Kornimate/medical-research-clean huggingface dataset:
project to use community health workers to reduce maternal deaths

Conditions: Maternal Mortality; Access to Health Care

Summary: the purpose of this trial is to establish if several interventions will help women in rural tanzania access health care services during pregnancy and at the time of delivery. the interventions include education about the importance of attending antenatal care visits with nurses and facility deliveries, a voucher for transport to access the health facility at the time of delivery, and supplies to be used either at the health facility, or on route if the women does not make it to the health facility.

in order to reduce the number of women dying in childbirth and to improve women's health in pregnancy, this trial is designed to assess if several interventions combined can increase the number of women delivering in health care facilities. the design of the study is "multiple baseline design". community health workers are trained to collect baseline data on women using mobile phones in one rural district in tanzania. the district has four distinct divisions. after 6 months of baseline data in the district, one division will experience the interventions. the interventions are education about the importance of attending antenatal care visits with nurses and facility deliveries, a voucher for transport to access the health facility at the time of delivery, and birthing supplies to be used either at the health facility, or on route if the women does not make it to the health facility. the intervention will be begun in each of the other divisions in 3 month intervals (i.e. the second division starts to experience the interventions 3 months after the first, the third, 3 months after the second and the fourth 3 months after the third). the trial will continue for a total of 27 months including the baseline period.

Eligibility criteria:
inclusion criteria: 1. women must be pregnant. 2. women must live in rorya district, but not in shirati town. 3. women must deliver in rorya district . exclusion criteria: 1. women who live outside or deliver outside of rorya district. 2. women who deliver preterm, before they have exposure to all the interventions.
the effect of loading dose of magnesium sulfate on uterine, umbilical, and fetal middle cerebral arteries doppler, biophysical profile, ctg, maternal vital signs in women with severe preeclampsia

Conditions: Preeclampsia

Summary: 100 women with severe preeclanpsia received magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. resistance index \[ri\], pulsatility index \[pi\] and systolic/diastolic \[s/d\] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes

100 women with severe preeclanpsia received magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. resistance index \[ri\], pulsatility index \[pi\] and systolic/diastolic \[s/d\] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes

Eligibility criteria:
inclusion criteria: * singleton pregnancy. * primigravida or multigravida. * pregnant females ≥ 37 weeks of gestation. * diagnosed as severe preeclampsia by the following criteria: * sustained systolic blood pressure of ≥160 mmhg or a sustained diastolic blood pressure of ≥ 110 mmhg. * proteinuria measured as +1 or more by dipstick or 24 hours urine collection with proteinuria ≥ 0.3 grams. * oliguria or creatinine \> 1.1 mg%. * laboratory findings characteristic of hellp syndrome. * symptoms suggestive of severe preeclampsia ; severe headache, blurring of vision, epigastric pain. exclusion criteria: * multifetal pregnancy. * history of epilepsy. * patients with diabetes. * patients with renal disease. * fetuses with congenital anomalies. * patients receiving anticoagulants e.g. heparin (unfractionated or low molecular weight). * patients with severe iugr. * patients with accidental hemorrhage.
studying biomarkers in samples from younger patients with wilms tumor

Conditions: Kidney Cancer

Summary: rationale: studying samples of blood, tissue, or bone marrow from patients with cancer in the laboratory may help doctors to learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this research trial studies biomarkers in samples from younger patients with wilms tumor.

objectives: * to analyze 250 favorable-histology wilms tumor (fhwt) samples from patients registered on nwts4 for gain of 1q and 15q, and loss of 1p, 16q, 17p, and 22q by subtelomeric multiplex ligation-dependent probe amplification (mlpa), and to determine their association with relapse-free and overall survival. * to develop a robust multiplex mlpa test using multiple synthesized probes to those targets identified as significantly associated with relapse in aim 1. * to validate the multiplex mlpa test designed and tested in aim 2 on an independent set of 1727 fhwt and 250 anaplastic wt registered on nwts-5. outline: archived dna samples are analyzed for gain of 1q and 15q, and loss of 1p, 16q, 17p, and 22q by mlpa. assay results are then researched for accuracy, clinical validity, sensitivity, precision, and potential analytical interferences.

