Kornimate/medical-research-clean huggingface dataset:
glucose metabolism in different pcos phenotypes

Conditions: Polycystic Ovary Syndrome; Glucose Intolerance; Liver Fat; Glucose Metabolism Disorders

Summary: in the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (pcos) and in healthy control subjects.

in detail an oral glucose tolerance test (ogtt) was conducted in women with the pcos defined by the rotterdam and the nih-criteria, as well as in healthy control subjects. in addition 1h-magnetic resonance spectroscopy and imaging was used for the assessment of the ectopic lipid content in the liver, heart and skeletal muscle. the aim of the present study was to compare the glucose metabolism and the ectopic lipid conent in the liver, heart and muscle between women with the pcos defined by the nih-criteria, rotterdam-criteria and healthy control subjects.

Eligibility criteria:
inclusion criteria: * women with the polycystic ovary syndrome defined according to the rotterdam and the nih-criteria * healthy control subjects exclusion criteria: * bmi\>=40kg/m² * diagnosis of diabetes in the pcos-group * diagnosis of prediabetes or diabetes in the control group
t2 and septicyte rapid duration project

Conditions: Bacteremia

Summary: infection with bacteria and other germs in the blood can be deadly. how long germs stay in the blood is important for two reasons. the first is that if they stay in the blood for many days it is a sign that antibiotics may need to be changed. the second is that if they stay in the blood for only a short time it may give doctors confidence to switch to tablets and consider early discharge from hospital. this study is evaluating the diagnostic and prognostic performance of two novel technologies when used to measure the duration of the bloodstream infection.

bloodstream infection is highly significant and is associated with mortality rates of between 10 and 25%. for some infection types (for example, staphylococcus aureus) a longer duration of bacteria being present in the blood is linked to higher mortality. with traditional microbiologic techniques, bloodstream infection with gram-negative bacteria is usually quite brief. however, new culture independent bacteraemia detection systems (such as t2 magnetic resonance assay) are more sensitive than traditional blood culture systems and may show that gram-negative bacteraemia is more prolonged in some patients than has previously been thought. this observational study will investigate the correlation between the duration of bloodstream infection by mean of traditional blood culture techniques with: 1. duration of the bloodstream infection by mean of the t2 magnetic resonance assay, a new culture independent bacteraemia detection system. 2. persistence of inflammation as measured by the septicyte rapid test, a host response assay able to differentiate infectious from sterile inflammation. the study will also correlate each measure of the duration of bacteraemia with microbiological and clinical outcomes.

Eligibility criteria:
inclusion criteria: * patients who have proven bloodstream infection with any t2-on panel pathogen (enterococcus faecium, s. aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, escherichia coli and candida spp.) exclusion criteria: * palliative care approach * failure to give written informed consent (by patient or their legal representative) * polymicrobial index blood culture

Keywords: bacteraemia gram-negative bacteremia bacterial infections t2 magnetic resonance assay septicyte rapid
comparison of erector spina plane block and thoracic epidural block

Conditions: Breast Neoplasms; Pain, Postoperative

Summary: the aim of this randomised controlled and double-blind study, is to compare the effects of erector spinae plane (esp) and thoracic epidural (tea) blocks on peri-operative hemodynamics and analgesia in patients undergoing unilateral mastectomies due to malignancy.

patients will be randomised into two groups as group e (those who received general anesthesia after the erector spina plan block) and group t (those who received general anesthesia after thoracic epidural block). after the block skin conductivity (galvanic skin response - gsr), body temperature changes, sympathetic and sensory block levels, peri-operative hemodynamic data, postoperative pain scores and analgesic consumption will be recorded.

