Kornimate/medical-research-clean huggingface dataset:
effect of oxygen in normoxaemic copd patients who desaturate during exercise

Conditions: COPD

Summary: in copd patients with desaturation during exercise, several studies have shown an acute beneficial effect of supplemental oxygen. therefore, both the british thoracic society and the american thoracic society guidelines recommend supplemental oxygen to patients who desaturate \>4% and to below 88-90%. however, long-term studies have not been able to support this intervention. in this study of copd patients, who desaturate and participate in a 7-week pulmonary rehabilitation programme, we examine the effect of supplemental oxygen on exercise tolerance, health status, and exacerbation rates. in a randomised design patients trained either with room air or with 2 litres oxygen per minute from a portable oxygen concentrator. all patients were asked to exercise every day for 30 minutes.

in copd patients with desaturation during exercise, several studies have shown an acute beneficial effect of supplemental oxygen. therefore, both the british thoracic society and the american thoracic society guidelines recommend supplemental oxygen to patients who desaturate \>4% and to below 88-90%. however, long-term studies have not been able to support this intervention. in this study of copd patients, who desaturate and participate in a 7-week pulmonary rehabilitation programme, we examine the effect of supplemental oxygen. using a randomised design, patients trained either with room air (control) or with 2 litres oxygen per minute from a portable oxygen concentrator. all patients were asked to exercise every day for 30 minutes. primary effect parameters: endurance shuttle walk time at baseline, 7 weeks (after intensive supervised rehabilitation), 3 months (after maintenance training twice a month), and after 6 months. secondary effect parameters: st. george respiratory questionnaire (health status); usage of oxygen, exacerbations requiring medical treatment, hospitalisation and mortality in the same periods.

Eligibility criteria:
inclusion criteria: * copd * participate in a 7-weeks pulmonary rehabilitation programme * desaturate \>4% to less than 90% during endurance shuttle walk test exclusion criteria: * long-term oxygen therapy

Keywords: copd oxygen copd rehabilitation exercise
treatment of bacterial vaginosis (bv) with tinidazole

Conditions: Bacterial Vaginosis

Summary: we are trying to determine if treatment of bacterial vaginosis with tinidazole is better than treatment with metronidazole

bacterial vaginosis (bv) is the most prevalent cause of symptomatic vaginal discharge in the u.s. and has been associated with complications including preterm delivery of infants, pelvic inflammatory disease (pid), urinary tract infections (uti) and acquisition/transmission of sexually transmitted diseases (stds) including human immunodeficiency virus (hiv). control of bv has been advocated as a means of decreasing the prevalence of these complications. however, the etiology of bv remains unknown and the current treatment regimens are inadequate in terms of initial cure and recurrence rates. although not currently licensed in the u.s., tinidazole is an antimicrobial related to metronidazole which has shown promise for the treatment of bv in european studies and is widely used worldwide for the treatment of trichomoniasis including infections which are resistant to metronidazole. we hypothesize that qualities of tinidazole such as its longer half-life and its seemingly superior side effect profile as compared to oral metronidazole will result in its being a more efficacious drug for the treatment of bv than the currently available options. the specific aims of this project are: 1. to compare the efficacy of two different doses of tinidazole with oral metronidazole for the initial treatment of symptomatic bv as well as short-term recurrence rates 2. to compare the side effect profiles of tinidazole versus metronidazole in the treatment of bv 3. to compare drug levels of tinidazole and metronidazole in the vaginal secretions and correlate with microbiologic cure of bv as well as rates of recurrence.

