Kornimate/medical-research-clean huggingface dataset:
sensitivity and specificity of leucocytes subpopulation versus platelet indices in prediction of clinical outcome for candidates with sepsis. a bi-centric observational clinical trial

Conditions: Sepsis

Summary: leucocyte subpopulation and platelet indices analysis can predict clinical outcome


Eligibility criteria:
inclusion criteria: * adult population of both sex, aged 20 or older admitted to the icu with a diagnosis of sepsis were screened for inclusion within 48 h of presentation to the hospital. sepsis was defined as per the sepsis-3 definition, 6 ie, the presence of suspected or documented infection with organ dysfunction determined by an acute increase of sequential organ failure assessment (sofa) score by 2 or more points exclusion criteria: * patient refusal. * history of surgery in the last 7 days from admission. * immunocompromised population ( post-transplantation, steroid use \> 5 mg per day, malignancy, hiv, on chemotherapy). * population with history of thrombocytopenia ( itp, aplastic anemia, drug induced) * history of thrombocytosis ( idiopathic thrombocytosis, post-splenectomy) * history of platelet transfusion one week before admission. * bone marrow transplanted population . * chronic liver and kidney disease. * von-willebrand disease. * patients on antiplatelet therapy ( aspirin, clopidogrel). * thrombocytopenic population ( itp, ttp,hellp) . * myelodysplastic or proliferative patients. * blood dyscarsiasis * obestetric parturients.
early warning and classification model for acute non-traumatic chest pain

Conditions: Chest Pain

Summary: acute non-traumatic chest pain is one of the common causes of presentation in emergency patients, but the causes of acute non-traumatic chest pain are complex, the severity of the condition varies greatly, and the specificity of symptoms is not high. machine learning and intelligent auxiliary models can greatly shorten the time of clinical decision-making, and improve the accuracy of etiological diagnosis in patients with chest pain, reduce the rate of misdiagnosis and missed diagnosis, and provide a clear direction for further treatment.

prospective observational studies used outpatient and follow-up information to construct an auxiliary early warning model of acute non-traumatic chest pain based on federated learning, and optimized the accuracy of early warning models through retrospective and prospective studies of large cohort data, and established an efficient and stable early warning and classification model for acute non-traumatic chest pain.

Eligibility criteria:
inclusion criteria: 1. older than 18 years old; 2. provided written informed consent; 3. outpatient visits in the pilot hospitals from june 2022 to december 2022 exclusion criteria: 1. did not provide written informed consent and were unwilling to be followed up; 2. traumatic chest pain; 3. systemic pain caused by malignant tumors or rheumatic diseases involving the chest; 4. transferred patients; 5. sudden death or death during hospital treatment; 6. women who are known to be pregnant or lactating; 7. have participated in other clinical trials within 3 months before enrolling in this trial or are currently participating in other clinical trials the lender; 8. according to the investigator's judgment, the patient was unable to complete the study or comply with the requirements of the study; 9. patients were lost to follow-up.
pandemia and exercise in turkey in university students of turkey

Conditions: Sedentary Behavior; Covid19

Summary: the aim of this study is to determine to what extent university students' physical activities are affected by staying at home during the pandemia.

the aim of our study is to determine to what extent university students' physical activities are affected by staying at home during the pandemia considering that they spend hours working by a computer. the state of physical inactivities will be questioned by an online survey for inernational physical activity questionnaire (short form). then average energy expenditure following stepping and/or exercise will be asked from health application of mobile phones.

