Kornimate/medical-research-clean huggingface dataset:
effectiveness of pramipexole for treatment-resistant depression

Conditions: Depression

Summary: this study will evaluate the effectiveness of pramipexole (mirapex) in managing treatment-resistant depression.

depression is a serious medical illness, for which various types of treatment have been developed. both medications and therapies have proven effective in treating depression. however, some people with depression do not benefit from these treatments. new medications are needed for treating depression in those who have not responded to commonly used antidepressants. pramipexole (mirapex) is most often used for the treatment of parkinson's disease, but has been reported to have antidepressant effects as well. this study will evaluate the effectiveness of pramipexole in treating depression in individuals that have not responded to other medications. participants in this double blind study will be randomly assigned to receive either pramipexole or placebo, in addition to their current medications, for 8 weeks. treatment response will be assessed at the end of this phase by measuring symptoms of depression. at this time, those individuals who have responded to treatment will have the option to continue in a 6-month follow-up study. participants will be seen monthly throughout the 6 months to assess treatment response. participants who do not exhibit a response to treatment will be tapered off the medication. all participants will receive 3 months of follow-up care, regardless of their response to the medication.

Eligibility criteria:
inclusion criteria: * meets diagnostic criteria for major depressive disorder * meets criteria for current major depressive episode * score of at least 18 on the montgomery-asberg depression rating scale (madrs) at the baseline visit * currently being treated with antidepressant monotherapy at an adequate dose for 6 weeks or willing to enter open lead-in treatment * agrees to use an effective form of contraception throughout the study exclusion criteria: * pregnant * at risk for suicide or homicide * unstable medical illness (e.g., cardiovascular, liver, kidney, respiratory, endocrine, or neurologic disease, including uncontrolled seizure disorder) * history of a substance use disorder within 6 months of study enrollment * history of or current psychotic features * currently being treated with typical or atypical antipsychotic medications * currently being treated with a medication known to significantly decrease pramipexole clearance (e.g., cimetidine, ranitidine, diltazem, verapamil, quinine or triamterene) * clinical or laboratory evidence of untreated hypothyroidism * history of a 2-week or longer course of pramipexole * intolerance of pramipexole at any dose * any investigational psychotropic drug use within the last three months * level 3 or greater antidepressant resistance as assessed by the athf * three or more episodes of self-harm in the year prior to study enrollment * documented history of poor treatment adherence or frequently missed appointments * parkinson's disease

Keywords: depression, treatment-resistant
deportalization, venous deprivation, venous congestion

Conditions: Malignant Liver Tumor

Summary: patients with multiple primary or secondary liver tumors have a low survival rate unless they can benefit from curative extended hepatic resections with r0 or r1 marge resection. post-operative acute liver failure may occur after such surgery when the remnant liver is insufficient, leading to high morbimortality. the future remnant liver (frl) preoperative evaluation is then the key consideration before performing extended liver resection. the frl volume measurement on computed tomography (ct) imaging is the most widespread method of frl evaluation. threshold values of acceptable frl volume depend on the underlying liver function, it ranges from 20-30% in healthy liver to 40% in cirrhotic liver. however, it recently appeared that the frl function would be more valuable in predicting post-operative liver failure. 99mtc-mebrofenin hepatobiliary scintigraphy (hbs) combined with spect/ct enables reliable frl function measurement with a threshold value calculated at 2.69%/min/m2, to predict post-hepatectomy liver failure. when the frl evaluation does not reach the acceptable threshold values to avoid liver failure, portal vein embolization (pve), consisting of portal branches occlusion of the future removed liver, can be performed. it is now the standard of care to induce frl regeneration before surgery. right pve induces right hemiliver (s5-8) deportalization (portal input deprivation with hepatic venous drainage preservation) leading to left hemiliver (s2-4) regeneration. to optimize pve results, recent effective techniques have been developed such as the simultaneous embolization of the right portal branch and the right hepatic vein (hv), and the right accessory hv if so, which is called liver venous deprivation technique. additional simultaneous embolization of the middle hv defined the extended liver venous deprivation (elvd) technique. elvd induces right liver (s5-8) venous deprivation (deprivation of both portal input and venous drainage) and leads to rapid increase in frl function. after elvd, segment iv (s4) portal input from left portal branch is preserved while its venous drainage through the middle hv is disrupted, resulting in venous congestion. the aim of this study is to analyze the volumetric and functional evolutions after embolization procedures in deportalized liver (s5-8 after pve), vein-deprived liver (s5-8 after elvd) and congestive liver (s4 after elvd).


