Kornimate/medical-research-clean huggingface dataset:
safety study of the novel drug dimebon to treat patients with huntington's disease

Conditions: Huntington's Disease

Summary: this study is being conducted to determine the safety and tolerability of dimebon in people with huntington's disease after short-term exposure (one week) and after longer exposure (three months). also, the study will assess whether or not there is an effect of dimebon on the symptoms of huntington's disease, including cognitive (thinking abilities), motor (movement), behavior, and overall functioning.


Eligibility criteria:
inclusion criteria: * clinical features of huntington's disease and a confirmatory family history of hd, or a cag repeat expansion greater than or equal to 36 * stage i,ii,iii hd and a total functional capacity greater than or equal to 5 on the unified huntington's disease rating scale exclusion criteria: * clinical evidence of unstable medical illness

Keywords: huntington's disease dimebon dose-escalation phase 1-2a randomized controlled double-blind unified huntington's disease rating scale
trial of modafinil for methamphetamine dependence

Conditions: Amphetamine Dependence

Summary: the study aims to evaluate the safety and efficacy of modafinil (200 mg/day) over 10 weeks plus a tailored cognitive behavioural therapy program in the treatment of methamphetamine dependence.

modafinil is a novel wake promoting agent approved in australia for the treatment of narcolepsy. preliminary studies have suggested that modafinil may have value in the treatment of psychostimulant dependence through positive effects on mood, sleep patterns, concentration, fatigue and drug craving. it appears to be well tolerated with a low abuse potential. sixty dependent methamphetamine users will be allocated to 2 equal groups. the experimental group will receive modafinil 200 mg/day for 10 weeks and a tailored cognitive behavioural therapy program. the control group will receive placebo under equivalent conditions. primary outcome will be a between group comparison of methamphetamine negative urine samples over the 10 week study period. adverse events, side effects, compliance, retention and self reported health, psychosocial and drug use will also be compared between the study groups.

Eligibility criteria:
inclusion criteria: * diagnostic and statistical manual of mental disorders-fourth edition (dsm-iv) amphetamine dependence diagnosis * amphetamine positive urine sample at intake * regular current amphetamine use (2-3 days per week) * aged 18 years or older exclusion criteria: * pregnant or nursing females * hazardous concurrent uncontrolled physical or mental illness

Keywords: modafinil amphetamine dependence randomised placebo-controlled trial
multiple noninvasive examination modality to evaluate the severity of ocular surface disorders

Conditions: Limbal Stem-cell Deficiency

Summary: here the investigators proposed this study to collect cases of different etiologies of ocular surface diseases. with at least one of these four non-invasive examination modalities, the investigators aim to analyze and compare the detecting results. the investigators especially focus on the possibility of using oct to predict the condition of limbal epithelial stem cells, aiming to use this patient-friendly tool to detect the patient's limbal conditions.

in vivo confocal microscopy, anterior segment optical coherence tomography, keratograph and impression cytology are noninvasive, rapid and easily repeatable technique to investigate ocular surface disorders. in vivo confocal microscopy (ivcm) enables morphological and quantitative analysis of ocular surface microstructure. optical coherence tomography (oct) allows for imaging of the morphology of biological tissue with micrometer scale resolution at imaging depths of 1 to 2mm below the tissue surface. \[1,2\] anterior segment oct (asoct) has been developed to evaluate corneal diseases\[3-8\] in different layers. keratography includes noninvasive meibography and tear interferometry. the former demonstrates the morphology of meibomian glands whereas the later observes quality and quantity of the lipid layer of the tear film. impression cytology shows the morphology of the corneal and conjunctival epithelial cells, their staining behavior, and nuclear/cytoplasmic ratio could be observed in detail. here the investigators proposed this clinical trial to collect cases of different etiologies of ocular surface diseases. with at least one of these four non-invasive examination modalities, the investigators aim to analyze and compare the detecting results. the investigators especially focus on the possibility of using asoct to predict the condition of limbal epithelial stem cells, aiming to use this patient-friendly tool to detect the patient's limbal conditions.

