Kornimate/medical-research-clean huggingface dataset:
are neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune inflammation score values indicators for postoperative pain?

Conditions: Postoperative Pain Status of Patients Who Underwent Elective Laparoscopic Cholecystectomy

Summary: postoperative pain status of patients who underwent elective laparoscopic cholecystectomy.

subject researched: postoperative pain is a result of the inflammatory response to surgical trauma. local inflammatory mediator response triggered by surgical incision, dissection, retraction, etc. causes an increase in nociceptor sensitivity and hyperalgesia, resulting in the perception of postoperative pain. with the acute phase response caused by surgical trauma, tissue damage is brought under control, infection is limited and the healing process begins. during the inflammatory response, the level of leukocytes in the blood also changes. neutrophil/lymphocyte ratio (nlr), platelet/lymphocyte ratio (plr) and systemic immune inflammation score (sii) are inexpensive and easily accessible biomarkers calculated from routine hemogram parameters and shown to be helpful in disease investigations and evaluation of treatment response. in this study, the relationship between biomarkers and postoperative pain status due to surgery will be investigated

Eligibility criteria:
inclusion criteria: 1. patients aged 18-75 years who underwent elective laparoscopic cholecystectomy. 2. patients with asa status1-2-3 exclusion criteria: 1. emergency operated patients 2. patients switched to open surgery 3. patients allergic to tramadol 4. those allergic to paracetamol 5. those allergic to tenoxicam 6. patients who cannot use the patient-controlled analgesia device 7. those with hematological disorders 8. those receiving immunosuppressive therapy 9. those with inflammatory disease 10. those with gastrointestinal tumors 11. those with rheumatic disease 12. those with uncontrolled diabetes 13. those with chronic organ failure 14. those who use corticosteroids 15. opioid users 16. those who have recently had an attack of cholecystitis, pancreatitis

Keywords: laparoscopic cholecystectomy posoperative pain neutrophil lymphocyte ratio platelet lymphocyte ratio systemic immune inflammation score tramadol consumption
a new approach to target the substrates of persistent atrial fibrillation: the sequential substrate ablation approach

Conditions: Persistent Atrial Fibrillation

Summary: this is a prospective randomized controlled trial that compares the conventional stepwise approach with a new sequential substrate ablation approach for persistent atrial fibrillation.

a total number of 100 patients with persistent af were randomized to receive either conventional stepwise ablation (conventional group) or a sequential substrate ablation (substrate group), both with the endpoint of af termination. all patients were in af before the procedure. the sequential substrate ablation consisted of pulmonary vein isolation (pvi) followed by cardioversion and linear ablation at the mitral isthmus, left atrial roof and cavotricuspid isthmus in order to modify the af substrate. after achievement of bidirectional block, af was re-induced and electrogram-based ablation was performed to achieve af termination to sinus rhythm (sr). endpoints are single-procedure outcome and total amount of rf ablation time required to terminate af by electrogram-guided ablation.

Eligibility criteria:
inclusion criteria: * persistent atrial fibrillation lasting longer than 3 months * no previous ablations * at least 1 electrical cardioversion exclusion criteria: * non-persistent atrial fibrillation * previous ablation procedures

Keywords: persistent atrial fibrillation, catheter ablation, outcome
outpatient recovery from acute kidney injury requiring dialysis

Conditions: Acute Kidney Injury; Dialysis Hypotension

Summary: there are currently no therapies to improve the chances of recovering enough kidney function to come off of dialysis after severe acute kidney injury. it is not known if current routine outpatient dialysis treatments are optimized to maximize the chances of recovery. the purpose of this pilot study is to see if we can feasibly and safely provide several changes to the way that dialysis is provided in outpatient dialysis centers which may improve the chances of recovery.


