Kornimate/medical-research-clean huggingface dataset:
tools for improving colorectal cancer screening rates: multimedia versus print

Conditions: Colorectal Cancer

Summary: the objective of this study is to compare the effectiveness of multimedia and print tools designed to provide patients at safety-net clinics with comprehensible information about colorectal cancer screening and motivate them to complete screening.the print and multimedia interventions were constructed with parallel content to allow valid comparison of format-related effects on knowledge and screening rates.these easy to use tools will provide under served patients at community health centers with clear and consistent messages about colorectal cancer(crc) and crc screening, delivered immediately before the patients see a doctor. specific aims 1. to determine if multimedia and print interventions that provide patients with information and motivational messages about crc screening increase screening rates above usual care. 2. determine whether showing patients a multimedia program achieves higher crc screening rates than does a print booklet with equivalent messages. 1. examine if the effects of these multimedia and print interventions on crc screening rates differ with literacy level. 2. examine if the effects of these multimedia and print interventions on crc screening differ with race/ethnicity 3. examine if these multimedia and print interventions have differential effects on knowledge relevant to crc screening.

despite the clear benefits of screening for early detection and prevention of colorectal cancer, as many as half of eligible adults remain unscreened. poor and under served populations, particularly african american and latino/hispanic adults, are at greatest risk for noncompliance with recommended tests. health education strategies developed to date have led to relatively minimal gains, resulting in little translation to routine clinical practice. this is especially true in more difficult, resource-strained practice settings, such as community health centers. the interventions in the proposed study draw on communication science to optimize message design, use communication technology to optimize message delivery and include parallel content in both print and multimedia versions to allow comparison of format-related effects on both knowledge and screening rates.the multimedia and print tools are based on patient education programs that we developed with extensive attention to theory as well as community member input.

Eligibility criteria:
inclusion criteria: * 50-80 years of age, * registered for an appointment at one of the target clinics, * speaks english or spanish. exclusion criteria: * patient has had crc screening in the past 12 months, * unable to review the study materials because of language, physical condition or literacy.

Keywords: colorectal cancer screening multimedia education print education culturally competent
the difference in presentation level of variant receptors in female breast tissue in macromastia and micromastia

Conditions: Aging

Summary: there are more and more macromastic women in taiwan, which may due to the high cholesterol foods. patients with macromastia not only suffered from physical problems but also psychological discomforts.

large breasts cause neck and back pain, irritating grooves, cut in the skin of the shoulders by the pressure of brassiere straps, breast pain, and maceration and dermatoses in the inframammary region. from a psychological point of view, excessively large breasts can be troublesome focus of embarrassment for the teenager as well as the woman in her senior years. unilateral hypertrophy with asymmetry heightens embarrassment. thus, patients seek to reduce the size of their breasts. in the human female, variant receptors were detected in epithelial cells in normal breast tissue, benign breast lesions, breast carcinoma tissue, and breast cancer cell lines2-11. the cause of the difference in breast development status is still unclear. abnormalities at the tissue receptor level may be important in the pathophysiology of macromastia. this study aimed to make clear the difference in variant receptor levels between breast hypertrophy patients and macromastia ones by examining the receptor levels in breast tissue. then, we could explore the possible etiology of mammary hypertrophy and macromastia.

Eligibility criteria:
inclusion criteria: * patients receiving reduction mammoplasty exclusion criteria: -
aeration, breathing, clamping study 3

