Kornimate/medical-research-clean huggingface dataset:
tes modalities for the treatment of adhd

Conditions: Attention Deficit Disorder With Hyperactivity; Neurodevelopmental Disorders

Summary: this project investigates the efficacy of transcranial electrical stimulation (tes) modalities, specifically transcranial direct current stimulation (tdcs) and transcranial alternating current stimulation (tacs), for treating attention-deficit/hyperactivity disorder (adhd) in children and adolescents.

this project aims to evaluate the therapeutic potential of transcranial electrical stimulation (tes) modalities, specifically transcranial direct current stimulation (tdcs) and transcranial alternating current stimulation (tacs), as innovative, non-invasive interventions for managing attention-deficit/hyperactivity disorder (adhd) in children and adolescents. adhd is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity that impair daily functioning. conventional treatments, such as pharmacological interventions and behavioral therapies, may have limitations, including side effects or variable efficacy, prompting the exploration of neuromodulation techniques like tes.

Eligibility criteria:
inclusion criteria: * diagnosis of adhd by a licensed psychiatrist and a behavioral checklist * being 7-18 years old * providing written informed consent signed by parents exclusion criteria: * comorbidity with other neurodevelopmental disorders * comorbidity with other neurological disorders * previous history of neurosurgery * presence of any ferromagnetic metal in the head * implanted medical devices in the head or neck region * history of non-controlled epilepsy with seizures in the last year
long term follow up of small non-inflammatory pancreatic cysts

Conditions: Pancreatic Cysts

Summary: this study intends to investigate the long term follow-up of small non-inflammatory pancreatic cysts.

this study intends to investigate the long term follow-up of small non-inflammatory pancreatic cysts in a multicenter setting. inclusion criteria: patients with non-inflammatory pancreatic cystic lesions up to 3 cm in diameter referred to the university hospital hamburg eppendorf, israelitic hospital hamburg, sana klinikum lichtenberg, berlin and krankenhaus märkisch-oderland,strausberg from 2002 to 2007 identified from eus database. study design: at least 5 year-long term follow up by inclusion of clinical data, cross sectional imaging if available or actual us findings. primary outcome: to determine the proportion of patients with increase is size and/or changed appearance secondary outcomes: rate of patients undergo pancreatic surgery (indication, histology of resected specimen). rate of patients undergo fna (fluid analysis, cytology).

Eligibility criteria:
inclusion criteria: * patients with non-inflammatory pancreatic cystic lesions up to 3 cm in diameter exclusion criteria: * acute or chronic pancreatitis * pancreatic cysts \> 3 cm * lesion suspicious for malignancy

Keywords: incidental pancreatic cysts
the role of vitamin d in immune function in patients with chronic kidney disease (ckd) stages 3 and 4.

Conditions: Chronic Kidney Disease

Summary: patients with chronic kidney disease (ckd) are commonly deficient in vitamin d, with low levels of both calcidiol (25 hydroxy vitamin d) and calcitriol (1,25-hydroxy vitamin d). patients with ckd are also known to have abnormalities in their immune cells, increased susceptibility to infection and increased prevalence of malignancies. in patients without kidney disease, repletion of vitamin d appears to help some immune mediated diseases. thus it is logical that patients with ckd who are vitamin d deficient may benefit from repletion of vitamin d, in either its native form (cholecalciferol/ergocalciferol) or in the form of calcitriol or its analogues. however, no interventional data demonstrates that repletion positively impacts immune status in ckd patients. to test this hypothesis, a large interventional study will be required. however, prior to conducting this study, several important steps are needed. the present proposal aims to generate the necessary data to appropriately plan and conduct a future multi center interventional study. specifically, we will examine the following specific aims in a population of ckd stage 3 and 4 subjects from indiana university affiliated nephrology clinics and determine 1. if abnormalities in immune cells and immune blood tests are related to abnormalities in vitamin d. 2. how reproducible these changes are on repeat testing and 3. if repletion of vitamin d changes these cells and immune blood tests in a small pilot study.