Eligibility criteria:
inclusion criteria: * being a university student * having sufficient device infrastructure (cell phone or computer) to access the electronic survey exclusion criteria: * entering incorrect numbers for answers * those who have a disease / disability that prevents them from walking and exercising
the impact of bundled payments on quality and cost of care

Conditions: Osteoarthritis; Chronic Obstructive Pulmonary Disease; Pneumonia

Summary: bundled payment is a new payment reform that encourages health care providers to improve quality and contain costs of care. these arrangements are being rapidly expanded across the country, but evidence about their impact are lacking. this study will use medicare claims data to evaluate the effect of participation in a large medicare bundled payment program on the quality and costs of care for common medical and surgical conditions.

the overall objective is to examine the effects of the bundled payments for care improvement (bpci) model 2 on the quality and costs of care for conditions related to seven of the ten medicare severity disease-related groups (ms-drgs) most commonly selected by program participation. five of these are surgical (major joint replacement of the lower extremity; double joint replacement of the lower extremity; revision of the hip or knee, hip and femur procedures except major joint; lower extremity and humerus procedure except hip, foot, and femur) and two are medical (simple pneumonia and respiratory infections; chronic obstructive pulmonary disease, bronchitis/asthma). these ms-drgs represent two larger service lines: orthopedics and pulmonary. for each of these seven ms-drgs, the team will first describe characteristics of provider organizations participating in bundled payment arrangements, including geographic characteristics and clinical volume. we will subsequently empirically test the effect of bundled payment arrangements on quality outcomes and costs of care for these conditions. additionally, the team will examine any spillover effects that occur within the service lines that contain these seven ms-drgs.

Eligibility criteria:
inclusion criteria: * provider organizations that participate in model 2 of the bpci program, accept bundled payment for the ten most common ms-drgs, and have at least ten or greater episodes in each of the ms-drgs. exclusion criteria: * provider organizations who participated in the bpci program, but do not meet inclusion criteria will be excluded.
inhaled no for the treatment of viral pneumonia in adults

Conditions: Viral Pneumonia; Nitric Oxide; Respiratory Disease; Pneumonia, Viral; Inhaled Nitric Oxide; Covid19; SARS-CoV Infection

Summary: the purpose of this multi center, open label, randomized, study is to obtain information on the safety and efficacy of 150 ppm nitric oxide given in addition to the standard of care of patients with viral pneumonia


Eligibility criteria:
inclusion criteria: * patients (male and female) admitted to the hospital for clinical diagnosis of viral pneumonia including covid-19 patients that have a positive nasal swab. * age 18 to 80 years * female subjects must be willing to use medically acceptable contraception from screening to day 30 (acceptable forms of contraception: abstinence, hormonal birth control, intrauterine device, or barrier method plus a spermicidal agent). * ability to understand and comply with study requirements. * signed informed consent by subject exclusion criteria: * patients with pneumonia with two or more of the following: 1. wbc of more than 15,000 2. lobar pneumonia 3. pleural effusion * patients who are treated with or require high flow nasal cannula, cpap, intubation, mechanical ventilation, or tracheostomy * breastfeeding or pregnancy as evidenced by a positive pregnancy test. * subjects diagnosed with immunodeficiency, with history of congestive or unstable heart disease, left ventricular dysfunction (lvef \<40%) or myocardial damage, severe pulmonary hypertension and/or unstable hypertension * use of an investigational drug during the last 30 days prior enrollment * methemoglobin level \>3% at screening * patients on chronic (over two weeks of treatment) systemic steroids (any formulation, excluding dexamethasone or prednisone) within 30 days prior to enrollment. * history of daily, continuous oxygen supplementation * patients with bmi greater than or equal to 40 * patients with clinically significant anemia, e.g., hb \<10.0 and/or thrombocytopenia, e.g., platelets \<75. * smokers who are unwilling to refrain from smoking during hospitalization * presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the subject or the quality of the data, e.g., known or suspected thalassemia, sickle cell disease or other diseases associated with poor oxygen carrying capacity. * the subject is identified by the investigator as being unable or unwilling to perform study procedures.

