Kornimate/medical-research-clean huggingface dataset:
yoga improves aerobic fitness, glycemia and mood state and reduces abdominal obesity

Conditions: Obesity; Insulin Resistance

Summary: stretching and flexibility exercise such as yoga and functional resistance exercise are two forms of exercise that are growing in popularity. however, they have not been scientifically tested to demonstrate their ability to improve body composition, fitness, heart and metabolic health, and mood state in overweight/obese women. the investigators hypothesize that during an 11 week intervention, both forms of exercise will improve body composition, heart and metabolic health and mood state.

this study was a 11 week protein-rich whole food diet and exercise training intervention in middle aged overweight/obese women. subjects were randomized into 3 groups: protein-rich whole food only consumed as 20-25 grams per serving 4-6 per day (p); protein and resistance exercise training (r); and protein and stretching/yoga exercise training (s). all outcomes, including the primary outcomes of body composition and cardiometabolic biomarkers were measured at baseline (week 0) and post-intervention (week 12) in all study subjects.

Eligibility criteria:
inclusion criteria: * obese or overweight women * between ages 25-60 and * otherwise healthy exclusion criteria: * smokers, * habitual exercisers

Keywords: obesity protein-rich whole foods diet aerobic fitness resistance training stretching/yoga training glycemia mood state
sglt2 inhibitors and effects on hematopoiesis, inflammation and metabolic markers

Conditions: Diabetes Mellitus, Type 2

Summary: study of the response to sglt2 inhibitors in type 2 diabetic patients with relevance to the erythropoesis and indexes of cardiorenal function. the study enrolls type 2 diabetic patients in whom the introduction of a sglt2 inhibitor is deemed necessary as part of their routine treatment during their visit to our outpatient diabetes unit. a whole blood, a serum and a urine sample is obtained before and one month after the initiation of treatment with a sglt2 inhibitor.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * hba1c\>7% on their current treatment * introduction of sglt2 inhibitor as part of their routine care exclusion criteria: * egfr\<60 ml/min

Keywords: sglt2 inhibitors, hemoglobin, ntprobnp, ketones
comparison of different locations for pulse oximetry probes in cardiovascular (cv) patients with poor peripheral perfusion

Conditions: Congestive Heart Failure; Cardiomyopathy

Summary: the purpose of this study is to determine if the forehand location for sensor placement has less episodes of signal dropout than the finger sensor location. in addition, this study will evaluate two finger sensors, which utilize different technology to compare signal quality.

a comparison study design will be used to evaluate the signal quality of pulse oximetry sensors placed in two locations: forehand and finger. each subject will serve as their own control, with measurements of signal quality evaluated at 2 second intervals over a period of one hour. the measurements will be recorded simultaneously with a computer program and laptop computer. finger and forehand sensors will be applied according to manufacturer's guidelines. an output connection will be made from each pulse oximeter computer unit to a password protected, laptop computer for data downloading. data will be collected for a 1 hour period at 2 second increments and stored in the hard drive of the laptop. following completion of data collection, the study sensors will be removed.

Eligibility criteria:
inclusion criteria: * cicu patients with a new diagnosis or history of chf or cardiomyopathy * patients with a medical order for pulse oximetry monitoring * age greater than or equal to 18 years of age * english speaking * signs of hypoperfusion exclusion criteria: * cicu patients with an impediment to sensor application * cicu patients with excessive facial edema * cicu patients with mechanical ventilation * cicu patients with intra-aortic balloon pump therapy * cicu patients with intravenous vasopressor drug administration

Keywords: congestive heart failure cardiomyopathy
intra-arterial chemotherapy for children with retinoblastoma

Conditions: Retinoblastoma

Summary: retinoblastoma is a cancer of the eye that occurs exclusively in children. the treatment for retinoblastoma may include surgery, chemotherapy, radiation and local treatments to the eye such as freezing (cryotherapy) and local radiation (brachytherapy). in some cases, a child with retinoblastoma will have active cancer in a single remaining eye with useful vision. in such cases, it is sometimes necessary to remove this eye. in such cases, the injection of chemotherapy directly into the artery that supplies the eye and the tumor may lead to regression of the tumor without the need to remove the eye. this form of treatment was pioneered by a group in new york (abramson et al). in this study the investigators will assess the efficacy and safety of the technique in a group of children with retinoblastoma.