Conditions: Preterm Infant; Birth, Preterm

Summary: delayed cord clamping (dcc) in preterm infants results in a decrease in mortality and a trend towards fewer intraventricular haemorrhages. however, preterm infants needing immediate interventions for stabilisation or resuscitation were generally clamped immediately and excluded from trials, while these infants might benefit the most of dcc. studies in preterm lambs demonstrated that delaying cord clamping beyond ventilation onset resulted in more stable hemodynamic transition. this approach was called 'physiological-based cord clamping' (pbcc). the hypothesis of this study is that pbcc in preterm infants at birth will lead to an increase in intact survival when compared to standard care. this study is a multicentre randomised controlled, parallel design, superiority trial, including preterm infants less than 30 weeks of gestation. the intervention is pbcc: stabilisation of the infant with the umbilical cord intact and only clamp the cord when the infant is stable. stable is defined as the establishment of heart rate greater than 100 bpm and oxygen saturation above 85% while using supplemental oxygen lower than 40%. in the control group cord clamping will be performed time-based: infants are clamped first (at 30-60 seconds if the clinical condition allows) and then moved to the resuscitation table for further stabilisation. the primary outcome will be intact survival at nicu discharge, defined as survival without cerebral injury (intraventricular haemorrhage ≥ grade 2 and/or periventricular leukomalacia ≥ grade 2 and/or periventricular venous infarction) and/or necrotizing enterocolitis (bell stage ≥ 2).


Eligibility criteria:
inclusion criteria: * infants born at a gestational age below 30 weeks in a participating centre. * parental consent (see 9.2). exclusion criteria: a potential subject who meets any of the following criteria will be excluded from participation in this study: * significant congenital malformations influencing cardiopulmonary transition. * signs of acute placental abruption. * anterior placenta praevia or invasive placentation (accreta/percreta). * birth by emergency caesarean section (ordered to be executed within 15 minutes). * maternal general anaesthesia during caesarean section. * twin gestation with signs of twin transfusion syndrome or twin anaemia polycythemia syndrome not treated with fetoscopic laser treatment. * multiple pregnancy \> 2 (triplets or higher order). * decision documented to give palliative neonatal care. in case of twin delivery by caesarean section it is not possible to perform pbcc in both infants. both infants will be included: the first infant will receive standard treatment and the second infant will be randomised to either pbcc or standard treatment.

Keywords: preterm infant cord clamping resuscitation
diet education program for stage i-iv colorectal cancer survivors

Conditions: Stage I Colorectal Cancer AJCC v8; Stage II Colorectal Cancer AJCC v8; Stage IIA Colorectal Cancer AJCC v8; Stage IIB Colorectal Cancer AJCC v8; Stage IIC Colorectal Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage IIIA Colorectal Cancer AJCC v8; Stage IIIB Colorectal Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8

Summary: this pilot trial evaluates the feasibility of a group diet education program for stage i-iv colorectal cancer survivors. providing a nutrition education program for colon and rectal cancer survivors may help them have better access to the tools necessary to make healthy food decisions that can impact their cancer outcomes.

primary objective: i. to describe the feasibility and acceptability of a group diet education intervention for colorectal cancer (crc) survivors at zuckerberg san francisco general hospital (zsfgh). secondary objective: i. to describe perceived barriers to healthy diet among crc survivors at zsfgh. exploratory objectives: i. to evaluate for differences in feasibility and acceptability of a group diet education program, based on sociodemographic factors such as education, food insecurity, employment, and race. ii. to explore changes in health-related behaviors pre and post intervention using a validated lifestyle score. outline: patients attend group diet education sessions over 1.5-2 hours every 2 weeks (weeks 1, 3, and 5). after completion of study, patients are followed up at 12 weeks.

Eligibility criteria:
inclusion criteria: * able to speak and read english or spanish * diagnosed with stage 1- 4 colorectal cancer within 5 years prior to study enrollment and treated with curative intent * receiving survivorship follow up care at zuckerberg san francisco general hospital (zsfgh) * able to provide written consent exclusion criteria: * currently receiving chemotherapy, biologic therapy, radiation, or immunotherapy for colorectal cancer
surgical repair of spigelian hernia in a cohort of patients

Conditions: Spigelian Hernia

Summary: repair of spigelian hernias with a tentacle shaped implant and highlighting the results of the procedure

the surgical treatment of spigelian hernias is mainly carried out with prosthetic meshes made of biocompatible material. in prosthetic repair of abdominal protrusions, mesh fixation and overlap of the mesh are source of complications. to avoid these problems, for a fixation free repair of spigelian hernias has been developed a tentacle shaped implant, that should also assure a broader defect overlap. this study should highlight in a cohort of patients the long-term results of fixation free repair of spigelian hernias carried out with tentacle mesh.

