Kornimate/medical-research-clean huggingface dataset:
diagnosis of hypertension by home blood pressure monitoring

Conditions: Hypertension,Essential; Home Blood Pressure; Ambulatory Blood Pressure

Summary: home blood pressure measurement has been recommended to use in the diagnosis of hypertension. the investigators have developed diagnostic algorithm of hypertension by using 24-hour and home blood pressure measurement. however, the diagnostic agreement between home blood pressure measurement and 24-hour ambulatory blood pressure measurement is about 70 - 85%. the discrepancy of diagnosis between home blood pressure measurement and 24-hour ambulatory blood pressure is one of the barriers to introduce home blood pressure measurement in the diagnosis of hypertension. to solve the discrepancy, identifying the characteristic patients showing discrepancy of hypertension diagnosis between home blood pressure measurement and 24-hour ambulatory blood pressure measurement is needed. the purpose of the present study are (1) to validate the diagnostic algorithm of hypertension by using 24-hour ambulatory blood pressure and home blood pressure measurement the investigators have developed, and (2) to identifying the characteristics of patients showing discrepancy of diagnosis between 24-hour ambulatory blood pressure and home blood pressure measurement, and (3) lastly to improve the diagnostic algorithm of hypertension by using home blood pressure measurement.


Eligibility criteria:
inclusion criteria: * men and women * patients with high blood pressure measured by doctors at the outpatient office exclusion criteria: * patients taking antihypertensive drugs or blood pressure affecting drugs within 1 month * secondary hypertension * hypertensive emergency and urgency * severe heart failure (nyha iii and iv) * angina with 6 months * myocardial infarction within 6 months * peripheral artery disease within 6 months * significant arrhythmia (i.e. ventricular tachycardia and fibrillation, atrial fibrillation, atrial flutter) * pregnancy * night labor, shift worker * those who are currently participating in other clinical studies * those who have taken other clinical trial drugs within the past month * according to the opinion of the researcher, those who have or may have a disease that may interfere with the completion of the study * history of drug or alcohol dependence within 6 months
drug use study with intuniv® in european countries

Conditions: Attention Deficit Hyperactivity Disorder (ADHD)

Summary: this study will evaluate and characterize people who are taking intuniv, analyze prescribing behaviors of physicians, and determine whether intuniv was correctly prescribed in belgium, denmark, finland, germany, ireland, netherlands, norway, spain, sweden, and the united kingdom.

the study aims to characterize participants who are prescribed intuniv® and describe prescribing patterns of intuniv® among physicians in european countries. this study will collect data from the following sources: * physician survey: de-identified patient data provided by representative physicians in belgium, finland, ireland, and the netherlands, with a goal of data from up to 100 participants per survey wave. * database survey: longitudinal patient-level prescription database in all other countries with data on approximately 5000 participants. in the database study, actual prescription data are collected from electronic medical records and national registries. a prescriber survey will be conducted to evaluate health care professionals (hcps) real-life practice. it will include data collection from the prescriber's (physician's) files and a web questionnaire, including de-identified data from up to 100 participants per survey wave.

Eligibility criteria:
inclusion criteria: * prescribers of intuniv®, i.e. physicians who know and have prescribed the drug at least once during the previous 12 months (or, for the first report, since country specific launch) (paediatricians, psychiatrists, neurologists and gps). * participants who have been prescribed intuniv® at least once during the reporting period. exclusion criteria: • physicians who do not treat participants or who may have a conflict of interest (i.e. physicians employed by regulatory bodies or pharmaceutical industries).

