Kornimate/medical-research-clean huggingface dataset:
go/no-go intervention for weight loss

Conditions: Overweight and Obesity

Summary: the purpose of this study is to assess the effect of a food-specific go/no-go (gng) computerized training task on weight loss, food evaluation, and disinhibition in a population of overweight and obese individuals.

within the current obesogenic environment, the prevalence of overweight and obesity has dramatically increased over the past 40 years. as a result, approximately 40% of americans attest to being on a diet, with most of these efforts being unsuccessful. most weight loss diets rely on self-control and reflective thinking (e.g., making conscious food choices multiple times per day), despite the fact that responses to appetitive foods often occur through implicit (unconscious) processes. the proposed study is a randomized clinical trial for weight loss that targets these implicit processes through the use of a computerized, food-specific, go/no-go task. this task has previously resulted in reduced food consumption in laboratory settings, and small but significant weight loss in two brief intervention studies. the purpose of this study is to replicate one prior study and to compare different doses of the intervention. participants will be assigned to one of three groups: high intensity, low intensity, or active control, and will be assessed on a number of variables pre- and post-intervention. changes in body weight, food evaluation, frequency of self-reported food consumption, and eating disinhibition scores will be evaluated. it is hypothesized that individuals receiving the food-specific go/no-go training (high intensity and low intensity groups) will experience greater weight loss, decreased disinhibition with food, and reduced snacking of the targeted foods than those in the active control group. it is also hypothesized that the high intensity intervention will be more effective than the low intensity intervention across these variables. moderators (e.g., dietary restraint, disinhibition) will also be explored throughout this study, along with the mechanism of devaluation of specific foods.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) ≥ 25 * age ≥ 18 * consume some of the determined "no-go" snack foods at least three times per week (assessed using a food frequency questionnaire) * a desire to lose weight exclusion criteria: * medical condition limiting dietary intake * medical condition directly affecting weight * current use of weight loss medication * actively enrolled in a formal weight loss program currently or within the past 6 months (e.g., weight watchers) * history of bariatric surgery * currently pregnant * current smoker * smoking cessation within the past year
treatment of bilateral maxillofacial post-traumatic deformities

Conditions: Therapeutics of Bilateral Maxillofacial Injuries

Summary: combined application of surgery planning software and rapid prototyping technology and preshaped titanium plates can effectively promote the accuracy of the diagnosis and treatment of bilateral maxillofacial post traumatic deformities, reduce operation time and improve surgical effect.

all patients underwent preoperative ct scan. firstly, surgicase were used to analyze ct data and design preliminary surgery plans. secondly, three-dimensions resin skull models were produced by rapid prototyping technology. model surgeries were performed to determine the location, reduction direction and shift distance of osteotomy. based on the surgical simulation, the preliminary surgery plans were validated and optimized. then, the titanium plates and mesh were preshaped on the models. finally, according to the final surgery plans the operations were performed. the operation time, therapeutic effects and complications were observed. the follow-up periods were 1-12 months.

Eligibility criteria:
inclusion criteria: * bilateral maxillofacial post-traumatic deformities exclusion criteria: * unilateral maxillofacialpost-traumatic deformities
fanconi syndrome due to arvs in hiv-infected persons

Conditions: HIV Infections; Fanconi Syndrome; Kidney Disease; Renal Impairment

Summary: cross-sectional cohort study of participants with hiv with or without protocol-defined fanconi syndrome (confirmed creatinine clearance \[clcr\] decline and evidence of proximal tubulopathy).