Eligibility criteria:
disease characteristics: * dna samples from fhwt patients registered on: * nwts-4 * nwts-5 with focal and diffuse anaplasia tumors patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: wilms tumor and other childhood kidney tumors
effect of new oral treatment for hepatitis c virus on seminal parameters

Conditions: Male Infertility; HCV

Summary: hepatitis c virus is commona viral infection. direct-acting antiviral (daa) oral drugs has been used in treatment of hcvs. the effect of these drugs on male infertility is still under investigation.

semen analysis will be done to male patients with hcv before and after treatment with daa. the included men will take therapy for 3 months and hcv rna titter will be evaluated. changes of seminal parameters will be recorded and analyzed.

Eligibility criteria:
inclusion criteria: men patients with hcv exclusion criteria: patients with other hepatic disease, endocrinal disorder, malignancy, or urinary tract infection.

Keywords: semen daa male infertility
stress, anxiety and type a personality and analgesics

Conditions: Postoperative; Dysfunction Following Cardiac Surgery

Summary: patients scheduled for elective cardiac surgery are preoperative evaluated using different personality type, stress and anxiety tests. patient are randomized to receive the investigators' standard moderate dose sufentanil (bolus 1microgram/kg and propofol 0.03 mg/kg/min) or low dose sufentanil (bolus 0.5 microgram/kg and propofol 0.06 mg/kg/min).

patients randomized and the type of induction informed to the anaesthetist 30 minutes before surgery. patients are monitored before induction of anesthesia. propofol is started on the randomized infusion rate. sufentanil bolus are given according to randomization. bis level is followed. time to reach bis \< 50 is monitored. bis after 30, 60 and 90 minutes are registered. lowest bis during surgery are registered. total amounts of sufentanil and propofol recorded.

Eligibility criteria:
inclusion criteria: * all elective cardiac surgery patients exclusion criteria: * patients requiring special attention or monitoring during induction * patients with expected longer postoperative ventilation time * patients allergic to sufentanil and or propofol * participation in other projects * pregnancy

Keywords: sufentanil propofol personality/stress test fast-track
investigating composite biomarkers for pain catastrophizing

Conditions: Pain, Acute

Summary: pain is a complex, multidimensional, and subjective experience; and although, investigators use a single word "pain", to describe our perception, multiple mechanisms contribute to the generation and maintenance of pain. to help diagnosing and improving pain management, there is a need for developing tools. these tools may include measurements of substances, or biomarkers, in the blood; e.g. small molecules called microrna and proteins. in these experiments, the investigators would like to investigate how the psychological response to stress and pain alters the impulses in the brain and the content of microrna and proteins in the blood. the future aim is to identify patients in high risk of developing and maintaining chronic pain and to be able to treat chronic pain efficiently.


Eligibility criteria:
inclusion criteria: * healthy men and women in the age 18-80 years * speak and understand english exclusion criteria: * acute and chronic pain * pregnancy or breastfeeding * drug addiction defined as the use of cannabis, opioids or other drugs * present or previous history of neurological, dermatological, immunological, musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.) * focal and generalized seizure * surgery or any other therapy for epilepsy * present or previous aeds (anti-epileptic drugs) administration * present or previous use of epileptic devices (\<1 year prior the enrolment) * lack of ability to cooperate * current use of medications that may affect the trial, such as antipsychotics and pain killers as well as systemic or topical steroids and anti-inflammatory drugs. * skin diseases * consumption of alcohol or painkillers 24 hours before the study days and between these * participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
revisiting parental survey for screening for obstructive sleep apnea in patients undergoing polysomnography

Conditions: Sleep Apnea

Summary: the investigators are proposing a study where the investigators would give a survey to the parents of patients having a sleep study. the survey would contain questions relating to symptoms of sleep apnea and then the investigators would correlate the parent answers to the results of the sleep study.


