Kornimate/medical-research-clean huggingface dataset:
promotion and application of a new three-level etiological diagnosis strategy for fever clinics in respiratory infectious diseases

Conditions: Respiratory Infectious Diseases

Summary: relying on fever clinics, this project evaluates the clinical diagnostic efficiency of the three-level pathogen diagnostic system, monitors changes in respiratory pathogens, and realizes real-time monitoring and early warning of acute respiratory infectious diseases in shanghai.

this study mainly includes subjects who enter the outpatient and emergency departments, fever clinics, and wards of each center from december 2022. according to the clinical manifestations and epidemiological information of the patients, different step-by-step detection methods will be adopted to optimize the allocation of clinical resources and improve the quality of life. this study aims to improve pathogen diagnosis efficiency and achieve regional respiratory early warning.

Eligibility criteria:
inclusion criteria: 1. acute onset within one week; 2. 18-70 years old; 3. present with pneumonia (present with pulmonary signs or radiological changes) or influenza-like illness (including the following symptoms: sudden onset of fever (\>38 ℃),plus cough and/or other respiratory symptoms such as shortness of breath plus one or more systemic symptoms (fatigue, headache ect.)) exclusion criteria: 1. unable to collect nasal/nasopharyngeal swab/wash/aspirate due to structural disorder or mental problem. 2. patients with psycological problem or unconsciousness who cannot tell the disease history and cooperate with medical examinations;
genetics of cvd risk factors in samoans

Conditions: Cardiovascular Diseases; Heart Diseases; Obesity; Atherosclerosis

Summary: to evaluate the role of known genes involved in lipid metabolism on serum lipid and apolipoprotein levels in samoans residing in american and western samoa, who were exposed to the biobehavioral changes of modernization.

background: modernizing samoans are characterized by high levels of certain cardiovascular disease (cvd) risk factors such as extreme adiposity and high prevalences of obesity and hypertension. however, lipid levels in samoans such as total cholesterol and high density lipoprotein (hdl) cholesterol are not consistent with their obesity and not always consistent with ecological measures of modernization. design narrative: the cross-sectional study used serum lipid and lipoprotein and dietary data collected in 1994 and 1995 in american and western samoa to compare the american and western samoans. quantitative determinations were made of lipid and apolipoprotein levels differences between the two groups. estimates were made of the effects of dietary intake, body size, and smoking on lipid and apolipoproteins. cross-sectional analyses were performed on genetic factors influencing lipid and lipoprotein levels. statistical analyses were conducted to test hypotheses about gene-environment interactions and gene-gene interactions in polynesians from american samoa and western samoa. diet, physical activity and body size vary with exposure to the influences of economic modernization and the adoption of non-traditional behaviors. although adiposity and its central distribution, insulin, blood pressure and dietary cholesterol increase from western samoa to american samoa, saturated fat intakes due to coconuts and cigarette smoking are greater in western samoa. thus, modernization does not produce simple unilineal changes in risk factors. the investigators examined very specific hypotheses, based on the cross-sectional data collected in 1994 and 1995, about the influence of genes on lipids, about genetic interactions on lipids and about concrete environmental and specific gene interactions on lipid outcomes. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
a randomized, placebo-controlled trial to examine the efficacy of oral donepezil in subjects with mci

Conditions: Alzheimer's Disease

Summary: to purpose of this study is to estimate the effect of donepezil on neuropsychological testing (npt) and brain proton magnetic resonance spectroscopy.


