Kornimate/medical-research-clean huggingface dataset:
structured treatment of osteoarthritis of the knee with or without total knee replacement

Conditions: Osteoarthritis of the Knee

Summary: the purpose of this study is to test whether surgical insertion of total knee replacement provides further improvement in quality of life, pain and function in addition to an algorithm for systematic non-surgical treatment consisting of corrective insoles, neuromuscular training, weight loss, patient education and pharmacological treatment with paracetamol, nsaids and pantoprazol in patients with knee oa, collectively called the medic-treatment(medicine exercise diet insoles cognitive). the h1-hypothesis is that surgery with insertion of tkr in addition to the medic-treatment results in a greater increase in quality of life and functional capacity and greater reduction in pain than the medic- treatment alone at the primary endpoint, which is follow-up 12months after the start of the treatment. see statistical analysis plan available under "links" for further description of the study.

knee osteoarthritis (oa) is the degenerative joint disease that most often requires treatment and at the same time the one associated with the greatest social costs. in addition, the disease has many personal costs and is greatly contributing to reduced functionality and autonomy of older adults. it is recommended both nationally and internationally that the treatment of knee oa should include multiple treatment modalities. clinical guidelines recommend that exercise, weight loss and patient education is the first step in treatment and that insoles and pharmacological treatment can be included as a supplement. if this non-surgical treatment is ineffective surgical treatment, especially surgery with insertion of total knee replacement (tkr), may be indicated. there are effects of both non-surgical treatment and tkr, but no studies exist, which examine the effect of surgery with insertion of tkr in addition to the recommended non-surgical treatment of knee oa.

Eligibility criteria:
inclusion criteria: * knee-oa detected by x-ray (kellgren \& lawrence grade 2 or greater) * considered a candidate for tkr by the orthopedic surgeon. * the participant is \> 18 years of age. * the participant can provide relevant and adequate, informed consent. exclusion criteria: * bilateral simultaneous tkr * revision of prior tkr, unicompartmental knee arthroplasty or high tibial osteotomy * rheumatoid arthritis * mean vas \> 60mm on a 0-100mm scale * investigator considers that the mental condition of the participant does not allow participation. * the participant must not be pregnant or plan pregnancy during the study. * inability to comply with the protocol;. * inadequacy in written and spoken danish.

Keywords: osteoarthritis, knee treatment outcome time factors arthroplasty, replacement rehabilitation combined modality therapy middle aged aged aged, 80 and over male female humans analysis of variance
systane clinical experience study

Conditions: Dry Eye Syndrome

Summary: to evaluate the physical effect of systane qid in people that have moderate to severe dry eyes and to establish doctor confidence to prescribe systane.


Eligibility criteria:
inclusion criteria: * moderate to severe dry feeling eyes exclusion criteria: * none

Keywords: dry eye systane moderate to severe dry eye
serum and exhaled breath condensate maldi-ms of lung cancer. (spore)

Conditions: Lung Cancer

Summary: rationale: collecting and storing samples of blood and exhaled breath from patients with cancer and from healthy participants to study in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this research study is collecting and analyzing samples of blood and exhaled breath from patients who have or are at high risk for lung cancer and from healthy participants.

objectives: * to evaluate the ability of proteomic patterns in serum and exhaled breath condensate samples to detect and discriminate lung cancer from healthy and from high-risk individuals. * to correlate proteomic patterns with tumor behavior. outline: this is a multicenter study. blood and exhaled breath condensate samples are collected, whenever possible, at a time medically indicated for other purposes (e.g., work-up, pre-op, surgical procedures). the samples are used to produce genetic material (i.e., dna, rna) and molecular material (i.e., proteins) that will be stored for future studies, including studies that may not be related to lung cancer. future genetic studies related to lung cancer may include studies of protein expression patterns via matrix-assisted laser desorption/ionization time of flight mass spectrometry that may serve as predictive molecular markers of lung cancer. participants complete a 15-minute lung spore database questionnaire at the time of study enrollment to provide information on demographics (e.g., date of birth, address, phone number), medical and smoking history, personal and family history of cancer and cancer treatment, and current medications. medical records are reviewed at the time of study enrollment and then over approximately 5 years to obtain information, including test results, associated with the diagnosis of cancer. participants may also be contacted by phone at a later time to answer questions about their health status.

