Kornimate/medical-research-clean huggingface dataset:
prct: ligament reconstruction & tendon interposition with a joint spacer for trapeziometacarpal oa

Conditions: Joint Disease

Summary: the purpose of this study is to compare the effectiveness of two types of operative treatment in terms of resolving symptoms, improving function and also with respect to x-ray outcomes. the hypothesis is that insertion of a spacer will provide similar symptomatic relief, but improved long term gains in key and tripod pinch strength when compared to lrti.

trapeziometacarpal (tmc) arthritis is a common condition, which occurs when the cartilage (tissue) covering the bones at the joint at the base of the thumb wear away. this condition occurs in 10% of women and 1% of men. there is controversy regarding the best treatment of this condition and many surgical techniques are in common use. one of these involves removing the wrist bone (trapezium) at the base of the thumb and, using a tendon from the forearm, reconstructing an important ligament, which contributes to the stability of the thumb. this is known as a ligament reconstruction and tendon interposition (lrti). a newer type of operation involves the insertion of a ascension pyrodisk which is made from a thick pyrocarbon layer encasing a graphite core with a small amount of tungsten. these materials have been shown to be safe when implanted in the body. the pyrodisk is a disk shaped design which has a curved surface designed to fit between the bony surfaces of the trapezium and the metacarpal, reducing pain and allowing for full movement of the joint. it contains a hole in the center through which a strip of tendon can be passed and helps hold the disk in place. this research study is designed to determine the effectiveness of the ascension pyrodisk spacer when compared to the lrti procedure described above. the effectiveness of both of these procedures will be determined by comparing range of motion, grip and pinch strength, x-rays, function and return to work. it is important to compare both procedures, as it is not known which procedure is the most effective.

Eligibility criteria:
inclusion criteria: * isolated trapeziometacarpal osteoarthritis * duration of symptoms of at least six months * failure to respond to non-operative management * age 50 or older * less than 30 degrees of ipsilateral mcp hyperextension * british columbian resident living in the lower mainland and available for protocol follow-up exclusion criteria: * previous surgery for tmc arthritis * other significant ipsilateral wrist or hand pathology * a history of inflammatory arthropathy * a requirement for concommitant surgery for another condition * any previous hand or wrist fracture

Keywords: randomized prospective procedure / surgery
fluorine-18-α-methyltyrosine positron emission tomography (18f-fmt pet) for therapy response in lung cancer

Conditions: Non-Small Cell Lung Cancer

Summary: l-\[3-18f\]-α-methyltyrosine (18f-fmt) is an amino-acid tracer for positron emission tomography (pet). the investigators evaluated the value of 18f-fmt pet for the assessment of therapy response in patients with lung cancer as compared with that of 2-\[18f\]-fluoro-2-deoxy-d-glucose (18f-fdg) pet. the patients with lung cancer underwent pet studies with 18f-fdg and 18f-fmt before and after radio-/chemotherapy. the investigators used the ratio of the suvmax of the mediastinal (n2) lymph node to the suvmax of the primary tumor (n/p ratio ). all patients were divided into two groups of n/p ratio\<1 and n/p ratio≥1, and the survival time was estimated by kaplan-meier method.


Eligibility criteria:
inclusion criteria: * primary lung cancer all patients received first-line chemotherapy exclusion criteria: * patients with diabetus mellitus

Keywords: fluorine-18-α-methyltyrosine positron emission tomography lung cancer chemotherapy monitoring
the use of narrative in public health research and practice: patient experience of wellness acupuncture

Conditions: Pain; Depression; Fatigue

Summary: this study examined the experiences of individuals undergoing acupuncture to gather information on patient-provider communication and on the therapeutic effects of acupuncture.