Eligibility criteria:
inclusion criteria: * children with retinoblastoma in a single remaining eye with useful vision exclusion criteria: * none

Keywords: retinoblastoma
phase ii study of zio-101 in advanced blood and bone marrow cancers

Conditions: Hematologic Neoplasms; Bone Marrow Neoplasms; Non-Hodgkin's Lymphoma

Summary: the study of safety of a new organic arsenic compound in the treatment of hematological malignancies.


Eligibility criteria:
inclusion criteria 1. hodgkin's or non-hodgkin's lymphoma. 2. ≥ 1 prior therapy and currently requiring therapy. 3. evaluable disease (defined by disease-specific criteria listed in appendix 1) 4. ≥ 18 years of age. 5. ecog performance score ≤ 2 (see appendix 2). 6. life-expectancy ≥ 2 months. 7. written informed consent in compliance with ziopharm policies and the human investigation review committee with jurisdiction over the site. 8. no anti-cancer therapy exception of hydroxyurea ≤ 3 weeks before baseline (day 1, cycle 1). 9. the following clinical laboratory values \< 2 weeks before baseline: * creatinine ≤ 2x upper limit of normal (uln). * total bilirubin ≤ 2x uln. * alanine transaminase (alt) and aspartate transaminase (ast) ≤ 3x uln. exclusion criteria 1. new york heart association (nyha) functional class ≥3 myocardial infarction (see appendix ) within 6 months before baseline or uncontrolled cardiac arrhythmia other than asymptomatic atrial fibrillation; a qtc ≥450 msec; or a ≥grade-2 atrioventricular (av) block or left bundle branch block (lbbb). 2. pregnant and/or lactating female. (women of childbearing age must use effective contraception from screening through the duration of study participation). 3. uncontrolled infection. 4. prior seizures ≥ grade-3 in ctc v.3 criteria. 5. arsenic allergy. 6. significant neuropathology, defined as grade \> 2 per ctcae version 3.0. 7. confusion or dementia. 8. prior history of neurological deficits (e.g., stroke, dementia, ischemia) that has the potential to confound a post-dose neurological assessment.

Keywords: apl lymphoma t-cell lymphoma peripheral t-cell lymphoma
text messaging plus motivational interviewing in promotion of breastfeeding among hiv-infected women

Conditions: HIV Infections; Breast Feeding

Summary: the primary aim of this study is to find out whether it is feasible to conduct a larger study looking at the effect of mobile phone text messaging added to motivational interviewing on number of participants invited to the study who consented to participate and the number with complete evaluation of infant feeding practices at all study visits. secondary aim: in hiv-infected women initiating breastfeeding after giving birth, does interactive weekly mobile phone text messaging plus motivational interviewing versus usual care, improve self-reported adherence to exclusive or any breastfeeding 6 months post-delivery and to determine the number of women remaining in the group they were assigned until end of study or lost to follow-up (protocol adherence).

