Kornimate/medical-research-clean huggingface dataset:
broad effectiveness: study with aripiprazole

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: the purpose of this study is to learn if aripiprazole is effective in the treatment of a large number of persons diagnosed with schizophrenia or schizoaffective disorders


Eligibility criteria:
* patients with schizophrenia or schizoaffective disorder
effect of intranasal insulin on pocd and pod

Conditions: Delirium; Heart Diseases

Summary: decline in cognitive function after surgery occurs most commonly in older patients and patients undergoing major surgeries, such as heart surgery. postoperative cognitive dysfunction (pocd) may last a prolonged period of time while postoperative delirium (pod) is a more acute disturbance in attention, awareness and cognition. the cause of pocd and pod are not fully understood, however some of the pathophysiology of pocd is similar to that of alzheimer's disease (ad). insulin given intravenously during heart surgery has been shown to preserve short and long-term memory function after the operation. clinical trials further demonstrated that insulin given via the nose (intranasal) improves memory performance of patients with ad or cognitive impairment suggests that intranasal insulin also could be a therapeutic option for pocd and pod. this study is designed to examine the effect intranasal insulin on pocd and pod. the goal is to investigate whether administration of intranasal insulin during and after heart surgery improves cognitive function postoperatively.


Eligibility criteria:
inclusion criteria: •elective open heart surgery requiring cardiopulmonary bypass exclusion criteria: * inability to provide informed consent * allergy to insulin * pregnancy * mother tongue other than english or french * visual or hearing impairment interfering with the ability to complete cognitive tests.
transitions between clinical circulatory states after out-of-hospital cardiac arrest

Conditions: Out-of-Hospital Cardiac Arrest

Summary: extensive research exists for cardio-pulmonary resuscitation (cpr) and the chance of successful return of spontaneous circulation (rosc) is improved. unfortunately, the overall prognosis after rosc has not improved much and the in-hospital mortality is still reported to be 50 to 70 %. the "post-resuscitation disease" is now called the "post-cardiac arrest syndrome" (pcas) and comprises 1) brain injury, 2) myocardial dysfunction and 3) systemic ischemia and reperfusion. treatment of patients after cardiac arrest has often followed guidelines that were primarily developed for treatment of septic shock. it is still uncertain whether this is the optimal way to deliver circulatory support after cardiac arrest. there is a lack of studies assessing the relationship between the inflammatory response measured by inflammatory biomarkers and circulatory failure in pcas. in this study a detailed description will be given of the clinical trajectory of the circulation and the inflammatory response during the first 5 days after cardiac arrest, and it will be investigated whether patterns of circulatory and inflammatory response may be predictive of deterioration of clinical state.

this study will obtain longitudinally advanced hemodynamic observations with high resolution during the acute phase of post cardiac arrest syndrome (pcas), and analyze the details in clinical transitions related to circulatory failure. the study will also analyze the relationship between inflammatory biomarkers and circulatory failure in pcas and kinetics of hemodynamics associated with standard interventions in the intensive care unit (icu).

Eligibility criteria:
inclusion criteria: * return of spontaneous circulation (rosc) after out-of-hospital cardiac arrest (ohca) * admitted to coronary care unit (ccu) or intensive care unit (icu), st. olav's university hospital exclusion criteria: * sepsis within 24 hours before cardiac arrest * pregnancy * decision of withdrawal or withholding of life prolonging therapy (i.e. due to advanced malignancy)

Keywords: blood circulation follow-up studies biological markers hemodynamics
factors associated with decisions to withhold or withdraw intensive care

Conditions: Sepsis; ARDS, Human; COVID-19

Summary: medical and socioeconomic data are extracted from the swedish intensive care registry (sir), the swedish national patient registry and statistics sweden for all adult patients admitted to in swedish intensive care units between 2014-01-01 and 2020-12-31 with a diagnosis of sepsis and/or acute respiratory distress syndrome (ards) and/or coronavirus 19 (covid-19) infection, and registered in sir. the impact of demographic and socioeconomic factors on decisions to withhold or withdraw intensive care, and on mortality, are studied and statistically adjusted for level of chronic comorbidity and severity of acute illness.

