Kornimate/medical-research-clean huggingface dataset:
effects of lactobacillus coryniformis cect5711 on immune response to influenza vaccination in adults over 65.

Conditions: Influenza Vaccination; Immune Response; Probiotics

Summary: the objective of the present study is to evaluate the capability of the probiotic strain lactobacillus coryniformis k8 cect5711 (lc k8) to enhance the immune response to influenza vaccine in elderly and the effect on respiratory symptoms related to respiratory infections. a randomized, double-blind, placebo-controlled trial was conducted between november of 2015 and april of 2016. a total of 98 residents of nursing homes aged more than 65 years were randomly assigned to receive lc k8 or placebo for two weeks previous to influenza vaccination. primary outcome was the percentage of seroconversion. secondary outcome were the incidence of influenza-like illness and respiratory symptoms associated to respiratory infections during the follow-up period of 5 months. serum cytokines and immunoglobulins levels were also evaluated.

the objective of the present study is to evaluate the capability of lc k8 to enhance the immune response to influenza vaccine in elderly and the effect on respiratory symptoms related to respiratory infections. a randomized, double-blinded, placebo controlled, multicenter trial was performed. the study was started on october 2015 and ended on april 2016. the recruitment of volunteers was carried out in five nursing home of granada (spain) at the beginning of the vaccination program. volunteers were randomly assigned to one of two groups. those in the placebo group daily consumed a capsule containing 300 mg of maltodextrin. those in the probiotic group daily consumed a capsule containing 3x10(9) colon-forming units of the strain lc k8 in a matrix of maltodextrin. from two weeks previous to the beginning of the intervention the consumption of any probiotic supplement was restricted until the end of the study. during two weeks before flu vaccination volunteers daily received a capsule of probiotic or placebo. day 15 of the study all volunteers received intramuscular vaccination against flu (inactivated trivalent influenza: a/california/7/22009\[h1n1\]pdm09, a/hongkong/4801/2014\[h3n2\], b/brisbane/60/2002) for the vaccine campaign of 2015/2016 (sanofi pasteur europe, lyon, france). all volunteers were vaccinated during the same week (second week of november 2015). after vaccination volunteer were followed-up until 31 of april 2016.

Eligibility criteria:
inclusion criteria: * residents in nursing home aged more than 65 years exclusion criteria: * frequent gastrointestinal diseases, antibiotic treatment during the intervention, allergy to any groups of antibiotics, egg proteins or adjuvants and excipients of the flu vaccine

Keywords: lactobacillus coryniformis flu vaccine
brief virtual mindfulness-based group intervention with social support for perinatal individuals

Conditions: Substance Use; Pregnancy Related; Mental Health

Summary: this is a feasibility and acceptability study for 4- week virtual mindfulness-based intervention with social support for perinatal individuals at higher risk for substance use. this study builds on the longitudinal collection of questionnaire data from pregnant and postpartum people during the covid-19 pandemic. each closed virtual support group will meet weekly for 4 weeks using a video conference platform. groups will be focused on grounding, thinking patterns, self-compassion and self-care. this approach will foster increase awareness of wellbeing as well as social support between group participants. primary outcomes include the feasibility and acceptability of this group-based intervention for perinatal individuals.


Eligibility criteria:
inclusion criteria: * currently pregnant * have a single gestation pregnancy * fluently speak english * a history of significant substance use or currently in treatment for a substance use disorder. exclusion criteria: * inability to provide consent
botulinum toxin to improve cosmesis of primary cleft lip repair

Conditions: Cleft Lip; Scarring; Cleft Palate

Summary: objective: to determine if the use of botulinum toxin during primary cleft lip repair improves the cosmetic appearance of the cleft lip scar


Eligibility criteria:
inclusion criteria: * complete unilateral cleft lip with or without cleft palate * planned for a primary cleft lip repair exclusion criteria: -bilateral cleft lip

Keywords: botulinum toxin botox craniofacial deformity
evaluation of the absorption rate from different oral fe-supplements in obese volunteers pre- and post-rygb

