Kornimate/medical-research-clean huggingface dataset:
the western ontario rotator cuff index arabic version

Conditions: Surveys and Questionnaires; Rotator Cuff Injuries

Summary: to evaluate, translate, culturally adapt, validate, and investigate the reliability of arabic version of the western ontario rotator cuff index (worc). the null hypothesis of this study will be stated as: arabic language version of the worc doesn't have face, content, or construct validity enough to measure quality of life related to rotator cuff disorders in arabic patients. arabic language version of the worc doesn't have reliability to measure quality of life related to rotator cuff disorders in arabic patients

the worc is an increasingly applied outcome measure for rotator cuff conditions. the worc is a self-assessment scale that was developed to measure the quality of life of patients with rc disorders. it contains 21 items representing 5 subscales: physical symptoms 6 items, sports/recreation 4 items, work 4 items, lifestyle 4 items, and emotions 3 items, which encompass all aspects of heath as defined by the world health organization. it has been translated and validated in several languages, including chinese, dutch, french-canadian, japanese, norwegian, persian, polish, portuguese - brazilian, spanish, swedish and turkish. the current studies point out the increasing need for a questionnaire specifically developed to measure health related quality of life in patients treated conservatively, and respecting the following main characteristics: presenting adequate measurement properties and allowing to make comparisons of health-related quality of life between patients. cross-cultural adaptation allows globalization of information worldwide without the loss of the conceptual meaning. this enables the exchange and comparisons of valid information among different populations worldwide. the western ontario rotator cuff index has not been translated into the arabic language, so it has a limited use in egypt as well as arabic countries. therefore, the aim of this study is to translate, culturally adapt, validate, and investigate the reliability of arabic version of the western ontario rotator cuff index.

Eligibility criteria:
inclusion criteria: * referred with rotator cuff tendinopathy or rotator cuff partial tear by physician. * able to read and write in arabic. * their age will be between 18 to 60 years old * patients with chronic inflammatory diseases will be included exclusion criteria: * patients with impairments in the cervical spine, elbow, or hand affecting the shoulder function * patients that have cognitive alterations * patients that have any systemic disease that may affect patient's outcome.
ni-0801 in allergic contact dermatitis

Conditions: Allergic Contact Dermatitis

Summary: the purpose of the study is to assess the effect of a single dose of ni-0801 on the severity of nickel-induced allergic contact dermatitis.


Eligibility criteria:
inclusion criteria: * aged ≥ 18 and ≤ 70 years * either male or a female lacking childbearing potential * previously documented nickel allergy exclusion criteria: * any medical condition that, in the opinion of the investigator, would interfere with safe completion of the trial or that would prevent subjects from providing informed consent. * known or previous diagnosis of malignancy * known current active tuberculosis or a history of active tb within 12 months of screening * known infection with hiv, hepatitis b or c
splanchnic nerve anesthesia in heart failure

Conditions: Heart Failure

Summary: patients admitted for acute heart failure and undergoing right heart catheterization will be enrolled in this study. subjects will undergo catheterization of the heart to obtain central cardiac pressure and other cardiac hemodynamic parameters. subsequently, the subject will undergo a regional nerve block of the splanchnic nerves. patients will remain in the catheterization lab for the duration of anesthetic block and will be continuously hemodynamically monitored. this study will be a prospective, uncontrolled clinical trial. the study will not be controlled as invasive monitoring of hemodynamics will be performed, allowing clear demonstration of a cause-effect relationship. the goal of the study is to provide proof of concept.


Eligibility criteria:
inclusion criteria: * diagnosis of heart failure (hf) * prior admissions for decompensated hf * symptomatic with dyspnea with clinical, radiographic or echocardiographic signs of fluid overload * on a stable hf drug regimen prior to admission * anticipated hospital stay of at least 2 nights following catheterization procedure exclusion criteria: * ongoing treatment with oral anticoagulation other than aspirin * immunosuppressive medications for solid organ transplant * acute mi (stemi or nstemi) within 7 days * evidence of cardiogenic shock within 48 hours * systolic blood pressure \ 180 mmhg * restrictive or constrictive cardiomyopathy * chronic kidney disease stage 3 or higher due to primary renal pathology * pregnancy
shanghai ovarian cancer and family care project

Conditions: Ovarian Cancer

Summary: ovarian cancer is the most lethal gynaecological malignancy, but its incidence in the general population is low. due to the lack of effective prevention and successful screening approaches, most cases are diagnosed at advanced stages, leading to poor prognosis. in order to address the research requirements pertaining to ovarian cancer, the shanghai ovarian cancer and family care project was established. this initiative offers hospital-based resources for investigating ovarian cancer and high-risk populations. the project comprises an on-going ovarian cancer cohort, a high-risk population cohort, and a healthy population cohort. by leveraging these comprehensive cohorts, the project provides a unique platform for in-depth studies on the detection, prevention, early diagnosis, treatment, and prognosis of ovarian cancer.


