Kornimate/medical-research-clean huggingface dataset:
pediatric cardiac output monitoring observational study

Conditions: Pediatric ALL

Summary: to assess cardiac output monitoring in pediatric subjects by comparing flotrac and clearsight system to intermittent thermodilution swan-ganz, in order to expand the indications of flotrac, clearsight and swan-ganz thermodilution pulmonary artery catheter to the pediatric population 12 to 18 years of age.


Eligibility criteria:
inclusion criteria: * subjects who are 12 to 18 years of age * subjects who have signed the informed consent form * subjects who are projected to receive swan-ganz catheter as part of procedure/standard of care with intermittent cardiac output measures * for those subjects who have had a cardiac transplant,subjects who are at least 2 weeks post cardiac transplantation * subjects with planned pressure monitoring with an arterial line exclusion criteria: * subjects with contraindications for pulmonary artery catheters placement and monitoring (recurrent sepsis, or with hypercoagulopathy); * subjects with contraindications for arterial line placement; * subjects with an extreme contraction of the smooth muscle in the arteries and arterioles in the lower arm and hand (i.e., raynaud's disease). * subjects with a physical site area too limited for proper sensor placement * subjects with finger size less than the smallest finger cuff size * documented ≥ moderate pulmonary hypertension (papm \> 25mmhg, pvri \> 3.0 wuxm2) * presence of intracardiac shunting (i.e., asd, vsd) * aorto-pulmonary collaterals * ≥ moderate tricuspid regurgitation, per echocardiogram criteria * \> moderate aortic or pulmonary regurgitation, per echocardiogram criteria * persistent cardiac arrythmias during the cardiac catheterization period (\> 3min) * vascular abnormalities of the arterial system (i.e., connective tissue disorders, mid-aortic syndrome)

Keywords: hemodynamic monitoring cardiac output
clinical trial to assess efficacy, safety and tolerability of botulinum toxin a (xeomin®) in treatment of expression wrinkles in the upper third of the face

Conditions: Skin Aging

Summary: the purpose of this study is to determinate whether xeomin® (botulinum toxin type a) is safe, effective and tolerable in woman aged 30 to 50 years old for treatment of mild, moderate or severe expression lines (wrinkles) in the upper third of the face. the main outcome was the change in appearance of the wrinkles two weeks (visit 3) after product application as compared with baseline assessment.

ageing is a dynamic and unchangeable process involving all individuals and affecting the several organic systems. this process is expressed through multiple symptoms and signs, the wrinkles and flaccidity being the most common and visible ones. in both developed and emerging countries, the interest in skin ageing is, to a greater extent, the result of the progressive increase in the absolute number and the proportion of people experiencing the ageing process in the last century. the psychosocial, as well as the physiological effects of the skin ageing raised a huge demand for a better understanding of this process and, in particular, of the effective interventions. the use of the botulinum toxin type-a (btx/a) for aesthetic indication emerged as a result of the clinical observation of those patients treated for facial different dystonia and who presented additional improvement of their expression lines. the expression lines are most easily noted on the upper third of the face, where surgical treatments are fully invasive and show lesser noticeable results. the upper third of the face was targeted for btx/a treatment and reported in several scientific literature articles as well succeeded.

Eligibility criteria:
inclusion criteria: * women aged 30 to 50 years old, inclusive. * mild, moderate or severe expression wrinkles. * patients who had understood and signed the informed consent form. exclusion criteria: * subjects treated with botulinum toxin on the upper third of the face within the previous 6-month period; * former implantation of permanent material and surgery (scars). * use of any anticoagulant agent up to 7 days prior to the investigational product application; * concomitant use of aminoglycosides or of any other drug that may impair in the neuromuscular transmission; * coagulopathies and local inflammation/ infection at the application site. * diseases which do impact on the neuromuscular function, such as: myasthenia gravis, eaton lambert syndrome; * pregnancy or breast feeding, women with potential to become pregnant or who do not agree to use an effective contraception method (pearl index \< 1%); * allergy or known sensitivity to any of the components of the investigational drug; * subjects who were enrolled in other clinical trial for the last 12-month period prior to the present study, as per resolution 251/97; * subjects who disagree with the study procedures, who do not sign the informed consent form or who are not committed to participate in the trial.

