Kornimate/medical-research-clean huggingface dataset:
treatment results and health care consumption from a web-based support system in behavioural childhood obesity treatment

Conditions: Childhood Obesity

Summary: this study aims to evaluate if a web-based support system with daily self-monitoring of weight, use of an activity measuring wrist-band, and communication between the clinic and the parents gives better results on degree of obesity compared with usual care. changes in bmi standard deviation score (sds) are compared between usual care (control) and usual care with complementary web-based support system (intervention).

in this study children with obesity will be randomized to either usual care according to regular routine (control) or to usual care plus a web-based support system (intervention). based on previous reviews on mobile health and obesity in combination with the investigators' experiences of childhood obesity treatment components were identified which the researchers hypothesize are of major importance for a web-based system for childhood obesity treatment: frequent self-monitoring of weight and physical activity, goals for weight loss, and feedback from the treatment team. the system is based on a smart phone application connected to a scale and an activity measuring wrist-band. data is automatically transferred from the accessories to the smart phone, where data is presented graphically. the data is further transferred to the clinic for support and communication between the clinic and the parents. the randomization will be done at the start of individual treatment and will last for 12 months. the main aim is to evaluate if use of the web-based support system will give better results on degree of obesity compared with usual care.

Eligibility criteria:
inclusion criteria: * obesity according to international obesity task force (iotf) * swedish speaking parents * parents able to use a smart phone * patients new in treatment or in treatment during the past 9-15 months with a decrease of bmi sds with ≤0.25 exclusion criteria: * diagnosed with or undergoing assessment of neuropsychiatric disorder * hypothalamic obesity * pharmacological treatment that could intervene the obesity treatment

Keywords: mobile health self-monitoring behavioural treatment
pulmonary rehabilitation post-covid-19

Conditions: COVID-19

Summary: the main objective of this pilot study was to evaluate the feasibility, safety, and satisfaction of a remote interdisciplinary pr program delivered using two exercise approaches (video conference and self-directed) on the recovery of long-term post-covd-19 outcomes. the specific aims were i) to evaluate the effect of each of the approaches on patients': 1) lung capacity, 2) dyspnea and fatigue, 3) exercise capacity, 4) physical function, 5) participation, and 5) hrqol.

this pilot study used a two-arm randomized pre- and post-trial design to evaluate the feasibility, safety, and satisfaction of a remote interdisciplinary pr program, delivered using two exercise approaches (video conference and self-directed), on the recovery of long-term post-covd-19 outcomes (≥ 3 months after infection). group one (video conference): participants were asked to follow the exercise program with a small group of peers (2 groups/6 participants each) in a zoom meeting 3 times a week/45 min each (including 5 min before and 10 min after the meeting for free talk-chat between the participants; e.g. questions and perceptions). the therapist organized and led the zoom meetings to resolve general questions (e.g. equipment, platforms, etc.). group two: participants were asked to follow the exercise program 3 times a week/30 min each while watching a pre-recorded video created by the research team and uploaded on youtube. patients were asked to wear the finger pulse oximeter at all times while exercising, so that they could control their pace while avoiding exceeding target values (hr and spo2). they were also asked to record their hr and spo2 values before and after participation in every session of the exercise program in a diary. all participants from both groups could contact the therapist at any time during the study if they had questions or concerns. they also received a follow-up phone call once a week from the therapist.

