Kornimate/medical-research-clean huggingface dataset:
antibiotic prophylaxis to prevent obesity-related induction complications in nulliparae at term

Conditions: Obesity; Induction of Labor Affected Fetus / Newborn

Summary: obesity increases the risk of pregnancy complications, including among others puerperal infections and cesarean delivery, and risk rises with increasing body mass index (bmi). class iii obesity is an indication for delivery by 39 weeks, and these patients have a high rate of labor induction. in nulliparous women from the general population (obese and non-obese), labor induction at 39 weeks (compared to expectant management) is associated with less morbidity and a lower cesarean rate. antibiotic prophylaxis, standard before cesarean delivery, is associated with less post-cesarean infection if azithromycin is added to the standard cefazolin. in this placebo-controlled pilot trial, investigators will estimate the parameters necessary to calculate the sample size for a planned multicenter clinical trial of prophylactic antibiotics administered at the start of labor inductions of morbidly obese nulliparous women at term.

investigators will enroll consenting women delivering at the children's hospital at ou medical center who meet enrollment criteria. flyers will be distributed to providers to give to women who may be eligible for the study at prenatal visits, so that they may review the information prior to presenting for their induction of labor. labor induction may be a scheduled procedure. however, many inductions occur in an unscheduled fashion due to medical or obstetric indications. therefore, it is difficult to predict which women will ultimately require labor induction and at what gestational age they will require it, so it is not feasible to approach and consent all women during a clinic visit prior to labor induction. distribution of flyers will allow patients to have information about the study prior to presenting for labor induction. furthermore, unlike women in spontaneous labor, women being consented just prior to a labor induction are not vulnerable in the same way as one might consider a patient in labor, since they will not have the distraction and discomfort of uterine contractions that are presenting in laboring patients.

Eligibility criteria:
inclusion criteria: * bmi ≥30 * no prior deliveries at or beyond 20 weeks gestation * undergoing induction of labor * gestational age 37 weeks or more * age 15-45 exclusion criteria: * fetal death prior to labor induction * known fetal anomaly * multiple gestation * ruptured membranes for more than 12 hours * chorioamnionitis or other infection requiring antibiotics at the start of the labor induction * previous myometrial surgery * allergy to either drug used in the protocol (cefazolin or azithromycin)
addressing emotional and cognitive factors in behavioral weight loss treatment

Conditions: Overweight; Obesity

Summary: behavioral weight loss, the current treatment of choice for moderate obesity, achieves impressive short term results, however, weight regain following treatment is a major problem. over 50% of participants in behavioral weight loss programs report difficulty with internal antecedents to unhealthy weight control behaviors and this difficulty is associated with weight regain following treatment. current treatment approaches do not adequately address these antecedents. the aim of this series of studies is to develop, implement, and evaluate a behavioral weight loss program modified to provide participants with skills to deal effectively with affective and cognitive difficulties. the study targets men and women with bmi of 27-40 who self-report difficulty with emotional and/or cognitive antecedents to unhealthy weight control behaviors. the study is an uncontrolled pilot study in 20 participants to initially assess acceptability and efficacy of the innovative treatment. the long-term goal of this research is to improve the weight loss maintenance outcomes of behavioral weight loss programs by addressing affective and cognitive antecedents to unhealthy weight control behaviors.


Eligibility criteria:
inclusion criteria: * age between 21 and 70 years * body mass index between 27 and 40 * score 5 or above on the internal disinhibition scale of the eating inventory exclusion criteria: * are currently participating in a weight loss program and/or are taking a weight loss medication or lost greater than or equal to 5% of body weight during the past six months * are pregnant, lactating, less than 6 months postpartum or plan to become pregnant during the time frame of the investigation * report a heart condition, chest pain during periods of activity or rest, or loss of consciousness on the physical activity readiness questionnaire (par-q). individuals endorsing joint problems, prescription medication usage, or other medical conditions that could limit exercise will be required to obtain written physician consent to participate.

