Kornimate/medical-research-clean huggingface dataset:
an observational study for evaluation of for the prevalence of cerebrotendinous xanthomatosis (ctx) disease

Conditions: CTX - Cerebrotendinous Xanthomatosis

Summary: the prevalence of ctx in our country is estimated to be 1 / 50.000. the aim of this study is to screen more volunteers by conducting a larger screening from neurology and pediatric metabolism clinics in turkey. this observational study was designed retrospectively and prospectively in two stages. in the retrospective section, the patient database and / or patient files will be screened in the neurology and pediatric metabolism clinics and the patients aged 40 and below in the neurology clinics with at least two of the following will be enrolled to the study: * ataxia and / or spasticity * bilateral cataract (except senile cataract) * intellectual limitation * non-enhancing hyperintensity on t2 sections in mr imaging of dentate nuclei * autosomal recessive transition pattern. (ex: relative marriage) in the pediatric metabolism centers, cases suspected of ctx and planned to apply the mignarri index according to the investigator's opinion will be identified.


Eligibility criteria:
inclusion criteria: i-1. giving written informed consent i-2. patients in neurology clinics should have been identified with at least two of the following: * ataxia and / or spasticity * bilateral cataract (except senile cataract) * intellectual limitation * nonintensitive hyperintensity in t2 sections on mri of the dentate nucleus * forming an autosomal recessive transition pattern. (ex: relative marriage) i-3. in the pediatric metabolism centers, cases suspected of ctx and planned to apply the mignarri index according to the investigator's opinion. i-4. on the day the patient signed the informed consent form, the patient did not get older than 41 years of age (subjects aged 40 and under will be included in the study) exclusion criteria: e-1. the patient's ataxia and / or spasticity, cataract, intellectual limitation, and non-contrasted hyperintensity of t2 sections in mr imaging of dentate nuclei with typical mri findings are due to a known cause other than ctx or other underlying disease. e-2. the patient has participated in an interventional clinical study in the last 30 days, e-3. the patient and / or his / her legal representative does not give consent to participate in the study, e-4. in the opinion of the investigator, the patient is not able to fulfill the working requirements appropriately, e-5. pregnancy and / or lactation e-6. if the patient was 41 years old when included in the study.
use of a biological lens of amniotic membrane (lv-visio-amtrix) in the treatment of treatment-resistant keratitis

Conditions: Keratitis

Summary: the purpose of this open, mono center trial is to assess the impact of the use of an amniotic membrane on the healing of a keratitis resistant to medical treatment.


Eligibility criteria:
inclusion criteria: * male or female; age between 18 and 65 years. * patient with non-infectious keratitis resistant to medical treatment for more than 15 days or recurrent after healing treatment. * patient with quantitative and qualitative score for inflammatory ocular signs \> 20. * patient with oxford grade \> 2. * informed and consenting patient with a relative or friend available to instill eye drops if necessary. * patient affiliated to a social security system or beneficiary of such a system. exclusion criteria: * patient with active infectious keratitis (bacterial, parasitic or viral). * patient with allergy to oxybuprocaine or tetracaine eye drops, to ester type local anesthetics and to fluorescein. * current contact lens wear, including scleral lenses. * nsaid eye drops and any drops containing preservatives. * antibiotic, anti-viral, anti-parasitic eye drops. * patient with identified causes for the keratitis for which discontinuation of medical treatment beneficial. * ocular surgery in the 3 months preceding the inclusion in the study. * monophtalmic patient. * person deprived of liberty by a judicial or administrative decision. * adult subjected to a legal protection measure or unable to express his/her consent.
open uncontrolled validation study for the german version of the actinic keratosis quality of life questionnaire (akqol)

Conditions: Actinic Keratosis

Summary: the objective of this study is to translate the "akqol"-questionnaire which measures the quality of life of patients with actinic keratosis into german and to validate it for the swiss population. by using the technique of cognitive interviewing the investigators are focussing on the patients' understanding of the questions. the first session of cognitive interviews will show, where there is need for improvement in terms of misinterpreted phrases or vaguely worded questions. the goal is to rephrase the questions according to the feedback of the patients. the revised version will then be presented to a new population.

actinic keratosis is a uv-induced skin disease, which presents as a reddish, squamous and sometimes itchy lesion. actinic keratosis seems to have a negative impact on patients' quality of life. esmann et al. elaborated on patients with actinic keratosis from zealand, denmark a questionnaire which measures the quality of life. the objective of this study is to translate this questionnaire into german and to validate it for the swiss population. this questionnaire might become part of a planned national register for data collection of patients with ak. the investigators will assess the content validity of the questionnaire by using the technique of cognitive interviewing. the investigators are going to talk 34 patients with ak from the department of dermatology, university hospital zurich through the translated version. thereby, the investigators are focusing on the patients' understanding of the questions. the first session of cognitive interviews will show, where there is need for improvement in terms of misinterpreted phrases or vaguely worded questions. the goal is to rephrase the questions in the sense that they become more clear and are understood by different interviewee in the same way. the revised version will then be presented to a new population. the performance of cognitive interview sessions and revisions will continue until the survey will be approved by at least 80% of the respondents.

