Kornimate/medical-research-clean huggingface dataset:
to compare the effect of different nutritional pathways on improving nutritional status of esophageal cancer patients undergoing chemoradiotherapy

Conditions: Esophageal Squamous Cell Carcinoma; Chemoradiotherapy; Enteral Nutrition

Summary: this study prospectively recruited esophageal squamous-cell carcinoma patients who received nasogastric tube (ng), gastrostomy feeding and oral intake to compare the changes in nutritional status and quality of life during chemoradiation therapy (crt).


Eligibility criteria:
inclusion criteria: * pathologically or cytologically proven esophageal squamous cell carcinoma * karnofsky performance score(kps) ≧70 * concurrent chemoradiotherapy * hemoglobin≥90.0g/dl,white blood cell count（wbc）≥ 4000 cells/mm³,platelet count≥100,000 cells/mm³ * aspartate aminotransferase (ast) and alanine aminotransferase (alt) \< 2.5 times upper limit of normal,bilirubin normal * creatinine normal or creatinine clearance ≥ 60 ml/min * patients have good compliance to treatment and follow-up of acceptance * the functions of the heart, kidney, liver were basically normal, with no chemotherapy and radiotherapy contraindications exclusion criteria: * patients with severely bowel function impaired or can not tolerate enteral nutrition * patients with serious gastrointestinal obstruction, be unable to take food by mouth and can not / do not want to a feeding tube inserted * patients who have severe vomiting, gastrointestinal bleeding, intestinal obstruction * patients who have distant metastasis * the primary tumor or lymph node already received surgical treatment efuse or incapable to sign the informed consent form of participating this trial
pulmonary rehabilitation and quality of life in children with chronic lung diseases: a multidisciplinary approach

Conditions: Chronic Lung Disease; Quality of Life; Respiratory Function Impaired

Summary: chronic lung diseases (clds) such as asthma, cystic fibrosis, and bronchopulmonary dysplasia significantly impact pediatric patients' respiratory function and overall well-being. pulmonary rehabilitation (pr) has been shown to improve lung function, exercise tolerance, and quality of life in affected individuals. however, limited research has been conducted on pr implementation in egypt.

pulmonary rehabilitation significantly enhances respiratory function, exercise capacity, and quality of life in pediatric patients with clds while reducing healthcare utilization. these findings highlight the necessity of integrating structured pr programs into pediatric respiratory care in egypt.

Eligibility criteria:
inclusion criteria: * diagnosed cases of clds, stable clinical condition, and ability to participate in rehabilitation. exclusion criteria: * severe comorbidities, recent respiratory infections, or contraindications to physical activity.
aortic valve diseases risk factor assessment and prognosis model construction

Conditions: Aortic Valve Disease

Summary: this study is a multicenter cohort study including patients diagnosed with aortic valve disease during hospitalization, including aortic insufficiency and aortic valve stenosis. the primary outcome of the study was all-cause death, and the secondary outcome was cardiovascular events. through follow-up observation, the prognostic risk factors of patients with aortic disease were evaluated, and a prognostic model was constructed to guide clinical decision-making.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * diagnosed as aortic valve disease exclusion criteria: * aortic valve replacement at baseline

Keywords: aortic stenosis aortic valve insufficiency risk factor prediction model
reachallenge trial: acetylcholine rechallenge after pretreatment with vasoactive drugs

Conditions: Angina Pectoris, Variant; Angina Pectoris; Spasm-Induced; Angina Pectoris With Normal Coronary Arteriogram

Summary: the goal of this clinical trial is to assess the feasibility and clinical value of acetylcholine (ach) rechallenge after intracoronary verapamil +- nitroglycerine in a patient cohort with angina and non-obstructive coronary arteries (anoca). the main questions it aims to answer are: * to determine the efficacy of these drugs in treating ach-induced coronary artery spasm * to determine the efficacy of these drugs in preventing ach-induced coronary artery spasm the ach rechallenge will take place during the index coronary function tests in patients with proven ach-induced vasospastic angina. the study is considered a feasibility study, no control arm is included.


