Kornimate/medical-research-clean huggingface dataset:
effectiveness of a decision aid for knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: the main goal of this study is assess the effectiveness of a da for patients with knee osteoarthritis candidates to art

the number of knee total arthroplasty (art) interventions has increased in the last 10 years in european countries, partly due to the aging of the population and partly because of the increase in the use of these interventions to improve the quality of life among elderly patients. according to the organization for economic cooperation and development (oecd) 2012, from 2000 to 2010 in spain the percentage of knee art has doubled in recent years. . the role of citizens in decisions affecting their health is changing. individual factors such as improving educational attainment and access to medical information, and collective factors such as training of patient groups and changes in legislation (informed consent, autonomy principle) have motivated the transition from a paternalistic model to a co-responsibility model. shared decision-making (tdc) has been proposed in recent years as a model of care that promotes users' involvement in the decisions about their treatment, in those situations where there is uncertainty and / or the scientific evidence reports a balance between benefits and risks that is similar for two or more therapeutic options. decision aids (da) are tools designed to promote and facilitate patients' involvement in medical decisions concerning their health objectives: to assess the effectiveness of a da for patients with knee osteoarthritis candidates to art methodology: randomized controlled trial to evaluate the effectiveness of the da versus usual care in reducing decisional conflict, increasing knowledge of the disease/treatments, informed choice and the satisfaction with the decision making process, and decreasing decisional regret.

Eligibility criteria:
inclusion criteria: * patients with osteoarthritis of the knee * candidates for arthroplasty exclusion criteria: * patients who have already undergone knee arthroplasty * patients younger than 18 years

Keywords: knee ostheoartritis arthroplasty clinical trial decision aids
prevention of depression in spouses of people with cognitive impairment

Conditions: Depression

Summary: this study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or family caregivers of persons with mild cognitive impairment or early dementia.

people with a diagnosis of mild cognitive impairment (mci) have an estimated 12% probability each year of progressing to a dementing disorder. pilot data suggest that the spouses of people with mci begin to adopt the caregiver role and its burdens as they cope with this condition. although levels of caregiver burden and psychiatric illness are lower than those typically observed in family dementia caregiving samples, our findings suggest that mci spousal caregivers have already begun to experience distress associated with elevated caregiver burden. in order to protect the mental health and well-being of caregivers as they cope with their spouses' current and future health care needs, it may be ideal to implement selective preventive strategies while they are in the very earliest stages of caregiving. this study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or significant others of people with mci. participants in this open-label study are randomly assigned to receive either a self-management intervention targeted at problem-solving training or an attention-matched intervention targeted at nutritional education. the self-management intervention trains participants to effectively use problem-solving skills with the aim of strengthening their ability to cope with burdens of caregiving and preventing the onset or worsening of depression. the nutritional education program is based on the new united states department of health and human services 2005 dietary recommendations. all participants attend weekly individual training sessions, either in their home or another convenient location for a total of 6 weeks. at the end of 6 weeks, participants receive a weekly phone call for an additional 3 weeks to support the training they received. follow-up data is collected at months 1, 3, 6, and 12 post-intervention. if a participant's spouse is diagnosed with dementia during the study, additional follow-up data is collected after the month 12 visit.

Eligibility criteria:
inclusion criteria: * spouse or non-married partner of a patient being treated at the university of pittsburgh alzheimer's disease research center (adrc) for a new or subsequent diagnosis of mci exclusion criteria: * does not speak english * cohabitating adult child of a person with mci * resides in an institutional or assisted-living setting

Keywords: anxiety mild cognitive impairment mci cognitive impairment alzheimer's disease caregiver burden caregiver stress family dementia caregiving spousal dementia caregiving
macular thickness and visual acuity in diabetic hypertensive patients

Conditions: Macular Edema

Summary: in this study, measurements of central macular thickness using optical coherence tomography along with examination of visual acuity by snellen's chart in diabetic hypertensive patients will be done .

