Kornimate/medical-research-clean huggingface dataset:
evaluation of chronotype and central sensitization in patients with fibromyalgia syndrome

Conditions: Chronotype; Fibromyalgia Syndrome

Summary: the aim of study is to examine the chronotype preferences of patients with fibromyalgia syndrome and the relationship between central sensitization and chronotype, and to examine its relationship with pain intensity, disability and quality of life.

fibromyalgia syndrome (fms); it is a syndrome characterized by chronic pain occurring in more than one part of the body and accompanied by fatigue, sleep disturbance, impairment in quality of life and daily functionality. although fms is seen in different age groups, it is most common in middle-aged women. fms is classified as central sensitization syndrome, in which there is an abnormal response to painful stimuli and the processing of nociceptive stimuli in the central nervous system. in patients with fms, pain may cause sleep disturbances such as non-restorative sleep or difficulty initiating or maintaining sleep. it is estimated that 65-99% of patients with fms experience sleep disorders. circadian rhythms reflect 24-hour physiological and behavioral cycles within each individual. based on individual differences in the timing of these innate rhythms, individuals can be divided into 3 phenotypes (i.e., chronotypes): morning type (m-highest level of alertness in the morning), evening type (e most active in the evening), and intermediate type (i-neither m nor e). chronotype is explained by both genetic and environmental factors and can be considered a fairly robust trait throughout adulthood. a study assessing 1548 people with fms with an online survey including questions about sleep quality, well-being, pain, chronotype and fms impact shows that late chronotypes are more affected by fibromyalgia. in another study conducted in 2019, patients with fms were grouped according to chronotype preferences and showed that there was a strong relationship between fms severity and poor quality of life in evening individuals. the aim of study is to examine the chronotype preferences of patients with fibromyalgia syndrome and the relationship between central sensitization and chronotype, and to examine its relationship with pain intensity, disability and quality of life.

Eligibility criteria:
inclusion criteria: * being diagnosed according to acr 2016 fibromyalgia syndrome diagnostic criteria continuing complaints for at least 3 months exclusion criteria: * neurological and inflammatory diseases pregnancy malignancy

Keywords: fibromyalgia syndrome chronotype central sensitization disability quality of life
ischemia reperfusion: prostaglandins and antioxidants

Conditions: Ischemic Reperfusion Injury

Summary: the purposes of this study are two-fold. the first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. the second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?


Eligibility criteria:
inclusion criteria: * healthy males * healthy females exclusion criteria: * smokers * cardiovascular disease * peripheral vascular disease * neurological deficits * diabetes type i or ii * pregnant women * adverse reactions to ibuprofen
thyromental height test as a new method for prediction of difficult intubation in obese patients

Conditions: Intubation, Intratracheal; Obesity; Predictive Value of Tests

Summary: the main objective of this trial is to assess the clinical usefulness of thyromental height test (tmht) in prediction of difficult intubation in obese patients scheduled for elective surgical procedures. the secondary aim is to evaluate usefulness of other commonly used predictive tests associated with difficult intubation in obese patients.

successful and fast intubation are crucial for the safety of general anaesthesia. failed intubation and acute hypoxia remain among the major contributing factors of anaesthesia related deaths. difficult intubation prevalence in literature is very inconsistent and varies between 1.5-20% of cases in general population, to even 50% in obese thai population. obesity remains a challenging problem in perioperative care. it is assumed that the airway access may be restricted due to anatomic changes resulting from excess body weight. there are factors like diagnosed obstructive sleep apnoea or large neck circumference that also relate to occurrence of difficult intubation in obese patients. there is a number of anthropometric scales and tests used for predicting difficult intubation in obese patients. however, none of them appears to be sensitive and specific enough to effectively predict difficult intubation. recently, simple and non-invasive test predicting difficult intubation was introduced-thyromental height test (tmht). it shows promise as a more effective substitution for frequently cited anthropometric measures. it is based on the height between the anterior border of the thyroid cartilage and the anterior border of the mentum, measured while the patient lies in the supine position with closed mouth. the main objective of this trial is to assess the clinical usefulness of tmht in prediction of difficult intubation in obese patients scheduled for elective surgical procedures. the secondary aim is to evaluate usefulness of other commonly used predictive tests associated with difficult intubation in obese patients.