Eligibility criteria:
inclusion criteria: * post-covid-19 ≥ 3 months after infection. * mild to severe persistent respiratory symptoms * access to a smart phone, tablet or computer, and home internet exclusion criteria: * history of neurological disease or mental illness * inability to ambulate independently without supervision * inability to complete basic tasks on a smart phone or tablet * did not return calls after the initial contact

Keywords: long covid-19 persistent respiratory symptoms
the resilience alliance

Conditions: Secondary Traumatic Stress

Summary: the resilience alliance is a skill-based staff development intervention for child protective staff that focuses on improving job satisfaction, resilience, optimism and social support, while decreasing attrition, stress reactivity and burnout. the investigators believe that the intervention will enhance the capacity of child welfare workers to care for themselves, which will result in them providing better care for the children and families involved with the child welfare system. the resiliance alliance will be implemented in two child protective offices, manhattan zone c and brooklyn zone b. staff from two additional offices (staten island zone a and brooklyn zone c) will serve as a control group. a web-based survey will be administered in the group receiving the resiliance alliance intervention prior to intervention, at completion of the intervention, and 3 months post completion. the control group will be given a two-part training (3 hours in total) on secondary traumatic stress. the control group will then be asked to complete the same survey as the intervention group.


Eligibility criteria:
inclusion criteria: * administration for children's services (acs) employees working at one of four offices: manhattan zone c, brooklyn zone b, staten island zone a and brooklyn zone c * adults aged 18 years or older * english-speaking exclusion criteria: * none
the realtime detection for individual variation of analgesic ：a comparison of sufentanil vs fentanyl

Conditions: Surgery; Individuality

Summary: purpose: this study aimed to find a quick and timely way to investigate the individual variation of efficacy of opioid analgesic in chinese patients undergoing elective surgeries. methods: 120 female patients receiving elective surgery under general anesthesia were recruited into this study. at the time of routine intravenous anesthetic induction we observe the efficacy of opioid analgesic including analgesic effect, effects on narco-trend index, sedative effect, effects on respiratory system, and aslo effects on cardiovascular system.

patients with the following diseases were excluded: known history of chronic pain, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, pregnancy or at the lactation period.

Eligibility criteria:
inclusion criteria: * aged 20-65 years * anesthesiologists (asa) physical status i or ii; * within ±20% of ideal body weight; * agreed to participate the research exclusion criteria: * history of chronic pain; * psychiatric diseases; * diabetes mellitus; * severe cardiovascular diseases; * kidney or liver diseases; * alcohol or drug abuse (according to the criteria of dsm-iv); * pregnancy or at lactation period; * disagree to participate to the research

Keywords: fentanyl sufentanil individual variation pain threshold nacro-trend index
pro-diag: improved diagnosis of prosthetic joint infections

Conditions: Prosthesis-Related Infections

Summary: implantation of joint prostheses is currently the second largest diagnosis-related group in the danish health service, and in view of the demographic development and spread of lifestyle diseases, this type of intervention is expected to continue to increase. unfortunately, 5% of patients experience significant discomforts and complications. the second most frequent and serious complication is infection. while the established laboratory analyses (culture of tissue biopsies) are good at diagnosing acute infections, they are not satisfactory to diagnose a large group of patients especially with chronic infections. this can lead to prolonged diagnosing time and even to wrong diagnosis. several studies have shown that analyses of prosthetic parts and the use of molecular biological methods for detecting infecting microorganisms can significantly improve diagnostics accuracy. the purpose of this project is primarily to demonstrate that analyses of bacterial specific dna (16s rrna genes) can confirm or rule out infection as fast (or faster) as cultivation methods. rapid clarification can promote targeted treatment and in order to demonstrate this, the trial is conducted as a randomized study. .


Eligibility criteria:
inclusion criteria: * revision of hip platelets (tha) or knee replacement (tka) on indication of likely infection exclusion criteria: * surgery within the last 4 months. the same applies to patients with short history of illness, pronounced acute symptoms and systemic response (reducing the likelihood of biofilm infection).
cyanoacrylate closure for treatment of venous leg ulcers

Conditions: Venous Leg Ulcer

Summary: venous leg ulcers (vlus) are a common wound with significant morbidity and cost, and suboptimal therapeutic options. vlus result from chronic venous insufficiency, including venous reflux and post-thrombotic syndrome. vlu can take from months to years to heal, and 54-78% recur. current therapies include wound, compression therapy, and medications. these treatments can increase the rate of healing, and reduce recurrence, however these therapies can be burdensome, painful, and ineffective, and despite these therapies, \~50% of wounds become chronic. chronic vlus can be painful, malodorous, and infected, and they often significantly limit an individual's function and mobility. an emerging therapy for symptomatic venous reflux is the closure of the culprit vein by endovenous closure with a cyanoacrylate adhesive implant. recent studies show cyanoacrylate closure (cac) to be a safe and effective treatment for varicosities resulting from symptomatic incompetent great saphenous veins. this study will evaluate the safety and effectiveness of cac for vlus.


