Kornimate/medical-research-clean huggingface dataset:
processing of music in alzheimer patients

Conditions: Alzheimer Disease; Dementia; Amusia

Summary: correlation of musicality, brain atrophy in brain areas relevant for music processing and the stage of alzheimer´s disease.

alzheimer's disease (ad) is the most common cause of dementia accounting for 60-70% of all dementias. in most cases the cause for ad is unknown. the progression of ad is characterized by an advancing decline in cognitive skills and symptoms like impaired learning, memory deficits, language impairment and behavioral disturbances in later stages. the symptoms of ad are caused by cerebral atrophy which is the consequence of multiple pathological processes, including the formation of neurofibrillary tangles at neurites and amyloid plaques in the walls of cerebral blood vessels. ad is a major public health issue and its significance increases as the population grows older. music is thought to have preceded the development of spoken language as a form of communication and it has been used for therapeutic purposes in many ways throughout history. in patients with ad, musical memory has been noticed to be well-preserved and constituting a relatively independent part of memory. music-based neurological rehabilitation provides a mode of treatment, which is free of side effects and can be personalized for patients with dementia. aims of this study are to examine how ad affects the structure of various brain areas associated with music processing and to statistically correlate musical cognition with memory performance in patients with ad. focus is on brain areas associated with musical pleasure like the striatum, superior temporal gyrus, inferior frontal gyrus and areas associated with long-term musical memory like the anterior cingulate gyrus and presupplementary motor area. hippocampal atrophy serves as a reference of the stage of ad. our working hypothesis is that musicality correlates with preserved cognitive skills and memory. voluntary participants who have been diagnosed with ad are recruited from turku university central hospital. their musicality is assessed with a short version of montreal battery of evaluation of amusia which contains listening tasks that test the patients' memory, rhythm recognition and pitch discrimination. in addition, patients are asked to fill an inquiry that maps their use of music and its significance in their daily lives. voxel-based morphometry is applied on mri images to evaluate atrophy in the hippocampus and entorhinal cortex, which correlate with clinical stages of ad, as well as on the brain areas relevant for processing of music.

Eligibility criteria:
inclusion criteria: diagnosed alzheimer´s disease exclusion criteria: other neurological comorbidity, substance abuse
εffectiveness of intrauterine antibiotic administration for treatment of chronic endometritis

Conditions: Chronic Endometritis

Summary: chronic endometritis (ce) is related to infertility and entails a challenging management. this study investigates the treatment of off-label intrauterine antibiotic infusion either separately or combined with oral antibiotic administration, and it assesses respective performance against the gold standard treatment of oral antibiotic adminstration. data sourced herein reports on treatment efficiency, defined as a negative diagnosis for chronic endometritis.

an infectious endometrial environment caused by certain pathologies could compromise establishment of the initial interaction between the embryo and the endometrium. chronic endometritis (ce) is a case of a persistent endometrial inflammation caused by infectious agents namely escherichia coli, enterococcus faecalis, streptococcus agalactiae, mycoplasma, ureaplasma, and chlamydia. the perplexity of managing ce is attributed to its asymptomatic nature rendering a definitive diagnosis rather challenging. the list of potential symptoms is limited and vague while manifestation of the disease may be mild and may not correspond to severity. symptoms include pain in the pelvic cavity, dispareunia, uterine bleeding, vaginal infections and cystitis, and mild gastro-intestinal discomfort. ce is described as a chronic disorder due to its long duration and persistent nature, with potentially slow progression and complex causality, severely compromising reproductive potential of patients. the antibiotic treatments are primarily administered orally and endometrial re-examination is performed following treatment. it should be emphasized that apart from the differences in the types of antibiotics included, there are also significant discrepancies regarding the dosage of each antibiotic and the different schemes suggested by each practice. following the antibiotic regime, endometrial receptivity is anticipated to improve. however, a significant correlation between the antibiotic therapeutic approach and a positive results in ivf has failed to be established in literature, indicating that oral antibiotic administration is unseccessful in improving ivf outcome. a pilot study published by the investigators indicated that combination of intrauterine infusion of antibiotics and oral administration can be more effective in treating ce than solely oral administration. however, it has not been evaluated if sole intrauterine infusion of antibiotics can be of similar effectiveness when compared to the combined regime including intrauterine infusion and oral andministration, or when compared to the gold standard treatment including only oral administration of antibiotics.

