Kornimate/medical-research-clean huggingface dataset:
rapid evaluation of acute kidney injury with ngal in acutely ill patients in the icu

Conditions: Acute Kidney Injury

Summary: this is a multi-center, prospective, observational study of patients that are admitted to the intensive care unit (icu). this study does not include any treatment or intervention and it is considered nonsignificant risk.

the study will be conducted in two phases. phase one is specimen acquisition and subject diagnosis adjudication. phase two is biomarker testing. phase one approximately 850 adults admitted to general icus will be enrolled within 12 hours of receipt of icu admission orders. study specific whole blood and urine specimens will be collected. there is an adjudication committee for this study. this committee is comprised of qualified, board-certified nephrologists. phase two during phase two, the plasma specimens will be divided amongst three clinical sites representative of the intended end users of this assay, and tested under a separate testing protocol.

Eligibility criteria:
inclusion criteria: * subjects must be 21 years of age or older. * subjects must be admitted to an intensive care unit (medical or surgical) and must be enrolled into this study within 12 hours of receipt of icu admission orders. * subjects must be assessed as likely to be alive in the icu for a minimum of 48 hours after enrollment. * the following plasma/serum creatinine values must be available: * subjects that are admitted to the icu following an elective surgery or procedure must have at least one pre-surgical/ pre-procedure creatinine value obtained in the 7 days prior to presentation to the icu. * subjects that are admitted to the icu for any reason other than following an elective surgery or procedure must have at least one creatinine value obtained greater than 7 days and up to 6 months prior to presentation to the icu. exclusion criteria * subjects either receiving or in imminent need of renal replacement therapy. * subjects with evidence of chronic kidney disease stages 4 and 5 as evidenced by a pre-enrollment estimated gfr of less than 30 ml/min/1.73m2 (according to the 4-variable mdrd22). * subjects with any obstructive uropathy at the time of presentation to the icu. * subjects with any known urothelial, urological or kidney malignancies. * subjects that have had any urologic procedure or surgery immediately prior to admission to the icu. * subjects that have had any renal transplant or nephrectomy. * subjects that have had cardiovascular surgery involving cardiopulmonary bypass within the previous 7 days. * subjects that have participated in an interventional clinical study within the previous 30 days including studies with any investigational and non-investigational drugs. * the inability to obtain written informed consent from the subject or an authorized representative. * subjects that have been previously enrolled in this study during a prior admission to the icu.
a phase iii clinical study to compare the efficacy and safety of da-3801 and that of gonal-f®

Conditions: Infertility; Anovulation

Summary: open label, active-controlled, randomized, parallel group, comparative study.

this is a phase iii comparative study to evaluate the effectiveness and safety of da-3801 in treatment of the patients with who group ii anovulatory infertility failing to clomiphene citrate treatment. the study is conducted with following methods: open label, active-controlled, randomized, parallel group, comparative.

Eligibility criteria:
inclusion criteria: * who group ii * clomiphene citrate resistance * bmi: 17\~29 kg/m\^2 * irregular menstrual cycle * normal blood concentration of fsh, e2, prolactin and tsh exclusion criteria: * uncontrolled endocrine disease * ovarian cystic tumor which are not related to pcos * severe endometriosis * chronic cardiovascular disease, liver complaint
comparative effect of neck isometrics and deep cervical flexion exercises on neck pain among breastfeeding females.

Conditions: Neck Pain; Range of Motion; Muscle Weakness; Breastfeeding

Summary: neck pain is a common complaint among breastfeeding females, potentially attributed to sustained postures and muscle imbalance. breastfeeding females experiencing neck pain, aged between 18-40 years, will be recruited through local healthcare facilities and community outreach. the physical demands of breastfeeding, such as prolonged postures and repetitive movements, can contribute to the development of musculoskeletal issues in the cervical region. despite the prevalence of neck discomfort among breastfeeding females, there is a paucity of research exploring effective exercise interventions tailored to this specific population. mothers' awareness of proper nursing positions during breastfeeding may have positive impact on the connection between mother and baby. most typical positions for nursing a baby are cross cradle hold, cradle hold, side lying and football hold. most common adapted breastfeeding position is cross cradle.

a randomized control trial will be conducted to assess and compare the effectiveness of neck isometrics and deep cervical flexion exercises in alleviating neck pain, reducing disability, improving range of motion, and addressing muscle weakness in breastfeeding females. a sample size of 48 lactating women will be taken. data will be collected from private clinical setups of bahawalpur by using (nprs) numeric pain rating scale questionnaire, (ndi) neck disability index, range of motion will be assessed by inclinometer and muscle strength will be assessed by mmt. a written consent form will be taken from participants meeting inclusion criteria and will be randomly allocated into two groups of equal members. group a will be given neck isometric exercises and conservative treatment for 30 min (3-4days/week) of duration for total 6 weeks. group b will be given deep cervical flexion exercises with conservative treatment. the interventions will be provided for 30 minutes for 3-4 day/week for 6 weeks. all participants in both groups will be evaluated before and after the treatment programs. outcome measures will be calculated after 6 weeks of intervention. data will be analyzed by using spss 21

