Kornimate/medical-research-clean huggingface dataset:
test and treat tb: a proof of concept trial in south africa

Conditions: Tuberculosis

Summary: the purpose of this study is (1) to establish the feasibility, yield, and clinical impact of a "test \& treat tb" strategy on a mobile hiv screening unit in south africa and (2) to assess the cost and cost-effectiveness of this mobile, integrated hiv/tb screening strategy for maximizing linkage to tb care and treatment completion.


Eligibility criteria:
inclusion criteria: * english or zulu speaking * presenting for screening at mobile unit * voluntarily undergoing hiv testing * able and willing to give informed consent * willing to share hiv and tb test results * willing to attend one of six local clinics for treatment * access to a mobile phone exclusion criteria: * pregnant

Keywords: tb hiv test and treat linkage
prospective clinical validation of a novel multitarget fit in crc screening

Conditions: CRC; Advanced Neoplasia

Summary: the primary goal of the population-based colorectal (crc) screening is early detection and interception of crc and its precursors to decrease crc-related morbidity and mortality. to improve current crc screening programs, the investigators have developed and retrospectively validated a test that combines the detection of multiple proteins in stool (the multitarget faecal immunochemical test, mtfit). mtfit was found to have a higher accuracy to detect advanced neoplasia (an), which includes crc, advanced adenomas and advanced serrated polyps, in comparison to fit. thus, this multitarget test has the potential to improve the screening program's efficiency in reducing crc-related incidence, morbidity and mortality. this new test, in comparison to fit, shows specifically higher sensitivity in the detection of advanced adenomas, without affecting specificity.

background: the primary goal of population-based crc screening is early detection and interception of crc and its precursors to decrease crc-related morbidity and mortality. new tests, with higher sensitivity for advanced precursor lesions than the current fit, are desired. the investigators have developed a protein-based multitarget faecal immunochemical test (mtfit) that shows higher sensitivity for advanced adenomas without losing in specificity. objective: to prospectively validate the better performance of the mtfit in comparison to fit in the setting of a population-based crc screening program. material and methods: in this prospective study, participants of the dutch national crc screening program (55-75 years of age) will be invited to participate. individuals who consent to participate in the study, will be asked to take two stool samples from the same bowel movement. in a central laboratory these two samples then will be analyzed. one with the standard of care faecal immunochemical test (fit) and the other with the multi-target faecal immunochemical test (mtfit). if either one of these two tests is positive, individuals will be referred to undergo a colonoscopy procedure. the performance of mtfit, in comparison to fit, will be evaluated against the colonoscopy findings. expected results: mtfit has higher sensitivity for an, and in particular advanced adenomas, than fit, at equal positivity rate.

Eligibility criteria:
inclusion criteria: * individuals of the dutch population suitable for crc screening (age between 55 and 75 years old) will be randomly selected. * the participants will be invited in phases and are selected out of different age groups. * the selected participants will participate in the population crc screening program for either the first, second, third or fourth time. exclusion criteria: * collection of stool not complete for both tests (fit and mtfit)
one-visit root canal treatment using chlorhexidine as a final irrigant

Conditions: Root Canal Infection

Summary: a hundred asymptomatic molar teeth with periapical lesions were treated in single versus multiple visit root canal treatment. half of the teeth were randomly assigned to the one-visit (ov) group and received an additional final rinse with 2% chx before obturation. the other teeth were treated in two visits (tv) with calcium hydroxide dressing. all patients were recalled and investigated clinically and radiographically for 48 months

the aim of the study was to evaluate the radiographic evidence of periapical healing in teeth with apical periodontitis treated in a single visit with an additional final irrigation using 2% chlorhexidine and to compare the results with conventional multiple-visit root canal treatment (rct) with an intracanal calcium hydroxide dressing as a control group. 100 asymptomatic molar teeth with periapical lesions were treated using engine-driven nickel-titanium (niti) instrumentation with 2.5% sodium hypochlorite (naocl) and 5% ethylenediaminetetraacetic acid (edta) as irrigants. half of the teeth were randomly assigned to the one-visit (ov) group and received an additional final rinse with 2% chlorhexidine (chx) before obturation. the other teeth were treated in two visits (tv), after completion of root canal instrumentation calcium hydroxide paste was placed into the root canal and root canal obturation was performed in second visit. all patients were recalled and investigated clinically and radiographically for 48 months. changes in apical bone density indicating radiographic healing were evaluated.

