Kornimate/medical-research-clean huggingface dataset:
3d ultrasound-guided labor epidural analgesia in the morbid obese parturient

Conditions: Obesity, Morbid; Pregnancy; Pain

Summary: this study will be a randomized control study, with the objective to evaluate epidural analgesia success rates between the two methods (blind approach versus accuro device).

worldwide obesity has become an epidemic. the obstetrical population is no exception. this made more challenging for anesthesiologists on labor and delivery units to administer epidural analgesia. according to the world health organization, more than 30% of u.s. adults are obese with a body mass index (bmi; in kg/m2) ≥ 30. recent data has shown that increased bmi has been associated with increased neuraxial analgesic failure and difficulty with prolonged epidural placement time. the 'blind approach' is the current standard of care in administering neuraxial anesthesia. the physician palpates the patient's spinal bony landmarks; the needle is placed in relation to identified landmarks and inserted until loss of resistance is felt. in the obese population, the success rates are as low as 68%. recently the fda has approved a handheld device "the accuro" as an adjunct for neuraxial analgesia (rivanna medical, llc). it consists of a three-dimensional ultrasound device. by utilizing sound waves it constructs three-dimensional images of the spinal column, allowing the physician to better see the spine in order to perform spinal/epidural anesthesia. hypothesize that this device will enable clinicians to assess epidural spaces for epidural needle placement compared with the traditional blind approach in the morbidly obese parturient. this study will be a randomized control study, with the objective to evaluate epidural analgesia success rates between the two methods (blind approach versus accuro device). also, will determine if ultrasound based landmarks would reduce the needle tract and thereby reduced the amount of post-procedure pain at the insertion site in the peripartum period by using the algometer.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists physical status class i, ii, or iii. * term pregnancy. * requesting epidural analgesia for anticipated vaginal delivery. * bmi\>or = 40. exclusion criteria: * contraindication for epidural analgesia * inability to adequately understand the consent form. * incarcerated patients. * patients with known spinal deformities. * allergies to ultrasound gel. * allergies to local anesthetics

Keywords: labor analgesia ultrasound obesity, morbid pregnancy labor epidural analgesia
ultrasound guided caudal block for benign anal surgery

Conditions: Anal Fissure; Anal Fistula; Hemorrhoids; Pain, Postoperative

Summary: interventional study that evaluate analgesia and side effects of ultrasound guided caudal block preoperatively in benign canal anal surgery

postoperative pain is an important symptom in patients after benign anal canal surgery. caudal block has been described to decrease postoperative pain in this type of surgery. ultrasound is a tool that facilitates its performance and increases the rate of a successful block. objective: to determine the usefulness of ultrasound guided caudal block in anesthesia and postoperative analgesia in patients scheduled for benign anal surgery. methods : interventional study in adult patients that received ultrasound caudal anesthetic block before benign anal surgery. the investigators evaluated analgesic efficacy of this intervention by mean of numeric rating scale ( nrs) for pain after 6, 12 and 24 hours of surgery, rescue analgesia, motor block, urinary retention, surgical conditions and patient satisfaction in postoperative period.

Eligibility criteria:
inclusion criteria: * age from 18 to 70 year old patient * schedule for benign anal surgery ( hemorrhoids, anal fistula, fissure or abcess ) * caudal analgesic injection before surgery * use of ultrasound to guide needle insertion into caudal space exclusion criteria: * cognitive impairment * verbal communication impairment * infection in skin at injection site * coagulopathy * technique refusal

Keywords: ultrasound guided caudal block anal surgery
estimation of the localization accuracy of the genicular ablation procedure applied for chronic pain suppression

Conditions: Knee Osteoarthritis

Summary: estimation of the localization accuracy of the genicular ablation procedure applied for chronic pain suppression


Eligibility criteria:
inclusion criteria: * patients aged 18 years and older. * diagnosed with primary degenerative osteoarthritis. * complaining of knee pains * patients clinically eligible for genicular nerve ablation procedure non-electively based on physical examination * patient signed icf exclusion criteria: * co-morbidities: patient suffers from neuropathy, bony tumors, traumatic fractures and dm. * claustrophobic or failing cooperativity assessment of laying still during long mri scans * pregnancy or pregnancy suspicion * enrolled in concurrent studies that may confound the results of this study * clinical condition that in the investigator's opinion would not allow the subject to complete the study, e.g., tremor, extreme obesity, mental disorders.
efficacy of clarithromycin treatment in prevention of chronic lung disease in premature infants

Conditions: Chronic Lung Disease

Summary: the purpose of this study is to evaluate the efficacy of clarithromycin in eradication of ureaplasma urealyticum and prevention of chronic lung disease in premature infants with birthweight \< 1250 g and have ureaplasma urealyticum colonization.


