Kornimate/medical-research-clean huggingface dataset:
covid-19 glycemic control study

Conditions: Type 1 Diabetes; Type 2 Diabetes

Summary: diabetes mellitus is a chronic disease characterized by the inability of the body to maintain normoglycemia. treatment of diabetes relies mostly on diabetes self-management, requiring a large investment of time and energy on a daily basis. psychological wellbeing, behavioral patterns and social context play a major role in diabetes self-management and glycemic control. social isolation behavior (self-quarantining) may impact glycemic control by influencing daily routines, therapy adherence, physical activity, and self-measurement and eating behaviors. therefore, a period of nationwide self-quarantine, such as during the lockdown issued during the covid-19 outbreak in the netherlands, may have a large effect on glycemic control in patients with diabetes. in this observational cross sectional study, we aim to assess the impact of long-term self-quarantine on glycemic control, diabetes self-management and distress in patients with type 1 and type 2 diabetes mellitus. a specific subgroup of patients with t1d are those with complicated diabetes who have received a pancreas or islet transplantation and use immunosuppression, having multiple risk factors for severe covid-19. the impact of lockdown strategies on mental and physical health is expectedly even greater in patients at even higher risk for severe covid-19. we therefore additionally investigated differences in behavioral, mental and physical implications of a nationwide lockdown on patients with type 1 diabetes with and without islet or pancreas transplantation. measurements will be performed during the lockdown period. patients will be asked to perform a fingerprick hba1c measurement once, sent back to the lumc by mail. data from continuous or flash glucose monitoring devices will be collected according to standard clinical practice. furthermore, patients will be asked to fill out an online questionnaire once on diabetes self-management behavior, well-being and distress, along with questions about health status, level of education, medication use, employment, social situation and the impact of self-quarantine on daily routines. in this questionnaire, we ask patients to compare certain aspects of their life (e.g. anxiety, stress, weight, physical activity, glycemic control) at the time of the lockdown to before the lockdown. data on demographics, type of diabetes, weight, bmi and hba1c prior to the covid-19 outbreak will be derived from the patient's electronic health file.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * diagnosed with type 1 or type 2 diabetes * ability to perform fingerpricks * sufficient comprehension of the dutch language * ability to fill out online questionnaires exclusion criteria: * pregnancy * newly diagnosed malignancy, with the exclusion of non-melanoma skin cancer, in the previous 6 months * chemotherapy or immunotherapy for malignancy * admission to hospital or rehabilitation center

Keywords: covid-19 pandemic type 1 diabetes type 2 diabetes beta cell transplantation social isolation glycemic control distress covid-19 lockdown
the impact of different anticoagulant therapy on hemorrhage and coagulation after thoracic surgery

Conditions: Lung Neoplasms; Esophageal Neoplasms; Venous Thromboembolism

Summary: the purpose of this study is to determine whether the use of different dose of lmwh compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of esophageal carcinoma and planned for esophagectomy * clinical diagnosis of lung carcinoma and planned for lung resection * general anesthesia combined with epidural anesthesia exclusion criteria: * blood clotting disfunction before surgery * anticoagulating or antiplatelet history before surgery * low blood platelets count * hemorrhagic disease * cerebral hemorrhage * cerebral,spinal,ophthalmologic operation history * peptic ulcer * bleeding\>400ml in operation * bleeding\>100ml/h after operation * blood transfusion in or after operation * severe renal or liver disfunction * severe hypertension

Keywords: esophagectomy lung resection venous thromboembolism low molecular weight heparin chest drainage teg
efficacy and safety of linagliptin in elderly patients with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the objective of the current study is to investigate the efficacy, safety and tolerability of linagliptin (5 mg / once daily) compared to placebo given for 24 weeks as add-on therapy to stable treatment in elderly patients with t2dm with insufficient glycaemic control


Eligibility criteria:
inclusion criteria: 1. type 2 diabetes mellitus 2. hba1c \>= 7.0% 3. age \>= 70 years 4. signed and dated written informed consent exclusion criteria: 1. myocardial infarction, stroke or tia within 3 months prior to informed consent 2. impaired hepatic function 3. treatment with glitazones, glp-1 analogues, dpp-4 inhibitors or rapid acting or pre-mixed insulins 4. treatment with anti-obesity drugs
observatory of unintentional births hospital extras

Conditions: Unexpected Delivery Outside Maternity

Summary: in france, pre-hospital unexpected birth is a rare situation, but over the last ten years, the investigators have seen an increase in the number of these. for this, the investigators realize an observatory of these deliveries and their care from the call for help and the investigators continue the follow-up and the future of patients and newborns until j7 postpartum.

