Kornimate/medical-research-clean huggingface dataset:
sleep hygiene intervention on sleep quality improvement in elders with parkinson's disease

Conditions: Sleep Disorder

Summary: sleep disorders (sds) are one of the most frequent non-motor symptoms of parkinson's disease (pd), usually increasing in frequency over the course of the disease and disability progression. sds include nocturnal and diurnal manifestations such as insomnia, rem sleep behavior disorder, and excessive daytime sleepiness. the causes of sds in pd are numerous, including the neurodegeneration process itself, which can disrupt the networks regulating the sleep-wake cycle and deplete a large number of cerebral amines possibly playing a role in the initiation and maintenance of sleep.

sleep disorders (sds) constitute the second most frequent complaint, affecting 64% of pd patients, ranging from 41.1% in naïve patients to 78.3% in complicated patients. sds in pd are multifactorial and include nocturnal and diurnal manifestations. reduced sleep efficiency and an increased number of awakenings characterize sleep in pd. these disturbances are linked, on one side, to pd motor (akinesia, rigidity, and dystonia) and autonomic symptoms (nocturia) and, on the other side, to the presence of concomitant sds such as rem sleep behavior disorder (rbd), restless legs syndrome (rls), or breathing disorders such as obstructive sleep apnea (osa). diurnal manifestations include excessive daytime sleepiness (eds) and sudden sleep attacks, which could be a consequence of nocturnal sleep impairment or dopaminergic treatment or, more interestingly, to the neurodegenerative process of pd itself dysregulating the circadian sleep-wake rhythm.

Eligibility criteria:
inclusion criteria: * elderly individuals aged 60 years or older, with a confirmed diagnosis of parkinson's disease. * cognitively and physically able to engage in the study. exclusion criteria: * participants using sedative medications .

Keywords: sleep sleep hygiene sleep quality aged parkinson's disease quasi-experimental design
resilience and brain health of older adults (medex-2)

Conditions: Age-related Cognitive Decline

Summary: this project capitalizes on a natural experiment imposed by the covid-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. this project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of alzheimer disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.


Eligibility criteria:
inclusion criteria: * participated in the parent study, protocol id #201410093 exclusion criteria: * inability to safely continue classes or complete assessments, as per pi discretion

Keywords: exercise mindfulness education elderly
anger control therapy (act) with rage-control: an outpatient videogame-assisted therapy for the treatment of anger

Conditions: Anger; Aggression

Summary: the purpose of this study is to determine whether adding an interactive biofeedback video game to anger control cognitive behavioral therapy is an effective and feasible treatment.

current treatments for pathological anger and aggression in youth are lacking in their effectiveness to motivate and engage patients in treatment. as a result, mental health providers encounter challenges due to the limited generalizability of treatment effects to real-world situations outside of the therapist's office. when behavioral treatments fail to show lasting results, children and adolescents are often placed on antipsychotic medication to control their behaviors, which may result in significant toxicity levels and for which there is limited knowledge of the long-term effects on pediatric growth and development. this study tests an interactive biofeedback video game called rage-control (for regulate and gain emotional-control) as a treatment for youth exhibiting anger and aggression. treatment with rage-control seeks to motivate children and adolescents to learn and practice coping skills taught in therapy within the environment of a fun and enjoyable video game. the game provides patients a venue to practice self-regulation techniques in response to the increasing stress of the game. providing patients with the opportunity to refine their self-regulation skills in a fast-paced challenging game is hypothesized to result in greater generalization of therapeutic skills to situations outside of the therapist's office. the goal of the treatment is to decrease patients' feelings of anger, and to increase the patients' levels of control in their emotional and behavioral responses.

Eligibility criteria:
inclusion criteria: * ages 10 to17 years old (inclusive). * staxi-ca score \>15 on the trait anger subscales. exclusion criteria: * inability to consent, comprehend, or effectively participate in the study. * cognitive impairment, defined as iq \< 75. * change in mood stabilizing and/or anti-psychotic medication dose within 4 weeks of beginning the study or anticipation of medication changes during the study period (10 weeks).