Eligibility criteria:
inclusion criteria: * patients diagnosed with spigelian hernia exclusion criteria: * patients not having spigelian hernia,
functional outcomes and hrqol in upper-extremity sarcoma patients after limb salvage

Conditions: Cancer of Muscle

Summary: this study aims to assess the functional ability and health-related quality of life (hrqol) of upper extremity sarcoma patients who have undergone limb salvage surgery.

the purpose of this study is to assess the functional capabilities and health-related quality of life (hrqol) of upper-extremity sarcoma patients who have undergone limb salvage surgery. patient hospital records are retrospectively reviewed for demographic and clinical data. the patient recruitment takes place at the outpatient clinic of the comprehensive cancer center, helsinki university hospital, and tampere university hospital. the study includes a cross-sectional assessment at six months follow-up with five validated questionnaires. a follow-up is conducted two and five years after surgery in the outpatient clinic.

Eligibility criteria:
inclusion criteria: * upper extremity soft tissue sarcoma locating in between scapula to arm * no metastasis at the time of diagnosis * undergone limb salvage surgery * a minimum of 6 months follow-up * written consent * age \> 18 exclusion criteria: * age \<18 * no limb-salvage surgery due to sarcoma * deceased
pilot study: dynamic contrast-enhanced magnetic resonance imaging(dce-mri)for assessing tumor vascularity and permeability in soft tissue sarcoma treated with preoperative radiotherapy followed by surgical resection

Conditions: Soft Tissue Sarcoma

Summary: this is a pilot study to determine the diagnostic value of dynamic contrast enhancing mri (dce-mri) in soft tissue sarcoma for assessment of tumor radiographic changes in vascular permeability and microvessel density before and after preoperative radiotherapy.

all patients have biopsy proven soft tissue sarcoma and undergo preoperative radiotherapy. dynamic contrast-enhancing mri t1-weight dce-mri will cover the whole tumor and involved lymph nodes if indicated. dce-mri is obtained before radiation starts and 4 weeks after rt completes. blood volume images are estimated by using general toft model, by which the blood flow was corrected for vascular permeability and perfusion. these images are geometrically co-registered with post-gd t1-weighted mr images and pre-op rt routine mri images are fused with the treatment planning ct. routine and dce-mri will be evaluated in each patient to determine the gross tumor volume. the quantitative parameters are determined on dce-mri for quantitative parameters in blood flow and permeability in the region of interest. dynamic images are converted into color maps reflecting ktrans, kep, ve, and mean value of each parameter.

Eligibility criteria:
inclusion criteria: 1. pathologically confirmed soft tissue sarcoma. 2. age ≥ 18. 3. ecog 0-1. 4. able to receive preoperative radiotherapy followed by surgical resection. 5. able to provide treatment consent forms that conforms to federal and institutional guidelines. 6. have adequate kidney function for safe administration of gadolinium contrast, as determined by current department of radiology mri guidelines. 7. creatinine clearance either by 24 hour collection or nomogram: creatinine clearance (cc) \> 50 ml/min is determined by 24 hour collection or nomogram: cc male = (140 - age) x (wt. in kg)/(serum cr mg/dl) x 72 cc female = 0.85 x (cc male) exclusion criteria: 1. patients have claustrophobia, iron or metal in the mri scan site or pacemaker which are contraindicated for mri scan. 2. patients have pacemaker or defibrillator and contraindicated to mri images 3. patients are allergic to gadolinium iv contrast. 4. patients have acute or chronic renal insufficiency and contraindicated to gadolinium contrast enhancing mri. 5. patient had previous radiation to the same disease site. 6. patient had chemotherapy prior to preoperative radiotherapy. 7. patients that are pregnant. patients that may become pregnant must have a negative pregnancy test prior to enrolling.
low dose human chorionic gonadotropin: influence on the endometrium

