Kornimate/medical-research-clean huggingface dataset:
ablation of renal masses outcomes registry (armor): ablation procedure and quality of life assessment

Conditions: Renal Cancer

Summary: the purpose of this study is to better understand how effective ablation is for destroying tumor cells in the kidney and whether quality of life is improved for patients. participation in armor may involve retrospective data collection only, combined retrospective and prospective data collection, or prospective data collection


Eligibility criteria:
inclusion criteria: retrospective enrollment: - patients having undergone percutaneous, open or laparoscopic energy ablation of a renal mass. prospective enrollment: - patients scheduled to undergo, rather than having undergone, percutaneous, open or laparoscopic energy ablation of a renal mass. exclusion criteria: * patients not having undergone, or considered candidates for percutaneous, open or laparoscopic energy ablation of a renal mass * non-english speaking patients * patients under the age of 18.

Keywords: ablation quality of life (qol) kidney registry ablation of renal masses outcomes registry (armor) 13-116
prevention of urinary incontinence after prostatectomy

Conditions: Urinary Incontinence

Summary: urinary incontinence is a frequent complication after radical prostatectomy. rehabilitative treatments are frequently utilized to reduce incontinence. however, their efficacy has not been completely investigated. in this study the investigators will compare the effect of an early rehabilitation programme (instruction of the patient, pelvic floor muscle training, electrical stimulation and biofeedback) versus instruction of the patient only. the investigators hypothesis is that early rehabilitation programme is more effective than patient's instruction alone in preventing urinary incontinence after radical prostatectomy.


Eligibility criteria:
inclusion criteria: * men who will undergo radical prostatectomy for prostatic cancer exclusion criteria: * previous urinary and/or faecal incontinence * neurologic bladder * previous pelvic surgery

Keywords: prostatectomy prostatic cancer urinary incontinence exercise electric stimulation therapy counseling
portal hypertension using magnetic resonance elastography

Conditions: Portal Hypertension; Magnetic Resonance Imaging

Summary: this prospective study was conducted in a tertiary university hospital. the investigators researched the correlation between mre-assessed stiffness of the liver and spleen and the hepatic venous pressure gradient (hvpg) values. furthermore, the investigator evaluated whether mre-assessed stiffness reflected changes in portal hypertension (ph) after administering non-selective beta-blockers (nsbbs).


Eligibility criteria:
inclusion criteria: * diagnosed liver cirrhosis * requiring prophylactic treatment of esophageal varices exclusion criteria: * the coexistence of hepatocellular carcinoma * refractory ascites who regularly underwent large-volume paracentesis * the use of selective beta-blocker or carvedilol therapy for at least 4 weeks * undergoing liver transplantation * contraindication with magnetic resonance imaging
investigation and comparison of the effects of posture exercises on dysfunction, posture and balance in individuals with posterior edentulous and full-toothed temporomandibular disorder

Conditions: Temporomandibular Disorder

Summary: the aim of this study is to investigate the relationship between neck posture and balance in patients with posterior edentulous and full-toothed temporomandibular disorder and to compare the effectiveness of the physiotherapy program to be applied.

the study was planned as a quasi-experimental controlled study. a total of 26 patients with temporomandibular disorder, aged between 18-70 years, 13 of whom were in the posterior edentulous group (pdg) and 13 were in the fully toothed group (tdg), were included. posture exercises and manual therapy were applied to both groups twice a week for six weeks. mandibular range of motion, pain, muscle strength, deep neck flexor endurance, flexibility, shortness, range of motion (rom), pressure pain threshold (bae), psychological state, posture and balance were evaluated before and after exercise. the results of the study showed that six weeks of postural exercises and manual therapy provided significant improvement in all values (p\<0.05). a significant difference was found in pain, muscle strength, rom, bae and balance in pdg compared to tdg (p\<0.05). the results of the study showed that symptoms can be improved by giving posture exercises in patients with tempromandibular disorder. it was concluded that the improvement in pdg was higher than in tdg.

