Kornimate/medical-research-clean huggingface dataset:
heat application on gastrointestinal system functions

Conditions: Enteral Nutrition; Gastrointestinal System--Abnormalities

Summary: complications related to the gastrointestinal system can occur in patients receiving enteral nutrition. these complications may include nausea, vomiting, diarrhea, constipation, decreased bowel sounds, abdominal distension, increased gastric residual volume, and abdominal pain. to prevent and treat food intolerance, as well as to increase gastric emptying, the use of prokinetic agents is often preferred. however, these drugs have various side effects, such as abdominal cramps, allergies, bronchospasm, cardiac issues, and pancreatic disorders. one non-pharmacological method that can be applied to increase bowel motility and reduce abdominal distension and constipation is heat application. the aim of this study is to determine the effect of heat application to the abdominal and lumbar regions, using a hot water bag, on gastrointestinal system functions in patients receiving continuous enteral nutrition.


Eligibility criteria:
inclusion criteria: * intensive care unit patients * individuals aged 18 and above * patients receiving enteral nutrition via nasogastric tube * patients on the first day of enteral nutrition * those receiving standard enteral nutrition solution * patients without wounds in the abdominal region * individuals who have not undergone abdominal surgery in the last 6 months * patients not undergoing radiation/chemotherapy * those with a high-output fistula without ileus problems * patients without diarrhea and constipation * patients with a glasgow coma scale (gks) \> 3 * those with an apache ii score \> 16 * patients not taking prokinetic agents * patients not taking laxative medications * patients without any contraindications for the application of heat, such as neuropathy (to be determined in consultation with the primary doctor). exclusion criteria: * patients in whom enteral nutrition is discontinued during the study * patients transitioning to a product other than the standard one in enteral nutrition * patients who temporarily pause enteral nutrition * patients who have started prokinetic agents * the study will be terminated in patients who have started taking laxative medications.

Keywords: enteral nutrition heat application gastrointestinal system functions continuous enteral nutrition
persistence of immune response after vaccination with mcc

Conditions: Prevention of Meningococcal Infection

Summary: persistence of immune response after vaccination with mcc


Eligibility criteria:
inclusion criteria: * healthy adolescents vaccinated with meningococcal c conjugate vaccine exclusion criteria: * ascertained or suspected disease caused by n. meningitidis * household contact with individuals with proven n. meningitidis serogroup c infection * significant acute or chronic infections * any other serious disease

Keywords: prevention of meningococcal meningitis vaccines conjugate immunology antibody persistence
clinical study evaluating the safety of lactobacillus probiotic in children with drug resistant epilepsy

Conditions: Drug Resistant Epilepsy

Summary: animal and human studies have brought up evidence supporting gut microbial disbalance, namely dysbiosis, as a causative factor of epilepsy, especially the refractory form. thus, probiotics might constitute a safe, low-cost, and effective supplementary therapy in patients with dre. the lactobacillus population is probiotic bacteria that have a beneficial role in epilepsy. lactobacillus can influence brain function through the modulation of gaba, as shown in rodent models. moreover, it has been demonstrated in animal models of epilepsy and in human epileptic patients that probiotic treatment aimed at restoring gut microbiota equilibrium has beneficial effects on epileptic symptoms by increasing gaba in animals and the levels of bifidobacteria and lactobacillus in humans.

this study will be a placebo-controlled, double-blind, and parallel 6-month duration study

Eligibility criteria:
inclusion criteria: * patients aged 3-18 years with intractable childhood-onset epilepsy. * all patients are diagnosed to have drug-resistant epilepsy (refractory epilepsy) according to the ilae definition. * the subject is willing and able to comply with the study requirements exclusion criteria: * any metabolic conditions that might increase the risks associated with trial participation or investigational product administration, such as hepatic enzyme elevation greater than twice normal and/or a gfr \< 60 ml/min/1.73 m2 or electrolyte imbalance. * patients who are currently using or used antibiotics therapy in the preceding month * patients who are currently using or used other probiotic products in the preceding two weeks * patients scheduled to undergo git surgery or those who underwent git surgery * patients with a known allergy to probiotics. * patients receiving artificial enteral or intravenous nutrition

Keywords: lactobacillus
the research of human cortex cell atlas

Conditions: Aging; Epilepsy; Trauma, Brain

Summary: in this study, the single-cell transcriptome sequencing technology was used to study the transcriptome differences at the single-cell level in normal human brain, aging human brain, and epileptic brain.