Eligibility criteria:
inclusion criteria: * the babies under 1250 gram * the babies must be appropriate for gestational age exclusion criteria: * multiple congenital anomalies or known syndromes * intrauterine growth retardation with birthweight less than 10 percentile for gestational age

Keywords: chronic lung disease clarithromycin ureaplasma urealyticum
efficacy and safety of aae581 in postmenopausal women with osteopenia/osteoporosis.

Conditions: Osteoporosis

Summary: aae581 is a specific inhibitor of the cysteine protease cathepsin k. this trial is designed to provide detailed information about the effects( efficacy and safety) of aae581 on bone mineral density.


Eligibility criteria:
inclusion criteria: * low spine bone mineral density * 0 to 1 prevalent fracture in non lumber spine exclusion criteria: * history or presence of any bone disease other than osteopenia /osteoporosis * previous treatment with other anti-osteoporosis agent(wash out required) * evidence of vitamin d deficiency other protocol-defined inclusion/exclusion criteria may apply.

Keywords: osteoporosis postmenopausal women cathepsin k inhibitor
effects of neuromuscular electrical stimulation on critically ill patients with mechanical ventilation

Conditions: Respiratory Insufficiency Requiring Mechanical Ventilation

Summary: up to 25% of patients who require mechanical ventilation (mv) more than seven days in the intensive care unit (icu) develop muscle weakness, which comprises deep muscle weakness , including the respiratory muscles.early active mobilization in icu patients is a safe and viable strategy to prevent the physical problems caused by immobility. neuromuscular electrical stimulation (nmes) is an alternative to mobilize and exercise because it does not require active patient participation and can be used on bedridden patients.no previous studies have shown whether training-specific respiratory muscles using an electrical stimulation can have overall benefits for icu patients on mv.for this reason, the aim of this study was to evaluate, the effectiveness of the nmes therapy combined with early rehabilitation in the respiratory muscles of patients on mv.


Eligibility criteria:
inclusion criteria: * prolonged mv(\>72 h); * written informed consent was obtained from the patients or their relatives exclusion criteria: * previous neuromuscular disease; * unrelieved pneumothorax, restricted diaphragmatic dyskinesia including abdominal high pressure, a large number of ascites * thoracic or diaphragmatic malformation; * local skin damage and infection; * indwelling a temporary or permanent pacemaker; * severe obesity(bmi\>35 kg/m2) * various reasons (severe intestinal gas accumulation, structural abnormalities) lead to the failure of ultrasonic detection of diaphragm movement; * patients with an expected survival time of less than 7 days or with palliative care

Keywords: diaphragm ultrasound intercostal muscle ultrasound
twentyfour ambulatory pulse wave velocity and central augmentation index in type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the functionality and reproducibility of pulse wave analysis is investigated in 20 type 2 diabetic patients who had two 24 hour measurements performed within one week with the arteriograph24 equipment.

arteriograph24 is a new monitor for measuring ambulatory blood pressure and additional performing brachial cuff based on analysis of a suprasystolic pulse wave. the study aim to test the feasibility of ambulatory pulse wave analysis every twenty minute (the fraction of missed measurements)and the reprodicility of pulse wave velocity and central augmentation index in type 2 diabetic patients. in addition we will explore the relation between diurnal variation of brachial blood pressure, central blood pressure and pulse wave velocity. 20 type 2 diabetic patients will have 24h ambulatory blood pressure performed twice with an interval of one week.

