Kornimate/medical-research-clean huggingface dataset:
active surveillance magnetic resonance imaging study

Conditions: Prostate Cancer

Summary: this is a multi-centre, prospective, randomized phase iii trial to determine if multi-parametric magnetic resonance imaging (mri) can improve selection of patients eligible for active surveillance through better detection of clinically significant cancer.


Eligibility criteria:
inclusion criteria: * histological confirmation of adenocarcinoma of the prostate * candidate for active surveillance (favourable risk prostate cancer) as defined by the following: * clinical stage t1b, t1c, t2a or t2b at the time of diagnosis * clinical (diagnostic biopsy) gleason sum \< 6 * psa \< 10.0 ng/ml (ug/l) exclusion criteria: * previous treatment for prostate cancer including surgery (excluding biopsy), radiation therapy, hormonal therapy (e.g. megestrol, medroxyprogesterone, cyproterone, des), glucocorticoids (except inhaled or topical), lhrh analogues (e.g. leuprolide, goserelin), ketoconazole, non-steroidal antiandrogens (e.g. bicalutamide, flutamide) and/or any 5α-reductase inhibitors within 3 months of randomization * planned anti-androgen therapy * inability to undergo trus biopsy * inability to undergo multi-parametric mri

Keywords: active surveillance low risk prostate cancer
effects of an aquatic therapy program versus a land program in patients who suffered a stroke

Conditions: Stroke; Hydrotherapy

Summary: the objective of this study is to investigate the relative effectiveness of cct on water versus on land in stroke patients. additionally, the study will to determine if there are differences in the results obtained, between two cct programs in the following parameters: gait, balance and dexterity

this study is a randomized controlled trial of the effectiveness of a structured cct program in water versus a structured cct program on land in the rehabilitation of stroke survivors.

Eligibility criteria:
inclusion criteria: * patients with diagnosis of stroke (ischemic or hemorrhagic) onset ≤ 3 years; with hemiparesis secondary; * age ≥18 to ≤ 90; * provide a written informed consent; * able to walk for at least 10 m without assistance exclusion criteria: * patients with uncontrolled or risky conditions (acute myocardial infarction, arrhythmia, heart failure, uncontrolled hypertension or unstable cardiovascular state); * with infectious diseases, ulcers or urinary and / or faecal incontinence; * additional neurological and / or orthopedic deficits that alter ambulation; * unable to follow treatment (cognitive, visual ...).

Keywords: circuit class therapy icf model aquatic therapy neuro-rehabilitation
early integrated intervention in severe affective disorders

Conditions: Depressive Disorder; Bipolar Disorder

Summary: the purpose of this study is to determine whether early integrated prophylactic combined medical and psychological outpatient treatment is associated with a better prognosis in patients with severe unipolar and bipolar affective disorders than standard treatment.

patients who have been hospitalised for unipolar or bipolar disorder have a poor prognosis with highly increased risk of recurrence of episodes and increased risk of psychosocial dysfunction. it seems as integrated prophylactic combined medical and psychological out-patient treatment may lead to a better long-term prognosis in patients with affective disorders in general. it has not been specifically investigated whether such integrated treatment may improve long-term outcome if the intervention is offered early in the course of the affective illness. subjects: patients currently discharged from first, second or third hospitalisation ever from psychiatric department with a diagnosis of severe single depressive episode/recurrent depression or with a diagnosis of manic/mixed episode or bipolar disorder. comparison: early intervention with integrated prophylactic combined medical and psychological outpatient treatment as offered by a clinic for affective disorders compared with standard outpatient treatment as offered by community psychiatric centres, private specialists in psychiatry or general practitioners.

