Kornimate/medical-research-clean huggingface dataset:
prevalence and factors associated with sleep disorders in inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases; Crohn Disease; Ulcerative Colitis; Sleep Disorder

Summary: inflammatory bowel diseases (ibd) including crohn's disease (cd) and ulcerative colitis (uc), are an inflammatory disease that can affect the entire digestive tract from the mouth to the anus for cd and the entire colon and rectum for uc. they mainly affect adolescents and young adults. these pathologies evolve in relapses interspersed with phases of remission. sometimes associated with extraintestinal manifestations (joint, dermatological, ophthalmological or biliary systems), chronic inflammation of the digestive tract and the resulting symptoms (abdominal pain, diarrhea, rectal syndrome, etc.) lead to a significant alteration in the quality of life of patients in all spheres of activity (professional, sexual, social). sleep is a basic neurophysiological state, the normal total duration of which in humans is between six and ten hours per day. it is an essential element of the circadian rhythm in humans, influencing certain cellular functions and in particular the synthesis of cytokines and pro-inflammatory molecules. sleep disturbances and disruption of the circadian rhythm lead to metabolic and immunological dysfunctions, which may be involved in chronic inflammatory conditions through changes in the immune response. in the field of ibd, many studies suggest poor sleep quality in patients with ibd. while there seems to be a link between sleep disorders and impaired quality of life with a socio-professional impact in these patients, the links between ibd activity, its treatment and sleep disorders are poorly studied, with discordant results in previous studies. in order to enrich our knowledge on this topic, the investigators wish to study the prevalence and risk factors associated with sleep disorders in ibd patients in order to improve patients' quality of life


Eligibility criteria:
inclusion criteria: * adult patients with crohn's disease (cd) or ulcerative colitis (uc) presenting for consultation or hospitalization in gastroenterology unit exclusion criteria: * patients with an identified sleep pathology

Keywords: inflammatory bowel diseases crohn's disease ulcerative colitis sleep disorders
new imaging procedure for the localisation of insulinoma

Conditions: Endogenous Hyperinsulinaemic Hypoglycaemia

Summary: insulinoma: insulinoma are rare, small insulin secreting neuroendocrine tumors. the only curative approach is the surgical excision. the preoperative detection remains a challenge. a non-invasive, highly sensitive tool in localizing the insulinomas would be appreciated in the preoperative work-up of these patients. to this aim glucagon-like peptide-1 receptor (glp-1r) imaging (single photon emission computer tomography co-registered with a ct; spect/ct) could be a convenient tool. the possibly more sensitive approach of targeting glp-1r using positron emission tomography (pet/ct) methodology has not been investigated in patients so far.


Eligibility criteria:
inclusion criteria: * biochemically proven endogenous hyperinsulinaemic hypoglycaemia in the fasting state with neuroglycopenic symptoms or autologous islet cell transplantation in the forearm * conventional imaging (ct,mri or eus) not older than 2 months * signed written consent * age above 18 years exclusion criteria: * kidney failure (creatinine \> 140micromol/l) * known allergies against exendin-4 (byetta or bydureon) * pregnancy * breastfeeding * medication with byetta or bydureon * evidence for malignancy (extrapancreatic tumor manifestations)

Keywords: localisation of insulinoma beta-cell imaging exendin-4 68ga-dota-exendin-4 pet/ct 111in-dota-exendin-4 spect/ct
glycemic responses to majia pomelos in type 2 diabetic patients

Conditions: Diabetes

Summary: food intake has a great influence on blood glucose of patients with diabetes. this study was designed to determine the glycemic index (gi) of a particular pomelo named majia pomelo and its effects on postprandial glucose (ppg) excursions in both healthy subjects and patients with type 2 diabetes (t2dm).

the purpose of this study was to evaluate the gi and effects on glucose excursion of majia pomelo in both healthy and diabetic subjects. the results may help diabetic subjects and their health care providers in developing a diet that is both medically and culturally appropriate.

