Kornimate/medical-research-clean huggingface dataset:
decompression intervention of variceal rebleeding trial (divert)

Conditions: Esophageal and Gastric Varices; Liver Cirrhosis

Summary: the decompression intervention of variceal rebleeding trial (divert) is a multi-center prospective randomized clinical trial comparing the radiologic procedure of transjugular intrahepatic portal-systemic shunt (tips) with the surgical procedure of distal splenorenal shunt (dsrs) for variceal bleeding in patients with child's class a and b cirrhosis. this is recognized nationally and internationally as the study that will answer the question as to which of these is the best treatment for decompression of varices in patients who have failed endoscopic and pharmacologic therapy.


Eligibility criteria:
inclusion criteria: * variceal bleeding secondary to cirrhosis and portal hypertension * child's class a or b cirrhosis of any etiology * patients who have failed endoscopic therapy (sclerotherapy or banding) of varices; or patients who are not candidates for endoscopic therapy exclusion criteria: * prior shunt procedure * portal vein thrombosis * polycystic liver disease * intractable ascites * prior organ transplant * any medical intractable disease

Keywords: tips dsrs varices variceal bleeding splenorenal shunt transjugular intrahepatic portosystemic shunt cirrhosis portal hypertension liver disease
cerebral oxymetry in traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: vasopressor for current treatment protocols for acute traumatic brain injury can lead to vasoconstriction and thus cerebral hypoperfusion that can be detected with cerebral oxymetry as a drop in sco2.


Eligibility criteria:
inclusion criteria: * patients with acute traumatic severe brain injury requiring neuro intensive care. * the patient admitted must be at least 18 years of age and under 60 years. * intoxication is not an obstacle for inclusion as we believe this will not affect the recording in relation to our problem. exclusion criteria: * traumatic injury in the frontal lobes corresponding to the area where sco2 monitored. * patients in pharmacological studies. * patients with severe heart / lung / blood vessel diseases.
covid-19 and rhino-orbital mucormycosis

Conditions: Mucormycosis

Summary: detect the clinical presentation and outcome of post covid-19 fungal mucormycosis in patients referred to minia university hospital.


Eligibility criteria:
inclusion criteria: 1. patients who had positive pcr test for covid-19. 2. fungal rhino-orbital infection was confirmed. exclusion criteria: 1. suspected patient with covid-19 not confirmed with pcr 2. incomplete data
effectiveness of aerobic exercises on the autistic children

Conditions: Autism Spectrum Disorder

Summary: autism spectrum disorder (asd) is a neurodevelopmental disorder manifesting stereotypic behaviors and problem in communication and social interaction. different physical therapy interventions like aerobics help to improve recurrent behaviors and task performance of autistic children. this study was focused to see the effect of jogging on the stereotypic behaviors and task performance of autistic children. a single blinded randomized study was conducted on 38 autistic children, randomly allocated to two groups, performing jogging and ball exercises. repetitive behavior scale-revised(rbs-r) and jebsen hand function test (jhft) was used for assessment. exercise was performed for 3 weeks and 4 sessions per week.


Eligibility criteria:
inclusion criteria: 1. diagnosed children of autism spectrum disorder (asd) by experts 2. have recognized stereotypic behaviors 3. age 6 to 20 years 4. independent to walk 5. both genders 6. parent and teachers willing to give consent exclusion criteria: 1. unable to understand commands 2. have co-morbidities like schizophrenia or adhd 3. having respiratory or cardiovascular problems 4. severe asd 5. lower limb injury and disability

Keywords: autism spectrum disorder physical therapy stereotypic behaviors asd repetitive behaviors aerobic exercises jogging ball exercises.
effects of statin on hepatocellular carcinoma recurrence after liver transplantation

Conditions: Hepatocellular Carcinoma

Summary: this study aims to investigate whether statin therapy can help prevent recurrence of hepatocellular carcinoma (hcc) in transplant recipients who had liver transplantation for hcc. multiple logistic regression analysis will be performed to evaluate the association between statin therapy and the risk of hcc recurrence after lt.


