Kornimate/medical-research-clean huggingface dataset:
efficacy study of the use of sequential dfp-dfo versus dfp

Conditions: Beta-Thalassemia; Thalassemia Major

Summary: changes in chelation treatment and transfusion practices, during the past two decades, have dramatically improved the prognosis of thalassemia major patients.deferiprone (dfp) has been compared with deferoxamine (dfo), using different schedules of treatment, in the majority of the 13 clinical trials published between 1990 and 2008.no statistically significant difference was shown between these two interventions during, at most, 18 months of treatment.three randomised trials that compared sequential dfp-dfo treatment versus dfo alone reported controversial results but this could be due to small sample sizes and short treatment duration. in fact, no trial with treatment duration longer than 18 months15, which reported on mortality, adverse events, serum ferritin concentrations, as well as costs has so far been published. this long-term sequential dfp-dfo treatment versus dfp alone treatment trial was conducted to assess the impacts of these chelation treatments on serum ferritin concentrations, mortality, adverse events, and costs in thalassemia major patients.

the trial was designed as a multicentre randomised open-label trial with blinded data management and data analyses, to assess whether either treatment was superior to the other. the trial was performed on behalf of the italian society for the study of thalassemia and haemoglobinopathies (soste). the investigators initiated, carried out, and controlled the trial, which was conducted without influence of the non-commercial sponsor.16

Eligibility criteria:
inclusion criteria: * thalassemia major patients with serum ferritin concentration between 800 to 3,000 ng/ml and were over 13 years of age exclusion criteria: * known intolerance to one of the trial treatments * platelet count \< 100,000/mm3 or or leukocyte count \< 3,000/mm3 * severe liver damage indicated by ascites * heart failure

Keywords: thalassemia major chelation treatment secondary hemochromatosis
validation of the french translation of the scale hscl25 in the diagnosis of depression in primary care

Conditions: Depression

Summary: depression has emotional consequences, social and important business. reaching at least 7.5% of french aged 15 to 85 years. general practitioners are the first professional consulted in terms of frequency of consultations. indeed, in primary care, 10 to 25% of patients with depression that general practitioners are often alone to support and follow. but general practitioners are faced with diagnostic difficulties facing the diagnosis of depression, because if the patient does not engage itself, no tool is validated in france to help them in their diagnosis. however, standardized questionary exist that allow to overcome this difficulty. questionary used in other european countries. among them, the hscl25 scale was selected by a systematic review of literature and a rand ucla type of consensus procedure. this hscl25 scale is the most efficient for the diagnosis of depression in terms of efficiency tool, reproducibility and ergonomics. however, it remains necessary to confirm its validity in terms of the french translation and in terms of efficiency.


Eligibility criteria:
inclusion criteria: * adult (18 and over) consultant in primary care exclusion criteria: * child or young person under 18 * women with a declared pregnancy to prevent puerperal depression whose support is different. * adult consultant to obtain a medical certificate * psychotic patients and\\or requiring immediate care

Keywords: depression primary care general practitioners
sarcopenic obesity as a risk of premature aging

Conditions: Obesity; Sarcopenic Obesity; Aging

Summary: recently, numerous signaling proteins derived from adipose tissue and/or skeletal muscle have been described and are involved in the pathogenesis of obesity and the pathophysiology of aging. current evidence suggests a role for the fgf-klotho system, circulating cell-free dna (cfdna), mir-499, and exosomes not only in the pathophysiology of obesity, but also in the association with sarcopenic obesity (os) and in a accelerated aging. the investigator´s hypothesis is that obesity, especially os, might be the cause of advanced aging, reflected in lower levels of the fgf-klotho system, higher concentrations of cfdna and a change in the profiles of mirnas and exosomes, which could have an impact on risk. cardiovascular and metabolic. for this, a descriptive cross-sectional study is proposed in 50 patients with obesity, who will be classified as os or not, and 25 healthy controls, between 50-60 years old. the determinations are made by the ibiomed of the university of león. to study the evolution of aging markers over a year of follow-up, a second part of the study will analyze the possible differences according to the treatments assigned to each patient in the context of real life (lifestyle changes, drugs, bariatric surgery).

descriptive cross-sectional study in patients with obesity attended in the high-risk obesity consultation of the university assistance complex of león, with a control group of healthy people of the same age group without obesity or cardiovascular risk factors that will be selected among volunteers from the caule and university of leon staff. the second part of the study will be a one-year prospective longitudinal follow-up study of the patients included in the first part of the study.