Eligibility criteria:
inclusion criteria: * with a non-contributory medical history, * mature molar teeth with periapical lesions, * diagnosed as asymptomatic apical periodontitis exclusion criteria: * clinical symptoms, drainage, * more than 5 mm loss of periodontal attachment, * previous endodontic treatment, * non-restorable tooth

Keywords: chlorhexidine one visit root canal treatment
robotic versus laparoscopic surgery for deep endometriosis

Conditions: Endometriosis; Deep Endometriosis; Surgery

Summary: the objective of this study is to examine whether robot-assisted laparoscopy is superior compared to conventional laparoscopy as regards to patient outcome.

the objective of this prospective, randomized trial is to examine whether robot-assisted laparoscopy is superior compared to conventional laparoscopy as regards to patient outcome at 6, 12 and 24 months postoperatively, measured by questionnaires concerning the pain symptoms and disease-related quality-of life.

Eligibility criteria:
inclusion criteria: * asa (american society of anesthesiologists physical status classification) 1-3 * diagnosed deep endometriosis (mri) * patient has symptoms * operative treatment is indicated * patient is able to give informed consent exclusion criteria: * asa \> 3 * recurring rectosigmoid endometriosis

Keywords: endometriosis surgery deep endometriosis surgery robotic surgery
a phase 1b study of iv prm151 in patients with idiopathic pulmonary fibrosis (ipf)

Conditions: Idiopathic Pulmonary Fibrosis

Summary: the aims of the study are to assess safety, tolerability, the pharmacokinetic profile, and the pharmacodynamic profile of multiple doses of prm-151 administered iv to ipf patients.

idiopathic pulmonary fibrosis (ipf) is a diffuse lung disease with a histological picture of usual interstitial pneumonia and a deteriorating clinical course. the prognosis is poor. chronic alveolar inflammation with associated parenchymal remodeling is theorized to promote an ongoing abnormal fibrogenic repair response. corticosteroids and immunomodulatory agents have not been shown to benefit ipf patients. recently several published clinical studies have indicated a strong correlation between ipf severity and/or disease progression and the levels of specific plasma biomarker proteins related to epithelial cell health and extracellular matrix turnover. prm-151 is being developed for potential therapeutic uses to prevent, treat, and reduce fibrosis. this study is the first intravenous multiple-dose study in humans, and will be conducted in patients with ipf. patients will be randomized to receive either prm-151 or placebo.

Eligibility criteria:
inclusion criteria: * men or women of non-childbearing potential aged 40 to 80 years at screening. * diagnosis of idiopathic pulmonary fibrosis (ipf) as determined by high resolution computerized tomography (hrct) and pulmonary function tests. exclusion criteria: * history or presence of connective tissue disorder, tuberculosis (tb), cystic fibrosis, sarcoidosis, amyloidosis or other pulmonary disease except idiopathic pulmonary fibrosis (ipf). * history or presence of chronic pulmonary obstructive disease, severe pulmonary hypertension, drug-induced pulmonary toxicity, other forms of idiopathic pneumonia, or interstitial lung diseases associated with environmental exposure medication or systemic disease. * high resolution computerized tomography (hrct) findings inconsistent with idiopathic pulmonary fibrosis(ipf).

Keywords: pulmonary, fibrosis
study on the microrna expression level in postmenopausal osteoporosis

Conditions: Postmenopausal Osteoporosis

Summary: the mirna plays an important regulation role in gene expression, and also closely related to bone metabolism. previous research found that postmenopausal osteoporosis with kidney yin deficiency syndrome (pop) is associated with clcf1 gene. this project proposed by bioinformatics prediction clcf1 targeted regulation of mirnas, and use the 3 'utr dual luciferase report system for target validation, aimed at the mirna levels to explore postmenopausal osteoporosis molecular mechanism with kidney yin deficiency syndrome.