as a result, the investigators also found a very high variability in the number of deliveries per month for the ems 34 and the sssm of the sdis 34, which can reach up to 11 deliveries per month (may 2014 example). formalized expert recommendations were published in 2010 by sfar, which then led to the establishment of a national observatory for iea at the end of 2011, in which the investigators have been participating for 4 years. currently the national database lists 2000 unannounced deliveries including 230 in the hérault. this observational study allows us to evaluate the management of these patients and newborns, the risks and needs of pre-hospital teams, including the need for reinforcement and expertise of midwives. the investigators can also assess mortality and morbidity, as well as the extension of hospital stays beyond j7

Eligibility criteria:
inclusion criteria: * unexpected delivery outside maternity, presence of a medical team during the care exclusion criteria: * absence of medicalization

Keywords: obstetrics pre-hospital emergencies unannounced delivery outside maternity, mortality-morbidity reinforcement midwife in pre-hospital
a study of ct-388 in otherwise healthy overweight and obese adults and patients with type 2 diabetes mellitus

Conditions: Diabetes

Summary: this is a first-in-human evaluation of ct-388 in a double blind, placebo controlled, randomized, sad/mad/md, safety, tolerance, pk, and pd study when administered as a sc injection in otherwise healthy overweight and obese adult participants and obese participants with t2dm.


Eligibility criteria:
inclusion criteria: * males or females * 18-65 years old, inclusive * bmi 27.0-40.0, inclusive * stable body weight for 2 months exclusion criteria: * significant medical history * uncontrolled hypertension * history of malignancy
recovery of exertion ability following covid-19 infection in military staff

Conditions: SARS-CoV Infection

Summary: the paris fire brigade staff have been particularly exposed to covid-19 due to rescue and care activities for victims at risk in paris area (where the virus was actively circulating). in addition, when the pandemic began in france, they had to take care of patients before procedures to protect caregivers were implemented. the contamination of young military personnel, whose physical capacity was put into strain at work, raises the question of the consequences of covid-19 on their physical fitness. at the time, the medium- and long-term evolution of this disease and its possible repercussions on physical fitness are unknown. moreover, like any soldiers who have been confined, they may present at least a cardio-respiratory deconditioning (sometimes independent of the disease making it difficult to distinguish between a sequelae of the infection or rehabilitation). based on previous coronavirus epidemics (sars-cov 1 and mers-cov), it appears that long-term sequelae are possible even in mild forms and can result in an alteration of exertion ability. in the current context and in the absence of national or international recommendations on the return to physical activity, the french armed forces health service has proposed a simple management plan aiming at: i) allowing mass screening for possible exercise intolerance and targeting at-risk personnel, ii) allowing individualized re-training and iii) guaranteeing that military personnel can carry out their mission without jeopardizing their health.


Eligibility criteria:
inclusion criteria: * be an active military personnel of the paris fire brigade * be at least 18 years of age * benefiting or having benefited from the post-covid medical care provided by the french armed forces health service exclusion criteria: * be under 18 years of age

Keywords: physical activity
characterization of phenotypes of occupational asthma

Conditions: Occupational Asthma

Summary: the general objective of this multicenter, international study is to perform a multivariate descriptive analysis of a large population of well-defined subjects with sensitizer-induced oa ascertained by a positive sic result in order to provide more information on the characteristics of this condition.


Eligibility criteria:
inclusion criteria: * adult patient * patient who performed a specific inhalation test with a positive result between january 2006 and december 2015.- subject giving their consent for their participation * patient agreeing to use his data for research purposes exclusion criteria: * patient objecting to the use of his data for research purposes * subjects under safeguard of justice * subject under guardianship or curatorship

Keywords: asthma occupational asthma
study to investigate the effect of deferasirox on the pharmacokinetics of midazolam

Conditions: Healthy

Summary: this is a study to investigate the pharmacokinetics of deferasirox


Eligibility criteria:
inclusion criteria: * good health * no evidence of iron deficiency * weight between 50 and 100 kg * body mass index between 19 and 29 kg/m2 exclusion criteria: * use of certain drugs, herbal remedies or nutrients other protocol-defined inclusion/exclusion criteria may apply

Keywords: interaction healthy volunteers deferasirox midazolam
turkish version of the postoperative qor-15

Conditions: Surgery; Cross-Cultural Comparison; Postoperative Period; Recovery of Function

Summary: patient perceived quality of recovery is an important outcome after surgery and should be measured in clinical trials. the qor-15 was designed to measure quality of recovery after surgery. it provided an efficient evaluation of the postoperative quality of recovery. the primary objectives of this study is to translate the original qor-15 questionnaire into turkish, and do a full psychometric evaluation of the turkish version. we will test its validity, reliability, responsiveness, and clinical acceptability and feasibility, with patients undergoing abdominal, thoracic, orthopedic, gynecological, urologic, eye and ent surgery, in the university of health sciences, gülhane education and rraining hospital ankara, türkiye.


