Kornimate/medical-research-clean huggingface dataset:
clinical study of radical right hemicolectomy versus radical right hemicolectomy combined with indocyanine green fluorescence imaging lymphatic tracer dissection for the treatment of right colon cancer

Conditions: Colon Cancer

Summary: the purpose of this study is to explore the clinical outcomes of indocyanine green fluorescence using in laparoscopic radical right hemicolectomy for right colon cancer（t1-t4a n+ m0）


Eligibility criteria:
inclusion criteria: * 1. age between 18 and 75 years old 2. confirmed adenocarcinoma cancer pathologically 3. location of tumor: from the cecum to the right third of the transverse colon 4. ct showed right colon cancer: t1-t4a n+ m0 5. asa scores i-iii 6. ecog (eastern cooperative oncology group) scale performance status of 0 or 1 7. patient or family member, able to understand the study protocol and willing to participate in the study, providing written informed consent exclusion criteria: * 1. simultaneous or heterochronic multiple primary colon cancer 2. patients with intestinal obstruction, intestinal perforation, intestinal bleeding, etc. requiring emergency surgery 3. unsuitable for laparoscopic surgery (e.g., extensive adhesions due to previous major abdominal surgery; unsuitable for pneumoperitoneum for various reasons, etc.) 4. pregnant or lactating women 5. have a history of serious mental illness 6. history of iodine allergy 7. history of other malignant diseases within the last five years 8. history of prior neoadjuvant chemotherapy or radiation therapy 9. history of unstable angina or myocardial infarction within the last 6 months 10. history of continuous systemic corticosteroid use within one month
identification of patients at risk of ckd after aki

Conditions: Acute Kidney Injury; Kidney Diseases

Summary: the investigators will investigate whether new kidney biomarkers can identify patients who are at risk of chronic kidney disease after an episode of moderate / severe acute kidney injury in icu.

acute kidney injury (aki) is a common complication during critical illness and associated with serious short and long-term complications. participants with aki have an increased risk of developing dysfunction of other organs, including multi-organ failure, a longer stay in hospital and a higher risk of dying. survivors remain at risk of complications, even if kidney function initially recovers. in particular, they are at high risk of developing chronic kidney disease, dialysis-dependent end-stage kidney disease and cardiovascular comorbidities. at present, the tools to identify patients at highest risk of chronic kidney disease (ckd) are very limited. the investigators will recruit participants who had aki whilst in icu and are scheduled to be discharged from hospital. within 3 days of discharge from hospital, blood and urine kidney biomarkers will be measured to explore whether there is a correlation with renal function 3 months later and to identify those at highest risk of ckd. in addition, quality of life at 3 months will be assessed.

Eligibility criteria:
inclusion criteria: critically ill adult patients who had aki stage ii or iii whilst in icu and are scheduled to be discharged from hospital exclusion criteria: 1. known pre-existing end-stage kidney disease or advanced ckd (stage 3b or worse) 2. kidney transplant within the last 12 months 3. known primary renal disease 4. discharge from hospital for end-of-life care 5. transfer to another health care institution for ongoing in-patient care 6. not expected to survive for 3 months 7. pregnancy 8. lack of capacity to give consent 9. receiving regular dialysis at hospital discharge 10. ckd stage 3 or worse at hospital discharge

Keywords: acute kidney injury chronic kidney disease kidney biomarkers
dose-escalation trial of anti-c5ar antibody in healthy subjects

Conditions: Inflammation; Systemic Lupus Erythematosus; Rheumatoid Arthritis; Healthy

Summary: this trial is conducted in europe. the aim of this trial is to develop a complement system targeted monoclonal antibody (mab) to be used in treatment of subjects with chronic autoimmune diseases.