Eligibility criteria:
inclusion criteria: * the participants who volunteer to be test subjects, and can accept experimental drugs, and promise to finish the course should sign the informed consent. * female ages 45 to 75 had gone through natural menopause before two years * in accordance with the western medicine diagnostic criteria of osteoporosis and belong to kidney yin deficiency syndrome differentiation of traditional chinese medicine certificate; * in accordance with the western medicine diagnostic criteria; * in accordance with tcm diagnostic methods; .if any of the above answers are no, the subjects couldn't in the study. exclusion criteria: * do not accord with standard of the western medicine diagnosis and tcm diagnostic methods * age: \ 76 years old; * with hyperparathyroidism, osteomalacia, rheumatoid arthritis, multiple myeloma and other serious complications such as secondary osteoporosis; late or deformity, disability, loss of labor; * with cardiovascular, cerebrovascular, liver, kidney and hematopoietic system and other serious primary diseases; * psychosis or alzheimer's patients; * nearly three months, the use of hormone replacement therapy (hrt) and taking calcitonin, nearly six months has used double phosphonic acid salt for 15 days, etc.; * this medicine allergic constitution or composition of known to have allergies; * in a critical condition, it's difficult to make exact evaluators to efficacy and safety of the new drugs;
rn-led palliative and supportive care intervention

Conditions: Acute Myeloid Leukemia

Summary: this single institution feasibility and acceptability study includes patients with acute leukemia which is designed to examine a novel palliative and supportive care intervention (palliative and supportive care intervention; pact) in which registered nurses (rns), occupational therapists (ots), and physical therapists (pts) address the activity needs of older adults with acute leukemia during their hospital stay.

the primary objective of the study is to assess feasibility, acceptability, and change in pre and post measures of symptoms, function, and qol by administering the pact intervention. the first 20 participants in the control group will receive usual care. the next 20 participants will receive the pact intervention. each participant in the intervention group will be cared by a collaborative, multidisciplinary, integrated team including rns, ots and pts.

Eligibility criteria:
\[patient\] inclusion criteria: 1. ≧60 years of age 2. diagnosis of acute myeloid leukemia 3. receive low-dose cytarabine or hypomethylating agent (hma) in combination with venetoclax chemotherapy 4. speak and read english 5. preference will be given to patients with care partners exclusion criteria: 1. patients receiving hospice care \[caregiver\] inclusion criteria: 1. ≧18 years of age 2. identified by patient as caregiver 3. speak and read english

Keywords: symptoms function quality of life acute myeloid leukemia palliative care supportive care
phenotypic and genotypic characterization of new-onset type i diabetes

Conditions: Type1diabetes

Summary: the goal of diatag study is the identification of biomarkers of t1d evolution in a pediatric cohort.

type 1 diabetes (t1d) is a common chronic disease in childhood. clinical presentation at onset of t1d can vary among patients from long-standing diabetes triad symptoms (polyuria, polydipsia and weight loss) to coma and ketoacidosis. the initial clinical presentation of t1d was shown to have long-term influence on glycemic control of the patient. the investigators initiated a collaborative consortium including six pediatric clinics in belgium to better characterize new-onset t1d patients. hypothesis : 1. different subgroups of t1d patients might exist, underlying different physiopathology of t1d : * the investigators will first investigate the presence of biomarkers in different fluids (e.g. urine, blood, feces,...). * the investigators will correlate results with clinical parameters of glycemic control. dynamic tests (homa and stimulated c peptide) will be realized at 2 defined time points of the follow-up. 2. glucose variability can be influenced by external factors (e.g. diet, physical activity, quality of life (qol),...) the investigators will evaluate those external factors using approved questionnaires. they will presented to the patient and its parents at 2 defined time points.