Keywords: botulinum toxin a wrinkles
the establishment of the early intervention program for patients with schizophrenia

Conditions: Schizophrenia

Summary: schizophrenia is a severe mental illness, which has a prodromal phase of 1-2 years prior to the onset of the illness. during the prodromal phase, patients might show maladaptation and/or poor social functioning. however, these early symptom of schizophrenia might be overlooked by patients and their families. at that period, patients might strive to improve their social interactions and social functioning. however, the efforts might further create their stress level on everyday life, which can actually accelerate the illness onset of schizophrenia. in other words, the efforts would worsen the pathophysiologic changes in the brain, which can result in the positive symptoms of schizophrenia. previous researches found that the critical period for treatment of schizophrenia is the early phase of illness onset, especially the first two or three years. delay treatment would worsen the illness. to this extent, early treatment would bring to a better prognosis as well as minimize the costs of individuals, families and society. in other words, early interventions not only can prevent relapse, it also can benefit patients' psychosocial adjustments. however, researches found that the average duration of untreated psychosis is 25.2 months in taiwan, which indicates the phenomena of delay treatment and this trend might result in missing the critical treatment period. this is a two years study aiming to establish an early intervention program for patients with schizophrenia. in the first year, it aims to understand the phenomena of psychiatric care services utilization for patients with schizophrenia, special emphasis will be on the delay treatment and pluralistic health seeking process. in the second year, it aims to establish an early intervention program. the results of this research would contribute to in-service trainings, service providing, and policy making of psychiatric services.


Eligibility criteria:
inclusion criteria: * patients with schizophrenia * capable to express in chinese * willing to cooperate with exclusion criteria: * patients with schizophrenia but not willing to cooperate with
"pharmacokinetic study of fondaparinux in inpatients with renal dysfunction"

Conditions: Renal Insufficiency

Summary: the purpose of this study is to determine a preventative dose of study drug, arixtra® for patients with kidney disease. we will measure the blood levels of arixtra® in patients with kidney disease and develop guidelines for dosing.


Eligibility criteria:
inclusion criteria: * inpatients who are 18 years or older * estimated creatinine clearances between 20-50 ml/min * current hospitalization for a cancer-related abdominal, breast surgery or elective orthopedic surgery * able to give informed consent * need for prophylactic anticoagulant therapy for increased risk of a thrombotic episode exclusion criteria: use of the following * clopidogrel, aspirin, or nsaid usage,(usage is prohibited while patients are participating in the study) * body weight \< 50 kg * anticoagulation therapy for thrombosis or other indication * pregnant or breast-feeding * hypersensitivity to arixtra® * thrombocytopenia associated with a positive in vitro test for anti-platelet antibody in the presence of arixtra® * bacterial endocarditis * brain malignancy * increased risk of bleeding.
the incidence and progression of myopia: cohort study

Conditions: Myopia

Summary: a cohort study on incidence and progression of myopia in a group of medical students

a prospective cohort study to investigate the refractive error development, progression and their risk factors in young adult population comprises a group of medical students in china for two years

Eligibility criteria:
inclusion criteria: * volunteer subject, , willing to follow the protocol and able to read, comprehend and sign the informed consent form, * age between 17 and 23 years exclusion criteria: * vulnerability of the subject, * participation in another study which might have an influence on vision or interfere with study assessments, * aphakic or pseudophakic (intraocular lens) * participants who are wearing ortho-k lenses, or undergone any kind of myopia control treatments or undergone refractive surgery. * any current or evolving pathology manifested in the eye or the appendages which might have an influence on vision, or interfere with study assessments (e.g. amd, glaucoma...), * any previous ocular surgery which might have an influence on vision or interfere with study assessments (e.g. iridectomy, refractive surgery...), * any untreated and/or uncontrolled systemic condition which might have an influence on vision, or interfere with study assessments (e.g. uncontrolled diabetes, uncontrolled high blood pressure...), * any medical treatment or medication which might have an influence on vision or interfere with study assessments (e.g. antidepressants, drugs with atropinic effects...),

Keywords: myopia
unobtrusive technologies for monitoring of autonomic nervous system function in elderly frail patients

Conditions: Frailty; Autonomic Nervous System Imbalance

Summary: to develop and investigate an unobtrusive technology for long-term monitoring of autonomic nervous system (ans) function's response to daily physical stressors and exercise training for elderly patients with different frailty stages.


Eligibility criteria:
inclusion criteria: * patients admitted to cr after open heart surgery. * age 65 years and older. * 6-minute walk distance (6-mwd) ≥150 meters. * patient's agreement to participate in the study. * edomonton frailty scale score 5 points and more exclusion criteria: * cardiac devices (due to artificially altered heart rate series) * diseases in the musculoskeletal system or other organs complicating physical activity and exercise training; * exercise-limiting comorbidities (primarily orthopedic and neurological conditions that would exclude individuals from participating in cr according to study protocol), including chronic heart failure new york heart association class iv, hemoglobin less than 9 g/dl, wound healing disturbance, cognitive or linguistic deficits.