patient identification and data acquisition with permission from the ethical board of sweden, all registered intensive care episodes with a diagnosis of sepsis, acute respiratory distress syndrome (ards) or coronavirus 19 (covid-19) and admission between 2014-01-01 and 2020-12-31 are identified in the swedish intensive care registry (sir). basic demographic data (age, sex) and intensive care data from sir are combined with comorbidity data from the national patient registry of the board of health and welfare (socialstyrelsen), and data on country of birth, household size, education and economy from statistics sweden (scb) to produce a pseudonymized study data set. for patients with multiple intensive care episodes, the first one is used. analysis descriptive data on the frequency of decisions to withhold or withdraw intensive care, and on demographic and socioeconomic factors, morbidity and mortality in patients with or without such decisions, are produced. logistic regression is used to assess the association between demographic and socioeconomic factors and limitations in intensive care, adjusting for acute and chronic morbidity and accounting for multicenter data. secondarily, association between the same factors and mortality is studied.

Eligibility criteria:
inclusion criteria: * registered intensive care episode with relevant diagnosis exclusion criteria: * none, if inclusion criteria fulfilled

Keywords: critical care limitations of care critical illness intensive care unit
perioperative morbidity in adult scoliotic surgery: analysis of a series from brest (mosca-b)

Conditions: Adult Scoliosis; Spine Deformity; Neurosurgery

Summary: scoliosis surgery is an invasive procedure essential for alleviating significant pain and improving the physical, psychological, aesthetic, professional, and social well-being of patients. however, it carries a considerable risk of perioperative complications. this retrospective study, conducted at brest university hospital since 2017, aims to analyze these complications to provide a detailed assessment, particularly since the introduction of the oarm (intraoperative ct navigation), with the goal of optimizing the safety and effectiveness of surgical interventions. the complications studied include neurological, infectious, mechanical, and cardiopulmonary complications, along with an additional "other" category for rare complications. the period analyzed extends from the immediate postoperative phase to the most recent follow-up consultation with the referring surgeon, which varies depending on the duration of follow-up for each patient.


Eligibility criteria:
inclusion criteria: * adult patient * patient affiliated with a social security system * who underwent scoliosis surgery between 2017 and 2024 at the brest university hospital exclusion criteria: patients under legal protection (guardianship, curatorship, etc.) refusal to participate (expressed opposition) history of scoliosis surgery performed by another surgeon, regardless of the center or year

Keywords: adult scoliosis spine deformity neurosurgery spine surgery
predictors of functional remission in discharged patients with schizophrenia after long-term drug discontinuation

Conditions: Schizophrenia

Summary: study objectives: 1. describe the characteristics of discharged patients with schizophrenia achieving functional remission after drug discontinuation. 2. establish a prediction model of patients with schizophrenia having good prognosis after drug discontinuation.

there are 2 clinically important and urgent questions to be explored in this study: 1. who is more likely to benefit from guided drug reduction or discontinuation? how to design an individualized treatment plan which can balance the risk of relapse and side-effects from antipsychotics? 2. what are the predictors of functional remission in patients with schizophrenia after drug discontinuation? this will be the first related study to be conducted in china.

Eligibility criteria:
inclusion criteria: * patients who met the diagnostic criteria of the international classification of diseases, 10th edition (icd-10) for a diagnosis of schizophrenia; * aged between 18 to 65 years old at time of investigation; * hospitalized in shanghai mental health center any time from the year 2013 to 2018; * informed consent. exclusion criteria: * patients with neurological diseases, severe somatic diseases, psychoactive substance abuse, mental retardation, agitation, stupor, or risk of suicide, and female patients who are pregnant or breast-feeding, will be excluded from the study.
the effects of yoga in mental health professional helpers

Conditions: Occupation-related Stress Disorder

Summary: this study will investigate if yoga exercises decrease work-related stress and improve stress adaptation in professional health helpers.

