Kornimate/medical-research-clean huggingface dataset:
inter-device reliability of the npi-300 pupillometer

Conditions: Critical Illness; Neuropathy

Summary: the purpose of this study is to explore the inter-device reliability between the npi-200 and npi-300.

paired assessments will be made on patients who are consented; and on healthy controls who have verbally assented to participate. we plan to enroll 20 patients and 50 healthy controls. assessments will be made at the convenience of the patient and healthy controls. each assessment will include bilateral plr reading within a 5 minute interval. the first assessment will be completed with the npi-200 and the second assessment will use the npi-300. the data will be entered into a crf. if there is a significant difference between readings from the npi-200 and the npi-300, we will repeat the bilateral assessment in the following hour and the regularly scheduled time.

Eligibility criteria:
inclusion criteria (patient cohort): * subjects will be included if they are adults (\>18 years of age) and have a neurological or neurosurgical diagnosis that place them at risk for cerebral edema. subjects also have to be admitted to the enrolling site. persons consenting for the study (whether patient or lar) will need to be able to consent for the study in english. exclusion criteria (patient cohort): * patients that will be excluded from the study are those that are prisoners, under 18 years of age, or pregnant women. inclusion criteria (healthy control cohort): * staff in the enrolling site exclusion criteria (healthy control cohort): * none
a clinical study of the go-lif® approach for lumbar spinal fixation

Conditions: Lower Back Pain

Summary: the purpose of this study is to collect data regarding the safety and feasibility of the go-lif procedure for spinal fixation and stabilization, in conjunction with conventional approaches for interbody lumbar fusion. this is in order to allow for evidence-based comparison to pedicle-screw-based techniques as described in the literature.


Eligibility criteria:
inclusion criteria 1. men and women, 18-80 years of age. 2. the capability to comprehend the nature and rationale of the study and to consent to participating in the study. 3. unequivocal medical indication for the fixation surgery of a single motion segment of the lumbar spine. 4. correct coronal profile of the lumbar spine. an asymmetric collapse of the disk space in the coronal plane between the vertebral bodies envisioned for instrumentation is by itself not an exclusion criterion. or any of criteria below: 1. patients with grade ii or grade iii spondylolisthesis in the sagittal plane with preserved or normal sagittal alignment requiring single-level instrumented interbody fusion from l1 to s1. (not excluding patient with a need to decompression) 2. patients must have normal alignment of the spine in the coronal view. 2. the interbody fusion approach may be tlif or plif or alif or other, as clinically indicated. 3. the procedure may be combined with a micro-decompression and/or micro-discectomy and/or direct or indirect decompression and/or laminectomy or laminotomy and/or other procedures, as clinically indicated - as long as such procedures do not compromise the structural integrity of the pedicles of the inferior vertebra or the vertebral body of either vertebra of the levels involved.. 4. patient is 18 years or more 5. patient is willing and able to comply with study requirements exclusion criteria: 1. lumbar hyperlordosis \> 70° between the end plate of the lumbar vertebral body 1 and the end plate of the sacral vertebral body 1. 2. deformities of the vertebral bodies envisioned for instrumentation or the sacrum. 3. spondylolisthesis \> grade 2 acc. to meyerding. 4. scoliosis and other deformities in the coronal plane. 5. fractures of the vertebrae envisioned for instrumentation. 6. osteoporosis or osteopenia (see below for examination criteria). 7. therapy with systemic corticosteroids or immunosuppressants. 8. bone metabolism diseases, such as osteomalacia or paget's disease. 9. post inflammatory instability of the vertebral spine. 10. state after radiation therapy of the relevant vertebral spine region. 11. current marcoumar or heparin therapy for more than 6 months at the time of operation. 12. malignant diseases with or without bone metastases. 13. immunologic-inflammatory diseases (e.g., rheumatoid arthritis). 14. diabetes mellitus. 15. infectious diseases. 16. bmi \> 30.
trial using motivational interviewing positive affect and self-affirmation in hypertension (triumph)

