Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of 3 different dosage regimens of hyaluronic acid in patients with knee osteoarthritis (oa)

Conditions: Osteoarthritis of the Knee

Summary: the main objective is the comparison of three different dosage regimens of hyaluronic acid in the treatment of osteoarthritis of the knee.


Eligibility criteria:
inclusion criteria: * outpatient\>45 years of age diagnosed with primary osteoarthritis according to acr and kellgren criteria * knee pain ≥ 55 mm and ≤90 mm measured by visual analogue scale (vas) 100 mm * ability to understand and follow study procedures * written informed consent exclusion criteria: * patients with secondary osteoarthritis of the knee according to acr criteria. * severe inflammation of the knee diagnosed by physical examination or a sedimentation speed rate \< 40 mm/h and serum rheumatoid factor titre \< 1:40 * patients having previously received surgery, including arthroscopy * patients with joint inflammatory disease (spondilitis, systemic rheumatoid arthritis), microcrystalline arthropathies (chondrocalcinosis, gout, fibromyalgia) and significant osteoarthritis symptoms in other joints apart from the knee, and which require pharmacological treatment * previous administration of any of the following treatments: hyaluronic acid ia (last year); steroids i.a. or joint lavage (last 3 months), glucosamine sulfate, chondroitin sulfate or diacerein (last 3 months), nsaids (last 14 days), any investigational drug (last month) or its administration during this study
educational intervention for the promotion of knowledge and preventive health behaviors related to personal air pollution exposure, the air study

Conditions: Lung Carcinoma

Summary: this clinical trial will conduct an educational intervention to promote knowledge of and preventive health behaviors related to personal air pollution exposure. air pollution is n ubiquitous environmental exposure that is associated with harmful health effects including lung cancer. the educational intervention is comprised of 2 educational videos that include information regarding air pollution, health effects, and personal preventive health behaviors to reduce air pollution exposure and the use of a wearable air pollution sensor. the knowledge gained from this study may inform future research that will be designed to promote awareness of air pollution and its health effects.

outline: participants watch 2 educational videos during week 3 regarding air pollution, health effects, and personal preventive health behaviors to reduce air pollution exposure. participants complete questionnaires at weeks 1 and 5.

Eligibility criteria:
inclusion criteria: * adults 18 years or older: the evidence for personal strategies to reduce air pollution exposure has been focused on adults * live in seattle, wa: the study is designed to focus on seattle, wa such as using enviroflash alerts * own a smartphone: the participant requires a smartphone to setup the flow app for the air pollution sensor * not traveling in the near-term: the study is designed to assess air pollution patterns in the local seattle area * leave your home for at least 7 hours per week: participants will use a wearable air pollution sensor to measure air pollutant levels from indoor and outdoor sources
baldachin: ceiling hepa-filtration to prevent nosocomial transmission of covid-19

Conditions: COVID-19

Summary: in this study, a patient space occupied by a patient with confirmed covid-19 in an open-space multiple bed area in the intermediate care unit will be equipped with a mobile, optimally placed high efficiency particulate air ("hepa")-equivalent air filtration unit ("baldachin") in addition to existing hospital policy infection prevention and control measures. the investigators are going to evaluate this intervention regarding its capacity to prevent the nosocomial onwards transmission of sars-cov2 to patients located in the same multiple-bed open space patient area.

sars-cov-2 transmission includes a considerable amount of long-distance aerosol transmission. ideal isolation is in single rooms. isolation in special care multiple bed open-space patient areas (e.g. in the intensive and intermediate care unit) is set back to onsite isolation with distancing and ventilation as partial mitigation measures against nosocomial transmission. the investigators want to assess the effect of supplementation of existing room ventilation by means of an optimally placed mobile high efficiency particulate air ("hepa") filtration unit ("baldachin") in the ceiling area over confirmed covid-19 infected patients on nosocomial onwards transmission to patients located in the same open-space multiple bed area. in order to quantify the effect, the investigators will determine the proportion of nosocomially infected individuals as assessed by nasopharyngeal swab on day 4 after the last exposure amongst all in the same room exposed patients in cardiovascular open-space intermediate care unit rooms with "baldachin" vs. open-space intermediate care unit rooms without "baldachin".

