Kornimate/medical-research-clean huggingface dataset:
epicardial fat pads ablation during coronary surgery

Conditions: Atrial Fibrillation; Ischemic Heart Disease

Summary: the aim of this prospective randomized study was to assess the efficacy of ablation of the ganglionated plexi localized in the epicardial fat pads for preventing recurrences of atrial tachyarrhythmia in patients with paroxysmal atrial fibrillation undergoing coronary artery bypass grafting.


Eligibility criteria:
inclusion criteria: * history of paroxysmal atrial fibrillation (recurrent episodes for at least 1 years, with 2 documented episodes over the last 6 months) * indication for cardiac surgery (e.g. coronary artery bypass grafting, valve repair/replacement) according to the american college of cardiology/american heart association (acc/aha) guidelines for cardiac surgery exclusion criteria: previous heart surgery or atrial fibrillation ablation procedure emergency coronary artery bypass grafting unstable angina or heart failure persistent atrial fibrillation planned maze procedure or pulmonary vein isolation unwillingness to participate

Keywords: atrial fibrillation ganglionated plexi ischemic heart disease
prospective evaluation of patients with uterine cervical cancer in brazilian health institutions - the evita i study

Conditions: Cervix Cancer

Summary: the primary objective of this study is to describe the socio-demographic, clinical pathological, quality of life and treatment characteristics of patients diagnosed with cc in brazil.

the primary objective of this study is to describe the socio-demographic, clinical pathological, quality of life and treatment characteristics of patients diagnosed with cervix cancer (cc) in brazil. other specific objectives are: * to describe socio-demographic characteristics: age at diagnosis, education, family income, race, occupation, personal health habits - e.g.oral contraceptive use ever/never and duration; smoking never/ever/current/duration , ever drinking), sexual history, insurance coverage (private, public), institution (private, public, philanthropic), obstetric history, comorbidities, performance status, human papillomavirus vaccination or not * to describe the screening for cc: access, type, frequency and results. * to describe clinical pathological characteristics of cc: histology (adeno x squamous x adenosquamous x neuroendocrine x other) , international federation of gynecology and obstetrics (figo) stage, pathological stage, exams for staging, date of diagnosis, site of metastasis. * to describe treatment characteristics of cc: date of surgery, type of surgery; date and duration of radiotherapy, type of radiotherapy; date, type and lines of systemic therapy (chemotherapy, monoclonal antibodies), * to describe treatment safety (grade 3-4 aes, death due to treatment toxicity, discontinuation due to ae). in addition adverse events of special interest will be described (details on safety section). * to describe the outcomes: follow-up exams and date of visits, persistent disease, recurrence, progression times in metastatic disease, complications (e.g. hydronephrosis/nephrostomy/ gi perforations and both gi \& genitourinary fistulae.), death due cc and death from any cause.

Eligibility criteria:
inclusion criteria: * histologic confirmed invasive cervical cancer * diagnosis of figo stages * stage 1b to 2a high risk * 2b-4b or recurrent disease * patients ≥18 years old exclusion criteria: 1. non-invasive uterine carcinoma; 2. pregnancy; 3. synchronous tumor or second primary tumor in the past 5 years (except thyreoid ancer or non-melanoma skin cancer).

Keywords: cervix cancer
khalifa acute effects

Conditions: Totally Ruptured Anterior Cruciate Ligament in the Knee

Summary: the primary hypothesis is that khalifa's therapy has different acute effects in various organ systems i.e. proprioceptive, neuro-muscular, endogenous dopamine system, etc. these effects might indicate the pathway of the therapy.

according to our previous study that evaluated the efficacy of khalifa's therapy the investigators have seen that the therapy has acute effects which resulted in better knee function and later even in better healing of the acl injury. this study should clear exactly which effects and pathways are involved in the therapy from multiple (interdisciplinary) point of views. therefore the investigators will measure parameters that might be associated with this special technique directly before and after the therapy.