Eligibility criteria:
inclusion criteria: * asa(american society of anesthesiologist) physical classification i-iii * patients undergoing unilateral mastectomies due to malignancy exclusion criteria: * active infection at the intervention site * history of coagulopathy or anticoagulant use (less time has passed before peripheral and central blocks) * major cardiac, pulmonary, renal and neurological diseases * autonomic neuropathy or use of drugs that affect autonomic function * patients with type 1 diabetes or insulin dependent type 2 diabetes over 10 years * allergic to local anesthetics; * patients who are uncooperative or have psychiatric problems * morbidly obese (body mass index \> 35 kg/m2)
hematopoietic stem cell transplantation from human leukocyte antigen (hla) compatible donor in ewing sarcomas and soft tissues sarcomas

Conditions: Ewing; Soft Tissue Sarcoma

Summary: this is a perspective multicentric study for the treatment of patients aged equal or less than 60 years and submitted to an allogeneic hematopoietic stem cell transplantation from an hla compatible related or unrelated donor because affected by resistent or refractory or relapsed after autologous stem cell transplantation ewing sarcoma or soft tissues sarcoma who did not benefit from conventional therapy.


Eligibility criteria:
inclusion criteria: * age 0-60 years. * performance status according to karnofsky score \> 70% * normal liver function * normal renal function * normal cardiac function * informed consent * availability of an hla compatible donor exclusion criteria: * absence of at least one of the inclusion criteria

Keywords: sarcoma allogeneic hemopoietic stem cell transplant
evaluate the efficacy and safety of m518101 in subjects with plaque psoriasis

Conditions: Psoriasis

Summary: this study is to evaluate the efficacy and safety of m518101 in subjects with plaque psoriasis


Eligibility criteria:
inclusion criteria: * who are able and willing to give signed informed consent * who are male or females aged 18 years or older with plaque psoriasis confirmed by the investigator. * who have up to 20% of body surface area (bsa) afflicted with plaques * who are neither pregnant nor breast-feeding, nor plan to become pregnant during the study. exclusion criteria: * who have a history of allergy to vitamin d3 derivative preparations or a history of relevant drug hypersensitivity. * who are pregnant or lactating. * who have any renal or hepatic insufficiency, or clinically significant cardiac, renal or hepatic disease. * who are not deemed eligible as determined by medical history, physical examination or clinical laboratory safety tests. * who have clinically relevant history or presence of any disease or surgical history other than psoriasis which is likely to affect the conduct of the study * whose serum calcium levels exceed the upper limit of reference range * who have used any investigational medicinal product and/or participated in any clinical study within 60 days of randomization. * who have been treated with systemic therapy within 30days of randomization. * who have treated with biologics within 5 half-lives of the biologics before the day of randomization * who have been treated with topical therapy within 14days before the day of randomization.
the acute effect of a theacrine-based supplement on mobilization of various stem cell populations.

Conditions: Stem Cells

Summary: the goal of the study is to determine the acute and short-term supplementation effect of a commercially available theacrine-containing supplement (nad3) on numbers of various circulating stem cell populations in older adults.

this is a double-blind, placebo-controlled crossover study with 12 participants randomized to receive either nad3® or a placebo for seven days. blood samples are collected after an overnight fast, before and after the seven-day supplementation period, as well as one and two hours after the final supplement/placebo dose. using flow cytometry, circulating stem cells, including lymphocytoid cd34+ stem cells (cd45dimcd34+), stem cells associated with vascular maintenance and repair (cd45dimcd34+cd309+), cd34+ stem cells linked to a progenitor phenotype (cd45dimcd34+cd309neg), circulating endothelial stem cells (cd45negcd31+cd309+), and mesenchymal stem cells (cd45negcd90+) are quantified.

Eligibility criteria:
inclusion criteria: * male or female * age 40-70 * bmi between 21-34.99 kg/m2 * vital signs with in normal range (heart rate 60-100 beats/minute, blood pressure (40-44 years - 125/83, 45-49 years- 127/84, 50-54 years -129/85, 55-59 years - 131/86, \>60 - 134/87), 36.4-37.4 degrees celsius * sedentary to lightly active (2 or fewer days per week of exercise) exclusion criteria: * female participants who are lactating, pregnant or planning to become pregnant during the study * history of use of illicit drugs or other substances of abuse within 12 months of the screening visit (to be determined at screening) * tobacco during the 90 days prior to screening * current use of medication/dietary supplements that claim to or have an effect on age-related processes, e.g. "anti-aging" supplements. participants must undergo a ≥7-day washout period of no supplementation to be eligible. * known allergy, intolerance or hypersensitivity to nad3 * self-reported active infection or illness of any kind * cognitively impaired and/or unable to give informed consent
observational trial tolerability and efficacy of resiquimod gel in patients treated for actinic keratosis.

