Kornimate/medical-research-clean huggingface dataset:
induction of migraine aura with sildenafil

Conditions: Migraine With Aura

Summary: in a double blind placebo-controlled cross-over study the effect of sildenafil on aura and migraine headache induction is tested in patient with migraine with aura.


Eligibility criteria:
inclusion criteria: * migraine with aura * minimum of 2 attacks/year exclusion criteria: * any other type of headache, except tension-type headache \< 4 days per month * history of cardio- or cerebrovascular diseases * hypertension or hypotension * any daily intake of medication, including prophylactic migraine treatment, except oral contraceptives * pregnancy and lactation
the impact of an acute bout of exercise on children's eating behaviors

Conditions: Pediatric Obesity

Summary: the purpose of this project is to examine the effects of an acute bout of exercise on children's energy intake over the course of a day. previous studies in adolescents and adults have shown exercise to be effective in decreasing short-term energy intake, with some variability. individual characteristics such as habitual physical activity and psychological factors may influence the effect of exercise on energy intake, but these factors have yet to be examined. the investigators have assembled a multi-disciplinary team of researchers, with expertise in eating behavior, exercise, psychology, and clinical research in order to examine these questions. first, the investigators will examine the difference in energy intake at lunch, snack, and dinner meals in response to 30 minutes of imposed exercise compared to 30 minutes of rest. second, the investigators will collect objective measures of children's habitual physical activity, child characteristics (body composition, eating behavior traits), and individual responses to the controlled exercise bout. the investigators can then examine both group and individual differences in the energy intake response to exercise. children (ages 9-12) will be tested over the course of three visits. the key outcome will be differences in energy intake in response to exercise vs. rest. secondary outcomes include the influence of differences in habitual physical activity, personal characteristics, and responses to the exercise bout on children's energy intake. the long term goal of this line of research is to understand the mechanisms behind the interaction between exercise and energy intake. the translational potential of this research will be to inform personalized childhood obesity prevention strategies in children at risk for overweight.


Eligibility criteria:
inclusion criteria: * english as a native language * reading at/above grade level * generally healthy * child is "normal weight" below the 85% age- and sex-specific bmi percentile * child has at least one biological parent classified as "overweight" or "obese" (≥ 25 kg/m\^2) * regularly eats breakfast exclusion criteria: * contraindications to exercise testing (as defined by the american college of sports medicine) * medical conditions * psychiatric conditions * participation in competitive sports teams (year-round or more than 3 practices / week) * food allergies or other dietary restrictions
oral cancer screening among nursing home dentists in ohio

Conditions: Head and Neck Cancer

Summary: rationale: learning about oral cancer screening practices, knowledge, and opinions of ohio nursing home dentists may help the study of oral cancer in the future. purpose: this clinical trial is studying oral cancer screening among nursing home dentists in ohio.

objectives: * to develop a comprehensive sample of nursing home dentists in ohio. * to document knowledge of oral cancer detection among these dentists. * to describe opinions of these dentists about oral cancer screening competency. * to describe the current oral cancer screening practices of these dentists. outline: participants are stratified according to geographical location (urban vs rural). a comprehensive sample of nursing home dentists practicing in ohio are contacted through a recruitment letter and are asked to respond to questions regarding oral cancer screening practices, knowledge of oral cancer detection, and opinions about oral cancer screening using a newly developed survey, which is based on parts of an existing, pre-tested instrument (oral cancer prevention and early detection survey).