Eligibility criteria:
inclusion criteria: 1. discharge diagnosis of severe single depressive episode, recurrent depression, manic/mixed episode or bipolar disorder exclusion criteria: 1. moderate to severe dementia 2. incapable in understanding or reading danish 3. earlier randomised to the trial

Keywords: prophylactic treatment pharmacological treatment psychological treatment
the grk2 inhibitor paroxetine as a novel adjunct to conventional therapy in rheumatoid arthritis patients

Conditions: Rheumatoid Arthritis

Summary: among three mapk families, paroxetine was found to be able to decrease the phosphorylation of erk. it was reported that paroxetine attenuates the symptoms of collage induced arthritis rats due to its inhibitory effect on t cell activation and infiltration to synovial tissue via suppression of erk pathway. this study aimed to evaluate the therapeutic efficacy of paroxetine in rheumatoid arthritis. paroxetine prevents the joint inflammation which is at the very early stage. paroxetine could inhibit grk2 with selectivity over other grks. medications developed for maintaining the immunologic equilibrium. such as grk2 inhibitors, will be the novel trends in ra treatment that could avoid the adverse side effects that are common with current treatment options.


Eligibility criteria:
inclusion criteria: • patients with active rheumatoid arthritis based on das28 score. patients received the standard therapy (i.e. one or more conventional dmards) for at least three months. exclusion criteria: * known hypersensitivity to metformin. * patients who have a prior diagnosis with diabetes mellitus. * patients receive metformin for any other indications. * patients with congestive heart failure. * patients with a history of myocardial infarction. * patients with severe anemia. * patients with active infections or other inflammatory diseases. * patients receiving biological therapy. * pregnancy or lactation. * patients with impaired liver functions. * patients with impaired kidney functions (serum creatinine concentrations ≥1.5 and ≥1.4 mg/dl in males and females respectively). * patients with malignancies.
bfr after biceps tendon repair and mpflr

Conditions: Patellofemoral Joint Dislocation; Bicep Tendon Rupture

Summary: the purpose of this study is to examine the effect of utilizing blood flow restriction (bfr) therapy after distal biceps tendon repair or medial patellofemoral ligament reconstruction (mpflr) following a tear.


Eligibility criteria:
inclusion criteria: * subjects will be recruited from our ambulatory sports medicine clinics. we will include patients aged 18-80 who suffered a biceps tear and are undergoing biceps repair or mpflr exclusion criteria: * subjects will be excluded if they are undergoing revision biceps repair or revision mpflr, history of dvt, neurovascular injury, unable to tolerate bfr treatment, unable to complete physical therapy, peripheral vascular disease * subjects will be withdrawn from the study if they are unable to tolerate the bfr therapy. additionally if they suffer from any complications of the therapy they will be withdrawn immediately. this will be facilitated by describing the reasons for withdrawal to the patient prior to initiating the study and ask patients and other providers to inform the investigators if there are any issues or concerns.

Keywords: bicep tendon repair medial patellofemoral ligament reconstruction
a comparative clinical study to assess pain score and wound healing following fractional ablation with a dfg laser and co2 laser

Conditions: Healthy

Summary: this research study aims assess whether the difference frequency generation (dfg) laser could be a better alternative to the co2 laser in terms of reduced side effects and patient downtime.

the primary goal of this study is to compare the pain score and wound healing time in healthy subjects undergoing low fluence fractional ablation using the dfg and co2 lasers. the secondary objective involves assessing the impact of each laser on dermal vasculature using an optical coherence tomography (oct) imaging system. participants will be treated with the dfg and co2 laser to the upper thighs. photography, pain scores, and oct imaging will be recorded over the course of the study visits. the investigators plan to enroll 23 healthy subjects to complete the study. subjects must be equal to greater than 18 years old and may be any gender or fitzpatrick skin type.

