Kornimate/medical-research-clean huggingface dataset:
effect of patient education videos on perioperative anxiety in patients undergoing endoscopic sinus surgery

Conditions: Chronic Rhinosinusitis (Diagnosis)

Summary: chronic rhinosinusitis treatment consists of medical management and surgical intervention. improving patient education can positively impact perioperative patient experiential outcomes such as anxiety, pain and satisfaction. however, online education materials are often too complex, inaccurate or misleading. the objective of this study was to determine if patient education videos at an appropriate reading level would improve perioperative anxiety in patients undergoing endoscopic sinus surgery.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * english speaking * diagnosed with crs according to canadian guidelines * computer or mobile phone access were included exclusion criteria: * immunocompromised * had sinonasal tumours * history of anxiety, depression, bipolar, or any other mental illnesses
brief interventions for coping with distress

Conditions: Distress, Emotional; Emotional Dysfunction; Anxiety; Depression

Summary: this study is being done to compare the effectiveness of three different skills trainings to cope with distress. these three trainings are: 1) an attention skills training, 2) an attention and reflective thought skills training, and 3) a health and wellness education training.

adults living in new york city between the ages of 18-65 and experiencing elevated levels of worry, rumination, and/or self-criticism may be eligible to participate. after being informed about the study and potential risks, participants giving written informed consent will complete an online screening visit to determine full study eligibility. eligible participant will then be randomized to complete 6-weeks of one of three self-directed, online skills training about coping with distress. the present study is evaluating whether these skills trainings demonstrate efficacy in: 1) improving outcomes specific to an emotion regulation model of emotional distress (e.g., attentional control, decentering, reappraisal); 2) reducing symptoms of psychological distress (e.g., anxiety, depression, worry, rumination). primary assessment points will take place before and after the skills training, and will include self-report measures, brief surveys during daily life, as well as computer tasks and measures of brain and body activity (e.g., eeg).

Eligibility criteria:
inclusion criteria: * between the ages of 18 and 65 * fluent in english (and therefore able to provide consent) * currently living in new york city * access to a smartphone and the internet * high self-reported worry, rumination, and/or self-criticism * meet diagnostic and statistical manual of mental disorders - fifth edition (dsm-5) criteria for at least one, current psychological disorder exclusion criteria: * active suicidal ideation or intent * substance dependence disorder, schizophrenia, bipolar-i disorder, or a primary dsm-5 diagnosis of borderline or narcissistic personality disorder * individuals currently receiving therapy or psychosocial treatment who do not plan to continue with the same treatment throughout the study period * individuals taking psychotropic mediation that has not been stabilized for a period of at least 3 months * current students at teachers college, columbia university * individuals with cardiac conditions, diagnosed hyperhidrosis, and traumatic brain injuries or other neurological conditions (e.g., dementia, parkinson's, epilepsy)

Keywords: emotion regulation distress disorders anxiety depression worry rumination self-criticism skills training
phase ii of high-dose therapy in elderly patients with relapsed aggressive nhl or resistant to first line therapy

Conditions: Non Hodgkin Lymphoma

Summary: a phase ii prospective, non-randomized study. the study aim is to evaluate the feasibility and activity of high-dose therapy with stem cell in elderly patients with aggressive lymphoma relapsed fit or resistant to first line therapy.

the study aim is to evaluate the toxicity and activity of a therapeutic approach to high doses with support of peripheral blood stem cells (pbsc) in patients aged ≥ 65 and ≤75 years, chemosensitive relapsed or refractory to therapy first line in terms of event free survival (efs) and treatment related mortality (trm)

