Kornimate/medical-research-clean huggingface dataset:
a patient-centered approach to successful community transition after catastrophic injury

Conditions: Spinal Cord Injury; Peer Group

Summary: shepherd center is bringing a more patient-centered focus to educational, peer-support, and technology resources offered to patients with spinal cord injury and their families and is evaluating these changes. approximately 740 patients have provided information about healthcare utilization following inpatient rehabilitation. this information will help shepherd center staff follow utilization trends and plan programs targeted at the high-use areas.

research efforts are transforming the educational, peer-support and technology resources offered to patients and their caregivers, and evaluating how these changes help improve outcomes, including building patients' sense of self-efficacy - the belief that they can effectively manage their own care. goals of the three focus areas include: a. patient and family education revamp patient education modules for bladder management, skin management, and medical complications management to follow the chronic disease self management approach that replaces didactic lectures with participant-focused problem solving discussions led by peers (persons with sci). multiple baseline implementation approaches will be evaluated in interrupted time series analyses. b. peer mentoring and peer-led self-management training the peer mentor randomized clinical trial is reported separately on clinicaltrials.gov and not repeated here. c. patient and family web portal shepherd center, along with our collaborators at craig hospital in denver, colorado, are developing an engagement portal to provide a mechanism for patients to manage all aspects of injury following rehabilitation discharge and share information with other providers and caregivers.the portal will become a standard part of rehabilitation care and discharge planning for all shepherd center patients - starting first with patients with spinal cord injuries and later expanding to others. stakeholders will be actively involved in providing feedback about portal usability and content so that the product continues to meet their needs.

Eligibility criteria:
inclusion criteria: * patient receiving inpatient rehabilitation at shepherd center following spinal cord injury * discharge to community setting exclusion criteria: * discharge to non-community setting * patient without spinal cord injury at shepherd center
study to assess the safety and efficacy of modified-release prednisone (lodotra®) therapy in patients with active rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of the study is to compare the safety and efficacy, with regards to the signs and symptoms, of mr prednisone (lodotra®) versus placebo in combination with standard disease modifying anti-rheumatic drug (dmard) treatment in patients with active rheumatoid arthritis.

study with completed results acquired from horizon in 2024.

Eligibility criteria:
inclusion criteria: * documented history of ra in agreement with acr criteria * dmard treatment for ra greater than or equal to 6 months, with a stable dose greater than or equal to 6 weeks prior to screening visit * duration of morning stiffness greater than or equal to 45 minutes * greater than or equal to 4 swollen joints (out of 28) * greater than or equal to 4 tender joints (out of 28) exclusion criteria: * suffering from another disease, which requires glucocorticoid treatment during the study period * synovectomy within 4 months prior to study start * use of glucocorticoids: * continued use of systemic glucocorticoids within 4 weeks prior to screening visit * intermittent use of glucocorticoids within 2 weeks prior to screening visit. * joint injections within 6 weeks prior to screening visit * topical glucocorticoids must be stopped at screening visit * use of biologicals such as: tumor necrosis factor α (tnfα) inhibitors and other compounds within 5 serum half lives prior to screening visit * pregnancy or nursing

Keywords: signs and symptoms autoimmune diseases joint diseases arthritis connective tissue diseases arthritis, rheumatoid rheumatic diseases predniso(lo)ne
treatment in occupational therapy with significant activities to improve quality of life

Conditions: Dementia

Summary: we followed a pretest-posttest non-equivalent control group experimental design study comparing two cohorts of patient with different types of dementia. approximately 250 patients will be screened to achieve 240 participants, divided in two cohorts (120 each), furthermore each cohorts was divided in other two groups (experimental group (60 each) and control group (60 each) the first one followed up by private centres in spain endowed with occupational therapy and the second by public centres in the region of modena.

the course of dementia goes through different stages and during the moderate and advanced stages cognitive decline and functional deterioration are frequently accompanied by the so-called behavioural and psychological symptoms of dementia (bpsd), that put severe stress on the persons with dementia (pwd), on their families and on the health system. worldwide consensus guidelines recommend non-pharmacological approaches to be first line. the occupational therapist studies human activity as a therapeutic resource to prevent and treat physical and/or psychosocial difficulties, in order to improve the person's quality of life. subjects were not randomly assigned to different treatment groups (control group and experimental group); instead, consecutive sampling was chosen by assigning subjects based on an odd-and-even-numbered technique (odd subjects were assigned to the control group and even subjects to the experimental group). both groups presented the same pathological, cultural, and sexual characteristics, and belonged to the same age group.

