Kornimate/medical-research-clean huggingface dataset:
the effect of exercise on cognitive status in older adults

Conditions: Older People

Summary: the purpose of the study is to demonstrate the effectiveness of the different combinations of exercises on the cognitive status of older adults with cognitive decline.

this study is planned to examine the effects of combined exercise on cognitive status, lower extremity muscle strength, mobility, physical performance, mood and quality of life in older adults with mild cognitive impairment. aerobic exercise training and lower limb (extremity) strengthening exercises were applied to the first group, dual-task training and lower limb strengthening exercises were applied to the second group, and aerobic exercise training, dual-task training and lower limb strengthening exercises were applied to the third group.

Eligibility criteria:
inclusion criteria: * not had a fall in the last six months. * older adults with an mini mental state examination score between18-23. * age ≥ 65years. exclusion criteria: * having central nervous system pathology that will affect balance * diagnosed with vestibular pathology, * having deformities in the waist, hip, and knee joints, * having lower extremity amputation, * with lower extremity operation history, * malignancy affecting the lower extremity, * having moderate and severe congenital heart disease, coronary heart disease and cerebrovascular disease, * participants who cannot cooperate, * participants who use an assistive walking device, * participants having vision problems.
evaluation of a website on living kidney donation for hispanics

Conditions: End Stage Kidney Disease

Summary: the purpose of this study is to increase understanding about living kidney donation (lkd) among hispanic/latino patients and public by increasing knowledge and positive attitudes about lkd. improving hispanics' understanding about lkd will ensure that hispanic patients and public are fully informed of the treatment options for end stage kidney disease.

the shortage of kidneys for transplantation, and ethnic disparities in living kidney donation rates are major public health problems. hispanics need more kidney transplants, yet receive fewer living donor kidney transplants than they need. factors known to contribute to hispanics' low rates of living donation kidney transplantation include cultural beliefs, lack of knowledge, and negative attitudes about living kidney donation. web-based interventions are promising as hispanics are using the internet at increasingly greater rates. however, few websites about transplantation are tailored to potential hispanic kidney transplant candidates or the hispanic community. this study aims to develop, test, and evaluate the effectiveness of a bilingual web-based educational resource targeted to hispanic patients and the public, which can serve as a low-cost, convenient, and culturally competent tool to enhance knowledge about living kidney donation. improving hispanics' understanding about living kidney donation will promote their autonomy and self-determination by helping to ensure that hispanic patients and public are fully informed of the treatment options for end-stage kidney disease.

Eligibility criteria:
inclusion criteria: * adults (age ≥ 18 years) * hispanics/latinos * esrd patients who are scheduled to attend each participating transplant center's education sessions. sessions mark the first phase of evaluation in order for patients to get wait listed for a transplant or for others to become a living kidney donor. * family and friends who accompany patients to the transplant center. * identification as hispanic/latino. * ability to come to northwestern 3 hours prior to the scheduled education session. * ability to read. reading ability will be assessed using the 5-point likert scale question validated in english and spanish:13 "how often do you need to have someone help you when you read instructions, pamphlets, or other written material from your doctor or pharmacy?" people will be included if they reply 1-never or 2-rarely. exclusion criteria: * non-identification as hispanic/latino. * inability to come to northwestern 3 hours prior to the scheduled education session. * individuals who are not able to read spanish or english. people will be excluded if they reply 3-sometimes, 4-often, and 5-always to the question, "how often do you need to have someone help you when you read instructions, pamphlets, or other written material from your doctor or pharmacy?" .

Keywords: living kidney donation end-stage renal disease latinos undocumented immigrants bilingual spanish website dialysis hispanics transplantation
diagnostic performance of psma pet/ct for pre-operative lymph node assessment in intermediate and high-risk non-metastasic prostate cancer (preop-psma ).