Eligibility criteria:
disease characteristics: * meets 1 of the following criteria: * normal healthy volunteer * at high risk for lung cancer (e.g., \> 30-pack year history of smoking; chronic obstructive pulmonary disease; or disease-free after surgical resection of lung cancer) * diagnosis of stage i, ii, iiia, iiib, or iv lung cancer * must be willing to allow blood and exhaled breath condensate samples to be stored for genetic testing patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: stage i non-small cell lung cancer stage ii non-small cell lung cancer stage iiia non-small cell lung cancer stage iiib non-small cell lung cancer stage iv non-small cell lung cancer
clinical feature and treatment of microsporidial keratoconjunctivitis

Conditions: Microsporidial Keratoconjunctivitis

Summary: the purpose of this project was to analysis the causes, pathogenesis, diagnostic modalities and treatment outcomes of microsporidial keratoconjunctivitis.

microsporidia comprise a diverse group of obligate spore-forming intracellular eukaryotic pathogens first described in immunocompromised patients. many species of microsporidia are found in aquatic environments, and they are considered as waterborne pathogens.microsporidia are opportunistic pathogens that are reported to cause infections in various organs, including the eyes. the ocular appearance of this infection can manifest as corneal stromal keratitis or a superficial punctate keratoconjunctivitis. in particular, the characteristic feature of microsporidial keratoconjunctivitis is multiple whitish, slightly elevated epithelial lesions in conjunction with acute conjunctivitis. awareness of microsporidial keratoconjunctivitis is increasing, and the number of cases reported is on the rise. this study was a retrospective case series of patients diagnosed as microsporidial keratoconjunctivitis. the purpose of this project was to analysis the causes, pathogenesis, diagnostic modalities and treatment outcomes of microsporidial keratoconjunctivitis

Eligibility criteria:
inclusion criteria: * patients diagnosed as microsporidial keratoconjunctivitis exclusion criteria: * patients diagnosed as bacterial or viral keratoconjunctivitis
patient convenience study- nis relate

Conditions: Atrial Fibrillation

Summary: the aim of this non-interventional study is to describe patient's perception of anticoagulant treatment when using pradaxa® to prevent stroke and systemic embolism while suffering from atrial fibrillation (according to its approved indication in the approved dosages of 110 mg or 150 mg twice daily) in comparison to standard care using vitamin k antagonist (vka).


Eligibility criteria:
inclusion criteria: cohort a: 1. a. written informed consent prior to participation 2. a. female and male patients \>= 18 years of age with a diagnosis of non-valvular atrial fibrillation. 3. a. at least 3 months of continuous vka treatment for stroke prevention prior to baseline assessment. 4. a. patients switched to pradaxa® according summary of product characteristics and physician's discretion. or cohort b: 1. b. written informed consent prior to participation. 2. b. female and male patients \>= 18 years of age newly diagnosed with non-valvular atrial fibrillation and no previous treatment for stroke prevention (no use of any oral anticoagulant (oac) within one year prior to enrolment). 3. b. stroke prevention treatment initiated with pradaxa® or vka according to summary of product characteristics and physician's discretion. exclusion criteria: 1. contraindication to the use of pradaxa® or vka as described in the summary of product characteristics (smpc). 2. patients receiving pradaxa® or vka for any other condition than stroke prevention in atrial fibrillation. 3. current participation in any clinical trial of a drug or device. 4. current participation in an european registry on the use of oral anticoagulation in af.
mindfulness-based meditation to treat stress in unemployed community adults