Keywords: drug therapy
intravenous lidocaine for fibromyalgia

Conditions: Fibromyalgia

Summary: the effect of intravenous lidocaine infusion on manifestations of fibromyalgia manifestations were recorded before and 4 weeks after treatment. pain intensity was rated on a numerical scale.the combination of 240 mg intravenous lidocaine (once a week) and 25 mg amitriptyline for 4 weeks did not modify pain intensity or manifestations in patients with fibromyalgia.

thirty patients ranging in age from 18 to 60 years, with fibromyalgia (american college of rheumatology criteria: pain in the four quadrants of the body for at least 3 months and a minimum of 11 out of 18 tender points) were studied. other manifestations were also recorded: sleep disorders, fatigue, subjective edema, depression, and paresthesia. criteria for exclusion were alterations in thyroid, rheumatological, renal and hepatic function; trauma; rheumatic, neuromuscular or psychiatric disease; infectious arthropathy; other pain syndromes; drug hypersensitivity, and pregnancy. all patients received amitriptyline at a dose of 12.5 mg in the first week and 25 mg over the subsequent 4 weeks. patients of group 1 (n = 15) received 125 ml 0.9% saline and patients of group 2 (n = 15) received 240 mg lidocaine diluted in 125 ml 0.9% saline. the solutions were infused over a period of 1 h, once a week, for 4 weeks (t1, t2, t3 and t4).

Eligibility criteria:
inclusion criteria: * 18 to 60 years, with fibromyalgia (american college of rheumatology criteria: pain in the four quadrants of the body for at least 3 months and a minimum of 11 out of 18 tender points exclusion criteria: * thyroid, rheumatological, renal and hepatic function * trauma * rheumatic, neuromuscular or psychiatric disease * infectious arthropathy * other pain syndromes * drug hypersensitivity; and * pregnancy

Keywords: lidocaine fibromyalgia intravenous lidocaine manifestations
aquatic sequential preparatory approach and severe traumatic brain injury

Conditions: Traumatic Brain Injury; Severe Traumatic Brain Injury

Summary: traumatic brain injury (tbi) is an acquired insult to the brain from an external mechanical force. it is considered a major cause of mortality and of long-term disabilities in young adults, especially considering high-income countries. the tbi can cause a wide range of temporary and/or permanent brain's dysfunctions that can involve physical, cognitive, behavioural and emotional functioning limiting everyday life and social activities and leading to a lowers quality of life. a sequential preparatory approach (spa), performed in aquatic environment, based on increasing difficulty and following a specific sequence of preparatory exercises (from the simplest to the most complex) could be an effective complementary training during post-acute intensive rehabilitation in patients with severe traumatic brain injury (stbi).


Eligibility criteria:
inclusion criteria: * age between 15 and 65 years; * glasgow coma scale (gcs) score ≤ 8 (used to objectively describe the severity of impaired consciousness at the time of injury) * level of cognitive functioning (lcf) ≥7; * ability to understand verbal commands. * acclimatization to water. exclusion criteria: * cognitive deficits affecting the ability to understand task instructions (mini-mental state examination \> 24); * severe unilateral spatial neglect (diagnosed with a test battery that included the letter cancellation test, barrage test, sentence reading test and the wundt-jastrow area illusion test); * severe aphasia (diagnosed by means of neuropsychological assessment); * presence of other neurological diseases; * presence of cutaneous and mycosis infections; * presence of open wounds, eczema, skin ulcers, decubitus lesions, severe burns; * presence of peg (percutaneous endoscopic gastrostomy); * presence of tracheostomy; * urinary incontinence; * presence of otitis * presence of orthopedic or cardiac comorbidities that would limit participation in the experimental and conventional training (all of which were clinically evaluated).
can arm and leg cycling exercise improve walking after stroke

Conditions: Cerebrovascular Accident

Summary: it has been found that arm and leg cycling is similar to walking. thus, the objective of this research is to determine if arm and leg cycling can be used to improve walking ability in a post-stroke population. this outcome would directly impact the health and quality of life for those who have suffered a stroke.

it has been found that arm and leg cycling is similar to walking in terms of the muscle activation patterns, joint ranges of motion, and neural pathways activated. another advantage of arm and leg cycling is that it involves coordination of all four limbs in a rhythmic movement. this may be particularly beneficial given previous findings that arm movement contributes to the activation of leg muscles during walking in humans. this is achieved with interconnected neural pathways that link the arms to the legs. these neural interlimb connections remain intact in stroke victims, such that maximizing the contribution of the arms to the legs may increase coordination for walking. thus, the objective of this research is to determine if arm and leg cycling can be used to increase the strength of inter-limb connections and if this helps to improve walking ability in a post-stroke population. 15-20 participants will be recruited to participate in a five week training intervention where measures will be taken before and after the intervention to assess efficacy. arm and leg cycling could provide a novel method to improve inter-limb coupling and walking ability. these outcomes would directly impact the health and quality of life for those who have suffered a stroke.