Keywords: anger aggression biofeedback videogame
bremen eye drops versus combigan for open-angle glaucoma or intraocular hypertension

Conditions: Ocular Hypertension; Primary Open-angle Glaucoma

Summary: the purpose of this study is to evaluate the clinical efficacy of the bremen eye drops in the treatment of primary open-angle glaucoma or intraocular hypertension.


Eligibility criteria:
inclusion criteria: * signed consent; * participants with diagnosis of open-angle glaucoma or hypertension ocular, who needs treatment with drugs association to control the intraocular pressure; * participants who have 20/80 visual acuity or more, in both eyes; exclusion criteria: * participants with any clinical significant disease that, after evaluation of the investigator, can´t participate in the study; * participants with active eye disease, which in the investigator opinion may interfere in the results of this clinical trial; * participants presenting previous diagnosis of non-operated cataract, high myopia, high astigmatism, pseudoexfoliation and corneal deformities; * participants who had significant visual loss in the last year; * treatment-naive participants for open-angle glaucoma or ocular hypertension; * participants nonresponders to previous triple combination drug therapy, used in concomitance; * participants with previous ocular or intraocular surgery within six months prior to enrollment in the clinical trial; * participants with history of hypersensitivity to any formula compounds; * participants presenting contraindications to use of beta-adrenergic antagonists; * participants diagnosed with uncontrolled cardiovascular disease; * participants with severe renal insufficiency or hyperchloremic acidosis; * participants in therapy with monoamine oxidase inhibitors (maois); * participants who were in use of drugs that can interfere in the evaluation; * pregnancy or risk of pregnancy and lactating patients; * alcoholism or illicit drug abuse in the last two years; * participation in clinical trial in the year prior to this study.
life-long monitoring of frail patients with chronic diseases

Conditions: Multiple Chronic Diseases Among Diabetes Mellitus, Chronic Obstructive Pulmonary Diseases and Heart Failure

Summary: the purpose of this study is to evaluate whether telemonitoring of frail patients with chronic diseases produces benefits in terms of reduced readmissions, improved health related quality of life, and improved health status. in addition, the trial evaluates the economic and organisational impact of the telemonitoring service and examines its acceptability by patients and health professionals.

the study is designed to evaluate the impact of telemonitoring on the follow-up of elderly patients with one or more chronic diseases among heart failure, chronic obstructive pulmonary disease and diabetes. the particular target of patients selected has the particularity of being "frail" according to a set of social eligibility criteria, agreed by the clinicians participating at the study. general practitioners are the first clinicians in charge of managing these patients during the trial follow-up. the term of comparison is represented by a control group, followed by outpatient usual care. from a clinical point of view, the trial will investigate how the remote monitoring of some clinical parameters contributes to reduce the access to healthcare facilities (emergency and planned hospitalization, bed-days, er, specialist and gp visits), to improve the patients health-related quality of life and to reduce the anxiety about health conditions. a cost-effectiveness and cost-utility analysis will be carried out in order to determine if and how telemonitoring helps to limit the healthcare expenditure. the evaluation will deal also with organizational changes and task shift due to telemonitoring introduction and patients and professionals perception towards the service.

