Kornimate/medical-research-clean huggingface dataset:
neuraceq™ pet for detection of brain changes in young athletes post-concussion

Conditions: Concussion, Brain

Summary: the purpose of the study is to learn if neuraceq™ (florbetaben f 18 injection) pet can detect changes in the brains of young athletes who sustained one or more concussions with or without persistent cognitive complaints at least 5 years after injury.

former college athletes who sustained at least one previous concussion will undergo computerized neurocognitive testing and a structured questionnaire of present symptoms. \[f-18\] florbetaben pet images will be acquired dynamically, with data binned in 20 time frames of 1 min each (early phase), followed by 4 frames of 5 min each (late phase), with image frames summed within each phase after linearly coregistering to subjects' mean images, then elastically transformed to template space of a florbetaben scan used in standardized volume of interest quantification, and intensity normalized to mean voxel value within each phase.

Eligibility criteria:
inclusion criteria: * 18-40 years of age * a minimum of 1 concussion prior to study entry * a minimum of one year post first concussion * mtbi as defined by the american congress of rehabilitative medicine * participants in cohort a must have either subjective or objective evidence of persistent cognitive deficits exclusion criteria: * impaired decision-making capacity, i.e. inability to provide informed consent * pregnancy * history of other neurologic disorders (e.g., epilepsy, cerebrovascular disease, neurodegenerative disorders, intellectual disability) * significant systemic medical illness * current dsm-iv axis i diagnosis of psychiatric illness
phase ii trial of regimen for stage iii (n2) nsclc using induction treatment followed by resection

Conditions: Non-small Cell Lung Cancer Stage IIIA

Summary: the investigators hypothesized that the neoadjuvant chemoradiotherapy was a beneficial treatment for patients with stage iiia-n2 non-small cell lung cancer, so we try to evaluate the security of treatment, the qol of patients and the influence to the pfs and os.

scheme: patients will receive different chemotherapy regimens depending on the pathological type. squamous cell carcinoma:docetaxel/cisplatin and concurrent radiation (46gy/23f) followed by surgery, consolidate docetaxel/cisplatin 2 cycles. non-squamous cell carcinoma:pemetrexed/cisplatin and concurrent radiation (46gy/23f) followed by surgery, consolidate pemetrexed/cisplatin 2 cycles.

Eligibility criteria:
inclusion criteria: * 18≤age≤65; * ecog performance status of 0 or 1; * pathological diagnosis with stage iiia-n2 nsclc which is clinically resectable and the n2 is diagnosed by either mediastinoscopy,ebus,pet/ct; * wbc≥4.0×109/l, anc≥1.5×109/l, plt≥100.0×109/l, hb≥90g/l;hepatorenal function is normal; * without a history of other malignancies before enrollment, except for non-melanoma skin cancer, in situ cervical cancer; * the patient can understand the research and sign the informed consent. exclusion criteria: * female in pregnancy or lactating;female of childbearing age without contraception; * with acute infection or other serious underlying disease; * with a significant history of neurological of psychiatric disease，including the dementia which may affect the ability to understand and sign the informed consent; * have received other treatment within the last 30 days before enrollment; * with uncontrollable diabetes(blood glucose is unstable after treatment or fbg≥8mol/l).

Keywords: stage iiia-n2 nsclc
effectiveness of physical therapy on axillary web syndrome after breast cancer surgery

Conditions: Axillary Web Syndrome

Summary: objective: to determine the effectiveness of physical therapy on the axillary web syndrome in improving pain, reducing swelling and increasing mobility of the shoulder. design: randomized single-blinded controlled trial. follow-up: five physical therapy assessments: pre-intervention; post-intervention, 3 months post-intervention, 6 months post-intervention. participants: eighty consecutive women diagnosed with axillary web syndrome after undergoing unilateral breast cancer surgery with alnd or slnd at the prıíncipe de asturias hospital in alcalà de henares, madrid (spain). randomization: women will be randomly assigned to two groups by epidata 3.1 software. interventions: physical therapy group: physical therapy composed of manual lymph-drainage technique in axilla, and proximal ipsilateral arm, specific thumb manual lymph-drainage on the taut cords to make them gradually more flexible, in conjunction with progressive active and action-assisted arm exercises; control group: standard progressive active and action-assisted arm exercises. 9 physical therapy sessions.


Eligibility criteria:
inclusion criteria: * unilateral breast cancer; * breast surgery with lymphadenectomy and / or sentinel lymph node biopsy; * axillary web syndrome in chest and / or upper limb of the operated side; * vas\>3 * consent to participate in the study; * no contraindications for physical therapy (infection, metastasis); exclusion criteria: * cognitive impairment; * visual impairment for reading; * lymphedema; * bilateral breast cancer; * systemic disease (metastases), * infection; * locoregional recurrence.

