Kornimate/medical-research-clean huggingface dataset:
assessment of performance and safety of an asymmetric balloon in the treatment of intranasal bleeding managed in an emergency setting

Conditions: Epistaxis

Summary: between 10 and 12% of the general population suffers from epistaxis, out of which 10% would need to be medically managed. most of patients treated for epistaxis are managed through emergency departments. the involvement of the ent (ear, nose and throat) surgeon might be required in more complex situations in order to control bleeding. usually, nasal packing packing is used as a first line option after failure of digital compression. epistaxis balloons are often used after failure of nasal packing balloons are effective in approximately 60% of the patients with a rapid control of bleeding by compression followed by an absence of rebreeding after balloon removal. the main challenges for patients treated with this device are i) pain upon balloon introduction and inflation ii) discomfort upon introduction in the nasal cavity as well as during balloon maintenance during 24 to 72 hours of tamponade iii) blood retention between distal and proximal balloons that favors infection iv) limited breathing capabilities through the nostrils which increases general discomfort v) negative aesthetic impact for the patient vi) septal and alar necrosis risk in case of prolonged compression. moreover, epistaxis leading to an hospitalization between 24 to 48h are not rare (\>11 000 in france in 2017 according to atih). those hospitalizations are often decided in order to ensure an optimal patient monitoring following packing or epistaxis balloon placement. in order to address those adverse events while keeping the same efficacy and avoiding hospitalizations or reducing their duration, the use of an asymmetric, more physiological, easy to use and mainly intranasal (discreet proximal extremity) is studied.


Eligibility criteria:
inclusion criteria: * age \> or = 18 years * male and female * bleeding uncontrolled with digital compression * patient registered at social security * patient who gave informed consent exclusion criteria: * allergy to xylocaine * impossibility to give patient information (severe massive epistaxis, difficulty to understand, non awaken patient...) * patient in custody of court * patient under guardianship or curator
activating media for salt reduction

Conditions: Hypertensive Disease

Summary: mass media plays more and more important role in health education, especially in some chronic diseases which related closely with the behavior and habits. past experience tells us that with the help of related health education in mass media such as newspaper articles, advertisements and videos on television, peoples can change their behaviors and habits in a short period of time. but when these educational information were stopped, peoples usually return to their original habits. besides the national policy of the country how to improve the long-term health education in the mass media should be considered.this study hopes to seek an effective method to keep the mass media long-term focus on health education.

in this study, reporters just like researchers were in charge of the low-sodium salt intervention. reporters are responsible for recommended objects and measure their blood pressure personally. by observing personally the change of blood pressure pre and post low-sodium salt intervention, reporters will increase their confidence and come to the conclusion that the low salt diet is an economical way to reduce blood pressure. those reporters would share their experiment with other people including their colleagues, hopefully, those reporters that took part in the trial would consciously keep a sustained focus to this topic, thereby retaining a long-time education in mass media.there were two interventions. one is low-sodium salt intervention and the other is informational intervention. low-sodium salt intervention was carried out on those family members recommended by reporters, and informational intervention. low-sodium salt intervention was only on the reporters. the evaluation criteria of low-sodium salt intervention is the blood pressure value, and the evaluation criteria of informational intervention are the numbers of related articles in certain newspaper and the awareness of related knowledges in local population.

Eligibility criteria:
inclusion criteria: * come from local only daily company; * with a national press card; * health column reporters preferred; * without leaving plan in the next 12 months; * with easy access to at least 4 families, including relatives, friends or neighbour; * volunteered to participate. exclusion criteria: * n/a

Keywords: low sodium salt blood pressure reporter
gait analysis of anterior versus posterior approach in performance of total hip arthroplasty

Conditions: Osteoarthritis

Summary: the primary objectives of the study is to compare gait kinematics and the return to normalization of gait in patients that have undergone a total hip arthroplasty (tha) via the direct anterior approach versus the posterior approach. gait kinematics will be measured using the ideea lifegait device from minisun (fresno, ca).

this is a prospective study of two different surgical approaches to tha, direct anterior vs posterior approach in approximately 64 patients that meet the standard criteria for the implantation of primary total hip replacement utilizing the medacta implants and have elected to undergo tha.