Eligibility criteria:
inclusion criteria: * patient who is able to understand and cooperate with the examination: aged over 5 years. * patient or the legal representative is able to read and sign an informed consent form. * patient with one of the diagnosis listed below: 1. limbal insufficiency 2. phlyctenulosis 3. ocular rosacea 4. ocular graft-versus-host disease (gvhd) 5. dry eye syndrome (both aqueous deficiency or increased evaporative forms of dry eyes) 6. other ocular surface diseases (advancing wave-like epitheliopathy, long term use of anti-glaucoma eye drops) exclusion criteria * patients who decline to receive any of the non-invasive examinations mentions in this clinical trial. * patients younger than 5 years old.
prp effectiveness in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: the aim of our study is to determine the effects of intra-articular platelet rich plasma (prp) prepared with two different techniques on pain intensity, functional status, quality of life, functional balance and femoral cartilage thickness in patients with knee osteoarthritis.

osteoarthritis (oa) is the most common form of chronic joint disease. platelet rich plasma (prp) is an injection therapy used to treat chronic painful musculoskeletal conditions, including knee oa. in this prospective, randomized controlled, single blind, interventional study, a total of 75 patients with stage 2-3 knee osteoarthritis according to the kellgren lawrence classification who meet the eligibility criteria will be enrolled in the study. eligible participants will be randomly assigned to one of the three groups using computer-generated random numbers.the patients to be included in the study will be randomized into three groups and the first group will be given platelet-rich plasma (prp) prepared with t-lab / prp kit, the second group will be given prp prepared with t-lab prp injection syringa, and the third group will be given saline injection. home exercise program for knee osteoarthritis will be given to all three groups and the exercise program will be followed by weekly phone calls. during the follow-up period, patients will be asked to continue their current medical treatments, not to make changes in their activities of daily living. participants are going to evaluate before injection, and at the 1-month follow-up and 6-month follow-up using the visual analog scale (vas) scores for pain during activity, at rest, and at night, with the western ontario and mcmaster universities osteoarthritis index (womac) change in pain, stiffness and physical function score, the change in the timed up and go test (tug) time, change in femoral cartilage thickness measurement by ultrasound and the change in the patient's daily activities with the numerical global patient assessment scale.

Eligibility criteria:
inclusion criteria: * patients with chronic symptomatic knee pain between the ages of 30-75 years * presence of kellgren-lawrence stage 2-3 osteoarthritis on current anterior-posterior knee radiographs * functional ambulation scale stage 4-5 exclusion criteria: * intra-articular knee injection within the last six months * history of severe trauma to the knee within the past six months * concomitant severe meniscus or ligament injury, surgery applied to the knee area * presence of severe effusion, inflammatory joint disease, infection, hematological and oncological disease in the knee. * having a bleeding disorder and / or using warfarin * kellgren-lawrence stage 1 or stage 4 osteoarthritis on current anterior-posterior knee radiographs * presence of cardiac or systemic disease that may affect exercise * the presence of neurological disease and psychiatric disease such as parkinson's disease, stroke history that may affect balance * body mass index ≥35 kg / m²

Keywords: knee osteoarthritis platelet rich plasma
weight loss pilot study in postmenopausal breast cancer survivors

Conditions: Breast Cancer; Obesity; Overweight

Summary: the primary objective of this pilot study is to determine the effect of weight loss on a wide range of biomarkers associated with risk of breast cancer recurrence in overweight and obese breast cancer survivors. we hypothesized that weight loss would result in a statistically significant improvement in biomarkers associated with risk of breast cancer recurrence.

