Kornimate/medical-research-clean huggingface dataset:
the effect of oral zinc supplementation on thiol oxido-reductive index

Conditions: Asthenozoospermia

Summary: although several studies have considered the relationship between infertility and semen thiol compounds levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on thiol related enzymes activity which are important in fertility of the individual has been reported.

the present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with reduced thiol, oxidized thiol and thiol related enzymes in the seminal plasma of asthenospermic patients.

Eligibility criteria:
inclusion criteria: * the presence of asthenozoospermia in the semen sample. exclusion criteria: * the absence of endocrinopathy, varicocele, and female factor infertility. smokers and alcoholic men were excluded from the study because of their recognized high seminal ros levels and decreased antioxidant levels.

Keywords: zinc supplementation thiol glutathione peroxidase sulfhydryl oxidase
nurse-provided care or standard care in treating patients with stage i, stage ii, or stage iii breast cancer

Conditions: Breast Cancer; Fatigue; Nausea and Vomiting; Pain

Summary: rationale: meeting with a nurse to assess symptoms and quality of life may be more effective than standard care in treating patients with breast cancer. purpose: this clinical trial is studying nurse-provided care to see how well it works compared with standard care in treating patients with stage i, stage ii, or stage iii breast cancer.

objectives: * to compare the effects of an advanced practice nurse, standardized nursing intervention protocol (snip) model vs usual care on overall quality of life and psychological distress of patients with stage i-iii breast cancer, from initial treatment to 6 months post diagnosis. * to compare symptom control in these two groups. * to compare geriatric assessment outcomes in these two groups. * to test the effects of the snip intervention as compared to the usual care group on resource use by these patients. * to test the effects of snip on patients' and clinicians' satisfaction with care. * to describe the effects of snip on patients' management of transitions from one phase of chronic illness to another. * to identify subgroups of these patients who benefit most from the snip in relation to sociodemographic characteristics, disease/treatment factors, and geriatric assessment predictors. * to obtain feedback from clinicians regarding interpretation of findings and application to the routine care of breast cancer patients. outline: patients are enrolled sequentially to 1 of 2 groups. group 1 is enrolled during months 4-21 and group 2 is enrolled during months 25-54. * group 1 (usual care): patient questionnaires are administered at baseline and at 3 and 6 months. the clinicians' satisfaction with care is also evaluated. * group 2 (advanced practice nurse \[apn\] intervention): patients are accrued by an apn. patients meet with the apn periodically to assess their physical well-being including ambulatory care needed, care of physical symptoms (i.e., pain, fatigue, nausea and vomiting), and psychological well-being. questionnaires are administered at baseline and at 3 and 6 months. in both groups, questionnaires include the fact-breast, memorial symptom assessment scale, psychological distress thermometer, comprehensive geriatric assessment, and patient satisfaction with intervention. clinicians also complete questionnaires. patients' medical charts are also reviewed.

Eligibility criteria:
disease characteristics: * diagnosis of stage i, ii, or iii breast cancer * admitted to city of hope national medical center * resides within a 30-mile radius of the medical center * hormone receptor status not specified patient characteristics: * menopausal status not specified * no prior cancer prior concurrent therapy: * not specified

Keywords: pain fatigue nausea and vomiting stage i breast cancer stage ii breast cancer stage iiia breast cancer stage iiib breast cancer stage iiic breast cancer
evaluation of the impact of taking american ginseng for 8 weeks on fatigue in patients treated for localized breast or gynecological cancer

Conditions: Breast Cancer; Fatigue

Summary: this is a multicenter randomized trial in breast cancer patients reporting cancer-related fatigue to evaluate the efficacy and safety of qiseng® based on extract of american ginseng combined with vitamin c from extract of camu camu berries


Eligibility criteria:
inclusion criteria: * patients with localized breast or gynecological cancer treated as curative adjuvant and/or neoadjuvant chemotherapy and/or adjuvant radiotherapy. these treatments must have been completed within 6 months of inclusion. * patient reporting a chronic, stable fatigue state at investigator assessment, defined as a fatigue score ≥ 4 on the visual analog scale rated up to 10, experienced for at least one month * maintenance therapy with hormone therapy or other maintenance therapy (trastuzumab, bevacizumab...) is allowed before and/or during the study (except for pembrolizumab, abemaciclib and parp inhibitors, which are not authorized) * patient 18 years of age or older * effective contraception in women of childbearing age * patient affiliated to a social security plan * signed informed consent exclusion criteria: * other identified causes of fatigue (anemia of grade \&gt; 2, underlying chronic disease known to be associated with fatigue) * ongoing chemotherapy (patients scheduled for oral capecitabine or trastuzumab-emtasin in the adjuvant setting are not eligible) * metastatic breast or gynecological cancer * ongoing treatment with a tyrosine kinase inhibitor or other p-gp transported molecule or pembrolizumab or parp inhibitors * patient requiring oral diabetes therapy * regular intake of vitamin c (in addition to what is provided by the diet) * patients with chronic pain requiring daily treatment with analgesics, anti-inflammatory drugs or corticosteroids * consumption of ginseng-based products in the month prior to inclusion * hypersensitivity to any of the components of qiseng or placebo * pregnant or breastfeeding patient * simultaneous participation in another therapeutic clinical trial (trial using an experimental product) * patient deprived of liberty, under guardianship or curatorship * patient unable to undergo the medical follow-up of the trial for geographical, social or psychopathological reasons * history of any other malignant disease during the last 3 years, except for skin cancer other than melanoma, carcinoma in situ of the uterus. any other solid tumor or lymphoma (without bone marrow involvement) must have been treated and show no signs of recurrence for at least 3 years