Eligibility criteria:
inclusion criteria: * type 2 diabetes exclusion criteria: * atrial fibrillation

Keywords: pulse wave analysis pulse wave velocity arteriograph24 ambulatory diabetes reproducibility diurnal variation
formative validation of the movechecker system

Conditions: Epilepsy

Summary: obtain motion sequences of at least 60 epileptic seizures

extensive movement data are required to develop an automatic pattern recognition that makes it possible to distinguish movements of epileptic seizures from everyday activities. the aim of collecting formative validation data for the system is to collect movement data from as many epileptic seizures as possible to develop such pattern recognition in the future. a system is being investigated that uses several non-invasive sensors attached to the extremities and trunk of the test subjects with plasters to record abnormal movement patterns and play them back to detect epileptic seizures with motor involvement. in the study registered here, the movement data of at least 60 epileptic seizures with motor components will be recorded parallel to routine diagnostics using video eeg or video monitoring. the primary goal is to collect formative validation data for the system. this includes recording the movements of at least 60 epileptic seizures per sample during the hospital stay of the participants to develop future pattern recognition for the system. the secondary goals include the qualitative assessment of the clinical benefit of the system from the point of view of the patient and the medical staff.

Eligibility criteria:
inclusion criteria: * 18 years or older * diagnosis of epilepsy (icd code g40.x) exclusion criteria: * suspected epilepsy (no diagnosis) * comorbidities affecting the motor system * dermatosis in an area of the body relevant to the sensor attachment * contact allergy due to plaster or sensor material * known or current illness or disorder that interferes with the ability to understand study participation requirements or to provide informed consent
a novel diagnostic method for exotropia using video-oculography

Conditions: Strabismus; Exotropia

Summary: thirty-four subjects with constant exotropia were included. two independent ophthalmologists measured the angle of ocular deviation using alternate prism cover test (apct). the video files and data with the changes in ocular deviation during the alternate cover test were obtained using video-oculography (vog). to verify the accuracy of vog, investigator compared the value obtained using vog and the angle of a rotating model eye, and subsequently made a new linear equation using these data. the calculated values obtained using vog were compared with those obtained using apct to determine the diagnostic accuracy of vog.


Eligibility criteria:
inclusion criteria: * have horizontal strabismus, cooperative, visual acuity \>= 1.0/1.0 exclusion criteria: * have vertical strabimus\> 5prism diopter, not cooperative, no agree
treatment of hepatorenal syndrome with terlipressin infusion adjusted to hemodynamic response

Conditions: Cirrhosis; Hepatorenal Syndrome Type I

Summary: observe the effect of terlipressin on renal function in patients with shr type i adjusting the dose based on hemodynamic response.


Eligibility criteria:
inclusion criteria: * patients with hepatorenal syndrome type 1. * signed informed consent. * no exclusion criteria. * at least 18 years old * negative pregnancy test in serum or urine in women of childbearing age, and agree to use adequate contraception since at least 14 days prior to the first dose of study drug until 14 days after the last. exclusion criteria: * hepatocellular carcinoma: exclusion of patients with hepatocellular carcinoma who present more than 3 nodules, single nodule larger than 5 cm, tumor portal thrombosis or extrahepatic tumor spread. * active bacterial infection with symptoms of systemic inflammatory response (fever, tachycardia, tachypnea, hypotension, septic or blood count). * cardiac or respiratory failure clinically significant. * clinically significant peripheral artery disease. * a history of ischemic heart disease. * hypersensitivity to terlipressin and / or albumin or any of the excipients. * pregnancy. * septic shock. * chronic renal failure. * women in lactation
probiotics in women with primary dysmenorrhoea

Conditions: Primary Dysmenorrhea

Summary: this study compares the effect of probiotics versus placebo in women with primary dysmenorrhoea

this is a randomized controlled trial comparing probiotics against placebo in women with primary dysmenorrhoea

Eligibility criteria:
inclusion criteria: * regular menstrual cycles between 21 to 45 days * primary dysmenorrhoea only * willing to consume sachets twice daily for 3 months exclusion criteria: * current intrauterine copper device (iucd) user * recent hormonal (estrogen or progesterone) therapy in last 3 months * on treatment for allergy such as antihistamine * diarrhoea with dairy product * often take drugs which may affect the test results (such as medicines treating constipation or digestive medicine such as laxatives or enema) * any malignant tumor regardless of type or site