Eligibility criteria:
inclusion criteria: * cerebrovascular accident exclusion criteria: * inability to stand
acute effects of physical activity on memory, cognitive performance and brain activity

Conditions: Mental Health Wellness 1

Summary: the overall aim of the study is to investigate the effects of an acute bout of physical activity on cognitive performance and long-term memory in elementary school children. elaborating, the study seeks to investigate the effect of the intensity of the physical activity on cognitive performance and long-term memory in preadolescent children.

based on a power analysis a total population of 100 children (four school classes) will be invited to participate in a 10-day protocol. the children will be randomly allocated, within their cluster (classes) and stratified for gender and soccer level, to one of 3 intervention groups. the groups consist of: a small-sides soccer game group (ssg), a walking soccer group (wsg) and a rest group watching soccer on tv (res). at day 1 the children will complete a screening of their physical characteristics (height, weight, fat percentages, lean muscle mass and fitness status). on day 2 the children will complete a screening and a familiarization to the cognitive tasks used (cognitive performance and long-term memory) and the brain activity measuring devices (transportable eeg systems). on day 3 the children will complete the interventions, which first consist a long-term memory task, where the children will be asked to remember forty different pictures. immediately after exposure to the forty pictures, the children will participate in 2 x 10 minutes of their respective interventions with 5 minutes break in between. during the break, the children will complete a short questionnaire to address their flow. furthermore, during the intervention they will be equipped with heart rate monitors to quantify the physical demands of the intervention. immediately after completing the 2 x 10 minutes interventions the children will be equipped with a transportable eeg system, and undergo a cognitive test (the flanker task) to address their cognitive performance. the eeg recordings are used to measure the p3 amplitude and latency, biomarkers for cognitive performance. while equipping the children with the eeg system, the children will complete questionnaires about their participation. at day 10 the children will try to remember as many pictures of the forty pictures as possible to address the effect of the interventions on their long-term memory.

Eligibility criteria:
inclusion criteria: * informed consent from the childrens´ legal guardians. * physical, linguistic and mental competencies to complete the intervention and testing. exclusion criteria: * use of prescription-only drugs that kan affect learning ability. * smoking. * neurological diseases inclusive damages to the spinal cord. * children who is not evaluated to being cable of completing the protocol among these psychological diseases or psychological unstable children.

Keywords: cognition physical activity memory health
safety, tolerability and pharmacodynamics of cyt013-il1bqb in patients with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this clinical trial is to test safety and tolerability of a vaccine targeting interleukin-1 beta in patients with type 2 diabetes.


Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes mellitus, according to the american diabetes association diagnostic criteria, ≥ 3 months at time of randomization * hba1c in the range of 6.5 - 9.5% (inclusive) at screening * treatment with diet and exercise alone or a stable dose of metformin, or sulfonylurea, or metformin plus a sulfonylurea for at least 4 weeks prior to randomization * further criteria as defined in the clinical trial protocol exclusion criteria: * symptoms of hyperglycemia (i.e. polyuria and polydypsia) * history of significant weight gain or loss (+/-5%) during the 4 weeks before randomization * fasting c-peptide level \< 400 pmol/l at screening * change in the medicamentous treatment of elevated blood pressure, diabetes mellitus or dyslipidemia within 4 weeks prior to the randomization * use of any weight loss medication (over the counter prescription) or initiation of a prescribed weight management or exercise program within 4 weeks before randomization * current systemic anti-inflammatory therapy other than aspirin ≤ 100 mg/day or immunosuppressive treatment, in particular oral corticosteroids
genetic polymorphism as moderator of the effect of an acute bout of exercise on cognitive function

