Kornimate/medical-research-clean huggingface dataset:
the effects of transcutaneous electrical nerve stimulation on people with knee osteoarthritis (oa) and or chronic pain

Conditions: Knee Pain

Summary: the purpose of this study is to evaluate the effect of tens at the knee pain.


Eligibility criteria:
inclusion criteria: * male or female between the ages of 45 years or older * ultrasonography scale of 0-3 for grading of primary knee oa of the knee(s) * pain perceived as a minimum of 3/10 on a 0-10 pain scale with 24 hours of the each visit * no phobia of electrical stimulation * no pain or anti-inflammatory medication will be taken during study * oa and or chronic knee pain, injury/pain that began minimum of 6- weeks before the beginning of the study. exclusion criteria: * pregnancy * diabetes mellitus * neuropathy * smoker * uncontrolled htn * past surgery in the region to be treated by tens or had received an intra-articular corticosteroid or hyaluronic acid injection within 6 months prior to enrollment * arthritis (ra) in the area to be treated by tens * allergic to tape/electrodes * dementia * history of knee joint replacement or tibial osteotomy * undergoing physical therapy * any major joint pain (e.g., back, hip, or ankle) that could limit functional ability * contraindications to tens (pacemakers, dermatological conditions, and abnormal sensation in the knees) * severe medical or neurological conditions (e.g. chronic obstructive pulmonary disease, cardiovascular disease, arteriosclerosis obliterans, cerebrovascular accident, lumber disc, herniation, and rheumatoid arthritis) * the subject does not utilize stairs in daily living * the subject is unable to walk without ambulatory assistive devices.
obesity-asthma endophenotype and diaphragm mobility in adolescence

Conditions: Obesity; Asthma

Summary: obesity and asthma share changes that may begin in the fetal development phase. the endophenotype obesity-asthma presents as main characteristic a pattern of inflammatory response different from the habitual th2 profile of cytokines. in these obese patients, possible changes in the diaphragm muscle can directly influence the dynamics of pulmonary ventilation significantly. due to the importance of the diaphragm in pulmonary ventilation, this study will be performed to verify possible alteration in the excursion and diaphragmatic thickness of adolescents with endophenotype obesity-asthma. in parallel, the possible underlying etiopathogenic substrate of this endophenotype will be explored through the dosing of muscle enzymes and inflammatory cytokines and obesity hormones.


Eligibility criteria:
inclusion criteria: * adolescents of both sexes, aged 12-21 years; * for the obesity groups, bmi for gender and age equal to or greater than the 97th percentile; * clinical diagnosis of persistent, moderate and severe asthma by a specialist physician and its severity classified according to the gina (global initiative against asthma) criteria. exclusion criteria: * adolescents with a diagnosis of cardiovascular, rheumatic, osteoarticular, neuromuscular or any other disease that limits the safe performance of the tests proposed by the protocol will be excluded; and those who do not agree to participate in the study.

Keywords: obesity asthma diaphragm excursion pulmonary function test
oral antidiabetic agents in pregnancy

Conditions: Gestational Diabetes

Summary: the aim of this study is to determine the efficacy of oral treatment with glyburide and metformin controlling excessive fetal growth in women with gestational diabetes, using insulin as a ransom on no response to oral treatment . it is randomized with women who seek care at the outpatient diabetes in pregnancy in our hospital trial eligible women between 18 - 45anos diagnosed with gestational diabetes , according to the who criteria , ratified the public network for prenatal care at the clinic for diabetes and pregnancy hcpa . women with singleton pregnancy and gestational age not exceeding 30 weeks at the time of enrollment. pregnant women with indication for pharmacological treatment will be invited to randomization to use of oral , glyburide or metformin antidiabetic . at regular intervals of 2 - 3 weeks fetal growth will be measured with obstetric ultrasonography , until birth. the primary outcomes will be : ( 1 ) weight and gestational age at birth and the index of large for gestational age fetuses ( ≥ 90th percentile for gestational age ) ( 2 ) the use of insulin to achieve glycemic targets according to fetal growth , as an indirect measure of the inefficiency of oral medications .

the procedures for monitoring metabolic and obstetrical control , assessments of fetal well -being and indications for interruption are usually adopted in the outpatient diabetes and pregnancy of the institution. - patients will be followed since their first appointment in our hospital, around the 20th week of pregnancy- until 8 weeks after labor and delivery. that being said, patients will be followed by an average of 28 weeks.

