Kornimate/medical-research-clean huggingface dataset:
voice analysis for monitoring patients with heart failure

Conditions: Heart Failure

Summary: this observational study involves adhf patients at two sites in the united states and germany. after informed consent and screening assessments, participants will perform daily voice recordings during their hospital stay, from admission until discharge. alongside voice data, additional clinical information such as left ventricular ejection fraction, ntpro-bnp levels, and ecg-data will be collected for comprehensive analysis. the study's goal is to identify voice-based indicators of heart failure progression, with the potential to enhance remote monitoring and self-management strategies for heart failure patients.


Eligibility criteria:
inclusion criteria: * clinically diagnosed with acutely decompensated heart failure. * at least 18 years of age. exclusion criteria: * disabling mental diseases (e.g., alzheimer's disease) * clinically diagnosed chronic obstructive pulmonary disease (copd) * treatment in icu or imu * dialysis treatment * previous operations on organs involved in generation of voice (vocal tract, vocal folds, etc.) * neurodegenerative diseases * pregnancy * inability to provide consent
tension type headache, myofascial release therapy , post isometric relaxation technique

Conditions: Neck Pain

Summary: comparative effects of myofascial release therapy and post isometric relaxation technique on pain and functional disability in patients with tension-type headache

tension-type headache (tth) is the most common type of primary headache, typically presenting as a bilateral, non-throbbing headache with mild to moderate intensity. patients with tension-type headache often report band-like tightness and increased tenderness of the pericranial muscles. use of myofascial release technique and post isometric relaxation technique is believed to reduce the pain and improve the functional disability.

Eligibility criteria:
inclusion criteria: * • age range 25-45years14 * both male and females * suffer from tension type headache more than three months * head pain on bilateral location * may suffer from photophobia, phonophobia * pericranial tiredness * not getting enough exercise or sleep exclusion criteria: * • history of teeth clenching or grinding * cardiovascular disease * pregnancy * arthritis in the neck * being overweight

Keywords: myofascial release therapy
residual neuromuscular blockade in pediatric anesthesia

Conditions: Residual Neuromuscular Blockade

Summary: residual neuromuscular blockade (rnb) is frequent and it is associated with postoperative morbidity and mortality. the incidence of the rnb in pediatric anesthesia is currently not known. the aim of this prospective observational cohort study is to evaluate the early rnb just before extubation and late rnb at the time of arrival to postanesthetic care unit (pacu).

residual neuromuscular blockade (rnb) is frequent and it is associated with negative impact on postoperative morbidity and mortality. the incidence of the rnb in adult is well described, however in pediatric subpopulation it is currently not known. the aim of this prospective observational cohort study is to evaluate the early rnb just before extubation and late rnb at the time of arrival to postanesthetic care unit (pacu). in the trial will be enrolled all pediatric patients (28 weeks of age and older - 19 years old) whom will be administered neuromuscular blocking agent during anesthesia. the demographic data will be collected including: age, weight, type of surgery, asa status. the anesthesia management will be described including: airway management, type and cumulative dose of neuromuscular blocking agent (nmba) and time and dose of the last administered bolus of nmba. the residual neuromuscular blockade will be measured according to the standards: tof watch accelerometry at the moment prior to extubation (two measurements) in tof mode and at the arrival to postanesthetic care unit (pacu) (two measurements) in tof mode.

Eligibility criteria:
inclusion criteria: * paediatric patients undergoing surgery with neuromuscular blocking agents were administered with the age limits exclusion criteria: * weight under 3000 grams * neuromuscular disease * haemodynamic impairment (vasopressor need) * planned postoperative mechanical ventilation

Keywords: residual neuromuscular blockade
effects of short wave diathermy added on dextrose prolotherapy injections in osteoarthritis of the knee

Conditions: Knee Osteoarthritis

Summary: goal: to show the effects of short wave diathermy added on prolotherapy injections in osteoarthritis of the knee on pain, physical functioning and quality of life. material and methods: 63 patients with osteoarthritis of the knee with kellgren-lawrence (k-l) class 2 or 3 were included in the study. patients were randomized to two grous, first being dextrose prolotherapy+ short wave diathermy(swd), and second being dextrose prolotherapy with sham swd. patients were injected with dextrose prolotherapy solutions in the beginning, 3rd and 6th week of the study, for a total of 3 times, and took 20 minutes of swd after injection(true or sham). western ontorio and mcmaster universities osteoarthritis index (womac), visual analogous scale for pain(vas) and short form health survey (sf-36)were applied before, after(6th week) and at the 3rd month of treatment.