Conditions: Infertility

Summary: the purpose of the present study is to assess the influence of the administration of low dose hcg on the endometrium. the study is a randomised trial where 2 groups of patients, undergoing a gonadotropin-releasing hormone antagonist protocol for in vitro fertilization, are studied. in addition to the histological findings, by analysing the correlation of the morphological pattern and gene expression profile of human endometrium on the day of oocyte retrieval in patients of both treatment groups, the investigators want to study the implantation potential.


Eligibility criteria:
inclusion criteria: * \< 36 years on day of randomisation * fsh \< 12 in the early follicular phase * normal ultrasound scan * bmi between 18 and 29 (both inclusive) * randomisation at outpatient clinic exclusion criteria: * endometriosis ≥ grade 3 * pco syndrome * poor responder * endocrine or metabolic abnormalities

Keywords: infertility icsi hcg infertility treatment
ankle taping and functional ankle instability

Conditions: Ankle Sprains

Summary: background and purpose: ankle inversion sprains are the commonest injuries of the lower extremities. taping is routinely used after ankle sprain to support the joint and prevent reinjury. the effect of taping on functional performance in participants after ankle sprain has received little attention and generally with inconsistent findings. besides, the perception of confidence and reassurance that may come with the ankle being taped might lead to the improvement of functional mobility performance. therefore, the purpose of this study is to investigate the effects of rigid ankle tape and fibular tape on functional performance, self-efficacy and perceived stability, confidence and reassurance during functional tasks in participants with functional ankle instability. methods: this study is a randomized controlled trial. forty subjects with functional ankle instability will be recruited and randomly assigned into the rigid tape group and the fibular tape group. participants will perform functional mobility tests with and without the ankle taped. the functional tests are: figure-8 hopping test, lateral hopping test, star excursion balance test (sebt), single-leg stance and stair decent test. secondary outcome measures were self-efficacy and perception measure. statistics: two-way analysis of variance with repeated measures was used to determine the effects of intervention on each dependent variable. model effects were group, time (pre, post), and their interaction. post hoc pairwise comparisons between pre and post in each group, and independent t test between groups, were used to document the difference. the statistical significance was set at p less than 0.05.


Eligibility criteria:
inclusion criteria: 1. participants had to have sustained at least two ankle sprain from a sudden inversion trauma, at least one month prior, which resulted in pain and swelling over the lateral ligament and limping, and have at least moderate functional ankle instability 2. a score of \<27 on the cumberland ankle instability tool (cait) 3. anterior drawer test: negative 4. talar tilt test: negative exclusion criteria: 1. if they had sprained their ankle within two weeks of testing 2. had a neurological or vestibular disorder or were unable to understand the nature of the protocol and test instructions. 3. have received intervention for ankle instability 4. pi's research assistant -

Keywords: ankle taping
clinical research of tcm on pelvic inflammatory disease sequelae

Conditions: Pelvic Inflammatory Disease

Summary: the trial attempts to optimize, standardize and simplify the characteristic diagnosis and treatment program of the dominant diseases in our hospital-the sequelae of pelvic inflammatory disease, so as to make it suitable for clinical diagnosis and treatment in primary hospital.

sequelae of pelvic inflammatory disease (spid) is a common cause of chronic pelvic pain, ectopic pregnancy and infertility, which seriously affects the physical and mental health of the patients, quality of life and family happiness. western medicine for pelvic inflammatory disease sequelae is still lack of effective treatment methods, traditional chinese medicine treatment of this disease has a unique advantage, with broad prospects for development..standardized diagnosis and treatment scheme of this project on the one hand, improve and optimize the sequelae of pelvic inflammatory disease, including according to the dialectical treatment of herbal medicine combined with tcm (traditional chinese medicine enema, external application of chinese medicine intervention treatment); on the other hand, to observe the clinical curative effect and adverse reaction of traditional chinese medicine comprehensive treatment.