Eligibility criteria:
inclusion criteria: * diagnosis of nhl * relapse and refractory pts * age ≥ 65 and ≤75 * ecog performance status \<2 * fit patients (instrumental activity of daily living (iadl)=8, activity of daily living (adl)=6, cumulative illness rating scale (cirs) =0 score=3-4, \<5 score=2 ) * evaluable disease * no rt since 3 week * absolute neutrophil count \>= 1500/mm3 and platelets \>= 100.000/106l * creatinin \ 40 ml/min/24 h * bilirubins \< =2 mg/dl * forced expiratory volume \>50% - arterial pressure o2 \>70 mmhg * no other neoplastic disease * life expectancy\> 3 months * signed informed consent exclusion criteria: * hbv+ - hcv+ - hiv+ * nsc involvement - medullar infiltration \> 20% * other chemotherapy or radiotherapy * cardiac disease * alteration of liver and kidney function * infections * demented patient * no compliance and depressed pts * frail and unfit pts
an observational study of treatment patterns and safety outcomes for metastatic or locally recurrent breast cancer (virgo)

Conditions: Breast Cancer

Summary: this is a multicenter, prospective observational cohort study (ocs) designed to follow patients with locally recurrent or metastatic breast cancer in the united states. two cohorts will be included: * patients with human epidermal growth factor receptor 2-negative (her2-negative) disease receiving their first cytotoxic chemotherapy and/or targeted therapy (approximately 825 patients) * patients with hormone receptor-positive (hr-positive) disease receiving their first hormonal therapy for advanced disease (approximately 425 patients) patients who have received any chemotherapy for advanced disease more than 8 weeks prior to enrollment to this ocs will not be eligible. a total of approximately 1,250 patients will be enrolled. approximately 150 study sites will be activated in order to achieve complete enrollment by december 2010.


Eligibility criteria:
inclusion criteria: * signed informed consent form * locally recurrent or metastatic breast cancer * receipt of first systemic cytotoxic chemotherapy and/or targeted therapy among those with her2-negative disease or first hormone therapy among those with hr-positive disease for the treatment of locally recurrent or metastatic disease, within 8 weeks prior to enrollment exclusion criteria * any medical condition, including mental illness or substance abuse, deemed by the investigator to be likely to interfere with a patient's ability to provide informed consent or comply with the treatment * any prior chemotherapy started more than 8 weeks prior to enrollment for the treatment of locally recurrent or for metastatic breast cancer * concurrent participation only in a blinded clinical trial

Keywords: metastatic breast cancer locally recurrent breast cancer avastin
kaiser permanente evaluating nutritional interventions in food-insecure high-risk adults study

Conditions: Diabetes Mellitus, Type 2

Summary: the goal of this randomized controlled trial is to compare the effect of receiving 6 months of monetary support for healthy food through a food delivery platform on change in glycosylated hemoglobin (hba1c) levels among adults with type 2 diabetes mellitus with glycemic control that is above target level. the main study aims are to: 1. to evaluate whether providing monthly financial support for home-delivered healthy food vs. only free food delivery through the instacart platform reduces glycosylated hemoglobin levels within 6 months among medi-cal-insured kaiser permanente adult members with diabetes mellitus and suboptimal glycemic control. 2. to evaluate whether providing monthly financial support for home-delivered healthy food vs. only free food delivery through the instacart platform reduces medical resource utilization within 6 months among medi-cal-insured kaiser permanente adult members with diabetes mellitus and suboptimal glycemic control.

eligible kaiser permanente adult members will be randomized to one of two groups: 1. intervention arm, in which subjects will receive 6 months of monetary support (with up to 4 free home deliveries and no service fees) through the instacart platform to select and receive healthy foods (e.g., vegetables and fruit). 2. control arm, in which subjects will receive 6 months of free home deliveries and no service fees for up to 4 deliveries each month through the instacart platform. glycosylated hemoglobin level will be assessed at baseline and at 6 months after enrollment. medical resource utilization will be evaluated at 3 months, 6 months, and 12 months after enrollment. patient-reported outcomes (i.e., diabetes quality of life, nutrition security, dietary habits, social needs, and food security) will also be assessed at baseline, 6 months, and 12 months after enrollment.