Eligibility criteria:
inclusion criteria: * in the diabetic and diabetic 2 groups, it required that their diabetes was controlled (hba1c ≤ 8%) on diet with or without metformin. exclusion criteria: * morbid obesity (bmi \> 40 kg/m2) * pre diabetes * pregnancy * presence of gastroenterological disorders * alimentary tract surgery * a history of gastroenteritis in the prior six months * any alcohol intake * smoking * taking any medications (except metformin) * poorly controlled diabetes (hba1c \> 8%) * presence of chronic diseases (such as bronchial asthma or rheumatoid arthritis) or acute illness (such as upper respiratory tract or urinary tract infection)

Keywords: glycemic index glycemic response diabetes pomelo
smart life smart living intercontinental - medical students' cohort

Conditions: Mental Health Issue; Student Burnout

Summary: the question of the well-being, quality of life and mental health of care students is unanimously considered to be a central issue among young adults. according to the french ministry of higher education and research, there will be 194,752 care students in france in 2021-2022. the quality of life and well-being of health students can be affected at several levels. the first is mental health. in france, the mental health of these students has deteriorated considerably in recent years. according to a 2017 survey of 21,768 french medical students, 66% of them had an anxiety disorder and 27% a depressive syndrome. in addition, a number of risk factors have been identified for the mental health of health students. the aim of the study is to carry out a longitudinal evaluation of the mental health status of care students during their university studies in france through anxiety, depression and perceived stress.


Eligibility criteria:
inclusion criteria: * students who are regularly enrolled in healthcare courses at a french university exclusion criteria: * age under 18
cortical plasticity in spastic diplegia after selective dorsal rhizotomy

Conditions: Spastic Diplegia

Summary: the purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after selective dorsal rhizotomy.

to establish the structural changes in the corticopyramidal tract using diffusion tractography imaging (dti) due to selective dorsal rhizotomy and compare the resting state functional connectivity(rsfcmri) temporal latency differences of spastic diplegics for selective dorsal rhizotomy.

Eligibility criteria:
inclusion criteria: * children diagnosis with spastic diplegia and having selective dorsal rhizotomy surgery exclusion criteria: * no selective dorsal rhizotomy surgery

Keywords: cerebral palsy
propolis effects in patients with chronic kidney disease

Conditions: Chronic Kidney Diseases

Summary: the aim of this study is to determine the impact of propolis on proteinuria reduction and protection of the glomerular filtration rate in chronic renal failure patients.


Eligibility criteria:
inclusion criteria: * older than 18 years; * less than 90 years; * glomerular filtration rate between 25 and 70 ml / min; * proteinuria in the urine 24 hours more than 300 mg or protein / creatinina in isolated urine greater than 0.3g / g or microalbuminuria (albumin / creatinine ratio) between 30-300 mg / g. exclusion criteria: * pregnants; * neoplasia carrier; * renal transplant patients; * patients who refuse to participate in the study. * glomerulopathy on immunosuppression

Keywords: proteinuria propolis chronic kidney disease
post-operative hernias after radical cystectomy

Conditions: Evisceration; Traumatic; Hernia

Summary: post-operative hernias after cystectomy are frequent (our review of the literature with meta-analysis found an incidence of evisceration at 5%, median eventrations at 8% and peristomal hernias at 14%). these represent a non-negligible and partially morbidity. avoidable, subject to proper assessment of personal and surgical risk factors


Eligibility criteria:
inclusion criteria: * having undergone a cystectomy (for cancer or not), * with or without reconstruction, between 01/01/2010 and 12/31/2020 exclusion criteria: - refusing to participate

Keywords: median hernia parastomal hernia cystectomy
evaluation of the ability of fesoterodine to increase urethral pressure in stress urinary incontinence patients

Conditions: Stress Urinary Incontinence

Summary: the hypothesis under evaluation is that fesotorodine may provide clinical benefit in the treatment of the condition of stress urinary incontinence


