Kornimate/medical-research-clean huggingface dataset:
smartphone apps for pediatric resuscitation

Conditions: Status Epilepticus; Anaphylaxis

Summary: medication errors are common in children. characteristics of errors during critical situations in the emergency department are ill-defined and might be more frequent than previously thought. however, optimal strategies to eliminate the risk of prescribing errors remain unknown. many smartphone apps have been suggested over the last years with some of them designed to calculate medication dosage for children. the impact of these apps to decrease dosage error has never been evaluated in resuscitation setting. the aim of the study is to evaluate whether the use of a smartphone application designed to calculate medication doses decreases prescribing errors among residents during pediatric simulated resuscitations. this will be a crossover-randomized trial using high fidelity simulation among 40 residents rotating in the pediatric emergency department.


Eligibility criteria:
inclusion criteria: * residents (pgy1 to pgy4) * completing a rotation in pediatric emergency exclusion criteria: * residents who previously participated in this study

Keywords: children resuscitation smartphone
effects of hydrotherapy on physical function and quality of life of women with fibromyalgia

Conditions: Fibromyalgia

Summary: fibromyalgia syndrome (fs) is one condition that most affects functional performance, especially in women, due to alterations in the entire musculoskeletal system. given that, physical therapy (pt) studies the human movement and its dysfunctions, and that fs, because of its complex chronic characteristic, impairs the affected individual's activities causing movement disorders, a pt professional must be part of the multidisciplinary team involved in the fs treatment. nonetheless, as explained in the present proposal, several aspects still need clarification related to the pt role in this syndrome. particularly, studies that analyze the biomechanical, sensorial and cardiorespiratory adaptations in individuals who undergo pt intervention still lack; those studies would contribute with scientific evidence to the clinical practice. according to recent systematic reviews, one of the most used therapies with positive effects on fs subjects is the hydrotherapy, which combines exercises and the water relaxing effects. other alternative treatments have also been searched, in an attempt to decrease the painful picture presented, as the fs etiology and pathophysiology are not well known. the aim of this study is to evaluate the efficacy of different physical therapy resources in the fs, in two subprojects. the first will verify if hydrotherapy is effective in modifying movement variables (scapular kinematics and electromyography) and autonomic modulation. other variables, such as pain level and quality of life in women with fs, will also be analyzed. the second study will evaluate the efficacy of the shiatsu massage on pain, sleep quality, balance and quality of life of subjects with fs.

subjects were invited to take part in several assessments before starting the actual hydrotherapy treatment. these assessments were: 1. three-dimensional scapular evaluation 2. questionnaires (fiq, sf-36, beck depression inventory, beck anxiety inventory, pittsburgh quality of sleep index) 3. pain (pressure pain threshold and trigger points) subjects were evaluated 3 times one month before starting treatment, one time in the middle of treatment and after treatment completion. treatment lasted 16 weeks and consisted of 2 weekly 45' hydrotherapy sessions.

Eligibility criteria:
inclusion criteria: * to have a clinical fibromyalgia diagnosis according to the 1990 acr criteria * to be aged from 30 to 60 years old. exclusion criteria: * body mass index \>28kg/m² * cognitive deficits that prevented patients to understand the evaluation procedures * uncontrolled systemic illnesses (e.g. diabetes mellitus and systemic arterial hypertension) * neurological and musculoskeletal conditions that could have directly interfered in the evaluations, as paresis, important sensitive alterations, advanced joint diseases (e.g. arthroplasties or osteoarthritis) * infections * urinary incontinence * pregnancy

Keywords: kinematics fibromyalgia physical therapy 3d kinematics heart rate frequency hydrotherapy
ultrasound-guided rectus sheath block in children

Conditions: Postoperative Pain

Summary: inguinal hernia repair is one of the common day-case surgery in children. the aim of this study is to compare the effects of ultrasound guided rectus sheath block and intravenous tramadol on peroperative anesthetic requirement and postoperative analgesia.

after approval the faculty ethical committee and informed consent from the parents (legal guardian) forty children aged 2-7 years scheduled for inguinal hernia repair were included in this prospective, randomized study. the patients were divided into two groups. after induction of general anesthesia, ultrasound guided rectus sheath block was applied to group r with 0.2 ml/kg levobupivacain 0.25%. tramadol 1 mg/kg intravenously was given to group t before closure of the fascia. intraoperative and postoperative hemodynamic parametres, postoperative pain by means of the flacc were evaluated. primary end point was pain score using flacc scale.

