Kornimate/medical-research-clean huggingface dataset:
the influence of helping relationships from significant others on healthy lifestyle and quality of life among patients with chronic kidney disease: a longitudinal study

Conditions: Chronic Kidney Diseases

Summary: helping relationships from significant others may assist patients with chronic kidney diseases to exercise health behaviors. patients will adhere on the suggestions from medical staff and perform health lifestyle to maintain healthy behavior. the progress of the disease may be delayed. the research is a 3-year study to explore the influence of helping relationships on healthy behaviors among patients with chronic kidney disease. building on the findings from the past three years study and the literature on trans-theoretical model, helping relationships will be articulated. a helping relation intervention will be applied to evaluate its effect on healthy lifestyle and quality of life. the first year study will be a survey design. an instrument to measure the helping relationship will be established and tested. total of 200 participants will be recruited to test the reliability and validity of the instrument. after evaluating the psychometric properties of the instrument, items may be revised according to the results. the second year of research will be a cross-section study. of 250 subjects will be recruited to explore the correlations between helping relationships, healthy life styles, and quality of life. data will be analyzed using hierarchical linear regression. in the third year, an experimental design will be applied to test the effect of a helping relationship intervention. one hundred and twenty subjects will be recruited and randomly assigned to the experimental and the control group for 60 subjects in each group. the helping relationships intervention program will be implemented on the experimental group. and the control group will be provided with routine nursing care. data will be collected at baseline, the sixth and the ninth month of the third year of study. data will be analyzed using generalized estimating equation measures to evaluate the effect of the intervention program.


Eligibility criteria:
inclusion criteria: * 20 years and older * diagnosed with chronic kidney disease stage 1 to 4 or gfr≧30ml/min/1.73m2 * patients who has significant others * patients who can speak mandarin or taiwanese exclusion criteria: * patient who limited to exercise

Keywords: helping relationships, healthy lifestyle, quality of life
caiman 5 articulating maryland in colorectal cancer surgery

Conditions: Colorectal Cancer

Summary: this voluntary study is part of a post-market-surveillance plan to proactively collect clinical data for the use of caiman 5 articulating maryland in colorectal surgery under daily clinical routine.


Eligibility criteria:
inclusion criteria: * patient´s written informed consent * planned laparoscopic colorectal cancer surgery using caiman 5 articulating maryland (according to the ifu) * age ≥18 years exclusion criteria: * emergency surgery * pregnancy * participation in another surgical study, which might influence the intraoperative process * conversion to open surgery * conversion to another sealing / cutting instrument (instead of caiman 5 articulating maryland)

Keywords: colorectal cancer laparoscopic surgery seal & cut total mesorectal excision (tme) partial mesorectal excision (pme) complete mesocolic excision (cme)
tibial nerve stimulation and postoperative ileus

Conditions: Postoperative Ileus

Summary: postoperative ileus (poi) causes patient's discomfort and leads to an increase of cost of management after colorectal surgery because of an increase of the morbidity rate or of the rate of early rehospitalization after discharge. enhanced recovery programs allowed a reduction of its rate but 20 to 30% of patients will experiment poi. a new approach during preoperative era, using mastication or preoperative physical activity, has been proposed to improve postoperative course. this leads to a vagal activation (action especially on upper gi). sacral stimulation using percutaneous tibial nerve stimulation (ptns) has an effect on lower gi. the aim of this study was to assess the efficacy and the feasibility of ptns during perioperative course, to prevent poi with respect with placebo.


Eligibility criteria:
inclusion criteria: * patients \> 18 years * elective colectomy or proctectomy * agreement for the research exclusion criteria: * chronic inflammatory bowel disease * irritable bowel disease documented * history of surgery on oesophagus or stomach * acetylcholine dysfunction * enterostoma * patient holder of pace-maker

Keywords: percutaneous tibial nerve stimulation randomized controlled study
effects of dry needling technique in hip muscles in subjects with grade i-iii hip osteoarthritis