Eligibility criteria:
inclusion criteria: * female, 18 - 65 years * sui symptoms for longer than 3 months * subjects must be non-pregnant and not breastfeeding exclusion criteria: * disease or medical condition affecting the bladder or urinary tract (other tan stress urinary incontinence) * subjects taking medication with effects on the bladder or urinary tract * subejcts with medical conditions which could be adversely affected by administration of fesoterodine - gastrointestinal tract disease, glaucoma, hepatic impairment

Keywords: phase 2 stress urinary incontinence fesoterodine
metabolic and endocrine status in women with prior preterm birth

Conditions: Polycystic Ovary Syndrome; Preterm Birth; Diabetes Mellitus

Summary: the prevalence of preterm birth is rising in most western countries. the causes of preterm birth is not fully understood and seem to be multifactorial. the endocrine and metabolic aspects are scarcely investigated.the main purpose of this study is to test the hypothesis that endocrine and metabolic factors associate to preterm births.


Eligibility criteria:
inclusion criteria: * one or more preterm birth in the given period of time * having namsos hospital as their local hospital during pregnancy exclusion criteria: * moved from the region of mid- norway at the time of the study * lack of communication skills in norwegian or english * ongoing pregnancy * ongoing breastfeeding

Keywords: preterm birth preterm labour polycystic ovary syndrome pcos diabetes mellitus hyperandrogenism hirsutism ovarian cysts anti muller hormone hypertension
radiographic evaluation in alveolar preservation using platelet-rich fibrin. randomized controlled trial

Conditions: Alveolar Bone Resorption; Preserving the Alveolar Ridge

Summary: this randomized controlled trial is designed to assess the use of platelet-rich fibrin (prf), a biomaterial derived from a participant's own blood, in alveolar ridge preservation following premolar extraction for orthodontic purposes. participants aged 17 to 38 years requiring premolar extractions will be randomly assigned to receive either prf application or natural healing without intervention. cone beam computed tomography (cbct) will be used to evaluate changes in alveolar bone dimensions and density at 30 and 120 days post-extraction. measurements will be taken at standardized vertical levels (1 mm, 3 mm, and 5 mm apical to the crest) to analyze bone height, width, and density over time.

this study is a randomized controlled clinical trial designed to investigate the application of platelet-rich fibrin (prf) in post-extraction sites following orthodontically indicated premolar removals. prf is prepared from autologous blood and applied to extraction sockets in the experimental group, while the control group undergoes standard physiological healing. cone beam computed tomography (cbct) will be used to obtain quantitative data on alveolar bone structure at baseline, 30 days, and 120 days post-extraction. the study will assess changes in bone height, horizontal ridge width at defined depths, and bone tissue density using standardized imaging protocols. this design allows for objective comparison between treated and untreated sites.

Eligibility criteria:
inclusion criteria: * healthy individuals with no systemic diseases. * age range: 17 to 38 years old. * orthodontic indication for premolar extraction (two maxillary or two mandibular premolars). * candidates for orthognathic surgery or extraction of impacted/retained teeth (e.g., third molars with a relationship to critical anatomical structures). * clinical justification for cbct imaging instead of standard radiographic -techniques. exclusion criteria: * patients with systemic diseases that may alter periodontal therapy outcomes. * platelet count below 200,000 mm³. * immunosuppressed patients. * pregnant or lactating women. * smokers. * patients taking medications that interfere with healing (e.g., bisphosphonates, corticosteroids, anticoagulants).

Keywords: bone regeneration tooth socket oral surgery platelet-rich fibrin cbct
normal saline versus heparin intermittent flushing for the prevention of occlusion in port-a-cath

Conditions: Port-a-cath Occlusion; Normal Saline; Heparin Lock

Summary: purpose: an evidence implementation of a randomized controlled trial for whether there is the difference in intermittent flushing 0.9% normal saline and heparin? design: a single-blind randomized controlled trial method: this study is based on the 5a (ask, acquire, appraise, apply, audit) of evidence health care step, and design randomized controlled trial for evidence implementation. we will include inpatients over 20 years-old adults in new taipei city tucheng hospital, taiwan, who need administration medicine by port-a-catcher. the sample size is 192 according to g-power software. random allocation software has using for block randomization, would assign to group a: flushing with 0.9% normal saline 10ml, group b: flushing with 0.9% normal saline 20ml, and group c: flushing with heparin 100 usp/ml. spss 20.0 software for statistical analysis, mean or standard deviation, one- way anova would use.