Conditions: Hypertension

Summary: the primary aim of this study is to evaluate whether an intervention that combines positive affect and self-affirmation with motivational interviewing (triumph) improves blood pressure control compared to an educational/behavioral contract intervention at 12 months. we hypothesize that a greater proportion of participants in the experimental arm of triumph will have adequate blood pressure control as defined by seventh joint national committee on detection, evaluation and treatment of hypertension (jnc-7.)

triumph is designed to build on the findings of our previous studies by combining positive affect and self affirmation with motivational interviewing in order to increase blood pressure control in community based practices that care for large numbers of hypertensive black patients. patients in both the educational and behavioral contract control group and would receive a workbook, would make a behavioral contract, and a home blood pressure monitor. the positive affect/self-affirmation group would receive the same components as the control group. in addition the experimental group would receive a positive affect/self-affirmation induction and motivational interviewing. both the control group and the experimental group would be followed at 2 month intervals. the outcome blood pressure control in this group will be contrasted to the knowledge/behavioral contract group. we hypothesize that we can increase the percent of patients who have blood pressure control to 75%.

Eligibility criteria:
inclusion criteria: * 18 years or older. * must be receiving care within the renaissance health network for at least one year. * must have uncontrolled htn defined as an average sbp\>140 mmhg or dbp\>90 mmhg on at least two previous visits in the past year and be taking at least one antihypertensive medication. * must self-identify as black, or african american. * must have patient's physician to participate in the study. exclusion criteria: * being deemed unable to comply with the study protocol (either self-selected or by indicating during screening that he/she could not complete all requested tasks). * participation in other clinical trials. * diagnosis of cognitive dysfunction or significant psychiatric comorbidity.

Keywords: hypertension high blood pressure
early airway response to allergen in asthmatics (mk-0000-176)

Conditions: Asthma

Summary: this study will assess the early airway response (ear) associated change in forced expiratory volume in one second (fev1) and plasma 9α-11ß-pgf2 ('9p') after single dose pretreatment of nedocromil, montelukast, and mometasone.


Eligibility criteria:
inclusion criteria: * history of mild to moderate asthma * in good general health (except for asthma) * stable and free of respiratory infection * nonsmoker * females highly unlikely to conceive (surgically sterilized, postmenopausal, or agrees to use 2 acceptable methods of birth control) exclusion criteria: * nursing mother * recent or ongoing upper or lower respiratory tract infection * unable to refrain from or anticipates the use of any prescription and non-prescription drugs * consumes excessive amounts of alcohol or caffeine * history of stroke, chronic seizures, or major neurological disorder * history of cancer * received a vaccination within the past 3 weeks
higher irradiance in keratoconus ectasia

Conditions: Keratoconus; Ectasia

Summary: the purpose of the study is to see if brighter lights will allow for shortening of the treatment time required to stabilize the eyes of patients with keratoconus or a bulging cornea. the investigators will be comparing the therapeutic effects of two different higher brightnesses of ultra violet light on a riboflavin treated eye. one light will be twice as bright as the other and the exposure time of these brighter lights to deliver equivalent energy to the cornea will be reduced from the standard 30 minutes to 10 and 5 minutes. riboflavin is vitamin b2 and the investigators are trying to determine if an identical clinical effect can be achieved the brighter treatment lights are used for shorter times. the investigators will also monitor the clinical effect and the status of the cornea to see if additional risks are associated with the brighter light.


