Kornimate/medical-research-clean huggingface dataset:
comparison of valsartan with amlodipine in hypertensive patients with glucose intolerance

Conditions: Hypertension; Type 2 Diabetes Mellitus

Summary: various guidelines recommended angiotensin converting enzyme (ace) inhibitors or angiotensin ⅱ receptor-1 blockers (arbs) for hypertensive patients with diabetes on the basis of the cardiac- and reno-protective effects of these drugs. however, these recommendations could not be extrapolated to japanese patients, because japan has been known as a country with a low incidence of coronary artery disease and a high incidence of cerebrovascular disease. furthermore, calcium channel blockers (ccbs) also were protective against renal function as well as ace inhibitors in japanese diabetic hypertensive patients. this study will test whether arbs or ccbs are superior in treating japanese diabetic hypertensive patients.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of hypertension * clinical diagnosis of type 2 diabetes or impaired glucose tolerance exclusion criteria: * history of congestive heart failure, myocardial infarction, or coronary revascularization in the recent 6 months. * taking calcium channel blocker for the purpose of angina pectoris * reduced ejection fraction (\< 40%) * second- or third-degree of atrioventricular block * severe hypertension (\> 200/110 mmhg) or secondary hypertension * history of stroke in the recent 6 months * serum creatinine \> 2.5 mg/dl * estimated survival duration less than 3 years due to other conditions * pregnant woman or possibly pregnant woman

Keywords: cardiovascular disease rennin-angiotensin system calcium channel blocker impaired glucose tolerance
effects of photobiomodulation (pbm) on pain after presentation of aphthous ulcers in pediatric dental patients

Conditions: Aphthous Ulcer

Summary: the purpose of this study is to compare the efficacy of laser photobiomodulation and "magic mouthwash" for treatment of pain in pediatric patients with aphthous ulcers , to assess how photobiomodulation influences the rate of healing of aphthous ulcers in pediatric patients and to measure changes in pain levels reported by pediatric patients undergoing photobiomodulation treatment for aphthous ulcers.


Eligibility criteria:
inclusion criteria: * patient/guardian speaks either english or spanish * patient presenting with one or more aphthous ulcers in their mouth, identified during a scheduled dental appointment * no previous pbm treatment to the presenting aphthous ulcer(s) * guardian able to partake in a follow-up phone call in either the english or spanish language exclusion criteria: * patient presents with aphthous ulcers recently treated with pbm * patient presents with herpes labialis (cold sores) * patients presents with systemic disease that affects soft tissue/mucous healing

Keywords: magic mouthwash laser treatment
gonal-f consort (consistency in r-hfsh starting doses for individualised treatment)

Conditions: Infertility

Summary: this non-interventional study (nis) is planned to examine the consistency of the dose recommended by the doctor for the first stimulation day with the dose recommended by the consort calculator.

since the introduction of the first recombinant human follicle stimulating hormone (fsh) preparation gonal-f in the year 1996, a pure drug is available as raw material, which is independent of human urine due to biotechnological methods and consequently can be produced free of contaminating proteins. in accordance with the recommendations of european medicines agency (emea) in february 1999, on the basis of data from clinical studies, gonal-f should be regarded as the more effective preparation in comparison to urinary fsh. serono has developed a dose calculator, the consort calculator, after analyzing the data from clinical studies for gonal-f. this non-interventional study is planned to examine the consistency of the dose recommended by the doctor for the first stimulation day with the dose recommended by the consort calculator. all subjects, who undergo stimulation with gonal-f in preparation for a technology of the assisted conception in accordance with the permitted indication, will be included in this non-interventional study. objectives primary objective: * to examine, how far the dose recommended by the doctor for the first stimulation day varies from the dose recommended by the consort calculator

Eligibility criteria:
inclusion criteria: * female subjects undergoing stimulation with gonal-f in art in accordance with the permitted indication * subjects below 35 years of age * subjects who have a body mass index below 30 * subjects with a basal fsh below 12 i.e./l and is downregulated in the long gonadotropin hormone releasing hormone agonist (gnrha) protocol

Keywords: infertility reproductive technologies, assisted r-hfsh gonal-f
greater occipital nerve pulsed radiofrequency in cervicogenic headache

Conditions: Headache, Cervicogenic; Cervicogenic Headache

Summary: the effect of gon prf treatment applied with usg-guided proximal technique in patients who do not respond to conservative treatments for cervicogenic headache

in our study, gon prf will be applied to volunteers who are diagnosed with cervicogenic headache according to ichd-3 criteria, who meet the study criteria and who report a positive effect with diagnostic gon block application. the main purpose of our study is to evaluate the clinical efficacy and safety of ultrasound-guided c2 level greater occipital nerve pulsed radiofrequency treatment in cervicogenic headache during the follow-up period. our secondary purpose is to determine the effects of the gon prf treatment we applied on the volunteers' analgesic drug consumption, daily life activities and sleep, how they generally perceive this treatment and whether there is a need for any additional treatment.