Eligibility criteria:
inclusion criteria: * no administration of any form of vitamin d supplement or therapy in the last 60 days except for that in a multi vitamin * hgb \>10 mg/dl * able to sign informed consent * ckd stage 3 (gfr 30-59ml/min) or stage 4 (gfr 15-29ml/min) * ipth \<70pg/ml for stage 3 or ipth \<110pg/ml for stage 4 * calcidiol levels \< or +20ng/ml exclusion criteria: * initial corrected calcium \>9.7mg/dl * initial serum phosphorus \>5.0mg/dl * initial standardized blood pressure of \>160/100 * history of significant liver disease or cirrhosis * anticipated requirement for dialysis in 6 months * malabsorption, severe chronic diarrhea, or ileostomy * no calcimimetic or active vitamin d therapy 60 days prior to enrollment

Keywords: vitamin d determine normal intrapatient interpatient variability measures immune system
study of fenretinide in the treatment of geographic atrophy associated with dry age-related macular degeneration

Conditions: Geographic Atrophy; Dry Age Related Macular Degeneration

Summary: the purpose of this phase ii study is to determine the efficacy of fenretinide in the treatment of geographic atrophy (ga) in subjects with the dry form of age-related macular degeneration (amd).


Eligibility criteria:
inclusion criteria: * males or females, 50 to 89 years of age * must have ga from amd in one or both eyes exclusion criteria: * ga due to any disease other than amd (eg, drug-induced)

Keywords: dry age related macular degeneration geographic atrophy
preventive effect of the pretreatment with intravenous nicorandil on contrast-induced nephropathy in patients with renal dysfunction undeergoing coronary angiography (principle study)

Conditions: Chronic Renal Failure

Summary: renal hypoxia plays an important role in the development of contrast-induced nephropathy. the purpose of the principle study is to investigate the effect of pretreatment with intravenous nicorandil on the incidence of contrast-induced nephropathy in patients with renal insufficiency undergoing coronary angiography.


Eligibility criteria:
inclusion criteria: * patients aged ≥ 20 years * patients undergoing elective coronary angiogram due to documented myocardial ischemia or symptoms of angina * estimated cr clearance ≤60 ml/min by cockcroft-gault formula or serum cr ≥1.1 mg/dl * signed written informed consent to participate in the study exclusion criteria: * acute myocardial infarction requiring primary or rescue coronary intervention * allergic reaction to contrast dye or nicorandil * cardiogenic shock or significant hypotension * previous use of nicorandil within the preceding 7 days * exposure to contrast medium within the preceding 7 days * pregnancy or women at age of childbearing potential * heart failure (nyha class iii or iv; lv ejection fraction \<40% by echocardiogram) * acute renal failure or chronic dialysis * mechanical ventilation * history of kidney transplantation * life expectation less than 6 months * previous renal artery angioplasty within the last 6 months * use of nonsteroidal anti-inflammatory drugs, intravenous use of diuretics, dopamine, mannitol, n-acetylcysteine, ascorbic acid or sodium bicarbonate within 48 hrs before the procedure * severe liver disease

Keywords: patients with chronic renal failure undergoing coronary angiography
effect of lidocaine patch for shoulder pain in laparoscopic cholecystectomy

Conditions: Gallbladder Diseases

Summary: the primary purpose of this study is to investigate the effect of lidocaine patch on the shoulder pain score after end of surgery. the secondary purpose of this study is to investigate the effect of lidocaine patch on the total number of analgesic request on ward.