Eligibility criteria:
inclusion criteria: * patients fulfilling the standard criteria for the implantation of primary total hip arthroplasty * those presenting with primary or secondary osteoarthritis * those presenting with disease that meets the indications for use for medacta usa implants defined by this study (on-label use) exclusion criteria: * pregnant women or women who plan to conceive within the year following surgery * inflammatory arthritic condition * those whose prospects for a recovery to independent mobility would be compromised by known coexistent, medical problems * those already treated with a failed total hip arthroplasty (tha) * muscle contracture around the hip joint * individuals who have undergone organ transplant * those with a known co-existent medical condition where death is anticipated within five years due to the pre-existing medical condition. * those with one or more medical conditions identified as a contraindication defined by the labeling on any medacta implants used in this study * individuals who have had a tha on the contra-lateral side within the 6 months. * individuals who have undergone a thr on the contra-lateral side and whose outcome is considered unsatisfactory or not good * individuals requiring bilateral hip replacement * individuals whose body mass index (bmi; kg/m2) \>40 * individuals with active or suspected infection or sepsis * individuals with chronic renal failure as defined by the need for dialysis * patients with severe forms of developmental dysplasia of the hip (ddh): crowe types ii, iii, iv * history of drug and/or substance abuse
prucalopride effects on subjects with chronic non-cancer pain suffering from opioid induced constipation

Conditions: Non-cancer Pain; Opioid Induced Constipation

Summary: the study will evaluate the efficacy, safety and tolerability of prucalopride over 12 weeks of treatment in subjects aged 18 years and older with chronic non-cancer pain, suffering from opioid induced constipation.


Eligibility criteria:
inclusion criteria to be assessed at screening: 1. male or non-pregnant, non-breast-feeding female outpatient ≥18 years. 2. has chronic pain of any aetiology (except cancer pain) requiring daily maintenance treatment with opioids;has been on stable daily opioid dose during at least the previous 2 weeks; and is expected to remain on stable daily dose of opioids for at least 15 weeks after visit 1. 3. subject is suffering from oic (i.e. secondary to chronic opioid use). 4. subject agrees to stop his/her laxative treatment and is willing to use rescue medication. main exclusion criteria to be assessed at screening: 1. constipation is thought to be drug-induced (except for opioids) 2. disallowed medication is being used 3. subject was on chronic therapy for chronic constipation prior to start of opioid therapy 4. subject is suffering from secondary causes of chronic constipation.

Keywords: opioid induced constipation/prucalopride chronic non-cancer pain subjects with chronic non-cancer pain suffering from oic
the inside study: oligosaccharides versus placebo in functional constipation

Conditions: Functional Constipation

Summary: in the present randomised double blind controlled study, the investigators will study the effects of oligosaccharides vs a placebo on the change in stool consistency and stool frequency in children with functional constipation.

functional constipation (fc) in children is a common gastrointestinal (gi) disorder with a worldwide prevalence ranging from 0.7% to 29.6%. complaints include infrequent bowel movement, painful defecation due to hard and/or large stools, fecal incontinence, and abdominal pain. although the condition is rarely life-threatening, it strongly impairs quality of life. oligosaccharides have been shown to relieve constipation symptoms in young adults and elderly. however, sufficient evidence is lacking linking oligosaccharides intake to improve symptoms in children with fc. the investigators hypothesize that oligosaccharides might be able to relieve symptoms of constipation in young children as well, among which softening stools.

Eligibility criteria:
in order to be eligible to participate in this study, a subject must meet all of the following criteria, as considered by a medical doctor: * written informed consent * aged 1-3 years * children that meet the rome iv criteria for functional constipation exclusion criteria: a potential subject who meets any of the following criteria will be excluded from participation in this study: * children who suffer from any other gi complaints than functional constipation, known structural gi abnormalities, or previous gi surgery * any condition that would make it unsafe for the child to participate. * children with clinically significant cardiac, vascular, liver, pulmonary, psychiatric disorders, severe renal insufficiency, human immunodeficiency virus, acquired immunodeficiency syndrome, hepatitis b or c or known abnormalities of haematology, urinalysis, or blood biochemistry * children who are allergic to cow's milk or fish * use of antibiotics or other medicines or food supplements, and breast milk-feeding, 4 weeks prior to the study, except for the allowed escape medication * children that participate in another clinical trial

Keywords: oligosaccharides
radiofrequency nerve ablation versus sham to treat chronic low back pain caused by sacroiliac joint dysfunction

Conditions: Sacroiliac Joint Dysfunction

Summary: trial will enroll qualified subjects at a 2:1 ration to receive radiofrequency ablation or sham. at six weeks follow up they will be unblinded; sham subjects will then be given option to receive treatment. subjects will be followed after procedure for data collection for economic outcomes and efficacy of treatment.

patients presenting with low back pain associated with sijd for longer than 6 months, and who have not had positive responsive to the conservative treatments: * pharmacologic management * therapies; physical, acupuncture, massage etc... * other alternative treatments enrollment, treatment/sham procedure, follow-up at 3 weeks, 6 weeks with unblinding, 4, 6, 9 months. un-blinding occurring at 6 weeks with crossover option to receive treatment. total visits 7 with enrollment approximately over a period of 9 months. trial extension optional for phone contact at year 1, 2. sham subjects receiving treatment will be followed at months 6 weeks, 4, and 6 months with phone calls at year 1, 2. patients who complete at least 50% of their patient diaries, and miss no more 2 consecutive office visits. data will be used if patients have remained enrolled thru 4 month visit.