Eligibility criteria:
inclusion criteria: * adult inpatients of included open-space imc units with lab-confirmed sars-cov-2 infection, symptom onset or date of test ≤10 days prior inclusion. exclusion criteria: * pregnancy, unability to give consent (e.g. informed consent form not available in patient language or non-judicious)

Keywords: sars-cov2 aerosols infection transmission infection risk respiratory tract infections virus diseases
dbs of the mlr for gait and balance disorders in pd patients

Conditions: Parkinson's Disease

Summary: gait and balance disorders represent the main motor disability in advanced parkinson's disease. these symptoms are less or unresponsive to levodopa treatment and are considered to be a contraindication for deep brain stimulation of the subthalamic nucleus. falls and freezing of gait are responsible for high morbidity (fractures, residential health care) and increased significantly mortality. the pathophysiology of gait and balance disorders is still poorly understood, but recent data obtained in animals and humans suggest that a degeneration of cholinergic neurons of the pedunculopontine nucleus (ppn), within the mesencephalic locomotor region, could play a crucial role. in line with this hypothesis, low-frequency stimulation of the pedunculopontine area, thought to increase the activity of the remaining cholinergic ppn neurons, has been proposed to alleviate gait and balance disorders in advanced pd patients. here, the efficacy of deep brain stimulation of the mesencephalic locomotor region will be tested in 12 pd patients in a randomized, double-blind, cross-over, controlled study.


Eligibility criteria:
inclusion criteria: * age below 71 years * severe form of parkinson's disease with disease duration \> 5 years * presence of gait and/or balance disorders unresponsive to levodopa treatment, * \> 40% decrease in others motor symptoms with levodopa treatment * health insurance * give signed informed written consent exclusion criteria: * dementia (mattis dementia rating scale \< 129, mdrs), * ongoing psychiatric disturbances, * surgical contraindications * significant brain lesions detected on mri.

Keywords: parkinson's disease deep brain stimulation mesencephalic locomotor region
associations analysis between lifestyle and osteoporosis

Conditions: Osteoporosis of Disuse With Current Pathological Fracture

Summary: a large-scale, community-based, cross-sectional study was conducted to evaluate the extent to which lifestyle was associated with osteoporosis among the chinese population by using self-reported questionnaire methods.

a large-scale, community-based, cross-sectional study was conducted to evaluate the extent to which lifestyle was associated with osteoporosis among the chinese population by using self-reported questionnaire methods. more than 3000 participants were recruited in communities in shanghai. data involved in demographic information, lifestyle, dietary habits, medical history and clinical biomarkers were collected. every participants were measured bone mineral density (bmd g/cm2) at calcaneus by standardized quantitative ultrasound (qus, hologic inc., bedford, ma, usa) utilizing t-scores based on who criteria. a standard statistical analysis including univariate and multiple variables regression analysis to explore the risk or preventive factors involved in chinese lifestyle associated with osteoporosis.

Eligibility criteria:
inclusion criteria: * participants aged 30-90 years were recruited from rural and urban communities in shanghai. exclusion criteria: * some participants with chronic diseases and conditions that might potentially affect bone mass, structure, or metabolism were excluded. briefly, the exclusion criteria were as follows: a history of 1. serious residual effects of cerebral vascular disease; 2. serious chronic renal disease (glomerular filtration rate - gfr \< 30 ml/min/1.73m2); 3. serious chronic liver disease or alcoholism; 4. significant chronic lung disease; 5. corticosteroid therapy at pharmacologic levels; 6. evidence of other metabolic or inherited bone disease, such as hyper- or hypoparathyroidism, paget disease, osteomalacia, or osteogenesis imperfecta; 7. recent (within the past year) major gastrointestinal disease, such as peptic ulcer, malabsorption, chronic ulcerative colitis, regional enteritis, or significant chronic diarrhea; 8. cushing syndrome; 9. hyperthyroidism; and 10. any neurologic or musculoskeletal condition that would be a non-genetic cause of low bone mass.
foresee home for monitoring age related macular degeneration (amd)

Conditions: Age Related Macular Degeneration

Summary: the foresee home is intended for the early detection of central and paracentral irregularities (abnormalities) in the visual field, most commonly associated with amd. however, the device has ability to detect the development of the lesion post treatment and therefore to asses in determination of the next treatment.

the foresee home is intended for the early detection of central and paracentral irregularities (abnormalities) in the visual field, most commonly associated with amd. however, the device has ability to detect the development of the lesion post treatment and therefore to asses in determination of the next treatment. the oct may be use as well to identify choroidal neovascularization (cnv). comparison between the two methods will allow better understanding of both devices. the foresee home can use as an assessment tool for the progression and success of the treatment given to amd lesions. therefore, evaluation the size and the location of the treated lesions may serve as an additional tool.