Eligibility criteria:
inclusion criteria: * eligible women between 18-45 years diagnosed with gestational diabetes, according to the who criteria (19), ratified the public network for prenatal care at the clinic for diabetes and pregnancy. * women with singleton pregnancy and gestational age not exceeding 30 weeks at the time of enrollment, calculated from ultrasound (u.s.) obstetric performed before the 20th week of pregnancy will be enrolled. exclusion criteria: * women who present enrollment in the diagnosis of chronic hypertension, heart disease or chronic lung disease intrauterine restricted or preterm labor, growth, or even chronic diarrhea will be excluded

Keywords: gestational diabetes metformin glyburide fetal growth capillar glucose
lobaplation or cisplatin in adjuvant chemotherapy for esophageal carcinoma

Conditions: Esophageal Cancer

Summary: the multicenter real-world and propensity score matching comparative study was designed to explore the toxicity and effectiveness of lobaplation or cisplatin based adjuvant chemotherapy in esophageal carcinoma

this trial is a multicenter real-world retrospective comparative study. the patients with thoracic esophageal squamous cell carcinoma, esophagectomy and adjuvant chemotherapy(cisplatin plus docetaxel or lobaplatin plus docetaxel) from 6 centers in china were enrolled from jan.2013 to dec.2016. completed clinical and pathological data were collected from large-scale data analysis center of cancer precision medicine-linkdoc database and analyzed by using data technology support from linkdoc by using r-language. a hybrid solution for extracting structured medical infromation from unstructured data in medical records via a double-reading/entry system. the world health organization (toxicity grading scale for determining the severity of adverse events) was used. the side effects of adjuvant chemotherapy and overall survival rate were compared by a propensity score. the 6 centers are the affiliated cancer hospital of zhengzhou university/henan cancer hospital, anyang cancer hospital, anhui province hospital, the first affiliated hospital of anhui university, tangdu hospital/the affiliated hospital of fourth military medical university, the first affiliated hospital of xi'an jiao tong university.

Eligibility criteria:
inclusion criteria: * i) thoracic escc stage ii to iii; ii) without any preoperation treatment for escc; iii) underwent r0 resection; iv) received ajuvant chemotherapy of cisplatin plus docetaxel or lobaplatin plus docetaxel. exclusion criteria: * i) with ajuvant radiotherapy/chemoradiotherapy; ii) history of other type of cancer iii) without completed clinical, pathological and follow up data.

Keywords: adjuvant chemotherapy multicenter retrospective study
the relationship between body mass index and periodontitis

Conditions: Obesity; Periodontitis

Summary: this study aimed to examine the relationship between body mass index (bmi) and stage/grade of periodontitis per the current classification of periodontal diseases. 142 patients (82 males/60 females) were included in this study. "2017 world workshop on the classification of periodontal and peri-implant diseases and conditions" was taken as basis to characterize the stage/grade of periodontitis. as well as age, gender, smoking status, and frequency of tooth brushing, medical data of the patients including hypertension, hyperlipidemia, bmi, and diabetes mellitus were obtained from the patient's hospital records. obesity was assessed by bmi using the "world health organization" criteria.