Eligibility criteria:
inclusion criteria: * people, men and postmenopausal women, aged between 50 and 60 years. diagnosis of central obesity with body mass index greater than or equal to 30 kg/m2 and waist circumference equal to or greater than 102 cm in men and 88 cm in women. control group, of healthy individuals with bmi less than 30 kg/m2 and waist circumference \<102 cm in men and \<88 cm in women, of the same age group and matched according to gender. able of giving informed consent. exclusion criteria: * premenopausal women. kidney disease with glomerular filtration rate less than 60. liver disease with plasma got/gpt/ggt levels greater than x 2 the upper limit of normal. active cancer disease. heart or respiratory failure requiring pharmacological treatment.

Keywords: obesity sarcopenia aging klotho mirna
trial of alvimopan in major spine surgery

Conditions: Constipation

Summary: the investigator has chosen to study the reconstructive spinal surgery patient population because it is believed that the use of alvimopan in these patients at the university of virginia will give the scientific community significant insight into the broader applicability of this drug into other surgical populations, the impact of this drug on the perception of pain (as opposed to simply the consumption of opioids), and its impact on total hospital charges, resource utilization, and functional outcomes.

pain control following major spine surgery is difficult to achieve. opiates are often necessary in high doses, and may be associated with significant side effects. such side effects may include urinary retention, altered mental status, depressed respiratory drive, and constipation, and may lead to reduced nutritional intake in the postoperative period. importantly, post-operative nutrition may impact the incidence of complications following spine surgery.1 alvimopan is a peripheral-acting opiate antagonist designed to decrease the gastrointestinal complications of perioperative systemic opioid administration. pain control following major spine surgery is difficult to achieve. opiates are often necessary in high doses, and may be associated with significant side effects including constipation. alvimopan is a drug approved by the food and drug administration (fda) and is used to help the bowel recover more quickly in patients who are having bowel surgery, so that they can eat solid foods and have regular bowel movements. alvimopan is in a class of medications called peripherally acting mu-opioid receptor antagonists. it works by protecting the bowel from the constipation effects of opioid (narcotic) medications that are used to treat pain after surgery. the purpose of this study is to determine if the use of alvimopan in major spine surgery reduces the time to first bowel movement. by assessing the use of alvimopan in reconstructive spinal surgery patients, researchers hope to give the scientific community insight into the broader use of this drug in other surgical populations, as well as gathering information on the impact of hospital charges and overall post-operative patient satisfaction.

Eligibility criteria:
inclusion criteria: * major spine surgery scheduled as part of clinical care * 18-80 years exclusion criteria: * more than three doses of any opioid within one week of surgery * pregnancy * prisoners * unable to provide consent * emergency surgery * chronic kidney disease stage 5 (gfr \< 15 ml/min) * severe hepatic impairment * recent myocardial infarction (within the last 3 months)
understanding the impact of neighborhood type on physical activity in older adults

Conditions: Cardiovascular Diseases; Heart Diseases

Summary: the purpose of this study is to investigate whether seniors living in neighborhoods that are conducive to walking are more physically active than those living in neighborhoods that are less conducive to walking.

background: despite the recognized benefits of regular physical activity for older adults, people over the age of 65 remain among the most inactive groups of the u.s. population. efforts to understand the factors influencing physical activity in this important group have been limited primarily to demographic and psychosocial domains. the importance of the neighborhood environment in influencing a host of health, behavioral, and psychosocial outcomes has been recognized. however, to date, no systematic investigation of the relationship between objective and subjective environmental factors and objectively measured physical activity levels among older adults has been undertaken. design narrative: this observational study will investigate whether seniors living in neighborhoods conducive to walking are more physically active, after adjusting for socioeconomic status (ses), than those living in neighborhoods less conducive to walking or other forms of physical activity for transportation or recreational purposes. additional questions of interest concern the moderating effects of physical function and the proportion of seniors living nearby on the relationship between environment and physical activity. the study will take advantage of the sampling, recruitment, and data collection methods of an ongoing nih-funded research project aimed at integrating public health and urban planning frameworks in studying the impacts of environmental factors on physical activity levels in younger adults. population-based sampling methods will be used to recruit adults over 65 years of age who are living in more walkable versus less walkable neighborhoods of varying ses levels. participants will be recruited from seattle, washington (n = 600) and baltimore, maryland (n = 600). in addition to objectively measured physical environment (using geographic information systems {gis}) and physical activity levels (using accelerometry), self-reported neighborhood environment, physical activity, and quality of life variables of particular relevance to older adults will be assessed twice during a 12-month period.