Keywords: axillary web syndrome cording physical therapy breast cancer
neck exercises, training and pain management as a treatment for whiplash patients with chronic neck pain

Conditions: Neck Pain; Chronic Pain Syndrome

Summary: the purpose of this study is to test whether a physiotherapy intervention containing pain management, general training and specific neck exercises can improve function for patients with chronic neck pain.

neck pain is widespread problem. the prevalence of neck pain in the scandinavian countries is 36%. of the working population the prevalence of chronic neck pain is 10 - 20%.the national board of health estimates that 5-6000 subjects per year in denmark are involved in a traffic accident evoking whiplash-induced chronic neck pain. the main problems for patients with chronic neck pain are cervical dysfunction, reduced neck mobility and stability in addition to local and possibly generalised pain besides chronic neck pain, patients may suffer from poor pain coping strategies and physical inactivity which influences physical function, general health and causes a poor quality of life. physical training including specific exercises targeting the deep postural muscles of the spine is effective in reducing neck pain for patients with chronic neck pain. physical behavioural graded activity is a treatment approach with focus on increasing general physical fitness, reducing fear of movements and increasing psychological function. educational sessions, where the focus is on understanding complex chronic pain mechanisms and development of appropriate pain coping and/or cognitive behavioural strategies have shown reduced general pain. thus this project is formulated on the expectation that rehabilitation of patients with chronic neck pain after a whiplash accident must target cervical dysfunctions, training of physical function and the understanding and management of chronic pain in a combined therapy approach. the study is designed as a randomized control study including 200 patients. all participate in the educational sessions. the training group receives on top of that instruction in specific neck exercises and general training.

Eligibility criteria:
inclusion criteria: * chronic neck pain for at least 6 months * reduced physical neck function (ndi minimum 10) * pain primarily in the neck region, * finished any medical /radiological examinations * able to read and understand danish and * able to participate in the exercise program. exclusion criteria: * radiculopathies upper extremity * neurological deficits * in a process of examining for unknown pathology, * experimental medical treatment, * being in a unstable social situation * pregnancy * fractures * suffering from depression * other known coexisting medical conditions which would severely restrict participation in the exercise program

Keywords: chronic neck pain whiplash whiplash associated disorders chronic pain neck exercises training pacing patient education pain management whiplash injuries musculoskeletal
prospective analysis of introperative regenlab prp and hyaluronic acid in patients with knee acl tear

Conditions: PRP; ACL; Hyaluronic Acid

Summary: purpose: the purpose of this article is to examine the clinical application of prp and prp+hyaluronic acid in disorders in the knee. methods: the study was conducted on 150 adult patients with age over 20 years old affected by unilateral acl complete tear and receiving acl reconstruction. we divided the patients in three groups, and we treated the group a with perioperative injection of hha, group b with perioperative hha+prp, group c with perioperative normal saline. follow-up: every 1,3,and 12months, we recheck physical exmianation at opd and recheck mri at postoperative 3 months.


Eligibility criteria:
inclusion criteria: * receiving unilateral acl reconstruction in our hospital * postoperative follow-up over 3 month exclusion criteria: * postoperative follow-up less than 3 month * possible pregnency * with coagulation disease * nsaids intake during study period

Keywords: prp; acl reconstruction
an observational study evaluating cholesterol levels in patients on cholesterol lowering drugs in jordan and lebanon

Conditions: High Blood Cholesterol

Summary: this was a multicenter survey of patients who were on lipid -lowering pharmacological treatment in 2 levant countries namely jordan and lebanon. the purpose is to study the effects of cholesterol lowering drugs on the blood cholesterol levels of patients in jordan and lebanon. data collected from each patient took place at a single visit. each participating doctor filled the investigator questionnaire on his/her experience and perception of the management of the hypercholesterolemia of his/her patients. each doctor was asked to indicate his/her general attitude on the diagnosis of hypercholesterolemia, the existing guidelines and goals and the various treatment options for high cholesterol in blood. before being assessed by the investigator, patients recorded, on the patient questionnaire, their awareness of high blood cholesterol , their current lipid-lowering treatment schedule, their understanding of their condition and compliance in taking the medications on time. the investigators completed a patient record form (prf) with the patient's basic information, cardiovascular risk factors and the cardiovascular medical history, current lipid lowering drug treatment and the reason for the current therapy. a blood sample under fasting condition was drawn from each subject. a central laboratory in jordan received all samples. every sample was analyzed for its cholesterol blood level, fasting sugar level and hemoglobin a1c levels.

cepheus centralized pan-levant survey on the undertreatment of hypercholesterolemia nis-lt-cre-2010/01 version 1.0