Eligibility criteria:
disease characteristics: * dentist practicing either full-time or part-time in a nursing home setting in the state of ohio patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: lip and oral cavity cancer oropharyngeal cancer
gastric ultrasound of diabetic and non-diabetic patients following preoperative fasting instructions

Conditions: Diabetes; Diabetes Mellitus; Diabetes Mellitus Type 1; Diabetes Mellitus Type 2

Summary: this study evaluates the amount of fluid remaining in the stomach of diabetic patients after a standard fasting period, and compare it with non-diabetic patients coming for elective surgical procedures.

any surgical procedure carries an inherent risk of pulmonary aspiration. food or liquid from the stomach might be forced back up the throat from where it could enter the lungs (aspiration) resulting in serious complications prolonging the hospital stay or in extreme circumstances death. the risk of this is slightly higher in diabetics when compared to non-diabetics as the emptying of contents from the stomach is slightly delayed. this is why people going for surgery are asked not to eat for a specific time before their surgery. anesthesiologists have recently developed an ultrasound test to determine if there is content in a patient's stomach and how much. this test involves an ultrasound examination of the abdomen and taking some measurements on the ultrasound screen. this study aims to evaluate the amount of fluid remaining in the stomach of diabetic patients after a standard fasting period, and compare it with non-diabetic patients coming for elective surgical procedures. the investigators also aim to find an association between the type and duration of diabetes mellitus with residual gastric volume. episodes of intra-operative regurgitation, vomiting or aspiration will also be documented.

Eligibility criteria:
inclusion criteria: * patients scheduled for elective surgery aged 18 to 85 years * american society of anesthesia physical status classification i to iii * body mass index \< 40 kg/ cm2. exclusion criteria: * pregnancy (currently or within the past 3 months) * previous surgery of the upper gastrointestinal tract * achalasia

Keywords: diabetes diabetes mellitus gastric ultrasound preoperative fasting empty stomach gastric diabetes
real-time computer-aided detection of colonic adenomas with nec wise vision® endoscopy

Conditions: Colorectal Cancer; Adenoma Colon; Polyp of Colon

Summary: this is a prospective, multicenter, randomized study to evaluate the clinical performance of a novel cade device, wise vision® endoscopy system, in patients undergoing high-definition white light (hdwl) colonoscopy for screening or surveillance of colorectal cancer (crc). eligible subjects who meet the study inclusion/exclusion criteria will be randomized in a 1:1 ratio to undergo colonoscopy : * experimental: cade colonoscopy procedure with wise vision® endoscopy (cade group) * control: standard colonoscopy without cade (standard colonoscopy group)

this study aims to evaluate whether nec wise vision® endoscopy enhances the ability to detect mucosal lesions when compared with the current standard-of-care procedure (high-definition white light \[hdwl\] colonoscopy). the cade device, wise vision® endoscopy, contains an artificial intelligence/machine learning (ai/ml) advanced algorithm to aid the endoscopists in detection of colonic lesions. this study plans to enrol 830 subjects aged ≥ 45 years and \< 75 years, who are scheduled for screening or surveillance colonoscopy. after review of the inclusion and exclusion criteria, eligible subjects will be randomized in a 1:1 ratio to receive either computer-aided colonoscopy (cade group) or standard colonoscopy without cade (standard colonoscopy group). all adenomas, that are identified during the colonoscopies, will be removed and biopsied as per standard clinical practice to assess adenoma miss rate, polyp miss rate, adenomas per colonoscopy and other endpoints.

Eligibility criteria:
inclusion criteria: * patient is presenting to the endoscopy unit for colon cancer screening or surveillance colonoscopy. * signed informed consent exclusion criteria: 1. contraindications to colonoscopy 2. colonoscopy within the previous three (3) years 3. high-risk indications for colonoscopy 4. antithrombotic therapy that cannot be stopped, precluding polyp resection 5. inflammatory bowel disease 6. referred for endoscopic mucosal resection (emr) 7. familial adenomatous polyposis syndrome or serrated polyposis syndrome 8. pregnant or planning a pregnancy during the study period

Keywords: screening artificial intelligence
the comparison of the efficacy of gingival unit graft with connective tissue graft in root coverage

Conditions: Gingival Recession; Periodontal Diseases

Summary: the purpose of the study is to compare the clinical effectiveness of gingival unit graft (gug) and connective tissues graft (ctg) in miller's class i and ii gingival recession.

patients who accept the study have provided information about the study and required a written informed consent form. the clinical effectiveness of two different periodontal surgical techniques (gingival unit graft and connective tissue graft) in gingival recessions will be evaluated. periodontal measurements (gingival recession, keratinized gingiva height) and patient-reported outcomes (intra and post-operative pain, patient satisfaction and hypersensitivity) are defined.