Eligibility criteria:
inclusion criteria: * being diagnosed with myofascial temporomandibular disorder according to the research diagnostic criteria for temporomandibular disorders * complaining of head or neck pain * having temporomandibular joint pain for at least 3 months * not having used an intraoral plaque before * able to follow the treatment protocol regularly * ability and willingness to communicate verbally exclusion criteria: * being positive for covid-19 * sports injuries * presence of trauma * whiplash * degenerative changes * signs or symptoms of disc displacement, osteoarthrosis or osteoarthritis of temporomandibular joint * post-operative conditions involving the cervical or temporomandibular region * burn involving the cervical region and the temporomandibular region * patients using analgesics or muscle relaxants up to 8 hours before the physical therapy procedure * those with hypermobility in cervical movements * those who have received physiotherapy or other treatment from the head / neck area in the last 12 months * acute infections or any systemic disorder * osteoporosis

Keywords: temporomandibular joint physiotherapy posture exercises posterior tooth loss
"parkinson aktiv - non-pharmacological treatments in an innovative parkinson's network"

Conditions: Parkinson Disease

Summary: the purpose of this study is to evaluate the efficacy of an online platform that allows neurologists and therapists to exchange therapy recommendations, communicate assessments and plan physical therapy, occupational therapy as well as speech and swallowing therapy for their patients.

the aim of this study is to enroll 185 patients in the intervention group and 185 patients in the control group. patients in the intervention group come from the same region (münsterland), the control group will consist of patients outside this region. the patients in the intervention group undergo therapies planned and coordinated through the online platform for 12 months. the patients in the intervention group will be evaluated using the pdq-39, updrs, h\&y as well as schwab \& england. the patients in the control group will be evaluated using the pdq-39.

Eligibility criteria:
inclusion criteria (intervention group): * idiopathic parkinson's disease with pharmacological treatment * 30 years old or older * place of residence: münsterland, tecklenburger land, kreis and stadt osnabrück * sufficient knowledge of the german language, should be able to understand the consent form exclusion criteria: * severe cognitive deficits * atypical parkinsonian disorders * participation in other studies

Keywords: activities of daily living disease management quality of life rehabilitation patient-centered care delivery of health care integrated care
perioperative sitagliptin medication for reduction of the inflammatory response associated with cardiopulmonary bypass

Conditions: Systemic Inflammatory Response Syndrome

Summary: sitagliptin is an inhibitor of the enzyme dipeptidylpeptidase-4 (dpp-4) and represents an established drug in type 2 diabetes mellitus treatment. however, sitagliptin may also have several antiinflammatory properties. within this study the investigators examine the effects of perioperative sitagliptin intake on the inflammatory response after cardiopulmonary bypass.

sitagliptin is an inhibitor of the enzyme dipeptidylpeptidase-4 (dpp-4) and represents an established drug in type 2 diabetes mellitus treatment. however, sitagliptin may also have several antiinflammatory properties. for example, it is known that dpp-4-inhibition prevents procalcitonin from being cleaved to a truncated form that lacks 2 amino acids. as the investigators described recently, truncated procalcitonin targets the crlr-ramp1-receptor on vascular endothelium and induces ve-cadherin-phosphorylation which leads to leakage of fluids and proteins from vessels. furthermore, many other immunoregulatory targets such as substance p, cxcl10 or nf-kb have been reported to be modified by dpp-4. therefore, it can be assumed that sitagliptin possibly represents a powerful drug in inflammatory circumstances. the aim of this study is to prove possible antiinflammatory properties by conducting an observational trial in cardiac surgery patients. all patients undergo cardiac surgery with the use of cardiopulmonary bypass (cbp) which is known to trigger a systemic inflammatory response syndrome (sirs). group 1 suffers from diabetes mellitus type two and regularly takes sitagliptin which is continued perioperatively. group 2 also suffers from diabetes mellitus type 2 but does not take sitagliptin. group 3 has no diabetes mellitus but also undergoes cardiac surgery. to determine the effect of sitagliptin under inflammatory conditions deep immune phenotyping and a cytokine assay is performed from blood withdrawals 24h after surgery. moreover, the sublingual microcirculation is measured two times after the operation. taking all measurements of the cellular immune system, the humoral immune system and the vasculature into account it should be possible to define the immunoregulatory effects of sitagliptin treatment more properly.