Eligibility criteria:
inclusion criteria: * totally ruptured acl - mri verified, 2 weeks old as a maximum * knee function: any functional inhibition (stretching, bending or load) * bmi: 18-25 * athletically active exclusion criteria: * any surgical procedures at the injured knee at any previous time * any acute surgical indication * diabetes mellitus and/or high blood pressure * any permanent drug treatment

Keywords: acl knee ligament cruciate anterior
fertility and temporality in pediatric oncology

Conditions: Fertility Issues; Childhood Cancer; Psychology, Social

Summary: background: when a cancer is diagnosed in a child, the urgency is to take therapeutic actions. children and their families face the reality of cancer and the reality of the treatments that, in addition to be overwhelming, might cause infertility. immediately after the diagnosis, a fertility preservation consultation is proposed to discuss fertility preservation options. in practice, it is often difficult to organize. several years after the end of treatments, a second information consultation is proposed to inform about fertility, evaluate the fertility status and propose a second line of fertility preservation when possible. the literature reflects a lack of knowledge regarding the degree of fertility-related distress among pediatric cancer patients as well as insufficient tools at the disposal of medical doctors and nurses to discuss about reproduction with children and young adolescents. project objective: understand how young cancer patients and their parents felt about sterility risk at the diagnostic time and now as cured adolescents. patients \& methods: 300 patients (15-25 years) from 5 different centers (20 patients per year and per center for 3 years) will be included in this study at the information consultation. they will be surveyed through self-administered questionnaires and semidirected interviews that will 1) retrieve perceptions and emotional being of children during the fertility preservation consultation; 2) assess the decision-making process of parents and family since the fertility preservation consultation through the patient's speech; 3) interview the patients about personal history and experience of cancer and consequences of potential fertility impairment and 4) survey the current experience and projections in the future and evaluate their reaction to the proposition of a second line of fertility preservation. expected results: what points should the doctor / psychologist discuss with pediatric cancer survivors in response to their fertility stress? and how to do it? for better initial and follow-up care to improve their quality of life after cancer.


Eligibility criteria:
inclusion criteria: * age between 15 -25 * having been diagnosed with cancer during childhood or adolescence, * having finished the treatments and being in remission for at least 2 years exclusion criteria: * recurrence of cancer at the time of the study * lack of cognitive autonomy to be able to agree to participate in the study
prevalence of upper limb musculoskeletal abnormalities in type 2 diabetic patients and its relation to hypoglycemic control.

Conditions: Upper Limb Musculoskeletal Abnormalities

Summary: to investigate prevalence of upper limb musculoskeletal disorders and correlations to glycemic control.

). dm is associated with a number of complications including renal disease, peripheral neuropathy, retinopathy, vascular events and musculoskeletal complications. dm is complicated by musculoskeletal problems of upper extremity and particularly the hand, collectively referred as "the diabetic hand." (3) the most common upper limb musculoskeletal disorders associated with dm are adhesive capsulitis, rotator's cuff tendinitis, limited joint mobility (ljm), dupuytren's disease (dd), trigger finger (tf), and carpal tunnel syndrome (cts). upper limb musculoskeletal disorders affect hand functions and activities of daily living (adl). aim of the study: to investigate prevalence of upper limb musculoskeletal disorders and correlations to glycemic control. inclusion criteria: patients will be included to this study(cases) if they are: 1) diabetic patients. 2) age \> 18 years. 3) diagnosed as type 2. exclusion criteria: patients will be excluded if they have rheumatoid arthritis, other rheumatological diseases or previous upper limb surgeries. sample size calculation: by reviewing literature, it is found that the most relevant study (3) to our work found that the prevalence of upper limb musculoskeletal abnormalities in type 2 diabetic patients is .22 and for control group is .05 so, by using piface calculator (version 1.76) to calculate sample size (power = 0.8, alpha error = 0.05 and beta= 0.2) it is found that we need 71 participants for every group. to increase power of the study will enroll 100 participants for every group.