women who are overweight, obese or gain weight after a breast cancer diagnosis are at greater risk for recurrence and death compared with lighter women. there have been a few studies examining the effects of different interventions on weight loss in breast cancer survivors but very few have examined the effect of weight loss interventions on circulating levels of markers associated with cancer risk. the overall objective of this proposal is to determine how weight loss affects circulating levels of biomarkers associated with breast cancer risk and recurrence, and quality of life of overweight and obese breast cancer survivors. the central hypothesis is that weight loss will decrease the levels of markers adversely associated with breast cancer and increase quality of life in these women. to test the central hypothesis the following specific aims will be pursued: * to assess the effects of two different weight loss interventions on biomarkers associated with breast cancer risk and recurrence * to assess the impact of the weight loss interventions on quality of life and sleep * to assess the impact of weight loss on measures of bone health

Eligibility criteria:
inclusion criteria: * postmenopausal (defined as experiencing at least 12 months without a menstrual period) * diagnosed with operable invasive breast cancer and treated with mastectomy or with lumpectomy and radiation * completed all surgery, radiation, and systemic chemotherapy one to 12 months prior to enrollment * bmi ≥ 27 kg/m2 * less than 7 servings of alcohol per week * willing to be randomized into either group * not planning to move away from the area during the period of study * non-smoker exclusion criteria: * serious illness requiring medical treatment * inability to participate in physical activity due to severe disability * history of schizophrenia, psychosis or untreated major depression * unwilling to commute to study site once per week * failure to provide written informed consent
effectiveness of two intracanal irrigation solutions

Conditions: Irreversible Pulpitis

Summary: the aim of the present clinical trial is to investigate and compare the effect of crayotherapy utilizing two intra-canal final irrigating solutions on postoperative pain.

1. st: comparison of pain reduction algorism after cryotherapy using the two tested irrigating materials 2. nd. number and frequency of analgesics taken for pain relief during one week postoperative

Eligibility criteria:
inclusion criteria: * case diagnosed as having symptomatic irreversible pulpitis with symptomatic apical periodontitis * patients requiring emergency rct * pre-operative pain score 7 on numerical rating (nrs) scale * middle aged males (25-50) * medical profile asa1 * willing to sign the consent form * willing to answer our call for one week period exclusion criteria: * females * medical conditions above asa1 * multi-rooted teeth * patients younger or older than (25-50)

Keywords: pulpitis chx saline
subjective pain scoring for subtenonal anesthesia during vitrectomy

Conditions: Epiretinal Membranes; Retinal Detachment; Full Thickness Macular Hole

Summary: subtenonal anesthesia is a well-known technique of local anesthesia for patients undergoing pars plana vitrectomies. it was described to be efficient with respect to anesthesia of the eye and it showed less risks compared to retrobulbar or parabulbar anesthesia. purpose of the study is to assess subjective pain scores of patients, that underwent vitrectomy with subtenonal anesthesia.

subtenonal anesthesia is a well-known technique of local anesthesia for patients undergoing pars plana vitrectomies. it was described to be efficient with respect to anesthesia of the eye and it showed less risks compared to retrobulbar or parabulbar anesthesia. subjective pain scores of patients, that underwent vitrectomy with subtenonal anesthesia, are probably different among patients with excessive indentation of the bulbus for retinal detachment repair, compared to patients undergoing vitrectomy with membrane peeling for epiretinal membranes or full thickness macular holes. purpose of the study is to assess subjective pain scores of patients, that underwent vitrectomy with subtenonal anesthesia.

Eligibility criteria:
inclusion criteria * vitrectomy with subtenonal anesthesia in the time-period from 1.12.2022 to 31.8.2023 * indication for surgery: retinal detachment, epiretinal membrane, or full thickness macular hole * questionnaire for subtenonal anesthesia was already answered by the patients * age 18 and older exclusion criteria any of the following will exclude a subject from the study: * surgery in general anesthesia * questionnaire missing or incomplete

Keywords: subjective pain score vas subtenonal anesthesia
effects of wurn technique on dyspareunia, menstrual cramps & qol in infertile women

Conditions: Infertility, Female

Summary: wurn technique is a pt technique. it is site specific massage therapy in the form of relaxing technique, helps to promote the function of abdominopelvic and reproductive organs.

this study will be randomized controlled trial, will be completed in 10 months duration. non probability conveninence sampling technique will be used with 54 participants after randomization. effect will be obseved in 2 groups.

