Kornimate/medical-research-clean huggingface dataset:
rct of pep program to reduce acl injuries in female collegiate soccer players

Conditions: Anterior Cruciate Ligament Rupture

Summary: this research study involves implementing and evaluating a physical training program specifically designed to reduce the risk of ligamentous knee injuries in female soccer players by incorporating proven neuromuscular and proprioceptive training concepts into a concise, on-field warm-up activity. all 283 division i ncaa women's soccer teams were asked to participate in this research study. those that agreed were randomized to control (usual training program) and intervention (alternative warm-up program). both groups of teams provided investigators with participation and knee injury information during the 15 week 2002 fall soccer season. requested information included only that which would be readily available to the certified athletic trainers (atc) in their normal course of duties. the knee injury rates among intervention team athletes were compared with control team athletes to determine program effectiveness. data collection is complete and the report should be submitted shortly for publication.

this research study involves implementing and evaluating a physical training program specifically designed to reduce the risk of ligamentous knee injuries in female soccer players by incorporating proven neuromuscular and proprioceptive training concepts into a concise, on-field warm-up activity. all 283 division i ncaa women's soccer teams were asked to participate in this research study. those that agreed were randomized to control (usual training program) and intervention (alternative warm-up program). both groups of teams provided investigators with participation and knee injury information during the 15 week 2002 fall soccer season. requested information included only that which would be readily available to the certified athletic trainers (atc) in their normal course of duties. the knee injury rates among intervention team athletes were compared with control team athletes to determine program effectiveness. data collection is complete and the report should be submitted shortly for publication.

Eligibility criteria:
inclusion criteria: * female soccer athlete on participating division i women's soccer team exclusion criteria: * none
activity pacing for fatigue management

Conditions: Fatigue; Chronic Condition; Self-regulation; Physical Activity; Activity Pacing

Summary: this project will focus on perceived fatigue as a barrier to physical activity participation and will explore if and how activity pacing, fatigue management, and self-regulation strategies can help to overcome this barrier in adults with chronic conditions who experience fatigue symptoms. the main aims are: 1. to demonstrate the differences and similarities on activity pacing, perceived fatigue, self-regulation, physical activity, and health-related quality of life in adults who experience fatigue by comparing individuals who have been through an activity pacing program or not. 2. to explore thoughts, experiences, needs, and perspectives on activity pacing of adults with fatigue and health professionals as well as any ideas for future development of an optimal intervention. participants will be invited to complete questionnaires on several variables (activity pacing, physical activity, fatigue, health-related quality of life, and self-regulation of physical activity). in addition, they will be invited to wear an actigraph for 7 full days and they will also be invited to a focus group interview.

activity pacing is a fatigue management strategy that regulates energy and activity levels while maintaining or increasing engagement in physical activity. this approach is particularly beneficial for individuals with chronic conditions who experience significant fatigue as they often struggle with sustained physical activity participation due to recurring patterns of overexertion and subsequent fatigue or pain. therefore, activity pacing strategies are important because individuals learn to manage fatigue symptoms, optimize physical activity behaviour, and accomplish a more stable activity pacing pattern, which will improve their health-related quality of life and well-being.

Eligibility criteria:
inclusion criteria: * diagnosed with a chronic condition * experience fatigue * ambulatory exclusion criteria: * children * wheelchair users

Keywords: physical activity behavior self-regulation fatigue chronic condition
a study to prevent infantile spasms relapse

Conditions: Infantile Spasms; Infantile Epileptic Spasms Syndrome; West Syndrome

Summary: after initially successful treatment, many children with infantile spasms unfortunately have a relapse, and relapse is linked to poor long-term outcomes such as autism and other forms of epilepsy. the aim of this study is to determine if treatment with low-dose prednisolone is safe, well tolerated, and effective in reducing the risk of relapse.

in this study, the investigators will enroll infants who have responded to standard therapy for treatment of infantile epileptic spasms syndrome (iess). patients will be randomized to receive either low-dose prednsiolone or placebo for 4 months. during the first 7 months, patients will be evaluated monthly, with clinic visits and electroencephalography (eeg). patients will then return for a final visit at age 2 years. key outcomes will be determination of iess relapse, emergence of other types of seizures/epilepsy, and evaluation of developmental/behavioral status at age 2 years. we will attempt to determine whether or not the prednisolone intervention reduces the risk of any adverse outcome, but this may not be possible given the study design. we will also evaluate the feasibility of the intervention, study procedures, and recruitment.

