Kornimate/medical-research-clean huggingface dataset:
radiomics of autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: autism spectrum disorder (asd) refers to a group of neurodevelopmental disorders including autism.despite ongoing studies, the pathogenesis of asd still remains unclear.the global prevalence of asd was estimated at 1% in 2015.the diagnostic criteria for asd are specified in the dsm ( american psychiatric association, 2013 ) and serve as guideline for clinicians at the present. however, its early diagnosis value is limited due to a high subjectivities and its low diagnostic sensitivity and specificity.early detection and early pharmacological and behavioral interventions are critical in improving the symptoms and preventing the disease progression. there are no medications that directly treat the core symptoms present in individuals with asd, and the effectiveness of interventions remains limited. therefore, accurate assessment of pharmacological efficacy is necessary for the reatment, and prognostication of individuals with asd. magnetic resonance imaging (mri) is a commonly used imaging tool for clinical disease diagnosis, especially for neurological disorders. besides, structural magnetic resonance imaging reflects neuropathological and microstructural developmental changes during growth. radiomics based on the high-dimensional quantitation of medical images, allowing extraction of more detailed characteristics than is possible with conventional visual interpretation. this study aims: (1)to explore an objective diagnostic method through radiomics in children with asd (2)to provide prognostic estimates of the outcome, based on estimates of an individual patient's prognosis and the efficacy of different drug therapies.


Eligibility criteria:
inclusion criteria:（a）healthy subject of same ages;(b)without injury to head and diseases of the nervous system; (c)without family history of mental disorders; (d)without other somatic illness. exclusion criteria: -

Keywords: mri radiomics
emri surescan™ clinical study

Conditions: Bradycardia; Slow Heart Beat

Summary: the purpose of this clinical study is to confirm safety and efficacy in the clinical magnetic resonance imaging (mri) environment of the investigational enrhythm mri™ surescan™ pacing system (used in support of revo mri™ surescan pacing system launch).

this study is a prospective, multi-center global study.

Eligibility criteria:
inclusion criteria: * subject has, or is at risk of having, a heart beat that is too slow and his/her doctor has determined he/she needs a pacemaker. * subject available for follow-up at study center for length of study. * subject able and willing to undergo elective mri scanning without sedation. exclusion criteria: * subject has, or is at risk of having, a heart beat that is too fast and his/her doctor has determined he/she needs an implantable cardioverter defibrillator (icd). * subject needs or will need another mri-scan, other than those required by the study, during the required study follow-up period. * pregnant women, or women of child bearing potential who are not on a reliable form of birth control. * subject with exclusion criteria required by local law. * subject who intends to participate in another clinical study during this clinical study.

Keywords: bradycardia slow heart beat magnetic resonance imaging (mri)
aftercare in the community health center

Conditions: Mental Disorders

Summary: this is a trial to examine the effects of aftercare for mental health patients in community health center (leistad). recruitment occurs among hospitalized patients in psychiatric hospitals (østmarka). after discharge, patients will be randomly assigned to one of two groups: intervention group (community health center, primary care) or control group (community mental health centers of district psychiatric service, specialist care). the project's primary objective is to investigate the effect of community services on patients' functional capacity and user satisfaction after discharge. secondly, the number of treatment days and readmissions to mental health care will be examined. the project will also compare costs of hospitalization, in psychiatric hospital and community health center respectively. data will be collected from community health records, medical records and patient systems in psychiatric hospital, community mental health centers of district psychiatric service (dps) and questionnaires filled out by patients.