Keywords: qiseng food supplement
anti-mullerian hormone (amh) is a marker for ovarian reserve. there are many studies about amh changes in ovarian surgery, but little is known for other surgeries. we seek to investigate the hormone variations before and after uterine artey ligation for postpartum hemorrage (pph)

Conditions: Anti-Mullerian Hormone Deficiency; Post Partum Hemorrhage

Summary: anti-mullerian hormone (amh) is a marker for ovarian reserve. there are many studies about amh changes in ovarian surgery, but little is known for other surgeries. we seek to investigate the hormone variations before and after uterine artey ligation for postpartum hemorrage (pph)

all patients belong to the same group. the blood samples will be collected at the time of surgery and 3 months after surgery from the patients who need uterine artery ligation for pph. the blood samples will be centrifuged within 2 hours after being obtained and assessed on the same day. amh concentrations will be measured with an enzymatically amplified two-sided immunoassay

Eligibility criteria:
inclusion criteria: * age 18- 40 years * no systemic or endocrine diseases * patients who had uterine artery ligation due to pph exclusion criteria: * pregnancy with ivf or oosit donation * patients with endocrinopathy, diseases which require radiotherapy and chemotherapy etc. * patients with bmi \>40
feasibility trial of intraperitoneal chemotherapy for ovarian, fallopian tube, and primary peritoneal carcinoma

Conditions: Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Carcinoma; Uterine Cancer

Summary: the purpose of this study is to evaluate giving chemotherapy drugs directly into the abdomen (belly) along with intravenous administration.

giving chemotherapy directly into the abdomen is called intraperitoneal (ip) chemotherapy. because ovarian, fallopian, primary peritoneal and uterine cancer spread in the abdominal cavity, giving chemotherapy drugs by infusion into the abdominal cavity may result in a greater dose of the drugs reaching the tumor cells. intraperitoneal treatments will be administered through an implantable peritoneal catheter. these catheters are to be inserted into the peritoneal cavity, tunneled through the subcutaneous tissue, and connected to an implantable port, which is placed in the subcutaneous tissue of the anterior, inferior thorax.

Eligibility criteria:
inclusion criteria: * patients with stage ia, ib, ic, ii, iii, iv and recurrent platinum sensitive epithelial ovarian carcinoma, fallopian tube carcinoma, primary peritoneal carcinoma, or ovarian carcinosarcoma. histologic subtypes which are eligible include serous adenocarcinoma, endometrioid adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, mixed epithelial carcinoma, transitional cell carcinoma, malignant brenner's tumor, adenocarcinoma (not otherwise specified), and carcinosarcoma. * patients with advanced endometrial carcinoma, of any histology, including endometrioid adenocarcinoma, clear cell adenocarcinoma, and serous papillary carcinoma. * patients with uterine carcinosarcoma of any stage are eligible. exclusion criteria: * patients with epithelial ovarian carcinoma of low malignant potential (borderline carcinomas). * patients with septicemia, severe infection, or acute hepatitis. * patients with prior malignancy or cancer treatment within the last five years.

Keywords: ovarian cancer fallopian tube cancer primary peritoneal carcinoma uterine cancer intraperitoneal chemotherapy ip chemotherapy gynecologic cancer women's cancer cisplatin paclitaxel recurrent platinum sensitive ovarian cancer
rainbow acoustic monitoring (ram) in patients weighing up to 10kg comparison study

Conditions: Respiration Rate

Summary: the objective of this clinical investigational study is to compare the acoustic respiration rates (rra) obtained using the invsensor0004 sensor in the subjects up to 10 kg with the respiration rates determined by manual annotations (rrref), and when applicable with capnography respiration rate (rrcap).