the human brain has about 100 billion cells and makes up neural networks.the abnormal activity of neurons can affect the operation of neural networks, leading to neurological diseases.with the coming of the age of global population aging, neurodegenerative diseases such as alzheimer's, parkinson's and huntington's have become an increasing burden on human health. cells are the basic unit of brain. understanding the mechanism of brain activities includes not only the mechanism of neural network, but also the self-regulation of its basic unit, that is, the regulation of gene expression based on brain activity.the abnormal expression and regulation of genes lead to the abnormal activities of the nervous system.therefore, studying the regulation mechanism of gene expression at the cellular level is an important way to research brain diseases.the recent development of single-cell rna-sequencing technology provides a possibility to understand the functioning mechanism of the brain at the cellular level.

Eligibility criteria:
inclusion criteria: * craniocerebral injury patients needing operative treatment * treatment-resistant epilepsy patients needing resection surgery exclusion criteria: * vital signs unstable * pregnancy * tumor * incomplete medical history, imaging and clinical diagnosis

Keywords: single-cell analysis aging epilepsy trauma brain
effectiveness of tongue resistance exercises on tongue and swallowing function in frail older adults with mci

Conditions: Mild Cognitive Impairment

Summary: the purpose of this study is to explore the effects of tongue resistance exercises on tongue muscle strength and swallowing function in frail older adults with mild cognitive impairment living in the community. this study adopts a longitudinal research design with randomization. participants were randomly assigned to two groups using an online computer-based randomization tool. the experimental group performed tongue resistance exercises, while the control group practiced cheek bulging exercises.

recruitment took place in nursing homes, day care centers, and community care centers across taiwan. participants were older adults aged 65 years or older with mild cognitive impairment and frailty, enrolled between august 1, 2021, and july 31, 2022. participants were randomly divided into two groups by computer, 23 peoples per group, the experimental group performed tongue resistance exercises, while the control group practiced cheek bulging exercises. the exercise intervention is 12 weeks of exercise begins, with each session 30 minutes. the evaluation items include basic information, outcomes collected through a iowa oral performance instrument (iopi) was used to measure tongue strength, tongue endurance, tongue endurance time, saliva swallowing pressure, effortful saliva swallowing pressure, and aspiration assessment. the measurement times are as follows: t0 (baseline), t1 (week 4, mid-intervention), t2 (immediate post-test after the 12-week intervention), and t3 (follow-up after the 12-week intervention). before conducting the study, all participants received a complete explanation of the purpose, risks, and procedures of the investigation, and provided written informed consent. procedures were in accordance with the ethical standards of the committee on human experimentation at the institution where the work was conducted, and this study was approved by the institutional review board.

Eligibility criteria:
inclusion criteria: * mild cognitive impairment in older adults aged ≥65 years * frailty assessment: at least 1 point exclusion criteria: * having aspiration pneumonia * tracheotomy is retained

Keywords: tongue resistance exercises frail swallowing function
comparing naproxen to sumatriptan for emergency headache patients

Conditions: Migraine; Tension-type Headache; Primary Headache Disorder

Summary: 2/3 of patients discharged from an emergency department after treatment for an acute headache will still be bothered by headache within 24 hours of emergency department (ed) treatment. the goal of this study is to compare two medications, naproxen and sumatriptan, to determine which is better for the treatment of recurrent headache within 24 hours of emergency department discharge.

two-thirds of the five million headache patients who present to us emergency departments (ed) annually are suffering an acute exacerbation of a primary headache disorder. of these acute primary headaches, migraine is the most frequently encountered disease entity in the ed, accounting for 60% of primary headaches, followed by tension-type headaches, which represent 10% of all primary headaches seen in the ed. about ¼ of all acute primary headaches seen in the ed cannot readily be given a specific diagnosis3. multiple parenteral treatments are used to treat acute primary headaches1, but to date, regardless of specific headache diagnosis, no medication eliminates the frequent recurrence of headache after ed discharge. to date, it is unknown which medication patients should be given when discharged from an ed after treatment for a primary headache. this study will compare two oral headache treatments to determine which one relives pain more effectively. specific aims: 1) to determine which of two oral medications is more efficacious for all acute primary headache patients who are discharged from an ed. primary hypotheses: in the 48 hour period following ed treatment for a primary headache, sumatriptan 100mg will relieve pain better than naproxen 500mg, as measured by an 11-point numerical rating scale for pain.

