Kornimate/medical-research-clean huggingface dataset:
project breast47: effect of an educational intervention

Conditions: Breast Neoplasm; Primary Prevention; Risk Factors; Telemedicine

Summary: breast cancer is the most frequently diagnosed malignant tumor in women. in 2018, in spain, the estimated incidence was 101/100,000 women. screening strategies and greater knowledge of risk factors by the population have contributed to a better prognosis. specifically, in the case of behavioral factors, making women aware of their influence enables them to establish preventive measures themselves. technologies are becoming a channel of communication, from a healthcare perspective, between the population and healthcare personnel. there are even specific terms like ehealth or mhealth. there is beginning to be evidence that collects the benefits and ways of using web-apps to achieve modification of risky behaviors and/or behaviors to prevent pathologies are acquired. the use of digital media, such as a web-app, to publicize bc risk factors makes it possible to specifically establish measures aimed at reducing its prevalence, which in turn will contribute to reducing the number of cases of bc. cm. on the other hand, making women aware of their bc risk factors, as well as quantifying the risk of developing the tumor, is useful for them to become aware of the magnitude of the problem and adopt measures to minimize their risk. since there is no digital strategy in asturias that informs and reduces the risk of developing breast cancer, through the modification of the main risk factors, in young women, the present study has been proposed with the aim of evaluating the effectiveness and feasibility of an educational intervention for bc risk prevention through the use of a web-app in women residing in health area vii of the principality of asturias.


Eligibility criteria:
inclusion criteria: * women who agree to participate with no previous diagnosis of breast cancer exclusion criteria: * women who do not have adequate physical or psychological characteristics to participate in the study * women who do not have the means to regularly access the web-app that will be used to develop the educational intervention * women who cannot be contacted by email
online childbirth preparation education in covid-19 pandemic

Conditions: Birth, First; COVID-19; Fear of Childbirth

Summary: today, pregnancy and childbirth are important life events that involve many difficulties and changes that must be overcome for both men and women. during this process, changes occur in the pregnant woman's body, emotional state and family life. these changes often cause pregnant women to experience anxiety about the baby's health and their own health, and to create new stressful situations. adding the pandemic conditions to this situation further complicates the process and it is seen that the fears of women towards the birth and postpartum period will increase even more. childbirth preparation classes reduce the fear and anxiety of women and create a positive perception of birth. for this reason, it is more important to give birth preparation education to women during in pregnancy during the pandemic period. however, it is not possible to give face-to-face birth preparation education to women in this process. for this reason, the aim of this study is to examine the effect of online childbirth preparation education in pregnancy on worries and fear of birth, preparation for birth, and well-being of self and baby in the covid 19 pandemic. the research is a pre-post test randomized controlled experimental study. the block randomization method will be used. the universe of the research will consist of women who applied to pamukkale university research and application hospital pregnant outpatient clinic, and have a healthy pregnancy at 24-34 weeks of gestation. the education will be done online. the sample size was calculated in the g\*power statistics program using the data of a study in which the childbirth preparation education intervention was previously performed (α =0.05, d=1.05). accordingly, it was found that 16 people should be taken for each group to sampling for 80% power. considering that there might be losses, the number of samples was increased by 10% and it was planned to include a total of 36 people in the study. intention-to-treat analysis will be performed to manage bias and losses.


Eligibility criteria:
inclusion criteria: * be over 18 years old * volunteering to participate in research * be at 24-34 weeks of gestation * be nulliparous * not having a high risk pregnancy * be able to read and write turkish * be able to fill out an online survey form * planning to have a normal spontaneous vaginal delivery exclusion criteria: * be under the age of 18 * not completing eight hours of childbirth preparation education * having a mental disorder that prevents answering survey questions * having a psychiatric illness * be able not use microsoft teams app

Keywords: online childbirth preparation fear of childbirth worries on birth preparation for birth well-being of self and baby covid 19 pandemic
can objective compliance monitoring increase mandibular advancement device usage in obstructive sleep apnea patients

Conditions: Obstructive Sleep Apnea

Summary: this study evaluates whether objective compliance monitoring can increase mandibular advancement device (mad) usage in obstructive sleep apnea (osa) patients. half of participants will be assigned to objective compliance monitoring group (experimental group), while the other will be assigned to subjective compliance monitoring group (control group). a physician will prescribe and explain to patients based on data from objective or subjective compliance monitoring.