Eligibility criteria:
inclusion criteria: * informed consent obtained before any trial-related activities (trial-related activities are any procedure that would not have been performed during normal management of the subject) * body weight (bw) below or equal to 110.0 kg * body mass index (bmi) 20.0 - 27.0 kg/m\^2, both inclusive * good state of health: evidenced by medical history, physical examination and results of laboratory examinations exclusion criteria: * history of known or suspected cardiovascular diseases including: supine systolic blood pressure (bp) above or equal to 140 mmhg or below 90 mm hg, diastolic bp above oe equal to 90 mm hg or below 40 mm hg, heart rate (hr) in supine position above 100 beats/minute or below 45 beats/minute * hepatic insufficiency: alanine aminotransferase (alt) or aspartate aminotransferase (ast) above upper limit of normal (uln) (retesting is permitted within one week if first test is elevated but below 1.5 fold uln) * renal insufficiency: serum creatinine above uln * positive for humane immunodeficiency virus (hiv) (by test) * positive for hepatitis b (hbv) or hepatitis c (hcv) (by test)
safety and effectiveness of two different formulations of an hiv vaccine in infants born to hiv-infected women

Conditions: HIV Infections; HIV Seronegativity

Summary: the purpose of this study is to test the safety and effectiveness of two different formulations of an hiv vaccine in infants born to hiv-infected women.


Eligibility criteria:
inclusion criteria infants may be eligible for this study if they: * are 1 to 3 days old.

Keywords: hiv preventive vaccine hiv therapeutic vaccine
epidemiological analysis on endometrial cancer in guangdong province of china

Conditions: Endometrial Cancer

Summary: endometrial cancer is one of the most common gynecological cancers, and the incidence increasing in the world. however, there isn't any large sample data of endometrial cancer reported in china. thus endometrial cancer project of guangdong province conduct a large multicentre clinical investigation about endometrial cancer.

endometrial cancer project of guangdong province is mainly conducted by the department of gynecology of the third affiliated hospital of sun yet-sen university, and other 62 major hospitals in guangdong province participate in this project. in this large multicentre clinical investigation, the endometrial cancer database including more than 10,000 cases has been established. further the investigators will demonstrate the epidemiological characteristics, etiology, risk factors, clinical treatment and prognosis of endometrial cancer.

Eligibility criteria:
inclusion criteria: * patients who was diagnosed with endometrial carcinoma from 2000 to 2010 in guangdong province of china; * patients with intact clinical and pathological information exclusion criteria: * not included in the inclusion criteria
a study of atorvastatin for the treatment of high cholesterol in patients at high risk of coronary heart disease (chd)

Conditions: Dyslipidemias

Summary: a study of the long-term (1 year) effectiveness of atorvastatin to keep patients of high cardiovascular risk at the ldl cholesterol goal of \<115 mg/dl


Eligibility criteria:
inclusion criteria: * completion of base study * dyslipidemia and at high risk of chd exclusion criteria: * impaired liver function * gastrointestinal disease that could limit drug absorption
intravenous lidocaine in the prevention of postoperative vomiting in elective tonsil surgery

Conditions: Postoperative Nausea and Vomiting; Pain

Summary: there some evidence regarding the effect of lidocaine for the prevention of nausea and vomiting in adults.

the investigators want to know whether with intravenous lidocaine a adjunct for general anesthesia for children between 2 and 12 years who are undergoing tonsillectomy, with or without adenoids has the same effect.

Eligibility criteria:
inclusion criteria: * children between 2 and 12 years * asa i or ii * programmed for elective tonsillectomy with or without adenoidectomy under general anesthesia exclusion criteria: * obesity, defined as body mass index (bmi) ≥ 95th percentile for age and sex. * use of antiemetic drugs during the 24 hours before surgery. * gastroesophageal reflux. * history of allergy to any of the drugs used in the study. * down syndrome.

Keywords: postoperative nausea vomiting pain surgery
molecular characterization of moraxella catarrhalis from pneumonic children at pediatric assiut university hospital

Conditions: Respiratory Tract Infections

Summary: moraxella catarrhalis is responsible for respiratory tract infection in children and adults with streptococcus pneumonia and haemophilus influenza.moraxella catarrhalis is gram negative diplococci, non-motile and non spore bearing bacteria. until, 1995 it was considered as a non pathogenic respiratory tract flora.this bacteria is an important pathogen and a common cause of both upper and lower respiratory tract infections, pneumonia, sinusitis and conjunctivitis in infants, children and in elderly patients. in adults, m. catarrhalis also causes chronic obstructive pulmonary disease (copd) and pneumonia. however, it is associated with a number of respiratory infections affecting both children and adults, including laryngitis, bronchitis and pneumonia .

