Kornimate/medical-research-clean huggingface dataset:
estimating apnea phenotypes from polysomnography: oxygen

Conditions: Sleep Apnea

Summary: this study seeks to employ advanced methods to estimate the individual factors contributing to sleep apnea from standard recordings made during routine clinical sleep studies. this study focuses on breathing control or "loop gain" as one of the factors contributing to sleep apnea. increased levels of oxygen in the air is known to make breathing more stable by lowering "loop gain". here, our goal is to use a new method capable of detecting a reduction in loop gain with oxygen. the investigators also aim to test whether a high loop gain measured at baseline/placebo predicts a greater improvement in sleep apnea with oxygen therapy.

in a single-blinded randomized crossover study, inspired oxygen/air (40%/21%) is delivered on two separate nights. loop gain is measured from routine polysomnography using a novel mathematical method. a value of loop gain \>1 reflects unstable breathing, and a value less than but approaching 1 denotes a system more prone to oscillate. loop gain is measured as the changes in ventilatory drive/effort that arises subsequent to changes in ventilation (e.g. due to obstructive apnea). a simple chemoreflex model (gain, time constant, delay) is fit to surrogate ventilation data (derived from airflow) during sleep. the best model is one that best matches the elevated ventilatory drive (measured as ventilation in the absence of airflow obstruction) based on the prior apneic/hypopneic fall in ventilation. loop gain is calculated from this model. we aim to use loop gain measured on and off oxygen to determine whether a strong response (reduction in apnea severity) can be predicted by a higher loop gain (in the sham arm) using our method. we also assessed whether assessing upper airway anatomy/collapsibility, dilator muscle responsiveness, and the arousal threshold helped to predict responses to treatment.

Eligibility criteria:
inclusion criteria: * apnea/hypopnea index \>20 events per hour * age 20-79 years exclusion criteria: * copd with desaturation (resting spo2\<96%) * use of respiratory stimulants or depressants * pregnancy
magnesium sulphate for attenuation of hemodynamic pressor response after myfield's clamp application

Conditions: Supratentorial Brain Tumor

Summary: use of mayfield skull clamp during craniotomies; results in a sharp and intense noxious stimulus which results in a severe hemodynamic pressor response. many strategies have been reported to blunt this undesirable pressor effect. this prospective, double blind, and randomized study is the first to evaluate the effect of mgso4 on attenuation of hemodynamic pressor activity after head clamp application during craniotomies.

background: use of mayfield skull clamp during craniotomies; results in a sharp and intense noxious stimulus which results in a severe hemodynamic pressor response. many strategies have been reported to blunt this undesirable pressor effect. this prospective, double blind, and randomized study is the first to evaluate the effect of mgso4 on attenuation of hemodynamic pressor activity after head clamp application during craniotomies. methods: this randomized, double blind, and prospective study was done in neurosurgical department at elsahel teaching hospital in cairo from february 2016 till august 2017. all adult patients aged from 18 to 60 years of both genders, asa physical status i and ii scheduled for craniotomies were assessed to enter this study. seventy one patients were assessed preoperatively, sixty of them were enrolled and assigned in two groups (n=30 each). group m received 50 mg/kg mgso4 in 100 ml 0.9 sodium chloride 15 minutes prior to anesthesia induction over 15 minutes. group s received 100ml 0.9% sodium chloride over the same period with the same rate.mean hr was recorded as a primary outcome , meanwhile; map and the need for a bolus dose of fentanyl was considered a secondary outcome.

Eligibility criteria:
inclusion criteria: * all adult patients aged from 18 to 60 years * of both genders * asa physical status i and ii * scheduled for craniotomies exclusion criteria: * history of mgso4 consumption or allergy * renal disease * hepatic or endocrine disorder * cardiovascular dysfunction * calcium channel blocker intake * drug abuse were excluded from this study.