the design of this study is a randomized controlled trial. total 40 participants are randomly divided into 2 groups: objective compliance monitoring (n=20) and subjective compliance monitoring (n=20). both groups wear the same mad (commercial name: somnodent flex with dentitrac). they visit seol national university hospital at 1, 3, and 6 month after the initiation of mad. a research coordinator acquires data by downloading from the mad or by asking the patients, and then transfer the information to the physician. if the patient belongs to objective compliance group, data from the mad will be transferred to the physician. but if the patient belongs to subjective compliance group, data acquired by asking patients will be transferred to the physician. a physician will prescribe and explain to patients based on data from objective or subjective compliance monitoring.the primary aims is to examine the effectiveness of somnodent flex with dentitrac, in terms of compliance.

Eligibility criteria:
inclusion criteria: * obstructive sleep apnea patients without a history of soft palate surgery and moderate to severe periodontal disease. exclusion criteria: * central sleep apnea * active mandibular disease * tooth grinding * moderate to severe periodontal disease
mri assessment of cartilage damage in tibial nailing

Conditions: Tibial Fractures

Summary: fractures of the tibia (shin bone) are frequently treated with a metal nail that is passed down the inside of the bone (an intra-medullary nail). this nail is inserted through the top of the tibia at the level of the knee joint. there are two ways for the nail to be inserted - either through an incision below the patella (kneecap) or above the patella. the benefit of the incision above the patella is that it can make it technically easier to insert the nail into the correct position. however, the perceived risk of damage to the knee cartilage has prevented this technique from being widely adopted. the investigators will use mri scanning to assess the cartilage for damage using both techniques. the results will enable the investigators to determine if the theoretical risk of cartilage damage is found in real-world scenarios and to generate data for further, larger studies.

intra-medullary nailing is a common form of treatment for a variety of tibial shaft fractures. traditionally this has been done via an infra-patella approach. more recently the use of a supra-patella approach has become more popular. however, there are concerns that the supra-patella approach may cause unacceptable damage to the cartilage of the patello-femoral joint (pfj). this study will use a novel mri technique developed at the university of cambridge to compare the amount of damage caused to the knee joint by both infra- and supra-patella nailing techniques. specific cartilage assessment sequences will enable a fuller assessment of cartilage damage than can be achieved with normal structural sequences. participants will also be asked to complete patient reported outcome measures (proms) regarding their injury to assess their clinical outcome. infra-patella and supra-patella nailing techniques are now both routine methods of carrying out intra-medullary nailing of the tibia. further evidence is required, however, in order to fully assess whether one method is superior to the other.

Eligibility criteria:
inclusion criteria: * closed tibial shaft fracture suitable for intramedullary nailing * able to consent * able to undergo mri scanning * able to attend follow up for 6 months post operatively * suitable for surgery exclusion criteria: * polytrauma * ipsilateral acute ligamentous knee injury * a contra-indication to mri scanning

Keywords: mri cartilage damage surgical techniques
project werk (wellness encouragement respect kinship)

Conditions: HIV Prevention

Summary: the project werk intervention is a brief, theory based and culturally sensitive intervention designed to capitalize on organic yet underutilized social support networks in the lives of young black men who have sex with men (ybmsm). the intervention has been developed with input from clients and their support network members, case managers, social workers, primary care providers. the goal of the intervention is to improve retention in prep care for young black msm.

project werk will recruit, consent and randomize 160 men, with 80 men randomized to each arm of the study. men randomized to the control condition will receive standard prep care at each clinical site. men randomized to the experimental condition will receive standard prep care and also will be asked to recruit a supportive contact from their social network. the support contact will then be engaged in a brief intervention designed to support their friend/family member around prep care. men and support contacts in the werk intervention also will receive booster sessions via telephone and text. all participants will complete surveys at baseline and at three and twelve months post intervention.

Eligibility criteria:
inclusion criteria index subjects: * self-identify as african american/black; * assigned male sex at birth; * any same gender anal or oral sex in the past 2 years; * english speaking; * have at least one support contact in their network; * own a cell phone not shared with other persons; * between the ages of 18-35 years old; and * have had fewer than 3 prep clinical visits in the past 12 months. support contact: * index participant has agreed to including the support contact * willing to attend face to face and telephone mini-booster sessions; * 18 years of age or older; * english speaking; and * owns a cell phone that is not shared with other persons. exclusion criteria index subject: * unable to provide informed consent; * plan to move out of the area within the next 12 months; * are not willing to attend intervention sessions; or * not willing to return for assessments. for index participants without a support contact, we will refer them to an appropriate support group for prep. support contact: * romantic partner of index participant; * unable to provide informed consent; * plan to move out of the area within the next 12 months; * are not willing to attend intervention sessions; or * not willing to return for assessments.