Conditions: Hip Osteoarthritis

Summary: dry needling is a new treatment technique, addressed to mechanical pain of the neuromusculoskeletal system. recent investigations has developed new hypothesis about the etiology of the osteoarthritis and could be in relation to musculoskeletal disorders, but there is no published studies evaluating the results of this technique in hip osteoarthritis patients. the objective of this trial is to evaluate if dry needling is more effective in symptoms, function, range of motion, strength, muscular length, pain threshold and compared to sham dry needling and control. for this purpose the investigators conduct a randomized controlled trial double-blind (patient and examiner). the investigators included patients diagnosed of hip osteoarthritis grade i-iii by scale of kellgren and lawrence. patients included are randomized into 3 groups one receive dry needling, other sham dry needling and the other is a control. groups receive 3 treatment sessions. the variables are measured at the beginning and end of treatment. and also some variables are measured before and after each session. patients who participated in sham dry needling or control group, when the intervention finish the investigators will be given the opportunity to receive the actual technique.


Eligibility criteria:
inclusion criteria: * diagnosed medically with a x-ray test * american college of rheumatology criteria exclusion criteria: * secondary osteoarthritis by a traumatism, paget disease, inflammatory or metabolic disease, congenital diseases etc. * vascular or neurological disease. * musculoskeletal pathologies in lumbar spine, pelvis or lower limbs * grade iv in kellgren and laurence scale * fear of needles

Keywords: hip osteoarthritis physiotherapy manual therapy
a case control study to identify the role of epigenetic regulation of genes responsible for energy metabolism and mitochondrial function in the obesity paradox in cardiac surgery

Conditions: C.Surgical Procedure; Cardiac

Summary: this is a prospective, single-centre case control comparison of expression of target genes responsible for energy utilisation, mitochondrial function and oxidative stress and levels of histone acetylation/ dna methylation in obese and non-obese adult cardiac surgery patients. the study aims to test several inter-related hypotheses in a consecutive sequence of patients undergoing coronary artery bypass grafting.


Eligibility criteria:
inclusion criteria: * patients with pre-existing paroxysmal, persistent or chronic atrial fibrillation, exclusion criteria: * patients with pre-existing inflammatory state: sepsis undergoing treatment, acute kidney injury within 5 days, chronic inflammatory disease, congestive heart failure. * emergency or salvage procedure. * ejection fraction \<30 %. * patient in a critical preoperative state (kidney disease: improving global outcomes (kdigo) stage 3 aki \[20\] or requiring inotropes, ventilation or intra-aortic balloon pump). * pregnancy.
pharmacokinetics of biphasic insulin aspart 30 and 70 in subjects with type 1 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 1

Summary: this trial is conducted in europe. the aim of this trial is to investigate steady state pharmacokinetics of biphasic insulin aspart 30 and biphasic insulin aspart 70 in subjects with type 1 diabetes.


Eligibility criteria:
inclusion criteria: * type 1 diabetes for at least 12 months * currently on a multiple dose insulin regimen * hba1c maximum 12.0% * bmi (body mass index) below 35 kg/m\^2 * able and willing to perform self-blood glucose monitoring (sbgm) exclusion criteria: * treatment with insulin aspart within the last 14 days prior to this trial * the receipt of any investigational drug within the last 30 days prior to this trial * total daily insulin dose at least 1.8 u/kg * a history of drug abuse or alcohol dependence within the last 5 years * impaired hepatic function * impaired renal function * blood donation within the last nine weeks or haemoglobin below the lower reference limit according to the local laboratory * cardiac disease * severe, uncontrolled hypertension
corset versus ostéosynthese in adult pyogenic spondylodiscitis

Conditions: Spondylodiscitis

Summary: pyogenic spondylitis in adults is usually treated by antibiotics according to bacteria evidenced in a diagnostic intervertebral disc puncture. brace treatment is associated in patients presenting back pain and a risk for vertebral body collapse due to infection with subsequent kyphotic deformity of the thoracolumbar spine. percutaneous minimally invasive posterior spinal instrumentation has evolved over the last decade and indications in infections arouse over the last years. this procedure is interesting as it is performed through small skin incisions only. it avoids paravertebral muscle dissection and thus limits intraoperative bleeding and access morbidity. recent retrospective data suggests that this internal fixation represents a theoretical advantage over brace treatment by lowering back pain and increasing patient's quality of life in the short run, up to 3 months, but no randomized study was published. the patient's autonomy, including walking ability and daily activities, might improve more rapidly after a percutaneous procedure. additionally, the sagittal alignment of the thoracolumbar spine could be better maintained by internal fixation, which might prevent progression into kyphosis and improve long-term outcome. the hypothesis is the superiority of percutaneous minimally invasive instrumentation on brace treatment in term of quality of life, back pain and quality of osseous healing.