authentic voice is a approach involving the use of first-hand narratives from members of a target population in order to accomplish public health goals. in the first paper, a discussion of the potential of using narratives from the target population as 1) a direct intervention; 2) a form of persuasive communications; and 3) a source of information for research into various topics. the main premise is that traditional narrative methods can be adapted to the public health context by providing the narrator with the topic of the narrative. the second paper examines the patient experience of acupuncture using narrative drawn from interviews with and letters from acupuncture patients using a content oriented approach. the third paper examines the importance of meaning shift over the course of acupuncture treatment and demonstrates the usefulness of patient narratives as a data source for examining meaning. findings include the need for intervention studies comparing authentic voice approaches to existing health communication tools for effectiveness in creating attitude and behavior change efficiently. authentic voice approaches also need to be researched to understand and systematize concepts such as validity in relation to target-group derived narratives. effectiveness of authentic voice for advocacy and research should also be further tested. concerning acupuncture, the second and third papers show that acupuncture patients report a variety of benefits far wider than previously reported in the literature. study designs should consider this wide range of benefits when assessing acupuncture outcome. meaning shift is also reported by acupuncture patients and may play an important (but non-specific) role in the healing associated with acupuncture.

Eligibility criteria:
inclusion criteria: * individuals seeking acupuncture from private practice in baltimore/washington metro area. exclusion criteria: * prior patients

Keywords: acupuncture patient narratives qualitative methods
single-use versus multiple-use endoscopes in gastroenterology

Conditions: Endoscopy, Gastrointestinal

Summary: gastroenterology is a branch of medicine that looks after people with problems in the gut (including the stomach and bowels) using an endoscope. an endoscope is a thin tube with a light and camera at the end, which is used to look inside bits of the body, for example the stomach, bile ducts (tubes that connect the liver and gallbladder to the bowel) or large bowel. some have extra bits attached to take samples of tissue to look at under a microscope. these tubes are made mostly of plastic. around 1.5 million endoscopies are performed each year in the uk. in the nhs, most endoscopes are re-usable and are used hundreds of times after cleaning and disinfection. they must be very carefully cleaned and disinfected to reduce the risk of passing on infections to other patients as well as the healthcare staff who use the equipment. if endoscopes are cleaned and disinfected properly, the risk of infection will be very low. however there have been reports of infections, which may be related to disinfection not being done properly. disposable single-use endoscopes are now available, designed to reduce the risk of infection. these are thought to be just as good as re-usable endoscopes. however, if we switch to disposable endoscopes, it may increase the cost to the nhs. there will also be an effect on the environment from using limited resources to make endoscopes, and get rid of them by incineration (burning) or burial in landfill waste. the aim of this research is to provide evidence on the arguments for and against the use of single-use vs. multiple-use endoscopes in gastroenterology for nhs decision makers, especially regarding cost-effectiveness and effect on the environment. this will help the aim of the nhs in england to be "the world's first 'net zero' national health service.


Eligibility criteria:
inclusion criteria: patients * over the age of 18 * patient has been invited to an nhs endoscopic clinic to undertake an upper gi endoscope procedure, including diagnostic endoscopies and the less complex therapeutic endoscopy. * patient is able to read and understand information provided * patient has capacity to provide consent * patient is able to participate in an interview. staff * over the age of 18 * employed by the nhs * working in relevant endoscopy unit - primary work involves the conduct of endoscopy and/or waste disposal services (decontamination or disposal). exclusion criteria: * patient has received a lower gi endoscopy, e.g. colonoscopy or sigmoidoscopy * non-nhs service providers and receivers. (e.g., private diagnostic clinics)
sevoflurane sedation on intra cranial pressure in traumatic brain injury patients

Conditions: Brain Injury

Summary: main purpose of the study is to evaluate the effect of sevoflurane on intra cranial pressure (icp) after traumatic brain injury. patients admitted for traumatic brain injury equipped with icp measurement will be sedated with sevoflurane via the anaconda device during 12 hours. sedation will be controlled with bis.