Eligibility criteria:
inclusion criteria: * healthy males or females ages 55-90 inclusive (healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and heart rate measurement, 12-lead ecg and clinical laboratory tests) * body mass index (bmi) between 18 to 34 kg/m2, inclusive; and a total body weight * subjects with mild cognitive impairment (mci) must have a reliable informant who has an average of 10 hours per week or more contact with the subject. * memory complaints and memory difficulties, which are verified by an informant * mini-mental status exam (mmse) score of 24-30 exclusion criteria: * subjects with known hypersensitivity to donepezil hydrochloride or to piperidine derivatives * insulin-requiring diabetes or uncontrolled diabetes mellitus * subjects with a current diagnosis of depression or other psychiatric illnesses
best possible medication history at usb

Conditions: Best Possible Medication History

Summary: this pilot project investigates the use of a structured medication history (best possible medication history, bpmh) in patients (primarily admitted at the emergency department of university hospital basel) after transfer to a medical ward. unintentional medication discrepancies are analyzed comparing outpatient and inpatient medication therapy.


Eligibility criteria:
inclusion criteria: * admission to emergency department of university hospital basel and transfer to medical ward exclusion criteria: * medication history taken at emergency department of university hospital basel not present

Keywords: adverse drug events (ades) medication accuracy medication discrepancy
bone markers in pediatric if

Conditions: Intestinal Failure; Osteoporosis; Metabolic Bone Disease

Summary: poor bone health is a well-recognized but poorly understood complication in children with intestinal failure (if) who are dependent on parenteral nutrition (pn). previously, we showed that children with if have decreased bone turnover markers. it is currently unknown if optimization of parenteral nutrition is related to improved bone turnover markers. serum concentrations of bone markers (osteocalcin, bone-specific alkaline phosphatase and c-telopeptide) will be measured in 30 if patients treated at a multidisciplinary intestinal rehabilitation and home pn program at the hospital for sick children and compared to bone markers in 30 age- and sex-matched healthy controls.

it is currently unknown if optimization of pn mixtures leads to a measurable change in bone turnover markers. our hypothesis is that bone turnover markers of children with if whose pn has been optimized will not differ from those of healthy control subjects, with a positive effect on bone mineral density. our aims are: * to measure bone turnover markers in children with if on long-term pn and compare them with age- and sex-matched healthy children who never received pn * to evaluate if changes in bone turnover markers are related to changes in bone mineral density measured by dual energy x-ray absorptiometry (dxa) * to identify if- and pn-related factors associated with bone health to be able to answer these aims, bone markers in children with if will be compared to bone markers in healthy controls, age- and sex-matched.

Eligibility criteria:
inclusion criteria are as follows: in order to be eligible to participate in this study, a patient must meet all of the following criteria at time of inclusion: 1. consent provided 2. age \< 18 years 3. suffering from if needing pn providing at least 25% of calories for ≥6 weeks 4. medically stable with no acute changes in condition requiring hospitalization, or other intervention at home (for at least 3 months). for healthy controls the inclusion criteria are as follows: 1. consent provided 2. age \< 18 years. a patient who meets any of the following criteria will be excluded from participation in this study: 1. on pn for \< 6 weeks 2. suffering from an acute clinical event, for example gastroenteritis, colds and flu 3. suffering from sepsis on antibiotics 4. on medication known to affect bone metabolism, for example steroids 5. having a history of fracture within the last 12 months. for healthy controls, the exclusion criteria are as follows: 1. any condition known to affect bone health (chronic disease, bone disease, history of malignancy, radiotherapy, steroid use, mental or physical disability) 2. a positive history of fractures within the past 2 years 3. poor growth (weight- and height-for-age below - 2 or above + 2 standard deviation score using the who growth charts).
physical exercise for treatment of depression and anxiety - rct

Conditions: Depression; Anxiety

Summary: in a 12 week randomly controlled open trial 102 participants with symptoms of depression and/or anxiety will be exposed to either aerobic high intensity training (hit) or relaxation therapy. cognitive functions, biomarkers, psychiatric symptom scales and physical status will be collected at baseline, after 12 weeks and after a year. depression and anxiety will be measured twice during the intervention period.