Eligibility criteria:
inclusion criteria: * subjects must be able and willing to provide written informed consent and comply with the requirements of the study protocol; * subjects must be in good general health, based on answers provided during the screening visit; * subjects must be able to read and understand english. * subjects must be above the age of 18. * subjects must have no history of skin conditions that affect the integrity of the skin barrier. exclusion criteria: * are pregnant or lactating; * have a history of drug or alcohol abuse or have reported habitual alcohol intake greater than 2 standard drinks per day \[e.g., 2 beers, 2 glasses of wine, or 2 mixed drinks\]; * are smoking or have a history of smoking; * presence of eczema, psoriasis, skin wounds or ulcers, or any other skin disease on the thighs; * have birth marks, tattoos, scars, or any other disfiguration of the skin in the skin area of interest; * presence of sunburn or tan in the treatment area; * use of any topical application of retinoids in the area of interest or systemic retinoids in the past 6 months; * use of any prescription topical medication, such as corticosteroids or hydroquinone on the skin area of interest in the past 6 months; * history of blood-clotting abnormality; * history of keloid formation or hypertrophic scarring; * history of allergic reaction to local anesthesia, aluminum chloride, and/or glycerol; * investigator, interfere with study evaluations or pose a risk to subject safety during the study; * exhibits any clinical conditions or takes any medication which in the opinion of the investigator may interfere with the study or pose a risk to subject safety during the study; * is not able to follow study protocol.

Keywords: laser
study of the impact on survival of a paradigm shift in the therapeutic strategy of patients with advanced ovarian cancer

Conditions: Ovarian Cancer

Summary: ovarian cancer is the 8th leading cause of cancer-related death in women. its prognosis is poor, with diagnosis often made at an advanced stage. patient management has evolved in recent years with more radical surgeries and the introduction of maintenance treatment following neoadjuvant chemotherapy.


Eligibility criteria:
inclusion criteria: * adult patient (≥18 years old) * operated on at the hus between january 1, 2010 and december 31, 2022 * having undergone primary or interval cytoreductive surgery * suffering from stage figo iiic or iv high-grade serous carcinoma of ovarian origin exclusion criteria: * patiente ayant exprimé son opposition à la réutilisation de ses données à des fins de recherches scientifiques. * autres types histologiques de cancer de l'ovaire * stades de la maladie figo i, ii, iiia et iiic * chirurgie de clôture.

Keywords: ovarian cancer
time-restricted feeding in children and adolescents with obesity

Conditions: Obesity, Childhood; Obesity, Adolescent

Summary: this study will evaluate the effectiveness of a 2-month time-restricted feeding (trf) intervention in children and adolescents with obesity. the investigators will determine whether the potential beneficial effects of the intervention in this population are maintained over time. furthermore, potential mechanisms mediating trf effects will be explored, specifically focusing on the potential role of the gut microbiome and the circadian rhythm.


Eligibility criteria:
inclusion criteria: * obesity (bmi z score \> 2) exclusion criteria: * bariatric surgery * spontaneous time-restricted feeding for \> 12 hours * diabetes with insulin treatment * pregnancy * intellectual disability * under drug treatment with a prescription change in the last 3 months

Keywords: obesity time restricted feeding
effect of chinese traditional medicine for post revascularization treatment of coronary artery disease

Conditions: Percutaneous Coronary Artery Intervention; Coronary Artery Bypass Graft; Acute Coronary Syndrome

Summary: the purpose of this study is to built the standard of chinese traditional medicine test for post percutaneous coronary artery intervention and coronary artery bypass graft，also for acute coronary syndrome，according to the multi-site、random large sample test.


Eligibility criteria:
inclusion criteria: * age40～75 * angina or cad patient * deficiency of heart-qi and blockage of phlegm and blood stasis in chinese medicine * 1 week after operation，or 1week after drainage tube extraction for cabg * sign a informed consent exclusion criteria: * severe cardia failure * severe renal inadequacy * complicating with malignant tumor,reactive alimentary tract hemorrhage and haematological systemic disorder etc. * psychotic * pregnant,lactation

Keywords: percutaneous coronary artery intervention coronary artery bypass graft acute coronary syndrome
diagnosis and treatment planning in patients suspected of having lung cancer

Conditions: Lung Cancer

Summary: rationale: diagnostic procedures and treatment-planning systems may affect outcome in patients suspected of having lung cancer. purpose: randomized diagnostic trial to compare the effectiveness of two types of diagnostic and treatment-planning systems in patients who are suspected of having lung cancer.

