Kornimate/medical-research-clean huggingface dataset:
reconstruction plate compared with flexible intramedullary nailing for midshaft clavicular fractures

Conditions: Clavicle Fracture

Summary: the purpose of this study is to compare the clinical and radiographic results of patients with midshaft clavicular fractures treated with plates or intramedullary flexible nails fixation.

midshaft clavicular fractures are classically treated with non-surgical methods, supported by many authors as an effective treatment. however, different researches have shown high rates of nonunion and clavicle malunion related to the nonoperative treatment. currently, indications for surgical treatment are wider and include mainly the following: shortening greater than or equal to 2.0 cm, multiple trauma, open fractures or with imminent exposure and associated neurovascular injury. plate fixation of midshaft clavicular fractures is widely described in the literature, and is considered the gold standard by different authors, associated with a high union rate and a low complication rate. different types of plates have been used, including reconstruction plates, dynamic compression plates (dcp), low-contact dynamic compression plates (lc-dcp), semi-tubular plates, and pre-molded locking plates. possible complications are postoperative infection, hardware loosening or failure, peri-incision paresthesia, neurovascular iatrogenic lesions, nonunion, and hardware related symptoms. elastic stable intramedullary nailing (esin) technique has been used in recent years in the treatment of midshaft clavicular fractures. different studies report excellent functional results and low complication rates. some theoretical advantages in relation to plates are the 3-point flexible nail support, which provides superior biomechanics resistance and uses the relative stability principle, favoring callus formation. when compared to plain steel wires, titanium nails have lower migration risk, due to its greater flexibility and better bone fixation. the purpose of this study is to compare the clinical and radiographic results of patients with midshaft clavicular fractures treated with reconstruction plates or esin.

Eligibility criteria:
inclusion criteria: 1. displaced fractures of the middle third of the clavicle (no contact between the main fragments) 2. age between 16 and 65 year old; 3. terms of consent signed by the patient or guardian. exclusion criteria: 1. fracture of medial or lateral third of the clavicle; 2. cortical contact between the main fracture fragments; 3. age below 16 years old or more than 65 years old; 4. pathological fracture; 5. ipsilateral previous injuries of the shoulder or upper limb; 6. ipsilateral associated fractures of the shoulder or upper limb; 7. neuro-vascular injury associated; 8. open fracture not eligible for primary internal fixation; 9. clinical contraindication for surgery; 10. fracture older than 30 days; 11. patient not cooperative or ineligible for the follow-up; 12. lack of consent to participate.

Keywords: clavicle clavicular fracture midshaft plate esin intramedullary flexible nailing
a randomized, placebo-controlled, double-blinded phase i safety and immunogenicity trial of recombinant envelope protein, hiv-1 sf-2 rgp120 (biocine), combined with mf59 in hiv-1 uninfected adult volunteers

Conditions: HIV Infections

Summary: to determine the safety and immunogenicity of rgp120/hiv-1sf2 combined with mf59 adjuvant emulsion versus mf59 alone in hiv-negative volunteers. one approach to improve the immunogenicity of an hiv-1 subunit protein vaccine is to combine the immunogen with an adjuvant.

one approach to improve the immunogenicity of an hiv-1 subunit protein vaccine is to combine the immunogen with an adjuvant. healthy volunteers receive intramuscular injections of rgp120/hiv-1sf2 with mf59 adjuvant emulsion or mf59 alone at months 0, 1, 6, 9, 10 and 12 (was months 0, 1, 6 and 10, amended 12/19/96).