this institution is polymicrobial community with other pathogens such as streptococcus pneumoniae and haemophilus influenza (sethi and murphy, 2008). the pathogenicity of m. catarrhalis is mediated by several virulence genes, including the ubiquitous surface protein genes a1 (uspa1) and a2 (uspa2), which encode virulence factors that promote colonization and successful host infections (bernhard s et al.,2012).bacterium was first isolated in 1896, it was considered to be a harmless commensal of the upper respiratory tract for a long period of time. the bacterium rapidly colonizes the nasopharynx soon after birth asymptomatically (blakeway et al., 2017).

Eligibility criteria:
inclusion criteria: * all children with bacterial pneumonia exclusion criteria: * viral pneumonia , tuberculosis and immunocompromised
outcomes of pelvic surgery with and without anti-incontinence procedure in occult stress urinary incontinence patients

Conditions: Pelvic Organ Prolapse; Stress Urinary Incontinence; Other Specified Urinary Incontinence

Summary: 1. to evaluate whether a standardized tension-free vaginal tape-obturator(tvt-o) procedure, when added to a planned improved reconstruction pelvic surgery, improves the rate of urinary stress continence in subjects with occult stress incontinence. 2. observe the immediate and short-term complications, overall urinary tract function, and other aspects of pelvic health between subjects with and without a tvt-o procedure.

the primary aim of this randomized study is evaluate whether a standardized tvt-o procedure, when added to a planned improved reconstruction pelvic surgery for the treatment of pelvic organ prolapse, improves the rate of urinary stress continence in subjects with occult stress incontinence. secondary aims include comparison of immediate and short-term complications, overall urinary tract function, and other aspects of pelvic health between subjects with and without a tvt-o procedure. the value of preoperative urodynamic testing with prolapse reduction and 1 hour pad test will also be compared between subjects with and without a concomitant tvt-o procedure.

Eligibility criteria:
inclusion criteria: * in the absence of medical contraindications for improved pelvic floor reconstruction surgery and the tvt-o surgery * bulge of paries anterior vaginas stage iii-iv * uterine prolapse stage ii-ii * without symptoms of stress urinary incontinence * screening tests of occult stress urinary incontinence(osui) should be positive * ≥55 years old. exclusion criteria: * pregnancy * illegible to follow up after surgery * previous surgery for stress urinary incontinence * unfinished data collection before surgery

Keywords: occult stress incontinence pelvic organ prolapse surgical intervention tvt-o(tension-free vaginal tape-obturator) improved reconstructive pelvic surgery combined surgery two-step approach prophylactic incontinence procedure randomized controlled trial
young-onset colorectal cancer

Conditions: Colon Adenocarcinoma; Colorectal Carcinoma; Rectal Adenocarcinoma

Summary: this study investigates the genetic factors that may influence the risk of developing colorectal cancer at a young age. finding genetic markers for colorectal may help identify patients who are at risk of colorectal cancer. studying individuals and families at high risk of cancer may help identify cancer genes and other persons at risk.

primary objectives: i. to define the clinical phenotype of young-onset versus (vs.) later onset colorectal cancer (crc), including clinicopathologic characteristics, tumor molecular markers, family history, and associated lifestyle/environmental factors. ii. to examine germline genetic alterations in patients with young-onset (diagnosed between age 18 and 50), crc and those of their first-degree relatives, in comparison to those in patients with later-onset (diagnosed at age 51 or older) crc. iii. to determine the frequency of the mutations and pattern of inheritance of the mutations identified above in this patient population. iv. to correlate molecular findings to clinical endpoints of survival and disease recurrence and/or progression in patients with young-onset vs. later-onset crc. v. to compare the treatments received by patients with young-onset vs. later-onset crc and their subsequent survivorship experiences. outline: patients: patients complete questionnaires over 30-50 minutes about work, family history, medical history, health habits, and experience as a cancer survivor (quality of life, well-being, concerns, types of health care, and follow-up care received). active patients, who have undergone treatment at md anderson cancer center within the past year, complete additional questionnaires at enrollment, 6 months, 12 months after treatment completion, and then every years for up to 6 years. also, active patients who are consented to the study more than 5 years from surgery, they may complete the survivorship questionnaire once. patients medical records are also reviewed. family members: participants complete questionnaires over 10-15 minutes. participants also undergo collection of blood or saliva samples once.

