Kornimate/medical-research-clean huggingface dataset:
investigation of the transmission pathways of reflux in patients with chronic venous insufficiency

Conditions: Venous Insufficiency

Summary: chronic venous insufficiency (cvi) is one of the most common medical problems in adults that occurs secondary to the reflux of blood through incompetent valves of lower extremity veins. the most common involved valve is the valve located at the saphenofemoral junction. although the pathway of reflux transmission is not the same in all patients, the removal or ablation of the greater saphenous vein (gsv) is considered a standard treatment in these patients. however, in patients whose reflux is transmitted to branches other than gsv, this treatment leads to the unnecessary destruction of a competent segment of gsv in addition to remaining at least some segments of incompetent veins. so, in this study, the investigators intend to investigate the different pathways of reflux transmission in chronic venous insufficiency patients who are candidates for gsv ablation/stripping because of saphenofemoral junction insufficiency. this cross-sectional study will be conducted with a descriptive-analytical approach. .

chronic venous insufficiency is one of the most common medical diseases in adults, which severely affects the quality of life of affected patients. what causes symptoms in this disease is the reflux of blood through incompetent valves located in the lower extremity veins. the most common cause is saphenofemoral valve insufficiency. although the pathway of reflux transmission is not the same in all patients, the removal of the greater saphenous vein (gsv) is considered a standard treatment according to the guidelines. this treatment leads to unnecessary destruction of the great saphenous vein and failure to correct the pathology in patients whose reflux exited the gsv along its transmission pathway. according to this issue, in this study, the investigators intend to investigate the different pathways of reflux transmission in chronic venous insufficiency patients who are candidates for gsv ablation/stripping because of saphenofemoral junction insufficiency according to the ultrasonographic exam. this cross-sectional study will be conducted with a descriptive-analytical approach on approximately 50 participants. before surgery, patients are subjected to ultrasonographic mapping to check the pathway of reflux transmission and their related information is recorded. other demographic information will also be recorded in the relevant checklist. finally, the data will be analyzed in spss software.

Eligibility criteria:
inclusion criteria: * age\>18. * chronic venous insufficiency with a clinical grade of 3 (varicosity) or more. * documentation of saphenofemoral junction insufficiency on doppler ultrasound performed by a radiologist. * patient consent. exclusion criteria: - history of dvt

Keywords: venous insufficiency reflux ultrasonographic mapping saphenofemoral junction
prom collected via a webapp versus a touch screen solution among patients with sle

Conditions: Systemic Lupus Erythematosus

Summary: a randomised, within-participants cross-over design trial including 34 patients with systemic lupus erythematosus. the participants will be randomised to data registration of patient reported outcome measures (prom) through the danbio webapp and thereafter via the outpatient touchscreen or vice versa.

the aim of this trial is to evaluate whether electronic reporting of proms through the danbio web application (webapp) is comparable to the outpatient touchscreen among patients with sle. the trial is a randomised, crossover, agreement study where 34 patients with sle from the department of rheumatology at aalborg university hospital will be included and randomised in ratio 1:1 to: * group 1: proms are reported through the danbio webapp; thereafter, the touchscreen. * group 2: proms are reported through the touchscreen; thereafter, the danbio webapp. there will be a wash-out period of 1-2 day between the two registrations to minimise carryover bias.

Eligibility criteria:
inclusion criteria: * diagnosed in danbio with sle * experience with the prom questionnaires in danbio (≥ 1 previous assessments) exclusion criteria: * inability to provide informed consent or to comply with the study protocol * diagnosis of sle of ≥ 12 months * does not have access to a device that can run the danbio webapp
physical exercise prehabilitation program in metabolic surgery

Conditions: Obesity and Overweight; Bariatric Surgery; Prehabilitation; Exercise; Physical Fitness; Six Minute Walk Test

Summary: the goal of this clinical trial is to learn if an exercise program before bariatric surgery works to treat obesity, could improve physical condition and weight loss before bariatric surgery and induce a lifestyle behavior change. the main questions it aims to answer are: * does a supervised exercise program lead to improved physical condition prior to bariatric surgery? * does a supervised exercise program prior to bariatric surgery lead to reduced surgery related complications? * does a supervised exercise program prior to bariatric surgery lead to maintained lifestyle changes after surgery? participants will: * receive either no training program or physical exercise training program twice a week, supervised by a physical therapist, for a duration of 8 weeks. * have their fitness measured at the start and at the end of the 8 weeks, measured with a six minute walking test. * fill in a survey on their perceived quality of life and exercise habits at the start of the trial, and at 1 year after surgery.


