Kornimate/medical-research-clean huggingface dataset:
prolonged overnight fasting and/or exercise on fatigue and other patient reported outcomes in women with hormone receptor positive advanced breast cancer

Conditions: HER2-positive Breast Cancer; Advanced Breast Cancer

Summary: the purpose of this study is to test if four different programs (prolonged overnighting fasting alone, exercise alone, a combination of prolonged overnight fasting and exercise, or general health education sessions alone) can reduce fatigue in women with advanced or metastatic breast cancer who are receiving a medication called a cyclin-dependent kinases-4 and 6 (cdk4/6) inhibitor.


Eligibility criteria:
inclusion criteria: 1. women 2. able to provide written informed consent 3. able to read and understand english or spanish 4. postmenopausal (including concurrent use of ovarian suppression) 5. diagnosis of er+ and/or pr+, hormone estrogen receptor-2 (her-2)- metastatic or locally advanced unresectable breast cancer 6. initiating first-line or second-line endocrine therapy in combination with a cdk4/6 inhibitor (e.g. palbociclib, ribociclib or abemaciclib). participants can be enrolled up to 2 weeks after starting cdk4/6 inhibitor 7. having not consistently engaged in more than 90 minutes of moderate or 45 minutes of vigorous physical activity per week over the past 3 months 8. having not consistently engaged in resistance training 2 or more days per week over the past 3 months 9. having not consistently engaged in structured fasting (i.e., not regularly fasting for ≥12hr/night) for the past 3 months 10. approval from a medical oncology provider to participate. exclusion criteria: 1. unable to provide consent 2. unable to read or understand english or spanish 3. oxygen dependent 4. unstable cardiac disease 5. insulin-dependent diabetes 6. unable to walk 2 blocks without assistance (excluding canes) 7. unstable bone metastases 8. more than 15 days from initiation of first- or second-line endocrine therapy in combination with a cdk4/6 inhibitor
psu lumbar support for prevention of low back pain in rubber tapper

Conditions: Low Back Pain

Summary: this study aims to evaluate the efficacy of lumbar support for low back pain prevention in rubber tapper. the investigators will randomized the participants(rubber tapper) into 2 groups;lumbar support and no support.the participant will be instructed for brace use. the sample size required are 200 subjects with 100 in each group. the subject will be evaluated every 3 month for the incidence of low back pain and quality of life after using the support.


Eligibility criteria:
inclusion criteria: * current rubber tapper exclusion criteria: * underlying rheumatologic condition * previous significant low back pain * previous back surgery

Keywords: lumbar support rubber tapper
video-conferenced stress management and relaxation training (vsmart) for alabama breast cancer survivors

Conditions: Breast Cancer Early Stage Breast Cancer (Stage 1-3)

Summary: in a sample of alabama breast cancer survivors, the proposed study tests the feasibility and acceptability of a stress management program that has been shown to improve health and wellbeing in a general population of patients with a history of breast cancer. the study will also get feedback (e.g., implementation barriers and facilitators) from relevant stakeholders.


Eligibility criteria:
inclusion criteria: * breast cancer survivor * currently living in alabama * living in neighborhood with high deprivation index exclusion criteria: * non-alabama resident * no history of breast cancer * living in neighborhood with low deprivation index

Keywords: breast cancer
return to play criteria after shoulder dislocation in upper limb athletes: critical analysis between the habits of medical professionals and the literature

Conditions: Return to Sport; Survey and Questionnaire; Shoulder Dislocation

Summary: purpose: identify the criteria employed by sports medicine specialists in assessing the aptitude/inaptitude of an overhead athlete to return to competition following an antero-internal dislocation of the glenohumeral joint that has been operated or not. materials and methods: the target population consisted of french-speaking physicians in orthopedic surgery, physical medicine and rehabilitation or sports medicine. this study was conducted by the means of a questionnaire. the list of the most relevant criteria to be included in the questionnaire was established following a literature review.


