Kornimate/medical-research-clean huggingface dataset:
self-collection and human papillomavirus (hpv) testing in unscreened women: a feasibility study in brazil

Conditions: Cervical Cancer

Summary: our long-term goal is to decrease cervical cancer incidence and mortality among women in low- and middle-income countries (lmics) by using the most efficacious and acceptable screening method, particularly among women who do not come to the clinic for their regular pap testing. the purpose of this feasibility study is to compare three cervical cancer screening modalities (self-collection and hpv testing, pap testing at the public health clinic, and choice between self-collection and hpv testing and pap testing) among women who have not undergone cervical cancer screening within the past four years using a theory-based, culturally relevant intervention implemented by community health workers (chws) via door-to-door visits. three basic health units (bhus) within the public health system will be randomly assigned to one of the three screening modalities/conditions (self-collection and hpv testing, pap testing at the local public health clinic, and choice between self-collection and hpv testing and pap testing). chws will invite women who report not having been screened for cervical cancer in the past four years to participate in the study, and deliver a brief educational/behavioral session on cervical cancer and screening using a door-to-door approach under of one of the three conditions. the primary outcome will be adherence to cervical cancer screening. we hypothesize that (1) women in the "choice" and "self-collection" groups will be more likely to engage in cervical cancer screening and display higher satisfaction with their screening than women assigned to the "pap" with women assigned to the "choice" group having the highest adherence of the three groups; and (2) within the "choice" group, more women will choose and complete self-collection than pap test.


Eligibility criteria:
inclusion criteria: * no personal history of cervical cancer * not have engaged in cervical cancer screening for the past 4 years exclusion criteria: * none

Keywords: self-collection for hpv testing
evaluation of a food supplement on sleep quality

Conditions: Insomnia

Summary: the purpose of this study is to evaluate the efficacy on sleep quality of a food supplement.


Eligibility criteria:
inclusion criteria: * healthy volunteer aged between 25 to 65 years * patient diagnosed for primary insomnia (threshold for inclusion: 10 on the isi scale) * healthy volunteer without diurnal sleep (total score for inclusion must be less than 10 on the epworth scale) * patient affiliated to the french social security * patient who gave written informed consent exclusion criteria: * secondary insomnia * history of severe psychiatric disorder, assessed by the mini test * resistance to hypnotic drugs * anxiety, depression, suicide, detected by the beck depression inventory * acute pathology during the precedent three years * breast feeding and pregnancy women * non compliant volunteer * hypersensibility to treatment composant

Keywords: sleep quality food supplement randomized controlled trial actigraphy leeds volunteers presenting moderate primary insomnia
duchenne muscular dystrophy < 18y in norway: genotype/phenotype, growth, puberty, bone health and quality of life.

Conditions: Duchenne Muscular Dystrophy

Summary: the study will give a consent based epidemiological overview of norwegian patients with duchenne muscular dystrophy younger than 18 years of age. genotype of the population will be described. longitudinal development of growth, bone health, and , when applicable, puberty over a two year period will be studied. questionnaires regarding quality of life will also be an important part of the study.

the participants who are not regularly seen at our regional hospital, are recruited via their local neuropediatrician. patients who do not come to our region hospital will be seen at their local hospital.each participant will be seen up to three times with one year between each visit. the visits include clinical examination, dxa scan, x-ray for bone age, and blood tests including several parameters related to bone health, growth and puberty. standardized questionnaires regarding quality of life (patients and parents) will be used, and certain questions regarding the importance of achieving normal height and puberty will be added. additional anamnestic data will be retrieved from the patients' medical records.

Eligibility criteria:
inclusion criteria: * diagnosis of duchenne muscular dystrophy * age under 18 years * residing in norway exclusion criteria: -

Keywords: genotype/phenotype correlations growth bone health puberty quality of life
assessement of viral shedding duration after a respiratory tract infection in oncology and hematology patients

Conditions: Respiratory Tract Viral Infection

Summary: the purpose of this study is to assess the duration of the viral shedding in hematology and oncology patients after a respiratory tract viral infection. this duration has not been much studied in that population whereas it is probably longer than that in immunocompetent patients. thereby it may be a source of transmission amongst these immunocompromised patients.

the development of multiplex polymerase chain reaction (pcr) tests has greatly improved the diagnosis of respiratory tract viral infections by increasing its sensitivity and the diversity of viral species detected. however, there are few data concerning respiratory tract viral infections amongst hematology and oncology patients. especially, the duration of viral shedding following an infection has not been much studied whereas it is a source of inter-individual transmission between immunocompromised patients who are more likely to develop severe disease. studies conducted so far concerned mainly hematology patients. they have shown that viral carriage could last up to one month and a half in some patients with hematological malignancy. the aim of this study is to determine the duration of the viral shedding in patients from hematology and oncology units after a respiratory tract viral infection for the ten main viruses involved in order to better manage these infections and to better prevent their transmission.