Eligibility criteria:
inclusion criteria: * aki-d (acute kidney injury requiring dialysis), attributed at least in part to acute tubular necrosis by clinical nephrology team * age ≥ 18 years * pre-hospitalization egfr ≥ 15 ml/min/1.73m2 * being discharged to a participating outpatient dialysis unit (within 30 miles of ucsf) exclusion criteria: * known loop diuretic allergy/intolerance * dialysis duration \> 3 months * pregnant * prisoner * unable to consent * clinical team declines to allow approach for study

Keywords: dialysis-requiring acute kidney injury renal recovery
diagnostic accuracy of wearable technology single-lead ecg in detecting cardiac arrhythmias

Conditions: Cardiac Arrhythmia; Atrial Fibrillation

Summary: atrial fibrillation (af) is the most common arrhythmia (irregular heart rhythm), affecting 1-2 million people in the uk. af significantly increases the risk of an af-related stroke, heart failure and dementia. a significant proportion of people will have no symptoms, and they may only be found to have af after suffering an af-related stroke. an electrocardiogram (ecg) uses sensors placed on the skin to record the heart's electrical activity. a 12-lead ecg uses 10 sensors and is the gold-standard (best available test) to detect any abnormal heart rhythm disturbances. until recently, a 12-lead ecg showing an irregular heart rhythm was required to make a diagnosis of af but as af episodes are often short and unpredictable it may be missed. therefore, a small device that continuously records heartbeat and heart rhythm could make the diagnosis of arrhythmias and af much quicker and easier. accessories such as watches or rings - referred to as wearable devices - have extremely good sensors that measure pulse rate by detecting small changes in skin colour during each heartbeat and can perform a single-lead ecg. algorithms built in the wearable devices can identify irregular heart rhythms, such as atrial fibrillation. the purpose of this study is to test two new wearable devices - the skylabs cart-i ring and the apple watch - in detecting abnormal heart rhythm recording and recording ecgs. the investigators plan to recruit 500 patients attending cardiology departments in several hospitals in the uk and will ask them to wear the apple watch and the cart-i and perform 12-lead ecg with each device (two in total). no extra follow-up visits are required. at the end of the study, the investigators will compare interpretation by two cardiologists of the wearable devices' ecgs and the 12-lead ecgs and look at their ability to automatically detect abnormal rhythms.


Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the trial. * male or female aged 18 years or above. * indication for 12-lead ecg. exclusion criteria: * unable to comply with instructions. * tattoos in the wrists or fingers where the device will be placed. * severe skin allergy to silicone (apple watch wrist band) or nickel allergies.

Keywords: apple watch; skylabs cart-i ring wearable devices
effects of qigong, tai chi and yoga practice in older adults

Conditions: Healthy

Summary: the purpose of this study is to compare the effects of an 8-week intervention using yiren qigong, tai chi or hatha yoga in older adults (age 70 and above) residing at a gencare senior living facility. outcome measures completed at the beginning and end of each intervention period will be blood pressure, heart rate, perceived quality of life (pqol)and a symptoms questionnaire (sf-36), ability and speed of walking 20 feet (for ambulatory participants), and neck and arm range of motion.


Eligibility criteria:
inclusion criteria: * be a resident of a gencare senior living facility in granite falls, lynnwood, renton, ballard and lake city, wa * be at least 70 years of age * be willing to participate in the tai chi, qi gong and/or yoga classes * willing to complete study-related outcomes assessments exclusion criteria: * not medically able to participate in the mild level of activity involved in the 3 interventions as determined by the resident's physician * unable to complete study questionnaires or study procedures at screening

Keywords: geriatric qi gong yoga tai chi geriatric assessment
real-world effectiveness of asciminib and treatment patterns in patients with chronic myeloid leukemia with t315i mutation - a chart review study of patients treated in the asciminib managed access program (map)

Conditions: Chronic Myeloid Leukemia With T315I Mutation

Summary: this non-interventional study (nis) was a retrospective chart review analyzing existing data from patients participating in the asciminib map.


