Kornimate/medical-research-clean huggingface dataset:
repeatability and response study of absorptive clearance scans

Conditions: Cystic Fibrosis

Summary: the investigators are developing a new nuclear medicine imaging technique for measuring liquid absorption in the airways that can be applied to screen new medications being developed to treat cystic fibrosis (cf). the investigators believe that the absorption of the small molecule radiopharmaceutical indium 111 diethylene triamine pentaacetic acid (in-dtpa) will indicate changes in liquid absorption in the airways and demonstrate whether new cf medications will be effective. in this study the investigators will determine whether the imaging technique will demonstrate similar results when it is repeated on different days. they will also determine how their results change when subjects utilize several common cf medications.

cystic fibrosis (cf) is an autosomal recessive genetic disease, caused by mutations of the cystic fibrosis transmembrane conductance regulator (cftr) that impairs ion transport at epithelial surfaces. this results in the accumulation of dehydrated secretions in the airways and chronic infection and inflammation in the lungs, leading to significant morbidity and mortality. the investigators understanding of cf pathogenesis has increased substantially and many new targeted therapies are being developed to treat this disease, however, the measurements of clinical efficacy used to evaluate these therapies require long trials to demonstrate an effect. new translational techniques are needed to assess changes in the most basic aspects of the disease and allow for the rapid screening of disease-altering therapies. the investigators have recently developed a novel aerosol-based imaging technique to measure liquid absorption in the airways - a central pathophysiological process related to cftr dysfunction. the investigators propose that airway liquid hyper-absorption is a key link between cellular defects in ion and fluid transport and progressive airway dysfunction in cf. thus the investigators technique may provide a measure of disease severity and rapid indication of therapeutic correction in advance of currently available outcome measures.

Eligibility criteria:
inclusion criteria: * subjects 18 years old or older with a diagnosis of cystic fibrosis as determined by sweat test or genotype and clinical symptoms who are clinically stable as determined by a physician co-investigator exclusion criteria: * one second forced expiratory volume (fev1) \<50% of predicted * nursing mother * positive urine pregnancy test or unwilling to test * cigarette smoker * unwilling to stop hypertonic saline therapy for 72 hours prior to each test day * are intolerant to hypertonic saline (response only) * are intolerant to any inhaled therapies (response only) * fail mannitol tolerance testing (response only) * have a history of excessive (uncontrollable) coughing after an osmotic stimulus (response only) * have a history of hemoptysis (response only)

Keywords: cystic fibrosis mucociliary clearance airway surface liquid nuclear medicine mannitol
dosing iodinated contrast media according to lean vs. total body weight

Conditions: Contrast Media Dosing

Summary: the purpose of this study is to evaluate the effect of dosing iodinated contrast media according to a patient's total body weight vs. lean body weight. participants will be randomized into 2 groups based on contrast dosing technique, and solid organ enhancement at uniphasic abdominal ct will be measured.


Eligibility criteria:
inclusion criteria: * outpatients only * patients scanned on modern siemens scanners at our institution exclusion criteria: * self-reported history of chronic kidney, heart or liver disease * allergy to iodinated contrast * acute illness * outside maximum threshold limit for weight-based contrast dosing * pregnancy * image degradation
feasibility and acceptability study of acuaware

Conditions: Chronic Pain

Summary: this study aims to gather preliminary feasibility and acceptability data to justify a subsequent trial that would fill a gap in knowledge regarding acupuncture therapy (at) effects on interoceptive awareness (ia) among those with chronic pain.

this study aims to gather preliminary feasibility and acceptability data to justify a subsequent trial that would fill a gap in knowledge regarding acupuncture's effects on interoceptive awareness among individuals with chronic pain. our primary hypotheses are that (1) feasibility: it is feasible for us to enroll and retain 70% of the patients and it is feasible to collect data from at least 70% of participants at 3-months follow-up, and (2) acceptability: it is acceptable for 70% of licensed acupuncturists to use acu-track registry; it is acceptable for 70% of patients to complete questionnaires emailed to them via acu-track registry. the investigators propose to evaluate these hypotheses by conducting a prospective, pragmatic single-arm feasibility and acceptability study among individuals with chronic pain of any etiology or location, except if due to cancer. chronic pain is defined as pain that persists or recurs for more than 3 months.

