Kornimate/medical-research-clean huggingface dataset:
role of pepsin assay in wheezy infants

Conditions: Gastroesophageal Reflux Disease

Summary: wheezy infants were tested for gastro-esophageal reflux disease (gerd) using combined multiple channel intraluminal impedance-ph (mii-ph), esophagogastroduodenoscope (egd), lipid laden macrophage index and bal pepsin. wheezy infants with abnormal mii-ph or reflux esophagitis were given domperidone and omeprazole then re-evaluated for symptoms control and exacerbations recurrence.

wheezy infants were tested for gastro-esophageal reflux disease using combined mii-ph, egd, llmi and bal pepsin. wheezy infants with abnormal mii-ph or reflux esophagitis were given domperidone and omeprazole for 12 weeks then re-evaluated for symptoms control and wheeze exacerbations recurrence.

Eligibility criteria:
inclusion criteria: * infants with physician documented 3 attacks of wheezing episodes over the last 6 months or persistent wheeze over the last one month exclusion criteria: * wheezy infants with atopy (allergic rhino-conjunctivitis or eczema), prematurity (less than 34 weeks), abnormal neurological examination, congenital heart diseases, airspace opacity on chest radiography, tracheal-bronchial malformations, immune deficiency and anatomical esophageal or gastric malformations
a communication-priming intervention to improve shared decision-making between older adults with advanced ckd and clinicians

Conditions: Chronic Kidney Disease Stage 4; Chronic Kidney Disease Stage 5

Summary: to achieve the goal of reaching consensus about the preferred treatment option that best aligns with the goals and values of patients, the investigators developed a 'ckd jumpstart- tips" priming tool tailored for older adults with advanced ckd that is based on communication principles from vitaltalk and elwyn's goal-based sdm model. the investigators hypothesize that compared with patients in the usual care group, patients in the 'ckd jumpstart- tips' intervention group will have: 1. increased level of shared decision-making (observer-based and patient-reported), 2. improved quality of communication, 3. increased patient involvement in decision-making, 4. lower decisional conflict, 5. lower decision regret, 6. decreased time to decision, 7. improved adherence to treatment choice, and 8. improved health-related quality-of-life.

to enhance the communication on shared decision-making between older adults with advanced kidney disease and clinicians, the investigator's research team developed the "ckd jumpstart- tips" communication-priming intervention. this study aims to conduct a cluster-randomized controlled trial to assess the effects of the 'ckd jumpstart- tips' communication-priming intervention on shared decision-making between older adults with advanced kidney disease and their clinicians. the primary objective of the study is to evaluate the effects of the intervention on observer-based shared decision-making in the target consultation. the secondary objective is to evaluate the effects of intervention on patient-reported shared decision-making, quality of communication, patient involvement in decision-making, decisional conflict, decision regret, timing of and adherence to treatment choice, and health-related quality of life. consultation length will also be captured as a process measure.

Eligibility criteria:
inclusion criteria for the two groups of participants (i.e. clinicians and patients): 1. clinicians - nephrology specialists or higher physician trainees who provide specialty care to older adults with advanced chronic kidney disease 2. patients * diagnosis of advanced ckd stage 4 or 5 (egrf \<30 ml/min) * chinese- or english-speaking * identified as patient with whom their clinician plans to discuss advanced kidney disease treatment options in the upcoming clinic visit * able to provide written informed consent and complete questionnaires * can be contacted by phone exclusion criteria for patients: * patients will be excluded if they are eligible for kidney transplant, currently on dialysis, or lack decision-making capacity

Keywords: communication priming decision-making older adults chronic kidney disease ckd-priming jumpstart
pharmacokinetics of procaterol in elite athletes

Conditions: Asthma

Summary: the purpose of the study is to find blood and urine concentrations of procaterol administrated either by inhalation or by tablets in asthmatic and non-asthmatics males. we hypotheis that the concentrations of procaterol in the blood and serum is higher after tablet intake versus inhalation.