Eligibility criteria:
inclusion criteria - fanconi cases subjects must meet all of the following inclusion criteria to be eligible for participation in this study. * adult (greater than or equal to 18 years) hiv-1 infected subjects regardless of race or ethnicity. * subjects must be on a stable arv regimen for greater than or equal to 1 month prior to study entry. * evidence of protocol-defined fanconi syndrome * tdf subjects must be on tdf-containing regimen at the time of onset of fanconi syndrome. * negative serum pregnancy test (females of child-bearing potential only). * less than two years post-menopausal women of child-bearing potential (tdf subjects only) agree to follow an adequate birth control barrier method or agree to abstain from heterosexual intercourse while participating in the study. * the ability to understand and sign a written informed consent form, which must be obtained prior to initiation of any study procedures. exclusion criteria - fanconi cases subjects who meet any of the following exclusion criteria are not to be enrolled in this study. * non tdf subjects who have received any tdf within the prior 6 months, or those who have received greater than 2 weeks cumulative treatment. * tdf subjects who have previously served as a tdf control for this protocol. * history of current alcohol or substance abuse judged by the investigator to potentially interfere with laboratory results. inclusion criteria - controls subjects must meet all of the following inclusion criteria to be eligible for participation in this study. * adult (greater than or equal to 18 years) hiv-1 infected subjects regardless of race or ethnicity. * no evidence of protocol-defined fanconi syndrome * on a tdf-containing regimen matched to a fanconi case by clinic location, duration on tdf and age. * negative serum pregnancy test (females of child-bearing potential only). * the ability to understand and sign a written informed consent form, which must be obtained prior to initiation of any study procedures. exclusion criteria - controls subjects who meet the following exclusion criteria are not to be enrolled in this study. • history of current alcohol or substance abuse judged by the investigator to potentially interfere with laboratory results.

Keywords: fanconi kidney renal hiv hiv-1 treatment experienced
covid-19 vaccine response in chronic respiratory conditions

Conditions: SARS-CoV Infection

Summary: the investigators will assess the antibody, t cell and b cell responses to sars-cov-2 vaccination before and every 3 months for 18 months after the initial vaccination or subsequent vaccinations (boosters) in adults and children including patients with chronic medical conditions.

hypotheses 1. patients with chronic respiratory diseases will have a lower antibody response to sars-cov-2 virus after vaccination and shorter durability of the response than control subjects without chronic disorders. 2. patients on corticosteroids and other immunomodulator medications for chronic medical disorders will have a lower antibody response to sars-cov-2 after vaccination and shorter durability of the response than subjects with chronic disorders who are not being treated with corticosteroids and immunomodulator medications. specific aims 1. enroll up to 1,000 patients receiving a sars-cov-2 vaccination (initial or subsequent vaccinations) in an observational study to determine vaccine antibody response and durability. 1. obtain blood samples to measure antibody assess the antibody, t cell and b cell responses to sars-cov-2 vaccination before and every 3 months for 18 months after the initial vaccination or subsequent vaccinations (boosters) . 2. categorize patients by their age, gender, race, ethnicity, underlying chronic disease, disease severity, medical therapy and comorbidities. 3. assess the clinical effectiveness of the vaccine to prevent covid-19 infections. 3. determine the clinical features and gene expression of patients who are less responsive (have lower antibody levels and shorter duration of antibody response) to sars-cov-2 vaccinations. study design patient population - up to 1,000. consisting of patients in the following groups: 1. controls - who are not in any of the groups listed below. 2. previous covid infection 3. asthma receiving immunomodulator medications 4. asthma receiving chronic oral steroids 5. asthma - not receiving immunomodulator medications or chronic oral steroids 6. chronic obstructive pulmonary disease (copd) 7. rheumatoid arthritis receiving immunomodulator medications 8. rheumatoid arthritis not receiving immunomodulator medications 9. interstitial lung disease 10. cancer patients receiving chemotherapy 11. bronchiectasis 12. cystic fibrosis

Eligibility criteria:
inclusion criteria: * receipt of a sars-cov-2 vaccination exclusion criteria: * none
the effects of the novel unloading device "hephaistos" on bone, muscles and vessels

Conditions: Muscle; Atrophy, General

Summary: 11 healthy men used the hephaistos unloading orthosis in an ambulatory 8 week intervention study. it greatly reduces calf muscle forces without reducing ground reaction forces.

the 56day unloading intervention with hephaistos had the following key objectives: 1. primary objective: assessment and evaluation of bone adaptation. 2. secondary objective: assessment and evaluation of functional and structural muscular adaptations. 3. third objective: assessment and evaluation of functional and structural vascular adaptations. 4. fourth objective: assessment and evaluation if the present findings deviate from findings observed in established unloading models.