Eligibility criteria:
inclusion criteria: * inclusion criteria were being between 45 and 75 years old, knee pain of 3 months or longer duration, and having oa of the knee compatible with kellgren-lawrance class 2 or 3 exclusion criteria: * patients using analgesics other than acetaminophen, having pregnancy, diabetes mellitus, infectious or inflammatory arthritis, hemophilia, knee prosthesis, history of knee injections in last 3 months or anticoagulant use, allergy to ingredients of the solutions, having cardiac pacemaker or other device, or metallic implants were exluded from the study.

Keywords: knee osteoarthritis prolotherapy hypertonic dextrose solution injections short-wave diathermy
cryaoablation assisted partial nephrectomy a non ischemic approach

Conditions: Kidney Neoplasms

Summary: patients with renal masses eligible to partial nephrectomy often require arterial ischemia to control or prevent blood loss during this surgical procedure. this study aims to determine the safety and efficacy of renal cryoablation at the tumor bed, as a substitute measure or technique vs total or selective arterial renal ischemia.

nephron sparring surgery has emerged as the procedure of choice for most patients with renal tumors that are \>2 cm and harbor a greater than 50% exophitic component. in order to decrease blood loss surgeons may: 1- interrupt blood flow to the kidney, completely or selectively; 2-use diuretics such as mannitol to dehydrate the kidney; 3-ice externally the kidney - in open procedures - to decrease metabolism during ischemia. the emergence of robotic surgery triggered a shift in the the surgical approach to partial nephrectomy and is commonly employed. a fundamental drawback of this technique is represented on the lack of cold ischemia. however, warm ischemia is commonly employed and requires dissection of the renal pedicle, which by itself puts the kidney at risk of loss.

Eligibility criteria:
inclusion criteria: * patients with ages between 45-90-year-old. * renal tumor ≤ 7 cm in the greatest extension, \>50% exophitic. exclusion criteria: * prior renal surgery * m1 disease
effects of a computer game on activity choices

Conditions: Overweight

Summary: the study seeks to discover whether peer rejection increases the value of food relative to peer interaction in overweight individuals. after playing a computer game that randomly simulates peer rejection or peer acceptance, participants will play another computer game that will assess the value of food and social interactions. overweight individuals may be more likely to resort to food in moments of distress and less likely to choose to interact with a peer to reestablish their sense of belongingness.


Eligibility criteria:
inclusion criteria: * adults ages 18-50 * adults with a bmi greater than or equal to 18.5 * adults must report at least a moderate liking of study foods used exclusion criteria: * adults should have no psychopathology * adults should have no developmental disabilities * adults should have no cold or upper respiratory distress that could influence their activities * adults should have not be taking medications that could affect their food intake * adults should have no dietary restrictions * adults should have no food allergies

Keywords: peer rejection obesity amount of food chosen amount of social time chosen
virtual reality versus conventional exercise intradialysis

Conditions: End Stage Renal Disease

Summary: all participants exercised during 16 weeks following a conventional intradialysis exercise program. the last 4 weeks of the study participants were randomized into two different exercise programs intradialysis. one group exercised through a virtual reality exercise adapted specially for patients while receiving hemodialysis treatment. the other group exercised with a conventional exercise program, combining aerobic cycling and strengthening exercises.

the first 16 weeks all participants followed an intradialysis exercise program. the exercise program consisted of strengthening exercises for lower limbs and for the upper limb free of fistula. the exercise program included isotonic exercises for quadriceps, triceps surae, psoas, glutei, and brachial biceps; and isometric exercises for hip adductors and hamstrings. elastic bands were used to apply resistance. progression was achieved from increasing from 1 set of 10 repetitions until 3 sets of 15 repetitions. this first part lasted no more than 30 minutes. the program also included aerobic exercise (cycling) for up to 30 minutes. intensity was adapted through the duration of the study so that the participant felt the exercise from hard to somewhat hard (13 to 15 at the rate of perceived exertion 6 to 20). time and resistance were adapted progressively. the last four weeks of the program participants were randomized into virtual reality exercise or conventional exercise group. the virtual reality exercise group undertook 30 minutes of exercise. after warming up, participants had to play to an adapted 'treasure hunt' game. their legs movements were the players projected into an individual tv that gave them feedback regarding their achievements. the aim of the game was to achieve the higher possible score.they moved to pick up coins and to avoid bombs. an adapted kinect technology was used for the game development.