Conditions: Stress; Inflammation

Summary: the purpose of this study is to determine the effects of a three-day mindfulness meditation retreat (vs. a three-day relaxation retreat) in stressed, unemployed, community adults on brain function, brain structure, and overall health and immunity.

chronic stress has been shown to be a significant risk factor for increased morbidity and mortality. eight-week mindfulness-based meditation programs (mbsr) have been shown to improve participants' health and well-being, including reducing inflammation and slowing the progression of chronic diseases such as hiv. the purpose of this study is to evaluate the potential benefits of a three-day mindfulness-based meditation retreat program (vs. an active rest and relaxation retreat control condition) on a highly stressed, unemployed, community adult population. participants are recruited from the pittsburgh area and are randomly assigned to either the mindfulness-based retreat program or the rest and relaxation retreat program. all participants complete a psychosocial survey, blood work, and a baseline fmri before completing the intervention. participants complete a second fmri immediately following the intervention and then additional blood work and psychosocial surveys at a four month follow-up timepoint. at each fmri appointment, participants will complete neuroimaging tasks (where they will be presented with words, picture, and sounds) that will assess neuroreactivity, regulation responses, and brain volume before and after mindfulness meditation training.

Eligibility criteria:
inclusion criteria: * english-speaking adults between the ages of 24 and 52 years at time of entry * non-pregnant women only * currently unemployed * high levels of self-reported stress * geographically accessible and willing to travel to and attend all study sessions exclusion criteria: * not able to attend scheduled three-day retreat * have regularly (\>1 time per week) practiced a mind-body therapy anytime in the last six months (e.g., meditation, yoga, tai chi) * indicate any major physical health problems in the last six months * have more than 15 alcoholic drinks in the average week * have been diagnosed with a chronic disease (e.g. hiv, diabetes, arthritis) * use medications affecting cardiovascular or endocrine function * are left-handed * have metal in their bodies (including pacemakers and permanent piercings (e.g., bellyrings, but not dental fillings)) * indicate regular use of psychotropic medication or psychotherapy in the last six months * cognitive impairment as indicated by a score lower than 23 on the mini-mental state examination * demonstrate low levels of stress due to unemployment * smokers * indicate use of recreational drugs in the past month * indicate feeling claustrophobic in confined spaces, such as an fmri scanner * weigh over 350 lbs * have any neurological disorders * indicate any use of doctor prescribed cholesterol lowering medications (e.g., statins) * currently employed * not currently looking for a job

Keywords: mbsr mindfulness stress
transcutaneous posterior tibial nerve stimulation for treatment of chronic anal fissure

Conditions: Chronic Anal Fissure

Summary: lateral internal sphinterotomy (lis) is the gold standard against which all treatments are compared with a healing rate over 92%. however, the most serious complication of this procedure is anal incontinence. to overcome these problems, continued efforts are being tried to find less invasive treatments modalities for anal fissure that is as effective as surgical therapy with lower morbidity.

sacral nerve stimulation has been recently tried for management of chronic anal fissure with promising results. however, the technique described is invasive with the need for surgically implantable expensive stimulator electrodes. the aim of this study was to evaluate the efficacy of posterior tibial nerve stimulation (ptn) by transcutaneous electrical nerve stimulation (tens) and to compare it to the conventional lis. this non-invasive technique has been proved to be of acceptable results in treatment of fecal incontinence and urinary incontinence.