Eligibility criteria:
inclusion criteria: * patient with solid organ cancer or haematological malignancy with or without chemotherapy * having symptoms of upper and/or lower respiratory tract infection * virus detected by pcr in nasal sample * signature of consent exclusion criteria: * hematological stem cell and solid organ recipients * no health insurance * protected people

Keywords: respiratory tract infections virus shedding cancer immunocompromised host
anlotinib treatment in steroid depenent/refractory cgvhd

Conditions: Chronic Graft-versus-host-disease

Summary: this is a single center, single arm, prospective, phase ii clinical study. the main purpose of this study is to evaluate the efficacy and safety of anlotinib in the treatment of steroid dependent/refractory chronic graft-versus-host disease (cgvhd) after allogeneic peripheral blood stem cell transplantation (allo hsct).

anlotinib 8mg qd po for 6months if no progression in 4weeks or reach pr in 3months

Eligibility criteria:
inclusion criteria: 1. participants must be diagnosed as hematopoiesis disorders and receiving hematopoietic stem cells transplantation. 2. steroid dependent or refractory classic chronic gvhd disease defined as modified national institutes of health criteria(2014) below at any time post-hematopoietic cell transplant(post-hct) 1. dependent disease, defined as, when glucocorticoid (prednisolone doses greater than or equal to(\<=) 0.25mg/kg/day or \<=0.5mg/kg every other day(prednisolone doses) due to recurrence or progression of cgvhd manifestations, it is considered as steroid-dependent disease if the lowest tapering dose of the second occasion is equal or higher than the lowest tapering dose of the first occasion 2. refractory disease, defined as, when cgvhd manifestations progress despite the use of a regime containing glucocorticoid (prednisolone at \>=1mg/kg/day for at least 1 week) or persist without improvement despite continued treatment with glucocorticoid (prednisolone at \>=0.5mg/kg/day or 1mg/kg every other day) for at least 4 weeks. 3. participants must be receiving baseline systemic glucocorticoid therpy for cgvhd at study entry. the dose of steroids must be stable for 14 days prior to starting anlotinib. 4. at the time of trial enrollment, participants may be receiving other immunosuppressive therapies in addition to glucocorticoids. immunosuppressant doses must be stable for 14 days prior to starting anlotinib. 5. neutrophil≥1.5×109/l，platelet≥50×109/l 6. karnofsky or lansky performance status\>=60 7. participants should sign the agreement. exclusion criteria: 1. known or suspected active acute gvhd. 2. current treatment with a tyrosine kinase inhibitor, purin analogs or other cancer chemotherapy in the 4weeks prior to starting study drug. 3. concomitant use of warfarin or other vitamin k antogonists. 4. known bleeding disorders or hemophilia. 5. known history of human immunodeficiency virus or active with hepatitis c. virus or hepatitis b virus. 6. uncontrolled infections not responsive to antibiotics, antiviral medicines, or antifungal medicine or recent infection requiring systemic treatment .
a study to evaluate the efficacy and safety of ad-221 and ad-221a

Conditions: Primary Hypercholesterolemia

Summary: the purpose of this study is to evaluate the efficacy and safety of ad-221 and ad-221a

the purpose of this study is to evaluate the efficacy and safety of ad-221 and ad-221a in patients with primary hypercholesterolemia

Eligibility criteria:
inclusion criteria: * signed informed consent * subjects with primary hypercholesterolemia exclusion criteria: * patient with secondary dyslipidemia * other exclusions applied
the effect of kinesio taping in pediatric surgery

Conditions: Appendicitis; Surgery; Pain, Acute

Summary: this study was planned to determine the effect of kinesio taping (kt) applied to the abdominal area after surgery on pain and gas output in children aged 6-12 years who had open appendicitis surgery.

it is stated that kinesio taping, alone or in combination, is an alternative application for the pain management of various disease and symptom processes. these sources state that kinesion relieves pain and makes movement easier. when the literature was examined, no study could be found examining the effectiveness of kinesio tape application in pain management and flatulence in the post-operative period in children who had appendicitis surgery. for this reason, this study aimed to examine the effect of kinesio taping applied to the abdominal area on pain and gas output after appendicitis surgery in children between the ages of 6-12.