Conditions: Obesity

Summary: obese volunteers who have scheduled a gastric bypass (rygb) in uz leuven will be asked to participate in a cross-over study using commercial available iron supplements. the aim of this study is to evaluate the absorption rate of different oral iron supplements in volunteers before and after rygb (1, 3, 6 and 12 months post-rygb).

patients who met the criteria will be invited to come to the clinical research center at 10 occasions (two times before and 1, 3, 6 and 12 months after rygb). during each visit the following information will be collected: * general information concerning sociodemographic and medical background * the medical history * anthropometric measures * physical activity by questionnaire * food frequency by questionnaire * information about menstrual blood loss. following an overnight fast, subjects will come to the clinical research center. an intravenous catheter will be inserted to collect blood samples. before the oral administration, blood samples will be collected for the determination of the serum concentration of different iron status markers. the volunteers will receive first an iron(ii)sulfate supplement, followed by a fe-chelate supplement (at least 7 days between both supplements). after the administration of the supplement, blood samples will be taken at various time points to determine the amount of iron absorption and to investigate if there are any changes in the iron metabolism (at 15, 30, 60, 90 minutes and 2; 2.5; 3; 3.5; 4 and 5 hours after oral administration). there will be a one-week washout period between the tests with each iron supplement. the volunteers will be asked to repeat the test before surgery and 1, 3, 6 and 12 months after surgery for each iron supplement.

Eligibility criteria:
inclusion criteria: * obese patients who have planned a rygb surgery in the university hospital leuven * low iron status at the preoperative consultation (ferritin \< 30 µg/l and/or transferrin saturation \<20%) exclusion criteria: * patients with a bariatric surgery history * smokers (\> 15 cigarettes/day) * pregnant women * lactating women * patients with a positive helicobacter pylori screening
interest of thromboelastography (rotem) as a biomarker of revascularisation in stroke

Conditions: Stroke

Summary: revascularisation using recombinant tpa is the reference treatment of stroke. however, the efficacy of fibrinolysis is about 50%. several factors, including the size of thrombus, have been associated with revascularisation efficacy. the aim of this prospective study is to evaluate ex vivo the effect of tpa in patients with stroke with thromboelastography and to correlate results with the clinical outcome of patients. results may predict revascularisation in patients with stroke.


Eligibility criteria:
inclusion criteria: * patient (\> 18 years) with a neurological deficit compatible with a neurovascular pathology eligible for fibrinolysis rtpa and having a proximal occlusion of the middle cerebral artery (segment m1 / m2) or basilar trunk objectified brain imaging (mri angiography or angio ct). exclusion criteria: * any patient with major comorbidity, a pathology of hemostasis or anticoagulant treatment (vitamin k antagonist (vka), direct oral anticoagulant).

Keywords: fibrinolysis tpa
the validity and reliability of the turkish version of the cpaq-8

Conditions: Fibromyalgia; Chronic Pain

Summary: acceptance of chronic pain is becoming an increasingly important issue in the field of pain management. many researchers argue that patients who accept pain better function better both physically and psychologically. in many countries, the chronic pain acceptance questionnaire - 8 (cpaq-8) has been frequently validated and used to measure the pain acceptance of patients with chronic pain.1 however, the cpaq-8 has not yet been introduced and validated in turkey. in this study, we aimed to translate the english version of cpaq-8 into turkish, make correct cross-cultural adaptations, and validate the psychometric properties of the turkish version of cpaq-8 by testing it in turkish fibromyalgia patients.

chronic pain is an undesirable condition that affects a large part of the society and increases the psychological and economic burden of the population it affects. psychological variables are known to be strong in the perception of pain and especially cause patients to avoid activity in order to reduce pain. individuals prefer to avoid painful experiences when they are worn out in repetitive attempts to control and prevent pain, which ultimately causes pain to become more dominant and destructive, and activities that are valuable to the individual are neglected.1 at this point, accepting pain can be seen as the antithesis of avoiding painful experiences. acceptance of pain is a strong predictor of low disability in chronic pain.2 the chronic pain acceptance questionnaire (cpaq) represents one of the ways in which pain acceptance is functionalized and measured in the context of chronic pain. the short form of cpaq, cpaq-8, was developed and validated recently and shows the same factor structure, reliability and validity as the 20-factor version. given that psychometric testing is an incremental process, further evaluation of the questionnaire is desirable, including test-retest reliability and replication of results reported by fish et al.

