Kornimate/medical-research-clean huggingface dataset:
development and validation of "ready-to-use" inhalable forms of hydroxychloroquine for treatment of covid-19

Conditions: Covid19; Hydroxychloroquine Adverse Reaction

Summary: in this project, we aimed at developing new "ready-to-use" inhalable forms of hcq that can be used directly through nebulization or using dry powder inhalers (dpis). these inhaled forms would allow a simple and direct delivery of the drug (hcq) specifically towards the throat and the lung which are the main sites for the covid-19 viral infection. hence, the drug can be available at higher concentrations in the throat and lungs as compared with the currently used treatment protocols, while minimizing the drug systemic concentrations and its presence in other body organs, and thus enhancing the drug efficacy with significantly limiting its side effects. besides, using inhalable forms can be more convenient to patients suffering from gastrointestinal complications from the disease that can limit the absorption of oral forms. moreover, the proposed inhalable forms are designed in such a way to hide the drug from the immune system (confer stealth characteristics) using fda-approved excipients to minimize/avoid any immune response towards the drug as was noted towards it in its oral form that's used in the treatment protocol of covid-19. in addition, the inhaled formulations will be designed to maintain the overall simplicity and scalability of the preparation which is critical during this urgent pandemic situation. the cost of the final formulation is also taken into consideration since the drug is intended for treatment of thousands or probably millions of patients around the world including countries with limited economic capabilities.


Eligibility criteria:
inclusion criteria: * age ≥ 18 year * laboratory (rt-pcr) positive of sars-cov-2 (moderate cases) * chest ct with pneumonia. * sao2/spo2 ratio \> 93% or pao2/fio2 ratio \> 300 mmhg under the condition in the hospital room. * welling to participate and able to give fully informed consent exclusion criteria: * severe and critical illness. * retinopathy and other retinal diseases. * arrhythmias. * qt ≥ 400 msec * receiving cardiac drugs * severe liver disease. * pregnancy or lactation. * previous treatment of covid-19.

Keywords: covid19 hydroxychloroquine
lactobacillus plantarum 299v in colon surgery

Conditions: Bacterial Translocation; Inflammation; Cell Proliferation

Summary: intestinal pathogenes are often involved in postoperative complications after colon surgery. probiotic bacteria, i e live bacteria which have beneficial effects on the host when ingested, have been shown to reduce bacterial translocation in animal studies. however, in humans studies results have varied. the purpose with this study was to find whether high doses of lactobacillus plantarum 299v affects the potentially pathogenic microflora of the gut, bacterial translocation and cell proliferation in patients undergoing planned colon surgery.


Eligibility criteria:
inclusion criteria: * planned resection of colon for malignant or benign disease * all ages exclusion criteria: * unable to understand instructions and perform preoperative intake of study preparation * rectal surgery * present or past history of endocarditis * congenital or acquired valvular heart disease

Keywords: colorectal surgery probiotics lactobacillus bacterial translocation postoperative complications inflammatory reaction
the effect of saae on vascular endothelial function in pa patients

Conditions: Primary Aldosteronism

Summary: the study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation

after being informed about the study and potential risks,all patients giving written informed consent will undergo a 2-week screening period to determine eligibility for study entry.at week 0,patients who meet the eligibility requirements will be divided into superselective adrenal arterial embolization group or spironolactone therapy group,according to the patient's surgical indications and wishes.