Eligibility criteria:
inclusion criteria: * patients who received lt at the severance hospital from 2006 to 2016. exclusion criteria: * early postoperative mortality (defined as death within 2 months after lt without signs of tumor recurrence) * patient with distant lymph node metastasis confirmed within 1 month after lt * patients younger than 20 years of age * patients who had lt for cirrhosis without confirmed hcc
catheter ablation of atrial fibrillation in patients with pulmonary hypertension hypertension: a randomised study

Conditions: Atrial Fibrillation; Pulmonary Hypertension

Summary: atrial fibrillation (af) and atrial tachycardia (at), including type i atrial flutter, are frequently observed in patients with pulmonary hypertension (ph). catheter ablation of af / at has been established as an effective treatment option in selected patients. however, little is known about the efficacy and safety of this approach in patients with ph. it has also been shown that considerable proportion of patients with ph after acutely successful catheter ablation suffer from the recurrence of clinical or newly manifested arrhythmia. we propose a prospective study to compare two ablation strategies in a randomized fashion: radiofrequency catheter ablation targeting only the clinical arrhythmia versus more extensive substrate-based catheter ablation. this project will investigate the clinical outcome of patients with pulmonary hypertension and symptomatic atrial fibrillation / tachycardia who will be randomly allocated to selective versus complex radiofrequency catheter ablation of arrhythmogenic substrate.


Eligibility criteria:
inclusion criteria: * pre-capillary ph (pamp ≥25 mmhg; pawp ≤15 mmhg) or combined post- a pre-capillary ph (pamp ≥25 mmhg; pawp \>15 mmhg; dpg ≥7 mmhg and/or pvr \>3 w.u.) of any etiology. exclusion criteria: * complex congenital heart defects (corrected or uncorrected) * isolated post-capillary ph (pamp ≥25 mmhg; pawp \>15 mmhg; dpg \<7 mmhg and/or pvr ≤ 3w.u.) * previous catheter ablation for af / at / afl * previous or scheduled cardiac surgery- * nyha class iv, cardiogenic shock * life expectancy \<1 year * non-compliance

Keywords: atrial fibrillation pulmonary hypertension catheter ablation
multicenter, prospective, non-randomized, single-arm, interventional study for the evaluation of the safety and preformance of the srs device for the treatment of pelvic organ prolapse

Conditions: Anterior Vaginal Wall Prolapse With/Without Apical/Uterine Descent

Summary: a prospective, single arm, multi-center clinical study to evaluate the safety and performance of the srs (lyra medical) vaginal mesh in pop patients

the srs implant is intended for transvaginal surgical treatment of anterior vaginal wall prolapse with or without vaginal apex/uterine prolapses

Eligibility criteria:
inclusion criteria: 1. patient has signed the informed consent form and is willing to participate in the clinical study and data collection. 2. patient age is between 50 and 75 years old 3. pop-q: aa and/or ba is at least -1 exclusion criteria: 1. patient is pregnant or breastfeeding 2. patient is suffering from active infection (on antibiotic therapy) 3. patient is planning vaginal delivery 4. patient had previous vaginal mesh surgery 5. patient is in high risk for surgery (evidence of clinically significant cardiovascular, renal, hepatic, coagulatory or respiratory diseases). 6. any condition that in the judgment of the investigators would interfere with the subject's ability to provide informed consent, comply with study instructions, place the subject at increased risk, or which might confound interpretation of study results. 7. malignancy. 8. known hypersensitivity to peek and/or polypropylene materials. 9. participation in another investigational trial that has not completed the primary endpoint or interferes with study participation. 10. diagnosed with mental or emotional disturbance.
the surgical benefit and pt.tolerability between two different bowel cleansing regimens performed prior to pelvic reconstructive surgery. does one bowel cleansing regimen improve the surgeons visual field significantly better than the other.