Eligibility criteria:
inclusion criteria: * laparoscopic cholecystectomy under general anesthesia exclusion criteria: * infection, trauma, or bleeding on shoulder * allergy to lidocaine * chronic pain * renal dysfunction * liver dysfunction * seizure * history of shoulder surgery
a randomized controlled trial to determine outcome and cost effectiveness of case management of chronic obstructive pulmonary disease (copd) patients

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: this randomized controlled trial (rct) will examine a nurse case management model for patients suffering from chronic obstructive pulmonary disease (copd) in a danish municipality, and is performed in order to evaluate the use of case management as a tool in achieving integrated, quality and cost-effective care for this group of patients. the main objectives are to evaluate how case management influences on hospital admissions, mortality, quality of life and self care, as well as to compare costs and cost-effectiveness of case management vs. usual care.

case management is being implemented as a health service strategy that should contribute to maximize health outcomes within a cost-constrained environment. evaluations of case management in danish settings are sparse, and so far no danish studies have evaluated the cost-effectiveness of case management. this study is performed as a rct, and the study focuses exclusively on patients with copd. the patients will be enrolled and randomized after being referred to rehabilitation at the local rehabilitation center in aalborg municipality, denmark. 150 patients will be randomly assigned to two groups of 75 patients each. participants in the control group will receive usual care, whereas patients assigned to the interventional group will receive case management besides their usual care. each patient will be followed for 12 months. patients in both groups will fill out questionnaires at baseline and 12 months. the data register system "health - planning and quality" in the northern region of jutland will be used to determine health care services and costs.

Eligibility criteria:
inclusion criteria: * patients who are clinically referred to rehabilitation at aalborg rehabilitation center for their diagnosed copd exclusion criteria: * patients living outside aalborg municipality, or who is considering to move to another municipality or country in near future. * patients without a telephone * patients with dementia * patients participating in other research studies

Keywords: copd case management cea health economy quality of life
buprenorphine pharmacology related to addiction treatment - 18

Conditions: Opioid-Related Disorders

Summary: the purpose of this study is to examine the interactions between buprenorphine and naltrexone, and to assess how they may directly impact the clinical issues involving: transferring patients from buprenorphine to naltrexone, developing a non-abusable form of buprenorphine, and enhancing patient acceptability of naltrexone.


Eligibility criteria:
please contact site for information.
macula evolution in patients with amd taking oral food supplementation

Conditions: Age Related Macular Degeneration

Summary: lt7082-001 is an open-label, single-arm pilot study. patients with intermediate age-related macular degeneration (amd) wil take t7082 during 12 months , an association of 4 food supplementations . the study objectives are to describe morphological changes and evolution of drusen in macula after a 12-month of food supplementation and to assess the safety of t7082


Eligibility criteria:
inclusion criteria: * informed consent signed and dated * age ≥ 50 years old * at least one eligible eye, defined by following conditions : 1. far best corrected visual acuity (bcva) ≥ 75 etdrs letters (or ≥ 20/32 snellen equivalent) 2. at least one drusen with a minimal diameter of 125 µm assessed by sd-oct / intermediate age-related macular degeneration 3. macula sparing 4. clear ocular media 5. adequate pupillary dilation exclusion criteria: * presence of other macular disease such as epiretinal membrane or macular telangiectasia. * presence of any geographic atrophy including macular region * any history of retina neovascularization * macula or retinal diseases other than age-related macular degeneration * a concurrent ocular pathology that may contribute to vision loss (eg, choroidal neovascularization, glaucoma, visually significant cataract, optic neuropathy, history of retinal surgery) or interfere with acquisition of high-quality images * ocular or periocular infections * presence of congenital retinal pathologies that may impact data collection * exudative amd
dbt for metastatic lung cancer

