Kornimate/medical-research-clean huggingface dataset:
expression of optic atrophy type 1 (opa1) protein in lung adenocarcinoma

Conditions: Lung Adenocarcinoma

Summary: optic atrophy type 1(opa1) is a nuclear dynamin-related gtpase, targeted to the inner mitochondrial membrane, which plays a role in mitochondrial fusion. mitochondria fusion is associated with process of apoptosis. . opa1 plays an important role in the mitochondrial bioenergetics and mitochondrial networks. the changes in mitochondrial shape and mitochondrial bioenergetics may be cause of the disease. in this study, we investigate the expression of opa1 in lung adenocarcinoma (ladc) cells and tissue.


Eligibility criteria:
inclusion criteria: * we will collect paraffin blocked resected lung tissue samples from stage i\~iiia non-small cell lung cancer patients (age, 40\~80 years old) who received lobectomy of the affected lung. exclusion criteria: * history of uremia, other malignant disease, and liver cirrhosis * history of pneumonia and pulmonary tuberculosis * history of long period of medications.

Keywords: opa1 lung adenocarcinomas prognosis expression of optic atrophy type 1 (opa1) protein in lung adenocarcinoma
physical activity program and nutrition therapeutic education during treatment of head and neck cancer population

Conditions: Neck Cancer

Summary: the purpose of this study is to examine the feasibility of resistance training and physical functioning associated with nutrition therapeutic education in head and neck cancer patients, during their treatment (chemotherapy with or without radiotherapy).

the loss of muscle mass (i.e., sarcopenia) has been identified as a negative prognosis descriptor, disregarding the type of cancer. it is also a predictive descriptor for treatment-related toxicity. therefore it appears crucial to save muscle mass of patients, following an adequate physical training together with a personalised diet program. the latter point is of major importance as malnutrition concerns 45% patients having head and neck cancer cancer, who stop physical activity due to extreme tiredness and decrease of quality of life. in the present project, we plan a physical activity program that would be adapted to each patient, accompanied by the rethought diet over a 3-month period. the adapted physical activity (apa) is constituted of two aerobic stages and one resistance training stage per a week. the evaluation will then proceed at three different moments, namely (i) at t0 i.e., beginning of the program, (ii) at 3 months i.e., when the program will be stopped, and (iii) at 6 months i.e., three months after the program stop. this evaluation will include the success rate, the level of satisfaction, the physiological parameters (vo2max, muscle mass and strength, bmi) and quality of life.

Eligibility criteria:
inclusion criteria: * age\>18 years * written informed consent provided before any study specific procedures * consent to cooperate for clinical assessments * affiliation to a social security regime or beneficiary of equivalent social protection * performance status between 0 and 2 * squamous cell carcinoma of oral cavity, oropharynx or hypopharynx * stage iii - iv (t1-t4, n0-n3, m)(uicc 2002) * indication of radiotherapy and chemotherapy post-operative or first-line metastatic chemotherapy or in inoperable condition * ability to understand the nature, goal and study methodology exclusion criteria: * prior neoadjuvant chemotherapy * timed vital capacity\< 70% * presence of another severe pathology including: * severe or chronic cardiac, pulmonary, renal and/or hepatic insufficiencies * cons-indication to physical activity practice, at discretion of the investigator * patient under guardianship * psychological, social, geographical, or familial reasons prohibiting physical activity and follow-up * any other primary tumor during the last 5 years * pregnant or nursing

Keywords: head and neck cancer, physical activity, nutrition therapeutic education
effect of biliopancreatic diversion on glucose homeostasis

Conditions: Obesity, Morbid

Summary: biliopancreatic diversion (bpd) surgery results in greater resolution of type 2 diabetes than all other bariatric surgical procedures, and it is hypothesized that this procedure has specific beneficial effects on glucose homeostasis beyond weight loss alone. the bpd procedure is performed in more than 150 patients/year by surgeons at the division of obesity and metabolic disorders, catholic university of the sacred heart, school of medicine, in rome, italy. the purpose of this study is to provide a better understanding of the effect of the bpd bariatric surgical procedure on insulin action and pancreatic beta cell function. it is hypothesized that weight loss achieved with bpd surgery will have greater effects on insulin sensitivity and beta cell function than weight loss induced by roux-en-y gastric bypass (rygb).


