Kornimate/medical-research-clean huggingface dataset:
rigid versus semirigid thoracoscopy in diagnosing pleural diseases: a randomized study

Conditions: Pleural Diseases

Summary: the purpose of our study was to compare the size and the quality of biopsy samples together with the diagnostic adequacy of semirigid thoracoscopy with that of rigid instrument in prospective, randomized fashion. the second aim was to compare safety and tolerability of both types of procedure, performed in local anesthesia with addition of intravenous sedation and analgesia.


Eligibility criteria:
inclusion criteria: * 18 or more years old * unilateral pleural effusion of unknown origin * pleural irregularities suspicious for pleural malignancy * referral for thoracoscopy after less invasive means of diagnosis had failed exclusion criteria: * uncontrolled bleeding tendency * unstable cardiovascular status * severe heart failure * ecog performance status 4 * persistent hypoxemia after evacuation of pleural fluid

Keywords: flex-rigid pleuroscopy pleural biopsy pleural effusion safety thoracoscopy
quality of life for children with zirconium anteroir crowns versus strip composite crowns

Conditions: Caries

Summary: early childhood oral health impact scale (ecohis) will be used for detection of oral health related quality of life for children using strip composite crowns versus zirconium crowns at 6 and 12 months


Eligibility criteria:
inclusion criteria: * healthy children cariuos primary anteroir teeth cooperative children exclusion criteria: * children with systemic diseases children with bad oral habits
nutritional strategies after muscle strain injuries

Conditions: Muscle Strain, Multiple Sites

Summary: muscle strain injuries are a particularly frequent type of sports injury in soccer, athletics, badminton/ tennis and cross-fit fitness, thereby affecting a broad range of popular leisure time activities. depending on severity, sports-active individuals may experience long-term functional impairment and pain. additionally, individuals having sustained one strain injury have a substantially increased risk of injuring the same muscle again. strain injuries lead to long-term, potentially permanent, loss of muscle mass, thereby weakening the muscle. muscle atrophy is likely a major factor in the high re-injury risk. further, strain injuries are associated with a long-term inflammatory response. in the current study, the investigators seek to study interventions to prevent the loss of muscle mass and elaborate on strategies to address the prolonged inflammation observed at the site of the injured muscle. the primary aim of this study is to investigate the effect of protein supplementation on the reduction of muscle atrophy following a severe muscle strain injury in comparison to a carbohydrate supplement. as a second purpose, this study aims to elaborate on findings of prolonged inflammation intra-/ intermuscular by large-scale protein analysis and the characterization of cells active at the site of injury. the study includes the following hypotheses: 1. protein supplementation administered in combination with a gradually increasing loading regime (rehabilitation with weekly progression in load/ intensity) will be effective in reducing the injury-related loss of muscle mass. 2. the environment at the site of injury is not only pro-inflammatory, but contains proteins associated with proteolysis. 3. cells belonging to the group of fibro-adipogenic progenitors will be accumulating intra- and inter-muscularly.


Eligibility criteria:
inclusion criteria: * sports-active men and women * acute muscle strain injury in either the calf muscles or the hamstring muscles * visible tear at the muscle-connective tissue interface visible on an us scan as a hypo-/ hyperechoic area exclusion criteria: * unwillingness to return to sports * claustrophobia * daily intake of non-steroidal anti-inflammatory drugs (nsaids) within 3 months prior to the strain injury * smoking * diagnosed or suspected type i or type ii diabetes * diagnosed or suspected connective tissue and/or rheumatic diseases * any observed organ dysfunctions

Keywords: muscle strain, atrophy, protein, rehabilitation
within my reach (wmr) adaptation

Conditions: Hiv; Violence

Summary: the purpose of this study is to adapt a relationship education program. the research team is adapting so that it is helpful for latino sexual minority men.


Eligibility criteria:
inclusion: * identify as latino/e/x or hispanic * age 18 years or older * currently reside in miami-dade county or broward county * identify as gay, bisexual, or other non-heterosexual identity * identify as a man * comfortable speaking english exclusion: * unable to provide consent * deemed that participating would be potentially harmful to the participant or research staff
evaluation of early retinal nerve injury in type 2 diabetes patients without diabetic retinopathy

Conditions: Diabetes Mellitus; Diabetic Retinopathy; Nerve Injury

Summary: the object of this study is to investigate the damage to the retinal nerve fiber layer (rnfl) and ganglion cell complex layer (gcl+) in diabetic patients without retinal microangioma as detected by fundus fluorescein angiography (ffa) and to determine the kind of nerve damage more likely to indicate early injury.

patients with type 2 diabetes mellitus and healthy volunteers will be included in our study. patients with retinal microangioma are excluded by ffa. the parameters around the optic disc and macular area of the above two groups are measured by optical coherence tomography (oct), and the results will be analyzed using the spss 22.0 software.

