Kornimate/medical-research-clean huggingface dataset:
effects of vitamin d on inflammation in liver disease

Conditions: Hepatitis C Infection; Vitamin D Deficiency

Summary: chronic liver diseases are associated with inflammation. the investigators postulate that vitamin d may modulate inflammation. thus the investigators will study the effect of vitamin d replacement in patients with hepatitis c infection and vitamin d deficiency.

vitamin d appears to be a critical signaling molecule for macrophages because is needed for activation and differentiation of monocytes/macrophages. from our preliminary studies( va merit review grant), we propose that vitamin d deficiency may alter the 'pro-inflammatory' ('classically activated') m1 macrophages , characterized by i\] high expression of nos2, tnf-a, il-1, il-6, il-8, tgf-a, cxcl10, and ccl19; and ii\] minimal expression of arginase 1 and mannose r. the clinical relevance of these findings is suggested by the presence of activated m1 macrophages in liver biopsies from patients with severe drug-induced liver injury (unpublished observations). prospective vitamin d supplementation studies with appropriate endpoints are needed to define the role of vitamin d on inflammation in patients with chronic liver diseases.

Eligibility criteria:
inclusion criteria: * men or women aged 18 or older * total 25-oh vit d \< 25 ng/ml * infection with hcv genotype 1 (subjects infected with multiple genotypes are not eligible). * plasma hcv rna concentration of \>100,000 iu/ml. * hcv-infected subjects naïve to treatment: subjects who either have never been treated for hcv infection or who previously received hcv treatment ending \> 3 months prior to enrollment (including, any ifn-alpha with or without ribavirin, or other anti-hcv antiviral medication). exclusion criteria: * women who are pregnant or breastfeeding. * patients with sarcoidosis, histoplasmosis, lymphoma, primary hyperparathyroidism or idiophatic hypercalcemia. * liver cirrhosis. * known active gastrointestinal disease that could interfere with the absorption of the test article. * laboratory determinations at screening as follows: * hemoglobin \<10 g/dl . * serum creatinine that is not within normal limits. however, such subjects may be enrolled if the cockroft-gault glomerular filtration rate (gfr) is \> 50 ml/minute. * unstable hypertension, cardiac disease or type 2 diabetes requiring changes in treatment with medications 4 weeks prior to screening or during the screening period. * use of an investigational drug within 4 weeks before the screening visit or during the screening period. * use of systemic immunosuppressants (including systemic, oral, or intravenous corticosteroids) or immunomodulating agents within 4 weeks before the screening visit or during the screening period.
clinical evaluation of bcdx for monitoring of recurrence in non-muscle invasive bladder cancer

Conditions: Bladder Cancer

Summary: bcdx is a urine-based multi-omic assay for early cancer recurrence detection in patients with a history of bladder cancer. this prospective, blinded study evaluates its efficacy in detecting recurrent nmibc, offering a noninvasive monitoring solution.

bcdx is a urine-based multi-omic/multiplex molecular assay offers a promising solution for detecting cancer recurrence. it is intended for use as a noninvasive method for monitoring for tumor recurrence in conjunction with cystoscopy inpatients previously diagnosed with bladder cancer. this is a, multicenter, prospective, blinded study to evaluate the efficacy (sensitivity and specificity) of a novel multi-omics test for the detection of recurrent nmibc in patients with a history of bladder cancer undergoing surveillance.

Eligibility criteria:
inclusion criteria: * patients 18 years and older * patients who have been diagnosed with incident or recurrent nmibc within the past 2 years and undergoing standard of care/routine monitoring cystoscopy. * patients who are able to provide legally effective informed consent. * patients who are able to provide minimum 30ml of voided urine. exclusion criteria: * patients planning to undergo radical cystectomy or chemotherapy-radiation for urothelial cell carcinoma.
automatic diagnosis of spinal stenosis on ct

Conditions: Spinal Stenosis

Summary: mri is a common tool for radiographic diagnosis of spinal stenosis, but it is expensive and requires long scanning time. ct is also a useful tool to diagnose spinal stenosis, yet interpretation can be time-consuming with high inter-reader variability even among the most specialized radiologists. in this study, the investigators aim to develop a deep-learning algorithm to automatically detect and classify lumbar spinal stenosis.

mri is a common tool for radiographic diagnosis of spinal stenosis, but it is expensive and requires long scanning time. ct is also a useful tool to diagnose spinal stenosis, yet interpretation can be time-consuming with high inter-reader variability even among the most specialized radiologists. in this study, the investigators aim to develop a deep-learning algorithm to automatically detect and classify lumbar spinal stenosis. it would be a time-saving workflow if the software can assist the radiologists to detect and locate the suspected lesion.

