Kornimate/medical-research-clean huggingface dataset:
case series study to detect sars-cov-2 in semen of covid-19 patients

Conditions: SARS-CoV-2

Summary: a descriptive, clinical series, single-centre, national, biomedical study to determine the presence of sars-cov-2 in sperm samples from positive pcr patients for covid-19 and to evaluate the presence of the virus in the sperm samples after a negative pcr for covid-19

in late december 2019, a new coronavirus strain emerged in china causing coronavirus disease 2019 (covid19). since then, covid19 has become a global pandemic outbreak being declared a "public health emergency of international concern" by the international health regulations emergency committee of the who on january 30, 2020. the pandemic concerns to public worldwide but also to couples aiming to conceive through natural means or undergoing assisted reproductive technologies (art). different organizations including the american society of reproductive medicine have recommended a precautionary approach. therefore, new cycles for infertility patients as well as non-medically urgent gamete preservation treatments, such as social egg freezing, have been suspended in many countries. the decision to resume the in vitro fertilization (ivf) treatment make us to question if virus could be in gametes affecting couples and reproductive outcomes. the presence of the virus in sperm have contradictory results. the present study aims to describe if there could be presence of virus in sperm samples of patients with positive diagnosis for covid-19, and if so, if the virus turns negative on the sperm after the patient recovers and have a negative result for covid-19. also it aims to assess the presence of the virus in the seminal plasma and discern if it possible to disseminate it by sexual transmission. an interim analysis is expected to be carried out once the 50% of the expected recruitment is achieved.

Eligibility criteria:
inclusion criteria: * patients whose written informed consent approved by the ethics committee (ec) has been obtained, after having been duly informed of the nature of the study and voluntarily accepted to participate after being fully aware of the potential risks, benefits and any discomfort involved. * male age: 18 - 65 years, both included. * covid-19 positive result by pcr (including symptomatic and asymptomatic subjects). exclusion criteria: * patients with severe symptoms or any other medical condition that is unstable or which, according to medical criteria, may put at risk the patient's safety and his compliance in the study * known medical history of azoospermia or anejaculation

Keywords: sars-cov-2 covid-19 severe acute respiratory syndrome coronavirus 2 semen
conservative treatment for atlantoaxial dislocation patients without neurological deficit

Conditions: Atlantoaxial Dislocation

Summary: the goal of this observational study was to learn about the long-term clinical efficacy of conservative treatment in atlantoaxial dislocation patients without neurological deficit. the main question it aims to answer is: is surgical intervention always necessary in atlantoaxial dislocation patients without nerve deficit? patients who refuse surgical intervention will continue to be treated conservatively. clinical outcomes will be summarized over five years of follow-up


Eligibility criteria:
inclusion criteria: * the patients meet the diagnostic criteria for atlantoaxial dislocation, that is, the adi exceeds the normal range: it is over 3 mm in adults and over 5 mm in children. * the patients have no clinical manifestations of the nervous system, including occipital neuralgia, manifestations of cranial nerve impairment (such as dysphagia, dysarthria, nystagmus, etc.) and manifestations of spinal cord impairment (such as unsteadiness in holding objects, unsteady gait, decreased limb muscle strength, etc.). * after fully understanding their own conditions as well as the advantages, disadvantages and risks of both conservative treatment and surgical treatment, the patients can choose the initial treatment method on their own. if they choose conservative treatment, they will be included in the conservative treatment. if they choose surgical treatment, they will be included in the surgical intervention group. exclusion criteria: * patients who have undergone surgeries in the cranio-cervical junction previously. * patients with infections or tumors in the cranio-cervical junction. * patients with fresh fractures in the cranio-cervical junction. * patients with clinical manifestations of nerve deficit. * patients with severe diseases in other spinal regions such as the thoracic and lumbar spine that affect their clinical symptoms; patients with motor neuron diseases like amyotrophic lateral sclerosis and other severe neurological diseases. * patients who have participated in other clinical trials within the recent three months. * patients with mental disorders whose cognitive impairments (or those of their legal guardians) prevent them from giving full informed consent. * patients who refuse to participate in this study.
chicago urban resiliency building (curb)