Eligibility criteria:
inclusion criteria: * male * age: 20-45 * bmi: 20-30 exclusion criteria: * smoking * professional sports men * diabetes * rheumatism * muscle and joint disease * bone fractures within 12 months prior to the study * cruciate ligament rupture within 10 years prior to the study * metal implants * participation in any other clinical study within 2 months prior to the study haemophilia * any blood vessel disease * epilepsy * claustrophobia * herniated disk * cardiac pulse generator * drug or alcohol abuse * hyperlipidaemia * kidney disease * hyperhomocysteaemia * hyper/hypouricemia * hyper/hypocalcaemia * anaemia * vitamin d deficit * chronical back pain * deficient certificate of good conduct * achilles tendon injury

Keywords: weight bearing muscle unloading bone loss arterial adaptation muscular adaptation
g7 acetabular system with vivacit-e or longevity liner pmcf study

Conditions: Total Hip Arthroplasty; Degenerative Joint Disease of Hip; Avascular Necrosis of Hip; Rheumatoid Arthritis of Hip; Osteoarthritis, Hip; Osteoarthritis of Hip; Fractures, Hip; Fracture of Hip

Summary: the main objectives of this study are to confirm the long-term safety, performance, and clinical benefits of the g7 acetabular shells when used with the vivacit-e and longevity hxlpe liners and instrumentation in primary and revision total hip arthroplasty.

the primary endpoint is defined by the survival of the implant system at 10 years, which is based on removal or intended removal of the study device and will be determined using kaplan meier method. the safety of the system will be assessed by monitoring the frequency and incidence of adverse events. relation of the events to either implant or instrumentation should be specified. the secondary endpoints are the assessment of performance and clinical benefits by recording patient-reported clinical outcomes measures (proms) as well as radiographic outcomes (if available).

Eligibility criteria:
inclusion criteria: * patient must be a legal adult who has reached full skeletal maturity. * patient must be treated for one of the following indications: * noninflammatory degenerative joint disease including osteoarthritis and avascular necrosis * rheumatoid arthritis * correction of functional deformity * treatment of non-union, femoral neck fracture, and trochanteric fractures of the proximal femur with head involvement, unmanageable by other techniques * revision procedures where other treatment or devices have failed * patient must be able and willing to complete the protocol required follow-up visits. * patient must be able and willing to sign the institutional review board or ethics committee (irb/ec) approved informed consent. exclusion criteria: * patient presents with osteoporosis, which in the opinion of the principal investigator, may limit the subject's ability to support total hip arthroplasty using the study device. * patient has a metabolic disorder that may impair bone formation. * patient has osteomalacia. * patient has distant foci of infections which may spread to the implant site or patient with infection, sepsis or osteomyelitis. * patient has rapid joint destruction, marked bone loss or bone resorption apparent on roentgenogram. * patient has a vascular insufficiency, muscular atrophy, or neuromuscular disease * patient is a prisoner. * patient is a current alcohol or drug abuser. * uncooperative patient or patient with neurologic disorders who is incapable or unwilling to follow directions. * patient is pregnant.
transarterial coil embolization of the superior rectal arteries for treatment of stage ii hemorrhoids

Conditions: Hemorrhoids; Embolization, Therapeutic

Summary: this study will evaluate short , mid and long term efficacy of transarterial coil embolization of the superior rectal arteries (emborrhoid techinque) for treatment the hemorrhoidal disease.

