Kornimate/medical-research-clean huggingface dataset:
effects of non-invasive ventilation on respiratory mechanics and nrd in patients with stable copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is a chronic respiratory disease characterized by persistent respiratory symptoms and airflow limitation. pervasive dynamic pulmonary hyperinflation (dph) and intrinsic positive end-expiratory pressure (peepi) can increase inspiratory threshold load and respiratory effort, leading to abnormal changes in respiratory mechanics and neural respiratory drive (nrd). non-invasive positive pressure ventilation (nppv) is not only widely used in respiratory failure, but also is one of the important lung rehabilitation strategies. several studies have reported that the use of biphasic positive airway pressure (bipap) mode for nppv can improve ventilation, reduce nrd, improve nrd coupling, significantly reduce inspiratory muscle load and relieve symptoms. however, relatively few studies are reported that the nppv is used in copd patients without non-respiratory failure. therefore, we suppose that for stable copd patients without respiratory failure, early intervention with nppv may reduce dph, eliminate the adverse effects of peepi, reduce the respiratory muscle load, improve the respiratory physiological characteristics, and delay the progression of the disease. therefore, the purpose of this study is to observe the influence of different levels of bipap ventilation on respiratory mechanics and nrd in patients with stable copd, and to explore whether bipap ventilation can be used as a pulmonary rehabilitation method for early intervention of copd and provide a theoretical basis for subsequent clinical trials.

the patients with copd will be admitted in one intervention groups. before using bipap ventilation, we will measure the relevant parameters of lung volume, respiratory flow, diaphragm electromyogram, neural respiratory drive mechanical and other baseline index. then incremental pressure support will be applied to investigate the effects of different levels of bipap ventilation on respiratory mechanics and neural respiratory drive.

Eligibility criteria:
inclusion criteria: * patients with pulmonary function test of forced expiratory volume at one second (fev1)/forced vital capacity(fvc) \< 70% after inhalation of bronchial dilation agent. patients in a clinically stable state. exclusion criteria: * patients they had other respiratory diseases, or evidence of pneumothorax or mediastinal emphysema and pacemaker installed. patients with acute cardiovascular event and severe cor pulmonale. patients with poor compliance. an other causes of diaphragmatic dysfunction.

Keywords: chronic obstructive pulmonary disease non-invasive positive pressure ventilation respiratory mechanics neural respiratory drive
use of non-invasive 4d ultrasound clarity system in prostate imrt/rapidarc therapy

Conditions: Prostate Cancer

Summary: a single arm phase ii study of prostate motion for prostate cancer to primarily compare prostate motion between different treatment duration for imrt and vmat.

primarily, this is a single arm phase i study of prostate motion for prostate cancer to primarily compare prostate motion between different treatment duration for imrt and vmat. the radiation therapy is to be delivered using intensity modulated radiotherapy (imrt) or volumetric modulated arc therapy (vmat) with the aid of volumetric image guidance to ensure accuracy and real-time 3d ultrasound images as observational record of the prostate motion. all the recruited patients are prescribed and treated with either vmat or imrt treatment. in order to simulate the behaviour of prostate motion in an imrt scenario, the group of vmat patients will be required to remain in treatment position for an additional 7 minutes depending on techniques used (once a week). in order to assess the level of acceptance of the treatment position, responses to the same comfort survey for the current treatment position (i.e. using leg immobiliser) by a cohort of 60 patients treated in another igrt treatment room will be used as the baseline. in addition, rtt satisfaction questionnaire will also be administered to assess the handling of the new immobilizer. acute toxicity will be measured at preset intervals using ctcae version 3.0 and as will international prostate symptom score (ipss) questionnaire which focuses on urinary symptoms. symptoms or toxicities reported from this study is relevant for patients treated with imrt or vmat with full bladder protocol.

Eligibility criteria:
inclusion criteria: * patient must be able to provide study-specific informed consent prior to study entry. exclusion criteria: * patient who cannot abide to the departmental hydration protocol * prostatectomy cases * acquired immune deficiency syndrome (aids) based upon current cdc definition; note, however, that hiv testing is not required for entry into this protocol. the need to exclude patients with aids from this protocol is necessary because the treatment involved in this protocol requires contact of ultrasound probe to the perineum area. * patient enrolled in other clinical trials
efficacy of buprenorphine for treatment of acute pain

Conditions: Acute Pain

Summary: the purpose of this study is to determine whether sublingual buprenorphine is effective in the treatment of acute pain in adult patients with extremity bone fractures


Eligibility criteria:
inclusion criteria: clinical diagnosis of extremity bone fracture age\>16 years acute pain of score 3 or greater on numerical rating scale exclusion criteria: long term use of opium or opioids/dependence previous administration of analgesic known sensitivity to opioids pregnant women history of medical problems (liver, kidney, heart, hematologic)

Keywords: buprenorphine, acute pain, analgesia
comparison of alternative embryo culture systems

Conditions: Infertility

Summary: this study will compare two alternative embryo culture systems. embryos from each patient will be randomly assigned to one of two systems. one group will be cultured conventionally in oil-covered droplets in dishes. the other group will be assigned to an enclosed system.

qualifying and consenting ivf patients will have approximately half of their developing embryos cultured in droplets covered with oil. the other approximate half of their embryos will be cultured in small enclosed containers. embryo assignments will be at random. regardless of culture system, all embryos will be cultured from the bipronuclear stage to the blastocyst stage in the same (global) media, without the usual refreshing of media on day 3.