Eligibility criteria:
inclusion criteria: * open appendicitis surgery was performed, * are between the ages of 6-12, * conscious, literate and without hearing or speech problems, * children who do not have a mental disorder and agree to participate in the research will be included. exclusion criteria: * exclusion criteria: * do not apply analgesic treatment other than routine application. * patients who develop complications during the operation will be excluded from the study. * those with acute appendicitis or angenesis appendicitis
pharmacokinetics of efavirenz in hiv-1 infected subjects with hepatic impairment

Conditions: HIV Infections; Hepatic Impairment

Summary: the purpose of the study was to assess the steady-state pharmacokinetics (pk) of efavirenz (efv) in human immunodeficiency virus type 1 (hiv-1) infected subjects on stable antiretroviral regimens containing efv, and having selected degrees of hepatic impairment or normal hepatic function.


Eligibility criteria:
inclusion criteria: * hiv-1 infection with or without hepatitis b or c infection * stable antiretroviral regimen containing efavirenz and nucleoside/nucleotide reverse transcriptase inhibitors (nrti) for at least 1 month * mild, moderate or severe hepatic impairment with hepatic cirrhosis exclusion criteria: * acute flare of hepatitis * positive pregnancy test for a female * significant acute medical illness in past 2 months * use of agents known to significantly affect liver metabolism * change in medications to treat a chronic disease in the past 2 months
volume outcome relationships and effects

Conditions: Esophageal Cancer

Summary: this is a retrospective analysis to assess if high-volume hospital facilities experience greater or lesser rates of incidence in patients with esophageal cancer than low-volume facilities.

this is a retrospective analysis to assess if high-volume hospital facilities experience greater or lesser rates of incidence in patients with esophageal cancer than low-volume facilities. the relationship between volume and outcomes has been proven in pancreatic cancer. similar to pancreatic cancer, esophageal cancer historically has a bad prognosis. esophageal cancer is typically asymptomatic, resulting in an advanced stage at the time of diagnosis. additionally, it also has a significantly high morbidity and mortality. therefore, it is crucial to determine volume-outcome relationships in esophageal cancer. this study aims to elucidate what these findings may entail by evaluating the impact that the volume-outcome relationship has on treatment assessment in esophageal cancer patients. the purpose of the study is to evaluate the outcomes of esophageal cancer resection in patients in high volume (more than 5 esophagectomy performed per year) and low volume (less than 5 esophagectomy performed per year) hospital facilities. furthermore, this paper will assess the outcomes of neoadjuvant and adjuvant therapy in esophageal cancer.

Eligibility criteria:
inclusion criteria: * esophageal cancer exclusion criteria: * no esophageal cancer
an online intervention to address barriers to ibd medication adherence

Conditions: Inflammatory Bowel Disease (IBD)

Summary: background inflammatory bowel disease (ibd) is a group of lifelong and relapsing inflammatory conditions that usually affect the colon and the small intestine. between 30 to 45% of patients with ibd do not take their treatment as prescribed by their health care team (jackson, clatworthy et al. 2010). the perceptions and practicalities approach (papa) provides a theoretical framework to develop adherence interventions that are patient-centred (horne, 2001). unintentional non-adherence occurs when the patient wants to take the medication but there are barriers beyond their control, such as not understanding the instructions (practical barriers). intentional non-adherence is the result of the beliefs affecting the patient's motivation to continue with treatment (perceptual barriers). aims 1. to develop an internet-based intervention to address perceptual and practical barriers to adherence to medicine for ibd. 2. to determine whether the intervention is effective based on change in both types of barriers. plan of investigation the inclusion criteria are: age 18 or over; diagnosis of ibd; currently prescribed azathioprine, mesalazine, and/or adalimumab. 240 participants identified via crohn's and colitis uk and through two nhs ibd clinics will take part in the study. an online pilot randomised controlled trial will allocate the participants either to a cognitive behavioural therapy (cbt) based online intervention or treatment as usual group. on first visiting the website, participants will be screened for eligibility and asked for consent before answering the questionnaires. the website will assign intervention modules to be completed based on an individual's profile. outcomes: beliefs about medicines scores will be measured at baseline, 1 month and 3 month follow-ups. potential impact a cbt based online intervention tailored to personal needs and concerns may benefit a large number of patients with low costs for the national healthcare services. a website can be accessed at a time and place convenient to the patient.


Eligibility criteria:
inclusion criteria: * age 18 or over. * diagnosis of ibd (crohn's disease or ulcerative colitis or indeterminate colitis). * currently prescribed one or more of the following medications for ibd: azathioprine, mesalazine, and adalimumab. exclusion criteria: * we will exclude people who are for any reason unable to make an informed decision about taking part and people who do not wish to complete follow-up questionnaires. * people who declare that they do not understand written english. this is a pilot feasibility study that aims to assess the effectiveness and acceptability of an online cbt based intervention in english.