correlate relationship between optical coherence tomography changes and visual acuity in patients with type 2 diabetes and hypertension

Eligibility criteria:
inclusion criteria: * type 2 diabetic patients with hypertension . exclusion criteria: * patients with type 1 diabetes mellitus . * ocular disease ( such as high myopia , glaucoma ) . * patients with opacities in the media ( corneal opacities , dense cataract , vitreous hemorrhage ) . * systemic medication (tamoxifen , chloroquine , canthaxanthine ) to avoid its effect on macular thickness . * central visual field defect that prevents fixation on oct . * intraocular inflammation such as anterior or posterior uveitis . * refractive error greater than 6 diopter .

Keywords: macular thickness and visual acuity
multicenter observational study on myocardial iron overload in 3 multitransfused populations

Conditions: Thalassemia; Sickle Cell Disease; Myelodysplasia

Summary: the investigators' primary objective is to study prevalences of myocardial iron overload, defined as a cardiac t2\*\< 20 ms, in 3 populations of multiply transfused patients, affected with thalassemia, sickle cell disease, and myelodysplasia.

the inevestigators' primary objective is to study prevalences of myocardial iron overload, defined as a cardiac t2\*\< 20 ms, in 3 populations of multiply transfused patients, affected with thalassemia, sickle cell disease, and myelodysplasia. the investigators will record concomitantly parameters which, according to literature data, may influence the occurrence of this complication, and will look for correlations with these parameters and iron overload (secondary objectives), in each of the 3 cohorts. 14 centres are involved and enrol patients with thalassemia, or sickle cell disease, or myelodysplasia having received in the past year \> 8 erythrocyte concentrates, and having had a cardiac mri. patients files register the type of the disease, age at the beginning of transfusion and chelation, chelator type and dosage, liver and cardiac t2\*.

Eligibility criteria:
inclusion criteria: * thalassemia, sickle cell disease, myelodysplasia * having received in the past year \> 8 erythrocyte concentrates * \> 6 years of age exclusion criteria: * preexisting cardiac disease

Keywords: thalassemia sickle cell disease myelodysplasia transfusion chelation
to evaluate the efficacy and safety of micafungin in preventing invasive mycosis after liver transplantation

Conditions: Liver Transplantation

Summary: to evaluate the clinical success rate of micafungin in preventing invasive mycosis after liver transplantation.


Eligibility criteria:
inclusion criteria: 1. sign the informed consent form voluntarily; 2. liver transplant patients with 1 high-risk factor; a. transplant again; b. fulminant liver failure; c. renal failure requires alternative treatment (defined as creatinine clearance ≤40 ml/min); d. icu duration before liver transplantation≥48h; e. have received abdominal surgery within one month before liver transplantation or; f. common bile duct jejunostomy (except for children); g. excessive blood transfusion (blood transfusion exceeds 2000ml); h. the donor's icu hospital stay exceeds 5 days; i. positive sputum and blood culture of the donor j. the donor has evidence of lung or bloodstream infection (pulmonary infection is evaluated according to the diagnostic criteria and treatment principles (draft) of invasive lung fungal infection, and bloodstream infection is evaluated according to invasive fungal disease of patients with hematopathy/malignant tumor diagnostic criteria and treatment principles (fifth revised edition) for evaluation) k. 60 years old ≤ age ≤ 65 years old exclusion criteria: 1. have used other investigational drugs or are participating in other clinical trials within 4 weeks before enrollment; 2. currently combined with any kind of fungal infection; 3. allergic to study drugs; 4. joint transplantation; 5. women who are pregnant, preparing to become pregnant or breast-feeding; 6. the investigator thinks that it is not suitable to use the test drug.

Keywords: micafungin invasive mycosis prevention
a dose-response trial using fe 999049 in japanese women undergoing in vitro fertilisation (ivf) / intracytoplasmic sperm injection (icsi) treatment

Conditions: Infertility

Summary: this trial investigates the effects of several doses of fe 999049 in japanese women undergoing ivf/icsi treatment.