Keywords: pre-exposure prophylaxis (prep); retention in prep care
adolescents and health professionals faced with the necessity for changing to remote care during the covid-19 outbreak quarantine (adopro-cov19)

Conditions: Remote Consultation; Covid-19

Summary: the maison des adolescents (mda) at cochin hospital (paris) is a multidisciplinary service which welcomes adolescents in three different units: consultation, day care and hospitalization. however, the epidemic of coronavirus (covid-19) in march 2020 which imposed the extreme limitation of contacts and then the confinement of the entire population, required urgent adaptation of care practices. teleconsultation quickly became essential for most consultations (psychiatrists, psychologists, nurses, but also pediatricians and somatic physicians). in day hospital, daily reception could not be carried out, therapeutic workshops, family interviews, or speaking groups were organized remotely. in hospital unit, the interruption of visits required the organization of remote interviews with families. far from the comfort of an organized and structured telepsychiatry, the use of videoconferencing was done in an emergency and without preparation. the objective is to explore the experience of adolescents, doctors and psychologists regarding emergency changes in the methods of their follow-up by setting up teleconsultation in the context of the covid-19 epidemic.

the study will be monocentric, exploratory, and qualitative based on the interpretative phenomenological analysis. 15 adolescents followed in consultation, day hospital or full hospitalization and 15 health professionals working at the maison des adolescents will be included. semi-structured interviews will be carried out by a psychiatrist, based on flexible and evolving interview guides. qualitative analysis of adolescents and therapists' interviews will allow to explore the experience of teleconsultation by each group of participants and to inform about the advantages and limits of a teleconsultation device in adolescent care.

Eligibility criteria:
inclusion criteria: * adolescents aged between 11 and 20 years who benefit from follow-up in the structure (at least two face-to-face consultations before setting up teleconsultations) and for whom their follow-up had to be changed urgently in the form of teleconsultation from march 2020 as part of the covid-19 epidemic. adolescents will be included in the various consultation, day hospitalization and full hospitalization units. the pathologies will be varied so as to cover different situations and experiences: eating disorders, mood disorders, personality disorders, anxiety disorders, or even chronic somatic illness. * health professionals working at the maison des adolescents at the time of the epidemic, from different specialties (psychiatrists, pediatricians, psychologists, nurses, etc.) and units (consultations, day hospitalization, full hospitalization).

Keywords: qualitative research adolescent health personnel attitude coronavirus quanrantine
immunotherapy of gastric cancer with autologous tumor derived heat shock protein gp96

Conditions: Gastric Carcinoma

Summary: the purpose of this study is to evaluate the safety and effectiveness of autologous gp96 treatment of gastric cancer.


Eligibility criteria:
inclusion criteria: 1. disease characteristics: histologically confirmed gastric carcinoma: clinical stage iii (according to the japanese gastric cancer classification), must have undergone radical resection 2. able to read and understand the informed consent document, must sign the informed consent 3. age: 18 to 75 years old 4. availability of at least 0.5 g tumor sample 5. ecog ≤1；life expectancy \>=12 weeks, able to comply with study-related procedures 6. adequate bone marrow function including the absence of lymphopenia (anc \> 1,500/ mm3; hemoglobin \> 10g/dl ; platelet count \>100,000/mm3), adequate liver function (serum glutamic oxaloacetic transaminase/ aspartate aminotransferase \[ast\], alanine amino transferase \[alt\] \<2.5 times institutional upper limit of normals \[iulns\] and bilirubin (total) \<1.5 times iuln), and adequate renal function (bun and creatinine \<1.5 times iulns) 7. normal heart function 8. not participate in any other clinical trials within 4 weeks prior to vaccination. exclusion criteria: 1. unable to get the informed consent 2. female patients who are pregnant or breastfeeding 3. progression prior to treatment as determined by the principal investigator 4. transplant recipient 5. patients currently diagnosed with human immunodeficiency virus or other active uncontrolled infection 6. unstable or severe intercurrent medical conditions 7. patient with allergic constitution 8. patients with any systemic disease needed to be treated with immunosuppressant or corticosteroids.
barbershop talk: hiv prevention for african american heterosexual men

Conditions: HIV

Summary: this program utilizes a community-engaged research approach to implementing and evaluating a program that seeks to reduce sexual risk behavior among black adult heterosexual men. the investigators aims are to assess the impact of this linguistically and culturally tailored hiv prevention program on the sexual risk of heterosexual, african american men aged 18 and older, to assess the intervention's impact on the more proximal social and psychosocial variables that the program is designed to change, and to identify key contextual level factors that may impact the intervention's impact across segments of this priority population.