Eligibility criteria:
inclusion criteria: * patients with actinic keratosis of the department of dermatology, university hospital zurich * male and female subjects \> 18 years of age * good understanding of written and spoken german * sufficient physical and mental capacity to comprehend the questions * written informed consent by the participant exclusion criteria: * lack of informed consent
untersuchung zur erfassung und kontrolle der lebensqualität unter einer therapie mit pollinex quattro bei heuschnupfen

Conditions: Rhinitis, Allergic, Seasonal

Summary: questionnaire to measure and control the quality of life of patients with hay fever who are treated or were treated with pollinex quattro

questionnaire including 19 questions concerning the quality of life of patients with hayfeyer under or after therapy with a specific immuntherapy with pollinex quattro

Eligibility criteria:
inclusion criteria: * pollinosis/seasonal rhinitis based on an allergy against birch/alder/hazel pollen or grass/rye pollen or mugwort * therapy with polinex quattro exclusion criteria: * age \<18 years.

Keywords: pollinosis, quality of life, specific immunotherapy
fecal microbiota transplantation for radiation enteritis

Conditions: Radiation Enteritis

Summary: radiation enteritis is one of the most feared complications after abdominal or pelvic radiation therapy.the gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body metabolism. evidence from animal studies demonstrated the link between intestinal bacteria and radiation enteritis. this clinical trial aims to evaluate the efficacy and safety of fecal microbiota transplantation (fmt) for radiation enteritis.

the present clinical trial aims to re-establish a gut functionality state of intestinal microbiota through fecal microbiota transplantation (fmt) for radiation enteritis (re). fmt is the whole profile of fecal microbiota transplantation. at enrollment, "shared decision making" intervention was applied to support patient involvement in making health decisions. patients have opportunity to choose fecal microbiota transplantation (fmt). patients will receive follow-up for at least 12 weeks. blood test, endoscopy and questionnaire will be used to access participants at study start and at study completion. fecal microbiota compositions, blood and urinary metabolic profiles of patients will be analyzed to assess associated microbial changes.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years old; 2. radiation enteritis diagnosed by colonoscopy after finishing radiotherapy. exclusion criteria: 1. patients who were pregnant or nursing; 2. patients who were unable or unwilling to undergo a gastroscopy; 3. patients who had gastrointestinal infection; 4. patients with cardiopulmonary failure.

Keywords: gut microbiota radiation enteritis fecal microbiota transplantation
relationship analysis between periodontal disease and atherosclerosis in japanese medical cooperation services

Conditions: Periodontal Disease; Atherosclerosis

Summary: objective: we aimed at analyzing the relationship between periodontal disease and atherosclerosis in medical treatment and periodontal treatment under medical and dental care across borders in a local cooperation system of japanese medical services. materials and methods: * a prospective multi-center case cohort study was conducted on 37 ambulatory medical patients (with lifestyle-related diseases under consultation in either of the medical clinics registered as collaborative investigation facilities) and 79 periodontal patients (who were seen by the dental clinics registered as collaborative investigation facilities). * medical treatment and clinical periodontal treatment were provided on the subjects under medical and dental care across borders by each internal medicine and dental clinics. * systemic examination of lifestyle-related disease and periodontal examination were performed before and after periodontal treatment, and the relationships between periodontal and atherosclerosis-related clinical markers were analyzed before and after periodontal treatment.


Eligibility criteria:
inclusion criteria: * periodontal disease: inflamed gingiva with positive for bleeding on probing or teeth with probing pocket depth more than 4 mm lifestyle-related disease: plaques are included when maximum imt is measured. furthermore, hypertension was defined as systolic blood pressure of more than 140 mm hg or diastolic pressure of more than 90 mm hg, or both, or patients already being treated by anti-hypertensive agents. hypercholesterolemia was defined by serum concentration of ldl-c of more than 140 mg/dl, or patients already being treated by lipid-lowering agents. diabetes mellitus was defined by hba1c of more than 6.9 % (ngsp value) or fasting blood sugar of more than 126 mg/dl or both, or patients already being treated by agents for diabetes. exclusion criteria: * at initial consultation and examination (baseline), patients with less than 6 months after the onset of acute myocardial infarction (ami), and with a past history or complication of serious heart disease were excluded. similarly, those with less than 6 months after cardiovascular revascularization surgery, less than 6 months after the onset of cerebrovascular disorder, or serious liver disease or renal disease were also excluded.
the effect of presbyphagia on urinary incontinence and quality of life in healthy elderly people in nursing homes

Conditions: Presbyphagia; Incontinence, Urinary; Quality of Life

Summary: urinary incontinence in the elderly and health-related quality of life due to urinary incontinence is a common problem in nursing homes. another problem that occurs in elderly individuals is swallowing disorder. swallowing disorders that occur with aging are called presbyphagia. additional health problems such as impaired fluid intake balance, fetal incontinence and sarcopenia may occur after presbyphagia. however, the effect of presbyphagia on urinary incontinence is not known. in this study, we aimed to determine the effect of presbyphagia on urinary incontinence and quality of life in healthy elderly individuals living in a nursing home.


