Kornimate/medical-research-clean huggingface dataset:
taste properties of atazanavir and cobicistat

Conditions: HIV in Adults

Summary: the primary objective is to assess the taste properties of atazanavir (atv) and cobicistat (cobi) alone and in combination as well as oral test formulations containing both atv and cobi.


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * men and women, ages ≥18 years * subjects who are qualified professional sensory panelists * healthy subjects as determined by no clinically significant deviation from normal in medical history and physical assessment exclusion criteria: * any acute or chronic condition that may alter taste or smell sensory perception * any significant acute or chronic medical illness or any surgery within 4 weeks of the study drug administration * positive hiv test using an oral swab kit (such as oraquick®) to detect hiv-1 or -2 antibody
a phase 1/2 study of aurn001 in subjects with corneal edema secondary to corneal endothelial dysfunction (aba-1)

Conditions: Corneal Edema; Corneal Endothelial Dysfunction

Summary: the goal of this clinical trial is to compare different doses of aurn001 in patients with corneal edema secondary to corneal endothelial dysfunction. the main questions the clinical trial aims to answer are whether aurn001 effective and safe. participants will receive a single injection of aurn001. a comparison between low, medium, and high doses of aurn001 against the contribution of each element, cells alone and y27632 alone, will be conducted to determine the effects on corneal edema.


Eligibility criteria:
inclusion criteria: * have a diagnosis of corneal edema secondary to corneal endothelial dysfunction, requiring surgery (full- or partial-thickness endothelial keratoplasty) * bcva between 65 early treatment of diabetic retinopathy study (etdrs) letters (i.e., 0.4 logmar or approximate 20/50 snellen equivalent) and 5 etdrs letters (i.e., 1.6 logmar or approximate 20/800 snellen equivalent) exclusion criteria: * have pre-operative corneal epithelial, sub-epithelial or stromal scarring or other opacity that is paracentral/central and visually significant, but not suspected to be secondary to corneal endothelial disease with the potential to improve from treatment in the study eye * have history or presence of an ocular disease other than corneal endothelial dysfunction that could affect vision or safety assessments
prognostic factors of importance on who develops chronic low back pain

Conditions: Low Back Pain; Life Style; Illness Perception

Summary: the incidence of low back pain (lbp) is increasing and prognostic factors for developing lbp are unclear. based on questionnaires, different prognostic factors are being explored over time.

despite massive efforts of trying to find predictors and prevention for lbp, it remains to be clarified, why some individuals develop severely disabling low back pain while others never experience noteworthy back pain. there is no evidence that numbers of chronically affected individuals have diminished; rather, the incidence of lbp has increased continuously over the last 20 years which is also reflected in rising numbers of lumbar surgical treatments. the prevalence and burden increase with age and prevention of lbp in an aging population seems more urgent than ever. as lbp is undoubtedly a multifaceted disorder that tends to fluctuate throughout life, there is a need for longitudinal research, exploring the effect of both life style and psychosocial factors on the development of chronic low back pain. the aim of this study is to identify whether a history of low back pain during adolescence represents an increased risk of experiencing low back pain later in life.

Eligibility criteria:
inclusion criteria: this is an inception cohort based on pupils from schools in elsinore. there are no formal inclusion criteria other tan being part of this cohort exclusion criteria: * no formal exclusion criteria but inability to understand/answer our questionnaire is per se an exclusion criteria

Keywords: cohort low back pain illness perception life style
efficacy and comparative of the association beclomethasone clotrimzaol + gentamicin in patients with acne contaminated

Conditions: Folliculitis

Summary: the objective of this trial is to evaluate the comparative efficacy of the combination of clotrimazole + gentamicin + beclomethasone in study subjects with a condition of contaminated dermatosis showing bilateral symmetrical lesions.

the specific objective is to evaluate, by means of analytical propedeutics medical improvement in clinical signs and symptoms related to acne infected, the use of the association: clotrimazole, gentamicin and beclomethasone versus association: clotrimazole and gentamicin, which will first be randomized. the study should be conducted with 20 research subjects aged over 18 years, of both sexes, showing the framework of bilateral lesions infected with acne, at any stage of evolution. the study subjects will receive treatment with both products, so they can use one in each lesion chosen at random, double-blind. thus, the proven efficacy and safety and taking all possible adverse events reported, the study sponsor hopes to obtain registration with the ministry of health of this new association in the country. the association made a proposal was developed by the laboratory glenmark pharmaceuticals ltd..