Keywords: inhaled nitric oxide ino virus respiratory disease viral pneumonia covid-19 sars-cov-2
evolution of molecular biomarkers in acute heart failure induced by shock

Conditions: Acute Heart Failure; Shock

Summary: the relationship between shock, ischemia and reperfusion (i/r) injury, hemodynamic instability, systemic inflammatory response syndrome and multiorgan failure has been extensively investigated, but there is no consensus on the trigger mechanisms of tissue injury at the molecular level. current therapies are targeted to reduce symptoms of shock and multiorgan damage but they are unable to act at the "beginning of the cascade", because of the lack of a model explaining the molecular basis of shock induced tissue injury and ensuing organ damage. the present observational study is aimed at identifying the molecular triggers of acute heart failure (hf) induced by shock and to identify inflammatory mediators and markers that are activated in shock, with a particular emphasis on the role of uncontrolled proteolytic activity.


Eligibility criteria:
inclusion criteria: * for patients in septic shock, severity: sofa score \> 5 * for patients in cardiogenic shock, severity: sofa score \> 5 * first blood sample available within 16 hours from admission to the icu. * only community medical acquired septic shock. we include patients with shock symptoms and shock diagnosis occurring within the first 48 hours from hospital admission * informed consent available exclusion criteria: * risk of rapidly fatal illness and death within 24 hours * patients already enrolled in other interventional studies * n \> 4 units of red blood cells transfused * patients treated with plasma or whole blood * active hematological malignancy * metastatic cancer * immunodepression, including transplant patients: hiv+, constitutive immune system deficiency, immunosuppressive therapy, systemic corticosteroids (aerosols allowed) * patients with pre-existing end stage renal disease needing renal replacement therapy (rrt). the introduction of continuous veno-venous hemofiltration (cvvh), from the day of admission onward is allowed. * cardiac surgery patients * cirrhosis child c

Keywords: shock heart failure inflammation biomarkers cardiovascular instability metabolic pathways proteolysis
evaluating the effects of kombucha as a hyperglycemic therapeutic agent within diabetic human subjects

Conditions: Diabetes Mellitus

Summary: this study's primary objective is to determine the ability of kombucha to impact blood sugar levels in patients with diabetes mellitus type ii. the secondary objective is to determine the ability of kombucha to impact blood pressure, and quality of life measures as measured by uniform questionnaire that includes: gut health, colds, infections, headaches, sleep, anxiety (gad2), depression (phq2), skin health.


Eligibility criteria:
inclusion criteria: 1. s/he is above the age of 18 2. s/he has the ability to read, speak and write english 3. s/he has telephone access 4. s/he is diabetic and willing to check blood sugar levels every day 5. hb a1c \>7% 6. possesses a glucometer exclusion criteria: 1. allergy to kombucha ingredients 2. drinks kombucha regularly (\>3time per week)
efficacy of fluoroscopic guided atlantoaxial joint injection on head and neck pain and sleep quality in ra patients

Conditions: Pain, Head; Sleep Disturbance

Summary: efficacy of intra-articular steroid injection for inflamed atlantoaxial joint in patients with rheumatoid arthritis inclusion criteria patients with rheumatoid arthritis with mri findings of atlantoaxial joint inflammation and failure of resolution after 2 weeks systemic steroid administration exclusion criteria coagulopathy, allergy to contrast material, pregnancy interventional group (as) group, received intra-articular steroid injection for atlantoaxial joint. , in addition to methotrexate and chloroquine 400 mg per day.

efficacy of intra-articular steroid injection for inflamed atlantoaxial joint on sleep quality and head and neck pain in patients with rheumatoid arthritis inclusion criteria patients with rheumatoid arthritis with mri findings of atlantoaxial joint inflammation and failure of resolution after 2 weeks systemic steroid administration interventional group (as) group, received intra-articular steroid injection for atlantoaxial joint. , in addition to methotrexate and chloroquine 400 mg per day.