Conditions: Executive Function

Summary: studies have shown that an acute bout of aerobic exercise positively effects cognition, mainly executive functioning; however the effect is not observed among all people and it is not clear whether only aerobic exercise can produce this effect or possibly also resistant exercise. the main purpose of our study is to examine whether genetic variation is a moderator of this effect and whether resistant exercise is comparable to aerobic exercise in improving cognition following a single bout of exercise.


Eligibility criteria:
inclusion criteria: * physical education students * able to sign consent form exclusion criteria: * competitive athletes * smokers * neurologic or psychologic orders * chronic diseases * head injuries * hospitalization in the previous 3 months * pregnant
will the use of triesence during glaucoma surgery provide lower eye pressure and improve the results of the surgery?

Conditions: Glaucoma

Summary: the investigators hypothesize that intracameral triesence during glaucoma surgery will provide lower intraocular pressure through better control of ocular inflammation, thus leading to a more successful filtering procedure.

determine the efficacy and safety of intracameral triesence in patients who undergo trabeculectomy, tube shunt, or combined cataract extraction, intra-ocular lens implantation and trabeculectomy with or without adjunctive mitomycin-c.

Eligibility criteria:
inclusion criteria: * glaucoma patients requiring surgery (trabeculectomy or express shunt; trabeculectomy plus phacoemulsification and interocular lens implant; baerveldt tube; ahmed tube; molteno tube) * primary open angle glaucoma * primary angle-closure glaucoma * pseudoexfoliation glaucoma * pigmentary glaucoma * traumatic glaucoma * neovascular glaucoma exclusion criteria: * patients that are pregnant, nursing, or not using adequate contraception * any other eye surgery except cataract surgery * an infection, inflammation, or any abnormality preventing measurement of eye pressure * enrolled in another investigational study

Keywords: open angle glaucoma (poag) angle closure glaucoma (pacg) pigmentary glaucoma pseudoexfoliation glaucoma neovascular glaucoma traumatic glaucoma
the initial double-blind drug-eluting stent vs bare-metal stent study.

Conditions: Coronary Artery Disease

Summary: the main objective of this study is to assess the safety and effectiveness of the sirolimus coated bx velocity stent in reducing angiographic in-stent late loss in de novo native coronary lesions as compared to the bare metal bx velocity balloon-expandable stent. both stents will be mounted on the raptor rapid exchange delivery stent system.

this is a multicenter (19 sites), prospective, randomized study. this study has a 2 arm design assessing the safety and effectiveness of the sirolimus coated bxtm velocity stent to the bare metal bxtm velocity stent, both mounted on the raptorâ rapid exchange stent delivery system. a total of 220 patients will be entered in the study and will be randomized on a 1:1 basis. patients will be randomized to the coated or uncoated bx velocity stent. therefore, neither the investigator nor the patient will know which stent will be implanted. patients will be followed for twelve months post-procedure, with all patients having a repeat angiography at 6 months. an ancillary study with in-stent ivus measurements at 6 months follow-up will be performed in all patients of 6 pre-selected clinical sites. it is assumed that these sites will enroll more than 90 patients.