breastfeeding reduces the risks of dying from infections and is currently recommended as the most beneficial feeding option for infants born to hiv-infected women in low-resourced settings. this recommendation contradicts previous recommendations to avoid breastfeeding to prevent mother-to-child transmission of hiv. south africa, a high hiv prevalent country, recently phased out access to free formula milk in the public sector in support of breastfeeding for hiv-infected women. the investigators previously found that few hiv-infected south african women choose breastfeeding and among those who did, many stop breastfeeding early. this study involves text messaging breastfeeding advice encouraging women to exclusively breastfeed, and inquire if they have any breastfeeding related problems, and motivational interviews exploring and supporting woman's commitment to continue breastfeeding.participants meeting inclusion criteria who consent participation will be enrolled by a research nurse and immediately randomly assigned to text messaging plus motivational interviewing group or usual standard of care group. the investigators propose a randomized, parallel group, standard of care-controlled pilot trial which will be conducted among hiv-infected women of low socio-economic background, giving birth at a primary healthcare clinic in cape town, south africa. the pilot trial will assess the feasibility of conducting a larger trial on communication and support approaches that may improve hiv-infected woman's adherence to exclusive and continued breastfeeding.

Eligibility criteria:
inclusion criteria: * women living with hiv * initiated breastfeeding within 24 hours of giving normal birth * on art * 18 years or older * ownership of a mobile phone * infants judged to be in good health who are discharged soon after delivery exclusion criteria: * initiating both breastfeeding and formula feeding or formula feeding within 24 hours of giving birth. * gave birth to more than one infant * birth weight \< 2500 * gestational age \< 36 weeks

Keywords: hiv infant feeding mhealth behavioural intervention
mesenteric ischemia in the emergency department: a retrospective multicenter study

Conditions: Acute Mesenteric Ischemia

Summary: acute mesenteric ischemia is a life-threatening condition characterized by high mortality if unrecognized early. this multicenter retrospective observational study will review the emergency departments's (ed) notes of all patients discharged from hospital with a diagnosis of acute mesenteric ischemia in 2014-2015 comparing it with those admitted to the ed for abdominal pain in the same timeframe.

acute mesenteric ischemia is a condition characterized by non-specific presentation (typical clinical presentation is considered "abdominal pain out of proportion to examination") that may be under-recognized in the emergency department. early identification and treatment is essential to improve outcome as mortality rate is attested around 80% if untreated within few hours from onset. the investigators aim to review the emergency department's clinical notes of patients discharged from hospital in 2014 and 2015 diagnosed with acute mesenteric ischemia. furthermore the investigators will consider patients admitted for "abdominal pain" in the same time frame without acute mesenteric ischemia and we will compare presentation symptoms, medical history, medications, vitals, laboratory markers and imaging finding of the two groups. from this comparison, the investigators will be able to clarify the incidence among general population and among patients presenting acute abdominal pain. finally, using multivariate analysis, the investigators may identify those variables predictive of acute mesenteric ischemia. this study will be held in three university hospitals and all data analyzed together.

Eligibility criteria:
inclusion criteria: * icd-9 diagnosis of acute mesenteric ischemia in 2014 and 2015 * admitted to hospital after emergency department assessment * age\>18 exclusion criteria: * age\<18 * post-traumatic or post-surgery related acute mesenteric ischemia * lack of assessment in the emergency department
evaluation and neural basis of communication in patients with multiple sclerosis

Conditions: Multiple Sclerosis; Social Cognition; Neuropsychology; Psychological Therory; Theory of Mind

Summary: multiple sclerosis (ms) progressively leads to an increasing level of disability. that's why individuals faced with this chronic disease whose progression is unpredictable have to mobilize all their available resources. as a result, management of interpersonal relationships appears to be a key issue in adjustment to situations. although knowledge on cognitive abnormalities in ms has been growing in recent years, there is a lack of research about social behaviour regulation skills. the few studies conducted in this field are mainly interested in emotional processing (emotional facial recognition and empathy) and skills mentalizing (theory of mind) that appear disturbed in ms. while some recent studies touch on the issue of the contextual analysis of language (that is to say, the social use of language) in ms, their assessment on a wide range of pragamtic skills has never been studied. however, the pragmatic aspects of language are known to play a major role in social adjustment. this project has three main objectives : (1) to increase general knowledge of deficits in communication and in social cognition in patients with ms, (2) to propose new leads for the evaluation of these disorders and (3) to contribute to increasing knowledge of neural basis of communication and social cognition. in order to address those objectives, the assessment will be focused on many various pragmatics skills : conversation, indirect language comprehension (indirect questions, idiomatic expressions, sarcasm) and metapragmatic knowledge in a population of 40 rr-ms patients. those patients' performances will be compared to a group of healthy matched control subjects, potential relationships between pragmatic abilities, other aspects of social cognition (theory of mind and processing of emotional stimuli), cognitive functioning, psycho-behavioural aspects and the characteristics of the disease will be explore. social cognition tasks have been selected for their dynamic and ecologic aspects in order to match natural social interaction. finally, communication consideration, cognitive and cerebral skills of patients with ms will contribute to increasing knowledge of the neural basis of social cognition.