Eligibility criteria:
inclusion criteria: 1. patients with diagnostic criteria for the sequelae of pelvic inflammatory disease in western medicine; 2. patients conforming to the criteria of tcm syndrome differentiation; 3. age 18--60 years old, married or sexual life; 4. in this study, the voluntary participation, and signed informed consent; exclusion criteria: 1. patients who do not meet the diagnostic criteria of western medicine and traditional chinese medicine dialectical typing standard; 2. persons with acute pelvic inflammatory disease; 3. related symptoms caused by diseasesgynecological tumor，specific vaginitis, acute cervicitis, pelvic congestion syndrome, endometriosis, adenomyosis, pelvic tuberculosis etc. 4. pregnant and lactating women; 5. with severe primary disease, such as liver, kidney, heart, brain and hematopoietic system; 6. allergic to a variety of drugs or known to be allergic to the composition of the use of traditional chinese medicine; 7. patients taking part in other clinical trials; 8. suspect or do have a history of alcohol, drug abuse or according to the judgment of the researcher,other lesions or circumstances that have reduced the likelihood of entering a group or the complexity of entering a group,such as frequent changes in the working environment, the living environment is not stable,etc.
enhanced recovery in laparoscopic cholecystectomy

Conditions: Acute Cholecystitis; Gangrenous Cholecystitis

Summary: the study assesses the impact of the modified enhanced recovery protocol on the results of surgical treatment of patients with acute cholecystitis.

laparoscopic cholecystectomy (lc) is the most common surgical procedures in the world. elective lc is commonly performed as one-day surgery, while in an emergency setting of acute cholecystitis the in-hospital stay averages 4.5 days. causes of prolonged rehabilitation period are often associated with severe pain syndrome, dyspepsia and postoperative complications. the complications rate after lc is about 6% and has no tendency to decrease. the implementation of enhanced recovery after surgery (eras) programs may potentially reduce stress-associated complications and improve the quality of rehabilitation. a few retrospective studies examined their advantages and setbacks in the treatment of acute cholecystitis with encouraging results. the aim of this randomized control study is to evaluate the modified eras program for patients with acute cholecystitis.

Eligibility criteria:
inclusion criteria: * grade i and ii acute cholecystitis according to tokyo guidelines 2013 classification (tg13) * asa i and ii. exclusion criteria: * severe acute cholecystitis (grade iii on tg13); * patient's refusal to participate; * the language barrier; * transfer to the intensive care unit after surgery; * asa class ≥ iii; * conversion to open procedure; * biliary hypertension detected during preoperative examination or intraoperatively.

Keywords: enhanced recovery intraperitoneal anesthesia low pressure pneumoperitoneum cholecystitis in-hospital stay laparoscopic cholecystectomy
serum free fatty acid metabolite biomarkers of lung cancer

Conditions: Lung Cancer; Biomarkers; Fatty Acids

Summary: this study aims to evaluate the performance of serum free fatty acids as biomarkers for the identification of lung cancer.

we will compare the concentration of free fatty acids and their metabolites between patients with lung cancer and control pulmonary patients without known cancer. the diagnostic accuracy will be assessed for potential predictors.

Eligibility criteria:
inclusion criteria: * age from 40 to 80 * lung adenocarcinoma with pathological diagnosis * lung squamous cell carcinoma with pathological diagnosis * control patients should have at least one of the following criteria: (1) current or ex-smoker with at least a 10 pack-year history, (2) a first-degree relative with a history of lung cancer, or (3) a clinical diagnosis of copd. exclusion criteria: - lung cancer patient without serum sample before the initiation of treatment