Kornimate/medical-research-clean huggingface dataset:
survival outcomes of uterine malignancies in chinese population

Conditions: Endometrial Neoplasms; Survival

Summary: this study aims to determine survival outcomes (overall survival and progression-free survival) of primary uterine malignancies in china and relevant risk factors in a prospective cohort study.


Eligibility criteria:
inclusion criteria: * primary uterine malignancies. exclusion criteria: * metastatic malignancies to uterine corpus
nasopharyngeal 24 hour ph monitoring in health adult volunteers

Conditions: Gastroesophageal Reflux Disease

Summary: involves a 24-hour ph probe study using the dx-ph measurement system on patients who do not have symptoms of laryngopharyngeal reflux or gastroesophageal reflux disease to establish normal values for the dx-ph measurement system.

the specific aim of this study is to establish the normal range of values in an adult population with no symptoms of laryngopharyngeal reflux disease or gastroesophageal reflux disease using the dx-ph measurement system.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * no symptoms of laryngopharyngeal reflux or gastroesophageal reflux disease * score less than 10 on reflux symptom index exclusion criteria: * age less than 18 * known lidocaine allergy * history of heartburn, regurgitation, chronic cough, voice changes, globus pharyngeus, excessive throat clearing, or swallowing problems * score 10 or greater on reflux symptom index * current or past antacid use or other antireflux therapy * history of antireflux surgery * pregnancy * current anticoagulation therapy (warfarin, heparin, aspirin, clopidogrel bisulfate) * special/vulnerable populations (children, mentally handicapped, pregnant women, fetuses, prisoners, cognitive impairment, life-threatening disease, social or economic disadvantage)

Keywords: gerd laryngopharyngeal reflux disease
structured online contraceptive counseling (lowe trial) at emergency contraception (ec) pharmacy provision lowe+ec=lowec

Conditions: Contraception

Summary: to increase sexual and reproductive health and rights through the improvement of contraceptive counseling and easy access to service and, thus, women's use of effective contraceptives after purchase of an emergency contraceptive pill (ecp).

this pragmatic cluster randomised cross-over controlled trial aims to determine whether the composite intervention of online contraceptive counseling at the time of a pharmacy provision of emergency contraceptive pill (ecp), plus an invitation to a sexual and reproductive health clinic, will result in increased use of subsequent effective contraception (hormonal or intrauterine) compared with standard care. the study will be conducted at approximately 30 pharmacies in the stockholm region. clients who will buy an ecp (without prescription) at one of these pharmacies will be invited by posters and pharmacy personnel to participate in the study. by scanning a quick response (qr) code they will receive more information about the study. eligible women who choose to participate in the study and give their consent will be allocated to intervention or control group depending on the visited pharmacy's allocation. participants at the intervention pharmacies will receive an intervention package with online structured contraceptive counseling followed by an online invitation to a clinic for contraceptive provision. while participants at the control pharmacies will purchase the ecp without any further guidance. the order in which the pharmacies will provide the intervention or control will be randomly assigned at a ratio 1:1 by an independent statistician. the recruitment will halter for an intervening period of at least two weeks when the pharmacies switch to the new group depending on their first allocation (cross-over). an online baseline questionnaire and follow-up questionnaires will be collected at 1 and 12 months following the ecp provision for participants both from intervention and control pharmacies. the randomized controlled trial will be conducted together with a process evaluation.

Eligibility criteria:
inclusion criteria: * women \>/=15 years visiting a pharmacy to buy ecp for her own use * has a smartphone with an electronic identification and ability to scan a qr code * ability to read swedish or english * willing and able to provide informed consent * willing to participate in the follow-up exclusion criteria: \* ongoing pregnancy

Keywords: ehealth emergency contraception over-the-counter
physical activity, body composition, and prevalent asthma

Conditions: Asthma; Lung Diseases

Summary: to investigate the relationship of childhood lifestyle and physical characteristics to prevalent asthma.

background: morbidity and mortality from pediatric asthma have been increasing in developed countries over the past three decades, making asthma the most common chronic disease of children. a joint session at the american thoracic society meeting in may 2000 was titled "childhood asthma: is change in lifestyle the key"? during this session, the hypothesis was advanced that a lack of physical exercise and higher levels of childhood obesity may be contributing to an increased incidence of asthma among united states children. design narrative: data from physician diagnosed pediatric asthma were assessed for relationships with the potential risk factors body mass index, percent fat and lean tissue, obesity, and physical activity. the data pertained to a large population-based multi-ethnic cohort of school children (n=826) from the detroit area for whom, using dual-energy x-ray absorptiometry, precise measurements of whole body bone mass, and soft tissue composition were collected along with height and weight measurements in 1992-1993, when the children were nine years old. detailed data on physical activity, collected with consultation with an exercise physiologist, and prevalent asthma diagnosis and symptoms, collected under the direction of a respiratory disease/pediatric epidemiologist and a pediatric allergist, were obtained at the same time. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record