Eligibility criteria:
inclusion criteria: - patients in hd therapy at least 3 months exclusion criteria: * recent myocardial infarction (within 6 weeks) * unstable angina * malignant arrhythmias * above the knee amputation without replacement * cerebral vascular disease (ictus, transient ischemia) * musculoskeletal and respiratory disorders that can get worse with exercise * impossibility to achieve functional testing

Keywords: exercise hemodialysis virtual reality
ktp laser vs pulsed dye laser for port-wine stains

Conditions: Port-Wine Stain

Summary: to compare the efficacy and safety of 532nm ktp laser and 585 nm pulsed dye laser for treating port-wine stains.

nevus flammeus is a vascular, primarily capillary malformation visible from birth on. in rare cases, it may also affect venous and/or arterial vascular systems of the skin or other organs \[1\]. it occurs in 0.3%-0.5% of the population \[1\], i.e. in about 3-4 out of 1000 newborns, and is thus the most frequent vascular malformation in children. the cause is a permanent dilatation of the capillary vessels, which is caused by a lack of sympathetic nerve fibers or a lower density of the same. first-line therapy of port-wine stains consists of laser treatment with the long-pulsed dye laser \[2\] with a wavelength of 595nm. treatment must be performed at least 10 times at intervals of about 8 weeks and leads to lightening and reduction of lesions. in recent years, problems have often arisen in care of port-wine stain patients because dye lasers often failed due to the instability of technology, resulting in treatment delays. novel long-pulsed ktp lasers may be a sufficient alternative to pulsed dye lasers in treatment of port-wine stains.

Eligibility criteria:
inclusion criteria: * men and women 18 years and older * good general health, no relevant previous diseases * presence of one or more port-wine stains * cognitive ability and willingness to give consent (informed consent) exclusion criteria: * age \< 18 years * pregnant and breastfeeding women * significant open wounds or lesions in the region to be treated * missing consent and/or data protection declarations
effect of home-based peer support on maternal-infant interaction and postpartum depression

Conditions: Postpartum Depression

Summary: the objective of this study is to examine the impact of a home-based peer support intervention for mothers affected by postpartum depression (ppd) and for their infants.

this controlled study will help establish the link between support for maternal caregiving, maternal-infant interaction, infant neuroendocrinology and infant cognitive and social development. the primary hypothesis predicts that home-based peer support will improve maternal-infant interactions. secondary hypotheses predict that home-based peer support will: improve infants' cognitive development; improve infants' social development; decrease average daily salivary cortisol levels in infants; reduce maternal depressive symptomatology; and improve maternal perceptions of social support.

Eligibility criteria:
inclusion criteria: * eligible mothers will be identified as experiencing symptoms of ppd and scores \>12 on the edinburgh postnatal depression scale. * mothers must speak english or french. * mothers will not be excluded for taking anti-depressant or anti-psychotic medication, using other interventions for ppd, or reporting a history of mental illness; * the infant must be full-term, in the care of the mother and between 3 to 6 months of age at initial enrollment. exclusion criteria: * infants who have been admitted to the nicu * infants will be excluded if medicated with corticosteroids
post lumbar radiofrequency neurotomy imaging

Conditions: Facet Joint Pain

Summary: mri imaging post radio frequency ablation procedure for facet arthritis

this study is an imaging study. following a radio frequency ablation procedure for facet arthritis low back pain the patient can join the imaging study. during the study the patient undergo contrast enhanced mri imaging of the lumbar spine once the imaging is done the patient finishes the study

Eligibility criteria:
inclusion criteria: 1. adult male and females, legally able and willing to participate in the study 2. able and willing to complete the research questionnaires and communicate with the investigator and research team 3. patients who are scheduled to have bilateral or unilateral treatment by radiofrequency neurotomy for chronic lumbar pain. exclusion criteria: 1. pregnant or breastfeeding patient 2. patients younger than 18 3. patients unable to understand and complete the research questionnaires in english 4. patient with any contraindication for mri contrast agents - patients with known intolerance or allergies to the mri contrast agent (e.g., gadovist) including advanced kidney disease 5. patients with a pacemaker, implanted defibrillator or internal pacing wires. 6. patient with mechanical heart valve 7. patient with an aneurysm clip 8. patient with eye surgery or injury involving a metallic object 9. patient with ear surgery or implanted device to the ear 10. patient with any implanted electrical, metallic or magnetic device such as implanted neurostimulator, implanted drug infusion pump or bone growth stimulator 11. patient with any kind of prosthesis (eye, ear, penile, limb), or any other metal in your body from surgery or injury 12. patient with vascular clamp, filter, coil or stent 13. pregnant or breast-feeding patient 14. patient with anemia, liver disease or history of mri contrast reaction 15. patient with any known kidney disease, prior kidney surgery or on dialysis 16. patient with hypertension or diabetes that requires medication 17. patient with any metal in or on their body (example: shrapnel, bb's, tattoos, permanent makeup) 18. patients who are claustrophobic or known adverse psychological reactions with previous mri
improving patient-centered care for diabetes in bangladesh through "dynamic integration" of vision care on the demand side