Eligibility criteria:
participant meet the criteria for one of the following conditions: * patients attending the oncology department require differential diagnosis of ovarian cancer. * patients with known high-risk factors for ovarian cancer, such as history of ovarian cancer or brca-associated cancer, etc. * patients attending the physical examination center who have normal findings on physical examination and no symptoms. exclusion criteria: * individuals with evidence of another active cancer. * individuals who have prior bilateral oophorectomy. * individuals who are unwilling or unable to sign the informed consent form.
sustained attention abilities in schizophrenia

Conditions: Schizophrenic Psychoses

Summary: schizophrenia is a psychiatric pathology, which concerns around 1% of adult population. it is characterized by clinical symptoms combining positive and negative symptoms and thinking disorganization. schizophrenia is also characterized by cognitive deficits, likely to play an important part in adaptation of these patients in their every-day life, and to affect their clinical symptomatology. among them, there are deficits in sustained attention which are associated with a difficulty for these patients to maintain efficiently their cognitive activity on a source of stimulation or task. this basic attentional process is fundamental for the efficiency of the overall of cognitive processes, and so for all behaviors directed on an aim. the question of whether or not patients with schizophrenia have difficulty sustaining attention is of high relevance, in the sense that it could undermine performance on nearly any task and so provide a compelling causal explanation of many other impairments observed in these patients. yet it has not been conclusively answered in over four decades of research. consequently, the main objective of the protocol is to evaluate sustained attention abilities in schizophrenic patients and to better understand the specific functioning of cognitive and neural mechanisms underlying these abilities (attentional resources and cognitive control mechanisms).


Eligibility criteria:
inclusion criteria: * age between 18 and 60 years (include) * men or women volunteers, hospitalized or not * subject affiliated to an health insurance * subject having signed an informed consent (for patients): * presence of dsm-iv tr criteria for schizophrenia (american psychiatric association, 1994) exclusion criteria * a major somatic disorder or non stabilized * medical history likely to affect cerebral anatomy or to be linked to an abnormality (neonatal distress, neurochirurgical intervention, neurological disorders, stroke attack) * any disorders involved in the use of a psycho-active substance (as defined by the dsm-iv) * sensory disabling impairments, and specifically visual acuity \< 8 * general anaesthesia during the 3 months before the study * pregnancy (declared by the subject) * persons in an emergency situation * persons deprived in any way of their liberty * persons in period of exclusion in an other protocol * use of psychotropic substance during the 3 weeks before the study * use of benzodiazepines
echocardiogram and cardiac performance system (cps) ejection fraction validation study

Conditions: Heart Diseases

Summary: non-significant risk device study to conduct evaluation of the performance of new device for monitoring of cardiac function (based on previous iterations 510(k) 173156)

this validation study will help to establish feasibility of using the cps monitor to screen patients for ejection fraction (ef), co, pasp and wedge pressure compared to a standard echocardiogram. no clinical decisions will be made as a result of the cps device ef value and this measurement will be taken for comparison purposes only.

Eligibility criteria:
inclusion criteria: • patients over 18 scheduled for a standard echocardiogram exclusion criteria: * patients with heart transplant history * patients with a implanted left ventricular assist device (lvad) * patients who have surgical scars, wounds, or bandages at the site of sensor placement * inadequate tte imaging windows in left lateral position * otherwise deemed by the investigator as medically unfit to participate * chest deformities including, for example, pectus excavatum

Keywords: cardiovascular
dialectical behavior therapy for adults with autism spectrum disorders

Conditions: Autism Spectrum Disorders

Summary: dialectical behavior therapy (dbt; linehan, 1993) effectively diminishes emotion dysregulation and self-harm behaviors in a number of disorders. however, to our knowledge, no studies have investigated the efficacy of dbt to treat emotional dysregulation associated with self-harm and suicidal behaviors in adults with asd without intellectual disability. this randomized controlled study trial aims to assess the efficacy of a 5-month dbt intervention in adults with asd without intellectual disability who present with self-harm and/or suicidal behaviors.


Eligibility criteria:
inclusion criteria: * ≥ 18 years old * asd diagnosis according to the dsm-5 * iq ≥ 70 * suicidal ideas, suicidal attempts and/or self-harm behaviors 6 months prior to the inclusion * able to understand and consent to the research aims * membership in a health insurance fund exclusion criteria: * complete hospitalization * ongoing cbt or dbt * past dbt * schizophrenia disorders * under guardianship
a comparison between conventional surgery and piezosurgery

Conditions: Third Molars Extraction

Summary: evaluation of the effect of conventional and piezo-surgery on the secretion of heat shock protein (hsp70) and on the vial bone cells at the peripheral bone cut sides after the removal of impacted mandibular third molars on both sides of the jaw.

the study is about measuring the amount of hsp70 using elisa kit for detecting hsp70 and mason trichrome for histological findings in which the study samples are patients who have bilateral impacted mandibular third molar to be extracted with bone removal. first we collect bone sample for mason trichrome with either method then we collect the second samples after removing most of the bones cover the impacted third molar for checking hsp70 levels. then the bone samples are treated using a special protocol to eliminate the protein from bone samples for the elisa analysis. the other bone samples are going to be studied under the microscope.