Keywords: behavioral weight loss
intrapartum vulval and perineal cleansing using chlorhexidine versus normal saline

Conditions: Maternal Infection During Pregnancy

Summary: maternal infection during pregnancy is one of the leading causes of maternal mortality, accounting for 10.7% of maternal deaths worldwide (\~37,000 annually). majority of maternal infection occurs during intrapartum (36%) and postpartum (47%) period, of which the genital tract is the source of infection in 89% of intrapartum and 54% of postpartum sepsis. introduction of skin flora into the genital tract during vaginal examination in women with rupture of membranes or active labour may cause intrapartum and puerperal sepsis. we hypothesize intrapartum vulval and perineal cleansing before vaginal examination could reduce the chance of peripartum infection caused by introducing the skin flora to intrauterine environment. we plan to carry out a randomized controlled trial of intrapartum vulval and perineal cleansing using chlorhexidine, compared sterile water, prior to vaginal examination during labour and its effect on maternal and neonatal sepsis.


Eligibility criteria:
inclusion criteria: * all women age ≥ 18 years old * live singleton pregnancy * planned vaginal delivery * term in labour (after 37+0 weeks of gestation) * availability of gbs result at 35-37 weeks exclusion criteria: * preterm delivery (between 24+0 to 36+6 weeks of gestation) * multiple pregnancy * presence of fever before onset of labour * history of antibiotics use 7 days before onset of labour * history of adverse reaction to chlorhexidine * planned caesarean delivery * planned delivery in other units * women with autoimmune disease, immunodeficiency, human immunodeficiency virus or on long term steroids * stillbirth * known genital herpes * genital wart during pregnancy
topical instillation of tranexamic aacid in bronchoscopy to decrease bleeding during entobronchial & transbronchial biopsiy: a prospective double blind placebo controlled study

Conditions: Bronchoscopy Biopsy

Summary: bleeding during transbronchial ro endobronchial biopsy is rather a common complication. mostly this is an insignificant bleeding, but in 3% of the biopsies there is a substantial amount of bleeding that requires a special treatment or follow up. the goal of this study is to examine whether submission of tranexamic acid during the biopsy could diminish the amount of bleeding.


Eligibility criteria:
inclusion criteria: * patient that are candidates to endobronchial or transcronchial biopsy exclusion criteria: * s/p mi or cva or pe or dvt . * s/p thrombophilia. * patients under coagulation therpay * chronic renal failure * pregnancy
validation of the arabic version of the caries questionnaire

Conditions: Dental Caries in Children

Summary: arabic is one of the most spoken languages in the world; however, the caries-qc questionnaire which evaluate the effect of oral diseases and disorders on children's oral health-related quality of life has not yet been validated in arabic speaking children. so the purpose of this study was to translate the caries-qc into arabic and test the measurement properties of the arabic version of the caries-qc for use in children with dental caries who speaks arabic .

dental caries is a major public health problem. it has been estimated that 621 million children in the world have untreated dental caries . dental caries always manifests with significant pain, affecting oral health-related quality of life (ohrqol) and well-being. several measures were widely used to comprehensively evaluate the effect of oral diseases and disorders on children's ohrqol. however, most of these measures were 'generic' measures, and they may fail to detect small, clinically important changes related to specific oral diseases. gilchrist et al recently developed the caries impacts and experiences questionnaire for children (caries-qc) in order to address this issue. preliminary findings have confirmed that caries impacts and experiences questionnaire for children measure had good reliability, validity, and responsiveness. however, the original caries-qc was an english measure; so appropriate translation and cultural adaptation should be done in order to be used in other culture and language. arabic is one of the most spoken languages in the world; however, the caries-qc has not yet been validated in arabic speaking children. so the purpose of this study was to translate the caries-qc into arabic and test the measurement properties of the arabic version of the caries-qc for use in children with dental caries who speaks arabic .