mental health professional helpers including psychiatrists, nurses, psychologists, social workers and occupational therapists often call upon to maintain a good working attitude and enthusiasm, especially in the face of the evaluators of credential systems as well as supervisors' authorities. the symptoms of work-related stress of professional helpers developed day by days and affected their physical and mental health. gradually, the professional helpers burned out. philip burnard (1991) mentioned professional helpers might self-neglect while helping others. these would lead to over work related stress that directly affects the physical and mental health of the professional helpers, and indirectly affects the organization to take care of the patients and their families. according to researchers and personal experience, colleagues of mental health care developed work-related stress symptoms, such as insomnia or sleep disorder, the physiological disorders, weight fluctuations, irritable or depressed while taking care of psychiatric patients. they might take tranquilizers in order to maintain the quality of work. on the other hand, in april 2012, the researchers engaged in yoga teaching, assisting mental health care to help others of engaging in yoga practice showed that members perceived positive feelings after the yoga practice: "the mood is more relaxed," "tight body become more relaxed and soft resulting in awareness of tension and unease. this helps to modify long-term adverse stances and reduce body aches and/or sitting." for this reason, researchers began to apply yoga to the release work-related stress and enhance stress adaptation. professional health helpers look forward to practice yoga exercises to relax work-related stress and improve stress adaptation. it is a parallel-arm randomized control trial compare the outcome of participants assign to the experimental treatment group (yoga, with 30 participants) with those assign to a control group for 3 months (12 weeks). experimental group receive regular 60-minutes yoga classes twice a week. we confer the difference of work-related stress relief and stress adaptation and biofeedback improvement after yoga.

Eligibility criteria:
inclusion criteria: * mental health professional helpers. * without sport training. * age 20\~60. exclusion criteria: * musculoskeletal injury.

Keywords: yoga work-related stress, stress adaptation.
a study to investigate the safety and clinical effect of nexagon® to treat persistent epithelial defects

Conditions: Persistent Epithelial Defect

Summary: the purpose of this study is to evaluate the efficacy and safety of nexagon® in subjects with persistent epithelial defects (ped) originally caused by chemical burns.


Eligibility criteria:
inclusion criteria: 1. male and female subjects aged 18 years and over. 2. subjects who are able to attend all follow-up visits and who are able to comply with all study procedures. 3. subjects who are willing and able to give written informed consent to take part in the study. 4. at the day -7 visit subjects must have a corneal epithelial defect that has persisted for between 7 days and 14 days, which has a minimum diameter of 2 mm along the greatest axis, and which has not shown improvement despite conventional treatment such as tear supplements and bandage contact lenses. 5. the original defect to the cornea must have been caused by either alkaline or acidic agents. exclusion criteria: 1. use of concomitant ocular medications in the screening period that are not specified in standardized ped treatment regime 2. likely to require the use of concomitant ocular medications that are not specified in the standardized ped treatment regime during the study follow-up period 3. decrease or increase in the ped by more than 30% during the screening period. 4. have an active lid or ocular infectious process of any sort 5. subjects with corneal perforation or impending corneal perforation 6. the circumference affected by limbal blood vessel ischemia is greater than 75% of the circumference 7. subjects with severe lid abnormalities contributory to the persistence of the ped such as inability to close the lids. 8. subjects with bilateral ped, if the smaller ped has a longest diameter of \> 2 mm. 9. female subjects who are pregnant or breastfeeding. f 10. subjects who have a history of aids or hiv. 11. subjects with any other condition which, in the investigator's opinion, would exclude the subject from participating. 12. treatment with systemic corticosteroids (equivalent to \> 10 mg/day of prednisone) or immunosuppressive or chemotherapeutic agents within 7 days prior to day 0, or likely to receive one of these therapies during study participation 13. subjects who have participated in a clinical trial within 30 days prior to day 0. 14. diabetics with an hba1c greater than 6.5%. 15. diabetics who are currently prescribed more than one oral medication for their diabetes. 16. subjects who have more than one distinct ped in the study eye.

