Kornimate/medical-research-clean huggingface dataset:
the influence of glucose flux on fat synthesis in a whole body calorimeter

Conditions: Type 2 Diabetes, Obesity, Prediabetes

Summary: the study is carried out to find out the inclusion of high and low glycaemic index foods to daily meals and how they impact 24 hour blood glucose fluctuations and energy regulation.

the gi is a method of classifying foods based on the food's ability to raise the blood glucose level. low gi foods are recommended as they have a lower impact on blood glucose concentrations. the research sets out to determine the effect of gi on 24 hour blood glucose profiles and energy regulation in asians. healthy, normal-weight, chinese males will be recruited. there will be two sessions (consisting of four days for each session) where they will consume either a high or low gi breakfast, lunch, snack (in the whole body calorimeter), and a high or low glycaemic index dinner at home. they will take part in two test sessions (each spanning over 3 days) with at least five days in between the two sessions. their glycaemic response will be measured using a continuous glucose monitoring system (cgms) throughout the period, while substrate oxidation will be measured over 10 hours in the calorimeter (from breakfast, lunch and snack). this study specifically attempts to see how having high and low gi meals impact on blood glucose levels and energy regulation in asians. the study is important in that it will be the first of its kind in the whole body calorimeter and enable us to compute the rate of fat synthesis and how it is modulated when subjects are fed a high gi diet (increased glucose excursions) and a low gi diet ( blunted glucose) over 24 hours in healthy asians. obesity and diabetes rates are increasing exponentially in asian populations and singapore is no exception. devising ways and means to staunch the escalation is therefore a priority. the findings of the research will contribute towards the long-term objectives of developing asian specific dietary guidelines for weight and glycaemic control. the study data will also be important for the provision of practical food-based advocacy for better weight and glycaemic control in singaporeans.

Eligibility criteria:
inclusion criteria: * chinese, male * age between 21-40 years * body mass index between 17 to 25 kg/m2 * normal blood pressure (\<140/80 hgmm) * fasting blood glucose \< 6 mmol/l exclusion criteria: * having any metabolic diseases (such as diabetes, hypertension etc) * on prescription medication * having glucose 6-phosphate dehydrogenase deficiency (g6pd) * partaking in sports at the competitive and/or endurance levels * allergic/intolerant to any of the test foods * intentionally restricting food intake * smoking
post-trial tuberculosis case finding: a substudy of covpn 3008

Conditions: Tuberculosis

Summary: this substudy aims to identify cases of tuberculosis after the covpn 3008 clinical trial is completed.

this observational substudy will involve participants from the covpn 3008 trial, regardless of their hiv status, to study tuberculosis (tb). at the start, all participants will be screened for tb, even if they have no symptoms. they will receive chest x-rays and provide sputum samples for tb testing using xpert ultra, smear microscopy, and culture. the study has two main groups. group 1 includes participants with confirmed tb, and group 2 includes participants without tb who will act as controls. participants with confirmed tb will start treatment and have a first follow-up visit on day 4 to reassess tb symptoms and collect blood samples. a second follow-up visit will take place at week 26 to evaluate their treatment progress, clinical outcomes, and tb status, ensuring they receive the necessary care. participants without tb will have a single follow-up visit on day 4 to reassess tb symptoms and collect blood samples. the study aims to identify potential biomarkers of tb by analyzing blood samples from both cases and controls, focusing on gene expression linked to tb, including hidden (subclinical) tb.

Eligibility criteria:
inclusion criteria: * enrollment into the covpn 3008 clinical trial. * able and willing to complete the informed consent process: volunteer demonstrates an understanding of this substudy. * willingness to discuss tb status, undergo related testing/monitoring labs, and receive referrals for tb care. exclusion criteria: * investigator's concern for difficulty with venous access based on clinical history and physical examination.

