Kornimate/medical-research-clean huggingface dataset:
safety and efficacy study of peripheral blood mononucleated cells for treatment of liver cirrhosis

Conditions: Liver Cirrhosis

Summary: the investigators aim to investigate the safety and efficacy of peripheral blood monocyte for the treatment of patients with advanced liver cirrhosis.

g-colony stimulating factor(5ug/kg/day)will be administered twice subcutaneously for 3 days to three patients with liver cirrhosis. on the day 4th, plasmapheresis will be done to collect peripheral blood mononucleated cells . and then we are going to infuse the collected peripheral blood mononucleated cells of their own through the portal vein of each patients under ultrasonographic guidance.

Eligibility criteria:
inclusion criteria: 1. 20 =\< age \< 80 2. advanced liver cirrhosis with child-pugh score 8 or 9 (including patients who have no radiologic evidence of remnant hcc for more than 2 years after treatment) exclusion criteria: 1. hbsag-positive 2. active status of hepatocellular carcinoma (hcc) (except patients who have no radiologic evidence of remnant hcc for more than 2 years after treatment) 3. history of hemochromatosis and/or autoimmune hepatitis 4. pregnant women or lactating women 5. hemoglobin \< 8g/dl (male), 7.5g/dl (female) or white blood cell (wbc) \<1,500 mm3 or neutrophils \<500/mm3 or platelet count \<50,000/mm3 6. serum creatinine\> 1.5 x normal upper limit or creatinine clearance \<60 ml/min 7. presence of signs of malignant tumors or tumor suspected symptoms, or history of malignant tumors with recurrence rate greater than 20% within two years 8. gastrointestinal bleeding within the last 3 months or if there is a history of spontaneous bacterial peritonitis 9. presence of portal vein thrombosis 10. presence of acute infections
role of inflammation in vascular phenotype associated with e-cigarette use

Conditions: Electronic Cigarette Use; Endothelial Dysfunction; Inflammation

Summary: the use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the united states has increased exponentially since their introduction to the us market in 2007. prevalence of ever and current e-cigarette use is highest among teenagers and young adults with 16-28% of this population having reported vaping. while the majority of e-cigarette users are current tobacco smokers, 32.5% of current e-cigarette users are never- or former-smokers, representing a growing population of young adults who exclusively vape. while e-cigarettes have been marketed as a safer alternative to tobacco cigarettes, clinical studies examining these claims are limited. cardiovascular disease (cvd) is the primary cause of premature death among tobacco cigarette smokers and reductions in vascular endothelial function, a significant predictor of future cvd, are detectible in otherwise healthy young adults who smoke. despite the explosion in e-cigarette use among young adults, the health effects - especially the effects on mechanisms of vascular function - of these devices remain relatively unexplored. the purpose of this study is to directly asses the mechanistic role of inflammation in this dysfunction.


Eligibility criteria:
inclusion criteria: * 18 - 24 years of age * no history of e-cigarette use (control) or current with 6 months or more history of e-cigarette use (chronic use). exclusion criteria: * tobacco cigarette use (current or history of) * use of stimulant drugs * skin diseases * cardiovascular disease * diagnosed or suspected hepatic or metabolic disease including diabetes * statin or other cholesterol-lowering medication * antihypertensive medication * current pregnancy or breastfeeding * blood pressure greater than or equal to 140mmhg systolic and/or greater than or equal to 90mmhg diastolic * allergy to materials used during the experiment * known allergies to salsalate or other study drugs
mold sensitization associated severe asthma exacerbation

Conditions: Asthma

Summary: mold sensitization is associated with severe asthma exacerbation.

mold sensitization has been reported to be one of the factors that is associated with severe asthma exacerbation (sae). the objective is to identify the factors that are associated with sae in asthmatic children particularly mold sensitization.