Eligibility criteria:
inclusion criteria: 1. age 2 to 18 months, inclusive 2. clinical diagnosis of infantile spasms syndrome, with eeg-confirmed complete response to standard treatment (prednisolone, acth, and/or vigabatrin) exclusion criteria: 1. presence of clinically significant hypertension, infection, or any other diagnosis which poses unreasonable risk in the setting of extended corticosteroid therapy, in the view of the study physician 2. exposure to any artisanal cannabinoid product within 14 days of screening 3. ongoing therapy with the ketogenic diet 4. implantation of a vagal nerve stimulator within 3 months of screening, or any change in stimulation parameters within 1 month of screening 5. treatment of iess via epilepsy surgery

Keywords: relapse infantile spasms prednisolone
efficacy combined fecal immunochemical test-sigmoidoscopy for the detection of advanced colorectal neoplasia

Conditions: Colorectal Adenoma

Summary: the purpose of this study is to evaluate the efficacy and cost-effectiveness of fecal immunochemical test combined with sigmoidoscopy (fits) for the detection of advanced colorectal neoplasia compared to colonoscopy.

the investigators will evaluate the efficacy of fits for the detection of advanced colorectal neoplasia compared to colonoscopy. this study was designed as multicenter randomized interventional study. the expected period are 36months. a total 13 tertiary hospitals will participate in the study. subjects will be randomly allocated to fits group and colonoscopy group. subjects who undergo fits will be performed by following colonoscopy to confirm the efficacy of fits. in colonoscopy group, subjects as a control group would be performed colonoscopy.

Eligibility criteria:
inclusion criteria: * asymptomatic subjects aged 45 - 75 years * subjects who will give the written consent exclusion criteria: * subjects with past history of colorectal cancer * subjects with familial histories of familial adenomatous polyposis(fap) or hereditary nonpolyposis colorectal cancer(hnpcc) * subjects with familial history of colorectal cancer more than 2 familial member in direct line * subjects with inflammatory bowel disease(ibd) * subjects with more than 3 point of american society of anesthesiologists (asa) physical classification * subjects with past history of colectomy * subjects with history of colonoscopy within 5 years * subjects with history of sigmoidoscopy within 3 years * subjects with history of ct colonoscopy within 10 years * subjects with symptoms that could present the colorectal cancer such as hematochezia, melena, weight loss more than 10kg/6months

Keywords: advanced colorectal adenoma colonoscopy sigmoidoscopy fecal immunochemical test
validation/evaluation of multimodal imaging combining 3d ultrasound and stress myocardial scintigraphy in the diagnosis of coronary artery disease

Conditions: Coronary Artery Disease; Coronary Disease

Summary: our primary goal is to validate a new diagnostic tool for functional coronary artery stenosis that uses multimodal imaging (combining stress echocardiography and stress scintigraphy) in patients with known coronary chest pain.


Eligibility criteria:
inclusion criteria: * the patient must have given his/her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * the patient has a documented coronaropathy * the patient needs a new coronarography following symptoms indicating a change in his/her coronary disease state exclusion criteria: * the patient is participating in another study * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * the patient refuses to sign the consent * it is impossible to correctly inform the patient * the patient is pregnant * the patient is breastfeeding * patients with arrhythmias, left bundle branch block on the electrocardiogram which would complicate the interpretation of examinations * unstable, acute coronary syndromes unstable needing emergency coronary angiography * patient with contraindication for conducting a stress test: * poorly controlled hypertension * pre-existing severe arrhythmia * aortic stenosis * and obstructive hypertrophic cardiomyopathy * patient has contraindication for atropine * history of prostate adenoma * glaucoma
a pilot study of the efficacy of recombinant alpha interferon (ifn-a2b) and zidovudine (azt) in the treatment of progressive multifocal leukoencephalopathy (pml) complicating hiv-1 infection

Conditions: HIV Infections; Leukoencephalopathy, Progressive Multifocal

Summary: to study the effectiveness of alpha interferon (ifn-a2b) and zidovudine (azt) in treating progressive multifocal leukoencephalopathy (pml) as a complication of hiv-1 infection.


Eligibility criteria:
inclusion criteria patients must have: * hiv seropositivity by both elisa and western blot. * biopsy proven progressive multifocal leukoencephalopathy (pml). exclusion criteria co-existing condition: patients with the following conditions or symptoms are excluded: * intolerant to interferon. * prior or concomitant central nervous system disease (cns) such as toxoplasmosis, multiple sclerosis (ms), or neurosyphilis. patients with the following are excluded: * intolerant to interferon. * prior or concomitant central nervous system disease (cns) such as toxoplasmosis, multiple sclerosis (ms), or neurosyphilis. prior medication: excluded: * patients receiving interferon for other reasons.