Conditions: Prostate Cancer

Summary: in france, prostate cancer is the most common cancer in men over 50 years of age (nearly 50,000 new cases per year) and is the second most common cause of cancer death in men (approximately 9,000 deaths per year). although mortality has been declining since the end of the 1990s (about 7%/year), about 30 to 35% of them will have a biological recurrence. accurate assessment of local, regional and distant spread of the disease is therefore needed to design optimal personalised care for each patient, either curative or palliative. currently, in france, recommended disease assessment includes bone scintigraphy and abdomino-pelvic magnetic resonance imaging. however, conventional imaging has limited performance with regard to lymph node extension. node dissection is the best way to assess node status. currently, no imaging exam allows this level of accuracy. recently, molecular imaging has emerged as a promising tool to improve the initial extensional assessment of prostate cancer. prostate-specific membrane antigen (psma) is a transmembrane glycoprotein, specific to the prostate, which is over-expressed on the surface of prostate cancer cells. recent studies of psma pet/ct as part of the initial extension assessment of prostate cancer report superior diagnostic performance in terms of sensitivity and specificity compared to conventional tests, as well as an impact of psma pet/ct on patient management.


Eligibility criteria:
inclusion criteria: * histologically confirmed prostate cancer; * intermediate-risk prostate cancer (psa level of 10- 20 ng/ml and/or clinical tumor stage ≥ t2b and/or isup 2 or 3, and with risk of lymph node extension \> 5% according to the briganti nomogram) or high-risk prostate cancer (psa ≥ 20 ng/ml and/or tr ≥ t2c and/or isup 4 or 5) according to d'amico classification; * curative treatment by radical prostatectomy chosen by the multidisciplinary consultation meeting. exclusion criteria: * refusal or inability to participate in the study ; * low-risk prostate cancer according to d'amico's classification, or an intermediate-risk but with a risk of lymph node extension \<5% according to briganti's nomogram; * curative treatment other than surgical treatment chosen; * life expectancy \< 12 months; * karnofsky score \ 2.
brachial artery peak velocity variation to predict fluid responsiveness

Conditions: Hypotension; Shock

Summary: the investigators designed this study to determine the predictive value for predicting fluid responsiveness of noninvasive evaluation of respiratory variation of peak velocity in brachial artery, in mechanically ventilated patients with acute circulatory failure.

predicting the hemodynamic response to fluid administration (or fluid responsiveness) in critical ill patients is still a matter of concern, since fluid overload could worse the clinical situation of these patients. parameters of fluid responsiveness usually require an invasive monitoring (like arterial pulse pressure variation). we hypothesize that noninvasive evaluation of respiratory variation of peak velocity in brachial artery using doppler ultrasound could provide a feasible estimation on fluid responsiveness in mechanically ventilated patients with acute circulatory failure.

Eligibility criteria:
inclusion criteria: * patients with controlled mechanical ventilation, equipped with an indwelling radial artery catheter and for whom the decision to give fluids will be taken because the presence of one or more clinical signs of acute circulatory failure: * systolic blood pressure \ 50 mmhg in previously hypertensive patients) * the need of vasopressor drugs * oliguria (urine output \<0.5 ml/kg/min for at least 2 h) * tachycardia * delayed capillary refilling * the presence of skin mottling exclusion criteria: * contraindication for the volume administration: evidence of fluid overload and/or of hydrostatic pulmonary edema * patients with instable cardiac rhythm

Keywords: fluid responsiveness ultrasound cardiac output
the effect of fluoride varnish on white spot lesion in clear aligner orthodontic patients

Conditions: White Spot Lesion

Summary: fluoride varnish is being applied on the teeth surfaces of patients undergoing orthodontic treatment just before receiving their clear aligners. the effect of the varnish was investigated if it can reduce the incidence of enamel demineralization or not.