Eligibility criteria:
inclusion criteria: * adults aged ≥18 years old at enrollment * active membership in kaiser permanente with medi-cal insurance and no additional private or commercial insurance * diagnosis of type ii diabetes mellitus (not including type i diabetes mellitus or gestational diabetes mellitus) * at least 2 outpatient glycosylated hemoglobin measures ≥7.5% in the prior 18 months * current access to the internet via computer or mobile device * no interpreter needed exclusion criteria: * advanced or end-stage kidney disease (estimated glomerular filtration rate ≤15 ml/min/1.73m\^2 or receiving outpatient dialysis or having a prior kidney transplant) * known pregnancy at time of identification
automated diagnostic test for diabetic retinopathy in brazilian mass screening

Conditions: Diabetic Retinopathy

Summary: in brazil 10% of the adult population has diabetes. of these, 39.0% are undiagnosed, at risk for developing complications such as diabetic retinopathy (dr). due to the increasing prevalence of diabetes and high percentage of patients with uncontrolled disease, cost-effective tools are needed with focused attention on diabetes prevention and management in the current health system. the automatic retinopathy detection can enlarge the screening, reducing the workload and costs compared to manual image graders.

in the south and central america region, an estimated 9.4% of the adult population (20-79 years) has diabetes in 2015, and brazil is the first country in number of people with diabetes. of these, 39.0% are undiagnosed, at risk for developing complications such as diabetic retinopathy (dr)(1). the rising number of people with diabetes in the world has become a real challenge for the public health system to provide care for patients with dr and for people with diabetes at risk for this complication(2). a large proportion of patients with diabetes was inadequately controlled in brazil, which may contribute to increased rates of diabetic complications (3). the detection of any degree of dr may result in improved medical monitoring and optimization of risk factors, delaying the progression of the disease(4). in brazil, the great demand in the public service causes delay in early diagnosis, worsening health status of patients with diabetic retinopathy and increasing the cost of their treatment. due to the increasing prevalence of diabetes and high percentage of patients with uncontrolled disease, cost-effective tools are needed with focused attention on diabetes prevention and management in the current health system. several studies have shown that systematic screening for dr is an effective way of prevention (5). furthermore, the automatic retinopathy detection can enlarge the screening, reducing the workload and costs compared to manual image graders(6). there are no reports on automated dr detection in brazilian population, especially in screening campaigns with large-scale diagnosis.

Eligibility criteria:
inclusion criteria: * adults ≥ 18 years with type 1 or 2 diabetes mellitus exclusion criteria: * previous cataract, trabeculectomy or vitrectomy * aphakia * external ocular infections * glaucoma (iop of \> 21 mmhg or regular use of more than 2 iop lowering drugs) * pregnancy or breastfeeding.
adult stem cell response to burn injury

Conditions: Wound Healing; Burn

Summary: this study is designed to determine the response of adult stems cells, also referred to as mesenchymal stem cells (mscs), to tissue injury resulting from thermal burns. the study will consist of a one time collection of a patient's blood, about one teaspoon, on the third day following the initial burn. mscs in the blood will then be quantitated and identified using according to unique proteins found on their cell surface using flow cytometry. the results of flow cytometry analysis will then be compared to the patients characteristics (age, sex, race, etc.), their past medical history (hx of diabetes, hypertension, heart disease, etc.) and to the patient outcome (length of hospital stay, mortality, etc.).

traumatic and non-traumatic disease processes result in varying tissue injury that can culminate in organ failure and death. current literature has demonstrated that adult stem cells (ascs) are mobilized into peripheral circulation as a heterogeneous population of cells following tissue injury. the significance of this heterogeneity has not yet been defined. other studies have shown ascs augment tissue repair under appropriate conditions. this proposal will begin to elucidate the mechanism of asc activation, mobilization and localization to sites of injury. this study will use flow cytometry to identify subsets of ascs mobilized in response to tissue injury and compare this response to the patient's demographics, comorbidities, in hospital morbidities, and mortality. patients with thermal burns will be used as a model of tissue injury given the quantity of tissue injured and the robust signal generated from this injury. ascs are currently being investigated as adjuncts to tissue repair involving a host of tissues, including cardiac, neural, and renal. the identification of a specific subset of ascs selectively mobilized in response to tissue injury would alter all studies involving ascs in tissue repair and necessitate the identification and targeting of subsets selectively mobilized in response to injury to each particular tissue.