Eligibility criteria:
inclusion criteria: * age \> or = 18 years * primary or secondary liver tumor(s) * major hepatectomy approved by multidisciplinary tumor meeting * small frl (baseline flr \<2.69%/min/m2) exclusion criteria: * liver fibrosis / cirrhosis * biliary obstruction
cortical cerebellar infarctions associated with patent foramen ovale in young stroke patients

Conditions: Brain Infarction

Summary: the investigator retrospectively analyzed consecutive young (\<60 years) cryptogenic stroke patients with patient foramen ovale (pfo) recruited between january 2016 and may 2019 in our center, and compared these patients with sex- and age-matched controls with cryptogenic stroke without pfo. analyzed baseline characteristics: sex, age, cardiovascular risk factors, history of stroke, and cortical/subcortical localization, arterial territory, number of lesions, and lesion size of the acute symptomatic infarction, together with the rope score. the presence and the number of acute and chronic scci lesions were assessed.


Eligibility criteria:
inclusion criteria: * patients : young (\<60 years) adult patients, * patient recruited and registered in our stroke database between january 2016 and may 2016 of our center (nîmes university hospital, france), * patients presenting with an acute symptomatic infarction (confirmed by diffusion-weighted mri) of unknown origin * controls : age-matched controls with cryptogenic stroke without pfo
management of childhood obesity

Conditions: Childhood Obesity; Pediatric Obesity

Summary: the significant increase in the prevalence of obesity can also be attributed to various social changes, in which the environment (political, economic, social, cultural), and not only the individual and his choices, takes a strategic place in the analysis of the problem and proposed interventions. the food environment can influence the choice and consumption of foods that promote obesity, such as ultra-processed foods (upa). it is suggested that to intervene to effectively change behavior and eating habits, intensive interventions are needed that consider multiple levels that include the family, school, and community rather than one-off interventions that may not be effective in changing behavior and lifestyle. regarding the family environment, parents or guardians can assist in the adoption of obesity-related behavioral patterns. it is known that the context of primary health care (phc) is ideal for actions to prevent diseases and promote children's health, since the phc professional team is closest to the reality of life of the child, family, and community. we emphasize the importance of this study from the perspective of treatment of childhood obesity, in order to generate scientific evidence and practical subsidies for the implementation of interventions focused not only on the individual, but also in the context of the unified health system (sus). the hypothesis of the study is that there will be a decrease in the consumption of ultra-processed foods (upa) among children, aged 6 to 10 years, living with obesity and who are treated in primary health care. in addition to encouraging healthy habits such as physical activity and the consumption of in natura and minimally processed foods. the management of childhood obesity is one of the priority topics on the national agenda of sus's food, nutrition, and health promotion policies.


Eligibility criteria:
inclusion criteria: * child classified as obesity by values equal to or greater than z-score +2 for bmi/age exclusion criteria: * children with severe mental disorders * children on weight loss medication and with comorbidities associated with obesity * children participating in any diet and physical activity program for weight loss/maintenance * parents/guardians who do not agree to participate and do not sign the informed consent form
cocrmo lock bipolar femoral heads fu

Conditions: Femoral Fractures; Hip Arthropathy

Summary: study design: monocentric, retrospective, observational and post-market clinical study. purpose: to demonstrate the safety and performance of cocrmo lock bipolar femoral heads. the eligible study population is represented by the entire population that underwent a hip replacement with cocrmo lock bipolar femoral heads from 1st january 2023 onwards at the site in accordance with the indication for use of the product.

the study is aiming to demoranstrate safety and performance of lock bipolar femoral heads and will do it by considering the rate of revision of any prosthesis component and dislocation, by x-ray evaluation, by patient reported outcomes and walking/residential status. patients are followed for 2 years after hemiarthroplasty and data are collected at 6 timepoints (pre-operative, intra-operative, at discharge, 4-months follow up, 12 months follow up and 24 months follow up).

Eligibility criteria:
inclusion criteria: * displaced intracapsular hip fracture (garden iii-iv). * subjects underwent a bipolar hemiarthroplasty with a cocrmo lock bipolar femoral head as per their indication for use from january 1st, 2023, onwards. * no concurrent joint disease at the time of the surgery. * absence of severe cognitive dysfunction demonstrated by 3 or more correct answers on the pfeiffer test. * ability to ambulate independently with or without walking aids before surgery. * subject willingness to participate. exclusion criteria: * undisplaced or minimally displaced intracapsular hip fracture (garden i-ii). * any cocrmo lock bipolar femoral head contraindication for use as reported in the current instruction for use. * pathological fracture secondary to malignant disease. * subjects with rheumatoid arthritis or symptomatic osteoarthritis. * previous treatment to the same hip for a fracture at the time of the surgery. * subjects who were deemed unsuitable for the surgical procedures by the anesthesiologist. * severe cognitive dysfunction or cognitive impairment demonstrated by 2 or less correct answers on the pfeiffer test. * unable to walk before surgery (e.g., wheelchair or bed-ridden subjects).