Eligibility criteria:
inclusion criteria: * any patient coming for sleep study at nationwide children's hospital and parent willing to fill out questionnaire. * children ages 3-18 years old regardless of sex or race. exclusion criteria: * parental refusal.

Keywords: sleep study nch
the effect of functional electrical stimulation on gait and balance in children with hemiplegic cerebral palsy

Conditions: Cerebral Palsy

Summary: the aim of this study will be to evaluate the effect of fes on stimulation of the anterior tibial group by using the walkaide foot drop stimulator on improving walking and balance abilities in children with hemiplegic cp.

the aim of this study will be to evaluate the effect of fes on improving walking and balance abilities in children with hemiplegic cp. forty children with hemiplegic cp will be assigned randomly into two groups (a \& b). control group (a) will receive conventional rehabilitation program for lower limb, balance and gait training. study group (b) will receive conventional rehabilitation program as in group (a) in addition to fes by using the walkaide foot drop stimulator. patients' evaluation will be carried out before and after training to assess walking ability and balance performance.

Eligibility criteria:
inclusion criteria: * their weight should be less than 40 kg. * the spasticity degrees of the affected lower limb will range between grades (1, 1+ \& 2) according to modified ashworth scale (mas). those children functioning scores at gross motor function classiﬁcation system (gmfcs) levels i and ii. * they can walk 10 min conditionally without an orthosis. * ought to be intellectually skilled and ready to comprehend and take after directions. * they will have neither serious nor recurring medical complications. * children's height will be more than 100 cm to fit with the biodex balance equipment that will be used in this study to evaluate balance performance. * no serious hip \& knee flexion tightness will be present. knee flexion at starting contact should be between 20-40º . * peroneal nerve and the proximal leg muscles ought to be in place. * they ought to have no significant issues influencing balance other than spasticity. exclusion criteria: * children who demonstrate skin diseases or allergic reactions to adhesive tape or any other materials used in this study. * children with visual, auditory or perceptual deficits. * children with surgical interference for the lower limb. * children with seizures or epilepsy. * children who received botulinum toxin in the lower extremity musculature during the past 6 months or who wish to receive it within the period of study, other spasticity medication within 3 months of pre-treatment testing . * children with pacemakers or other diseases that are contraindicated by electrical stimulation.
spine of caregivers of children with cerebral palsy

Conditions: Cerebral Palsy; Spine Deformity

Summary: the purpose of this study was to assess pain (rest, activity, and night pain using the visual analog scale), disability (neck using the neck disability index; lumbar using the oswestry disability index), and curvature (cervical, thoracic, and lumbar using the spinal mouse) in primary caregivers of children with cerebral palsy.


Eligibility criteria:
inclusion criteria: * primary caregiver between the ages of 25-54 * has a child diagnosed with cerebral palsy between the ages of 0-18 * does not have inflammatory pain * without pain originating from abdominal-pelvic organs * volunteer caregivers were included exclusion criteria: * having acute fracture and malignancy * had a surgical operation (related to spine disorders) * having a care burden for more than one disabled individual * caregivers with chronic illnesses (such as neurological, psychological disorders) were excluded

Keywords: primary caregivers pain disability
chronic life stress and incident asthma in adult women

Conditions: Asthma; Lung Diseases

Summary: to prospectively examine the association between a specific chronic life stressor (i.e., intimate violence exposure) and adult asthma in women.