Eligibility criteria:
inclusion criteria: * clinically indicated coronary angiogram in the setting of angina with non-obstructive coronary artery disease (anoca) * non-obstructive coronary artery disease is defined as the absence of coronary artery stenosis ≥ 50%, or if ≥ 50% with non-ischemic resting (rfr \> 0.89) and hyperemic indices (ffr \> 0.80). * ach provoked epicardial and/or microvascular spasm * left ventricular ejection fraction (lvef) \> 50% * renal function with egfr ≥ 40 ml/min exclusion criteria: * obstructive coronary artery disease (both chronic and acute coronary coronary syndromes) * any cardiomyopathy (including takotsubo stress cardiomyopathy) or severe valvular disease * lvef \< 50% * long qt syndrome (lqts) - genetic or acquired * ventricular paced rhythm * renal failure with egfr \< 40 ml/min * thyroid stimulating hormone (tsh) \< lower limit of normal (lln). a subject taking thyroid replacement therapy may be enrolled with tsh level below lln if, in the opinion of the investigator, the subject is in a clinically euthyroid state. * known hypersensitivity or contra-indication for either acetylcholine, verapamil, nicorandil or nitroglycerine. * pregnant female subjects. female subjects of child-bearing potential should be on adequate contraceptive measures or are to be screened with a urine pregnancy test.

Keywords: vasospastic angina angina with non-obstructive coronary arteries (anoca) acetylcholine
exploring the benefit of neuromodulation in treating chemo-induced peripheral neuropathy using peripheral neuropathy markers (meissner's corpuscles and epidermal nerve fiber density) and sensory testing (quantitative sensory and gait testing): a single center feasibility study

Conditions: Neuropathy;Peripheral

Summary: to learn if a process called neuromodulation can help to improve pain due to cip

inclusion criteria: * ability to understand and the willingness to sign a written informed consent document * patients diagnosed with cipn lower extremity due to either vinca alkaloids, taxanes, bortezomib, thalidomide, platinum-based compounds * patients seen at pain management center at md anderson cancer center * patient ages greater or equal to 18 years but less than or equal to 85 years exclusion criteria: * patients with cognitive dysfunction * patient with recent history (\<6 months) of drug or alcohol abuse * patients with open skin lesion or undergoing antibiotic therapy for local for systemic infection * patients with painful diabetic peripheral neuropathy or preexisting peripheral neuropathy

Eligibility criteria:
inclusion criteria: * ability to understand and the willingness to sign a written informed consent document * patients diagnosed with cipn lower extremity due to either vinca alkaloids, taxanes, bortezomib, thalidomide, platinum-based compounds * patients seen at pain management center at md anderson cancer center * patient ages greater or equal to 18 years but less than or equal to 85 years exclusion criteria * patients with cognitive dysfunction * patient with recent history (\<6 months) of drug or alcohol abuse * patients with open skin lesion or undergoing antibiotic therapy for local for systemic infection * patients with painful diabetic peripheral neuropathy or preexisting peripheral neuropathy
superficial partial-thickness burn study

Conditions: Superficial Partial Thickness Burn

Summary: this study is an investigator initiated, single site, university of pittsburgh, prospective, parallel group, randomized controlled trial comparing synepure wound cleanser and catasyn advanced technology hydrogel (intervention group) to the current gold standard treatment silvadene (control group). both groups will receive the same care other than the treating agent. subjects will be recruited form the upmc mercy burn center adult patient pool who have sustained superficial partial-thickness burn wounds that comprise less than or equal to 10% of total body surface area (tbsa)

current effective dressings for burn wounds contain silver (nanoparticulate or ionic), hypochlorite, hydrogen peroxide, sulfa agents, chlorhexidine, iodine or other dilute antiseptics meant to provide some measure of antimicrobial protection. however, all of these materials have some proven limitations in facilitating wound healing and also have notable local and systemic adverse effects. none of the current clinical treatments enhance healing and/or reduce scar formation. the purpose of this study is to test the safety and effectiveness of synepure™ wound cleanser when used in combination with catasyn™ advanced technology hydrogel for the treatment of superficial partial-thickness burn wounds.