Eligibility criteria:
inclusion criteria: * female age 18 to 40, seeking ivf treatment * ability to understand english (to obtain informed consent) * use of an oocyte donor, sperm donor, gestational carrier, and/or genetic testing (with blastocyst biopsy only) are allowed. exclusion criteria: * diminished ovarian reserve as evidenced by either elevated cycle day 3 follicle stimulating hormone (fsh) level (≥10 iu/l) or low antral follicle count (\<8 antral follicles) * fewer than five (5) bipronuclear oocytes * day 3 embryo biopsy for any reason * no minors may enroll

Keywords: in vitro fertilization ivf embryo culture blastocyst transfer
preoperative biliary drainage in malignant biliary obstruction

Conditions: Pancreatic Cancer

Summary: the first alarming symptom of a malignancy of the pancreas or periampullary tumor can be obstructive jaundice (oj). pancreato-duodenectomy (pd) combined with oncological treatment can provide long disease-free survival in resectable cases. the literature regarding the preoperative biliary drainage is controversial. the aim of this multicenter, prospective observational cohort study is to investigate the role of preoperative drainage, and to compare it with surgery alone.


Eligibility criteria:
inclusion criteria: 1. patients ≥ 18 years 2. oj of malignant origin (pancreatic head or periampullary tumor) 3. total bilirubin level ≥ 40 μmol per liter 4. signed written informed consent exclusion criteria: 1. proved metastasis 2. irresectable tumor 3. neo-adjuvant chemotherapy 4. co-existing malignancy 5. pregnancy 6. patients not fit for resection

Keywords: pancreatic cancer biliary drainage pancreato-duodenectomy
virtual hepatic venous pressure gradient (vhvpg) with ct angiography (chess1601)

Conditions: Hypertension, Portal

Summary: this is a prospective, multi-center trial conducted at 1 guangzhou and 2 beijing centers designed to determine the diagnostic performance of virtual hepatic venous pressure gradient (vhvpg) (investigational technology) by anatomic computed tomographic angiography (cta) for non-invasive assessment of the clinically significant portal hypertension (csph) in patients with compensated cirrhosis. direct hepatic venous pressure gradient (hvpg) measurement by means of catheterization of a hepatic vein with a balloon catheter is the gold-standard method to assess the presence of csph, which is defined as hvpg≥10 mmhg.

this is a prospective, multi-center trial conducted at 1 guangzhou (nanfang hospital) and 2 beijing (beijing 302 hospital, beijing shijitan hospital) centers designed to determine the diagnostic performance of vhvpg (investigational technology) by anatomic cta for non-invasive assessment of the csph in patients with compensated cirrhosis. direct hvpg measurement by means of catheterization of a hepatic vein with a balloon catheter is the gold-standard method to assess the presence of csph, which is defined as hvpg≥10 mmhg.

Eligibility criteria:
inclusion criteria: * age \>18 years * patients providing written informed consent * patients with compensated cirrhosis and scheduled to undergo clinically-indicated invasive hvpg measurement by means of catheterization of a hepatic vein with a balloon catheter * has undergone \> 64 multi-detector row cta within 14 days prior to hepatic vein catheterization * no hepatic-portal vein interventional therapy between the cta and hepatic vein catheterization exclusion criteria: * prior transjugular intrahepatic portosystem stent-shunt surgery * prior devascularization operation * has received a liver transplant * patients with known anaphylactic allergy to iodinated contrast * pregnancy or unknown pregnancy status * patient requires an emergent procedure * any active, serious, life-threatening disease * inability to adhere to study procedures

Keywords: clinically significant portal hypertension hepatic venous pressure gradient computed tomographic angiography
to use the combined version of iciq-sf and quality of life scale in mixed urinary incontinence

Conditions: Incontinence, Urge; Incontinence Stress; Quality of Life

Summary: the goal of this observational study is detecting the dominant component of mixed urinary incontinence via a combined version of iciq-sf and quality of life scale. the main question it aims to answer is: 1. which component (urgency or stress) urinary incontinence bothers the patient more?

female patients with mixed urinary incontinence will be given a combined version of iciq-sf and quality of life scale on the first visit. additionally, a bladder diary and 1-hour pad test will be performed on the same visit. after deciding the appropriate treatment, on the 1-month visit (second visit) the same tests will be repeated and scores will be compared.