Eligibility criteria:
inclusion criteria: * subjects weighing up to 10kg * subjects will be inpatients and/or outpatients admitted to the nicu (neonatal intensive care unit) or picu (pediatric intensive care unit) or pacu (post-anaesthesia care unit) * the parent/legal guardian has given written informed consent/assent to participate in the study. exclusion criteria: * subjects with underdeveloped skin * subjects with skin abnormalities at the planned application sites that may interfere with sensor application, per directions-for-use (dfu) or trans-illumination of the site, such as burns, scar tissue, infections, abnormalities, etc. * subjects deemed not suitable for the study at the discretion of the investigator.
transcranial bright light therapy in seasonal affective disorder (sad)

Conditions: Seasonal Affective Disorder (SAD)

Summary: bright light therapy (blt) has been found to be effective in treatment of seasonal affective disorder (sad). the mechanism of action of conventional blt in the treatment of sad is under debate. recently, transcranial bright light (tbl) via ear canals has been proved to modulate the neural networks of the human brain and improve cognitive performance in healthy subjects. moreover, tbl has been found to alleviate symptoms of sad in open trial. in this case the investigators will study the effect of transcranial bright light treatment via ear canals on depressive and anxiety symptoms in patients suffering from sad in randomized controlled double-blind study design.


Eligibility criteria:
inclusion criteria: * patient has (according to the diagnostic and statistical manual of mental disorders, fourth edition, text revision \[dsm-iv-tr\]) a major depression, recurrent episode, seasonal pattern * structured interview guide for the hamilton depression rating scale - seasonal affective disorder version self rating version (sigh-sad-sr) score ≥ 16 * patient is over 18 years and under 66 years * patient can read and understand the subject information sheet * patient has signed the informed consent form * patient is not pregnant exclusion criteria: * patient has a lifetime psychotic disorder * patient has a bipolar disorder * patient has alcohol or some other substance use dependence or misuse * patient has some unstable somatic disorder * patient uses some psychotropic agencies * patient is, in the opinion of the investigator, unsuitable for any reason * patient is a member of the site personnel or their immediate families * patient has administered bright light therapy via ear canals during the current episode
reactive vs. proactive pain control in ibd

Conditions: Inflammatory Bowel Diseases; Pain; Opioid Use; Crohn Disease; Ulcerative Colitis

Summary: the investigators will compare two physician behaviors for managing pain in patients with ibd: proactive vs. reactive. both the proactive and reactive behavior/strategies are standard of care at the institution in which the study will be performed. the proactive strategy is an ibd-specific analgesic orderset (built into our emr and approved by the institution's pharmacy and therapeutics committee), the reactive strategy is a traditional "reactive" analgesic prescribing (prescribing medications only when patients have pain). the proactive ibd-specific analgesic orderset consists of medications which have evidence for use in ibd-related pain. this orderset is an educational guide, it does not force any order. the reactive prescribing habits could contain an array of pain medications depending on what the provider wants to prescribe. aims: aim 1: to assess whether there is a difference in pain scores or functional activity among hospitalized patients with ibd between reactive vs proactive physician behaviors. aim 2: to assess whether there is a difference in inpatient opioid-prescribing between reactive vs proactive physician behaviors. aim 3: to assess whether there is a difference in health care utilization, including length-of-stay and 30-day readmission, between reactive vs proactive physician behaviors.

prospective, investigator-blinded, single-institution randomized-control trial . consecutive adult patients with ibd (crohn's disease or ulcerative colitis) admitted to the hospital will be screened for eligibility, and eligible patients will be approached and consented to participate. subjects will be randomized to receive the p.a.i.n.-sparing bundle or usual care. patient randomization will be stratified by provider to avoid bias, using a web-based in-house system (randi3). subjects will also be provided with a fitness tracker (fitbit(r)) to measure functional status during their hospital stay.

Eligibility criteria:
inclusion criteria: * adults with confirmed ibd diagnosis * admitted for primary ibd-related sign or symptom exclusion criteria: * admitted for primary non-ibd complaint * surgery in the last 30 days * alternative (non-ibd) gi diagnosis determined * age \<18 * pregnancy

Keywords: pain inflammatory bowel disease opioids
pharmacological effects of neurapas® balance and pascoflair® 425 mg on brain activity in healthy volunteers

Conditions: Healthy

Summary: to evaluate the pharmacological effects of two herbal medicinal products (neurapas balance and pascoflair 425 mg) in comparison to placebo on brain activity.

evaluation of the pharmacological effects of neurapas® balance and pascoflair® 425 mg by quantitative measurement of brain activity in 16 healthy volunteers.