Eligibility criteria:
inclusion criteria volunteers must have: * normal history and physical exam. * hiv negativity. * absolute cd4 count \>= 400 cells/mm3. * normal urine dipstick with esterase and nitrite. * lower risk sexual behavior. exclusion criteria co-existing condition: subjects with the following symptoms or conditions are excluded: * positive hepatitis b surface antigen. * medical or psychiatric condition (such as recent suicidal ideation or present psychosis) that precludes compliance. * active syphilis. note: subjects with serology documented to be a false positive or due to a remote (\> 6 months) treated infection are eligible. * active tuberculosis. note: subjects with a positive ppd and a normal chest x-ray showing no evidence of tb and not requiring isoniazid therapy are eligible. subjects with the following prior conditions are excluded: * history of immunodeficiency, chronic illness, autoimmune disease, or use of immunosuppressive medications. * history of anaphylaxis or other serious adverse reactions to vaccines. * history of serious allergic reaction to any substance, requiring hospitalization or emergent medical care (e.g., stevens-johnson syndrome, bronchospasm, or hypotension). * prior psychiatric condition (such as history of suicide attempts or past psychosis) that precludes compliance. * history of cancer unless there has been surgical excision that is considered to have achieved cure. prior medication: excluded: * live attenuated vaccines within 60 days prior to study entry. note: medically indicated killed or subunit vaccines (e.g., influenza, pneumococcal) do not exclude if administered at least 2 weeks from hiv immunizations. * experimental agents within 30 days prior to study entry. * prior hiv vaccines. prior treatment: excluded: * blood products or immunoglobulin within the past 6 months. identifiable high-risk behavior for hiv infection, including: * history of injection drug use within past 12 months. * higher risk sexual behavior.

Keywords: vaccines, synthetic hiv-1 adjuvants, immunologic hiv envelope protein gp120 aids vaccines hiv seronegativity hiv preventive vaccine
tele-rehabilitation group program for urinary incontinence in older women

Conditions: Urinary Incontinence; Urinary Stress Incontinence

Summary: the recommended treatment for urinary incontinence (ui) in women is individualized pelvic floor muscle training (pfmt), a costly and resource-intensive approach; one canada is currently unable to meet. a recent non-inferiority randomized controlled trial just confirmed that group-based pfmt is equally effective but less resource-intensive (more cost-effective) than individual pfmt to treat ui in older women (clinicaltrials.gov identifier: nct02039830). in times of covid-19 however, with the quebec, canada's public health authorities preventing gatherings to stop the virus' spread, the potential of in-person group approaches is temporarily limited. it is thus important to develop innovative ways to deliver this first-line treatment remotely, particularly for those confined at home for whom ui can have a detrimental impact on physical health and quality of life. ensuring an online option for group-based pfmt would also allow to increase the accessibility of ui treatment for women living in rural or remote areas in canada, where pelvic floor rehabilitation services are not available or scarce. to this end, this study will assess the feasibility, acceptability and effects of a tele-rehabilitation pfmt group program for ui in older women.


Eligibility criteria:
inclusion criteria: 1. 65 or older, as older women will show a particular genitourinary profile compared with younger women, notably due to menopause. this age cut-off was used in other studies in ui; 2. ambulatory (able to walk, move about safely and autonomously without any mobility device); 3. describe a pattern of stress/mixed ui, confirmed using the questionnaire for incontinence diagnosis (quid); 4. have at least three urinary leakage per week, persisting for 3 months or more; 5. understand french or english instructions; 6. report no important cognitive deficit (determined with a mini-mental state evaluation (mmse) score of 24/30 or more); 7. have an internet access; and 8. able to give informed consent and complete a gynecological examination and fill 7-day bladder diaries and questionnaires. exclusion criteria: 1. present risk factors known to interfere with the effects of pfmt or with the pfm evaluation, including chronic constipation (as defined by the international working committee for chronic constipation), important pelvic organ prolapse (baden-walker score \> stage 2), or any other comorbidities with a potential impact on the treatment (i.e. cognitive impairment, diabetes, active cancer, respiratory or cardiovascular conditions, etc); 2. currently taking medication for ui or medications affecting skeletal muscles; 3. considered obese with a body mass index (bmi) over 35; 4. had an active urinary or vaginal infection in the past 3 months; 5. underwent a change in hormonal replacement therapy in the past 6 months; 6. received pelvic floor physiotherapy treatment or surgery for ui or pelvic organ prolapse in the past year

Keywords: female aging physiotherapy physical therapy pelvic floor rehabilitation telerehabilitation
exercise interventions of eye muscles post strabismus surgery