Eligibility criteria:
inclusion criteria: * patients with rheumatoid arthritis with mri findings of atlantoaxial joint inflammation and failure of resolution after 2 weeks systemic steroid administration exclusion criteria: * coagulopathy, allergy to contrast material, pregnancy
palliation dysphagia cancer oesophagus stent+brachytherapy versus brachytherapy only

Conditions: Esophageal Neoplasm

Summary: we wish to improve the swallowing function of patients with advanced cancer of the oesophagus, by carrying out a randomised clinical study in which we compare primary stenting followed by brachytherapy in the stent, 8 g x 3 with standard brachytherapy 8 gy x 3. the aim of the study is to investigate whether patients who receive a stent followed by brachytherapy have a better swallowing function without more pain at week +2,compared to patients who receive brachytherapy alone.


Eligibility criteria:
inclusion criteria: patients must fulfill all the following criteria: 1. histologically or cytologically verified carcinoma of the oesophagus 2. reduced ability to swallow solid food, minimum grade 1 (see page 16) 3. age ≥ 18 years 4. ability to understand and answer (with or without help) the study questionnaires 5. written informed consent received 6. a completed questionnaire received from the patient 7. one of the following criteria must be fulfilled: 1. advanced disease and who performance status ≥2 2. advanced disease and who performance status 0-1 and other therapy excluded due to medical condition 3. advanced disease and who performance status 0-1 and patient's preference 4. local disease and who performance status ≥2 and other therapy excluded due to medical condition 5. local disease and who performance status ≥2 and patient's preference exclusion criteria: 1. oesophageal stent already inserted 2. endoscopic procedures not tolerated 3. cannot have (additional) radiation therapy 4. tumour location not suited for stent or brachytherapy (the upper 3 cm of oesophagus or major component in the cardia)

Keywords: palliation cancer oesophagus stent brachytherapy randomized
pf-06651600 for the treatment of alopecia areata

Conditions: Alopecia Areata

Summary: this is a global phase 2b/3 study to evaluate the safety and effectiveness of an investigational study drug (called pf-06651600) in adults and adolescents (12 years and older) who have 50% or greater scalp hair loss. the study is placebo-controlled, meaning that some patients entering the study will not receive active study drug but will receive tablets with no active ingredients (a placebo). this is a dose-ranging study, investigating 5 different dosing regimens. it will be double-blinded, meaning that the sponsor, the study doctors, the staff, and the patients will not know whether a patient is on active study drug (or the dose) or placebo.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of alopecia areata with no other cause of hair loss * ≥50% hair loss of the scalp, including alopecia totalis and alopecia universalis, without evidence of terminal hair regrowth within 6 months * current episode of hair loss ≤10 years exclusion criteria: * other types of alopecia or other diseases that can cause hair loss * other scalp diseases that could interfere with assessment of hair loss/regrowth * subjects with shaved heads must not enter the study until hair has grown back \& is considered stable by the investigator * any previous use of any janus kinase (jak) inhibitor

Keywords: alopecia alopecia totalis alopecia universalis patchy hair loss diffuse hair loss hair loss hair disease pf-06651600 ritlecitinib
non-nutritive sucking and swaddling for pain relief in term neonates: randomised controlled trial

Conditions: Pain

Summary: non pharmacological approaches are important in pain control in neonates, specially in term healthy neonates. non-nutritive sucking and swaddling are considered effective strategies for pain control in these population, but the effect in their association are not clear until now. the hypothesis of the study is that association between non-nutritive sucking and swaddling reduces pain scores resulting from venepuncture compared to non-nutritive sucking alone.


Eligibility criteria:
inclusion criteria: * term healthy neonates exclusion criteria: * nicu admission

Keywords: pain, neonate, nursing care
exploratory study to evaluate the efficacy and safety of cd07223 gel in subjects with acne

Conditions: Acne

Summary: the purpose of the study is to evaluate the efficacy of cd07223 1.5% gel and 0.5% gel in reducing inflammatory, non-inflammatory, and total acne lesion counts after 6 weeks of twice daily applications. the study will also evaluate the safety of the study products using tolerance and adverse event data.


