Kornimate/medical-research-clean huggingface dataset:
simulated screening study for breast imaging

Conditions: Breast Cysts; Breast Tumors

Summary: this is a pilot, simulated breast cancer screening study. the goal of the study is to explore these scanning modalities: 1) combined digital breast tomosynthesis(dbt)/dual-sides 3 dimensional-automated ultrasound(aus) 2. explore the utility of photoacoustic imaging as an adjunct to digital breast tomosynthesis(dbt)/ultrasound(us)alone.

this is a pilot, simulated breast cancer screening study. in a population enriched with mammographic call-backs, we will study whether: 1) combined digital breast tomosynthesis(dbt)/dual-sides 3 dimensional-automated ultrasound(aus)will result in a lower call-back rate than digital breast tomosynthesis(dbt)alone. 2. explore the utility of photoacoustic imaging as an adjunct to digital breast tomosynthesis(dbt)/ultrasound(us)alone. this study will compare two new breast imaging systems to digital mammography and hand-held ultrasound that are commonly used to find and evaluate breast masses. images will be done with digital breast tomosynthesis (dbt) and 3-d automated ultrasound(aus) which will be done in the breast imaging clinic of the main hospital followed by the second light and ultrasound imaging that will be completed in the research lab.

Eligibility criteria:
inclusion criteria: * women with possible masses * all women should have had mammograms at university of michigan health system within 1 year before this research study. exclusion criteria: * women who are physically unable to tolerate the length of the scan. * women who are less than 30 years of age or older than 80 years of age * women who are pregnant or lactating * women whose mass is in an area of the breast which makes it difficult to see in the research scans * womens with a single diagnosis of mammographic calcifications * women who have had a breast cancer with lumpectomy * women who are prisoners * women who are students or staff of investigators * women who cannot give consent * women with mammograms classified as probably benign because of follow-up of a recent benign biopsy. * women with breast pain who have been categorized as birads(breast imaging reporting and data system) category 0(incomplete) on their most recent mammograms. * males, because their breast tissue is not easily imaged and numbers of potential cases are too few.

Keywords: automated ultrasound imaging (aus) digital breast tomosynthesis (dbt) photoacoustic imaging (pat)
glucose control in pre-diabetic renal transplant patients

Conditions: Impaired Glucose Tolerance; Kidney Transplantation

Summary: development of new-onset diabetes after transplantation (nodat) is common and serious complication after kidney transplantation. patients who develop nodat are at increased risk for loss of the transplanted organ and for diseases of the cardiovascular system. it is believed that in many patients the development of overt nodat is preceded by a phase of impaired glucose tolerance that is called pre-diabetes. this study aims at improving glucose metabolism in patients after kidney transplantation who are in a pre-diabetic metabolic state. patients who exhibit impaired glucose tolerance (igt) after kidney transplantation are randomized to either receive vildagliptin (galvus), pioglitazone(actos) or placebo for three months. the investigators hypothesize that treatment with vildagliptin or pioglitazone leads to improved glycemic control compared to placebo.


Eligibility criteria:
inclusion criteria: * time since renal transplantation \> 6 months * stable graft function * routine ogtt has been performed, and pre-diabetes has been diagnosed by pathological ogtt (2h, 75 g glucose, glucose level between 140 and 200 mg/dl) * informed consent of the patient exclusion criteria: * patients with type 1 or type 2 diabetes * patients with nodat (2h glucose level at ogtt \>200 mg/dl) * allergy against vildagliptin or pioglitazone * pregnancy * gfr\<15ml/min/1.73 with need for dialysis * hepatic impairment

Keywords: after
telephone and mail intervention for alcohol use disorders

Conditions: Alcohol Use Disorders

Summary: randomized controlled trial and benefit-cost study of a telephone and mail intervention for non-treatment-seeking primary care patients with alcohol abuse or dependence


Eligibility criteria:
inclusion criteria: * primary care patients with dsm-iv alcohol abuse or dependence exclusion criteria: * pregnancy * suicidality * alcohol treatment in prior 3 months
mental health disparities in spanish speaking latina breast cancer patients

Conditions: Breast Cancer; Depression, Anxiety; Mindfulness; Sleep Disturbance

Summary: the purpose of the study is to:translate a mindfulness program into spanish for latina patients with breast cancer.train a community health worker to facilitate the mindfulness program. determine if this program is culturally acceptable and feasible, and obtain pilot data on the program's effectiveness in reducing anxiety and depression

primary aims of this study are to: 1) translate a behavioral health intervention into spanish, 2) deliver it to a population of spanish speaking latina breast cancer patients, and 3) determine acceptability and feasibility. secondary aims are to gather preliminary data on anxiety, depression and sleep quality pre and post intervention.