Eligibility criteria:
inclusion criteria: 1. child in age from 5-16 years . 2. child with active caries 3. child speaks arabic. exclusion criteria: 1. child with dental traumatic injuries . 2. child has oral mucosal diseases. 3. child has cleft lip and or palate . 4. child having severe medical or mental conditions. 5. child who cannot understand the question even with help

Keywords: caries-qc ,validity ,reliability, arabic, dental caries
use of harmonic scalpel to decrease lymphatic and chest tube drainage after lymph node dissection with lobectomy.

Conditions: Lung Cancer

Summary: in an effort to elucidate whether the harmonic scalpel will improve sealing lymphatics and decrease lymphatic drainage thereby decreasing the length of time that chest tubes are required and minimizing length of stay; the harmonic scalpel will be compared to a control group which uses electrocautery. this study will assess these two different methods to determine if there is a notable decrease in the amount of drainage with one versus the other.

lymph node dissection is an integral part of the surgical management of lung cancer. knowledge of lymph node status plays a key role in therapeutic decision making and prognosis. associated with this dissection comes the propensity for lymphatic leakage, increased chest tube drainage, prolonged retention of chest tubes in the postoperative period and increased patient length of stay. our center performs complete mediastinal node dissection of all relevant regional lymph nodes which generally include paratracheal, pretracheal, subcarinal, hilar and paraesophageal nodes. the current standard of practice for the dissection of the lymph nodes includes the use of the harmonic scalpel or electrocautery. known risk of electrocautery include localized nerve damage, cardiac arrhythmias and damage to the tissue sample/specimen that is used for pathology. the harmonic scalpel technology has recently become available for use. current experience with the harmonic scalpel suggests that there is less localized nerve damage, less incidence of arrhythmias, less damage to the tissue sample and less lymph leakage. there is no published data to support this hypothesis, thus the purpose of this study.

Eligibility criteria:
inclusion criteria: * patients undergoing resection for stage 1, 2 or 3a lung cancer. * patients between the ages of 20-75. exclusion criteria: * history of congestive heart failure. * history of renal failure, ie., creatinine greater than 2.2. * patients with bulky or matted lymph nodes in stage 3a. * current pregnancy. * current participation in another study involving an investigational device or drug.

Keywords: lung cancer lymph node dissection
acute effects of vibration on shoulder flexibility - experimental controlled trial

Conditions: Healthy

Summary: whole body vibration (wbv) can help to improve muscle flexibility by stimulating the neuromuscular functions. but there is a dearth in the literature to prove its effectiveness in improving the flexibility of the upper limb muscles. therefore the purpose of the study is to determine the effects of vibration on improving upper limb flexibility. this experimental research will be conducted by recruiting participants at the age of 19 to 27 with no histories of injuries on the upper limb. they will be randomly assigned into two groups; experimental (with vibration) and control (no vibration) group. the wbv machine will be used to provide vibration to the upper extremities by placing both palms on the vibration platform. the outcome measure of active chest flexibility and shoulder reach flexibility will be performed pre and post vibration.


Eligibility criteria:
inclusion criteria: * ages of 19 to 28 * no athletic background exclusion criteria: * shoulder pain and injury within 12 months, recent back pain and neck pain, recent fever and high blood pressure.

Keywords: whole body vibration
an observational study to assess patient satisfaction and control of psoriasis with calcipotriene/betamethasone dipropionate (taclonex®) topical suspension, and effect on quality of life

Conditions: Psoriasis Vulgaris

Summary: the purpose of this study is to document quality of life, patient satisfaction, effect on itching, and control of psoriasis vulgaris associated with use of calcipotriene/betamethasone dipropionate (taclonex®) topical suspension 0.005% / 0.064% for treatment of plaque psoriasis under real-life conditions.