Eligibility criteria:
inclusion criteria: * asthmatic children aged 1-15 years old from pediatric allergy and immunology division with hospitalized due to severe asthma exacerbation in a preceding year and without severe asthma exacerbation in a preceding year exclusion criteria: * other serious systemic diseases, pregnant, lactation

Keywords: severe asthma exacerbation mold sensitization
a real-world clinical study of pyrotinib maleate tablets in the treatment of breast cancer patients with positive her-2

Conditions: HER2 Positive Breast Carcinoma

Summary: to evaluate the efficacy and safety of pyrotinib maleate tablets in the treatment of advanced breast cancer patients with positive her-2.

this study intends to carry out multicenter, observational cohort clinical research, using maleic acid pyrrole for his piece of her-2 positive treatment of advanced breast cancer treatment, observation and verification maleic acid pyrrole for his piece for a line or a single drug resistance by bead in the real diagnosis and treatment in patients with advanced breast cancer environment and the efficacy and safety of new treatments. biomarkers of breast cancer prognosis are of great significance in predicting the degree of malignancy, metastasis and recurrence of breast cancer, as well as guiding clinical treatment programs.this study will explore the prognostic factors and curative effect of breast cancer patients from multiple aspects, explore the dominant population of breast cancer patients with pyrrolidone maleate, and provide the theoretical basis for individualized treatment for clinical treatment practice.

Eligibility criteria:
inclusion criteria: 1. male or female patients . 2. confirmed by pathological examination of breast cancer patients with positive her-2 expression 3. the researchers determined that the standard neoadjuvant regimen was ineffective in the treatment of patients with locally advanced her-2 positive breast cancer or that the standard neoadjuvant regimen was not applicable. 4. patients should be voluntary to the trial and provide with signed informed consent 5. the researchers believe patients can benefit from the study. exclusion criteria: 1. patients with a known history of allergic reactions and/or hypersensitivity attributed to pyrotinib maleate tablets or its accessories 2. pregnant or lactating women 3. patients with pyrotinib maleate tablets contraindications 4. patients of doctors considered unsuitable for the trial

Keywords: pyrotinib maleate tablets her-2 real word study efficacy safety
presentation of first time attenders at lymphedema clinics

Conditions: Lymphedema; Breast Neoplasm

Summary: the first aim of this research project is to identify what factors motivate patients to seek assessment for early lymphedema and further, to gain insight into the signs and symptoms of developing lymphedema and the concurrent physical measurements. the second aim is to identify other sensory signs and symptoms and changes in body perception which may be perceived by the patient as reflective of lymphedema, and to identify to which degree they contribute to the patients' motivation to seek referral to lymphedema clinics.

one of the most challenging morbidities after breast cancer treatment is lymphedema. approximately 20% of women treated for breast cancer with axillary lymph node dissection will be diagnosed with lymphedema. pre- and post-operatively, women are informed about changes suggestive of lymphedema and guided about seeking further assessment. the investigators presume that if symptoms occur, patients will seek assessment. however, it is unknown whether this is true or if those prospectively monitored present earlier for treatment, or whether other factors specifically drive patients to seek further assessment. understanding the early experience and presentation of secondary lymphedema will improve patient education and detection programs.

Eligibility criteria:
inclusion criteria: * women after breast cancer (\> 18 years) with unilateral axillary lymph node dissection or sentinel node biopsy; mastectomy (with or without autologous reconstruction) or wide excision of the tumor * able to give consent to participate in the research exclusion criteria: * patients under the age of 18 years
three types of papilla incision in periodontal surgery

Conditions: Periodontitis; Periodontal Diseases; Periodontal Pocket

Summary: three types of papilla incision in periodontal reconstruction techniques will be compared.