Eligibility criteria:
inclusion criteria: * bilateral identical impacted third molar that need at least 3 mm of bone removal exclusion criteria: * pregnancy * smokers * infectious diseases * infections around third molars (i.e. pericoronitis). * alcoholic patients
safety study of sorafenib with androgen deprivation and radiotherapy to treat prostate cancer

Conditions: Prostate Cancer

Summary: the purpose of this study is to evaluate the safety of a new drug- sorafenib, which is to be administered at the same time as standard treatment, which includes hormonal therapy and external beam radiotherapy.

leuprolide acetate (a luteinizing hormone releasing hormone (lhrh) agonist) and bicalutamide (an anti-androgen) are hormonal agents which are commonly used to reduce testosterone blood level for prostate cancer treatment. intensity modulated external beam radiotherapy is a standard treatment for localized prostate cancer. previous studies have shown that combining hormonal therapy and radiation is more effective than radiation alone. unfortunately, significant percentages (50-75%) of patients still relapse. sorafenib reduces the growth of cancer cells and has proven effective in the treatment of solid tumors including kidney and liver cancer. this drug is approved by the fda for treatment kidney and liver cancer. the study investigators believe that adding sorafenib to standard treatment, comprising hormonal therapy and radiation, might be more effective then standard hormonal therapy.

Eligibility criteria:
inclusion criteria: * patients must have histologically confirmed intermediate or high risk prostate adenocarcinoma. intermediate risk disease comprises t2b/c tumors, gleason 7 histology, or psa 10-20. high risk tumors comprise t3-4, gleason 8 or higher histology, or psa greater than 20. * age \> 18 years. * life expectancy of greater than 5 years. * patients must have normal organ and marrow function. * no pelvic lymph node metastases based on pelvic ct scan or mri. * no bone metastasis. a whole body bone scan is required to rule out metastatic disease. exclusion criteria: * any previous, radiotherapy, or chemotherapy, or more than 4 weeks of androgen deprivation hormonal therapy for the treatment of prostate adenocarcinoma. * patients may not be receiving any other investigational agents. * history of allergic reactions attributed to compounds of similar chemical or biologic composition to sorafenib or other agents used in this study. * known human immunodeficiency virus (hiv) infection or chronic hepatitis b or c. * patients receiving anti-coagulation treatment with an agent such as warfarin or heparin will not be allowed to participate.

Keywords: prostate cancer combined androgen blockade radiotherapy sorafenib
transdiagnostic rebt prevention program for adolescents

Conditions: Social Anxiety; Major Depression Mild; Panic Disorder; Specific Phobia; Generalized Anxiety Disorder

Summary: anxiety and depressive disorders are common in adolescents, however they are often unrecognized. rational emotive behavioral therapy (rebt), a form of cognitive behavioral therapy (cbt) is efficient for children and adolescents. school settings are appropriate environments to deliver such interventions for vulnerable youths. given youth's access and predilection to use technology, a video-based prevention program was developed. the present study aims to investigate the efficacy of a transdiagnostic rebt prevention program for internalizing symptoms in adolescents, implemented in a school setting. classes from different romanian public schools will be randomized in either intervention or wait list group.

the prevention program will be group-based, delivered in 6 sessions, over 3 weeks. each of the six modules aimed a different component: psychoeducation, relaxation, relationship between cognitive distortions/irrational beliefs and emotions, cognitive restructuring, exposure/ behavioral activation and problem solving, maintenance of gainings. despite specific activities, for each session a video cartoon on that subject will be viewed and discussed. homework would be given at every session. rebt prevention programs delivered in school settings represent ecological modalities to target vulnerable groups. technology components added to traditional programs may lead to greater motivation and satisfaction with treatment. adolescents will complete assessments at four time-points: t1 (baseline), t2 (post-intervention), t3 (3 months follow-up) and t4 (12 months follow-up).

Eligibility criteria:
inclusion criteria: 1. preadolescents and adolescents will have ages between 12 and 17 years old; 2. are attending middle school or high-school; 3. adolescents have sufficient understanding of the romanian language in order to complete assessments at all time points and to participate in the prevention program; 4. their parents have sufficient understanding of the romanian language in order to sign the informed consent; 5. parents will sign the informed consent and adolescents will provide informed assent. exclusion criteria: 1. age below 14 or above 17 years; 2. no signed informed consent from parents; 3. adolescents will score high on suicidal ideation according to (1 item on the depression subscale from beck youth inventories); 4. not romanian-speaking in order to understand the content of the prevention program and to complete the assessments.