in this retrospective study, dental and medical records of 200 patients diagnosed with periodontitis who applied to baskent university, faculty of dentistry, department of periodontology between january 2019 and january 2021 were reviewed. fifty three patients were excluded due to unclear or missing data, and five subjects were not included as they were under the age of 18. the final study population therefore consisted of 142 patients (82 males/60 females). as well as age, gender, smoking status, and frequency of tooth brushing, medical data of the patients including hypertension, hyperlipidemia, bmi, and diabetes mellitus were obtained from the patient's hospital records. periodontal records of the patients were obtained for six different sites (mesio-buccal, mid-buccal, disto-buccal, mesio-lingual, mid-lingual, and disto-lingual) per tooth. mean ± standard deviation (sd) and median (minimum-maximum) were utilized for quantitative variables, and number of patients (percentage) were utilized for qualitative variables as descriptors. for quantitative variables, kruskal-wallis h test was performed to see whether there was a statistically significant difference between categories of the qualitative variable with more than two categories. chi-square test was used for investigating the relationship between two qualitative variables. for determining the risk factors considered to have an effect on the dependent quantitative variable, univariate and multivariate logistic regression analyses were performed. statistical significance level was defined to be 0.05.

Eligibility criteria:
inclusion criteria: * patients diagnosed with periodontitis who applied to baskent university, faculty of dentistry, department of periodontology between january 2019 and january 2021 exclusion criteria: * being under the age of 18, * being pregnant, * having used antibiotics within the past 3 months, * having missing data in dental and medical records.
effects of gw679769 on sleep onset and maintenance,and next day functioning in the elderly and non-elderly with primary insomnia

Conditions: Sleep Initiation and Maintenance Disorders; Insomnia

Summary: this study is designed to find the optimal (best) doses of gw679769 that promote sleep onset and maintain sleep during two consecutive nights of dosing without significant next-day thinking impairment and drowsiness in subjects with primary insomnia.


Eligibility criteria:
inclusion criteria: * difficulty going to sleep and/or staying asleep for at least the past 3 months. * insomnia must result in significant distress or impairment in functioning at home, socially or at work. * otherwise good health with no significant or unstable medical disorder including psychiatric, neurological, endocrine, heart, lung or gastrointestinal disorders, drug/alcohol abuse, cognitive impairment, cancer or chronic pain conditions such as arthritis. exclusion criteria: * history of other sleep disorders such as sleep apnea or restless leg syndrome. * regular sleep habits, including bedtime between 9 pm and midnight. * nightshift/rotating shift work, frequent napping or planned travel across \>2 time zones. * use to moderate use of nicotine, caffeine and alcoholic products.

Keywords: polysomnography electroencephalography primary insomnia cognition sleep
markers of bone turnover in saliva and how this compares to urine and blood

Conditions: Bone Turnover Markers; Osteoporosis

Summary: study is being done to determine if it is possible to use saliva to measure bone specific proteins and predict bone turnover which could be used in the treatment of osteoporosis.

prevention and treatment of osteoporosis require sensitive and specific assays of bone turnover. presently, serum or urinary assessments are used. however, the development of other procedures that are more patient-convenient, non-invasive and cost-efficient would significantly facilitate a clinician's ability to determine bone turnover. the objective of this application is to determine the feasibility of using saliva for this measurement. we will compare serum, urinary and salivary levels in 50 pre- and 50 post-menopausal women. markers to be measured are bone alkaline phosphatase, osteocalcin, procollagen type propepties hydroxypyridinium crosslinks of collagen and crosslinked collagen telopeptides. collection of saliva, serum and urine will be done at a single visit. we expect to observe reasonable good correlation between serum and saliva levels and poorer correlation between urine and saliva levels.

Eligibility criteria:
inclusion: * 50 pre-menopausal females (25-40 yo) * 50 post-menopausal females (55-70 yo) * good systemic health * good oral health exclusion: * arthritis * active periodontitis * history or actively smoking * diabetes * hiv positive * anti-coagulant therapy * bone fracture within the past year * pregnancy * known metabolic bone disease
neck motion and motor control in chronic neck pain and associations with clinical symptoms

Conditions: Neck Pain

Summary: the primary purpose of this study is to investigate if there is altered motor control of head and neck in chronic neck pain patients compared with healthy persons. in addition, associations between neck pain, motor control, disability and function, and clinical symptoms will be studied in patients following physiotherapy treatment in primary health care.