safety and efficacy of percutaneous for the indication of pyogenic spondylitis has been demonstrated retrospectively on small cohort studies, which is in line with our clinical experience. although this therapeutic concept seems applicable to patients with spondylitis, the theoretical clinical benefit of minimally invasive surgery remains hypothetic and unclear compared to brace treatment, which might still be regarded as the gold standard.

Eligibility criteria:
inclusion criteria: * adult patients presenting acute pyogenic spondylitis of the thoracolumbar spine * back pain at a minimum of 4 out of 10 on vas * diagnostic mri and disc puncture + microbiological analysis required for antibiotic treatment and/or blood culture * vertebral body involvement (osteolysis) \< 50% of vb height documented on ct exclusion criteria: * postoperative pyogenic spondylitis or infection after spinal instrumentation spinal tuberculosis and mycosis * contra-indications for surgery or general anaesthesia * general septic conditions acute endocarditis documented by sonography * patients presenting another major abcess or an epidural abscess * absence of vertebral body involvement (osteolysis) on ct or minor vb involvement less than 10% of vb height (surgery not indicated) * major destruction of vertebral body (\>50%) on ct (surgery mandatory) patients with concomitant bacterial endocarditis

Keywords: spondylodiscitis spinal infection back pain quality of life fusion minimal invasive surgery brace treatment
assessment of oral health status of children with primary ciliary dyskinesia

Conditions: Primary Ciliary Dyskinesia; Caries,Dental; Quality of Life; Saliva Altered; Erosion, Dental Enamel

Summary: the aim of this study is to compare the oral health findings, salivary parameters and pediatric oral health related quality of life of children with primary ciliary dyskinesia (pcd) with healthy children

primary ciliary dyskinesia (pcd) is a rare genetic disorder that affects the function of cilia, which are tiny hair-like structures responsible for moving mucus and other substances in the respiratory tract and other parts of the body. dysfunctional cilia lead to impaired mucociliary clearance, resulting in chronic respiratory infections, sinusitis, and bronchiectasis. pcd can also cause situs inversus, where internal organs are mirrored from their normal positions, and other complications like chronic otitis media and fertility issues. early diagnosis and management are crucial to prevent progressive lung damage and improve the quality of life in affected individuals. this study aims to compare the oral and dental health of children diagnosed with primary ciliary dyskinesia (pcd) to that of healthy controls. the study includes assessments of dental caries (using dmft, dmft, and icdas ii indices), salivary parameters (flow rate, ph, buffering capacity, oxidant-antioxidant levels, tissue factor activity), enamel defects (using the modified developmental defects of enamel index), and oral hygiene (gingival and plaque indices). the pediatric oral health-related quality of life (poql) scale will be used to evaluate the impact of oral health on quality of life.

Eligibility criteria:
inclusion criteria: * not having any systemic disease. * not being on any regular medication. exclusion criteria: * having any systemic disease. * being on any regular medication.

Keywords: primary ciliary dyskinesia erosion, dental oral health quality of life dental caries
study to test a marketed drug in the treatment of menstrual migraine (0462-071)

Conditions: Migraine

Summary: the purpose of this study is to test the effectiveness of a marketed drug in the treatment of a menstrual migraine attack.


Eligibility criteria:
inclusion criteria: * female patient at least 18 years old * patient has menses approximately monthly * patient has at least a 5 month history of migraine and at least a 6 month history of menstrual migraine exclusion criteria: * pregnant and/or nursing * cardiovascular disease * uncontrolled hypertension
fralyse trial: comparison of the classical rt-pa procedure with a longer procedure in acute ischemic stroke

Conditions: Stroke, Acute

Summary: data from the literature have suggested that a longer time of thrombolysis might be more effective in ischemic stroke. we, the investigators at hospices civils de lyon, have designed a randomized protocol to test this hypothesis. moreover, the therapeutic window is 7 hours. rt-pa (alteplase) is injected intravenously in the 2 arms of the study for a duration of 60 minutes in the arm with a "classical dose" and 90 minutes in the arm with a "low dose-longer infusion". this is a study of the outcome at 90 days.