Eligibility criteria:
inclusion criteria: * adult patients with high cholesterol blood levels willing to participate in the study * patients must be on cholesterol lowering medications for three months with no dose change for six weeks exclusion criteria: * patients not on cholesterol lowering medications or on medications for less than three months * any medication dose change in six weeks prior to their visit

Keywords: hypercholesterolemia lipid lowering drugs cholesterol level in blood target cholesterol levels guidelines for the management of high blood cholesterol
tafluprost-timolol fixed dose combination non-inferiority study against concomitant administrations

Conditions: Ocular Hypertension; Open-angle Glaucoma

Summary: the purpose of this study is to compare the efficacy and safety of the preservative-free fixed-dose combination of tafluprost and timolol (fdc) to concomitant administration of tafluprost and timolol. this study will enroll patients who have ocular hypertension or glaucoma. the study schedule includes seven visits to the study site and three stages: * washout of 5 days to 4 weeks depending on current glaucoma medication (if any) * 6-month study treatment period * 1-3 weeks post-study period


Eligibility criteria:
inclusion criteria: * aged 18 years or more * a diagnosis of ocular hypertension or open-angle glaucoma * meet specific iop level at visit 1 (screening)and visit 2 (baseline) * meet specific visual acuity score * are willing to follow instructions * have provided a written informed consent exclusion criteria: * females who are pregnant, nursing or planning pregnancy * iop greater than 36 mmhg at any time point at screening or baseline * diagnosis of angle-closure glaucoma or secondary glaucoma other than capsular or pigmentary glaucoma in either eye * suspected contraindication or hypersensitivity to study medications tafluprost or timolol (e.g. asthma, low pulse) or to wash-out medication brinzolamide * glaucoma filtration surgery or any other ocular surgery (including ocular laser procedures) within 6 months prior to screening * use of contact lenses at screening or during the study * presence of any abnormality or significant illness that could be expected to interfere with the patient safety or study parameters * current participation in another clinical trial within the last 30 days
feasibility of radioisotope-guided excision of mediastinal lymph nodes in patients with non-small cells lung carcinoma

Conditions: Lung Cancer

Summary: non-small cells lung carcinoma (nsclc) represents one of the most common and lethal neoplasms. nsclc is characterized by an early asymptomatic phase, which hinders the disease identification in its earliest stages. as a consequence, nsclc is often diagnosed at a clinical stage when the potentially curative surgical approach is challenging. in general, nsclc up to the tnm stage ct3n2m0 are considered operable; in particular, nodal localizations in the homolateral hilus (n1) and underneath the carina (n2) are considered surgically manageable. identification of nodal disease on the pre-operative pet/ct does not guarantee that all disease-bearing lymph node will be retrieved in the course of the open operative procedure. smaller nodes might be challenging to identify; moreover, the co-existence of macroscopic and microscopic disease might hinder the radicality of the surgical intervention. this process can be tracked using specific radioactive radiopharmaceuticals, such as radioisotope-labelled colloids, which can be injected in the immediate proximity of the primary and then travel toward the closest cluster of mediastinal lymph nodes. there, they are incorporated in the nodal structure and progress no farther. by employing a radioisotope probe during surgery, all of the first-line nodes (so-called sentinel lymph node, sln), which receive the lymphatic flow from the tumor region directly, can be identified. the hypothesis of the investigators is that, by performing a radioisotope sln mapping intraoperatively, the surgeons will be able to detect the metastatization process more accurately than relying on pre-operative imaging alone. the present study will be a prospective and monocentric trial. clinical, histological, and imaging data collected from examinations performed according to the good clinical practice will be analyzed. the estimated duration of the study is 12 months. it will include the prospective inclusion of patients with a diagnosis of operable nsclc, who will receive a surgical treatment with curative intent at the investigators' institution (ich).


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * newly diagnosis of stage i-iiia nsclc (higher stage could be considered, pending a multidisciplinary evaluation and approval). * baseline 18ffdg-pet-ct and cect * treatment according to good clinical practice exclusion criteria: * unavailability of baseline images * diagnosis other than nsclc at definitive pathology * surgery carried without complete resection or with no curative intent
the prevalence of secondary adrenal insufficiency in patients with exacerbation of copd in glucocorticoid treatment related to differenct gene polymorphisms of the glucocorticoid receptor gene

Conditions: Adrenal Insufficiency

Summary: to investigate the correlation between four well-known polymorphisms of the glucocorticoid receptor gene (two with reduced sensitivity versus two with increased sensitivity) and the prevalence of secondary adrenal insufficiency in glucocorticoid-treated patients with exacerbation of copd.

copd patients who have received systemic glucocorticoid exceeding the equivalent of 180 mg prednisolone which are homo / heterozygous for the bcli and / or n363s polymorphisms (associated with increased glucocorticoid sensitivity) will have a lower cortisol response in a synacthen® test (greater suppression of adrenal corticosteroid) than the corresponding patients there are wild-type or homo- or heterozygous for the polymorphic er22 / 23ek and / or 9β (associated with decreased sensitivity). information from the results of the investigation will be able to help clinicians to identify patients with acute exacerbation of copd (aecopd) at risk of of secondary adrenal insufficiency.