Keywords: probiotics
multicenter study of generation comorbidity score

Conditions: Death

Summary: the purpose of the study is to generate and valid a co-morbidity score with updated definitions and suitable for use in argentina in both public and private settings. these tools would allow us to compare different populations in argentina adjusting for comorbidities. also, this would potentially help attending physicians and health administrators.

the investigators will generate a co-morbidity score, perform the score validation and generate an online calculator for the score (open access). finally, a score validation for extreme values of score will be performed to ensure representativeness of these patients.

Eligibility criteria:
inclusion criteria: * adult 17 older * admitted to hospital within 72 hours of admission * non programed admission exclusion criteria: * negative to participate * 72 hs mortality expected * obstetrics admissions
a comparative study of different traditional and bioactive indirect pulp capping materials

Conditions: Deep Carious Lesions; Caries Class I; Caries Class II

Summary: the protection of the dentin-pulp complex consists of the application of one or more layers of specific material between the restorative material and dental tissue to avoid additional challenge to the pulp tissue caused by operative procedures, toxicity of restorative materials and bacteria penetration due to microleakage. protection of the dentinpulp complex has also the function to recover pulp vitality.the materials that can be used for this purpose are varnishes,calcium hydroxide (ch)-based products, glass ionomer cements (gics) and adhesive systems.the biological compatibility together with the sealing capabilities of dental materials is of paramount importance to avoid or limit pulp tissue irritation and dentinal hypersensitivity.

pulp plays an important role in the formation and nutrition of dentin as well as in the innervation and defense of the teeth. the primary pulp function is dentin formation, which begins in the moment that the peripheric mesenchimal cells differentiate into odontoblasts and starts the deposition of collagen matrix, in a sequence of deposition/mineralization that ends with the complete tooth formation. even after the initial formation, pulp continues to physiologically produce dentin due to the tooth aging. reparative dentin may also be produced in response to physical and/or chemical injuries. odontoblasts maintain their processes inside the newly formed tissue, thus creating real channels that are responsible for dentin nutrition. changes in the flow of the fluid in the dentinal tubules can trigger pain receptors present on nerve endings in the pulpal aspect to fire nerve impulses, thereby causing pain . this hydrodynamic flow can be increased by changes in temperature, humidity, air pressure and osmotic pressure, or forces acting on the tooth. hot or cold foods and drinks, and physical pressure are typical triggers in people with dentin hypersensitivity.

Eligibility criteria:
inclusion criteria: 1. patient's age ranges from 20-50 years old with vital first permanent molar tooth on testing by vitality test, such as thermal or electrical pulp tester. 2. class i or ii cavities. 3. deep carious lesions. 4. absence of clinical signs or symptoms suggesting non-vital tooth such as spontaneous pain, tenderness to percussion, abscess, fistula, periodontal tissue swelling, or abnormal tooth mobility. 5. sufficient tooth structure for restoration. 6. healthy patients with good general health. 7. patients are cooperative and motivated. exclusion criteria: 1. patient with systemic diseases such as uncontrolled diabetic, cardiovascular diseases, or patient received chemotherapy or radiotherapy. 2. history of spontaneous, unprovoked toothache or mobility, (grade i, ii and iii). 3. sensitivity to percussion, external or internal root resorption, periapical lesions or presence of a fistulae. 4. pregnant females. 5. drug abuser patients. 6. previously restored teeth.
iv haloperidol for the treatment of headache in the ed

Conditions: Headache; Migraine Disorders

Summary: single center, double-blind, randomized, placebo-controlled trial evaluating analog pain scores in patients who present to the emergency department (ed) with a complaint of headache. a total of 150 patients age 13-55 presenting to the emergency department with headache will be enrolled from october 2015 - october 2016. patients will be randomized and pain scores and side effects will be recorded at 0, 30, 60, and 90 minutes. follow-up will be performed by telephone at 24 hours.