Eligibility criteria:
inclusion criteria: * the children aged 2-7 years scheduled for inguinal hernia repair exclusion criteria: * american society of anesthesiologists (asa) classification iii or greater, history of long term analgesic use, use of any analgesic within 24 hours before surgery, bleeding disorder, infection of application area, ultrasound imaging was inadequate and inability of the flacc pain scoring system, substance sensitivity to local anesthetics.

Keywords: ultrasound, rectus sheath block, children, inguinal hernia
tumour and healthy tissues dose-response and radiosensitivity assay

Conditions: Sarcoma; Rectal Carcinoma; Esophagus Cancer

Summary: theodora is a prospective pilot clinical trial aiming at first to evaluate and validate the predictive value of the a \& ms bioassays on tumor control by radiotherapy.

for that purpose, this project is composed of 3 stages: * a calibration stage that will allow to evaluate the correlation between the clinical tumor response parameters (i.e. tv/ap features) and the radiobiological parameters issued from the a/ms bioassays in order to develop a mathematic model defining the utcr parameter * a validation stage in order to assess the validity of a/ms bioassays towards clinical tumour response parameters (i.e. both tv/ap features and utcr). * a precision stage will be performed either to improve the precision of the predictive performance of the a and ms bioassays or to establish a new mathematical model describing the correlation between clinical and radiobiological parameters. the objective of this precision stage will depend of the results of the calibration stage (see below). this prospective clinical study will be conducted in a population of patients with different tumor types in order to explore a large range of tumor radiosensitivity including sarcomas, rectal carcinoma and esophagus tumor.

Eligibility criteria:
inclusion criteria: i1. patients (male or female) ≥ 18 years of age. i2. adult patients with a suspected, non-treated, non-metastatic retroperitoneal or limb soft tissue sarcoma, esophagus cancer or rectum cancer to be treated by pre-operative radiotherapy or radio-chemotherapy i3. at least one measurable lesion as per recist 1.1 i4. documented negative serology tests (hvb, hiv, hvc) i5. ps ecog 0 to 1 i6. patient able and willing to provide informed consent. i7. ability to understand and willingness for follow-up visits. i8. covered by a medical insurance. exclusion criteria: e1. contra-indication to radiotherapy e2. contra-indication to skin biopsy

Keywords: radiation therapy radiosensitivity in vitro diagnostic medical devices adverse event post radiotherapy
cutaneous microcirculation after remote ischemic preconditioning

Conditions: Burn Injury; Acute Wound; Chronic Wound

Summary: in plastic and reconstructive surgery, treatment strategies of second-degree burns, superficial wounds and chronic wounds aim at reducing infection and improving microcirculation. although previous studies indicate that remote ischemic preconditioning (ripc) can accelerate wound healing, only a few studies focused on the elucidation of its mechanisms of action. therefore, the aim of this study is to evaluate the microcirculatory effects of remote ischemic preconditioning on second-degree burns, superficial and chronic wounds in a human in-vivo setting for the first time.