Eligibility criteria:
inclusion criteria: 1. age ≥18 years old at time of screening; 2. venous leg ulcer; 3. venous insufficiency (\>0.5 seconds; confirmed by doppler within last 6 months); 4. abi of ≥0.9; 5. capable of understanding the study and providing informed consent. exclusion criteria: 1. previous hypersensitivity reactions to the venasealtm adhesive or cyanoacrylates; 2. acute superficial thrombophlebitis; 3. bilateral treatment 4. thrombophlebitis migrans; 5. deep venous thrombosis; 6. deep venous incompetence or occlusion in external iliac or distal veins in the affected extremity (as assessed based on spontaneity, phasicity, augmentation, pulsatility, and compressibility on ultrasound); 7. post-thrombotic syndrome; 8. acute sepsis; 9. coagulation disorders; 10. radiation or chemotherapy within 3 months of study; 11. pregnant or lactating females; 12. uncontrolled diabetes (hba1c \>10%); 13. diabetic foot ulcers; 14. current use of systemic anticoagulation; 15. previous treatment of target vein; 16. tortuous veins; 17. current participation in another interventional study, or participation within 30 days prior to screening; 18. inability to tolerate compression, or to receive endovenous treatment.
national registry of igg4-rd in china

Conditions: IgG4-Related Disease

Summary: the aim of this study is to establish a nation-wide cohort study of igg4-related disease (igg4-rd) in china. methods: all the patients fulfilling diagnostic criteria of igg4-rd (2011) would be enrolled from multi-centers around china. a online database system has been established. endpoints: the primary endpoint is to investigate the clinical manifestations of chinese igg4-rd patients; the secondary endpoints including the demographic features,laboratory characteristics, immunological tests, imaging and pathological features, in addition, the treatment and prognosis of the disease.

this is a multicenter registry study of igg4-rd patients. newly diagnosed igg4-rd patients will be recruited from allover the china. inclusion criteria: patients with definite, probable, or possible igg4-rd according to the 2011 comprehensive diagnostic criteria for igg4-rd will be recruited. exclusion criteria: patients with malignancy or other autoimmune diseases are excluded. the data will be uploaded through the platform of chinese rheumatology information platform. demographic data, initial symptoms, disease duration, history of allergy, and physical examination, organ involvements, laboratory findings, radiological and pathological results, as well as treatment, side effects will be recorded. this study was approved by the medical ethics committee of pumch (beijing, china). all patients will signe informed consent. statistical analysis: all parameters are described in the standard summary statistics, including mean, standard deviation, minimum, and maximum. all statistical analyses will be performed by spss. endpoints: the primary endpoint is to investigate the organ involvements of chinese igg4-rd patients. the secondary endpoints including the demographic features,laboratory characteristics, immunological tests, imaging and pathological features, in addition, the treatment and prognosis of the disease.

Eligibility criteria:
inclusion criteria: * conforming to the diagnostic criteria of igg4-rd (2011); exclusion criteria: * excluding other mimicing igg4-rd, including tumors, vasculitis and sarcoidosis.