Eligibility criteria:
no eligibility criteria
stumbl score as a risk stratification tool for management of blunt chest trauma patients

Conditions: Blunt Injury of Thorax

Summary: the aim of this study is to assess validity of the stumbl score in egypt for complications of blunt chest trauma without multi-trauma and immediate life-threatening injuries and identify patients at risk of in- hospital mortality or icu admission and predict survival in both assiut \& suez canal university hospitals.

the stumbl score (study of the management of blunt chest wall trauma) (also referred to as the battle score) is a clinical prediction model that was developed and externally validated in 2014 in the uk . the purpose of the model is to assist in the clinical decision-making of patients with blunt chest wall trauma (excluding those with life-threatening injuries) in the emergency department (ed), through the calculation of a percentage risk of complications which in turn, provides a recommended discharge disposition. the stumbl score includes five predictors: age at attendance, number of rib fractures, chronic lung disease, use of pre-injury anticoagulants and oxygen saturation (spo2). this is the first score to introduce clinical variables, specifically chronic lung disease and anticoagulation, in contrast to other scores which have used anatomical variables and age alone. a huge benefit of the stumbl score is that these variables are all routinely measured in the ed. whilst other scores exist, the stumbl score is the only externally validated model with excellent predictive capabilities, that can be used for adult patients of all ages with blunt chest trauma presenting to the ed, not just a specific age group or severity of injury. collected data will be analyzed and tabulated by using appropriate statistical methods. statistical analysis will be performed by the spss statistical software computer program version 20 (statistical package for social science), medcalc v.11.6.and open epi v.3.01. data will be described using mean ± standard deviation (sd) and frequencies according if they are quantitative or qualitative respectively. parametric tests will be used in the current study if data proved to be normally distributed. for all statistical tests, a p value less than 0.05 will be taken to indicate a significant difference.

Eligibility criteria:
inclusion criteria: * the present study will be conducted on patients of blunt chest trauma of both genders "without intently selected certain gender" and had 18 years old or more. exclusion criteria: * patients \<18 years of age * patients with life threatening conditions

Keywords: blunt chest trauma stumbl score
tadalafil as adjuvant therapy for dmd

Conditions: Duchenne Muscular Dystrophy

Summary: this project will assess the vascular responsiveness in leg muscles of boys with duchenne muscular dystrophy (dmd) to one single dose of tadalafil, a common vasodilator drug, using non-invasive techniques (mri or doppler ultrasound) and exercise testing. these findings will provide proof of concept for a subsequent intervention study to demonstrate efficacy of longer-term tadalafil to counter sympathetic vasoconstriction and slow disease progression in dmd. it will also inform whether a group of patients do not respond to the drug.

this project will target up to 25 ambulatory boys with dmd aged 7-13 years. because the vascular impact of tadalafil is immediate, we will confirm that the drug target is valid target in lower extremities by assessing the change in post-exercise microvascular perfusion using blood oxygen level-dependent (bold) mri or change in post-exercise hyperemia using doppler ultrasonography. we will also assess the functional impact of the drug through exercise testing. patients will be randomized to undergo the above-mentioned assessments with or without the study drug on two separate visits. time function tests, mri-based fat fraction and inflammation measurements will also be obtained in all patients, thus characterizing disease severity and provide a sampling of information on whether a subset of patients do not respond to the drug. this information may be used to inform future trials as to the appropriate target population for pde5i as well as account for potential failures in a previously published phase 3 clinical trial.

Eligibility criteria:
inclusion criteria: * diagnosis of dmd confirmed by 1) clinical history with features before the age of five, 2) physical examination, 3) elevated serum creatine kinase level and 4) absence of dystrophin expression, as determined by immunostaining or western blot (\<2%) and/or dna confirmation of dystrophin mutation. * minimum entry age of 7.0 years * ambulatory exclusion criteria: * older than 13.0 years of age * contraindication to an mr examination (e.g. aneurysm clip, severe claustrophobia, magnetic implants) * presence of unstable medical problems * presence of a secondary condition that impacts muscle function or muscle metabolism (e.g. myasthenia gravis, endocrine disorder, mitochondrial disease) * contraindications to tadalafil (use of nitrates, alpha-adrenergic blockers, other pde5a inhibitors)

Keywords: therapy treatment strategy vasodilator exercise
assessing possible additive effects of tdcs and mirror therapy treatments for phantom pain