Eligibility criteria:
inclusion criteria: * women be at least 18 years of age * have symptoms of vaginal odor and or/discharge * meet the clinical (amsel) criteria for bv * willing to participate in research exclusion criteria: * presence of another vaginal infection or std * allergy to metronidazole * pregnant or nursing * use of oral or intravaginal antibiotics within the past 2 weeks * hiv or other chronic disease * inability to keep return appointments

Keywords: bacterial vaginosis tinidazole
precede-proceed model-based program on genital hygiene behaviors

Conditions: Genital Infection Female

Summary: the study was conducted to investigate the effect of a training program based on the precede-proceed model on improving genital hygiene behaviors.it was carried out using experimental research design with pre-test and post-test, randomized and a control group. the study was conducted at erzurum saltuklu family health center between june 2017 and january 2018. of the women with genital infections, 120 women were included in the study, of which 60 were in the experimental group and 60 were in the control group. the data were collected by "personal information form," "genital hygiene knowledge, attitude and beliefs, questionnaire" and "genital hygiene behavior inventory". in study, genital hygiene training intervention prepared according to the precede-proceed model was applied to the women in the experimental group. the women in the experimental group were measured at three different times: pre-test before training, post-test through training completition, and follow-up test after 4 weeks. the women in the control group did not receive any training intervention, the pre-test at the first encounter in the family health center and the post-test 5 weeks later.


Eligibility criteria:
inclusion criteria: * between the ages of 18-49, * married, * at least primary school graduate, * no mental and communication problems, * no chronic disease, * non-pregnant. exclusion criteria: * women who have entered menopause, * women who had received any training on genital hygiene before

Keywords: genital hygiene behavior women's health precede-proceed model health education nursing
clostridioides difficile and frailty

Conditions: Frail Elderly; Clostridioides Difficile; Geriatric Assessment; Faecal Microbiota Transplantation; Aged

Summary: cdi is a major cause of antibiotics-associated diarrhoea. more than half of the patients affected are 70 years or older and frail. mortality among older patients with cdi is high. faecal microbiota transplantation (fmt) is a life-saving therapy which reduce symptom duration and mortality. the fmt procedure usually requires hospital attendance, and frail old patients often are too weak to tolerate transportation to hospital and may therefore be withheld treatment. the overall aim of the present project is to investigate whether a multimodal geriatric assessment, treatment and follow-up of frail older patients with cdi can improve patient survival compared with standard care. in particular, it is explored whether an expanded collaboration between the geriatric wards, early clinical assessment and home treatment with fmt contribute to increased patient survival rates.

this is a multi-centre randomised clinical trial that test two established care pathways in the assessment and treatment of old patients with clostridioides difficile infection (cdi). we aim to include 216 patients aged 70 years or older with clostridioides difficile infection. patients are randomised in a 1:1 ratio to either geriatric tailored intervention or standard care as defined by national clinical guidelines. the primary outcome is 90-day survival.

Eligibility criteria:
inclusion criteria: 1. patients aged ≥ 70 years and living in the central denmark region 2. positive pcr test clostridioides difficile exclusion criteria: 1. previously included 2. \> 4 episodes of cdi 3. fmt treatment 8 weeks before date of positive pcr test for clostridioides difficile. 4. end of life care defined as follows: end of life care treatment has been initiated before positive pcr test for cdi and the patient has days/few weeks of survival (investigator consensus based on review of electronic medical journal (emr)) 5. patients already received comprehensive geriatric assessment, defined as follows: when diagnosed with cdi affiliated with the department of geriatrics (in- or outpatient activity).
a family-centered intervention program for preterm infants: effects and their biosocial pathways

Conditions: Premature Birth

Summary: four hypotheses will be tested in this study: 1. the intervention group performs better in child, parent and transactions outcomes than the control group throughout the follow-up period. 2. the intervention group shows greater changes in early neurophysiological brain functions and transactions within the family that lead to better neurodevelopmental outcomes than the control group. 3. certain polymorphisms of the dopamine-related genes are associated with the neurodevelopmental outcomes in vlbw preterm infants. 4. very low birth weight preterm infants carrying more genetic plasticity in the dopamine-related genes may benefit more from the interventions than those carrying less genetic plasticity.