Eligibility criteria:
inclusion criteria: * age \>18 years * patients undergoing cardiac surgery with use of cbp and... * diabetes mellitus type 2 with sitagliptin treatment or, * diabetes mellitus type 2 without sitagliptin treatmet or, * no diabetes mellitus * written informed consent exclusion criteria: * diabetes mellitus type 1 * treatment with another dpp4-inhibitor * treatment with glp-1-analoga * emergency surgery * chronic or acute infection * pregnancy * participation in an interventional study trial within last 3 months * relationship to study investigators

Keywords: sirs, cardiac surgery, dpp4
beef in an optimal lean diet (bold) effects on cardiovascular disease (cvd) risk

Conditions: Hypercholesterolemia; Hypertriglyceridemia

Summary: the study is designed to assess the effects of a heart-healthy diet that includes lean beef as the primary source of high quality protein on risk factors for cardiovascular disease.


Eligibility criteria:
inclusion criteria: 1. bmi \> 20 and \< 37 2. ldl-c level between the 50th and 90th percentile (±5% for assay variation) according to nhanes data for sex and age (ex. for men: 128-177 mg/dl and for women: 121-172 mg/dl) 3. tg level \< 150 mg/dl exclusion criteria include: 1. self-reported history of myocardial infarction, stroke, diabetes mellitus, liver disease, kidney disease, and thyroid disease (unless controlled on medication) 2. high alcohol consumption (≥ 14 drinks/week) 3. intake of putative cholesterol-lowering supplements (psyllium, fish oil capsules, soy lecithin, niacin, fiber, flax, and phytoestrogens, stanol/sterol supplemented foods) 4. treatment with lipid-lowering agents (statins and fibrates) or blood pressure control medications 5. vegetarian diet 6. weight loss or gain ≥ 10% body weight in the previous 6 months, 7. lactation, pregnancy, or desire to become pregnant during the study

Keywords: lean beef cholesterol lipids diet intervention
dexamethasone for preterm labour

Conditions: Prematurity

Summary: the investigators sought to determine whether the incidence of neonatal respiratory distress syndrome (rds) in preterm fetuses is similar with 12- vs 24-hour dosing interval of dexamethasone.

the administration of glucocorticoids to accelerate fetal lung maturity in patients with preterm delivery plays an important role for obstetrics and neonatal care. many studies have shown that maternal administration of glucocorticoids has a significant beneficial effect in decreasing the incidence of respiratory distress syndrome (rds) in infants delivered at 28-34 weeks of gestation.

Eligibility criteria:
inclusion criteria: * all patient with threatened or established preterm labor between 28 - 34 weeks attended to our emergency unit exclusion criteria: * emergent obstetric conditions like: * antepartum hemorrhage in severe attack * antepartum eclampsia

Keywords: dexamethasone preterm labour respiratory distress
efficacy and safety of enteric-coated mycophenolate sodium in combination with two corticosteroid regimens for the treatment of lupus nephritis flare

Conditions: Lupus Nephritis

Summary: the study will investigate the efficacy and safety of enteric-coated mycophenolate sodium in combination with two different corticosteroid (cs) regimes for the induction of remission of a lupus nephritis flare. patients will be randomly allocated to standard cs regimen (group i) or to a reduced dose cs regimen (group ii)