Eligibility criteria:
study population: key inclusion/exclusion criteria inclusion criteria * diagnosis of cml (chronic phase, accelerated phase or blast crisis). * confirmed presence of t315i mutation prior to asciminib initiation. * patients enrolled in the asciminib map and received their first dose of asciminib between 01 november 2018 and 30 april 2022. patients must have received at least one dose of asciminib. * appropriate approval was obtained for the patient chart review including: * patient signed the informed consent form (icf) or, * individual icf waiver was granted by an institutional review board/ independent ethics committee (irb)/ iec. exclusion criteria • age less than 18 years old at the time of initiating asciminib treatment.
a behavioral intervention to decrease vomiting and improve weight loss in post-operative laparoscopic adjustable gastric banding (lagb) patients

Conditions: Bariatric Surgery Complications

Summary: the purpose of this study is to reduce problematic vomiting and associated gastrointestinal symptoms in post-operative lagb patients. we hypothesize that our behavioral intervention will yield greater reductions in vomiting and associated symptoms compared to our control condition.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 70 years. 2. received lagb surgery with either a standard lap-band or a standard realize band. 3. report vomiting at least 3x/week. 4. agree to allow researchers to communicate with their surgeon regarding their care. 5. fulfilled all hospital surgery criteria. exclusion criteria: 1. report a condition that in the judgment of the principal investigator would render them potentially unlikely to follow the protocol (e.g., major illness, plans to move out of the area, substance abuse or other significant psychiatric problems, organic brain disease). 2. report planning to become pregnant during the time frame of the investigation. 3. report a history of upper gastrointestinal dismotility.
survey stroke units in argentina

Conditions: Surveys and Questionnaires; Evaluation of Processes and Results; Healthcare; Evidence-based Clinical Practice; Health Care System; Stroke; Patient Discharge

Summary: introduction patients who receive care from stroke units are more likely to survive their stroke, become independent, and return home. decision-making to decide the location of discharge is influenced more by non-clinical factors than clinical ones. objective to analyze the factors that are considered for discharge and how stroke patients are measured in stroke units in argentina by the physicians who make the decisions. materials and methods an observational, analytical, cross-sectional survey-type study will be carried out. the recommendations given by the checklist for reporting of survey studies will be used. it will be intended for all those physicians in argentina who work in stroke units and discharge.


Eligibility criteria:
inclusion criteria: * all physicians who in stroke units of argentina and are in charge of the referral process for hospitalized patients will be included. exclusion criteria: * all surveys with missing data will be excluded
near infrared technology and laparoscopic resection of pancreatic lesions: the colpan project

Conditions: Pancreatic Neuroendocrine Tumors; Clear Cell Renal Carcinoma; Solid Pseudopapillary Tumors of the Pancreas

Summary: the purpose of this study is to determine whether the use of near-infrared technology can guide the laparoscopic resection of hypervascular neoplasms of the pancreas.


Eligibility criteria:
inclusion criteria: * age between 18 and 80 * diagnosis of hypervascular pancreatic neoplasms to be treated with laparoscopic surgery exclusion criteria: * allergy to indocyanine green or other vital stains, indium, shellfish * chronic kidney insufficiency * chronic hepatopathy * hyperthyroidism, thyroid adenomas
time restricted feeding on impaired glucose regulation(trig trial)

Conditions: Time-Restricted Feeding; Impaired Glucose Regulation; Overweight/Obese

Summary: we evaluated the effects of time-restricted feeding (trf) regimen on impaired glucose regulation (igr) in comparison with overweight/obese patients receiving standard of care over 12 months.


Eligibility criteria:
inclusion criteria: 1. aged ≥ 18 year 2. diagnosis of impaired glucose regulation (i.e. fg between 5.7-6.9mmol/l) +/- impaired glucose tolerance (i.e. 2-hour postprandial pg between 7.8-11.1mmol/l) confirmed by latest ogtt results within 3 months prior to recruitment 3. body mass index (bmi)of 23.0 to 45.0 kg/m2; exclusion criteria: 1. confirmed diagnosis of dm or on hypoglycaemic treatment 2. women who are pregnant or breast-feeding at recruitment 3. patients taking glucocorticoid at recruitment 4. active and uncontrolled thyroid diseases (including subjects on thyroid replacement therapy or anti-thyroid drugs) or active endocrine diseases such as cushing's syndrome or acromegaly at recruitment 5. serious liver dysfunction or chronic kidney disease (ast or alt \> 3 times the upper limit of normal, or egfr\<30 ml/min/1.73 m2); 6. history of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 6 months; 7. taking medications affecting weight or energy intake/energy expenditure in the last 6 months, including weight loss medications, antipsychotic drugs or other medications as determined by the study physician; 8. currently participating in weight loss programs or weight change in the past 3 months (\> 5% current body weight) ; 9. patients who cannot be followed for 24 months (due to a health situation or migration); 10. patients who are unwilling or unable to give informed consent.
effects on liver cirrhotic patients' by a nurse-led clinic