Eligibility criteria:
inclusion criteria: subjects who have one or both eyes that meet two of the following criteria will be considered candidates for this study: 1. 16 years of age or older 2. having a diagnosis of progressive keratoconus or pellucid marginal degeneration. 1. characteristic pattern of deformity as analyzed by the pentacam map. 2. minimal thickness of 350 microns 3. the ability to sign a written informed consent 4. states a willingness and ability to comply with schedule for follow-up visits 5. subject willing to remove contact lenses prior to evaluation and treatment inclusion criteria for ectasia 1. history of having undergone a keratorefractive procedure and show: 1. steepening by pentacam study 2. thinning of cornea 3. shift in the position of thinnest portion of cornea 4. unstable refraction with increasing myopia and astigmatism 5. development of irregular astigmatism 2. at least two of the above criteria must be present. exclusion criteria: subjects meeting any of the following criteria will be excluded from this study: subjects meeting any of the following criteria will be excluded from this protocol: 1. eyes classified as either normal or atypical normal, 2. corneal pachymetry ≤ 350 microns at the thinnest point in treatment zone measured by pentacam. 3. a history of delayed epithelial healing. 4. pregnancy (including plan to become pregnant) or lactation during the course of the study 5. a known sensitivity to study medications 6. patients with nystagmus or any other condition that is severe enough to prevent steady gaze during the treatment 7. inability to cooperate with diagnostic tests. 8. patients with a current condition that, in the investigator's opinion, would interfere with or prolong epithelial healing. 9. patients who are unable to remain supine and tolerate a lid speculum.

Keywords: keratoconus ectasia uva light riboflavin post-lasik irregular astigmatism
association between types of pain and motor activities physical activity

Conditions: Spinal Cord Injury; Chronic Pain

Summary: this study will investigate the relationships between: (1) physical activity (pa) and types of chronic pain (nociceptive and neuropathic), and (2) virtual reality (vr) and types of chronic pain (nociceptive and neuropathic).

chronic pain can be differentiated by its underlying mechanisms. however, this important distinction is not applied to most non-pharmacological treatment approaches. studies that have shown modulation of chronic pain with physical activity (pa) or virtual reality (vr) have not evaluated differential effects on nociceptive and neuropathic pain. therefore, it is unknown if neuropathic pain and nociceptive pain respond differently to pa and vr, and if treatment could be optimized through targeted interventions or a combination of interventions. understanding the relationships between different types of pain and motor activity will provide new insight to inform future recommendations to alter pa levels for pain modulation. a prospective, cohort design will be employed for this study of individuals with sci for a duration of one week in the community. this study will identify trends that are different between the responses of different types of pain and motor activities (i.e., pa and vr). the data obtained will also capture fluctuations in pa levels across participants and corresponding pain levels because pa levels will be collected through real-world data in the community.

Eligibility criteria:
inclusion criteria: * diagnosis of spinal cord injury (sci) (at least six months post-sci) * experienced chronic pain for a duration of at least 6 months * functionally able to self-propel a manual wheelchair * medically stable exclusion criteria: * history of motion sickness or epilepsy * condition in which pa is medically contraindicated

Keywords: physical activity virtual reality nociceptive pain neuropathic pain
aerobic exercise training in pulmonary arterial hypertension

Conditions: Pulmonary Arterial Hypertension

Summary: decreased exercise capacity, peripheral muscle strength and quality of life and increased dyspnea and fatigue perception is prevalent in patients with pulmonary arterial hypertension. it was demonstrated exercise training has beneficial effects in patients with pulmonary arterial hypertension. however, no study investigated the effects of upper extremity aerobic exercise training, therefore effects of upper extremity aerobic exercise training on outcomes in patients with pulmonary arterial hypertension.

patients were diagnosed with pulmonary arterial hypertension according to the task force for the diagnosis and treatment of pulmonary hypertension of f the european society of cardiology (esc) and european respiratory society (ers). primary outcome measurement was exercise capacity, secondary outcomes were respiratory and peripheral muscle strength, physical activity, quality of life, fatigue, dyspnea and depression.