objectives: i. compare the survival rate of patients with suspected lung cancer when diagnosed and managed using the conventional locally based approach versus a new centralized system using a 2 stop diagnosis. ii. compare the resection rate in both diagnostic arms. iii. assess the quality of service given in both diagnostic arms. outline: this is a randomized study. patients present to a general practitioner where they are referred to the local chest clinic. patients are seen by the chest physician and, if deemed eligible, are randomized between 2 diagnostic arms. arm i (conventional locally based diagnosis): patients undergo bronchoscopy and ct scan as appropriate, and then are discussed or referred by individual chest physicians, as is the current practice. the optimal period for diagnosis and discussion of management plans is 6 weeks. arm ii (centralized 2 stop diagnosis): patients undergo ct scan the following monday morning. the consultant radiologist advises the most appropriate diagnostic test (e.g., bronchoscopy or percutaneous needle biopsy) to be done that same monday. a tissue diagnosis is available thursday morning for the multidisciplinary meeting attended by the chest physician, medical and clinical oncologists, and a surgeon, and the patient treatment plan is decided. quality of life is assessed at baseline and at 6 weeks. patients are followed for 2 years. projected accrual: a total of 252-315 patients will be accrued for this study within 2 years.

Eligibility criteria:
disease characteristics: possible diagnosis of lung cancer fit enough for bronchoscopy and ct scan patient characteristics: age: not specified performance status: not specified life expectancy: not specified hematopoietic: not specified hepatic: not specified renal: not specified prior concurrent therapy: not specified

Keywords: stage i non-small cell lung cancer stage ii non-small cell lung cancer limited stage small cell lung cancer
osteopathic manipulation therapy in the treatment of interstitial cystitis

Conditions: Interstitial Cystitis

Summary: as a safe and noninvasive method of treatment, the intent of the study is to show that osteopathic manipulation therapy is a beneficial treatment for the aggravating bladder symptoms seen in all patients with interstitial cystitis.

the management of interstitial cystitis is predominantly based on the reduction of the symptoms of frequency, urgency, and pain.in addition to osteopathic manipulation other conservative treatments frequently include dietary modification, pharmaceuticals, bladder training, neuromodulation, and stress reduction. the goal of osteopathic manipulation is to relax the pelvic muscles used by the bladder and improve the flow of blood and lymph fluid to this region, which may result in easing pain and discomfort associated with cystitis.some physicians have found that osteopathic manipulation works for some people as an alternative to surgery. a secondary objective will be to determine if the increased attention and power of touch are as effective as omt in treating patients with interstitial cystitis based on the results of using attention control treatment in some patients.thus, this is a pilot study comparing omt to an attention control arm and standard of care arm of treatment.we will review palpatory visceromatic reflex changes as documented by tissue texture changes, asymmetry, restriction of motion and tenderness pre and post treatment.physical examination including detailed musculoskeletal examination of the lumbosacral region will be performed pre and post and then compared the results.

Eligibility criteria:
inclusion criteria: * the criteria for treatment is that the patient must exhibit symptoms of ic for at least one year and have a known diagnosis based on history and clinical findings including glomerulations of the bladder wall seen on cystoscopic examination. exclusion criteria: * patients who are not eligible are those who have contraindications to omt such as hypersensitivity to palpation, indurations or mass/tumor, adenopathy, cancer, or local infection

Keywords: osteopathic manipulation
the reminder4care program for older adults supported by residential and daycare facilities

Conditions: Dementia Risk Factors; Prevention; Cognitive Health

Summary: dementia incidence is rising, posing a public health challenge, but 45% of cases can be prevented by addressing modifiable risk factors. multidomain trials show that lifestyle changes can improve cognitive function and reduce dementia risk (like the finger trial). the reminder program, a portuguese-based dementia risk reduction protocol, was developed for community-dwelling older adults aged 55 and above. however, older adults in residential and daycare facilities (rdf) have distinct needs that demand program adaptation to ensure its relevance and effectiveness. in addition, more studies are needed to evaluate the impact of multidomain interventions with older adults in rdf. to address these challenges, the reminder4care program was developed as a tailored, multidomain intervention to reduce dementia risk. it emphasizes social and cognitive engagement and advances its adaptation and evaluation in residential and daycare facilities (rdf). to assess efficacy, the investigators will perform a randomized controlled trial.


