from cesumar physiotherapy clinic-schoo. these were evaluated before and after treatment regarding posture by sapo computer program; flexibility for lumbar schober testing, sit and reach; muscle strength by dynamometry for trunk extensors and the maximum repetition test in a minute to abdominal and trunk extensors; functional capacity by rolland-morris questionnaire; pain by visual analog scale; heart rate(hr) by polar frequencymetric; peripheral oxygen saturation by finger pulse oximeter; and systolic and diastolic blood pressure with a sphygmomanometer. the sample was divided in two groups (1-gpr with 11 patients, 2-isostretching with 10 patients). all patients were accompanied by an individual treatment program composed by 12 sessions of 45 minutes, twice a week. it was considered statistically significant p values \<0.05 obtained from the student's t test.

Eligibility criteria:
inclusion criteria: * patients with non-specific lbp in its chronic phase (pain lasting more than 12 weeks), from 40 to 60 years old. exclusion criteria: * scheduling conflicts * lack of transportation * disease that compromises their health during the treatment * uncontrolled hypertension * fibromyalgia * history of spinal surgery in the last six months * patients with neurological diseases * individuals who demonstrate inability to understand or physical restraint for the exercises.

Keywords: back pain physical therapy spine rehabilitation exercise
effect of carotid artery stent on evoked cerebral blood oxygenation and neurocognitive functioning

Conditions: Carotid Artery Stenosis

Summary: cerebral hemodynamic compromise from internal carotid artery stenosis may be a cause of vascular cognitive impairment that is amenable to treatment by revascularization. the effect of carotid artery stent on evoked cerebral blood oxygenation and neurocognitive functioning will be evaluated by functional near-infrared spectroscopy. carotid artery stent could benefit cerebral blood oxygenation after stent and improving neurocognitive functioning after 6 months.

patients with high grade internal carotid artery stenosis intended to carotid artery stent are brought to this study. global cognitive function and evoked cerebral blood oxygenation are evaluated before and after stent, followed up at 6 months later. mini-mental state examination(mmse) and montreal cognitive assessment (moca) are used for the global cognitive test. evoked cerebral blood oxygenation is evaluated using functional near-infrared spectroscopy(fnirs) through performing mental task( n-back task, go/no go task, and verbal fluency task ). all the patients from different centers are conducted the test at the only main center by one doctor. the parameter of fnirs and score of cognitive test of each patient are compared before and after stent.

Eligibility criteria:
inclusion criteria: 1. 35-80 years old 2. severe carotid stenosis (mra or cta confirmed stenosis rate of 70% - 99%, nascet standard) 3. asymptomatic or mild stroke (nihss ≤ 3) or tia 4. agree to participate in the clinical trial and sign the informed consent exclusion criteria: 1. severe stenosis or occlusion of vertebrobasilar artery and other intracranial arteries (70% - 99%) 2. left ventricular ejection fraction \< 50% or heart failure 3. other types of dementia have been diagnosed 4. severe depression, mental illness, epilepsy 5. not cooperating with cognitive task evaluation

Keywords: carotid artery stent, functional near-infrared spectroscopy, vascular cognitive impairment,
comparison between low carbohydrate diet and traditionally recommended diabetic diet in the treatment of diabetes mellitus type 2.

Conditions: Diabetes

Summary: the purpose of the clinical trial is to investigate whether low carbohydrate diet is better than the traditional diabetic diet in the treatment of patients with diabetes mellitus type 2, for blood sugar and body weight.


Eligibility criteria:
inclusion criteria: * diabetes mellitus type 2 exclusion criteria: * severe psychiatric disease or difficulties in understanding swedish language.

Keywords: low carbohydrate diet. dietary treatment of diabetes mellitus. diabetes mellitus type 2 and dietary treatment.
replace: can exercise replace inhaled corticosteroid treatment in asthma? a rct

Conditions: Asthma

Summary: to evaluate if physical exercise intervention leads to an improved asthma control as measured by asthma control questionnaire (acq-5) in such a magnitude that inhaled corticosteroid can be reduces in asthmatics.

at least 102 asthmatics will be randomized 2:1 (2 to training group; 1 to control) and undergo 6 months of intervention or usual lifestyle. subjects must have confirmed asthma diagnosis, on a stable treatment with inhaled corticosteroid, symptomatic and untrained. at enrollment and during the study asthma medicine is adjusted based on asthma symptoms evaluated by acq-5. 6 treatment steps are pre-defined, and if well controlled asthma, subjects are down-titrated one step, if uncontrolled, subjects are uptitrated one step.