Eligibility criteria:
inclusion criteria: * patients who applied to our physical medicine and rehabilitation outpatient clinic, * agreed to participate in the study, were over the age of 18, * had at least primary school education, were diagnosed with fibromyalgia syndrome according to the 2016 american college of rheumatology (acr) criteria, * could speak and communicate in turkish were included in the study. exclusion criteria: * those who did not agree to participate in the study, * \<18 years old, and could not communicate in turkish
effect of rocuronium on bis values

Conditions: Breast Cancer; General Anaesthesia

Summary: aim of this trial is to define if trend of four (tof) values after a bolus of rocuronium is correlated with bispectral index bis values during standard general anaesthesia for breast surgery.

rocuronium. a curarizing agent, has been shown to decrease bispectral index (bis) in awake volunteers. however, correlation between trend of four (tof) values after a bolus of rocuronium and bis values during general anaesthesia for breast surgery has not been defined yet. investigators want to analyze this correlation during general anaesthesia conducted using propofol and remifentanil. all of these drugs will be delivered with targeted-controlled infusion pumps (in particular eleveld for propofol, minto for remifentanil), commonly used to deliver general anaesthesia. at stable anaesthesia maintenance, if requested for surgical (ie more muscle relaxation) or anesthesiological reasons (i.e. avoid air insufflation) a standard rocuronium bolus (0.6 mg/kg) was given. in these case, with rocuronium bolus justified by clinical reasons, authors will observationally record the bis values and the tof values.

Eligibility criteria:
inclusion criteria: * undergo general anaesthesia with propofol and remifentanil, and necessity of curarization with rocuronium for surgical or ventilatory reasons. exclusion criteria: * neurological disease * psychiatric disease * benzodiazepines praemedication * obesity
expression of programmed death-1 (pd-1) & programmed death ligand-1 (pdl-1) in acute lymphoblastic leukemia in pediatric

Conditions: Acute Lymphoblastic Leukemia in Pediatric

Summary: acute lymphoblastic leukemia (all) is the most common childhood malignancy in the world. it is a malignant clonal proliferation of lymphoid progenitor cells, but most commonly of the b cell lineage (b all). . acute lymphoblastic leukemia (all) is a heterogeneous disease that causes malignant hematological disorders at any age. it mainly affects children aged 2 to 5; in fact, 60% of pediatric leukemia cases are all, with an incidence of 3-4 cases per 100,000 per year. it is divided into two subtypes b-all and t-all depending on whether transformation occurs in b- or t-cell precursors, respectively . leukemic cells apply multiple immune evasion mechanisms resulting in tumor progression. one of the most important immune escape mechanisms is over expression of immune checkpoint receptors and their ligands such as pd-1 and pd-l1 . the pd-1 receptor plays a crucial role in a broad spectrum of immune regulatory mechanisms . it is a negative co-receptor that down regulates t-cell activity . pdl 1, which is known as b7 h1 , is a cell surface protein of b7 family member . pd l1 is expressed on all types of lympho hematopoietic cells at variable levels and is constitutively expressed on t cells, b cells, macrophages, and dendritic cells . tumors exploit the pd-1/pd-l1 pathway to evade host immune surveillance . pd-1/pd-l1 pathway controls the induction and maintenance of immune tolerance within the tumor microenvironment. the activity of pd-1 and its ligands pd-l1 or pd-l2 are responsible for t cell activation, proliferation, and cytotoxic secretion in cancer to produce anti-tumor immune responses .