Eligibility criteria:
inclusion criteria: * subject search of both sexes, regardless of color or social class * from age to 18, with good mental health * carriers of two outbreaks of acne contaminated * subjects who agree to return follow-up visits * research subjects who agree to participate and sign the deed of consent exclusion criteria: * subject research carriers of susceptibility to gentamicin * research subjects suffering from sensitivity to clotrimazole * research subjects suffering from sensitivity to beclomethasone * research subjects who are making use of steroids or steroidal anti-inflammatory and non-steroidal drugs or who made use of topical or oral 15 days ago * research subjects who are doing immunosuppressive treatment * research subjects with a diagnosis of eosinophilic folliculitis or pseudo-folliculitis barbae and groin * pregnant and lactating
a multi-omics study of epithelial ovarian cancer

Conditions: Epithelial Ovarian Cancer; Tumor Invasiveness; Whole Exome Sequencing; Transcriptomics; Metabolomics; Tumorigenesis

Summary: this study aims to analyze the multi-omics results between epithelial ovarian cancer (eoc) patient with different figo stages and pathological subtypes. the multi-omics profiles include whole exome sequencing, analysis of transcriptomics and metabolomics. a comprehensive multi-omics will reveal the invasiveness and tumorigenesis of eoc.


Eligibility criteria:
inclusion criteria: * confirmed primary epithelial ovarian cancer * signed an approved informed consents * feasible for biopsy exclusion criteria: * not meeting all of the inclusion criteria
diagnostic accuracy of diagnodent compared to icdas ii

Conditions: Caries; Initial

Summary: there is a paradigm shift in conservative dentistry by substituting the surgical model with the medical model of treatment. early detection of initial carious lesions will aid in clinical decision making during management ; either no care advised, preventive care advised or operative care advised. according to recent systematic reviews meticulous visual examination using icdas ii presented a substantial level of reproducibility and accuracy for assessment of carious lesions and was considered the reference for clinical visual assessment . however, visual examination is subjective and is highly dependent on the dentist's skills and experience, with high specificity and low sensitivity. new devices have been developed to detect and quantify incipient demineralization. besides visual detection systems, laser fluorescence assessment can be considered a suitable method. in vitro data suggested that the visual examination and fluorescence method have similar accuracy to detect initial carious lesions.

this study will be conducted to evaluate the diagnostic accuracy of laser fluorescence device (diagnodent) compared to to visual examination (icdas ii) in detection of incipient carious lesions for decision making during caries management

Eligibility criteria:
inclusion criteria: * non cavitated white spot lesions. * patient compliance exclusion criteria: * cavitated lesions. * medically compromised patients. * enrollment in another clinical trials.
personalized prospective study evaluation of the efficacy and safety of noninvasive neuromodulation of tms in subjects with catatonia

Conditions: Catatonia; Schizophrenia; Schizo Affective Disorder; Bipolar Affective Disorder

Summary: evaluation effectiveness and safety of tms in subjects with catatonia

non-pharmacological strategies for influencing brain structures show great potential, particularly transcranial magnetic stimulation (tms), which allows targeting specific areas of the brain and activating neuroplastic processes that contribute to the restoration of lost functions. according to study hypothesis, therapy for catatonia is possible through the stimulation of the dorsolateral prefrontal cortex (dlpfc), given its accessibility and role in the syndrome's development because. it has been established that a key process in the pathogenesis of catatonia is the disruption of the structural-functional connectivity and activity of several regions within the fronto-temporal network the design of the study involves following stages: * diagnostic stage and randomization * two personalized stimulation protocols (high- and low-frequency delivery of magnetic pulses) with placebo control * initial analysis of the effectiveness of protocols after 10 sessions of stimulation, followed by the transfer of all patients, including the placebo group to the most effective protocol. * the stage of active neuromodulation of 20 sessions (4 weeks) according to the protocol of effective stimulation regiment * final analysis of the effectiveness after 20 sessions of tms, as well as after 1 and 6 months