Eligibility criteria:
inclusion criteria: * diagnosed with cervicogenic headache according to ichd-3 criteria * cranial and cervical spine imaging is available * number of headache days per month 5 and/or more * inadequate benefit from pharmacological treatments or physical therapy methods used * volunteer patients who can understand and approve the treatment and the informed consent form and who can comply with the treatment exclusion criteria: * history of secondary headache other than cervicogenic headache according to ichd-3 criteria * cervical nerve root irritation and/or spinal stenosis symptoms and signs * sensory deficit findings in the greater occipital nerve dermatome * craniocervical defect or other anatomical abnormality in the target area or nearby the procedure * local or systemic infection * received nonpharmacological treatment within the last 3 months (physical therapy, botulinum toxin a, acupuncture, ozone, cognitive behavioral therapy, etc.) * pregnancy or suspected pregnancy * known allergy to local anesthetic drugs * history of malignancy * known organic disease of the brain and spinal cord * history of cranial/cervical surgery within the last 1 year * bleeding-clotting disorder or oral anticoagulant use * comorbid disease that may cause headache (uncontrolled hypertension, intracranial lesion, etc.) * compliance with treatment and treatment results diseases that may affect the evaluation (psychiatric disorder, dementia, etc.) * those who request re-treatment due to the emergence of contralateral pain or other types of pain during the follow-up period after treatment * those who do not accept treatment

Keywords: cervicogenic headache, proximal gon prf, ultrasound guided, c2 level
a post-marketing safety study of gsk bio ipv vaccine (poliorixtm) in korean children

Conditions: Poliomyelitis

Summary: following licensing of poliorixtm in korea, this study will collect safety data about the routine use of this vaccine in 600 children according to the regulations of korean food and drugs administration (kfda).

an open, multicentric, post-marketing surveillance study to monitor the safety and reactogenicity of glaxosmithkline biologicals. poliomyelitis vaccine (inactivated) -poliorixtm., administered in korean children as a primary vaccination in healthy subjects aged two to six months or as a booster vaccination in subjects aged four to six years.

Eligibility criteria:
inclusion criteria: * a healthy male or female child between two and six months of age (primary vaccination) or between four and six years of age (booster vaccination) at the time of vaccination. * subjects for whom the investigator believes that their parents/guardians can and will comply with the requirements of the protocol (e.g. completion of the diary cards) * written informed consent obtained from the parent/ guardian of the subject exclusion criteria: * at the time of study entry, the contraindications and precautions of use indicated in the korean label should be checked and the subject must not be included in the study if there is any contraindication or risk
tissue culture versus swab culture in prosthetic joint infections

Conditions: Revision Total Hip Arthroplasty; Revision Total Knee Arthroplasty

Summary: the main purpose of this study is to compare the effectiveness and accuracy of tissue cultures and swab cultures to diagnose prosthetic joint infection.


Eligibility criteria:
inclusion criteria: 1. patients are scheduled for revision tja surgery. 2. subjects are willing to sign the informed consent document. exclusion criteria: 1. subject not willing to sign the informed consent document.
surgical treatment of early stage glotto-supraglottic laryngeal cancer via transoral resection with robotic assistance

Conditions: Laryngeal Neoplasms

Summary: the main objective of this study is to determine the rate of healthy surgical margins after tumor resection in transoral robot-assisted surgery for glottic and/or supraglottic early stage (t1-t2) laryngeal cancer.


Eligibility criteria:
inclusion criteria: * the subject has signed consent * the subject must be a member or beneficiary of a health insurance plan * the patient is available for 12 months of follow-up * the subject has a cancer of the larynx: * classified t1 or t2 in the tnm * glottic localization and / or supraglottic regardless of node status * with or without a history of head and neck cancer * the subject does not have distant metastasis (m0) * a decision for endoscopic robot-assisted surgery is retained in multidisciplinary meeting exclusion criteria: -

Keywords: da vinci surgical robot laryngeal cancer
effects of power mobility on young children with severe motor impairments

Conditions: Cerebral Palsy; Arthrogryposis; Spinal Muscular Atrophy; Other Central Nervous System or Musculoskeletal Disorders

Summary: the purpose this study is to determine the effects of power mobility on the development and function of young children of young children whose severe physical disabilities limit their exploratory behaviors and may unnecessarily restrict their cognitive, communication, and social-emotional development.