Eligibility criteria:
inclusion criteria: * professions: physicians in orthopedic surgery, physical medicine and rehabilitation or sports medicine. * language: french exclusion criteria: * other professions
oral health related quality of life of patients with rare diseases: a qualitative approach

Conditions: Rare Diseases

Summary: the main objective of the study is to assess the oral health-related quality of life of patients with rare diseases and followed in the rare disease centers of expertise at necker hospital in paris by semi-structured interviews.

to date, few studies have used the qualitative method to analyze the oral health-related quality of life and the oral health care pathways of patients with rare diseases, all health sectors combined. the quantitative studies carried out using standardized questionnaires offer only a partial view of how patients feel, both children and adults. the main objective of the study is to assess the oral health-related quality of life of patients with rare diseases and followed in the rare disease centers of expertise at necker hospital in paris by means of a semi-structured interview.

Eligibility criteria:
inclusion criteria: * minor and adult patients with rare diseases aged of at least 6 years old and followed at the necker enfant malades hospital, paris * patients with the 3 most frequent rare diseases of each rare disease necker reference center participating in the study (10 centers : chronic and malformative disorders of the esophagus / inflammatory diseases of the bile ducts and autoimmune hepatitis / constitutional bone diseases / inherited metabolic diseases / biliary atresia and genetic cholestases / vascular diseases of the liver / developmental anomalies and malformative syndromes of ile-de-france / rare causes intellectual disabilities / complex congenital heart defects / childhood cerebrovascular pathologies) * patients who consulted between 1.1.2017 and 1.1.2020 the relevant rare disease reference center at necker hospital * patients seen at least once in the medical genetics department of necker hospital * information and non-opposition of adult patients / holders of parental authority of minor patients and minor patients to participate in the study exclusion criteria: patients who do not speak french

Keywords: rare diseases oral health-related quality of life qualitative method
effect of spencer muscle energy technique on pain in diabetic stiff shoulder

Conditions: Frozen Shoulder

Summary: stiff shoulder is a painful and severely debilitating condition. the inflammatory contracture of the glenohumeral joint capsule in stiff shoulder restricts both active and passive range of motion, with loss of external rotation being especially characteristic of this condition (dyer et al., 2023). stiff shoulder is clinically described by the continuing onset of shoulder pain and advanced exacerbation of the shoulder joint leading to exertion in the higher extremity activity, significant disability, and functional restrictions. the most common symptom of a stiff shoulder is night pain, resulting in sleep impediment that leads to one-sided sleep on the uninfected shoulder (mao et al., 2022). spencer technique is a standardized series of treatments with broad application to diagnose, treat and establish prognosis for restricted mobility in shoulder. it was developed by spencer in 1961. it is a multistep technique that combines spencer's positioning, sequencing, slow stretching of the shoulder complex within pain-free limits done by physical therapist while incorporating muscular energy with post-isometric contraction and relaxation (babu and putcha., 2022).

thirty diabetic female patients with stiff shoulder with ages 45-55 years: group a(study group) : 15 patients received spencer muscle energy technique along with postural exercise 3 times a week for 8 week. group b (control group) : 15 patients received classical physiotherapy treatment includes transcutaneous electrical nerve stimulation (tens) for 15 minutes hotpack on the painful area for 15 minutes along with postural exercise 3 times per week for 8 week.

Eligibility criteria:
inclusion criteria: * 1) women's age between 45 to 55 years old 2)suffering from stiff shoulder for 2-12 months (stage 1 and 2) confirmed by an orthopaedic specialist. 3) diagnosed as type 2 dm for at least 5 years. 4) no treatment other than analgesics exclusion criteria: * 1. cases of traumatic stiff shoulder. 2. osteoporosis and malignance of shoulder region. 3. neurological deficit affect shoulder function. 4. rheumatoid arthritis. 5. recurrent subluxation of shoulder. 6. cervical radiculopathy. 7. history of shoulder surgery. 8. vascular diseases.
impact of rheumatoid arthritis on the course of type 2 diabetes during a longitudinal follow-up of 5 years

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to determine whether patients with rheumatoid arthritis and type 2 diabetes experience a more severe disease course compared to control patients with osteoarthritis and type 2 diabetes