Eligibility criteria:
inclusion criteria: exclusion criteria: * relapsing-remitting form as defined by the mc donald's committee criteria (2005). * edss between 0 and 5.5, out of relapses * french mother tongue or having been schooled in france * no disorders of formal language comprehension * not having participated to a similar protocol within the 9 months preceding the inclusion
nausea and vomiting in children receiving chemotherapeautic monotherapy

Conditions: Acute Leukemia

Summary: chemotherapy induced nausea is a common side effect for children undergoing chemotherapy. furthermore, chemotherapy-induced vomiting is a major factor limiting quality of life during treatment reported by paediatric cancer survivors. complete prevention of both nausea and vomiting is the goal of anti-vomiting and nausea medications. it is important to understand whether or not certain chemotherapeutic treatments are more or less likely to cause these symptoms. acute leukemia is the most common cancer diagnosed in children. intrathecal methotrexate is an important part of chemotherapy for the prevention and treatment of central nervous system leukemia over the 2.5 to 3.5 years of the treatment program for leukemia. the likelihood that intrathecal methotrexate administered as monotherapy will cause nausea and vomiting has not yet been described in children. knowledge of the likelihood that intrathecal methotrexate will cause nausea and vomiting will therefore be important to optimize treatment for these side-effects of chemotherapy. the primary aim of this prospective study is to evaluate the potential of intrathecal methotrexate to cause nausea and vomiting in paediatric cancer patients.


Eligibility criteria:
inclusion criteria: * 4 years old to 18 years of age (age range in which the penat has been validated) \[18\] * english speaking (penat has been validated only in english) * cognitive ability of the child believed to be at least at a 4 year old level according to parent or health care professional * patients are past their first cycle of maintenance therapy to avoid interactions with the intensive chemotherapy phase. exclusion criteria: * receiving chemotherapy other than dictated by protocol for maintenance therapy within 24 hours prior to or 24 hours following receipt of intrathecal methotrexate

Keywords: acute leukemia pediatrics intrathecal methotrexate chemotherapy nausea vomiting
cross-linked hyaluronic acid/dextranomer for the treatment of stress urinary incontinence

Conditions: Urinary Stress Incontinence (SI)

Summary: the investigators aimed to evaluate the effectiveness and safety of intraurethral cross-linked hyaluronic acid/dextranomer (clha/dx) injection for the treatment of stress urinary incontinence (sui) in women.

this single-center prospective pre-post interventional study was conducted between october 2025 and april 2025 with 60 women . quality of life was evaluated with the incontinence quality of life scale (i-qol) and the lower urinary tract symptoms of women were evaluated with the international consultation on incontinence questionnaire female lower urinary tract symptoms modules (iciq-fluts). incontinence status was assessed via the stamey incontinence grade scale. the need for additional treatment (re-injection, other surgical approaches, etc.) was recorded. participants were followed up to 6 months after intervention. all outcomes of interest and complications were evaluated/recorded at three preplanned visits (postoperative 1st, 3rd, 6th, months).