Keywords: femoral head partial hip arthroplasty
prevalence of obesity and overweight in primary school children in the rhein-neckar region in germany

Conditions: Overweight, Childhood; Obesity, Childhood; Child Development; Overweight and Obesity; Underweight

Summary: the study will determine the weight status in primary school children in the rhein-neckar region in germany and will analyse the development of height and weight in these children during the time of covid-19 related restrictions by asking parents to provide data from childhood examinations. additionally, interactions between cognitive abilities and weight-status will be studied.

the prevalence of obesity and overweight is increasing among both adults and children. school and kindergarten closings during the covid-19 epidemic may have had an additional negative impact on the weight development of the affected children. this study aims to examine the post-lockdown prevalence of overweight and obesity in school children in the second grade in the rhein-neckar region in germany and look at possible lockdown effects. additionally, interactions between cognitive abilities and weight-status will be studied. anthropometric measurements, interviews as well as cognitive testing will be performed in schools in the summer of 2021 in children in the first grade (class 2020/2021). parents will be asked to provide measurements from u-childhood-examinations and complete a 3-day food record. the local health authority (gesundheitsamt) will assist in making a representative selection of schools from different socioeconomic areas and provide data from the pre-school examinations. collected data will be analyzed and compared to national and international surveys, evaluating the trends of the children's height and weight development. weight status will be assessed by calculating z-bmi standardized for age and compared with national and international growth charts using both national and who classification. potential interrelation between weight-status, weight development with cognitive performance will be explored. the study will be able to deliver valuable insights in regards to the health of school children in the rhein-neckar region as well as evaluate the effect of covid-19 related lockdowns on their health.

Eligibility criteria:
inclusion criteria: * written consent from parents and or guardians exclusion criteria: * missing consent of parents or guardians

Keywords: overweight obesity children cognitive function cognitive function and weight status
trial of unicompartmental versus total knee arthroplasty

Conditions: Osteo Arthritis Knee

Summary: this study is a prospective, randomized trial to compare patient outcomes of unicompartmental knee arthroplasty (uka) and total knee arthroplasty (tka) for the treatment of medial compartment osteoarthritis.


Eligibility criteria:
inclusion criteria: * medial compartment osteoarthritis of the knee * knee flexion greater than greater than 90 degrees * flexion contracture of less than 10 degrees * varus deformity \< 20 degrees * grade iv degeneration of the medial compartment exclusion criteria: * lateral compartment degenerative changes * previous lateral meniscectomy * anterior cruciate ligament deficiency * body mass index \> 40 * inflammatory arthritis * history of septic arthritis * hemoglobin a1c \> 8.0 * chronic liver disease * stage 3a or greater chronic renal disease * active iv drug abuse * patients requiring thromboembolic prophylaxis

Keywords: unicompartmental knee total knee arthroplasty osteoarthritis
comparison of outcomes with stapler versus hand-sewn closure after minimally invasive distal pancreatectomy

Conditions: Distal Pancreatectomy; Postoperative Pancreatic Fistula

Summary: the incidence of postoperative pancreatic fistula (popf) after distal pancreatectomy (dp) remains high. of the available mitigation strategies, high-quality closure of the pancreatic stump is fundamental. researchers failed to find a decrease in the incidence of popf after stapler closure of the pancreatic stump compared with that related to hand-sewn suture in dp. minimally invasive dp (mdp) is becoming the first choice for patients and surgeons, few studies have evaluated whether stapler closure is superior to hand-sewn suture for stump closure in mdp. therefore, this retrospective study was aimed at evaluating the effect of stapler versus hand-sewn closure on the incidence of popf after mdp.


Eligibility criteria:
inclusion criteria: * underwent elective minimally invasive pancreatic body and tail resection with or without splenectomy exclusion criteria: * incomplete medical records * history of previous pancreatic operations * emergent operation * conversion to open pancreatectomy * receipt of wedge resection or other procedures
degradation of the anorexic hormone peptide yy

Conditions: Healthy

Summary: peptide yy (pyy) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. the n-terminal truncated form, pyy3-36, exerts anorexic effects. in this study we want to investigate the kinetics of pyy1-36 and pyy3-36 and to examine whether a c-terminally degraded metabolite, pyy3-34, is formed after infusion of pyy.