Eligibility criteria:
inclusion criteria: * self reported diagnosis of invasive breast cancer who has currently or within last 12 months been in active treatment (surgery, chemotherapy, or radiation) or on endocrine therapy * self-identified anxiety (persistent worry or nervousness), depression (feeling sad, little interest or pleasure in doing things or hopeless), or sleep disturbance. * breast cancer related treatment (surgery, radiation, chemotherapy) or endocrine therapy within the last 12 months * self identifies as spanish speaking * self identifies as latinx / latina / latino * ability to understand and the willingness to sign a written informed consent document. exclusion criteria: * non-spanish speaking * other diagnosis besides invasive breast cancer (ie ductal carcinoma in situ (dcis), fibroadenoma, abnormal mammogram but not yet with final diagnosis, non-breast cancer patients) * comorbid bipolar affective disorder or psychotic disorder (as self-identified by patient after asking "do you have any other psychiatric conditions") * inability to physically or psychologically attend group sessions, and by discretion of the study coordinator. * patients currently participation in stress reduction or mindfulness groups/interventions will be excluded from participation * cancer "survivors" if not in active or endocrine treatment

Keywords: behavioral intervention spanish speaking latina breast cancer mindfulness
evaluation of the safety and effectiveness of the oculeve intranasal lacrimal neurostimulator in patients with dry eye

Conditions: Dry Eye Syndromes

Summary: the purpose of this study was to evaluate the safety and effectiveness of the intranasal tear neurostimulator applied intranasally compared with the same device applied extranasally (control) in treating the symptoms of dry eye exacerbated by the controlled adverse environment (cae) model.


Eligibility criteria:
inclusion criteria: * bilateral dry eyes * capable of providing written informed consent exclusion criteria: * chronic or recurring epistaxis (nosebleeds) * uncontrolled systemic disease * blood coagulation disorder * females who are pregnant, nursing or planning a pregnancy

Keywords: dry eye syndrome keratoconjunctivitis ophthalmic eye disease corneal disease keratitis
the impact of placental factors on fetal intrauterine growth and in intrauterine programming of the metabolic syndrome

Conditions: Normal Pregnancies

Summary: genetic and environmental factors are believed to play a major role in intrauterine growth and intrauterine programming. we intend to study genetic factors such as telomere homeostasis, senescence, genomic instability and the presence of genomic copy number variations in placental tissue from pregnancies complicated with intrauterine growth restriction(iugr), gestational and pre gestational diabetes, placentas from ivf pregnancies and from normal pregnancies. we also intend to assess these factors in cord blood and maternal blood.

based on the previous data from our group as well as other laboratories, we postulate that there is a correlation between impaired telomere homeostasis, senescence genomic instability and intra-uterine programming in placentas and in fetuses exposed to suboptimal intrauterine conditions such as hypoxia or hyperglycemia. improved understanding of the mechanisms that produce the genomic changes in iugr placentas and their influence on later risks of developing the metabolic syndrome should provide basis for future research that might lead into improved outcome of iugr fetuses.

Eligibility criteria:
inclusion criteria: * a diagnosis of intrauterine growth restriction * a diagnosis of gestational diabetes * a diagnosis of pre gestational diabetes * ivf pregnancy exclusion criteria: * chorioamnionitis * meconium stained amniotic fluid * a request of the patient for cord blood retrieval for preservation
auricular acupuncture as part of a multimodal regimen after distal radius open reduction and internal fixation

Conditions: Radius Fracture Distal; Pain, Postoperative

Summary: this randomized controlled trial will test the hypothesis that patients receiving an intraoperative auricular acupuncture protocol will require less postoperative opioid analgesic use compared to those who do not receive acupuncture in the setting of a multimodal analgesic protocol for patients receiving surgery to repair distal radius fractures at a level 1 trauma center under brachial plexus anesthesia with sedation.


Eligibility criteria:
inclusion criteria: * patient ages 18-64 * american society of anesthesiologists physical status 1, 2, or 3 * patients scheduled to undergo distal radius orif under brachial plexus nerve block exclusion criteria: * renal dysfunction (serum cr \> 1.2) - excluded due to potential for altered metabolism of anesthetic and perioperative medications * allergy to any of the standard anesthetic agents * patient inability to properly communicate with investigators * patient or surgeon refusal
to investigate the incidence of obstructive sleep apnoea in patient undergoing open heart surgery

Conditions: Obstructive Sleep Apnoea

Summary: this is a study to investigate the incidence of obstructive sleep apnoea in patient undergoing open heart surgery . this will include enrolment of 400 patient undergoing open heart surgery .