Eligibility criteria:
inclusion criteria: 1. patients with t2dm 2. patients without microangioma exclusion criteria: 1. patients with any other ocular disease that might affect retinal nerve injury 2. patients with optic neuropathy, age-related macular degeneration, retinal and choroidal disease, and retinal artery/vein occlusion. 3. patients with hypertension, hematopathy, neuropathy, and other systemic diseases causing retinal nerve changes. 4. patients with keratopathy, cataract, and vitreous hemorrhage were also excluded.
an electronic health record (ehr)-based comprehensive bone and soft tissue tumor registry

Conditions: Neoplasms, Connective and Soft Tissue; Bone Neoplasms

Summary: translational studies in cancer research can be impeded by the lack of high-quality clinical data that can be correlated with research questions. this is particularly true in the case of rare diseases, such as bone and soft tissue tumors. it is therefore the purpose of this study to create a prospective ehr-based clinical registry for individuals with bone and soft-tissue tumors.

primary objectives: i. to create a secure ehr-based registry to allow for the prospective collection of clinical and research data in a collection of rare diseases (bone and soft-tissue tumors). ii. to facilitate the identification and validation of clinical and molecular features that may be associated with prognosis and/or response to therapy in (subtypes) of bone and soft-tissue tumors. iii. to pilot a mechanism that will facilitate future collaboration between institutions for research and analysis of bone and soft-tissue tumors. iv. to standardize biospecimen collection for correlative biomarker analysis for patients undergoing treatment and surveillance for bone and soft tissue tumors at ohio state university. outline: this is an observational study. patients complete quality of life questionnaires and their medical records are reviewed. patients may also undergo collection of blood samples for up to 2 years, unless otherwise specified in the protocol.

Eligibility criteria:
inclusion criteria: * must have a diagnosis or presumed diagnosis of bone or soft tissue tumor as defined by the who classification of tumors of soft tissue and bone (4th ed.) * patient, or his/her designated power of attorney, must be able to understand and approve of the consent to participate. exclusion criteria: * prisoners are excluded from participation in the registry.

Keywords: sarcoma registry
comparison of posterior ocular changes between singleton pregnancy and multifetal pregnancy.

Conditions: Twin Pregnancy, Antepartum Condition or Complication; Retinal Vascular; Choroidal Effusion

Summary: it has been known that a pregnant women undergoes significant anatomical and physiological changes that mainly caused by hormonal and hematologic changes during pregnancy. due to advance in reproductive medicine, the incidence of multifetal pregnancy was increased to 3% of livebirth. multifetal pregnancies produce much more physiological changes in the body compared to the singleton pregnancies. physiologic ocular changes during pregnancy are the followings * melanogenesis of eyelid and facial skin * cellular alteration of lacrimal and meibomian gland * increased corneal thickness and corneal curvature * increased lens thickness * increased retinal vascular density * increased choroidal thickness decreased intraocular pressure -

from the literature review, there was only on study of ocular changes in twin pregnancies. alim et al evaluated the choroidal and retinal thickness in singleton versus twin pregnancies. they included 20 single and 20 twin pregnant women in their 3rd trimester with 20-age-matched healthy non-pregnant women as a control group. they found that there was an increase in choroidal thickness in the 3rd trimester of pregnancies and it was prominent in twin pregnancies. there was a statistically significant difference in choroidal thickness between pregnant and non-pregnant women, but not significant difference between singleton and twin pregnancies. the mean retinal nerve fiber layer thickness was significantly higher in the twin pregnancy group than in the singleton pregnancy group. however, no study of retinal vascular density in twin pregnancies has been published before.

