Kornimate/medical-research-clean huggingface dataset:
topical cyclosporine-a for management of epiphora

Conditions: Epiphora

Summary: to investigate the clinical outcomes and tolerances of cyclosporine a (csa) in treating epiphora in eyes with acquired punctum stenosis

a prospective study included patients who were referred to our outpatient clinics in farwanyia hospital, kuwait during the period between july 2019 and january 2020, having symptomatic epiphora associated with severe acquired lower punctal stenosis. patients were treated with topical 0.05% csa on twice daily dose with topical preservative free artificial tears q.i. d. patients were followed up monthly for at least 3 months by epiphora grading, fluorescein dye disappearance test (fdt) and evaluating the patient satisfaction

Eligibility criteria:
inclusion criteria: * adult patients of either sex * had a diagnosis of epiphora that persisted more than three months both indoors and outdoors * grade 0 punctal stenosis * did not adequately respond to artificial tears, topical corticosteroids and topical antibiotics or in whom corticosteroids were discontinued due to their side effects. exclusion criteria: * congenital punctal obstruction * edematous puncti * allergic conjunctivitis * history of dacryocystitis, * inflammatory systemic diseases * any previous chemotherapy treatment, and local irradiation. * other causes of epiphora, lid laxity, entropion, and ectropion * lid malposition, canalicular or nasolacrimal sac or duct obstruction * previous eyelid or lacrimal drainage surgery * untreated conjunctivitis or blepharitis

Keywords: cyclosporine a epiphora punctal stenosis
ledipasvir/sofosbuvir fixed-dose combination for 12 weeks in participants with chronic genotype 2 hcv infection

Conditions: Hepatitis C Virus Infection

Summary: the primary objectives of this study are to evaluate the antiviral efficacy of therapy with ledipasvir/sofosbuvir (ldv/sof) fixed-dose combination (fdc) and to evaluate the safety and tolerability of ldv/sof fdc and sofosbuvir (sof) + ribavirin (rbv) in participants with chronic genotype 2 hepatitis c virus (hcv) infection.


Eligibility criteria:
key inclusion criteria: * chronic genotype 2 hcv-infected males and non-pregnant/non-lactating females * aged 20 years or older * treatment naive or treatment experienced * at least 20 subjects will have child-pugh-a compensated cirrhosis. in cohort 2, participants must be ineligible or intolerant of rbv. key exclusion criteria: * previous exposure to an ns5a or ns5b inhibitor * infection with hepatitis b virus (hbv) or human immunodeficiency virus (hiv) * pregnant or nursing female or male with pregnant female partner note: other protocol defined inclusion/exclusion criteria may apply.
endoscopic full-thickness resection of residual colorectal lesions - the fire study

Conditions: Adenoma

Summary: adenomatous lesions of the colon are premalignant lesions which have the potential to develop cancer. therefore adenomas should be resected endoscopically (endo- mucosa resection, emr). emr is conducted after submucosal injection of saline which allows to lift the desired lesion prior to resection. in some cases emr is complicated due to incomplete or failed lifting after the injection of saline. this so- called "non- lifting" sign is a predictor for malignancy of the lesion. difficult- to- lift polyps are also difficult- to- resect. a higher proportion of these lesions fail to be resected completely using the emr technique. alternatively, an over- the- scope full- thickness resection device (ftrd) can be used in order to resect colonic lesions. the ftrd technique has been described elsewhere (schmidt et al. gastroenterology 2014; 147: 740-742.e2). no comparative data exists until now on the performance of ftrd resection compared to standard emr resection of difficult- to- resect colon adenomas. in this study the investigators aim to compare the success of ftrd versus emr of difficult- to- resect adenomatous lesions (≤ 20 mm).


Eligibility criteria:
inclusion criteria: * patients ≥ 18 years * adenomatous lesion 10-20 mm in size with expected difficulties regarding emr (e.g. "non- lifting sign") exclusion criteria: * patients \< 18 years * lesions \> 20 mm in size * high risk carcinomas ("deep submucosal carcinoma") * american society of anesthesiologists (asa) class iv and higher

Keywords: adenoma emr ftrd non- lifting colon
validation of the french version of the drooling impact scale in a pediatric cerebral palsy population

Conditions: Cerebral Palsy; Drooling

Summary: the aim of this study is to present the french translation of the drooling impact scale (dis-f) and to explore its validity, reliability and responsiveness to change in a group of children with cerebral palsy (cp)

drooling in children with cp is likely underestimated and under treated. it is an over-handicap for these children, because it causes many complications and may lead to a decline in self-esteem and to social isolation, altering the quality of life for patients and families. the therapeutic arsenal for the management of drooling includes rehabilitation techniques, oral drug treatments, local treatments or surgical treatments whose effectiveness is variable. in order to evaluate the efficacy of these therapies, standardized and valid assessment tools must be used. the drooling impact scale (dis) developed by dr. sue reid's team in melbourne in 2008, shows good validity and sensitivity to change, especially after botulinum toxin injection. it is commonly used in english-speaking studies, but no validation in french is available yet. the aim of this study is to present the french translation of the drooling impact scale (dis-f) and to explore its validity, reliability and responsiveness to change in a group of children with cp.