Eligibility criteria:
inclusion criteria: * (1)aged 18-75 years, males and females; * (2)blood pressure ≥ 140/90 mmhg on at least three non-same-day office visits without antihypertensive medication or 24-hour ambulatory blood pressure averaging \>130/80 mmhg throughout the day or averaging \>135/85 mmhg during the day; * (3)primary aldosteronism was diagnosed in accordance with the 2016 international society of endocrinology clinical guidelines after strict drug elution; * (4)contraindications to spironolactone-free administration; * (5)no surgical intention or surgical contraindications, and willing to accept drug treatment or percutaneous superselective adrenal artery embolization; * (6)the anatomy of adrenal arteriography is suitable for selective adrenal artery embolization. exclusion criteria: * (1)secondary hypertension of other causes; * (2)pregnant women or those who have a fertility plan in the next year; * (3)glomerular filtration rate egfr \< 45 ml/min/1.73m\^2; * (4)history of severe contrast allergy; * (5)hyperkalemia; * (6)patients with other serious organic diseases or life expectancy \< 12 months can not tolerate the treatment of super selective adrenal artery embolizatio; * (7)the diameter of adrenal space occupying lesions was more than 2 cm; * (8)a history of myocardial infarction, syncope, cerebral hemorrhage or cerebral infarction within 3 months before the informed consent; * (9)the results of this study will be affected during the period when patients are enrolled or will participate in other clinical studies.

Keywords: primary aldosteronism selective adrenal artery embolization vascular endothelial function
lung recruitment maneuver for predicting fluid responsiveness in children

Conditions: Hypovolemia

Summary: lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. the authors hypothesized that the changes of dynamic variables through lung recruitment maneuver could predict preload responsiveness in pediatric patients with lung protective ventilation


Eligibility criteria:
inclusion criteria: * pediatric patients undergoing general anesthesia under 6 years old exclusion criteria: * arrhythmia * \<30%, ejection fraction * lung disease
wideband tympanometry in otitis media with effusion

Conditions: Otitis Media With Effusion

Summary: the investigators asked the question if they can better estimate the middle ear status in ome that help them to decide between early intervention or longer follow up.

purpose: otitis media with effusion is an important problem in childhood. after proper diagnosis, generally 3 months of follow up has been recommended before surgical tympanostomy tube insertion. if the physician can estimate the status of the middle ear or fluid type better with a non-invasive method, we can suggest an early operation to these patients or decide to follow up more with no intervention. the purpose of the study is to compare the surgically confirmed middle ear effusions with wideband absorbance values and to differentiate them noninvasively before the operation. methods: a total of 123 children that were followed 3 months and treated surgically with the diagnosis of ome were included. eighty-two sex, age-matched children were tested as control with wideband tympanometry. ears were divided into four groups according to findings in the operation: serous, mucoid, adhesive, empty. resonance frequency, 226 hz, 1000 hz compliance, wideband peak pressure, absorbance measurements used for comparison.

Eligibility criteria:
inclusion criteria: * all patients were diagnosed by ear examination, pneumatic otoscopy, and type b tympanogram with 226 hz tympanometry. they were followed for 3 months with proper medication. after 3 months if there was no change with ear examination and 226 hz tympanometry, surgical ventilation tube insertion was offered. exclusion criteria: * the patients with chronic ear diseases, ototoxic drug use, neurologic disease were excluded.
demonstrate noninferiority in efficacy and to assess safety of ct-p13 in patients with active crohn's disease

Conditions: Crohn's Disease

Summary: this study is to assess noninferiority in efficacy and to assess overall safety of ct p13 compared to remicade in patients with active crohn's disease up to week 54.


Eligibility criteria:
inclusion criteria: * male or female patients with active crohn's disease and a crohn's disease activity index score between 220 and 450 points exclusion criteria: * patient who has previously received a biological agent for the treatment of crohn's disease and/or a tumor necrosis factor (tnf)-alpha inhibitor for the treatment of other disease. * patient who has allergies to any of the excipients of infliximab, any other murine and/or human proteins, or patient with a hypersensitivity to immunoglobulin product.
a phase 1, open-label study of teprotumumab in patients with diabetic macular edema (dme)

Conditions: Diabetic Macular Edema

Summary: a phase 1 study to evaluate the safety of teprotumumab in patients with diabetic macular edema.

a phase 1, open-label safety and pharmacodynamic study of rv 001, an insulin-like growth factor-1 receptor (igf-1) antagonist, given by iv infusion in patients with diabetic macular edema (dme).