Eligibility criteria:
inclusion criteria: * positive diagnosis of ce following hysteroscopy and endometrial biopsy (positive diagnosis is required by both evaluations) * signed informed consent * 18.5 \< bmi \< 30 exclusion criteria: * diagnosed endometriosis or other related pelvic inflammatory disorder (pid) * current or previous cancer diagnosis * auto-immune or genetic disorders * menstrual cycle disorders
impact of the enhanced recovery after surgery system for colorectal surgery

Conditions: ColoRectal Cancer and Inflammatory Bowel Disease

Summary: this is an observational study to look at the impact of the enhanced recovery after surgery system for colorectal surgery (group 1) in shortening hospital length of stay, reducing postoperative narcotic consumption, lowering visual analog scale scores, decreasing the incidence of postoperative nausea and vomiting, and reducing 30-day readmission when compared to patients who had colorectal surgery performed at uams prior to the implementation of the enhanced recovery after surgery system (group 2). this is a retrospective study using de-identified records and therefore will not require subject enrollment and is not human subjects research.

the enhanced recovery after surgery system for perioperative care of patients undergoing major abdominal surgery, particularly colorectal surgery, was formed in europe by a surgeon named henrik kehlet in 1994. dr. kehlet observed that his patients undergoing colorectal surgery were hospitalized postoperatively for extended periods of time due to prolonged return of the normal intestinal physiology and of other bodily functions. dr. kehlet formulated a system of perioperative care that focused on preserving and promoting faster return of normal physiologic function of the human body following surgery. the enhanced recovery after surgery system has been implemented in the united states for nearly a decade now, primarily at major academic institutions. numerous publications exist that report the dramatic positive impacts of this program on reducing postoperative hospital length of stay, reducing 30-day hospital readmissions, and improving patient satisfaction. the university of arkansas for medical sciences implemented several components of the enhanced recovery after surgery system for colorectal surgery in june 2015. this is an observational study to look at the impact that program (group 1) in shortening hospital length of stay, reducing postoperative narcotic consumption, lowering visual analog scale scores, decreasing the incidence of postoperative nausea and vomiting, and reducing 30-day readmission when compared to patients who had colorectal surgery performed at university of arkansas for medical sciences prior to the implementation of the enhanced recovery after surgery system (group 2).

Eligibility criteria:
inclusion criteria: * all men and women 18 years and older who underwent major colorectal surgery at university of arkansas for medical sciences between january 1, 2014 to december 31, 2014 and june 1, 2015 to november 30, 2016, and were american society of anesthesiologist physical status classification 1-3 at the time of surgery. exclusion criteria: * american society of anesthesiologists physical status classification \> 3 and age \< 18.
clinical study of cord blood mononuclear cells (ucb-mncs) in the treatment of knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: umbilical cord blood mononuclear cells contain hematopoietic stem cells (hsc), mesenchymal stem cells (msc), endothelial progenitor cells and other pluripotent stem cells, as well as immature immune cells, which can differentiate into chondrocytes, hematopoietic, epithelial, endothelial and nerve cells. it gives the ability to promote wound healing and vascular microcirculation reconstruction, and has the potential to treat many diseaseshowever, clinical studies on cord blood mononuclear cells in knee osteoarthritis have not been reported in the literature. therefore, this study aims to explore the safety and effectiveness of cord blood mononuclear cells in the treatment of patients with knee osteoarthritis.


Eligibility criteria:
inclusion criteria: * age ≥30 years old, ≤75 years old, no gender limit; * meet the koa diagnostic criteria in the "classification criteria for knee osteoarthritis" revised by the american college of rheumatology (acr); * according to the x-ray k-l grading and evaluation standard, it is at level ii-iii; * continuous pain for at least 6 months; * no local or systemic infection; * there is no obvious contraindication for articular cavity puncture in hematology and biochemical testing; * subjects and their families understand the clinical trial protocol and agree to participate in the trial, voluntarily and sign an informed consent form; exclusion criteria: * age\<30 years old; * tumor diseases; * severe kidney, lung or liver damage; * blood diseases include anemia and thrombocytopenia; * type i diabetes; * severe effusion; * contracture or instability of the knee joint, with an axial deformity greater than 10°; * infectious arthritis or skin disease; * inject corticosteroids and immunosuppressants into the knee joint within 2 months; * suffer from mental illness and poor compliance; * cases that the investigator thinks are not suitable for inclusion in the group.

Keywords: cord blood mononuclear cells knee osteoarthritis
safety and efficacy study of mt-2990 in women with endometriosis

Conditions: Endometrial Related Pain

Summary: the purpose of this study is to assess the safety and efficacy of mt-2990 for treatment of moderate to severe endometriosis-related pain in women with surgically diagnosed endometriosis.