Keywords: registry; cohort study; igg4-related disease
multimodal instrumented assessment of post-stroke elbow

Conditions: Spasticity, Muscle; Stroke; Upper Limb

Summary: the proposed clinical trial will employ the neuroexos elbow module (neem), an active robotic exoskeleton, for the passive mobilization and active training of elbow flexion and extension in 60 sub-acute and chronic stroke patients with motor impairments (hemiparesis and/or spasticity) of the right arm. the study protocol is a randomized controlled trial consisting of a 4-week functional rehabilitation program, with both clinical and robotically instrumented assessments to be conducted at baseline and post-treatment.

the reliable assessment, attribution, and alleviation of upper-limb joint stiffness are essential clinical objectives in the early rehabilitation from stroke and other neurological disorders, to prevent the progression of neuromuscular pathology and enable proactive physiotherapy towards functional recovery. however, the current clinical evaluation and treatment of this stiffness (and underlying muscle spasticity) are severely limited by their dependence on subjective evaluation and manual limb mobilization, thus rendering the evaluation imprecise and the treatment insufficiently tailored to the specific pathologies and residual capabilities of individual patients. to address these needs, the proposed clinical trial will employ the neuroexos elbow module (neem), an active robotic exoskeleton, for the passive mobilization and active training of elbow flexion and extension in stroke patients with motor impairments (hemiparesis and/or spasticity) of the right arm. the study protocol provide a functional rehabilitation program, with both clinical and robotically instrumented assessments to be conducted at baseline and post-treatment.

Eligibility criteria:
inclusion criteria: * upper limb spasticity due to neurological impairment; * cognitive abilities sufficient for understanding instructions; * absence of severe pain assessed as visual analogic score (vas) \< 4 (range 0-10). exclusion criteria: * unstable general clinical conditions; * inability to keep sitting posture; * tendon retractions limiting upper limb joints range of motion.

Keywords: robotics upper extremities emg
medtronic 670g insulin pump and the impact on glycemic control, quality of life, and compliance

Conditions: Type 1 Diabetes Mellitus

Summary: analyze the medtronic 670g pump on glycemic control

an analysis of the medtronic 670g insulin pump use in clinical practice and the impact on glycemic control , quality of life, and compliance

Eligibility criteria:
inclusion criteria: * age 18 or older * documented history of type 1 diabetes mellitus * 3 months continuous use of the medtronic 670g pump system * given written informed consent exclusion criteria: * less than 3 months use of the medtronic 670g pump system * taking any other medication, other than the insulin used in the medtronic 670g pump, to manage their diabetes * having medical conditions or taking medications that would preclude subject involvement or affect the outcomes being measured, in the opinion of the investigator
effect of acupuncture combined with biofeedback electrical stimulation on sui

Conditions: Stress Urinary Incontinence

Summary: objective: to investigate the clinical efficacy of acupuncture combined with biofeedback electrical stimulation on female stress urinary incontinence. methods: 90 patients diagnosed in a hospital from january 2020 to january 2021 were randomly divided into three groups a, b and c, and group a was treated with biofeedback electrical stimulation, 3 times a week for 30 minutes for 15 times. group b used acupuncture treatment, including guanyuan, qihai, zhongji, zusanli, sanyinjiao and yinlingquan, once a day, monday to friday, 30 minutes each, a total of 10 times. group c was treated with acupuncture combined with biofeedback electrical stimulation. all three groups were combined with pelvic floor muscle training. after treatment, the changes in class i, ii muscle fiber, ici-q-sf score, and urine leakage in the 1h pad test were compared.


Eligibility criteria:
inclusion criteria: * meet the diagnostic criteria of sui * aged over 18 years old and have a history of sexual life * no treatment related to sui within three months * mental illness without cognitive dysfunction, able to cooperate with examination and treatment * voluntarily participate and sign the informed consent exclusion criteria: * combined with urge urinary incontinence, uterine prolapse, vaginal anterior and posterior wall prolapse * pregnancy, postpartum lochia or abnormal vaginal bleeding * acute phase of inflammation (pelvic cavity, vagina, urinary system) * there are metal substances such as pacemakers and metal stents in the body * denervation of pelvic floor muscles (no sensation, no contraction) * coagulation dysfunction