Eligibility criteria:
inclusion criteria: * a diagnosis of primary dementia (dsm v) * a mmse score ≤ 24 * a npi global score ≥ 32/144 * a treatment with significance activities in occupational therapy * live in a nursing home exclusion criteria: * presence of uncontrolled medical disease potentially contributing to the cognitive decline and bpsd * concomitant psychiatric disorders or chronic alcoholism * concomitant diseases severe enough to reduce life expectancy \< 6 months

Keywords: occupational therapy dementia significance activities no-pharmacological treatment
a retrospective data analysis of therapy with prrt combined with lanreotide autogel® for neuroendocrine tumours

Conditions: Neuroendocrine Tumours

Summary: the objective of the prelude study is to describe the use of lanreotide autogel® (lan atg) combined with peptide receptor radionuclide therapy (prrt) in the treatment of progressive neuroendocrine tumours located in the lung or in the digestive system as there is currently limited data on these treatments used together for these types of neuroendocrine tumours.


Eligibility criteria:
inclusion criteria: * histopathologically confirmed metastatic well differentiated neuroendocrine tumour (net) (grade g1 or g2 according to the world health organisation 2010 classification): gastro-entero-pancreatic (gep) or bronchopulmonary (bp) primary tumour, or tumour of unknown origin believed to be of gep origin, if a primary tumour elsewhere was excluded by multiphasic computerised tomography (ct) or magnetic resonance imaging (mri) * disease progression radiologically documented with evaluable imaging (ct or mri, digital or print-out), performed within 12 months and within 6 months prior to the first prrt/lan atg cycle * metastatic- or locally-advanced, hormonal functioning or nonfunctioning gep-net or bp-net; * confirmed presence of somatostatin receptors (sstrs) on all target lesions based on positive sstr scintigraphy (octreoscan®/99mtc-tektrotyd) or 68ga sstr positron emission tomography-computerised tomography (pet/ct) imaging, i.e. grade ≥2 respectively per the krenning scale or per the modified krenning scale exclusion criteria: * absence of information regarding lan atg treatment: dose received, start date, frequency of injections * no ct or mri within 12 months and within 6 months preceding the baseline, or at the end of the last prrt/lan atg cycle * absence of information on cumulative activity of prrt with 177 lutetium (177lu) dotatoc or 177lu-dotatate received (at least 500 mci (equivalent to 18.5 gbq), for the entire therapy) * prrt prior to the first combination cycle of prrt/lan atg
effects of preoperative rehabilitation on tendon healing and bone mineral density after aclr

Conditions: Anterior Cruciate Ligament Rupture

Summary: to explore the effect of preoperative exercise rehabilitation on bone mineral density, tendon bone healing, change of cartilage, and gait feature in patients with anterior cruciate ligament rupture.

anterior cruciate ligament (acl) injury is one of the most common sports injuries. it is a serious knee injury. the fracture of acl can cause functional instability of knee joint, damage of meniscus and articular cartilage, and even induce knee osteoarthritis and other diseases. it has great influence on knee joint and even lower limb function of patients. arthroscopic acl reconstruction has become the first choice in clinical treatment of acl fracture. acl fracture can cause local knee joint osteoporosis, and reconstruction surgery can also affect tendon bone healing, bone canal enlargement, rehabilitation period, gait, articular cartilage degradation, etc. this study intends to conduct preoperative rehabilitation intervention for young people with anterior fork rupture, and explore the effects of exercise rehabilitation on knee bone mineral density, muscle strength, proprioceptive ability and other aspects after acl rupture, as well as the effects of knee bone mineral density, tendon bone healing, bone tunnel aperture, motor function, gait characteristics and cartilage degradation after reconstruction.

