Kornimate/medical-research-clean huggingface dataset:
exploring the relationship between l-dopa responsiveness and small intestinal microbiome in parkinson's disease

Conditions: Parkinson Disease

Summary: the investigators hypothesize that small intestinal (si) microbiome biomarkers predict the responsiveness to oral levodopa/carbidopa in people with parkinson's disease (pwpd). the investigators will analyze the bacterial species and function of bacterial pathways influencing the responsiveness of pwpd to oral l-dopa. the investigators will pursue this goal using a reliable capsule system (simba capsule, nimble science, calgary, ab) that suitably captures si luminal fluid for multi-omics analysis.


Eligibility criteria:
inclusion criteria: 1. males and females aged 50-85 years old at time of on-site visit. (ages 81-85 will be assessed on a per case basis by the principal investigator) 2. signed informed consent. 3. willing \& able to comply with study procedures (including simba capsule ingestion) and have study assessments performed. 4. able to swallow a size-00 capsule (25mm length) in off state. 5. diagnosis of idiopathic pd (clinically probable pd), including documented levodopa responsiveness. 6. treatment with an immediate release levodopa formulation during the day at a stable dose for at least 2 months prior to enrollment. exclusion criteria: 1. any risk of capsule non-excretion related to intercurrent gastrointestinal conditions. 2. use of any medications in the week prior to the on-site study visit, unless part of regular treatment, that could substantially alter gastrointestinal motor function. 3. history of oropharyngeal dysphagia, or other swallowing disorder with a risk of capsule aspiration, e.g., sdq score \> 4. 4. any concomitant or previous treatment (\<2 months from on-site study visit) with significant anti-inflammatory or immune suppressant medication, e.g., dmards, biologicals or systemic corticosteroids, except non-chronic prn use of an nsaid and/or 5-asa (mesalazine) treatment. 5. active cancer within 5 years. 6. clinically significant immune deficiency (according to investigator's judgement). 7. antibiotic use (except for local use), ≤12 weeks prior to on-site study visit, or fecal microbiota transplantation anytime in medical history. 8. use of prebiotics, or probiotics ≤2 weeks prior to the on-site study visit. 9. dementia in medical history. 10. insulin-dependent diabetes mellitus. 11. current psychosis episode by clinical judgement based on anamnesis. 12. pregnancy. 13. alcohol or drug abuse. 14. deep brain stimulation or duodopa/lecigon treatment.

Keywords: simba small intestine l-dopa
study of ha20 (humanized anti-cd20) in patients with cd20+ non-hodgkin's lymphoma

Conditions: Non-Hodgkin's Lymphoma

Summary: this is a phase i trial to look at safety and how a patient's body will tolerate the treatment at different dosages.


Eligibility criteria:
inclusion criteria: * cd20+ b-cell non-hodgkin's lymphoma (nhl) with measurable disease

Keywords: treatment nhl cd20+ b-cell nhl lymphoma
effects of procedure started in the morning and afternoon on early postoperative sleep function and postoperative recovery in patients under general anesthesia

Conditions: Postoperative Complications

Summary: the present study was conducted in laparoscopic hysteromyoma patients, aiming to compare the effects of morning surgery with afternoon surgery on early postoperative sleep function and postoperative recovery under general anesthesia.

the circadian rhythm is an intrinsic timing mechanism generated by endogenous systems to adapt to the external environment, which is closely related to the human sleep-wake cycle. patients after major surgery are prone to changes in sleep structure and sleep quality, called postoperative sleep disturbances (posd), which are characterized by the total sleep time reduced, rapid eye movement sleep absent, slow wave sleep shortened, and shallow sleep phase increased, times of wakefulness increased, and highly fragmented sleep. some studies have shown that posd can aggravate postoperative pain and fatigue, increase postoperative delirium, cardiovascular adverse events, and even cause accidental death of patients. the investigators don't know whether the early postoperative sleep function and postoperative recovery quality of patients undergoing general anesthesia are affected by surgery in the morning or in the afternoon. the present study was conducted in laparoscopic hysteromyoma patients, aiming to compare the effects of morning surgery with afternoon surgery on early postoperative sleep function and postoperative recovery under general anesthesia.