Eligibility criteria:
inclusion criteria: 1. type 1 diabetes de novo according to american diabetes association criteria: 1. polyuria, polydipsia, weight loss ± ketoacidosis 2. fasting blood glucose ≥126 mg/dl and/or blood glucose ≥200 mg/dl at the 120th minute of an oral glucose tolerance test (ogtt) and/or hba1c ≥6.5% and/or a patient with symptoms of hyperglycemia/hyperglycemic crisis (see 8. a. 2.) with random blood glucose ≥200 mg/dl. 3. presence in the serum of one or more anti-islet autoantibodies (anti-insulin, anti-ia2, anti-gad65, anti-znt8) 2. age between 6 months and 18 years. 3. male or female. 4. positive for one or more autoantibodies typically associated with type 1 diabetes (td1). 5. free written and oral consent. exclusion criteria: 1. children under 6 months of age. 2. treatment that interferes with insulin secretion and insulin sensitivity (e. g. sulfonylureas, diazoxide, somatostatin, methylxanthine derivatives, corticosteroids, biguanide, incretins). 3. presence of celiac disease (diagnosis based on pathological duodenal biopsy), recently diagnosed (within 1 month), at the time of inclusion. 4. autoimmune/auto-inflammatory disease (other than type 1 diabetes) or active malignant disease present at inclusion. 5. obesity defined by a body mass index (bmi) with a z-score \>+3 standard deviation. 6. hepatic, renal or adrenal insufficiency. 7. history of spinal cord allograft. 8. history of post-hemolytic-uremic diabetes. 9. absence of anti-pancreatic islet auto-antibodies. 10. dysmorphic with suspicion of underlying genetic syndrome. 11. participation in another study within the previous 3 months, with administration of blood derivatives or potentially immunomodulating treatments.

Keywords: type 1 diabetes children biomarkers
time interval for changing closed system suction catheters, effect on ventilator associated pneumonia

Conditions: Pneumonia, Ventilator Associated; Closed System Suction Catheter

Summary: the purpose of this study was to compare the incidence of ventilator-associated pneumonia between two groups of patients randomised to have closed system suction catheter changes every 24 hours and patients having closed system suction catheter changes every seven days or as required.

comparison(s): the incidence of ventilator-associated pneumonia between two groups of patients randomised to have closed system suction catheter changes every 24 hours and patients having closed system suction catheter changes every seven days or as required.

Eligibility criteria:
inclusion criteria: * aged greater than 18 years * mechanically ventilated for more than 24 hours exclusion criteria: * admitted from other hospital already mechanically ventilated * massive haemoptysis * previously received mechanical ventilation
comparative safety and efficacy study of new bifonazol spray vs terbinafine solution vs placebo

Conditions: Tinea Pedis

Summary: the study shall prove whether 6 consecutive doses of bifonazole spray show comparable efficacy to a terbinafine solution applied once.


Eligibility criteria:
inclusion criteria: * male or female subjects aged between 18 and 70 years * positive clinical findings of athlete's foot, limited to interdigital spaces, with a total athlete's foot severity score (afss) of at least 5 and not exceeding 10 points for the signs and symptoms of athlete's foot, and no sign or symptom scoring 'severe' exclusion criteria: * clinical history suggestive of intolerance or allergies to one of the products or the ingredients of the products * plantar tinea pedis ("mocassin-type") * onychomycosis of any toe * previous treatment with a systemic antifungal within 6 months prior to screening * previous treatment of feet with a topical antifungal within 4 weeks prior to screening * previous treatment with a topical antifungal applied to other areas of the body than feet within 2 weeks prior to screening * previous treatment of any topical medication applied to the feet within 2 weeks prior to screening

Keywords: bifonazole terbinafine reduced treatment duration efficacy safety athlete's foot moderate severity
endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic lesions with rapid staining of cytological smears followed by whole slide scanning and artificial intelligence diagnosis: a prospective, multicenter study.

Conditions: Pancreatic Disease

Summary: the objective of this observational study is to investigate whether the self-developed whole slide scanning and artificial intelligence diagnostic system for pancreatic solid lesion puncture cytopathology (hereinafter referred to as the "zhiying shunxi" rose-ai diagnostic system) can promptly and accurately diagnose solid pancreatic lesions (spls). the main question it aims to answer is: by utilizing optical imaging technology to capture rgb images of diff-quik stained smears from pancreatic punctures, can the development of artificial intelligence algorithms assist in differentiating solid pancreatic space-occupying diseases (such as pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumors, and non-neoplastic benign lesions)? researchers will compare the diagnoses of spls made by the rose-ai system with the actual pathological diagnoses of the spls themselves to determine whether the rose-ai system can effectively diagnose spls.