Eligibility criteria:
inclusion criteria: 1. diagnosis of angina pectoris as defined by canadian cardiovascular society classification (ccs i, ii, iii, iv) or unstable angina pectoris (braunwald classification b\&c, i-ii-iii) or patients with documented silent ischemia; 2. single treatment of de novo lesion in a coronary artery which can be appropriately covered by a study stent of 18mm in length in patients with single or multivessel disease; patients with multiple lesions can be included only if the other lesions do not require treatment; 3. target lesion is \>= 2.5 and \<= 3.5mm in diameter (visual estimate); 4. target lesion is located in a native coronary artery which can be covered by one stent (single lesion); 5. target lesion stenosis is \>50% and \<100% (timi i) (visual estimate). exclusion criteria: 1. a q-wave or non-q-wave myocardial infarction within the preceding 72 hours unless the ck and ck-mb enzymes are back to normal; 2. unprotected left main coronary disease with \>=50% stenosis; 3. have an ostial target lesion; 4. angiographic evidence of thrombus within target lesion; 5. calcified lesions which cannot be successfully predilated; 6. ejection fraction \<=30%; 7. totally occluded vessel (timi 0 level); 8. target lesion involves bifurcation including a side branch \>=2.5mm in diameter (either stenosis of both main vessel and major branch or stenosis of just major branch) that would require side branch stenting which is likely to occur if side branch is diseased and intended to be stented; 9. planned direct stenting.
mowi home-based pilot

Conditions: Obesity

Summary: the goal of this study is to conduct a program of pilot research aimed at developing and evaluating a technology-assisted wellness intervention for older adults with obesity.

the national epidemic of obesity is also affecting older adults, and is associated with an increased risk of disability, nursing home placement and early mortality. conventional weight loss programs have the potential to reduce body fat, but are difficult to access for older obese adults due to transportation and mobility challenges. the overarching goal of this study is to conduct a program of pilot research aimed at developing and evaluating a technology assisted wellness intervention for older adults with obesity. study timeline: september 2018 to april 2021: goal: conduct a study of improving weight and physical function in older adults with obesity at home using video-conferencing. an mhealth obesity wellness intervention (mowi) will integrate a fitness device with a weekly individual dietician-led nutritional session, along with twice weekly physical therapist led group exercise session performed in a person's home. participation duration: three times weekly for 6 months. we shall also have participants return to the center once monthly

Eligibility criteria:
inclusion criteria: * age ≥65 years * body mass index (bmi) ≥ 30kg/m\^2 or waist circumference ≥88cm in females or ≥102cm in males * have wi-fi high speed internet * able to obtain medical clearance from doctor * have less than a 5% weight loss in past 6 months * no advanced co-morbidity * no exercise restrictions * not involved in other research studies that may interfere with participation exclusion criteria: * severe mental or life-threatening illness * dementia * substance use * history of bariatric surgery * suicidal ideation * unable to perform measures * reside in nursing home * no advanced co-morbidity * no exercise restrictions * not involved in other research studies that may interfere with participation

Keywords: frail elderly telemedicine obesity rural health health promotion weight loss
breakfast for young females

Conditions: Overweight and Obesity; Overweight Adolescents; Metabolic Disease

Summary: investigators will test the health effects of eating a dairy-based protein-rich breakfast or isocaloric breakfast and performing regular physical exercise training for 12 weeks in young overweight women (2 x 2 factorial design). measurements of body composition, physical fitness, metabolic health parameters, faeces and urine metabolites, and food diary will be collected.

the study is a 2×2-factorial randomized controlled trial with 4 study arms. one-hundred (100) subjects will be randomly allocated to eat breakfast consisting of high-protein yoghurt (300g/day) with oats or an isocaloric breakfast consisting of bread, jam and juice matched for fat and fiber content and to either exercise 3x per week or maintain habitual physical activity for 12 weeks. measurements and biological sampling will be performed at baseline, half way (some parameters only) and at the end of the intervention period. the primary outcome will be fat mass and fat free mass determined by dxa. the investigators will also measure effects on weight, waist, health-related blood parameters, muscle function, physical activity, habitual food intake and metabolites in faeces, urine and blood.

Eligibility criteria:
inclusion criteria: * body mass index \> 25 * regular exercise \< 1 hour per week exclusion criteria: * illness and use of medication affecting the study outcomes * allergy towards milk and yoghurt * weightloss/gain \>5kg the last 6 months * dieting * eating disorder * pregnancy * breast feeding * unable to speak and understand danish

Keywords: dairy protein breakfast content body composition muscle strength gut microbiota/microflora dietary recommendations exercise training