Eligibility criteria:
inclusion criteria: * female patients above 18 years old with mixed urinary incontinence exclusion criteria: * non-turkish speakers * poor conscious level * immobile patients
construct validity and reliability scues

Conditions: Cerebral Palsy; Upper Extremity Dysfunction

Summary: the aim of the study was to determine construct validity, discriminant validity and intra- and interrater reliability of the selective control of the upper extremity scale (scues).

this study included children diagnosed with unilateral cerebral palsy. children's upper extremity-selective motor controls were evaluated by video recording. manual ability classification system and taylor hand function test were used to determine upper extremity functions

Eligibility criteria:
inclusion criteria: * ages between 3-18 years * diagnosed as cerebral palsy (hemiplegia) exclusion criteria: * participants with an unstable situation regarding their tonus-regulating medications * participants had a botulinum toxin injection within the last 6 months, or any surgical correction within the last year
effect of early morphine administration on the development of acute opioid tolerance during pediatric scoliosis surgery

Conditions: Scoliosis

Summary: the purpose of this study is to examine if morphine administered by bolus before initiating remifentanil by infusion decreases the incidence of acute post-operative opioid tolerance as demonstrated by decreased post - operative morphine consumption in children undergoing scoliosis surgery.

at our institution, a study has recently demonstrated that intraoperative infusion of remifentanil is associated with development of clinically relevant acute opioid tolerance in adolescents undergoing scoliosis surgery. this results in increased morphine consumption which in turn is associated with increased incidence of side effects such as respiratory depression, nausea and vomiting, pruritus, ileus and urinary retention. all of these side effects can result in increased consumption of rescue medications with the additional potential for increased duration of patient stay. any measures that can be introduced to decrease the development of acute opioid tolerance in this patient population would have significant impact on patient morbidity, patient comfort and possibly duration of patient stay.

Eligibility criteria:
inclusion criteria: * unpremedicated * asa physical status 1 or 2 * aged 11 - 18 * scheduled to undergo posterior instrumentation for correction of idiopathic scoliosis exclusion criteria: * chronic opioid use within three months prior to surgery * inability to self-administer morphine using a patient-controlled analgesia (pca) device * elective postoperative ventilation * obesity (\> 130% ideal body weight) * known sensitivity to morphine, remifentanil or any other agent within the standardized protocol * failure to obtain written consent or assent

Keywords: pediatrics scoliosis morphine surgery analgesia
the role of aat on dge after abdominal surgery based on rws

Conditions: Acupuncture, Ear; Gastroparesis

Summary: delayed gastric emptying (dge) after surgery mainly occurs after gastrointestinal surgery a functional gastric emptying disorder, clinically characterized by weak or absent gastric peristalsis, gastric motility disorders, or gastric emptying gastric retention, fullness, nausea and other uncomfortable symptoms caused by delay.this study is based on clinical diagnosis and treatment practice, observing, collecting, and analyzing whipple surgery, pancreatectomy, and gastric cancer perioperative data of subtotal resection surgery, mainly observing the diagnosis and treatment of ear acupoints in whipple surgery, pancreatectomy, and subtotal gastrectomy.the application effect of dge after resection surgery, exploring the diagnosis and treatment of ear acupoints in whipple surgery, pancreatic body and tail resection surgery, and diagnostic value of perioperative related diseases in abdominal surgery such as subtotal gastrectomy, and collection of health records.by comparing and analyzing the ear acupoint information of patients with abdominal tumors, we aim to explore the ear acupoints of the volunteers. the possible relationship between image and resistance specificity and common tumors in the abdominal cavity.


Eligibility criteria:
inclusion criteria: - 1) age range: 40-70 years old (40 ≤ y ≤ 70), gender is not limited. 2) accept abdominal surgeries including whipple's surgery, pancreatectomy, and subtotal gastrectomy. 3) the subjects/guardians are able to understand the purpose of the trial, demonstrate sufficient compliance with the trial protocol, and sign an informed consent form (icf) exclusion criteria: * 1) severe postoperative complications such as heart disease, pulmonary embolism, cerebral infarction, abdominal infection, and abdominal bleeding; 2) patients with organic changes such as adhesions and obstructions indicated by imaging examinations such as gastrointestinal imaging; 3) the patient has damage, redness, bleeding, infection, and other conditions in both ears that are not suitable for ear acupuncture treatment. inclusion and exclusion criteria for the health group inclusion criteria: 1. age range: 40-70 years old (40 ≤ y ≤ 70), gender is not limited. 2. no history of abdominal surgery or tumor, and no significant abnormalities were found through abdominal imaging examination. 3. the subjects/guardians are able to understand the purpose of the trial, demonstrate sufficient compliance with the trial protocol, and sign an informed consent form (icf). exclusion criteria: 1. symptoms of digestive discomfort such as diarrhea, constipation, and vomiting have been present for the past 30 days. 2. the patient has conditions such as damage, redness, bleeding, and infection in both ears that affect the assessment of ear acupoint information.
odsh + ice chemotherapy in pediatric solid tumors