Eligibility criteria:
inclusion criteria: * healthy * normal bmi (18.5-25kg/m2) exclusion criteria: * diabetes mellitus * gastric bypass * non-caucasian * height changes \>3 kg within last two months * hemoglobin \< 7.6 mmol/l * chronic disease * smoking * regularly use of medicine * drug abuse

Keywords: pyy degradation kinetics men
text2breathe: enhance parent communication to reduce pediatric asthma disparities

Conditions: Asthma

Summary: text2breathe (t2b) is a randomized controlled trial aimed at improving communication between parents and their children's' primary care providers about asthma. the overarching goal of this study is to reduce disparities among a population with high rates of pediatric asthma morbidity. the investigators are testing the efficacy of a short message service (sms)-enhanced health communication (hc) intervention ("text2breathe") designed to equip urban, low-income parents with tools for communicating effectively with their children's primary care provider (pcp).

potentially eligible participants are approached and screened in person during an admission of their child to the emergency department for asthma care. those participants randomized to the intervention will receive additional education on effective communication with their child's primary care provider (pcp). these participants will also receive educational text messages for three months after their initial visit. text messages will include education on effectively communicating with their child's provider and general asthma information. both the control group and intervention group will receive text message reminders to schedule regular follow up visits with their pcp and get an annual flu shot. both groups will be contacted for follow up phone interviews at 3, 6, 12, 18 and 24 months.

Eligibility criteria:
inclusion criteria: * unlimited text messaging is the parent of child who is: * receiving asthma related care in the emergency department * 2-12 years old inclusive * medicaid insured (no private insurance) * physician diagnosed asthma for at least 12 months exclusion criteria: is the parent of child who: * has seen a pulmonary or allergy sub-specialist more than once in the last 6 months * has seen a sub-specialist (not pulmonary or allergy) more than once in the last 12 months * has been hospitalized for more than 30 days * is currently enrolled in another asthma program or study
effect of honey and dexamethason on extraction healing

Conditions: Impacted Third Molar Tooth

Summary: natural honey and dexamethason will be given before impaction removal then postoperative complications will be evaluated

patient with impacted lower third molar will be selected to this study agording to agent applied preoperative. group 1 will receive topical honey and group 2 will receive iv dexamethason. after surgical removal of impacted tooth under local anesthesia postoperative pain mouth opening, and swelling will be evaluated

Eligibility criteria:
inclusion criteria: * impacted 3rd molar * healthy patient no smoking exclusion criteria: * history of smoking medical disease
relationship of staphylococcal colonization to infection

Conditions: MRSA Infection

Summary: inpatients will be prospectively have nares screened and mrsa strains collected. all clinical mrsa strains of patients will also be prospectively collected. a sensitive strain discrimination test of spa typing will be used to determine if the strains are related. hypotheses are 1. strain colonization durations vary and may be very short in days to weeks. 2. colonizing strains rarely infect 3) both 1 and 2 may be affected by the patient's co-morbidity.

patients of special interest: 1. skin and soft tissue infection 2. nursing home patients 3. vascular patients with leg lesions 4. icu patients 5. hemodialysis patients 6. outpatients without history of infections(controls) will have nares screened for mrsa and then monthly for 1 year. all strains will be saved and spa typed. analysis of the data will be performed to answer the questions and hypotheses and to answer is the screening effort and the isolation of patients for mrsa as is in current practice worthwhile and is there any scientific data to support this practice

Eligibility criteria:
inclusion criteria: * admitted and one of the co-morbid groups * ambulatory care patient with no infections exclusion criteria: * all others

Keywords: methicillin-resistant staphylococcus colonization
dry needling, manual therapy and exercise for neck pain management

Conditions: Neck Pain, Posterior

Summary: since neck pain is the fourth highest disabling condition (with an estimated point prevalence of 20%, lifetime prevalence up to 70% and high recurrence rates), dry needling targeting myofascial trigger points in neck muscles has been proposed as an effective treatment for reducing pain and disability in patients with chronic neck pain. a recent meta-analysis reported whether dry needling could be recommended for this population. low to moderate evidence suggests that dry needling can be effective at the short-term, but its effects on pressure pain sensitivity or cervical range of motion are limited.


Eligibility criteria:
inclusion criteria: * to be between 18 and 65 years old * to have been experiencing unilateral neck pain for at least 3 months * to have a neck disability index (ndi) score \>8 * to have a visual analogue scale (vas) score \>3 * to have at least one active mtrp located in the upper trapezius or cervical multifidus muscles exclusion criteria: * history of whiplash injury * previous cervical surgery * cervical radiculopathy or myelopathy * diagnosis of fibromyalgia * additional analgesic treatments during the study (e.g. physiotherapy or drugs) * psychiatric disorders * any contraindication to the interventions proposed (e.g. fear of needles or anticoagulants)

Keywords: dry needling