Eligibility criteria:
inclusion criteria: patients: * age 18 or older; * experiencing chronic pain, * complaint of 3+ months, * score of 5 or greater on a 1-10 scale; * able to provide informed consent * willing to sign an approved consent form that conforms to federal and institutional guidelines, * english speaking and writing. exclusion criteria: prior or current diagnosis of: * cancer, * multiple sclerosis (ms), * any dementia, * parkinson's disease, * autism spectrum disorder, * pregnancy, * fibromyalgia, * eating disorder, * down's syndrome * schizophrenia

Keywords: chronic pain feasibility study acceptability study
study on the infection risk of long dwell period catheters in high risk intensive care unit (icu) patients

Conditions: Burns

Summary: this is an evaluation of the use of silver impregnated catheters in burn patients to reduce catheter colonisation compared to the standard central venous catheter without antiseptic activity.


Eligibility criteria:
inclusion criteria: * burn patient * placement of a new trilumen central venous catheter

Keywords: colonisation of the catheter
a study to evaluate the effects of indacaterol maleate as a new formulation in the concept 1 device

Conditions: Asthma

Summary: this study will assess the pharmacodynamics, safety, tolerability and pharmacokinetics of two different formulations of indacaterol maleate, both administered via the concept1 device. the study aims to determine whether the novel formulation has a similar clinical profile as the established formulation.


Eligibility criteria:
inclusion criteria: * male and female patients with asthma * aged 18 or above * patients using inhaled corticosteroid (with or without long acting beta agonist) * patients who demonstrate an increase in fev1 after inhaling a short acting beta agonist exclusion criteria: * asthma exacerbations in previous 6 months * copd or other pulmonary disease * excessive use of short acting beta agonists

Keywords: asthma indacaterol qab149
exercise and diet intervention in promoting weight loss in obese patients with stage i endometrial cancer

Conditions: Estrogen Receptor Positive; Obesity; Progesterone Receptor Positive; Stage I Uterine Corpus Cancer; Stage IA Uterine Corpus Cancer; Stage IB Uterine Corpus Cancer

Summary: this pilot clinical trial studies exercise and diet intervention in promoting weight loss in obese patients with stage i endometrial cancer. exercise and diet may cause weight loss and minimize the risk of gynecologic surgery related to being overweight in patients with endometrial cancer.

primary objectives: i. to determine if participation in a 16-week exercise and diet intervention would elicit weight loss, assessed by a 10% decrease in fat mass, in endometrial cancer (ec) patients. secondary objectives: i. to determine if participation in a 16-week exercise and diet intervention would improve cardiorespiratory fitness (crf) and muscular strength. tertiary objectives: i. to determine if participation in a 16-week exercise and diet intervention could improve quality of life (qol), fatigue, and depression. ii. to determine the effects of a 16-week exercise and diet intervention on cardiovascular (cv) health. outline: patients undergo aerobic exercise thrice weekly over 95 minutes for up to 16 weeks. patients also undergo multi-lifestyle interventions based on the dietary approaches to stop hypertension (dash) diet once weekly over 1 hour for up to 16 weeks. after completion of study, patients are followed up for 16 weeks. after completion of study, patients are followed up for 16 weeks.

Eligibility criteria:
inclusion criteria: * clinical stage i ec * low grade disease positive for estrogen and progesterone receptors * body mass index (bmi) \>= 30 kg/m\^2 * no history of any musculoskeletal, cardiorespiratory or neurological diseases that preclude the participation in exercise * self ambulatory and without use of assistive walking devices * is not a candidate for immediate hysterectomy, following evaluation by a physician, due to desire to preserve fertility, due to degree of obesity, due to comorbidities, or due to patient refusal of hysterectomy * must agree to take progestin agents (i.e., oral agents or mirena intrauterine device \[iud\] which are accepted treatments for low grade uterine malignancies to control their disease while the intervention is ongoing) * note: potential participants will not be asked to delay surgery to participate in this pilot study exclusion criteria: * patients with metastatic disease * bmi =\< 29.9 kg/m\^2 * history of any musculoskeletal, cardiorespiratory or neurological diseases that preclude the participation in exercise * is not self ambulatory and relies on the use of assistive walking devices * is a candidate for immediate hysterectomy, following evaluation by a physician * in judgement of a physician, is not a candidate for progestin agents
transition of adolescents and young adults with diabetes from pediatric to adult care

