Kornimate/medical-research-clean huggingface dataset:
patient satisfaction in single implant mandibular complete overdentures retained by cm loc versus ball attachment

Conditions: Edentulous; Dental Implant

Summary: this study was conducted to clarify the effect of two different attachments on patient satisfaction and marginal bone loss. the primary and secondary objectives are to determine patient satisfaction and the marginal bone loss around implant when using cm loc compared to conventional ball attachment. all the patients will receive a single median implant to which the denture will be loaded upon using the two different attachment systems


Eligibility criteria:
inclusion criteria: * completely edentulous male or female patients between the ages of 50 to 69. * no contraindications for implantation. * each patient has to perform both a random blood sugar and glycosylated hemoglobin analysis. patients with a glycosylated hemoglobin test hba1c up to 8% and a normal blood sugar level (79 to 110) or controlled diabetic patients (90-130 fasting according to american association of diabetes) will be included. * sufficient bone width (≥ 6 mm) in the anterior region to place an implant. it could be either normally present or achieved by bone plateauing. this will be confirmed by cone beam computed tomographic (cbct) scans. * residual bone height ranging from 11-20 mm with the lowest vertical height in the midline of the mandible not less than 13 mm (class ii or iii according to mcgarry et al.22this will be confirmed by the cbct. * patients seeking to install a single symphyseal implant and for whom new dentures will be constructed. * patients, who are dissatisfied with the retention and stability of their technically satisfactory dentures. * patients, who already have existing maxillary and mandibular complete dentures, and after examination of the mandibular dentures, it is found that there are technical problems with regard to denture design and/or occlusion; then new maxillary and mandibular dentures will be fabricated * all patients should have adapted to their dentures for at least six weeks before being included in the trial. * patients providing written informed consents to participate in the trial and this will be done before the scheduled date for implant installation. exclusion criteria: * patients with a systemic or local contra-indication for implant placement. * satisfied patients with the retention of their mandibular denture as well as unsatisfied patients with their maxillary denture. * patient with a mandibular denture height less than 6 mm between the base of the denture and the incisal edge of the central incisors (as measured by a caliper) or with 12 mm crown height space as measured by a ruler from the incisal edge till the crest of the ridge. this will be done from a putty index of the diagnostic set up. * incompliant and not cooperative patients. * patients smoking more than 10 cigarettes per day

Keywords: single implant
effect of ppe on children's fear in dental office

Conditions: COVID-19; Infections; COVID-19 Virus Infection

Summary: the aim of the current study is to compare the effect of conventional facial ppe as 1)goggles + surgical masks, and 2)face shields + surgical masks versus 3)half-face and 4)full-face reusable respirators; on preoperative child's fear in the dental office.

each patient meeting the inclusion criteria and assigned to a specific study group will enter the clinic for dental examination. the examining dentist, wearing the selected ppe will communicate with patient and parent, taking personal, previous and current history, and carrying out simple examination not involving the use of sharp instruments, provoking pain or investigations as radiographs. the process should take from three to five minutes. then, the child will be escorted to another room to meet a blinded accessor, where he assesses the child's anxiety using the arabic version of children's fear survey schedule-dental subscale cfss-ds.

Eligibility criteria:
inclusion criteria: * six to ten-year-old patients exclusion criteria: * emergency patients * patients who have systemic, mental or psychological conditions as indicated by their medical history,

Keywords: ppe dentist attire child behavior dental fear
acceptance and commitment therapy for chronic pain in integrated primary care

Conditions: Chronic Pain

Summary: this mixed-methods pilot randomized controlled trial sought to: 1) evaluate implementation of a brief acceptance and commitment therapy treatment for chronic pain delivered by an integrated behavioral health consultant in primary care; and to 2) explore treatment outcomes and their associated mechanisms of change.