Eligibility criteria:
inclusion criteria: * women diagnosed with tubal infertility, unexplained infertility, infertility related to endometriosis stage i/ii or with partners diagnosed with male factor infertility * women eligible for ivf and/or icsi treatment * women aged 20-39 years * women with body mass index (bmi) of 17.5-32.0 kg/m2 exclusion criteria: * women with polycystic ovary syndrome (pcos) associated with anovulation, endometriosis stage iii/iv * women with history of recurrent miscarriage * women with contraindications to controlled ovarian stimulation with gonadotropins * women with three or more controlled ovarian stimulation cycles
risk prediction model of cardiovascular events in patients with schizophrenia

Conditions: Schizophrenia

Summary: schizophrenia is a serious mental illness that has a great impact on social function. studies have evidenced that schizophrenia patients live 10-20 years less than general population.it mainly dues to high cardiovascular risk. how to improve patients' survival rates? at present, there is an objective model to assess cardiovascular risk among schizoprenia patients in england - primrose.but there is a lack of model for schizophrenia patients in china. in order to better guide clinical practice, we are now exploring a domestic cardiovascular risk prediction model to raise people's awareness.

schizophrenia is a common severe mental disorder with high rate of disability, which seriously affects patients' life.it is necessary to take long-term therapy to control symptoms or prevent recurrence. studies have found that schizophrenia patients live on average ten to twenty-five years less than others. the main reason for high rates of mortality and disability is the high risk of cardiovascular events.there are few domestic large-scale studys on the risk of cardiovascular events in schizophrenia, thus they have not formed objective tools to assess cardiovascular risk. if this risk can be objectively assessed and predicted at an early stage, it is expected to reduce the risk of cardiovascular events and thus reduce mortality.at present, there are mature tools for assessing the risk of cardiovascular events in patients, such as framingham, primrose, etc.the latter is the new tool for assessing cardiovascular events in patients with severe mental disorders. this study used a retrospective cohort design to collect the history of hospitalized schizophrenia patients within 2 years, collect relevant informations about cardiovascular events. the investigators validate the primrose model in china and explore the risk prediction model of cardiovascular events in schizophrenia patients.

Eligibility criteria:
inclusion criteria: * patients hospitalized before july 1, 2020；and hospitalized between july 1 2020-june 30, 2022； * meeting the icd-10 diagnostic criteria for "schizophrenia, schizotypy, delusional disorder"or icd-11 diagnostic criteria for "schizophrenia and other primary mental disorders"; * at least 2 doctors in charge of ward make definitive diagnoses; * age ≥18 years old, male and female are not limited. exclusion criteria: * researchers consider patients unsuitable for the study; * past history of cardiovascular disease (fatal and nonfatal cardiovascular events defined as myocardial infarction, angina, coronary heart disease, coronary artery surgery, cerebrovascular accident and transient ischemic attack, peripheral arterial disease or revascularization) prior to antipsychotic therapy ; * use of lipid lowering drugs or antiplatelet drugs, such as aspirin、statins ，prior to antipsychotic therapy.
a randomized controlled trial of students for nutrition and exercise

Conditions: Obesity

Summary: objectives: we conducted a randomized controlled trial (rct) of students for nutrition and exercise (snax), a middle-school-based obesity-prevention intervention combining school-wide environmental changes, multimedia, encouragement to eat healthy school cafeteria foods, and peer-led education and marketing. methods: we randomly selected schools from the los angeles unified school district (lausd) and assigned five to the intervention group and five to a wait-list control group. school records were obtained for number of fruits and vegetables served, students served lunch, and snacks sold per attending student. pre- and post-intervention surveys assessed psychosocial variables among 2,997 seventh-graders (75% of all seventh-graders across schools). hypotheses: for the rct of snax, we hypothesized that snax would lead to increases in the proportion of students served in the cafeteria (because snax markets cafeterias' healthy foods); increased fruit and vegetable servings (because snax increases access to sliced/bite-sized fruits and vegetables); decreased school store snack sales; and greater water consumption. we also hypothesized that snax would lead to more positive attitudes about the cafeteria and water, improve obesity-prevention knowledge, and increase intentions to drink water.