Conditions: Type 1 Diabetes

Summary: the purpose of the study is to compare two interventions for preparing diabetic teens and young adults for transition from pediatric to adult diabetes care.

one will represent a short-term intensive social-behavioral intervention supported by peer-to-peer social networking in which subjects receive "usual care" from their current diabetes provider outside the parameters of the study. the second intervention will be a traditional transition clinic model, where subjects will receive the standard of diabetes care from a team of combined pediatric and adult practitioners and educators, with added educational modules and behavioral evaluation and support designed to facilitate the transition to adult care (i.e., that foster "developmentally tailored care"). the first is a much less intensive intervention from the standpoint of the providers and gives special prominence to peer support; the second is provider-intensive. the goal of both interventions is to improve self-efficacy (confidence in taking ownership of and managing one's diabetes); i.e., to prepare the patient to move from primary support by family and providers to a reliance on self-ownership and self-management as a responsible, independent adult. optional sub-study available for parents, spouses, and significant others.

Eligibility criteria:
inclusion criteria: * age 16-29 * diagnosis of type 1 diabetes, or type 2 diabetes managed with insulin, at least one year prior to study initiation * english-speaking * some form of private or public (e.g., medicaid) health insurance exclusion criteria: * cystic fibrosis-related or pancreatitis-related diabetes * diabetes related to a known specific genetic defect such as down's syndrome, lipoatrophic diabetes, leprechaunism or rabson-mendenhall syndrome, etc. * chronic liver disease * history of chronic renal failure * serious psychiatric illness that in the judgment of the investigators would preclude the individual's ability to complete the study * pregnant or planning to become pregnant within 6 months
penn microbiome therapy for recurrent clostridium difficile infection

Conditions: Recurrent Clostridium Difficile Infection

Summary: this is a randomized, open label, comparative, phase ii study to determine which dose of fecal microbiota transplant using penn microbiome therapy (pmt) products is most effective in treating and preventing recurrence of clostridium difficile infection (c diff).


Eligibility criteria:
inclusion criteria: 1. second or greater episode of cdi (first or greater recurrence) within 12 months, with symptoms including bowel movement altered in frequency or consistency from baseline. 2. stool positive for c. difficile toxin by eia or toxin gene by naat within 60 days of enrollment. 3. at least one additional prior positive stool test for c. difficile within the prior 12 months (eia or naat as above). 4. age ≥ 18 years. 5. minimum of 72 hours of receipt of standard-of-care (vancomycin or fidaxomicin) antibiotic treatment for r-cdi prior to intervention. exclusion criteria: 1. evidence of colon/small bowel perforation at the time of study screening 2. goals of care are directed to comfort rather than curative measures. 3. moderate (anc \< 1000 cells/ul) or severe (anc \< 500 cells/ul) neutropenia. 4. known food allergy that could lead to anaphylaxis. 5. pregnancy a. for subjects of childbearing potential (ages 18 to 55), the subject must have a negative urine pregnancy test within 48 hours of consent and no more than 48 hours prior to first product administration 6. meeting criteria for severe, severe-complicated/fulminant cdi within 24 hours of planned trial enrollment. we define severe or severe-complicated/fulminant cdi as any one of the following: (1) leukocytosis with peripheral wbc ≥ 15,000 cells/ml; (2) hypotension with systolic blood pressure sustained \ 2.2 mmol/l; or (6) ≥ 3 systemic inflammatory response syndrome (sirs) criteria (which include heart rate \> 90 beats per minute, respiratory rate \> 20 breaths per minute or paco2 \ 38ºc or \ 12,000 cells/ul, \ 10% immature (band) forms). 7. receipt of fmt or enrollment in a clinical trial for fmt within the last 3 months.
acute pancreatitis and home care vs. hospital admission study