Eligibility criteria:
inclusion criteria: * idiopathic neck pain with duration \>2 weeks * normal or corrected vision * pain at or above 3 on numeric rating scale, with "low pain" defined as 3-4 and "high pain" as 5 or higher. exclusion criteria: * systemic or diagnosed chronic disease, including diabetes, stroke and neurological diseases, that may influence motor control and neck pain or ability to perform tests * positive spurling test for neurological radiating arm pain * pregnancy * whiplash * insufficient comprehension of norwegian language

Keywords: neck movement motor control disability psychological variables head movements physical therapy fear avoidance self efficacy catastrophizing fly test postural sway
retrospective and prospective observational study in patients with advanced basal cell carcinoma

Conditions: Basal Cell Carcinoma

Summary: retrospective and prospective observational study in patients with advanced basal cell carcinoma.

basal cell carcinoma (bcc) is an epithelial tumor characterized by the malignant proliferation of keratinocytes in the basal layer of the epidermis. it is part, along with squamous cell carcinoma (scc),non-melanoma skin cancer (nmsc) and accounts for 80% of all skin cancers and the most common skin cancer in the united states and europe. estimates of bcc incidence, however, are inaccurate since in most countries there is no cancer register collecting data on bcc incidence and many patients are treated on a territorial outpatient basis, making data collection and epidemiological analysis complex. in recent decades, there has been an increasing trend in patients with bcc, as well as a reduction in the average age of onset, with a consequent drastic increase in the social and economic cost of healthcare facilities. from these considerations, arises the need to investigate and characterize the profile of patients with advanced bcc, the clinical characteristics and the course of such neoplasm, and the choice of therapeutic options available.

Eligibility criteria:
inclusion criteria: 1. male and female patients aged ≥ 18 years 2. patients diagnosed with advanced basal cell carcinoma of the skin, i.e. tumours included in at least one of the following categories: locally advanced carcinoma (not radically treatable by surgery and/or radiotherapy), carcinoma with lymph node and/or distant metastatic localisation 3. patients who have had at least one access (first visit or follow-up visit) at the dermatology or oncology outpatient clinic of the centres involved * patients diagnosed with advanced bcc who have accessed the centre from 1 january 2016 until the date of activation of the centre will be included in the retrospective cohort; * patients diagnosed with advanced bcc who have accessed the centre from the date of activation 4. signature of informed consent exclusion criteria: patients incapable of giving informed consent
outcomes and safety of various conduction system pacing methods

Conditions: AV Block; Bundle-Branch Block; Atrial Fibrillation Rapid

Summary: the aim of this study is to evaluate safety and clinical outcomes after different pacing approaches of conduction system pacing in a prospective registry.

in comparison with right ventricular pacing-induced electromechanical dyssynchrony, conduction system pacing is providing physiological pacing via his-purkinje activation. current approaches include his bundle (hbp), left bundle branch area pacing (lbbap), and bachmann bundle pacing. in addition, hbp and lbbap enable correction of underlying proximal bundle branch block, consequently improving the ventricular activation time and narrowing the qrs. furthermore, atrial activation can be improved with direct bachmann bundle stimulation. however, the data regarding long-term performance and safety of these physiological approaches in various clinical scenarios is scarce. with this registry, the investigators would like to obtain real-world data regarding the feasibility and safety of this physiological pacing approaches in various pacing indications and their implementation in routine clinical practice. implant success rate, specific implant characteristics, procedural complications, electrical parameters and clinical outcomes will be analyzed at implantation, 1-3 months after inclusion and every 6 months thereafter. minimal follow-up will be 2 years.