Keywords: cardiac rehabilitation cardiac surgery resistance training exercise training frailty elderly
acupuncture for sedation in the intensive care unit (icu)

Conditions: Delirium; Respiratory Depression; Overmedication

Summary: background many patients in the trauma intensive care unit (ticu) require mechanical ventilation and sedation or anxiolysis. mechanical ventilation means that a machine is helping a patient breathe if he can't breathe on his own. because of the mechanical ventilation, these patients also require some medication to help keep them calm. these are called sedatives or anxiolytics. the purpose of this study is to see if acupuncture can lower the amount of sedation and anxiolysis needed by a subject during mechanical ventilation in the ticu. acupuncture is a medical procedure. hair-thin sterile needles are inserted at specific points on the body. procedures some subjects will get acupuncture and others will get 'fake' acupuncture. by using 'fake' acupuncture, no one other than the acupuncturists will know which group a subject is in. subjects and the team do not get to pick which subject is in which group. instead, the groups are picked randomly. subjects will get real or fake acupuncture twice a day for five days. standard of care - both groups will receive the standard of care while in the study. they will be mechanically ventilated and given sedatives and analgesics based on the ticu protocol. real acupuncture group - this group will receive real acupuncture with real needles. these are stainless steel, one time use, needles. this group will also receive "ear tacks" which are like little needles that can stay on the ear for a few days. the ear tacks will be covered with a bandage so no one can tell which group the subject is in. sham acupuncture group - this group will receive sham needles. these needles retract into themselves much like a 'magic sword' rather than poking the skin. subjects in this group will not get ear tacks. in order to hide the group the subject is in, a bandage will be used to cover part of the ear. hypothesis real acupuncture will decrease subject's sedation requirements by 30% when compared to the sham acupuncture group.


Eligibility criteria:
inclusion criteria: * trauma patient ≥ 18 years admitted to the trauma icu * injury severity score (iss) ≥ 4 * mechanically ventilated \ 24 hours exclusion criteria: * inability to obtain consent from patient or designee * receiving immunosuppressive therapy * receiving therapeutic anticoagulant therapy * history of bleeding disorder, inr \> 1.5, ptt \> 65, plt \< 20k * pregnancy * three (3) or more inaccessible acupoints * head injury with elevated intracranial pressure or requiring operation * patients with midline abdominal incision * non-english speaking * receipt of dexmedetomidine prior to or during study period

Keywords: anxiolytics sedatives acupuncture therapy
qt changes as detected from linq ecg during antiarrhythmic loading (linq qt)

Conditions: Atrial Arrhythmia; QT Interval, Variation in; Arrhythmias, Cardiac

Summary: the linq qt study is a prospective, non-randomized, multi-center, observational, post-market clinical study investigating qt interval changes due to antiarrhythmic drug loading.

the purpose of this study is to determine if qt interval changes are detected during and after antiarrhythmic drug loading by the designed qt detection algorithm from linq ecg. the qt intervals during the anti arrhythmic loading hospitalization period will be compared for all patients to analyze qt changes that may be caused due to antiarrhythmic drugs.

Eligibility criteria:
inclusion criteria: * patients implanted with linq/linqii prior to the study enrollment (no more than 50% patients implanted with linqii), but no greater than 2.5 years for linq or 3.5 years for linqii, or patients who are indicated to receive a linq/linqii implant at least 7 days prior to antiarrhythmic drug loading * patients who are scheduled to receive antiarrhythmic drug loading * age 18-80 * patient is willing and able to comply with the protocol, including follow-up visits, and performing holter recordings and patient activation transmissions exclusion criteria: * patients who have a contraindication to long-term antiarrhythmic therapy * patients not suitable for long-term antiarrhythmic therapy * patients with a previous, existing cardiac implantation (i.e., cardiac pacemaker or cardiac resynchronization requiring \> 40% pacing, implantable cardioverter defibrillator (icds)) * patients with permanent and persistent af * co-enrollment in another study or planning to participate in a concurrent device study during the course of this clinical study that could confound the results
efficacy of communication modalities for promoting flu shots

Conditions: Influenza Vaccination; Health Promotion; Health Behavior; Risk Reduction

Summary: the purpose of this study is to test which modalities (mailed letter, short message service \[sms\] text, or patient portal messages) are most effective for encouraging flu shots in high-risk patients.

the centers for disease control (cdc) recommends a flu vaccination to everyone aged 6+ months, with rare exception; almost anyone can benefit from the vaccine, which can reduce illnesses, missed work, hospitalizations, and death. flu shots are particularly important for patients at high risk of experiencing severe outcomes. during the 2020-21 and 2021-22 flu seasons, the study team sent messages to geisinger patients in the top 10% of risk for flu and complications according to an artificial intelligence algorithm. messages that told patients they were at high risk significantly increased their likelihood of getting vaccinated. the present study will extend previous work by testing which modality or modalities are most effective at boosting flu shot rates in patients at high risk. in previous campaigns, patients received messages via all communication modalities patients were eligible for (mailed letter, sms text, and/or patient portal message). in this study, patients will be randomized to receive high-risk messages in one or more modalities.