Conditions: Acute Pancreatitis; Home Care

Summary: acute pancreatitis (ap) is one of the most common reason for hospitalization among gastrointestinal diseases in u.s.. the costs caused by severe ap are higher than mild ap. nevertheless, approximately 70% of hospital admissions for ap are mild cases, if health cost saving is to be realized, it would be by lowering the cost of managing patients with mild ap without affecting patient's safety and satisfaction. with the padi-1 study, where it was possible to confirm the benefits of an early diet, the rapid recovery of patients with mild ap and the reduction of hospital costs, now a new scope is to be given in the treatment of patients with this pathology. considering the application of predictive factors of ap severity, and being sure of diagnosing mild ap, a study of home care versus hospitalization for patients with mild ap is proposed. based on the hypothesis that outpatient care of mild ap patients would be as sage and affective as hospitalization, the aim this study is to campare the results of 3 different strategies of treatment of patients with ap mild. additionally, satisfaction patient and costs will be analyzed.

this is prospective, randomized, controlled, multicentre trial. objectives primary objective compare the results of 3 different strategies for the management of patients with mild acute pancreatitis (ap) and to analyze differences in satisfaction patients and economic costs. methods patients with mild ap will be randomly in three groups: group a: outpatient treatment, group b: medical home care and group c: hospitalization. the primary and several secondary endpoints will be obtained: 1. treatment failure rate (the primary endpoint). 2. serum amylase, lipase, electrolytes, bun (blood urea nitrogen), creatinine, liver function tests, and full blood count at hospital admission, 24 hours and 72 hours. 3. relapse pain. 4. diet intolerance. 5. systemic complications including hemodynamic instability, renal failure, intensive care admission, surgery, radiological and endoscopic procedures. 6. pain and analgesic requirement. 7. local complications including pancreatic necrosis, abscess, pseudocyst. 8. health costs 9. patient satisfaction

Eligibility criteria:
inclusion criteria: 1. diagnosed of ap by at least two of these three criteria: compatible abdominal pain, amylase or lipase level superior in three-fold respective laboratory baseline levels, and suitable findings in imaging techniques (ct, ultrasound or mri). 2. age \> 18 years, sign consent form. exclusion criteria: 1. pregnant o breastfeeding women. 2. abdominal pain lasting \>96 horas before admission. 3. the possibility of poor oral intake for reasons other than ap. 4. pancreatic neoplasm, endoscopic retrograde cholangiopancreatography or trauma etiology, biliar obstruction. 5. chronic pancreatitis. 6. asa ≥3. 7. randomization lesser the 24 hours after randomization.

Keywords: pancreatitis
metformin use and clinical pregnancy rate in women with unexplained infertility

Conditions: Infertility

Summary: the aim of this study is to asses the effect of metformin on clinical pregnancy rate in women with unexplained infertility (randomized controlled trial). this study will be conducted in infertility clinic,ain shams university maternity hospital,170 women with unexplained infertility will be enrolled in this study. statistical analysis of the data will be performed .

metformin is usually used with induction regimen in patients with pcos as it improves ovulation rate by direct effect on ovarian tissue,metformin will be used in combination with clomiphene citrate in women with unexplained infertility with previous failed cycle to asses its efficacy on clinical pregnancy rate. study will be conducted in infertility clinic,ain shams university maternity hospital.study population comprises women with unexplained infertility aged 20-35 years with total sample size of 170 who willbe randomized into two groups with 85 women in each group. group a:is case group who will receive metformin plus clomiphene citrate. group b:is control group who will receive clomiphene citrate plus placebo. metformin will be started at time of booking and will be continued till pregnancy is confirmed in a dose of 850 mg twice daily in form of tablet. vaginal ultrasound is done for all in day 2 to exclude presence of ovarian cyst and to identify normal appearance of ovaries,then folliculometry on day 9 followed by serial folliculometry every other day till reaching dominant follicle 18 mm or more where hcg intramuscular injection will be given in a dose of 10000 iu . serum pregnancy test will be done after 16 days. transvaginal ulterasound will be done on day 35.