Conditions: Lung Cancer Metastatic

Summary: metastatic lung cancer patients experience significantly greater psychological distress (i.e., depression, anxiety) compared to other cancers. psychological distress is as a prognostic indicator for worse clinical outcomes and poorer overall survival in cancer patients. dialectical behavioral therapy (dbt) is a trans-diagnostic, evidence-based psychotherapy that teaches participants a core set of behavioral skills (distress tolerance, emotion regulation, mindfulness, interpersonal effectiveness) to cope more effectively with emotional and physical symptoms. the proposed study seeks to adapt and pilot test dbt skills training for patients with metastatic lung cancer using the adapt-itt framework. participants will be metastatic lung cancer patients who score \>=3 on the national comprehensive cancer network distress thermometer. phase i aims to use focus groups and interviews with key stakeholders (metastatic lung cancer patients (n=20), thoracic oncology providers (n=6), clinicians with expertise in survivorship and behavioral symptom management (n=6)) to determine if and how dbt skills training must be modified for implementation with metastatic lung cancer patients. adapted material will be reviewed by topical experts in dbt and implementation science to produce a manualized, adapted dbt skills training protocol for metastatic lung cancer patients (livewell). phase ii aims to pilot test livewell (n=30) to assess feasibility, acceptability, and examine pre-to-post intervention outcomes of psychological distress, (i.e., depression and anxiety) fatigue, dyspnea, pain, emotion regulation, tolerance of uncertainty, and dbt coping skill use. livewell will consist of coping skills training sessions delivered either in-person or via videoconferencing technology. study measures will be collected at baseline, immediately post-intervention, and 1-month post-intervention.


Eligibility criteria:
inclusion criteria: 1. be diagnosed with metastatic (ajcc stage iv) non-small cell lung cancer 2. be undergoing systemic treatment (chemotherapy, targeted therapy, and/or immunotherapy) for lung cancer at duke cancer institute 3. score \>3 on the national comprehensive cancer network distress thermometer for distress over the past week (range: 0-10) 4. be \> 18 years of age 5. be able to understand, speak, and read english 6. be able to provide informed consent exclusion criteria: 1. reported or suspected cognitive impairment subsequently informed by a montreal cognitive assessment (moca) of \<26 2. presence of untreated serious mental illness (e.g., schizophrenia) indicated by the medical chart, treating oncologist, or other medical provider 3. expected survival of 4 months or less

Keywords: dialectical behavioral therapy skills training lung cancer
telerehabilitation and conventional physiotherapy program for caregivers of individuals with special needs

Conditions: Telerehabilitation; Neck Pain

Summary: the study was planned to investigate the effectiveness of home therapy method due to the difficulties experienced by caregivers of individuals with special needs in accessing physiotherapy and rehabilitation services for chronic neck and back pain.

caring for a disabled child is a very difficult and long process for parents. in this process, mothers and fathers exert a lot of effort while caring for the child, carrying the child and playing an active role in its rehabilitation. for these reasons, it is reported that the physical health of mothers and fathers is negatively affected and they often experience waist and back pain. telerehabilitation allows patients who cannot access rehabilitation due to geographical, economic or physical disabilities to benefit from rehabilitation services. the distance problem is especially valid in cases where people live far from the rehabilitation center, there are no rehabilitation professionals specialized in the relevant disease in the place of residence, when transfers are difficult due to mobility problems, and in cases where it is not possible or risky to go to the rehabilitation center due to epidemics, as is the case today. telerehabilitation has the potential to overcome all these problems. the study was planned to investigate the effectiveness of home therapy method due to the difficulties experienced by caregivers of individuals with special needs in accessing physiotherapy and rehabilitation services for chronic neck and back pain.

Eligibility criteria:
inclusion criteria: * being between 20-60 years old, * being a special needs child caregiver, * mechanical neck and back pain lasting 3 months or longer exclusion criteria: * those who are caregivers of hearing and visually impaired children, * having previously undergone surgery in the cervical region, * patients with a history of inflammatory or infective arthritis in the cervical spine, * congenital spinal cord anomaly, * history of malignancy, * having neuropathic pain * radiculopathy, myelopathy or other neurological disorders * those with chronic lung disease * vestibular disorders, * those with a history of continuous drug use, * individuals who have been involved in an exercise or physiotherapy program in the last 3 months, * he will not be able to read the scales and the evaluation parameters will be excluded from the study.