Keywords: mgso4, mayfield clamp, pressor effect
safety and efficacy of balloon sinuplasty in pediatric sinusitis

Conditions: Chronic Sinusitis

Summary: a non-randomized, multi-center, prospective, clinical study intended to evaluate the safety and efficacy of balloon sinuplasty devices in pediatric patients with longstanding sinusitis following failed medical management.


Eligibility criteria:
inclusion criteria: 1. age \> 2 and \< 18 years 2. both male and female patients eligible 3. planned surgical intervention (i.e. endoscopic sinus surgery, adenoidectomy, sinus irrigation for obtaining a culture) recommended by pi, consented to by patient's legal guardian) 4. longstanding sinusitis: \>3 mo symptoms or 6 episodes/yr and failed 2 courses antibiotics followed by positive ct scan exclusion criteria: 1. extensive previous sinonasal surgery in target ostia 2. cystic fibrosis 3. extensive sinonasal osteoneogenesis 4. sinonasal tumors or obstructive lesions 5. history of facial trauma that distorts sinus anatomy and precludes access to the sinus ostium 6. ciliary dysfunction 7. for female patients of childbearing age: the patient is either pregnant or lactating
effect of different centrifuge values on saliva high sensitive c-reactive protein (hs-crp) levels in individuals with different smoking amounts

Conditions: Smoking

Summary: the purpose of this study; in periodontally healthy individuals, high sensitive c-reactive protein (hs-crp) levels of non-smokers, smokers of less than 10 cigarettes per day and smokers of more than 10 cigarettes per day were measured at 15 rpm-10 min, 10 centrifuge values, which are frequently used in saliva studies. to determine the levels in saliva samples as a result of rpm-10 min and 10 rpm 6 min centrifugations and to determine the values at which a cytokine of this molecular weight should be centrifuged and to examine the possible correlation between these values and the clinical parameters of the amount of smoking. materials and methods: saliva samples were collected from 90 systemically healthy individuals who were non-smokers (n, n=30), light smokers \ 10 cigarettes per day (h, n=20). samples were taken. full-mouth clinical periodontal measurements, including probing depth (pd), clinical attachment level (cal), bleeding on probing (bop), gingival index (gi), and plaque index (pi), were also recorded. enzyme-linked immunosorbent assay (elisa) was used to determine hs-crp levels in biological samples.


Eligibility criteria:
inclusion criteria: * systemically healthy * periodontally clinical healthy * at least 20 permanent teeth in the mouth * no medication for continuous use * those who have not used antibiotics, anti-inflammatory and systemic corticosteroid drugs in the last 6 months. * not in pregnancy or lactation period. * not received periodontal treatment in the last 6 months * for the non-smoker group; person who does not smoke tobacco * for the light-smoker group; person who smokes less than 10 cigarettes a day * for heavy-smoker group; person who smokes more than 10 cigarettes a day exclusion criteria: * any oral or systemic disease * regularly using a systemic medication * during pregnancy or lactation * received periodontal treatment within the last 6 months. * those who received antibiotic, anti-inflammatory or systemic corticosteroid medication in the last 6 months * individual with periodontal disease
effect of cervical occlusion during intrauterine insemination (iui)

Conditions: Infertility

Summary: study hypothesis: there is a difference in pregnancy rates between intrauterine insemination (iui) in cycles performed with cervical occlusion by a balloon catheter designed for sonohysterograms as compared to those performed with a standard inseminator. the investigators will compare pregnancy rates in patients undergoing routine iui either with balloon occlusion or with standard insemination. the patients will receive the standard clinical care per the investigators' office guidelines, except they will be randomized to insemination with either of two catheters.

an open speculum will be used and patients will undergo insemination with their partners sperm (same quantity in both arms). if randomized to treatment arm a balloon catheter will be filled with 1cc of air prior to insemination. the speculum will be removed immediately and the catheter will be left in for 15 minutes and then removed. pregnancy outcomes will be recorded in both groups.