Eligibility criteria:
inclusion criteria: * diagnosis of diabetes mellitus with hemoglobin a1c \<8.5% * igf 1 in serum \> 106 ng/ml * women of child-bearing potential must have negative pregnancy test and be willing and able to use two different methods of contraception, one of which must be oral contraceptive or depot formulation. males must be surgically sterile or agree to use barrier contraception * clinically significant dme of less than 12 months duration * non-proliferative diabetic retinopathy of moderate severity * best corrected electronic etdrs letter score \ 24 exclusion criteria: * unstable-uncontrolled diabetes as demonstrated by a change in diabetes medication greater than 15% in the previous 60 days. * significant renal disease, myocardial infarction, stroke, transient ischemic attack, acute congestive heart failure * blood pressure \> 180/110 * anti-vascular endothelial growth factor (vegf) treatment within two months prior to enrollment * history of pan retinal photocoagulation within four months prior to enrollment * history of ocular surgery within four months prior to enrollment * history of systemic treatment with corticosteroids within 3 months prior to enrollment

Keywords: diabetic macular edema
the effect of massage on diabetic parameters

Conditions: Diabetes Mellitus, Type 2; Peripheral Neuropathy

Summary: this research aims to investigate the effect of massage on diabetic foot risk, hba1c and physiological parameters in individuals with type 2 diabetes. this randomized controlled experimental design will be carried out in bolu izzet baysal state hospital köroğlu unit internal medicine polyclinic and internal medicine service. according to power analysis, the minimum sample size was determined as 60 people, 30 of which were in the intervention group and 30 in the control group. data collection tools include "peripheral neuropathy sign and symptom score", "ankle-brachial index (abi)", "glycemic control assessment (hba1c)", "physiological parameters (blood pressure, heart rate and oxygen saturation)", "inlow's 60-second diabetic food screen". a total of 24 massage sessions will be applied to the intervention group, 2 times a week during the 12-week working period. participants in the control group will continue their medical treatment protocols and massage will not be applied.


Eligibility criteria:
inclusion criteria: * being between 30-75 years old, * diagnosed with diabetes at least 6 months ago, * absence of irritation, ulceration in the areas where the massage will be applied (hands, feet and legs), * no problem in verbal communication, * being able to speak turkish, * no diagnosis of psychiatric disease, * absence of amputation in the upper and lower extremities, * having hba1c test results in the last 1 week, * not having had covid-19 in the last 6 months * no experience of massage application in the last 1 month * willingness to participate in the research exclusion criteria: * presence of diabetic ulcer and foot wound, * irritation and ulceration in the areas where the massage will be applied (hands, feet and legs), * having problems in verbal communication, * not being able to speak turkish, * having a diagnosis of psychiatric illness.

Keywords: massage glycemic control diabetic foot risk
identification of biomarkers for obstructive sleep apnoea syndrome

Conditions: Obstructive Sleep Apnoea Syndrome

Summary: untreated obstructive sleep apnea syndrome (osas) has long-term complications, namely metabolic imbalances (obesity, dislipidemia, type 2 diabetes mellitus). until now, no molecular markers for this physiopathological connection have been identified. this project aims to determine non-invasive biomarkers that may allow better comprehension of the metabolic consequences of osas, as well as assess the effect of continuous positive airway pressure (cpap) on these metabolic parameters. this project will integrate the clinical, metabolic, genetic/proteomic and biologic systems to further explore the mechanisms behind osas, as well as the effect of the treatment with cpap.