Conditions: Pelvic Organ Prolapse

Summary: does mechanical bowel preparation (complete bowel cleansing)help the surgeon with visualization of the operative field during laparoscopic pelvic reconstructive surgery?

patients will be randomized to receive a complete mbp or not prior to their surgical procedure. all patients will use 1 fleets enema the night before surgery and one the morning of surgery to ensure that the rectum is empty of all stool. this will be done since some surgeons use a rectal probe in the rectum to help with manipulation during the procedure. stool in the rectal vault could contaminate the surgical field and lead to an infection. patients will be randomized at their pre-op visit and provided instructions according to the group assignment. on the day of surgery patients will be asked to complete a questionnaire in the pre-op holding area to assess their overnight symptoms including insomnia, weakness, abdominal distention, nausea, thirst and overall tolerability of the bowel preparation assigned. immediately after surgery, the primary surgeon will be asked to complete a visual analog score sheet evaluating the ease of the procedure with regard to retraction of the large and small bowel to help with visualization of the sacral promontory, retraction from posterior cul-de-sac, and maintaining adequate positioning after retraction. all surgeons (attendings, fellows, and residents) will be blinded re: the patients group assignment. each primary surgeon will be asked to assign a final grade to the procedure as easy, medium, or difficult based on overall bowel retraction. at their 2 week follow up visit patients will be asked to report return of bowel function (first bowel movement or flatus) in # of days after surgery and incidents of stool leakage post op.

Eligibility criteria:
inclusion criteria: all patients undergoing the following laparoscopic pelvic reconstructive procedures for pelvic organ prolapse: * laparoscopic sacrocervicopexy * laparoscopic sacrocolpopexy * laparoscopic sacrohysteropexy * laparoscopic uterosacral ligament suspension who understand and are willing to comply with the study requirements, including agreeing to answer the preoperative and postoperative questionnaires exclusion criteria: * previous abdominal or laparoscopic colon surgery (not including transrectal procedures) * history of abdominal malignancy * history of surgical debulking for previous malignancy * non-english speaking * pregnancy * hx of abdomino-pelvic radiation * contraindications to sodium phosphate * contraindications to laparoscopic surgery

Keywords: mechanical bowel prep
melatonin as a novel neuroprotectant in preterm infants- dosage study

Conditions: Premature Birth; Brain Injury

Summary: preterm babies are at risk of brain injury. melatonin, a naturally occurring hormone, may reduce this risk. the unborn baby receives melatonin from the mother but following premature delivery there maybe a period of prolonged melatonin deficiency. this deficiency may be harmful because studies suggest that melatonin is important in protecting the brain and reducing the risk of brain injury after preterm birth. the purpose of this study is to find the ideal dose of melatonin to give to preterm babies. we intend to study a total of 24 babies less than 31 weeks gestation and who are less than 7 days old.

purpose of the study and objectives the overall purpose is to investigate whether melatonin, on achieving adult maternal peak blood levels in preterm infants, will reduce brain injury and white matter disease as defined by specialised magnetic resonance imaging (mri) at term. before testing this hypothesis in a clinical trial, the dose of melatonin required to achieve the desired concentration in preterm infants needs to be determined. this data will be used in the clinical double blinded randomised trial for which a separate application will be made to the ethics committee. the principal research objective in this study is to determine the dose required to achieve physiological melatonin blood levels in the preterm infants similar to that of the mother. secondary objective is to define the pharmacokinetic profile of melatonin in preterm infants. study design and methodology the proposed clinical trial is a single dose, open label, dose escalation pharmacokinetic study in preterm infants less than 31weeks gestation to achieve adult peak blood concentrations of melatonin (200-250 pmol/l). the trial will be a multi centre study based in the neonatal intensive care units in uk. treatment a single intravenous infusion of melatonin will be given to each infant over 6 hours once in the first 7 days of life. the starting dose is 0.1 microgram/kg/hr which will be increased or decreased incrementally in subsequent groups of infants until the desired melatonin concentration is achieved. duration the duration of treatment will be 6 hours only. investigations pharmacokinetic assessment will be performed on the blood and urine samples will be collected 2 hourly at various timepoints. statistical analysis pharmacokinetic assessment will be done using appropriate software.