Eligibility criteria:
inclusion criteria: * individuals who have been living in the nursing home for at least 1 year and volunteer to participate in the study * a mini metal test score of 24 and above exclusion criteria: * those who cannot provide information on urinary function and quality of life, * those with a history of disease and surgery with mechanisms directly related to swallowing and urinary incontinence, * those with a mini mental test score of 23 or less were excluded

Keywords: presbyphagia urinary incontinence quality of life
self-assembled skin substitute for the treatment of epidermolysis bullosa

Conditions: Epidermolysis Bullosa Dystrophica

Summary: single patient study. patient diagnosed with dystrophic epidermolysis bullosa presenting chronic open wounds that are not responding to dressings, topical preparations (antimicrobials, antibiotics) and systemic agents (anti-inflammatory antibacterials). the self-assembled skin substitutes will be used to cover wounds.


Eligibility criteria:
this clinical trial was custom designed for one patient

Keywords: dystrophic epidermolysis bullosa recessive dystrophic epidermolysis bullosa tissue engineering skin substitute
phase 2 study to evaluate safety and efficacy of investigational drug - pf04937319 in patients with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: b1621007 is designed to study the safety and efficacy of pf-04937319 in patients with type 2 diabetes


Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes, on metformin, age between 18-55 yrs, male or female exclusion criteria: * patients with type 1 diabetes, medically unstable, unacceptable clinical laboratory test results at screening

Keywords: phase 2 type 2 diabetes mellitus pf-04937319
doctor's health - health behavior of physicians in germany

Conditions: Chronic Diseases; Chronic Illnesses

Summary: this is an observational study to assess the health behavior of physicians from medical practices in germany. physicians will be asked by a questionnaire (self-report) on health behavior, self-diagnostics and self-medication in case of sickness. we will send the questionnaire to 1000 general practitioners and to 300 medical specialists in germany. we expect a response rate of 25-30 %. after electronically data-entry we will run a descriptive analysis for primary outcome. results may provide a better understanding of the physicians health behavior.


Eligibility criteria:
inclusion criteria: * physicians in german ambulatory setting exclusion criteria: * any
single-center prospective longitudinal study of taste in patients with cognitive disorders at different stages of severity (isolated cognitive complaint, minor or major neurocognitive alzheimer-type disorders) by analysis of gustatory evoked potentials

Conditions: Cognitive Disorders

Summary: the aim of the mapeg 2 study is to explore gustatory function and to follow its evolution in the 4 following groups of participants: * healthy subjects * participants with isolated cognitive complaint * participants with minor neurocognitive disorder * participants with mild and moderate alzheimer-type major neurocognitive disorders for this purpose, we want to compare the results of the following tests: * subjective taste tests (tasting solutions, answering food preference questionnaires), * gustatory evoked potential (gep) parameters, recorded by electrodes placed on the scalp, * and nutritional parameters (hormones of food intake by blood test, measurement of the global body composition). identifying and following the evolution of early taste disorders in case of cognitive disorders could improve the diagnosis of alzheimer\&#39;s disease in two ways: * to allow an early diagnosis of alzheimer\&#39;s disease, and thus improve its management, * to define groups of subjects at risk of developing alzheimer\&#39;s disease in later years.


Eligibility criteria:
inclusion criteria: * person who has given oral consent. * for patients with mild to moderate alzheimer\&#39;s disease, the primary caregiver and the patient will be asked to provide oral consent * person of legal age * body mass index (bmi) \&lt; 30 kg/m². * for the healthy group: absence of cognitive complaints and normal neurological assessment * patients meeting the criteria for isolated cognitive complaint: presence of cognitive complaint but normal neuropsychological evaluation * patients meeting diagnostic criteria for minor cognitive impairment: imaging (brain mri) and neuropsychological assessment with a clinical dementia rating (cdr) score of 0.5 * patients meeting diagnostic criteria for mild to moderate alzheimer\&#39;s disease: imaging (brain mri), neuropsychobiological criteria (consultation with neuropsychological assessment, csf biomarkers), mmse score ≥ 20 and cdr score of 1 or 1.5 * fasting for at least 2 hours before gep measurement exclusion criteria: * mmse score\&lt;15 * known covid-19 infection within 6 months prior to inclusion * person not affiliated to national health insurance system * person under a legal protection measure (curatorship, guardianship) * person subject to a measure of legal protection * pregnant, parturient or breastfeeding women * subjects with a pacemaker (contraindication to bioelectrical impedance measurement) * adult unable to express consent or to perform cognitive tests. * active smoker (\&gt; 4 cigarettes per day on a regular basis) * diabetic subject (type 1 or type 2) * subject with acute or chronic ent disease * treatment interfering with gustation * brain mri showing another cause of neurocognitive disorder (except for vascular lesions fazekas 1 accepted)
analysis of human movement with assistive devices