Eligibility criteria:
inclusion criteria: * age ≥ 65 years * diagnosis of one or more of the following chronic diseases: * heart failure - diagnosis confirmed by echocardiogram or by a specialist assessment * type 1 or 2 diabetes - with hba1c of 7.5 or greater in the previous 15 months * chronic obstructive pulmonary disease (copd) - diagnosis confirmed by spirometry and fev1 ≤ 70% of predicted normal and/or fev1/fvc ratio ≤ 70% or by a specialist assessment * and at least one of the following social inclusion criteria: * have had a fall in the previous year or who are considered at high risk of falling * need home social care * have a caregiver who have difficulties to take care of him/her properly * cognitive impairment/confusion, but with caregiver able to use devices. exclusion criteria: * patient unable to use the telemonitoring equipment (alone and assisted)
locomotor learning in infants at high risk for cerebral palsy

Conditions: Cerebral Palsy

Summary: the objective of this project is to characterize the evolution of locomotor learning over the first 18 months of life in infants at high risk for cerebral palsy (cp). to characterize how locomotor skill is learned (or not learned) during this critical period, the investigators will combine established protocols using robust, unbiased robotic and sensor technology to longitudinally study infant movement across three consecutive stages during the development of impaired human motor control - early spontaneous movement, prone locomotion (crawling), and upright locomotion (walking).

early spontaneous leg movements will be measured monthly from 1-4 months of age. infants who remain at high risk for cp by month 4 as measured by the general movements assessment and the test of infant motor performance (timp) at 4 months of age will continue to locomotor training phases. prone locomotor training using the self-initiated prone progression crawler (sippc) will be delivered from 5-9 months of age. upright locomotor training with dynamic weight support (dws) will be delivered from 9-18 months of age. repeated assessments of locomotor skill, movement quality, training characteristics, and variables that may mediate locomotor learning will be collected at time points from 1 month to 18 months of post-term age. investigators will examine the relationships between motor error and locomotor skill acquisition over time, anticipating that experiencing and correcting movement errors is critical to skill acquisition in infants at risk for cp; the contribution of other training characteristics (movement time, movement variability, and postural control) to locomotor learning; and how learning is mediated by neurobehavioral factors outside of training. investigators will develop comprehensive models of training predictors and mediators for prone and upright locomotor learning.

Eligibility criteria:
inclusion criteria: * less than 6 weeks of age (corrected for prematurity, if applicable) * have a history of an early brain injury associated with high risk for cerebral palsy including periventricular leukomalacia, hypoxic-ischemic encephalopathy, intraventricular hemorrhage, hydrocephalus, stroke, neonatal seizures, or intracranial cystic lesion * family is able to commit to study visits exclusion criteria: \* known genetic condition unrelated to cerebral palsy (cp) or congenital abnormalities infants with fidgety movements on the general movements assessments (gma) at 3 months of age or a score greater than -0.5sd below the mean on the test of infant motor performance at 4 months of age will not progress in the study because these infants are unlikely to have cp.

Keywords: cerebral palsy infant physical therapy motor learning robotics
ip2p mentorship program for teen hf patients

Conditions: Heart Failure

Summary: the ipeer2peer (ip2p) program is an online peer support mentorship program that provides modelling and reinforcement by trained young adult peer mentors to adolescent mentees with the same condition. a waitlist hybrid implementation-effectiveness type 3 pilot randomized controlled trial design will be employed across four sites. we will recruit 40 mentees (12-17 years of age) and 12-15 mentors (18-25 years of age) who will undergo training in mentoring and the use of ehealth technology. mentor-mentee pairings will connect over 15 weeks through video calls and text messaging to provide peer support and encourage disease self-management skills. data will be collected using standardized instruments and interviews across three time points.


Eligibility criteria:
mentee inclusion criteria: 1. patient with a cardiac diagnosis, 2. at least 4 months post-diagnosis, 3. between the ages of 12 and 17 years, 4. able to speak and read english, and 5. willingness to commit to 5-10 texts and/or calls of 20-30 minutes each with a peer mentor over a period of 15 weeks. mentor inclusion criteria: 1. patient with a cardiac diagnosis, 2. between the ages of 18 and 30 years, 3. able to speak and read english, 4. nominated by a member of their health care team as a good mentor based on maturity and emotional stability, 5. willingness to commit to peer mentor training (20 hours) via the phipa-compliant version of zoom or microsoft teams and mentoring adolescent participants (once paired with mentee, 5-10 texts and/or calls of 20-30 minutes over a period of 15 weeks), 6. good communication skills (as assessed by a healthcare provider), and 7. previous experience in a professional environment (e.g., as a camp counsellor, part time job, volunteering) is an asset. exclusion criteria: 1. significant cognitive impairments as assessed by a qualified healthcare provider, 2. a diagnosis of an active psychological disorder (e.g., major depressive disorder, generalized anxiety disorder) likely to influence assessment of health-related quality of life and/or interfere with their ability to manage their heart failure care regimen (a diagnosis of an active psychological disorder will be determined for mentees through medical chart review and self-reported by mentors), and 3. participating in other peer support or self-management interventions.