Eligibility criteria:
inclusion criteria: * body mass index (bmi) ≥ 35 kg/m² * undergoing either the rygb or the bpd procedure. * able to provide informed consent to participate in the research study exclusion criteria: * weight \> 450 pounds * smoke \> 7 cigarettes per day * previous malabsorptive or restrictive intestinal surgery * pregnant or breastfeeding * inflammatory intestinal disease * diabetes * unstable dose of medications in the last 4 weeks before the pre-surgery metabolic studies * severe organ dysfunction

Keywords: bariatric surgery roux-en-y gastric bypass biliopancreatic diversion
reach-out: chicago children's diabetes prevention program

Conditions: Obesity; Type 2 Diabetes

Summary: the purpose of this research study is to evaluate two nutrition and exercise programs in children ages 9-12 who are at risk for developing type 2 diabetes. this study also includes the involvement of parents or guardians who are willing to participate in these programs with the child.

this is a prevention study that evaluates a community-based, family oriented intervention called reach-out. the university of chicago will partner with community organizations including the women, infants and children \[wic\] clinic at the chicago department of public health roseland clinic, south side ymca, the chicago park district and the southside faith-based wellness network of churches to deliver the intervention. families will be recruited from the high risk population of patients in the university of chicago diabetes database and the chicago childhood diabetes registry; and la rabida children's hospital; and from the broader south side african-american community ("outreach" population). families will be randomized to behavioral intervention (reach-out program, hands on nutrition and exercise) or control group(reach-in program, standard of care consultation). all who participate in this study will be seen at the university of chicago gcrc (general clinical research center). they will be asked to come in at the beginning of the study, after 14 weeks, afer 1 year and after 2 years.

Eligibility criteria:
inclusion criteria: * overweight (\>85th percentile bmi for age and gender) african american child age 9-12 with family history of type 2 diabetes in a first or second degree relative. parents are secondary subjects. exclusion criteria: * inability to give informed consent or unwillingness to be randomized * prior diagnosis of diabetes in the child planning to participate * pregnancy (women who become pregnant during the study will be omitted from the analysis. pregnant women will not participate in the exercise sessions). * uncontrolled hypertension (sbp\> 160 or dbp\>100) (jnc v, 1993) * uncontrolled dyslipidemia by ncep iii criteria (ncep, 2001) * evidence of significant cardiovascular, pulmonary disease, or other serious illness * evidence of alcohol or drug abuse (identified by self-report) * musculoskeletal disease serious enough to prevent participation in exercise sessions * known or suspected major psychiatric disorder * inability to participate in aerobic exercise activities * inability to comply with a calorie or fat restricted diet * age over 65 years

Keywords: obesity type 2 diabetes african american children african american youth community based family oriented obesity & risk of type 2 diabetes
treatment of locally advanced vulvar carcinoma in a neoadjuvant setting with carboplatin and paclitaxel chemotherapy (vulcanize)

Conditions: Locally Advanced, Squamous Cell Carcinoma of the Vulva

Summary: vulvar cancer is a rare malignancy. surgery is the treatment of choice, but frequently causes invalidating and chronic postoperative morbidity, especially in patients with high stage disease. theoretically, downstaging with neoadjuvant chemotherapy could shrink the tumour, making surgical treatment less extensive thereby diminishing the chance for morbidity.

vulvar cancer is a rare malignancy. surgery is the treatment of choice, but frequently causes invalidating and chronic postoperative morbidity, especially in patients with high stage disease. theoretically, downstaging with neoadjuvant chemotherapy could shrink the tumour, making surgical treatment less extensive, thereby diminishing the chance for morbidity.