Eligibility criteria:
inclusion criteria: * adults male and female , aged 45 years old and above * undergoing open heart surgery that requires hospital stays of more than 5 days exclusion criteria: * previous diagnosis and treatment of osa or any sleep related breathing disorder. * unwilling or physically unavailable for polysomnography before surgery. * patient undergoing maze procedure . * patient with severe copd
safety and efficacy study for various skin conditions

Conditions: Dyschromia; Photodamaged Skin

Summary: characterizing safety and efficacy of halo laser treatment for various skin conditions.

the purpose of this study is to demonstrate safety and efficacy of halo treatment as measured by changes in skin tone, texture and pigment.

Eligibility criteria:
inclusion criteria: * fitzpatrick skin types i to iv * desires improvement of significant skin conditions on the face and/or neck * willingness to participate in the study by signing an informed consent form * will have limited sun exposure for at least two weeks prior to study screening and during the study, including the follow-up period * able to adhere to the treatment and follow-up schedule and post-treatment care instructions * post-menopausal or surgically sterilized female subjects. exclusion criteria: * history of halo or resurfacing procedures in the treatment area within past six months * has tanned within the past thirty days or unable or unlikely to refrain from tanning, including the use of tanning booths, tanning spray, or cream * has tattoos, dysplastic nevi in the treatment area * pregnant and/or lactating * is planning to get pregnant within the study period * has a known history of photosensitivity * has used medication with photosensitizing properties within the past six months, e.g. isotretinoin * history or evidence of chronic or recurring skin disease or disorder (e.g. psoriasis, --netherton syndrome, etc.) affecting the treatment area * has open lacerations, abrasions, active cold sores, or herpes sores * has hormonal disorders * history of keloid or hypertrophic scar formation or poor wound healing * history of immunosuppression or immune deficiency disorder (including hiv infection or aids) or use of immunosuppressive medications * history of bleeding disorder or taking anticoagulation medications * history of skin cancer or any other cancer in the treatment area * has significant concurrent illnesses, such as diabetes, lupus, epilepsy, or cardiac disorders, which might be aggravated as a result of treatment * has participated in any clinical trial involving an investigational drug or cosmetic product or procedure within the past thirty days * the investigator feels that for any reason the subject is not eligible to participate in the study
concentrations of formoterol in blood and urine

Conditions: Asthma

Summary: the purpose of the study is to assess the blood and urine concentrations of inhaled formoterol.

the purpose of the study is to assess the serum and urine concentrations after inhalation of 18 microgram formoterol as one dose. furthermore to investigate the serum and urine concentrations of inhaled formoterol and evaluate the difference between three groups: healthy men, male asthmatic subjects and male elite athletes with asthma.

Eligibility criteria:
inclusion criteria: * physician-diagnosed asthma with positive reversibility or challenge test. * informed consent. * age between 18-45 years. * sex: male. * asthma classified as mild to moderate according to gina guidelines. * used beta-2-agonist in minimum 12 months. exclusion criteria: * smokers or ex-smokers with a smoking history of 10 pack years or more. * respiratory tract infections within the last 2 weeks prior to study day. * subjects with other chronic diseases than asthma and allergy. * allergy towards the study medicine. * use of beta-2-agonist 10 days prior to study day.

Keywords: asthma doping formoterol urinary concentrations beta-agonists
a retrospective analysis to evaluate long term outcomes of scc patients previously treated with alpha dart

Conditions: Squamous Cell Carcinoma; DaRT Treated Patients

Summary: evaluation of long-term efficacy outcomes of patients previously treated with the alpha dart seeds for management of their malignancy following initial response.

medical records of patients that previously underwent the alpha dart treatment will be reviewed by an authorized staff member. evaluation of long-term outcomes of patients previously treated with the alpha dart seeds for management of their malignancy following initial response. these outcomes include: * safety - assessment of late onset of alpha dart related ae in patients treated with the alpha dart seeds * efficacy - * assessment of local recurrence rates in patients who achieved initial complete response (cr) following the alpha dart treatment * assessment of duration of response in patients who achieved initial cr following the alpha dart treatment * assessment of survival status in patients treated with the alpha dart seeds

Eligibility criteria:
inclusion criteria: * patients previously treated with the alpha dart seeds for management of either skin or oral cavity scc * available information in medical charts and records (electronic or paper) exclusion criteria: none.

Keywords: squamous cell carcinoma alpha radiation
working memory training in copd patients: the cogtrain-trial

Conditions: COPD; Cognitive Impairment

Summary: general cognitive impairment is highly prevalent in chronic obstructive pulmonary disease (copd) patients. domain-specific cognitive impairments include deficits in domains such as cognitive flexibility, verbal memory, working memory, planning, and psychomotor speed; which in general are associated with poor health behaviours, such as infrequent exercising and poor diet. additional cognitive training may reverse these effects. recent evidence suggests that working memory training is linked to self-control and, indirectly, to improved lifestyle behaviour including increased physical activity. the investigators hypothesise that enhancing cognitive performance through administering specific working memory training not only improves cognitive function but that it facilitates better adherence to a more active lifestyle and a healthier diet in copd patients.


