Kornimate/medical-research-clean huggingface dataset:
a randomized, double-blind, sham-controlled pilot study to evaluate the treatment efficacy of magnetic eeg/ecg-guided resonance therapy (mert) in college students with adhd

Conditions: ADHD

Summary: this pilot study is a randomized, double-blind, sham-controlled study designed to evaluate the efficacy of magnetic eeg/ecg-guided resonance therapy (mert) in college students with adhd. a total of 40 subjects will be treated.

this pilot study is a randomized, double-blind, sham-controlled study designed to evaluate the efficacy of magnetic eeg/ecg-guided resonance therapy (mert) in college students with adhd. a total of 40 subjects will be treated. twenty (20) subjects will receive active treatment with mert and the other 20 with sham. subjects in each study group will be treated 30 min a day, 5 days a week for 4 weeks. this is known as phase 1. during this study period, subjects and clinicians will be blind to treatment condition. subjects will be recruited from a flyer describing the study. the flyer will be posted at the kortschak center for learning and creativity, the mckay center, and through student counseling services in the engemann student health center. in addition, students who have been diagnosed with adhd and have been seen at one of these facilities for adhd may be provided contact information for the study.

Eligibility criteria:
inclusion criteria: subjects must meet all of the following inclusion criteria to qualify for enrollment into the study: 1. college student 18-25 years of age 2. diagnosed with adhd using the standardized clinical interview and supported by the pearson quotient adhd system and conners adult adhd rating scales (caars) 3. willing and able to adhere to the treatment schedule and all required study visits exclusion criteria: subjects will be excluded from study participation if one of the following exclusion criteria applies: 1. pregnant or trying to become pregnant; negative urine pregnancy test at screening will be required of females of child-bearing potential 2. any antipsychotic or anticonvulsant medication. 3. any type of rtms treatment within 3 months prior to the screening visit 4. intracranial implant (e.g., aneurysm clips, shunts, stimulators, cochlear implants, stents, or electrodes) or any other metal object within or near the head, excluding the mouth, which cannot be safely removed 5. any condition which in the judgment of the investigator would prevent the subject from completing the study 6. any seizure history within the past 10 years 7. eeg abnormalities including indications of risk of seizure, i.e., abnormal focal or general slowing in spikes during the eeg recording 8. unstable medical conditions such as uncontrolled endocrine, hepatic, cardiac, pulmonary and/or renal disorders.
comparison of motion and comfort for thoracolumbosacral orthoses - group 2

Conditions: Back Injuries

Summary: the study will measure and compare range of motion (rom), motion during simulated activities of daily living adl), tissue interface pressure (tip), muscle activation (emg), and trunk stiffness and damping measurements (tsd) for two pairs of back braces: postural tlso (456), and tlso (464).


Eligibility criteria:
inclusion criteria: * bmi \< 40 * english speaking * subjects who have read and signed irb approved informed consent for this study * of appropriate body size for back brace per instructions for use exclusion criteria: * history of back pain or back injury requiring medical care within the previous 12 months * history of spinal surgery, physical or chiropractic therapy of the back * history of spinal spondylosis or osteoporosis * pregnant * currently incarcerated
phase i study with azd2171 in patients with advanced solid malignant tumors and liver metastases

Conditions: Advanced Solid Tumor; Liver Metastases

Summary: single centre recruiting approximately 80 patients who are given a rising single, followed by multiple, ascending oral dose of azd2171, assessing the safety and tolerability of azd2171 in patients with solid tumors and metastatic liver disease.