Eligibility criteria:
inclusion criteria: * patients: mdacc patients who have adenocarcinoma of the colon or rectum, diagnosed between ages 18 through 50 (young-onset), or diagnosed at age 51 through 80 (later-onset) * patients: patient must have sufficient command of the english language and mental capacity to provide consent * family members: be a parent, sibling or child (first degree blood relative) of a registered mdacc patient meeting eligibility criteria above * family members: have sufficient command of the english language and mental capacity to provide consent * family members: family member must be at least 18 years of age at the time of study registration
expressiona and diagnostic potential of mirnas in nsclc

Conditions: Non Small Cell Lung Cancer

Summary: its to explore the expression pattern, diagnostic and prognostic potentials of mirs (106b-5p, 601 and 760) in serum of nsclc patients

a retrospective observational study on nsclc patients, to determine the serum expression levels if some mirnas in nsclc patients and to find if having proper diagnostic and prognostic values in early disease detection, and/or staging.

Eligibility criteria:
inclusion criteria: * first time and recently diagnosed nsclc patient exclusion criteria: * recurrent nsclc * start of chemotherapy, radiotherapy or surgical intervention * previous treatment * cancer history
the mother (mobile technologies to help enhancing regular physical activity) trial for pregnant women

Conditions: Physical Activity

Summary: obesity among women of childbearing age and excessive weight gain during pregnancy are prevalent and steadily increasing health care issues. regular physical activity is recommended to maintain healthy weight gain for pregnant women, however, a majority of pregnant women are sedentary. the investigators proposed to conduct a pilot study to estimate the potential efficacy of a mobile phone based physical activity intervention in 30 physically inactive pregnant women.


Eligibility criteria:
inclusion criteria: * pregnant, gestational week (10-20 weeks) * pre-pregnancy bmi ≥ 18.5 kg•m2 * physically inactive at work and during leisure time * intent to be physically active * access to a home telephone or a mobile phone * have a personal computer access * ability to communicate (speak and read) in english. exclusion criteria: * known medical or obstetric complication that restricts physical activity * history of eating disorders * current participation in lifestyle modification programs * history of bariatric surgery.

Keywords: cellular phone exercise pregnant women obesity overweight physical activity
comparison of physiological variables during blood donation

Conditions: Hemorrhage

Summary: the investigators have developed a system based on a pulse oximeter, a tablet, and an algorithm running on the tablet that analyzes the pulse oximeter waveform. the algorithm that runs on this system should be able to accurately keep track of blood loss during blood donation. the investigators will compare the algorithm with the blood loss tracked by a device called a flow meter. the algorithm that runs on this system should be able to accurately keep track of stroke volume changes. the investigators will compare the algorithm with the stroke volume changes tracked by a device called a ccnexfin. the algorithm that runs on this system should work whether it's in place for the whole blood donation, or if it's placed after the blood donation has started. the investigators will use two pulse oximeters for the system on each hand and compare one that is used for the whole blood donation versus one that is not used for the whole blood donation.

hypothesis: p-values for testing the hypothesis of no correlation against the alternative that there is a nonzero correlation for each subject will be calculated. the minimum average power correlation, alpha = 0.05, will be used. correlation will be made (cri trend during 550ml blood volume removal) using pre and post blood draw data. specific aims: these data will be submitted to the fda with the following claims: the cri algorithm 1. is intended for use by clinicians and medically qualified personnel to noninvasively display the trend of intravascular volume changes (hemorrhage) 2. is intended for use by clinicians and medically qualified personnel to noninvasively display the trend of stroke volume changes and 3. the cri trend value is not relative to an initial cri reading, instead it is an actual cri trend value that does