Keywords: anxiety symptoms depression symptoms internalizing symptoms
cimt and tavns for hemiplegia in infants

Conditions: Infant Development; Hemiplegia; Constraint Induced Movement Therapy

Summary: newborns who are born premature or suffer brain injury at birth are at risk for motor problems that may cause weakness in reaching and grasping on one side of the body. in older children, therapists may use a hand mitt and restraint for the stronger arm, to encourage use of the weaker side, called constraint-induced movement therapy (cimt). even with the high intensity therapy of cimt, it typically takes between 40-120 hours total treatment time for most children to improve their motor skills. a non-invasive form of nerve stimulation, transcutaneous auricular vagus nerve stimulation (tavns), stimulates a nerve by the ear that enhances learning motor skills. the purpose of this study is to evaluate the safety and effectiveness of tavns to improve motor skills when paired with cimt in infants with one-sided weakness at 6-18months of age.

recent pioneering studies have used neuromodulation combined with intensive motor therapies in adults after stroke. few studies have investigated combining neuromodulation and evidence-based pediatric intensive therapies such as cimt, and then only in older children with cp to enhance neuroplasticity and improve functional outcomes. the investigators are the first to use non-invasive transcutaneous auricular vagus nerve stimulation (tavns) paired with a motor task of bottle-feeding in infants with feeding failure. tavns paired with motor feeding activity was safe and over 50% infants attained full oral feeds who were slated to receive a gastrostomy tube (g-tube). with the unique collaboration of experts in brain stimulation, pediatric translational clinical science and pediatric occupational therapy in this pilot project, the investigators propose to expand the paradigm of pairing neuromodulation with motor training in at-risk infants by exploring the safety, feasibility, and effectiveness of delivering tavns concurrently with cimt. the hypothesis is that combining tavns with intensive cimt may boost neuroplasticity, allowing for delivery of infant therapy at a minimally effective dosage while improving infant outcomes. the investigators aim to determine the feasibility and safety of tavns in at-risk infants 6-18mo undergoing cimt therapy in open label pilot trial and assess both infant tolerability and the therapist's ability to deliver high-quality cimt along with tavns.

Eligibility criteria:
inclusion criteria: must have all of the following: * 6-18 month-old infants with hemiplegia/motor asymmetry * must be able to participate in high intensity cimt * gross motor function classification system (gmfcs) level i-iv exclusion criteria: must have none of the following: * gmfcs level v * severe motor impairment/quadriplegic involvement * uncorrected blindness or deafness * cardiomyopathy

Keywords: transcutaneous auricular vagus nerve stimulation constraint induced movement therapy infant hemiplegia
the impact of creative interventions on symptoms of postnatal depression

Conditions: Depression, Postpartum

Summary: post-natal depression (pnd) is anticipated to affect 12.9% of new mothers with at least 75,000 cases per year in the uk alone. however, despite this, there is currently a worrying lack of support for new mothers, with data suggesting that 64% of healthcare trusts in the uk do not have a strategy for treating postnatal depression, and flaws in the current pharmacological and psychological treatment models. consequently, research into promising psychosocial interventions such as music is critical to developing new paradigms for treating postnatal depression. this project is an ambitious programme of research that investigates the effects of music on postnatal depression through two phases: a questionnaire study and an intervention study. this record is for the intervention study. the questionnaire study has a separate record. we are accepting host hospital sites for both.

the study tests the effectiveness of singing interventions led by the royal college of music at chelsea and westminster hospital as a psychosocial tool to reduce the occurrence and effects of postnatal depression. it triangulates psychological, physiological, and biological data in a randomised control design to provide a comprehensive insight into the intervention's effects in comparison to a more common psychosocial intervention for new mothers (play groups) and a control group of no psychosocial interventions. the study aims to recruit 50-80 women into each of the three interventions (150-240 total). the study will used a mixed-method methodology comprising validated psychological scales, in-depth qualitative interviews and observations and biomarker analysis. if results are promising, there are plans in place to scale the singing intervention to more hospitals and community settings. phase b will be open to nhs sites within the region of chelsea and westminster hospital london from which women could travel to the sessions to take part.

Eligibility criteria:
inclusion criteria: * women who have a child up to 9 months old * symptoms suggestive of pnd at a minimum score of 10 on the epds exclusion criteria: * outside the limits of the number of weeks pregnant/post birth * living outside england * refusal to participants

Keywords: postnatal depression mental wellbeing baby blues mothers music alternative therapies