Eligibility criteria:
inclusion criteria: * diagnosis of stress urinary incontinence. * presence of incontinence during the valsalva maneuver. * positive marshall-marchetti test result. * post-void residual urine volume of ≤100 ml. exclusion criteria: * temporary urinary incontinence. * delirium. * urinary tract infection. * urethritis. * pure urge incontinence. * nocturnal enuresis. * decreased bladder compliance or detrusor contraction observed in urodynamic -studies. * leakage of urine with low bladder pressure. * psychiatric conditions (severe depression and anxiety). * body mass index (bmi) \&gt; 35 kg/m². * use of medications that may influence bladder storage or emptying.

Keywords: cross-linked hyaluronic acid/dextranomer mid-urethral sling female stress urinary incontinence
study of the ani validity on evaluation of nociception in state of hypnosis

Conditions: Healthy

Summary: healthy subjects should assess pain on a numerical scale (en), during painful skin stimuli of variable intensity delivered by a co2 laser used at the power of 0.3 w, known for its safety. ani (analgesia nociception index) will be raised simultaneously. this sequence will be made on subjects at rest and in a state of hypnosis using the technique of "remembering a pleasant memory" and the ideo-sensory technique of "protective glove". the average value of the ani will be compared to the value of the evn of pain intensity.


Eligibility criteria:
inclusion criteria: * knowledge of the state of hypnosis * healthy volunteers * capable adults * free and informed consent exclusion criteria: * heart diseases * medication affecting the heart rate * medication affecting the skin sensitivity

Keywords: healthy volunteers critical awareness hypnosis analgesia nociception index numerical verbal scale determine the validity of the index (ani) nociception in critical awareness
gaze holding in cerebellar patients

Conditions: Gaze Holding in Humans; Rebound in Humans

Summary: the long-term goal of this research is to advance the investigators knowledge of how the cerebellum a) controls gaze holding and compensates for impaired gaze stability and b) modulates vestibular information that is forward-ed from the labyrinth and brought to perception. while gaze holding is stable also at large angles of gaze eccentricity in healthy human subjects, patients with chronic (degenerative) cerebellar disorders are inable to stabilize gaze in eccentric positions, resulting in eye drift towards primary (straight-ahead) position and com-pensatory gaze-evoked nystagmus. when returning to primary position, a compensatory nystagmus into the opposite direction (called rebound nystagmus) can be observed in these patients. unlike patients with de-generative cerebellar disorders, patients suffering from ischemic of hemorrhagic stroke within the cerebellum present with acute deficits of gaze holding and verticality perception. while a linear relationship between the amount of eye velocity drift and eccentricity of eye position has been proposed in healthy human subjects, others suggested non-linear behaviour. the strategy of this research is to characterize gaze holding and verticality perception in healthy human subjects and patients with either acute (ischemic or hemorrhagic) or chronic degenerative cerebellar disorders and to relate eye movement findings with structural imaging of the cerebellum. the investigators will therefore analyze key cerebellar structures with regards to loss of volume and relate these imaging findings with the participants' ability to hold gaze and es-timate direction of vertical. the investigators hypothesize that besides the flocculus other vestibulo-cerebellar structures are involved in gaze holding and verticality perception in humans.


Eligibility criteria:
inclusion criteria: 1. ages 18-85 2. informed consent 3. for group 1: acute (i.e. symptom onset \<14 days ago) cerebellar ischemia or hemorrhage as confirmed by clinical examination and brain imaging (ct or mri) 4. for group 2: chronic cerebellar degeneration as confirmed by clinical examination (presence of downbeat-nystagmus and / or gaze-evoked nystagmus and / or ataxia of gait and stance) in the absence of focal lesions (as previous cerebellar stroke, mass lesion or inflammation) on clinical routine cerebellar imaging 5. absence of exclusion criteria exclusion criteria: 1. has mri contraindications such as pacemaker, implanted pumps, shrapnel, etc. (full mri screening form will be filled out). 2. disturbed consciousness 3. other neurological or systemic disorder which can cause dementia or cognitive dysfunction 4. pregnancy or possible pregnancy if not ruled out by a negative pregnancy test.