Eligibility criteria:
inclusion criteria: * infants born less than 31 weeks gestation who are less than 7 days old, after parental consent for participation will be included in the study. exclusion criteria: * those with major congenital malformation, or cystic periventricular leucomalacia (cpvl) or haemorrhagic parenchymal infarcts (hpi) on cranial ultrasonography prior to enrolment will be excluded from the study.

Keywords: premature birth brain injury neuroprotection melatonin pharmacokinetics
assessing manual components of brazilian children and adolescents on hemodialysis

Conditions: Chronic Kidney Disease

Summary: the purpose of this study was to assess the handgrip strength; fine motor skills; and hand sensitivity of brazilian children and adolescents with chronic kidney diseases (ckd). the sample was composed by 42 children and adolescents, 21 on hemodialysis (group a) and the other 21 acted as the control group (group b). the performance of both groups was compared. the outcome measures included jebsen-taylor hand function test, the semmes weinstein monofilaments test and jamar dynamometer.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of ckd with active hemodialysis treatment (only to group a); * ability to understand the tests and questionnaires applied. exclusion criteria: * neuropsychiatric disease associated; and * any medical contraindication against the participation in the study.

Keywords: chronic kidney disease handgrip strength fine motor skills sensitivity
therapy of pragmatic disorders in brain-damaged individuals

Conditions: Brain Injuries, Traumatic; Right Hemispheric Stroke

Summary: this study aims to assess speech therapy's effectiveness in understanding other people's thoughts (implied) using written stories. the main objective is to examine whether the therapy improves understanding of the stories worked on in the sessions. we also explore whether the observed progress is maintained one month after the end of treatment and whether it is generalized to neuropsychological tests, video material, and the participants' daily lives. this therapy will be administered to four individuals with brain lesions, for six weeks, at the rate of two weekly sessions of one hour.


Eligibility criteria:
inclusion criteria: * have been the victim, in adulthood, of a moderate to severe traumatic brain injury (tbi) or a stroke, with at least right frontal lesions (objectified by imaging). the time between the tbi or stroke and participation in this study should be greater than six months. * be of french mother tongue or have an excellent mastery of french. * be between 20 and 65 years old. * be right-handed * present problems in the understanding of non-literal language (irony, indirect requests), objectified by a neuropsychological examination. exclusion criteria: * have a history of psychiatric disorder affecting social cognition (according to dsm-v criteria), and more specifically: autism, schizophrenia, bipolar disorders, major depressive disorders, borderline personality disorders, generalized anxiety disorders, obsessive-compulsive disorders, phobia social and eating disorders (anorexia, bulimia). * have chronic symptoms of an alcohol or drug dependence disorder (according to dsm-v criteria). * have significant uncorrected vision and/or hearing problems. * have aphasia and/or significant reading and comprehension problems. * present significant spatial neglect. * present an impaired capacity for judgment and discernment, objectified by a neuropsychological evaluation. * have been the victim of several tbi or stroke
a smptomatic bacteriuria in pregnancy

Conditions: Bacteriuria in Pregnancy

Summary: asymptomatic bacteriuria (asb) is defined as the presence of at least 105 colony-forming units (cfu)/ml of 1 or 2 bacterial species in clean-voided midstream urine sample from an individual without symptoms of uti

asb is common in women and increases in prevalence with age and/or sexual activity, due to short urethra, pregnancy, easy contamination of urinary tract with fecal flora the pregnant women are two times more commonly affected than age matched non pregnant females. this is due to urinary stasis due to progesterone effect in pregnancy in addition to different morphological and physiological changes occurring during pregnancy the prevalence of asb is about 3 times higher in diabetic women (ranging from 15% to 30%) than in non-diabetic women (less than 10%)

Eligibility criteria:
inclusion criteria: * 1. pregnant females 2. non-symptomatic females. exclusion criteria: * 1. patients taking antibiotics in the last two weeks. 2. symptomatic uti. 3. suspected urinary tract abnormalities. 4. urinary catheterization. 5. renal dialysis.
the effect of breastfeeding support provided via video-conferencing

Conditions: Breastfeeding; Anxiety Disorders; Neonatal Outcomes

Summary: a randomized control trial was made to examine the effects of breastfeeding support given by the video-conferencing method in the early postpartum period on anxiety, breastfeeding self-efficiency, and newborn outcomes.