Eligibility criteria:
inclusion criteria: * currently living in an apartment, condo, house, or assisted living facility * able to walk more than 10 feet at a time * able to speak and read english * able to complete study surveys (with assistance if necessary) exclusion criteria: * not currently living in one of the areas in which the study will take place
transcutaneous auricular vagus nerve stimulation in patients with narcolepsy type 1

Conditions: Narcolepsy Type 1; Fmri

Summary: the study aimed to examine the efficacy and safety of tvns as a complementary approach for nt1 by conducting a double-blind, randomized, sham-controlled trial. the specific objectives of the study were as follows: to evaluate the effects of complementary tvns on the ability to maintain wakefulness, severity of narcolepsy, mood and quality of life in patients with nt1


Eligibility criteria:
inclusion criteria: 1. age ≥ 12 years old with the ability to understand and complete the self-reported questionnaires 2. the patients met the international classification of sleep disorders third edition (icsd-3) for nt126 3. local residence for more than 3 months 4. willingness to follow the trial plan as scheduled exclusion criteria: 1. history of a clinically defined neurological or sleep disorders other than nt1 2. any psychiatric disorder involving a history of psychosis 3. any chronic condition affecting the ability to read or comprehend written instructions 4. any substances abuse within the past 12 months 5. pregnant or nursing 6. metallic implants or devices contraindicating tvns

Keywords: transcutaneous auricular vagus nerve stimulation
uva1 phototherapy in acral vitiligo

Conditions: Acral Vitiligo

Summary: evaluate the effect of uva1 phototherapy in the treatment of acral vitiligo.


Eligibility criteria:
inclusion criteria: * patients with acral vitiligo. * patients more than 12 years old. exclusion criteria: * patients less than 12 years old. * patients with any other skin diseases or autoimmune diseases. * patients taking medical treatment or phototherapy for vitiligo.
siderophore-labelled positron emission tomography for correlating invasive fungal infections

Conditions: Invasive Fungal Infections

Summary: this trial will demonstrate localised uptake of a radiolabelled fungal component (siderophore) in areas of known specific invasive fungal (aspergillus) infection.

this open label, single centre, proof of concept pilot imaging trial will evaluate technique for the diagnosis of invasive aspergillus infection. it aims to demonstrate uptake of the gallium-siderophore tracer at sites of known proven/probable invasive aspergillus app infection. it will also assess the safety and tolerability of this technique. 10 patients within 2 weeks of proven or probable invasive fungal infection (ifi) diagnosis will be recruited to this study over a period of 12-24 months.

Eligibility criteria:
inclusion criteria: 1. patient has provided written informed consent 2. aged 18 years or older at written informed consent 3. within 2 weeks of proven or probable invasive fungal infection (ifi) diagnosis as per eortc criteria 4. imaging consistent with invasive pulmonary aspergillosis on ct or fdg-pet/ct with lesions at least 8mm in diameter 5. patient is willing and able to comply with the protocol for the duration of the study including scheduled visits such as follow up exclusion criteria: 1. women who are pregnant or lactating. 2. iron infusion within one week prior to scan

Keywords: invasive fungal infections siderophore pet siderophore-labelled position emission tomography 68ga-labelled tafc pet/ct scan aspergillus spp.
mirror feedback, augmented task-specific, impairment-oriented therapy, home practice, stroke rehabilitation

Conditions: Stroke Rehabilitation

Summary: in this study, the investigators will (1) examine immediate and long-term effects of mt priming with task-specific training versus mt-priming with impairment-oriented training, relative to a dose-matched control therapy on motor function, arm activities, quality of life, etc; (2) provide comprehensive evaluations based on the icf model to identify the specific benefits of mt-priming regimens; and (3) explore demographic and clinical characteristics of participants that may predict treatment outcomes.

stroke is one of the major causes of long-term disability. most stroke survivors suffer from arm paresis even in the chronic phase. there is a need to develop novel strategies to augment therapeutic efficacy in stroke rehabilitation. one potential method to enhance treatment efficacy is through the "priming" technique. among all priming techniques, mirror therapy (mt) has been proposed to be a promising method to augment effects of motor re-training. the investigators propose a 3-year research project to determine the effects of mt-priming on augmenting stroke interventions. the investigators select two types of evidence-based neurorehabilitation, the task-specific training and the impairment-oriented training, to be primed by mt based on their unique treatment benefits on restoring arm ability. in addition, the investigators will provide customized home practice corresponding to each type of interventions. specifically, the investigators will (1) examine immediate and long-term effects of mt priming with task-specific training versus mt-priming with impairment-oriented training, relative to a dose-matched control therapy on motor function, arm activities, quality of life, etc; (2) provide comprehensive evaluations based on the icf model to identify the specific benefits of mt-priming regimens; and (3) explore demographic and clinical characteristics of participants that may predict treatment outcomes.