Conditions: Phantom Limb Pain

Summary: in this study we will examine assess if treatment with transcranial direct current stimulation (tdcs) improve the analgesic effects of mirror therapy for patients with phantom pain of lower extremity. the study will include 3 arms: only mirror therapy, mirror therapy + sham tdcs, and mirror therapy + active tdcs.

phantom pain following amputation is difficult to treat, resulting in many patients who suffer. one of the mechanisms suspected to contribute to phantom pain is abnormal plasticity and reorganization of the cortex. mirror therapy is a behavioral technique that proven useful for the treatment of phantom pain, yet the analgesic effects are unfortunately moderate and not long lasting. the assumed underlying mechanism of mirror therapy treatment is the induction of neuronal plasticity in the opposite direction than the abnormal reorganization of the cortex (due to the amputation), and by that relive pain. tdcs is a non-invasive technique that allow the administration of low currents directly to the scalp. the currents affect the cortex, and result in changes to the membrane potential of neurons in the stimulated area. this in turn affects the tendency of those neurons to generate action potentials. it was hypothesize that combination of mirror therapy and tdcs treatment could result in additive effects. according to this hypothesis, the effects of the mirror therapy could be enhanced by the tdcs treatment. the aim of the current study is to investigate this hypothesis.

Eligibility criteria:
inclusion criteria: 1. age 18 or older 2. underwent unilateral lower limb amputation in the past 3 months. a 3. reported average phantom pain of 4 or more in the past week. 4. no change in other medications 1 week prior to enrollment, not including sos. 5. able understand the purpose of the study and to provide informed consent. exclusion criteria: 1. ferromagnetic metal in the head or neck. 1. epilepsy or prior seizures within the last 1 year. 2. suffering from severe depression 3. history of unexplained fainting or loss of consciousness
the effect of a respiratory muscle warm-up prior to exercise in patients with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is to investigate the effects of performing a breathing muscle warm up before exercise in patients who have chronic obstructive pulmonary disease (copd). the main aim is to see whether performing a breathing muscle warm up can improve distance walked in a 6 minute walk test and also decrease perceptions of effort and breathlessness.

the study will follow a counter-balanced repeated measures design involving six visits to the exercise laboratory. following pre-screening and familiarisation (visits 1 and 2), participants will perform inspiratory warm up, expiratory warm up, combination warm up and control trials (visits 3 - 6) in a counter-balanced order separated by at least 48 hours between trials. the four separate sessions will contain: lung function measurements assessed by performing breathing manoeuvres through a mouthpiece (spirometery or body plethysmography) before performing a breathing muscle warm up by breathing against a resistance through a small handheld device (powerlung). participants will then be asked perform a second set of lung function measurements and will then be asked to perform a 6 minute walk test wearing a face mask and a portable device (gas analysis), a small device clipped to a finger (pulse oximeter) and wearing a heart rate monitor. during this 6 minute walk test participants will also be asked to rate their perceived effort and level of breathlessness at 60m intervals. following the test there will be a period of seated rest wearing the face mask and portable device for up to 20 minutes with one more set of lung function measurements.

Eligibility criteria:
inclusion criteria: * a clinical diagnosis of copd * aged between 35 and 90 years * able to fluently read and speak english * willing and able to sign informed consent * be able to comply with the procedures outlined for the study exclusion criteria: * cardiac disease (including arrhythmias) * a medicinal requirement for rate limiting calcium antagonists or beta blockers * cerebrovascular disease * peripheral vascular disease * requirement for supplemental oxygen therapy * co2 (carbon dioxide) retention * malignancy * orthopaedic or neurological conditions effecting the ability to exercise * clinically apparent heart failure * renal, hepatic or inflammatory disease * instability of copd * any other reason leading to the inability to complete the requirements of the study. additionally: if participants have a resting hr above 120beats.min-1, systolic blood pressure above 180mm hg or diastolic blood pressure above 100mm hg prior to the 6 minute walk test they will not be able to commence the test.

Keywords: copd respiratory muscle warm up
study of cryotherapy for renal tumors

Conditions: Renal Tumors

Summary: the purpose of this study is to study the change of tumor size and serum cytokine in the patients who received cryotherapy for the renal tumors.