Conditions: Diabetes Mellitus; Diabetic Retinopathy (DR)

Summary: the goal of this clinical trial is to review if there is an increase in participant uptake of diabetes mellitus (dm) and diabetic retinopathy (dr) services and improve the quality of patient-centered diabetic care through the use of automated voice message reminders to sensitize people with dm about the potential for sight loss alongside the provision of free reading glasses. the main questions it aims to answer are: 1. will the proportion of patients defaulting on their scheduled dr and dm appointments be significantly reduced in the group receiving the automated voice messages compared with participants not receiving the messages? 2. what is the cost-effectiveness, measured as total intervention cost per additional patient complying with the suggested exam. researchers will compare the number of participants that received automated voice messages that completed their diabetes or dr exam within 3 weeks of the scheduled date to participants that did not receive the messages.


Eligibility criteria:
inclusion criteria: * diagnosed with dm within the last 6 months * diagnosed with high-risk dr * over 30 years of age * currently treated at the dinajpur diabetes hospital * possess a mobile phone to receive voice messages * willingness to participate in the study exclusion criteria: * other significant causes of vision loss * medical conditions that could impair compliance with follow-up (such as stroke, dementia, etc.) * do not possess a mobile phone to receive voice messages * not willing to participate in the study
expanding rural access: distance delivery of support

Conditions: Breast Cancer; Stress Disorders, Post-Traumatic; Depression

Summary: the major goal of this project is to test the feasibility and acceptability of using videoconferencing to provide support groups led by trained facilitators to rural women with breast cancer in northern california.

women with breast cancer in rural areas are likely exhaust their usual sources of psychosocial support while still facing challenges posed by breast cancer, but are unlikely to have access to professionally-led support groups. in this community-based project, we assessed the feasibility and acceptability of providing support groups to women with breast cancer in a large rural area using videoconferencing and a workbook journal, and we assessed the intervention's potential to reduce distress and increase emotional expression and self-efficacy for coping with cancer. twenty-seven women in the intermountain region of northeastern california participated in 8-session support groups led by an oncology social worker by going to nearby videoconferencing sites. feasibility and acceptability were demonstrated. older as well as younger women were comfortable using videoconferencing and said the groups were valuable because they promoted information sharing and emotional bonds with other women with breast cancer. they emphasized the importance of a professional facilitator and identified advantages of using videoconferencing for support groups. pretest and posttest comparisons showed significant decreases in depression and posttraumatic stress disorder symptoms. the results suggest that the intervention has the potential to provide a valuable service that is not readily available in rural communities.

Eligibility criteria:
inclusion criteria: * 1) has been diagnosed with breast cancer, and 2) is a woman exclusion criteria: * 1) under 21 years of age, and 2) does not speak and read english
online wellness intervention for college students

Conditions: Depression; Anxiety; Well-being

Summary: we are evaluating the effects of an online single-session mental health intervention (the common elements toolbox; comet). to evaluate comet, we are conducting a randomized controlled trial with college students attending american universities. students will be randomized to the comet condition or to a wait-list control condition.


Eligibility criteria:
inclusion criteria: * at least 18 years old and a student at a participating university. access to the internet. exclusion criteria: * cannot have participated in a previous version of comet.
clinical outcomes with electroconvulsive therapy: insights from computational modelling

Conditions: Depression

Summary: this study will generate new information on how to optimise brain targets with ect stimulation.

this study will differentiate the brain regions which are related to the effectiveness of electroconvulsive therapy (ect) as a treatment, from the brain regions associated with memory impairment, with ect stimulation. this will be done by 1) testing effects on memory of 4 different forms of ect, which stimulate the brain differently; 2) in a subset of participants, use computer modelling to assess the pattern of brain stimulation with the 4 forms of ect, and match these results to memory outcomes.

Eligibility criteria:
inclusion criteria: * aged ≥18 years; right-handed * dsm-5 major depressive episode * prescribed with a course of ect exclusion criteria: * diagnosis (as defined by dsm-v) of psychotic disorder (apart from major depressive episode with psychotic features), current drug or alcohol abuse or dependence; * ect treatments in last 3 months from a prior course of ect; * score \<23 on the montreal cognitive assessment battery (moca); * past or current neurological illness or injury, medical illness which may significantly affect neuropsychological function; * inability to give informed consent or comply with study procedures; or * not having worked or studied in an english speaking background (to ensure validity of neuropsychological testing). * not be claustrophobic (if having an mri brain scan). * not have any metal in your head or body (if having an mri brain scan). * likely non response to rul forms of ect, as indicated by past non response to rul ect

Keywords: electroconvulsive therapy computer modelling