Conditions: Strabismus; Amblyopia

Summary: it will be hypothesized that: * eye exercises have a positive effect on correction of remaining ocular deviation post strabismus surgery. * eye exercises have a positive effect on improving amplyobia.

this study applied to determine the effect of physiotherapy exercises on correction the remaining ocular deviation which still present following the strabismus surgery and also its effect on amplyobia. different type of physiotherapy exercises was applied to experimental group for 12 weeks beside the medical treatment applied post-surgery while the control group received traditional treatment only. the near and far angles of ocular deviation were measured before and after the treatment for evaluation of strabismus and measuring visual acuity for evaluation of amplyobia.

Eligibility criteria:
inclusion criteria: * patients received strabismus operation * all types of strabismus surgery will be included * they selected from outpatient clinic * patients begin the training program after 2 weeks of operation or more than this * the patient still suffering from amblyopia post strabismus surgery exclusion criteria: * muscular disorders that will impair performance during training. * neurological disorders. * malignant conditions. * psychiatric illness, severe behavior or cognitive disorders. children who can't understand the therapist's instructions and orders.

Keywords: strabismus and amplyobia and physiotherapy eye exercise
prospective exploratory study of fapi pet/ct in prostate cancer with histopathology validation

Conditions: Metastatic Malignant Neoplasm in the Prostate Gland; Prostate Carcinoma; Recurrent Prostate Carcinoma

Summary: this exploratory study investigates how a new imaging technique called fapi pet/ct can determine where and to which degree the fapi tracer (68ga-fapi-46) accumulates in normal and cancer tissues in patients with prostate cancer. because some cancers take up 68ga-fapi-46 it can be seen with pet. fap stands for fibroblast activation protein. fap is produced by cells that surround tumors. the function of fap is not well understood but imaging studies have shown that fap can be detected with fapi pet/ct. imaging fap with fapi pet/ct may in the future provide additional information about various cancers including prostate cancer.

primary objective: i. to define the biodistribution of gallium 68ga-fapi-46 in normal and cancer tissues of patients with prostate cancer. secondary objectives: i. to evaluate whether 68ga-fapi-46 and gallium ga 68-labeled psma-11 (68ga-psma-11) accumulation observed by positron emission tomography (pet) correlates with the amount of fibroblast activation protein (fap) and prostate specific membrane antigen (psma) in excised cancer tissue, respectively. ii. to assess the 68ga-fapi-46 biodistribution correlation with 68ga-psma-11. outline: patients receive 68ga-fapi-46 intravenously (iv) and undergo pet/computed tomography (ct) imaging over 20-50 minutes.

Eligibility criteria:
inclusion criteria: * patients who underwent a 68ga-psma-11 pet/ct scan within 3 months of enrollment * patients who are scheduled to undergo surgical excision or biopsy of a prostate cancer primary, recurrent or metastatic lesion * patients can provide written informed consent * patients are able to remain still for duration of imaging procedure (up to one hour) exclusion criteria: * patients with any new prostate therapy between the psma pet/ct and the fap inhibitor (fapi) pet/ct
reducing catheter-related bloodstream infections in the icu with a chlorhexidine-impregnated sponge (biopatch)

Conditions: Catheter-related Bloodstream Infection

Summary: we proposed to perform a prospective randomized controlled trial to study the effect of the use of a commercially-available chlorhexidine-impregnated sponge (biopatch) as part of central venous catheter care on catheter-related bloodstream infections among patients in two barnes-jewish hospital icus.

at the time of the inception of this study, there were no published randomized controlled trial on the efficacy of the biopatch in reducing bloodstream infections. preliminary data has shown that the biopatch decreases colonization of the catheter exit site and thereby decrease bloodstream infections but this was at that time only theoretical.