Eligibility criteria:
inclusion criteria: * 1. 18 years old, or older 2. unilateral or bilateral lbp or buttocks pain for greater than six months with a 3 day average vas greater or equal to 4 on a 1-10 scale 3. tenderness over the si joint 4. 75% or greater relief of pain (with return to baseline) during the local anesthetic phase of two separate, one fluoroscopically guided intra-articular si joint injection and one lateral branch block (see appendix a) 5. stable medications for pain for the last seven days 6. have used at least 3 alternative treatments for pain without success (se 7. bmi less than 35.0 exclusion criteria: 1. focal neurologic signs 2. any component of pain related to lumbar z-joints at l4-5 and/or l5-s1 as determined by one set of medial branch blocks 3. previous radiofrequency procedure within the last 6 months 4. moderate or greater spinal stenosis 5. greater than grade 2 listhesis 6. foraminal stenosis; marked to severe 7. previous lumbar spine surgery 8. unstable medical or psychological conditions as determined by the investigator 9. concomitant cervical or thoracic pain greater than 2/10 on vas 10. workers compensation, disability or litigation 11. pregnancy, breast feeding or planning on becoming pregnant during the trial 12. subject unwillingness to complete study related activities 13. current smoker; unless quit greater than 6 months -
comparative evaluation of lumbar plexus and suprainguinal fascia iliaca compartment blocks

Conditions: Orthopedic Disorder

Summary: the investigators aim to compare the use of a suprainguinal fascia iliaca compartment block vs lumbar plexus block as an adjunct to general anesthesia in pediatric patients undergoing orthopedic procedures involving the hip or upper femur. this study will help determine the efficacy of the two techniques and their advantages when compared to each other including time to perform the block, opioid consumption reduction, effects on postoperative pain, and the length of stay.


Eligibility criteria:
inclusion criteria: * asa grade i-iii * undergoing elective orthopedic surgical procedures involving the hip and upper thigh exclusion criteria: * local anesthetic allergy * skin or localized infection at the site of catheter insertion * patient or parent refusal
comparison of intralesional tranexamic acid and platelets rich plasma in the treatment of melasma

Conditions: Melasma

Summary: abstract objective: to study the efficacy while comparing intralesional tranexamic acid vs platelets rich plasma (prp) in treatment of melasma. study design: randomized-controlled trial (rct). study setting and duration: dept of dermatology, cmh-abbottabad, nov-2022 /april-2023. methodology: the sample size of 60 patients 20 to 40 years were calculated by using openepi app. the informed consent was taken. the patients were randomly allocated to two groups: group a (30 patients injected with intradermal tranexamic acid (4mg/ml) and group b (30 patients treated with prp (1ml) intra-dermally, every fourth week for up to 12 weeks between both groups). the mmasi scale was used to evaluate all patients. the final evaluation was performed on the 24th week of follow-up. for analysis statistical package for the social sciences version-27 was used. to determine statistical significance a paired t-samples test with a p-value of \< 0.05 was applied.


Eligibility criteria:
inclusion criteria: * 20_40 years of age * suffering from melasma exclusion criteria: * pregnancy * breastfeeding mothers * allergic to tranexamic acid * bleeding disorders * warts or facial eczema
assessment of pulpotomy procedure using neomta plus in permanent teeth with carious exposure

Conditions: Pulpotomy

Summary: many deep carious teeth are treated unnecessarily by root canal therapy, while with using current techniques and advances in compatible dental materials in addition to better understanding of biological response of the dental pulp, many can be treated conservatively via vital pulp therapy procedures.

vital pulp therapy is recommended for teeth diagnosed with reversible pulpitis or partially inflamed pulps in which the remaining healthy tissue can be conserved and protected by a biologically active material to generate a hard tissue barrier that seals and protects the pulp from future microbial insult. the aim of this in vivo study is to clinically and radiographically assess the outcome of full pulpotomy using a calcium silicate based material (neomta plus) in permanent teeth with carious exposure. ethics approval was obtained from the institutional ethics and research committee, and the patients were informed about details of the treatment and the possible complications. an informed consent was obtained. 120 patients meeting the inclusion criteria will be selected for this study and they will be subsequently followed up clinically and radiographically after 3 months, 6 months, 1 year and yearly afterward for 5 years.