Eligibility criteria:
inclusion criteria: * qualification for elective surgical procedures, requiring general anaesthesia, direct laryngoscopy and intubation * consent for participation in the trail * age ≥18 years * bmi ≥30 kg/m2 exclusion criteria: * bmi ≤30 kg/m2 * patients overweight due to ascites or tumor * emergency procedures * visible anatomic abnormalities * patients scheduled for awake fibreoptic intubation * intubation failure * lack of consent for participation in the trail

Keywords: difficult intubation obesity thyromental height test
metformin for the treatment of microvascular dysfunction after gestational diabetes

Conditions: Gestational Diabetes

Summary: the purpose of this investigation is to examine the mechanisms mediating vascular dysfunction in women who have had gestational diabetes and how metformin may be a valuable treatment tool to improve microvascular function in these women before the onset of disease.

women with a history of gestational diabetes mellitus (gdm) are at a 2-fold greater risk for the development of overt cardiovascular disease (cvd) following the effected pregnancy. while subsequent development of type ii diabetes elevates this risk, prior gdm is an independent risk factor for cvd morbidity, particularly within the first decade postpartum. gdm is associated with impaired endothelial function during pregnancy and decrements in macro- and microvascular function persist postpartum, despite the remission of insulin resistance following delivery. collectively, while the association between gdm and elevated lifetime cvd risk is clear, and available evidence demonstrates a link between gdm and vascular dysfunction in the decade following pregnancy, the mechanisms mediating this persistent dysfunction remain unexamined. the purpose of this investigation is to examine the mechanisms mediating vascular dysfunction in women who have had gestational diabetes and how metformin may be a valuable treatment tool to improve microvascular function in these women before the onset of disease. this study will give rise to a new line of research that will center around the goal of improving lifetime cardiovascular outcomes in women with a history of gdm. in this study, the investigators use the blood vessels in the skin as a representative vascular bed for examining mechanisms of microvascular dysfunction in humans. using a minimally invasive technique (intradermal microdialysis for the local delivery of pharmaceutical agents) they examine the blood vessels in a dime-sized area of the skin in women who have had gdm. local heating of the skin at the microdialysis sites is used to explore differences in mechanisms governing microvascular control. as a compliment to these measurements, the investigators also draw blood from the subjects and isolate the inflammatory cells.

Eligibility criteria:
inclusion criteria: * ≥12 weeks and ≤5 years postpartum * history of gdm or healthy pregnancy exclusion criteria: * prediabetes or diabetes (hba1c ≥5.7%) * current tobacco use * cardiovascular or metabolic disease * cardiovascular or metabolic medication * history of hypertension during pregnancy * current pregnancy

Keywords: gestational diabetes postpartum vascular
a study of mk-8527 in healthy lactating female participants (mk-8527-009)

Conditions: Healthy; HIV Pre-exposure Prophylaxis

Summary: the goal of this study is to learn how mk-8527 moves through the healthy person's body over time. researchers will measure for the amount of mk-8527 in breast milk that the baby will receive at many time points.


Eligibility criteria:
inclusion criteria: the key inclusion criteria include but are not limited to the following: * is at least 6 weeks postpartum at the time of administration of study intervention, following the delivery of a healthy singleton neonate * is willing and able to express breast milk at least twice daily for at least 120 hours after enrollment * is willing to discontinue breastfeeding from the time of administration of study intervention until at least 6 weeks following the administration of study intervention. this includes the avoidance of both directly breastfeeding and the administration of breast milk pumped during the above-specified time frame to the infant. is willing to confirm with the site that the infant is able to bottle feed (breast milk) prior to day 1 and that alternative nutrition (i.e., previously stored breast milk or infant formula) is available for feeding the infant through the 6-week post dose period exclusion criteria: the key exclusion criteria include but are not limited to the following * has a history of clinically significant endocrine, gastrointestinal (gi), cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, psychiatric, or major neurological (including stroke and chronic seizures) abnormalities or diseases * had mastitis within 30 days prior to administration of study drug * has a positive pregnancy test at the time of screening or prior to treatment allocation
domperidone expanded access program for oncology patients with gastroparesis who have failed standard therapy

Conditions: Oncology Patients With Gastroparesis

Summary: gastroparesis is a digestive disorder in which motility of the stomach is either slowed or absent. the gastroparesis prevents normal digestion from occurring. the purpose of this study is to provide oral domperidone offered under the u.s. food and drug administration (fda) expanded access program, to patients that, based on the treating doctor's assessment, could benefit from , a prokinetic effect for the relief of refractory gastroesophageal reflux disease with upper gastrointestinal (gi) symptoms, gastroparesis, and chronic constipation.

at the discretion of the investigator, 10-30 mg of oral domperidone is administered qid (four times a day). the investigator will be starting patients on 10 mg four times a day for 2 weeks, then increase to 20 mg four times a day for 2 weeks. the participant will be evaluated at each time point. if the participant still is not having relief of symptoms the investigator may increase their dose to 30mg four times a day.