Conditions: Major Depression

Summary: the purpose of the study is to determine whether a culturally tailored, low-cost, primary care/internet based depression prevention intervention (curb) is superior to wait-list control for african american and hispanic youth in terms of depression-related outcomes. it is hypothesized that compared to teens in the wait-list control condition, teens in the curb program will exhibit lower levels of depressed mood and/or more rapid changes in mood during the follow-up time.

additional aims and hypotheses are provided here: aim 2: to determine whether or not participants in the curb primary care/internet based depression prevention intervention will have a significantly lower cumulative incidence of any depressive episode at 3 months compared to adolescents in the usual care wait-list group. hypothesis 2: compared to youth in the wait-list control condition, youth in the curb program will have a lower incidence of depressive episodes at 6 month follow-up. aim 3: to determine whether curb is sustainable in primary care from the perspective of health care professionals and primary care physicians in urban primary care settings. hypothesis 3: we hypothesize that providers will rate the intervention (by component) feasibility, acceptability, willingness to perform intervention and sustainability \> 7 on a 1-10 scale (1, not feasible, 10 very feasible).

Eligibility criteria:
inclusion criteria: adolescents: * male and female african american and latino/a youth ages 13 -17 years old. * adolescents with depressed mood (\> 2 weeks duration) will be eligible unless they have already exceeded the diagnostic threshold for major depressive disorder or have a comorbid condition as defined in the exclusion criteria. parents: * parent of eligible adolescents primary care physicians (pcps): * physician at one of the four mile square health centers. health care professionals: * employee at one of the four mile square health centers. exclusion criteria: * adolescents undergoing active treatment for depression \[active treatment for depression is defined as receiving anti-depressant medication or counseling within one year of remission of symptoms from the most recent episode\] * adolescents meeting probable diagnostic criteria for the following: major depression, substance and alcohol abuse, panic attacks, generalized anxiety disorder, eating disorders, history of treatment for bi-polar disorder or schizophrenia or who are at elevated risk for suicide (often have suicidal thoughts or recent intent)

Keywords: adolescent randomized trial internet depressive disorder primary care prevention
iterative endotracheal tube cuff pressure monitoring

Conditions: Spine Disease

Summary: studies in the medical literature underline the importance of monitoring the pressure of the balloon and the relationship with the incidence cited on the pain and discomfort related to the gesture of the upper airways. there are no formal recommendations in the literature, the french society of anesthesia and resuscitation (sfar) recommends monitoring the pressure intraoperatively except after intubation. it would be interesting to see and thus make an inventory of the practices, to reiterate the importance of monitoring throughout the gesture and at the change of position to avoid either micro-inhalation linked to under pressure of the balloon or overpressure which causes a potential risk of tracheal injury.


Eligibility criteria:
inclusion criteria: * elderly patient ≥ 18 years old * patient who has a scheduled spine intervention in the prone position from january 1, 2023 to april 30, 2023 * intubated patient with endotracheal tube under mechanical ventilation * sedation and curarization * asa 1, 2 and 3 * duration of surgery \> 1 hour * subject not objecting to the reuse of their data for the purposes of this research. exclusion criteria: * subject who expressed their opposition to participating in the study * asa 4, difficult intubation and emergency * lung pathologies (asthma, copd, tracheomalacia) * severe heart failure * septic, cardiogenic or volume shock * morbid obesity (bmi \>40)

Keywords: spine disease spine surgery intubation cuff pressure endotracheal intubation upper airways
engaging families to improve the care of patients with hypospadias