Keywords: individual with special needs back pain
re-compensation and its clinical characteristics in hbv decompensated cirrhosis

Conditions: Hepatitis B; Decompensated Cirrhosis

Summary: in this study, treatment-naïve hbv-related cirrhosis patients were retrospectively enrolled at the first episode of decompensation (ascites or variceal hemorrhage). patients were followed up every 6 months until death /liver transplantation or for 5 years. clinical data from medical records about past history, first decompensated events, second /further decompensated events, hcc, and death/ liver transplantation were retrospectively collected. in this retrospective study, the incidence of re-compensation and its clinical characteristics were mainly explored.

in this study, treatment-naïve hbv-related cirrhosis patients were retrospectively enrolled at the first episode of decompensation (ascites or variceal hemorrhage). patients were followed up every 6 months until death /liver transplantation or for 5 years. wbc, rbc, hgb, plt, crp, pt, pta, inr, alt, ast, tb, db, alb, glo, alp, ggt, che, bun, cr, na, glu, chol, tg, hdl-c, ldl-c, afp, hbsag, hbv-dna, lsm, bus, mri/ct and gastroscope from medical records about past history, first decompensated events, second /further decompensated events, hcc, and death/ liver transplantation were retrospectively collected. this retrospective study aimed to explore the incidence of re-compensation and its clinical characteristics.

Eligibility criteria:
inclusion criteria: 1. ascites and/or variceal hemorrhage (vh) as the first decompensated events; 2. initiating antiviral therapy within 3 months of the first decompensated events; 3. clinical parameters were available at the first decompensated events, including plt, alt, alb, tb, pt/inr, cr, hbv dna, bus, 4. clinical outcomes were classified: 1. without further decompensation: medical records at year-1, year 2 to 4, and year-5 were available. 2. with ≥ 2 episodes of decompensation: medical records for decompensation were available. exclusion criteria: 1. hepatocellular carcinoma prior to /within 6 months of first decompensated events; 2. liver transplantation /death within 6 months of first decompensated events; 3. complicated with other chronic liver diseases, including hcv, dili, aih, nafld, ald. 4. any complication of severe heart, lung, kidney, brain, blood diseases or other severe systematic diseases; 5. pregnant women.

Keywords: re-compensation treatment-naive hbv decompensation
influence of microcurrent parameters on effectiveness in treatment of chronic tennis elbow

Conditions: Tennis Elbow

Summary: tennis elbow is a relatively common musculoskeletal disorder that can cause significant pain and disability. treatment of the disorder is not always successful, and it often recurs or becomes chronic. more effective management options are required. there is evidence that electric microcurrent can promote tissue healing and symptom resolution in various chronic hard and soft tissue disorders, but few human studies have investigated its use with chronic tendon problems. it is an easily applied therapy with very few reports of side effects. it can be applied at home using a portable unit and, if it is clinically effective, may also prove more cost effective than other therapies. a clinical trial is planned to evaluate the therapy but, in the absence of relevant published evidence, a preliminary study is required to look for a treatment effect and inform a power calculation for sample size, the study is comparing the effects of two different forms of microcurrent treatment.


Eligibility criteria:
inclusion criteria: * symptoms of tennis elbow for at least 3 months * clinical diagnosis of tennis elbow exclusion criteria: * significant symptom improvement in previous month * receipt of any active treatment for the condition in the previous month * currently under the care of another health professional for tennis elbow * current cervical radiculopathy

Keywords: tendon healing microcurrent chronic tennis elbow
a study to evaluate the efficacy and safety of co-administration of ad-2281 and ad-2282

Conditions: Primary Hypercholesterolemia

Summary: the purpose of this study is to evaluate the efficacy and safetyof co-administration of ad-2281 and ad-2282 in patients with primary hypercholesterolemia


Eligibility criteria:
inclusion criteria: * signed informed consent * patients with primary hypercholesterolemia * other inclusions applied exclusion criteria: * patients with secondary hypercholesterolemia * other exclusions applied