Eligibility criteria:
inclusion criteria: * provision of written informed consent * male/female, 18 yr or over * who status 0-2 * refractory advanced solid tumor exclusion criteria: * radiotherapy within 4 weeks of starting azd2171 treatment * low haemoglobin level * low platelet or neutrophil counts

Keywords: phase i azd2171 advanced solid tumors
preventing opioid overdose mortality in the united states

Conditions: Opioid Overdose

Summary: this study aims to conduct a randomized controlled trial of 105 syringe services programs (ssps) throughout the united states to understand the effectiveness of a multifaceted, facilitation-based strategy at advancing naloxone implementation effectiveness within ssps. together, these efforts can improve access to naloxone for people at high risk of overdose, thereby improving our nation's response to the opioid overdose epidemic.

we conducted a randomized controlled trial of ssps throughout the united states (us) and us territories. prior to the trial, 342 ssps were known to be operating throughout the us and us territories. our team launched a national survey of syringe services programs (nsssp) in february 2019 of all known ssps operating throughout the united states and its territories, receiving a response from 263 (77%) ssps. among the responding ssps, 94% were implementing overdose education and naloxone distribution (oend), and a total of 105 of ssps implementing oend were recruited into the trial. ssps were randomized in a 1-to-1 fashion to either receive the oend best practice recommendations (comparison ssps) or the oend best practice recommendations along with facilitation-based implementation strategies as detailed below (intervention ssps). we tested the effectiveness of a multifaceted, facilitation-based strategy at advancing oend implementation effectiveness within ssps. implementation effectiveness is 'an organization-level construct that refers to the aggregated consistency, quality, and appropriateness of innovation use (oend) within an organization (ssp).'

Eligibility criteria:
to be eligible, an organization must have: 1) met the definition of an ssp - an organization whose primary function is to distribute drug use supplies to participants to reduce harms associated with drug use, 2) implemented oend for a minimum of 6 months, and 3) completed the national survey of syringe services programs fielded february-july 2019. we excluded organizations such as fire departments or emergency departments of hospitals that offered supply distribution since it would be an ancillary function of these organizations and oend programs that were not part of a syringe services program.

Keywords: implementation science harm reduction
visualization engineering platform for pulse diagnosis of traditional chinese medicine-the research of similar moiré feature analyzing approach based on recurrent neural network to process the measured slip pulse wave-images with chun, guan and chy

Conditions: Slippery Pulse

Summary: the diagnoses processes of traditional chinese medicine (tcm) focus on the following four main types of diagnoses methods consisting of inspection, olfaction, inquiry, and palpation. the most important one is palpation also called pulse diagnosis which is to measure wrist artery pulse by tcm doctor's fingers to detect patient's health state. the pulse diagnosis has three parts, namely 'chun', 'guan' and 'chy', with the location. wrist measurements correspond to different parts of the body's organs. however, the pulse information is analyzed by tcm doctor's pulse diagnoses process, which is picked only a single waveform from a long-term pulse measured process and often discarded the other waveforms contained in the same information, e.g. slip pulse waveform. the research object of this project is to divide the tcm diagnosis patients into two groups, one is the slip pulse group and the other is a flat pulse group, in which the cases are collected at least 50 cases for the first gruop and 30 cases for the second group, individually. the purpose of this project will integrate the tcm doctor's experiences and standardize them in order to construct an effective slip pulse diagnosis system based on visualization engineering platform. it could refine slip pulse diagnoses processes and reduce their diagnoses loading by using the proposed approach during this project. therefore, we will propose a similar moiré feature analyzing approach based on recurrent neural network to process the measured slip pulse wave-images with 'chun', 'guan' and 'chy' in order to prepare this visualization engineering platform. we will measure the waveform images of the three parts of the wrist as 'chun', 'guan' and 'chy' with the moiré feature technology proposed in this project. it mainly extracts the moiré features such as pulse image from numerous measurement 'chun', 'guan' and 'chy' signals, and further analyzes and summarizes them with ai technology. we could extract the pulse characteristics of slip pulse automatically from the many measurement signals and enhance the automatic judging ability of the current pulse instrument to the slip pulse waveform. provide important pulse information to the tcm doctors as an important reference for precision clinical diagnoses.


Eligibility criteria:
inclusion criteria: 1. already sign test consent permit. 2. more than 20-year-old. exclusion criteria: 1. there is a wound or inflammation at the wrist skin measurement.

