Kornimate/medical-research-clean huggingface dataset:
impact of walking behind the copd patient on 6mwd

Conditions: COPD

Summary: the six-minute walk test (6mwt) is a well established field exercise test to assess the functional exercise capacity in chronic obstructive pulmonary disease (copd). the objective of this study is to assess the impact of walking behind the patient on 6mwt distance in patients with copd.

in a single-center, randomized crossover study, the investigators aim to elucidate whether there is a difference in the 6mwt distance when the assessor walks behind the patient compared to the patient walking alone. patients with copd referred for pulmonary rehabilitation will be invited to perform an accompanied 6mwt (assessor walks behind the patient) and unaccompanied 6mwt (assessor does not walk behind the patient) in random order. the tests will be performed at the end of a pulmonary rehabilitation program, after patients are familiarised with the 6mwt testing procedure and learning effects can be excluded.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of copd according to gold ii-iv (fev1/fvc \< 0.7, fev1%norm \< 80%) exclusion criteria: * inability to perform a 6mwt when arriving at the clinic (e.g., lower limb joint surgery within preceding 3 months, unstable cardiac disease, predominant neurological limitations) * inability to understand the instructions of the 6mwt, either of language or cognitive reasons

Keywords: six minute walk test field test exercise capacity functional capacity
papillary thyroid cancer and central lymp node dissection

Conditions: Papillary Thyroid Cancer

Summary: papillary cancer is a disease that spreads through lymphatic ways and its treatment is surgery. we performed prophylactic central dissection in addition to bilateral total thyroidectomy in patients with bethesda 5 and bethesda 6 biopsy results. we evaluated the pathology results retrospectively.


Eligibility criteria:
inclusion criteria: - b5 and b6 biopsy results exclusion criteria: - lobectomy

Keywords: papillary thyroid cancer
health related quality of life in functional dyspepsia

Conditions: Dyspepsia

Summary: previous studies reported health related quality of life impairment in functional dyspepsia patients. anxiety, depression, disease severity, age, and employment status associated with hrqol in functional dyspepsia patients. however, data about hrqol in asian population was limited.this study aimed to evaluate factors associated with health related quality of life in patients with functional dyspepsia.

126 functional dyspepsia patients will answer sf-36 hrqol questionnaire, hospital anxiety, and depression scale, and short form nepean dyspepsia index. functional dyspepsia and irritable bowel syndrome rome iii diagnostic questionnaire and gerd-q questionnaire will be used to determine fd type and ibs or gerd overlap.

Eligibility criteria:
inclusion criteria: * dyspepsia patients * normal or non ulcer esophagogastroduodenescopy finding exclusion criteria: * history of gi bleeding * history of gi malignancies * hepatobiliary tract disease * diabetes mellitus * chronic kidney disease

Keywords: dyspepsia health related quality of life
gamification in the treatment of spider phobia

Conditions: Spider Phobia

Summary: mobile applications are more and more considered when implementing programs for treating mental disorders. the study aims to reduce avoidance and fear of spiders in spider-fearful individuals by combining exposure principles with gamification elements (e.g. narrative background, level progression, points, feedback). we investigate the efficacy of the gamified app in a remote online-therapy context.


Eligibility criteria:
inclusion criteria: participants must * be 18 years or older, * spq score ≥ 14 * bdi-ii score ≤ 18 exclusion criteria: participants will be deemed ineligible if they do not meet the above inclusion criteria or * are allergic to spiders or bee stings, * are currently undergoing psychotherapeutic and/or psychopharmacological treatments, * are experiencing current psychosis, mania, or substance abuse, or * successfully complete 8 or more of 12 possible bat steps at baseline (to ensure that participants are indeed spider fearful) * are at higher risk from covid-19 or * participated in a pilot study in 2019.

Keywords: gamification anxiety disorder avoidance app
using bluetooth home blood pressure monitors with pharmacist interventions

Conditions: Hypertension

Summary: family medicine patients with uncontrolled hypertension will be given a bluetooth enabled home blood pressure machine to monitor their blood pressure every day for 6 weeks. the blood pressure results will be sent automatically to the patient's electronic medical record via applications on their iphone. study pharmacists will follow-up with the patients once per week via a telehealth appointment using the app vsee, where the blood pressure results will be reviewed. the pharmacists will also counsel the patients on lifestyle modifications in order to improve blood pressure.