Eligibility criteria:
inclusion criteria: * male * 25-60 years * mild/moderate/severe osas exclusion criteria: * female * other sleep disorders * previous cpap therapy * type 1 diabetes mellitus * familiar dyslipidemia * severe organ pathology * acute disease

Keywords: cpap osas cedoc (centro de estudos de doenças crónicas) fcm (faculdade de ciências médicas) unl (universidade nova de lisboa nova medical school fct (fundação para a ciência e tecnologia)
efficacy and safety of insulin aspart versus glibenclamide in type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in japan. this is a clinical trial to study the efficacy and safety of thrice daily insulin aspart compared to glibenclamide in type 2 diabetic patients.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * diet therapy for at least 12 weeks, or diet therapy and oral hypoglycaemic agent(s) other than su agents for at least 12 weeks * no previous treatment with insulin and/or su agents * hba1c between 7.5% and 10.0% * body mass index (bmi) below 30.0 kg/m2 exclusion criteria: * proliferative retinopathy or maculopathy requiring acute treatment * impaired hepatic function * impaired renal function * cardiac diseases * uncontrolled hypertension * known hypoglycaemia unawareness or recurrent major hypoglycaemia * current treatment with systemic corticosteroids
rehabilitation of cancer survivors in denmark: the effect of a psychosocial rehabilitation course

Conditions: Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms

Summary: this randomized study evaluates the effect of a multi-focused, psychosocial 6-day residential rehabilitation course at a danish rehabilitation centre for cancer survivors. the investigators hypothesize that individuals in the intervention group will experience better psychosocial well-being and more adaptive health behaviour changes as compared to individuals in the control group.

worldwide, the number of cancer survivors is increasing. in the danish population of 5.4 million people, more than 300 000 are cancer survivors. given the range of physical, psychological and social late effects of cancer and its primary treatment many survivors need tailored rehabilitation interventions. this randomized study evaluates the effect of a multi-focused, psychosocial 6-day residential rehabilitation course at the dallund rehabilitation centre in denmark. we hypothesize that individuals in the intervention group will experience better psychosocial well-being and more adaptive health behaviour changes as compared to individuals in the control group.

Eligibility criteria:
inclusion criteria: * diagnosis of breast, colorectal or prostate cancer * completion of primary treatment * ability to participate physically in the activities offered in the intervention exclusion criteria: * acute need for treatment * terminal cancer phase

Keywords: neoplasms rehabilitation intervention quality of life lifestyle
the effect of dairy on bone mass and body composition in 4th-8th grade boys and girls

Conditions: Healthy

Summary: building stronger bones during pubertal growth could reduce lifelong fracture risk. this project is an 18 month dairy intervention study for overweight and healthy weight 4th-8th grade boys and girls. half of the girls will receive dairy products to add to their habitual diet (milk, yogurt, and cheese) to equal three products per day, while the other half will remain on their normal diet. all participants will attend four study visits, each 6 months apart. at these visits height, weight, bone density and geometry, and fat and lean mass will be measured. this study aims to show that meeting calcium requirements by eating dairy products builds bigger, stronger bones, and that this effect may be enhanced in overweight boys and girls. the effect of the dairy intervention on body fat, lean mass, and weight, as well as the mechanisms and predictors of changes in bone mass and size and body composition will also be evaluated.


Eligibility criteria:
inclusion criteria: * males and females in 4th-8th grade * generally healthy * bmi percentile 5-70% for age or \>85% for age * baseline calcium intake less than or equal to 800mg/d exclusion criteria: * history of any illness known to affect bone mass accrual (diabetes, inflammatory bowel disease, childhood malignancy). * a broken bone in the last six months. * consume more than 800 mg calcium/d.