Eligibility criteria:
inclusion criteria: * class i and ii indications for permanent pacing * atrial fibrillation with uncontrolled ventricular rate for pace and ablate strategy * bundle branch block correction for hf patients * patients with prolonged pr interval and dromotropathy

Keywords: his bundle pacing left bundle branch area pacing bachmann bundle pacing
sleep hygiene, sarcopenia, and cognitive function in respiratory disease

Conditions: Sleep Hygiene; Sarcopenia; Cognitive Function; COPD; IPF

Summary: we aim to clarify the relationship between sleep hygiene and the onset of sarcopenia or cognitive dysfunction using sleep time, arousal, and sleep quality as indicators in copd or ipf patients, and clarify the effects of sleep hygiene on disease progression and life prognosis.

chronic obstructive pulmonary disease (copd) and idiopathic pulmonary fibrosis (ipf) have been reported to be associated with a high rate of sleep-related disorders such as insomnia, sleep-related hypoventilation, and sleep apnea syndrome.sleep-related disorders cause symptoms such as daytime sleepiness, decreased adl, and depression, which causes cognitive dysfunction. both copd and ipf have been reported to be associated with cognitive dysfunction. recently, it has been focused on the relationship between sleep-related disorders and sarcopenia. the relationship between sleep hygiene, cognitive dysfunction, and sarcopenia in the patients with copd or ipf is not well understood.

Eligibility criteria:
inclusion criteria: * subjects with copd or ipf. exclusion criteria: * subjects who have been hospitalized for exacerbation of respiratory failure within 1 month of study participation * subjects who have already been diagnosed with sarcopenia or cognitive dysfunction * subjects receiving long-term oxygen therapy (ltot) or non-invasive ventilation therapy (niv) * subjects with obstructive sleep apnea who are indicated for continuous positive airway pressure (cpap) * subjects with severe complications such as cardiovascular disease, liver disease, renal disease, malignancy, and neurological disease.
rehasleep register - prevalence of sleep apnea in cardiac rehabilitation

Conditions: Sleep Apnea

Summary: prevalence of sleep-related breath disturbance in patients in cardiac rehabilitation. the aim of the register is to enable a better diagnosis and early treatment initiation in the context of secondary prevention. in addition to the prevalence, the further course of the patients shall be documented after hospital discharge to verify any gaps (sleep laboratory, therapy introduction) and emphasize the importance of rehabilitation and to examine the possibility of initiating therapy in rehabilitation.


Eligibility criteria:
inclusion criteria: * terminal cardiac treatment in cardiac rehabilitation facility * for example: myocardial infarction, bypass surgery, stent implantation, valve replacement, icd, crt, pacemakers, heart failure exclusion criteria: * no informed consent form signed * limited consent capacity (dementia, addiction, psychosis) * pregnancy

Keywords: cardiological treatment sleep apnea
prognostic value of neonatal markers for the development of neurosensorial sequelae in children infected by cytomegalovirus in utero

Conditions: Congenital Cytomegalovirus Infection

Summary: the main objective of this study is to validate , in the neonatal period, a prognostic score for the development of neurosensorineural sequelae at 1 year and at 2 years in neonates infected in utero by cytomegalovirus. this score will be based on clinical, imaging and biological criteria . the second objective of the study is to estimate the prevalence of this infection in france and to describe its epidemiology through the screening of 12,000 consecutive neonates.

infection with cytomegalovirus (cmv) is the most frequent cause of congenital neurological handicap of infectious origin in industrialized countries. around 10% of infected neonates have symptoms and more than 50% of those will develop long term neurological sequelae and sensorineural hearing loss. among asymptomatic infected neonates 10 to 15% will ultimately develop hearing loss. to establish the prognosis of infected neonates remains difficult and the purpose of the study is to better define early prognosis factors the true burden of cmv congenital infection is unknown in france: the prevalence of the infection as well as the description of its epidemiology (proportion of symptomatic and asymptomatic cases, rate of long term sequelae, proportion of cases following primary or secondary maternal infections) are unknown.

Eligibility criteria:
inclusion criteria: main objective: neonate less than 1 month with congenital cmv infection at birth objectified by the detection of cmv in a urine sample, in saliva or blood (fresh or guthrie card) obtained in the first 10 days life * whose parents accept regular monitoring by the paediatrician investigator * for which a medical examination has been made * affiliated with a social security system * and whose mother has given its written consent to the participation of their child to study exclusion criteria: - children participating in an interventional study

Keywords: cytomegalovirus, congenital, handicap