Keywords: artificial intelligence recurrent neural network wrist artery pulse diagnosis instrument tcm pulse diagnosis feature extraction
relationship of cp and ap

Conditions: Chronic Pancreatitis; Acute Pancreatitis

Summary: the present study aimed to determine the prevalence of ap attacks before the diagnosis of cp and further identified the potential associated factors for ap episodes.


Eligibility criteria:
inclusion criteria: * consequent patients with a diagnosis of cp between january 2010 to december 2015 * informed consents provided exclusion criteria: * autoimmune pancreatitis (aip) * pancreatic cancer diagnosed within 2 years after the diagnosis of cp
buprenorphine maintenance protocol - 1

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to compare the efficacy of buprenorphine versus methadone.


Eligibility criteria:
inclusion criteria: m/f ages 21-50. opiate dependence according to dsm-iv criteria. self-reported use within the last 30 days. agreeable to conditions of study and signed informed consent. exclusion criteria: psychiatric disorder that requires medication therapy. history of seizures. pregnant and /or nursing women. dependence on etoh or benzodiazepines or other sedative/hynotics. acute hepatitis. other medical conditions that deem participation to be unsafe
infectious diseases and movement program: study of the effects of physical activity on hiv infection

Conditions: HIV-1-infection

Summary: exercise and physical activity can have an anti-inflammatory effect, while there is evidence that a sedentary lifestyle could be the basis for the development of systemic inflammation and increased cardiovascular risk. the primary objective is to assess whether regular physical activity is able to induce a decrease in systemic immune-activation in hiv positive patients.

many studies document that exercise and physical activity can have an anti-inflammatory effect, while there is evidence that a sedentary lifestyle could be the basis for the development of systemic inflammation and increased cardiovascular risk. this occurs because a sedentary lifestyle leads to the accumulation of visceral fat, and this is accompanied by an increase in adipokine release and infiltration of adipose tissue by the pro-inflammatory immune cells. furthermore, the imbalance between immune processes and metabolic processes is associated with the development of insulin resistance, atherosclerosis and neurodegeneration. the primary objective is to assess whether regular physical activity is able to induce a decrease in systemic immune-activation in hiv positive patients. to evaluate this hypothesis, the following parameters will be analyzed: evaluation of immune-activation levels, of metabolic parameters, of cardiac function, of immuno-virological set-up, of dietary intake and of physical performance indices in hiv-positive patients with a sedentary lifestyle; these data will be compared with the values measured in the same hiv positive population with a sedentary lifestyle after three months of regular physical activity.

Eligibility criteria:
inclusion criteria: 1. patients aged 18-60 years 2. patients who have signed informed consent 3. hiv positive patients 4. patients who have performed a sports medical examination with ecg and are suitable for non-competitive physical activity. exclusion criteria: 1. anemia, pregnancy or any other contraindication to blood sampling and sports activity 2. patients suffering from cardiomyopathies and ischemic heart disease
effect of adaptive servoventilation on cardiac function in chronic heart failure and cheyne-stokes respiration

Conditions: Chronic Heart Failure; Central Sleep Apnea; Cheyne-Stokes Respiration

Summary: sleep disordered breathing is common in patients with chronic heart failure. adaptive servoventilation is a novel method of treatment central sleep apnoea, especially associated with cheyne-stokes-respiration. the aim of the study is to investigate effect of adaptive servoventilation on cardiac function, exercise tolerance and quality of life in patients with chronic heart failure.