background: most patients with chronic pain obtain their treatment in primary care settings, where evidence-based behavioral interventions are not typically provided, despite robust evidence for treatments like acceptance and commitment therapy. objective: this mixed-methods pilot randomized controlled trial sought to: 1) evaluate implementation of a brief acceptance and commitment therapy treatment for chronic pain delivered by an integrated behavioral health consultant in primary care; and to 2) explore treatment outcomes and their associated mechanisms of change. design: mixed-methods pilot randomized controlled trial. active participants completed one 30-minute individual focused acceptance and commitment therapy (fact) visit followed by 3 weekly 60-minute group visits and a booster visit 2 months later. an enhanced treatment as usual (etau) control group received 4 handouts about pain management based on cognitive behavioral science. follow-up research visits occurred during and after treatment, at 12 weeks (booster visit), and at 6 months. semi-structured interviews were conducted after the last research visit. setting: a small integrated primary care clinic in southwestern u.s. affiliated with an academic medical center

Eligibility criteria:
inclusion criteria: * age 18 and older * at least one non-cancer pain condition persisting for 12 weeks or more * a current primary care clinician at the study clinic * ongoing treatment for a non-cancer chronic pain condition exclusion criteria: * social anxiety or unwillingness to participate in a class setting * presence of symptoms of psychosis and/or delirium * a medical condition or life circumstance that would contraindicate or prevent participating (e.g. upcoming surgery) * inability to comprehend the informed consent process or study instructions.

Keywords: chronic pain acceptance and commitment therapy integrated primary care behavioral health consultant
type 2 diabetes and exercise - a pilot study

Conditions: Type 2 Diabetes

Summary: a randomised, cross-over trial targeting a small sample of older (age 45-65 years) overweight adults with type 2 diabetes the aims of this pilot study are to: 1. determine the feasibility of investigating the acute effects of prolonged sedentary behaviour (sitting) in this target group. 2. compare the acute effects of a single prolonged (8 hour) bout of sedentary behaviour (sitting) on glucose and triglyceride concentrations and key muscle and adipose regulatory enzymes to a similar bout of sedentary behaviour combined with intermittent bouts of light-intensity activity.

the proposed study will involve a randomised cross-over experimental trial conducted in the laboratory setting in older overweight adults with type 2 diabetes. participants will receive both of the acute testing conditions in a randomised manner. study design: randomised cross-over pilot trial of 20 overweight/obese older adults with diet-controlled type 2 diabetes involving 2 acute treatment conditions, with a one-week wash-out period between testing conditions (figure 1 a). setting: acute, supervised laboratory setting within the alfred and baker heart institute medical unit. outcomes: we will measure acute responses in laboratory-measured plasma glucose \& triglyceride levels (every 60 mins) and glucose concentrations determined from continuous glucose monitoring (cgms).

Eligibility criteria:
inclusion criteria: 1. diet controlled diabetes 2. overweight (bmi \> 27 kg/m2 but \<50 kg/m2) exclusion criteria: 1. hypoglycaemic agents 2. lipid lowering agents
cognition and imaging with tigertriever

Conditions: Stroke

Summary: the objective of the cognitive study is to evaluate whether successful reperfusion with tigertriever is associated with cognitive benefit.


Eligibility criteria:
inclusion criteria: 1. patients admitted with large vessel occlusion (lvo) and treated with the tigertriever, as indicated per the approved ifu. 2. tigertriever was used as the first line treatment in the target vessel. 3. a signed informed consent. 4. age 18-75 years (inclusive). 5. no known significant pre-stroke disability (pre-stroke mrs 0 or 1). exclusion criteria: 1. use of any other ia recanalization device prior to the tigertriever in the target vessel, including aspiration catheter. 2. evidence of acute brain hemorrhage on ct and/or mri at admission. 3. prior hemorrhage, stroke, thrombolysis, and/or endovascular therapy in the last 3 months. 4. probable cerebral amyloid angiopathy. 5. pre-stroke diagnosed dementia and/or prescribed cholinesterase inhibitors. 6. pre-stroke diagnosed and/or currently treated major depression. 7. pre-stroke learning or intellectual disability. 8. anticipated inability to obtain 6-month follow-up assessments. -
artificial reproductive techniques (art) and progression of endometriosis symptoms