Keywords: inflammatory bowel disease (ibd) crohn's disease ulcerative colitis cognitive behavioural therapy (cbt) medication adherence
structural and functional grey and white matter changes in patients with pain disorders

Conditions: Central Post-stroke Pain

Summary: the goal of this observational study is to examine the association between exact lesion location and presence of thalamic cpsp (central post-stroke pain) in a larger number of patients after thalamic stroke.

the researchers will explore how the brain areas and mechanisms of brain plasticity are involved in the generation of thalamic cpsp, compared to other pain disorders, using structural and functional magnetic resonance imaging (mri) at 3 tesla. the functional magnetic resonance imaging (fmri) will be also used to assess the cerebral processing of heat/cold stimuli in patients with thalamic pain compared to thalamic stroke patients without pain, to patients with migraine (other central pain disorder) and to normal controls. in addition the researchers want to assess the somatosensory profile of thalamic pain patients and compare it with thalamic stroke patients without pain, patients with migraine (pain control) and normal controls.

Eligibility criteria:
inclusion criteria: 1. patients with thalamic central post-stroke pain (cpsp) : patients fulfilling all of the following inclusion criteria are eligible for the study: * informed consent as documented by signature (appendix informed consent form) * history of thalamic stroke (infarction or bleed) * diagnosis of definite central-post stroke pain (according to the criteria proposed by klit et al, 2009) * no other chronic pain condition * age: ≥18 years old 2. patients with thalamic stroke without cpsp: patients fulfilling all of the following inclusion criteria are eligible for the study: * informed consent as documented by signature (appendix informed consent form) * history of thalamic stroke (infarction or bleed), at least 2 years ago * no chronic pain condition (neither cpsp or other pain condition) * age ≥18 years old 3. patients with migraine (other pain condition): patients fulfilling all of the following inclusion criteria are eligible for the study: * informed consent as documented by signature (appendix informed consent form) * history of highly frequent (≥8 monthly migraine days) or chronic migraine (≥15 monthly migraine days). * no history of stroke * age ≥18 years old 4. healthy controls: participants fulfilling all of the following inclusion criteria are eligible for the study: * informed consent as documented by signature (appendix informed consent form) * no history of stroke * no chronic pain condition * age: ≥18 years old exclusion criteria: * history of severe neurological, internistic or psychiatric disease * mri related exclusion criteria: * paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the brain) * pacemaker * claustrophobia * pregnancy

Keywords: thalamic pain thalamic stroke chronic pain sensory abnormalities pain disorder migraine
cost- effectiveness and quality of life assessment in bipolar disorder depressive episode

Conditions: Bipolar Disorder

Summary: to evaluate the effectiveness of an algorithm for bipolar disorder depressive episodes (bdd) using medications available in the brazilian public healthcare system (sus). quality of life assessment of these patients was also employed. a randomized pragmatic trial was conducted. an algorithm was developed for the treatment of episodes of bipolar disorder depression episodes.

the study design was that of a pragmatic randomized clinical trial to evaluate the effectiveness of treatments for mood disorders in a public healthcare context in the city of porto alegre, in southern brazil. the algorithm was originally developed for the treatment of bipolar disorder depressive episodes by a delphi panel of experts from psychiatric associations in brazil. all subjects provided an informed consent form, in writing, in order to participate in the study protocol, which was approved by the institutional ethics committee. procedures and measurements of the study: the subjects under evaluation were selected and they followed the stages defined by the treatment protocol: 1. sample selection by being referred from the primary healthcare clinics in the municipality; 2. informative talk about mood disorders and the research, with the informed consent forms being provided to the subjects; 3. screening for unipolar depression episodes with the use of the patient health questionnaire (phq-9), and hypomanic symptoms checklist brazilian version (hcl -32-bv); 4. diagnostic evaluation through the mini international neuropsychiatric interview (mini) and clinical interview for individuals with positive results in the screening instruments; 5. baseline and demographic assessments using standardized semi-structured interviews in the first and second visits; 6. in each clinic visit, the severity of the symptoms were evealuated using the clinical global impression scale (cgi), hamilton rating scale for depression (hrsd), and young manic rating scale (ymrs); 7. biweekly follow-up, changed to monthly after stabilization - with a maximum follow-up period of 52 weeks.

Eligibility criteria:
inclusion criteria: 1. ages between 18 and 65; 2. bd current acute mixed episode; 3. total capacity to understand and respond to self-applied instruments; 4. the presence of symptoms in the last 30 days; 5. abstinence for at least 30 days for drug addicts. exclusion criteria: 1. presence of organic brain syndrome (obs); 2. pregnancy or lactation; 3. criteria for psychiatric hospitalization. -

Keywords: cost effectiveness bipolar disorder depressive episodes quality of life