Keywords: peer support mentorship pediatrics adherence cardiomyopathy
exploration of gemfibrozil as a treatment for aud

Conditions: Alcohol Use Disorder

Summary: this study will examine the efficacy of the medication gemfibrozil in reducing alcohol consumption in individuals with an alcohol use disorder who are seeking treatment for alcohol-related problems. twenty individuals will be randomized to receive four weeks of either gemfibrozil or placebo and retrospective reports of alcohol use will be collected throughout the trial. in addition, brain imaging measures will be collected at baseline and after two weeks of treatment to determine the effects of gemfibrozil on brain functioning.


Eligibility criteria:
inclusion criteria: 1. males and females age 18-60 meeting dsm-v criteria for moderate or severe aud in the past year 2. interested in cutting down or quitting drinking 3. able to provide voluntary informed consent 4. have at least 4 heavy drinking days (≥ 5 drinks per day for men, and 4 for women) in the past 30 days exclusion criteria: 1. severe liver disease; severe kidney disease; gallbladder disease or gallstones 2. chronic renal or hepatic failure 3. recent pancreatitis 4. insulin-dependent diabetes 5. other urgent medical problems 6. moderately elevated liver function tests (ast or alt greater than 2 times upper limit of normal) or elevated creatine kinase (ck) 7. schizophrenia, schizoaffective disorder, bipolar i disorder, suicidal thoughts in the last month 8. current moderate or severe other substance use disorder (sud; except nicotine or marijuana) 9. active legal problems with the potential to result in incarceration 10. pregnancy or lactation, or child bearing age and not on birth control or not willing to use other birth control methods (e.g. condoms) 11. current daily use of anti-craving medications, mood stabilizers, benzodiazepines, or anti-psychotics 12. regularly taking a medication contraindicated for use with gemfibrozil including other fibrates, statins, repaglinide, or which are believed to interact with gemfibrozil such as dasabuvir, dabrafenib, loperamide, montelukast, paclitaxel, pioglitazone, rosiglitazone, colestipol, colchicine and warfarin41,68 13. a history of alcohol withdrawal-induced seizures or delirium tremens (hallucinations, disorientation) requiring hospital admission during the last ten years 14. a history of moderate or severe traumatic brain injury (tbi; loss of consciousness \>30 minutes69) 15. left-handedness 16. any contraindications for mri
brief physical activity intervention for older people with multimorbidity

Conditions: Chronic Conditions, Multiple; Old Age; Debility; Physical Inactivity

Summary: physical activity is an important determinant of health and well-being in older people. however, many older people do not achieve recommended physical activity levels and increasing older people's physical activity is challenging. this preliminary study will explore the effects of a brief physical activity intervention on physical activity and physical function in older people with multimorbidity. the findings will be used to inform the design of a subsequent adequately-powered randomised controlled trial.


Eligibility criteria:
inclusion criteria: * aged ≥60 years * 2 or more chronic conditions * able to walk outside the home * able to attend the study visits exclusion criteria: * living in a residential or nursing home * housebound * ≥3 falls in previous year * dementia or significant cognitive impairment (unable to follow simple instructions) * contraindication to increasing physical activity * unable to read or speak english * unable to provide consent * no more than one person per household

Keywords: multimorbidity older people physical activity
chain1 : dental wear and musculoskeletal disorders - association?