Eligibility criteria:
inclusion criteria: * age \>18 years * with radiologists' ct reports on cervical, thoracic and lumbar stenosis exclusion criteria: * not applicable (only specific levels with extensive infections, fractures, tumor, high-grade spondylolisthesis would be excluded for analysis).
safety and effectiveness of intermittent hypoxia treatment in parkinson's disease

Conditions: Parkinson Disease

Summary: to explore the safety, feasibility and net symptomatic effects of multiple (3x/week, for 4 weeks) intermittent hypoxia treatment sessions in individuals with pd. secondary outcomes include exploring induction of relevant neuroprotective pathways as measured in serum.

intermittent hypoxia therapy is a non-pharmacological intervention used by athletes and individuals with cardiovascular disease, amongst others. the safety and feasibility of (intermittent) hypoxia therapy and its short-term effects on parkinson's disease (pd) symptoms were assessed in a previous exploratory phase i trial. however, the net effects of multiple hypoxia treatment sessions on pd symptoms are unknown. the results of the previous phase i trial informed the study design of the newly proposed phase 1b-2a safety and efficacy trial. 45 minutes of normobaric intermittent hypoxia (fio2 0.16 for 5 minutes interspersed with 5 minutes normoxia) will be delivered via a hypoxicator (a device that titrates decreased fractional oxygen from room air) through an oxygen mask in the hospital and subsequently at participants' homes. interventions will be conducted 3 times a week, for 4 weeks in total.

Eligibility criteria:
inclusion criteria * informed consent * clinical diagnosis of parkinson's disease by a movement disorder specialized neurologist. * hoehn and yahr staging 1 to and including 3 (indicating mild to moderate pd). exclusion criteria a potential subject who meets any of the following criteria will be excluded from participation in this study: * individuals with diseases leading to restrictive and obstructive pulmonary diseases, sleep apnea and cardiac output deficits, such as pulmonary fibrosis, copd, sleep apnea or excessive alcoholic intake, and congestive heart failure respectively * individuals with coronary artery disease nyha classes iii and iv * arterial blood gas abnormalities at screening procedure * individuals with shortness of breath or other airway or breathing-related inconvenience related to lack of dopaminergic medication * inability for in-clinic measurements in off phase * individuals with active deep brain stimulation
adapted physical activity centre (in the) city for elders aged 70 and over with at least one long term illness

Conditions: Chronic Disease

Summary: elders aged 70 and over, living in toulouse, with a chronic disease identified by the french social insurance as an affection longue durée will be eligible to a 4 months physical activity program in a primary health center. this program will be proposed by their general practitioner. the aim of the study is to establish the feasibility of such program conduced exclusively in primary care.

the number of elders aged 70 and over and suffering of a chronic disease are increasing in our country. these patients are at risk of sarcopenia which can lead to an increasing risk of falls and hospitalization, loss of autonomy, and morbi-mortality. twelve weeks adapted physical activity program can manage sarcopenia in elders. one of the difficulties to propose such a program to elders patients is the difficulty to reach the program center due to mobility deficiency. our hypothesis is that proposing an adapted physical activity in a primary health care center, in the city of the patient, could help the participation. eligible patients addressed by their general practitioner will perform 4 months adapted physical activity program in the capa-city center (mspu la providence). the inclusion will be realized by the sports doctor of capa-city. at m2, sport doctor and adapted physical activity teacher will meet the patient to readapt the program taking in count his particularity and wishes. at m4 m6 and m12, an independent global evaluation will be realized by training nurse and clinical research associate.

Eligibility criteria:
inclusion criteria: * elders aged 70 and over, with a chronic disease recognize as an long term affection by the french social insurance. * living at home in toulouse * with a general practitioner working in toulouse and agreed to participate to the capa-city70 program research exclusion criteria: * elders living in nursing home * elders dependent for daily activity (score \< 5.5 autonomy scale of katz) * elders with dementia according to dsm v criteria * elders participating in another research project * contraindication for physical activity

Keywords: chronic disease adapted physical activity primary care motor activity elders
troponin leaks in emergency department patients presenting with supraventricular tachycardia (svt)