Eligibility criteria:
inclusion criteria: patients * adults (\>18 years) * rheumatoid arthritis fulfilling american college of rheumatology (acr )1987 or european league against rheumatism (acr/eular) 2010 classification criteria * type 2 diabetes (hba1c ≥6.5% or fasting glycemia≥7 mmol/l or glycemia 120 min after 75 mg glucose ingestion ≥ 11.1 mmol/l or symptoms of hyperglycemia with glycemia ≥11.1 mmol/l) * affiliated to social security system controls * adults (\>18 years) matched for age, sex and bmi with patients with rheumatoid arthritis * osteoarthritis (knee, hip, spine and hand) * type 2 diabetes with disease duration matched with patients with rheumatoid arthritis * affiliated to social security system exclusion criteria: * patient not able to understand study implication and rules * patient opposed to participate to the study * transient diabetes * gestational diabetes * secondary diabetes

Keywords: type 2 diabetes mellitus rheumatoid arthritis
laser therapy, pain and carpometacarpal joint osteoarthritis treatment

Conditions: Thumb Osteoarthritis; Pain; Physical Disorder

Summary: osteoarthritis (oa) is a chronic and prevalent joint disorder with great impact on quality of life and high economic burden. although a number of conservative therapies have proven to be effective for the management of hand oa, only modest treatment effects were reported for most individual interventions. the aim of the proposed study is to assess the effect of laser therapy on pain, function and force in patients with carpometacarpal osteoarthritis (cmc oa).

a randomized, controlled, single-center, double-blind, clinical trial, with 1:1 allocation ratio, were carried out involving patients diagnosis of cmc joint oa grade 1-2 (aged 18 years and above). both assessor and statistician remained blinded. the research diagnostic criteria for carpometacarpal joint osteoarthritis was used to assess all individuals who agree to participate. all participants were submitted to a clinical examination and x-ray assessment of thumb base to determine carpometacarpal osteoarthritis grade. based on the clinical and radiological findings, the participants were classified by a rheumatology. those with cmc oa grade 2-3 were included in the study. the experimental group received laser therapy and control group received a placebo treatment. the primary outcome measures was pain scores during daily living activities (dla)- at the base of the thumb measured with vas (unidimensional measure of pain: 0-10 (0, no pain and 10, worst pain), and changes in hand function measured using the quick-dash questionnaire. secondary outcome measures included changes in pinch strength. all outcome measures were collected at baseline, immediately following the intervention at 4 weeks and at 12 weeks following the end of the intervention.

Eligibility criteria:
inclusion criteria: * women over 18 diagnosis of cmc joint oa in their dominan hand. * state 1-2 according to the american college of rheumatology. * pain intensity during activities of daily living (adls) of up to 4 of 10 on the visual analog scale (vas) * ability to read or understand the patient information sheets. * ability to sign a consent form will be included in the study exclusion criteria: * neurologic disorder affecting the upper limb * previous treatment for their hand problem in the last 6 months including an intra-articular joint injection to wrist, fingers, or thumb * had fractures or a significant hand injury or previous surgery to the wrist, thumb or hand * finger tenosynovitis. * dupuytren disease. * psychological treatment.

Keywords: thumb osteoarthritis physical therapy pain
characteristics of people with advanced chronic obstructive pulmonary disease (copd) - a multicenter study

Conditions: COPD

Summary: pulmonary rehabilitation (pr) is a cornerstone of care for people with copd. there is robust evidence that pr improves exercise capacity, enhances health-related quality of life (qol) and reduces healthcare utilization. pr is strongly recommended in guidelines for copd management. despite the compelling evidence for its benefits, pr is delivered to less than 30% of people with copd. access is particularly challenging, an especially for those with the most progressed disease stages. we recently completed a randomized clinical trial, showing that approximately 1.100 patients annually are offered conventional hospital-based pr during routine consultations in the capital region of denmark, but at least 700 patients declines participation. no major cohort studies have been published from people with severe and advanced copd who opt out of traditional pulmonary rehabilitation. by establishing such cohort study, objective and qualitative knowledge from assessments and patient interviews is collected in patients we have very limited access to and knowledge of. additionally, the collected data will give a deeper insight and understanding and possibly enable us to design new delivery models to be tested in proper study designs.