Eligibility criteria:
inclusion criteria: * all patients undergoing iui for unexplained infertility in our office: center for reproduction and infertility (providence, ri) exclusion criteria: * "abnormal" semenalysis tmc \< 5 million * blocked fallopian tubes
a study of the use of hepatitis c positive donors for hepatitis c negative lung transplant recipients with post-transplant treatment with mavyret

Conditions: Hepatitis C

Summary: patients who are hepatitis c negative (hcv negative) and are on the waiting list for a lung transplant at nyulh who consent to participate in this study will receive a lung transplant from a deceased donor that is hcv positive. patients will initiate treatment for hcv with the pan-genotypic agent, mavyret, on the day of surgery and will complete the full 8-week treatment course. patients will be monitored post-transplant for the development of viremia, and for the time course of clearance of viremia among those who develop viremia.


Eligibility criteria:
inclusion criteria: recipient criteria: * listed for an isolated lung transplant at nyu langone health * between 18-70 years of age * able to travel to the nyu langone health for routine post-transplant visits and study visits for a minimum of 6 months after transplantation * no active illicit substance abuse * weight at least 40kg * women of childbearing potential must agree to use birth control in accordance with mycophenolate risk evaluation and mitigation strategy (rems) after transplant due to the increased risk of birth defects and/or miscarriage * both men and women must agree to use at least one barrier method after transplant to prevent any secretion exchange * able and willing to provide informed consent donor criteria: * detectable hcv rna by nucleic acid test (nat) or positive anti-hcv antibody * donor lung meets standard nyu langone health clinical criteria for procurement exclusion criteria: recipient criteria: * hiv positive * hcv rna positive or history of previously treated hcv * evidence of active hepatitis b infection or on active antiviral treatment for hbv * pregnant or nursing (lactating) women * use of strong cyp3a inducers * requires multi-organ transplant donor criteria: * confirmed hiv positive * confirmed hbv positive (positive hepatitis b surface antigen, and/or detectable hepatitis b virus dna) * known previously failed treatment for hcv * donor age \>60 years
effectıveness of cognıtıve behavıoral-based psychoeducatıon in college students wıth smartphone addıctıon

Conditions: Addictive Behavior

Summary: this study aims to determine the effectiveness of the group psycho-education program which is prepared as "cognitive behavioural-based", on college students' smartphone dependency levels. the research will be carried out on students studying at a private foundation university in 2019-2020 academic year. in this study, pre-test-final test control group and follow-up measured experimental pattern will be used to determine the effect of psycho-education program on smartphone dependency levels of college students. a personal information form and smartphone dependency scale will be applied to students who agree to participate in the study. by analysing the data results obtained from the data collection tools and passing the determined limit value, 94 people will be randomly selected, including 47 experiments and 47 control groups, from those who scored high on the smartphone dependency scale through the spss program using the power analysis method. students will be informed about cognitive behavioural based psychoeducation and will be asked if they wish to participate in the training. psychoeducation practice 1 day per week, 60-90 min. sessions will take 8 weeks. at the end of the training, the final test will be applied to the experimental and control group. 3rd and 6th month follow-up measurements are planned to be carried out intermittently at the end of the month. in the literature, it is observed that the number of intervention studies is very small, and no clear conclusions have been reached. in addition, the treatment of smartphone addiction in turkey with cognitive-behavioural approach-based group psychoeducation program has not been studied before. in our country, where smartphone addiction is increasing every day, the importance of intervention efforts in this area is clear. it is anticipated that the intervention study on addiction reduction will be supportive for researchers and will be beneficial for people who need support for smartphone addiction. in this respect, it is thought that it will be a guiding work for future clinical and academic studies.