Eligibility criteria:
inclusion criteria: verified diagnosis of schizophrenic or affective spectrum (schizophrenia, schizoaffective disorder, bipolar disorder, major depressive disorder) patient's ability (possibly accompanied by caregivers) to undergo diagnostic and therapeutic procedures; the presence of residual catatonia in the form of such psychomotor anomalies as: * disorganisation of thinking with speech disturbance with verbigerations and/or sperrungs * hypo- and hyperkinetic psychomotor phenomena; * substupor without disturbance of consciousness; * elective mutism; * echo phenomena (echolalia and/or echopraxia); * phenomena of "wax flexibility" * speech and behavioral stereotypy * pathetic exaltation phenomena * the phenomenon of irritative asthenia * dysuric phenomena (monotonous activity and rigidity of affect) exclusion criteria: * patient's refusal to participate in the study * acute hallucinatory-delusional symptoms * suicide risk * a patient taking prohibited therapy products * neuroleptic complications of antipsychotic therapy * irritative asthenia * dysuric phenomena by the type of monotonous activity and rigidity of affect
individualized obesity pharmacotherapy

Conditions: Obesity

Summary: the researchers are trying to identify the specific characteristics (phenotypes) that may be useful to help select the right medication for weight loss.

all participants will be phenotype and participants will randomized to randomly assigned medications vs phenotype guided medications for obesity. all participants will receive a standard intense lifestyle intervention.all participants will be seen at 4 and 12 weeks. at the 12-week visit, participants will be unblinded to their "obesity-related phenotype" and they could contact their physician to continue a fda-approved medication as part of clinical care. study team will prospectively follow the patients' weight, waist circumference and use of obesity medications every 3 months for 1 year.

Eligibility criteria:
inclusion criteria: * adults with obesity (bmi \>30 kg/m2); these will be otherwise healthy individuals with no unstable psychiatric disease and controlled comorbidities or other diseases. * gender: men or women. women of childbearing potential will have negative pregnancy tests within 48 hours of enrollment and before each radiation exposure. exclusion criteria * abdominal bariatric surgery * positive history of chronic gastrointestinal diseases, or systemic disease that could affect gastrointestinal motility, or use of medications that may alter gastrointestinal motility, appetite or absorption, e.g., orlistat, within the last 6 months. * significant untreated psychiatric dysfunction based upon screening with the hospital anxiety and depression inventory (had), and the questionnaire on eating and weight patterns (binge eating disorders and bulimia). if such a dysfunction is identified by an anxiety or depression score \>11 or difficulties with substance or eating disorders, the participant will be excluded and given a referral letter to his/her primary care doctor for further appraisal and follow-up. * hypersensitivity to any of the study medications. * no contraindications to all fda-approved medications

Keywords: pharmacological obesity management individualized
prenatal affective cognitive training to reduce the risk of postpartum depression (pact)

Conditions: Postpartum Depression; Emotional Regulation; Cognitive Function 1, Social; Pregnancy Related; Mother-Child Relations

Summary: many pregnant women face the risk of experiencing depression after giving birth, especially if they've previously dealt with depression. the goal of this study, is to test if our newly developed prenatal affective cognitive training (pact) intervention, can decrease the likelihood of post partum depression. in the study, 226 pregnant women, some of whom are considered high risk due to past mental illness or psycho-social risk factors, will participate. the high-risk women will be divided into two groups. one group will undergo the pact training, which involves computer and virtual reality exercises spanning five weeks, designed to improve mood and emotional regulation. the other group will receive usual care. the study also involves a low-risk group (n=146), although these individuals are not part of the intervention trial but are merely followed up with the same assessments for background comparisons.the main aim is to observe whether the women who undergo pact intervention are less prone to depression after childbirth compared to those who do not. this study has potential to offer a simple, non-invasive method to bolster mental health in expectant mothers, which could also positively impact their infants.