Eligibility criteria:
inclusion criteria: * aged \> 18 years old * underwent selective or day surgery with general anesthesia (including all surgical categories except heart and vascular surgery) * able to complete the qor-15t in turkish * agreed to provide written informed consent to participate exclusion criteria: * aged \< 18 years old * patients with a neuropsychiatric disturbance * not agreed to provide written informed consent to participate

Keywords: questionnaire quality-of-recovery 15 (qor-15)
diamante - diseases infectious analysis microflora antibiotic effect

Conditions: Gastrointestinal Diseases

Summary: to assess the effects of bacillus clausii (enterogermina®) on fecal microbial flora (using polymerase chain reaction - denaturing gradient gel electrophoresis - pcr-dgge - method) in antibiotic-treated children with complicated acute otitis media or beta-hemolytic streptococcal pharyngo-tonsillitis.


Eligibility criteria:
inclusion criteria: * subjects with persistency of symptoms and requiring antibiotics for bacterial upper respiratory tract infections, i.e. complicated acute otitis media (diagnosed by otoscopic examination) or beta-haemolytic streptococcal pharyngo-tonsillitis (diagnosed by pharyngeal swab and rapid antigen detection test or positive culture); * outpatients or patients attending an emergency room for both diagnoses, and inpatients in case of complicated acute otitis media; * written informed consent from both parents. exclusion criteria: * history of clinically significant chronic diseases, or chronic diseases necessitating the use of continuous drug therapies, or of any disease that may interfere with the successful completion or the objectives of the trial; * clinical evidence of relevant cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, neurological or of any disease that may interfere with the successful completion or the objectives of the trial; * use of antibiotics, prebiotics or probiotics (medications or dietetic supplements) in the last 2 weeks prior to study entry; * hypersensitivity to the investigational product; * subjects enrolled in another trial in the previous three months. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
efficacy of strength training in improving elbow range of motion and function in adults with hemophilia

Conditions: Hemophilia; Elbow Joint Contracture

Summary: this is a research study of adults with hemophilia that have limitations in elbow joint motion that is the result of bleeding into the joint. people with hemophilia who have bleeding into their elbow joint may have limitations in elbow joint movement and pain in the joint. this research is being done to determine the effect a strength training program has on the amount of movement people with hemophilia and elbow joint disease have.


Eligibility criteria:
inclusion criteria: * patients of the oregon health and science university hemophilia treatment center * greater or equal to 18 years old * loss of elbow range of motion that is greater than or equal to 5 degrees exclusion criteria: * present inhibitor
surveillance and tracking the outcomes of chronic latent ebv infection

Conditions: EBV Infection

Summary: immunocompetent subjects with high load of epstein-barr virus dna (ebv-dna) in peripheral blood will be enrolled and prospectively followed up to track the natural histories of the chronic high load of ebv virus. the primary goal of this study is to explore the association of peripheral high load of ebv with the hematological malignancies, and second goal is to investigate the genetic mechanisms of immune escape and tumorigenesis of chronic ebv infection.

epstein-barr virus (ebv) is an oncogenic virus implicated in the pathogenesis of a variety of human hematological malignancies such as lymphomas, hemophagocytic lymphohistiocytosis and chronic active ebv disease. while chronic latent ebv infection（especially carriers with persistent high load of ebv-dna copy number）is the gray zone between the primary infection and the hematological malignancies, which is rarely concerned. previous work has prompted the heterogeneities of ebv infection, such as racial heterogeneity, viral load heterogeneity and heterogeneity of infected target cells. it is of great significance to prospectively track the transforming process and elucidate the association of chronic ebv infection and hemophagocytic lymphohistiocytosis. healthy subjects who was found to have high ebv-dna load （\>1×103 copies/ml）in peripheral blood during the physical examination were enrolled and followed up by telephone or face-to-face interview periodically. the primary outcome is hematological malignancies including burkitt lymphoma, ebv+ b-cell lymphoproliferative diseases, extranodal nk/t-cell lymphoma of nasal type (enkl), aggressive nk-cell leukemia (ankl), classic hodgkin lymphoma,ebv-associated hemophagocytic lymphohistiocytosis and chronic active epstein-barr virus infection (caebv). the exploratory purpose of this study is to investigate of genetic mechanisms of immune escape and tumorigenesis of ebv infection. subgroup analysis will performed in subjects with mild high load (\>1×103 copies/ml and \ 1×104 copies/ml) of ebv-dna copies.

