Kornimate/medical-research-clean huggingface dataset:
"impact of kangaroo mother care plus massage therapy on growth of preterm low birth weight infants at discharge"

Conditions: Weight Gain

Summary: kangaroo mother care plus massage therapy will lead to improved growth of preterm low birth weight infants at discharge.

primary phase of the transition from the fetal to post-natal period is the most important, vulnerable and stressful phase in human life. hence, care methods that facilitate better adaptation of neonates with early post¬natal environment have an important role in growth of newborns. attachment is a unique relationship between the parents and their infants that begins during pregnancy when fetus grows in uterus and continues to the postnatal period with the relationship of mother and baby. this reciprocal parent-infant relationship is an essential element of the attachment process that helps relaxation of both mother and the infant. kangaroo mother care has facilitated infant growth and decreased morbidities and hospital stay. adding massage therapy may potentiate the kangaroo mother care benefits and better growth in preterm low birth weight infants admitted in neonatal intensive care unit. however, there is a very few published studies from bangladesh regarding this. the objective of this study is to evaluate whether kangaroo mother care plus massage therapy is associated with better growth of preterm low birth weight infants. this study will be conducted in the department of neonatology in bangabandhu sheikh mujib medical university over a period of eighteen months. after detailed history taking and thorough general and systemic examination the newborn will enter in to intervention or control group after taking informed written consent. randomization will be done by random allocation software (version 2.0 developed by mahmood saghaei, iran). patient will be enrolled according to the inclusion and exclusion criteria. thereafter control group will receive standard kangaroo mother care and intervention group will get massage therapy along with kangaroo mother care, up to discharge both group will be meticulously monitored by the investigator. data will be collected by structured questionnaire and analysis will be done by the statistical package for social sciences (spss), version 25.

Eligibility criteria:
inclusion criteria: * 1. gestational age \<34 weeks. or 2. neonates weighing less than 2000 gm. with any one of the following 1. hemodynamically stable. 2. preterm neonate with up to 2 l/min o2 support by nasal canula or prong. exclusion criteria: * inclusion criteria: 1. gestational age \<34 weeks. or 2. neonates weighing less than 2000 gm. with any one of the following 1. hemodynamically stable. 2. preterm neonate with up to 2 l/min o2 support by nasal canula or prong. exclusion criteria: 1. hemodynamically unstable critically ill neonates. 2. newborn with severe perinatal asphyxia and seizure 3. newborn requiring exchange transfusion. 4. newborn with major congenital and chromosomal abnormalities. 5. newborn with sepsis, ivh, shock, necrotizing enterocolitis. 6. newborn with major surgical illness.
gut microbiota in patients with peripheral arterial disease and chronic limb-threatening ischemia

Conditions: Peripheral Arterial Disease

Summary: microbiota has been associated with risk factors for cardiovascular diseases (hypertension, obesity, dyslipidemia, diabetes mellitus, heart failure). in animal models, the gut microbiota produces pro-inflammatory proteoglycans that increase the extent of myocardial infarction, reduced by treatment with probiotics (lactobacillus). tmao, a blood metabolite directly dependent on the gut microbiota is related to atherosclerotic plaque instability and major adverse cardiovascular events (mace) in humans. recent data demonstrate that blood levels of tmao directly correlate with the risk of major mace and mortality in patients with peripheral arterial disease (pad). the goal of this observational study is to evaluate the association between gut microbiota and tmao serum levels and mace and major adverse limb events (male) in patients with pad and chronic limb threatening ischemia (clti) requiring a procedure of endovascular revascularization. the main questions it aims to answer are: * association between gut microbiota and tmao serum levels and male after lower extremity revascularization. * association between gut microbiota and tmao serum levels and mace after lower extremity revascularization. patients with clti requiring lower extremity endovascular revascularization will undergo stool sampling for determination of gut microbiota and blood sampling for the dosage of circulating tmao before the endovascular procedure. incidence of male and mace will be collected in a 24-months follow-up and will be associated with gut microbiota and tmao serum levels.