Eligibility criteria:
inclusion criteria: * between the ages of 25 to 40 years * mode of delivery (vaginal/c-section) * severe neck weakness (above grade iii) * primigravida exclusion criteria: * previous history of upper extremity musculoskeletal symptoms * radicular neck pain * history of inflammatory disease (myelopathy) * history of cervical fracture

Keywords: neck pain range of motion muscle weakness breastfeeding
evaluating the impact of online educator microskill training on educator knowledge and skill

Conditions: HIV/AIDS Prevention; STI Prevention; Pregnancy Prevention

Summary: the goal of this clinical trial is to evaluate the efficacy of skilltalk, a subscription-based microskills video training library designed to enhance the skills of high school sex educators to implement the frequently used core components of sexual and reproductive health (srh) curricula. the overall goal of this study is to evaluate the impact of skilltalk on educators' demonstrable sexual health education skills. participants will be asked to: * complete a consent form. * attend two simulated classroom sessions, either in person or virtually, during which they will teach two prepared lessons that have will be provided to them. * be video recorded while teaching. * complete a baseline survey and a post-survey. * if assigned to the treatment group, they will be granted access to skilltalk for one week to view the videos associated with the answering sensitive questions and using trauma-informed strategies skill sets. researchers will compare the treatment group to the control group to see if skilltalk has an impact on educators' demonstrable sexual health education skills.


Eligibility criteria:
inclusion criteria: * teach or have taught groups of youth in a school, clinic or community setting. group is defined as 4 or more youth. youth is defined as high school aged youth in grades 9-12. * have fewer than three years of experience teaching sexual health education * comfortable participating in the role * must reside in the u.s. * must be at least 18 years of age.
clinical study of kw-2246 in patients with cancer pain

Conditions: Pain; Cancer

Summary: this study is a phase ii open-label study to investigate the recommended conversion ratio (oral morphine dose to kw-2246) when switching oral morphine or oxycodone to kw-2246 in cancer patients.

this study is a phase ii open-label study to investigate, using the continual reassessment method procedure by pain intensity and safety as indicators, the recommended conversion ratio (oral morphine dose to kw-2246) when switching oral morphine or oxycodone to kw-2246 in cancer patients who have been maintained on oral morphine or oral oxycodone for pain and to evaluate the safety and efficacy of kw-2246.

Eligibility criteria:
inclusion criteria: 1. provide written informed consent to participate in the study. 2. be able to be hospitalized. 3. between the ages of 20 and 80 years (inclusive) at the time of giving written informed consent. 4. have regularly received oral morphine or oral oxycodone at an oral morphine equivalent dose of 20 to 120 mg/day for at least 2 days before study entry, and not have required any rescue dose between regular doses. 5. not have experienced intolerable toxicity for 2 days before study entry. 6. have cancer that is in stable condition at study entry and expected to remain stable during the kw-2246 treatment period. 7. have a life expectancy of at least 1 month after the start of kw-2246 administration. 8. considered to be able to keep the patient diary. exclusion criteria: 1. serious respiratory dysfunction. 2. asthma. 3. serious bradyarrhythmia. 4. serious hepatic or renal dysfunction. 5. susceptibility to respiratory depression due to such conditions as increased intracranial pressure, head injury and brain tumor. 6. history of convulsive seizures (except a single episode of infantile febrile convulsions). 7. current or past history of drug dependence or narcotic abuse. 8. dry mouth that affects oral intake. 9. use of opioid analgesics other than oral morphine or oxycodone within 7 days prior to study entry. 10. use of narcotic antagonists within 7 days prior to study entry. 11. interventions that may affect pain evaluation, such as surgery, radiation to the pain site (including those sites that influence pain) and nerve block, within 7 days prior to study entry or scheduled to be given during the study. 12. patients with a history of serious adverse reactions to the combination of opioid analgesics and other drugs/substances who are currently receiving or expected to receive those drugs/substances combined to opioid analgesics. 13. history of hypersensitivity to fentanyl. 14. pregnant or lactating women, possibly pregnant women or women who are planning to become pregnant. 15. participation in any other clinical trial within 28 days prior to the start of kw-2246 treatment. 16. prior exposure to kw-2246. 17. patients whom an investigator judge unsuitable for enrollment.