background: etiologies of the rising prevalence and morbidity of asthma are not well understood. knowledge gaps are particularly significant with respect to adult-onset asthma. the role of stress in the expression of asthma is largely unexplored in large-scale, prospective, epidemiologic studies and such investigation has been identified as a priority by a recent nhlbi expert panel. design narrative: the study prospectively examines the association between a specific chronic life stressor (i.e., intimate violence exposure) and adult asthma in women participating in the nurses' health study ii cohort. emerging epidemiologic data suggest that exposure to intimate violence is a pervasive chronic life stressor associated with adverse impact on womens' psychological and physical health. traumatic stress such as that related to intimate violence exposure has been associated with neuroendocrine changes known to cause alterations in neuroendocrine and immune functions important to the pathophysiology of inflammatory diseases including asthma. the investigators are testing the hypothesis that women exposed to high-level chronic stress (violence) will be at greater risk for asthma development than women with low-level stress (violence) exposure. the influence of chronic stress on neuroendocrine and immune function as reflected in morning cortisol expression, for the former, and cytokine profiles and ige production (t-helper cell polarization), for the latter, will also be examined in a nested case control fashion among these women. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
pathogenesis of postoperative infections and biomarkers for early diagnosis of it

Conditions: Complication of Surgical Procedure; Infections

Summary: infections remain a prevalent complication after major abdominal surgery. the common belief that most surgical site infections (ssis) following elective surgery with modern antiseptic techniques are due to intraoperative contamination is still not confirmed. therefore, alternative mechanisms for ssi development, such as the trojan horse theory-which suggests that pathogens from distant sites like the gastrointestinal tract may cause postoperative infections-should be explored. this study aims to analyze the preoperative microbiome of surgical patients' gut and oral cavities and assess whether microorganisms found there are present at the infection site. additionally, this study will investigate a panel of biomarkers for predicting postoperative infections.

infections remain a significant concern following major abdominal surgery. the prevailing notion that most surgical site infections (ssis) after elective surgery with modern antiseptic techniques are solely caused by intraoperative contamination remains unconfirmed. therefore, alternative mechanisms for ssi development, such as the trojan horse theory-which suggests that pathogens from distant sites like the gastrointestinal tract may contribute to postoperative infections-require thorough investigation. this longitudinal observational study aims to either support or challenge the trojan horse theory. this study will enroll patients undergoing major abdominal surgery for confirmed or suspected cancer. biological samples from stool, the oral cavity, and infection sites will be collected for sequencing and microbiome analysis to evaluate the presence of pathogens potentially responsible for postoperative infections originating from the gastrointestinal tract. additionally, blood samples will be collected to identify predictive biomarkers associated with the development of postoperative infections.

Eligibility criteria:
inclusion criteria: 1. the patient is scheduled to undergo a major resection-type abdominal surgery due to cancer of the esophagus, stomach, pancreas, liver, bile ducts, colon or rectum. 2. patient is willing to participate. 3. age ≥ 18 years. exclusion criteria: 1. pregnancy. 2. previous surgical resection of the digestive tract, excluding appendectomy and/or cholecystectomy. 3. anticipated operation with preventive ileostomy. 4. the operation is planned to be performed as a matter of urgency. 5. antibiotic therapy ≤1 month. before surgery. 6. chronic inflammatory bowel disease (non-specific ulcerative colitis, crohn's disease) or radiation or other colitis of origin. 7. during the last year, the patient suffered from cl. difficile colitis or was cl. difficile carrier, had salmonellosis or others intestinal infections. 8. during the last year, the patient used (\> 3 months) pre-/pro-/(syn)biotics. 9. during the last year, the patient has been taking proton pump inhibitors continuously (\> 6 months).