Conditions: Actinic Keratosis

Summary: determine the recurrence rate of actinic keratosis (ak) lesions in patients with complete clinical clearance at the end of the previous trial sp848-ak-1101 at 6 and 12 months of follow-up.

efficacy evaluation: • primarily based on clinical inspection of the former 25 cm2 treatment area and count of the ak-lesions. safety evaluation: * evaluation of adverse events (aes) and serious adverse events (saes) * evaluation of newly occurred dermal adverse events (aes) and serious adverse events (saes) in the previous treatment area at 6 months and 12 months of follow-up (local tolerability). * follow-up of unresolved adverse and serious adverse events that occurred in the previous trial sp848-ak-1101. * follow-up of unresolved abnormal laboratory values that occurred in the previous trial sp848-ak-1101.

Eligibility criteria:
inclusion criteria: * signed informed consent. * participation in the previous clinical trial sp848-ak-1101. * patient with complete clinical clearance (i.e. no previously existing ak-lesion present) at the end of the trial sp848-ak-1101 or non-responder who withdrew from the trial prematurely. exclusion criteria: * evidence of unstable or uncontrolled clinically significant medical conditions as determined by the investigator (e.g., cardiovascular, immunological, hematologic, hepatic, neurologic, renal, endocrine, collagen-vascular, infectious, gastrointestinal abnormalities or diseases). * evidence of systemic cancer. * dermatological disease or condition in the former treatment or surrounding area that might impair trial assessments (e.g., rosacea, atopic dermatitis, eczema) as assessed by the investigator.
hospital-based cluster trial: magnetically controlled growing rods using distraction intervals

Conditions: Early-Onset Scoliosis Deformity of Spine

Summary: a hospital-based cluster stratified randomization control study will be conducted to investigate spinal growth in early onset scoliosis patients between 5 and 9 years of age. patients must have a major coronal curve measuring over 50 degrees and be undergoing magnetically controlled growing rod treatment. we will be studying 6-week lengthening intervals compared to 16-week lengthening intervals on spinal growth within 3 years.

the magnetically controlled growing rod (mcgr) system consists of growing rods similarly implanted as with traditional approaches, but with subsequent noninvasive distractions. the implanted growing rods are magnetically controlled and adjusted outside the body using an external remote controller (erc) following initial surgical insertion. no incision or anesthesia are used for rod lengthening procedures and they are performed by the surgeon in an outpatient or office setting. the purpose of this study is to determine the effect of a 6-week lengthening interval compared to a 16-week lengthening interval on spinal growth in early onset scoliosis patients between 5 and 9 years of age with a major coronal curve over 50 degrees undergoing mcgr treatment within 3 years.

Eligibility criteria:
inclusion criteria: * all patients with diagnosis of early onset scoliosis (scoliosis before age 10) * between 5 and 9 years of age (5.0 to 9.9 years) * major curve greater than 50 degrees at time of index surgery * dual-rod magnetically controlled growing rod implantation only * spine or rib-based constructs * pre-operative and intra-operative halo gravity traction is allowed exclusion criteria: * patients with previous spine surgery, including other growth friendly techniques * patients who cannot abide by the study requirements due to geographical or other similar constraints

Keywords: spinal deformity, early onset scoliosis
efficacy of computer controlled intraosseous anesthesia in pediatric dental patients

Conditions: Irreversible Pulpitis; Tooth Extraction

Summary: to evaluate the effectiveness of intra-osseous anesthesia using quicksleepr5 in pain elimination during dental treatment in maxillary and mandibular primary molars, compared to conventional anesthesia.