Eligibility criteria:
inclusion criteria: * a dated and signed informed consent form a commitment to abide by the research procedures and cooperate throughout the entire study subjects aged 18 and above, regardless of gender diagnosis or suspicion of a solid pancreatic space-occupying lesion based on imaging studies (b-mode ultrasound, ct, or mri) exclusion criteria: * unable or refusing to sign the informed consent form unable to suspend anticoagulation/antiplatelet therapy pregnant or lactating having a mental illness or other medical conditions that are unsuitable for undergoing fna/b biopsy presence of coagulation disorders (plt \ 1.5) pancreatic cystic lesions non-diagnostic eus-fna/b specimens having less than 8 microscopic fields of interest (roi) in the digital pathology images of the entire diff-quik smear slide
efficacy and safety of non invasive vagal stimulation to prevent chemotherapy-induced nausea

Conditions: Breast Cancer

Summary: despite pharmaceutical innovations, chemotherapy induced nausea is frequent and largely participating to alter our patients quality of life. non invasive vagal stimulation is approved in other health issues, for example in headache or gastroparesis, with a reported benefit on nausea. this study aims to analyse if a non invasive vagal stimulation could better prevent chemotherapy induced nausea, in addition to standard treatment, in breast cancer patients treated with cyclophosphamide and anthracycline.

despite pharmaceutical innovations, chemotherapy induced nausea is frequent and largely participating to alter our patients quality of life. non invasive vagal stimulation is approved in other health issues, for example in headache or gastroparesis, with a reported benefit on nausea. this study aims to analyse if a non invasive vagal stimulation could better prevent chemotherapy induced nausea, in addition to standard treatment, in breast cancer patients treated with cyclophosphamide and anthracycline.

Eligibility criteria:
inclusion criteria: * eastern cooperative oncology group (ecog) status 0 to 2 * patient with breast cancer planned to receive anthracycline and cyclophosphamide chemotherapy * informed consent * compliance expected * social security affiliation exclusion criteria: * nausea or vomiting 24h or less, before inclusion * antiemetic drug intake in the last 72h before inclusion * central nervous system metastasis * daily alcohol intake * prior chemotherapy * cardiac arrythmia, severe heart failure * device for sleep apnea * history of arterial or venous thrombosis, or thrombophlebitis * vagotomy * vagal stimulation ongoing * skin disease on the stimulation zone * cochlear implant next to the stimulation zone * unable to use the vagal stimulation device due to left ear unusual shape * pregnant or breastfeeding women, or women of childbearing age without effective contraception * documented allergy or contraindication to one of the antiemesis drugs required in the study * protected adults (individuals under guardianship by court order) * unable to read or write

Keywords: nausea non invasive vagal stimulation chemotherapy breast cancer
identification of predictive factors for survival of patients with recurrent prostate cancer from clinical features, tissue image features and molecular biomarker data

Conditions: Prostate Cancer

Summary: we seek to improve the predictive accuracy of the nomogram to predict survival for patients with castrate mets disease through the addition of pathological data, the results of automated machine vision based image analysis of h\&e stained tumor tissue developed at aureon biosciences,and molecular biomarker studies (25 markers) determined by immunohistochemistry on tissue microarrays prepared from paraffin-embedded tumor.


Eligibility criteria:
inclusion criteria: patients in the first retrospective study (stage 1) must be part of the 409 patient strong mskcc cohort with progressive metastatic prostate cancer which was used for the generation of the original nomogram. for details please see original publication by smaletz et al. patients involved in the second retrospective study (stage 2) must be part of the 223 patients with a rising psa after surgery or radiation therapy who were treated on conjugate vaccine trials at mskcc.. exclusion criteria: for details of excluded patients on the clinical metastases castrate disease study, please see original publication by smaletz et al.4 • (mskcc - add reference if publication available for rising psa patients)

Keywords: castration resistant prostate cancer progressive castrate metastatic prostate cancer