Eligibility criteria:
inclusion criteria: being over 18 years old higher smartphone addiction scale score exclusion criteria: -

Keywords: addiction, smartphone cognitive behavioral therapy psychoeducation
operative versus nonoperative treatment for scapula fractures

Conditions: Scapula Fracture; Clavicle Fracture

Summary: the purpose of this study is to contrast and evaluate the functional outcome of patients with operative vs. nonoperative treatment of scapula fractures. the specific aim of this project is to monitor the return to function of patients in both the operative and nonoperative cohorts. the potential impact is a clearer set of choices in treatment options for this type of injury.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * displacement of glenoid neck and scapula body of greater than 2 cm * angular deformity between the fracture fragments of greater than 45 degrees. * a combination of displacement greater than 1.5 cm and angulation greater than 30 degrees * a glenopolar angle less than 22 degrees * a double lesion of the superior shoulder suspensory complex (sssc) exclusion criteria: * age less than 18 years old * brachial plexus injury * traumatic brain injury or cognitive disability preventing participation in the consent or post injury rehabilitation * spinal cord injuries resulting in paraplegic, quadriplegic disabilities or permanent ipsilateral peripheral nerve damage * ipsilateral upper extremity injury * previous shoulder surgery * insufficient english proficiency to complete the dash questionnaire

Keywords: displaced scapula fracture scapula fracture extraarticular scapula fractures clavicle
observational study of biomarker during liver surgery

Conditions: Liver Cancer; Hepatobiliary Tract Adenomas and Carcinomas

Summary: the investigators would like to study whether sirtuin 1 (sirt1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver diseases.

if asked to participate in this research study, it is because a liver resection/liver transplantation surgery has been scheduled. during the procedure a small section will be collected for additional testing of sirtuin 1. in addition, information concerning the liver disease, laboratory and pathology results after surgery will be collected by the investigators.

Eligibility criteria:
inclusion criteria: * liver resection \> 2 segments, * plate count \> 100 x 109/l, and * prothrombin activity \>60%. exclusion criteria: * liver cirrhosis, * portal hypertension, * steatohepatitis or severe steatosis, * patients receiving additional ablation therapies, * laparoscopic resection, and * simultaneous extrahepatic procedures such as colorectal resection or pancreatoduodenectomy

Keywords: liver ischemia reperfusion
relationship between the nutritional habits and relapsing and disability rates in patient with multiple sclerosis.

Conditions: Nutrition Habits in Multiple Sclerosis

Summary: patient with multiple sclerosis will undergo and completed comprehensive survey measuring body mass index and assessment of obesity ,health related quality of life,disability,relapsing and complete data on their dietary habits.


Eligibility criteria:
inclusion criteria: * 20 to 40 years of age * males or females * all cases of diagnosed multiple sclerosis under treatment or not exclusion criteria: * disable cases * long standing disease more than five years.
investigation of the safety and efficacy of long term administration of eszopiclone in insomnia patients

Conditions: Insomnia

Summary: to investigate the safety and efficacy of administration of eszopiclone for 6 months in insomnia participants.


Eligibility criteria:
inclusion criteria: 1. participants who have completed lun01s and need to continue eszopiclone

Keywords: insomnia
performance of neurally adjusted ventilatory assist (nava) during spontaneous breathing trial

Conditions: Respiratory Failure

Summary: the purpose of this study is to compare a new mode of mechanical ventilation (nava, or neurally adjusted ventilatory assist) with a traditional mode (pressure support ventilation) on its the ability to detect patients ready for extubation (liberation from mechanical ventilation).