Eligibility criteria:
inclusion criteria: * must be at least 18 years old * have a smartphone compatible with the mobile intervention (iphone) * have been previously diagnosed with hypertension * have uncontrolled hypertension (sbp \> 130 mmhg and/or dbp \> 80 mmhg) * be under the care of a primary care physician in the family medicine department of the usf morsani center for advanced care * have had at least one prescription filled at pharmacy plus within the last six months * speaks english fluently exclusion criteria: * already under the care of a clinical pharmacist in the family medicine department * pregnant * have a serious existing medical condition(s) that may affect their ability to self-monitor their blood pressure (for example, stroke, dementia)
amiodarone for the prevention of reperfusion ventricular fibrillation

Conditions: Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery

Summary: this was a prospective, randomized, double blinded study in which patients undergoing a cardiopulmonary bypass (cpb) with aortic cross clamping were randomly assigned to receive amiodarone, lidocaine, or saline placebo prior to removal of the aortic cross clamp. (cpb is a technique that temporarily takes over the function of the heart and lungs during surgery, maintaining the circulation of blood and the oxygen content of the body.) specifically, we will test the hypothesis that amiodarone is superior to both lidocaine and placebo in the prevention of a severely abnormal heart rhythm when the blood flow is restored to the heart after the aortic cross clamp is removed.

this was a prospective, randomized, double blinded study in which patients undergoing cardiopulmonary bypass with aortic cross clamping were randomly assigned to receive amiodarone, lidocaine, or saline placebo prior to removal of the aortic cross clamp. specifically, we will test the hypothesis that amiodarone administration decreases the incidence of ventricular fibrillation, the number of defibrillation attempts and the total energy and current required for defibrillation should ventricular fibrillation occur.

Eligibility criteria:
inclusion criteria: * patients undergoing cardiac surgery that was expected to include cross-clamping of the aorta exclusion criteria: * women wishing to become pregnant within 6 months of surgery * allergy to amiodarone * history of organ dysfunction due to previous amiodarone use * patients who require more than mild systemic hypothermia (\<32 degrees c) during cardiopulmonary bypass * patients who require more than one bypass run or more than one period of aortic cross-clamping

Keywords: cardiopulmonary bypass reperfusion ventricular fibrillation ventricular fibrillation amiodarone lidocaine cardiac surgery
efficacy of mutilayered fresh amnoitic membrane transplantation in resistant fungal keratitis

Conditions: Keratitis

Summary: corneal infection or infectious keratitis (ik) is the most common cause of corneal blindness worldwide, particu-larly in the developing countries1. the incidence was estimated at 2.5-799 per 100,000 population/year. it is a painful and potentially blinding ocular emergency that often requires hospital admission for intensive medical and/or surgical treatment. depending on the geographical and temporal variations and population-based risk factors (e.g. agricultural practice, trauma, use of contact lens and others), bacteria and fungi have been shown to be the main causative microorganisms for ik, followed by viruses, parasites and polymicrobial infection. amniotic membrane (am) is the innermost layer of the placenta, which consists of a single layer of meta-bolically active epithelium, a thick basement membrane, and an avascular stromal matrix (15). it has been shown to exhibit a wide array of biological properties, including wound healing, anti-inflammatory, antimicrobial, and anti-angiogenic properties, amongst others. to date, a number of studies have evaluated the benefit of amt for treating active ik, though the majority of them were of small case series or case reports. in clinical practice, amt is usually reserved as a second-line therapy in ik, mainly to promote cornea healing in non-healing ulcer after the sterilization phase.


Eligibility criteria:
inclusion criteria: * size more than 5 mm. * deep ulcers i.e. \> 50% stromal thickness. * located within 3mm of the visual axis. * patients with descemetoceles and corneal perforations will also be included exclusion criteria: * corneal ulcers of size \< 5mm depth \< 50% * associated glaucoma * associated chronic dacryocystitis * ulcers with entropion
a study of the empower program for latinx caregivers of icu patients

Conditions: Informal Caregiver

Summary: the researchers are doing this study to find out whether empower (enhancing \& mobilizing the potential for wellness \& emotional resilience) may reduce emotional distress in latinx caregivers of patients in the icu.


Eligibility criteria:
inclusion criteria: * informal caregivers of patients, who were admitted in an icu or step-down unit during their current admission/stay or within 2 weeks of discharge from their last admission/stay. * informal caregivers listed as a designated health care proxy or decision-making patient surrogate by icu medical staff. * age 18 years or older as per self-report. * residing in new york or new jersey as per self-report or able to complete modules while complying with current telehealth regulations. * spanish-speaking as per the spanish language assessment items below and willing to receive the intervention in spanish. * what is the participant's preferred language? * (specify lang)___________________________ * how well does the participant speak spanish? * very well (participant is eligible) * well (participant is eligible) * not well (participant is not eligible) * not at all (participant is not eligible) exclusion criteria: * informal caregivers who score low, moderate or high on the columbia suicide severity rating scale.