Eligibility criteria:
inclusion criteria: * aged 65 years and older * rdf users * elementary reading and writing skills exclusion criteria: * have a clinical diagnosis of dementia and/or mini-mental state examination (mmse) scores below the cutoff for the presence of dementia (mmse \< 22-27, depending on education level) * have a psychiatric or neurological condition that impairs cognition in the long term * have sensory and functional deficits that compromise their participation in the neuropsychological assessment and throughout the intervention sessions

Keywords: dementia risk factors prevention health aging residential and daycare facilities lifestyle
a comparison between the aysis® cs2 (general electrics) ventilator in etcontrol® mode and the perseus® a 500 (dräger) in vaporview® mode on maniability and consumption of desflurane

Conditions: Anesthetics Agent; Consumption; Inhalation; Desflurane

Summary: the aysis® cs2 ventilator offers an automated control of end-tidal inhalation anesthetic concentration, the etcontrol® mode. a low fresh gas flow (fgf) (0.5l/min) is kept during the maintenance of the anesthesia, decreasing the expensive consumption of halogenated agents. the perseus® a 500 offers a vaporview® mode that gives the evolution of inspired (fi) and end-tidal (fe) fractions of halogenated agents for 20 minutes based on the delivered fraction (fd). fgf remains adjusted manually by the practitioner. this mode also makes it possible to maintain a low fgf (0.5 l/min), provided the halogen fd is set to maintain a steady fe curve. the goal of this work was to compare the maniability of the intraoperative administered concentrations and the consumption of desflurane between these 2 modalities of administration.


Eligibility criteria:
inclusion criteria: * patients undergoing a general anesthesia for intra abdominal surgery during more than one hour * asa 1or 2 exclusion criteria: * contraindication to halogenated agent * thoracic surgery * no french speaking
study of pre-operative combination therapy with mogamulizumab and nivolumab against solid cancer patients

Conditions: Gastric Cancer; Esophageal Cancer; Lung Cancer; Renal Cancer; Oral Cancer

Summary: to assess the safety of preoperative combination therapy with kw-0761 (anti-ccr4) and ono-4538 (anti-pd-1). to assess the behavior of immune cells in peripheral blood and tumor.


Eligibility criteria:
inclusion criteria: * patients who enable to have standard operation * patients who refuse standard preoperative chemotherapy and are diagnosed with following cancers; gastric adenocarcinoma, esophageal squamous cell carcinoma, non-small-cell lung carcinoma, renal cell carcinoma or oral squamous cell carcinoma * patients with eastern cooperative oncology group (ecog) performance status 0 or 1 * patients with no serious disorder of major organs (born marrow, heart, lung, liver and kidney) * patients with written informed consent * patients who have measurable target lesion * patients who are enable to undergo biopsy for sampling tumor tissue exclusion criteria: * known or previous autoimmune disease * known or suspected interstitial lung disease (ild) * patients with history of serious anaphylaxis induced by antibody preparation * uncontrollable hypertension * uncontrollable endocrine disease * patients who have active inflammatory bowel disease or other serious gi chronic conditions associated with diarrhea * uncontrollable diabetes * prior therapy with sustained anticancer agents, radiotherapy or surgery for primary disease * pregnant or lactating females, female and male patients who cannot agree to practice the adequate birth control after the consent during the study * known or suspected infection or inflammatory disease * prior therapy with hematopoietic stem cell transplantation * known or suspected central nervous system (cns) involvement