Keywords: persistent cornea defect nexagon coda
a study of participants with non-valvular atrial fibrillation (nvaf) treated or untreated with oral anticoagulant in the national cerebral and cardiovascular center (ncvc) in japan

Conditions: Non-Valvular Atrial Fibrillation (NVAF)

Summary: the purpose of this observational study is to understand real-world oral anticoagulants (oac) (warfarin, apixaban, dabigatran, edoxaban and rivaroxaban) usage for non-valvular atrial fibrillation (nvaf) patients.


Eligibility criteria:
inclusion criteria: • participants received medical treatment for nvaf between 10-jan-2012 and 31-aug-2020. exclusion criteria: * had no data of serum creatinine in the participant's medical records * had no data of body weight in the participant's medical records * were given oral anticoagulant (oac) for treatment of diseases other than atrial fibrillation (af) other protocol-defined inclusion/exclusion criteria apply.

Keywords: bms-562247 apixaban atrial fibrillation oral anticoagulants japan retrospective study
resistance training during maintenance dialysis

Conditions: End Stage Renal Disease

Summary: there is a rising incidence of kidney failure in the us, with poor outcomes and high cost. end-stage renal disease (esrd) affects almost 375,000 individuals in the us at a cost of more than $14 billion per year. despite advances in dialysis and transplantation therapies, kidney failure leads to poor outcomes, poor prognosis and high health care costs. malnutrition and the underlying systemic inflammatory response developed during the course of chronic kidney disease, worsen during esrd, and lead to adverse outcomes, increased morbidity and mortality. muscle wasting, impaired functional capacity and poor quality of life are the most important factors associated with malnutrition and inflammation in renal failure. we have shown in pre dialysis patients with moderate chronic renal insufficiency that the anabolic effects of resistance exercise training result in significant improvements in protein utilization, nutritional status and functional capacity even in the context of anorexia and prescribed low protein diets. therefore, we propose to develop, test and implement a progressive resistance exercise routine for esrd patients during the hemodialysis session. by implementing such intervention, we hope to offer a therapeutic strategy that can be incorporated to the standard of care of esrd patients by working in conjunction with the dialysis unit staff.

the hypotheses to be investigated are that, compared to esrd patients on maintenance dialysis receiving stretches only, the addition of 30-45 min of progressive resistance training during the hemodialysis session will counteract the burden of renal disease and will result in: 1. a feasible and safe exercise modality for esrd patients. 2. will contribute to improved nutritional status and reduced systemic inflammation 3. will result in improved quality of life

Eligibility criteria:
inclusion criteria: * male and female esrd patients over 30 years of age * esrd patients undergoing maintenance hemodialysis 3x/wk for at least 3 months * willing to be randomized to either study group * compliance with at least 80% of the dialysis sessions exclusion criteria: * unstable cardiovascular disease * any uncontrolled chronic condition * cardiac surgery, myocardial infarction, joint replacement, or low extremity fracture within the previous 6 months * severe cognitive impairment resulting in inability to understand and provide written informed consent form and or follow instructions * current resistance training * low extremity amputees

Keywords: end stage renal disease maintenance dialysis resistance exercise muscle wasting disability
proportional open ventilation (pov) device and its efficacy in managing acute respiratory failure in covid-19 patients

Conditions: Acute Respiratory Failure; Covid19

Summary: to evaluate the use of life2000® ventilator, a novel proportional open ventilation system in critical care use of acute onset of respiratory failure (arf) and mild to moderate forms of acute respiratory distress syndrome (ards) in covid-19 patients and its ability to provide effective ventilatory benefits and or delay patients from progressing to more aggressive forms of invasive mechanical ventilation (imv).


Eligibility criteria:
inclusion criteria: patients who meet all of the following inclusion criteria and no exclusion criteria will be included in the study: * a diagnosed or suspected covid-19 patient requiring non-invasive ventilatory support and admitted to hospital * pao2/fio2 ≤ 300 (corrected for altitude) * rr ≤ 30/min during early use of oxygen * adults of 18 years and older * provision of written informed consent to participate in study by subject or legal representative. exclusion criteria: patients who meet one or more of the following exclusion criteria will not be eligible for the study: * patients under the age of 18 * patients who are not diagnosed or suspected of having an acute covid-19 illness * patients who do not require non-invasive ventilatory interventions, pao2/fio2 \> 300 (corrected for altitude) and tolerating supplemental oxygen with spo2 saturations ≥ 92%. * patients who require immediate imv upon admission or have a rr \> 30/min on early oxygen intervention. * thoracoabdominal desynchrony and paradoxical breathing at admission * patients in immediate need of or on vasopressors upon icu admission * patients or legal representatives who are unwilling or unable to provide written consent.