Eligibility criteria:
inclusion criteria: * patients diagnosed with periodontal disease. * active residual pockets associated with intraosseous defects that did not resolve with non-surgical treatment after 1 year of maintenance. * intraosseous lesions with probing depth greater than 5 mm or extension of the radiographic defect greater than 4 mm. * plaque index and bleeding index less than 30%. exclusion criteria: * systemic disease that contraindicates periodontal surgery. * pregnant women. * third molars or teeth with incorrect endodontic or restorative treatment.
stimulation of diet-induced thermogenesis by cold-exposure

Conditions: Thermogenesis; Brown Adipose Tissue

Summary: human fat tissue is essentially white fat, the main function of which is to store excess energy intake, and to release it when necessary. brown fat is far less abundant and is present in the body to burn fat (and thus energy) to generate heat to maintain body temperature around 96 degrees. this phenomenon is called thermogenesis. when humans are exposed to cold on a chronic basis, brown fat expands and becomes more active, and consequently burns more energy. the amount of brown fat is higher during winter, and daily short (20 minutes) exposures to cold might be sufficient to induce its activity. we hypothesized that daily short term (20 minutes) exposure to a cold environment (4 °c) for four weeks increases adaptive bat-mediated thermogenesis. cit and dit will be increased proportionally (the increase in cit and dit will be correlated).

this study will have 3 phases: phase 1: baseline testing. this phase takes place at the beginning of the study to establish several physical, physiological and metabolic studies and includes measures of height, weight, body composition, sedentary and resting metabolic rate in a metabolic chamber as well as your metabolic and cardiac responses to cold. phase 2: cold exposure (treatment) phase. this phase is initiated immediately after phase 1 and will last 4 weeks. each work day (monday to friday) subjects will have to spend 20 minutes in a cold room wearing light clothes. phase 3: post-treatment testing. the same physiological and metabolic studies measured at baseline will be repeated over 3 days.

Eligibility criteria:
inclusion criteria: * men between the ages of 18-35 years, inclusive * body mass index (bmi) between 18.5 and 25.0 kg/m2, inclusive, with a stable weight (\<2kg variation) within the past 3-6 months * non smokers * on no medication or recreational drugs * healthy as assessed by a standard self-reported screening health questionnaire * provide written informed consent exclusion criteria: * smokers * individuals taking any medications * individuals taking any stimulants * individuals taking beta-blockers * individuals with diabetes or impaired fasting glucose as defined by theada criteria, i.e. fasting plasma glucose concentration ≥ 5.6 mmol/l (100 mg/dl). * individuals with chronic alcohol consumption (\> 3 drinks per day) or drug abuse * individuals unable to abstain from caffeinated beverage or alcohol the days of study * individuals with pacemakers or defibrillators * individuals with history of heart disease or history of stroke * individuals having a significant recent loss or gain of weight * individuals involved in regular (\> 3 times per week), intense competitive sporting activities. * individuals involved in intensive exercise activity.

Keywords: diet-induced thermogenesis cold-induced thermogenesis brown adipose tissue brown fat
assessment and validation of electronic gas and bloating diary

Conditions: Gas; Bloating; Distension; Constipation; Diarrhea

Summary: the investigator's goal is to improve the patient's compliance and accurate capture of patient reported gas and bloating symptoms, by utilizing a phone application that interactively records each gas and bloating event in addition to bowel events and other bowel symptoms. such an electronic stool diary may relieve the burden of using a paper daily stool diary. the investigator will compare and validate the electronic gas and bloating diary with the paper gas and bloating diary.

gas-related symptoms (grs) such as abdominal bloating, flatulence, and belching are some of the most common gastrointestinal complaints posed by the general population. these are hallmark symptoms in patients with functional gut disorders like irritable bowel syndrome but have also been linked to conditions such as gut hypersensitivity, altered gut microbiota and altered gut motility. the main issue with grasping the full impact of these symptoms on a patients' quality of life is that they are largely subjective and thus almost impossible to standardize. however, given their pervasiveness there is merit attempting to gauge their severity in as objective a manner as possible in order to track disease progress and response to treatment. grs can be widely irregular and requiring patients to call into the office to answer questionnaires post treatment or keep handwritten logs to turn in later can lead to inaccurate data collection that can hinder accurate diagnosis and management. the ubiquitous nature of smartphones and user-friendly interfaces of electronic applications allow for information to be logged/accessed remotely and securely, each log would have their own time stamp and be recorded in an organized, consistent manner.