Eligibility criteria:
inclusion criteria: 1. signed and dated informed consent obtained prior to any study related activities 2. aged 18 years or above 3. either sex 4. any race or ethnicity 5. attending a hospital outpatient clinic or the private practice of a board-certified dermatologist, dermatology-certified nurse practitioner or physician assistant trained in dermatology 6. clinical diagnosis of psoriasis vulgaris involving scalp and/or body amenable to treatment with a maximum of 100 g of topical medication per week. 7. patients who receive a prescription of calcipotriene/betamethasone dipropionate (taclonex®) topical suspension 0.005% / 0.064% as per an investigator's clinical judgment and in accordance with the us label, and who have access to the medication 8. able to communicate with the investigator, read and understand english, and understand and comply with the requirements of the study exclusion criteria: 1. prior treatment with calcipotriene/betamethasone dipropionate (taclonex®) topical suspension, 0.005%/0.064%. 2. contraindications or any warnings/precautions according to the us label. 3. current participation in any other interventional clinical study. 4. females who are pregnant, breast-feeding, or females of child-bearing potential wishing to become pregnant during the study.

Keywords: plaque psoriasis calcipotriene betamethasone dipropionate topical
use of rectal dialysis technique to measure rectal 5-asa levels in healthy volunteers receiving asacol

Conditions: Ulcerative Colitis

Summary: the investigators plan to develop a novel method of estimating 5-asa levels in the rectum at a mucosal level using in vivo rectal dialysis technique towards the eventual goal of determining the optimal dosing of asacol® that would provide therapeutic levels of 5-asa in the left colon.

asacol® is mesalazine in a ph-dependent tablet (eudragit s) that remains intact until reaching the terminal ileum. the tablet dissolves at a ph 7 or greater, allowing mesalazine release in the terminal ileum and throughout the colon; hence, it would be anticipated that this form of 5-asa will produce higher concentrations in the left colon in patients with active ulcerative colitis compared to other immediate release forms of 5-asa. however, preliminary research using dynamic computer modeling and simulation predicted that patients with active ulcerative colitis (characterized by an increased stool frequency) treated with asacol® and lialda (another delayed release formulation) will achieve very low 5-asa levels in the sigmoid colon and rectum. the model predicts that these 5-asa preparations will be relatively ineffective in treating the left side of the colon in active ulcerative colitis.

Eligibility criteria:
inclusion criteria: * eligible subjects would be healthy males and females * 18-45 years of age (inclusive) * within 20% of normal body weight at screening * who are able to give written informed consent. exclusion criteria: * history of any chronic illness * evidence of significant organic or psychiatric disease on a brief health questionnaire * a history or presence of any condition causing malabsorption or an effect on gastrointestinal motility * a history of any gastrointestinal surgery * a history of acute or chronic renal insufficiency * pre existing liver disease * a history of severe allergic reaction to salicylates, aminosalicylates or any of the ingredients of asacol® tablets or a history of multiple food/drug allergies or if they are pregnant or lactating. * subjects will be required to refrain from any prescription or nonprescription drug or herbal products except their birth control medications for gastrointestinal disorders for 7 days prior to dosing and during the study, till its completion at the end of the fifth visit.

Keywords: pharmacokinetics aminosalicylates mucosal levels rectal dialysis
carpel tunnel syndrome and physical therapy modalities

Conditions: Carpal Tunnel Syndrome

Summary: carpel tunnel syndrome (cts) is very common complain during pregnancy with high percentage to continue postnatal. conservative treatment is more recommended in these cases. there are many physical therapy modalities proposed to treat cts without knowing which modality is better than the other. so the aim of this study to compare the effect of two modalities in treating cts in postnatal females.

carpal tunnel syndrome (cts) is one of the most common peripheral nerve entrapment disorders in the upper limb. cts is common during pregnancy especially in the third trimester as well, a significant percentage of females postnatal may still have some complaints up to at least 3 years postnatal. purpose: to compare the effect of pulsed magnetic field (pemf) versus ultrasound (us) in treating patients with cts. forty postnatal female patients with idiopathic cts were assigned randomly into two equal groups. one group received pemf with nerve and tendon gliding exercises for the wrist 3 times for week for 4 weeks. the other group received us plus the same exercises. pain level, sensory and motor distal latencies of the median nerve (msdl and mmdl), sensory and motor conduction velocities of the median nerve (mscv and mmcv), functional status scale and hand grip strength were assessed pre and post treatment