Keywords: stress urinary incontinence acupuncture biofeedback electrical stimulation
acetazolamide (az) for management of alkalosis in bartter syndrome

Conditions: Bartter Syndrome

Summary: in this prospective controlled cross over clinical trial, the investigators aim to evaluate the efficacy and safety of acetazolamide for the management of metabolic alkalosis in children with bartter syndrome. urine and blood electrolytes will be measured before and after acetazolamide treatment. the primary end point is a change in polyuria, hypokalemia, and metabolic alkalosis.

bartter syndrome is a hereditary salt-loosing tubulopathy caused by several gene mutations encoding the sodium reabsorption in the thick ascending limb of loop of henle, with poor response to treatment. the effects of inhibition of proximal tubular reabsorption of bicarbonate by acetazolamide have not been previously studied in batter patients. the present study is designed to assess he efficacy and safety of acetazolamide for the management of children with bartter syndrome. the primary end point is change in polyuria, hypokalemia, and metabolic alkalosis. in this prospective observational crossover clinical trial, patients between ages 1 and 10 years with clinical diagnosis of bartter syndrome (hypokalemia, metabolic alkalosis, normal blood pressure, elevated urine chloride \>20 milliequivalent per liter, high serum aldosterone and plasma renin levels) will be enrolled in a 4- week clinical trial. after initial clinical and laboratory evaluations, patients will receive acetazolamide 5.0 mg/kg orally as a single daily dose and each patient will act as his/her own control. renal electrolyte and 24-hour urine output will be measured at baseline and after the 4 weeks acetazolamide treatment.

Eligibility criteria:
inclusion criteria: * hypokalemia * metabolic alkalosis * normal blood pressure * random urine chloride \>20 milliequivalent per liter (meq/l) * elevated serum aldosterone and renin levels exclusion criteria: * hypertension * history of emesis * prior use of laxatives * cystic fibrosis ofpancrease

Keywords: acetazolamide hypokalemic metabolic alkalosis bartter syndrome
clonidine to prevent implantable cardiovertor defibrillator firing

Conditions: Ventricular Tachycardia

Summary: cardiac arrest or sustained vt (ventricular tachycardia) in patients with heart disease is best treated with an icd (implantable cardioverter defibrillator). however, the icd alone is not appropriate therapy for patients with frequent vt episodes. in fact frequent shocks for vt may predict a poorer prognosis. anti-arrhythmic drugs are co-administered with icds in up to 50% of patients to prevent vt episodes, but antiarrhythmic drugs may have harmful effects. thus improved drugs to prevent vt without interfering with icd function are needed. recent data including our own suggest that clonidine may be a new therapy to prevent icd shocks. it may act centrally on sympathetic outflow and peripherally and selectively on cardiac purkinje, to suppress and control vt occurring in patients. our purpose is to test the hypothesis that clonidine reduces frequent vt better than beta blocker in patients with icds. after informed consent patients will be randomized in a single blind fashion to either clonidine or metoprolol given three times per day. other prescribed drugs may be adjusted to promote toleration of the study drug. icd interrogations of episodes of vt will be the primary endpoint. device based nips (non-invasive programmed stimulation) testing in a subset of these patients will allow mechanistic understanding of the clonidine effect. all of the procedural techniques are in place as performed clinically; preliminary data are given showing feasibility of the project.

we had wanted very commonly occurring vt episodes on icd interrogation: 5 episodes/ 3 months. we could not enroll more than 2 patients most of which have interventions to prevent episodes. thus we could not enroll patients and discontinued the study in the first year.

Eligibility criteria:
inclusion criteria: * implantable defibrillator treated patients with 5 episodes of ventricular tachycardia per 3 month period exclusion criteria: * no more than one shock/3 months * no contraindication to clonidine * non-compliance * asthma

Keywords: icd patients with 5 vts per 3 month period