Eligibility criteria:
inclusion criteria * male or female patients with systemic lupus erythematosus (sle)(at least 4 classification criteria) * aged ≥18 years, * proliferative lupus nephritis classified as isn/rps class iii or iv * renal biopsy within the last 24-month preceding the study entry * proteinuria defined as \>0.5 gram urine protein per gram urine creatinine at screening and baseline * clinical activity defined by one or more of the following changes in renal function: serum creatinine \>1.0 mg/dl (88.4 μmol/l) * microscopic hematuria defined as \>5 red cells per high power field * presence of cellular casts exclusion criteria * patients with calculated creatinine clearance \<30 ml/min (using the cockcroft-gault formula) * patients having received an intravenous (i.v.) corticosteroid bolus during the last 3 months, * patients having received oral or i.v. cyclophosphamide during the last 3 month * patients having received mycophenolate mofetil (mmf) within the preceding 3 months * use of any antibody therapy within the past 6 months * pregnant or nursing (lactating) women or women of child-bearing potential who are planning to become pregnant, or are not willing to use effective means of contraception throughout the study and during one month after the end of the study. * use of other investigational drugs within 1 month of enrollment (except for antibodies: within 6 months of enrollment * history of hypersensitivity to any of the study drugs or to drugs with similar chemical structures, * history of malignancy of any organ system, treated or untreated, within the past 5 years whether or not there is evidence of local recurrence or metastases, with the exception of localized basal cell carcinoma of the skin. other protocol-defined inclusion/exclusion criteria may apply.

Keywords: lupus nephritis enteric-coated mycophenolate sodium ec-mps myfortic
treatment of displaced radial neck combined with olecranon fractures

Conditions: Child

Summary: this study aimed to evaluate the outcomes of using absorbable rods and kirschner wires technique for severe displaced radial neck fractures combined with olecranon fractures in children.

the most common fracture in children is the elbow fracture, and the three most common elbow fractures are supracondylar, lateral condylar, and medial epicondylar fractures. elbow fractures are easy to diagnose and the treatment modalities are studied often. however, proximal radius fractures, which include radial neck and head fractures, remain challenging to diagnose and manage. in addition, proximal radius fractures are often combined with other fractures, most commonly, an olecranon fracture. most radial neck fractures can be treated conservatively if the displacement is less than 3 mm and the angle is less than 30º. however, for severe judet type iii and type iv radial neck fractures, surgery is inevitable. this study focused on radial neck fractures combined with an olecranon fracture. in this study, absorbable rods were used for fixation of radial head fractures, and with no need for removal of the inner fixation, we performed anatomy reduction via the same incision with direct vision of the olecranon, and we were able to fix the fractures with kirschner wires (k-wires). in this retrospective study, we aimed to evaluate a treatment method for severe displaced radial neck combined with olecranon fractures in children using a boyd incision, absorbable rods, and k-wires.

Eligibility criteria:
inclusion criteria: * open reduction of severe radial neck fractures combined with an olecranon fractures in the same elbow * fixation performed using absorbable rods and k-wires exclusion criteria: * single radial head fractures or single olecranon fractures * fixation performed with bands * old fractures, * boyd incision was not used, * guardians did not agree with the surgery

Keywords: kirschner wires absorbable rods radial neck fracture olecranon fracture
preliminary study on eye features of patients with malignant tumors

Conditions: Feature Elongation; Cancer Patients

Summary: based on the theory of traditional chinese medicine, this study collects eye features of white eyes through the white eye imaging health care system under visible light and establishes a database of eye-eye features corresponding to the disease. the computer image analysis and artificial intelligence technology are used to visualize the eye. the features were extracted and classified, and the corresponding changes in the characteristics of the traditional chinese medicine and the disease were analyzed statistically to establish an analytical model corresponding to the disease.

1. collecting the white-eyed eye features of 500 patients with malignant tumors and 500 non-tumor patients by the white-eye shadowless imaging acquisition system under visible light, and establishing eye-catching images of malignant tumor patients and healthy people of different diseases. feature database. 2. based on the collected four-dimensional eye-eye diagram, using computer image analysis and artificial intelligence technology to extract and classify the eye-eye features of the white eye, and statistically analyze the correlation between the eye-eye features and the malignant tumor. the relationship between the characteristics of the white eye and the corresponding change of malignant tumor.

Eligibility criteria:
inclusion criteria: * malignant tumor patients with clear pathological diagnosis; * those who have no serious primary diseases of the cardiovascular, cerebrovascular, respiratory, endocrine, urinary, blood and other systems; * the main organs (hematopoiesis, heart, lung, liver, and kidney) have no obvious abnormal function; ④age ≥18 years old, ≤75 years old; ⑤ no serious eye disease; * the patient volunteered to participate in this study. exclusion criteria: * patients with severe blood loss (because when the bleeding exceeds 300ml, the white eye color of the patient is often pale white); * poor patient compliance; ③ pregnant and lactating women; * can't cooperate with inspection properly; ⑤ cannot read or understand the scale.