Eligibility criteria:
inclusion criteria: * age 20-35 years old. * bmi 20-\<30 * fsh 12 iu/l or less * normal transvaginal ulterasound(normal uterus and ovaries with no congenital anomalies). * patent fallopian tubes assesd by hysterosalpingogram or laparoscopy. * normal semen analysis. * infertile women with history of previous failed induction cycle. exclusion criteria: * women younger than 20 or elder than 35 years old. * women with bmi equal to or more than 30. * uncorrected congenital or acquired uterine anomaly. * other causes of infertility rather than unexplained infertility. * patient with diabetes mellitus.

Keywords: metformin,unexplained infertility
the effect of automatic massage applied to healthcare workers on pain, fatigue and psychological well-being

Conditions: Massage; Pain, Back

Summary: to determine the effect of automatic massage applied to healthcare workers on pain, fatigue and psychological well-being. this research is planned as a pretest-posttest type study. it will be held in the osmaniye state hospital maternity ward. the application will be applied by one person in the rest room. data will be collected using the introductory information form, psychological well-being scale, perceived stress scale (asö/psö-14), state-trait anxiety inventory (stai), and piper fatigue scale.


Eligibility criteria:
inclusion criteria: * working in the delivery room exclusion criteria: * being receiving psychiatric treatment (pharmacotherapy or psychotherapy), * having a wound on the waist and back that prevents the application.
differential trough effects of 'triple therapy' on pulmonary function in chronic obstructive pulmonary disease (copd)

Conditions: COPD

Summary: different medications are often used in combination for the condition copd (chronic obstructive pulmonary disease). some medicines act by opening the airways (bronchodilators) and some act as anti-inflammatories (steroids). more recently an approach of using a combination inhaler (containing a steroid and a long-acting bronchodilator) at the same time as a long acting bronchodilator of a different group of medicines (anti-cholinergics inhalers) has been used. this approach is sometimes called 'triple therapy'. studies which have looked at these combinations usually use only standard blowing tests (spirometry) to test these medicines and focus on the effects of the medicines at their highest (peak) levels. it is some ways more relevant to study these medicines towards to end of the dose period (trough)- just before the next dose. this is when there is less medicine in the system, and differences in drug effects are more obvious. there are also more detailed breathing tests than spirometry which get a more detailed picture of the way the lungs respond to bronchodilator medicines. the investigators have studied 'triple therapy' in copd, by measuring the effects at the end of the dosing interval (trough) using a range of detailed respiratory tests.


Eligibility criteria:
inclusion criteria: * current or ex-smokers * aged over 50years * fev1/fvc ratio less than 0.7 * fev1 less than 60% predicted exclusion criteria: * diagnosis of asthma, abpa or bronchiectasis * recent rti or steroid use * inability to perform study procedures or to give informed consent * known sensitivity to trial medications

Keywords: copd (chronic obstructive pulmonary disease)
efects of noninvasive mechanical ventilation and conventional mechanical ventilation in patients with severe comunity pneumonia

Conditions: Community Acquired Pneumonia.; Acute Hypoxemic Respiratory Failure

Summary: the purpose of this study is to determine whether the noninvasive ventilation is more effective in the treatment of severe comunity acquired pneumonia in comparison with the conventional mechanical ventilation with orotracheal intubation.


Eligibility criteria:
inclusion criteria: the criteria for the diagnosis of scap included: * blood systolic pressure lower than 90 mmhg or blood diastolic pressure lower than 60 mmhg * rr higher than 30 breaths per minute * pao2/fio2 lower than 250 while breathing through a venturi mask with a 50% inspired oxygen fraction (fio2) * bilateral or multiple lobar infiltrations evidenced by thorax x-ray, and * use of vasopressor drugs exclusion criteria: exclusion criteria included: * copd * asthma * acute cardiogenic pulmonary edema * severe haemodynamic instability (arterial systolic pressure lower than 70 mmhg) or requirements of vasoactive drugs * glasgow score equal to or lower than 9 or requiring oti for airway protection or for recent pulmonary resucitation * antecedents of respiratory failure resulting from neuromuscular pathology * failure of two or more organs * facial deformities; and * recent facial, aesophagic and gastric surgeries

Keywords: severe community-acquired pneumonia noninvasive mechanical ventilation acute hypoxemic respiratory failure.