Eligibility criteria:
inclusion criteria for general pregnant population: * second or third trimester pregnancy. * age ≥ 18 years. * ability to speak and read danish. inclusion criteria for high-risk pregnant group: * either: * negative cognitive bias in emotional reactivity to infant distress (cut-off \> 96 on a scale from 0-100). * high-risk status according to the antenatal risk questionnaire (anrq) which means: * personal history of severe mental illness. * experienced childhood emotional, physical, or sexual abuse. * total score on psycho-social risk factors is above the cut-off (\> 23). inclusion criteria for low-risk pregnant group: * absence of a personal or family history of mental illness. * absence of negative bias. * three or fewer of the additional risk factors mentioned above. general exclusion criteria: * schizophrenia. * current substance use disorder. * score of 9 or more on the hamilton depression rating scale-6 items (hdrs-6), indicating moderate depression. * pregnant women diagnosed with a personality disorder (note: they will still be included at baseline and follow-up after birth but will be excluded from randomization).
expressive writing and adjustment to metastatic breast cancer

Conditions: Metastatic Breast Cancer

Summary: we are doing this study to see if writing about life experiences helps women adjust to breast cancer that has spread. we will compare two groups. one group will write about their breast cancer experience. the other will write about their daily activities. what we learn from this study may help us to find new ways to help women cope with breast cancer that has spread.


Eligibility criteria:
inclusion criteria: * women with stage iv breast cancer * receiving cancer care at memorial sloan-kettering cancer center * at least 18 years of age * can speak, read, and write in english * in the judgment of consenting professionals able to provide informed consent * score of 4 or higher on the distress thermometer (established cutoff score for probable distress; see jacobsen et al., 2005) exclusion criteria: * significant psychiatric or cognitive impairment (dementia/delirium, retardation, psychosis) that in the judgment of the investigators will preclude providing informed consent and participating in the intervention * currently engaging in expressive writing (e.g., journal writing that involves expressing one's feelings) on a daily basis * currently participating in intervention trials with similar endpoints • male

Keywords: breast cancer
teach intubation by novices in anaesthesiology

Conditions: Learning Problem; Larynx

Summary: comparision of direct laryngoscopy and video laryngoscopy to learn successful tracheal intubation by novices in anaesthesiology

video laryngoscopy has been recommended as an alternative during difficult conventional direct laryngoscopy using the macintosh blade. however, successful visualisation of the larynx and tracheal intubation using some of the indirect laryngoscopes or video laryngoscopy requires hand-eye coordination. to best of our knowledge in the current literature there are no data how is the best educative way to learn successful tracheal intubation by novices in anaesthesiology.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * capacity to consent * present written informed consent of the research participant exclusion criteria: * age \<18 years * lack of consent * inability to consent

Keywords: tracheal intubation, learning technique, laryngoscope
pancreaticogastrostomy versus pancreaticojejunostomy in reconstruction after cephalic duodenopancreatectomy

Conditions: Pancreatic Cancer; Pancreatic Anastomotic Leak

Summary: pancreaticoduodenectomy is the standards surgical procedure for various malignant and benign disease of the pancreas and periampullariy region. during the recent years, mortality rate of pancreaticoduodenectomy has decreased to 5% in specialized centers. although, this procedure still carries considerable morbidity up to 40%, depending of definition of complications. pancreatic fistula remains a common complication and the main cause of other morbidities and mortality. pancreaticojejunal (pj) anastomosis is the most often used method of reconstruction after pancreaticoduodenectomy. several technique modifications such as placement of the stents, reinforcement of anasomosis with fibrin glue, pancreatic duct occlusion and pancreaticogastrostomy (pg) type of anastomosis was used in order to decrease pancreatic fistula rate. since, some retrospective studies showed better results with some technique, several meta-analyses did not show any advantage of those various modifications. it was shown that the higher risk of pancreatic fistula was noticed in patients with soft residual pancreas and small diameter of pancreatic duct. there is only one randomized study in the literature dealing with this problem. this study did not reveal any significant differences between pg and pj in patients with soft pancreas and small duct. in order to investigate once more this important issue, the researchers conducted randomized multicenter controlled trial.