Eligibility criteria:
inclusion criteria: * symptoms of ischemic stroke * presence of a deficit measurable with national institutes of health stroke scale (nihss) * lack of any hemorrhagic lesion on the computed tomography (ct) scan at entry * time of therapy less than 7 hours after onset of stroke * permanent or aggravating symptoms * ages 18-81 exclusion criteria: * lack of cerebral infarction or of cranial trauma within 3 weeks before therapy * no surgery within 14 days before therapy * history of cerebral bleeding * blood pressure: systolic \>185 mmhg and/or diastolic \>110 mmhg * minor symptoms or symptoms rapidly improving * gastro-intestinal or urinary hemorrhage within 21 days * arterial puncture within 7 days before therapy * epileptic seizure at the beginning of stroke * patients under oral anticoagulants or having received heparin within 48 hours, and with elevated activated partial thromboplastin time (aptt) * patients with elevated international normalized ratio (inr) or thrombocyte count \< 100 x 10\^9 * blood glucose value \ 22.2 mmol/l * cardiac, pulmonary, hepatic or renal failure, not allowing a study over 3 months * history of gastric ulcer within 15 days; gestation and menstruation

Keywords: rt-pa thrombolysis acute ischemic stroke
feasibility of bright light therapy on fatigue, sleep and circadian activity rhythms in lung cancer survivors

Conditions: Fatigue; Sleep Disturbance; Circadian Dysregulation

Summary: the purpose of this study is to determine the feasibility of a morning bright light therapy intervention for fatigue, sleep disturbances, and circadian activity rhythms in lung cancer survivors.

a randomized controlled trial to test the effects of morning bright light therapy on fatigue, sleep disturbances, and circadian activity rhythms in lung cancer survivors.

Eligibility criteria:
inclusion criteria: * stage i-iii non-small cell lung cancer survivors * must be at \>6-weeks and \< 3 years post-surgical resection * must have diagnosis fatigue and/or sleep disturbances exclusion criteria: * individuals clinically unstable. * mania, bipolar disease or seizure disorder * macular degeneration or glaucoma. * currently receiving chemotherapy or radiation.

Keywords: fatigue sleep disturbances circadian activity rhythms
repetitive transcranial magnetic stimulation (rtms) in fibromyalgia

Conditions: Fibromyalgia

Summary: this study aims to evaluate the effectiveness of 10 hz neuronavigated repetitive transcranial magnetic stimulation (rtms) to the left dorsolateral prefrontal cortex (dlpfc) on pain, stiffness, fatigue, depression/anxiety, quality of life and cognitive functions in fibromyalgia syndrome (fms).

this is a single-center, prospective, randomized, double-blind, sham-controlled study in two-arm parallel-group design. twenty participants will be randomized into 2 groups. randomization will be performed using computer-generated block randomization with 1:1 allocation between the active rtms group (group 1) and the sham-control group (group 2). group 1 will receive high frequency repetitive transcranial magnetic stimulation (10hz-hf-rtms)-a total 14 sessions of hf-rtms, 10 sessions daily (5 days/week, 2 weeks) and 4 sessions weekly (1 day/week, 4 weeks). group 2 will receive sham stimulation-a total 14 sessions of sham-rtms, 10 sessions daily (5 days/week, 2 weeks) and 4 sessions weekly (1 day/week, 4 weeks).all patients will be evaluated with pain severity (vas-10mm),stiffness severity (vas-10mm), fibromyalgia impact questionnaire (fiq), fatigue severity scale (fss), hospital depression anxiety scale (hads), addenbrook cognitive examination-revised version (ace-r).patients will be questioned for the safety of treatment. available drug therapies will be continued in both groups. patients and clinical raters will be blinded to treatment. all patients will be reviewed by the investigator in terms of rtms treatment safety and motor threshold determination before each treatment session and observed for possible side effects after treatment. all side effects will be recorded. magnetic stimulation will be applied using neurosoft-neuro ms/d with a figure-of-eight-shaped coil. rtms therapy will be applied under the guide of neuronavigation with the following parameters: target-left dlpfc, with the %90 of the rmt, 10 hz stimulation for 5 seconds intervals (on) with 25 seconds inter-train intervals (off), 15 minutes, 1500 pulses.