Eligibility criteria:
inclusion criteria: * woman k 18 years * signed and written informed consent. * histologically confirmed squamous cell vulvar carcinoma * world health organization performance status of 0-2 * adequate hematological function * adequate hepatic function * adequate renal function * negative pregnancy test for woman of childbearing potential * measurable disease by physical examination * tnm stage t2, any n, mo exclusion criteria: * vulvar cancer other than squamous cell carcinoma at biopsy * previous radiotherapy of the vulva, groins or pelvis * patients with metastasis limited to the pelvic lymph nodes, who can be primarily operated with curative intent * other diagnosis of malignancy or evidence of other malignancy for 5 years before screening for this study
efficacy of dx-ph probe in diagnosing extra-esophageal reflux disease

Conditions: GERD; Larynx Disease

Summary: the purpose of this study is to establish the clinical application of a new device that records ph changes in the hypopharynx. the investigators also aim to compare the consistency of distal esophageal ph with hypopharyngeal ph using both the "short" and the "long" catheters in patients.

gastroesophageal reflux disease (gerd) has been linked to many disorders and can be diagnosed through a variety of modalities utilizing 24 hour ambulatory ph monitoring which can register the duration, pattern and symptom correlation of distal esophageal acid exposure. this can be accomplished via a catheter probe connected from outside the body and placed through a nostril, advanced past the hypopharynx and down into the distal esophagus. or, a small ph detector temporarily implanted in the distal esophagus during endoscopy can record reflux events. however, despite available technologies, there has long been a deficiency in detecting extra-esophageal reflux in the upper esophagus/ hypopharynx. this is of interest for gastroenterologists, otolaryngologists, and pulmonologists in the evaluation of extra-esophageal reflux as a potential culprit for asthma, chronic cough, laryngitis, globus, and non-cardiac chest pain. until now, there has not been a device sensitive enough for accurately detecting extra-esophageal reflux (eerd) and clinicians have relied upon subjective response to empiric treatment with acid reducing medications to determine whether acid reflux was at the root of the symptoms. there are currently no well designed published studies with this device to assess its role in this group of difficult to treat patients.

Eligibility criteria:
inclusion criteria: 1. male and female volunteers aged 18 to 65 years old. 2. control group: no known history of gerd or eerd or prior ppi use. 3. gerd group: patients with known history of gerd based on prior response to either histamine inhibitors (h2 blockers) or proton pump inhibitors (ppis) and/or endoscopic esophagitis identified at endoscopy. 4. eerd group: patients with chronic cough, asthma and laryngeal findings felt to be gerd related. exclusion criteria: 1. use of h2 blockers or ppis within one week prior to and during the study for the gerd and eerd patients. no prior ppi use is allowed for the control population. 2. use of antacids (rolaids, tums, pepto-bismol, etc.) within one day prior to or during the study. 3. esophageal motility abnormalities (achalasia, esophageal spasm, severe dysphagia) 4. expected non-compliance. 5. positive history of ongoing alcohol or tobacco use and inability to refrain from using either during study duration (24 hours). 6. recent nasal surgery or nasal obstruction. 7. significant medical conditions that, in the investigator's judgment, would compromise the subject's health and safety (mental disability, psychiatric impairment, inability to read or comprehend the consent form) 8. pregnancy

