Kornimate/medical-research-clean huggingface dataset:
an efficacy trial of iron, zinc and vitamin a fortified rice in children in satun, thailand

Conditions: Vitamin A Deficiency; Iron Deficiency; Zinc Deficiency

Summary: iron, zinc and vitamin a deficiencies are particularly common among children and young women in the developing countries of south and southeast asia resulting in important adverse health effects. simultaneous fortification of rice with iron, zinc and vitamin a could be a novel and sustainable approach to control these deficiencies. recently conducted extrusion trials have demonstrated that extruded rice grains containing iron, zinc and vitamin a show acceptable stability during production and storage and good sensory properties. the grains were produced using a twin-screw extruder equipped with a special cutter and a rice shaping die. the fe, zn and vitamin a content of the extruded product is 10 mg, 9 mg and 1050 μg per g of rice, respectively. in this study the investigators plan to test the efficacy of the extruded triple fortified rice in satun, thailand, an area where rice is the staple food. preliminary data from this area show that zinc and vitamin a intakes are low. biochemical indicators have confirmed zinc deficiency and suboptimal vitamin a status in 1/3 of school aged children. the efficacy of the fortified rice will be evaluated in a 9 months, controlled, double-blind intervention trial in 7-12 y-old children. children will be selected from primary schools in satun province based on low serum zinc values as the primary goal is to investigate zn efficacy. as secondary outcome the effect on iron and vitamin a status will be investigated. the children will be randomized into two groups: a control group will receive a daily non-fortified rice lunch meal at school, while the second group will receive a daily rice meal containing the triple fortified rice. the rice meals will be given 5 days a week. at baseline, weight and height will be measured and determination of hemoglobin, serum ferritin, zinc protoporphyrin, serum zinc, serum retinol and c-reactive protein will be done. at mid-point and at 9 months, the baseline measurements will be repeated to judge the efficacy of the triple fortified rice.


Eligibility criteria:
inclusion criteria: * preliminary screening: 650 children of 7-12 y-old children attending the primary school serving a low-income area in muang district , satun.(no exclusion criteria). * efficacy trial: 180-200 children, children with the zn deficiency (serum zinc \< 65, 66 and 70 µg/dl in children \< 10y, male ≥ 10y and female ≥ 10y) exclusion criteria: * children showing severe iron, zinc or vitamin a deficiency. these children will be excluded from the study and treated according to local policies. * significant chronic medical illness, including gastrointestinal, hematological, hepatic or renal disorders. * low school attendance (\<80%).

Keywords: fe deficiency, zn deficiency, vitamin a deficiency
transumbilical versus transvaginal specimen retrieval at minilaparoscopy

Conditions: Postoperative Pain; Patients Satisfaction; Intraoperative Complications; Postoperative Complications

Summary: we hypothesise that pain at minilaparoscopy for gynecologic disease is reduced when transvaginal rather than transumbilical specimen extraction is accomplished. this would be due to the avoidance of a 10-mm port in the umbilicus. visual analogue scale score of post-operative pain will be obtained and patients satisfaction will be asked at the 2-month postoperative visit.


Eligibility criteria:
inclusion criteria: * adnexal mass * benign gynecologic condition * laparoscopicb surgery exclusion criteria: * obliteration of the douglas pouch
hereditary colorectal and associated tumor registry study

Conditions: Lynch Syndrome; FAP; Hereditary Diffuse Gastric Cancer; Juvenile Polyposis Syndrome; Peutz-Jeghers Syndrome

Summary: after informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample. participants will also be asked for their permission for study investigators to access medical records and/or recontact them for updates to their medical and family histories. data and biospecimens will be stored for potential future research projects.


Eligibility criteria:
inclusion criteria: * identified gene mutation * personal history of colorectal cancer diagnosed ≤ 50 * personal history of cancer with tumor studies suggestive of lynch syndrome * personal history of multiple primary tumors associated with a hereditary cancer syndrome (colorectal, uterus, stomach, ovary, small bowel, hepatobiliary tract, transitional cell carcinoma of the renal pelvis/ureter, brain) * personal history of one of the above cancers and a family history of one or more of the above cancers * personal or family history of diffuse gastric cancer * from a known genetic predisposition family * personal history of \> 10 colon adenomas (cumulative over a lifetime) * personal history of any number of hamartomatous polyps * personal history of multiple large (\> 1cm) serrated polyps to right of sigmoid exclusion critera: * individuals under the age of 8 * individuals who cannot travel to pittsburgh for in-person enrollment * individuals who cannot provide informed consent
behavior of children related to numbness after dental local anesthesia