Eligibility criteria:
inclusion criteria: * chronic heart failure with ejection fraction ≤45% * optimal medical treatment for at least 1 month * clinical diagnosis of cheyne-stokes respiration exclusion criteria: * unstable heart failure * stroke * transient ischemic attack in last 6 months * pacemaker, cardioverter-defibrillator or resynchronization device implanted less than 6 months before study entrance * severe chronic obstructive pulmonary disease
randomized controlled trial for immunogenicity and safety evaluation of bivalent types 1 and 3 oral poliovirus vaccine

Conditions: Poliomyelitis

Summary: type 2 component of oral poliovirus vaccine is slated for global withdrawal through a switch from trivalent oral poliovirus vaccine (topv) to bivalent oral poliovirus vaccine (bopv) for preventing paralytic polio caused by circulating vaccine-derived poliovirus type 2. we aimed to assess immunogenicity and safety profile of six vaccination schedules with different sequential doses of inactivated poliovirus vaccine (ipv), topv, or bopv.

a randomized controlled trial was conducted in china in 2015. after informed consent was obtained from a parent or legally acceptable representative, healthy newborn babies were randomly allocated to one of six groups: cipv-bopv-bopv, cipv-topv-topv, cipv-cipv-bopv, cipv-cipv-topv, cipv-cipv-cipv, and topv-topv-topv. the key eligibility criteria were: full-term birth (37-42 weeks of gestation), birthweight ≥2·5 kg, no obvious medical disorders and no polio vaccination. infants received following three doses sequentially with 4- 6 weeks interval after collecting blood sample: cipv-bopv-bopv, cipv-topv-topv, cipv-cipv-bopv, cipv-cipv-topv, cipv-cipv-cipv, and topv-topv-topv; and will be proactively followed up for observing adverse events after the first dose and 30 days after all doses. antibodies of type 1, 2, and 3 poliovirus were tested 30 days after the third dose. the primary study objective was to investigate immunogenicity and safety profile of different vaccine schedules, evaluated by seroconversion, seroprotection and antibody titre against poliovirus types 1, 2, and 3 in the per-protocol population.

Eligibility criteria:
inclusion criteria: * eligible participants were healthy full-term (37-42 weeks) infants aged 60-90 days who weighed more than 2·5 kg at birth with no obvious medical disorders, no polio vaccination, no immunoglobulin vaccinated, no other attenuated vaccine immured in the past 14 days and no other inactivated vaccine immured. exclusion criteria: * participants were excluded if meet one or more of following criteria: were or were at risk of immunodeficiency, severe allergic reaction, acute fever and infectious diseases, severe chronic diseases, family history of allergies, convulsions, seizures, encephalopathy and psychiatric diseases, oral steroids at least 14 consecutive days in the past month, axillary temperature equal or greater than 38·0°c in the past three days, diarrhea (defection frequency equal or greater than three times per day) in the past seven days, and participated in other drug clinical trials.

Keywords: immunization vaccine schedule poliomyelitis polio oral polio vaccine inactivated polio vaccine
mindfulness-based short intervention for seniors - decentering effects on cognitive functions and psychological distress

Conditions: Old Age; Debility; Psychological Distress; Cognitive Change

Summary: the present study examined the effect of a short mindfulness-based intervention emphasizing a 'decentering' component on elderly seniors. methods: 30 community seniors (mage= 74.7) performed either 'decentering' intervention, guided imagery intervention, or control care as usual. the 8-week interventions included weekly 20-minute sessions and daily 10-minute home practice. participants underwent a cognitive and emotional assessment before and after the interventions, which included filling out questionnaires and performing the simon task. trial registration: the study follows the principles of the declaration of helsinki, approved by the committee in beer-yaacov hospital, israel (number 579) on 24 oct. 2017.


Eligibility criteria:
inclusion criteria: * age 65 and above * membership in the study's specific enrollment community centers * scoring 24 and above in the mini-mental state examination (mmse). exclusion criteria: * age under 65 * not being a member in the study's specific enrollment community centers * scoring under 24 in the mini-mental state examination (mmse).