Keywords: bone dairy intervention girls boys calcium bone mineralization peak bone mass bone and bones female male adolescent healthy
thoracic mobility exercises impact in tibio femoral arthritis patients

Conditions: Knee Osteoarthritis (Knee OA)

Summary: the aim of this randomized clinical trial is to find the effect of thoracic mobility exercises on thoracic hyper kyphosis and hamstring flexibility with tibiofemoral arthritis patients on reducing hyper kyphotic posture, knee pain and improving flexibility of hamstring muscles.

tibio femoral arthritis is a painful heterogeneous musculoskeletal condition that comprises of articular cartilage degradation, distortion of joint tissues, depletion in synovial fluid and progression over time. decline in joint rom usually began in fourth decade, more common in women in the age of menopause mostly the age of 45 years or elder. in pakistan prevalence of tibio femoral arthritis is 28.0% in urban population and 25.0% in the rural population, estimated o outstretch 35% by 2030. hamstring muscle are part of superficial posterior anatomical chain in body that form meridians or myofascial chains connected to thoracolumbar fascia via sacro tuberous ligament. knee joint movements are primarily facilitated by the quadriceps and hamstrings, which play a crucial role in ensuring smooth and accurate ambulation. tightness in hamstring put stress on tibio-femoral joint which further reduce its range of motion especially knee extension, joint loading problems, induce compensatory movements, gait limitations, disturbs overall spinal postural alignment, increase thoracic kyphosis, decrease lumbar lordosis, and inducing posterior pelvic tilt. until now most existing studies focus on the impact of thoracic mobility on thoracic spine issues or general posture, with limited research on its secondary effects on lower limb flexibility in 45 to 65 years old tibio femoral arthritic patients. there is still research gap present to identify comprehensive effects of thoracic mobility exercises, on hyper kyphotic postures with tightened hamstrings, complementing tibio femoral arthritis with aging.

Eligibility criteria:
inclusion criteria: * thoracic kyphotic angle \> 40 * asymptomatic (no pain symptoms in) thoracic spine * able to stand independently * less than 70 degree hip flexion angle on active slr, with limited knee extension range more than 20 degree restriction on ake test * bilateral hamstring tightness * visual analogue scale in targeted joint tibiofemoral arthritis \&gt;3 cm * having osteoarthritis in tibio femoral joint, according to kl (grade 2 and 3) * x-rays showing evidence of reduced knee spaced/osteoarthritis symptoms b/l( \>2 year) exclusion criteria: * muscle/tendon injuries of hamstring * spinal injuries, scoliosis, tumors and malignancies * any surgery, infection, skin sensitivity, trauma, fracture and fall * involvement in regular flexibility yoga program * patient with intra articular steroidal therapy with in last 6 months * patient unwilling to comply follow up schedule * patient involvement in another interventional study

Keywords: thoracic hyperkyphosis hamstring flexibility thoracic mobility exercises
comparison of the long gnrh agonist protocol and the flexible gnrh antagonist protocol of ovarian stimulation

Conditions: Infertility

Summary: the purpose of this study is to compare the efficacy of two controlled ovarian stimulation protocols, the gnrh agonist protocol, widely known as the "long" protocol, and the flexible gnrh antagonist protocol, in terms of pregnancy rates and embryological data, in infertile patients receiving ivf treatment.

the formulation of controlled ovarian stimulation protocols is one of the primary reasons for the successful development of ivf. the "long" gnrh agonist protocol, also known as the gold standard, has been widely used with considerable success. more recently, on the other hand, gnrh antagonist provide a new promising approach for endogenous gonadotrophin suppression by blocking the gnrh receptor. there is conflicting data in the literature regarding the relative merits of the two ovarian stimulation protocols. comparison: pregnancy rates and embryological data will by assessed in ivf patients treated with either the "long" gnrh agonist (arvekap) or the flexible gnrh antagonist (ganirelix) protocol.

Eligibility criteria:
inclusion criteria: * age 18-39 years * body mass index 18-29 kg/m2 * menstrual cycle from 24-35 days * normal basal fsh (\<10 iu/ml) * normal basal lh (\<10 iu/ml) * normal basal estradiol (\<80 pg/ml) exclusion criteria: * poor responder patients * polycystic ovaries

Keywords: gnrh antagonist gnrh agonist long protocol flexible