Kornimate/medical-research-clean huggingface dataset:
the contact pvi study: use of tissue contact data to guide atrial fibrillation ablation

Conditions: Atrial Fibrillation

Summary: this study aims to investigate the benefit of a new impedance-based computer software application during routine catheter ablation for atrial fibrillation, to see if this information improves short and long term electrical disconnection of the pulmonary veins. this study will be a single blind prospective randomised control trial in patients undergoing af ablation. study participants will be randomly assigned to undergo parts of their pulmonary vein ablation with, and parts of their ablation without tissue contact data displayed for the doctor performing the ablation to see. the pulmonary veins will then be studied at the end of the procedure, and at any repeat procedure in the future, to look for a difference in the recovery rate of the ablations performed using contact data, compared to those ablations performed without the use of this contact data. if a reduction in tissue recovery is achieved through the use of this tissue contact data, it may lead in the future to a reduced need for repeat ablation procedures, and better outcomes for patients. the investigators hypothesise that the use of the ensite™ contact™ eci data will reduce the recovery of conduction, and promote long-term pulmonary vein isolation in patients undergoing left atrial ablation for atrial fibrillation.


Eligibility criteria:
inclusion criteria: 1. participant is undergoing de novo pulmonary vein isolation procedure. 2. participant is willing and able to give informed consent for participation in the study. 3. male or female, ≥18 years of age. exclusion criteria: 1. previous percutaneous or open surgical procedure involving the left atrium 2. pregnancy (current or currently planning)

Keywords: atrial fibrillation ablation contact
bronchoscopy for thoracic trauma patients

Conditions: Chest Trauma

Summary: the study aims to evaluate the effectiveness of bronchoscopic sputum suction in patients with severe thoracic illness-induced respiratory failure. the study will compare the outcomes of patients who receive bronchoscopic sputum suction versus blind negative pressure aspiration for sputum removal. the study will measure baseline data, postoperative blood gas conditions, and clinical parameters, such as time of invasive ventilation, total time of ventilation, hospital stay, weaning success rate, reintubation rate, ventilator-associated pneumonia incidence, and fatality rate. the study aims to determine whether bronchoscopy-assisted sputum removal is superior to blind negative pressure aspiration in improving patient outcomes.

the aim of the present randomized control trial is to assess the value of bronchoscopic sputum suction in patients with severe thoracic illness-induced respiratory failure. to decrease group differences in baseline characteristics and blood gas conditions, patients will be randomly assigned to receive either bronchoscopy-assisted or negative pressure aspiration for sputum suction, while the remaining treatment course will be the same. the study will measure major clinical indicators such as time of invasive ventilation, total time of ventilation, hospital stay, weaning success rate, reintubation rate, ventilator-associated pneumonia incidence, and fatality rate to provide strong evidence for the efficacy of each suction method.

Eligibility criteria:
inclusion criteria: * participants must be 20 years of age or older. * participants of all genders are eligible. * participants who are not in good health are not eligible. * participants with an injury severity score greater than 9 and who have chest trauma are eligible. exclusion criteria: * patients with traumatic brain injury. * patients with active pulmonary tuberculosis or other respiratory diseases with suspected contagion. * patients with poor blood clotting function or a tendency to bleed. * patients with aortic aneurysm. patients with unstable vital signs or those who cannot maintain oxygen saturation above 90% while performing the test with fraction of inspired oxygen (fio2) greater than 80% or on 100% oxygen. * immunocompromised patients. * patients with acute massive hemoptysis. * patients with pre-existing neuromuscular diseases or those at high risk for arrhythmias, myocardial ischemia, or pulmonary embolism. * patients who are unable to clearly express their willingness to sign the informed consent form. * patients who have frequent intermittent sputum suction or are unable to fast for 4 hours due to their medical condition.
prevent post-discharge hospital admissions using mobile phone app

Conditions: Surgery

Summary: the investigators aimed to assess the impact of a mobile phone application facilitating real-time visual and verbal communication on reducing emergency room admissions following circumcision.