Eligibility criteria:
inclusion criteria: * unprotected sex in the past three months * identify as black or african american exclusion criteria: * having been in an hiv prevention research study in the last six months * reporting a history in the past five years of injection drug use * reporting a history in the past five years of having sex with other men * reporting an hiv-positive serostatus * inability to understand spoken english.

Keywords: hiv prevention men african american
a study of avastin (bevacizumab) and oxaliplatin plus xeloda (capecitabine) in patients with advanced colorectal cancer.

Conditions: Colorectal Cancer

Summary: this study will assess the efficacy and safety of treatment with the combination avastin (bevacizumab) 5mg/kg iv every 2 weeks, xeloda (capecitabine) 1000 mg po b.i.d. on days 1-14 of every 28-day cycle and oxaliplatin 40mg/m2 iv weekly in patients with inoperable locally advanced or metastatic colorectal cancer. the anticipated time on study treatment is until disease progression.


Eligibility criteria:
inclusion criteria: * adult patients \>=18 years of age * locally advanced or metastatic colorectal cancer * no previous treatment with chemotherapy for metastatic disease * measurable and/or evaluable lesions exclusion criteria: * radiotherapy within 4 weeks before study * untreated brain metastases or primary brain tumors * chronic, daily treatment with high-dose aspirin (\>325mg/day) * co-existing malignancies, or malignancies diagnosed within the last 5 years, with the exception of basal and squamous cell cancer, or cervical cancer in situ
striatal and extra-striatal mechanisms of falling in parkinson's disease

Conditions: Parkinson's Disease

Summary: this research study will evaluate functions of memory, thinking, eye movements and walking and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using an imaging procedure called positron emission tomography (pet). you may know that the brain chemical dopamine, a "neurotransmitter" substance (a chemical messenger that nerve cells need to communicate with each other), is important for the brain to control movements and that the brain chemical acetylcholine may have functions related to mental concentration and attention. at the present time, the investigators have no clear information how these two chemicals in the brain of patients with parkinson's disease are related to the risk of falling.

although most research in pd has a focus on presynaptic dopaminergic denervation, new lessons may be learned by exploring to what extent alterations in non-motor and non-dopaminergic systems may play a role in the balance impairment in this disorder. this project is designed to evaluate striatal pre-synaptic dopaminergic, cortical, thalamic, and brainstem cholinergic, cognitive, and oculomotor mechanisms underlying the risk of falling and imbalance in pd. the proposed study will exploit advances in our center in the development of dynamic biomathematical modeling of electronic platform data, application of specialized cognitive and oculomotor assessments, and positron emission tomography (pet). this novel multi-system approach holds promise for understanding mechanisms of falling in pd beyond pre-synaptic dopaminergic nigrostriatal denervation.

Eligibility criteria:
inclusion criteria: * subjects considered for inclusion will be female or male subjects either currently enrolled or eligible for care at the va aged 50-85 years, or community volunteers. * the racial, gender and ethnic characteristics of the proposed subjects population reflect the demographics of the patient population of the va. however, extra efforts will be made to recruit women and minorities (see table 5). * children will be excluded from the study. * no exclusion criteria shall be based on race, ethnicity, gender, or asymptomatic hiv status. exclusion criteria: * inability to stand or walk independently (i.e., patients in hoehn and yahr stage iv and v). * vertiginous disorder. * orthostatic hypotension or unstable cardiovascular disease at risk of syncope (drop in systolic blood pressure of \> 20 mm hg upon standing). * history of stroke with focal cortical lesions. * cerebellar, myelopathic or significant radiculopathy syndrome. * diminished light perception in both eyes (\< 20/40 corrected ou). * intracranial surgery. * subjects who have participated in other research protocols such that their cumulative radiation absorbed dose to whole body, gonads, bone marrow or lens of the eye would exceed 5 rem, or dose to other body organs is more than 15 rem in preceding 12 months. * pregnancy (beta-hcg test within 48 hours of pet study) or breastfeeding. * contra-indications to mri.