Eligibility criteria:
inclusion criteria: * subject is planning on donating blood and is approved by children's hospital colorado's blood donation center * age 18-89 years * previously donated blood (lower likelihood of vasovagal response) exclusion criteria: * pregnant * incarcerated * limited access to or compromised monitoring sites for non-invasive finger sensors
safety & efficacy flograft (micronized human amnion chorion membrane)® in adults with pain due to oa of the knee

Conditions: Osteoarthritis, Knee

Summary: safety \& efficacy of flograft (micronized human amnion chorion membrane)® in adults with pain due to osteoarthritis of the knee.


Eligibility criteria:
inclusion criteria: * able to provide written informed consent to participate in the study. * willing and able to participate in all procedures and follow-up evaluations necessary to complete the study. * subject is 30 years or older. * moderate oa pain (rating of at least 20mm on the vas) assessed at baseline. * moderate to moderately-severe oa pain in the index knee (rating of at least 1.5 on the womac index 3.1 5-point likert pain subscale) assessed at baseline. * must be ambulatory. * no analgesia (including acetaminophen \[paracetamol\]) taken 12 hours prior to an efficacy measure. exclusion criteria: * subject has active infection at the injection site. * subject has rheumatoid arthritis, psoriatic arthritis, or have been diagnosed with any other auto-immune disorders that could be the cause of their knee pain. * bmi greater than 40 kg/m2. * subject has received an intra-articular hyaluronic acid (ha) injection for the treatment of oa of the target knee within 3 months prior to screening. * subject has received an intra-articular amniotic fluid, amniotic membrane or amniotic fluid/membrane combination injection for the treatment of oa of the target knee within 3 months prior to screening. * subject has received a steroid, bone marrow aspirate concentrate (bmac) or platelet rich plasma (prp) injection for the treatment of oa of the target knee within 3 months prior to screening. * subject has had major surgery, arthroplasty or arthroscopy in the target knee within 26 weeks of treatment or plans to have surgery in the target knee within 180 days of treatment. * subject is pregnant or plans to become pregnant within 180 days of treatment. * subject has used an investigational drug, device or biologic within 12 weeks prior to treatment. * subject has any significant medical condition that, in the opinion of the investigator, would interfere with protocol evaluation and participation. * subject is currently taking anticoagulant therapy (excluding plavix or aspirin). * diagnosis of gout in the past 6 month. * major injury to the target knee within the 12 months prior to the screening. * severe hip osteoarthritis ipsilateral to the target knee. * any pain that could interfere with the assessment of the target knee pain (e.g. pain in any other part of the lower extremities, pain radiating to the knee).
identification of predictors of success for lifestyle modifications in overweight pre-diabetic subjects

Conditions: Glucose Intolerance; Obesity

Summary: the primary objective of the study is to identify baseline and early predictors of favorable and unfavorable response to lifestyle intervention. as a secondary objective, the investigators would like to validate our questionnaire or other identified predictors as clinical tools to guide us in selection of the most suitable candidates for lifestyle intervention programs. assuming the same capacity of our questionnaire to predict an absence of weight loss (≥5%) or a loss to follow-up (likelihood ratio for a positive test, lr+ = 9.9), 70 subjects need to be included in this study in order to find a lower limit of the 95% confidence interval above 2.0 for this lr+, which is the limit of an acceptable test. the investigators will enroll participants with pre-diabetes and bmi 27-40 in our program and administer to them at baseline and at 3 months the designed questionnaire, as well as other already well validated questionnaires assessing state of change and readiness to implement diet or exercise modifications.


Eligibility criteria:
inclusion criteria: * bmi between 27-40 kg/m2 * impaired glucose tolerance, confirmed by an oral glucose tolerance test (ogtt = fasting glucose lower than 7.0 mmol/l and glucose 2 hours post 75g of glucose between 7.8-11.0 mmol/l), or impaired fasting glucose (6.1-6.9 mmol/l) * 18 years old or more * being able to read and give an informed consent exclusion criteria: * conditions that affects weight or glucose metabolism