Eligibility criteria:
inclusion criteria: * age of at least 18 years * ankle/brachial index (abi) of less than 80 * at least one lower limb stenosis greater than 50% documented by ultrasound color doppler (us) * stage 4 or 5 pad diagnosis according to the rutherford classification * presence of chronic limb-threatening ischemia * indication for ler of the target arterial stenosis exclusion criteria: * acute infections at present or in the previous month * antibiotic treatment in the previous month * primary hyperparathyroidism * revascularization of the lower limb in the previous 3 months * diabetic foot ulcers with signs of active infection or osteomyelitis * organ transplantation * active cancer * liver disease at functional status b or c according to child-pugh * absolute contraindication to antiplatelet therapy * thrombophilia * contraindication to endovascular revascularization

Keywords: microbiota gut microbiota tmao mace male
the impact of thumb carpometacarpal osteoarthritis on general health

Conditions: Thumb Arthritis

Summary: this study is designed to define the impact of thumb arthritis on patient's general health. as a secondary objective, data will be analyzed to determine the effects of medical and musculoskeletal comorbidities on the rating of upper extremity function by the patient.

this study is designed to define the impact of thumb arthritis on patient's general health. as a secondary objective, data will be analyzed to determine the effects of medical and musculoskeletal comorbidities on the rating of upper extremity function by the patient. potential contribution: the data that we intend to gather could further our understanding of the overall health impact of thumb osteoarthritis and allow surgeons to more accurately interpret patient-rated measures of upper extremity function in the presence of comorbidities. osteoarthritis of the thumb carpometacarpal joint is one of the most common sites of arthritic degeneration in the hand. to date, no study has examined this conditions impact on overall health using a validated health measure (e.g. sf-36). additionally, no study has examined the impact of medical and musculoskeletal comorbidities on patient-rated measures of upper extremity function in these patients.

Eligibility criteria:
inclusion criteria: * healthy adults clinically diagnosed with thumb carpometacarpal osteoarthritis. the diagnosis must have been confirmed radiographically prior to consideration for study enrollment. * adults accompanying patients to participating offices will be recruited to be control subjects. they must not be receiving medical or surgical treatment for a hand or wrist complaint. * additionally control subjects must not have been diagnosed with thumb osteoarthritis. exclusion criteria: * subjects must be over 18 years of age and english speaking. * subjects are not to include incarcerated adults or those unable to provide consent for study participation. * patients diagnosed with currently symptomatic hand or wrist pathology outside of the thumb carpometacarpal joint will be excluded. * patient with prior surgery on the affected thumb will be excluded. * pregnant females are excluded from study participation with pregnancy determined by patient self-reporting (standard of care before office radiographs).

Keywords: thumb arthritis impact of thumb arthritis on health
consequences of the covid-19 lockdown on health and well-being of patients with parkinson disease and post-stroke

Conditions: Parkinson Disease; Stroke

Summary: the study aimed at describing the effects of the covid-19 social distancing on function, health and well-being of patients with parkinson's disease or post-stroke, and test the association between the patient activation level and these effects.an anonymous survey was distributed through social media and patient associations.community-living patients with parkinson's disease or post-stroke were invited to answer the survey.

people with chronic diseases like parkinson's disease or post-stroke rely on routine medical and rehabilitative care to maintain daily function and health. these are important aspects of self-management. however, this was challenged by the social distancing due to covid-19, which limited participation in regular routines. the study objectives were: to (1) describe the effects of the covid-19 social distancing on function, health and well-being of patients with parkinson's disease or post-stroke, and (2) test the association between the patient activation level and these effects. community-living patients with parkinson's disease or post-stroke were invited to answer an anonymous survey through social media and patient associations. part 1 included 27 multiple-choice questions regarding current status and changes in function, health, medical care and well-being. part 2 consisted of the patient activation measure, describing people's knowledge, skill, and confidence in managing their own health.

Eligibility criteria:
inclusion criteria: * people diagnosed with parkinson's disease or their caregivers, or people post-stroke or their caregivers * live in the community * if a family member or caregiver completed the survey, we asked them to answer in reference to the patient. exclusion criteria: * diagnosis of covid-19 * hospitalization in the last 3 months.
shanghai diabetic eye study in diabetics

Conditions: Diabetic Eye Diseases; Diabetic Retinopathy

Summary: the purpose of the shanghai diabetic eye study (sdes) was to guide and regulate eye health screening of two hundred thousand people with diabetes in the communities in 16 districts in shanghai, build up the ranks with the general practitioner as the backbone combined, and provide comprehensive, continuous, and dynamic information service to diabetic eye disease health management. we expect to form a "screening, finding, referral, follow-up and health management" diabetic eye disease working mode, integrate medical care and precaution closely, promote the classified management and referral, reduce the prevalence rate of diabetic eye disease, blindness and visual impairment of dr, and improve diabetics consciousness of eye health maintenance. at the same time, we will also improve the device configuration of eye health screening and relevant personnel training mechanism in the community health service centers, thus upgrading the level of eye disease prevention and treatment in shanghai.