Eligibility criteria:
inclusion criteria: * provide written informed consent to participate in this study * agree to approximately 30-90 day washout interval of hormonal therapies, if applicable * have a history of regular menstrual cycles * have a body mass index \< 45 kg/m\^2 (inclusive) * have documented surgical/laparoscopy diagnosis of endometriosis with 10 years * agree to use 2 forms of nonhormonal contraception throughout the study * in the investigator's opinion, subject is able to understand the nature of the study and any risk involved in participation, and is willing to cooperate and comply with the protocol restrictions and requirements including transvaginal ultrasound. * have moderate to severe endometrial related pain exclusion criteria: * subject is pregnant, breast feeding, or planning a pregnancy. * subject is \< 6 months postpartum, postabortion, or post-pregnancy. * willing to remove a hormonal intrauterine device (iud) at least 30 days prior to screening. (non hormonal iuds do not have to be removed) * aspartate aminotransferase (ast), alanine aminotransferase (alt) , or total bilirubin ≥ 2.0 × upper limit of normal (uln) above the reference range * have immunosuppression due to underlying medical condition * corrected qt interval using fridericia's formula (qtcf) or corrected qt interval using bazett's formula (qtcb) ≥ 450 msec or clinically important abnormal findings on the ecg * subject is not up-to-date on breast screening according to current guidelines. * has a surgical history of hysterectomy, bilateral oophorectomy and any other recent major surgery * subject is required more than 2 weeks of continuous use of prohibited long-acting narcotic or immediate release narcotic for treatment of endometriosis-associated pain. * have chronic pelvic pain for nonendometriosis related causes, which require systemic pharmaceutical chronic therapy for pain * have other chronic pain syndrome which require chronic analgesic or other chronic therapy * have a clinically significant gynecologic condition identified on the transvaginal ultrasound (tvu) (e.g., complex ovarian cyst \> 3 cm or simple ovarian cyst \> 5 cm, clinically significant endometrial pathology, single fibroid ≥ 4 cm or multiple (\> 4) fibroids that measure ≥ 2 cm or symptomatic submucosal fibroid of any size * have a current history of undiagnosed abnormal genital bleeding

Keywords: endometriosis
the use of low dose metronidazole to decrease postoperative pain after endometriosis surgery

Conditions: Endometriosis; Endometriosis-related Pain

Summary: the purpose of this study is to determine a difference in participant reported pain after endometriosis surgery in participants given oral metronidazole versus placebo.

the study is a prospective, randomized, placebo-controlled trial. women scheduled for endometriosis surgery between 18-50 years of age will be invited to participate in the study. participants with surgically staged endometriosis will be randomized to the metronidazole plus routine postoperative care arm or the placebo plus routine postoperative care arm. participants will take study or placebo drug for a total of 14 days. participants will complete surveys at baseline and postoperatively at 6 weeks, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years reporting intensity of endometriosis associated pain on a visual analog scale, pregnancy outcomes, quality of life, and sexual health.

Eligibility criteria:
inclusion criteria: * able to give informed consent * women aged 18-50 years old * scheduled to undergo excision of endometriosis * able to read and write in english and or spanish * pain score \> 2 on a 10 point visual analogue scale at baseline * negative screening by cage questionnaire exclusion criteria: * refusal to surgery * contraindication to surgery * known allergy to metronidazole * known allergy to any component in gelatin placebo capsules * scheduled hysterectomy * endometriosis excision surgery within the last 3 months * elevated serum creatinine * abnormal liver function test greater than 2 times the normal * current pregnancy * breastfeeding * use of disulfiram within the last 2 weeks * history of cockayne syndrome * inability to abstain from alcohol during the use of study drug
erector spina plane block for multilevel major spinal surgery

Conditions: Pain; Post Operative Pain

Summary: erector spinae plane (esp) block is an interfacial plane block with visceral and somatic analgesic activity at paraspinal muscles. this study aims to examine the postoperative analgesic efficacy of esp block in patients undergoing posterior spinal instrumentation

postoperative patient-controlled analgesia in the esp group and control group will be compared with 24-hour morphine consumption and nrs scores at different time points. in addition, the need for rescue analgesics and patient satisfaction will be evaluated.

Eligibility criteria:
inclusion criteria: * asa i-iii patients * agreed to participate in the study exclusion criteria: * patients with infection at the injection site * coagulopathy allergy to amide-type local anesthetics * history of peripheral neuropathy * hepatic and/or renal failure * refusing the procedure * patients with heart disease * patients who have previously undergone surgery from the same area

Keywords: pain postoperative analgesia erector spinae plane block posterior spinal instrumentation
birth rate in conservative monitoring of pregnancy beyond the date of birth.