Eligibility criteria:
inclusion criteria: * score ≥12 on madrs or score ≥16 on bai * inhabitant i örebro county, sweden * bmi ≥18 kg/m\^2 exclusion criteria: * diagnosis of chronic psychotic disease or ongoing psychotic episode. * ongoing manic state of bipolar disorder * severe somatic disease or condition where high intensity exercise is contraindicated * difficulty with reading, hearing or understanding the swedish language

Keywords: post traumatic stress disorder attention deficit hyperactivity disorder exercise bipolar disorder cognitive functions biomarkers fatty acids cytokines neurotrophins accelerometer microbiota metabolomics lipidomics
small intestinal function in patients with cystic fibrosis

Conditions: Cystic Fibrosis; Gastrointestinal Motility

Summary: in patients with cystic fibrosis (cf) epithelial transport of chloride and sodium is disrupted in several organs such as airways, sweat glands, pancreas and intestines. gastrointestinal symptoms are frequent but little is known about intestinal motility and function. earlier studies using lactulose/hydrogen breath tests have found altered intestinal transit time. the method has several sources of errors and results have been questioned. this study is using a new, non invasive method to study intestinal motility patterns and transit times, magnetic tracking system - 1 (mts-1). the aim is to compare patterns of contractility and transit times in the stomach and small intestine in adult cf- patients with healthy controls. methods mts-1 is performed without radiation and is associated with minimal discomfort for subjects. a small magnetic pill is ingest and detected by a matrix of sensors. position and orientation of the magnet are defined by five coordinates (position: x, y, z, angle: φ, θ). frequencies of slow waves as well as number and power of phase iii contractions can be identified. colorectal transit times are determined with a plain abdominal x-ray. the subjects are asked to ingest a capsule containing 10 radiopaque markers on six consecutive days up to examination. the total number of markers in the entire colorectum is counted. total transit time, as well as segmental is calculated. subjects 15 adult patients (\> 18 years) with cf, homozygote for the mutation δf508, are studied. they are all pancreas insufficient (fecal elastase \< 100 µg/g), with no previous intestinal resection or lung transplantation. none of them have diabetes. patients are all in well-regulated pancreatic enzyme replacement therapy (pert), thriving and with stabile weight over the last half year. they have had no treatment with antibiotics in the last 14 days up to the examination. the hypothesis is that patterns of contractility and transit times are the same for cf-patients in well -regulated pert as for healthy controls.


Eligibility criteria:
inclusion criteria: * cystic fibrosis, severe mutations * pancreatic insufficiency(fecal elastase \< 100 µg/g) * thriving, stabile weight over the last half year * no treatment with antibiotics in the last 14 days up to the examination exclusion criteria: * intestinal resection * lung transplantation * diabetes
effect of urocortins in patients with heart failure

Conditions: Heart Failure; Endothelium

Summary: despite modern advances in treatment, heart failure continues to carry a poor prognosis with high morbidity and mortality rates. hence, there remains a major interest in the development of novel therapeutic agents for this debilitating condition. urocortins have recently shot into limelight with their potential role in the pathophysiology and treatment of heart failure. recent studies by the investigators group (rec no: 09/s1103/41) have confirmed that urocortin 2 and 3 are potent arterial vasodilators, the effects of which are reproducible and well tolerated in healthy male volunteers. previous studies using heart failure models in animals1-7, as well studies in heart failure patients (urocortin 2), suggest that there is great scope for urocortins as novel biomarkers and as potential therapeutic agents in heart failure. with this in mind, the investigators wish to study the local vasomotor effects of these peptides in greater detail in patients with heart failure.


Eligibility criteria:
inclusion criteria: patients with heart failure: 1. patients with stable heart failure (nyha class ii-iv) on maximum tolerated doses of an ace inhibitor and beta-blocker for at least 3 months. 2. baseline echocardiographic parameters (echo performed within last 12 months) at recruitment: ejection fraction (ef) \ 5.5cm and fractional shortening \<20% 3. age 18-80 years (inclusive) at recruitment healthy volunteers: * age and sex-matched healthy volunteers exclusion criteria: 1. lack of informed consent 2. age \ 80 years 3. current involvement in a clinical trial 4. systolic blood pressure \>190 mmhg or \<90 mmhg, untreated malignant arrhythmias 5. haemodynamically significant valvular heart disease 6. severe or significant co-morbidity including bleeding diathesis, renal or hepatic failure 7. history of anaemia 8. recent infective/inflammatory condition 9. recent blood donation (prior 3 months) 10. women of child bearing potential

