Kornimate/medical-research-clean huggingface dataset:
transplantation of deceased donors with covid-19 into covid-19 negative recipients utilizing casirivimab and imdevimab antibody cocktail

Conditions: COVID-19; Organ Transplant

Summary: this study will look to increase the donor pool for the solid organ transplant population by transplanting patients who died with covid-19 but not from covid-19 utilizing casirivimab and imdevimab antibody cocktail to prevent the transmission of the virus.

this is single-center, proof of concept study that is expected to last up to three months. the target enrollment for this study is 14 subjects ≥18 years of age with a need of a kidney, liver or heart. this study will investigate the effects of the investigational product during a four-week intervention phase followed by a 12-month observation phase. study population will be derived from patients in northwell health transplant center.

Eligibility criteria:
inclusion criteria: 1. subject provides written informed consent prior to initiation of any study procedures. 2. understands and agrees to comply with planned study procedures. 3. adult ≥18 years of age at time of enrollment, pediatric ages will be excluded. 4. subject consents to receiving a covid-19 positive organ (kidney, liver, or heart) a. deceased immunocompetent donor with positive sars-cov-2 rt-pcr testing from the respiratory tract (upper or lower): i. within 21 days since the date of covid-19 diagnosis or ii. within 90 days since the date of covid-19 diagnosis 5. subject is confirmed covid-19 negative confirmed by pcr at time of transplant with no signs and symptoms consistent with covid-19 6. all candidates must be fully vaccinated 2 weeks prior to enrollment a. when applicable candidates can receive a booster vaccine as defined by the fda/cdc exclusion criteria: 1. any exposure to investigational medications targeting covid-19 2. previous use of casirivimab with imdevimab antibody cocktail (regen-cov) 3. previous treatment of covid-19 with a monoclonal antibody 4. active covid-19 infection 5. allergy to casirivimab with imdevimab 6. pregnant patients 7. prior transplant 8. hepatitis c virus/nct positive deceased donors

Keywords: regeneron covid-19 antibodies
study cyclosporine (csa) versus tacrolimus (tacro) after campath induction in kidney transplantation

Conditions: Acute Graft Rejection; Chronic Allograft Nephropathy; Polyomavirus-related Transplant Nephropathy

Summary: after alemtuzumab induction, followed with kidney transplantation, patients will be randomly assigned to receive either tacrolimus or cyclosporine microemulsion in combination with mycophenolates. patients will be followed including protocol biopsy at 1, 12, 36, 60 month posttransplant, regular nuclein acid testing (nat) for cytomegalovirus (cmv), epstein-barr virus (ebv) and bk virus (bkv) in urine and blood. the investigation is undertaken to clarify the reason for equal survival rates for patients on cyclosporine and tacrolimus despite the lower rejection rate on tacrolimus.

special attention will be paid to the epidemiology of virus infections behind one year post transplant. very limited data are available on this issue and there is suspicion that tacrolimus patients suffer more hard with viruses like cmv, ebv, bkv. these viruses can induce graft nephropathy and threat to the life of the recipient.

Eligibility criteria:
inclusion criteria: * first kidney allograft recipients * alemtuzumab induction exclusion criteria: * cni intolerance

Keywords: rejection survival alemtuzumab cyclosporine tacrolimus
investigation of the effects of h-prf on the period after impacted third molar tooth extraction

Conditions: Impacted Third Molar Tooth

Summary: after wisdom teeth are extracted, the patient may have some complaints in the post-operative period. pain, swelling and edema are some of them. these inflammatory complications are important for patients and surgeons to reduce the risk of complications and ensure postoperative recovery and develop customized strategy. many studies have been conducted in the literature to minimize these situations encountered after tooth extraction.