Eligibility criteria:
inclusion criteria: 1. male or female 2. age 18 and older 3. symptoms or manifestations secondary to gerd (e.g., persistent esophagitis, heartburn, upper airway signs or symptoms or respiratory symptoms), gastrointestinal motility disorders such as nausea, vomiting, severe dyspepsia or severe chronic constipation refractory to standard therapy. 4. patients must have a comprehensive evaluation (physical exam and also may include egd, gastric emptying study, as clinically necessary) to eliminate other causes of their symptoms. 5. patient has signed informed consent for the administration of domperidone that informs the patient of potential adverse events including: * increased prolactin levels * extrapyramidal side-effects * breast changes * cardiac arrhythmias including qt prolongation and death exclusion criteria: history of, or current, arrhythmias including ventricular tachycardia, ventricular fibrillation and torsade des pointes. patients with minor forms of ectopy (pacs) are not necessarily excluded. 1. clinically significant bradycardia, sinus node dysfunction, or heart block. prolonged qtc (qtc\> 450 milliseconds for males, qtc\>470 milliseconds for females). 2. clinically significant electrolyte disorders. 3. gastrointestinal hemorrhage or obstruction 4. presence of a prolactinoma (prolactin-releasing pituitary tumor). 5. pregnant or breast feeding female 6. known allergy to domperidone
braf v600e and redifferentiation therapy in radioiodine-refractory papillary thyroid cancer

Conditions: Thyroid Cancer

Summary: papillary thyroid cancer (ptc) is the most common neoplasia in the thyroid gland. the combination of surgery, followed by radioiodine therapy (rit) and thyroid-stimulating hormone (tsh) suppressive therapy is usually a curative option for differentiated thyroid cancer (dtc). although dtc has a good prognosis generally, it is problematic when dedifferentiation is suspected and radioiodine refractoriness presumed. one possible therapy option for redifferentiation is the pretreatment with retinoids. from 2008 to 2014 there were 13 patients with ptc who were treated with retinoids after thyroidectomy before a further course of radioiodine. a recent study has shown that the efficacy of selumetinib, another option for redifferentiation depends on the mutational status of the treated patient. in this retrospective study the investigators looked for a similar association between braf v600e and redifferentiation therapy with retinoids. as retinoids have fewer side effects compared to tki, it is worth performing studies to assess the importance of genetic marker for the response and to estimate the chances of this specific patient collective. braf v600e seems to be associated with better long-term response after redifferentiation therapy with 13-cis ra in rai-r ptc. therefore, evaluation of braf mutational status prior to redifferentiation therapy could be beneficial for predicting response.


Eligibility criteria:
eligible criteria for radioiodine-refractory patients included: * ptc * no response to former rit * decrease or loss of initial sufficient ri-uptake * redifferentiation therapy with 13-cis-ra * available ffpe tissue. eligible criteria for radioiodine-sensitive patients included: * ptc * cured after a maximum of two rit * no redifferentiation therapy necessary * available ffpe tissue. exclusion criteria * dtc other than ptc * patients lost to follow-up * other redifferentiation therapy than retinoids * anaplastic or medullary thyroid cancer * benign thyroid disease, no available ffpe tissue * more than two rits in the control group * insufficient clinical information.
international multicentre prevalence study on sepsis

Conditions: Severe Sepsis; Septic Shock

Summary: to mark 10 years of the surviving sepsis campaign (ssc), and timed to coincide with world sepsis day, on september 13, 2013, the ssc, esicm and sccm will be conducting an international point prevalence study of severe sepsis and septic shock. the goal of this project is to determine the world wide burden of severe sepsis and define current practices of sepsis care internationally. the study is a simple data collection exercise for patients presenting with either severe sepsis or septic shock on world sepsis day.

de---identified patient---level data will be collected on patients presenting to a participating intensive care unit or emergency department with severe sepsis or septic shock over a 24 hour period from 00:00 to 24:00 november 07, 2013. de---identified data that is already collected as part of routine clinical care will be collected for this study. data to be collected includes hospital and icu characteristics, patient characteristics, severity of illness, and adherence to ssc bundle elements and mortality. it will take between 30---60 minutes to collect and enter data for each patient admitted with severe sepsis or septic shock over the 24 hours study period.

Eligibility criteria:
inclusion criteria: to be eligible patients must have all of the following: * must be admitted or transferred to either the ed or an intensive care unit. * have a high clinical suspicion of an infection * have sepsis as defined by an infection together with two or more sirs criteria * evidence of acute organ dysfunction and/or shock. exclusion criteria: * patients less than 18 years of age * patients in whom the sepsis has been present from before the beginning of the study period * any patients previously included in the study during the same study period

Keywords: sepsis severe sepsis septic shock infection organ dysfunction quality improvement
the effect of pranayamic techniques on obstructive sleep apnea syndrome

Conditions: Obstructive Sleep Apnea Syndrome

Summary: study was planned to investigate the effect of pranayama on dyspnea, daytime sleepiness, cognitive function, quality of life, activities of daily living, functional exercise capacity, physical activity level, sleep quality, fatigue, musculoskeletal pain, depression and anxiety in osas.