Eligibility criteria:
inclusion criteria: * 24-37 years * 30-36 weeks of gestational age * clear ocular media * written informed consent exclusion criteria: * high risk pregnancies such as pre-eclampsia, gestational diabetic mellitus and asthma * history of refractive error, spherical equivalent \> 3 diopters * history of retinal diseases such as central serous chorioretinopathy and retinal vascular occlusion * history of intraocular inflammation or endophthalmitis * history of intraocular laser treatment * history of intraocular surgery
effect of exercise, endocannabinoids and ketones on cerebral metabolism in a cognitive disorders population

Conditions: Parkinson Disease; Alzheimer Disease

Summary: a two months intervention in which two groups of cognitive disorders, parkinson and alzheimer's disease, will receive 50g/day of a commercial mct supplement combined with supervised aerobic exercise 3 times/week. cognition and ketones will be assess before and after the intervention, along with endocannabinoids plasma concentrations.


Eligibility criteria:
inclusion criteria: * alzheimer's or parkinson disease diagnostic * stable medication associated with the disease * able to consent * presence of an accompanying person for the first and last visit. * ability to read and talk in french exclusion criteria: * mmse \< 20 * mct or coconut oil supplementation * coconut allergy * cannabis, thc or cbd consumption * excessive alcohol consumption * physical activity 3x/week * presence of an metallic object in the body * impossibility to lay in dorsal decubitus for 40 minutes * cardiac disease * any uncontrolled disease that could interfer with the project.

Keywords: alzheimer parkinson ketones medium chain triglycerides cognition brain
the effect of pain neuroscience education

Conditions: Student Education

Summary: the aim of this study is to examine the effect of pain neuroscience education (pne) on physiotherapy students' knowledge, attitudes and behaviors towards pain. a total of 52 physiotherapy students will be included in the study. students will be randomly randomly assigned to either pne group (n=26) or control group (cg) (n=26). the pne group will be receive a 70-min pne based on the explanations used in "explain pain". the cg group will be received an education about red-flags which are special screening questions for serious pathology. the red-flags education will be discussed tissue pathology and waddell's triage for back pain classification.neurophysiology and the biopsychosocial model will not be discussed. before, immediately after, and 2-months after the education sessions all students will be completed four questionnaires, the revised neurophysiology pain questionnaire (rnp-q), the health care providers' pain and impairment relationship scale(hc-pairs), and the red-flags questionnaire.


Eligibility criteria:
inclusion criteria: * volunteer to participate in study * to studying in physiotherapy * be able to read and understand turkish exclusion criteria: - having received pain neuroscience education
impact of limb remote ischemic preconditioning on mortality and quality of life during abdominal aortic aneurysm repair

Conditions: Abdominal Aortic Aneurysm

Summary: to investigate the influence of limb remote ischemic preconditioning (lrip) on mortality, hospitalization costs and quality of life in patients undergoing open infrarenal abdominal aortic aneurysm (aaa) repair.

remote ischaemic preconditioning may confer the cytoprotection in critical organs. the investigators have revealed that limb remote ischemic preconditioning (ripc) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (aaa) repair.few groups have investigated the long term influence of limb remote ischemic preconditioning.therefore, the investigators evaluated the impact of limb remote ischemic preconditioning on mortality, hospitalization costs and quality of life during elective abdominal aortic aneurysm repair in a prospective, randomized, controlled, single blind setting.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of abdominal aortic aneurysm * must be received open abdominal aortic aneurysm repair exclusion criteria: * age \>80 years old * acute coronary syndrome or myocardial infraction within 3 months * chronic obstructive pulmonary emphysema * angina pain within 48 hours of repair procedure * ejection fraction less than 40% * poor pulmonary function (pao2 \<60mmhg)
somatic symptoms in autism spectrum disorder: data integration

Conditions: Autism Spectrum Disorder; Somatic Symptom Disorder

Summary: autistic patients have higher chances commorbid somatic symptoms. therefore, it leads to more health-related concerns, such as autoimmune disease, gastrointestinal disease, cardiovascular disease, autonomic disorders. on average, autistic patient's life span is 16 years shorter than non-autistic patients. furthermore, autistic patients are not able to convey or communicate their somatic symptoms in a clear and comprehensive manner. this leads to unable to receive proper health care in a timely manner.


Eligibility criteria:
inclusion criteria: * asd group: diagnosed with dsm-5 autism spectrum disorder * clinical group: anxiety, depression, somatic disorder who are non-psychotic and non-organic * control group: healthy control without psychiatric disorder or chronic somatic symptoms * age between 15 and 70 exclusion criteria: * psychiatric disorders such as schezophrenia, mood disorder. * major physical disorder which can be potentially lethal * who cannot read or comprehend the survey and questionnaire
valsartan/hydrochlorothiazide combination vs amlodipine in patients with hypertension, diabetes, and albuminuria.