a total of 275 vlbw preterm infants (269 participants and 6 pilots) were recruited at three medical centers in northern and southern taiwan and were randomly assigned to the fcip or ucp group. outcome assessments included primary (neurobehavioral development) and secondary measures (neurophysiological performance, parents' stress and transactions within the family). the neurophysiological and transactions data were examined for whether they mediate intervention effects on child development. in addition, these infants 219 vlbw preterm infants and 118 term infants in our prior intervention studies were collected buccal cells for assessment of the polymorphisms of dopamine-related genes, which are involved in the neurotransmission of cognitive, sensorimotor and behavioral-emotional systems and postulated to be associated with several developmental and psychiatric illnesses. the polymorphisms of dopamine-related genes were examined for potential moderating influence on the effects of the intervention for child development.

Eligibility criteria:
inclusion criteria: * birth body weight \< 1500 grams * gestational age \< 37 weeks * parents of taiwan nationality, married or together at delivery, and northern family residing in greater taipei and southern family residing in greater tainan, kaohsiung, or chiayi exclusion criteria: * severe neonatal and perinatal diseases (e.g., seizures, hydrocephalus, meningitis, grade iii-iv ivh and grade ii nec) * congenital or chromosome abnormality * mother \< 18 years, with mental retardation or history of maternal substance abuse at any time (smoking, alcohol, and drug) terminated criteria: * diagnosis of brain injury (e.g., pvl, stage iv rop or greater) * severe cardiopulmonary disease requiring invasive or non-invasive ventilator use at hospital discharge * hospital discharge beyond 44 weeks' post-menstrual age.

Keywords: environment gene intervention neurodevelopment pathways preterm infants
adjuvant chemotherapy for high malignant prostate cancer

Conditions: Prostate Cancer; Radiation Therapy; Chemotherapy; Gleason Score

Summary: this study aims to evaluate the efficacy of adjuvant docetaxel chemotherapy following radical radiotherapy in patients with localized high-grade prostate cancer. eligible participants include those diagnosed with prostate cancer confirmed by biopsy or surgical pathology, with a gleason score of 9-10 or containing a gleason 5 component, and no evidence of distant metastasis. patients will be divided into two groups: the standard treatment group receiving only radical treatment (radiotherapy or surgery), and the standard treatment plus chemotherapy group, receiving four to six cycles of docetaxel chemotherapy after standard treatment. the primary endpoint is failure-free survival (ffs), with secondary endpoints including biochemical relapse-free survival (brfs), metastasis-free survival (mfs), overall survival (os), and assessment of adverse events the study aims to better understand the impact of adjuvant chemotherapy on the prognosis of patients with high-risk prostate cancer and determine whether it improves survival outcomes.


Eligibility criteria:
inclusion criteria: 1. histologically confirmed prostate cancer diagnosed by biopsy or surgery with a gleason score of 9-10 (gg grade 5) or containing gleason 5 components. 2. no evidence of distant metastasis confirmed by imaging. 3. expected to receive standard radical treatment or postoperative radiotherapy. 4. estimated survival time greater than 12 months. 5. aged ≥ 18 years. 6. karnofsky performance status (kps) ≥ 80. 7. adequate blood count: white blood cell ≥ 3.5 × 10\^9/l, neutrophils ≥ 1.5 × 10\^9/l, platelets ≥ 100.0 × 10\^ exclusion criteria: 1. history of malignant tumors (except those cured for more than 5 years). 2. previous abdominal radiation therapy. 3. weight loss \> 10% within the past 6 months. 4. pre-existing or concomitant bleeding disorders. 5. active infections. 6. significant cardiovascular disease (e.g., controlled hypertension, unstable angina, nyha class ≥ ii congestive heart failure, unstable symptomatic arrhythmias, or ≥ ii peripheral vascular disease) or any condition deemed intolerable to chemotherapy by the oncology department.
mycophenolate mofetil in membranous nephropathy and focal segmental

Conditions: Glomerulonephritis, Membranous; Glomerulosclerosis, Focal

Summary: this is a prospective randomized open-label pilot study to investigate the effect of mycophenolate mofetil treatment in patients with abnormal urine protein excretion due to membranous nephropathy (mn) or focal segmental glomerulosclerosis (fsgs). the change in urine protein excretion will be the primary outcome studied. the treatment regimen comprising prednisolone and mycophenolate mofetil will be compared with prednisolone and chlorambucil in mn, and compared with prednisolone in fsgs. the study duration will be 12 months for each patient.