Keywords: healthy volunteers
phacoemulsification in acute congestive glaucoma

Conditions: Glaucoma

Summary: acute primary angle closure (apac) is usually caused by an abrupt closure of the trabecular meshwork in the anterior chamber angle that leads to a sudden rise in intraocular pressure (iop). apac is a subgroup of angle closure disease characterised by a sudden onset of headache, blurred vision, seeing halos around lights, corneal oedema, mid-dilated pupil, eye pain and redness. asian also has a much higher incident rate of apac compare to the caucasian population - with the crude incidence rate of 12.2 and 10.4 per 100,000 people per year in the above 30-year-old population of singapore and hong kong, respectively . this is higher than the average incidence rate of 3.9-4.1 cases per 100,000 people per year in the european regions . in apac, both lpi and primary lens extraction by phacoemulsification and intraocular lens implant (phaco/iol) were demonstrated to be effective to control iop elevation. the latter has been shown to be the more effective treatment than lpi for iop reduction at the early and mid-term iop control. together with the advancement of phaco/iol technique, primary lens extraction is the more popular choice of treatment nowadays. however, operating on an eye with early aborted apac is technically challenging and may increase the risk of complications because of the presence of corneal oedema, inflammation, shallow anterior chamber, floppy iris and unstable lens. furthermore, "the best time window" for performing lens extraction after an apac attack remains uncertain. the long-term results (e.g. more than 5 years) of early lens extraction compared to the conventional lpi are also unknown. in this study, we summarise the approach of treating apac at the initial acute stage and review the studies that consider iop control in the mid and long term. we would also touch on the role of goniosynechialysis, trabeculectomy and endoscopic cyclophotocoagulation in treating apac, as well as considering the economic aspect of treatment. aim of the study: to evaluate the safety and efficacy of phacoemulsificatiojn in cases of acute congestive glaucoma


Eligibility criteria:
inclusion criteria: * patients with acute congestive glaucoma exclusion criteria: * people under 18 years
the impact of ketamine on postoperative cognitive dysfunction, delirium, and renal dysfunction

Conditions: Cognitive Disorders; Delirium; Acute Kidney Injury

Summary: ketamine is a commonly used anesthetic medication which is used for induction of anesthesia as well as as an analgesic. it has been shown to have anti-inflammatory properties which may decrease post-operative complications following cardiac surgery with cardiopulmonary bypass that are thought to associated with inflammation. some studies have shown that ketamine does decrease these complications when compared with anesthetics that are not commonly used in our cardiac anesthesiology practice. propofol is another commonly used anesthetic medication which is used for induction of anesthesia. ketamine has not been compared with propofol for potential to reduce post-operative complications associated with the inflammatory process. this study aims to see if ketamine will reduce the incidence of cognitive dysfunction, delirium, and renal dysfunction in comparison with propofol. in addition, the hemodynamic impact of ketamine compared propofol will be investigated.


Eligibility criteria:
scheduled to undergo cardiac surgery. inclusion criteria: * age greater than or equal to 75 years presenting for cardiac surgery at the mayo clinic in rochester, minnesota; * schedule to undergo complex cardiac surgery. complex cardiac surgery will be defined as surgery involving more than one heart valve, redo-sternotomy procedures, or combined valvular and cabg procedures. exclusion criteria will include: * left or right ventricular assist device implantation or explantation, * procedures not requiring cardiopulmonary bypass, * active infection or sepsis, severe hepatic disease or ascites, * pre-operative renal dysfunction including a baseline creatinine equal to or greater than 1.5 mg/dl or requiring dialysis, * immunosuppressive medication use (including steroid use), * immunodeficiency syndrome, * known neurologic or psychiatric disorder, or * use of drugs for psychosis.
isolation and authentication of mesenchymal stem cell-like progenitor cells from the degenerated intervertebral disc of lumbar spine

Conditions: Lower Back Pain; Disc Degeneration

Summary: the study is designed for evaluating the presence of mesenchymal stem cells of vertebral disc. isolation and authentication of these cells may be applied for the vertebral disc regeneration and the research tissue engineering.

we will collect the degenerative disc from adults and isolate the mesenchymal stem cell-like precursors cells. the function of osteogenic, chondrogenic, and lipogenic differentiation will be authenticated. the results will offer the information for cell source of tissue engineering in the future.

Eligibility criteria:
inclusion criteria: * the adults with disc degeneration（age \>= 20 years old） a. herniated intervertebral disc. b. spondylolisthesis. c. spondylolysis. d. other causes of disc degeneration. exclusion criteria: * age \< 20 years old. * pregnancy. * spinal tumors. * spinal infections.