Eligibility criteria:
inclusion criteria: * women with infertility between age 25 to 45 * women who were unable to conceive for 12months with regular unprotected intercourse * women with infertility indicating sexual pain, irregular periods with menstrual cramps. * women with secondary infertility exclusion criteria: * women with active infections and abnormal ovarian cysts. * any abdominopelvic surgery within last 90days. * any medical history of active abdominopelvic cancer or malignancy.
characterization of the relationship between the human mesolimbic reward system and immune functioning

Conditions: Immune Hepatitis

Summary: the purpose of this study is to characterize the link between neurobehavioral measures of the mesolimbic reward system and immune functioning in healthy individuals, via fmri neurofeedback modulation of mesolimbic reward system, and the consecutive assesment of immune response to hepatitis b vaccination.

for many years, the link between mental processes and physical health has remained obscure. yet, over time, studies have begun to shed light on the intimate relationship between one's physical condition and mental state. one body of research aimed at elucidating the mind-body relationship is the study of the placebo effect. placebo effects result mainly from conscious expectations to become healthy in therapeutic settings, and from unconscious conditioned responses to therapeutical settings that predict beneficial outcomes. both processes are asociated with the neuronal reward system, which mediates reward processing, reward valuation and value based-learning. however, it remains unclear how do these processes mediated by the reward system promote therapeutic effects? a recent study established a causal relationship between mesolimbic activation (vta) and a measurable immunological response in mice. stimulation of the vta increased anti-bacterial immune functioning, an effect that was mediated by sympathetic nervous system, which is regulated by the brain and innervates all immune organs. in light of these findings, the current study aims to assess the relationship between reward-related brain activation and immune functions in humans. fmri neurofeedback, a task that allows individuals to self modulate specified neural patterns in real-time, will be used to induce mesolimbic activation, following which healthy individuals will vaccinate against hepatitis b. immunological effects will be assessed by comparing immunological measures with respect to hepatitis b prior and following mesolimbic activation and hepatitis b vaccination. the long-term goal of this study is to demonstrate a causal link between reward activation and an objective measurable physiological response of great significance, and to develop the means for individuals to exploit such mechanism for boosting immune functioning. i.e. to harness endogenous reward-related brain activation to strengthen the immune system, for clinical pathologies such as autoimmune diseases, maleble pathogens, cancer, etc.

Eligibility criteria:
inclusion criteria: * healthy participants * normal or corrected to normal vision * compatibility with general mri requirements exclusion criteria: * history of neurological or psychiatric diseases that lead to hospitalization * have received hepatitis b vaccination in the last 10 years * memory/cognitive neurological impairments * chronic heart disease, diabities, high blood pressure, or autoimmune disease.

Keywords: mesolimbic reward system fmri neurofeedback
cognitive interventions and nutritional supplementation for patients with long-lasting back pain

Conditions: Chronic Low Back Pain

Summary: cins is a large multicentre study which aims to test out the effect of 4 different interventions, namely a brief cognitive intervention (bi), a more extensive cognitive behavioural intervention (cbt), and 2 different nutritional supplementations (seal oil and soy oil) in a population of chronic low back pain patients sicklisted for 2-10 months.

the treatment principles for low back pain, and also other types of non-specific muscle pain, have changed dramatically over the last 10 to 15 years; from traditional treatment like bed rest and inactivity to more active treatment strategies ("the back pain revolution"; waddell et al 1997). norwegian research has been in the forefront, particularly in demonstrating the clinical and cost effective brief interventions (bi) (indahl et al., 1995, 1998; hagen et al 2000, 2004, brox et al 2003, storheim et al 2003). however, about 30% of the patients do not recover or return to normal social and working life. the aim of this study is therefore to see if a longer cognitive behavioural intervention (cbt) has an additional benefit to bi, and to compare this with a potentially beneficial dietary supplement.