Keywords: eye manifestations cancer
quality of life in binge eating disorder.

Conditions: Binge-Eating Disorder; Quality of Life

Summary: binge eating disorder (bed) patients tend to report low quality of life (qol). however, research is limited. most research on qol in bed include generic measures, rather than disease specific. obesity is prevalent in bed, but contradicting evidence exists on the influence of obesity in bed.

eating disorders (ed's) are a group of disorders characterized by abnormal eating behaviors ranging from insufficient to excessive food intake, with concurrent disturbances in thoughts and emotions. binge eating disorder (bed) is the most prevalent ed in both men and women, yet was only recently included in the diagnostic and statistical manual of mental disorders fifth edition (dsm-5) as a diagnostic entity. in general, ed's have been associated with significantly worse health related quality of life (hrqol) compared to healthy population. high rates of overweight (bmi ≥ 25) and obesity (bmi ≥ 30) are found in bed patients and obesity in itself is associated with lower qol. the most widely used tools to measure qol in ed's are the medical outcome studies short form (sf) scale, e.g. sf-36 and sf-12, which are generic in nature. generic qol measures have shown lack of sensitivity for some ed diagnoses and might not be suitable enough to pick up unique features that might characterize each disorder. the objective of this study is to evaluate quality of life in danish bed patients before treatment by using disease specific qol measure. furthermore, we want to assess the impact of obesity and depression on disease specific qol in bed patients. the hypothesis are that obesity and depression will be associated with an impaired level of disease specific qol.

Eligibility criteria:
inclusion criteria: 1. patients referred to treatment for bed at center f. eating disorders, ouh. exclusion criteria: 1. extremely severe bed. 2. severe psychiatric comorbidity.

Keywords: binge eating disorders quality of life
the incidence and risk factors of radiotherapy induced hypothyroidism in head and neck cancer with long term follow up

Conditions: Head and Neck Cancer

Summary: this is a retrospective study with long term follow up to evaluate the incidence, timing and risk factors of radiotherapy induced hypothyroidism in non-thyroid head and neck cancer patients who were treated with rt alone or in combination with surgery and/or chemotherapy.

for any patient, fixation was done by a thermoplastic mask. ct scan was done at 3mm thickness for the head and neck region. ct images were transferred to the planning system. three-dimensional conformal rt, intensity-modulated radiotherapy (imrt) or volumetric modulated arc therapy (vmat) was created. all patients were irradiated with once-daily fractionation at 1.8-2.0 gy/d with 6-mv photon beams for five days a week. the gross target volume (gtv) was treated with a dose of 70gy and the lymphatic site (ctv) and areas of high risk microscopic disease (ctv) including lymph nose levels received a radiation dose ranging from 54-66 gy according to its risk. ptv is a circumferential margin of 5mm around ctv. thyroid function parameters: the patient's serum t4, t3 and tsh levels, were measured during follow up. clinical hypothyroidism is defined as the increase in tsh above 5.0miu/ml with a decrease in free thyroxine levels (free t4) in the serum while elevated tsh with normal free t4 levels was labeled as subclinical hypothyroidism .as per institutional values, the normal values intervals of t4 level (7- 25 pmol/l), t3( 1.5-7 pmol/l),tsh (0.2-5 miu/l). the median time to onset of hypothyroidism was defined as the time interval between completion of radiotherapy and first abnormal recorded t3/t4/tsh value. for all treated patients, thyroid gland was delineated and by reviewing the dvh, the v45, v50, v55, v60, v65 and v70 which means the volume of the thyroid gland receiving 45 gy, 50 gy, 55gy, 60 gy and 70 gy respectively.

Eligibility criteria:
inclusion criteria: * non-thyroid head and neck cancer patients who were treated with rt alone or in combination with surgery and/or chemotherapy exclusion criteria: * patients with thyroid gland disease or abnormal thyroid hormone levels before radiotherapy

Keywords: hypothyroidism radiotherapy head and neck cancer