Eligibility criteria:
inclusion criteria: group a (n=20): consent-capable male and female patients ≥18 years of age who have sustained a second-degree burn on ≥1% and ≤30% of the surface of the body. group b (n=20): consent-capable male and female patients ≥18 years of age who require a skin excision for the purpose of a skin graft. the minimal size of the skin-graft donor site must not be less than 1% of tbsa. group c (n=20): consent-capable male and female patients ≥18 years of age suffering from a wound that has not yet healed ≥3 weeks. the minimal size of the wound site must not be less than 1% of tbsa. group d (n=20): consent-capable healthy male and female probands ≥18 years of age serving as sham group. none of the the criteria of groups a-c must be evident. no soft tissue injury must be evident. exclusion criteria: general exclusion criteria * below 18 years of age * wounds requiring artificial respiration, since consent for the study participation is unobtainable exclusion criteria groups a, b, d: * peripheral arterial occlusive disease * vasculitis * diabetes mellitus * chronic kidney or liver disease * cardiac dysfunction * arterial hypo- or hypertension anamnestic exclusion criteria * ongoing immunosuppressive or chemotherapy treatment * drug abuse * systemic skin diseases * systemic and local cortisone therapy
a trial of computer-based attention-training systems in children with attention deficit hyperactivity disorder (adhd)

Conditions: Attention Deficit Hyperactivity Disorder

Summary: this study examines the efficacy of two computer-based training systems to teach children with adhd to attend more effectively.


Eligibility criteria:
inclusion criteria: * child in 6th, 7th or 8th grade * a diagnosis of adhd (any subtype) per report of the child's physician * academic achievement at grade level * ability to read in english sufficiently to complete assessments and intervention protocols exclusion criteria: * coexisting diagnosis of conduct disorder, pervasive developmental disorder, or other serious mental illness (e.g., bipolar disorder, psychosis)

Keywords: eeg-biofeedback neurofeedback computer attention training systems adhd add child children
using of acellular dermal matrix in cleft palatal fistula and compare with use of conchal cartolage

Conditions: Cleft Palate

Summary: the fact that still exist is which method for repairing of secondary cleft palatal fistula is the best. this study will have shown whether using of acellular dermal matrix decreased the fistula formation versus using conchal cartilage during secondary fistula. among studies that published, they have not consensus for using acellular dermal matrix. most of the questions are about cost effectiveness, time that surgery and rehabilitation need and patient risk ( risk of transmission disease from other human tissue )

observational study composed of a prospective cohort group receiving adm compared to a retrospective historical cohort group with conchal cartilage. primary objectives: the primary objective of this study is to determine whether adm would lower the incidence of palatal fistula in patients undergoing secondary cleft palate fistula repair. secondary objectives: 1. hypo nasality speech after surgery 2. improvement speech score

Eligibility criteria:
inclusion criteria: * patients diagnosed as having cleft palate fistula, with adm will be included in this study. exclusion criteria: * selection will be based on the patient's willingness to allow to participate in the study. * patients with diagnosed craniofacial syndromes will be excluded from the study. * children with known wound healing defects, will be excluded from the study.

Keywords: cleft palate
phase i study of orally administered aminolevulinic acid for resection of malignant astrocytomas

Conditions: Astrocytoma; Glioma

Summary: this research is being done to study the safety and utility of 5-aminolevulinic acid (5-ala) (also known as gliolan) for identifying brain tumor tissue during surgery. the goal of this study is to determine if 5-ala can differentiate between tumor and normal brain tissue. sometimes, during brain surgery, the removal of tumor tissue can be difficult because the tumor can look like normal brain tissue. studies in other countries have shown that in some brain tumors, 5-ala can make the tumors appear brighter under ultraviolet light. this may make it easier for doctors to remove as much tumor as safely as possible from your brain. this study also hopes to see if 5-ala can find different cell populations within the tumor that is removed and allow the researchers to better understand brain tumors. the purpose of this study is to: * find out how well 5-ala can separate normal brain tissue from tumor tissues and to see how well 5-ala can find different cell populations within brain tumors * identify the amount of 5-ala that should be taken before surgery to make the tumors glow under ultraviolet light * make sure the 5-ala identifies tumor and not normal brain * make sure 5-ala does not cause any side effects