Eligibility criteria:
inclusion criteria: * clinically stable * under standard medication * group 1 pulmonary arterial hypertension patients * having no exacerbation or infection exclusion criteria: * cognitive disorders * orthopedic and neurological problems * pneumonia or acute infection * stage 4 heart failure * having no comorbidity to avoid performing evaluation and training

Keywords: pulmonary arterial hypertension aerobic exercise training upper extremity exercise capacity
exploration the mechanism of ba-duan-jin therapy in the management of fibromyalgia

Conditions: Fibromyalgia

Summary: fibromyalgia (fm) is a chronic debilitating musculoskeletal pain syndrome. "central sensitization" is an important mechanism of the disease. recent studies have shown that "microbiome-gut-brain axis" imbalance may be one of the important mechanisms of "central sensitization". the purpose of this study was to investigate the therapeutic mechanism of ba-duan-jin therapy in the treatment of fibromyalgia by improving intestinal microecology. the mechanism was evaluated by comparing the results of brain functional mri (fmri) and microbacterial analysis of the patients' stool pre and post treatment .


Eligibility criteria:
inclusion criteria: * meet the 1990 american college of rheumatology (acr) research classification criteria for fibromyalgia and 2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria; * be between the ages of 18 to 70 years; * not taking medication for fm for at least 4 weeks; * no special eating habits. exclusion criteria: * had practiced ba-duan-jin, tai chi, yoga or other forms of qigong exercise within 12 months of their recruitment to the study; * be less than 40mm of pain vas score; * had renal failure, severe depression or anxiety; * had any poorly-controlled comorbid medical conditions, such as dementia, cancer, thyroid disease, inflammatory arthritis; * pregnancy or planned pregnancy within the study period; * patients residing more than 70 miles from the research site; * patients with a history of head trauma; * a smoker or drinker; * contraindications for mri,including metal implants, cardiac pacemaker,false tooth, surgical artery clips, metal tattoos or claustrophobia; * patients with cerebral infarction or cerebral hemorrhage.

Keywords: fibromyalgia ba-duan-jin gut microbiota mechanism
recurrent abdominal pain in childhood -characteristics and course

Conditions: Abdominal Pain

Summary: recurrent abdominal pain (rap) is a common complaint in childhood. identification of the processes that maintain illness is important. the purpose of this study is to get more knowledge about characteristics of children with recurrent abdominal pain and their parents, and about the course of their pain. these results may be important to identify children who need treatment.

background: recurrent abdominal pain (rap), mainly constituted by functional gastrointestinal disorders (fgid), affects a significant number of children, and is a result of a complex interaction between biopsychosocial factors. despite the seemingly benign nature of rap, in some children rap is associated with school absenteeism, functional impairment and frequent doctor visits. identification of the processes that maintain illness is important. these results may be important to identify children who need treatment. aims: the aims of this study are to characterize children with rap (in four out-patient clinics) and their parents, describe outcome and determine predictors of persistent rap in children. sample: 150 pediatric patients (4-15 years), their parents and teachers. consecutive new patients referred to four pediatric out-patients clinics for evaluation of abdominal pain (primary complaint). patients with rap (abdominal pain at least once a month, in three consecutive months during the last year, and whose pains are severe enough to affect daily activity) are eligible. design: a prospective cohort study. measurement: all pediatric patients will undergo a complete physical examination emphasizing diagnosing organic illness and fgid according to the international rome classification. routine laboratory will be done. a protocol to identify somatic causes is part of the study. in addition, parents will complete validated questionnaires regarding their child's physical/psychological health, temperamental characteristics and social skills and also psychosocial conditions concerning them selves. self-report regarding the same aspects will be obtained from children above 8-9 years.

Eligibility criteria:
inclusion criteria: * consecutive new pediatric patients (4-15 years) referred by their general practitioners to four pediatric out-patient clinics in innlandet hospital health authorities for evaluation of recurrent abdominal pain. exclusion criteria: * known organic diagnosis for abdominal pain * language problems (which will interfere completing questionnaires)

Keywords: child psychosocial predictors cohort recurrent
implementing digital health in a learning health system

Conditions: Cardiovascular Diseases; Hypertension; Heart Failure; Atrial Fibrillation; Metabolic Syndrome; Genetic Disease