Keywords: empower program latinx caregivers icu patients 22-141
study of alimta and epirubicin administered in patients with locally advanced or metastatic breast cancer

Conditions: Breast Cancer

Summary: this is a non-randomized phase 2 portion of a study testing alimta and epirubicin in combination for locally advanced or metastatic breast cancer. epirubicin is a well-established drug for the therapy of breast cancer. both alimta and epirubicin have been combined with other drugs but they have not yet been combined with each other. it is expected that the patient will benefit from the different mechanisms of action of the two drugs.


Eligibility criteria:
inclusion criteria: * diagnosis of locally advanced or metastatic breast cancer not amenable to local treatment. * patients must be chemo-naive or have only neoadjuvant and/or adjuvant chemotherapy. * patients must have at least one measurable lesion in an area not previously irradiated. * no chemotherapy at least 4 weeks prior to study enrollment. * signed informed consent from patient. exclusion criteria: * treatment with any drug within the last 30 days that has not received regulatory approval. * serious systemic disorders, including active infection. * significant cardiovascular disease. * pregnancy or breast feeding. * inability or unwillingness to take folic acid or vitamin b12 supplementation.
impact of computer-aided optical diagnosis (cad) in predicting histology of diminutive rectosigmoid polyps: a multicenter prospective trial (abc study).

Conditions: Colonic Adenomatous Polyp

Summary: recently, a cnn-based artificial intelligence (ai) system for polyp characterization has been developed by fujifilm co., tokyo, japan. it works in conjunction with bli system. in the present study we prospectively evaluate whether the evaluation of the endoscopist combined with the cad system output achieve \> 90% accuracy in characterization (i.e. as adenomas or non-adenomas) of diminutive rectosigmoid polyps having histopathology as reference standard. consecutive adult outpatients undergoing elective colonoscopy, in which at least one diminutive (\<5 mm) rectosigmoid polyp is detected are included. during endoscopic procedures all polyps identified by the endoscopist are documented for size, location and morphology. all diminutive polyps are characterized by a three sequential steps process: i) endoscopist prediction: the endoscopist evaluates the polyp by using bli through the basic classification; the confidence level (high vs. low) in histology prediction is recorded; ii) ai prediction: the ai system is switched on and the output of the automatic evaluation is recorded; this outcome is rated as stable or unstable, depending of the consistency over time of the outcome; iii) combined prediction: a final classification is provided by endoscopist in light of the results of the first and of the second step; the confidence level is recorded. all polyps are resected and retrieved in separate jars and sent for pathology assessment. only polyps characterized with high confidence will be included in the per-polyp analysis; the high-confidence characterization rate will be also calculated; the rate of polyps characterized with a cad stable outcome will be calculated. operative characteristics (sensitivity, specificity, positive and negative predictive value and accuracy) in distinguishing adenomatous from non-adenomatous polyps, evaluated with high confidence, will be calculated for each diminutive polyp and for each diminutive rectosigmoid polyp, having histopathology report as reference standard. the post-polypectomy surveillance intervals will be calculated on the basis of polyp histology (reference standard) in all patients according to both usmstf and esge guidelines.


Eligibility criteria:
inclusion criteria: * consecutive adult outpatients undergoing elective colonoscopy, in which at least one diminutive (\<5 mm) rectosigmoid polyp is detected. exclusion criteria: * patients with crc history or hereditary polyposis syndromes or hereditary non-polyposis colorectal cancer * patients with inadequate bowel preparation * patients scheduled for partial examinations * polyps could not be resected due to ongoing anticoagulation preventing resection and pathologic assessment * patients undergoing urgent colonoscopy
acute kidney injury standardized clinical assessment and management plan for renal replacement initiation

Conditions: Acute Kidney Injury

Summary: this study is of a clinical decision support tool for clinicians taking care of patients with severe acute kidney injury in the intensive care unit. nephrologists will be given a standardized clinical assessment and management plan (scamp), which is a tool to assist clinicians in decision making on the need for renal replacement therapy (mendu et al., cjasn 2017). in alternating months, nephrologists will be given the scamp vs. another simplified form. the goal is to test whether patients whose clinicians are asked to fill out the scamp have improved outcomes compared to the control group. the investigators are also collecting information about provider adherence to the scamp and deviations from the scamp recommendations to understand clinical decision making related to renal replacement.