Eligibility criteria:
inclusion criteria: * mild to moderate cts * positive electro diagnostic findings: prolonged median motor distal latency (mmdl) above 4 ms, and below 6ms. * prolonged median sensory distal latency above 3.5 ms . * positive phalen and tinel test. * subjects scored pain intensity more than 5 in visual analogue scale (vas). exclusion criteria: * severe cases with delayed motor distal latency \> 6ms. * orthopedic or neurological disorders of neck or the upper limb as cervical radiculopathy. * pronator teres syndrome or double crush syndrome. * pre- existing cts before their last pregnancy, current pregnancy. * diabetic neuropathy and thoracic outlet syndrome. * wasting of thenar muscles, ulnar neuropathy. * rheumatoid arthritis, previous fractured carpal bone and previous surgery in the forearm especially transverse ligament release

Keywords: median nerve wrist joint carpal tunnel
drug eluting stent registry of thrombosis

Conditions: Coronary Artery Disease

Summary: multicenter, case-control study, to collect data regarding incidences of late and very late drug-eluting stent thrombosis with the aim of identifying trends and possible correlates of stent thrombosis.


Eligibility criteria:
inclusion criteria: * patients over 18 years of age * case subjects: patients who have experienced definite late or very late drug-eluting stent thrombosis * control subjects: patients who underwent drug-eluting stent implantation at the same facility and in the same time period as a matched case subject, and have not experienced drug-eluting stent thrombosis. exclusion criteria: * patients not meeting the above inclusion criteria
a study of icp-033 in patients with advanced solid tumors

Conditions: Patients With Advanced Solid Tumors

Summary: a dose finding study to evaluate the safety, tolerability and pharmacokinetics and preliminary anti-tumor activity of icp-033 tablets in patients with advanced solid tumors.


Eligibility criteria:
inclusion criteria: 1. eastern cooperative oncology group (ecog) performance status of 0-1; 2. patients with histologically confirmed locally advanced unresectable or metastatic solid tumors; 3. at least one measurable lesion according to recist 1.1. exclusion criteria: 1. pregnant and lactating women, or women planning to become pregnant during the study through at least 6 months after the last dose of study drug. 2. patients with unstable primary central nervous system (cns) tumors or cns metastases. 3. patients who have active or history of interstitial lung disease or noninfectious pneumonia. 4. patients with qtc \> 450 ms in males and \> 470 ms in females on ecg at screening, or other clinically significant abnormalities in the ecg at the discretion of the investigator. 5. patient with the medication history and surgical history as stated in the protocol 6. those who are unsuitable for blood collection or contraindicated for blood collection. 7. other conditions considered unsuitable for participation in this trial at the discretion of the investigator.
ffi and pr could improve bowel cleansing.

Conditions: Bowel Preparation

Summary: background:the use of enhanced instruction can improve the efficiency of education for bowel preparation regimens. researchers hypothesized that face-to-face instruction and personalized intervention for inpatient could improve successful bowel preparation rate and patient's compliance with regimens. methods:this was an endoscopist-blind,randomized controlled trial. 320inpatients were randomized 1:1 in one of the two study groups. the intervention group received face-to-face instruction and personalized intervention for bowel preparation protocol, while control group received the standard bowel preparation protocol. patients'demographics, bowel preparation quality, colonoscopy completion and attendance were recorded. logistic regression was performed to identify predictors of bowel preparation failure.


Eligibility criteria:
inclusion criteria: * inpatients undergoing colonoscopy. * patients older than 18 years. exclusion criteria: * prior surgery of colorectal resection; * suspected colonic stricture or perforation; * incomplete or complete bowel obstruction; * use of prokinetic agents or purgatives within 7 days; * patients with severe gastrointestinal diseases, such as intestinal obstruction or perforation, active ulcerative colitis, toxic colitis and toxic megacolon;; * pregnancy or lactation; * inability to prepare bowel; * unable to give informed consent.

Keywords: bowel preparation; face-to-face instruction; personalized intervention