today, communication devices make our lives easier and provide convenience in the healthcare sector. some studies have mentioned that a definitive diagnosis can be made with digital photographs and video images in children with normal findings at the time of examination, and further diagnostic tests become unnecessary . readmission to the hospital after surgery, especially in children, is a situation that increases the level of anxiety. the use of smart device applications to evaluate both the operation site and functional results after many surgical procedures has reduced the number of re-applications and anxiety levels of patients . through communication, the patient can articulate their needs to the physician, either verbally or visually, and with the assistance of the physician, navigate through this process much more smoothly. in our randomized prospective study, the investigators aimed to assess the role of a mobile phone application facilitating real-time visual and verbal communication, as well as instant information exchange, in reducing emergency room and urology policlinic admissions due to potential complications after circumcision.

Eligibility criteria:
inclusion criteria: * circumcision exclusion criteria: * hypospadias * cryptoorchidism * bleeding diathesis

Keywords: anxiety patient readmission circumcission telemedicine
comparison of voice results at 5 years of treatment of glottic squamous cell carcinoma t1 by surgery versus radiotherapy

Conditions: Glottic Carcinoma

Summary: patients with early-stage squamous cell carcinomas of the vocal cord can be treated in an equivalent way in terms of carcinology by surgery or radiotherapy. the study will be to analyse the vocal outcome at 5 years of these two types of management in order to define whether one is superior to the other on this criterion of voice quality after treatment.


Eligibility criteria:
inclusion criteria: * patients with glottic squamous cell carcinoma t1n0m0 who may benefit from treatment with exclusive radiotherapy or exclusive surgery. * patients treated for these cancers at lille university hospital and the oscar lambret centre between 2015 and 2017. * tis, t1a and t1b glottic squamous cell carcinomas according to the tnm 7th edition classification in long-term survivors. exclusion criteria: -

Keywords: glottic squamous cell carcinoma surgery radiotherapy voice
neoantigen vaccine plus anti-pd1 and chemotherapy as an adjuvant therapy for pancreatic cancer

Conditions: Pancreatic Cancer; Adjuvant Therapy

Summary: the aim of this single center, single arm and prospective study is to explore the safety and efficacy of neoantigen vaccine plus anti-pd1 and chemotherapy in postoperative adjuvant treatment of pancreatic cancer


Eligibility criteria:
inclusion criteria: 1. age ≥18 years and age ≤75 years. 2. ecog score 0-1. 3. patients with histologically confirmed pancreatic ductal adenocarcinoma, r0 resection, stage i-iii, not receiving neoadjuvant therapy. 4. adequate bone marrow and organ function: 5. patients of childbearing potential must take appropriate precautions prior to enrollment and during the study. 6. signed informed consent. 7. ability to comply with the study protocol and follow-up. exclusion criteria: 1. received antitumor chemotherapy, radiation therapy, or immunotherapy within 2 weeks prior to first vaccination. 2. the patient has a history of other tumors, except for cervical cancer in situ, treated squamous cell carcinoma or urothelial tumors (ta and tis), or other malignancies that have been treated with curative intent (at least 5 years prior to enrollment). 3. uncontrollable comorbidities, including but not limited to active bacterial or fungal infections, symptomatic congestive heart failure, unstable angina, arrhythmias. 4. hiv infection or active hepatitis b (hbv dna≥500iu/ml), hepatitis c. 5. uncontrolled coronary artery disease or asthma, uncontrolled cerebrovascular disease, or other conditions deemed ineligible by the investigator. 6. uncontrollable comorbidities, including but not limited to active bacterial or fungal infections, congestive heart failure, unstable angina, arrhythmias, etc; 7. patients with autoimmune diseases or immunodeficiencies being treated with immunosuppressive drugs. 8. pregnant or lactating women. 9. vaccination with other preventive vaccines within 4 weeks before the first administration or planned during the study period, including within 8 weeks after the last vaccination. 10. those who have had a severe allergic reaction to vaccines for other infectious diseases in the past. 11. those who may be allergic to the investigational product or any of its excipients. 12. substance abuse or inability to undergo immunotherapy due to clinical, psychological, or social factors. 13. significant weight loss (≥10%) within 6 weeks prior to enrollment. 14. any uncertain factors that may affect patient safety or compliance.