many studies have been conducted in the literature to minimize these situations encountered after tooth extraction. various regenerative methods are being developed to reduce these complaints of patients. regenerative treatments include non-steroidal anti-inflammatory drugs (nsaids), laser therapy, steroids, ultrasound, and prf applications. prf(platelet-rich fibrin) application placed in the extraction socket is one of the regenerative methods used to reduce these complaints. prf has a fibrin structure obtained from natural blood tissue, containing abundant platelets and leukocytes. this fibrin matrix contains various growth factors and cytokines, including growth factor-beta1 (tgf-β1), platelet-derived growth factor (pdgf), vascular endothelial growth factor (vegf), interleukin (il), as well as platelets and leukocytes. these factors act directly on promoting the proliferation and differentiation of osteoblasts, endothelial cells, chondrocytes, and various fibroblast sources. it is known that prf has a beneficial effect in relieving pain and swelling and reducing the incidence of alveolar osteitis after extraction of an impacted lower third molar. therefore, it is placed in extraction sockets to try to reduce post-operative complications. prf applications are also developing in their own right, and one of them is the h-prf (horizontal prf) application. recently, horizontal centrifugation of prf has been shown to provide better cell layer separation and minimize cell accumulation that prevents uniform cell layer formation on the distal surfaces of centrifuge tubes.

Eligibility criteria:
inclusion criteria: * volunteer asa i individuals between the ages of 18-40 exclusion criteria: * those who are pregnant or lactating * those receiving anticoagulant or antiplatelet drug therapy * those who received radiotherapy to the head and face area * those who are allergic to local anesthetics and prescribed medications

Keywords: impacted third molar tooth, prf
comparison of different methods of pain control after cesarean section for patients on buprenorphine or methadone

Conditions: Caesarean Delivery

Summary: more and more women are on buprenorphine or methadone during pregnancy for a history of opioid addiction. currently, pain control after cesarean section for women already on these medications, if they need operative delivery, is a challenge due to the pharmacology of those drugs. they have higher pain scores and 45-47% higher opiates requirement. to improve pain control, some unique regional anesthesia techniques have been employed, besides opioid and non-opioid medication management through the oral, intravenous, and/or neuraxial (spinal or epidural) route. one is a tap block ( transversus abdominis plane block), a regional anesthesia procedure in which long acting local anesthetic, such as ropivacaine, is injected on both sides of the patient's abdomen to numb the nerves supplying the abdominal wall, or the surgical site. another is a patient - controlled epidural, a small flexible catheter that is inserted in the back into the epidural space near the spine, which bathes the spinal nerve roots with long acting local anesthetic, such as bupivacaine, and with an opioid, such as fentanyl, to numb the nerves going to the surgical site. through an epidural pump, the patient receives a continuous infusion of local anesthetic and can delivery more medication as needed through a bolus feature. there have case reports, or case by case accounts, of these techniques, and it is suspected these techniques result in better pain control with minimal side effects. no clinical, human or animal, has evaluated these techniques in a controlled and through manner, either comparing the two techniques to each other or comparing them to the common care of opioid and non-opioid medication management through the oral, intravenous, and/or neuraxial route, including neuraxial hydromorphone or morphine.


Eligibility criteria:
inclusion criteria: * anesthesiology society of anesthesiologist's status of ii or iii * maintenance methadone or buprenorphine during pregnancy * regional anesthesia staff to perform a tap block * elective, non-urgent cesarean delivery via a pfannenstiel incision under regional anesthesia exclusion criteria: * emergency cesarean section * laboring patients who are now having to delivery operatively * patients with a bmi over 50 * patients with allergies to any of the study medications * patients under 18 years old * patients with multiple gestations * patients undergoing general anesthesia * patients who had contraindications for either an epidural or a tap block as in coagulopathies, chronic back pain, skin conditions, or existing neuropathies * patients who cannot understand the use of a patient controlled epidural analgesia

Keywords: buprenorphine suboxone subutex buprenex caesarean delivery
multiparametric mri in men with prostate cancer undergoing active surveillance

Conditions: Prostatic Neoplasms

Summary: to investigate whether multiparametric mri (mp-mri) in patients with low-risk prostate cancer can improve the selection of patients suitable for active surveillance and have a relevance in the ongoing monitoring.