Conditions: Hypertension

Summary: the purpose of this study is assess if treatment with valsartan and a diuretic, hydrochlorothiazide, has beneficial effects in people with high blood pressure, diabetes, and albuminuria (protein in the urine) compared with amlodipine. in particular, the study will assess whether the treatment will decrease the stiffness of the blood vessels.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * elevated blood pressure and pulse pressure * albuminuria exclusion criteria: * severe hypertension * history of stroke, myocardial infarction, heart failure, chest pain, abnormal heart rhythm * liver, kidney (not caused by diabetes), or pancreas disease * type 1 diabetes or uncontrolled type 2 diabetes * allergy to certain medications used to treat high blood pressure other protocol-defined inclusion/exclusion criteria may apply.

Keywords: hypertension diabetes albuminuria valsartan hydrochlorothiazide amlodipine
comparison between local and imported skin prick testing result of rat and mouse allergen extracts

Conditions: Allergic Rhinitis Due to Animal Hair and Dander

Summary: in respiratory allergy patients, skin prick test results of local rat and mouse allergen extracts are not significant different from imported ones

many researches proposed that rodent deteriorate symptoms in patients with respiratory allergy who sensitized. the test that can identify rodent sensitization will be very useful. the investigators found lots of problems from imported mouse and rat allergen extract, eg. expensive cost and hard to find importing agency in thailand. making own local allergen extract will be the good solution for the country. this study aim to compare the results of locally rat and mouse allergen to imported ones.

Eligibility criteria:
inclusion criteria: * patients age 3 to 60 years old who diagnosed with asthma or allergic rhinitis * patient must not take these following medication at least 7 days before doing the skin prick test: antihistamine, oral corticosteroid (more than 20 mg/day of prednisolone), topical steroid that was apply on skin test area. exclusion criteria: * pateints who have other chronic underlying disease e.g. obesity, heart disease and liver disease * patient with allergic asthma who is still uncontrollable. * patient with active severe atopic dermatitis * patient who are pregnant or in lactating period * patient or parent deny to join in the study
effects of covid-19 induced deconditioning after long-term high intensity resistance exercise

Conditions: Osteoporosis; Sarcopenia

Summary: osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. dynamic-resistance exercise (drt) might be the most powerful agent to fight osteosarcopenia. indeed, in the present frost study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (hit)-drt on bone mineral density (bmd), sarcopenia and other health related parameters in osteosarcopenic men. however, after a short training break, covid-19 induced lock down prevented a re-start of the hit resistance exercise training in the frost cohort. the aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.


Eligibility criteria:
inclusion criteria: * participants of the frost study (nct03453463) exclusion criteria: * medication and diseases with potential impact on study outcomes during the last 26 weeks.
evaluation of viscosity of a vaginal moisturizer

Conditions: Vaginal Dryness; Menopausal Women

Summary: to evaluate the perception of viscosity of a vaginal moisturizer in postmenopausal women

a unicentric, blind, non-comparative clinical study to prove the perceived efficacy of the research product. it will be necessary 33 female research participants, aged between 45 and 70 years menopause with complaint of vaginal dryness. the participant will remain in the study for one day, making use of the research product in the research center. participants will be divided into 2 groups so that each group observes the viscosity (flow) of the test product in a different anatomical position (lying down and standing) immediately after application of the product, after 15 and 30 minutes. participants will respond to a subjective assessment using a standardized questionnaire to capture possible feelings of discomfort during the study. a gynecologist will be available to monitor the participants throughout the study.

Eligibility criteria:
inclusion criteria: * menopausal participants for at least 6 months; * participants with complaints of vaginal dryness; * skin integrity in the region of product analysis; * agreement to comply the procedures of the trial and attend the clinic on the days and times determined for applications and / or evaluations; * understanding, agreement and signing of the informed consent term. exclusion criteria: * use of anti-inflammatory / immunosuppressive / antihistamine drugs up to 3 weeks prior to selection; * pathologies and / or active skin lesions (local and / or disseminated) in the evaluation area; * immunosuppression by drugs or active diseases; * decompensated endocrinopathies; * relevant clinical history or current evidence of alcohol or other drug abuse; * known history or suspected intolerance to products of the same category; * intense sun exposure up to 15 days before evaluation; * gynecological treatment up to 4 weeks before evaluation; * other conditions considered by the researcher to be reasonable for disqualification of study participation.