community-based cross-sectional samples of the archives management of adults with diabetes aged 35 years and above in 241 community health service centers (chsc) in 16 districts in shanghai, were obtained through proportional sampling (32%). field screening, remote diagnosis, comprehensive assessment, referral, and eye health management of diabetics were the main study processes. field screening mainly included visual acuity assessment, autorefraction examination, and non-mydriatic fundus photography. the designated medical institutions (dmi) of each district are responsible for the remote diagnosis and comprehensive assessment of diabetic eye diseases, especially diabetic retinopathy (dr), based on comprehensive evaluation of eye and general condition through the remote reading system (rrs) and shanghai eye health information service system (sehiss). the staff of chsc urged the referral objects promptly for further diagnosis and treatment in dmi. according to the diagnosis after clinically confirmed, all the study participants will be recommended appropriate eye health management

Eligibility criteria:
inclusion criteria: * the target population included the adults with diabetes aged 35 years and above under archives management, residing in shanghai. exclusion criteria: * \<35 years old; * diabetics should not be able to move freely, clear-thinking and considered possible to cooperatively complete the ophthalmic examinations.

Keywords: diabetic eye diseases diabetic retinopathy
nor-epinephrine versus midodrine/octreotide in patients with hepatorenal syndrome

Conditions: Hepato-Renal Syndrome

Summary: hepatorenal syndrome is a functional renal impairment occurring in cirrhotic patients . it develops secondary to splanchnic arterial vasodilatation which decreases the effective blood volume, activate the renin-angiotensin-aldosterone system, and stimulate of sympathetic nervous system.this study aims to compare the efficacy of nor-epinephrine versus midodrine/ octreotide, together with intravenous albumin on renal functions of patients with hepatorenal acute kidney injury.


Eligibility criteria:
inclusion criteria: both sexes aged 18 years or older having cirrhosis, ascites, and a diagnosis of hrs-aki based on the 2015 international club of ascites (ica) diagnostic criteria exclusion criteria: serum creatinine (scr) \>7 mg/dl hypotension (mean arterial pressure (map) \<70 mm hg) or sepsis. recent treatment with vasopressors. patients with severe cardiovascular disease known allergy to study medications
study to support fetal heart rate and uterine contraction for preterm labor in singleton and multiple pregnancies

Conditions: Pre Term Labor; Multiple Pregnancy

Summary: the purpose of this study is to compare the monica an24 fetal monitor to previously fda approved devices for fetal heart rate and uterine contractions in labor for multiples and pre term labor.

clinical investigation for a non-inferiority/equivalence study that aims to determine the acceptable performance of the monica an24 during the first and when possible the second stages of labor by determining whether the monica an24 fetal heart rate (fhr) and uterine contractions (uc) monitoring device is non-inferior/equivalent to doppler fhr and tocodynamometer uc using direct fetal scalp electrode (fse) fhr and intrauterine pressure catheter (iupc) uc as a reference, either collected simultaneously with the monica and doppler fhr/tocodynamometer uc data, or from previous studies to define the expected accuracy and success rate when comparing monica fhr and uc with doppler fhr and tocodynamometer uc respectively

Eligibility criteria:
inclusion criteria: * she is \>=24weeks 0days but less than 36 completed weeks, with a singleton pregnancy or \>=34weeks 0days with a multiple pregnancy and has been admitted to the labor and delivery unit * she is in the latent phase of spontaneous labor, or has been admitted for induction of labor * she has given her informed consent to participate as a subject * she has none of the exclusion criteria exclusion criteria: * known major fetal malformation or chromosome abnormality * involvement in another clinical trial currently or previously in this pregnancy * medical or obstetric problem that would preclude the use of abdominal electrodes (e.g., skin eruptions, sensitivity to adhesives) * significant medical or obstetric problem that in the investigator's opinion would make the woman incapable of taking part in the study

Keywords: ptl multiples
evaluation of survivorship wellness group program for patients treated at university of california, san francisco (ucsf)

Conditions: Cancer

Summary: interdisciplinary psychological interventions targeting survivorship are not only understudied but face several implementation challenges. for this project, the study team is proposing to analyze these data to report on preliminary pilot outcomes, as well as acceptability and feasibility of the implementation of the survivorship wellness group program, an interdisciplinary wellness and health-behavior change program for survivors of cancer, who have completed treatment at university of california, san francisco and are currently without evidence of active disease.

study objectives: 1. to examine the feasibility and acceptability of implementing an interdisciplinary goal-setting clinical group program focused on domains of physical, psychological, and spiritual wellness for survivors of cancer at university of california, san francisco. 2. to determine preliminary efficacy of the survivorship wellness intervention in regards to: 1. increasing knowledge of and perceived confidence in execution of health behavior changes in domains of physical, emotional, and spiritual wellness for survivors of cancer 2. increasing quality of life 3. reducing symptoms of depression and anxiety 4. increasing physical activity