Conditions: Hypospadias

Summary: reconstructive surgery is advocated for most children with hypospadias, a condition in which the pee hold is not in the correct place on the penis, to prevent potentially serious cosmetic and functional problems. parents faced with a decision about hypospadias repair encounter an irreversible choice with potentially lifelong consequences. recent studies have identified decisional conflict (dc) and decisional regret (dr) as a significant problem for parents. several recent guidelines on complex urologic topics suggest that shared decision-making (sdm) is the optimal approach. a pilot test of a decision aid website by parents potentially facing this decision will be conducted to measure pre- and post-outcomes, in order to develop a fuller understanding of how urologists can effectively provide parents with optimal decision support. parents will answer questions via phone up to four time points, twice before (t1 and t2) and twice after seeing a urologist for a hypospadias referral (t3 and t4). if the urologist diagnoses hypospadias but recommends no surgery, the final data collection point will be three months after the urology visit. if the urologist recommends repair surgery, the final data collection point will be six months after surgery.


Eligibility criteria:
inclusion criteria: * parents 18 years of age and older of sons with hypospadias, or a tentative hypospadias diagnosis, and/or referral to a urologist for hypospadias * patient newborn up to age 5 years * parent able to consent and do interview in english * parent access to a reliable internet and smart phone, tablet, or computer to view the website * child/patient scheduled to see a urologist, but must not have yet seen the urologist at the time of enrollment * parent aware that there is an issue with child's pee hole * parent planning to attend urology appointment exclusion criteria: * as target enrollment groups are filled, parents may be excluded in order to achieve a balanced sample, e.g. exclusion of mothers/female caregivers.

Keywords: hypospadias shared decision making decisional regret decision aid
percutaneous needle technique is comparable to open z-plasty surgery for unilateral tendon achilles lengthening in children with cerebral palsy

Conditions: Cerebral Palsy; Equinus Foot Deformity in Children With Cerebral Palsy; Gait Analysis in Neurological Disorders

Summary: this study aims to compare the outcomes of two surgical techniques for achilles tendon lengthening in ambulatory children with cerebral palsy (cp): the percutaneous needle technique and the traditional open z-lengthening technique. the primary objective is to evaluate the effectiveness of these techniques in improving ankle dorsiflexion and gait function one year postoperatively. secondary objectives include assessing postoperative complications, re-rupture rates, and patient satisfaction. the study is designed as a retrospective, matched-pair cohort study, utilizing data from clinical records, 3d gait analysis (3dga), and structured telephone interviews.


Eligibility criteria:
inclusion criteria: * ambulatory children with spastic cerebral palsy (unilateral or bilateral). * indication for achilles tendon lengthening confirmed by 3d gait analysis. * underwent unilateral either percutaneous needle technique or open z-lengthening between 2015 and 2022. * availability of preoperative and one-year postoperative 3d gait analysis data. * informed consent obtained. exclusion criteria: * multilevel surgical interventions. * previous foot surgeries that alter foot anatomy. * non-compliance with rehabilitation protocols or orthotic use. * botulinum toxin-a injections in the triceps surae within six months pre- or post-surgery. * incomplete or inadequate 3d gait analysis data. * lack of informed consent.

Keywords: cerebral palsy tendon achilles open surgery z-plasty lengthening needle lengthening technique
prevalence of hpv infection using self-sampling