Keywords: vertebral disc, mesenchymal stem cell.
acupuncture as a complementary treatment for hypertension (act-has)

Conditions: Hypertensive Disease

Summary: this is a randomized clinical trial with blinded, multi-center, involving the federal university of in rio de janeiro(ufrj), through the school of nursing anna nery, as a proponent and research coordinator; and as a collaborative educational institutions, the federal university of in espirito santo, represented by the department of nursing; and the higher school of sciences of the santa casa de misericordia of vitoria, developed by building doctorate thesis as a final product of the research.

the objective of investigation is the effectiveness of acupuncture as a complementary health care to patients with primary hypertension drug therapy. methodological approach - randomized clinical trial triple blind. population / sample - patients with primary hypertension in drug treatment for over a year and no effective control of blood pressure levels, that is, regular saving measures above was over 140x90 mmhg. how centers participants research, the study covers health units of the municipal health of maricá in rio de janeiro, the municipal of victoria health in espirito santo, beyond the scope of integrated project research-service (pipa), linked to school nursing anna nery /ufrj. primary objective - to evaluate the effectiveness of acupuncture as a complementary health practice associated with drug treatment used in adults with primary hypertension, based on nursing diagnoses. secondary objectives: * estimate blood pressure levels after exposure to acupuncture applied in adults with primary hypertension. * draw the profile of the most frequent nursing diagnoses in adults with primary hypertension. * analyze the effectiveness of acupuncture as a complementary health therapy associated with drug treatment used on these clients, based on nursing diagnoses.

Eligibility criteria:
inclusion criteria: * be suffering from essential hypertension; * be properly prescribed medication and have difficulty controlling blood pressure keeping regular measurement above was over 140x90 mmhg. exclusion criteria: * a woman in pregnancy; * be in possession of any type of cancer; * being a smoker; * be alcoholic; * be in drug treatment for other diseases including obesity; * not dieting for weight loss; * practice regular physical activity.
cb-prp in retinitis pigmentosa and dry age-related macular degeneration

Conditions: Retinitis Pigmentosa; Dry Age-related Macular Degeneration

Summary: the study will provides the enrollment of patients with genetic retinal dystrophies with primary rod impairment and dry age-related macular degeneration (geographic type) a subretinal injection of umbilical cord blood platelet-rich plasma (cb-prp) will be performed only in one eye, the other eye will be considered as a control group. a complete morpho-functional ophthalmological evaluation will be performed in all patients at each control.

all patients underwent genetic evaluation and they reported different types of mutations that induce anatomic-functional impairment of the rods. patients affected by bilateral dry age-related macular degeneration (geographic type) will be recruited as well. after selecting the patients to be enrolled, the study will proceed with the vitrectomy surgery and subretinal injection of umbilical cord blood platelet-rich plasma (cb-prp) provided by the umbilical cord bank according to the procedures provided for by the current legislation on blood components for non-transfusion use. a complete ophthalmological examination will be performed at 1, 3, 6, and 12 months. they will include: * anterior segment biomicroscopy * direct and indirect ophthalmoscopy * etdrs visual acuity assessment * intraocular pressure measurement * optical coherence tomography (oct) * oct angiography (octa) the following assessments will be performed at baseline and at 6 and 12 months. * microperimetry * electroretinogram (erg) * visually evoked potential (vep) * contrast sensitivity (mars tables) * goldmann perimetry some morpho-functional data will also be collected in the contralateral eye and used as the control group. to ensure the best safety for the patient, the first 5 eyes will be separated by a minimum of 20 days in order to observe the post-surgical evolution.

Eligibility criteria:
inclusion criteria: * retinal dystrophies with compromised rods (only for rp patients) * visual field (manual goldmann) v / 4e \< 30 ° (only for rp patients) * best corrected visual acuity \> light perception * known genotype * no or minimal opacity of ocular media * no concomitant ocular (eg glaucoma, amblyopia) * dry age-related macular degeneration (geographic type) exclusion criteria: * age\<18 years * pregnancy * previous inflammatory / infectious events involving the eyes

Keywords: cord blood platelet-rich plasma retinitis pigmentosa dry age-related macular degeneration macular geographic atrophy