Conditions: Tooth Wear; Musculoskeletal Disorder

Summary: this study aims to explore the relationships between tooth wear (tw) and musculoskeletal disorders (msds). the null hypothesis is that tw is not associated to msds. it also explores the influence of bruxism signs, life habits and stress on tw and msds.

this study is based on questionnaires and clinical examination performed by a dentist.

Eligibility criteria:
inclusion criteria: * between 18 and 80 years old * have the mental abilities to participate in study * understand the language of the survey (french) * sign free and informed consent exclusion criteria: * consult for a painful dental emergency * do not have at least 8 teeth per maxilla, with natural dental tissues in contact with the antagonistic teeth * being in the process of an orthodontic treatment * wear of a bimaxillary orthognathic nightguard

Keywords: tooth wear musculoskeletal disorders
comparative psychiatric problems between first and second trimester miscarriage

Conditions: Abortion

Summary: description of the psychiatric impact of miscarriage on women.

miscarriage, a significant reproductive health issue, often has profound psychological implications for women. the emotional and psychiatric effects of abortion can vary widely based on individual, cultural, and situational factors, as well as the timing of the procedure (1). first-trimester abortions are typically more common and are generally less complex medically, while second-trimester abortions often involve more intricate decision-making processes and greater societal and personal stigma (2). emerging evidence suggests that women undergoing abortions in different trimesters may experience distinct psychiatric challenges, including anxiety, depression, and post-traumatic stress disorder. however, the comparative psychological burden between first- and second-trimester abortions remains underexplored (3-6). understanding these differences is crucial for tailoring mental health interventions and providing comprehensive care to affected women. this study aims to compare the prevalence and types of psychiatric problems in mothers undergoing abortion in the first versus the second trimester, thereby contributing to the body of knowledge on maternal mental health and informing evidence-based support strategies.

Eligibility criteria:
inclusion criteria: * all miscarrying women less than or equal to 26 weeks gestation exclusion criteria: * ectopic pregnancy and vesicular mole

Keywords: abortion
nationwide study of artificial intelligence in adenoma detection for colonoscopy

Conditions: Colonic Polyp; Colonic Adenoma; Colo-rectal Cancer

Summary: the goal of this trial is to determine whether use of a computer assisted detection (cade) programme leads to an increase in adr for either units or individual colonoscopists, independent of setting or expertise

this is a case-control study comparing adenoma detection rate (adr) in hospitals (and individual colonoscopists), before, during and after use with an artificial intelligence unit called gi genius™ (gig). gig is a computer-assisted detection (cade) module that assists the human colonoscopist in real-time, by detecting and marking out polyps during colonoscopy. it has been shown to be effective in expert colonoscopists, but the effect in non-expert, general, colonoscopists is not known. the investigator wish to deploy gig into colonoscopy through the uk using a step-wedge design. sites will be randomly allocated a start date for gig deployment, collecting data for four months prior to this. in this way, all sites will have the active intervention and will provide their own case-control data. (4 months collection prior to activating gig, 4 months with gig, 4 months afterwards without gig) the study will concentrate on non-expert colonoscopists, to determine whether gig can increase adr. patients will undergo the same colonoscopy that they would have had in any case, with no additional trial visits or interventions. there will be no alteration to the usual care pathway from the patient's perspective. if the investigator can prove gig increases adr in this way, it will provide support to roll out this technology routinely to improve the quality of colonoscopy nationwide.

Eligibility criteria:
inclusion criteria: * any patient aged 18-85 scheduled for colonoscopy by current nhse / british society of gastroenterology criteria exclusion criteria: * colonoscopy being performed for polyp surveillance * unable to provide informed, written consent

Keywords: artificial intelligence computer assisted detection (cade) colorectal cancer adenoma detection rate (adr)