Eligibility criteria:
inclusion criteria: non-pediatric inpatients over 20 years of age with pac placed for any disease and who need medication during hospitalization. exclusion criteria: history of pac obstruction, continuous high volume drip via pac, taking anticoagulant or antiplatelet agents, abnormal blood coagulation, pregnancy or contraceptive use, specified flushing solution by case
catheter ablation of longstanding persistent atrial fibrillation

Conditions: Atrial Fibrillation

Summary: this randomized prospective study compared three ablation strategies in patients with longstanding persistent atrial fibrillation (lpeaf). it also explored the best procedural endpoint from among the following: circumferential pulmonary vein isolation (pvi)+left atrial (la) linear lesions (roof line, mitral isthmus)+complex fractionated atrial electrogram (cfae) ablation, pvi+la linear lesions +cavotricuspid isthmus (cti) ablation +cfae ablation, and pvi+cfae ablation.

patients were randomized into three ablation groups: group a (n=100): pvi+la linear ablation (roof line and mitral isthmus) +cfae ablation; group b (n=100): pvi+linear ablation (roof line, mitral isthmus, and cti) +cfae ablation; group c (n=100), pvi+cfae ablation.

Eligibility criteria:
inclusion criteria: * patients with longstanding persistent atrial fibrillation (lasting for\>1 year) * exhibited refractoriness to at least one antiarrhythmic drug * left atrial diameter \<=60mm exclusion criteria: * patients with uncontrolled congestive heart failure * having significant valvular disease and/or prosthetic heart valve(s) * with myocardial infarction or stroke within 6 months of screening * with significant congenital heart disease;ejection fraction was \<40% measured by echocardiography * allergic to contrast media * contraindication to warfarin or heparin * severe pulmonary disease e.g. restrictive pulmonary disease * chronic obstructive disease (copd) * left atrial (la) thrombus measured by pre-procedure transesophageal echocardiography * having any contraindication to right or left sided heart catheterization * poor general health * life expectancy less than 6 months

Keywords: ablation linear lesions
plasma b-type natriuretic peptide concentrations in preterm infants < 28 weeks

Conditions: Infant, Premature; Ductus Arteriosus, Patent; Natriuretic Peptide Brain

Summary: the aim of the study was to evaluate bnp in preterm infants \< 28 weeks on the second day of life, when it is still unknown, if a patent ductus arteriosus is hemodynamic significant or not. we hypothesized that high plasma bnp concentrations on day 2 are associated with the need of pda intervention in the further course.

from the study infants blood samples (0.1ml) were collected in k-edta microtubes within 24 to 48 hours of age through umbilical artery catheter aspiration or routine venous puncture. the samples were spun at 7000 rpm for 3 minutes. platelet-free plasma was stored at -20°c until bnp analysis of all collected samples was carried out. the bnp assay was performed using a fully automated immunoassay system advia method for the centaur system (bayer diagnostic division). in preterm infants who were treated with indomethacin or surgical ligation we collected additional blood samples 2-4 hours before intervention and 24 hours after the completion of the ductus treatment.