Eligibility criteria:
inclusion criteria: * english-speaking * treated for any kind of cancer at university of california, san francisco, though finished with active treatments (defined as chemotherapy, radiation, or surgery) at time of enrollment, and without evidence of current active cancer * sufficient cognitive ability to participate in group activities as determined by their attending medical oncologist or surgeon exclusion criteria: * non-english speaking * primary cancer treatment outside of ucsf * currently receiving non-maintenance therapies (chemotherapy or radiation) for active cancer * psychiatric illness that would affect the ability to participate in a group activity

Keywords: quality of life survivorship health behaviors
assessment of an alternative model of follow-up of children and adolescents with type 1 diabetes

Conditions: Type 1 Diabetes Mellitus

Summary: the purpose of the study is to look at the effect of replacing the physician only visit by a transmission of information on the participant's current diabetes management and blood glucose monitoring results followed by a phone contact by the diabetes nurse educator. the study will also measure the effect on diabetes control (hba1c), satisfaction with care, resource utilisation, and costs to the health care system and to the participant. we hypothesize that replacement of the physician-only visit by a virtual visit will not result in worsening of the medical outcomes and that it will result in a reduction in medical resources utilization and costs for families while increasing the satisfaction with care.

improved metabolic control reduces both the onset and progression of diabetes-related complications in adults and adolescents with type 1 diabetes. frequency of contact with the medical care team has been associated with better control. both the american diabetes association and canadian diabetes association recommend regular quarterly visits. however, the increase in case loads and the limited manpower available forces us to look at alternative models of care. a model of care in which medical visits alternate between a face to face multidisciplinary visits and a virtual visit done via fax or e-mail communication and a phone call may be advantageous to both the patient and the medical care team. for the patient and his family, this model would decrease time away from school and work, travel inconveniences and costs. for the medical care team it may decrease time per patient and therefore increase the number of patients served with the same resources.

Eligibility criteria:
inclusion criteria: * children: 17 years of age or less * diagnosis of type 1 diabetes for at least 12 months * currently being followed at the alberta children's hospital diabetes clinic. exclusion criteria: * compromised metabolic control (hba1c \> 10%) * uncontrolled hypo or hyperthyroidism * uncontrolled celiac disease * language or psychosocial barrier preventing the family from completing the study * diabetes duration of less than 1 year * participation in other clinical trials with specified clinic visits.

Keywords: type 1 diabetes telemedicine children
use of artificial intelligence-guided echocardiography to assist cardiovascular patient management

Conditions: Heart Failure; Valve Heart Disease

Summary: heart failure and valvular heart disease are disproportionate problems in rural and remote australia (rra). echocardiography is the best imaging investigation, and essential for management, but access to this essential test shows huge geographic variations, primarily because of dependence on expert acquisition. this trial seeks to demonstrate the effectiveness of artificial intelligence-based echocardiography for triage and management of patients with known or suspected heart disease in rra.

heart failure (hf) and valvular heart disease (vhd) are disproportionate problems in rural and remote australia (rra) relative to the rest of the country, due in part to an ageing rural population and to the frequency of rheumatic heart disease in the aboriginal community. late diagnoses can lead to avoidable hospital admissions and expense to the australian health system. echocardiography is the imaging investigation of choice, and a cornerstone of management, but access to this essential test shows huge geographic variations in australia. the primary reason for this is the dependence of this technique on expert acquisition. artificial intelligence (ai) has now been harnessed to optimise echocardiographic image acquisition, and secure, cloud-based storage enables remote measurement and interpretation. this trial seeks to demonstrate the effectiveness of ai-based echocardiography-guided triage and management of patients with known or suspected heart disease in rra. this study will involve the conduct of a world-first randomised controlled trial of ai-testing and early intervention to detect early stages of hf and vhd, select appropriate management, reduce admissions and preserve functional status and quality of life. the study will be conducted with partipants in rra, aged 40 years and older with at least one hf risk factor and recruited through clinic and community outreach in four sites with the involvement of remote outreach from i) alice springs hospitals, ii) nepean hospital to dubbo hospital and western nsw, iii) princess alexandra hospital to roma, charleville and western queensland, and iv) perth aboriginal communities in partnership with the royal perth hospital and the derbarl yerrigan health service. approximately 1200 individuals at risk for hf and vhd will be screened and followed up. the study will be conducted in partnership with aboriginal community partners.

Eligibility criteria:
inclusion criteria: * age \>45 years * eligible for medicare * exercise intolerance or cardiovascular (cv) risk factors exclusion criteria: * known hf or hvd * situations where cardio-protection is already indicated (eg. known cad) * comorbid conditions with life expectancy \<2 years * inability to provide written informed consent

Keywords: artificial intelligence echocardiography heart failure valve disease