Eligibility criteria:
inclusion criteria: * included on a list of active geisinger patients (all patients on this list attended at least one primary care appointment at geisinger between 10/1/2008 and 4/13/2022, and either had a geisinger primary care provider assigned as of april 2022, or were in the electronic health record \[ehr\] since at least september 2021 and had at least one encounter in 2020-2022) * aged 18 or older * in the top 10% of risk for flu and flu complications, according to medial's flu complications machine learning algorithm (which operates on coded ehr data) * has a geisinger pcp assigned as of august 2022 * has had an encounter in the last 2 years as of august 2022 exclusion criteria: - cannot be contacted via any of the communication modalities (e.g., letter, patient portal, sms) being used in the study, either due to insufficient/missing contact information in the ehr or because they opted out of all modalities

Keywords: flu vaccine choice architecture machine learning perceived credibility
correlation of particulate matter and heme oxygenase-1 protein activity in asthmatic children by induced sputum analysis.

Conditions: Asthma

Summary: samples of sputum from asthmatic children, between 5-17 years, will be collected during two years of the study period to perform tests particle size distribution (psd) and shape analysis (sa) of the particulate matter in the sputum and a biochemical reaction to evaluate the activity of heme oxygenase-1 protein in sputum cell supernatants. each child will perform pulmonary function testing (pft) and induced sputum (is) as a routine part of diagnosis of asthma. parents will be asked to complete a questionnaire including questions on their child's respiratory symptoms in the last 12 months as well as socioeconomic factors. parents will be asked to give informed written consent for their child's participation in the study.


Eligibility criteria:
inclusion criteria: * •all children, between 5-17 years, performing a routine diagnosis of asthma in tel aviv sourasky medical center that there parents gave informed written consent for their child's participation in the study. exclusion criteria: * none.
screening of endovascular thrombectomy with mri in acute ischemic stroke

Conditions: Fluid-attenuated Inversion Recovery Sequence Vascular Hyperintensity-diffusion-weighted Imaging Mismatch(FVH-DWI Mismatch); Image Evaluation; Endovascular Thrombectomy

Summary: the goal of this observational study is to learn about the role of mri evaluation based on fvh-dwi mismatch principle in preoperative evaluation of endovascular thrombolectomy. the main questions it aims to answer are: * the consistency between mri and perfusion examination in determining evt indications. * the consistency of functional independence rate between patients screening with mri and perfusion.

mri is the preferred imaging mode in many centers,for the diffusion-weighted imaging (dwi) sequences are highly sensitive to acute cerebral ischemia.in addition, mri does not require intravenous contrast agent, which is simpler and more popular than perfusion.fluid-attenuated inversion recovery (flair)sequence vascular hyperintensity(fvh) is defined as focal, serpentine, or linear hyperintensity that usually occurs in the sylvian fissure and is associated with large-vessel occlusion or stenosis.the fvh-dwi mismatch(defined as the fvh extended beyond the boundary of the dwi cortical lesions) had been confirmed has excellent sensitivity and specificity in predicting pwi-dwi mismatch.it is not well established whether mri based on fvh-dwi mismatch and perfusion evaluation differ in determining evt indications and outcomes. the main objectives of this study were to (1) determine the proportion of patients eligible for evt surgery selected by mri based on fvh-dwi mismatch vs perfusion in a large multicenter registry and (2) identify statistical differences in functional outcomes and safety outcomes between the two evaluation methods. patients with ischemic stroke with anterior-circulation large-vessel occlusion in the late (6-24 h) time window from real-world, single center retrospective cohort registry were compared.in the mri group, patients with fvh-dwi mismatch underwent evt surgery or were otherwise treated with medication.in the perfusion group, surgical indications referring the defuse 3 standards. the primary outcome was 90-day functional independence rate (mrs score ≤2) in all patients included(including evt patient and medication patients).safety outcomes included symptomatic intracranial hemorrhage (sich), and 90-day mortality.

Eligibility criteria:
inclusion criteria: * (1) age ≥ 18 years old; * (2) symptoms consistent with acute ischemic stroke and an onset time of 6-24h; * (3) ct aspects score≥6 points;nihss≥6points; modified rankin scale (mrs) of 0-2 points prior to stroke; * (4) internal carotid artery (ica) and/or m1 segment of middle cerebral artery (mca-m1) and m2 proximal segment occlusion with definite diagnosis. * (5)agree to comply with the protocol follow-up requirements. exclusion criteria: * (1)image unanalyzable. * (2)3 months follow-up was not completed

Keywords: fvh-dwi mismatch;endovascular thrombectomy