Eligibility criteria:
inclusion criteria: * adult patients (≥18 years) * body-mass-index (bmi) 40 kg/m2 or higher, or 35 kg/m2 or higher with the presence of at least one comorbidity (type 2 diabetes, high blood pressure, heart and/or vascular diseases, obstructive sleep apnea (osa), dyslipidemia, or arthritis). * primary bariatric patients; without previous bariatric surgery. for inclusion the investigators will follow the national guidelines on metabolic surgery. exclusion criteria: patients with: * mobility problems (patients who are not able to exercise) * cognitive disabilities * illiteracy (patients who are not able to read and understand the language of the country where the study will be performed)
effectiveness of fissure sealant and topical fluoride application in preventing dental caries

Conditions: Dental Caries

Summary: nearly half of the 12-year-old children in china have dental caries (tooth decay) and most of the lesions are in the fissures of the first permanent molars. this study aims to investigate the effectiveness of three methods in preventing fissure caries in permanent teeth in chinese children, namely resin fissure sealant, sodium fluoride varnish, and silver diamine fluoride solution. the cost-effectiveness of these methods will also be compared. about 400 children, aged 8 to 9 years, will be recruited. clinical examination of the children will be conducted in school using portable dental lights and instruments to identify teeth that need caries prevention. the children will be randomly allocated to one of the three test or the control groups. treatments will be provided in the study primary schools according to standard clinical protocols. follow-up examinations will be carried out every six months for 30 months to assess whether the preventive methods are successful, i.e. no dental caries develops in the treated teeth. the findings of this study will be of great value to dentists and public health authorities in deciding on the most appropriate dental caries prevention programme for school children in china and other developing countries.


Eligibility criteria:
inclusion criteria: * school children in good general health * have at least one permanent first molars that has deep occlusal fissures, or fissures with signs of early caries exclusion criteria: * children with major systemic disease or taking long-term medications * not cooperative or refuse dental treatments

Keywords: tooth decay fluoride sealant prevention
tirofiban plus intravenous thrombolysis in acute anterior choroidal infarction or paramedian pontine infarction

Conditions: Acute Anterior Choroidal Infarction (ACI); Paramedian Pontine Infarction (IPP)

Summary: titacippi (tirofiban with intravenous thrombolysis in acute anterior choroidal infarction \[aci\] and paramedian pontine infarction \[ipp\]) study aimed to evaluate the efficacy and safety of simultaneous infusion of tirofiban with intravenous thrombolysis (ivt + tirofiban group) compared to ivt alone (ivt alone group) in patients with aci or ppi. titacippi study is a retrospective, single-center observational study conducted from march 01, 2014, to december 31, 2022.

aci and ppi are frequently associated with clinical fluctuations, characterized by recurrent transient more or less regressive stereotyped episodes of focal motor deficits affecting the face, arm, and leg, and finally with a risk of lasting neurological worsening that can lead to definite residual neurological disability. these ischemic strokes (aci and ppi) are not very sensitive to ivt, thus 26% to 48% will experience neurological aggravation despite the administration of this treatment. studies in asia have shown a possible clinical benefit of simultaneous infusion of tirofiban with ivt in patients with ischemic stroke of atheromatous or microatheromatous origin without additional bleeding risk. to date, no studies have tested the efficacy of simultaneous infusion of tirofiban and ivt in the well-defined subgroup of aci and ppi and a non-asian population.

Eligibility criteria:
inclusion criteria: * patients aged ≥ 18 years with aci or ppi between march 01, 2014 and december 31, 2022. * patients hospitalized in the stroke unit of centre hospitalier sud francilien in the acute phase of their ischemic stroke (flair negative on the pre-treatment brain mri allowing ivt). * patients with nihss ≥ 2 on admission * patients treated with ivt * for the experimental group: patients treated with tirofiban at 0.4 μg/kg/min with the start of infusion within 1 hour of ivt initiation. * patients with post-treatment brain mri within 24-36h. exclusion criteria: * patients with contraindications to ivt (cardiac, thoracic or digestive surgery less than 14 days old, thrombocytopenia \< 100,000/mm3, etc.). * absence of mri as initial imaging. * less than 24 hours of continuous infusion of tirofiban. * patients at high risk of cerebral hemorrhage: severe microangiopathy (fazekas score 3), microbleeds \> 5, or leptomeningeal hemosiderosis suggestive of amyloid angiopathy. * patients with pre-stroke mrs ≥ 3. * patients informed of the research and objecting to the collection of their data.