Eligibility criteria:
inclusion criteria: * must be between 14- and 30-months of age * must have clinical diagnosis of a motor impairment that prevents functional independent mobility * must have adequate vision and hearing to use power mobility device safely * must have cognitive abilities equivalent to a 12-month level or alertness and interest in the environment that suggests a trial of power mobility is warranted

Keywords: power wheelchairs power mobility young children
study evaluating intepirdine (rvt-101) in subjects with dementia with lewy bodies: the headway-dlb study

Conditions: Dementia With Lewy Bodies

Summary: this study seeks to evaluate the efficacy and safety of intepirdine (rvt-101) in patients with dementia with lewy bodies.

the efficacy and safety of rvt-101 at doses of 70 mg and 35 mg daily will be evaluated over a 24-week double-blind treatment period in patients with dementia with lewy bodies. the randomization ratio will be 1:1:1 (70 mg rvt-101: 35 mg rvt-101: placebo). subjects completing this study will be eligible to enroll in an extension study of rvt-101 (study rvt-101-2002).

Eligibility criteria:
inclusion criteria: * male or female subject with probable dlb * mini mental state examination (mmse) score of 14-26 inclusive at screening and baseline * patient has the ability to comply with procedures for cognitive and other testing in the opinion of the investigator * patient has a reliable caregiver who is willing to report on the subject's status throughout the study * patients currently receiving therapy for dlb are eligible for enrollment exclusion criteria: * atypical clinical features or clinical course that would lead the investigator to conclude primary symptoms are more likely explained by an alternate dementia diagnosis. * any clinically relevant concomitant disease that, in the opinion of the investigator, makes the patient unsuitable for inclusion in the study.

Keywords: dementia with lewy bodies lewy bodies intepirdine rvt-101 dementia
assessing the impact of two methods of continuous veno-venous hemodiafiltration on time nursing work in intensive care

Conditions: Acute Renal Failure

Summary: the prevalence of acute renal failure in intensive care is estimated at between 5 and 20% depending on diagnostic criteria retained. and half of patients require the use of hemodialysis. continuous veno-venous hemodiafiltration (cvvhdf) is one of the hemodialysis technique widely used in intensive care unit. the cvvhdf is performed at the bedside, by a mobile generator with a semi permeable membrane, a blood circuit, a dialysate circuit and a feedback circuit. the implementation of a cvvhdf requires the use of large amounts of biological liquid essential to enable the purification of blood during its passage through the artificial kidney. the objective of this study is to assess time nursing work and the costs of each method.

the prevalence of acute renal failure in intensive care is estimated at between 5 and 20% depending on diagnostic criteria retained. and half of patients require the use of hemodialysis. continuous veno-venous hemodiafiltration (cvvhdf) is one of the hemodialysis technique widely used in intensive care unit. the cvvhdf is performed at the bedside, by a mobile generator with a semi permeable membrane, a blood circuit, a dialysate circuit and a feedback circuit. the implementation of a cvvhdf requires the use of large amounts of biological liquid essential to enable the purification of blood during its passage through the artificial kidney. the biological fluid may be supplied to the generator of cvvhdf in 2 ways: * the conventional method, the most used: the generator operates with pockets containing dialysis fluid, these pockets to be changed regularly by nurses * the on-line method: the generator operates with a specific water system supplying the dialysis fluid available in every room of the unit the objective of this study is to assess time nursing work and the costs of each method. for this, 15 patients will be included in this study. each patient performs 12 hours of each method (conventional and online), whose order will be randomized.

Eligibility criteria:
inclusion criteria: * patient affiliated with or beneficiary of a social security category * patient with a renal failure requiring a cvvhdf for at least 2 cycles of 12 hours exclusion criteria: * n/a

Keywords: hemodiafiltration cost dialysis solution acute renal failure intensive care unit
mobile education for emergency ultrasound

Conditions: Educational Problems

Summary: the investigators aim to investigate the feasibility of using mobile application platform for sonographic education. junior physicians at the national taiwan university hospital will be enrolled in this study. to design and develop a secure mobile application platform (consisting of mobile device and a cloud-based server) for interactive teaching, remote social-based consultation and discussion. the information exchange through the platform carries images and simulated cases. this pioneer study can provide experience of mobile sonographic education and contribute to current medical education. moreover, it can improve decision-making process and quality of care, and could lessen crowdedness at emergency departments. furthermore, the integrated platform can be used in other educational programs in the future.

as usual, it takes time for junior emergency physicians to have good diagnostic accuracy through traditional sonographic education. applying the technology built in this project, junior emergency physicians will be provided with intelligent learning programs anywhere and anytime. junior physicians at the national taiwan university hospital will be enrolled in this study.

Eligibility criteria:
inclusion criteria: the junior physicians of the department of emergency medicine of the national taiwan university hospital. exclusion criteria: the junior physicians of the department of emergency medicine of the national taiwan university hospital, refused to enter the study.