thirty-four osas patients meeting the inclusion criteria will be randomized into 2 groups as pranayama and control groups. the pranayama group will practice pranayama on their own for 8 weeks, 7 days a week, 3 times a day for 15 minutes. in addition, he will perform a single 15-minute session 3 days a week online under the supervision of a physiotherapist. the control group will not receive any intervention. dyspnea sensation before and after the training modified medical research council dyspnea scale, daytime sleepiness epworth sleepiness scale, cognitive function montreal cognitive assessment scale, quality of life short form-36, turkish adaptation of nottingham health profile questionnaire and functional outcomes of sleep questionnaire, activities of daily living london chest activities of daily living scale, functional exercise capacity 30 seconds sit and stand test, physical activity level international physical activity questionnaire-short form, sleep quality pittsburgh sleep quality index, fatigue status fatigue severity scale, depression and anxiety hospital anxiety and depression scale, musculoskeletal system pain will be assessed with the nordic musculoskeletal questionnaire.

Eligibility criteria:
inclusion criteria: * patients diagnosed with mild to moderate obstructive sleep apnea syndrome. exclusion criteria: * using a mandibular advancement device * regularly using hypnotic drugs * have a metabolic disease (eg diabetes, hypothyroidism, obesity) * have hypertension * have malignancy * have epilepsy * have heart failure * have copd * have asthma * neurological, psychological, cooperative problems * having a history of maxillofacial surgery
transition of care for patients with hirschsprung disease and anorectal malformations

Conditions: Anorectal Malformations; Transition; Quality of Life; Hirschsprung Disease

Summary: transition from paediatric to adult health care is crucial for preventing deterioration of chronic diseases. at present, transitional care (tc) is not established for patients with the hirschsprung disease (h) and anorectal malformations (arm). to set up a program for tc and to treat persisting symptoms in adults, data on outcome in adult patients are needed. at present such data are very limited. therefore, we want to investigate clinical and prom in h and arm adolescents and adults. a cross sectional study in all h and arm patients operated in norway from 1970-2000 and in all adolescents operated at oslo university hospital from 2002-2006 will examine somatic, psychosocial and mental health, and quality of life (qol). in children operated for h and arm a large body of evidence shows that bowel problems, reduced qol and impaired psychosocial and mental health are common. there are papers on sexual and urological impairment in these patients, but large studies on the topic is missing. it is a general assumption among paediatric surgeons that both somatic and mental health problems related to h and arm improve during adolescence and adult life. therefore, no standardized guidelines for tc in these patients have been established. interestingly, very few studies have actually examined h and arm patients beyond adolescence. reports from patient organizations showing significant long-term sequels and inadequate understanding of the unique problems of h and arm patients among health professionals treating adults. hypothesis:h and arm adults and adolescents have bowel, urinary and sexual difficulties and reduced qol, psychosocial and mental health. h and arm adults receive insufficient treatment of their chronic congenital disease. h and arm patients with syndromes have particularly bad functional outcome. anal dilatations and repeated rectal enemas have a negative impact on adolescent psychosocial and mental health. main aim: acquire knowledge about long-term bowel, urinary and sexual function, qol and psychosocial and mental health in adult and adolescent h and arm patients. results: from this large study of h and arm patients will have significant influence on treatment and follow-up, both nationally and internationally. since very few countries except the nordic countries have the possibility to follow patients with congenital malformations into adulthood, it is important that studies like this are done.


Eligibility criteria:
inclusion criteria: alle patients with hirschsprung and anorectal malformation exclusion criteria: none
role of immunoscore® in stage ii-iii colorectal cancer

Conditions: Colon Adenocarcinoma

Summary: the proposed study is a bidirectional analytical study, composed of a retrospective and a prospective cohorts. patients with stage ii - iii colorectal cancer undergoing oncological surgery will be analyzed. the study will include a convenience sample of 100 individuals. fifty cases will be included retrospectively and fifty prospectively. the study aims to evaluate the benefit of using the immunoscore test as a predictor of recurrence in patients with operated stage ii-iii colon tumors. it will also be evaluated the impact on oncologic decision and costs.


Eligibility criteria:
inclusion criteria: 1. anatomopathological diagnosis of colorectal adenocarcinoma 2. stage ii - iii (ajcc 8th edition) 3. patient undergoing surgery with curative intent exclusion criteria: 1. current or previous diagnosis (within the last 5 years) of another invasive primary malignant neoplasm, with the exception of non-melanoma skin neoplasm 2. presence of distant metastatic disease evidenced in imaging tests

Keywords: colorectal cancer colon carcinoma immunoscore immune response predictive markers prognostic markers tumour microenvironment