the study will be an eight-armed randomized controlled trial, parallel design. a total of 120 pediatric dental patients aged from 5 to 9 years with good health, will be selected from the pediatric dentistry and dental public health department clinic, faculty of dentistry, alexandria university, egypt. they will be recruited among those who need local anesthesia to perform either quadrant restorative treatment or extraction of their primary molars. participants will be allocated into 2 groups according to the local anesthetic technique to be used. children in the test group will receive intraosseous anesthesia using quicksleeper5, while inferior alveolar nerve block or infiltration anesthesia will be used for those who are in the control group. all the procedures will be videotaped. pain response upon needle prick and dental treatment will be assessed subjectively using the visual analogue scale, and objectively using face, leg, activity, cry, consolability scale. physiological parameters will also be recorded to determine pain reaction. efficacy, latency period and duration of anesthesia will be recorded for both injection techniques. child behaviour toward dental treatment in both injection techniques will be evaluated using frankl rating scale. dental anxiety of pediatric patients will be evaluated from the videotapes using venham clinical anxiety scale. postoperative assessment for the occurrence of any adverse events is planned.

Eligibility criteria:
inclusion criteria: * cooperative children during preoperative assessments. * patients selected in the restorative group: presenting with at least one primary molar indicated for restorative treatment or vital pulp therapy, after thorough clinical and radiographic examination. * patients selected in the extraction group: presenting with at least one primary molar indicated for extraction. exclusion criteria: * any physical or mental disability, or psychological problems. * immunocompromised patients. * hypersensitivity to local anesthetic drugs used * history of previous dental local anesthesia. * taking analgesics or other medications that would alter the child behavior or awareness of pain 12- hours pre-operative

Keywords: intraosseous anesthesia computer-controlled injection pain management dental anesthesia pediatric dentistry
pedometer-based behavioural intervention for individuals with copd to stay active after rehabilitation

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the star-study (stay active after rehabilitation) investigates in a randomized controlled trial (rct) the additional effect of a pedometer-based behavior change intervention (bci) during in-patient pulmonary rehabilitation (pr) on objectively measured physical activity (pa) 6-weeks and 6-months post pr. the bci uses the behaviour change techniques a) instruction on how, where and when to perform the behavior, b) prompt goal setting for physical activity, c) prompt self-monitoring of behavior and d) feedback on behavior. the primary outcome of pa will be measured using an accelerometer (actigraph wgt3x) for a time period of seven days, firstly two weeks before rehabilitation begins (t0 = study phase i) as well as six weeks and six months (t3 and t4) after pr. additionally to predict pa progression after pr, a complex personal diagnostic, including questionnaires as well as functional assessments, is to be carried out at the start (t1 = start of study phase ii) and end of pr (t2). this diagnostic is based on the main ideas of the pa-related health competence model (parc-model) and especially incorporates physical and psychological personal determinants of pa.

a detailed description will be available in the study protocol publication which is generated at the moment (august, 2016).

Eligibility criteria:
inclusion criteria: * main diagnosis for the pulmonary rehabilitation is an international classification of diseases-code j44.- (other chronic obstructive pulmonary disease) at all 2011 global initiative for chronic obstructive lung disease (gold) classifications a-d and stages 1-4. exclusion criteria: * considerably reduced health status (severe concomitant disease, which will affect the results of the outcome parameters, for example, cancer or severe cardiac, neurological or orthopaedic comorbidities) * considerable reduction of sight and hearing * severe psychiatric condition as secondary diagnosis * lack of ability to speak german

Keywords: pulmonary rehabilitation physical activity behaviour change pedometer
a study on higher-dose oseltamivir treatment's impact on viral clearance and clinical recovery in adults hospitalized with influenza

Conditions: Influenza; Respiratory Tract Infections

Summary: adult patients hospitalized with influenza have higher viral loads and more severe illnesses. thus more aggressive treatment approaches (e.g. higher dose oseltamivir) have been suggested to treat patients suffering from severe influenza infection. the investigators plan to investigate the impact of higher-dose oseltamivir (150 mg b.d.) treatment on viral clearance and clinical recovery in adult patients hospitalized for severe influenza. such information may lead to optimization of the management strategy used for these patients.