Eligibility criteria:
inclusion criteria: * age range from 1 day to 18 years old * patients who are newly diagnosed and under treatment of acute lymphoblastic leukemia exclusion criteria: * other types of acute leukemia rather than acute lymphoblastic leukemia
low-dose maximal-intent versus controlled-tempo resistance training on quality-of-life in older adults

Conditions: Quality of Life

Summary: the aims of this study were to: 1. compare the effects of low-dose maximal intent and controlled tempo resistance training on untrained healthy older adults' quality-of-life, functional capacity, and strength. 2. qualitatively explore perceptions of maximal intent and controlled tempo resistance training in older adults. older adults are defined as being 60 or more years of age.


Eligibility criteria:
inclusion criteria: * participants were eligible if they were between 30-60 years old * uninjured * had no cardiovascular or neuromuscular conditions * had not participated in lower-limb resistance training in the previous six months. exclusion criteria: * participants were excluded if they had either taken part in any lower-limb resistance training in the last six months * had underlying health condition(s) that prevented them from participating in resistance training * regularly met or exceeded the uk recommended physical activity guideline of 150-minutes of moderate to intense physical activity per week.

Keywords: activities of daily living balance independence mobility untrained
pilot study of primary and secondary attention-deficit/hyperactivity disorder among survivors of childhood cancer

Conditions: ADHD; Cancer

Summary: this is a pilot study that will be an exploratory investigation of the rate of occurrence of adhd/s-adhd in adolescent cancer survivors. the procedures that will be used for identifying attention problem symptoms, determining the frequency and severity of such symptoms, and characterizing the level of impairment resulting from the symptoms are novel to pediatric oncology research.this pilot study will draw from the approach used in traumatic brain injury research of post-injury effects to illuminate more clearly the nature of attentional late effects experienced by survivors of childhood cancer.

1. this study will investigate the feasibility of assessing symptoms of developmental adhd and "secondary adhd" (s-adhd) among adolescent survivors of childhood cancer using a structured diagnostic clinical interview procedure. (s-adhd describes an acquired clinical presentation that is consistent with the diagnostic criteria of adhd). 2. this study will provide preliminary estimates of the rate of occurrence of adhd/s-adhd among adolescent survivors of childhood cancer as compared to the prevalence of developmental adhd in the general population. 3. the study will examine the relationship between adhd/s-adhd symptoms and laboratory measures traditionally used to assess specific components of attention (e.g., cpt) in survivors of childhood cancer. 4. the study will examine the relationship between adhd/s-adhd symptoms and smoking (including intentions, behaviors, and motivators) among adolescent survivors of childhood cancer.

Eligibility criteria:
inclusion criteria: 1. patients treated for acute lymphoblastic leukemia (all) or primary central nervous system (cns) tumor. 2. completed primary treatment at least one year prior to enrollment with no evidence of active disease. 3. age 12-17 years inclusive at the time of enrollment. 4. at least one parent/guardian must be present. 5. participant and parent are able to understand english. 6. participant and parent are willing and able to provide consent/assent according to institutional guidelines. 7. parent/guardian signs consent. exclusion criteria: 1.significant impairment in intellectual functioning (e.g., full or estimated iq \<70) as documented in the medical record.

Keywords: adhd, childhood cancer adhd/secondary adhd among survivors of childhood cancer
effect of agaricus blazei (murrill) ss. heinemann (sun mushroom)

Conditions: Hepatitis C; Nutritional Status; Hepatitis, Viral, Human

Summary: the aim of the study was to verify the influence of agaricus blazei (murrill) ss. heinemann (a. blazei) on the evolution of nutritional state and liver function in hepatitis c patients.

ten patients were studied (5 - gi - not taking a. blazei - and 5 - g2 - taking a. blazei), from both sexes, with positive anti-vhc and a healthy nutritional state, admitted into in the viral hepatitis ward. diagnosis and treatment for hepatitis c concurred with the regulations of the ministry of health and nutritional evaluation was performed in 3 moments according to anthropometrical, bioimpedance, biochemical and dietary standards, with duration of 6 months. the consumption of a. blazei (10g/day) in dehydrated powder was concomitant with antiviral therapy (conventional or pegylated interferon associated with ribavirin) with duration of 5 months.