Keywords: pain cancer neoplasm continual reassessment method pain associated with cancer/neoplasms
mental practice in motor learning of brushing and parkinson disease

Conditions: Parkinson's Disease

Summary: parkinson's disease (pd) is characterized by dopaminergic neurons degeneration of the substantia nigra, in the midbrain, resulting in the presence of motor disorders, such as tremor, rigidity, bradykinesia, and postural instability. researches have shown that mental rehearsal in learning motor skills through mental practice (mp), which associates the physical practice to somatosensory imagination to action, causes positive effects in several motor tasks, such as the speed of motion, muscle strength performance and accuracy. thus, this study aims to report the effects of mp as a tooth brushing training strategy in people with parkinson's disease. this project was approved by the ethics committee in research with human beings of ufpe and attempt to compare the presence of bacterial biofilm before and after 8 weeks of brushing through the mental practice training, based on o'leary's index. the sample consisted of 35 people, divided into two groups: intervention group consists of 17 people with parkinson's, in stages i to iii of the disease, who underwent brushing orientation associated with pm, and the control group people without the disease, who received only orientation brushing. then, the data were evaluated by factorial anova 2x2 and post hoc tukey test considering p \<0.05. it was observed that after the intervention was a significant improvement of the control dental biofilm.


Eligibility criteria:
inclusion criteria: * age between 40 and 80 years; * idiopathic pd clinical diagnostics according to the bank of brain london; * patients in stages i to iii according to hoehn and yahr; * satisfactory communicative and cognitive level checked by the mini-mental state examination; * subject to satisfactory clinical, lying in his home in the care of relatives; * patients who possessed a sextant of the dental arch with teeth. in the control group individuals without neurological disease were included: both sexes at ages similar to the group with pd, satisfactory health, active life, and natural teeth. exclusion criteria: * another neurological disease associated with pd; * mioarticulares abnormalities in the upper limbs to prevent their use for independent brushing; * use of orthotic / prosthetic hand; * toothless in both dental arches. in the control group were excluded individuals with mioarticulares abnormalities of the upper limbs; in use of orthotic / prosthetic hand; presenting any movement disorder in the upper limbs.
multimodal mri study of ischemic stroke

Conditions: STROKE

Summary: stroke is the second most frequent causes of mortality in the word after cardiovascular disease and the most frequent cause of disability. the majority of strokes are ischemic (87%). ischemic stroke may benefit from efficient therapy if the delay from stroke onset not exceeds 4h30 (intra-venous thrombolysis). in case of irreversible cerebral lesion, the long term functional recovery is largely dependent from the ability of the brain to reorganize. conventional magnetic resonance imaging represents the most sensitive tool to diagnose stroke at the acute phase. however, up to now, no imaging tool is available to determine the time of stroke onset. moreover, no imaging tool is available to precisely quantify the functional and structural plasticity mechanisms occurring after stroke. the main objective of the present study is to test the accuracy of sodium mri to determine the time of stroke onset. the secondary objectives of the study are to determine the ability of non-conventional mri techniques to quantify the degree of tissue damage and brain reorganization after stroke. thirty patients will be included during the first 24 hours after stroke onset. multimodal mri (including perfusion mri, sodium mri, resting-state functional mri, high resolution anatomical mri) and clinical evaluation will be carried on at the inclusion, after 24 hours, at 3 months and at 12 months.


Eligibility criteria:
inclusion criteria: - patient having presented a cerebral infarct beforehand confirmed by the brain imaging * patient having presented a cerebral infarct the hour of the beginning of which is known with certainty and dating less than 24 hours * patient having presented a cerebral infarct the area(extent) of which is superior to 1,5 ml exclusion criteria: * patients presenting the usual contraindications to the mri (pacemaker, agitation, metallic brightness, claustrophobia etc.) * patients presenting a risk of not compliance to the examination: disorders(confusions) of the elementary understanding, the confusion, the involuntary movements, the bad tolerance of the prolonged dorsal decubitus
observational analysis of the cause of leaks when bowel is cut and reconnected

Conditions: Anastomotic Leaks

Summary: the purpose of this study is to identify the cause of leaks that sometimes occur after a section of the bowel is removed and reconnected. certain staplers from the operating room will be collected and sent to a third party (ecri institute) to be examined for defects. the patient's charts will be analyzed for medical issues that may contribute to leaks after surgery.

the objective of this study is to identify peri-operative factors that contribute to leaks after a portion of the bowel has been cut and reconnected. most specifically, the role of staplers in this reconnection of the bowels will be evaluated. the research will take place at icahn school of medicine where there is an extremely high volume of operations involving small bowel and large bowel being cut and reconnected. patients will be recruited based on inclusion and exclusion criteria and 500 subjects are expected to be enrolled in the study. the surgery will be performed in a standard fashion as indicated by diagnosis, location of disease, patient condition, and surgeon preference. no changes to the surgical procedure will be mandated by the research protocol. this is purely an observational study with no changes to the standard of care. the patients will be followed throughout the course of the their hospital stay for the scheduled surgery up to one week and one month after the procedure to gather laboratory data and any complications incurred due to the surgery. no patient specimen will be stored. the staplers used in the procedure will be collected, stored in sterile plastic container, information about the staplers will be recorded, and then discarded after 30 days in the usual manner that the operating room staff employs to discard the staplers. subjects lost to follow-up after the procedure will be withdrawn from the study.