Keywords: ards peep respiratory rate
response of vegf and at-ii to hcg in pcos

Conditions: Polycystic Ovary Syndrome

Summary: this research is to investigate the response of vascular active factors, vascular endothelial growth factor (vegf) and angiotensin-ⅱ (at-ⅱ) to ovary stimulation during 24h in patients with polycystic ovary syndrome (pcos).controled prospective clinical study involved 60 women undergoing in vitro fertilization. fifty-two patients with pcos and 8 control cases were stimulated with human chorionic gonadotropin (hcg) during the early follicular phase of the menstrual cycle (4st to 7th days of the cycle).the blood was sampled before the injection (0 hour) and at the 3, 6, 12, 18 and 24 hours points after the stimulation. vegf, at-ⅱ were measured by radioimmunoassay.

after ovary stimulation, the level of vegf in typical pcos patients is obviously increased at the 3hs time point (p\<0.05), while there is no difference with vegf at all other time point among the four groups. as for at-ⅱ, before and after the ovary stimulation, at all time points, the at-ⅱ levels in serum of patients with different phenotypes of pcos by rotterdam criteria are all higher than the controls without pcos. after the ovary stimulation, at-ⅱ in typical pcos patients is obviously increased at 3hs time point, p\<0.05. the response of vegf and at-ⅱ to hcg in women with typical pcos is higher in 24 hours after the stimulation during the early follicular phase. the response to the stimulation is different in patients with different phenotypes of pcos by rotterdam criteria. serum vegf and at-ⅱ levels as a possible contributor to a great risk of developing ohss in patients with typical pcos during the early follicular phase in 24 hours after the ovary stimulation.

Eligibility criteria:
inclusion criteria: * a total of 60 women were recruited and divided into four groups by rotterdam criteria according to three typical characters: 1. biochemical characteristics of hyperandrogenism (ha) 2. chronic anovulation 3. polycystic ovary morphology (pco). exclusion criteria: * all women were matched for age (\<35 yr). * all subjects were screened, and no other endocrine disturbances (thyroid, adrenal) or medical illnesses were found. * all the patients did not have any hormonal preparation during the 3 months preceding the study.

Keywords: polycystic ovary syndrome; vascular endothelial growth factor; angiotensin-ⅱ; ovarian hyperstimulation syndrome
reduced mbf regimen for patients >=55 years with myeloid malignancies

Conditions: Disease-free Survival

Summary: in this multiple-center phase ii study, the aim is to evaluate the clinical outcome of reduced intensity conditioning regimen with fludarabine (150mg/m2), busulfan (6.4mg/kg) and melphalan (100mg/m2) in patients with myeloid malignancies including aml, mds and cmml \>=55 years.

conditioning regimen with double alkylating agents such as busulfan + melphalan or busulfan + thiotepa have been shown to improve the transplantation outcome in terms of lower relapse rate in various myeloid malignancies. in this multiple-center phase ii study, the aim is to evaluate the clinical outcome of reduced intensity conditioning regimen with fludarabine (150mg/m2), busulfan (6.4mg/kg) and melphalan (100mg/m2) in patients with myeloid malignancies including aml, mds and cmml \>=55 years.

Eligibility criteria:
inclusion criteria: * age 55-65 * patients with hla-matched sibling donors, 9-10/10 matched unrelated donors or haplo-identical donors. * patients with aml in remission, or mds in any stage, or cmml in any stage * inform consent provided exclusion criteria: * patients with abnormal liver (\>3n), renal (1.5n) or cardiac function * patients with active infection