Conditions: Anesthesia, Local; Anesthesia, Dental

Summary: in children, behavior management is critical to the success of pediatric dental procedures. most of the studies on local anesthesia performed in children deal with the question how to avoid or minimize pain during injection. due to the sensation of numbness children scratch the soft tissues and bite lips and tongue. in many cases, this may be kept in children's memory as a "painful experience" and may affect their behavior in the following visit. the purpose of this study is to evaluate children's reactions to the administration of local anesthetic injection in the mandible (mandibular block) and in the maxilla (supraperiosteal infiltration), and to assess their behavior in the following visit related to each type of injection.

children between the ages of 4 to 7, undergoing dental treatment at the department of pediatric dentistry of the hadassah school of dental medicine will participate in the study. all patients should be asa class i with no prior dental treatment who need at least two clinical sessions of similar operative procedures preceded by local anesthetic injection, one in each jaw, none of which due to emergency. subjective and objective evaluation will be performed according to previously validated scales.

Eligibility criteria:
inclusion criteria: * age: 4-7 * behavior: frankel 3-4 * no sedation (premedication) * asa 1 * no dental treatment before * need for similar treatment in the upper and lower jaw * no emergency treatment exclusion criteria: * need of premedication * uneven treatment in each jaw

Keywords: behavior local anesthesia behavior after dental local anesthesia
68ga-n188 pet/ct imaging in malignancy

Conditions: Neoplasms

Summary: the nectin-4 protein belongs to the cell adhesion factors family and has a tissue-specific expression spectrum in normal human tissues. however, nectin-4 is overexpressed in various malignancies, especially those of epithelial origins, such as uroepithelial carcinoma, making nectin-4 a highly specific and significant imaging target for malignancies. \[68ga\]n188, a novel molecular probe of pet imaging agent that targets nectin-4, can be used in the diagnosis and research of a wide variety of nectin-4 high-expression malignancies, including bladder cancer.


Eligibility criteria:
inclusion criteria: * patients with confirmed or suspected cancer; * 18f-fdg pet/ct within 1 week; * signed written informed consent. exclusion criteria: * pregnant and lactating women; * female patients plan to become pregnant within 6 months.

Keywords: [68ga]n188 nectin-4 pet/ct neoplasms
multipoint pacing mapping study

Conditions: Heart Failure

Summary: the purpose of this study is to characterize left ventricular acute hemodynamic and electrical responses during cardiac resynchronization therapy (crt) with different multipoint pacing (mpp) settings, and assess the relationship between electrical activation patterns and hemodynamic measurements during these pacing settings.


Eligibility criteria:
inclusion criteria: * be scheduled to undergo or have received within the past 30 days an implant of a sjm (st. jude medical) mpp crt-d system with approved standard indication by esc (european society of cardiology) / ehra (european heart rhythm association) guidelines * have the ability to provide informed consent for study participation and be willing and able to comply with the clinical investigation plan (cip) described evaluations and follow-up schedule * be in sinus rhythm exclusion criteria: * complete av (atrioventricular) block * permanent atrial fibrillation * have a recent myocardial infarction within 40 days prior to enrollment * have undergone cardiac surgery or coronary revascularization procedure within 3 months prior to enrollment or be scheduled for such procedures in the following 7 months * have had a recent cva (cerebrovascular accident) or tia (transient ischemic attack) within 3 months prior to enrollment * have had intravenous inotropic support in the last 30 days * be less than 18 years of age * be pregnant or plan to become pregnant over the next 7 months * have significant peripheral vascular disease * have lv thrombus * significant aortic valve disease or replacement * mitral valvular disease * contraindicated for gadolinium contrast agent
evaluation of apnea tolerance in bariatric patients following rapid-sequence induction of anesthesia

Conditions: General Surgery

Summary: the purpose of this study is to compare the effect of the 25° head-up position versus the 55° head-up position on tolerable apneic time (tat) in bariatric patients scheduled for laparoscopic adjustable gastric band surgery following maximum preoxygenation and rapid-sequence induction (rsi) of anesthesia.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status ii-iii patients * body mass index (bmi) of 40-60 * scheduled for an elective laparoscopic adjustable gastric band surgery exclusion criteria: * patients with abnormalities of the upper airway that require awake tracheal intubation * asthma * chronic obstructive pulmonary disease * pregnant patients

Keywords: tolerable apneic time bariatric surgery gastric band surgery intubation
community-based hepatitis b interventions for hmong adults

Conditions: Liver Cancer

Summary: the purpose of this study is to design an intervention to increase hepatitis b (hbv) screening among hmong americans.

the investigators will design an intervention to measure the baseline proportion of hmong adults (ages 18-64) that have been serologically tested for hepatitis b. investigators will work with lay health workers to promote serologically testing for hepatitis b and increase knowledge of hepatitis b among hmong adults. the effectiveness of the lay health worker intervention will be evaluated by conducting a randomized, controlled trial among hmong adults aged 18-64 not previously tested for hepatitis b. the primary hypothesis is that the proportion of hmong adults, ages 18-64 reporting serologically testing for hepatitis b at post-test will be significantly greater in the intervention group than in the control group. secondary hypotheses are: there will be greater increases in knowledge of hepatitis b and liver cancer in the intervention group than in the control group. participants with greater knowledge of hepatitis b and liver cancer at post-test will be more likely to be serologically tested for hepatitis b.