Eligibility criteria:
inclusion criteria: * patients who are admitted to the icu with a central venous catheter (i.e. triple lumen catheters, quadruple lumen catheters, percutaneously inserted central catheters, arterial catheters, intraaortic balloon pumps, swan-ganz catheters). exclusion criteria: * patients who are not enrolled into the trial within 7 days of having the catheter being placed and patients who are allergic to chlorhexidine.
proteomics of papillary thyroid carcinoma

Conditions: Papillary Thyroid Carcinoma

Summary: thyroid carcinoma is the common endocrine system malignant neoplasm. at present it has become the malignant neoplasm of fastest growing incidence rate. more than 85% thyroid carcinoma is papillary thyroid carcinoma. cervical lymph node metastasis is common in papillary thyroid carcinoma patients. this study aim to reveal protein expression differences between papillary thyroid carcinoma with cervical lymph node metastasis and without cervical lymph node metastasis.

1. object: patients aged 18-65 years; newly diagnosed papillary thyroid carcinoma with cervical lymph node metastasis and without cervical lymph node metastasis and undergone thyroidectomy according to the china thyroid association guidelines for the management of thyroid nodule and thyroid cancer. 2. clinical information, examination data: information is obtained from medical record abstraction. 3. samples: fresh frozen thyroid tissues from each sample group(normal histology, benign disease, papillary thyroid carcinoma with cervical lymph node metastasis, papillary thyroid carcinoma without cervical lymph node metastasis ).

Eligibility criteria:
inclusion criteria: * newly diagnosed papillary thyroid carcinoma. * undergo thyroidectomy according to the china thyroid association guidelines forthe management of thyroid nodule and thyroid cancer. exclusion criteria: * current substance abuse/dependence. * daily tobacco and alcohol use. * whole neck irradiation or surgery. * prior cancer diagnosis or chemotherapy treatment. * active autoimmune disorder. * uncontrolled allergic condition or asthma. * chronic use of oral steroid medication. * hormone therapy (estrogen, progestin compounds).

Keywords: proteomic cervical lymph node metastasis
emergency management of minor blunt thoracic trauma

Conditions: Thoracic Injuries,

Summary: thoracic traumas are frequent causes of emergency department admissions and the third most common cause of death from trauma. although emergency management of major thoracic traumas that have high mortality and morbidity were discussed and well-understood in detail in the literature, there are limited information regarding diagnosis, emergency management, treatment and follow-up after discharge of patients with minor blunt thoracic traumas. the investigators aimed to investigate demographic data, physical examination findings, and the relationship between lung injury, emergency department final diagnosis, hospitalization, discharge and re-admission rates, effects of prescribed analgesics on pain and re-admissions of patients with a pre-diagnosis of minor blunt thoracic trauma on first admission.


Eligibility criteria:
inclusion criteria: * glasgow coma scale (gcs) of 15 * stable vital signs * admitted within the first 6 hours after injury exclusion criteria: * urgent and urgent triage category

Keywords: minor blunt thoracic trauma physical examination
effects of breathing exercises on fear of covid-19, anxiety, sleep and quality of life during the covid-19 pandemic

Conditions: Healthy Adults

Summary: it has been reported that in the first stages of the pandemic, a significant portion of the general population experienced psychological problems such as anxiety, depression and post-traumatic disorders. these problems persist today. a balanced diet, physical activity participation and relaxation techniques are recommended for preventing such problems. in studies conducted before the pandemic, it is reported that breathing exercises have positive effects on anxiety, sleep and quality of life in both patients and healthy individuals. aim of this study is to investigate the effects of breathing exercises applied via teleconference on fear of covid-19, anxiety, sleep and quality of life in healthy adult population.


Eligibility criteria:
inclusion criteria: * volunteering to participate in the study * having a smart phone that can be used for teleconferencing purposes exclusion criteria: * have had covid-19 * hospital admission for suspected covid-19 in the past week * having acute respiratory tract infection * having any diagnosed chronic respiratory, cardiovascular, metabolic or neurological diseases
reparation of cartilage injuries in the human knee by implantation of fresh human allogenic chondrocytes

Conditions: Cartilage Injuries in the Human Knee

Summary: implantation of fresh human allogenic chondrocytes in human knee cartilage injuries to obtain a repair and prevention of secondary osteoarthritis


Eligibility criteria:
inclusion criteria: * important cartilage injury in the knee exclusion criteria: * important axis deviation * inflammatory joint disorder * severe obesity
effects of tdcs and tus on the perception of pain and functional limitations due to non-specific chronic low back pain

Conditions: Chronic Pain; Chronic Low Back Pain

Summary: the purpose of this study is to assess the effects of tdcs in combination with tus for the treatment of pain and functional limitations in subjects with nsclbp. the investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation.