background: acute kidney injury (aki) is common among critically ill patients and is associated with substantial morbidity and mortality. severe aki requiring renal replacement therapy (rrt) is associated with in-hospital mortality rates exceeding 40%. the investigators designed and implemented an aki standardized clinical assessment and management plan (scamp), a decision-making algorithm to assist front-line nephrologists caring for patients with aki. the investigators piloted the implementation of the aki scamp in the medical intensive care unit at brigham and women's hospital prospectively over the course of 1-year, and illustrated that patients whose nephrologists adhered to the scamp recommendations had lower in-hospital mortality. the investigators have a publication in press in the clinical journal of the american society of nephrology detailing our findings (mendu et al. cjasn january 2017). aims: the primary aim of this study is to expand the prospective implementation of the aki scamp to multiple intensive care units (icus) at brigham and women's hospital in an interrupted time series study (nephrologists will be asked to complete the aki scamp alternate months). the investigators aim to test the hypothesis generated by our pilot study, that the utilization of an aki scamp by providers in a critical care setting can reduce in-hospital mortality. expanding to multiple icus and introducing a time series design will mitigate the limitations of our pilot data, such as a small sample size and confounding by disease severity. design: the investigators seek to conduct a prospective interrupted time series study of the implementation of an aki scamp utilized by nephrologists in intensive care units during the time period of 1 year to determine if utilization of the aki scamp reduces in-hospital mortality.

Eligibility criteria:
inclusion criteria: * acute kidney injury, followed by nephrology consult service * intensive care unit exclusion criteria: * end stage renal disease * renal replacement therapy for advanced chronic kidney disease rather than acute kidney injury.
cardiac arrest : brain oxymetry depending on hypothermia depth

Conditions: Cardiac Arrest

Summary: cardiac arrest is a major public health problem, with 700 000 cases per year , and a survival ranging from 4 to 33%. the post- anoxic encephalopathy remains the most serious complication with only a third of survivors . it is due to a series of phenomena involving microcirculation disorders . cerebral oximetry is a new technique to evaluate the microcirculatory status . to this day it is used in cardiovascular surgery at risk of cerebral hypoperfusion where desaturation of cerebral oximetry is synonymous with ischemia and microcirculatory disorders. therapeutic hypothermia is the only treatment improves the outcome of patients after extra- hospital cardiac arrest resuscitation . its mechanisms of action seem to change all the phenomena responsible for microcirculatory reperfusion disorders . currently it is recommended to practice hypothermia between 32 and 34 ° c. however, a recent study suggests a superiority of hypothermia at 32 ° c rather than 34 ° c. the hypothesis of this study is that cerebral oximetry value will be different in patients subjected to two different levels of therapeutic hypothermia in the aftermath of an extra- hospital cardiac arrest. these data allow a better understanding of the mechanisms underlying the benefit of this technique.


Eligibility criteria:
inclusion criteria: * patient presented with an extra-hospital cardiac arrest resuscitation and to benefit from therapeutic hypothermia using a servo system to its temperature (coolgard 3000 ® system) * age\> 18 years and \<80 years exclusion criteria: * major patient protected by law * private person administrative or judicial freedom * neurological or traumatic cause of cardiac arrest * pregnancy

Keywords: cardiac arrest oxymetry hypothermia
exploratory study on the s-1 + paclitaxel chemotherapy for unresectable gastric cancer

Conditions: Surgically-Created Resection Cavity; Drug Safety

Summary: exploratory the s-1 + paclitaxel chemotherapy for creating the operation chance in the patients with unresectable gastric cancer

to assess the effectiveness and safety of s-1 + paclitaxel for the peri-operative chemotherapy in chinese patients with unresectable gastric cancer, so as to further find out the optimal protocol for the peri-operative chemotherapy in the patients with gastric cancer.

Eligibility criteria:
inclusion criteria: -unresectable gastric cancer as proven histologically (ajcc, version 7) under any following condition: unable radical excision due to the local metastasis or invasion metastasis to the lymph node beside the abdominal aorta non-extensive metastasis to liver (not more than three metastatic foci of radical excision) * definitely diagnosed as above stage of stomach cancer before the operation via ct or mri, ultrasonic endoscopy and blood tumor antigen test, or through the laparoscopy if necessary * untreated (e.g. radiotherapy, chemotherapy, target therapy and immunotherapy) * ecog (eastern cooperative oncology group) : 0\~2 * age: 18\~75 years old * normal hemodynamic indices before the recruitment (including blood cell count and liver/kidney function). for example: wbc\>4.0×109/l, neu \>1.5×109/l, plt\>100×109/l, bil\<1.5 times of upper limit of normal reference value, alt and ast\<2.5 times of upper limit of normal reference value, and cre\<1.2mg/dl * good cardiac function before the recruitment, no seizure of myocardial infarction in past half year, and controllable hypertension and other coronary heart diseases * not concomitant with other uncontrollable benign diseases before the recruitment (e.g. the infection in the lung, kidney and liver) * not participating in other study projects before and during the treatment * signed the informed consent form exclusion criteria: * not conforming to above inclusion criteria * distal metastasis to lung, brain and bone (except the liver) * ever operation on the stomach * operation intolerance due to other systemic basic diseases * ever administered other drugs (including tcm drugs) before the recruitment, or no guarantee of progress according to the study requirement after the recruitment * allergy to the drugs in this protocol * pregnant or lactating women * women at childbearing age and of pregnancy desire during the study