Eligibility criteria:
inclusion criteria: * patients will be included to this study(cases) if they are: 1) diabetic patients. 2) age \> 18 years. 3) diagnosed as type 2. exclusion criteria: - patients will be excluded if they have rheumatoid arthritis, other rheumatological diseases or previous upper limb surgeries.
remote delivery of weight management by phone and social media

Conditions: Obesity

Summary: the purpose of this study is to compare two different weight management delivery methods, social media versus a traditional care model.

obesity is a major public health issue as 68% of the us population is either overweight or obese. weight loss and weight loss maintenance is difficult. traditionally, successful weight loss programs are weekly behaviorally-based clinics which utilize a combination of calorie restriction and physical activity. traditional "face to face" weekly meetings may not be feasible for everyone. an alternative to provide weight loss and weight maintenance created by kumc researchers uses weekly group phone conference calls. while this method produced equal weight loss with fewer burdens to participants when compared to the traditional "face to face" format, weight regain during maintenance was still high. this study will investigate a new delivery method (social media platform "facebook") compared to the group phone conference calls. in the social media platform participants will be able to socialize with other participants in their group by commenting on posts from other participants or posting messages themselves. social media delivered programs have potential to be a more a cost-effective approach to reach a large group of individuals. participants who are eligible and decided to be in this study will take part in study related activities for 6 months.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) of 30 to 45 kg/m\^2 * have access to a computer, smart phone, or tablet * give informed consent to participate exclusion criteria: * unable to participate in moderate intensity pa (i.e., walking) * participation in a weight loss or physical activity program in the previous 6 mos. * greater than 3, 30-min bouts of planned exercise/week * not weight stable (±4.6 kg) for 3 mos. prior to intake * unwilling to be randomized to 1 of the 2 study groups * report being pregnant during the previous 6 mos., currently lactating, or planned pregnancy in the following 6 mos. * serious medical risk such as cancer, recent cardiac event (i.e. heart attack, stroke, angioplasty) as determined by the individual's pcp via the clearance to participate in the investigation * current use of antipsychotics or untreated depression * adherence to specialized diet regimens, i.e., multiple food allergies, vegetarian, macrobiotic * binge eating disorder as assessed by the binge eating scale * living in the same household as another study participant
efficacy of the surgistim3 electrical stimulation device in persons undergoing anterior cruciate ligament repair

Conditions: Anterior Cruciate Ligament

Summary: the purpose of this study is to determine whether a functional electrical stimulation device, the surgistim3, decreases pain, pain medications and/or edema in patients undergoing anterior cruciate ligament repair.


Eligibility criteria:
inclusion criteria: * agree to provide informed consent to be included within this acl study * demonstrate a continued willingness to be compliant with the parameters established under the study; * have no history of drug or alcohol abuse in the last 2 years; * be either a male or female adult between the ages of 18 and 64; * be undergoing a surgical repair of the anterior cruciate ligament (acl) using either a hamstring, patella tendon, achilles tendon, or allograft procedure; and * understand that there is no financial remuneration for participation in the study. exclusion criteria: * pregnant women * insulin dependent diabetic patients * patients with a demand type pacemaker * patients who have a malignant tumor (other than basal cell epithelioma) * patients with a known history of alcohol or drug abuse in the last 2 years * patients who will not agree to provide informed consent to be included within this acl study * patients who demonstrate a continued unwillingness to be compliant with the parameters established under this study. * "poor healers" as identified by the patient's medical history * patients who have a history of sensitivity to surgical tape, electrode adhesives, etc. * patients with a known history of rsd (reflex sympathetic dystrophy) * patients with a history of chronic pain (on opiates or high dosage of nsaids for 3 months or greater) * patients who have previously undergone an acl reconstruction on the same knee * patients with clinically varicose veins (clinically significant or symptomatic) * patients whose history shows an abuse of diuretics or anti-inflammatory medications * patients who will undergo multiple ligament surgery (i.e., acl plus pcl, mcl, and/or lcl)