men with localized prostate cancer (pca) with small tumor burden may be followed on active surveillance (as) rather than active treatment. as is an attempt to avoid over-treatment of pca, which is estimated to be insignificant at the time of diagnosis, and therefore unlikely to affect patient morbidity and mortality. as include close monitoring with psa measurement (blood test), digital rectal exploration (dre) and trans-rectal ultrasound-guided prostate biopsy (trus-bx) at regular intervals, so that active treatment can be initiated if the cancer becomes more aggressive. it is crucial that patients undergoing as are staged correctly, to avoid underestimating more aggressive disease and patients mistakenly are enrolled into as instead of active treatment. previously, a phd study conducted at herlev hospital revealed that multiparametric mri (mp-mri) of the prostate can improve the detection and staging of pca and may add additional information about tumor aggressiveness compared to the traditional methods dre and trus-bx. mp-mri at the inclusion of as may detect missed significant tumors and potential areas of higher aggressiveness than detected by the traditional biopsies. additional targeted biopsies from these suspicious areas can then be performed with a re-evaluation of the treatment plan, if more advanced disease is identified. conversely, mp-mri has a high negative predicted value for significant disease and can be used to rule out significant pca, reassuring patients and physicians to go on with as. mp-mri has been used at the urology department, herlev hospital, since 2013 in the diagnosis of pca and in the evaluation of patients undergoing as. the main objective of this study is to retrospectively investigate, whether mp-mri can improve the selection of patients suitable for active surveillance and have a relevance in the ongoing monitoring.

Eligibility criteria:
inclusion criteria: * patients with low risk localized prostate cancer enrolled in active surveillance exclusion criteria: * metastatic prostate cancer * no mp-mri data present * prostate cancer treatment * known allergic reaction to gadolinium-based mri contrast agent * prostate biopsy during the last 21 days * impaired renal function with gfr \< 30 ml / min * pacemaker * magnetic metal residues in the body * claustrophobia * psychiatric disorders * age under 18 years

Keywords: prostate biopsy prostate cancer magnetic resonance imaging neoplasm staging
cardiac magnetic resonance for risk stratification in dilated cardiomyopathy

Conditions: Dilated Cardiomyopathy; Single-center Study

Summary: dilated cardiomyopathy (dcm) is an increasingly recognized cause of morbidity and mortality with heterogenous etiologies (eg, genetic, environment) and clinical manifestations, characterized by left ventricular (lv) systolic dysfunction and lv or biventricular dilation. previous publications reported the three-year treated mortality rates remain high at 12%-20% and a reported 5-year mortality rate up to 50%, with death resulting from ventricular arrhythmia leading to sudden cardiac death (scd) or advanced heart failure (hf). with large fields of view and high spatial resolution, cardiac magnetic resonance (cmr) is the reference standard for assessing cardiac mass, volume, and function. cmr also provides non noninvasive characterization of the myocardium benefiting to differential diagnosis and risk stratification.


Eligibility criteria:
inclusion criteria: 1. reduced left ventricular ejection fraction (lvef\<50%) 2. lv end-diastolic volume \>2sd from normal according to normograms corrected by body surface area (bsa) and age. exclusion criteria: 1. any evidence indicating the presence of ischemic heart disease: coronary angiography, perfusion imaging medical documentation that indicated the presence of ischemic heart disease an infarct pattern of late gadolinium enhancement on cardiac magnetic resonance studies and/or acute coronary syndrome or coronary revascularization during follow-up 2. any evidence of hypertrophic cardiomyopathy, or moderate-to-severe valvular disease\[18\], or infiltrative disease (such as amyloidosis, sarcoidosis, fabry disease) 3. incessant arrhythmias 4. inability to lie flat 5. pregnancy 6. contraindication to cardiac magnetic resonance including severe claustrophobia, defibrillators, pacemakers, certain types of intracranial aneurysm clips, intraocular metal, and stage iv/v chronic kidney disease 7. diabetes mellitus with end organ damage 8. inability to provide informed consent.