Eligibility criteria:
inclusion criteria: * patients must have clinically documented primary brain tumor for which resection is clinically indicated. radiographic findings should be consistent with high grade glioma. intraoperative frozen section should either be: anaplastic astrocytoma (who grade iii astrocytoma) or glioblastoma (who grade iv astrocytoma). * patients must be aged greater than 18 years old * karnofsky performance score \> 70 (appendix) * patients must have normal organ and marrow function as defined below: * leukocytes \> 3,000 /ul * absolute neutrophil count \> 1,500/ul * platelets \> 100,000/ul * total bilirubin within normal institutional limits * ast/alt within normal institutional limits * creatinine within normal institutional limits exclusion criteria: * prior craniotomy for resection, deep seated tumors in thalamus and brain stem. * history of allergic reactions to compounds of similar chemical composition to ala. * personal or family history of porphyrias * personal history of hepatitis or other liver diseases. * pregnant women are excluded from this study because ala is of unknown teratogenic effects. because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with ala, breastfeeding should be discontinued prior to treatment with ala. * inability to undergo magnetic resonance imaging (i.e. those patients with aicd/pacemakers).

Keywords: 5-ala aminolevulinic acid craniotomy brain tumor surgical resection neurosurgery
interleukin (il)-13 as a marker in pediatrics asthma

Conditions: Asthma

Summary: asthma is a very common childhood chronic illness and is generally more severe in african americans. the investigators attempted to determine whether a specific immune marker is associated with lung function and asthma severity.

this study examined the relationship between interleukin (il)-13 from phytohemagglutinin-activated polymorphonuclear blood cells and asthma severity, lung function (measured as fev1%), and total serum ige levels in african american children with clinically diagnosed asthma

Eligibility criteria:
inclusion criteria: * african-american race, born in the u.s. * age 8-15 years * clinical diagnosis of asthma * subject is able to understand and follow verbal instructions in english exclusion criteria: * asthma exacerbation in the 4 weeks preceding the research visit * oral/iv steroid use in the 4 weeks preceding the research visit * upper or lower respiratory tract infection in the 4 weeks preceding the research visit * antibiotic use in the 4 weeks preceding the research visit * use of a short-acting bronchodilator during the 6 hours prior to spirometry (lung function testing) * use of a long-acting bronchodilator during the 12 hours prior to spirometry (lung function testing)

Keywords: african american children with stable asthma asthma severity interleukin 13 from pha stimulated pbmc lung function (fev1%) total serum ige pediatrics
personal precise treatment on psoriasis and psoriatic arthritis

Conditions: Dermatologic Disease

Summary: part of psoriasis and psoriatic arthritis patients treated with biologics and met primary failure. therefore, we are going to create a cell based platform to evaluate the treatment effects of different biologics on psoriasis and psoriatic arthritis patients before prescribed by physicians

pbmcs isolated from psoriasis and psoriatic arthritis and incubated with group a streptococcus and different biologics for 24 hours. cytokines expression in the culture supernatants will be measured and the data can be reference for physician's prescription.

Eligibility criteria:
inclusion criteria: * 1. healthy control without underline disease such as psoriasis and psoriatic arthritis. 2. psoriasis been diagnosed for over six months and pasi \>10. 3.psoriatic arthritis been diagnosed for over six months and \>1 swallow and tender joints exclusion criteria: * nil

Keywords: pso, psa, sle, pbmc
99mtc labeled fap targeted molecular probe in early diagnosis of tumors

Conditions: Head and Neck Tumor; Lung Cancer; Pancreatic Cancer

Summary: at present, radiopharmaceuticals targeting fap have been developed for the diagnosis and treatment of various tumors. considering the problems of fast tumor tissue clearance and short retention time in small molecule fap inhibitors based on quinoline rings, this project optimized their ligands and developed a new fap targeted technetium labeled molecular imaging probe for spect/ct imaging research to evaluate its safety in clinical application and its effectiveness in tumor diagnosis.