Eligibility criteria:
inclusion criteria: * adult patients \> 18 years * caucasian classified with copd * patients with aecopd being treated with at least 5 days of glucocorticoid (minimum of 180 mg) exclusion criteria: * treated with estrogen-containing medications, including anticonceptiva 6 weeks prior to synacthen® * pregnancy or lactation * on regular systemic glucocorticoid therapy before admission to the hospital * people who are detained under the act on the use of coercion in psychiatry * severe language problems or inability to provide written informed consent
red cell mass and plasma volume measurements in elderly men and women with anemia

Conditions: Anemia

Summary: on the basis that the clinical consequences of seemingly trivial levels of anemia are surprisingly severe, this study investigates if hemoglobin concentration accurately represents the underlying red cell mass in elderly patients with unresolved anemia.

for the study, the routine clinical measurement of hemoglobin will be compared to true red cell mass and plasma volume in elderly patients with anemia.

Eligibility criteria:
inclusion criteria: * 65 and older * anemia (hemoglobin \< 13 g/dl in men or \< 12 g/dl in women) * outpatient at either the stanford health care (shc) medical center or va palo alto health care system exclusion criteria: * body mass index (bmi): * \< 18.5 kg/m2 * \> 35 kg/m2 * palpable splenomegaly * contraindication to rbc mass/plasma volume testing * on any experimental pharmacologic agent in the prior 2 months
comparison of efficacy of microneedling with platelet rich plasma vs microneedling with topical insulin in the treatment of acne scars

Conditions: Post-acne Atrophic Scars

Summary: this study compares the outcome of two procedures for the treatment of atrophic acne scars.

post acne scars develop due to severely inflamed and nodulocystic acne. numerous methods exist for the treatment of post acne scars including lasers , microneedling and chemical peels etc . this study is to compare the efficacy two procedures.

Eligibility criteria:
inclusion criteria: patients confirmed with post-acne atrophic scars . no prior treatment for scars in last 6 months. - exclusion criteria: * patient with active acne or other skin conditions (e.g eczema , psoriasis). patients on oral or topical retinoids. pregnant or lactating mothers. patients with recurrent herpes simplex infection. previous hx of keloids / hypertrophic scarring. deranged blood glucose levels. bleeding disorders

Keywords: post-acne atrophic scars microneedling with autologous platelet- rich plasma microneedling with topical insulin
evaluation of the impact of water access and promotion in parks on beverage intake

Conditions: Obesity

Summary: sugar-sweetened beverages (ssbs) are a major caloric source and the largest source of added sugars in the american diet. while many cities around the country have adopted anti-ssb policies such as soda taxes to reduce ssb intake, there has yet to be any studies to evaluate if the effects of these taxes, coupled with increased water access and promotion effort can lead to decreased sugar sweetened beverage consumption and increased water consumption. this quasi-experimental study evaluates how implementation of ssb taxes, installation of new water stations, and a multicultural water promotion campaign in parks impacts beverage intake in these settings as compared to soda taxes alone.

consumption of water, in place of sugar sweetened beverages (ssbs), can help prevent obesity and dental carries. while drinking water is associated with these and many other positive health outcomes, many do not meet the recommended dietary intake of water. this is more profound in low income and minority communities that are more likely to drink less water and drink more ssbs. school-based water promotion interventions have shown that improved access to clean drinking water coupled with promotion leads to increases in water consumption and improved health outcomes. no studies have studied the impact of similar strategies on beverage intake and health in parks and public spaces. parks are an inconspicuous and widely utilized public space, with the majority of americans going to a park in the last month. this study's central hypothesis is that visitors in parks with ssb taxes coupled with increased access to appealing drinking water and rigorous promotion of its consumption will be more likely to drink water and less likely to drink ssbs, compared to visitors in parks with only ssb taxes. this quasi-experimental study makes use of naturally-occurring policy changes in the san francisco (sf) bay area to disentangle the impacts of anti- ssb policies, water station installation, and multicultural water promotion efforts, using control groups to isolate the effects of anti-ssb policies alone or no intervention. this study will analyze beverage consumption in 10 sf parks that received new water stations and a multicultural water promotion campaign compared to 20 matched control parks (10 parks sf and 10 parks in oakland) with only ssb taxes.

Eligibility criteria:
inclusion criteria: * park visitors within a defined geographic boundary exclusion criteria: * park visitors outside a defined geographic boundary

Keywords: water parks public spaces sugar-sweetened beverages