Eligibility criteria:
inclusion criteria: * abnormal urine protein excretion and biopsy-proven idiopathic membranous nephropathy or focal segmental glomerulosclerosis

Keywords: idiopathic membranous nephropathy or focal segmental glomerulosclerosis
proton pump inhibitors effects on dyspepsia during ramadan fasting

Conditions: Dyspepsia

Summary: evaluate the interest of proton pump inhibitors in subjects with or with gi symptoms who intend to observe fasting in ramadan. the investigators will compare the effectiveness of proton pump inhibitors to prevent or reduce the signs of dyspepsia during ramadan compared to placebo.

evaluate the interest of proton pump inhibitors in subjects with or with gi symptoms who intend to observe fasting in ramadan. investigators will compare the effectiveness of proton pump inhibitors to prevent or reduce the signs of dyspepsia during at least ramadan compared to placebo. the study will be conducted at least from april 2019 to at least june 2030.the study is prospective, two parallel groups, randomized controlled and double blind.

Eligibility criteria:
inclusion criteria: - exclusion criteria: * diagnosed gastroduodenal ulcer

Keywords: fasting proton pump inhibitors dyspepsia
identification of acute intermittent porphyria modifying genes

Conditions: Acute Intermittent Porphyria (AIP)

Summary: this study proposes to identify the predisposing/protective modifying genes that underlie the acute attacks in symptomatic patients with acute intermittent porphyria (aip), an autosomal dominant inborn error of heme biosynthesis.


Eligibility criteria:
inclusion criteria: * willing and able to give informed consent * 12 years of age or older * willingness to provide blood/saliva and urine samples, and clinical information * a member of an aip family, defined as (must meet one of the following): 1. proband: possesses an aip pathogenic mutation and is/has been symptomatic (experienced acute attacks in the opinion of the investigator) 2. parents (no known hmbs mutations or heterozygote with familial mutation) 3. first, second, or third degree relative of (a) or (b)
elucidating taar-1, dopamine, and norepinephrine in binge eating disorder using solriamfetol

Conditions: Binge-Eating Disorder

Summary: engage (elucidating taar-1, dopamine, and norepinephrine in binge eating disorder using solriamfetol) is a phase 3, randomized, double-blind, placebo-controlled, multicenter trial to assess the efficacy and safety of solriamfetol for the treatment of binge eating disorder (bed) in adults.

eligible subjects must have a diagnosis of bed according to the diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) criteria. subjects will be randomized in a 1:1:1 ratio to receive solriamfetol (150 or 300 mg) or placebo, once daily for 12 weeks.

Eligibility criteria:
inclusion criteria: * primary diagnosis of bed according to dsm-5 criteria. * provides written informed consent to participate in the study before the conduct of any study procedures. * male or female, aged 18 to 55 inclusive. exclusion criteria: * prior exposure to solriamfetol/sunosi, through either a clinical study or prescription. * unable to comply with study procedures. * medically inappropriate for study participation in the opinion of the investigator.

Keywords: binge eating disorder bed solriamfetol sunosi axsome non-stimulant therapy dopamine norepinephrine reuptake inhibitor trace amine-associated receptor 1 (taar1) agonist
surgery vs botulinum toxin on quality of life in stroke patients: randomized trial

Conditions: Stroke

Summary: we present a research project in the form of a controlled clinical trial with the aim of analyzing and demonstrating whether the surgical treatment of upper limb spasticity is an effective and efficient measure to improve dependence and quality of life perceived by patients with sequelae of stroke and therefore, should be included in the therapeutic protocols, in which it is not usually contemplated, as a complement or alternative to traditional treatment with botulinum toxin, rehabilitation and occupational therapy.