Keywords: urocortin 2 urocortin 3 forearm venous occlusion plethysmography heart failure endothelium substance p
effectiveness of triple therapy with palonosetron for pon prophylaxis

Conditions: Postoperative Nausea and Vomiting

Summary: postoperative nausea and vomiting (ponv) is a displeasing experience that distresses surgical patients during the first 24 hours after a surgical procedure. the incidence of postoperative nausea occurs in about 50%, the incidence of postoperative vomiting is about 30%, and in high-risk patients, the ponv rate could be as high as 80%. therefore, the study design of this single arm, non-randomized, pilot study assessed the efficacy and safety profile of a triple therapy combination with palonosetron, dexamethasone and promethazine to prevent ponv in patients undergoing craniotomies under general anesthesia.

at induction of anesthesia, a triple therapy of palonosetron 0.075 mg iv, dexamethasone 10 mg iv and promethazine 25 mg iv was given as ponv prophylaxis. after surgery, subjects were transferred to the surgical intensive care unit (sicu) or post anesthesia care unit as clinically indicated. ondansetron 4 mg iv was administered as primary rescue medication to subjects with ponv symptoms. ponv was assessed and collected every 24 hours for 5 days via direct interview and/or medical charts review.

Eligibility criteria:
inclusion criteria: * adult patients, 18 to 85 years of age, of any race or gender. with an american society of anesthesiologist (asa) physical status of i to iii who are scheduled to undergo neurological surgery requiring opening of the cranium and dura matter under general anesthesia, at ohio state university medical center and who consent in writing to participating in this study. * post operative hospitalization expected to last at least 72 hours. * subjects whose surgery is expected to require at least 1 hours of general anesthesia * subjects who have a negative serum or urine pregnancy test within 1 day of surgery or who have been surgically sterilized or are postmenopausal. exclusion criteria: * subjects who are prisoners, pregnant, mentally ill, under the age of 18 or over the age of 85, asa classification of v, alcohol or drug abusers. * subjects with known hypersensitivity to any 5-ht3 antagonist, to any agent that is part of the anesthesia regimen, or to other medications to be administered under this protocol. * subjects who are breastfeeding. * subjects who have had retching/vomiting or moderate to severe nausea in the 24 hours prior to anesthesia or suffer chronic nausea and/or vomiting * subjects who have been treated with any drug or other treatment with anti-emetic efficacy within the last 24 hours prior to the start of treatment. * subjects who have participated in a clinical trial of an investigational drug within 30 days prior to surgery. * subjects who are participating in any other clinical study

Keywords: palonosetron craniotomy nausea vomiting
genome study in constitutional thinness

Conditions: Thinness; Leanness

Summary: constitutional thinness (ct) is a recently defined entity as a differential diagnosis of anorexia nervosa (an), considered to be the most frequent cause of low body mass index (bmi) in young women. ct subjects present no an psychiatric traits, preserved menses, no biological signs of undernutrition and balanced energy metabolism despite a body mass index (bmi) \<17 kg / m². ct familial aggregation, low body mass without a hormonal explanation, and specific appetite regulation profile suggest a specific genetic profile in these subjects. objective: a family linkage study in order to identify genes involved in the constitutional thinness phenotype by using genome wide scan (gwas) techniques studied population: fifty families including at least one well phenotyped ct index case (grade 2 or 3 of thinness according who classification). blood or saliva is sampled for dna extraction. perspectives: revealing eventual abnormalities could lead to a more precise diagnosis of constitutional thinness and new hypothesis in understanding extreme bodyweight mechanisms.