Eligibility criteria:
inclusion criteria: 1. able to provide informed consent to participate in the study 2. subjects between 18 to 85 years old 3. subjects having non-specific chronic low back pain with existing pain for at least 3 months and having pain on at least half the days in the past 6 months with an average of at least 3 on a 0-10 visual analog scale (vas) scale 4. pain resistant (partial or no response) to common analgesics and medications for chronic pain used as initial pain management such as tylenol, aspirin, ibuprofen, soma, parafon forte dcs, zanaflex, and codeine. 5. must have the ability to feel sensation by von-frey fiber on the forearm exclusion criteria: 1. subject is pregnant 2. contraindications to tdcs in conjunction with tus, i.e. metallic implant in the brain or implanted brain medical devices 3. history of alcohol or drug abuse within the past 6 months as self reported 4. use of carbamazepine within the past 6 months as self reported 5. suffering from severe depression (with a score of \>30 in the beck depression inventory) 6. history of neurological disorders as self reported 7. history of unexplained fainting spells as self reported 8. history of severe head injury resulting in more than a momentary loss of consciousness as self reported 9. history of neurosurgery as self reported 10. unstable pain 11. large placebo responder 12. low adherence during the run-in period 13. low baseline pain

Keywords: transcranial direct current stimulation transcranial ultrasound non-invasive brain stimulation
a gray zone approach of rotational thromboelastometry for predicting postoperative bleeding in cardiac surgical patients

Conditions: Other Functional Disturbances Following Cardiac Surgery; Postoperative Hemorrhage; Coagulation Defect; Bleeding

Summary: rotational thromboelastometry (rotem) is reliable point of care management of coagulation disorder undergoing surgery. recently, there are some reports about prediction of perioperative bleeding using rotem. but, the effectiveness of rotem for predict bleeding and improve outcomes is still debate. in this retrospective study, the investigators will compare immediate postoperative bleeding with rotem parameters using a gray zone approach, and access the reliability of rotem for prediction of bleeding after cardiac surgery.


Eligibility criteria:
inclusion criteria: * cardiac surgical patients using cardiopulmonary bypass exclusion criteria: * known coagulation disorder * using deep hypothermic circulatory arrest * using partial cardiopulmonary bypass
efficacy of pediatric manual therapy in the positional plagiocephaly

Conditions: Plagiocephaly; Plagiocephaly, Nonsynostotic; Plagiocephaly, Positional

Summary: this study evaluates the efficacy of pediatric manual therapy in the treatment of positional plagiocephaly in infants. 40 participants will receive a protocol of pediatric manual therapy and educational physiotherapy in combination, while the other 20 will receive only educational physiotherapy

the manual therapy has shown efficacy in different pathologies in the adult but it is not know its utility in infants and children population, nor in specific pathologies as non synostotic plagiocephaly. in the conservative treatment of plagiocephaly the educational physiotherapy and the helmet therapy have the better level of evidence among other treatments. a protocol of ten sessions of pediatric manual therapy will be applied to infants with positional plagiocephaly in combination with educational physiotherapy. the protocol consists in soft cervical mobilisation, myofascial induction and the application of some pressures to the cranial bones to improve the asymmetry of the head. educational therapy which consists in more "tummy time" stimulation, stimulation to the non preference position of the head and counter positioning. the control group will receive only educational therapy.

Eligibility criteria:
inclusion criteria: * sign of positional plagiocephaly * infants below 6 moths age exclusion criteria: * no neurological disorders * no infectious diseases * no respiratory diseases * no other treatments

Keywords: manual therapy cranial assymmetry cranial deformation physical therapy