Eligibility criteria:
inclusion criteria: * permanent teeth with mature or immature apices * have no significant medical problems * the tooth should give positive response to cold test and electric pulp test (ept) * probing pocket depth and mobility within normal limits * no signs of pulp necrosis including sinus tract or swelling * radiographically ; caries either exposing the pulps or reaching more than 2\\3 the distance from the dentino-enamel junction (dej) to the pulp * the tooth can be restored via direct restoration exclusion criteria: * medically compromised patients * negative response to cold test * mobility * sinus tract * swelling * non restorable teeth or badly broken teeth

Keywords: teeth pulpitis deep caries pulpotomy mineral trioxide aggregate (mta)
frequency and risk factors of acute myeloid leukemia

Conditions: Myeloid Leukemia

Summary: 1. to assess the frequency of acute myeloid leukemia at clinical haematology unit of assiute university hospital 2. to study correlations of known risk factors and if there are new risk factors participate in increasing frequency of acute myeloid leukemia

acute myeloid leukaemia (aml) is a rare heterogeneous disease comprising a group of hematopoietic neoplasms originating from the excessive clonal proliferation of myeloid pre- cursor cells \[1\]. diagnosis of aml is based on morphological diagnosis with proliferation of blast cells ≥ 20% of bone marrow cells, flow cytometric analysis and cytogenetic abnormalities, including the t(8;21)(q22;q22), t(15;17) (q22;q12) and inv (16)(p13.1;q22) which are associated with longer remission and survival, while alterations of chromosomes 5, 7, complex karyotype and 11q23 are associated with poor response to therapy and shorter overall survival \[2\] the etiological agent and pathogenesis of aml are not entirely clear, only few aml cases can be accurately classified through traditional cellular morphological classification \[3\]it is the most common acute leukaemia in adults. it accounts for 1.3% of new cancer patients in the united states, in 2018\[ 4\] some factors are well documented to increase the risk of some types of leukemia such as benzene exposure and ionizing radiation \[5\] increased frequency of acute myeloid leukemia has been noticed at haematology unit so the aim of the study to assess the the frequency of acute myeloid leukemia and to evaluate the risk factors for it .

Eligibility criteria:
inclusion criteria: * adult patients(above 18 years) diagnosed as acute myeloid leukemia according to who diagnostic criteria exclusion criteria: * patients with other types of leukemia
the effect of repetitive transcranial magnetic stimulation on cognitive impairment in parkinson's disease (pd)

Conditions: Parkinson's Disease With Cognitive Impairment

Summary: this study aims to assess the therapeutic role of rtms on parkinson's patients with cognitive impairment. patients diagnosed with parkinson's disease and cognitive impairment will be recruited. all patients will be admitted and will be allocated randomly into two groups one of which will receive real sessions of high frequency rtms for each hemisphere for 10 consecutive sessions totally over period of 10 days with repeated booster sessions every month during the period of follow up. the other will receive sham sessions.

this study aims to assess the therapeutic role of rtms on parkinson's patients with cognitive impairment. thirty pd patients with cognitive impairment using united kingdom (uk ) bank criteria for pd will be recruited from outpatient clinic in assiut university. all patients will be admitted at neuropsychiatric department, assiut university hospital/ assiut, egypt.each patient fulfilled the inclusion criteria as having score less than 24 on mini-mental status examination will be recruited. the patients will be allocated randomly into two groups one of which will receive real sessions of high frequency rtms (25 hz), with intensity of 80% of resting motor threshold detected from the hand motor area, with total 2000 pulses for each hemisphere for 10 consecutive sessions totally over period of 10 days with repeated booster session every month during the period of follow up among three months. the other will receive sham sessions. all subjects will be followed up by selected clinical rating scales at different intervals pre session, post 10 sessions, and after one, two and three months.

Eligibility criteria:
inclusion criteria: * all patients with parkinson's disease who were diagnosed according to uk bank criteria for pd, aged 45-75 years, with criteria for cognitive impairment (mini-mental status examination\< 24), and consent obtained from the patient or his caregiver. exclusion criteria: * history of repeated head injury * history of repeated cerebrovascular strokes * history of defined encephalitis * oculogyric crisis, supranuclear gaze palsy * family history of more than one relative * history of drug intake as antipsychotics or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) exposure * moderate and severe depression (hamilton depression rating scale score \>16) * severe dysautonomia * cerebellar signs * babinski sign * strictly unilateral features after 3 years * hydrocephalus or intracranial lesion on neuroimaging * we also excludes patients with intracranial metallic devices or with pacemakers or any other device.