Eligibility criteria:
inclusion criteria: * systemic healthy individuals * presence miller's class i and ii gingival recession in the anterior and premolar teeth exclusion criteria: * age \<18 years * pregnancy * lactation * any cardiovascular, renal or hepatic conditions * history of periodontal surgery * tooth mobility * presence of probing depth \>3 mm and caries or restorations in the teeth undergoing treatment
alveolar recruitment maneuvers on reduction of lung atelectasis in bariatric surgery by using lung ultrasound score

Conditions: Alveolar Recruitment Maneuvers; Atelectasis; Bariatric Surgery

Summary: the study aims to compare the staircase alveolar recruitment maneuver with peep titration versus sustained inflation alveolar recruitment maneuver by using lung ultrasound score as an indicator of improving lung atelectasis in bariatric surgery

weight loss surgery, often known as bariatric surgery, is an effective obesity treatment. most people undergoing such surgery may show an improvement in, or the resolution of, conditions such as diabetes, dyslipidemia, hypertension, and obstructive sleep apnea. currently, there is no standard ventilation strategy has been established for obese patients. however, there is some evidence that recruitment maneuvers (rm) combined with protective lung ventilation strategy improve oxygenation and compliance compared to other strategies. alveolar recruitment maneuver refers to the periodic hyperinflation of the lungs that has been utilized to open up the lung and keep the lung open in anesthetized patients. the use of recruitment maneuvers has been shown to reduce the incidence and extent of atelectasis during general anesthesia by different methods. lung ultrasonography is considered a useful tool in perioperative care. recent research showed that lung ultrasound could assess lung aeration and diagnose anesthesia-induced atelectasis accurately in the perioperative period by measuring the extent of atelectasis by the scoring system; also, the response to recruitment manoeuver for each patient can be evaluated easily. thus, it has great potential as a bedside non-invasive, sensitive tool for guiding effective recruitment manoeuvers to reduce the formation of pulmonary atelectasis in the surgical setting

Eligibility criteria:
inclusion criteria: * adult morbidly obese patients (body mass index \< 40kg / m2 or body mass index \< 35kg / m2 with obesity-related comorbidities such as hypertension, diabetes, and sleep apnea) * undergo elective bariatric laparoscopic surgery with an expected duration of at least one hour under general anesthesia. exclusion criteria: * patient refusal to participate in the study. * patients with a previous history of thoracic surgery. * patients with a history of chest disease (copd, emphysema, or pneumothorax). * patients with abnormal pre-operative chest radiographs such as pneumonia, pleural effusion. * patients with heart failure or impending failure. * patients with known hypovolemia. * patients with increased intracranial pressure.
comparative study of ologen collagen matrix versus mitomycin-c in glaucoma filtering surgery

Conditions: Glaucoma

Summary: the objective of this prospective randomised study is to compare the efficacy and safety of ologen cm (collagen matrix) and mitomycin-c (mmc) as adjuncts to filtration surgery in uncontrolled treated glaucoma cases, the efficacy being the primary objective and the safety being the secondary.