Eligibility criteria:
inclusion criteria: * capable and willing to sign a consent form and participate in the study * subjects diagnosed as cnv under treatment or intermediate amd in at least one eye * did not perform more then 10 anti- vegf injections * age \>50 years * va with habitual correction \>6/45 in the study eye * computer users exclusion criteria: * evidence of macular disease other than amd or glaucoma in the study eye * presence of any significant media opacity that precludes a clear view of the macular area as identified in the study eye by biomicroscopy, * any non-macular related ocular surgery performed within 3 months prior to study entry in the target eye

Keywords: amd, cnv
clinical outcomes, nutritional status, exercise and psychosocial factors in pediatric hematopoietic cell transplant

Conditions: Malnutrition; Obesity

Summary: children who receive hematopoietic cell transplants (hct) are at high nutritional risk due to comorbidities and complications that are likely to develop before, during and after transplant. prior to transplant, many children undergo multiple rounds of chemotherapy which affect appetite and cause gastrointestinal toxicities that limit food intake. during transplant, painful mucositis makes it difficult to consume adequate nutrients and often children will require nutrition support such as parenteral or enteral nutrition. energy imbalance and physical deconditioning following transplant can result in loss of lean body mass and functional impairment; these nutritional side effects are exacerbated if the child develops graft-versus-host disease. after transplant, a substantial number of childhood cancer survivors become overweight and develop metabolic syndrome. however, little is known about the prevalence and distribution of pediatric malnutrition (under-nutrition as well as obesity), the psychosocial factors that affect dietary intake and how the quality of the child's food intake and physical activity level throughout the transplant process might affect body composition and clinical outcomes. in this exploratory study, we will monitor nutritional status in pediatric patients undergoing hct. this study will test the feasibility of collecting patient-reported dietary intake data along with anthropometric, body composition, functional status and psychosocial measurements that may influence dietary intake in pediatric patients undergoing hct. the data collected in this preliminary analysis will inform future interventional studies.


Eligibility criteria:
inclusion criteria: * pediatric hematopoietic cell transplant patients, aged 2-25 years. * participants and/or at least one caregiver must speak, read and understand english. exclusion criteria: * children younger than 2 years old at the time of their transplant or any child who is still breastfeeding will not be eligible due to the nature of the questionnaires and measurements.
efficacy of two antiemetic regimens in patients receiving radiotherapy and concomitant weekly cisplatin

Conditions: Nausea; Vomiting; Genital Neoplasms, Female

Summary: gand-emesis is a multinational, randomized, double-blind, placebo-controlled, parallel-group study to investigate the efficacy and tolerability of a neurokinin1 receptor antagonist (fosaprepitant dimeglumine) in combination with an antiemetic (anti-nausea-and-vomiting) control regimen (palonosetron and dexamethasone) in patients with a gynaecological cancer diagnosis, who are scheduled to receive radiotherapy and weekly chemotherapy. the study aims at investigating if a three-drug antiemetic regimen is superior to a two-drug regimen (standard treatment) in preventing nausea and vomiting in patients receiving radiotherapy and weekly chemotherapy. a pilot study demonstrated that approximately 50% of patients will experience nausea and vomiting when offered a two-drug antiemetic regimen, and it is expected that addition of a third drug (a neurokinin1 receptor antagonist) can increase the proportion of patients with no vomiting in the course of combined chemo-radiotherapy.


Eligibility criteria:
inclusion criteria: (abbreviated) 1. the patient has a diagnosis cervical cancer. 2. the patient understands the nature and purpose of this study and the study procedures and has signed informed consent. 3. the patient is aged \> 18 years. 4. the patient must be both chemo- and radiotherapy (rt) naïve. nb: previously low voltage rt or electron rt for non-melanoma skin cancers is allowed. 5. the patient is scheduled to receive fractionated radiotherapy and concomitant weekly cisplatin at a dose of ≥ 40 mg/m2 for at least five weeks. 6. brachy therapy is scheduled to be initiated after the third cycle of weekly cisplatin, and preferentially after the fifth week of treatment. 7. chemotherapy with an emetic risk potential of minimal or mild (up to 30%) is allowed on days 1-4 (see ref. 14). 8. the patient has a who performance status of ≤ 2. exclusion criteria: (abbreviated) 1. the patient has a current malignant diagnosis other than cervical cancer, with exception of non-melanoma skin cancers. 2. the patient is aged \< 18 years. 3. the patient is scheduled to receive less than five weeks of fractionated radiotherapy and concomitant weekly cisplatin. 4. brachy therapy is planned to be initiated before the third cycle of weekly cisplatin. 5. the patient has been previously treated with radiotherapy, and/or chemotherapy, with exception of treatment with low voltage rt or electron rt for non-melanoma skin cancers . 6. the patient has a who performance status of \> 2.