Eligibility criteria:
inclusion criteria: * treated in the emergency department for acute primary headache exclusion criteria: * allergy, intolerance, or contra-indication to one of the study medications

Keywords: emergency department headache migraine
preclinical study towards an immunotherapy in adrenocortical carcinoma

Conditions: Adrenocortical Carcinoma; Cushing's Syndrome

Summary: adrenocortical carcinoma (acc) is a rare and heterogeneous malignancy with poor prognosis. surgical resection of the tumor is the treatment of choice. however, even after complete resection more than 80 % of patients will experience recurrence of disease. therefore, new treatment options are urgently needed. this pre-clinical study try to lay the foundations for a successful immunotherapy in patients with acc.


Eligibility criteria:
inclusion criteria: * patients with histological proven adrenocortical carcinoma * healthy persons as control group * life expectancy \> 6 months exclusion criteria: * autoimmune diseases * severe clinical condition
feasibility and security of a rapid rule-out and rule-in troponin protocol in the management of nstemi in an emergency departement

Conditions: Myocardial Infarction

Summary: management of nstemi in emergency departements represent 10% of the global activity. since the the last european society of cardiology recommendation the use of an 1 hour rule-in and rule-out protocol is recommended combined with high-sensitivity troponin. but studies show 3% of the patients are false negative using this protocol. this study aims at analysing the feasibility of this protocol in an emergency departement and the security of this protocol if combined with a pre-troponin probability score.

chest pain is a frequent reason for consultation in emergency departments. among cardiological causes, quickly diagnosing nstemi optimize patient treatment. to do this, the european society of cardiology, proposed in 2015 an one hour rule-in rule out troponin dosage based protocol. these recommendations should allow a faster diagnosis of nstemi but also a rule-out of patients with a low to moderate clinical probability of coronary heart disease. it could also improve efficiency in emergency departements decreasing the length of stay for patient consulting for acute chest pain allowing use of medical and para medical time for other patients. but the studies on which thoserecommendations are based show up to 3% of false negative, which could lead to a higher mortality rate for those patients even if this issue hasn't been address yet. furthermore, the tight schedule in which a blood sample need to be withdraw, analyzed and taken knowledge of by the doctor could be an obstacle to the feasibility of such protocol in emergency departments usually overwhelmed with patients. the aim of this monocentric prospective study is to assess how a pre-troponin clinical probability of nstemi allowing risk stratification could decrease the false negative rate of this protocol insuring safetiness in its use. the secondary objective is to assess the feasibility of such protocol in an emergency department with high patient flow.

Eligibility criteria:
inclusion criteria: * patient with troponin dosage in a suspected nstemi. exclusion criteria: * under 18 years old * respiratory rate over 30 per min * spo2 under 92% * tachycardia over 110 per min * bradycardia under 40 per min * fever over 38°5c, * anemia under 10 g/dl * acute intoxication.
registry of patients with von willebrand disease treated with voncento®

Conditions: Von Willebrand Disease

Summary: description of the long-term evolution of patients with von willebrand disease and treated with voncento® and of the hemostatic efficacy in the prevention and the treatment of non-surgical bleeding episodes and prevention of surgical bleeding during 2 years after patient inclusion.

inherited von willebrand disease (vwd) is considered the most common bleeding disorder. its prevalence is approximately 1% in the general population but symptomatic patients are rarer (0.01%). it is caused by a partial or total quantitative deficiency (type 1 and type 3) or by a qualitative defect (type 2) of von willebrand factor (vwf), a large multimeric protein that is required for platelet adhesion and serves as factor viii (fviii) carrier. type 2 vwd is further divided in four subgroups (2a, 2b, 2m, and 2n) that are distinguished according to the nature of the vwf defect. most patients with type 1 vwd can be treated with the synthetic vasopressin analogue desmopressin (ddavp; 2-desamino-8-d-arginine vasopressin), whereas patients with type 3 vwd and most patients with type 2 vwd require concentrates containing vwf. plasma-derived fviii concentrates, which were initially developed for the treatment of haemophilia, contain large amounts of vwf and are used in patients for whom ddavp treatment is deemed ineffective or contraindicated. voncento® (csl behring) is a plasma-derived fviii/vwf concentrate registered in france since 2015 for the treatment and prevention of bleeding events in patients with inherited vwd. opale is an observational study describing the use of human coagulation fviii/vwf concentrate (voncento®) to treat and prevent bleeding episodes in a french cohort of patients with inherited von willebrand disease in the real life settings. the aim of the opale study is to describe the efficacy and the safety of voncento® in the prophylaxis and treatment of haemorrhage or surgical bleeding.