doping study

Eligibility criteria:
inclusion criteria: * doctor diagnosed asthma for the asthmatic group * gina 1-3 for the asthmatic group * use of beta2-agonist for at least 12 months for the asthmatic group * age 18-45 * males * informed consent exclusion criteria: * smoker or former smoker * airway infection to weeks prior to the study or during the study * other chronic diseaes than asthma and allergy * use of beta2-agonist 6 days prior to the study * allergy to the study medicine

Keywords: elite athletes
can 3d laparoscopy improve surgical performances in surgeons in training?

Conditions: Uterine Fibroid; Uterine Bleeding; Uterine Prolapse

Summary: due to the inconclusive results on the benefits of 3d laparoscopic system present in literature, this prospective randomised pilot study aims to assess if the operative time of total laparoscopic hysterectomy (tlh) for benign indication performed by trainees could be reduced using 3d laparoscopy instead of standard laparoscopy.

all patients with benign uterine pathology at preoperative examinations (pelvic ultrasound and/or magnetic resonance and/or ct scan) and with indication for total laparoscopic hysterectomy, will be enrolled in the study. while under general anesthesia, the patient is positioned in the dorsal lithotomic position with both legs supported in stirrups with a trendelenburg tilt and arms along the body. a four disposable or reusable, sterile trocar transperitoneal approach is used. a 10 mm port is inserted at the umbilicus for the telescope. once pneumoperitoneum (12 mmhg) is achieved, intra-abdominal visualization will be obtained with a 0° high-definition telescope (hd endoeye 10 mm, olympus winter \& ibe gmbh, hamburg - germany) or with 0° 3d laparoscopy high-definition (olympus winter \& ibe gmbh, hamburg - germany). the instruments used include bipolar grasper, monopolar scissors, monopolar hook, various graspers and a suction irrigation system. clermont ferrand uterine manipulator (model k.storz endoskope,tuttlingen, germany) is optionally used to move the uterus. total hysterectomy is then performed according to standard technique used by the recruiting center (development of the pararectal space and identification of uterine artery, coagulation of ovarian pedicles, development of the vesico-uterine septum, colpotomy).the vaginal vault is then closed with a 0 vycril suture laparoscopically (continuous suture). detailed operative time, intra and post operative early complications will be recorded (extended clavien-dindo classification of surgical complications will be used for post operative complications)

Eligibility criteria:
inclusion criteria: * patients suffering from benign uterine pathology (uterine fibromatosis, abnormal blood loss, complex hyperplasia with atypia, uterine prolapse) with indication for total uterine hysterectomy * uterine size \</= than 15 cm * american society of anesthesiologists (asa) class \< 3 * patient's informed consent * no actual pregnancies or pelvic inflammatory disease * no previous major abdominal surgical procedures exclusion criteria: * suspected neoplastic pathology * patients not eligible for surgery

Keywords: 3d laparoscopy 2d laparoscopy surgeons in training
binaural beats dysmenorrhea and sleep quality

Conditions: Dysmenorrhea Primary

Summary: the research is a randomized controlled trial. the sample group will consist of 120 people; 60 participants will be included in the experimental group, and 60 will be included in the control group. in the study, the participants in the experimental group will listen to the alpha sound for pain for 10 minutes and the delta sound for sleep for 15 minutes via the mobile application three days a week. the researchers will not intervene with the control group during the study. during the study, only the data collection tabs of the mobile application will be active for the control group, and the use of the sounds will be opened at the end of the study. the study data were used in the personal identification form, menstruation symptom scale, pittsburgh sleep quality index, and women's health initiative insomnia scale.

binaural beats are based on creating a physiological response by applying sound at different frequencies to both ears. the brain perceives the sound given at different frequencies to both ears as a single frequency. the perception of different frequency sounds as a single frequency is called binaural integration. eeg studies suggest that binaural beats can affect electrocortical activity; that is, they can modulate the frequency of neuronal oscillations without requiring prior training. binaural beats application reduces pain, anxiety, and stress and improves sleep quality in individuals. binaural beats is a non-pharmacological application that does not require any training before application. no side effects have been reported in the studies conducted in the literature, and it is also emphasized that it is an effective, cheap, safe, and non-pharmacological application. from this point of view, this study aims to determine the effect of binaural beats on sleep quality and dysmenorrhea during menstruation.