Eligibility criteria:
inclusion criteria: * ability to provide informed consent * 18 years of age or older, male and female * patients who have sustained superficial, partial-thickness burn wounds ≤ to 10% of total body surface area (tbsa) * patients otherwise in good general physical and mental health, as per the investigator's clinical judgment exclusion criteria: * inability to provide informed consent * deep partial-thickness burns and full-thickness burns * radiation, chemical, or electrical burn injury * patients with burns primarily located to the face, genitals, or span across joints * patients whose burn injury was ≥ to 48 hours prior to entry into the upmc mercy burn center clinic. * patients with uncontrolled cerebrovascular disease, cardiovascular disease, endocrine disease, hepatic disease, or renal disease; or other severe conditions for whom, in the physician investigators' discretion, would render study participation unsafe * patients with documented or self-reported shellfish allergies * current pregnancy * patients with concurrent burn related injuries or inhalation injury that would put the patient at increased risk, per physician discretion * any condition to which in the investigator's discretion would render study enrollment a safety concern for the patient
trans cranial direct current stimulation along with craniosacral therapy on sleep disturbances in patients with chronic low back pain

Conditions: Sleep Disturbance; Chronic Low-back Pain

Summary: sleep problems in patients with clbp are a very common complication and is the most neglected part of the management. though previous literature suggested that sleep problems need to be managed in patients with clbp, no physical therapy or manual therapy techniques has been checked for their efficacy to manage the same. therefore, there is a need to check the efficacy of various physical therapy and manual therapy techniques so that sleep problems associated with clbp can be managed effectively by physical means. the main purpose of the study is to check the efficacy of tdcs and cst to improve sleep, pain and quality of life in patients with clbp.


Eligibility criteria:
inclusion criteria: 1. people with chronic low back pain (more than 3 months) 2. both males and females. 3. 18-50 years 4. able to follow verbal commands. exclusion criteria: 1. diagnosed with primary sleep disorders 2. pregnancy 3. taking any medication for a psychological disorder 4. acute or subacute lbp 5. diagnosed with any other systemic disorder. 6. spinal tumour. 7. radicular pain and nerve root compression. 8. severe spinal stenosis, spondylolisthesis, fibromyalgia. 9. unstable angina and other cardiovascular disorders. 10. malignancy. 11. history of other systemic and inflammatory disease.
new biomarkers in axial sypondyloarthropathy; sii and siri

Conditions: Axial Spondyloarthritis

Summary: investigators aimed to evaluate the relationship between systemic immune inflammation index (sii) and systemic inflammation response index (siri) and disease activity in patients with axial spondyloarthropathy (spa).

the clinical characteristics and laboratory data of the patients and healthy controls participating in our study were obtained through the hospital system. then, the new biomarkers siri and sii values were calculated. siri= neutrophil count\*monocyte count/lymphocyte count and sii= neutrophil count\*platelet count/lymphocyte count. then, siri and sii values were compared between groups. the relationship between disease activity and siri and sii values in the patient group was examined.

Eligibility criteria:
inclusion criteria: * spa patients diagnosed according to the 2009 assessment of spondyloarthritis international society classification criteria * 51 healthy controls working in our hospital, exclusion criteria: infections, coronary artery disease, kidney and liver dysfunction, cancer diagnosis, surgery in the last three months, diabetes mellitus diagnosis, hypertension and pregnant women

Keywords: axial spondyloarthritis systemic immune inflammation index systemic inflammation response index
steno diabetes dialogue cards teaching on group education on blood sugar control in adolescents with type 1 diabetes

Conditions: Type 1 Diabetes; HbA1c; Self-management

Summary: the type 1 diabetes is the autoimmunity system produces the antibody which starts to attack the b lymphocytes while the autoimmunity is also been attacked. when the autoimmunity system has been destoyed, the insulin couldn't be secreted normally. thus, the hyperglycaemia is caused. then, the patients need to rely on the insulin injection throughout the lifetime. the main symptoms are the three mores （eat more, drink more and urinate more）, weight loss, urine sugar, lethargy, ketone bodies and ect. the most serious complications of the diabetes type 1 is the diabetic ketoacidosis, dka. it is caused by the severe infection or poor glycemic control. if the dka happened, the patients need to be rescued in the icu. is because it sometimes endager life. the diabetes type 1 patients rely on the insulin injection throughout the lifetime and a good habbit of diet, boold sugar controlling and exercise. the dka happens when the boold sugar is not well controlled.