Eligibility criteria:
inclusion criteria: * patients suffering from constitutional von willebrand disease for whom desmopressin treatment is deemed ineffective or contraindicated * patients suffering from von willebrand disease and being treated or having been treated with voncento® for the treatment of surgical and non-surgical bleeding episodes, the prophylaxis of surgical and non-surgical bleedings * patients with no history or suspicion of inhibitors (judged on previous efficacy) exclusion criteria: * refusal of the patient or the patient's legal representative to take part in the study; * existence of a contraindication to the use of voncento® treatment

Keywords: vwd von willebrand factor vwf
minimally invasive treatments of the thyroid

Conditions: Papillary Thyroid Microcarcinoma

Summary: this is a prospective cohort study to test minimally invasive treatments of the thyroid (mitt) as potential alternative to surgery in patients with papillary thyroid microcarcinoma (ptmc)

image-guided thermal ablations have been successfully applied in the treatment of several type of tumors, and have been recently proposed as a potential alternative to surgery also in patients with thyroid diseases, and named "minimally invasive treatments of the thyroid (mitt)". these minimally invasive treatments, compared to surgical treatment have similar efficacy, fewer complications, better quality of life, and better cosmetic outcomes. these procedures allow precise delivery of the heat locally to the lesion, sparing the surrounding thyroid tissue, and thus minimizing the invasiveness of the treatment and the impact on thyroid function. this study aim to establish a prospective registry of the cases of patients treated with mitt for a papillary thyroid microcarcinoma (ptmc), in order to validate the safety of the procedure and to set the basis for collecting long term results in a large cohort of patients.

Eligibility criteria:
inclusion criteria: * patients \> 18years * patients with diagnosis of papillary thyroid microcarcinoma, citologically proven, suitable for mitt. * written informed consent must be signed and dated by the patient and the investigator prior to inclusion. * patients must be accessible for follow-up exclusion criteria: * tumors \> 1 cm, other citological type, refusal of mitt, unsuitable for mitt, unmanageable coagulative disorders * patients with psychiatric, addictive, or any disorder, which compromises ability to give informed consent for participation in this study
interferential current and therapeutic exercise program in chronic neck pain

Conditions: Neck Pain

Summary: objectives: to analyze the number of sessions needed to achieve a positive impact after combining interferential current therapy and therapeutic exercise, compared with therapeutic exercise alone, on self-reported pain, disability and range of motion in subjects with chronic neck pain. design: a randomized, single-blind, controlled trial. subjects: patients between 18 and 65 years old, with idiopathic chronic neck pain. methods: the experimental group who will perform a combined treatment using interferential current therapy and therapeutic exercise for two weeks. the control group will receive the same program of therapeutic exercise during the same period of time.


Eligibility criteria:
inclusion criteria: * nonspecific mechanical neck pain (chronic neck pain diagnosed by a physician) * age between 18 and 65 years old * both males and females * non apprehension to electrotherapy (determined by the personal psychological apprehension scale- eapp) * self-reported pain higher than 2 in the 11-point numeric pain rating scale exclusion criteria: * metallic implants in the vertebral column * apprehension to electrotherapy (a score \>45 points in eapp) * cervicogenic headache * cervicogenic dizziness * neck pain associated with neurological deficits * unexplained fever * cervical surgery associated to persistent pain * specific diagnostics (cervical myelopathy, cervical stenosis, osteomyopathy) * other diagnostics such as visceral pain referred to the neck or non-cervical cause. * involvement in litigation * manual treatment for the neck-shoulder area in the last month before data collection

Keywords: chronic neck pain interferential current electrotherapy therapeutic exercise physical therapy
effects of winter swimming on blood indicators and oxidative stress in males

Conditions: Cold Exposure

Summary: exposure of the human body to cold water triggers numerous beneficial physiological changes. the study aimed to assess the impact of regular winter swimming on blood morphological, rheological, and biochemical indicators and activity of antioxidant enzymes in males. the study includes winter swimmers and a control group. blood samples were taken twice - before the start (november) of the winter swimming season and after its end (march). the average duration of ice water baths was 3-5 minutes, with a minimum frequency of once a week. the water temperature during the swimming did not exceed 10°c, approaching 0°c during the winter period.


Eligibility criteria:
inclusion criteria: * good health, practitioners of winter swimming * control group: never did winter swimming and had a sedentary lifestyle. exclusion criteria: * medical contraindications to winter bathing

Keywords: blood rheology cold blood morphology biochemistry exercise