Eligibility criteria:
inclusion criteria: * written parental informed consent * preterm infant \< 28 weeks of gestation * admitted to our nicu within 48 hours after birth exclusion criteria: * no written parental informed consent, * congenital heart disease, * death

Keywords: preterm infants < 28 weeks b-type natriuretic peptide prediction ductus intervention
physical fitness in celiac disease patients - the effect of a gluten free diet

Conditions: Celiac Disease in Children

Summary: evaluating the effect of celiac disease (cd) and gluten free diet (gfd) on physical fitness parameters among cd subjects. the cd subjects will be compared to healthy controls.

this is a prospective observational cohort study. the study would take place at meir medical center (kfar-saba, israel), a secondary-level academic hospital. the investigators will enroll 50 newly diagnosed cd subjects. the diagnosis will be in accordance with the european society for gastroenterology hepatology and nutrition guidelines for the diagnosis of cd from 2012 (6). the investigators will also enroll 50 control subjects. the control subjects are children visiting the pediatric gastroenterology clinic. before enrollment the investigators will rule out chronic conditions involving the gastrointestinal tract including cd. all subjects will be enrolled after providing an informed consent and signing the consent form. the investigators will obtain the following measurements and evaluations at and 6 months after enrollment: 1. anthropometric measurements: height, weight, body mass index (bmi) and total body fat will be evaluated using a tanita scale. the z-score for each parameter will be recorded. 2. a godin leisure-time exercise questionnaire (7) will be filled by the subjects and their parents 3. evaluation of physical fitness by the eurofit fitness testing (8). this series of physical fitness tests was developed to evaluate speed, stamina and strength in school-aged children. 1. flamingo balance test 2. seat and reach test 3. standing broad jump test 4. handgrip test 5. sit-ups test 6. bent arm hang test 7. twenty meter endurance shuttle run test 8. wingate anaerobic fitness test 4. bone speed of sound test will be performed by a bone sonometer - a non-invasive ultrasound based measurement of bone density. 5. cd subjects will be evaluated for adherence to gfd via questioning by a pediatric gastroenterologist and a clinical dietitian and by serum tissue transglutaminase immunoglobulin a (iga) level (or serum deamidated gliadin peptide immunoglobulin g level in iga deficient subjects). this is part of the normal follow-up of cd patients.

Eligibility criteria:
inclusion criteria: 1. children aged 4-18y visiting the pediatric gastroenterology clinic 2. signing a consent form exclusion criteria: 1. family history of cardiovascular diseases or sudden death before age 50y 2. chronic condition limiting the ability to perform the physical fitness tests (e.g. juvenile idiopathic arthritis) 3. failure to complete the measurements and evaluations by 2 months from the date of the visit at the clinic

Keywords: gluten free diet fitness pediatric
treatment and complications of musculoskeletal tumors

Conditions: Musculoskeletal Diseases or Conditions

Summary: patients being treated for musculoskeletal tumors were included in the study. their records were reviewed retrospectively and data was gathered regarding types of surgeries and post-operative complications including recurrence or development of secondary tumors if any.


Eligibility criteria:
inclusion criteria: * patients undergoing treatment for musculoskeletal tumors exclusion criteria: * patients who did not undergo any surgical intervention
quality study of anesthetic technique on breast cancer surgery

Conditions: Postoperative Pain; Quality of Recovery; Satisfaction

Summary: previous studies have shown that paravertebral block (pvb) has the potential to reduce pain and side effects after breast surgery when used in addition to general anesthesia or sedation.the investigators would like to further discern the impact of ga or pvb on the postoperative qor, pain and satisfaction.


Eligibility criteria:
inclusion criteria: * patient has a physical status between asa i and iii * female * 18 - 70 years of age * patients able to read a newspaper in chinese. * elective unilateral wide excision/simple mastectomy and slnb/alnd * patient has signed an informed consent * without contraindication of ga or pvb * body mass index (bmi) less than 24 kg/m2 exclusion criteria: * asa \> iii * inability to provide informed consent * bleeding disorders * contraindications to nonsteroidal anti-inflammatory drugs (nsaids) * allergy to amide-type local anesthetics or nsaids * infection at the thoracic paravertebral injection site * pregnancy or breast-feeding * severe spine or chest wall deformity * body mass index equal to or more than 24 kg/m2 * patients with major psychosis or drug and alcohol abuse * patients with a history of significant neurological, psychiatric, neuromuscular, cardiovascular, pulmonary, renal or hepatic disease * patients with significant visual impairment or other physical disability that precludes complete cooperation