Conditions: HPV - Anogenital Human Papilloma Virus Infection

Summary: background: currently prevalence of hpv infections for high risk strains among young women in switzerland is unknown. in addition, since 2008 a vaccination program to prevent these infections has been implemented in a number of cantons, but its actual population impact is currently unknown. for now, hpv screening in switzerland is mainly performed by gynecologists or during gynecological consultation at hospital. this method is certainly effective, but expensive; population coverage of screening is still insufficient. a whole segment of the target population does not participate in this screening especially young people of foreign origin, for various reasons: economic cost, no gynecological, and for other reasons. several studies raise the effectiveness and efficiency of self-sampling to increase coverage of screening, and the rate of participation of non-participants. through this study, the investigators evaluate effectiveness of this vaccination on the prevalence of hpv infections using hpv prevalence kit and assess evolution of infection and clearance of hpv virus during 5 years in a population of young unvaccinated and vaccinated women. method: during the study, each participants will perform a vaginal swab sampling by auto to research hpv. these samples will be sent to a laboratory where hpv typing is done by pcr using the anyplex ™ ii technology. the study will focus on a sample of 400 young women. participants must complete a questionnaire containing demographic questions and their hpv immunization status. vaccination coverage expected in this population is about 50%. depending on the state of vaccination, two different groups will be vaccinated vs unvaccinated (200 women per group). the cases of hpv infection are then calculated for each group and compared as a function of the status of vaccination. statistical tests will be applied mcnemar's test for comparison between the hpv prevalence rates between the 2 groups. expected results: this study will allow us to confirm the possibility of using self-sampling as a method of screening and monitoring of hpv infections in the general population, it will also enable us to document the effectiveness of hpv vaccination by comparing prevalence rate of hpv infections among a group of young girls vaccinated and not vaccine and assess evolution of infection and clearance of hpv virus.


Eligibility criteria:
inclusion criteria: * • eligible women aged between 18-31 years attending of haute ecole de santé - genève and faculty of medicine at the university of geneva. * understands study procedures and accepts voluntarily to participate by signing the informed consent form (icf) exclusion criteria: * • history of hysterectomy or treatment on the cervix during the last 12 months
eye diseases "treated" with interoperable medical informatics

Conditions: Intravitreal Injections

Summary: the overarching goal of eyematics is to promote an interoperable, sustainable infrastructure for the integration and sharing of data from clinical research to improve personalized medicine in ophthalmology. to achieve this, eyematics bundles the expertise and preliminary work of the four consortia of the medical informatics initiative (mii) and the ophthalmological centers of excellence in germany. the perspective and concerns of patients will be strongly incorporated into the project work through close cooperation with patient representatives and the inclusion of patient feedback on quality of life and treatment success. eyematics aims to improve the understanding of the therapeutic success of eye diseases that are usually treated with intravitreal surgical medication (ivom). to this end, an exemplary analysis platform for "real" clinical data will be provided and a dashboard for data visualization and analysis will be developed as a web application. the dashboard is to be introduced at all participating hospital sites for research purposes.


Eligibility criteria:
inclusion criteria: * ops code: "5-156.9 injection of drugs into the posterior segment of the eye"

Keywords: artificial intelligence core dataset intraviteal injection medical informatics data exchange
ultrasound guided intermediate cervical plexus block for congenital muscular torticollis

Conditions: Congenital Muscular Torticollis

Summary: congenital muscular torticollis (cmt) is a postural deformity of head and neck detected at birth or shortly after birth, primarily resulting from unilateral shortening of sternocleidomastoid muscle (scm). surgery could be chosen for the treatment for some children, which is accompanied by moderate pain and discomfort. the investigators focused the effectiveness of intermediates cervical plexus block because the dermatome of sensory of cervical plexus block is correlated to that of torticollis. so the effect of analgesia could decrease the use of analgesics.


Eligibility criteria:
inclusion criteria: * asa i-ii * undergoing general anesthesia for unipolar sternocleidomastoid release in patient with congenital muscular torticollis exclusion criteria: * coagulation disorder * kidney or liver disease * allergy to local anesthetics
dipyridamole assessment for flare reduction in systemic lupus erythematosus (sle)

Conditions: Systemic Lupus Erythematosus

Summary: dipyridamole, a medication extensively used in combination with aspirin for stroke prevention, is a promising new treatment for lupus. dipyridamole has been shown to inhibit certain lymphocyte populations that are over-reactive in lupus and to delay the emergence of lupus-related pathology in mice with lupus. the investigators are interested in investigating the efficacy of dipyridamole in preventing flares in patients with lupus and its impact on biomarkers of disease activity.