Eligibility criteria:
inclusion criteria: * being over 18 years old * having headphones (for the experimental group) * having pain of 4 and above according to the numerical pain scale * taking a women's health and diseases nursing course * not using medication during menstruation * not using sleeping pills * being single * not using contraceptives * not having a hearing problem * not having a psychiatric problem * not having alcohol or substance addiction constitutes the inclusion criteria of the study. exclusion criteria: * not listening to binaural sounds for two days or more on the days specified in the mobile application * using analgesics during menstruation while the study is ongoing * experiencing irregular menstrual bleeding in the last three months constitutes the study's exclusion criteria.

Keywords: dysmenorrhea primary pain sleep quality binaural beats
the utility of regional bioimpedance in chronically ventilated patients

Conditions: Chronic Respiratory Failure

Summary: chronically ventilated patients will be hemodynamically measured by bioimpedance (nicas by ni medical ltd.) for cardiac output, total peripheral resistance and other nicas derived parameters. patients fluid balance will be planned according to these parameters and the rate of liberation from ventilator and rate of worsening renal function will be measured

patients will be divided into two groups , the study group and the control group randomly assigned by a computer program . after obtaining written informed consent , cardiac monitoring will be carried out by means of a nicas patients in both groups.the physician will not be exposed to the measurement data of the patients in the control group. for the research group : monitoring will be carried out once a day , preferably at the same time the first three days . an increase in time interval is possible in accordance with an improvement in the patient . patients will be treated according to the protocol described in figure 1. also , a graphic description of the various treatment zones and the exclusion zone is presented in figure 2 . for the control group patients will be treated according to the usual ward protocols. the basic rules are: avoiding over- drying by using parameter tbw . * avoidance of renal dysfunction by maintaining the cardiac output above 2.3 , and avoiding the use of beta-blocker overdose in cases of low cardiac output and bradycardia as a result of maintaining an average blood pressure over 70 . * in cases of high peripheral resistance - reduction of resistance while maintaining normal blood pressure .

Eligibility criteria:
inclusion criteria: * all chronically ventilated patients (ventilated for more than 14 days) * age between 18-90 exclusion criteria: * non ventilated patient * total body water \>80%
french registry of acute coronary syndrome

Conditions: Acute Myocardial Infarction

Summary: the fast-mi registry was designed to evaluate the "real world" management of patients with acute myocardial infarction (mi), and to assess their in-hospital, medium and long-term outcomes

primary objectives : compare survival following the admission to a usic according to the terms of care

Eligibility criteria:
inclusion criteria: * admission within the 48 hours after the occurence of acute myocardial infarction (ami) * written informed consent for the dna and serum databank exclusion criteria: * ami occured within the 48 hours after therapeutic intervention (bypass, coronary angioplasty or other chirurgical intervention) * diagnostic of ami not confirmed

Keywords: coronary syndrome myocardial infarction french registry
the role of myocardial fibrosis in patients with aortic stenosis

Conditions: Aortic Stenosis

Summary: aortic stenosis is the most common adult valvular heart disease in the western world. heart failure and sudden cardiac death are complications associated with aortic stenosis. in symptomatic individuals, valve replacement is often the only effective treatment. however, there are no good markers to identify patients who may benefit from early surgery before symptoms developed. the purpose of the study is to test the hypothesis that the presence heart muscle scarring on the cardiac magnetic resonance imaging may predict a worse outcome in patients with aortic stenosis, and thus may be helpful in identifying patients for early valve replacement.