Eligibility criteria:
inclusion criteria: * to have been informed and signed adequately the free and clarified assent * initiating the anti-viral treatment (interferon or pegylated interferon associate the ribavirin) * age: 24-70 years * gender :both the gender * race : all races * to present serology positive to the anti-vhc elisa * to present genotype type 1,2,or 3 * body mass index- \>18,5 e \< 35kg /m2 * conditions full to the oral ingestion exclusion criteria: * don't agree to the project or don't have signed the term of clarified free assent * restriction for oral ingestion * the existence of surface of antigen of the hepatitis b virus(ag hbs) * the existence of antibody for the human immunodeficiency virus * to be enclosed in another project of research or form of treatment * pregnant women * suckles * cirrhosis * patients with hepatitis auto-imune.

Keywords: agaricus blazei (murrill) ss. heinemann, hepatitis c nutritional status liver function tests antiviral agents
early rehabilitation using functional electrical stimulation assisted supine cycling in the intensive care unit

Conditions: ICU Acquired Weakness

Summary: critically ill patients in the intensive care unit are known to lose muscle mass and function at a rapid rate. currently, there is a global recognition and shift in the icu culture to reduce sedation and encourage exercise and mobilization early during the icu stay. functional stimulation assisted supine cycling can be applied to patients in the bed and does not require patient participation. this study seeks to evaluate the effect of conventional exercise and early mobilization in combination with functional stimulation assisted supine cycling applied early during the icu on muscle mass, strength, and physical function, as well as patient-reported disability as compared to conventional exercise and early mobilization alone.


Eligibility criteria:
inclusion criteria: * ≥ 18 years of age * admitted to the icu with a predicted icu length of stay ≥ 4 days * expected to survive the icu stay * expected to receive mechanical ventilation \> 48 hours * able to perform physical outcome measures pre-morbidly (with or without an assisted device) exclusion criteria: * proven or suspected neuromuscular weakness affecting the legs (eg- stroke or guillain-barré syndrome) * lower limb amputation(s) * assessed by medical staff as approaching imminent death or withdrawal of medical treatment within 36 hours * pregnancy * body mass index \> 40 * presence of external fixator or superficial metal in lower limb * open wounds or skin abrasions at electrode application points * presence of pacemaker or implanted defibrillator * transferred from another icu after \>48 hours of consecutive mechanical ventilation * lower limb malignancy * pre-existing intellectual disability or cognitive impairment limiting the ability to accurately follow instructions * body habitus unable to fit the bike * palliative goals of care * unable to participate in fesc within 48 hours of icu admission due to logistic reasons or due to failure in daily screening for participation
effectiveness of computerized device new of visual motor simulation versus mirror therapy in hemiplegic patients.

Conditions: Stroke

Summary: mirror therapy (tm) has been shown to be effective in motor rehabilitation of the hemiplegic upper limb, but its implementation in current clinical practice has several difficulties, both from the patient and physiotherapist point of view. a new computerized mirror therapy (tm) device (intensive visual simulation 3 (ivs3), dessintey) which aims to solve the tm compliance problems and make it more efficient have been developed.

the aim of this study is to compare the observance and efficiency of the intensive visual simulation 3 (ivs3) therapy as compared to traditional mirror therapy (tm) in a population of hemiplegic stroke patients.

Eligibility criteria:
inclusion criteria: * first ischemic or hemorrhagic stroke for less than one year * not having reoffend * responsible for an initially complete hemiplegia, * upper-limb deficiency with the modified frenchay score below 70, * not neurological history other than stroke, * having signed the written consent * affiliated or entitled to a social security scheme exclusion criteria: * patient who have not magnetic resonance images (mri) of the brain during stroke * having complete lesion of the primary motor cortex * with an addiction to alcohol or drugs * with psychiatric illness, cognitive impairment, uncontrolled disease / epilepsy, malignancy, severe renal or pulmonary impairment * history of associated disabling general disease * with associated cerebellar syndrome * with clinical involvement of the brainstem * pregnancy in progress * patients under the protection of justice.

Keywords: stroke upper limb rehabilitation computerized mirror therapy hemiparetic mirror therapy