Keywords: leukoencephalopathy, progressive multifocal interferon alfa-2b drug evaluation acquired immunodeficiency syndrome zidovudine
evaluation of non-b non-c liver cirrhosis in a el-rajhi assuit university hospital: a retrospective-prospective study

Conditions: Non-B Non-C Liver Cirrhosis

Summary: to study the etiologies of patients diagnosed as non-b, non-c liver cirrhosis (nbnc-lc). to describe the different patient's outcomes.

liver cirrhosis is the ultimate fate of many hepatic insults that may be viral, immunologic, and metabolic or even cryptogenic. (tsochatzis ea et al., 2014) recently, non-alcoholic fatty liver disease (nafld) present a serious health burden worldwide that affects around 25% of the global adult population with a prevalence of around 31.8% in the middle east. (younossi zm, et al., 2019) most of egyptian patients presented with end-stage liver disease are secondary to post-hepatitic cirrhosis is estimated to be more than 80% of cases. (guerra j et al., 2012) the real profile of non-b, non-c etiologies of liver cirrhosis, in egyptian patients, is still not fully evaluated.

Eligibility criteria:
inclusion criteria: * all pateints diagnosed as non-b non-c liver cirrhosis in the period from 2017_2023 exclusion criteria: * we will exclude the pateints that will be diagnosed as hbv-hcv induced liver cirrosis
hypotension prediction index vs norepinephrine infusion for prevention of spinal hypotension for cesarean delivery

Conditions: Hypotension During Surgery; Hypotension Drug-Induced

Summary: the goal of this randomized controlled trial is to compare for non inferiority for fetal wellbeing hypotension prediction index - guided therapy and continuous norepinephrine infusion in in the prevention of spinal anesthesia-induced hypotension for cesarean delivery. the main question it aims to answer are: • are fetal arterial base excess comparable with the two treatments? participants will undergo continuous noninvasive hemodynamic monitoring with advanced hypotension prediction index researchers will compare with patients receiving continuous norepinephrine infusion and standard blood pressure monitoring with arm cuff.

in the hypotension prediction index group, patients will be monitored continuously with a noninvasive hemodynamic device. the hypotension prediction index is a number based on al algorithm that predicts impeding hypotension if it is greater than 85. in the treatment group, patients will be treated with norepinephrine boluses if the hypotension prediction index is \>85. in the control group patients will be treated with preventive continuous infusion of norepinephrine and blood pressure will be measured noninvasively every minute. data about blood pressure and the vasopressive treatment will start concomitantly to the administration of spinal anesthesia and will stop after delivery. blood gas samples will be then collected from the placental umbilical artery to compare fetal arterial base excess as primary outcome for non-inferiority.

Eligibility criteria:
inclusion criteria: * pregnant women between the 36th and the 40th week of gestation undergoing spinal anesthesia for elective caesarian delivery. exclusion criteria: * preeclampsia; * eclampsia; * atrial fibrillation and sinus tachycardia; * cardiovascular diseases; * neuromuscular disease; * emergent or urgent cesarean delivery; * coagulopathies; * contraindications to spinal anesthesia.
the role of music therapy in improving college students' mental health and self-efficacy

Conditions: Depressive Symptoms; Anxiety Symptoms; Stress Symptoms

Summary: interventional trial (randomized experimental design) study goal: this clinical trial aims to evaluate the effectiveness of a structured music therapy program in improving mental health (depression, anxiety, stress) and self-efficacy among college students. key questions the study aims to answer: does music therapy significantly reduce symptoms of depression, anxiety, and stress in college students? does music therapy significantly enhance self-efficacy in college students? how do improvements in mental health relate to changes in self-efficacy? study design: researchers will compare outcomes between two groups: experimental group: receives a 2-week daily music therapy intervention (1 hour per session) in a controlled environment. control group: does not receive any music therapy intervention during the study period. participant activities: complete pre- and post-intervention assessments using validated scales: depression-anxiety-stress scale (dass-21) to measure mental health status. self-efficacy scale to evaluate confidence in personal capabilities. experimental group participants will: engage in daily music therapy sessions featuring rhythmically smooth and soothing music selected to promote relaxation. experience the intervention in a quiet, controlled environment. control group participants will: continue their regular routines without any therapeutic intervention. all participants will submit responses via electronic questionnaires (wenjuanxing platform) to ensure efficient and accurate data collection. duration: intervention period: 2 weeks. data collection: pre-intervention baseline assessment, immediate post-intervention assessment.