Eligibility criteria:
inclusion criteria: * any consentable patient presenting to the ohio state university emergency department or directly admitted to the ohio state university burn unit within three days of a thermal burn exclusion criteria: * prisoners * pregnant patients and nonconsentable patients.

Keywords: mesenchymal stem cells, burn
selinexor in advanced liposarcoma

Conditions: Dedifferentiated Liposarcoma

Summary: this is a randomized, multicenter, double-blind, placebo-controlled, phase 2-3 study of patients diagnosed with advanced unresectable dedifferentiated liposarcoma. approximately 342 total patients will be randomized to study treatment (selinexor or placebo).

in the phase 2 portion of the study, 57 patients were randomized to selinexor (60 mg) or placebo at a 1:1 allocation ratio. in the phase 3 portion of the study, approximately 285 patients will be randomized to selinexor (60 mg) or placebo with a 2:1 allocation ratio. patients who progress during the blinded portion of the study will be unblinded and if receiving: * placebo, may cross over to open-label selinexor (60mg twice-weekly) * selinexor, will be withdrawn from further treatment and followed for survival study treatment will be given twice-weekly on day 1 and day 3 during weeks 1-6 of each six-week (42 day) cycle until disease progression or intolerability. treatment will continue until one or more of the following occurs: * disease progression, as defined by recist v1.1 response criteria * clinical progression, as determined by the treating physician * unacceptable adverse events (aes) or failure to tolerate study treatment * patient withdrawal * patient discontinuation due to non-compliance

Eligibility criteria:
inclusion criteria: 1. patients ≥12 years of age 2. body surface area (bsa) ≥ 1.2 m2 3. histologic evidence of ddls at any time prior to randomization and current evidence of ddls requiring treatment 4. must have measurable disease per recist v1.1 response criteria 5. radiologic evidence of disease progression within 6 months prior to randomization. if the patient received other intervening therapy after documented disease progression, further disease progression must be documented after the completion of the intervening therapy 6. must have had at least 2 prior lines of systemic therapy for liposarcoma (not to exceed 5 prior lines) 7. if patient received any previous systemic therapy, the last dose must have been ≥ 21 days prior to randomization (or ≥ 5 half-lives of that drug, whichever is shorter) with all clinically significant therapy-related toxicities having resolved to ≤ grade 1 exclusion criteria: 1. patients with pure well-differentiated liposarcoma (wdls), myxoid/round cell or pleomorphic tumor histologic subtypes 2. known active hepatitis b (hepb), hepatitis c (hepc) or human immunodeficiency virus (hiv) infection 3. known central nervous system metastases

Keywords: advanced unresectable dedifferentiated liposarcoma selinexor kcp-330 karyopharm phase 2 / 3 dedifferentiated liposarcoma liposarcoma
vale+tú salud: corner-based randomized trial to test a latino day laborer program adapted to prevent covid-19

Conditions: COVID-19

Summary: the purpose of this study is to assess the extent to which ldl report increased adherence with covid 19 mitigation practices 1 month post intervention.


Eligibility criteria:
inclusion criteria: * self-identify as hispanic or latino * be present at the corner for the purposes of looking for work exclusion criteria: * have not been previously hired to work at a corner * symptoms of covid-19 in the previous 48 hours

Keywords: latino day laborers
newborn screening for congenital heart disease

Conditions: Congenital Heart Disease

Summary: the purpose of this study is to test the accuracy of 7 indicators in screening congenital heart defects (chd) in all newborns (symptomatic or asymptomatic) to determine whether these indicators could be applied in the nationwide newborn chd screening. the investigator's hypothesis is that 7 indicators are effective in neonate chd screening with the acceptable accuracy.