Keywords: emergency medicine ,emergency ultrasound
determinants of health status and quality of life in patients with primary immunodeficiencies inhereted diagnosed during childhood

Conditions: Primary Immune Deficiency

Summary: background: most children with primary immune deficiency (pid) now reach adulthood. however, few studies have evaluated their health status and health related quality of life (hrqol). objective: to investigate long-term morbidity, the french reference center for pids initiated a prospective multicenter cohort: the f-cilc (french childhood immune deficiency long-term cohort). the data collected will be used to assess the physical health condition of patients who reached adulthood and the impact on their quality of life. methods: patients are asked to complete health status questionnaires. a severity score (grade1 \["mild"\] to grade 4 \["life-threatening"\]) is assigned to each health condition. the hrqol of patients is compared to age- and sex-matched french normal values using the sf36 hrqol questionnaire. capsule summary. this will be the first study of adult survivors of childhood pid describing how the burden of health conditions affect their quality of life.


Eligibility criteria:
inclusion criteria: * patient with primary immune deficiency diagnosed during childhood exclusion criteria: * patients not willing to answer to quality of life questionnaires
effects of vitamin d and omega-3 on cerebrovascular disease

Conditions: Stroke; Vitamin D

Summary: the vitamin d and omega-3 trial (vital; nct 01169259) is a completed randomized clinical trial in 25,875 u.s. men and women which investigated whether taking daily dietary supplements of vitamin d3 (2000 iu) or omega-3 fatty acids (omacor® fish oil, 1 gram) reduced the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. observational follow-up of participants is currently ongoing. the current study is being conducted among participants in vital who experience a stroke event during follow-up and will examine whether vitamin d or omega-3 fatty acid supplementation impact post-stroke outcomes.

stroke is a leading cause of disability and death worldwide and is expected to become an even more prevalent cause of disability in the future as the population ages. understanding risk factors which may prospectively influence stroke outcomes may help to reduce the morbidity burden of stroke. the vitamin d and omega-3 trial (vital) examined the impact of vitamin d3 (2,000 iu/day cholecalciferol) and omega-3 fatty acids (840 mg eicosapentaenoic acid \[epa\] + docosahexaenoic acid \[dha\]) on stroke incidence. however, the parent trial did not examine the impact of these supplements on stroke outcomes. even if they do not significantly reduce stroke incidence, these supplements may still reduce stroke severity and improve outcomes post-stroke. given the high morbidity burden of stroke, the impact of these supplements on stroke outcomes is of substantial scientific and public health importance. the first aim of this study is to test whether vitamin d3 or omega-3 fatty acid supplementation reduces the risk of poor functional outcomes as measured at hospital discharge and 6- and 12-months post-stroke. the second aim is to determine whether chronic cerebrovascular changes (white matter hyperintensity volume and cerebral microbleeds) mediate the effect of vitamin d3 or omega-3 fatty acid supplementation on stroke outcomes. individuals enrolled in vital who experience a non-fatal stroke event will be mailed additional questionnaires assessing functional limitations, physical disability, and social disability. responses from these questionnaires will be used to determine the effect of vitamin d3 or omega-3 fatty acid supplementation on post-stroke outcomes.

Eligibility criteria:
inclusion criteria: * participants eligible and willing to participate in the main vital trial (nct 01169259) who experience a stroke during follow-up. exclusion criteria: * participants eligible and willing to participate in the main vital trial (nct 01169259) who do not experience a stroke during follow-up.

Keywords: stroke stroke outcomes vitamin d omega-3 fatty acid
hyperglycemia and acute pancreatitis

Conditions: Acute Pancreatitis (AP); Diabetes Mellitus

Summary: the goal of this observational study is to learn about post-acute pancreatitis diabetes mellitus (ppdm-a). the main questions it aims to answer are: 1. what are the clinical characteristics of ppdm-a? 2. what are the related factors for ppdm-a? all patients with acute pancreatitis have been given standardized treatment for the condition. the researchers will compare the ppdm-a group with the non-ppdm-a group to find the risk factors for ppdm-a.

investigators retrospectively collected data from patients with acute pancreatitis (ap) in participating centers between january 2013 and june 2024.

Eligibility criteria:
inclusion criteria: 1. patients with pancreatitis attending participating centers since january 2013 (patients with clinically reported ap (icd-10:k85 or related diagnosis)); 2. age between 18 and 80 years; 3. patients have undergone glucose metabolic tests at least 1 month after discharge from hospital. exclusion criteria: 1. patients with a history of diabetes mellitus prior to the ap attack; 2. patients who underwent pancreatic surgery; 3. patients with hereditary pancreatitis and autoimmune pancreatitis; 4. patients with missing data regarding age or gender.

Keywords: acute pancreatitis diabetes mellitus ppdm-a risk factor