Keywords: tb
14-day quadruple therapy versus triple therapy in hp eradication

Conditions: Gastritis H Pylori

Summary: in this prospective randomized-controlled study, treatment-naive h. pylori-infected patients are randomized to receive either standard triple therapy or sequential therapy. the aim is to compare the efficacy of concomitant quadruple therapy with standard triple therapy as a first line treatment for h. pylori infection in tunisian patients.

this study includes male and female patients aged between 18 and 65, with documented hp infection and who have had no previous eradication treatment.the diagnosis of hp infection was made through an anatomopathological study. gastric biopsies were taken according to the sydney protocol: two fundics in one pot, two antrals and one at the angle of the lesser curve in a second pot. the biopsies were studied by an experienced anatomopathologist. the included patients were randomly divided into two treatment groups according to a 1: 1 ratio: the first group received concomitant quadruple therapy (qc) combining a double dose ppi (esomeprazole: 40 mg x 2 per day) with the amoxicillin (1 g x 2 per day), metronidazole (500 mg x 2 per day) and clarithromycin (500 mg x 2 per day) for 14 days. the second group received triple therapy (tt) combining a double dose ppi (esomeprazole: 40 mg x 2 per day) with amoxicillin (1 g x 2 per day) and clarithromycin (500 mg x 2 per day) for 14 days. h. pylori eradication was assessed by the 13c-urea breath test 8 weeks after treatment.

Eligibility criteria:
inclusion criteria: * patients aged between 18 and 65, with documented hp infection. exclusion criteria: are excluded patients: * with cirrhosis. * with renal failure (serum creatinine\> 120 µmol / l). * having complicated peptic ulcer (stenosis or hemorrhage or perforation) in an acute phase. * having severe psychiatric disorders. * having had gastric surgery in their history. * having already received an hp eradication treatment. * having received an antibiotic within the last two weeks. * who are allergic to one of the antibiotics used in the anti-hp cure. * who are drug addicted.

Keywords: breath tests helicobacter pylori
the effects of music on neck pain

Conditions: Pain, Chronic

Summary: the effects of passive music listening on pain, anxiety and quality of life in patients with chronic neck pain in addition to physical therapy will be examined.

the aim of the study was to investigate the effects of passive music listening in addition to physical therapy on pain, anxiety and quality of life in patients with chronic neck pain.there is no study in the literature examining the relationship between music listening and physical therapy in chronic back pain. since our study will be the first to investigate the subject, we foresee that it is scientifically important and will shed light on future studies. in addition, national or international publications are planned after the study is completed.

Eligibility criteria:
inclusion criteria: * patients with neck pain for more than 3 months with pain severity of 5 or greater according to the visual analogue scale (vas) exclusion criteria: * individuals who regularly take painkillers or anti-depressant and cortisone; and individuals having severe chronic illness and spine surgery were excluded from the study
randomized evaluation of machine learning assisted radiation treatment planning vs standard radiation treatment planning

Conditions: Cancer Head Neck; Cancer, Head; Cancer Neck

Summary: the purpose of this study is to determine the magnitude of clinical benefit achieved through machine learning assisted radiation treatment planning (mlap) on post-treatment clinical outcomes such as acute toxicity and patient reported outcomes.

this is a randomized phase iii trial to evaluate the effectiveness of mlap compared to standard of care. patients will undergo a randomization procedure with a variable allocation ratio where the first third of patients are randomized 3:1 in favor of soc, the next third randomized 1:1, and the last third randomized 1:3 in favor of mlap. this is done to give dosimetrists time to optimize the mlap workflow. since the treatment team may learn to improve their treatment planning process in the soc arm through interactions with rapidplan, as a sensitivity analysis, the primary and secondary goals will be re-analyzed including time of registration as a moderator of the treatment effect.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years at time of registration * receiving curative intent intensity modulated radiotherapy for head and neck primary cancer at the discretion of the treating medical doctor (md) * provide written informed consent or allow legally authorized representative to consent on behalf of a participant * willing to return to enrolling institution for study follow-up visit exclusion criteria: * incarcerated * unable to provide informed consent * prior head and neck (h\&n) radiation therapy * planned radiation dosing lk\ 76 gy

Keywords: mlap (machine learning adaptive planning) rapidplan
pharmaceutical consultation and exchange between the pharmacy and the hospital

Conditions: Diabetes

Summary: investigators hypothesize that the implementation of a hospital pharmacy consultation and the transmission of its report to pharmacies may improve knowledge, adherence and encourage the development of pharmacist medication reviews. a before-and-after study of the implementation of pharmaceutical consultations will allow the investigators to evaluate the validity of the hypothesis.