Eligibility criteria:
inclusion criteria: * for all subjects: * age \> 18 yrs * affiliation to health insurance * member of a family including at least 2 ct members and overall 3 evaluable members over 2 generations * written and signed consent * for ct subjects : * grade 2 or 3 of thinness according who classification * women, bmi \< 17 kg/m² at 20-30 yrs or \< 19 for older subjects * men, bmi \< 18 kg/m² at 20-30 yrs or \< 20 for older subjects * absence of dsm criteria for anorexia nervosa * young women : normal menses and fat mass percentage 15 % ; absence of dsm criteria for anorexia nervosa * men : normal testosterone level * for subjects without ct : * women, bmi \> 19 kg/m² * men, bmi \> 20 kg/m² exclusion criteria: * ct subjects: * smoking \> 5 cigarettes / day * history of emaciating pathologies * intense physical activity \> 7 hours / week * for all subjects : * refuse of written consent

Keywords: constitutional thinness linkage study genome wide scan (gwas)
prospective randomized study comparing eptfe versus dacron graft for anterior sector venous drainage in right lobe living donor liver transplantation

Conditions: Patency and Infection Rates Due to Usage of PTFE vs.Dacron Grafts

Summary: living donor liver transplantation (ldlt) using the right lobe (rl) has created a significant increase in graft supply worldwide. however, it is a technically demanding procedure particularly because of the unique functional anatomic characteristics of hepatic venous drainage \[1\].

in the absence of an adequate drainage of the anterior sector (as) veins, the consequent venous congestion in the rl graft may result in impaired graft regeneration, immediate liver dysfunction, and graft loss even in a liver graft of adequate size \[2\]. to overcome this problem, lee et al. \[3\] introduced the concept of modified rl graft in which the branches of the middle hepatic vein (mhv) was drained using interposition vascular grafts. although, the issue of when and how the mhv branches should be drained has been controversial since then, reconstruction of segment 5 and 8 veins using an interposition graft has become a standard procedure during rl ldlt. the vascular graft of choice in this procedure has been cryopreserved homologous vein graft, which provides excellent patency with low infection risk. however, such grafts are often unavailable, particularly in programs where deceased donors are scarce and surgeons must rely on synthetic grafts such as expanded polytetrafluoroethylene (eptfe) and polyethylene terephthalate (dacron®). since we have developed an "intent-to-drain" policy in our ldlt program, we have been using dacron grafts exclusively \[4\]. although, complications such as early graft thrombosis, graft infection, and hollow viscous migration remain as major concerns, the safety and efficacy of both eptfe and dacron grafts in ldlt has been proven \[5, 6\]. however, to date, none of the previous studies have specifically compared these two different prosthetic materials, addressing graft patency and complication rates in patients undergoing ldlt. the aim of our study is to compare as venous outflow reconstruction using eptfe vs. dacron grafts for their patency and infection rates and outcomes with respect to graft and patient survival in rl ldlt.

Eligibility criteria:
inclusion criteria: 1. primary adult living donor liver transplantation 2. right lobe graft with anterior sector venous outflow reconstruction - exclusion criteria: 1. right lobe graft without anterior sector venous outflow reconstruction 2. liver re-transplantation -
elastography interest in the management of thyroid nodules

Conditions: Thyroid Nodules

Summary: define an ultrasound/elastography benignity criteria in strategy management of a patient population carries one or more thyroid nodules.


Eligibility criteria:
inclusion criteria: * patient aged over 18 years old * patient affiliated to social security or similarly regime * patients referred for fine needle aspiration or surgery with one or more thyroid nodules exclusion criteria: * patients with too much thyroid nodules or topography too imprecise to allow unambiguous correlation between echo/elastography data and histology/cytology data * patients withan echography/elastography indications cons * pregnant women and lactating mothers * adult unable to express their consent * ward of court or under guardianship * person under legal protection * person deprived of freedom by judicial or administrative decision * person hospitalized without their consent

Keywords: echography elastography thyroid nodules needles punction thyroid surgery patients with thyroids nodules