Eligibility criteria:
inclusion criteria: * primary diagnosis of copd based on the global initiative for chronic obstructive lung disease (gold) guidelines * patients also need to provide written informed consent * be motivated as evaluated by the self-determination questionnaire exclusion criteria: * disease and or disability limiting the ability to undergo a neuropsychological testing battery and/or to follow a working memory training (e.g., blindness) * neurological disorders (e.g., alzheimer's disease or cerebrovascular disease) * insufficient mastery of the dutch language * individuals who during the study period are or will be participating in a pr programme

Keywords: health behavior executive function working-memory training feasibility impulsivity
xen45 in the treatment of chinese patients with primary open-angle glaucoma

Conditions: Glaucoma; Glaucoma, Open-Angle; Surgery

Summary: glaucoma is the second most common blindness disease in the world, second only to cataracts. the current treatment of glaucoma is mainly to reduce intraocular pressure.at present, two commonly used surgical methods are trabeculectomy and implantation of drainage valve. these methods are superior to drug treatment in reducing intraocular pressure, but the effect duration of these two methods is not long, and there may be serious complications and failure. compared with traditional glaucoma surgery, migs may have better safety.the xen45 gel implant is a collagen tube with a length of 6 mm and a diameter of 45 µm, which creates a new channel for drainage of aqueous humor by connecting the anterior chamber and the subconjunctival space. the implant is composed of porcine gelatin cross-linked with glutaraldehyde, and has good biocompatibility and tolerance. therefore, after the advent of xen45 products, more and more studies have shown that this treatment has excellent safety and effectiveness in reducing intraocular pressure in patients with open-angle glaucoma. considering that the xen45 gel stent has been in the market for a relatively short time, we conducted this prospective study to investigate the effect of xen45 surgery in the treatment of primary open-angle glaucoma, in order to support ophthalmologists in formulating the best surgical plan for patients. the promotion of this surgical method.

observation index： the visual acuity, intraocular pressure, slit lamp, ophthalmoscope, traditional vision, ubm and anti-glaucoma drugs before surgery and 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with poag; 2. the visual acuity of the affected eye is greater than that of manual operation; 3. between 18 and 90 years old; 4. no surgery or laser treatment within 90 days; 5. patients with other types of glaucoma whose intraocular pressure has not been controlled by traditional surgery or medication; 6. the target quadrant has healthy conjunctiva and free movement without scars. exclusion criteria: 1. angle-closure glaucoma; 2. active uveitis; 3. any corneal disease; 4. patients with eye infections two weeks before the operation; 5. during pregnancy or lactation; 6. active neovascular glaucoma; 7. known or suspected allergy or sensitivity to pig products or glutaraldehyde.
a study to evaluate the efficacy and safety of ono-4538 in combination with ipilimumab and chemotherapy in chemotherapy-naïve participants with her2-negative unresectable advanced or recurrent gastric cancer (including esophagogastric junction cancer)

Conditions: Gastric Cancer

Summary: this study is to compare and evaluate the efficacy and safety of ono-4538 in combination with ipilimumab and chemotherapy versus chemotherapy in chemotherapy-naïve participants with her2-negative unresectable advanced or recurrent gastric cancer (including esophagogastric junction cancer).


Eligibility criteria:
inclusion criteria: 1. participants with unresectable advanced or recurrent gastric cancer (including esophagogastric junction cancer) that has been histologically confirmed to be predominant adenocarcinoma 2. eastern cooperative oncology group (ecog) performance status (ps) score 0 or 1 3. participants who have a life expectancy of at least 3 months exclusion criteria: 1. participants with a history or complications of multiple cancers 2. participants with a complication or history of severe hypersensitivity to any other antibody products 3. participants with concurrent autoimmune disease or a history of chronic or recurrent autoimmune disease.
nirs to evaluate haemodynamic reserve in paediatric moyamoya

Conditions: Moyamoya

Summary: near infrared spectroscpy is a validated method of evaluating cerebral blood flow. the aim in this pilot study to explore its use in children with moyamoya disease.

moyamoya disease is a cerebrovascular condition in which there is chronic brain hypoperfusion. as surgery can possibly augment brain blood flow, a method for evalutaing cerebrovascualr reserve would be helpful in selecting patients for intervention. near infrared spectroscopy (nirs) is a validated non-invasive method of evaluating cerebral blood flow. we aim to investigate the feasibility and tolerability of using nirs haemodynamic reserve in children with moyamoya and controls by evaluating cerebral blood flow in the baseline state and after breath-holding. feasibility will be assessed by how many successful studies are carried out. tolerability will be assessed by asking children some simple questions about their experience.

Eligibility criteria:
inclusion criteria: patients with moyamoya and unaffected healthy controls - exclusion criteria: age \<6 -