Conditions: Liver Cirrhosis

Summary: this study compare the effects of traditional follow-up by physician with a combined follow-up alternately by physician and nurse-led clinic. the main variable is; health related quality of life. participants are randomized into control group or intervention group.

the incidence of liver cirrhosis in sweden increase mostly due to life style factors. a large need of care is common in the end stage of the disease. nurse-led clinics for other groups of patients, e.g. coronary heart disease, have shown high quality which has resulted in an established part of the follow-up. this study is a randomized controlled study at six swedish hospitals to study the effect of a changed follow-up process for liver cirrhotic patients by adding a nurse-led clinic to follow up by physician. the intervention implies a larger extend of nursing interventions at the outpatient clinic to increase the patient's quality of life, quality of care and reduce the need of inpatient care. a few hospitals in sweden offers a nurse-led clinic for liver cirrhotic patients, the interest in other hospitals are raising. though there is a lack of evidence in nursing intervention within this population and it is still unknown what the effects are for the individual or on the health economy.

Eligibility criteria:
inclusion criteria: * within the last 24 months diagnosed liver cirrhosis based on clinical investigation, laboratory findings, histology, magnetic resonance imaging, computer tomography, ultrasound or elastography * followed at one of the six gastroenterology departments exclusion criteria: * insufficient knowledge of the swedish language * persistent hepatic ecephalopathy grades 2-4 * comorbidity: chronic obstructive pulmonary disease grade 3-4, coronary heart disease new york heart association functional classification class 3-4, dementia, actual advanced cancer, stroke with sequelae, severe psychiatric disease, renal failure requiring dialysis

Keywords: quality of care health related quality of life nurse-led clinic health economics
predictors of postoperative delirium in elder patients after spine surgery: regional cerebral oxygen saturation

Conditions: Postoperative Delirium in Elder Patients After Spine Surgery

Summary: postoperative delirium is an important problem in patients undergoing major surgery. the incidence of delirium was 12.5% in the patients over 70 years old undergoing spine surgery. a study shows that a low preoperative regional cerebral oxygen saturation (rso2) is associated with postoperative delirium after on-pump cardiac surgery. this same perturbation likely also increases the risk for postoperative delirium after spine surgery, although there are little data that have evaluated this hypothesis. therefore, this observational study was designed to explore the relationship between perioperative rso2 and the delirium in elderly patients undergoing spine surgery.


Eligibility criteria:
inclusion criteria: 1. patients in the study will be 60 or older undergoing elective major spine surgery (expected operative time is more than 2 hrs). 2. patients who can do the mini-mental state examination (mmse), confusion assessment method for the icu (cam-icu) and intensive care delirium screening checklist (icdsc). 3. patients who understand the nature of the study and are willing to sign the consent form exclusion criteria: 1. emergency surgery 2. patients diagnosed with neurocognitive disorders or psychiatric diseases, thus, cannot check mmse or communicate with other people (e.g. alzheimer's dementia, alcohol abuse) 3. patients diagnosed with cerebrovascular disorders (e.g. stroke, atherosclerotic stenosis of carotid artery, tia) 4. patients who cannot be followed up until 2 days after surgery

Keywords: spine surgery cerebral oximetry postoperative delirium
ubiquitous spaced retrieval-based memory advancement and rehabilitation training

Conditions: Mild Cognitive Impairment

Summary: the purpose of this study is to examine feasibility and efficacy of the ubiquitous spaced retrieval-based memory advancement and rehabilitation training (u-smart) in the elderly individuals with mild cognitive impairment (mci).

the spaced retrieval-based memory advancement and rehabilitation training (smart) which consisted of 24 one-hour face-to-face sessions (lee, park et al. 2009) was developed based on the spaced retrieval training (srt), which was effective in improving memory retention span of very mild to mild alzheimer's disease patients. the ubiquitous smart (u-smart) by transforming the current smart to a self-administered program using an application working on ipad was developed, and was examined its feasibility and efficacy in the elderly individuals with mild cognitive impairment.