Eligibility criteria:
inclusion criteria: 1. aged 18-60 years old. 2. asa status i or ii. 3. bmi 18.5-28 kg/m\^2. 4. performed with laparoscopic myomectomy. exclusion criteria: 1. combining with ovarian disease or ovarian surgery. 2. preoperative athens insomnia scale (ais) score ≥ 4 points 3. chronic use of sedative, hypnotic, psychotropic drugs. 4. recent night shift, cross-time zone, irregular life routine. 5. suffering from mental illness or hearing, visual impairment, and existing sleep apnea syndrome. 6. patients withdraw, or were unable to complete the trial after surgery. 7. lossed bleeding volume more than 500 ml during surgery. 8. performed procedure time exceeded 2 h.

Keywords: postoperative sleep disturbances postoperative recovery general anesthesia early postoperative sleep procedure started in the morning and afternoon
hiit for inflammatory rheumatic disease: man vs machine

Conditions: Inflammatory Rheumatism

Summary: the purpose of this study is to compare two modes of delivering high-intensity interval training (hiit) in a population with inflammatory rheumatic disease over 10 weeks. one group will recieved hiit supervised by a healthcare professional, the other group will perform self-monitored hitt with guidance by a smarthpone application.

people with inflammatory rheumatic diseases (irs) such as rheumatoid arthritis (ra), spondyloarthritis (spa) and systemic lupus erythematosus (sle) have been shown to have reduced cardiovascular fitness and quality of life than the general population. cardiovascular health is the single most important factor of total mortality. it has been shown previously that individuals with irs tolerate both endurance training, resulting in improvement in function and cardiovascular health while also having a positive effect on disease activity measured through inflammation, pain, joint health and fatigue. in recent years, studies have also been conducted that demonstrate both the safety and effect of aerobic 4x4min high-intensity interval training (hiit) for patients with irs. this study will involve an intervention period consisting of 20 hiit sessions. participants are randomized into one of two training groups. one group will perform hiit under the supervision of a healthcare professional. the other group will perform the same hiit training with identical instructions, however they will be self-monitored with the aid and guidance of a mobilephone application. the purpose of the intervention is to increase maximum oxygen uptake and improve quality of life. the intervention period will consist of 2 weekly sessions lasting approximately 35 minutes performed on non-consecutive days. the endurance training will consist of 4 intervals of 4 minutes duration, separated by a 3-4 minute active break and follows the principle of intensive aerobic interval training. before and after the training period, identical testing (approximately 30-40 min) will be performed by both intervention groups. the testing will include measurements of work economy and maximal oxygen uptake in an endurance test. additionally, quality of life questionnaires will be obtained.

Eligibility criteria:
inclusion criteria: - inflammatory rheumatic disease exclusion criteria: * inability to complete the testing procedures * pregancy * not able to perform exercise intervention * planed surgeries or other plans during initial exercise intervention period than directly will effect the testing or training. * access to a smartphone * less than 80% compliance of planned training sessions

Keywords: vo2max cardiovascular health quality of life endurance exercise
comparison between open and laparoscopic splenic aneurysms repair

Conditions: Splenic Artery Aneurysm

Summary: the purpose of this study is compare two different surgical treatments of splenic artery aneurysms: open and laparoscopic approach.

laparoscopy has not spread into vascular surgery as it has in other surgical branches and still remains in the hands of a minority of surgeons. splenic artery aneurysm (saa) is an exception to the rule: an easy-to-reach position and relatively safe control favour the progressive diffusion of laparoscopic techniques. an increasing number of cases is managed by minimally invasive surgery originating a number of case reports and small series published in recent literature. these papers are unanimous in signalling the feasibility, safety and effectiveness of laparoscopic technique as well as its appreciation by patients -often young females- who harbour the disease. however, perplexities still remain concerning the real potential of laparoscopy in this specific field, in particular considering the spectrum of technical solutions to be performed, the splenectomy rate and the feasibility and results of reconstructive surgery. the low incidence of the disease justifies the low number of published laparoscopic series enrolling an adequate number of patients and, in particular, the absence of papers comparing open and laparoscopic techniques. this study reports the first prospective randomized comparison of the different surgical techniques.