Conditions: Pregnancy, Prolonged

Summary: pregnant women beyond the date of birth. will be followed while coming to routine monitoring. physiological parameter of cervical length will be measured as the differential predictor to determine their due date. the cervical length will be measured as part of routine gynecologic examination to women who come for routine over due date follow up. additional medical data will be collected from the patient medical record.- demographic data, and all the routine prenatal medical care the women will receive up to the delivery.and delivery outcomes.

the clinical part of the study: the first visit of pregnancy monitoring is carried out at 40 full weeks. first visit to make sure the gestational age to receive full medical anamnesis , perform physical examination and vaginal and nst and bpp. also, assess the clinical weight and when the need arises assessment of weight sonography. monitoring fetal movements . the women are ordered to return for routine check ups every 3 days. from - 41 full weeks the women should come every two days and 42 weeks should be referred for induction. in practice, the women offered induction at 41 weeks + 3 or 4 days.

Eligibility criteria:
inclusion criteria: 1. age 18-50 . 2. individual fetus 3. the dating of gestational age based on first- trimester ultrasonography or by last menstrual 4. gestational age between 39 weeks and 0 days to 41 weeks and 6 days . 5. the pregnant women is not in pain ( vas \<3 ) while signing on consent to participate. 6. normal fetal monitoring measures and sonar 7. expectant mother is in active labor 8. consent to participate exclusion criteria: 1. multi-pass pregnancy 2. without accurate dating of gestational age based on first- trimester ultrasonography or by last menstrual 3. indicators for abnormal fetal monitoring and / or sonar 4. active labor 5. pain ( vas \> = 3 ) 6. expectant mother does not agree to participate or delivery if consent was given earlier
determining oral phosphate tolerance across the spectrum of glomerular filtration rate

Conditions: Chronic Kidney Disease

Summary: over 20 million people in north america (including 2 million canadians) have chronic kidney disease. these individuals die from diseases of the heart and blood vessels more often than they need dialysis. this is due to hardening of the arteries caused by calcium deposits inside the blood vessel walls. these deposits damage the vessels, causing them to lose flexibility. this makes them unable to respond to the changing demands of the body, and eventually leads to blockages such as stroke and ultimately death. high levels of phosphate in the blood have been consistently linked to the development of calcium deposits inside blood vessel walls. the kidney is the only organ in the body that can eliminate phosphate that is not required by the body. as kidney function becomes worse, body levels of phosphate increase. however, investigators do not know the time point in the course of kidney disease that problems begin in the way phosphate is eliminated into the urine by the kidneys. investigators will test the response of the kidneys to a phosphate challenge taken by mouth in subjects who are having accurate measures of kidney function performed by a method called 'inulin clearance'. the investigators believe that the results of this study will provide important information identifying when investigators should be concerned about body levels of phosphate increasing. this information may lead to changes in the way investigators treat patients by reducing the levels of phosphate in the diet at a much earlier time point then is presently recommended.

fractional excretion of phosphate will be measured pre- and 60 minutes and 120 minutes following an oral challenge of 500 mg of oral phosphate in a group of patients with gold standard measures of glomerular filtration rate.

Eligibility criteria:
inclusion criteria: * stable chronic kidney disease exclusion criteria: * unable/unwilling to give informed consent; * pregnant or breast-feeding; * known allergy to shellfish, iodine or inulin; * have evidence of impaired bladder emptying defined as a post-void residual of greater than 20 ml.
multimodal targeted axillary surgery

Conditions: Node-positive Breast Cancer

Summary: the present trial will prospectively evaluate the accuracy of both a systematic predefined axillary ultrasound imaging together with tumor load quantification of suspicious and sentinel axillary lymph nodes to predict overall tumor load in the axilla.

axillary node clearance (anc) is a controversial intervention in the surgical treatment of breast cancer. different studies have shown that in some patients with infiltrated axillary lymph nodes but low tumor burden, anc can be safely omitted. however, indications for anc persist in nowadays for patients with positive axillary lymph nodes and upfront surgery and patients with positive lymph nodes after neoadjuvant treatment. the present prospective study will evaluate the ability to establish an axillary tumor load with two steps. the first step will be a preoperative predefined systematic axillary ultrasound imaging workflow. the second step will be the tumor load evaluation of suspicious and sentinel axillary lymph nodes. we will also evaluate which patients have infiltrated nodes only beneath the second intercostobrachial nerve. the trial intends to identify patients for who a complete axillary node clearance could be spared.

Eligibility criteria:
inclusion criteria: * node-positive breast cancer patients confirmed by biopsy or cytology * positivity confirmed before the surgical treatment exclusion criteria: * inability to confirm positive lymph nodes by biopsy or cytology * inability to understand the protocol design * poor understanding of the spanish language

Keywords: axillary node clearance axillary ultrasound imaging sentinel node tumor load