Eligibility criteria:
inclusion criteria: infants; * born between 37 and 42 weeks * without severe congenital anomalies mothers; * a single live birth * were 18 years of age or over * at least primary school graduate * did not have a disease that prevents breastfeeding * had internet access at home or on the phone * could speak and understand the turkish language. exclusion criteria: * situations that cause separation of mother and baby * hospitalization of the baby in intensive care * inability to answer 3 calls in a video call * they were determined as those who could not be reached during the home visit for the first and second follow
the effect of micro-doses erytropoietin on exercise capacity in male and females

Conditions: Sports Drug Abuse

Summary: recombinant human erythropoietin (rhuepo) regimen enhances maximal oxygen consumption (vo2max), but the effect of micro-doses on maximal and submaximal performance is not clear and detection of micro-doses is difficult with current methods. this study investigated whether micro-doses of rhuepo enhances maximal and endurance performance in males and females.

in a randomized, double-blind, placebo-controlled design, 48 trained adults (24 females, 24 males) receive either recombinant human erythropoietin (rhuepo; epoetin-β, 9 iu/kg, n = 24, (12 females, 12 males)) or placebo (0,9% nacl, n = 24, (12 females, 12 males)) three times per week for four weeks. before the intervention, time trial performance and maximal oxygen uptake will be assessed. three and five days after the last injection, time trial performance and maximal oxygen uptake will be determined to assess the effect of the rhuepo administration. in addition, total hemoglobin mass and intravascular volumes will be determined via the carbon monoxide rebreathing method in duplicate measures.

Eligibility criteria:
inclusion criteria: * relative maximum oxygen uptake (vo2-max) of at least 50 ml o2/min/kg for male participants and 45 ml o2/min/kg for female participants exclusion criteria: * age * insufficient fitness level * blood donation 3 months prior to enrollment * altitude exposure 2 months before enrollment * hypertension

Keywords: erythropoeitin doping
trial of sunitinib for refractory malignant ascites

Conditions: Ascites

Summary: the study is to see whether treatment with sunitinib decreases the accumulation of ascites in patients with refractory malignant ascites.

this is a single arm, non-randomized, phase ii pilot study in patients who have stopped cytotoxic and biologic therapy for their neoplasms and are suffering from malignant ascites that requires drainage for comfort. the study will employ a simon 2-stage optimal design. initially up to 17 patients would be enrolled. if there are no responses among the first 12 patients, the study would be terminated. otherwise the trial would be expanded by 23 to a total of 37 patients. if there are 3 or fewer responses by the end of the trial, then no further investigation would be warranted.

Eligibility criteria:
inclusion criteria: * solid tumor malignancy and failure of at least one biologic or cytotoxic regimen, or the inability to receive standard treatment due to performance status (ps\>2). * ascites based on paracentesis or ct scan within one month prior to enrollment * life expectancy \> 3 months * indwelling paracentesis catheters are permitted, paracentesis is permitted at the investigators discretion * negative urine pregnancy test for females * all subjects must agree to use birth control * all subjects must abstain from eating grapefruit and grapefruit juice. they must tell their physicians about any changes in their medication including over-the-counter and herbal supplements. exclusion criteria: * history of congestive heart failure * creatinine \> 2.0 * pregnant or nursing * alt \> 2.5 times the upper limit of normal * blood pressure \> 160/90 (antihypertensives permitted) * gastrointestinal or intra-abdominal hemorrhage within the last 6 months * history of qtc \> 450 milliseconds * brain metastasis

Keywords: malignant ascites