Conditions: Recurrent Solid Tumor; Refractory Solid Tumor; Sarcoma; Wilms' Tumor; Neuroblastoma

Summary: this study will be with pediatric patients who have refractory/recurrent solid tumors. they will receive standard chemotherapy (ice) and we are investigating if the addition of a new drug, odsh, will help to increase the time of their platelet recovery after ice chemotherapy.the purpose of this study is to evaluate the safety and tolerability of odsh in pediatric patients receiving "ice" chemotherapy.


Eligibility criteria:
inclusion criteria: * recurrent or refractory solid tumors. this may include, but is not limited to, osteosarcoma, chondrosarcoma, ewing's sarcoma, wilm's tumor, medulloblastoma, neuroblastoma, hepatoblastoma, rhabdomyosarcoma, retinoblastoma, and primitive neuroectodermal tumors. histologic proof malignancy must have been available at the time of initial diagnosis. * age: 1-21 * patients must have received standard first-line chemotherapy or other appropriate standard first line therapy for their malignancy. * patients must have radiologic or histologic evidence of recurrence * patients must have fully recovered from the toxic effects of the prior chemotherapy and must have an anc \>1000/μl and a platelet count \>100,000/μl * performance status \> 60 from lansky (age 1 to 16) or karnofsky (age \> 16) * adequate hepatic and renal function (ast, alt, bilirubin and creatinine \< 2.5 x upper normal limit). * parent or guardian able to provide informed consent and have signed an approved consent form that conforms to federal and institutional guidelines. exclusion criteria: * patients who, in the investigator's opinion, have extensive bone marrow involvement with tumor * presence of significant active infection or uncontrolled bleeding * renal insufficiency, which, in the opinion of the investigator, might adversely affect schedule and dose of therapy ice chemotherapy. patients with creatinine levels ≥2 mg/dl are not eligible * pre-existing liver disease , other than liver metastasis * use of recreational drugs within the prior month * known history of positive hepatitis b surface antigens or hcv antibodies * known history of positive test for hiv antibodies * patients receiving any form of anticoagulant therapy * presence of a known bleeding disorder or coagulation abnormality * treatment with any other investigational agent, or participation in another clinical trial within 28 days prior to study entry * pregnant or breast-feeding patients * patient with childbearing potential not using adequate contraception * hemorrhage risk that requires maintenance of platelet counts at 50,000 or higher. * psychiatric or neurologic conditions that could compromise patient safety or compliance, or interfere with the ability of the patient or family to give proper informed consent.

Keywords: ice odsh platelet recovery recurrent solid tumor
the potential of radiomics to differentiate between malignant and benign bosniak 3 renal cysts.

Conditions: Renal Cyst Complex

Summary: more than 200,000 new cases of renal cancer are diagnosed in the world each year, with more than 63,000 new cases in europe alone. of those, renal cell carcinoma (rcc) is the most common type in adults, making up more than 90% of the cases. deciding on the benign or malignant nature of some rcc on the basis of medical images (ct, mri, us) is an issue, which often leads to unnecessary surgery, morbidity and costs. a categorization for renal cysts was introduced in the late 1980s known as the bosniak classification. the bosniak classification system classifies them into groups that are benign (i and ii) and those that need surgical resection (iii and iv), based on specific imaging features. however, defining the malignancy of category iii lesions still remains a challenge. though bosniak classification for renal cysts is used worldwide and underwent a number of modifications, bosniak iii cysts still have almost a 1:1 chance of being malignant. so the problem is that approximately half of the bosniak category iii cystic lesions prove to be benign after surgery. the proposed project aims to develop a quantitative image analysis (qia) based multifactorial decision support system (mdss) capable of classifying renal cysts with high accuracy into benign or malignant status, thus reducing the amount of unnecessary surgeries performed. using standard-of-care ct images and clinical parameters, the customized dss will then guide experts in planning a safe and effective diagnostic and treatment strategy for all rcc patients.


Eligibility criteria:
inclusion criteria: * patients who underwent contrast-enhanced ct-scan, with radiological findings suggestive of bosniak 3 renal cyst and have available results for pathology analysis of the cyst. exclusion criteria: * ct-scans that are reformatted or secondary.

Keywords: radiomics bosniak classification renal cell carcinoma medical imaging