Conditions: Endometriosis

Summary: this project will investigate worsening of symptoms in endometriosis patients undergoing artificial reproductive techniques (art). the study compares patients with peritoneal/ovarian and deep infiltrating endometriosis to relevant reference groups. symptoms are monitored with a questionnaire with the categories quality of life, pain and bowel habits. the ehp-30® questionnaire is included in the questionnaire.

endometriosis affects up to 10% of all fertile women, and is associated with symptoms like infertility, dysmenorrhea, deep dyspareunia and chronic pelvic pain. 10-25% of endometriosis patients need artificial reproductive techniques (art) to become pregnant. endometriosis is estrogen dependent, and in theory this means, that the increased levels of estrogen during fertility treatment will worsen endometriosis symptoms. endometriosis is a benign disease, and treatment is guided by the patient's symptoms. worsening of endometriosis symptoms during fertility treatment may result in cessation of the treatment, operation and risk of complications. this project will investigate worsening of symptoms in endometriosis patients undergoing artificial reproductive techniques (art). the study compares endometriosis patients undergoing art to two relevant reference groups; one group consisting women undergoing art with infertility because of factors other than endometriosis, and one group consisting women with medically treated endometriosis not undergoing art. symptoms of endometriosis during art will be monitored using a questionnaire that among other questions includes the validated questionnaire endometriosis health profile 30® (ehp-30®). the questionnaire is administered before starting art and later in the cycle before the patient gets to know if she is pregnant. the questionnaires as well as data collection will be administered electronically in redcap® which is a secure web application for building and managing online surveys and databases.

Eligibility criteria:
inclusion criteria: * female * \< 40 years * either undergoing art (ivf or icsi) with or without endometriosis or medically treated endometriosis exclusion criteria: * \> 40 years

Keywords: fertilization in vitro sperm injections, intracytoplasmic endometriosis
the effect of gallstone characteristics for the severity of gallstone pancreatitis

Conditions: Acute Gallstone Pancreatitis

Summary: the purpose of this study was to determine the effect of gallstone characteristics for the severity of acute gallstone pancreatitis (gsp)

the timing of cholecystectomy is closely related to the severity of acute gallstone pancreatitis (gsp). the effect of gallstone characteristics (including stone size, number, etc.) for the severity of gsp are currently unknown.

Eligibility criteria:
inclusion criteria: * acute gallstone pancreatitis (gsp) patients. exclusion criteria: * pancreatitis with bile duct stones, trauma, drugs, and surgery; * recurrent gallstone pancreatitis; * combined with other malignant tumors, such as liver cancer, cholangiocarcinoma, pancreatic cancer, gastric cancer, hematologic tumor, and lymphoma; * previous hepatobiliary and pancreatic surgery, organ transplantation; * intestinal obstruction or other obstructive diseases; * chronic pancreatitis or pancreatic duct stones; * thrombotic disease; * alcoholic pancreatitis and hyperlipidemia pancreatitis.

Keywords: pancreatitis gallstone severity
effect of anti-hypertensive medications on the diagnostic accuracy in screening for primary aldosteronism

Conditions: Hypertension; Primary Aldosteronism

Summary: to evaluate the effect of anti-hypertensive medication on efficiency of primary aldosteronism screening test, and to determine the appropriate diagnostic cutoff value for chinese hypertension patients during antihypertensive drugs therapy.

aldosterone-renin ratio (arr)is currently the most reliable means available for screening for primary aldosterone（pa）. however, some antihypertensive drugs may cause false positives and false negatives on arr. thus, america pa guidelines suggest that antihypertensive drugs should be withdraw or change therapy before screening. but withdraw/changing the therapy before arr is inconvenient for patients. the investigators prepare to start a prospective study through recruiting hypertension patients who needs arr screening test, completing the arr screening before and after withdraw/change therapy.