Eligibility criteria:
inclusion criteria: * subject must be scheduled for non-emergent small or large bowel surgery and reconnection of bowel at icahn school of medicine at mount sinai * subjects must be able and willing to provide informed consent * subjects must be 18 years or above or 15-17 with permission of one parent * english and spanish speaking patients will be included in this study exclusion criteria: * subject who are less than 15 years of age * subject who are scheduled for emergent surgery, precluding the capacity to give informed consent * subjects who are diagnosed with obstructed or perforated colon cancer

Keywords: anastomotic leaks bowel resection postoperative complication
understanding physician signout risk perception

Conditions: Physician Judgment

Summary: the purpose of the study is to compare the ability of physicians and a statistical index (the rothman score) to predict clinical deterioration over the next 24 hours. clinical deterioration is defined as concern in change in vital signs or patient status requiring a call to the rapid response team, cardiopulmonary arrest, or transfer to the icu.

the proposed study will ask interns, residents, and attending physicians from general internal medicine teaching teams in a large teaching hospital to make predictions about the probability of their patient having a clinical deterioration in the next 24 hours. the investigators will compare these judgments to the rothman index.

Eligibility criteria:
inclusion criteria: * interns, residents, attendings in the department of medicine, division of general internal medicine, university of pittsburgh. * rotating on the general medical service at the university of pittsburgh medical center - presbyterian hospital. exclusion criteria: * none

Keywords: judgment risk assessment clinical deterioration cardiac arrest rothman index
value of fecal calprotectin

Conditions: Calprotectin; Inflammatory Bowel Disease

Summary: for the main goal - the accuracy of calprotectin for the diagnosis of ibd - calprotectin levels will be compared between patients with and without a diagnosis of ibd and the sensitivity, specificity and accuracy will be determined. for the secondary aim - the correlation between calprotectin levels and disease activity - in patients with ibd selected from this cohort, we will determine the association between calprotectin levels and clinical ibd score, serological markers (wbc, hgb, platelets, esr, crp, albumin), endoscopic (disease score, pathological activity) and radiological features (bowel wall thickening, enhancement, edema, mesenteric inflammation).


Eligibility criteria:
inclusion criteria: * calprotectin assay at iu in last 12 months
redapt revision hip system with rsa

Conditions: Hip Osteoarthritis

Summary: the principal objectives of the study are to evaluate early and mid-term fixation of the redapt revision hip stem and acetabular cup as measured by stem subsidence and proximal cup migration at 2 and 5 years post-surgery through model-based rsa. secondary objectives include; evaluate the progression of migration between 1 and 2 years and between 2 and 5 years, assess pre- to post-surgery patient improvement in function and health status, evaluate femoral and acetabular radiolucency at 2 and 5 years, and assess patterns of stem migrate on for different revision scenarios (preservation of the trochanters and extended trochanteric osteotomy).

this is a prospective, single arm, consecutive series study of patients undergoing revision hip arthroplasty. patients will be grouped based on the revision implants they receive during surgery. patients who receive a full hip revision (stem and cup), will be counted in both study groups. the two study groups are: 1. femoral stem revision (n=30 hips) 2. acetabular cup revision (n=22 hips)

Eligibility criteria:
inclusion criteria: * patients needing revision hip arthroplasty in which either the femoral stem or the acetabular cup, or both components, will be revised * ability to use study device (not requiring specialized implants) * patients between the ages of 18+ older * patients willing and able to comply with follow-up requirements and self-evaluations * ability to give informed consent exclusion criteria: * acute infection requiring washout, debridement, and liner exchange * unresolved infection * undergoing stage 1 of a 2-stage revision for infection * known metal allergy to device components * active participation in another clinical study (within the past 30 days) * known risk for loss to follow-up (significant geographical distance from treatment centre) * bmi\>40 (severe obesity) * unable to provide informed consent (cognitive impairment) * patients requiring a bearing couple different than metal on polyethylene * patients requiring extreme distal press-fit revision stems (greater than 240 mm in length) * patients with severe defects, dysplasia, or tumor * inflammatory joint disease