Keywords: dilated cardiomyopathy cardiovascular magnetic resonance imaging prognosis
serenade parent-child music class program

Conditions: Autism Spectrum Disorder

Summary: this pilot study examines the impact of the serenade parent-child music class program, which emphasizes parent training, peer inclusion, and musical play combined with established behavioral techniques, on the development of child social engagement, positive behavior, and parental well-being.

this pilot study evaluates the impact of the serenade parent-child music class program on families of children with and without autism spectrum disorders (asd). this study examines the impact of this program on social development in children with asd, parental stress and efficacy, and parent-child relationships. a primary goal of this study is to examine multiple levels of analysis including families' experience within and outside of the music class program.

Eligibility criteria:
inclusion criteria: * children diagnosed with asd or children without asd exclusion criteria: * currently enrolled in music therapy or parent-child music classes (for children with asd); significant behavior problems (e.g., aggression toward other children); significant hearing or visual impairments
dietary intervention with phytochemicals and polyunsaturated fatty acids in prostate cancer patients

Conditions: Prostate Cancer

Summary: we will study the effect of dietary intervention in patients with prostate cancer. outcomes include serum psa kinetics, as well as biomarkers of inflammation, antioxidant status, oxidative stress and oxidative damage in blood cells, plasma, urine and prostate tissues

a total of 102 patients with localized prostate cancer will be included in the study. a the time of inclusion, the participants will be randomized to three groups. the intervention groups includes; control group, tomato group and multi-diet group. the intervention period is three week and will be completed before prostatectomy or radiation therapy. biomarkers og inflammation includes: acute phase proteins, cytokines, chemokines and other inflammatory mediators. biomarker of antioxidant status includes vitamin c, vitamin e, glutathione, carotenoids, total antioxidant capacity and total phenolics. oxidative stress markers includes; malondialdehyde, isoprostanes, 8-hydroxy-deoxyguanosine, oxidized vitamin c, total lipidperoxides (d-rom) and protein carbonyls.

Eligibility criteria:
inclusion criteria: * adenoarcinoma (as confirmed by histology) * pn0/nxm0 (tnm/uicc 2002) and at least one negative prognosis factor for hdr-bt or low risk profile with the use of radical prostatectomy. * serum psa\ 6 or t1c- t3a, prostate volume \< 60ml * performance status 0-1 * normal wbc and thromocytes, hb \>11g/dl exclusion criteria: * no previous endocrine treatment * life expectancy \> 5 år * no possible co-morbidity (cvd, copd, diabetes type i, vasculatory syndromes or inflammatory diseases that may affect quality of life and radiation therapy) * urinary retention, incontinens or ipps score \<12

Keywords: prostate cancer psa antioxidant phytochemical tomatoes pufa selenium soy pomegranate grapes
opioid sparing anaesthesia for prevention of postoperative nausea and vomiting in laparoscopic gynecological surgery

Conditions: PONV; Opioid Sparing Anaesthesia

Summary: in spite of multimodal analgesic strategies, which consist of opioids, dexamethasone, non-steroidal anti-inflammatory drugs, and local anesthetics applied into the surgical wound, postoperative pain and postoperative nausea and vomiting (ponv) are still common complaints reported after laparoscopic gynecological surgery. so, it is hypothesized that the infusion consisting of lidocaine, dexmedetomidine and ketamine, as an opioid substitute was a feasible technique for laparoscopic gynecological surgery and would be associated with less incidence of ponv and lower opioid requirements in the early postoperative period. the aim of this study was to evaluate the effect of opioid sparing technique via infusion of dexmedetomidine, ketamine and lidocaine on post-operative nausea and vomiting in laparoscopic gynecological surgery.