Eligibility criteria:
inclusion criteria: * a first ever-stroke≧3 months * baseline fugl-meyer assessment of upper extremity scale (fma-ue) between 18 to 56 (fugl-meyer et al. 1975) * no excessive muscle spasticity of the affected arm (modified ashworth scale \< 3 at any joints of the affected arm) (bohannon \& smith 1987) * able to follow examiners' commands and study instructions (mini-mental state examination score≧22) (folstein et al. 1975) * no participation in any other experimental rehabilitation or drug studies during period of this project exclusion criteria: * concomitant neurologic, neuromuscular or orthopedic conditions that may interfere with participation of this project * epilepsy within three months
incidence of inadequate pain treatment in ventilated critically ill surgical patients

Conditions: Adult ICU Patients; Pain, Acute

Summary: in sicu, siriraj hospital there were no protocols place for the management of pain. all decisions were made according the attending physicians. there were no information about incidence of inappropriate pain management in sicu due to lack of validated tool for assessment. to date, thai-version of bps and cpot were validated, the incidence of inappropriate pain management in sicu, siriraj hospital should be assessed.


Eligibility criteria:
inclusion criteria: * older than 18 years. * expected duration of mechanical ventilation of more than 24 hours. exclusion criteria: * quadriplegia. * receiving neuromuscular blocking medications. * coma or severe brain injury * neurosurgery/ cvt patients/ trauma patients

Keywords: incidence surgical icu
epileptic psychoses and their link with ictal emotions and consciousness

Conditions: Epilepsy With Partial Onset Seizures With or Without Secondary Generalization; Psychoses; Epilepsy, Generalized

Summary: background : psychiatric comorbidities are common in epilepsy, affecting 50 to 70% of patients, especially when the epilepsy is focal and drug-resistant. among these comorbidities, psychotic disorders (involving hallucinations and delusions) affect 8% of patients - that is, eight times more frequently than in the general population. currently, the links between epilepsy and psychotic disorders are poorly understood and often overlooked by physicians, which impacts the mental health care of patients with epilepsy and leads to underdiagnosis. the aim of this research is to determine whether there are differences in epileptic symptoms between patients with a psychotic comorbidity and those without. study design : the main objective of this research is to better understand whether certain emotional epileptic symptoms are associated with a higher risk of developing psychotic symptoms. the secondary objectives of this study are to investigate whether the level of consciousness during seizures is associated with a higher risk of developing psychotic symptoms. to meet these objectives, the study will include patients who (1) have epilepsy, (2) were hospitalized in the video-eeg unit of the neurology department at central hospital for seizure recording, and (3) underwent a psychiatric evaluation in the context of epilepsy between january 1, 2016, and april 1, 2025. the study will take place at the university hospital center (chru) of nancy, in the neurology department, within the video-eeg unit led by professor louis maillard. the research will involve comparing epileptic symptoms between the group of patients without psychosis and the group of patients with psychosis. data collection will cover the five days of video-eeg hospitalization, along with information from the psychiatric evaluation, for a total duration of approximately one week per year. information for participants: as part of the routine medical care, data is collected in medical records to ensure appropriate follow-up. for the purposes of this research, data from the medical record will be collected. no identifying information (such as name, initials, full date of birth, address, or social security number) will be collected. no additional visits or examinations will be required. patients will not be contacted or asked to provide any new information.


Eligibility criteria:
inclusion criteria: * patients with a confirmed diagnosis of epilepsy * patients hospitalized for at least 5 days for a video-eeg recording * patients with a psychiatric evaluation, conducted between 01/01/2016 and 04/01/2025. * adult patients able to express their opposition to the use of their data. exclusion criteria: * absence of seizure recorded during the video-eeg

Keywords: psychoses of epilepsy postictal psychosis interictal psychosis epilepsy clinical research