Eligibility criteria:
inclusion criteria: * adults (age between 18-65 years) * diagnosis of fibromyalgia syndrome according to 2016 fibromyalgia diagnostic criteria * the mean pain intensity is vas ≥ 4/10 * stable treatment for at least last 3 months * patients accepting participation by signing an informed consent form exclusion criteria: * to have a clinical condition to be contraindicated for tms (metallic implant, cardiac pace, pregnancy, lactation, epilepsy, head trauma, history of cranial operation...) * the presence of malignancy * systemic rheumatic diseases * major orthopedic / neurological problems that limit daily life activities * alcohol or drug addiction * major depression / personality disorder history * have received tms treatment before * pregnancy or breastfeeding

Keywords: fibromyalgia, neuronavigated-rtms, pain, stiffness, fatigue
study of tadalafil for the treatment of diabetic patients with symptoms of upset stomach and delayed stomach emptying

Conditions: Gastroparesis

Summary: the purposes of this study are to determine whether an experimental drug known as tadalafil can reduce symptoms of dyspepsia (fullness after eating, inability to finish a regular meal, bloating, discomfort or pain in the upper abdomen, belching after meals, nausea, vomiting) in diabetic patients, and/or reduce the amount of time the stomach takes to empty the contents of a standard meal. the safety of tadalafil given once daily for 8 weeks in this population will also be studied.


Eligibility criteria:
inclusion criteria: * diagnosis of diabetes mellitus * delayed gastric emptying * 3 month minimum history of chronic upper abdominal discomfort * symptoms of dyspepsia (upset stomach) exclusion criteria: * major gastrointestinal surgery or medical conditions known to affect gastric motility * irritable bowl syndrome * medications known to affect gastric motility * angina treated with nitrates * uncontrolled diabetes mellitus and history of certain heart problems
acetylsalicylic acid and colorectal cancer prevention: exploring the platelet function of its mechanism of action

Conditions: Colorectal Cancer

Summary: in a preliminary study in healthy subjects, the investigators determined the pharmacokinetic and pharmacodynamic of enteric-coated acetylsalicylic acid (asa) (adiro 100 mg, bayer), and the variability (coefficient of variation), accuracy and precision of a novel biomarker of asa action, i.e., quantification of the extent of cox-1 acetylation at serine-529, using a stable isotope dilution liquid chromatography multiple reaction monitoring/mass spectrometry (lc-ms) technique. now, the investigators will perform a clinical study in individuals undergoing colorectal cancer (crc) to validate the hypothesis that that low-dose asa given once daily is acting primarily by selectively acetylating platelet cox-1 and suppressing its activity throughout the 24-hour dosing interval. in contrast, it is expected that the inhibitory effect on extra-platelet sources of cox-1 will be short-lasting, if any, affecting only partially cox-1, and this effect will be completely reversed at 24 hours after dosing. this is an important point which will strengthen the platelet hypothesis underpinning the apparent adequacy of a 24-hour dosing interval of asa administration for the anticancer effect detected in cardiovascular trials. these patients will be stratified into individuals with adenomas/carcinomas (20 to 30%) and patients without clinically detected adenomas/carcinomas (about 70 to 80%).


Eligibility criteria:
inclusion criteria: 1. men and women, aged ≥ 18 and ≤ 69. 2. patients should have an indication for screening colonoscopy 1. first degree relative of patient with crc. 2. personal history of adenomas. 3. people older than 50 and fobt positive 3. routine hematological and biochemical parameters within the normal range. exclusion criteria: 1. allergy to asa or other nsaids. 2. previous use of asa, nsaids, antiplatelet agents, corticosteroids or misoprostol in the previous 15 days and/or anticipated need for these drugs during the study period. 3. peptic ulcer history or any other gastrointestinal disease that could be considered a contraindication for asa use without the concomitant use of a proton-pump inhibitor. 4. subjects with coagulation disorder or serious comorbid condition. 5. malignancies, excluding crc, diagnosed in the previous 5 years 6. cigarette smoking, history of drug or alcohol abuse 7. pregnant women or breast feeding