Summary: the need for new models of integrated care that can improve the efficiency of healthcare and reduce the costs are key priorities for health systems across the united states. treatment costs for patients with at least one chronic medical or cardiovascular condition make up over 4-trillion dollars in spending on healthcare, with estimations of a population prevalence of 100-million affected individuals within the next decade. therefore, the management of chronic conditions requires innovative and new implementation methods that improve outcomes, reduce costs, and increase healthcare efficiencies. digital health, the use of mobile computing and communication technologies as an integral new models of care is seen as one potential solution. despite the potential applications, there is limited data to support that new technologies improve healthcare outcomes. to do so requires; 1) robust methods to determine the impact of new technologies on healthcare outcomes and costs; and 2) evaluative mechanisms for how new devices are integrated into patient care. in this regard, the proposed clinical trial aims to advance the investigator's knowledge and to demonstrate the pragmatic utilization of new technologies within a learning healthcare system providing services to high-risk patient populations.

objective #1: determine the effectiveness of handheld imaging and digital health devices on long term health and patient-reported outcomes through pragmatic and randomized clinical trial designs. objective #2: assess the impact of digital health devices and remote patient monitoring (rpm) on measures of healthcare efficiency. measures of healthcare efficiency directly related to digital health technologies and rpm include: identify which interventions can improve care; define the variations in care and; demonstrate within which patient populations digital health technologies are most effective. objective #3: apply integration methods for handheld imaging and digital health devices used for clinical decisions. achieving integration and interoperability-the ability of different information technology systems and software applications to communicate and exchange data with each other-requires identiﬁcation for precisely how new innovations merge into systems of care and are applied to various practice settings.

Eligibility criteria:
inclusion criteria: * all participants of the ase 2018 outreach event who are at least 18 years old who are referred for a cardiac evaluation exclusion criteria: * those not willing to consent

Keywords: digital health handheld ultrasound smartphone ecg mobile health point of care genomics big data artificial intelligence learning health system
correlation between sfrp1 and colorectal cancer and adenoma

Conditions: Early Diagnosis of Colorectal Cancer and Adenoma

Summary: in summary, our study demonstrated the methylation sites of sfrp1 gene promoter in patients with colorectal cancer and adenoma and found sfrp1_16_17_18 cpg site was good performance as a diagnostic marker of colorectal cancer.


Eligibility criteria:
inclusion criteria: * consecutive adult patients undergoing an outpatient endoscopy and histopathologically diagnosed as colorectal cancer or adenoma. also, healthy individuals were invited to be enrolled. exclusion criteria: * lynch syndrome * familial adenomatous polyposis * mutyh associated polyposis * peutz-jeghers syndrome * juvenile polyposis syndrome * serrated polyposis syndrome
observational study on ckd treatment with a ketosteril supplemented protein-restricted diet (keto-027-cni)

Conditions: Chronic Kidney Disease

Summary: the purpose of this study is to characterise the patient and disease profile under the influence of a protein-restricted diet supplemented with keto acids/amino acids (ka/aa), focusing on the progression of chronic renal insufficiency, calcium and phosphorus metabolism, nutritional status, patient compliance to diet and ketosteril intake as well as the persistent dietary education to ensure compliance in a large group of pre-dialysis patients.


Eligibility criteria:
inclusion criteria: * written informed consent * non-dialyzed patients with ckd * indication for ketosteril according to summary of product characteristics (smpc), including a glomerular filtration rate (gfr) \< 25 ml/min * accepted supplemented protein-restricted diet and newly starting with ketosteril (treatment naïve, i.e., never treated with ketosteril before) * adult patients ≥ 18 years exclusion criteria: * active cancer diseases * pregnancy or breast feeding * hypersensitivity to active substances or to any of the excipients in ketosteril * hypercalcaemia * major disorder of amino acid metabolism, e.g., hereditary diseases * participation in any clinical trial with an investigational drug within 30 days prior to start of study or during the study * illiteracy or incapability to read or write