Eligibility criteria:
inclusion/exclusion for gas and bloating subjects: inclusion: 1. anyone 18 to 80 years of age, inclusive with gas-related symptoms (grs) such as gas and bloating, plus any of the following: distension, diarrhea, and/ or abdominal discomfort. 2. normal upper endoscopy, normal colonoscopy (\ 50 years of age, normal computerized abdominal tomography scan, or a normal right upper quadrant scan exclusion: 1. women of childbearing age will be asked if they are pregnant, and a negative response will be sufficient. no pregnancy test will be performed. 2. history of previous gi surgeries (except for cholecystectomy, hysterectomy, and appendectomy) 3. significant co-morbid medical conditions, including stroke, copd( chronic obstructive pulmonary disease) and cancers (except for non-melanotic skin cancer) 4. recent hospitalization within 30 days of enrollment in this study 5. recent history (within 4 weeks) of antibiotic use 6. recent history (within one week) of a colonoscopy or barium study inclusion/exclusion for healthy subjects: inclusion: 1. anyone 18 to 80 years of age, inclusive with no medical problems and a negative bowel disease screening questionnaire.

Keywords: gas bloating distension constipation diarrhea
evaluation of a new digestive reconstruction procedure following pancreatoduodenectomy

Conditions: Pancreatic Cancer; Periampullary Carcinoma

Summary: the purpose of this study is to evaluate the validity and safety of a modified operative procedure of digestive tract reconstruction following pancreatoduodenectomy which enables the pancreatic juice and bile to bypass at the pancreatointestinal anastomosis and merge at gastrointestinal anastomosis. it is anticipated that this procedure can decrease the risk of post-surgical pancreatic leakage and preserve the patients' digestive function as well.

pancreatoduodenectomy (pd) is one of the most complicated surgeries in abdominal clinical practice. it is widely used in the treatment of pancreatic head carcinoma, periampullary carcinoma, chronic pancreatitis with intractable pain, pancreatic head mass which unable to rule out pancreatic cancer. pd was improved in many ways in the last 80 years and the post-surgical mortality has decreased under 5%. since the resected region of pd is wide including gall bladder, billiary tract, duodenum, pancreas, stomach, jejunum and regional lymph nodes. it has a high prevalence of complications, of which pancreatic leakage is the most common and serious one with a prevalence rate of 5-25% and mortality rate 20-50%。 the objective of the present study is to evaluate a new surgical procedure used for the digestive tract reconstruction following pd. the new procedure enables the pancreatic juice and bile to bypass at the pancreatointestinal anastomosis and merge at gastrointestinal anastomosis which can decrease the risk of post-surgical pancreatic leakage and keep the digestive function of patients. a multicenter, randomized, controlled study is designed to observe the prevalence of pancreatic leakage, other post-surgical complications, hospital stay, medical costs, life quality and other indexes to evaluate the efficacy and safety of this procedure. it is anticipated that through the study, this new procedure can be systematically verified if it is an ideal procedure of digestive reconstruction following pd which can be promoted into wider use.

Eligibility criteria:
inclusion criteria: * below 80 years old * ct (computed tomography), cta (computed tomographic angiography), mri (magnetic resonance imaging) or ultrasonic test suggested pancreatic head carcinoma, periampullary carcinoma, chronic pancreatitis with intractable pain, pancreatic head mass which unable to rule out pancreatic cancer, with or without obstructive jaundice/chronic abdominal pain. exclusion criteria: * liver metastasis * metastasis in common bile duct and hepatic duct * extensive lymph node metastasis, metastasis at hepatic portal or above pancreas * pancreatic head or periampullary has tight adhesion with postcava or aorta * distant metastasis * poor physical condition to tolerate anesthesia and surgery (e.g. severe cardio-pulmonary diseases, blood coagulation disorders)