Eligibility criteria:
inclusion criteria: 1. age 18\~40 years old, diagnosed acl rupture by mri; 2. the first unilateral acl rupture requires reconstruction at our hospital; 3. greater than 6 weeks from trauma and within 6 months. exclusion criteria: 1. be older than 40 years, or less than 18 years old 2. within 8 weeks of the onset of the trauma, or more than 1 year 3. severe injury to other knee ligaments 4. history of knee trauma
evaluation of the analgesy with emla and/or nitrous oxide in pediatric patients for lumbar puncture

Conditions: Leukemia; Non Hodgkin Lymphoma

Summary: in this randomised controlled study the investigators intended to compare the analgesic effects of emla and\\or nitrous oxide in children submitted to lumbar puncture.

it is a randomized controlled clinical trial, double blinded, with the purpose to compare the use of emla - local anesthetic (lidocaine and prilocaine), and or nitrous oxide at 50% in oxygen (livopan®) to prevent and treat pain in pediatric patients aged four to 16 years old submitted to lumbar puncture for intrathecal chemotherapy. pain was assessed using the wong baker faces scale and the visual numeric scale during six observational periods: baseline; three minutes after gas administration and before the first attempt of lumbar puncture; during the first lumbar puncture attempt; during the chemotherapy administration; during needle remove and three minutes after gas interruption. all the studied procedures will have clinical indication and will not be held by the researcher. the children was random divided within three groups a, b and c as follow: group a (n=16)emla + livopan; group b (n=19)emla + gas placebo (oxygen); group c (n=17) livopan® + placebo cream. primary outcome was the detection of a difference of 20% or more in the visual numeric scale between the three treatment groups during the first attempt of lumbar puncture.

Eligibility criteria:
inclusion criteria: * age between four and 14 years; * not present cognitive disabilities; * necessity to perform the clinical procedure; * accordance in participating in the study. exclusion criteria: * continuity skin lesion in the procedure site; * metahemoglobinemia; * neuromuscular disability; * presence of pneumothorax, emphysema, intra-abdominal infection, cranioencephalic traumatism, otitis media, sinusitis and intracranial hypertension; * vitamin b12 known deficits; * urgency for the procedure; * disagreement in participating of the project; * patients in use of dapsone.

Keywords: lumbar punction myelogram pain assessment nitrous oxide and emla leukemia and non hodgkin lymphoma
effect of different peep values on gastric residual volume

Conditions: Respiratory Aspiration of Gastric Content

Summary: the aim of this study was to predict the effect of gastric antrum diameter before extubation on intra-abdominal pressure changes and consequently on the risk of pulmonary aspiration in patients undergoing elective spinal surgery under general anaesthesia in the prone position in the neurosurgery operating theatre of the ministry of health ankara city hospital and to take precautions accordingly. gastric antrum diameter and intraabdominal pressure measurements may contribute to the improvement of anaesthetic practice by reducing the risk of pulmonary aspiration and additional complications.

prone positioning in spinal surgery is a very important issue for anaesthetists. although there are many conditions that are taken into consideration in patient follow-up, it is a position frequently used in the treatment of pulmonary diseases other than surgery. peep application in the prone position is especially used in the treatment of conditions such as acute respiratory distress syndrome (ards). this treatment method basically aims to improve oxygenation and ventilation in the lungs. while providing improvement in the lungs, it may indirectly lead to some changes in the gastrointestinal system. depending on peep levels, intra-abdominal pressure may increase and subsequently cause reflux of gastric contents or gastroparesis. the prone position itself also increases the risk of reflux. gastric pocus (point of care ultrasound) is a noninvasive method that gives us information about the stomach contents and can be easily performed at the bedside. both patient position and respiratory parameters, such as peep, may have an effect on gastric pocus. visualization of gastric content or detection of gastric retention allows us to predict possible pulmonary aspiration complications before extubation, and gastric pocus may be a valuable marker before extubation in patients who remain in prone positions for a long time. the aim of this study was to determine the effect of peep application on the antrum diameter evaluated by gastric pocus and the risk of aspiration before extubation in patients undergoing spinal surgery in the prone position.