background: the preventive effect of fluoride varnish on the development of white spot lesions (wsls) during clear aligner treatment has not been investigated in the literature. hence this was the purpose of this study. material and methods: this was a prospective double-blinded randomized clinical trial. a total of 44 patients (7 males, 37 females, with a mean age of 20.91 ± 4.56) who sought clear aligner therapy at the postgraduate orthodontic clinics at just were recruited and randomly divided equally (n=22 in each group) by a website randomizer. eligibility criteria included healthy patients of both sexes (age range 14-30 years), class i malocclusion with mild-to-moderate crowding (≤5 mm), non-extraction treatment plan, and optimum oral hygiene before treatment. both the patient and the investigator were blinded during the intervention and assessment of outcomes. at (t0) fluoride varnish was applied to the subjects in group 1, while normal saline was applied to the subjects in group 2 as a control. quantitative light-induced fluorescence (qlf) images were taken at the start of the treatment (t0) and after 4 months (t1). the qlf images were analyzed to assess the primary outcomes: lesion area (pixels), the mean amount of fluorescence loss (δf)% in addition to the number of newly developed lesions.

Eligibility criteria:
inclusion criteria: * healthy subjects form both sexes * mild to moderate crowding * optimum oral hygiene * maximum of three restored teeth exclusion criteria: * presence of enamel hypoplasia or hypocalcification, * any salivary gland disease or medication use that affect the salivary flow * subjects using fluoride other than 1450 ppm fluoride toothpaste.

Keywords: fluoride varnish clear aligners white spot lesions quantitative light induced fluorescence (qlf)
precoca - "prehospital cooling with cool-caps"

Conditions: Heart Arrest

Summary: this study shall investigate the feasibility of the use of cool-caps in the preclinical setting in patients with successful primary cardio-pulmonary resuscitation hypothesis: cool-caps are efficient and feasible to use in the preclinical setting in patients after successful cpr.


Eligibility criteria:
inclusion criteria: * all patients with primary successful cpr exclusion criteria: * age \< 18 * pregnancy * severe bleeding or severe trauma * body core temperature \< 34 degrees celsius

Keywords: primary successful cardio-pulmonary resuscitation pre-hospital setting
reduced intensity fludarabine and tbi prior to haplo-identical transplantation

Conditions: Hematologic Malignancy

Summary: this trial will evaluate the safety and efficacy of ric hidt transplant protocol following fludarabine and intermediate-dose tbi 800 cgy utilizing pbsc as the stem cell source.


Eligibility criteria:
inclusion criteria: * availability of 3/6 - 5/6 matched related donor with a negative hla-cross match in the host vs. graft direction willing to donate peripheral blood stem cells * kps \>/= 70% * hematologic malignancy requiring allogeneic transplantation, with a predicted high risk of relapse following non-myeloablative, low intensity conditioning. exclusion criteria: * poor cardiac function (lvef \<45%) * poor pulmonary function (fev, fvc, dlco \<60%) * poor liver function (bilirubin \>/= 2.5mg/dl; ast or alt \>3xuln) * poor renal function (creatinine clearance \<40ml/min) * hiv-positive; active hepb or hepc * uncontrolled infection * pregnant female or not able to practice adequate contraception * debilitating medical or psychiatric illness which would preclude their giving informed consent
intranasal dexmedetomidine premedication

Conditions: Benign Neoplasm of Vocal Fold - Glottis

Summary: most patients with preoperative varying degrees of stress, anxiety, which makes the stress response in patients and affect the normal conduct of anesthesia and surgery.the sympathetic system hyperexcitability prone to cause adverse cardiovascular events and affect postoperative recovery. however, phenobarbital, as the traditional premedication, has less sedative, weak anxiolytic and other shortcomings. midazolam accompanied by inhibition of respiration,excessive sedation, easily induced delirium,prolonged recovery time and so on. dexmedetomidine is a highly selective α2-adrenergic receptor agonist, it has sedative, anxiolytic, no inhibition of respiration, and also colorless, odorless, non-mucosal stimulation, nasal drip ease of administration, patient acceptance, comfortable. therefore, dexmedetomidine as premedication has certain advantages. the purpose of this research is to study sedative effect, safety and the impact of anesthesia recovery period of intranasal dexmedetomidine premedication for suspension laryngoscopy.