Eligibility criteria:
inclusion criteria: * patients scheduled for elective laparoscopic gynaecological surgery, who: * had the american society of anesthesiologists (asa) i or ii physical status, * were 21-60 years of age exclusion criteria: * a body mass index \>35 kg/ m2 * pregnant, breast feeding women * hepatic, renal or cardiac insufficiency * diabetes mellitus * history of chronic pain * alcohol or drug abuse * psychiatric disease * allergy or contraindication to any of the study drugs

Keywords: laparoscopic gynecological surgery dexmedetomidine ketamine lidocaine ponv
dti in children with multiple sclerosis

Conditions: Multiple Sclerosis - Relapsing Remitting; Clinically Isolated Syndrome, CNS Demyelinating

Summary: this is a prospective, non-randomised, non-blinded, single center study of children and adolescents with multiple sclerosis and clinically isolated syndrome to detect differences or early changes in diffusion-weighted imaging (dti) by magnetic resonance imaging (mri).

in children and adolescents with either multiple sclerosis or clinically isolated syndrome an mri with special dti-sequences of the brain is performed at timepoint of first manifestation of disease and every 6 months at 3 tesla mri according to a specific investigation protocol. besides mri-dti several clinical data are recorded every 6 months: 1. expanded disability status scale (edss) 2. disease activity/ relapse rate 3. lesion load (number of t2-lesions) 4. brain atrophy 5. visual and somatosensoric evoked potentials (vep, ssep) 6. neuropsychological examination furthermore a complete neurological examination is done every 6 months and particular medication of each patient is recorded in a specific investigator form (case report form, crf)

Eligibility criteria:
inclusion criteria: * informed consent * diagnosis of multiple sclerosis (ms) according to the mcdonald criteria 2010 and the consensus recommendations of international pediatric ms study group (ipmssg) (krupp et al 2013) * diagnosis of cis according to the consensus recommendation of ipmssg (krupp et al 2013) * all types of medication/therapy exclusion criteria: * pregnancy * claustrophobia * allergic reaction of gadolinium (contrast medium) * implantation of cardiac device * implantation of neurostimulators * implantation of cochlea implants * presence of tattooing (over 20% of body surface) * presence of permanent-make-up * presence of permanent transdermal patches * presence of special catheter systems with temperature probes which cannot be removed * implantation of metalliferous implants or implants which could contain metal traces * implantation of artificial heart valves * implantation of stents or coils * presence of metal fragments in the eyes

Keywords: pediatric multiple sclerosis clinically isolated syndrome in children biomarker magnetic resonance imaging diffusion weighted imaging
acute coronary syndrome in patients with covid-19

Conditions: Myocardial Infarction; Acute Coronary Syndrome; COVID-19; Myocardium; Injury

Summary: the aim of this study was to find a clinical or laboratory parameter, that would help in distinguishing between covid-19 patients with myocardial infarction (mi), who have an infarct-related artery (ira) and therefore, require immediate revascularization, and those, who have no ira.

the coronavirus pandemic has hit the world with its vast contagiousness, high morbidity, and mortality apart from the direct damage to the lung tissue, the corona virus infection is associated with multiple organ damage, including the heart. emerging evidence reveals a direct correlation between covid-19 and cardiovascular complications, such as heart failure, myocarditis, arrhythmias, conduction abnormalities and acute coronary syndromes. the sars-cov-2 infection can frequently induce coagulation abnormalities that are associated with cardiopulmonary deterioration and death as a possible complication in all patients, despite presence or absence of concomitant risk factors and diseases. in addition, many patients with severe covid-19 undergo thromboembolic events, which seem to be related to this particular coagulopathy. one of the most unpleasant and life-threatening types of thromboembolism is the one involving the coronary circulation, thus causing a heart attack. many additional problems arise due to this condition e.g., access to a cath lab, exposure of additional medical personnel, more complications and increased mortality for the patients. invasive angiography for covid-19 patients is logistically challenging and, in some cases, there is no intervention target, since microcirculatory disease and thrombosis is common in this group. therefore, the investigators studied in detail the case series of 10 patients referred for primary percutaneous coronary intervention (ppci) for mi in our catheterization laboratory during the course of covid-19 infection. and the investigators set themselves the purpose to evaluate if there are some factors or parameters that could predict the presence of an interventional target - infarct related artery (ira), prior to catheterization, and to determine their sensitivity and specificity.

Eligibility criteria:
inclusion criteria: * acute coronary syndrome (acs) * covid-19 infection exclusion criteria: * no combination of acs and covid-19 infection

Keywords: covid-19 coronavirus acute coronary syndrome troponin