Eligibility criteria:
inclusion criteria: 1. participants must be current undergraduate students (from freshmen to seniors), primarily aged between 18 and 25 years old (based on the actual age distribution of the sample). 2. written informed consent was obtained from all participants prior to their involvement in the study. 3. participants' baseline mental health status was not excluded (the study did not set strict clinical diagnostic criteria), but they must be able to cooperate with the intervention and complete questionnaires. exclusion criteria: 1.participants who are unable to fully participate in the 2-week intervention (such as dropping out midway or taking leave) or who do not complete the pre- and post-intervention questionnaires will be excluded.
quality-of-life management for copd patients

Conditions: Copd; Chronic Respiratory Disease

Summary: the investigators aim to investigate the effects of a telemonitoring and chatbot-based application of "living well with copd" (cair) on health-related quality-of-life in patients with copd.

the disease management programme "living well with copd" was developed to relieve symptoms and prevent exacerbations. it covers a disease self-management approach, educational topics, lifestyle coaching and physical activity advice. future implications should aim to make the intervention easily accessible for a broad spectrum of patients at scalable costs. patients need an engaging communication platform which can inform, coach and even listen in between medical visits. the inclusion of a chatbot agent may provide this tailored feedback. the investogator's aim is to investigate the effects of a telemonitoring and chatbot-based application of "living well with copd" on health-related quality-of-life in patients with copd.

Eligibility criteria:
inclusion criteria: • diagnosed copd according to gold-guidelines exclusion criteria: * physical or intellectual impairment precluding informed consent or protocol adherence * non-german speaking * acute or recent (within the last 6 weeks) exacerbation of copd * attending a pulmonary rehabilitation program within the last 3 months * pregnant patients

Keywords: telemonitoring chatbot multimodal intervention
sinus tarsi versus extensile lateral approach for calcaneus fractures

Conditions: Intra-articular Fractures

Summary: this study is a prospective, randomized controlled trial comparing the sinus tarsi approach to the extensile lateral approach for surgical fixation of calcaneus fractures. it is hypothesized that open reduction and internal fixation of intra-articular calcaneus fractures using a sinus tarsi approach will provide equivalent fracture reduction and stable fixation with significantly decreased wound complication rates in comparison to an extensile lateral approach.


Eligibility criteria:
inclusion criteria: * skeletally mature patients ≥ 18 years of age * closed intra-articular calcaneus fractures * undergoing surgical fixation (cpt code 28415) * ability to understand and agree to informed consent exclusion criteria: * patients \< 18 years of age * open fractures * dislocations that require open reduction * previous calcaneus abnormality or injury * unable to understand or agree to informed consent

Keywords: calcaneus fracture fixation, internal
vitamin d3 supplementation for heart failure patients

Conditions: Heart Failure; Vitamin D Deficiency; Cardiomyopathy; Congestive Heart Failure

Summary: the purpose of this study is to determine if treatment with vitamin d3 of 10,000 international units (iu) daily in vitamin d deficient patients for 6 months will improve b type natriuretic peptide (bnp), a marker of heart function, compared to placebo. the investigators also aim to determine if vitamin d helps cardiopulmonary function as evaluated by cardiopulmonary exercise test (cpx), laboratory values, strength, and quality of life in patients with stable congestive heart failure (class ii or iii).


Eligibility criteria:
inclusion criteria: * nyha heart failure class ii or ii, stable * vitamin d deficiency (32 ng/ml or less) * no recent medication changes for 3 months * females of childbearing age must use effective contraceptive if they are sexually active exclusion criteria: * hypercalcemia * nephrolithiases * sarcoidosis * acute cardiac insufficiency * pregnancy * breastfeeding * any clinically unstable medical condition * supplements of greater than or equal to 1000 units of vitamin d per day

Keywords: vitamin d cholecalciferol heart failure congestive heart failure cardiomyopathy strength parathyroid hormone calcium quality of life c reactive protein cardiopulmonary exercise testing prognosis
a pilot trial of perinatal depression treatment in hiv infected women

Conditions: Perinatal Depression; HIV-1-infection

Summary: this pilot study will evaluate, through quantitative and qualitative methods, whether different treatments for postpartum depression are feasible and acceptable in postpartum hiv infected women on antiretrovirals (art). the study will take place at several clinics in lusaka, zambia.

the standard of care for treating postpartum depression in the us is antidepressants, psychotherapy or both. little data exist on the best method for treating perinatal depression (pnd) in sub-saharan africa. this is a mixed method study including a pilot randomized controlled trial (rct) of antidepressant medication (adm) versus interpersonal psychotherapy (ipt) and qualitative semi-structured interviews (ssis). the study will enroll 100 pregnant hiv infected women over the age of 18 seeking postnatal care and continuing antiretroviral therapy in pregnancy. an additional 20 women enrolled in the rct will be invited to participate in ssis. each participant will be followed for 24 weeks.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * documentation of confirmed hiv-1 infection * six to eight weeks postpartum * currently taking art treatment * able and willing to provide written informed consent * willing to adhere to study visit schedule * pnd diagnosis confirmed by mini-international neuropsychiatric interview exclusion criteria: * taking an adm in the prior 12 months prior to enrollment * actively suicidal * known or suspected allergy or contraindication to first line sertraline * any other condition (social or medical) which, in the opinion of the study staff, would make trial participation unsafe or complicate data interpretation.

Keywords: perinatal depression hiv antiretroviral treatment interpersonal psychotherapy