Eligibility criteria:
inclusion criteria: * persistent hypertension \>150/100mmhg, including previously diagnosed grade 2 hypertension but well controlled by 1-2 drugs; newly diagnosed hypertension with 3 days blood pressure \> 150 / 100mmhg * resistant hypertension(combined with three antihypertensive drugs and one of them is diuretic but blood pressure is still greater than 140 / 90 mmhg ; or need to combined four anti-hypertensive drugs to control the blood pressure under 140 / 90 mmhg) * family history of hypertension with early onset (\< 40 years old) * family history of hypertension with early onset (\<40 years old) and cerebrovascular accident * hypertension with spontaneous or diuretic hypokalemia * hypertensive with adrenal incidentaloma * hypertensive with osas * first-degree relatives of pa patients and with hypertension stable antihypertensive medication therapy for more than 2 weeks, medication including：β-blockers, ccb, acei, arb, mra, and other diuretics. exclusion criteria: * patients hard to change or stop the medication for accomplish the screening test or diagnosis unwilling to participate the study and refuse to sign on informed consent patients who was diagnosed with other secondary hypertension suspected with pa（rein concretion beyond the limit of normal reference range after stoping or changing the medication） severe renal insufficiency （egfr\<30 ml/min/1.73m2）; pregnancy

Keywords: hypertension aldosterone-renin ratio primary aldosteronism
motion syros: a study to investigate the efficacy of tradipitant in subjects affected by motion sickness

Conditions: Motion Sickness

Summary: a multi-center, randomized, double-blind, placebo-controlled study to investigate the efficacy of tradipitant in subjects affected by motion sickness during travel


Eligibility criteria:
inclusion criteria: * history of motion sickness * age 18-75 exclusion criteria: * nausea-inducing disorder other than motion sickness * bmi\>40 * history of intolerance and/or hypersensitivity to neurokinin-1 receptor antagonists
effect of linagliptin + metformin on patients who do not achieve normoglucemia with metformine

Conditions: Prediabetic State; Impaired Glucose Tolerance; Insulin Resistance

Summary: the goal of this protocol is to evaluate the effect of addhing linagliptin to patients with prediabetes who do not reverse to normoglycemia after 12 months of treatment with metformin alone. the duration of the study will be 6 months, and it is primarily a efficacy study. main outcomes will be glucose levels during ogtt, insulin secretion and pancreatic beta cell function measured by the disposition index derived from the ogtt.

randomization and masking. patients will be randomly assigned in a 1:1 ratio to receive linagliptin/metformin 2.5/850mg every 12 h + lifestyle modification program, or metformin 850mg every 12 h + lifestyle modification program during 6 months. randomization will be performed using an electronic random numbers table by a nutritionist not involved in the study. participants and investigators involved in the patients follow-up and outcome measurements will be masked to treatment allocation during the entire study. patients will have a follow-up visit every month. every appointment is about 30-45 minutes; medications tolerance and side effects will be recorded in every patients´ visit. nutritional and physical activity assessment according to the patient´s weight will be performed by a nutritionist every month. monthly adherence to medications will be evaluated by pill counting; nutritional adherence and energy intake will be evaluated at 6 months by a food frequency questionnaire, and physical activity at 0 and 6 months. at basal and at 6 months patients will have an ogtt. primary objective is to evaluate at 6 months glucose profile during ogtt, insulin secretion and pancreatic β-cell function by the ogtt di, and regression to normoglycemia; t2d will be diagnosed and confirmed by at least two consecutive measurements of the same criteria: glycated haemoglobin ≥ 6.5 %, fasting glucose ≥ 126mg/dl, or 2 h glucose ≥ 200 mg/dl.

Eligibility criteria:
inclusion criteria: * patients with impaired glucose tolerance (2 h glucose between 140 - 199 mg / dl) that after 1 year of treatment with metformin at a dose of 1700 mg daily + lifestyle modifications don't achieve normoglycemia. * patients who accept to participate in the study and sign informed consent. exclusion criteria: * patients with type 2 diabetes diagnosted previuosly or detected during the ogtt * serum creatinine \> 1.6 mg/dl * hypertriglyceridemia very high (\>500 mg/dl) * pregnancy * systolic blood pressure \> 180 mmhg or diastolic blood pressure \>105 mmhg (patients could be re-screened after blood pressure control) * excessive alcohol intake, acute or chronic * medications or medical conditions that affect glucose homeostasis (thiazides, beta blockers, glucocorticoids for systemic use, weight-reducing drugs or anorexigenics, cushing's syndrom, thyrotoxicosis.