Eligibility criteria:
inclusion criteria: * patients sicklisted 2-10 months for low back pain * the following diagnosis are included: l02, l03, l84 and l86 exclusion criteria: * being off the sick list * pregnancy * osteoporosis * cancer * l diagnoses suggesting recent low back pain trauma * specific spinal or other injuries which may account for the current back pain * serious psychiatric pathology

Keywords: chronic low back pain brief cognitive intervention cognitive behavior therapy seal oil
the effects of social role participation on life quality

Conditions: Social Interaction

Summary: the study was carried out among 100 ra patients (age from 20 to 70 years) by fulfilling the american college of rheumatology 1987 revised criteria admitted to our outpatient clinic. ra patients were compared with 95 healthy volunteer control group. participants were asked to complete interview based questionnaires regarding pain, life quality, and social role participation to obtain additional information during the interview to participate in the study in 20 min.

the study was carried out among 100 ra patients (age from 20 to 70 years) by fulfilling the american college of rheumatology 1987 revised criteria admitted to our outpatient clinic. ra patients were compared with 95 healthy volunteer control group. healthy volunteers were recruited from the partners next to the patients who came to our outpatient clinic for examination. the same physician carried out the physical examinations on all participations and conducted a interview, acquiring information on age, gender, body mass index (bmi), marriage status, living alone, working, and education. participants were asked to complete interview based questionnaires regarding pain, life quality, and social role participation to obtain additional information during the interview to participate in the study in 20 min. examinations took place at the our outpatient clinic. this study did not include all participants who had accompanying of other rheumatic diseases, musculoskeletal diseases, the presence of another chronic disease, cancer.

Eligibility criteria:
inclusion criteria:the study was carried out among ra patients (age from 20 to 70 years) by fulfilling the american college of rheumatology 1987 revised criteria admitted to our outpatient clinic - exclusion criteria:this study did not include all participants who had accompanying of other rheumatic diseases, musculoskeletal diseases, the presence of another chronic disease, cancer. -
a study of the efficacy of atorvastatin for lowering cholesterol in high-risk patients with high cholesterol

Conditions: Dyslipidemias

Summary: the purpose of the study is to evaluate the effectiveness of atorvastatin in lowering cholesterol and getting these high risk patients to their goals of ldl \<115 mg/dl across starting doses of 10 mg, 20 mg, or 40 mg with one step titration.


Eligibility criteria:
inclusion criteria: * dyslipidemia * at a high risk for coronary heart disease exclusion criteria: * use of higher than usual maintenance doses of statin drugs at screening * uncontrolled diabetes or high blood pressure * impaired liver function
treatment of menstrual cycle alterations in adolescents

Conditions: Amenorrhea; Oligomenorrhea; PCOS (Polycystic Ovary Syndrome)

Summary: the aim of the present study is intended to evaluate how treatment with myo-inositol and dioscorea villosa can help improve menstrual cycle irregularities in adolescents, both with and without pcos.

the present study aims to evaluate the possible beneficial effect of a treatment with inofolic hp combined with inofolic phd on the improvement if menstrual cycle alteration in adolescent patients with or without pcos. the molecules chosen for the study are the following: myo-inositol, α-lactalbumin, dioscorea villosa, and vitamin d, are already commercialized as dietary supplements, commonly administered at same dosage provided in the present study, also for prolonged treatments, with no side effects associated.

Eligibility criteria:
inclusion criteria: * adolescent women aged 14-19 years old, with at least 3 years passed after menarche, and oligomenorrhea or amenorrhea exclusion criteria: * primary amenorrhea. * hyperandrogenism due to other factors (i.e. adrenal hyperplasia or cushing syndrome). * hyperprolactinemia or overt hypothyroidism (tsh ≥4). * other hormonal alterations. * ongoing hormonal therapies, including ocps, six months before enrollment. * ongoing pharmacological therapies. * ongoing use of myo-inositol supplement or other source of myo-inositol, or dioscorea villosa, six months before enrollment.

Keywords: myo-inositol dioscorea villosa adolescents