* the investigators plan to study the impact of higher-dose oseltamivir (150 mg b.d.) treatment on rate of viral load decline and rna negativity (in nasal and throat swabs, assessed by quantitative rt-pcr assay) and time to clinical recovery in adult patients hospitalized for severe influenza. * patients who received intervention (oseltamivir 150 mg b.d. for 5 days) will be compared to those in the non-intervention arm (patients may receive oseltamivir treatment at 75 mg b.d. for 5 days, decided by their managing physicians) in the two respective study sites. viral load changes and viral clearance will be compared. clinical progress and time to symptom recovery will be reported. the protocol will be crossed-over to the other site at a defined time frame. * oseltamivir 150 mg b.d. has been shown to be safe and well-tolerated in earlier clinical trials * higher-dose treatment has been suggested by health authorities (e.g. who) to treat severe influenza infection/pneumonia.

Eligibility criteria:
inclusion criteria: * confirmed influenza a (h1n1, h3n2) or b infection by ifa or rt-pcr, with a compatible clinical illness * presented within 96 hours from symptom onset * age \>/= 18 years exclusion criteria: * lack of consent * suspected avian influenza * patients who have received antivirals against influenza prior to admission * suspected or confirmed oseltamivir resistance * pre-existing renal impairment, with creatinine clearance \<40 ml/min * pre-existing hepatic failure * participation in a clinical study involving experimental medication in the past 4 weeks * pregnant women, or who are attempting to become pregnant, or who are breast feeding.

Keywords: severe influenza hospitalized adults oseltamivir treatment
effects of high-frequency in situ simulation-based team training on clinical performance during pediatric cardiac arrest

Conditions: Medical Education; Simulation-based Training; In-hospital Cardiac Arrest; Pediatrics; in Situ Simulation

Summary: cardiac arrest in hospitalized children is a rare occurrence in general and for each healthcare professional in particular, making lack of routine in performing cardiopulmonary resuscitation a challenge. mortality and morbidity following cardiac arrest depend on the technical (medical knowledge, procedures, etc.) and non-technical (team leadership, communication, etc.) skills performed by the medical team. simulation-based team training is a well-known and effective method to improve team performance in high-stake and time-sensitive situations, without putting actual patients at risk. unfortunately, studies show that skills obtained during simulation-based team training decline within a few months. however, recent observational studies have demonstrated improved technical pediatric basic life support skills after short simulation sessions with a high frequency of repeat. the healthcare professionals in these studies are limited to selected groups and tests are performed exclusively on skill stations. in this study, the effects of a novel high-frequency training program will be investigated. a controlled intervention study in two comparable danish regions will be conducted. healthcare professionals in four pediatric departments in the intervention region will participate in the high-frequency training program. healthcare professionals in four pediatric departments in the control region will continue simulation-based team training with no changes - "as usual" and at a two to three times lower frequency (based on unpublished data). both groups consist of approximately 600 healthcare professionals, contributing to a total of 1,200 participants included in this project. hypotheses: high-frequency training will improve primary outcomes during in-situ simulated pediatric in-hospital cardiac arrest as specified: 1. teamwork competencies measured by the team emergency assessment measure (team), 2. time (seconds) to recognition of cardiac arrest. 3. time (seconds) to initiation of cardiopulmonary resuscitation. 4. longest chest compression pause duration. data collection. to assess clinical performance in both regions unannounced in-situ (in own department with usage of own equipment) simulations of pediatric cardiac arrest will be performed and recorded on video.


Eligibility criteria:
inclusion criteria: * healthcare professionals (doctor or nurse) employed in one of the eight pediatric departments in central denmark region og southern denmark region during the project period april 1st 2023 to april 1st 2024. exclusion criteria: * missing consent to be recorded

Keywords: in-hospital cardiac arrest medical education simulation-based training pediatrics