Eligibility criteria:
inclusion criteria: * cerebral palsy * hypersialorrhea * no change in content and frequency of speech therapy for three months following baseline * at least 1 out of 2 parents must have a clear understanding of french language * oral consent exclusion criteria: * no clear understanding of french language
phase 2 trial of td 6424 (telavancin) versus standard therapy for complicated gram positive skin and skin structure infections (gram positive csssi)

Conditions: Infections, Gram-Positive Bacterial; Abscess; Burns; Cellulitis; Ulcer; Wound Infections

Summary: serious infections caused by resistant bacteria are becoming more of a medical problem throughout the world. one of the ways to deal with this problem is to develop new drugs that can control these bacteria. this study will measure how well td-6424 (telavancin) can control infections and whether this drug can be safely given to patients.


Eligibility criteria:
inclusion criteria: * patients must have a diagnosis of one of the following complicated skin and skin structure infections with either a suspected or confirmed gram positive organism as the major cause of the infection: * major abscess requiring surgical incision and drainage * infected burn (see exclusion criteria for important qualifications) * deep/extensive cellulitis * infected ulcer (see exclusion criteria for important qualifications) * wound infections * patients must be expected to require at least 4 days of intravenous antibiotic treatment exclusion criteria: * previous systemic antibacterial therapy (with the exception of aztreonam and metronidazole) for \> 24 hours within 7 days prior to the first dose of study medication unless the pathogen was resistant to prior treatment or the patient was a treatment failure (no clinical improvement after 3 days). * burns involving \> 20% of body surface area or third degree/full thickness in nature, diabetic foot ulcers, ischemic ulcers/wounds, necrotizing fasciitis, gas gangrene, or mediastinitis.
effects of scalp nerve blocks on systemic inflammation

Conditions: Meningiomas

Summary: patients undergoing meningeoma resection surgery will be randomly assigned to two groups. one group will receive scalp nerve blocks with 0.5% ropivacaine, whereas the other group will receive scalp nerve blocks with 0.9% saline after anesthesia induction and before skull-pin insertion. serum levels of tnf-α、il-6 and il-1β will be measured and compared at before surgery, 1h, 24h and 72h after surgery, respectively. vas score, dosage of pain-control medicine and nrs score at the first three days after surgery, ratio of intracranial infection within 30d after surgery, and total hospitalization days and medical expenditure will also be recorded and compared between the two groups.


Eligibility criteria:
inclusion criteria: * bmi 18-28 kg/m2 asa physical status 1-2 diagnosed meningeoma and will have selective meningeoma resection surgery the incision will be conducted at the frontal, top or the temperal skull. exclusion criteria: * previous brain surgery severe systemic disease (heart, lung, kidney, or immune system) nerval or mental disorders a history of addiction to opioids allergic to ropivacaine infection at block site or severe systemic infection refuse to attend the trial
influence of probiotics on clinical parameters, the oral microbiome and the immune system during an orthodontic treatment

Conditions: Gingivitis; Orthodontic Appliance Complication

Summary: orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. it its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions. however, studies could show that an increase of certain inflammatory cytokines during orthodontic treatment correlated with a higher risk of root resorption. moreover, it has been shown that orthodontic treatment leads to a dysbiosis of the oral microbiome especially during the first 3 months of the orthodontic treatment. this could be a potential risk factor as the inflammation of periodontitis during an orthodontic treatment could favor root resorption and progressive destruction of the periodontal apparatus. probiotics are already used successfully as an adjuvant therapy in the treatment of periodontitis to improve clinical parameters and to reduce local inflammation. however, there are only a few studies that investigated the influence of probiotics during an orthodontic treatment. therefore, the aim of the study is to investigate if the daily intake of lozenges containing probiotics versus placebo lozenges during the first 3 months of orthodontic treatment with fixed appliances can improve clinical parameters, reduce local inflammation and prevent a dysbiosis of the oral microbiome.