t cells in systemic lupus erythematosus (sle) express an abnormal phenotype characterized by increased effector functions and deficient regulatory responses. dipyridamole, a phosphodiesterase inhibitor extensively used in combination with low dose aspirin in secondary stroke prevention, has been proposed as a specific t cell directed treatment for sle. dipyridamole inhibits the calcium/calcineurin/nf-at pathway in sle t cells in vitro and abrogates expression of cytokines and costimulatory molecules, eventually also affecting b cell responses. dipyridamole delays the emergence of lupus related pathology in lupus prone mice, but has not yet been studied in humans with sle. the investigators aim to investigate the efficacy of dipyridamole in the prevention of flares in sle patients after withdrawal of background immunosuppressive medications. the investigators will additionally evaluate the safety and tolerability of dipyridamole and its impact on quality of life measures in this population. furthermore, the effect of dipyridamole on t and b cell biomarkers will be examined.

Eligibility criteria:
inclusion criteria: * patients with sle meeting the 1997 acr classification criteria * evidence of positive ana or anti-dsdna within one year of screening * sledai ≥4 or ≥1 bilag a or b at screening, despite standard of care exclusion criteria: * leukopenia (wbc \<2.000/mm3) or lymphopenia (lymphocytes \< 300/mm3) * ast or alt \>3 times above normal cut off values * acute lupus nephritis defined as class ii, iv or v nephritis diagnosed within 6 months or prot/creat \> 1.5 gm/gm due to active lupus or in process of receiving induction therapy for nephritis * active cns lupus affecting mental status * pregnancy or breast feeding * current requirement for anticoagulation * contraindication to aspirin or dipyridamole, including history of recent or severe gi bleeding, hemoglobin \<9 mg/dl, platelet count of \<30,000 /mm3 or unstable platelet count * any other medical condition, whether or not related to lupus which, in the opinion of the investigator would render the patient inappropriate or too unstable to complete the study protocol * inability or unwillingness to understand and/or sign informed consent

Keywords: lupus dipyridamole
follow-up of extreme neonatal hyperbilirubinemia in 5-10 year old children: a danish population based study

Conditions: Neonatal Hyperbilirubinemia

Summary: the objective of this study was to investigate whether infants with total serum bilirubin \> 450 umol/l in the neonatal period and no symptoms or no more than early acute bilirubin encephalopathy develop long term sequelae with impairment of motor development, hearing and executive function compared with a control group.

children in both the exposed and the non-exposed group were examined by use of the mabc-2 and pure tone audiometry by the responsible examiner for the study, pernille vandborg, md. the aim was to see whether the exposed group suffered any long term sequelae to the extreme neonatal hyperbilirubinemia, i.e. impaired motor development or hearing impairment, compared to a control group. the examinations took place at the local hospital.

Eligibility criteria:
inclusion criteria: * gestational age \> 35 weeks * total serum bilirubin \> 450 umol/l in the neonatal period * born in the period 01.01.2000 - 31.12.2005 exclusion criteria: * acute intermediate or advanced bilirubin encephalopathy

Keywords: neonatal hyperbilirubinemia follow-up motor development hearing executive function
emergence agitation in pediatric strabismus surgery

Conditions: Emergence Agitation

Summary: this study was performed to assess the effects of continuous remifentanil infusion and single bolus administration of fentanyl on the incidence of emergence agitation in pediatrics undergoing strabismus surgery.


Eligibility criteria:
inclusion criteria: * patients undergoing elective subumbilical surgery, * physical status was american society of anesthesiologists (asa) class 1 or 2 exclusion criteria: * history of airway problem, * upper respiratory tract infection within 2 weeks, * developmental delay, * neurological or psychological disease, * history of allergy to the drugs in our protocol were excluded in this study.

Keywords: emergence agitation fentanyl remifentanil children