Eligibility criteria:
inclusion criteria: * schools with \>50% nslp-eligible students (a proxy for low-income) and \<900 - seventh-graders exclusion criteria: * schools with \ 900 seventh-graders
acute effect of plyometric exercises on musculotendinous properties

Conditions: Healthy

Summary: preventive and rehabilitation programs include plyometric exercises to promote agility, power, and muscle activation pattern during jumping. these exercises also are known to cause a high mechanical load that increases the risk of a musculoskeletal injury. the knowledge regarding the musculoskeletal damage result from this configuration of exercise can help to elaborate safer and effective training and rehabilitation programs. in this study, the investigators will conduct a clinical trial to determine the acute effect of plyometric exercises on damage caused on different portions of quadriceps and biceps femoral's muscles and tendons of quadriceps, and biceps femoral, and its effects on mechanical properties.

this is a single-arm clinical trial aiming to determine the acute effect of one session of plyometric exercises on quadriceps and biceps femoral musculotendinous properties in healthy individuals. the sample size was determined using g\*power software considering the application of anova: repeated measures, between factors, 90% power, alpha 0.05. data from muscle echo intensity of the rectus femoral by muddle et al. (2019) were considered for this calculation, with an effect size 0.44. a total of 30 individuals was required for this study. the outcomes will include the muscle and tendon quality, and mechanical properties of the tendon. the assessments will be performed at three different moments: before exercise, immediately after, and 48 hours after exercise. the data analysis will be performed per protocol. generalized estimating equations will be used to identify the effects of time followed by bonferroni posthoc. when effects are found, effect sizes will be estimated. missing data will be estimated by statistical analysis.

Eligibility criteria:
inclusion criteria: * who practice physical activity (except jump training); * no previous lower extremity muscle injury at least 6 months before the recruitment; * no previous lower extremity ligament or tendon injury or surgery; * no auditory, vestibular, visual or musculoskeletal injuries or disease that limit the execution of the exercise and assessment protocols; * no hypertension, cardiovascular, or respiratory disease. exclusion criteria: * body mass index greater than 30 kg/m².

Keywords: adult lower extermity plyometric exercise muscle properties
fast-track surgery for perforated peptic ulcers

Conditions: Peptic Ulcer Perforation

Summary: the concept of "enhanced recovery after surgery" has become increasingly popular in elective abdominal surgeries. yet, the role of this concept has not been described in emergency procedures. therefore, this study aimed to investigate the feasibility of fast-track surgery in patients with perforated peptic ulcer.

the study is designed as a randomized, controlled clinical study. the patients with a preoperative diagnosis of perforated peptic ulcer will be recruited for the study. among those, the patients with a definitive diagnosis of perforated peptic ulcer confirmed by surgical exploration will be included. the patients will be randomized according to their protocol number given automatically by the registration system of the hospital during admission. the patients who have an odd protocol number will have conventional surgical protocol, and those who have an even protocol number will have fast-track surgery protocol. the conventional surgical protocol for perforated peptic ulcers is composed of regular general anesthesia, postoperative pain control by intravenous analgesics, removal of nasogastric tube by the end of 48th postoperative hour, initiation of oral intake after clinical signs of active bowel movement is observed. fast-track surgery protocol, however, is composed of general anesthesia with short-acting agents and the use of regional anesthesia if possible, removal of nasogastric tube during recovery from anesthesia, aggressive pain control, initiation of oral intake by the end of 48th postoperative hour. all of the patients will be scheduled for control gastroscopy in the end of six weeks after surgery. primary end-point is the morbidity and mortality rate. secondary end-points are length of hospital stay, readmission rate, endoscopic findings in control gastroscopy.