Eligibility criteria:
inclusion criteria: * 10-18years ord type 1 dm. * able to read and write chinese. exclusion criteria: * communication and cognitive impairments.

Keywords: type 1 diabetes mellitus steno balance card group health education blood sugar control self-management
maternal thyroid function in early pregnancy and their relationship with gestational diabetes mellitus

Conditions: Pregnancy; Thyroid Function Tests; Gestational Diabetes Mellitus

Summary: this study was conducted to analyze the role of tsh level and tpoab status in early pregnancy and use this information in assessment of the risk of gestational diabetes mellitus at different weeks of gestation when the ft4 level is normal.

a total of 7,729 women with singleton pregnancies who were receiving antenatal care at shanghai first maternity and infant hospital, tongji university school of medicine between december 2012 and march 2014 were included in the study. all these women underwent screening for thyroid function (tsh,ft4 and tpoab) at the first antenatal visit and a 75 g oral glucose tolerance test at 24-28 weeks of gestation. the correlation between a combination of tsh level and tpoab status and the risk of gestational diabetes mellitus was analyzed.

Eligibility criteria:
criteria: inclusion criteria: 1. ≤19+6 weeks of gestation at the first antenatal visit; 2. singleton pregnancy; 3. ft4 level is within the normal range; 4. tsh level is normal or beyond the normal range. exclusion criteria: 1. age \ 40 years; 2. thyroid disease history before pregnancy, e.g. hyperthyroidism, clinical hypothyroidism and malignant tumors of the thyroid, regardless of medication treatment is needed or not; 3. twin or multiple gestations; 4. diagnosed with diabetes mellitus before pregnancy, or fasting blood-glucose level ≥ 7.0 mmol/l or hba1c≥6.5% at the first antenatal visit; 5. diseases causing abnormal glycometabolism or severe co-morbidities or diseases causing abnormal glycometabolism.
using the transconjuctival approach alone versus using it together with lateral canthotomy in orbital fractures

Conditions: Orbital Fractures

Summary: all cases will undergo surgery under general anesthesia. evaluation of patients with suspected orbital fracture should involve radiologic examination, motility test, diplopia field test and exophthalmometry. plain x-ray films, although rarely used, with the caldwell and waters view may be done as a screening evaluation for possible fractures and foreign bodies. an orbital computed tomography, the gold standard in trauma, ct with contiguous thin axial and coronal sections should be ordered to confirm the diagnosis and plan for treatment postoperative care: proper postoperative instructions will be given the patient, in addition to the postoperative medications including antibiotics, corticosteroids and analgesics.

this study will be carried out on patients attending the outpatient clinic in oral and maxillofacial surgery department, faculty of dentistry, cairo university. 10. eligibility criteria: * inclusion criteria: * age group: from 15 to 60 years old. * patients with pure blow-out fractures. * exclusion criteria: * patients suffering from dermatological diseases, 11. interventions: 1. pre-operative phase: patients will be subjected to: 1. case history including personal data, medical, surgical and family history. 2. clinical examination. 3. preoperative anesthesia assessment for fitness for general anesthesia. 4. treatment planning. 2. operative phase: all cases will undergo surgery under general anesthesia. the inferior wall can be easily accessed through transcutaneous or transconjunctival approach (with or without lateral canthotomy). the latter avoids a visible scar and is less likely to result in eyelid retraction. the medial wall can be accessed through transcaruncular approach. careful exploration under the periosteum allows easy visualization of the fracture boundaries as well as correction of the herniated tissue. then various implants can be used to support the orbital soft tissue and prevent recurrent herniation. porous polyethylene sheets (medpor) are one of most commonly used implant materials. other autogenous (cranial, rib or iliac bone graft) or alloplastic (gelatin film, silicone sheet, teflon, supramid, titanium mesh or bioresorbable copolymer plates) materials are also available. periocular fractures are often managed first by the ophthalmologist. with good clinical examination and radiographic imaging, an informed decision can be made whether surgical intervention is required. 3. postoperative care: proper postoperative instructions will be given the patient, in addition to the postoperative medications including antibiotics, corticosteroids and analgesics.