Eligibility criteria:
inclusion criteria: * ages 18-64 years * hmong ancestry * never have been tested for hepatitis b exclusion criteria: * children under the age of 18 years * adults over the age of 64 years * non-hmong ancestry * previous testing of hepatitis b

Keywords: asian american health cancer hepatitis hepatitis b liver cancer
culturally-focused consultation for asian americans and latino americans

Conditions: Depression

Summary: the purpose of this study is to determine if a culturally focused psychiatric (cfp) consultation service can improve depressive symptoms and increase diagnosis and treatment of depression in asian american and latino american primary care patients at the massachusetts general hospital.

this study's aim is to determine if a culturally focused mental health consultation will help latino and asian americans who are experiencing sadness, stress, or other symptoms of depression. eligible adults must already have a primary care physician at massachusetts general hospital. in this study, patients will be randomly assigned, like the flip of a coin, to receive the culturally focused intervention or treatment as usual. those who receive the intervention will have three sessions with study personnel, during which they will generally discuss and learn techniques for dealing with their mental health. those who receive treatment as usual, meaning the regular care they receive through their primary care practice, will have two sessions with study personnel during which they will generally discuss their mental health. all study visits and patient materials are provided in patients' language of choice - english, spanish, mandarin, cantonese, or vietnamese. all patients will be compensated for completing study visits. about half of the study patients in both arms will also be invited to participate in optional qualitative interviews, in which they will be asked questions about their expectations for the research study and their ideas for improving culturally sensitive mental health services. in addition, a small sample of asian american patients who did not participate in the study but who have pcps at the sites where the study was conducted will be contacted for a qualitative interview. this interview will address reasons why asian american recruitment for the study was so challenging.

Eligibility criteria:
inclusion criteria: * capable of giving informed consent * adults 18 years of age or older * members of either asian american or latino american minority groups * currently experiencing depressive symptoms exclusion criteria: * active unstable, untreated psychiatric illness precluding participation in study
acupuncture for chemical therapy induced nausea and vomiting

Conditions: Chemotherapy-induced Nausea and Vomiting

Summary: this is an expertise-based randomized controlled trial. the hypothesis of this study is that the differences in expertise of acupuncturist may impact clinical effect. in this study, patients will be randomized to 4 group, receiving the treatment from senior acupuncturist, junior acupuncturist, junior acupuncturist by only acupuncture neiguan(p6), or not receive the acupuncture. all patients receive the basic cisplatin chemotherapy. the duration of treatment is from the first day receiving cisplatin until two days after cisplatin on each group. nci and rhode scale will be used to measure the control of nausea and vomiting.

this is an expertise-based randomized controlled trial. the hypothesis of this study is that the differences in expertise of acupuncturist may impact clinical effect. in this study, 102 patients will be randomly divided into 4 groups which separately receiving the treatment from senior acupuncturist(clinical experience\> 15 years, considered in this trial as highly expertised), junior acupuncturist(clinical experience\< 5 years, considered in this trial as lower expertised), junior acupuncturist only acupuncture neiguan(p6), or not receiving the acupuncture. all participants receive the cisplatin-based chemotherapy and 5-ht3 as antiemetic treatment will be included. acupuncture treatments are given once daily, the duration of treatment is from the first day receiving cisplatin until two days after cisplatin. nci and rhode scale will be used to measure the control of nausea and vomiting. only outcome assessors are blinded. generalized estimating equations will be used to compare the effects among groups.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cancer * must receive cancer chemotherapy containing cisplatin * use 5-th receptor antagonists as an antiemetic drug in the chemotherapy duration exclusion criteria: * concurrent neoplasms or illness that induces nausea independent of chemotherapy * received acupuncture treatments for other conditions less than 4 weeks before chemotherapy treatment * severe infection * severe heart, liver, kidney and brain diseases * cardiac pacemaker * radiotherapy or hormone therapy during chemotherapy treatments

Keywords: acupuncture expertise-based randomized controlled trial nausea vomiting cancer
determination of the best positive end-expiratory pressure (peep)

