adapted physical activity effect on abilities and quality of life of huntington patients and relatives during rehab stay

Conditions: Huntington Disease

Summary: intro: huntington's disease is a neurodegenerative disease that affects the brain, inducing a dysfunction and death of the middle spiny striatal projection neurons and a progressive alteration of cognitive and motor functions, and psycho-behavioral problems. there is currently no curative treatment but we know hat a multidisciplinary care can optimize the functioning and the quality of life of the patients with huntington's disease. a meta-analysis of 18studies indicates that exercise and physical activity can improve motor function, gait speed and balance, and would also improve self-confidence, independence, well-being, reduced apathy and better socialization with family and friends. hypothesis/objective the hypothesis is that the inclusion of a 4 week-program with adapted physical activity (apa) during a rehabilitation stay will improve some motor, cognitive and psycho-behavioral abilities, compared to the control group. method the patients will be randomized into two groups : the control group will have the "classic" program performed in the standard of care with: kinesitherapy, soft gym, medico-social workshop, cognitive workshop, creative workshop, individual care (rehabilitation, rest, and creation). the experimental apa group will have in addition of the classic program, 6 apa workshops per week with collective support : adapted physical workshops, adapted cycling, therapeutic (horseback/equestrian) riding, cultural or leisure outings, situation tests for the two groups, at the start of the 4 weeks of rehabilitation program an initial visit will be performed with, as part of this research, a clinical examination, a neurological examination, a dietary consultation, as well as a biological assessment as part of habitual care. the clinical examination, the neurological examination and the dietary consultation will be performed each week, during the 4 weeks of the program, at the end of the study, one month after the rehabilitation of the patient, a visit by phone-call will be performed for the patient and his caregiver.


Eligibility criteria:
inclusion criteria for the patient : * mid-stage huntington's disease but with the ability for an autonomous walking for 10 meter * age ≥ 18 years old * stable medication for at least 4 weeks before the start of the study and a stable diet during the duration of the program. a stable diet means no weight loss up to 2kg in the last month prior to inclusion * patient who received a complete information and who signed an informed consent for the research (or his/her caregiver if incapacity to sign). tutor/guardian who received a complete information and who signed an informed consent for the research if applicable * affiliated to a social security scheme inclusion criteria for the caregiver : * person participating in the daily life of the patient * the patient is included in the research * age ≥ 18 years old * having received a complete information * non opposition collected by the investigator exclusion criteria: * having a physical or psychiatric condition preventing the completion of the program and assessments. * having a history of additional major neurological disorders such as a stroke or an orthopedic condition limiting mobility * any difficulty to understand or read french which could possibly invalidate the relevance of the application of questionnaires according to the opinion of the investigator * addictions, alcohol dependence * any other neurological, musculoskeletal or cardiovascular disease which could lead to errors in the assessment * participation to another interventional research or being in the exclusion period following a previous research if applicable * patient under ame (except if exemption from affiliation) exclusion criteria for the caregiver : * having a physical or psychiatric condition preventing the completion of the program and assessments. * any difficulty to understand or read french which could possibly invalidate the relevance of the application of questionnaires according to the opinion of the investigator * under tutelage or guardianship

Keywords: adapted physical activity huntington's disease rehabilitation