Eligibility criteria:
inclusion criteria: * voluntary subjects, patients or their legal representatives sign informed consent; * volunteers are of any gender and aged between 18 and 75 years old, including the cut-off value; * other imaging methods found tumor occupying; * patients with pre-treatment tumors for whom surgery or biopsy may be performed to obtain final pathological results. * kidney glomerular filtration rate(gfr)\>50 ml/min, effective renal plasma flow(erpf)\>280 ml/min, platelet count (plt) \>75 000/μl, white blood cell (wbc) \>3000/μl, alanine aminotransferase alt, aspartate aminotransferase ast less than 3 times the normal value. exclusion criteria: * people who have a history of allergy to similar drugs , allergic constitution or are currently suffering from allergic diseases; * is conducting clinical research on other drugs, or has participated in clinical research on any drugs (excluding vitamins and minerals); * have other clinical problems that are difficult to control (such as hepatitis c virus infection or active hepatitis b, or other serious chronic infections and serious mental, neurological, cardiovascular, respiratory and other diseases); * obvious abnormal liver and kidney function, gfr less than 50 ml/min; * tumor load is greater than 50%, or there is obvious spinal cord compression; * the expected survival period is less than half a year; chemotherapy was performed within 6 months. * have severe acute concomitant diseases or serious refractory mental disorders; * pregnant and lactating women (where pregnancy is defined as a positive urine pregnancy study); * patients whose physical condition is not suitable for radiological examination; * other situations deemed inappropriate by the investigator to participate in the trial.
a couple-based relationship strengthening hiv intervention for young parents

Conditions: HIV

Summary: this study seeks to develop, implement, and assess an innovative 15-session couple-based intervention to be delivered in a group format to young parents that aims to strengthen relationships and reduce hiv risk. the ultimate goal of our intervention is to reduce hiv/std risk (concurrency, number of partners, unprotected sex), strengthen relationships, and improve parenting among young parenting heterosexual couples.

this study develops a couple-based hiv prevention intervention that is innovative and important because it integrates an intervention that improves sexual health, relationship functioning, and parenting skills. our intervention will be integrated with an existing community based parenting program. by targeting high risk heterosexual couples experiencing an important life transition that increases their stress, conflict, and sexual risk, the investigators can provide maximum benefit to the men, women, and children in our communities. using the guiding framework of attachment theory and the principles of emotion focused therapy, the investigators will directly address issues of emotion, intimacy,and relationship functioning to create an intervention that strengthens romantic relationships and reduces hiv risk behavior. the investigators will conduct a small pilot randomized controlled trial of 50 parenting couples randomized to either the relationship strengthening hiv prevention intervention or an active control. the intervention will last 15 weeks and each session will be approximately 1.5 hours long. the investigators will assess couples at baseline, 4-months, and 8-months.

Eligibility criteria:
inclusion criteria: * women's age between 14 and 25 * men's age 14 or older * have a child that is 0-1 year old * in a romantic relationship with the mother/father of the baby * not known to be hiv positive * english speaking exclusion criteria: * child older than 1 year * hiv positive

Keywords: hiv
prevalence of wild type attr

Conditions: Wild-type Transthyretin Amyloidosis

Summary: prospective, observational, single-centre, non-interventional study aiming at reporting the prevalence of attrwt in patients with lumbar spinal stenosis (lss).

the study will include patients that receive surgical management and treatment for lss, and will consist in the prospective, longitudinal collection of peripheral blood, urine samples, tissue biopsies and clinical data. the results of the project could provide a future benefit for patients with the same condition by: i) identifying accessible and sensitive biomarkers for the identification of patients at risk for having an underlying attrwt; ii) optimizing the therapeutic strategies in an era of innovative but cost-intensive treatments; iii) provide the proof of principle for a regular follow-up of patients who eventually will become symptomatic for overt organ attrwt involvement; and iv) providing the rationale for future studies based on early access disease-modifying approaches.

Eligibility criteria:
inclusion criteria: * male and female ≥ 50 years-old with indication of surgery treatment according to local standards for lumbar spinal stenosis (lss) confirmed by mri * availability of the baseline and follow-up annotations * informed consent will be obtained from the patient before any study related procedures exclusion criteria: * previous diagnosis of amyloidosis

Keywords: wild-type ttr amyloidosis lumbar spinal stenosis prevalence