Keywords: microbiota surgical oncology gastrointestinal cancer postoperative complications biomarkers
development and verification of a new coronavirus multiplex nucleic acid detection system

Conditions: COVID-19

Summary: our project intends to independently develop a fully enclosed rapid detection system for a total of 22 pathogens, including sars-cov-2, on the basis of the qiastat-dx fully automatic multiple pcr detection platform. the reasonably designed experiments are used to verify the performance of the cartridge detection and prove its clinical application value. the 22 pathogens tested in this project includes 4 coronavirus subtypes, a / b flu, parainfluenza virus, respiratory syncytial virus, etc., which is of great significance for the differential diagnosis of similar patients.

covid-19 has not been well suppressed, and became a pandemic within 3 months globally is mainly because of the virus characteristic in the following aspects: 1. long incubation period (average 5-7 days, up to 28 days), and the incubation period is contagious 2. strong transmissibility, virus can be transmitted through aerosol 3. difficulty distinguishing infected patients from other pathogenic infections 4. high negative rate of nucleic acid detection in upper respiratory tract samples of infected patients, which increases the difficulty of differential diagnosis of infection with other pathogens the existing rt-pcr nucleic acid detection kits for sars-cov-2 has two major problems. first, the procedure is not automated leading to higher requirements for personnel operation level and environment sterilize. what's more the kits are sars-cov-2 only. once the test result is negative, it cannot help diagnose the exact pathogen in one time of experiment. therefore, this project intends to independently develop a fully enclosed rapid detection system for a total of 22 pathogens, including sars-cov-2, on the basis of the qiastat-dx fully automatic multiple pcr detection platform. the reasonably designed experiments are used to verify the performance of the cartridge detection and prove its clinical application value. the 22 pathogens tested in this project includes 4 coronavirus subtypes, a / b flu, parainfluenza virus, respiratory syncytial virus, etc., which is of great significance for the differential diagnosis of similar patients.

Eligibility criteria:
inclusion criteria: * patients went to the fever clinic with respiratory infectious symptoms exclusion criteria: * none
impendia- pen vs dianeal only improved metabolic control in diabetic capd and apd patients

Conditions: ESRD; Diabetes

Summary: primary objective: to demonstrate that use of glucose sparing prescriptions (pen vs dianeal) in diabetic (type 1 and type 2) continuous ambulatory peritoneal dialysis (capd)and automated peritoneal dialysis (apd) patients leads to improved metabolic control as measured by the magnitude of change from the baseline value in the hba1c levels. secondary objectives: to demonstrate that use of glucose-sparing pd solutions (pen vs dianeal) in diabetic (type 1 and type 2) capd and apd patients leads to lower glycemic-control medication requirements, decreased incidence of severe hypoglycemic events requiring medical intervention, improved metabolic control, nutritional status, and quality of life. in a subgroup of patients, the impact of glucose-sparing pd solutions (pen vs dianeal only) on abdominal fat and left ventricular (lv) structure and function will be assessed.


Eligibility criteria:
inclusion criteria: 1. m/f patients 18 years of age or older 2. diagnosis of esrd (gfr ≤ 15 ml/min) 3. capd or apd using only dianeal and/or physioneal, at least 1 exchange of 2.5% or 4.25% dextrose/day, no prescribed dry time 4. dm (type 1 and 2) on glycemic-control medication, for 90 days 5. hba1c \> 6.0% but ≤ 12.0% 6. blood hemoglobin ≥ 8.0 g/dl, but ≤ 13.0 g/dl exclusion criteria: 1. cardiovascular event within the last 90 days 2. ongoing clinically significant congestive heart failure (nyha class iii or iv) 3. allergy to starch-based polymers 4. glycogen storage disease 5. glycogen storage disease 6. peritonitis, exit-site or tunnel infection treated with antibiotics within last 30 days 7. mean arterial pressure (map) ≥ 125 mm hg, or volume depleted (map \< 77) at screening. 8. serum urea \> 30 mmol/l 9. receiving rosiglitazone maleate

Keywords: esrd diabetes capd apd
sedation during muscle biopsy in patients with duchenne muscular dystrophy

Conditions: Duchenne Muscular Dystrophy

Summary: this is an interventional study on duchenne muscular dystrophy patients who will be receiving sedation for a muscle biopsy as part of another study.


Eligibility criteria:
inclusion criteria: * patients undergoing a muscle biopsy for irb11-00203.