Eligibility criteria:
inclusion criteria: * splenic artery aneurysm with diameter greater than 2 cm * splenic artery aneurysm with diameter smaller than 2 cm if risk factors for rupture are associated (child bearing age, pregnancy, blister or saccular shape, increasing diameter) exclusion criteria: * complex aneurysm involving the celiac trunk * american society of anesthesiologists (asa) score \> 3

Keywords: splenic artery aneurysm laparoscopic vascular reconstruction splenectomy
ceritinib rare indications study in alk+ tumors

Conditions: Tumors With Aberrations in ALK; Anaplastic Large Cell Lymphoma; Inflammatory Myofibroblastic Tumor; Glioblastoma

Summary: this is proof-of-concept (poc) study to assess the preliminary antitumor activity and safety and tolerablity using ceritinib (ldk378) in the treatment of life threatening tumors that are characterized by alk genetic alteration (and/or overexpression in some diseases).


Eligibility criteria:
inclusion criteria: * patient has a histologically or cytologically confirmed diagnosis of alk positive (alk+) tumor other than non-small cell lung cancer (nsclc). * patient must provide an archival or fresh tumor tissue before the first dose of the study drug for alk testing at a novartis designated central laboratory. * patient has who performance status (ps) ≤ 2 * patient must have received at least one line of prior systemic treatment for recurrent, locally advanced and/or metastatic disease, and may have discontinued for: * disease progression as defined by recist 1.1 for solid tumors; by rano for gbm and by cheson assessment criteria for lymphoma, or * intolerance described as any discontinuation due to an ae of any grade despite appropriate supportive treatment * patient has at least one measurable lesion as defined by appropriate guidelines. a lesion at a previously irradiated site may only be counted as a target lesion if there is clear sign of progression since the irradiation. * patient has received no chemotherapy, immunotherapy or stem cell therapy at least 4 weeks before starting ceritinib * radiotherapy and prior alk inhibitors must be stopped at least 1 week prior to starting ceritinib * recovered from all toxicities related to prior anticancer therapies to grade ≤ 1 (common terminology criteria for adverse events \[ctcae\] v4.03). exclusion criteria: * patient has alk+lung cancer * patient with symptomatic cns metastases who are neurologically unstable or have required increasing doses of steroids within the 2 weeks prior to study entry to manage cns symptoms. * patient with acute or chronic gi disease that may significantly alter the absorption of ceritinib. * patient with a history of pancreatitis or history of increased amylase or lipase that was due to pancreatic disease. * patient has history of interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis. * patient has clinically significant, uncontrolled heart disease and/or recent cardiac event (within 6 months). * patient has evidence of active viral hepatitis, including hepatitis a, b or c (testing for viral hepatitis is not mandatory). * patient has known diagnosis of human immunodeficiency virus (hiv) infection (hiv testing is not mandatory).

Keywords: alk gbm hematological malignancy anaplastic lymphoma kinase glioblastoma anaplastic large cell lymphoma imt inflammatory myofibroblastic tumor
sensory integration therapy and cerebral palsy

Conditions: Cerebral Palsy

Summary: this intervention study was planned to investigate the effects of sensory integration therapy that added to the conventional therapy program on spasticity, balance, motor function and functional independency levels of children with spastic diplegic cerebral palsy