objective this cohort study aims to describe and understand differences and similarities in characteristics among people with severe and advanced copd who opt-in or opt out of pr services. the study includes data from: socio-demographic, anthropometric, physical (function, activity, muscle strength, balance) characteristics as well as self-reported symptoms of anxiety, depression, fatigue, pain, lung symptoms, quality of life, sleep-quality, mortality, hospitaladmissions, length of stay and qualitative patient interviews. data from our completed trial study (nct02667171) will be used as the opt-in pr comparison cohort.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of copd defined as a ratio of forced expiratory volume at one second (fev1) to forced vital capacity \< 0.70 * fev1 \<50%, corresponding to severe or very severe copd * symptoms equivalent to the medical research council (mrc) from 2 to 5 * declines to participate in a conventional out-patient hospital-based pr program exclusion criteria: * concurrent participation in or recent completion of pulmonary rehabilitation within the last twelve months. * dementia/ cognitive impairment or uncontrolled psychiatric illness, * an impaired hearing and / or vision which causes the instructions in the assessment is not understood. * language difficulties which causes inability to follow instruction or complete patient reported outcome measures (prom.) * any comorbidity that are contraindicated to the assesment protocol.
the effect of general anesthesia immunosuppressive on hepatitis b virus replication

Conditions: HBV Infection

Summary: the purpose of this study is to determine whether the general anesthesia immunosuppressive could effect hepatitis b virus replication

the change of immune state can influence hbv replication or elimination, it has been reported that a certain degree of immunosuppression occured after general anesthesia. in this study we detect the cytotoxic t lymphocyte(ctl) count and activity, interferon-γ(ifn-γ) and hbv-dna content form the hbv patient who will accept general anesthesia. our purpose is to evaluate the influence of general anesthesia immunosuppressive on hbv replication. if the results show that hbv-dna quantity increases, so the patients might be given anti-hbv drugs or immune enhancer; otherwise it is indicated the general anesthesia immunosuppressive don't influence hbv replication.

Eligibility criteria:
inclusion criteria: 1. american society of anesthesiologists（asa） ⅰ - ⅱ; 2. ability to compliance the research plan; 3. volunteered and signed for the study ; 4. hbsag positive, no serious system disease (heart: new york heart association（nyha） class ⅰ - ⅱ, lung: vital capacity（vc）% or maximal voluntary ventilation（mvv）%\>71, forced expiratory volume at one second（fev1.0）%\>61, arterial oxygen saturation（sao2）%\>94, arterial partial pressure of oxygen（pao2）\>75 mmhg, arterial carbondioxide partial pressure（paco2）\<45mmhg, liver:child-pugh class a - b and kidney: chronic kidney disease（ckd）stage 1-3); 5. receive under general anesthesia (including gynecology, orthopedics,general surgery and urology department). exclusion criteria: 1. asa\>ⅱ; 2. tumor patients 3. can't collaborate;

Keywords: need general anesthesia
study of a multimodality pain management protocol on postoperative neurosurgical pain

Conditions: Pain; Postoperative Pain; Surgical Pain; Neurosurgical Pain

Summary: high levels of postoperative pain are associated with an increased risk of lung and heart complications, are the most common reason for delayed discharge or for unexpected hospital admission after ambulatory surgery, and are responsible for prolonged recovery after inpatient surgery. furthermore both neuropathic pain and post surgical pain inhibit weight gain and may have an impact on the patient's nutrition post operatively. the purpose of this study is to evaluate the effectiveness of a multimodality pain management protocol on postoperative neurosurgical pain.

despite the long-standing recognition of postoperative pain as both prevalent and undertreated, 20% to 30% of all surgical patients continue to experience moderate to severe postoperative pain. high levels of postoperative pain are associated with an increased risk of pulmonary and cardiovascular complications, are the most common reason for delayed discharge or for unexpected hospital admission after ambulatory surgery, and are responsible for prolonged convalescence after inpatient surgery. furthermore both neuropathic pain and post surgical pain inhibit weight gain and may have an impact on the patient's nutrition post operatively. finally, high levels of postoperative pain have also been associated with an increased risk of chronic pain. therefore, the aggressive treatment of postoperative pain may be particularly important in influencing patient outcomes, inadvertent readmissions, and propensity for developing chronic pain.