congestive heart failure and sudden cardiac death are associated complications of aortic stenosis. currently, the indications for valvular replacement are based on the valvular severity evaluated by echocardiography and the presence of symptoms. there is some evidence to suggest the presence of myocardial fibrosis is associated with a poor outcome in patients with aortic stenosis. the aim of this prospective study is to investigate the prognostic implications of myocardial fibrosis in patients with aortic stenosis. the presence of myocardial fibrosis will be identified by delayed enhancement with the cardiac magnetic resonance imaging at 3t. we will also be evaluating the application of t1 mapping techniques to detect diffuse myocardial fibrosis.

Eligibility criteria:
inclusion criteria: * patients with aortic stenosis * willing to undergo all investigations exclusion criteria: * coexisting mitral valvular heart disease and aortic regurgitation (more than moderate severity) * active medical conditions: ongoing heart failure, infection * significant comorbidities: advanced malignancy with limited life expectancy * unable to give informed consent * contraindication for cardiac magnetic resonance imaging: impaired renal function, pacemaker, claustrophobia

Keywords: aortic stenosis cardiac magnetic resonance imaging late gadolinium enhancement t1 mapping techniques replacement fibrosis diffuse interstitial fibrosis
improving medication adherence among people with schizophrenia through the use of 2-way pagers

Conditions: Schizophrenia

Summary: this study will determine whether using a pager improves medication adherence in people with schizophrenia.

schizophrenia is a life-long brain disorder affecting approximately 1 percent of americans each year. schizophrenia can be extremely disabling, causing people to hear voices, experience paranoia or hallucinations, and believe that others are controlling their thoughts. many people with schizophrenia have difficulty with remembering their scheduled doctor's appointments and with taking their medication on time because of their mental illness. many approved medications for schizophrenia must be taken several times a day and side effects such as drowsiness, dizziness, and even weight gain can deter a person from consistently taking their medication on time. therefore, this study will determine whether a 2-way pager will help people with schizophrenia to remember their doctor's appointments and to take their medication on time. participants in this open-label study will first complete several written tests to assess skills such as memory, attention, and problem solving. participants will also be asked questions regarding their current symptoms and medication regimen. participants will then be randomly assigned to receive either treatment as usual or treatment as usual and a 2-way pager for 6 months. participants who receive a 2-way pager will attend approximately four information sessions. during these sessions, participants will learn how to program the pager and use a specially designed medication bottle cap that will record the number of bottle openings and the date and time of each opening. at designated times, the pager will vibrate or beep, alerting participants to take their medication or attend a scheduled appointment. all participants will meet weekly with a staff member for the first month and then once a month for the remaining 5 months to complete several brief questionnaires on pager use, assess medication adherence, and discuss any symptoms experienced within the past week or month. participants will be required to bring their medication to each meeting to ensure compliance.

Eligibility criteria:
inclusion criteria: * meets dsm-iv criteria for schizophrenia or schizoaffective disorder * admitted to the zucker hillside hospital for exacerbation of illness * speaks english exclusion criteria: * presence of severe visual or motor impairments * mental retardation * neurologic disorder that may impact functioning such as seizures or vascular, neoplastic, traumatic, or infectious disorders affecting the brain * prescribed a psychotropic drug in depot form * after hospital discharge, a living or treatment situation that includes dispensing of full medication regimen

Keywords: schizoaffective disorder
skeletal stability of le fort i osteotomy using patient-specific osteosynthesis compared to mini-plate fixation for patients with dentofacial disharmony

Conditions: Dentofacial Deformities

Summary: the aim of the study is to evaluate the skeletal stability of le fort i osteotomy using patient-specific osteosynthesis compared to mini-plate fixation for patients with skeletal class iii malocclusion.