Keywords: pancreatic cancer neoantigen adjuvant therapy safety clinical efficacy
allergen challenge chamber study with single dose intranasal gsk1004723 compared with placebo

Conditions: Allergic Rhinitis

Summary: this is a placebo-controlled, 3-period crossover study to assess the efficacy and safety of two single doses of an intranasal anti-histamine gsk1004723 compared with placebo in an allergen challenge chamber in male subjects with seasonal allergic


Eligibility criteria:
inclusion criteria: * subject is healthy apart from seasonal allergic rhinitis, as determined by a physician. can have mild asthma. * male * aged 18 - 65 * weight 50kg+, bmi 19-32 kg/m2 * exhibit response to challenge chamber and skin prick test. * non-smoker * capable of giving informed consent exclusion criteria: * no nasal structural abnornmality/polyposis, surgery, infection. * any respiratory disease, other than mild asthma or seasonal allergic rhinitis * participated in another clinical study within 30 days. * subject has donated a unit of blood within 1 month * use of prescription or non-prescription drugs, including vitamins and st john's wort within 7 days of trial. * history of sensitivty to drug * history of alcohol/drug abuse within 12 months. * positive hepatitis b antibody test * positive hiv antibody test * risk of non-compliance with study protocol * perenial allergic rhinitis * administration of oral, injectable or dermal corticosteriods within 8 weeks, intranasal or inhaled within 3 weeks. * past or present disease that may affect outcome, as judge by investigator specific immunotherapy within 2 years

Keywords: allergic rhinitis proof-of-concept
a clinical trial on the effects of home-based five plus exercise training

Conditions: Intermittent Claudication

Summary: the aim of the study is to evaluate whether walking capacity in patients with intermittent claudication is improved more by home-based 5+ exercise training than by current recommendations of daily walking. the study will elucidate if such a potential effect is dependent on changes in mitochondrial respiratory capacity, blood flow or both.


Eligibility criteria:
inclusion criteria: * diagnosed with intermittent claudication secondary to vascular insufficiency * an ankle-brachial index between 0.4 and 0.9. exclusion criteria: * diagnosed with critical limb ischemia * ankle-brachial index (abi) \> 0.90 or \< 0.4 * limited exercise tolerance * warfarin or heparin usage * underwent a vascular intervention in the last 6 months * active cancer, renal- or liver disease

Keywords: mitochondria, muscle exercise blood flow velocity
self-management in type 2 diabetes patients using the few touch application

Conditions: Type 2 Diabetes

Summary: it is hypothesized that the use of the mobile phone-based self-help system fta, and with the patients as active players, will improve diabetes self-management reflected by improved glycemic control and lipids, self-care behaviours and lifestyle changes such as improved dietary habits and increased physical activity, compared with usual care. following this; it is also hypothesized that this will also lead to a reduction in overall risk for diabetes complications (expressed by reduction in e.g., 5 year absolute risk for coronary artery disease as calculated using the swedish national diabetes register's risk calculator) and in the prevalence of the metabolic syndrome (e.g., as defined by the international diabetes federation). it also hypothesized that health counselling based on ttm and cbt by a diabetes nurse, and with individualized feedback via sms from the diabetes nurse, may have an important function as a supplement to the self-help system (fta). in addition, it is hypothesized that the patients' health status and diabetes-related quality of life (hrql) will improve. the results of this study may show that a commonly used tool like the mobile phone, and also mobile phone together with health counselling, fitted into the patients' daily life, is more effective and cost-effective than standard care.

the purpose of this study is to examine the effectiveness of mobile phone-based lifestyle tools, and health counseling using tailored sms and individual phone-calls to the patients, for self-management of t2dm. maintaining daily symptom diaries (described below) by an easy way of self-monitoring appear to offer a valid and reliable way of assessing behaviours. in addition, the patients are able to view their own registrations on the smartphone, i.e. a programmable mobile phone with a touch sensitive screen. the self-help system, called the "few touch application", recently tested on 12 people with t2dm at nst, university hospital of north norway (unn), will form the basis for the patients' mobile interaction system.