Eligibility criteria:
inclusion criteria: * postoperative neurosurgical patient treated at the university of florida * primary language is english exclusion criteria: * younger than 18 or older than 100 years of age * patients who are pregnant, wards of the state, prisoners, and patients who lack the ability to communicate their pain level

Keywords: pain postoperative pain surgical pain neurosurgical pain
antenatal testing in obese woman, is it really necessary?

Conditions: Obesity in Pregnancy

Summary: it is well established that obese women are at an increased risk of stillbirth compared to non obese women. this has led many physicians to begin antenatal testing in obese women in the third trimester through either nonstress tests or biophysical profiles. however, there is little evidence that antenatal testing improves fetal outcomes in obese women. the aim of this study is to determine if antenatal testing improves outcomes in obese women and to determine the optimal mode of testing (either nonstress tests or biophysical profiles).

1. purpose: to determine if antenatal testing improves outcomes in obese pregnant women 2. rationale: it has been well established that obese pregnant women are at increase risk of stillbirth compared to matched non obese controls. this relative risk is increased not only with increasing gestational age in obese women but with increasing severity of obesity. the increased risk of stillbirth has led some obstetricians to begin antenatal testing in obese women; however, there is little evidence that antenatal fetal surveillance improves outcomes. 3. study/project population: pregnant women before 32 weeks of gestation with an initial bmi \>30kg/m2 4. research design: randomized controlled trial 5. study/project procedures: patients will be randomized to one of three groups: daily kick counts only, nonstress test, amniotic fluid index, and daily kick counts, and biophysical profile and daily kick counts. these patients will be randomly assigned a group in a 1:1:1 ratio using a random number generator available online. patients assigned to the daily kick counts only group will be called weekly to ensure they are doing daily kick counts. if they are noncompliant, they will be removed from the study and will undergo nonstress tests if they meet the initial bmi criteria as is the standard practice at our institution. 6. outcomes measured: stillbirth, induction of labor, mode of delivery, neonatal intensive care unit admission, agpars \<7 at 5 minutes of life

Eligibility criteria:
inclusion criteria: less then 32 weeks gestation bmi \> 30kg/m2 english speaking exclusion criteria: age \ 45 medical comorbidity which requires antenatal testing other than obesity unwilling to consent non-english speaking not pregnant gestational age \>32 weeks
impact of somatosensory intensive intervention on motor performance in children with unilateral cerebral palsy

Conditions: Unilateral Cerebral Palsy

Summary: this study aims to investigate the effectiveness of an intensive somatosensory intervention in the upper limb of children with hemiparesis regarding structure, function, activity and participation hypothesis: intensive somatosensory activity based intervention is effective in upper limb and hand ability in children with hemiparesis, specially regarding activity and participation

feasibility and longitudinal study with blinding of the evaluator and the person analyzing the data. the study have 4 procedures: 1. - assessment pre-intervention 2. - intervention: three weeks 3. - assessment post-intervention 4. - follow-up assessment (three months after intervention).

Eligibility criteria:
inclusion criteria: * diagnosis of unilateral cerebral palsy * manual ability classification system (macs): levels i, ii y iii. * gender: male and female * age: 6 to 15 years old exclusion criteria: * existence of a moderate or severe cognitive impairment, which could interfere with the comprehension of the tester cues * botulinum toxic infiltration 4 months before the date of the pre-intervention assessment or during intervention or during the 3 months after the final intervention * to have suffered any injury such as fractures and/or contusions in the upper limb in the last 12 months * orthopedic intervention in the 6 months preceding the study or during the study

Keywords: somatosensory intensive intervention somatosensory processing motor performance participation quality of live occupational performance