Keywords: electrical stimulation pain medication edema interferential neuromuscular high voltage pulsed current knee
impact of aerobic training on sleep quality and aerobic fitness in male patients with pulmonary artery hypertension

Conditions: Pulmonary Artery Hypertension

Summary: this study investigated the effect of 12 weeks of aerobic training on sleep quality and aerobic fitness in patients with pulmonary arterial hypertension(pah).

thirty male pah patients were included in the study. they were randomized into two equal groups; training group (a) and control group(b). right ventricular systolic pressure (rvsp) measured using doppler echocardiography , pittsburg sleep quality index (psqi) questionnaire with the wrist worn actigraph used for the assessment of sleep disturbance, and cardiopulmonary exercise testing (cpet) measurements included maximal heart rate and vo2max .all were measured before and after the study period for both groups.the training was a moderate intensity aerobic training on a bicycle ergometer (corresponding to 60% to 70% of the maximal heart rate they reach during peak oxygen uptake in the initial exercise test) for 30 to 45 min/day, 3 sessions/week for 12 weeks (36 sessions).

Eligibility criteria:
inclusion criteria: * patients who were clinically stable and compensated under optimized medical therapy * world health organization (who) classification of functional class ii to iii pah * patients with ejection fraction ≥ 40% * non-smokers * body mass index ≤ 35 kg/m2 exclusion criteria: * any patient with respiratory failure * unstable angina * renal, hepatic or neuromuscular disorders * history of syncopal attacks * uncontrolled systemic hypertension * peripheral vascular disease * serious cardiac dysrhythmias on resting ecg * evidence of severe copd at pulmonary function testing, * any known musculoskeletal or neurological conditions that might interfere with the execution or the assessment of the exercise
hepatitis a virus induced acute acalculous cholecystitis diagnosed postoperatively: case report

Conditions: Acute Acalculous Cholecystitis

Summary: 41-year-old previously healthy patient presented with right upper quadrant abdominal pain. pain started two days prior to presentation when an abdominal ultrasound in a peripheral hospital showed a 10 mm gallbladder stone with normal laboratory tests; however, her pain was resolved on analgesics. now the pain was persistent and associated with vomiting and laboratory tests showed elevated bilirubin. laparoscopic cholecystectomy with intraoperative cholangiography was done that showed inflamed gallbladder but with no stones and normal cholangiography. day one post-operation, while the pain resolved, labs showed elevated liver function tests and hepatitis workup showed acute hav infection attributing her presentation to hav induced aac.

introduction: acute acalculous cholecystitis (aac) is defined as gallbladder inflammation without the presence of stones. contrary, hepatitis a virus (hav) causes acute hepatitis a and can present with different symptoms; however, hav causing and presenting as aac is rare. case presentation: 41-year-old previously healthy patient presented with right upper quadrant abdominal pain. pain started two days prior to presentation when an abdominal ultrasound in a peripheral hospital showed a 10 mm gallbladder stone with normal laboratory tests; however, her pain was resolved on analgesics. now the pain was persistent and associated with vomiting and laboratory tests showed elevated bilirubin. laparoscopic cholecystectomy with intraoperative cholangiography was done that showed inflamed gallbladder but with no stones and normal cholangiography. day one post-operation, while the pain resolved, labs showed elevated liver function tests and hepatitis workup showed acute hav infection attributing her presentation to hav induced aac. discussion: aac is usually caused by stasis of the gallbladder due to different causes; however, hav as the cause of aac has been reported. while cholecystectomy is the mainstay treatment for aac, this might not be the case for hav induced aac. for instance, unless there is necrotic gallbladder or persistence of symptoms, the aac can be managed conservatively in this case. even though our diagnosis was cleared post-operatively, had we know the diagnosis of hav induced aac before, we would still opt for surgery due to the severity and persistence of pain. conclusion: more cases should be reported and more studies should be done to further define the presentation and management of hav induced aac.