sedation is most of the time required for icp management after traumatic brain injury. sevoflurane, an inhaled anaesthetic drug is commonly used in operatory room. thanks to a new device, the anaconda, it now can be applied to intensive care patients. his advantages a rapid elimination after administration stops, which can allow an early neurologic evaluation, very important for traumatic brain injury patients.we will study the effect of sevoflurane administration on icp of tbi patients. patients admitted for severe tbi (glasgow come scale \< 8), equipped with icp sensor, elder than 18 years old will be include. a sedation with sevoflurane will be administrated during 12 hours instead of classical intra venous sedation with midazolam, depending on bis score. icp evolution will be characterised in success if \< 30 mmhg or failure if ≥ 30 mmhg.6 patients will be included for the first phase. the study will be stopped if the failures are ≥ 2. otherwise, 27 patients will be included. study will be stopped if failures number ≥ 5 before the end if the inclusion period.

Eligibility criteria:
inclusion criteria: * severe traumatic brain injury (glasgow \< 8) * age \> 18 * no surgery scheduled * sedation with midazolam and sufentanil * icp sensor exclusion criteria: * external ventricular derivation * pregnancy * antecedent of malign hyperthermia * haemodynamic instability

Keywords: sevoflurane brain injury intra cranial pressure sedation brain injury with initial glasgow score less than 9
a multi-centre trial on targeted microwave ablation (tma) for localized prostate cancer

Conditions: Prostate Cancer

Summary: this study is to investigate the efficacy of targeted microwave ablation (tma) under mri-ultrasound fusion and organ-based tracking (obt) navigation in localized prostate cancer (pca) in a multi-centre trial.

this is a prospective multi-centre trial in 5 hospitals in 3 countries to investigate the efficacy and complications of targeted microwave ablation as a minimally invasive focal therapy for prostate cancer. men aged 50-75 with psa \< 20ng/ml and clinically significant prostate cancer with 1-2 mri lesions ≤15mm and isup grade group ≤3 will be recruited. transperineal targeted microwave ablation of the prostate tumor(s) will be done with repeated ablations by a single microwave needle guided by mri-ultrasound fusion and organ-based tracking navigation. the primary outcome is any clinically significant prostate cancer detected on biopsy of treated area(s) per patient at 6 months.

Eligibility criteria:
inclusion criteria: 1. men aged between 45 - 75 years 2. life expectancy \> 10 years upon recruitment 3. able to understand the trial and can provide informed and written consent, dated and signed before the enrollment and before any exam required by the trial 4. localized low or intermediate risk prostate cancer diagnosed on mri-ultrasound fusion targeted biopsy 5. organ-confined prostate cancer on mri 6. psa \< 20 ng/ml 7. 1-2 mri visible lesion present and size ≤15mm, with targeted biopsy showing: * isup grade group 2 or 3, or * isup grade group 1 with tumor size ≥10mm exclusion criteria: 1. patients not fit for general or spinal anaesthesia 2. patients unfit for mri exam or mr gadolinium contrast (e.g. estimated glomerular filtration rate (egfr) of \<50 ml/min) 3. patients with coagulopathy that cannot be corrected 4. patients on anticoagulants or antiplatelets that cannot be stopped (low dose aspirin, e.g. 80-100mg, is acceptable and no need to stop before or during tma treatment) 5. patients with previous treatment of prostate cancer 6. patients with prior pelvic radiotherapy for prostate cancer or other cancer 7. patients with maximal length of target lesion \>15mm 8. patients with mri-visible or invisible lesion within 10mm from rectum or 10mm from sphincter on mri 9. . patients with \>2 areas (mri-visible or invisible) of prostate cancer 10. patients with gleason score 4+4 or any gleason pattern 5 cancer 11. patients with systematic cores showing any gleason 4 pattern pca which are not adjacent to the target lesions (1 core of pure gleason 3 pattern pca on systematic cores in contralateral lobe is acceptable) 12. patients with definite ct3 or above disease on imaging (prostate capsular contact without definite extra-capsular extension is acceptable) 13. patients with bladder pathology including bladder stone and bladder cancer 14. patients with known urethral stricture 15. patient with a suspected covid-19 disease or an active sars-cov-2 infection.
intraoperative imagery of renal nodules with folate-fluorescein conjugate(ec17)