Eligibility criteria:
inclusion criteria: * adult patient admitted in the endocrinology service for a type 2 diabetes who has more than 5 concomitant treatments * adult patient that is being discharged for a return home * good comprehension of french exclusion criteria: * bad comprehension of french

Keywords: pharmaceutical consultations adherence
a study to investigate the efficacy and safety of eribulin in korean breast cancer participants

Conditions: Locally Advanced or Metastatic Breast Cancer

Summary: the primary objective of the study is to observe efficacy in terms of progression-free survival rate at 6 months in eribulin-treated breast cancer participants retrospectively.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of locally advanced or metastatic breast cancer * participants who were treated with eribulin between 01 june, 2014 and 31 december, 2016 exclusion criteria: * not applicable

Keywords: breast neoplasms metastatic breast cancer e7389
detection of pathological lymphocytes in patients with autoimmune disease

Conditions: Arthritis, Rheumatoid

Summary: this study will help the investigators design a method to detect the disease-causing immune cells in patients with rheumatoid arthritis (ra). such methods are not currently available, but if successful, would help scientists to better understand the causes of ra.

the investigators are interested in learning about the immune cells in the blood that contribute to disease in patients with rheumatoid arthritis (ra). they have developed a method for identifying a specific type of immune cells that can react against normal tissues in the body. in this study, the investigators will enroll ra patients from the university of minnesota clinics, collect blood samples from enrolled patients, and process the blood samples to isolate dna, rna, serum, and blood cells. they will use the serum to detect whether specific autoantibodies (anti-cyclic citrullinated peptide, or anti-ccp) are present. in cases where anti-ccp antibodies are detected, the investigators may quantify the numbers of immune cells present that contain receptors with the same anti-ccp specificity. they may also test whether the numbers of immune cells with these receptors correlate with measures of disease activity in ra patients.

Eligibility criteria:
inclusion criteria: * diagnosis of rheumatoid arthritis exclusion criteria: * use of rituximab immediately prior to visit * pregnancy
effect of using adaptive seating equipment on hand function

Conditions: Cerebral Palsy

Summary: objective: the purpose of this study was to evaluate the effect of adaptive swiss ball seating as an alternative for standard chair seating on hand function in children with hemiparesis. subjects: a total of 30 spastic hemiparetic cerebral palsied children (19 boys and 11 girls), aged 3-6 years participated in this study. they were randomly assigned into control and study groups of equal numbers each consisted of fifteen children (n=15). methods: peabody developmental motor scales 2 (pdms-2) was used to evaluate each child individually before and after three successive months of treatment (3 sessions per week), to assess 2 subtests (the grasping skills and visual motor integration skills) for all children of both groups. control group who received a specially selected physical therapy program for hand function on a standard chair seating. study group who received the same selected program for hand function on adaptive swiss ball seating.

the aim of this study was to evaluate the effect of adaptive swiss ball seating as an alternative for standard chair seating on hand function in children with hemiparesis. in this study, a total of 30 spastic hemiparetic cerebral palsied children (19 boys and 11 girls) aged 3-6 years, they were selected from general hospitals and private centers in kafr el-sheikh government, randomly assigned to either the control group (n=15), who received a specially selected physical therapy program for hand function on standard chair seating, or the study group (n=15), who received the same selected program for hand function but on adaptive swiss ball seating. both groups received 3 sessions per week for 3 successive months. peabody developmental motor scales 2 (pdms-2) was used to evaluate each child individually before and after three successive months of treatment, to assess 2 subtests (grasping skills and visual motor integration skills).