Eligibility criteria:
inclusion criteria: * aged 55-90 * educational level above 1 year and confirmed literacy * diagnosed to mild cognitive impairment by international working group on mild cognitive impairment * clinical dementia rating (cdr) of 0 or 0.5 exclusion criteria: * diagnosed to dementia by dsm-iv * evidence of delirium, confusion * any neurological conditions causing cognitive decline such as parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus * evidence of severe cerebrovascular pathology * history of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity * history of substance abuse or dependence such as alcohol * presence of depressive symptoms that could influence cognitive function * presence of medical comorbidities that could result in cognitive decline * use of medication that could influence cognitive function seriously

Keywords: mild cognitive impairment cognitive rehabilitation cognitive therapy spaced retrieval training alzheimer's disease memory enhancement u-healthcare
prospective pilot trial to address feasibility and safety of oral zinc in gnao1 associated disorders

Conditions: GNAO1; Dystonia; Epilepsy; Development Delay; Developmental and Epileptic Encephalopathy 17; Neurodevelopmental Disorder With Involuntary Movements; Choreoathetosis

Summary: the goal of this clinical trial is to investigate feasibility and safety of an oral therapy with zinc in patients affected by guanine nucleotide-binding protein g(o) subunit alpha (gnao1) associated disorders. the main questions it aims to answer are: * is a daily oral therapy with zinc in gnao1 associated disorders a safe and feasible therapy? * are there potential changes in general motor skills, general behaviour and well being, day/night rhythm, level of dyskinesia and dystonia, frequency of seizures, quality of life and changes in the microbiome of the patients. participants with gnao1 associated disorders will be given an oral zinc therapy for 6 month and will be assessed in 3 visits and 2 phone calls within this trial.


Eligibility criteria:
inclusion criteria: * gnao1 associated neurological disorder, documented by either * proven pathogenic or likely pathogenic mutation in gnao1 or * a variant of unknown significance in gnao1 and clinical symptoms likely to be consistent with gnao1 as determined by the investigators and * at least one of the common symptoms of gnao1: movement disorder (dystonia, chorea, ataxia, clonic), central muscular hypotonia, epilepsy, global developmental delay * age: 6 month - 30 years * gmfm ≤ 75 * written informed consent prior to any trial-related procedure (according to age and status of psycho-intellectual development) * of parents or legal guardian * of parents or legal guardian and patient * of the patient * stable on following concomitant treatments for at least 3 months prior to trial inclusion: anti-seizure drugs (asd); baclofen, deep brain stimulation settings exclusion criteria: * treatment of zinc in the last 4 months before inclusion * known other genetic variants that are known to cause symptoms like observed in gnao1-related disorders, additional to the proven gnao1 mutation * implantation of deep brain stimulation planned during the duration of the trial, i.e. in the six months after inclusion * start of intrathecal baclofen therapy planned during the duration of the trial, i.e. in the six months after inclusion * known allergy/hypersensitivity to the scheduled trial drug * concomitant participation in other clinical drugs with investigational drugs or with competing interventions * sexually active patients who are not willing to use/ not using a highly effective contraception method with a pearl-index \< 1. sexually active patients, unless surgically sterile, must be using a highly effective contraception method (including oral, transdermal, injectable or implanted contraceptives, intrauterine device (iud), using a condom of the sexual partner or sterile sexual partner) and must agree to continue using such precautions during the whole study period. * pregnant women and nursing mothers

Keywords: gnao1