Eligibility criteria:
inclusion criteria: * the patients who have renal tumor less than 7 cm and receive cryotherapy exclusion criteria: * the tumor size is larger than 7 cm * the patients do not approve the surgery

Keywords: renal tumor cryotherapy cytokine
interleukin-10 promoter-1082a/g polymorphism and idiopathic recurrent miscarriage risk

Conditions: Abortion, Spontaneous

Summary: this study aimed to assess the correlation between the interleukin-10 (il-10)-1082a/g polymorphism and idiopathic recurrent miscarriage (irm) of chinese han. a total of 100 women with irm and 100 control women with a successful pregnancy will be included in this study. then genotyping will be performed.

as a common occurrence in early pregnancy, irm has been associated with multiple causes, among which the disorders of immune homeostasis between the fetus and the maternal immune system, maintained by cytokines from the complex regulatory network, are considered one of the potential etiological factors underlying irm. the il-10 polymorphism -1082a/g (rs1800896), which is located in the promoter region of the il-10 gene, was reported to be implicated in the abnormal expression of il-10 in irm by some studies. however, no such reports about the association between il-10 polymorphism -1082a/g and irm risk in chinese han.

Eligibility criteria:
inclusion criteria: 1. women with more than three consecutive unexplained pregnancy losses before the 20th week; 2. chinese han population; 3. patients who signed informed consent. exclusion criteria: 1. patients who had other high-risk factors which might relate with recurrent miscarriage, including: (1) parental karyotype abnormalities: significant rearrangements (e.g. balanced translocations and mosaics) were considered abnormal. if either the patient (or her partner) had an abnormal karyotype, it was considered a parental karyotypic abnormality; (2) genital tract abnormalities: any congenital anatomical deformation of the genital tract was considered abnormal; intrauterine adhesions, endometriosis and hydrosalpinx were also considered abnormal; (3) alloimmune disorder; (4) endocrine abnormalities: prolactin (prl) level \>25 ng/ml, testosterone level \>2.6 nmol/l, thyroid-stimulating hormone level \ 4.5 mu/l, free thyroxine (ft4) level \ 29.6 nmol/l and free triiodothyronine (ft3) level \ 7.39 nmol/l. glucose level \> 126mg/dl; (5) autoimmune disorders: any positive results of anti-cardiolipin antibodies (aca-igg/igm/iga), anti-nuclear antibodies (ana-igg), anti-endometrium antibodies (aea-igm), anti-ovary antibodies (aoa-igm), anti-sperm antibodies (asa-igm), antithyroidin(tg-ab), anti-thyroid peroxidase antibody(tpo-ab) and/or anti-chorionic gonadotropin hormone antibody; (6) hypercoagulation state: d-dimer levels \>260 ng/ml, fibrin degradation products (fdp) levels \>5 mg/l or anti-beta 2-glycoprotein i (anti-beta 2-gp1) levels \>15 u/ml; (7) negative rh blood groups; (8) abnormal semen routine results of patients husband. 2. patients with serious diseases; 3. patients with administration of contraceptive pills; 4. patients participated in other randomized clinical research; 5. patients could not be followed-up of a long time or had poor compliance; 6. patients with other factors that would affect the study result.

Keywords: interleukin-10 polymorphism, single nucleotide
can ultrasound be used to verify cvc position and to exclude pneumothorax?

Conditions: Catheterization, Central Venous

Summary: the purpose of this study is to determine if emergency room physicians can use bedside ultrasound to quickly determine the proper placement of a central venous catheter and to evaluate for complications such as a punctured lung.

central venous catheterization (cvc) of the subclavian or internal jugular veins is a common procedure performed in the emergency department (ed). this procedure is followed by complications in 0.3 to 12% of cases. pneumothorax (ptx) and catheter-tip misplacement can occur. the diagnosis of these complications requires a chest radiograph (cxr). in certain cases, cxr may be time-consuming, requiring more than 30 minutes. this could be harmful in the case of critically ill patients. moreover, several investigators have questioned the need of routine post-procedural cxr in the absence of clinical complications. recent data has shown that ultrasound can accurately detect ptx in critically ill patients. furthermore, bedside ultrasound is an easy technique to investigate the subclavian and internal jugular veins, and can improve the success rate of catheter insertion. ultrasound also allows visualization of central venous catheters in vivo. ultrasound has been reported as a tool to detect catheterization complications and misplacement when performed by icu physicians, but has never been studied in the ed. this method could be valuable in hemodynamically unstable patients, who quickly need a cvc for the measurement of central venous pressure, immediate fluid resuscitation, and infusion of vasoactive medications. similarly, bedside ultrasound examination could quickly confirm ptx and allow immediate chest tube insertion in case of respiratory distress after catheter insertion. we hypothesize that bedside ultrasound examination performed by ed physicians could accurately detect placement of the cvc and the presence or absence of a ptx after catheterization of the jugular and subclavian veins.

Eligibility criteria:
inclusion criteria: * male or female 18 years or older * signed consent * in need of subclavian or internal jugular central line placement exclusion criteria: * any subject who refuses or whose family refuses to sign consent * any subject in whose immediate transfer from the care of the ed to another location is mandated by clinical presentation * any subject under the age of 18 * any subject being evaluated for chest trauma.