Conditions: Renal Cell Carcinoma

Summary: according to the national cancer institute, an estimated 64,770 men and women will be diagnosed with kidney cancer in 2012. of this number, an estimated 13,570 will die of this disease. surgery remains one of the best options for patients presenting with operable stage ii or iii cancers, however the five year survival rate for these candidates remains at a dismal 63.7% for stage ii and 11% for stage iii. the high rates of recurrence suggest that surgeons are unable to completely detect and remove primary tumor nodules in a satisfactory manner as well as lingering metastases in sentinel lymph nodes. by ensuring a negative margin through imaging during surgery it would be possible for the investigators to improve the rates of recurrence free patients and thus overall survival. renal cell malignancies are the ideal disease to investigate intra-operative imaging. 70% of kidney malignancies express folate receptor alpha (fra). it is important to note that fra is expressed only in the proximal tubules of the kidneys, activated macrophages, and in the choroidal plexus. thus, the false positive detection rate is expected to be extremely low. a group well known to us in the netherlands has completed a pilot study utilizing a folate-fitc conjugate in 12 patients with ovarian cancer. another group of investigators in mayo have subsequently performed this study on 20 more patients without any serious adverse events (personal communication). they report excellent sensitivity and specificity with this technique with only grade 1 side effects (allergic reaction). all side effects reversed when the injection was halted. patients with a history of allergic reactions to insect bites should not participate (fluorescein is derived from the firefly insect, folate is an essential vitamin).


Eligibility criteria:
inclusion criteria: 1. adult patients 18 years of age or older 2. patients presenting with a renal cell nodule or mass that are scheduled for open or laparoscopic resection based on clinical criteria 3. good operative candidate 4. subject capable of giving informed consent and participating in the process of consent. exclusion criteria: 1. pregnant women as determined by urinary or serum beta human chorionic gonadotropin (hcg) test within 72 hours of surgery 2. patients with a history of anaphylactic reactions to folate-fitc or insects 3. at-risk patient populations 1. people who would be easily lost to follow-up (ex: people who are homeless or alcohol dependent) 2. children and neonates 3. patients unable to participate in the consent process

Keywords: renal cell carcinoma renal nodules
the observational study of growth hormone-secreting pituitary tumors

Conditions: Acromegaly; Pituitary Tumor

Summary: the major purpose of this study is to evaluate the changes of multiple organs in patients with growth hormone-secreting pituitary tumors before and after surgery. plasma, dna samples and pituitary tumor tissues will be kept for further analysis.

multiple organs or systems will be affected by excessive growth hormones in patients with acromegaly. the major purpose of this study is to evaluate the changes before and after the pituitary surgery.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acromegaly * \> 18 years old

Keywords: acromegaly pituitary tumor
clinical study of an dendritic and glioma cells fusion vaccine with il-12 for treatment-naïve gbm patients.

Conditions: Glioblastoma; Glioma; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms; Neoplasms, Nerve Tissue; Vaccines; Immunologic Factors

Summary: a multi-center, open-label, single-arm, phase i/ii clinical study is designed to test the safety and immunogenicity of an investigational dendritic and glioma cells fusion vaccine given with il-12 for treatment-naïve patients after resection of glioblastoma.