Eligibility criteria:
inclusion criteria: * consecutive symptomatic adults affected by chronic anal fissure were enrolled in the study. exclusion criteria: 1. patients younger than 18 years; 2. patients with laterally located or painless fissures; 3. concurrent fistula or significant hemorrhoidal disease; 4. inflammatory bowel disease; 5. diabetes mellitus; 6. pregnancy; 7. neurological disease; 8. spinal cord lesions, 9. use of cardiac pacemaker. males and females were considered for inclusion.
comparison of different concentrations of carbamide as moisturizers in ichthyosis vulgaris

Conditions: Ichthyosis Vulgaris

Summary: a randomized double blinded clinical trial will be conducted comparing the effect of two simple basic moisturizers only different in the concentration of carbamide (urea). the concentrations of carbamide will be tested are 0 and 7.5, respectively. the study will be conducted as a split-body-study and will contain two arms randomized to comparing 0 and 7.5 % carbamide, respectively. approximately 20 patients with at least clinically verified ichthyosis vulgaris will be enrolled to each study arm. the effect of the moisturizers will be assessed by clinical examination (score), patients assesment of effect and measurement of transepidermal water loss (tewl) and other skin parameters.


Eligibility criteria:
inclusion criteria: * clinically diagnosed with ichthyosis vulgaris exclusion criteria: * all other forms of ichthyosis
effect of behavioral therapy versus interferential current on bladder dysfunction in patients with multiple sclerosis

Conditions: Bladder Dysfunction on Patients With Multiple Sclerosis

Summary: study the effect of behavioral therapy and interferential current on management of bladder dysfunction in patients with multiple sclerosis

fifty patients with multiple sclerosis (ms) (secondary progressive type spms) suffering from bladder dysfunction were divided equally into two groups randomly; group a received biofeedback training (behavioral therapy) while group b received interferential training. both groups were assessed by urodynamics for detrusor pressure and maximum flow rate before and after eight weeks of behavioral therapy and interferential training. data analysis was managed using spss for windows, version 22 (spss, inc., chicago, il). the current test involved two independent variables. the first one was the (tested group); between subject factors which had two levels (group a received behavioral therapy and group b who received if ) .the second one was the (measuring periods); within subject factor which had two levels (pre, post). in addition, this test involved two tested dependent variables (detrusor pressure and maximum flow rate ) .t independent and dependent tests were used to compare between and within groups respectively. data was considered statistically significant when p \< .05

Eligibility criteria:
inclusion criteria: * all the patients were referred by a neurologist and the diagnosis was confirmed by the magnetic resonance image (mri).the duration of being diagnosed as spms for both groups were between one to two years. all the selected patients had normal mental examination according to mini mental scale .also, all the selected patients were medically stable. exclusion criteria: * patients with any other neurological deficits or orthopedics abnormalities or with auditory dysfunction were excluded from this study. patients with history of bladder dysfunctions before the diagnosis of ms or attaining any attack during the treatment period were also excluded.
assessment of safety of uk-390,957

Conditions: Ejaculation

Summary: to determine whether uk-390,957 is a safe treatment for premature ejaculation.


Eligibility criteria:
inclusion criteria: * subjects will have completed one of the phase 2 trials (a3871022/ a3871027/ a3871029) and will have met the diagnostic criteria for premature ejaculation as defined by dsm-iv exclusion criteria: * no drug related serious adverse events
comparing back extensor and core stability training in kyphosis

Conditions: Thoracic Kyphosis

Summary: to compare the effects of back extensor strengthening exercises versus core stability exercises on thoracic kyphosis in patients, assessing improvements in posture, spinal alignment, and overall functional outcomes

kyphosis is the normal forward curvature of our spine and when this curvature becomes excessively increased is referred to as hyper kyphosis or hunch back. its normal value is between 20 and 40 degrees. when the thoracic kyphotic angle exceeds 40 degrees, it is referred to as hyper kyphosis. the three main types of kyphosis often seen in individuals are postural, structural and congenital. postural kyphosis is caused by high external load on individual spine having overall poor muscle strength. sagittal misalignment can be caused by poor posture while sitting and standing as well as prolonged sitting.