cerebral palsy is a disease that can cause motor skill and posture disorders due to a non-progressive lesion in the brain that has not yet completed its development. cerebral palsy is among the most common causes of disability in childhood. there are many conditions that can cause cerebral palsy. risk groups that cause brain damage can be considered as prenatal, perinatal and postnatal risk factors.the lesion that occurs in the central nervous system in patients with cerebral palsy causes some problems in the musculoskeletal system, nervous system and sensory systems. in addition to these problems, depending on the level of the lesion, posture, movement disorders and balance problems occur in individuals with cerebral palsy. sensory integration therapy is a neurological process of perceiving, interpreting and organizing our senses for an effective integration of the individual with the environment. when the literature is examined, the number of studies investigating the effect of sensory integration program in children with spastic diplegic type cerebral palsy is insufficient. the aim of this study is to investigate the effect of sensory integration therapy on spasticity, balance and motor function in children with spastic diplegic type cerebral palsy and to provide the data obtained at the end of the study to the literature both theoretically and practically. the hypothesis of the study is: * sensory integration program reduces spasticity in children with spastic diplegic type cerebral palsy. * sensory integration program increases balance in children with spastic diplegic type cerebral palsy. * sensory integration program increases motor function in children with spastic diplegic type cerebral palsy.

Eligibility criteria:
inclusion criteria: * between the ages of 4-17 * diagnosed with spastic diplegic type cerebral palsy * having gross motor function classification system levels i and ii exclusion criteria: * children who underwent phenol and botulinum toxin-a injections in the last 6 months before the study * had a previous surgical operation, and had a cardiopulmonary disease that could prevent exercise * children with communication, hearing and vision problems

Keywords: sensory integration physical therapy and rehabilitation
a phase ii trial on treatment of steroid-refractory bronchiolitis obliterans with interferon gamma 1b after allogeneic sct

Conditions: Steroid-refractory Bronchiolitis Obliterans

Summary: improvement of quality of life in patients with bo and establishment of a new third line therapy

primary objectives: objective improvement of lung function, i.e.: * improvement of so2, po2 or pco2 in oxygen dependent or improvement of fio2 in respiration dependent patients ≥ 20 % or * reduction of oxygen need in oxygen dependent patients ≥ 1l o2/min with constant parameters at blood gas analysis (bga) or * improvement of obstructive parameters ≥ 20 % or * improvement of lung function score (lfs) at least about one grade improvement of lung function should be detectable at least by two consecutive examinations of lung function or bga within at least four weeks. secondary objectives * morphological improvement of bo/boop at ct scan * reduction of steroids about at least 20 %

Eligibility criteria:
inclusion criteria * allogeneic sct * age ≥ 18 years * bo, firmed by 2 out of 3 examinations: * lung function/ bga * ct scan in in- and expiration or * histological diagnosis * therapy refractory bo, i.e. no improvement during at least three therapies, among: * azithromycin + inhaled steroids/ bronchodilators * systemic steroids 1 mg/kg bw * one of the following therapies: mmf, mtor inhibitors or ecp * effective contraception (before, during and for 8 weeks after the treatment) * blood count: no severe neutropenia, defined as anc \> 1000/ml, platelets \> 50/nl and haemoglobin \> 8 g/dl * liver parameters (bilirubin, gammagt, ap, asat, alat) lower than 3 x paramount normal range * kreatinin lower than 3 x paramount normal range * informed consent exclusion criteria: * age \< 18 years * pregnant or nursing woman * no appropriate contraception * participation in any other study within 4 weeks before or during the study * active acute gvhd of other organs than the lung \> grade ii or severe active chronic gvhd * no appropriate antibiotic/ antimycotic therapy in documented infection * severe bone marrow suppression (anc \< 1000/ml) or graft failure * liver parameters (bilirubin, gammagt, ap, asat and alat) higher than 3 x paramount normal range * kreatinin higher than 3 x paramount normal range * participation in another study within 4 weeks before or during the study

Keywords: steroid-refractory bronchiolitis obliterans allogeneic stem cell transplantation interferon gamma
extent of central lymph node dissection in papillary thyroid microcarcinoma

Conditions: Carcinoma

Summary: occult lymph node metastasis is common in micro papillary thyroid cancer. however, the role of lymph node dissection in the treatment of microptc remains controversial. the investigators want to investigate the usefulness routine central dissection and sentinel lymph node biopsy in prognosis of micro ptc. this is a prospective randomized control study. the investigators started this study from may of 2009 and this study will be continued until dec. 2011.

the investigators will assign all patients to three groups; no dissection group (group i), sentinel lymph node biopsy only group (group ii) and routine central neck dissection group (group iii). at first, to know the necessity of routine central neck node dissection for micro ptc,the investigators will compare the result of group i and group iii. additionally, the investigators can analyze the usefulness of sentinel lymph node biopsy for substitution of routine central neck node dissection for micro ptc.