postsurgical relapse is one of the most common observations that have been reported after fixation of le fort i osteotomy cases. fixation systems with plates and screws are used in oral maxillofacial surgery for the treatment of facial fractures and orthognathic surgery cases. although they have been used for decades and have become the standard treatment, the materials used in these systems may fail due to excess loading and other causal factors during the surgical procedure, including failure in plate adaptation and fixation to bone, material design, fabrication, and degree of purity of the plate material. in the fixation system, non-customized plates of standard size are used, and are bent to adapt them to the distances required for planning orthognathic surgeries. therefore, mandatory use of larger plates than those programmed for use in surgeries is required so that they can be bent to enable insertion. moreover, there are variations in the number of screws required to retain the plates to enable better fixation. the folds of non-customized plates generate stresses that are minimized when using customized plates, because these plates are fabricated individually, with predetermined sizes for each patient.

Eligibility criteria:
inclusion criteria: 1. patients with skeletal class iii malocclusion planned for traditional orthognathic approach and requiring bimaxillary orthognathic surgeries in which there will be le fort i osteotomy with maxillary advancement ranging from 2mm to 5 mm in addition to mandibular setback. 2. patients with no signs or symptoms of active tmds. 3. highly motivated patients. exclusion criteria: 1. patients who refused to be included in the research. 2. patients with systemic diseases that may hinder the normal healing process or render the patient not fitting for general anaesthesia. 3. patients with intra-bony lesions or infections that may retard the osteotomy healing.

Keywords: orthognathic surgery virtual planning customized titanium plates cutting guides cad/cam
efficacy and safety of agn-199201 in patients with persistent erythema associated with rosacea

Conditions: Erythema; Rosacea

Summary: this study will evaluate the safety and efficacy of agn-199201 once daily compared to vehicle for the treatment of persistent moderate to severe facial erythema associated with rosacea.


Eligibility criteria:
inclusion criteria: -moderate to severe persistent facial erythema associated with rosacea. exclusion criteria: * greater than 3 inflammatory lesions on the face * current treatment with monoamine oxidase (mao) inhibitors * raynaud's syndrome, narrow angle glaucoma, orthostatic hypotension, scleroderma or sjogren's syndrome.
reducing potentially inappropriate medication prescribing for older patients in the ed

Conditions: Aging

Summary: this research is being conducted to learn which implementation strategy of equipped is most effective to improve prescribing practices of ed providers toward older veterans and determine the factors influencing implementation of this program to reduce the prescribing of pims to older adults upon discharge from the ed. the study has three research aims. the procedures for these research aims are described below: * aim 1 - examining the impact of passive provider feedback vs. active provider feedback through a randomized trial * aim 2 - determination of factors affecting organizational adoption of equipped * aim 3 - micro-costing the active and passive feedback versions of the equipped intervention

enhancing quality of prescribing practices for older adults discharged from the emergency department (equipped is a multi-component program to reduce the prescribing of potentially inappropriate medications (pims) to older adults upon discharge from the emergency department (ed). it has three core components: 1) provider education, 2) electronic health record (ehr)-based clinical decision support (cds) including pharmacy quick order sets to facilitate provider order entry, and 3) provider audit and feedback with peer benchmarking. in order to inform a veterans affairs (va) system-wide approach to improve prescribing safety for older veterans, the investigators will conduct a study to determine best practices for influencing provider prescribing behavior in order to decrease pims prescribed for older veterans at the time of ed discharge. the overall goal of this project is to determine which equipped implementation strategy (active or passive feedback) is most effective to reduce prescribing of pims for older veterans discharged from the ed.

Eligibility criteria:
inclusion criteria: * prescribers at va medical centers that are implementing equipped * members of the equipped implementation team at enrolled sites exclusion criteria: * providers at va medical centers that are not part of the upcoming equipped implementation trial.

Keywords: emergency department potentially inappropriate medications inappropriate prescribing quality improvement veteran health older adults