cerebrovascular accident (cva) or "stroke" is the leading cause of permanent disability in adulthood and many patients require lifelong medical treatment and assistance from other people for the development of their daily activities. the repercussion in the family, professional, labor and social fields is enormous, producing a very important economic expense. the usual treatment of spastic upper limb secondary to stroke is rehabilitation, occupational therapy and periodic injection of botulinum toxin, and surgical correction is not usually considered. a two-arm randomized clinical trial \[surgical treatment (n=22) vs. botulinum toxin (n=22)\] is proposed with the aim of investigating the efficacy and efficiency of surgery for upper limb spasticity with respect to treatment with botulinum toxin in patients with established spastic sequelae after stroke. we will evaluate the effect on functionality and "hygienic" changes; the impact on quality of life, sleep quality, anxiety and depression; as well as on brain activity by functional magnetic resonance imaging, at baseline and at 6 and 12 months follow-up. the health and care costs of the established groups of patients will also be evaluated. this research is framed in the context of chronic diseases, aging and patients with functional and mobility difficulties. the results of this work are expected to have a great impact due to the high prevalence of the disease, the severe disability it causes, and the number of patients who would benefit, in addition to the savings in healthcare resources. the incorporation of surgery into stroke care would change the current treatment paradigm, favoring the formation of multidisciplinary teams for the treatment of the disease.

Eligibility criteria:
inclusion criteria: * patients of legal age, with spasticity in the upper limb due to stroke, with a minimum evolution time of 12 months, who, after being informed orally and in writing of the objectives of the study, sign the informed consent form (themselves or their legal representatives). exclusion criteria: * absence of consent, refusal of possible surgical treatment, stroke evolution time of less than 12 months, anaesthetic risk (asa) class iv or higher, presence of involuntary movements, inability to respond adequately to surveys, deformities that cannot be addressed by surgical treatment or inability to follow up for at least one year.

Keywords: spastic hand botulinum toxin surgery quality of life
study of the effect of compassion-based education program applied to mothers of children diagnosed with cerebral palsy

Conditions: Cerebral Palsy

Summary: purpose of the study; the aim of this study is to examine the effect of a compassion-based education program applied to mothers of children with cerebral palsy on compassion fatigue, depression, and psychological resilience.

the hypotheses of the study main hypothesis: "compassion-based education program adapted for adults" in increasing the compassion levels and psychological resilience of mothers of patients with cp; it is effective in reducing the level of depression. as sub-hypotheses: h1: the scores of the mothers who care for their children with cerebral palsy in the experimental group at the end of the application (post-test) and after the application (follow-up test) of the adult compassion scale are significantly higher than the scores they obtained before the application (pre-test). h2: the scores of the mothers who care for their children with cerebral palsy in the experimental group at the end of the application (post-test) and after the application (follow-up test) of the burns depression scale-turkish form are significantly lower than the scores they obtained before the application (pre-test). h3: the scores of the mothers who care for their children with cerebral palsy in the experimental group at the end of the application (post-test) and after the application (follow-up test) of the adult resilience scale are significantly higher than the scores they obtained before the application (pre-test).

Eligibility criteria:
inclusion criteria: * being the mother of a child with cerebral palsy exclusion criteria: * mothers who have children with cerebral palsy do not want to participate in the study and want to leave the study.

Keywords: serebral palsi depression resilience compassion
description of the functional evolution of diffuse infiltrating pneumonia associated with systemic scleroderma.

Conditions: Systemic Sclerosis

Summary: diffuse infiltrating pneumonia (dip) is a severe complication of systemic sclerosis and one of the leading cause of death in this condition. the main objective of this study is to prospectively describe the evolution of dip overtime and to find prognosis factors.


Eligibility criteria:
inclusion criteria: * systemic sclerosis * diffuse infiltrating pneumonia exclusion criteria: * infection * other lung diseases * non french native