Eligibility criteria:
inclusion criteria: * adolescents from age 12 to 17 with fixed appliances undergoing orthodontic treatment * signed declaration of consent by the patient and the parent or legal guardian for adolescent patients exclusion criteria: * systemic or metabolic disease that are related to gingivitis or (e.g. diabetes) or could possibly influence the oral microbiome * obesity: -adolescents: body mass index \> + 2 standard deviations (sd) over the average value given by the world health organisation (weight and height will be measured) * eating disorder or underweight -adolescents: bmi \> -2 sd under the average value given by the who (weight and height will be measured) * above-average consumption of milk products: \> 3 portions/day = \>1,2 liters of milk or 1200g yoghurt/day (daily dose recommended by the german society for nutrition = 1-3 portions of milk products) * allergy to ingredients of the lozenges * intake of antibiotics or dietary supplementation (probiotics, vitamin c/d) in the last 6 months or during the study * regular use of antibacterial mouth wash * pregnancy * smoking * retraction of the declaration of consent by the patient and the parent or legal guardian for adolescent patients

Keywords: orthodontics; inflammation; microbiome; probiotics
work stress and impact of pruritus on quality of life

Conditions: Psoriasis

Summary: work stress and pruritus: imbalance of effort balance reward in patients with psoriasis.

background. stress increases the likelihood of psoriasis flare-up episodes and itching. few studies have focused on work-related stress on such skin symptoms. objective. to study the association between work-related stress, pruritus and quality of life among workers suffering from psoriasis. methods. investigators will conduct a monocentric non-interventional prospective study. patients suffering from psoriasis will be recruited in both the dermatology inpatient ward and outpatient clinic of brest university hospital . included patients will be workers. work-related stress will be assessed using the effort-reward imbalance (eri) model. the impact of pruritus on quality of life will be assessed with the itchy quality of life (itchyqol) self-administered questionnaire. the collected data will include age, sex, body mass index, ordered medication to treat psoriasis, weekly working hours. the association between eri and itchyqol scores will be studied using a univariate logistic regression.

Eligibility criteria:
inclusion criteria: * major patients * active busy patients with psoriasis presenting for a dermatology consultation or hospitalization at the brest chru * participation agreement exclusion criteria: * presence of another potentially pruritic pathology * no command of the french language * patient under legal protection (guardianship, curatorship, etc.) * refusal to participate

Keywords: psoriasis occupational stress pruritus quality of life
relationship between perioperative sleep disturbance and postoperative delirium

Conditions: Postoperative Delirium

Summary: the investigators are performing this research study to understand the role of sleep disturbance on the incidence of delirium after surgery.

sleep is one of the most important physiological needs. sleep disturbances have detri-mental effects on practically all systems and may thus prolong recovery of patients. studies have documented many similarities between clinical and physiological profiles of patients with delirium and sleep disturbances (ischemia/inflammation, hypoxia, neu-rotransmitter imbalance and tryptophan/melatonin metabolism abnormalities). there is still a lack of strong evidence to support the link between poor sleep and delirium, par-ticularly in hospitalized patients, even though available studies suggest that sleep dis-turbances may be a potential key risk factor for its development, which may have a significant clinical impact. post operative delirium will be diagnosed using the 3d- cam(confusion assessment method) which tests for four features with a series of questions. the features include 1) acute onset and fluctuating course,2) inattention,3) disorganized thinking and 4) altered level of consciousness. diagnosis of delirium is made if features 1 and 2 and either 3 or 4 are present. the demographic data of the patients,type and site of surgery will be noted. preoperative hemoglobin, serum electrolytes and blood urea will be recorded. the intraoperative factors like duration of surgery and anaesthesia,use of intravenous fluids ,blood loss, number blood units transfused and opioid use will be studied at the time of surgery. the time to emergence and extubation following the completion of surgery will be noted. the association of various preoperative,intraoperative and postoperative factors with pod will be determined.

Eligibility criteria:
inclusion criteria: geriatric surgical patients ≥65 years old exclusion criteria: patients in the central nervous system group were excluded from cardiac and neurosurgery, patients in the heart injury group were excluded from cardiac surgery, and patients who did not agree to participate in the study were excluded in all groups.
assessment of serum levels of adenosine deaminase and immunoglobulin e in patients with chronic spontaneous urticaria

Conditions: Chronic Spontaneous Urticaria

Summary: adenosine deaminase activity (ada) has been reported to be elevated in various diseases such as psoriasis, acne and juvenile idiopathic arthritis. there is no previous studies that assessed ada in chronic spontaneous urticaria (csu) .


Eligibility criteria:
inclusion criteria: * adult patients complaining of csu and a group of age and sex-matched healthy controls (blood donors). exclusion criteria: * pregnancy and lactation. * patients with systemic diseases, especially those with autoimmune diseases and infections. * patients with skin diseases. * patients on medications such as antibiotics, nonsteroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, anticonvulsants, penicillin, and combined oral contraceptives.