Eligibility criteria:
inclusion criteria: * children with hemiparetic cerebral palsy. * the age of the selected children ranged from 3 to 6 years old. * degree of spasticity ranged from 1 to 1+, according to modified ashworth' scale (bohannon and smith, 1987) * they were able to follow instructions and understand commands included in both assessment and training procedures. * they were able to sit independent with trunk control. exclusion criteria: * children exposed to orthopedic surgeries or potolinium toxins injection in the last 6 mounth before intervention. * children with fixed upper limb deformities * children with hearing or visual impairments.
inflammatory myopathies in primary sjögren's syndrome

Conditions: Primary Sjögren Syndrome

Summary: the amiss study will characterize the features of muscle disease in patients with primary sjogren's syndrome (pss).

muscle disease is associated with pss, but this association is not well defined. the amiss study, a retrospective observational multicentric study, will recruit patients with pss and muscle involvement in order to characterize in details the features of this association (epidemiological aspects, clinical presentation, biological, radiological and histological findings, treatments and outcomes).

Eligibility criteria:
inclusion criteria: * diagnosis of primary sjögren's syndrome according to the acr/eular classification criteria * inflammatory muscle involvement, as diagnosed by the treating physician exclusion criteria: * diagnosis of inflammatory myopathy before the diagnosis of pss
views and attitudes of oncologists and geriatricians on the use of chemotherapy and hormone therapy in treating older and/or frail women with breast cancer

Conditions: Breast Cancer

Summary: rationale: a patient's age, health, and ability to perform daily activities may affect which treatment options are offered by doctors to older and/or frail women with breast cancer. purpose: this clinical trial is studying the views and attitudes of oncologists and geriatricians on the use of chemotherapy and hormone therapy in treating older and/or frail women with breast cancer.

objectives: * evaluate the attitudes and perspectives of 150 oncologists and 150 geriatricians or primary care providers regarding the adjuvant treatment of older women with breast cancer of varying ages, health, and functional status. * determine whether homogeneity exists in treatment recommendations. * determine the relative impact of chronological age, baseline health, and functional status on treatment recommendations. outline: participants complete a 25-minute online survey regarding their treatment recommendations for older women with breast cancer of varying ages, health, and functional status. projected accrual: a total of 300 participants will be accrued for this study.

Eligibility criteria:
disease characteristics: * participants must meet 1 of the following criteria: * oncologist: * must have been in practice ≥ 2 years * must have ≥ 25 postmenopausal breast cancer patients on adjuvant hormonal therapy * cannot work for an advertising agency, market research company, manufacturer or distributor of pharmaceutical products, a pharmacy, drug store, or the fda * geriatrician: * must have been in practice ≥ 2 years * must be a general practitioner, family practitioner, internal medicine specialist, or geriatrician and received a certificate of added qualification in geriatric medicine and/or treating at least 5 postmenopausal patients who have a history of breast cancer or are currently undergoing treatment for breast cancer * cannot work for an advertising agency, market research company, manufacturer or distributor of pharmaceutical products, a pharmacy, drug store, or the fda patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: breast cancer
radiofrequency for the treatment of peripheral vascular occlusive disease of the lower extremities

Conditions: Peripheral Vascular Disease

Summary: the purpose of this study is to evaluate the safety and efficacy of the minnow medical grst peripheral catheter system in the treatment of new lesions in the superficial femoral artery or the popliteal artery.


Eligibility criteria:
inclusion criteria: * patient is ≥18 years of age * patient is rutherford category 2-4 * de novo lesion in the sfa or popliteal artery with a diameter stenosis ≥50% * target lesion is a de novo occlusion that can be successfully pre-dilated resulting in a lesion of \<99% * target lesion stenosis has a length of ≤100 mm based on visual assessment * target vessel reference diameter is ≥3.0 mm and ≤7.0 mm based on visual assessment * angiographic evidence of distal runoff defined as minimum one (1) patent tibial artery with a straight flow to the foot * patient is willing and able to provide written informed consent prior to any study specific procedure * patient is willing and able to comply with specified follow-up evaluations at the specified times exclusion criteria: * any prior intervention in the intended target lesion including 10 mm proximal or distal from the intended treatment area * evidence of thrombus in the target vessel * prior ipsilateral or contralateral lower limb arterial bypass * treatment of ipsilateral lesions during the index procedure or planned treatment after the index procedure * target lesion is severely calcified * any known allergies and / or intolerances to the following: asa, clopidogrel, heparin, contrast agents (that cannot be adequately pre-medicated). * any planned surgery within 30 days of the study procedure. * renal failure (serum creatinine \> 2.0 mg/dl) * female with childbearing potential without a negative pregnancy test * patient has had an organ transplant * patient is currently participating in an investigational drug or device study which has not reached the primary endpoint yet or which clinically interferes with the endpoints of this study * in the investigator's opinion, the patient has a severe co-morbid condition(s) that could limit the ability to participate in the study
hand scleroderma lived experience scale in individuals with systemic sclerosis