Conditions: Positive Expiratory Pressure; Acute Respiratory Distress Syndrome

Summary: determination of the best positive end-expiratory pressure (peep) based on oxygenation or driving pressure in patients with acute respiratory distress syndrome (ards) after cardiothoracic surgery the use of a positive end-expiratory pressure in acute respiratory distress syndrome is obvious in ards management. on the one hand it serves to fight against the reduction of functional residual capacity (frc) and enable the limitation of hypoxia; and on the other hand it allows the limitation of "opening/closing" lesions in pulmonary alveoli which lead to increase "bio trauma". however elevated peep has harmful effect such as hemodynamic effect on the right ventricle and distension on healthy part of the lung.other adverse effects are: decreasing cardiac output, increased risk of barotrauma, and the interference with assessment of hemodynamic pressures. ideally the adjustment of peep level must be done by taking into account each patient characteristic. peep titration based on blood gas analysis is one of the most used techniques by physicians. current guidelines for lung-protective ventilation in patients with acute respiratory distress syndrome (ards) suggest the use of low tidal volumes (vt), set according to ideal body weight (ibw) of the patient, and higher levels of positive end-expiratory pressure (peep) to limit ventilator-induced lung injury (vili). however, recent studies have shown that ards patients who are ventilated according to these guidelines may still be exposed to forces that can induce or aggravate lung injury. driving pressure (dp) is the difference between the airway pressure at the end of inspiration (plateau pressure, ppl) and peep. driving pressure may be a valuable tool to set peep. independent of the strategy used to titrate peep, changes in peep levels should consider the impact on driving pressure, besides other variables such as gas exchange and hemodynamics. a decrease in driving pressure after increasing peep will necessarily reflect recruitment and a decrease in cyclic strain. on the contrary, an increase in driving pressure will suggest a non-recruitable lung, in which overdistension prevails over recruitment. the main purposes of this study are to assess the optimal peep based on the best driving pressure or the best oxygenation.


Eligibility criteria:
inclusion criteria: * all patients admitted for intensive care with acute respiratory distress syndrome intubated according to the criteria of the berlin consensus exclusion criteria: * undrained pneumothoraces * hemodynamic instability defined by increased need of vasopressors and / or an systolic arterial pressure below 90 mmhg * hypovolemic shock * bronchopleural fistula * high intracranial pressure
comparison of botulinum toxin injections in forearm flexor plus extensor muscles vs. flexor muscles alone for treatment of essential hand tremor(flex-d et)

Conditions: Essential Tremor

Summary: to compare the efficacy of botulinum toxin (bont) injections in forearm flexors plus extensor muscles versus flexors alone for the treatment of essential hand tremor (et).

the investigators propose a pilot, single center, double blind, randomized, parallel, placebo controlled trial comparing 2 (bont) injection patterns for treatment of moderate to severe essential tremor. the investigators will recruit 20 patients with (et).

Eligibility criteria:
inclusion criteria: 1. age 18 and over, male or female patient with (et) involving at least their dominant hand, as diagnosed by a movement disorders neurologist. 2. having bothersome hand tremor in dominant hand with a hand trs ≥2 3. on stable medications during last 30 days prior to enrollment. exclusion criteria: 1. presence of secondary causes of tremor, such as dystonia and parkinsonism 2. any contraindication to botulinum toxin injections (e.g. motor neuron disease, neuromuscular junction disease, etc.) 3. history of surgical treatment for (et). 4. dementia as defined by dsm-v criteria 5. patients with suboptimally treated depression and significant depressive symptoms as defined by a phq-9 score of ≥15 (phq-9 scores 1-4 minimal depression; 5-9 mild depression; 10-14 moderate depression; 15-19 moderately severe depression; 20-27 severe depression). antidepressant medications, prescribed for depression or anxiety, will be allowed if the patient has been on a stable dose for at least 30 days. 6. patients with suboptimally treated anxiety and significant anxiety symptoms as defined by a gad-7 score of ≥15 (gad-7 scores 0-4: minimal anxiety; 5-9: mild anxiety; 10-14: moderate anxiety; 15-21: severe anxiety). anti-anxiety medications, prescribed for anxiety, will be allowed if the patient has been on a stable dose for at least 30 days. 7. significant renal, hepatic, cardiac and thyroid disease
study to evaluate the performance of a sustained vacuum system

Conditions: Seroma as Procedural Complication; Hematoma Postoperative

Summary: the purpose of this study is to evaluate the performance of the somavac® 100 sustained vacuum system after oncologic resections.


Eligibility criteria:
inclusion criteria: * aged 21 years or older; * undergoing mastectomy (uni or bilateral), axillary node resection, or inguinal node resection; * capable of providing informed consent. exclusion criteria: * pregnant or lactating females; * patients on steroids or other immune modulators known to impact healing; * patients who are likely to not complete the study; * patients who, in the opinion of the investigator, are unlikely to comply with the protocol; * patients who have participated in this trial previously and who were withdrawn; * patients with known allergies to contacting materials (i.e. latex, metal, etc.); * patients who received neoadjuvant chemotherapy or radiotherapy within the last 3 weeks.

Keywords: seroma following procedure healing delayed dehiscence