Keywords: chronic spontaneous urticaria adenosine deaminase immunoglobulin e
establishment of a brain and spinal tumor tissue bank

Conditions: Glioblastoma Multiforme; Glioma; Neuroectodermal Tumors

Summary: the purpose of this study is to establish a brain and spinal tumor tissue/specimen repository to serve as a resource for current and future scientific studies.

glioblastoma multiforme (gbm) is the most common and lethal primary brain and spinal tumor in adults. it is nearly uniformly fatal, with a median survival of approximately one year, despite modern treatment modalities. efforts to understand why some patients live longer or shorter than the average may provide insights into the biology of these neoplasms. for years, researchers have tried to identify independent predictors that could help in treatment planning. with the recent interest in molecular biology and molecular genetics, tumor markers are now being examined as potential predictors. a marker that could predict tumor response to therapy, the likelihood of recurrence, and survival would thus be quite useful.

Eligibility criteria:
inclusion criteria: * patients must have a suspected or confirmed diagnosis of brain and spinal tumor * age greater than 20 * signed consent exclusion criteria: * known hiv infection * any other clinical condition which, in the opinion of the principal investigator, would not allow completion of this study

Keywords: tissue bank glioblastoma multiforme nat2 egfr mgmt brain and spinal tumorgliomas
effects and mechanism of mosapride citrate on diabetic gastroparesis

Conditions: Diabetic Gastroparesis

Summary: the purpose of this study is to evaluate the effects and mechanism of mosapride citrate on diabetic gastroparesi.

to evaluate the effect of mosapride on dpg by 13 c - octylic acid breath test. if c13- octylic acid be absorbed by mucous membrane of small intestine, octylic acid will be oxidated to co2.patients eating food containing c13, and then collect their expired gas at 15, 30,45,60,75,90,105,120,150,180,210,240min, analyse the mass of c13 by mass spectrometer, then can calculate the gastric emptying rate.

Eligibility criteria:
inclusion criteria: 1. 18≤ age ≤ 75 2. patients coincided to, the who diagnostic criteria for diabetes in 1999 (namely have diabetes symptoms, plasma glucose tendency for 11.1 / l, at any time or fasting plasma glucose tendency for 7.0 / l, or oral glucose tolerance test 2 h plasma glucose levels tendency for 11.1 / l） 3. fasting blood-glucose≤7.0mmol/l and 2h postprandial plasma glucose≤10.0mmol/l 4. be diagnosed diabetes more than 5 years, blood sugar steady in one month. 5. have the following symptoms for over 4weeks: early satiety ,postprandial fullness ,nausea, vomting,abdominal distension,belching, inappetence, epigastric pain, constipation. 6. be diagnosed as delayed gastric emptying by c13 breath test. 7. signed informed consent. exclusion criteria: 1. take gastrointestinal drugs within 2 weeks prior to screening. or patients with other digestive disease. 2. all patients will be administrated gastroscope in order to exclude stomach or duodenum disease, pyloric obstruction. it's normal in liver, gallbladder, pancreas,spleen, nephridium by ultrasound examination . 3. serious ketoacidosis. 4. history of abdominal operation. 5. thyroid hypofunction or hyperthyroidism. 6. nervous system disease or autoimmune diseases.
the türkish version of the freezing of gait questionnaire

Conditions: Parkinson Disease; Motor Disorder; Gait Disorders, Neurologic

Summary: the freezing of gait (fog) is one of the disabling symptoms in parkinson's disease. the diagnosis and assessment of the fog may be diffucult, but it is absolutely necessary. the aim of this study was to develop a türkish version of the freezing of gait questionnaire (fog-q) and assess the validity and reliability of this türkish version. the researchers firstly communicated with the developers of the fog-q. the permission for turkish version was received by giladi. then, the fog-q will be adapted into türkish using forward-backward translation by three native türkish-speaking forward translators and one native english-speaking backward translator. the internal reliability of the fog-q türkish version will be assessed using cronbach's alpha, and item analyses will be conducted by examining the effect on cronbach's alpha of excluding each of the six fog-q items individually. the test-retest reliability will be assessed using intraclass correlation coefficient (icc). convergent validity will be evaluated by means of spearman rank correlation coefficient (rs). in this section will be determined the correlation between the fog-q scores and scores of the updrs motor section , berg balance scale, timed up and go test, falls efficacy scale and hoehn and yahr stages.


Eligibility criteria:
inclusion criteria: * a clinical diagnosis of idiopathic pd * able to walk with or without a walking device exclusion criteria: * a diagnosis of other neurological disorders * any other medical conditions * not able to take commands.