Keywords: anterior choroidal infarction paramedian pontine infarction intravenous thrombolysis tirofiban
characterizing breast cancer with 68ga-fapi pet/ct (pfb-01)

Conditions: Breast Cancer

Summary: fibroblast activation protein (fap) is overexpressed in cancer-associated fibroblasts (cafs), which constitute a major proportion of cells within the tumor microenvironment, especially in breast cancer. 68ga-fapi has been developed as a tumor-targeting agent. this prospective study is going to investigate the performance and value of 68ga-fapi pet/ct in patients with breast cancer.

breast cancer is a complex, heterogeneous disease comprising numerous distinct biological subtypes characterized by variant pathobiological features and clinical behaviors. 18f-fluorodeoxyglucose (18f-fdg) pet/ct, an essential imaging modality in the characterization of metabolism within the tumor, has successfully evolved in the diagnosis, staging, and assessment of treatment response in patients with breast cancer. cancer-associated fibroblasts (cafs) are a crucial component of the tumor stroma with diverse functions. fibroblast activation protein (fap), a type ii membrane-bound glycoprotein from the dipeptidyl peptidase-4 family, is highly expressed in the cafs of several epithelial carcinomas, including breast cancer, coupled with relatively low expression in normal tissue. gallium-68 (68ga)-conjugated fap inhibitor (fapi), a new radiotracer targeting fap, has been developed for targeting fap and tumor-stromal visualization. with its fast renal clearance and high tumor-to-background ratio, 68ga-fapi has been successfully validated in multi-types of tumors. this study aims to evaluate the performance and value of 68ga- fapi pet/ct in patients with breast cancer.

Eligibility criteria:
inclusion criteria: * age 18-80 years old; * newly diagnosed bc confirmed by biopsy or with bi-rads category 4c or 5 lesions by us or mg; * bc clinical stagect1-3 cn0-3 m0; * no prior treatment for bc. exclusion criteria: * pregnancy; * breastfeeding; * patients who were unwilling to undergo pet/ct scans.
removable partial dentures made of peek

Conditions: Tooth Loss

Summary: as part of the clinical study, 25 patients each were provided with removable partial dentures with clasps made of peek in two centres (university hospital heidelberg, department of prosthodontics and university hospital for dental prosthetics innsbruck). the patients were examined over a period of 3 years for the number and type of technical or biological complications and questioned about their oral health-related quality of life.


Eligibility criteria:
inclusion criteria: * indication for a clasp-anchored removable partial denture exclusion criteria: * minors and adults unable to give consent * pregnancy or breastfeeding * severe general illnesses * allergies or other intolerances to one of the materials used (peek, pmma) * suspicion of lack of compliance

Keywords: removable partial denture polyetheretherketone oral health related quality of life
comparison of abacavir following once-daily and twice-daily administration in hiv infected subjects

Conditions: HIV Infection

Summary: the purpose of the study is to look at the levels of the drug abacavir (abc) in blood. also, the study will look at the levels of carbovir triphosphate (cbv-tp), which is the active substance produced from abc in the bodyâ s cells which helps prevent hiv from multiplying. cbv-tp will be measured in specific blood cells. the amount of abc and cbv-tp will be looked at when subjects receive abc as a 300mg dose twice a day and compared with the levels when they receive abc as a 600mg dose once a day.


Eligibility criteria:
inclusion criteria: * healthy adults , inclusively. * documented hiv-1 infection (documented by historical data or current validated assay). * undetectable viral load. * currently on an abc-tablet containing regimen for at least 8 weeks. * willingness to temporarily switch abc schedule from bid to qd, or vice versa, for 11 days. * weigh between 40-100kg, inclusive. exclusion criteria: * subjects who are receiving tenofovir. * previous study participation in other experimental drug trial(s) within 30 days before the screening phase of the study. * subjects who currently regularly take drugs-of-abuse, with the exception of cannabinoids. * subjects who cannot refrain from taking herbal remedies during the course of the study. * subjects who regularly consume more than an average amount of alcohol per day. * poor general health preventing fasting or blood sampling. * subjects who are not able to discontinue use of hydroxyurea, mycophenolate or ribavirin for 14 days prior to entering the study until discharge from the study. * an unwillingness of a male subject to abstain from sexual intercourse with women of childbearing potential or an unwillingness to use a condom in addition to having their female partner use another form of contraception. * the subject is pregnant or nursing an infant. * history of symptoms consistent with a hypersensitivity reaction to abc. * positive hcv antibody or hepbsag (hepatitis b surface antigen).