Eligibility criteria:
inclusion criteria * 18-65 years of age * asa i-ii risk group exclusion criteria: * asthma * copd * gastroesophageal reflux * gastric herniation * gastric surgery, * intracranial tumor * epilepsy * neuromuscular disease

Keywords: prone position gastric pocus (point of care ultrasound) antrum diameter risk of pulmonary aspiration different peep levels
to investigate the use of a new syringe "visual pressure control (vpc)" for epidural anesthesia in children surgery

Conditions: Abdominal Hernia; Abdominal Wall Defect; Abdominal Neoplasm; Urogenital Disease; Urologic Neoplasms; Thoracic Diseases; Lung Diseases

Summary: pediatric epidural anesthesia has emerged as a safe and effective regional anesthesia technique for providing intraoperative and postoperative analgesia in thoracic and abdominal surgery. the loss of resistance technique is the gold standard for the placement of the epidural. the vpc (visual pressure control) syringes developed by pajunk enable direct visualization of the introduction of the needle into the epidural space.

this trial is a non blinded, pilot study. a minimum of 15 children between the ages of 0 and 16 who require surgery that may benefit from epidural anesthesia will be enrolled. the number of attempts, the complications (dural and vascular punctures, neurological complications) and the degree of satisfaction of the operator measured by a 7-point likert scale will be studied as secondary objectives.

Eligibility criteria:
inclusion criteria: * children aged from 0 to 16y * surgical procedure that can benefit from a lumbar or low thoracic epidural anesthesia exclusion criteria: * parental refusal * allergy to local anesthetics * coagulation disorders * spine abnormalities
pet/mri imaging of neuraxial inflammation in sciatica patients

Conditions: Sciatica

Summary: the purpose of this study is to see if the spine shows areas of inflammation using a specific type of imaging (pictures).

the purpose of this study is to determine if inflammation around the spinal nerves can be identified using a radioactive tracer \[11c\] pbr28 and integrated pet/mri scan for the purpose of better treating patients who have radicular lumbar pain with epidural steroid injections.

Eligibility criteria:
inclusion criteria for pain subjects: 1. subject is 18-75 years old. 2. subject is able to give written informed consent. 3. subject is currently diagnosed with lower extremity radicular pain regardless of specific or suspected etiologies. 4. subject has a clear dermatomal distribution of the painful area extending to the distal lower extremities. 5. subject reports ongoing pain intensity of 4 or greater using the visual analogue scale (vas) during the week prior to enrollment. inclusion criteria for healthy subjects: 1. subject is 18-75 years old. 2. subject is able to give written informed consent. 3. subject has no history of chronic back/spine pain. exclusion criteria for all groups: 1. subject recently received a lumbar esi (within 8 weeks). 2. subject starts new nsaid medication for pain during the study. 3. subject has predominantly axial low back pain. 4. subject has known pain condition secondary to hip joint arthritis. 5. subject is pregnant or breastfeeding. 6. subject has allergy to lidocaine. 7. subject is treated with chronic corticosteroid therapy. 8. subject is on anticoagulation therapy (i.e. coumadin, plavix, or lovenox). 9. subject has a known bleeding disorder (i.e. hemophilia). 10. subject has uncontrolled high blood pressure \[\>170/100\]. 11. subject has a known heart condition. 12. subject has known inflammatory disease (i.e. inflammatory bowel disease; ankylosing spondylitis; etc.). 13. subject has known liver dysfunction or renal insufficiency or impaired elimination (renal dysfunction is defined as egfr \< 60. hepatic dysfunction is defined as lfts ≥ 3x uln). 14. subject has been hospitalized recently (within one month) for a major psychiatric disorder (i.e. major depression, bipolar disorder, schizophrenia, anxiety disorder, or psychosis). 15. subject has contraindications to mri and pet scanning (i.e. presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, or claustrophobia). 16. subject had research-related radiation exposure in the last 12 months. 17. subject tests positive for use of illicit drugs, marijuana, or non-prescribed drugs.