Eligibility criteria:
* inclusion criteria: * age group: from 15 to 60 years old. * patients with blow-out fractures. * exclusion criteria: * patients suffering from dermatological diseases,

Keywords: trans-conjunctival approach
comparison of blood loss in laparoscopic vs open pancreaticoduodenectomy in patients with periampullary carcinoma

Conditions: Periampullary Carcinoma

Summary: the study is designed to compare the blood loss between laparoscopic vs open pancreaticoduodenectomy in a randomized clinical trial

the study will assess the difference in the amount of blood loss in lap vs open wpd. the amount of blood loss will be calculated on the basis of a formula which takes pre operative and post operative hematocrit, pcv and blood volume into consideration.

Eligibility criteria:
inclusion criteria: 1. patients of both the sex aged between \>18 years. 2. patients with a diagnosis of resectable periampullary carcinoma on imaging. 3. patients with asa grade 1 or 2 exclusion criteria: * 1) patients found to have unresectable disease on radiological investigation. 2) patients with asa grade 3 or above
an observational study of peginterferon alfa-2a (pegasys®) in patients with hbeag positive or hbeag negative chronic hepatitis b

Conditions: Hepatitis B, Chronic

Summary: this prospective, multicenter, observational study will evaluate on-treatment predictors of response in patients with hbeag positive or hbeag negative chronic hepatitis b receiving treatment with peginterferon alfa-2a (pegasys®) in accordance with local labeling and the summary of product characteristics. data will be collected from patients for the duration of their treatment and for up to 24 weeks thereafter.


Eligibility criteria:
inclusion criteria: * adult patients ≥ 18 years of age. * hepatitis b envelope antigen (hbeag) positive or hbeag negative hepatitis b with or without cirrhosis. * elevated alanine aminotransferase (alt) \> upper limit of normal (uln) but ≤ 10 x uln according to local label. exclusion criteria: * contraindications to peginterferon alfa-2a (pegasys®) as detailed in the label. * co-infection with hepatitis a, hepatitis c, or human immunodeficiency virus (hiv). * concomitant treatment with telbivudine. * pregnant or lactating women.
slap repair vs. biceps tenodesis in patients under 30: a randomized clinical trial

Conditions: SLAP Tear

Summary: one of the common complaints after slap repair is pain and stiffness. however, the more recently-described biceps tenodesis for slap tears improves upon this by addressing the long head of biceps which is thought to be the pain sources. however, only one small prior rct has evaluated this, finding minimal difference. both procedures are currently considered standard of care, and are decided upon based on patient and surgeon preference. this will be a single-center randomized controlled trial. the study is comparing slap repair and biceps tenodesis in patients under 30 undergoing surgery for slap tears. the purpose of the proposed study is to evaluate the effect of slap repair versus biceps tenodesis in the management of slap tears in patients under 30 years old.

superior-labrum anterior to posterior (slap) tears were first described by andrews et al. in 1985, and have been reported to be present in up to 26% of shoulder arthroscopies. while the exact cause of slap tears is unknown, they are often related to traumatic events and sports activity, particularly overhead sports such as baseball. type ii slap tears, which are characterized by superior labral fraying with a detached biceps anchor, are the most common subtype, based on the classification by snyder et al. treatment options include slap repair, biceps tenodesis, biceps tenotomy, and debridement. one of the common complaints after slap repair is pain and stiffness. however, the more recently-described biceps tenodesis for slap tears improves upon this by addressing the long head of biceps which is thought to be the pain sources. however, only one small prior rct has evaluated this, finding minimal difference. both procedures are currently considered standard of care, and are decided upon based on patient and surgeon preference. this will be a single-center randomized controlled trial. the study is comparing slap repair and biceps tenodesis in patients under 30 undergoing surgery for slap tears. the purpose of the proposed study is to evaluate the effect of slap repair versus biceps tenodesis in the management of slap tears in patients under 30 years old.

Eligibility criteria:
inclusion criteria: * primary indication is for slap tear * age 18-30 * willing and able to provide consent exclusion criteria: * associated rotator cuff tear requiring arthroscopic repair * pregnant patient * previous shoulder surgery * age \> 30, or \< 18

Keywords: slap repair biceps tenodesis