Conditions: Limb Loss; Limb Weakness; Limb Paralysis; Movement Disorders

Summary: the purpose of this research is to evaluate how people move about in different settings with different assistive devices or components, and to understand how people interact with different assistive technologies. individuals that have limb weakness, limb paralysis, limb loss, and movement disorders are often provided assistive devices such as prostheses and orthoses to assist with mobility or use assistive technologies for purposes such as to regain muscle strength or retrain movements. it is important to understand the impact of these different assistive technologies on human movement for technology improvement and in preparation for commercialization. because this research focuses on evaluating how different people move about in different settings with different assistive devices/components, there are different activities that may take place. these activities have been classified as (1) movement analysis in the laboratory, (2) movement analysis outside the laboratory, (3) usability testing, and (4) focus groups. each participant may or may not complete the same activities as the other participants. each participant may or may not complete all of the activities. participants may complete the activities more than once.


Eligibility criteria:
inclusion criteria for nondisabled participants: * age 18 - 90 years * has bilateral normal range of motion * able to perform a variety of movement activities * able to communicate and write individual perceptions in english * able to provide written informed consent * participants that will use a treadmill during data collection must also be able to walk independently and safely on a treadmill exclusion criteria for nondisabled participants: * health issues (e.g., confounding injury, musculoskeletal, or cognitive) or other issues (e.g., transportation or schedule issues) that limit effective participation and/or may not represent a nondisabled condition * pregnancy * not able to read and understand english inclusion criteria for participants with a disability: * age 18 - 90 years * has a condition or diagnosis that results in limb weakness, limb paralysis, limb loss, or movement disorders * medically stable * has stable balance * able to perform a variety of movement activities * able to communicate and write individual perceptions in english * able to provide written informed consent * participants that will use a treadmill during data collection must also be able to walk independently and safely on a treadmill * able to safely complete the movements being tested and/or safely use the assistive devices being tested exclusion criteria for participants with a disability: * health issues (e.g., confounding injury, musculoskeletal, or cognitive) or other issues (e.g., transportation or schedule issues) that limit effective participation and/or may result in mixed effects of multiple sources of disability * pregnancy * not able to read and understand english
group videoconferencing intervention to improve maternal sensitivity

Conditions: Parent-Child Relations; Parenting

Summary: background: early childhood development is highly dependent on the sensitive care provided by their caregivers . interventions focused on supporting parents to improve their sensitivity have been shown to be effective . the covid-19 pandemic has had a great impact on mental health , with pregnant women and mothers of children under one year of age being an especially vulnerable group . on the other hand, access to mental health interventions in person is restricted by confinement measures , especially group interventions, so it is relevant to have remote interventions that support this group of mothers. objectives: to evaluate the feasibility and acceptability of a group videoconferencing intervention to improve maternal sensitivity aimed at mother / infant dyads attended in primary health care in chile methodology: a randomized pilot feasibility study will be carried out with a mixed design with quantitative and qualitative evaluations. a face-to-face group intervention with proven effectiveness will be adapted to videoconferencing format , then 50 dyads will be randomized in a 3: 2 ratio to receive the videoconferencing intervention ( n=30) or the delivery of educational brochures (n=20) . the feasibility and acceptability will be evaluated assessing the participation, adherence and satisfaction in a quantitative way, in addition the qualitative evaluation will be carried out through interviews and focus groups. changes in clinical outcomes will also be evaluated: maternal sensitivity, depressive symptoms, postnatal maternal attachment and infant socio-emotional development. this pilot study will allow the identification of the key parameters for the implementation and evaluation of the intervention, which will allow the design of an effectiveness study in the future.


Eligibility criteria:
inclusion criteria: * mother of a baby between 4 months and a year * attended at one of the participating primary care health centers * older than 18 years-old * handling spanish fluently * have an electronic device that allows videoconferencing (computer, tablet or smart cell phone) exclusion criteria: * mother with severe intellectual deficit or psychotic symptoms * participate in another early intervention at the health care center

Keywords: maternal sensitivity videoconferencing group intervention primary care telehealth