Keywords: prediabetes insulin resistance hyperglucemia
comparison of vagus nerve-preserving radg and conventional radg for agc

Conditions: Gastric Cancer

Summary: through comparative observation of robot vagus nerve preserving distal gastric cancer radical surgery and conventional robot distal gastric cancer radical surgery (not reserved vagus nerve) operative and postoperative indicators, and evaluating the feasibility and safety of vagus nerve preserving distal gastric cancer radical surgery in advanced gastric cancer. which can provide the evidences for the clinical development of the preserving function gastric cancer surgery.

compare the robot vagus nerve preserving distal gastric cancer radical surgery and conventional robot distal gastric cancer radical surgery (not reserved vagus nerve). observe the operative and postoperative indicators, and evaluate the feasibility and safety of vagus nerve preserving distal gastric cancer radical surgery in advanced gastric cancer. which can provide the evidences for the clinical development of the preserving function gastric cancer surgery.

Eligibility criteria:
inclusion criteria: 1. male or female, aged less than 70 years and more than 18 years; 2. underwent gastroscopy and biopsy - preoperative definite for advanced gastric cancer invasion depth is t2, t3; 3. the lesion is in the middle and lower stomach; 4. magix routine upper gastrointestinal barium meal, endoscopic ultrasonography, abdominal ct and chest x ray examination, clearly no nerve invasion and adjacent organ invasion and distant metastasis; 5. the preoperative examination of lung, liver, heart, renal insufficiency, surgical contraindication; 6. the preoperative abdominal ct or abdominal ultrasound without biliary disease and gallbladder stones; 7. no history of gastrointestinal dysfunction and other malignant tumor history; 8. the patients voluntarily participate in the study and signed informed consent. exclusion criteria: 1. older than 70 years old or because of chemotherapy surgery and complications after intolerance; 2. the vagus nerve invasion or invasion of adjacent organs or confirmed the presence of distant metastasis; 3. have a history of abdominal surgery or chemotherapy before surgery; 4. the recent cardiovascular hemorrhagic or ischemic disease; 5. the amount of abnormal glucose tolerance or diabetes; 6. not suitable for robotic surgery, such as body short that mechanical arm can not have enough activity range; 7. the history of biliary calculi or gastrointestinal dysfunction; 8. the other is not suitable for receiving robot surgery; 9. participated in other clinical studies in the last month; 10. other researchers not suitable for participation in the study of (hiv infection and intravenous drug addict), or other effects of this clinical study results analysis of the situation.

Keywords: robotic surgery vagus nerve preserving
using text messages to improve oral chemotherapy for adolescents and young adults with acute lymphoblastic leukemia

Conditions: Acute Lymphoblastic Leukemia

Summary: the purpose of this section is to learn how text message reminders might help with regularly taking chemotherapy medications for adolescents and young adults (aya) with acute lymphoblastic leukemia (all).

this study aims to compare adherence to oral mercaptopurine and methotrexate during the first 84-day cycle of maintenance therapy for adolescent and young adult patients with acute lymphoblastic leukemia on pediatric-based regimens between those who receive the high intensity text message intervention and those who receive standard-of-care. it is believed that high-intensity text messages will increase patient adherence within cycle 1.

Eligibility criteria:
inclusion criteria: * age of 15-39 years-old at the time of initial all diagnosis * diagnosed with all * currently receiving treatment with pediatric-based regimen that includes maintenance with mercaptopurine and methotrexate (e.g., calgb 10403). study participation begins with the start of maintenance, so enrollment occurs prior to the start of maintenance. exclusion criteria: * patient or caregiver who would receive text message reminders does not have a cell phone that receives text messages * patient does not wish to participate

Keywords: oral chemotherapy