"ologen ® cm" is a biodegradable collagen matrix. to prevent episcleral fibrosis and subconjunctival scarring thay may result in the surgical failure in trabeculectomy, its sporous matrix modulates the migrations and proliferations of fibroblasts to create a vascular and long-lasting bleb without the adverse effects, such as avascular thin bleb wall, bleb leak, hypotony, and inflammations, potentially caused by the regeneration suppression effects upon the use of cytotoxic agents as anti-fibrotic agents, such as mmc (mitomycin-c)in the study. results of ologen cm studies have been published at conferences and published in peer-reviewed journals; ologen cm is approved in europe as an aid for tissue repair, and by the fda in the us as an adjunct in wound management(k080868). in general, over 6,000 ologen cm have been implanted worldwide during the past two years with good results and excellent safety profile. the clinical trial is a phase-iv post-marketing fda approved device study designed as open-label, randomised, parallel, and comparative. 128 patients at 8 sites are anticipated to be recruited according to the enrollment criteria, while randomisation will be assigned by a sealed envelope system after the patient has signed consent. trabeculectomy is performed thereafter with either mmc or ologen cm applications as described in the protocol with postoperative parameters to be measured and analysed with non-parametric tests(chi-square, fisher's exact, wilcoxon, and mann-whitney tests) as well as kaplan-meier survival models.

Eligibility criteria:
inclusion criteria: * age \> 30 years (inclusive) * uncontrolled treated glaucoma requiring trabeculectomy * subject must be able and willing to cooperate with investigation plan * subject must be able and willing to complete postoperative follow-up requirements * subject must be willing to sign informed consent form exclusion criteria: * known allergic reaction to mmc or porcine collagen * neovascular, uveitic, aphakic glaucoma, previous incisional glaucoma surgery * prior cataract unless clear corneal incision * previous conjunctival or strabismus surgery * participation in an investigational study during 30 days prior to trabeculectomy * ocular infection within 14 days prior to trabeculectomy * pregnant or breast-feeding women

Keywords: ologen collagen matrix mitomycin-c trabeculectomy glaucoma filtering surgery
the effect of dry needling with electrical stimulation on individuals with restless legs syndrome

Conditions: Neck Pain

Summary: the purpose of this study is to examine the effects of dry needling with electrical stimulation (dnes) on sleep quality, symptom severity, and function in individuals with restless legs syndrome.


Eligibility criteria:
inclusion criteria: * age 18-75 years * clinical diagnosis of restless legs syndrome exclusion criteria: * active cancer diagnoses * neuropathic pain (e.g., lumbosacral radiculopathy and/or diabetic neuropathy), * pregnancy * immunocompromised disease (e.g., hiv, aids, lupus) * insufficient english-language skills to complete all questionnaires * inability to maintain treatment positions * contraindications to dry needling:35,36 * presence of needle phobia * history of abnormal reaction to needling or injection * history of bleeding disorder
safety & efficacy of a combination niacin er/simvastatin in patients with dyslipidemia: a dose-ranging study - seacoast

Conditions: Hypercholesterolemia

Summary: the purpose of this study is to compare the effectiveness and safety of different doses of niacin er/simvastatin (ns), in subjects with elevated fat levels in their blood (dyslipidemia).

the purpose of this study is to compare the efficacy and safety of different doses of niacin er/simvastatin (ns), in subjects with elevated fat levels in their blood (dyslipidemia).

Eligibility criteria:
inclusion criteria: * patient has primary type ii hyperlipidemia or mixed dyslipidemia * if the patient is currently taking anti-dyslipidemic medications other than zocor, he/she is willing to withdraw from these medications * reasonable compliance with a standard cholesterol-lowering diet for a minimum of 4 weeks prior to screening and for the duration of the study. * ldl-c levels and/or non hdl-c levels above normal for patients this study will be conducted both in the usa and internationally. exclusion criteria: * patient has an allergy, hypersensitivity, or intolerance to niacin, statins, or their derivatives * hba1c ≥ 9% in diabetic patients

Keywords: dyslipidemia high blood cholesterol coronary heart disease hypertension national cholesterol education program adult treatment panel iii niacin simvastatin diabetes peripheral vascular disease cerebrovascular disease stroke high-density lipoprotein cholesterol hydroxymethyl glutaryl coenzyme a high-sensitivity c-reactive protein low-density lipoprotein cholesterol lipoprotein (a) lipoprotein a-i total cholesterol triglycerides
safety and efficacy of galvus in elderly type 2 diabetes patients

Conditions: Type 2 Diabetes Mellitus

Summary: this study will evaluate the efficacy and safety of vildagliptin 50 mg bid in elderly patients with type 2 diabetes mellitus (t2dm).