the 'emborrhoid' technique is the embolization of the hemorrhoidal arteries. the endovascular arterial occlusion is performed using coils placed in the terminal branches of the superior rectal arteries the emborrhoid technique has been modeled after elective transanal doppler-guided hemorrhoidal artery ligation, which has been shown to be safe and effective for hemorrhoidal disease. to date, there are few reports regarding emborrhoid, particularly lacking in long-term follow-up. additionally, all procedures reported so far have used a transfemoral access route, which requires at least one day of hospital stay. the aims of this study are: to increase data regarding safety and efficacy of the emborrhoid technique to report changes in the quality of life of patients at short and long-term to quantify recurrences at one-year follow-up to validate the use of the radial access for the emborrhoid technique to validate the emborrhoid technique as a "one-day" hospital procedure

Eligibility criteria:
inclusion criteria: * patients with at least grade ii hemorrhoids (banov et al. 1985), agreeing to undergo the embhorroid technique. exclusion criteria: * absolute contraindications to an angiographic procedure.

Keywords: hemorrhoids embolization, therapeutic
blood glucose monitoring in electronic health records

Conditions: Diabetes Mellitus

Summary: this multi-site randomized tral aims to test methods of increasing adoption and integration of blood glucose monitoring into electronic medical records, and to measure the impact of wide-scale adoption on health status of patients with diabetes. to investigate determinants of adoption, the research will combine and test doctor and patient focused approaches to encouraging patient use of blood glucose flow sheets through the online patient portal, mychart. adoption will be measured on both the extensive and intensive margin: the number of patients who enter data into the flowsheets at all during the study period, and the mean number of entries per patient during the study period. conditional on statistically significant increases in adoption, the study will examine corresponding intent-to-treat effects on patient a1c, and consider other indicators of possible mechanisms through which a1c improves or does not improve.


Eligibility criteria:
inclusion criteria: * adult patients of inova physicians at primary care sites other than ashburn ii primary care, lake ridge primary care and springfield primary care * current diabetes mellitus diagnosis * active mychart account at time of treatment administration exclusion criteria: * patients who participating physicians identify as pregnant * patients who participating physicians identify as having contraindications for tracking of blood glucose

Keywords: self monitoring of blood glucose electronic medical records nudge secure messaging behavioral economics
exploring the difference between gastric cardia cancer and non-cardia gastric cancer based on multiomics

Conditions: Stomach Neoplasm

Summary: this is an observational study with a case control design. this study included patients with gastric cancer confirmed by pathological diagnosis of gastric tissue, and matched the control population according to age, gender, etc. in this study, researchers collected clinical information and multiple biological samples such as saliva, serum, and feces from the study subjects. we combined 16s rrna sequencing and metabolomics to explore the differences in microbial and metabolic characteristics between gastric cardia cancer and non-cardia gastric cancer for early screening of gastric cancer.


Eligibility criteria:
inclusion criteria: * study population signing informed consent form * age: 18-75 years old * the study population must underwent endoscopic examination and was confirmed by pathological diagnosis as gastric cancer: including high-level intraepithelial neoplasia, early gastric cancer, and advanced gastric cancer. exclusion criteria: * those who have undergone gastrointestinal surgery within the past 1 year; patients who have undergone neoadjuvant chemotherapy and have developed tumors in the residual stomach after previous partial gastrectomy. * those who have used proton pump inhibitors, antibiotics, probiotics, and prebiotics daily within the past month, and those who have recently received hormone therapy. * people with infectious diseases and other digestive system diseases that interfere with the experimental results, such as inflammatory bowel disease, irritable bowel syndrome, etc.
korean version of the "quality of recovery 15" after general anesthesia

Conditions: Postoperative Complications

Summary: the aim of this study is to test the korean version of qor-15 for its validity and clinical acceptability and feasibility.

quality of recovery (qor) after anesthesia is an important measure of the early postoperative health status of patients. the qor-40 is a widely-used questionnaire for postoperative patients and the short-form version of it (qor-15) was developed in 2013. the validation of qor-15 has been reported in the version of english, portuguese, danish, chinese and swedish. however, the study to validate the korean version of qor-15 has not been demonstrated. patients undergoing surgery and general anesthesia are asked by the investigators to complete the qor-15 questionnaire and korean 36-item short form health survey (sf-36) a day before surgery. they are then asked to repeat the qor-15 questionnaire 24 h postoperatively and also rate their overall postoperative pain score using 11-point numeric rating scale (nrs).