Conditions: Systemic Sclerosis (SSc); Hand Function

Summary: the aim of this study was to examine the turkish validity and reliability of the hand scleroderma lived experience scale (hande scale) questionnaire in individuals with ssc.


Eligibility criteria:
inclusion criteria: * being diagnosed with systemic sclerosis by a rheumatologist * being 18 years of age or older, exclusion criteria: * presence of neurological disease * presence of any orthopedic problem that will affect functionality * presence of orthopedic surgery history * inability to speak or understand turkish fluently. * presence of psychiatric disease that will affect cooperation. * severe neurological disease that will affect hand functions (peripheral nerve lesion, trauma, operation, cerebrovascular accident). * heart failure and lung pathology that will affect daily living activities.
cd19 and cd22 targeted car-t cell therapy for relapsed/refractory b cell leukemia and lymphoma

Conditions: Leukemia, B-cell; Lymphoma, B-Cell

Summary: this is a single arm study to evaluate the efficacy and safety of cd19 and cd22 targeted car-t cells therapy for patients with relapsed/refractory b cell leukemia and lymphoma.

although the anti-cd19 car-t cell therapies have gained significant results in patients with relapsed and refractory b-cell hematologic malignancies. there are patients who resisted anti-cd19 car-t cells or with cd19 negative relapse. to make further improvement, we launch such a clinical trial using cd19 and cd22 targeted car-t cells for patients with relapsed and refractory b cell leukemia and lymphoma to evaluate the efficacy and safety of cd19 and cd22 targeted car-t cell therapy.

Eligibility criteria:
inclusion criteria: 1. signed written informed consent 2. diagnose as relapsed and refractory b cell leukemia and lymphoma, and meet one of the following conditions: 1. failed to standard chemotherapy regimens; 2. relapse after complete remission, high-risk and / or refractory patients ; 3. relapse after hematopoietic stem cell transplantation; 3. for patients with ph + all, the following conditions must be met: those who have received a standard induction chemotherapy regimen and who have not achieved complete remission after tki treatment or have relapsed after remission (cannot tolerate tki treatment or have contraindications to tki treatment or the presence of tki class) except for drug resistant patients)； 4. evidence for cell membrane cd19 and cd22 expression； 5. all genders ，ages: 2 to 75 years； 6. the expect time of survive is above 3 months; 7. kps\>60； 8. no serious mental disorders ; 9. left ventricular ejection fraction ≥50% 10. sufficient hepatic function defined by alt/ast≤3 x uln and bilirubin≤2 x uln; 11. sufficient renal function defined by creatinine clearance≤2 x uln; 12. sufficient pulmonary function defined by indoor oxygen saturation≥92%; 13. with single or venous blood collection standards, and no other cell collection contraindications; 14. ability and willingness to adhere to the study visit schedule and all protocol requirements. exclusion criteria: 1. previous history of other malignancy; 2. presence of uncontrolled active infection; 3. evidence of disorder that need the treatment by glucocorticoids; 4. active or chronic gvhd； 5. the patients treatment by inhibitor of t cell； 6. pregnant or breasting-feeding women; 7. any situation that investigators regard not suitable for attending in this study (e.g. hiv , hcvinfection or intravenous drug addiction) or may affect the data analysis.

Keywords: cd19 cd22 car-t