all patients received intranasal dexmedetomidine (1μg.kg-1) or placebo at approximately 45 min before induction of anesthesia.the study drug was prepared in a 1-ml syringe.an equal volume of dexmedetomidine or placebo was dropped into each nostril by a blinded research assistant in the supine position.automatic sphygmomanometer measure blood pressure.oxygen saturation and heart rate were measured by a pulse oximeter. respiratory rate, sedation score and anxiety levels regularly assessed. patients with general anesthesia, suspension laryngoscopy surgery and postoperative care, standard monitoring are unified.

Eligibility criteria:
inclusion criteria: * surgery:the laryngoscope vocal polyp excision * aged 18 to 60 years old * body mass index (bmi) \< 30 kg/m2 * american society of anesthesiologist (asa) i -ii exclusion criteria: * the investigator refused to participate * known allergy or hypersensitive reaction to dexmedetomidine or anesthetic * with previous history of heart disease * pregnant women; no reliable contraceptive measures in postmenopausal women * preoperative heart rate less than 45bpm; ⅱ or ⅲ degree atrioventricular block; ischemic heart disease * taking antihypertensive drugs such as methyldopa, clonidine and other α2 receptor agonist * asthma * sleep apnea syndrome * liver and kidney dysfunction * known to suffer from mental illness * long-term use of sedatives and analgesics in patients

Keywords: intranasal dexmedetomidine early recovery suspension laryngoscopy
med diet prevention metabolic syndrome men undergoing androgen deprivation therapy prostate cancer

Conditions: Prostate Cancer

Summary: the purpose of this study is to assess for changes in a patient's overall energy level and well-being (quality of life) after 8 weeks of dietary intervention.

primary objective: to assess for changes in the following measurements after 8 weeks of following a mediterranean diet-- ldl, hdl, tg, fbs, creatinine, serum testosterone, triglycerides, serum insulin, crp, 1bs, waist circumference, blood pressure, body weight

Eligibility criteria:
inclusion criteria: * histologically documented carcinoma of the prostate * on treatment with androgen deprivation therapy for at least 3 months * required laboratory values: * serum creatinine less than 2.5 * triglycerides \<300 * fasting glucose \< 126 * testosterone level \<50 exclusion criteria: * no diabetes mellitus (type 1 or 2) * no renal failure (serum creatinine \> 2.5) * no active cardiac disease -no history of myocardial infarction/stroke within the last 12 months, no recurrent unstable angina, uncontrolled/unstable arrhythmias, uncontrolled hypertension (systolic blood pressure \>160, diastolic blood pressure \>100) * no severe peripheral vascular disease * no commencement of lipid lowering agent within 8 weeks of enrollment the study or change in dose throughout the study
identify coronavirus disease by chest x-ray

Conditions: Coronavirus Disease 2019

Summary: to identify the diagnostic accuracy of chest x-ray in diagnosis of coronavirus disease19 .

the pandemic related to the coronavirus is now considered one of the deadliest epidemics. the numbers of cases exponentially increased with no specific treatment, creating havoc for the health and financial systems of the world \[1-6\]. wuhan, the capital city of hubei in china, reported the earliest cases that were treated as an unusual pneumonia. with the disease progression, the world health organization (who) announced the presence of several similar cases \[7, 8\]. researchers revealed that a novel strain of the family coronaviridae is the pathogen responsible for the respiratory illness of this disease and this is simulating two previous epidemics, namely mers (middle eastern respiratory syndrome) and sars (severe acute respiratory syndrome). the disease induced by sars-cov-2 was labelled as covid-19 by the international classification of diseases (icd) \[9\]. chest radiographs are usually of limited value in the diagnosis of early stages especially in mild disease course; however, the ct findings may be present early even before the onset of the symptoms. chest radiographs is very helpful in the intermediate to advanced stages of covid-19 with features of acute respiratory distress syndrome (ards) as well as the follow-up \[10-11\]. this study to determine the covid-19 disease course and severity using chest x-ray (cxr) scoring system and correlate these with patients' age, sex, and outcome.