Eligibility criteria:
inclusion criteria: * patients scheduled to undergo elective general surgery, thoracic surgery and gynecological surgery under general anesthesia * age between 18 and 80 years * willingness and ability to sign an informed consent document * ability to understand the contents of questionnaires exclusion criteria: * age under 18 or over 80. * do not understand our study * medical or psychological disease that can affect the treatment response
storytelling through music to improve well-being among homeless service providers

Conditions: Burnout, Professional; Anxiety; Depression; Secondary Trauma

Summary: homelessness is a complex social issue and requires a dedicated workforce of helping professionals, including nurses and social workers. secondary traumatic stress is common in this workforce and contributes to poor professional quality of life, burnout, and job turnover. these factors undermine the health and well-being of homeless service providers and threaten the stability of this critical workforce. the purpose of this study is to evaluate "storytelling through music," an innovative 6-week, multi-dimensional intervention, to improve well-being among homeless service providers.

research has found that the burden of secondary traumatic stress among homeless service providers (hsp) is similar to that among other healthcare professionals, including nurses working in urban emergency departments and in inpatient psychiatric hospitals. left unaddressed, secondary traumatic stress can cause compassion fatigue and emotional exhaustion, furthering a cycle of poor professional quality of life (qol), burnout, and job turnover. research has identified that arts-based interventions have promise in helping healthcare professionals cope with work-related emotions, assist in revealing genuine emotions linked to work-related stress, and in improving professional qol. what remains unclear is if arts-based interventions can yield similar benefits amongst hsps. the purpose of this study, therefore, is to evaluate the feasibility of implementing storytelling through music (stm) with hsps working with the homeless population in austin, texas. stm is a six-week intervention that combines storytelling, reflective writing, song-writing, and self-care skills to improve emotion regulation through affective and cognitive coping skills. our preliminary data suggests stm to be feasible and acceptable, and preliminary evidence demonstrates improved coping, psychosocial well-being, and burnout in nurses. specifically, this project aims to: aim 1: explore the contextual factors impacting the well-being of frontline hsps. aim 2: examine the feasibility of implementing storytelling through music with hsps. aim 3: investigate the preliminary intervention effect on coping (emotion regulation, self-compassion); well-being (anxiety, depressive symptoms, loneliness, post-traumatic growth, insomnia); and work-related factors (secondary traumatic stress, burnout, compassion satisfaction, and intent to leave).

Eligibility criteria:
inclusion criteria: * \>18 years old * employed in a homeless services organization in austin/travis county for at least 6 months * licensed as a nurse or social worker * ability to read and speak english * access to computer, internet, and zoom. exclusion criteria: * previous participation in the stm intervention

Keywords: burnout music intervention emotional well-being work-related stress
efficacy of somatropin in adult patients with isolated growth hormone deficiency

Conditions: Growth Hormone Deficiency

Summary: the study will investigate the effect on growth hormone replacement in patients with isolated growth hormone deficiency on body composition, especially visceral fat mass.

the study was terminated on 15-dec-2008 due to poor recruitment. although 9 patients were enrolled, no patient was randomized nor treated with somatropin. no safety reasons contributed to the termination.

Eligibility criteria:
inclusion criteria: * males and females between 18 and 65 years of age * isolated growth hormone deficiency exclusion criteria: * isolated growth hormone deficiency by childhood onset * diabetes mellitus type 1 or 2