Keywords: human immunodeficiency virus hiv abacavir regime abc
pre-emptive paracetamol for prevention of intraoperative shoulder tip pain

Conditions: Cesarean Section

Summary: the aim is to determine the efficacy of paracetamol in reducing the incidence and severity of intraoperative shoulder pain in patients undergoing cesarean section.

pregnant females scheduled for cesarean section under spinal anesthesia will be enrolled . two groups of patents will be recruited . the study group will receive paracetamol pre operative .

Eligibility criteria:
inclusion criteria: * healthy pregnant women (asa ii) having singleton pregnancy at term (≤ 37 weeks of gestation) aged between 18 and 40 years. exclusion criteria: * patients having allergy to study drug, * gestational diabetes * cardiovascular or biliary disorders * asthma * renal impairment * preeclampsia * any chronic pain condition or trauma in the shoulder, forearms or upper limbs * patients with any contraindication to sa were excluded from the study.

Keywords: shoulder tip pain
tracheal intubation with the rigid tube for laryngoscopy- a new method

Conditions: Intubation;Difficult

Summary: this study evaluates the efficiency of the rigid tube for laryngoscopy for tracheal intubation in patients with presumed difficult airway and compare the classical laryngoscopy and this method in matter of glottis visualisation and tracheal intubation.

the rigid tube for laryngoscopy is a 15 to 30 cm long metallic tube with a bevel end and a diameter of 0.5-2.0 cm , an instrument used to inspect the larynx and surrounding areas. it resembles a rigid bronchoscope but it is shorter. when in use, it has to be attached to a light source. the hypothesis of the study stands that the rigid tube for laryngoscopy could be more efficient in tracheal intubation for difficult airway patients when the classical intubation with a curved blade laryngoscope is unsatisfactory. the retromolar approach in both sides together with bougie(intubating tube introducer) intubation is the technique of intubation used in this study.

Eligibility criteria:
inclusion criteria: * patients with criteria of anatomically difficult airway from sari (the simplified airway risk index scale) parameters analysis * patients with airway pathology which predicted difficult intubation: tumors or cervical masses, previous radiotherapy or surgery exclusion criteria: * stridor or marked laryngeal or tracheal stenosis, vocal cords polyps * emergency surgery, decompensated cardiac or pulmonary disease * grade 1 and 2a at classical laryngoscopy after cormack- lehane classification

Keywords: laryngoscopy retromolar
the china neonatal genomes project

Conditions: Newborn; Hereditary Disease; Genetic Predisposition to Disease; Defect, Congenital

Summary: the project will carry out the genetic testing of 100000 neonates in the next 5 years. the aim of the project is to construct the chinese neonatal genome database, establish the genetic testing standard of neonatal genetic diseases, and promote the industrialization of neonatal genetic disease gene testing, improve the training system for genetic counseling.

there are about 900,000 new cases of birth defects in china every year. there are a large number of hereditary diseases, such as primary immune deficiency diseases, genetic metabolic diseases and multiple malformation syndrome, etc. it is important to identify and diagnose these diseases early in life, which can optimize the treatment strategy, improve the quality of life, and achieve the purpose of accurate treatment. to improve the level of diagnosis and prevention of genetic diseases in children is conducive to the birth and education of newborn in our country. the china neonatal genome project is an important part of the china human single target genome project. the investigators plan to complete genetic testing of 100,000 newborns within 5 years, establish genetic testing standards for genetic diseases of newborns, and promote precise intervention for birth defects. the genetic counseling branch of china genetics society, the pediatrics hospital affiliated to fudan university and hundreds of hospitals in china jointly launched the chinese newborn genome project in shanghai, china. the project will carry out the genetic testing of 100000 neonates in the next 5 years. the study physician and genetic counselor will provide the consultation to families utilizing all available medical information. in the sequencing analysis of the study, this will include the medical history, physical exam, family history, standard newborn screening report. the aim of the project is to construct the chinese neonatal genome database, establish the genetic testing standard of neonatal genetic diseases, and promote the industrialization of neonatal genetic disease gene testing, improve the training system for genetic counseling.

Eligibility criteria:
inclusion criteria: * 1. both parents are of chinese origin; * 2. postnatal age less than 28 days; * 3. can be retained to at least 1ml venous blood sample; * 4. biological parent or guardian's informed consent. exclusion criteria: * 1. the nationality of one of the parents is not the han nationality or other national minorities; * 2. reluctance of parents to use genetic sequencing data for subsequent research; * 3. parents under 18 years of age or incapacitated for decision-making; * 4. subjects older than 28 days. * 5. multiple pregnancies; * 6. lack of access to biological samples from which dna can be extracted; * 7. failure to sign informed consent

Keywords: newborn hereditary disease genetic predisposition to disease defect, congenital genome sequencing exome sequencing newborn screening genetic diseases, inborn