Eligibility criteria:
inclusion criteria: * adults aged 18-40 years with a diagnosis of mild to moderate thoracic kyphosis (cobb angle between 40° and 60°). * the presence of back pain or discomfort is attributed to kyphosis. * willingness to participate and commit to the study's duration (6 weeks of intervention and follow-up). * ability to provide informed consent. exclusion criteria: * severe thoracic kyphosis (cobb angle \> 60°). * other spinal conditions such as scoliosis or spinal fractures. * previous spinal surgery or contraindications to physical activity. * neurological disorders affecting motor function. * pregnancy or severe medical comorbidities that would preclude participation.

Keywords: posture spinal alignment overall functional outcome pain range of motion
ventilator settings and outcomes in pediatric patients on ecmo for severe respiratory failure

Conditions: Critical Illness; Respiratory Failure (Pediatric Patients)

Summary: this study aims to describe the effects of ecmo initiation on the intensity of ventilation in the first 24 hours after ecmo initiation and to explore associations between changes in ventilation intensity and hospital mortality in critically ill pediatric patients requiring ecmo for respiratory failure, using the 'extracorporeal life support organization' (elso) registry.

rationale: despite the growing use of ecmo in critically ill pediatric patients, uncertainties remain to what extent adjustments of ventilator settings after ecmo initiation are associated with mortality. objectives: 1. to describe the effects of ecmo initiation on the intensity of ventilation in the first 24 hours after ecmo initiation; and 2. to explore associations between changes in ventilation intensity and hospital mortality in critically ill pediatric patients requiring ecmo for respiratory failure hypothesis: 1. ventilation intensity decreases following initiation of ecmo; and 2. a decrease in ventilation intensity is associated with lower hospital mortality in critically ill pediatric patients. study design: this is a posthoc analysis of the elso registry. study population: for this analysis, data will be obtained from the elso registry. all pediatric patients (aged ≥29 days to ≤18 years) receiving ecmo for a pulmonary indication between january 1, 2012, and december 31, 2022 will be included. patients with missing ventilatory variables required to assess ventilation intensity and patients lost to follow up with respect to hospital mortality will be excluded.

Eligibility criteria:
inclusion criteria: 1. patients (aged ≥29 days to ≤18 years) receiving ecmo between january 1, 2012, and december 31, 2022, in an elso affiliated center; and 2. requiring ecmo for a pulmonary indication. exclusion criteria: 1. patients with missing ventilatory variables required to assess ventilation intensity; 2. patients who were lost to follow up with respect to hospital mortality.

Keywords: ventilation practice critically ill children mechanical ventilation extracorporeal membrane oxygenation extracorporeal lief support
sf-qualiveen turkish validity and reliability study

Conditions: Multiple Sclerosis

Summary: urological dysfunction is common in patients with multiple sclerosis (ms) and its prevalence has been reported at a high rate of 32-97%. bladder dysfunction is associated with a significant deterioration in the quality of life of people with ms. in chronic diseases such as ms, patients experiences need to be measured directly in order to have information about patients perceptions about the effect of the disease on quality of life. however, there are a small number of valid and reliable turkish scales on this subject.sf-qualiveen is a validated scale for patients with ms who assess the urinary-specific quality of life by examining the impact of a wide range of bladder problems.the aim of our study is to make the turkish cultural adaptation, validity and reliability of the sf-qualiveen scale.

the aim of this study is to reveal the turkish cultural adaptation, validity and reliability of the sf-qualiveen scale. in our study, sf-qualiveen and urogenital distress inventory (udi-6) scales will be used. pre-testing will be done in 10 patients with multiple sclerosis.then, the validity and reliability of the scale will be performed in 80 patients with multiple sclerosis.

Eligibility criteria:
inclusion criteria: 1. age 18-65; 2. definitive diagnosis of ms according to mcdonald criteria; 3. ability to read and write in turkish. exclusion criteria: 1. acute attacks of ms (within 3 months); 2. cognitive impairment (mini mental test result 24 points and below); 3. any chronic disease other than ms; 4. active malignant tumors; 5. symptomatic urinary tract infections; 6. patients who changed treatment within the test-retest period.

Keywords: multiple sclerosis urological dysfunction assessment scale