Eligibility criteria:
inclusion criteria: * emergency department patients that complain of headache or migraine * males and females age 13-55 * english is primary language exclusion criteria: * abnormal blood pressure (\>200/100) * sudden rapid onsent (normal to worst pain in minutes) * fever * trauma * any history of masses, strokes, head injury or other causes of abnormal anatomy * qt greater than 450 ms on ekg * allergy to haldon * any altered mental status (gcs \<15) * pregnancy * any abnormalities on neurologic exam * any clinician concern that would require ct scan of brain * any prisoner or ward of state
comparing minimal invasive surgery en conventional total knee arthroplasty

Conditions: Osteoarthritis, Knee

Summary: randomized clinical trial comparing minimal invasive operating technique to conventional operating technique for placement of total knee prosthesis. clinical evaluations, patient questionnaires, x-rays and ct scans were done to compare these two techniques.

study executed with 3 centers and 69 patients.

Eligibility criteria:
inclusion criteria: * patient requiring total knee arthroplasty (tka) * patients with osteo arthritis * intact collateral ligaments and patella tendon * patients willing and able to comply with the post-operative schedule exclusion criteria: * patients who require a revision tka * patients with tka contralateral knee within 6 months with bad outcomes * patients who need a tka on contralateral side within 2 years * intraoperative resurfacing of patella * intraoperative eversion of patella * patients who had prior procedure of involved knee such as high tibial osteotomy, cruciate ligament recontruction, knee fusion or patellectomy * bmi \> 30 * patients with fixed flexion contracture\> 15 degrees * patients with deformity greater than 20 degrees of varus or 15 degrees of valgus * patient with mediolateral stability \> 10 degrees patient with active or suspected malignancy * patient with rheumatoid arthritis * patient with systemic disease that would effect subject's wellfare or overall outcome of the study * patient with other severe concurrent joint involvement which can effect their outcome * patients with an immobile hip * patient with a history of pulmonary embolism or deep venous thrombosis
intuitive eating for disordered eating

Conditions: Eating Disorder Symptom; Eating Behavior; Body Image; Psychological Distress

Summary: purpose: research on intuitive eating is growing, but there are few interventions demonstrating the effect of learning to eat intuitively for people with disordered eating. young women in particular are at high-risk for developing disordered eating. this study aimed to test the outcomes of a novel intuitive eating intervention for young women with disordered eating. methods: this study is the first randomized controlled trial introducing intuitive eating to a sample of participants with disordered eating. participants with current eating disorders were excluded from this study. women (n=123) ages 18-30 with high levels of disordered eating participated in this study and were randomized to either a treatment (10-week web-based intervention) or control group (10-week waitlist).


Eligibility criteria:
inclusion criteria: * female * between 18 and 30 years of age * located in the united states or canada * no eating disorder * no previous participation in an intuitive eating intervention * score greater than or equal to 25 on the tfeq-r18 at baseline exclusion criteria: * gender not female * younger than 18 years of age * older than 30 years of age * located outside the united states or canada * score less than 25 on the tfeq-r18 at baseline * previously participated in an intuitive eating intervention * current eating disorder
ublituximab + tgr-1202 compared to obinutuzumab + chlorambucil in participants with untreated and previously treated chronic lymphocytic leukemia

Conditions: Chronic Lymphocytic Leukemia

Summary: this study evaluates the combination of ublituximab, a novel monoclonal antibody, and tgr-1202, a novel pi3k delta inhibitor compared to obinutuzumab and chlorambucil, and compared to ublituximab or tgr-1202 alone in chronic lymphocytic leukemia (cll) participants.


Eligibility criteria:
inclusion criteria: * treatment naïve or previously treated chronic lymphocytic leukemia (cll) requiring treatment * eastern cooperative oncology group (ecog) score of 0 to 2 exclusion criteria: * any major surgery, chemotherapy or immunotherapy within the last 21 days * evidence of hepatitis b virus, hepatitis c virus or known hiv infection * autologous hematologic stem cell transplant within 3 months of study entry. prior allogeneic hematologic stem cell transplant is excluded * transformation of cll to aggressive non-hodgkin's lymphoma (nhl) (richter's transformation) * prior therapy with obinutuzumab and/or chlorambucil or a pi3k delta inhibitor