Keywords: pancreatoduodenectomy digestive tract reconstruction pancreas
a study to characterize the outcomes of olaparib maintenance monotherapy in newly diagnosed brcawt ovarian cancer

Conditions: Advanced Ovarian Cancer

Summary: this study will collect the data from existing patient medical records at us cancer centers. the study will include patients with brcawt ovarian cancer who have been prescribed first line (1l) olaparib maintenance treatment.

this is a united states (us) based multicenter, retrospective, observational cohort study with data abstracted from patient medical records. in this observational study, it is planned to include approximately 150 us female patients with newly diagnosed advanced ovarian cancer (aoc) who were tumor biomarker tested between first diagnosis with aoc and first prescription of 1l olaparib maintenance monotherapy as tumor breast cancer gene wild type (brcawt) with a known homologous recombination deficiency (hrd) status. this retrospective cohort study will include patients with first olaparib prescription between jan 2017 and dec 2021. all data collection will be retrospective. data will be collected from the date of first olaparib prescription (index date) with a follow-up period of at least 18 months post index date.

Eligibility criteria:
inclusion criteria: * female adult, age ≥ 18 years * brcawt aoc diagnosed with any approved brca test * has documented hrd status based on available test results * received 1l olaparib maintenance monotherapy following platinum chemotherapy * patients must have been treated with platinum-based chemotherapy at first-line exclusion criteria: * received another poly adenosine diphosphate ribose polymerase (parp) inhibitor or bevacizumab before or while prescribed olaparib * participation in an interventional clinical study

Keywords: real-world evidence homologous recombination deficiency breast cancer gene breast cancer gene mutated breast cancer gene wild type
validity and reliability of ultrasound imaging for measuring coronal and sagittal angles in idiopathic scoliosis

Conditions: Ultrasonography; Coronal; Sagittal; Idiopathic Scoliosis; Validation Studies as Topic; Program Evaluation

Summary: patients with idiopathic scoliosis (is), especially children and adolescents, require regular follow-up evaluations. ultrasound imaging offers a reliable, radiation-free method for assessing spinal curvatures in the coronal and sagittal planes. while manual labeling in traditional ultrasound is error-prone, automated labeling reduces inaccuracies but still needs further validation, particularly in the sagittal plane. this study compared three-dimensional (3d) ultrasound assessments with conventional x-ray images--the clinical gold standard. and it is aimed to evaluate the validity and reliability of ultrasound measurements-ultrasound curve angle (uca) and ultrasound lamellar angle (usla)-against established radiographic benchmarks like cobb's angle, thoracic kyphosis (tk), and lumbar lordosis (ll).

this study was structured into two fundamental segments: 1) a dual-operator analysis focused on evaluating both intra- and inter-operator reliability of the uca and usla; and 2) a validation study of radiographic indices, specifically the coronal cobb angle, tk, and ll, in correlation with uca and usla measurements. initially, 100 patients diagnosed with is were subjected to both standard radiographic and 3d ultrasound examinations. owing to various exclusion criteria, 20 patients were subsequently disqualified from the study, resulting in a final sample of 80 patients for statistical evaluation. reliability assessments were conducted using the intraclass correlation coefficient (icc). furthermore, the validity of the uca and usla measurements was rigorously analyzed by comparing them against established radiographic benchmarks, utilizing pearson correlation coefficients and bland-altman plots for comprehensive evaluation. all expected or unexpected adverse events from this study will be recorded and monitored.for comprehensive analysis, participants were systematically categorized based on multiple demographic and clinical parameters: coronal angle (either ≥20° or \ 14 years or ≤14 years), and nutritional status (classified as normal or abnormal).

Eligibility criteria:
inclusion criteria: * patients with is who were cooperative with ultrasound procedures. exclusion criteria: * patients with spinal disorders such as marfan's syndrome, a history of ankylosing spondylitis, or spinal neurofibroma. * patients with severe medical or psychiatric conditions that could potentially impact the study results.

Keywords: ultrasonography coronal sagittal idiopathic scoliosis reliability validity