patients under mechanical ventilation who are suspected to be recovered and ready to return to spontaneous ventilation often undergo an spontaneous breathing trial (sbt) before extubation and liberation from mechanical ventilation. during the test, which lasts from 30 minutes to 2 hours , the patient receives minimal support from the ventilator, and the icu team observes if the patient develops any signs or symptoms of discomfort or respiratory distress. if the patient tolerates the test, he or she is considered ready for extubation. the neurally adjusted ventilatory assist (nava) is a new mode of ventilation, shown to improve patient-ventilator synchrony. it has not been tested during sbts. our objective is to compare the performance of nava with the commonly used pressure support ventilation, during an sbt. patients considered to be ready for an sbt by the icu team will undergo two sbts in random order: one in pressure support, and the other on nava, with a 1-hour interval between the tests. ventilatory parameters and patient-ventilator interaction variables will be compared among the two tests. this study will help us understand if nava can be used during an sbt, which might be important for patients who are being ventilated with nava before the sbt is suggested, especially those how present a high asynchrony rate when ventilated with pressure support mode.

Eligibility criteria:
inclusion criteria: * mechanical ventilation for more than 48 hours * considered ready for an spontaneous breathing trial by the icu team * informed consent for participation on the study signed by a family member exclusion criteria: * age \< 18yrs * pregnancy * facial trauma or burns that might interfere with the esophageal catheter placement * nasal pathologies that prevent adequate placement of the catheter * esophageal varices or gastroesophageal bleeding in the past 30 days

Keywords: artificial, ventilation mechanical ventilation weaning
the neoclose abdominal closure vs carter-thomason trial

Conditions: Surgical Port Site Hernia

Summary: the purpose of this study is to compare the neoclose abdominal closure to the standard carter-thomason closure in a bariatric surgery gastric bypass population.

both the neoclose abdominal closure to the standard carter-thomason closure will be used to close 12 mm camera port sites and 12 mm stapler port sites upon completion of a robotic assisted laparoscopic gastric bypass. the procedure requires a 12 mm port site be placed in the midline approximately 3 cm cephalad to the umbilicus and a second 12mm port site in the right mid abdomen. port sites will be closed as defined as the inability to palpate a fascial defect and the incision being air tight upon carbon dioxide insufflation.

Eligibility criteria:
inclusion criteria: * morbid obesity (bmi \> 35). * completed multimodality pre operative evaluation (psychology, nutrition, support groups). * approved for robotic assisted laparoscopic gastric bypass. exclusion criteria: * previous midline laparotomy or weight loss procedure.
intraabdominal pressure in critically ill patients

Conditions: Critical Illness; Intra-Abdominal Hypertension

Summary: this study is conducted to evaluate the incidence and prognostic significance of iah in medical icu patients.

increased intra-abdominal pressure (iap) is an important cause of morbidity and mortality in icu patients with consequent pulmonary, hepatic, central nervous and renal system impairments. the increase in iap is rarely diagnosed in icu and the lack of diagnosis of this condition may lead to the worsening of patient prognoses because of retardation of appropriate interventions . the current literatures show conflicting cutoff values of iap that predict aki, possibly due to the fact that many studies were conducted before publishing of the first consensus of iah/acs, which standardized the measurement method of iap. intra-abdominal hypertension is defined as a sustained or repeated pathologic elevation of intra-abdominal pressure greater than 12 mmhg \[malbrain et al 2004, cheathamml et al 2007\]. intra-abdominal hypertension is graded as follows: * grade i intra-abdominal pressure 12-15 mmhg. * grade ii intra-abdominal pressure 16-20 mmhg. * grade iii intra-abdominal pressure 21-25 mmhg. * grade iv intra-abdominal pressure greater than 25 mmhg various risk factors contribute to the development of iah in medical icu including; massive fluid resuscitation (\> 3500 ml/24 h), ileus, respiratory, renal, or liver dysfunction, hypothermia, acidosis, anemia, oliguria, and hyperlactatemia .

Eligibility criteria:
inclusion criteria: • all patients admitted to the critical care unit of internal medicine department not listed in the exclusion criteria. exclusion criteria: * patients diagnosed with esrd on dialysis. * patients with contraindications for internal urethral catheterization as urethral injury. * patients who had an obvious increase in iap as; pregnant women and obese with body mass index (bmi) \> 32 kg/m2.