Eligibility criteria:
inclusion criteria: age \>18; diagnosed t2dm \> 3 months prior to study inclusion; in case the patient is receiving one or more glucose lowering drug (e.g., metformin, sulphonylurea, glinide, α-glucosidase inhibitor, dpp-iv inhibitor, glp-1 analogue, glitazone, insulin) the treatment should be stabilized (i.e., no change in dosage the last three months prior to inclusion except for insulin treated patients who are allowed ±15% dose adjustment; hba1c \>7%; capability of understanding and filling in norwegian questionnaires; be able to use the system provided; be cognitive able to participate.
drug use and sexual risk behaviors among emerging adults in the er

Conditions: Drug Use; Sex Behavior

Summary: this project will develop a technology-augmented hiv and substance use risk reduction intervention for delivery in the emergency department, a medical setting where at-risk emerging adults who use drugs and engage in hiv-related risk behaviors are likely to present.

research regarding substance use (including illicit drugs and non-medical use of prescription drugs) and hiv-related sexual risk behaviors (hiv srbs; e.g., inconsistent condom use, multiple partners, sex while intoxicated; and prevention of injection drug use) among emerging adults (eas; ages 18-25) has generally focused on alcohol use among college students from campus settings; however, substance use and hiv (and other associated sexually transmitted infections) disproportionately occur among young people living in urban, low-resource communities, particularly individuals of racial minorities. the emergency department (ed) is a critical venue for accessing at-risk eas engaging in substance use and hiv risk behaviors. research shows high rates of substance use and hiv srbs among ea patients in the ed, yet no intervention exists for eas in this setting. the ed may be the only opportunity to intervene with these young people because eas in urban, low-resource settings often lack a primary care provider during the transition from pediatric to adult medicine, may be un-insured or under-insured, and may not be involved in a traditional college campus setting. further the use of technology (e.g., mobile phones) is relatively ubiquitous among this age group, and most prefer technology-based communication (e.g., text messaging or instant messaging via apps), therefore interventions for eas may be enhanced by this type of technology. in this phase we will test a tailored intervention for ea patients in the ed focusing on reducing substance use and hiv srbs, which will be enhanced through the use of mobile app notifications.

Eligibility criteria:
inclusion criteria: * medically stable * mentally and physically able to consent * english-speaking * between ages 18-25 * past-month substance use (including illicit drugs and/or non-medical prescription drug use) and inconsistent condom use in the past month * ownership of a smartphone exclusion criteria: * ed presentation suicidality and/or acute psychosis, being in police custody, or present with psychological distress requiring intensive social work (e.g. sexual assault) * patients with a significant other that they live with who is currently participating in study * actively participating in another study * participated in prospective and intervention development phases of the study * married * do not wish to consent to audio-taping the in-person portion of the ed-based intervention session

Keywords: emerging adults drugs hiv risky sex behaviors
intermittent oro-esophageal tube feeding using individually-customized 3-dimensional printing

Conditions: Dysphagia

Summary: the aim of this study is to test the clinical effectiveness of ioe tube using individually customized 3-dimentional printed guiding tube as an alternative to levin tube feeding when unconscious patients have no choice but tube feeding.