Eligibility criteria:
inclusion criteria: * acalculous cholecystitis exclusion criteria: * calculous cholecystitis

Keywords: acute acalculous cholecystitis
feasibility and efficacy of bacopp-21 for patients > 60 years with intermediate or advanced hodgkins lymphoma

Conditions: Hodgkin´s Lymphoma

Summary: this study is designed to test (1) feasibility and efficiancy of new bacopp regimen and (2) toxicity, overall response and fftf.


Eligibility criteria:
inclusion criteria: * hodgkin´s lymphoma (histologically proven) * cs (ps) i and ii with one of the risk factors a-d 1. bulky mediastinal mass (\> 1/3 maximum transverse thorax diameter) 2. extranodal involvement 3. esr \> 50 (a), \> 30 (b-symptoms) 4. 3 or more lymph node areas involved * cs (ps) iii and iv * written informed consent exclusion criteria: * leukocytes \<3000/microl * platelets \<100000/microl * hodgkin´s disease as "composite lymphoma" * activity index (who) \< grade 2

Keywords: hodgkin´s lymphoma eldery patients primary diagnosis
septal shift for the diagnosis of constrictive pericarditis: the impact of inspiratory effort quantification on deep breathing manoeuvres

Conditions: Constrictive Pericarditis

Summary: this study will evaluate the effect of deep breathing manoeuvres on inter ventricular interdependency physiology. by providing further insight in this basic physiology we want to add more comprehensive data in favor or not of constrictive pericarditis diagnostic criteria currently used in cardiovascular magnetic resonance.


Eligibility criteria:
inclusion criteria: * men and women between 18 and 80 years old * normal transthoracic echocardiogram if older than 41 years old * normal standardized history and physical examination * normal blood pressure (\<130/80) * normal 12-lead ecg at rest. exclusion criteria: * no prior pulmonary or cardiac diseases * unexplained symptoms that could be related to a heart or pulmonary problems. * symptoms of or active cardiovascular or pulmonary problems * hepatic or kidney dysfunction * blood cell dyscrasia * cardiovascular risk factor (smoking, hypertension, dyslipidemia, diabetes) * obesity (bmi \> 30) * pregnancy or pregnancy in the last year * cardiac congenital anomalies discovered during the cardiovascular magnetic resonance * current medication with cardiovascular side effects known (diuretics, beta-blockers, calcium channel blockers) * contraindication to cardiovascular magnetic resonance
helicobacter pylori infection in children with chronic idiopathic thrombocytopenic purpura

Conditions: Chronic Idiopathic Thrombocytopenic Purpura; Helicobacter Pylori Infection

Summary: previous studies suggest that chronic idiopathic thrombocytopenic purpura is associated with helicobacter pylori infection. the objective is to study the effect of helicobacter pylori eradication on platelet count.

children with chronic idiopathic thrombocytopenic purpura who have helicobacter pylori infection are enrolled. helicobacter pylori infection is diagnosed by urea breath test. patients who have helicobacter pylori infection will be randomized into 2 groups: control and treatment groups. the treatment group will receive 2 antibiotics and proton-pump inhibitors for 14 days for eradication of infection. repeated urea breath test at week 6-8 after treatment. blood tests for platelet count will be performed every month for 6 months in both groups. platelet count at 6 months in both group will be compared.blood for platelet antibody will be performed at 3 and 6 months. control group will receive treatment for helicobacter pylori at the end of the study.

Eligibility criteria:
inclusion criteria: * children who was diagnosed as chronic itp, defined by platelets below 100,000/ul for more than 6 months without identified causes. * 13c-urea breath test (ubt) was performed for diagnosis of helicobacter pylori infection. exclusion criteria: * patients who had a previous treatment for h. pylori infection. * patients require prednisolone more than 0.5 mg/kg/day

Keywords: chronic idiopathic thrombocytopenic purpura helicobacter pylori infection platelet