Eligibility criteria:
inclusion criteria: * all individuals attending the radiodiagnosis department , who had paired posterior-anterior chest radiographs and rt-pcr nasopharyngeal swabs for covid-19 at the time of initial attendance with moderate to advanced stage. * the patients have positive finding in the posterior-anterior chest radiographs , multislice computer tomography and rt-pcr nasopharyngeal swabs for covid-19. * the patients with positive finding in the laboratory investigation (cbc, crp ,esr , s.ferritin \& d-dimmer) . * patients with positive chest-ct finding and laboratory finding despite of having negative pcr swab exclusion criteria: * patients exceeding 30 days after positive rt-pcr . * patients diagnosed with mediastinal lymphadenopathy , masses ,tree in bud appearance ,pneumothorax. or cavitation.
randomized controlled study of the efficacy of hypnosis versus relaxation and control in neuropathic pain

Conditions: Neuropathic Pain

Summary: a randomized double-blind controlled two centers study. the primary objective of this study will be to show a superiority of hypnosis over relaxation on pain intensity in patients with neuropathic pain.

the secondary objectives of this study are: * to show a superiority of hypnosis and relaxation over control group on neuropathic pain. * to show a lasting effect of treatment on neuropathic pain one week after the end of treatment. * to evaluate the clinical predictors of response to hypnosis (nature of neuropathic symptoms, severity of anxiety and depressive symptoms, pain catastrophizing, coping strategies, emotional regulation, response to the first session, positive or negative emotional reaction at the end of hypnosis sessions). * to evaluate the effect of hypnosis at long-term (1, 3 and 6 months after the end of treatment). * to evaluate the effect of hypnosis on emotional processes. * to compare hypnosis to relaxation on short-term effects on pain, * to evaluate the quality of life and the impact of pain on daily life: sleep, mood, anxiety symptoms, analgesics consumption , neuropathic symptoms, affective component of pain and pain catastrophizing. 35 patients will be enrolled in each arm, to obtain 105 in total (3 arms). total duration for each patient: 8 months.

Eligibility criteria:
inclusion criteria: * peripheral or central neuropathic pain, probable or definite * diagnostic questionnaire score dn4 ≥ 4/10 * chronic pain with an average of pain intensity greater than or equal to 4/10 (digital scale) * presence of daily or almost daily pain (i.e. at least 4 days per week) * patient with pre-existing pain for \> 6 months * patient \> 18 and \< 60 years old * patient with a stable analgesic treatment since 15 days before inclusion * patient able to participate to the trial during 33 weeks * patient having a health insurance * written informed consent signed by the patient. exclusion criteria: * prior treatment with hypnosis * currently under active psychotherapy (cognitive-behavior therapy, psychoanalysis) * work accident or litigation * drugs abuse or psychoactive substance abuse (dsm-iv) * neuropathic pain associated with progressive disease (ms, hiv, cancer ...) * major depression with ongoing disability or psychosis (dsm iv) * intermittent pain * patient with pre-existing pain for \< 6 months * other more severe pain than the pain justifying inclusion * subject unable to understand the trial information provided in the informed consent document * subject under curators or guardianship * severe handicap or amputation * participation to another study in the same period * deafness * cognitive disorders (dementia, mild cognitive impairment, inability to understand the questionnaires) * for patients of the control arm: treatment by hypnosis and / or relaxation, transcranial magnetic stimulation, or invasive treatments (surgery)

Keywords: neuropathic pain hypnosis relaxation