Eligibility criteria:
inclusion criteria: * perforated peptic ulcer located in the stomach or the duodenum exclusion criteria: * the patients who refuse to join the study or to sign the informed consent form * the patients who are unable to understand and sign the informed consent form * age younger than 18 * the patients with a possibility of having trouble in communicating with or reaching the investigators during the first 6 weeks after surgery * the patients who are considered as asa class 4 * shock on admission * the patients who have serious negative factors for wound healing such as steroid usage, autoimmune diseases * pregnant * previous upper abdominal surgery * the patients who are found to have a pathology other than perforated peptic ulcer during surgical exploration * the patients who are found to have malignant ulcer during surgery or in postoperative period * concomitant bleeding peptic ulcers * peptic ulcer perforations with a diameter greater than 5 mm, which are not suitable for simple repair techniques * multiple perforated peptic ulcers
palatability and tolerability of deferasirox taken with meals, with different liquids or crushed and added to food

Conditions: Transfusional Hemosiderosis

Summary: this single-arm, open-label, multi-center study enrolled 65 patients from approximately 20 centers. all patients who met the study criteria and were taking, beginning or resuming treatment with deferasirox were allowed. the study will began with a one month run-in phase, where all patients were instructed to take deferasirox according to their physician's prescribing information.

following the run-in phase, patients entered a three month, assessment phase. during the assessment phase, patients were given five general options for taking deferasirox including with or without meals, crushed and added to a soft food or mixed in a liquid of choice.

Eligibility criteria:
inclusion criteria: * male or female patients with thalassemia major, sickle cell disease (scd), low or intermediate 1 (int 1) risk myelodysplastic syndrome (mds) or other anemias and transfusional hemosiderosis. * patients who were on, starting, or resuming treatment with exjade. * patients who were \>2 years (i.e., 2 years of age or older). exclusion criteria: * serum creatinine above the upper limit of normal (uln) for age. * alanine aminotransferase (alt) \>2.5 times the uln.-high risk intermediate-2 or high risk mds or acute leukemia.

Keywords: exjade deferasirox palatability tolerability food iron overload serum iron overload due to transfusions
crossing the divide: piloting integrated care to reduce amputations among rural patients with diabetic foot ulcers

Conditions: Diabetic Foot; Diabetic Ulcer of Left Foot; Diabetic Ulcer of Right Foot; Amputation

Summary: this project directly addresses the escalating national rate of major (above-ankle) amputations due to diabetic foot ulcers; it focuses on rural patients, who face 37% higher odds of major amputation compared to their urban counterparts. the project pilots the first integrated care model adapted to rural settings, an approach that has reduced major amputations in urban settings by approximately 40%. pilot data will be used to improve recruitment and retention strategies and provide preliminary evidence of efficacy needed to conduct a robust, statewide efficacy trial.


Eligibility criteria:
inclusion criteria: * healthcare worker inclusion criteria: * willing to provide informed consent * willing to comply with study procedures * rural providers (primary care physicians at the uw health belleville family medicine clinic, diabetes and wound care specialists at sauk prairie healthcare diabetes and wound care clinic) and schedulers placing referrals. * employed at a participating clinic * for rural providers, confirm understanding that they will retain clinical discretion to deviate from the integrated care model if they think it would best serve the patient. * available for the duration of the study * patient inclusion criteria: * able and willing to provide informed consent. * willing to comply with study procedures and be available for the duration of the study. * 18 years of age and older. * patient with either type 1 or type 2 diabetes at a participating rural clinic. * develops diabetic foot ulcer during enrollment period. exclusion criteria: * healthcare worker exclusion criteria: * insufficient overlap in work schedules between rural providers and scheduler based on clinic manager determination. * patient exclusion criteria: * receiving palliative care such that referral to urban centers for aggressive limb salvage would be inappropriate, as assessed by patient rural provider * insurance does not cover referral to the university of wisconsin's specialty clinics * not suitable for study participation due to other reasons at the discretion of the investigators.

Keywords: multidisciplinary care integrated care rural disparities recruitment retention