Eligibility criteria:
inclusion criteria: * age: ≥ 70 years inclusive at visit 1. * patients with a confirmed diagnosis of t2dm * hba1c of ≥ 7% and ≤10.0% by central laboratory at visit 1 and assessed by the investigator to be inadequately controlled * body mass index (bmi) in the range of 19-45kg/m2 exclusion criteria: * fpg ≥ 270 mg/dl (≥ 15.0 mmol/l) * previous or current participation in any vildagliptin clinical study. * history of hypersensitivity to dpp-4 inhibitors. * concurrent medical condition that may interfere with the interpretation of efficacy and safety data during the study. * donation of blood or significant blood loss equaling to at least one unit of blood within the past 2 weeks of start of study or a blood transfusion within the past 12 weeks or planned regular transfusions during the study period other protocol-defined inclusion/exclusion criteria may apply

Keywords: type 2 diabetes mellitus, vildagliptin, elderly patients
national cohort of children born to hiv-positive mothers

Conditions: Mother to Child Transmission of HIV

Summary: the purpose of this study is to provide a surveillance system to monitor changes in the rate of mother to child hiv transmission and preventive practices in france and especially to identify the occurrence of toxicity in children exposed perinatally to antiretroviral drugs.

the goal of the co11 national cohort is to provide with co1 a wider surveillance system to monitor changes in the rate of mother to child transmission and preventive practices in france and especially to identify the occurrence of toxicity in children exposed perinatally to antiretroviral drugs. the co11 epf enrolle hiv infected women who delivery in maternity generally smaller than co1 maternity (15 sites in paris area, 35 in mainland france and 4 in the dom). maternal clinical, biological and therapeutic data before and during pregnancy were collected at delivery, with simplified questionnaires. the children are examined clinically and biologically at birth, 6, 12 and 24 months.

Eligibility criteria:
inclusion criteria: * pregnant women \>= 18 years * infected with hiv1 and/or hiv2 exclusion criteria: * guardianship or judicial or administrative detention

Keywords: hiv pregnancy prevention of mother-to-child transmission
initiate plus (initiation of insulin to reach a1c target) study

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in the united states of america (usa). the purpose of this study is to compare the effectiveness and safety of a biphasic insulin aspart standard titration regimen when coupled with dietary intervention to standard titration without dietary intervention.


Eligibility criteria:
inclusion criteria: * type 2 diabetes
korean stroke cohort for functioning and rehabilitation

Conditions: Stroke; Disability; Function; Rehabilitation; Burden

Summary: korean stroke cohort for functioning and rehabilitation (kosco) is a large, multi-centre prospective cohort study for all acute first-ever stroke patients admitted to participating hospitals in nine distinct areas of korea. this study is designed as a 10-year, longitudinal follow-up investigating the residual disabilities, activity limitations, and quality of life issues arising in patients suffering from first-ever stroke. the main objectives of this study are to identify the factors that influence residual disability and long-term quality of life. the secondary objectives of this study are to determine the risk of mortality and recurrent vascular events in patients with acute first-ever stroke. investigators will investigate longitudinal health behaviors and patterns of healthcare utilization, including stroke rehabilitation care. investigators will also investigate the long-term health status, mood, and quality of life in stroke patient caregivers. in addition, investigators will identify baseline and ongoing characteristics that are associated with secondary outcomes.


Eligibility criteria:
inclusion criteria: 1. first-ever acute stroke (ischemic stroke or intracerebral hemorrhage) with corresponding lesion and/or evidence of acute arterial occlusion on ct (a)- or mri/a-scan. 2. age ≥ 19 years at onset of stroke. 3. onset of symptoms within seven days prior to inclusion. exclusion criteria: 1. transient ischemic attack. 2. history of stroke. 3. traumatic intracerebral hemorrhage. 4. not korean.