Eligibility criteria:
inclusion criteria: * healthy male and female volunteers * 30 - 70 years (extremes included) * medical history without any study relevant pathological findings * written and signed informed consent exclusion criteria: * clinically study relevant acute or chronic disorders, that can be detected by clinical investigation or medical history * clinical, study-relevant pathological findings of clinical oar laboratory investigations * clinically relevant pathological eeg findings (e.g. artefact-free parts in screening-eeg \<30% in one recording * clinically relevant allergies * positive alcohol testing on screening, day a, b, or c, or anamnestic * positive drug screening test on screening, day a, b, or c, or anamnestic * intake of study relevant medication 14 days prior to active day a, or during active study duration, based on the volunteer´s information * regular intake of drug with primary central nervous effects (e.g. psychoactive drugs or central acting antihypertensive drugs) * known hypersensitivity / allergy against herbal extracts (i.e. dry extracts of passionflower herb, st. john´s wort herb, valerian root) or lactose or an other excipient of the investigational medication * lapp-lactase deficiency (anamnestic) * hypersensitivity of the skin (anamnestic) * bmi (body-mass-index) \ 30 * abuse of caffeine, teeine, or tobacco * smoking in the investigational site on day a, b, or c * participation in an other clinical study within 60 days prior to screening * positive pregnancy test (on screening, day a, b, or c) or lactation * bad compliance * revocation of informed consent

Keywords: qeeg herbal medicine cognitive function neurapas balance pascoflair hypericum passionflower valerian healthy volunteers influence on quantitative electro-encephalogram (qeeg).
yoga as an intervention for women with knee osteoarthritis

Conditions: Osteoarthritis

Summary: keeping individuals with knee osteoarthritis physically active is critically important. exercise is effective at reducing pain while improving physical function. however some exercises can overload the knee, and as a result, worsen knee pain and health of the knee joint. yoga offers a foundation of static postures that improve muscle strength and joint flexibility. using sophisticated technology that allows us to calculate the loads inside the knee, the investigators have selected yoga exercises that do not overload the knee joint. the investigators have designed a yoga exercise class that is ideal for people with knee osteoarthritis. the purpose of the study is to investigate whether these yoga exercises increase muscle strength and reduce knee pain in women with knee osteoarthritis. in addition, the investigators aim to show that these yoga exercises will also improve knee loads during activities, mobility and heart health. the investigators will ask 50 women with knee osteoarthritis to participate in a 12 week yoga exercise intervention, that requires attendance to 3 classes each week. the investigators will test strength of the leg muscles, pain, knee joint loads, mobility and cardiovascular health before and after the 12 week yoga exercise intervention.

this study is an uncontrolled intervention study with repeated measures. the intervention is a 12-week supervised exercise class featuring biomechanically sound exercises for people with knee osteoarthritis. measures of strength of the knee muscles, pain, biomechanics during walking and yoga, mobility and cardiovascular health will be included. strength will be measured on a dynamometer. pain will be assessed with questionnaires. walking and three yoga postures will be observed using motion capture system integrated with force measurements from the floor. mobility will be assessed during walking, stair-climbing and chair standing tasks. cardiovascular health will be measured during a submaximal bicycle task.

Eligibility criteria:
inclusion criteria: * female - 50 years of age or older * knee pain on most days of the week * less than 30 minutes of morning stiffness * bony enlargement * bony tenderness to palpation * signs of inflammation * able to safely climb 2 flights of stairs without aid * visited a family physician within the last 12 months exclusion criteria: * any other forms of arthritis * osteoporosis * history of patellofemoral symptoms * active non-arthritic knee disease * knee surgery * use of cane or walking aid * unstable heart condition * neurological conditions * skin allergy to medical tape * hip or ankle injuries in past 3 months * any injuries that would prohibit participation in yoga * ipsilateral hip or ankle conditions * currently receiving cancer treatment * currently pregnant
refractive accuracy of "2win" and portable autorefractors

Conditions: Refractive Error - Myopia Axial; Astigmatism; Accomodation; Visual Impairment; Hyperopia of Both Eyes

Summary: youth and some adults have photoscreening refractions and hand-held auto refraction before cycloplegia refraction during new and follow up eye examinations. vector math is applied to each refraction to determine how closely the hand-held "dry" devices match actual refraction.

a closeness-of-fit algorithm utilizing vector transformations of astigmatism is designed and applied to 50-years of clinical international refractive experience. as a part of new and follow up comprehensive eye examinations, patients and parents consented to confirm the cycloplegic refraction to other portable refractive tools. the ability of photoscreeners "2win" ("adaptica," padova italy), "plusoptix a12" (nuremberg, germany) and "retinomax" (righton, tokyo, japan) to match actual refraction is assessed utilizing the new algorithm. this algorithm could then be applied to batches of donated spectacles distend by charitable organizations worldwide if portable auto refracting devices are employed.

Eligibility criteria:
inclusion criteria: * patient undergoing new or follow examination at pediatric eye and adult strabismus clinic willing to undergo screening refractive device developmental delays included exclusion criteria: * intraocular lens in place

Keywords: photoscreening photo refraction auto refraction spectacle dispensing