Eligibility criteria:
inclusion criteria: 1. immunocompetent subjects who was found to have high ebv-dna load （\>1×103 copies/ml）in peripheral blood during the physical examination 2. willing to be followed up by telephone or face-to-face interview exclusion criteria: 1. subjects with defined immunodeficiency 2. subjects who have taken or are going to take immunosuppressive drugs. 3. subjects diagnosed a validated hematopathy 4. subjects diagnosis as precancerous lesion or malignant tumor and the life expectancy is less than 1 year. 5. psychological illness which does not allow subjects to understand the study and participate following his own free will 6. pregnant woman 7. no written informed consent

Keywords: chronic ebv infection, hemophagocytic lymphohistiocytosis
an investigational drug study to assess weight loss in obese and overweight patients (0364-037)(terminated)

Conditions: Obesity

Summary: a 1 year worldwide study in obese and overweight patients to assess the safety and effect on body weight of an investigational weight loss drug.


Eligibility criteria:
inclusion criteria: * male or female, 18 years of age or older, with body mass index (bmi) between 30 kg/m2 and 43 kg/m2, inclusive (bmi between 27 kg/m2 and 43 kg/m2, inclusive, for those with obesity-related comorbidities). obesity-related comorbidities associated with a bmi of 27 kg/m2 or higher include hypertension, dyslipidemia or sleep apnea * stable weight (+/-3 kg) for at least 3 months prior to study start exclusion criteria: * history of diabetes mellitis, major psychiatric disorder, significant cardiovascular disease, stroke, tia, neurological disorder, non-febrile seizures * screening systolic blood pressure \> 160 mm hg or diastolic blood pressure \> 100 mm hg
effect of spirulina on liver fibrosis by transient elastography in beta thalassemic children with hepatitis c

Conditions: Beta Thalassemia Major

Summary: thalassemics can develop liver fibrosis because of iron overload and hepatitis c infection. the latter is the main risk factor for liver fibrosis in transfusion dependent thalassemics. excess liver iron is clearly recognized as a co factor for the development of advanced fibrosis in patients with hepatitis virus c infection. transient elastography (fibroscan) is a reliable non invasive method for diagnosing as liver fibrosis in thalassemic patients regardless of the degree of iron overload. there is evidence that suggests spirulina may help to protect against liver damage, cirrhosis and liver failure in those with chronic liver disease.


Eligibility criteria:
inclusion criteria: * multitransfused beta thalassemic children with and without super added hepatitis c virus (hcv) infection diagnosed by serological detection of hcv antibodies and hcv rna by polymerase chain reaction. exclusion criteria: * liver decompensation child younger than 3 years patients with hepatitis b infection implantable cardiac device failure to obtain transient elastography (fibroscan) results
a pilot study to explore the role of gut flora in crohn's disease

Conditions: Crohn Disease; Crohn Colitis; Crohn's Ileocolitis; Crohn Ileitis; Crohn Disease of Ileum; Crohn's Disease Relapse; Crohn's Gastritis; Crohns Disease Aggravated; Crohn Disease in Remission; Crohn's Jejunitis; Crohn's Duodenitis; Crohn's Disease of Pylorus; Crohn's Esophagitis; Crohn's

Summary: this study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding crohn's disease.

the goal of this research study is to better understand how the genetic information in subject's microbiome correlates to the information provided in surveys and in medical records regarding crohn's disease.

Eligibility criteria:
inclusion criteria: 1. signed informed consent, demonstrating that the patient understands the procedures required for the study and the purpose of the study 2. male or female patients age 12 and older. (interest is given to children 12 and older to compare with mothers). 3. diagnosis of non-fistulating crohn's disease confirmed by at least one of the following 1. colonoscopy 2. capsule endoscopy 3. computerized tomography (ct) scan 4. magnetic resonance imaging (mri) 5. balloon-assisted enteroscopy exclusion criteria: 1. refusal to sign informed consent form 2. presence of fistulating crohn's disease 3. treatment with antibiotics within 2 weeks prior to screening 4. treatment with probiotics within 6 weeks prior to screening. 5. history of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy. 6. postoperative stoma, ostomy, or ileoanal pouch 7. participation in any experimental drug protocol within the past 12 weeks 8. treatment with total parenteral nutrition 9. any clinically significant evidence of disease that could interfere with the subject's ability to enter the trial 10. inability to adequately communicate with the investigator or their respective designee and/or comply with the requirements of the entire study