Eligibility criteria:
inclusion criteria: * papillary carcinoma of thyroid (less than 4cm) * no evidence of lymph node metastasis in preoperative work-up result * the patients who accept this study exclusion criteria: * large thyroid cancer( \> 4cm) * morbid * anticoagulation agent usage * endoscopic or robotic thyroid operation * evidence of lymph node metastasis or extrathyroidal extension in preoperative us and ct scan

Keywords: neck dissection sentinel lymph node carcinoma papillary thyroid dissection
improving cardiac rehabilitation outcomes through mobile case management (icare)

Conditions: Acute Myocardial Infarction; Acute Coronary Syndrome; Stable Angina Pectoris; Percutaneous Coronary Intervention; Heart Failure

Summary: the purpose of this research is to find out if doing cardiac rehab at home, or a mix of cardiac rehab at home and in the clinic, is as effective as coming in to the clinic for cardiac rehab.

to address our specific aims we will use a single-center, prospective, three-arm, parallel group, randomized controlled trial design. at the time of identification of eligibility for participation, patients will be randomized to one of three arms (1:1:1 ratio): arm 1 consists of patients randomized to conventional cardiac rehab only, arm 2 consists of patients randomized to conventional cardiac rehab with the addition of the mhealth platform, and arm 3 consists of patients randomized to remote case management using the mhealth platform only. clinical metrics will include traditional cardiovascular risk factors with additional tracking of service utilization and adherence, and quality of life. measures will be made at baseline (pre-intervention) and \~3-months (coinciding with completion of conventional cr). additional follow-up will occur at 12 months post cr entry. randomization to study arms will be done with a multidimensional dynamic allocation algorithm, minimizing imbalances in age, sex, body mass index, and race across study arms.

Eligibility criteria:
inclusion criteria: * own or have reliable access to a smartphone or desktop computer with internet access * have an email address * patients who have a history of one of the following; acute myocardial infarction/acute coronary syndrome, stable angina pectoris, percutaneous coronary intervention, or heart failure. * patients who have undergone a surgical procedure which includes an indication for cardiac rehabilitation (coronary artery bypass surgery, heart valve repair/replacement, or heart transplant) exclusion criteria: * patients referred to cardiac rehab with ventricular assist devices.

Keywords: cardiac rehabilitation
repetitive transcranial magnetic stimulation(rtms) in the treatment of depression

Conditions: Major Depressive Disorder

Summary: the objective of this study is to investigate the antidepressant efficacy of rtms, and to assess cortical metabolism before and after rtms sessions in patients with major depression. we also aimed to investigate differences between the responders and nonresponders to rtms and what would predict clinical response to rtms.

the specific aims of this study is to: (1) evaluate the antidepressant efficacy of rtms on major depression; (2) evaluate the effects of rtms on cognitive function in depressive patients; (3) assess the effects of rtms on cerebral glucose metabolism in depressive patients as measured by 18fdg pet; (4) investigate the differences of the regional cerebral glucose uptake changes during rtms between responders and nonresponders to rtms.

Eligibility criteria:
inclusion criteria: * twenty patients fulfilling the diagnostic criteria of major depression according to dsm iv will be enrolled in the study. * antidepressant medication will be maintained throughout the study period. exclusion criteria: * exclusion criteria are current neurological or other psychiatric disorders, as well as a history of epileptic seizures, substantial brain damage or neurosurgical operation, according to established safety criteria. * to exclude the effect of drug changes on post-rtms cerebral glucose metabolism, the combinations and dosage of pre-rtms antidepressant drugs will remain unchanged until the post-rtms 18fdg pet is done.

Keywords: repetitive transcranial magnetic stimulation major depressive disorder