Conditions: Supraventricular Tachycardia

Summary: the goal of this study is twofold. first the investigators would like to determine the trajectory of troponin leaks; if it can be shown that the participants who have only minimal elevations of their repeat troponin universally decrease on the 3rd level then future patients may see significantly improved length of stay. second, given conflicting results in the literature, the investigators would like to determine if elevated troponin levels correlate to later cardiovascular complications. these complications will be defined as death, myocardial infarction, cardiovascular intervention (such as coronary artery stenting or bypass). as the investigator is a single hospital system in this county it is uniquely positioned to be able to review this retrospectively.

the investigators therefore propose retrospectively studying participants diagnosed with supraventricular tachycardia who had troponin(s) checked in the ed between january 1, 2012 and may 31, 2016 to allow a minimum of a year follow-up for our combined endpoint. the investigators will record the participants troponin value(s) in addition to the age, sex, race, heart rate, creatinine value. the investigators will compare the participants with positive troponins (and hopefully participants with strongly positive troponins) with those who are negative for troponin for presence of the combined end point via chart review.

Eligibility criteria:
inclusion criteria: * supraventricular tachycardia with troponin elevation exclusion criteria: * other cardiac arrhythmias or conditions with increased troponin

Keywords: troponin
benefit of transcutaneous auricular vagus nerve stimulation in improving quality of life in first line treatment of ovarian cancer:

Conditions: Ovarian Carcinoma; First Line Chemotherapy; Digestive System Disorders

Summary: impact of stimulation of parasympathetic activity by transcutaneous auricular vagus nerve stimulation (tavns) on quality of life (qol) relating to digestive symptoms in patients undergoing first-line treatment for ovarian cancer, as compared to shame tavns

impact of stimulation of parasympathetic activity by transcutaneous auricular vagus nerve stimulation (tavns) on quality of life (qol) relating to digestive symptoms in patients undergoing first-line treatment for ovarian cancer, as compared to shame tavns randomization between: * experimental group: transcutaneous auricular vagus nerve stimulation (tavns) * control group: placebo using the same device that does not deliver electrical stimulation

Eligibility criteria:
inclusion criteria: * patient ≥ 18 years old * ecog 0-2 * histologically proven epithelial ovarian carcinoma * figo stage ≥ iib * patient candidate for first line chemotherapy treatment (alone, neoadjuvant or adjuvant) * patient affiliated to an appropriate social security system * patient who has signed informed consent obtained before any trial related activities exclusion criteria: * patient with an active implantable medical device or any other implanted electronic or electrical device (pacemaker, defibrillator, etc.) * dermatological problems in the area where stimulation electrodes are applied * recent history (\<2 years) of epileptic seizures * proven severe cardiovascular disease (such as known fev \<40%, severe valvulpathy...) or hrv analysis not possible (such as uncontrolled atrial fibrillation) * serious ear pathology * documented vegetative neuropathy * unusual morphology of the left ear which does not allow the use of the device * patient with a cochlear implant near to the stimulation site * impaired cognitive abilities * concurrent other malignancy (except for appropriately treated in-situ cervix carcinoma and non-melanoma skin carcinoma) * pregnant or breastfeeding woman * simultaneous participation in another clinical study that may compromise the conduct of this study. * patient assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol * patient deprived of liberty or placed under the authority of a tutor

Keywords: ovarian carinoma parasympathetic vagus nerve transcutaneous auricular stimulation quality of life digestive symptoms
comparison of double-kissing crush and double-kissing culotte stenting

Conditions: Coronary Artery Disease

Summary: true bifurcation lesions (tbls) are not rare clinical conditions and may be associated with adverse cardiovascular outcomes due to their complex anatomy and the variety of interventional therapy. although the provisional stenting is still effective in suitable lesions, double stent techniques can be required in selected patients. in previous studies, double kissing crush (dk-crush) stenting was revealed as superior to provisional stenting in tbl of left main coronary artery. additionally, in recent studies, double kissing approach facilitates and highlights double kissing culotte (dk-culotte) stenting with lower stent malapposition compared to dk-crush stenting. however, to the best of our knowledge, there is no study about comparing dk-crush and dk-culotte stenting in tbls. our aim in this study is to compare dk-crush and dk-culotte stenting in patients with tbl.