Keywords: randomized controlled trial serotonin agonists dexamethasone receptors, neurokinin-1 radiotherapy cisplatin prevention & control
effects of home-based exercise in parkinson's disease

Conditions: Parkinson Disease

Summary: home-based exercise program focusing on axial rigidity could be used as an adjunct rehabilitation program to improve rotational movement, gait and functional movement associated with axial rigidity in individuals with pd.

typically, individuals with pd revert to more primitive movement patterns, which lack many of the automatic postural adjustments and axial movements that accompany simple activities, such as supine to standing, getting up from sitting or turning over in bed. the present study is designed to allow patients and their relatives to perform exercises by themselves conveniently at home. the results were considered a vital component of a complex intervention and were played an integral part in the implementation process of exercises in functional performance. furthermore, this study will prove sufficient high-quality evidence to investigate whether improvements in function due to exercise-based rehabilitation are associated with reducing axial rigidity in individuals with pd. currently, there is a lack of evidence for the effectiveness of home-based exercise programs in pd patients in thailand. for the present study, we devised a home-based 10-week exercise program focusing on segmental rotation and task-specific movements for turning practice to determine effects on axial mobility and turning. the aimed of this study to examine the effects of a 10-week task specific home-based exercise program on turning kinematics, gait and stepping characteristics, the functional reach test (frt), the unified parkinson's disease rating scale (updrs), the freezing of gait questionnaire (fog) and the fall efficacy scale international (fes-i) in individuals with pd.

Eligibility criteria:
1. inclusion criteria; * clinically diagnosed with pd stages 1.5 to 3 as assessed by the modified hoehn and yahr scale * the age groups between 50 and 75 years * taking pd medication regularly for at least a month * no signs of wearing-off phenomenon * able to walk independently without any assistive device and 6) able to follow commands and instructions 2. exclusion criteria; * clinically diagnosed with dementia or other neurological or cardiopulmonary diseases * musculoskeletal problems that could influence the test performance such as arthritis or severe leg pain * high blood pressure (more than 140/90 mmhg) * haemodialysis * visual problems that could not be adjusted with lenses or glasses * taking medicine which affected to functional movement.

Keywords: exercise gait characteristics
effects of clinical pilates and whole body vibration exercises in postmenopausal osteoporotic women

Conditions: Osteoporosis

Summary: the aim is to compare the effects of clinical pilates and whole body vibration exercises in postmenopausal osteoporotic women on strength, flexibility, balance, bone turnover markers and quality of life.

the aim of this study is to compare the effects of clinical pilates and whole body vibration exercises in postmenopausal osteoporotic women in terms of strength, flexibility, balance, bone turnover markers and quality of life. thirty-four women who are diagnosed with postmenopausal osteoporosis will be recruited into the study. participants will be divided into two groups: (1) clinical pilates group, (2) vibration exercises group. exercise programs will be performed two times per week for twelve weeks. the strength of the extensor muscles of the hip, knee, back, elbow will be measured with a hand-held dynamometer. flexibility will be assessed measuring the fingertip-to-floor distance in flexion and lateral bending. the balance performance will be assessed using the timed up and go test, tetrax fall index and the maximum hold time on unipedal stance and on tandem stance. the short form-12 questionnaire will be used to assess the quality of life. also, bone turnover markers will be measured. all assessments will be performed before and after exercise programs.

Eligibility criteria:
inclusion criteria: * being in the postmenopausal period * having body mass index equal to or greater than 18,5 kg/m² * a lack of regular exercise * having been diagnosed with osteoporosis * having the ability to walk independently exclusion criteria: * having a cardiopulmonary problem that may prevent participating in exercise programs * having kidney stones * being diagnosed with diabetes * presence of epilepsy * having cardiological problems such as arrhythmia, using a pacemaker, hypertension * having neurological disorders such as parkinson, stroke, multiple sclerosis, neuropathy * having surgery in the last 6 months

Keywords: postmenopausal osteoporosis clinical pilates whole body vibration bone turnover markers strength flexibility balance quality of life