Eligibility criteria:
inclusion criteria: * asthma (the diagnose of asthma is based on symptoms and at least one positive asthma test the last 5 years (ahr to either mannitol or methacholine, reversibility to beta2-agonist, peak flow variation or positive eucapnic voluntary hyperventilation test)) * acq ≥ 1 and ≤ 2.5 * on a daily dose of ics at a minimum of 400 µg budesonide or equivalent ics for 3 months and with no changes in asthma medicine 4 weeks prior to enrollment * untrained (no participation in vigorous exercise for more than 1 hour per week during the last 2 month) * capable of exercising on bike exclusion criteria: * unable to speak and understand danish * infection within 4 weeks prior to visit 100\* * asthma exacerbation within 4 weeks prior to visit 100\* * hospitalized for an asthma attack during the last 2 months * treatment with immunotherapy within 5 t½ of the treatment drug prior to visit 100 * initiation of allergen immunotherapy within 3 months prior to visit 100 or plan to begin therapy during study period * treatment with peroral prednisolone * respiratory: other chronic pulmonary disease of clinically significance * cardiovascular: unstable ischemic heart disease, myocardial infarction within the last 12 months, symptomatic heart failure (nyha iii-iv or ef \ 155/100) * pregnancy or breastfeeding or planned pregnancy within the next 12 months * other inflammatory or metabolic diseases with the exception of rhinitis, atopy and well-controlled hypothyroidism treated with or without eltroxin * vaccination less than 2 weeks prior to any visit * current or former smokers with \> 20 pack years * subjects, who by investigators determination, will not be able to adhere to study protocol * if patients are excluded due to a recent infection or exacerbation they can undergo re-screening after a total of 4 weeks after end of exacerbation treatment/clearing the infection.

Keywords: asthma exercise asthma treatment inhaled corticosteroid rehabilitation
genomic maps of endometrial tissues of patients with endometriosis and healthy controls

Conditions: Endometriosis; Endometrioma

Summary: endometriosis is a chronic inflammatory disease that affects 10-17% of women in childbearing age, 35-60% of women with chronic pelvic pain and can cause infertility, costing as much as 2.8 billion dollars per year. for this reason, every step taken in diagnosis and treatment is of great importance both materially and spiritually. patients can be diagnosed about 8-9 years after the onset of their complaints due to inadequacy of diagnostic methods in the study, it is decided to look at the basis of the disease, endometrial cells. and aimed to find the difference between the two women who are thought to be no different from each other among our current knowledge but one has endometriosis while other have not.

endometriosis is the appearance of a tissue similar to the endometrium in the ovaries, large intestine, and many other organ walls, except the uterus. the reason is unknown yet. severe periodic pain, infertility, and pain during intercourse, affects approximately 2 million women in turkey on average, 10% of women around the world. endometriosis is a chronic inflammatory disease that affects 10-17% of women in childbearing age, 35-60% of women with chronic pelvic pain and can cause infertility, costing as much as 2.8 billion dollars per year. for this reason, every step taken in diagnosis and treatment is of great importance both materially and spiritually. patients can be diagnosed about 8-9 years after the onset of their complaints due to the inadequacy of diagnostic methods in the study, it is decided to look at the basis of the disease, endometrial cells. and aimed to find the difference between the two women who are thought to be no different from each other among our current knowledge but one has endometriosis while others have not. for this reason, mapping of all genomes with the nanoclonal technique, the most advanced genetic screening method currently available from endometrial samples of patients and healthy women, is to identify the possible copy numbers, translocation, insertion and inversion anomalies, and to name them functionally by proteomic analysis. we believe that the results obtained from our study will guide the diagnostic tests and possible gene therapy in the future.

Eligibility criteria:
inclusion criteria: surgically diagnosed with endometriosis disease * no diagnosıs for malignancy * gave informed consent for application to the study enrolle as patient group females * between 18-45 years old * without any health conditions * applied to the clinic for routine checkups for control group exclusion criteria: * being diagnosed with any kind of malignancy having trouble with endometrial cavity sampling

Keywords: genetic analysis endometriosis nanoclonal copy number