Keywords: sciatica pet scan mri inflammation epidural steroid injection (esi)
exercise training for reducing anxiety in first-time inmates

Conditions: Anxiety State

Summary: clinical trial with 2 arms ("interval exercise training" or "waiting list") aiming at evaluating the anxiolytic effects of a 6 weeks-long exercise training program in first-time prisoners with elevated anxiety symtpoms


Eligibility criteria:
inclusion criteria: * first-time prisoners ; elevated state anxiety (\> 40 on the state anxiety inventory) exclusion criteria: * symptoms of and/or known cardiovascular, metabolic, psychiatric, neurological or neurodevelopmental disease
survey on the effect of health related quality of life (qol) associated with compliance of carbocisteine in asthma patients

Conditions: Asthma

Summary: the objectives of this study are to investigate the influence on hr-qol (sf-36 v2) resulting from the compliance of mucodyne tablets or mucodyne ds (dry syrup) 50% in asthma patients whose control levels are partly controlled or uncontrolled.

period: 2012-2013 observation time: 0 week, 4 week matters investigated: 1. qol determination using sf-36 v2 2. medication compliance (vas scale) 3. gender, age, diagnosis, asthma subtype, severity, duration of disease, level of asthma control, concomitant drugs, comorbidities, smoking, alcohol, work

Eligibility criteria:
inclusion criteria: * male and female patients ≥ 20 years of age * outpatients * patients with mild or moderate persistent asthma * patients with phlegm * patients whose levels of asthma control are partly controlled or uncontrolled * patients who are planned to treat mucodyne * patients who voluntarily submitted written consent forms upon participation in this study exclusion criteria: * patients with a history of adverse reactions to carbocisteine * patients with serious cardiac, hepatic, renal, pulmonary, or hematological disease * patients with the possibility of pregnancy or suspected pregnancy * patients with complication of malignancy * current smoker * patients with definitive diagnosis for copd * other patients whom investigators or subinvestigators considered inappropriate to participate in this study

Keywords: asthma sf-36 hrqol
transanal reinforcement of low rectal anastomosis in rectal cancer surgery

Conditions: Rectal Cancer

Summary: anastomotic leak after low rectal cancer surgery occurs between 3 and 24% of the cases and is a severe complication leading to sepsis, permanent colostomy, higher risk of local cancer recurrence and eventually death. in order to prevent this complication a protecting diverting stoma is usually fashioned with consequent morbidity due to the stoma and its closure and severe impact on patients' quality of life. this prospective, multi-center, parallel-arm, randomized controlled equivalence trial is aimed to demonstrate whether a transanal reinforcement of the suture line can prevent anastomotic leakage after low rectal cancer surgery thus avoiding the need for a covering ileostomy


Eligibility criteria:
inclusion criteria: * resectable, histologically proven primary adenocarcinoma of the medium-low rectum without internal and/or external sphincter muscle involvement. distal margin of the tumor at least 6 cm form the anal verge staged as follows prior to neoadjuvant chemoradiation: stage t2 - t4 at mri n0-2 at mri m0/m1 at ct scan patient classified t3-t4 must undergo neoadjuvant chemoradiation with at least 8 weeks delay of surgery exclusion criteria: * squamous cell carcinoma * adenocarcinoma stage t1, * t4 with one of the following: with pelvic side wall involvement requiring sacrectomy requiring prostatectomy (partial or total) * unresectable primary rectal cancer or inability to complete r0 resection. * rectal cancer under 6 cm from the anal verge requiring colo-anal anastomosis * recurrent rectal cancer * previous pelvic malignancy * inability to sign informed consent * pregnancy

Keywords: colorectal anastomosis anastomotic leak ileostomy complications
role of macrophage migration inhibitory factor (mif) in heart failure

Conditions: Heart Diseases

Summary: evaluating the additional value of macrophage migration inhibitory factor (mif) in cardiovascular diseases when assessed in clinical routine.


Eligibility criteria:
inclusion criteria: all patients presenting with symptoms of heart failure to the west-german heart and vascular center according to the definition of the esc 2016. * patients fulfilling criteria for the diagnosis of hfref * patients fulfilling criteria for the diagnosis of hfpef * patients fulfilling criteria for the diagnosis of hfmref * patients presenting with dyspnea according to the nyha classification i-iv, elevated bnp/nt-probnp levels and echocardiographic findings of heart failure. exclusion criteria: * age \< 18 years * patients with symptoms of heart failure without fulfilling the criteria of the esc guidelines 2016 * denial to participate