Eligibility criteria:
inclusion criteria: * patients undergone cephalic duodenopanceatectomy * soft pancreas * small diameter of the pancreatic remnant exclusion criteria: * age bellow 18 and under 80 * prevous pancreatic surgery * pregnancy * psychosis

Keywords: pancreatic cancer periampulary cancer pancreaticogastro vs pancreaticojejuno anastomosis
the early rehabilitation program in post-lt pts

Conditions: ICU-acquired Weakness

Summary: the purpose of this study is to determine whether an early rehabilitation program for immediate liver transplant patients is safe and effective in preventing critical care illness and intensive care unit acquired weakness.

patients with liver transplantation (lt) have poor general condition before surgery and require icu care for a certain period. for those patients, the side effects of icu care such as intensive care unit-acquired weakness (icu-aw), critical illness polyneuropathy (cip) are well known. therefore, we access the safety and efficacy of early rehabilitation program (erp) in liver transplant recipients. patients were retrospectively selected for the pre-erp group (2014.05-2014.10) and for the post-erp group (2015.10-2016.03). during the period of 6 months, 136 patients and 100 patients underwent lt, and 65, 62 patients were enrolled after exclusion. forty patients from the each group were compared after propensity score matching (psm).

Eligibility criteria:
inclusion criteria: * immediate post liver transplant patients exclusion criteria: * patients who transferred to sub-icu within 72 hours re-liver transplantation case wound, mental problem post op bleeding unstable vital

Keywords: liver transplantation rehabilitation icu acquired weakness
a study comparing imatinib and imatinib/pegylated interferon in chronic myeloid leukemia

Conditions: Health Care Quality; Health Care Evaluation

Summary: patients with chronic myeloid leukemia in imatinib induced chr are randomized between imatinib 400 mg daily and imatinib 400 mg daily + pegintron 30 ug weekly. primary endpoint: to compare at 12 months between the treatment arms the rate of major molecular response (=99,9% tumour reduction) at 12 months

130 patients registered, 112 randomized. 56 pats in each treatment arm. 12 months study duration. rate of major molecular response was at 12 months 53 vs 82 % (p=0.002) in favour of the combination arm.

Eligibility criteria:
inclusion criteria: chronic myeloid leukemia in imatinib induced complete hematological remission. intermediate/low risk, ecog \< 2 exclusion criteria: les than chr after 3 months imatinib high risk more than 6 months from diagnosis ecog \> 2 pregnancy -

Keywords: chronic myeloid leukemia, imatinib, interferon
evaluation of the efficiency and complications of the consequtive proning in covid -19 icu

Conditions: Acute Respiratory Distress Syndrome; COVID-19 Respiratory Infection

Summary: thirty -one confirmed severe acute respiratory syndrome coronavirus 2 (sars-cov-2 ) infected patients with acute respiratory distress syndrome (ards) and placed in prone position(pp) for 3 times (pp1, pp2, pp3)consecutively will be included. arterial blood gases (abg), partial pressure of arterial oxygen/ fraction of inspired oxygen (pao2/fio2 ) ratios, partial pressure of carbondioxide (paco2), positive end expiratory pressure (peep), and fraction of inspired oxygen (fio2) values will be recorded before (bpp), during (dpp)and after (app) every prone positioning. eye, skin, nerve and tube complications related to prone positions wll be recorded


Eligibility criteria:
inclusion criteria: a positive test result for sars-cov-2 rna through nasopharyngeal swab and underwent three subsequent prone positions for 16 hours will be enrolled the study. - exclusion criteria: negative test result for sars-cov-2 rna -

Keywords: prone position intensive care unit