Eligibility criteria:
inclusion criteria: * patients with de novo true bifurcation lesion (medina classification 1,1,1 or 0,1,1 or 1,0,1) * the main vessel diameter is least 2.5 mm and the side branch diameter is at least 2.25 mm exclusion criteria: * patients presenting with st segment elevation myocardial infarction, cardiogenic shock and killip class iii-iv heart failure * patients with a history of coronary artery bypass grafting surgery * patients with a chronic total occlusion in the bifurcation area * lesions with severe calcification that needs additional intervention such as atherectomy * patients who are not suitable to use long term dual antiplatelet therapy and patients not participating in clinical follow-up * patients with hematological disorders, malignancy, end stage renal (gfr\<30 ml/min) and hepatic failure * patients with active bleeding * pregnant women * patients with life-expectancy \< 1 year
effects of task-oriented training on visual-motor integration and upper limb function in children with down syndrome

Conditions: Down Syndrome

Summary: the condition known as down syndrome (ds) is caused by trisomy 21, or the presence of an extra copy of chromosome 21. ds is the most common survivable autosomal aneuploidy and one of the genetically complicated problem compatible with post-term human survival. based on current birth prevalence, the prevalence of ds is around 25%-40%. it is one of the most prevalent disease. visual-motor integration difficulties are common in children with ds, which affects their capacity to synchronize hand movements with vision. this may have an impact on adls like writing, eating, grooming. both delays in motor skills and visual processing might cause difficulties in this domain. this study will be a randomized controlled trial conducted in spectrum clinic. this study will be completed in time duration of 10 months after approval of synopsis. non-probability convenience sampling technique will be used and 28 participants will be recruited in study after randomization. informed consent will be taken from gradians then, the subjects will be divided into two groups and the group a (experimental group) will receive task-oriented training 3 times a week which focus on exercises that improve ul function and visual motor coordination and group b (control group) will receive general physiotherapy plan and game-based interventions. poor visual motor skills are one of the inclusion criteria, but significant intellectual disability, prior involvement in related interventions, and untreated medical or psychological conditions are among the exclusion criteria. the data will be assessed at the baseline and after 8th week of treatment. after data collection data will be analyzed by using spss version 23.


Eligibility criteria:
inclusion criteria: * • diagnosed down syndrome patient * both male and female * age range 5 to 12 * children who has poor vm skills exclusion criteria: * • sever intellectual disability * previous participation in similar interventions * uncontrolled medical or psychiatric conditions * low communication skills

Keywords: down's syndrome visual motor integration task-oriented training upper limb function
healing assessment of external inflammatory root resorption after revascularization technique of avulsed permanent central incisor (case study)

Conditions: Avulsion

Summary: evaluate the healing of external root resorption of replanted avulsed permanent maxillary central incisor after revascularization.

healing assessment of external inflammatory root resorption after revascularization technique of avulsed permanent central incisor (case study)

Eligibility criteria:
inclusion criteria: * traumatic teeth * external inflammatory root resorption exclusion criteria: -
multimodal ultrasound diagnosis characteristics of bi-rads class 4 breast lesions

Conditions: Breast Disease

Summary: objective: to explore the potential association between the multimodal ultrasound characteristics and pathological classification of bi-rads category 4 breast lesions, so as to clarify the diagnostic characteristics of multimodal ultrasound in different pathological types bi-rads category 4 breast lesions. materials and methods: patients who visited in the first affiliated hospital of shandong first medical university ＆ shandong provincial qianfoshan hospital were collected. their general clinical features, information on preoperative ultrasound diagnosis, and postoperative pathologic data were reviewed.


Eligibility criteria:
inclusion criteria: * perform ultrasound examination at our hospital before surgery or puncture biopsy; complete histopathological data; two ultrasound physicians with more than 5 years of experience in breast ultrasound diagnosis were diagnosed as bi-rads class 4 based on preoperative ultrasound images. exclusion criteria: * poor image quality; incomplete clinical data.
the effects of game-based exercises on balance, kinesiophobia, fatigue levels, and pain in sedentary individuals

Conditions: Sedentary Behavior

Summary: physical activity is a significant factor that greatly affects human health. however, with the development of technology, there has been a significant decrease in the physical activity levels of individuals in their daily lives, leading to the emergence of a sedentary society.

technological advancements, such as electronic devices and machines that replace human labor, push individuals toward laziness, encouraging them to adopt a more inactive lifestyle.

Eligibility criteria:
inclusion criteria * accepting to participate in the study * between the ages of 18 and 45 * physical activity level according to the international physical activity questionnaire (short form) between 600 met- 1500 met min/week * having an appropriate cognitive level (not having a cognitive level that would make it difficult to understand the study or to perform the exercise) exclusion criteria * physical activity level \>1500 met-min/week according to the international physical activity questionnaire (short form) * having cancer and malignant tumours * presence of cognitive problems * severe vision problems (colour blindness, blindness, etc.)

Keywords: pain exercise