congenital heart defects (chd) are among the most common major congenital anomalies, and they occur worldwide with an incidence of about 8-12/1,000 live births , most of these defects are mild or moderate. they either do not need treatment or treatment is needed only after infancy. other defects are severe and require early treatment in infancy, which are the primary objectives of screening, because they are at risk of adverse or irreversible outcomes as a consequence of congenital heart defects. however, about half the neonates in the nursery have no distinctive clinical signs (symptoms, abnormal murmurs or cyanosis).so it's necessary to develop a screening strategy for neonatologist and pediatrician, especially physicians in community. screening strategy in our study consists of 7 indicators: family history of chd, tachypnea, heart murmurs(≥ 2 grade), cyanosis, other non-cardiac malformations,special face feature（relating to chromosomal or non-chromosomal syndromes）, subnormal pulse oximetry reading (oxygen saturation of less than 95% in either limb or more than 3% difference）。the newborn babies with any of these 7 indicators positive will be considered positive-screened and echocardiography will performed. the whole study (screening for chds with 7 indicators and performing the echocardiography for diagnosis) will be conducted by one single investigator (quming zhao from children's hospital of fudan university). the new generation pulse oximetry has been proved to have low intraobserver and interobserver variability, but the interobserver variability in clinical evaluation (especially murmurs and cyanosis) remain unknown, the investigator will also assess the interobserver variability by comparing quming zhao and other two pediatricians (from the participating hospital)(blind to each other).

Eligibility criteria:
inclusion criteria: * all consecutive live newborn infants * between 6-72hours of age exclusion criteria: * declining the screening; * early discharge before the screening; * missing

Keywords: congenital heart disease newborn pulse oximetry screening
remote monitoring of diabetes in young children with type 1 diabetes

Conditions: Type 1 Diabetes Mellitus

Summary: the primary objective of this project is to examine the impact of a continuous glucose monitoring (cgm) intervention on health and psychological outcomes in young children with type 1 diabetes (t1d).


Eligibility criteria:
to be eligible for the study, a child must meet the following criteria: 1. diagnosis of type 1 diabetes according to american diabetes association diagnostic criteria 2. time since diagnosis of at least six months 3. age between 2 and 6 years at enrollment 4. parental consent to participate in the study 5. no severe medical conditions, which in the opinion of the investigators are likely to hinder participation in this clinical trial. 6. if current use of cgm, a1c has to be above 7.5%; value obtained within 3 months of enrollment 7. own and use an iphone, or be willing/able to carry a study-supplied wi-fi enabled ipod to be eligible for the study, a parent must meet the following criteria: 1. parent or legal guardian of a child with type 1 diabetes meeting the "child" criteria outlined above 2. age of 18.0 years or older 3. parent comprehends written english 4. parent understands the study protocol and signs the informed consent document 5. parent has access to a personal computer to upload diabetes devices and send to research team the presence of any of the following is an exclusion for the study: 1. child has a medical disorder that in the judgment of the investigator will interfere with completion of any aspect of the protocol (e.g., pregnancy, kidney disease, adrenal insufficiency, skin condition that may hinder sensor application). 2. child has a neurologic disorder that in the judgment of the investigator will affect completion of the protocol 3. current use of oral glucocorticoids or other medications, which in the judgment of the investigator would be a contraindication to participation in the study 4. child is unable to completely avoid acetaminophen for duration of study
relative sarcopenia and cardiometabolic risk in young adults with obesity

Conditions: Overweight and Obesity; Insulin Resistance

Summary: the goal of this research study is to learn more about the hormones that muscles make during exercise, and if those hormones are associated with type 2 diabetes risk in adults who are overweight or obese. participants will undergo exercise testing on an upright bicycle, with blood samples taken for muscle hormones before and after exercise. the hypothesis is that adults with overweight/obesity and insulin resistance will have an impaired muscle hormone profile in response to exercise compared to adults with overweight/obesity who are not insulin resistant.


Eligibility criteria:
inclusion criteria: * previously enrolled in protocol 2004p000013 or protocol 2012p002276, which had overweight or obesity as inclusion criteria * ability to walk up 3 flights of stairs and 3 city blocks (to ensure ability to complete exercise testing) exclusion criteria: * unstable heart or lung disease * exercise \>150 minutes/week * participation in college sports