according to standard guideine of videofluoroscopic swallow study(vfss), patients referred to dysphagia(swallowing dysfunction)who were required to tube feeding and medically stable of vital sign, and agreed to participate. participants with swallowing dysfunction who were classified into three groups (nasogastric tube, traditional intermittent (ioe) tube, individual 3d printed guiding tube) according to vfss. both traditional ioe tube and individual 3d printed guiding tube groups will receive training about procedure prior to the first feeding. all participants will be evaluated with satisfaction for tube feeding (eortc qlq-h\&n35) in 3 days from the start day of the tube feeding. on the day of oral feeding, participants will be evaluated with the questionnaires and clinical examination. if the participant is discharged in a state maintain the tube feeding, investigated further length stay at leaving the hospital. on the 1 month, 3 month from tube feeding, the investigators will follow-up and measure the questionnaires and clinical examination.

Eligibility criteria:
inclusion criteria: * dysphagia patients to check in vfss (videofluoroscopic swallow study) * patients participating in the study agreement * oral feeding is not possible (need tube feeding) exclusion criteria: * patient to reject the participation * crico-pharyngeal incoordination * impaired esophageal peristalsis * impaired gi tract * observed esophageal reflux

Keywords: dysphagia intermittent tube individual 3d printed guiding tube
a randomized controlled trial of a web-based platform for cancer pain management

Conditions: Cancer Pain

Summary: malignant tumors are one of the major public health problems in china, and cancer pain is a common symptom in tumor patients, affecting the quality of life. in rural areas, cancer pain management is challenging due to insufficient medical resources and limitations in understanding cancer pain. investigators plan to develop a convenient patient self-reporting applet to help participants report their symptoms to primary care physicians promptly and monitor pain levels and medication in real-time. this project aims to improve the efficiency of cancer pain management, integrate cancer pain into chronic disease management, improve the quality of healthcare services for rural participants, and promote the construction of a healthy china.


Eligibility criteria:
inclusion criteria: * patients with tumors that are confirmed by pathological findings. * presence of tumor-related pain that is moderate or higher and requires intervention with morphine-based pain medication (++). * have a life expectancy of more than 6 months. * understand and sign a consent to participate in the study, or if the patient is unable to understand the study, his/her direct caregiver must have a good understanding of the study. exclusion criteria: * presence of other chronic non-cancer pain/have an unresolved pain-related condition. * moderately severe cognitive impairment/cognitive impairment. * have schizophrenia or other psychiatric illness. * neither the patient nor his/her direct caregiver can understand how to use the cancer pain management applet. * being pregnant.
observational study - ilm peeling

Conditions: Epimacular Gliosis; Macular Hole

Summary: this observational study investigates the effects of epimacular membrane peeling on the structure and function of the retina.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of epimacular gliosis * must be scheduled for ilm-peeling independently of study * must be older then 18 years of age exclusion criteria: * visual acuity \> 0,4 logmar (\< 20/50 edtrs) * other ophthalmological disorder affecting visual acuity and/or visual field and/or retinal structure

Keywords: retina gliosis macula membrane ilm
this randomized, clinical trial evaluates the efficacy of oral versus sublingual vitamin b12 supplementation in correcting early-onset vitamin b12 deficiency in adult patients using proton pump inhibitors (ppis). the primary outcome is the change in serum vitamin b12 levels over a 6-week

Conditions: Hypovitaminosis b 12

Summary: this randomized, clinical trial evaluates the efficacy of oral versus sublingual vitamin b12 supplementation in correcting early-onset vitamin b12 deficiency in adult patients using proton pump inhibitors (ppis). the primary outcome is the change in serum vitamin b12 levels over a 6-week treatment period. secondary outcomes include changes in homocysteine levels, hemoglobin levels, and patient-reported satisfaction.


Eligibility criteria:
inclusion criteria: * age 18-70. * ppi use for 1-6 months (new users). * serum b12 between 150-300 pg/ml. * no known prior b12 supplementation. exclusion criteria: * history of long-term gi disease (e.g., crohn's, celiac). * previous gastrectomy/bariatric surgery. * baseline anemia with hemoglobin \<9 g/dl. * severe renal or liver failure.