Keywords: elderly mbsr cognitive functions psychological status
analysis of cytokine expression pattern in systemic sclerosis

Conditions: Systemic Sclerosis

Summary: by contrast to other proinflammatory cytokines which are found up-regulated in the skin of patients with psoriasis, atopic dermatitis or systemic sclerosis, il-34 is the only cytokine that undergoes down-regulation. this finding is interesting regarding the description of il-34 as an immunosuppressive cytokine. in this study, the expression and the role of interleukin-34 (il-34) will be investigated in the physiopathology of systemic sclerosis.

the mechanisms involved in the physiopathology of systemic sclerosis (ssc) are not fully understood, particularly the pattern of cytokine expression in the skin of ssc patients. these cytokines are known to play a central role in the regulation of numerous inflammatory diseases and, among them, il-34 is the only cytokine which has been found to be down-regulated in other skin inflammatory disorders such psoriasis or atopic dermatitis. il-34 has been described as an immunosuppressive cytokine, and our preliminary results show that il-34 is active on fibroblasts, a key cell that undergoes dysfunction in ssc. thus, we are willing to explore its expression profile in the skin of ssc patients and its potential role in the physiopathology of the disease. for this study, we will analyze il-34 mrna levels in the skin and the plasma of ssc patients by comparison to healthy patients. thirty patients will be included in the internal medicine unit of the chu de poitiers during a single visit, in the frame of their medical follow-up, to collect two skin biopsies and 5 ml of blood after obtaining their informed consent. the expression of il-34 will also be investigated at the protein level by immunostaining on skin sections and by elisa (skin protein lysates and plasma). moreover, the expression of other proinflammatory cytokines will be investigated both at the mrna and protein levels.

Eligibility criteria:
inclusion criteria: * age ≥ 18 year-old * diagnosis of systemic sclerosis according to acr/eural 2013 criteria. * skin sclerosis reaching an area over finger bases of hands and feet * free subject, without neither guardianship, wardship nor subordination * patient with social security * informed and signed consent by the patient after clear and loyal information on the study exclusion criteria: * age \< 18 year-old * patients that do not fit the acr/eural 2013 criteria * patients under immunosuppressive treatment * sclerosis limited to fingers of hands and feets. * patient without social security * pregnant and nursing women

Keywords: cytokine skin inflammation
efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for bipolar depression

Conditions: Bipolar Depression

Summary: the aim of this study is to evaluate the feasibility and efficacy of deep transcranial magnetic stimulation (dtms) as an add-on treatment for bipolar depression. meanwhile, we aim to evaluate the effect of dtms on cognitive function of bipolar depressive patients. we hypothesize dtms would improve depressive symptoms and cognitive function in bipolar disorder.

this is a randomized, double-blind, sham-controlled study to detect the effect of dtms for treatment of bipolar depression. 100 participants were randomly assigned 1:1 to dtms group or sham-control group. for both active and sham group, daily dtms sessions were scheduled in a 5-day sequence for four consecutive weeks, and each session lasted 20minutes. based on the original and stable medication, the active stimulation consisted of 55 18 hz, 2 s trains at 120% mt intensity, with a between-train interval of 20 s (1980 pulses per day or 39 600 pulses per treatment). the sham stimulation was performed using the same procedures, with the sham coil. scale assessments are performed at baseline, week 2, week 4 and week 8. collection of blood took place at baseline, week 4 and week 8.

Eligibility criteria:
inclusion criteria: confirmed diagnosis of bipolar depression; * met standardized criteria for failure to achieve remission from pharmacological treatment in the current illness episode; * pharmacological treatment maintained unchanged for the four weeks preceding rtms application； * able to read, verbalize understanding and voluntarily sign the informed consent form prior to performance of any study-specific procedures or assessments exclusion criteria: * previous treatment with rtms; * ferromagnetic material close to the head; * cardiac pacemaker and/or implanted electronic device; * the presence of neurological disorders (uncontrolled epilepsy, previous significant head injuries, brain surgery); * pregnancy or lactation; * significant medical and/or psychiatric comorbidities; * substance abuse in the last three months (not including caffeine or nicotine); * acute psychosis; * acute suicidality; * patient refuses to sign consent for participation in the study