this clinical trail includes two phases: basic treatment phase and immunotherapy phase. in basic treatment phase, patients will receive concomitant radiation and tmz-chemotherapy. in immunotherapy phase, besides maintenance chemotherapy with tmz, fusion cells will be administered with il-12 to enhance the immunity of patients.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years; male or female. 2. treatment-naïve patients after resection of glioblastoma. 3. histologically confirmed glioblastoma. 4. kps ≥ 60 5. white blood cell count (wbc) ≥ 3.0 x 109/l; peripheral blood lymphocyte (pbl) ≥ 25%. 6. echocardiographic assessment of left ventricular ejection fraction (lvef) ≥ 40% within 1 month of enrollment. 7. patients must be able to understand the investigational nature of the study and provide informed consent. exclusion criteria: 1. those who are allergic constitution, or allergic to biological products, or have contraindications to ct and mri1 contrast agents. 2. those with severe autoimmune diseases or immunodeficiency diseases. 3. those who are expected to take systemic corticosteroids within three months. 4. those who needs long-term usage of immunosuppressive agents. 5. those with infectious diseases, including syphilis, aids, hepatitis b, hepatitis c, etc. 6. those who plan to receive any other anti-tumor treatment during the trial. 7. combined with serious primary diseases of cardiovascular, liver and kidney, and liver function (alt, ast, y-gt) exceeding 1.5 times of the upper limit: bun or cr exceeding 1.5 times of the upper limit of normal value. 8. patients with other malignant tumors. 9. those with active infections, etc. 10. suspected or confirmed a history of alcohol and drug abuse. 11. psychiatric illness, intellectual and language disabilities that compromise the informed consent process, at the discretion of the investigator. 12. women who are pregnant or nursing. 13. women of childbearing age who refuse to contraception. 14. active participation in another clinical treatment trials. 15. according to the judgment of the investigator, other conditions that the plan cannot be followed.
pain and mobility in children with sleep bruxism

Conditions: Bruxism, Sleep

Summary: bruxism is defined as a repetitive jaw muscle activity characterized by clenching and grinding teeth caused by mandibular movement. sleep bruxism is frequently seen and can affect the quality of life of individuals. since bruxism is characterized by clenching teeth, it can cause pain. however, the relationship between bruxism and pain has not been sufficiently studied in the literature. the relationship between the temporamandibular joint and the cervical region is known. however, the relationship between bruxism and cervical mobility is not clear. since there may be temporamandibular joint problems in bruxism, it can affect joint movement. the sleep quality of individuals may decrease and this may lead to problems in functionality. however, when the literature is examined, the relationship between bruxism and functional independence in children has not been explained. therefore, the aim of the study was to compare the pain, range of motion, sleep quality and functional independence of children with bruxism and healthy controls.

bruxism is defined as repetitive jaw muscle activity characterized by clenching and grinding teeth caused by mandibular movement. sleep bruxism is frequently seen and can affect the quality of life of individuals. since bruxism is characterized by clenching teeth, it can cause pain. however, the relationship between bruxism and pain has not been sufficiently studied in the literature. in addition, bruxism can cause problems in joint mobility of the cervical region by affecting the activation of muscles. although the relationship between the temporomandibular joint and the cervical region is clearly known, the relationship between bruxism and cervical mobility is not clear. for this reason, sleep problems are frequently seen in individuals. the sleep quality of individuals decreases and can cause problems in functionality. however, when the literature is examined, the relationship between bruxism and functional independence in children has not been explained. since bruxism can reduce the quality of life of individuals due to the indirect effects it causes, it should be seen and evaluated not only as a disorder involving the jaw joint, but as a problem affecting the entire body. therefore, the aim of the study was to compare pain, range of motion, sleep quality and functional independence in children with bruxism and healthy controls.

Eligibility criteria:
inclusion criteria: * having been diagnosed with nocturnal bruxism * having received parental consent to participate in the study * being between the ages of 13-18 * being in good mental condition * being able to understand and follow the instructions in the study * having class 1 occlusion exclusion criteria: * not consenting to participate in the study or withdrawing from the study * not being able to cooperate well * having a history of surgery * having any physical disability or chronic disease * having received dental treatment in the last 6 months