Eligibility criteria:
inclusion criteria: * subject has a clinical diagnosis of acne vulgaris with facial involvement * the subject has at least 15 inflammatory lesions and 25 non-inflammatory lesions (excluding the nose) but no more than 2 nodules on the face exclusion criteria: * subject has a severe acne form or secondary acne form * the number of inflammatory or non-inflammatory lesions on one half-face is greater than twice the number on the other half-face * the subject has a known allergy or sensitivity to any of the components of the study products * subject is not willing to respect wash-out periods for topical and/or systemic treatments
role of supermicrosurgical lva for lower limb lymphedema

Conditions: Lymphedema

Summary: vascularized lymph node flap transfer (vlnt) was believed to be the treatment of choice for moderate-to-severe lymphedema. recent publications have supported the use of supermicrosurgical lymphaticovenous anastomosis (lva) for treating severe lymphedema. this study hypothesizes whether lva can be performed on post-vlnt patients seeking further improvement.


Eligibility criteria:
inclusion criteria: * from november 2014 to january 2019 * lower limb lymphedema patients exclusion criteria: * patients who have had previous lva, liposuction, or excisional therapy such as the charles procedure were excluded.
application of health education path of traditional chinese medicine nursin

Conditions: Acute Myeloid Leukemia

Summary: to explore the effect of traditional chinese medicine (tcm) health education standard path on the treatment of patients with acute myeloid leukemia (aml). a total of 60 patients with acute myeloid leukemia in shijiazhuang ping an hospital were selected and divided into control group (n=30) and observation group (n=30) according to the time of admission. both groups received the same chemotherapy, the control group received routine nursing, and the observation group received tcm health education standard path intervention. the scores of self-rating anxiety scale (sas), self-rating depression scale (sds), spitzer quality of life index (qli), awareness of tcm health education standard path content and nursing satisfaction were compared between the two groups.


Eligibility criteria:
inclusion criteria: * patients admitted to the hospital for the first time during the observation period * patients who met the diagnostic criteria for aml * patients with stable disease, clear consciousness, fluent speech, and normal communication * patients who volunteered to participate in the research exclusion criteria: * patients who were repeatedly admitted to hospital during the investigation period * patients with hospitalization time ≤3 days * patients whose condition changed after admission and could not continue to cooperate with the investigation * patients who asked to withdraw during the observation period.

Keywords: acute myeloid leukemia health education traditional chinese medicine nursing
prevention of female genital schistosomiasis (fgs) in rural high-endemic south africa

Conditions: Uro-genital Schistosomiasis

Summary: schistosomiasis is a poverty-related water-transmitted parasitic disease affecting more that 200 million people world wide. infection with schistosoma haematobium may cause female genital schistosomiasis (fgs) with pathological lesions in the female genital tract, especially the cervix. findings indicate that fgs is a hitherto under-diagnosed illness of young women in endemic poor tropical countries, deserving further attention. a cross-sectional study from zimbabwe indicated that the pathologic genital lesions were unchanged two years after praziquantel treatment in adult women whereas in those who had been treated with praziquantel in childhood the prevalence of genital lesions was significantly lower. furthermore, a higher prevalence of hiv was detected in women with fgs compared to those without. the proposed project aims at achieving a better understanding of how annual distribution of praziquantel to pre- and post-pubertal schoolgirls may prevent fgs. this information can be of use in current schistosomiasis control programs in the near term resulting in improved strategies for treatment. preventing or reducing the risk of fgs and genital lesions will lead to improved reproductive health among in women living in schistosomiasis endemic areas. project goal: contribute to a reduction of the global burden of female genital schistosomiasis (fgs) through improved knowledge about the prevention of gynecological lesions and through improved diagnosis of fgs.

provide a more extensive description, if desired. avoid duplication of information to be recorded elsewhere, such as eligibility criteria or outcome measures

Eligibility criteria:
inclusion criteria: * females in schistosoma haematobium endemic areas exclusion criteria: * boys * pregnancy * allergic to praziquantel * severe disease

Keywords: uro-genital schistosomiasis female south africa rural sexually transmitted diseases