Eligibility criteria:
inclusion criteria: * considered by the responsible manager to have given consent * hospitalized, diagnosed and treated such as can be continued in a district psychiatric service or a health center. * stable condition, but anxiety and disruptive behavior may occur to a lesser extent. * considered to have a perceived need for complex services from specialist health and community for a long time after discharge. exclusion criteria: * not in a stable phase thus shielding required

Keywords: community mental health centers norway aftercare
the effects of respiratory muscle strength training (rmst) on inspiratory and expiratory muscle strength in adults and children with pompe disease

Conditions: Pompe Disease

Summary: the purpose of the study is to determine if respiratory muscle strength training will be beneficial for inspiratory and expiratory muscle strength in adults and children with pompe disease.

respiratory muscle weakness results in substantial morbidity and mortality in individuals with almost all forms of neuromuscular disease (nmd), including both the infantile and adult phenotypes of pompe disease. although individual patterns of involvement vary, respiratory weakness in pompe disease typically affects both the inspiratory and expiratory muscle systems. our pilot data in two individuals with late-onset pompe disease suggest that rmst may be a treatment for the progressive respiratory weakness encountered in this condition. purpose of the study * determine the effect of respiratory muscle strength training on maximum inspiratory pressure, maximum expiratory pressure, upright % predicted forced vital capacity, and aspects of cough function. * determine the effect of rmst on functional outcome measures of gross motor function appropriate for individual participants in terms of age and motor skills.

Eligibility criteria:
inclusion criteria: * include skin fibroblast acid α-glucosidase (gaa) activity ≤1% of the normal mean, a minimum age of 3 years, the ability to participate in an intensive rmst research program, and the ability to maintain a consistent amount of nonresearch related physical activity over the course of the study. exclusion criteria: * include medical problems which preclude meaningful participation in the study, the inability to perform high effort respiratory tasks using maximum intensity, respiratory weakness so profound that rmst cannot be completed at the minimum pressure thresholds of available respiratory trainers, and the inability to safely perform the protocol. for example, high effort respiratory tasks are occasionally associated with mild, transient dizziness which quickly dissipates following a brief rest. if severe and/or prolonged dizziness were to occur in a particular case, then exclusion from the study would be necessary.

Keywords: pompe respiratory
a study that will compare the effect of two drugs on participants with low bone mass and a recent hip fracture

Conditions: Osteoporosis

Summary: this study will evaluate whether teriparatide is superior to the active comparator in the change from baseline of lumbar spine bmd (bone mineral density) in men and postmenopausal women with low bone mass and a recent pertrochanteric hip fracture.

the study has 3 periods: a screening phase, a double-blind, double-dummy treatment phase from the time of randomization to the 26 weeks visit, and an open-label treatment phase of approximately 12 month duration, where participants will continue treatment with the same study drug that they were randomized to.

Eligibility criteria:
inclusion criteria: * men and postmenopausal women aged ≥50 who have sustained a unilateral, fracture of the trochanteric region * lumbar spine bmd and/or femoral neck bmd and/or total hip bmd measurement of the contra lateral hip at least 2.0 sds (standard deviation) below the average bone mass for young women and men exclusion criteria: * clinically significant abnormal laboratory values * history of unresolved skeletal diseases that affect bone metabolism * polytrauma participants and participants with fractures at more than one site

Keywords: low bone mass recent pertrochanteric hip fracture
individually-guided hearing aid fitting

Conditions: Hearing Loss

Summary: this translational project aims to optimize the fitting of hearing aids by development and clinical validation of a toolset that guides signal processing choice based on the individual auditory and cognitive abilities of the patient.

the clinical trial portion of the project will validate clinical use of the toolset by evaluating a population of patients fit using current standard of care. patient characteristics, such as audiological profile and cognition, will be collected. their hearing aid settings will then be evaluated to determine if they meet toolset guidelines for signal processing based on their patient characteristics (auditory and cognition). data regarding subjective and objective hearing aid outcomes will also be collected. it is hypothesized that hearing aid fittings that meet the standards of the proposed clinical toolset will result in better patient outcomes (objective and subjective) and fewer post-fitting visits.

Eligibility criteria:
inclusion criteria: * sensorineural hearing loss with pure-tone thresholds 70 db hl or better at octave frequencies between 250 and 4000 hz, 4 (.5, 1, 2, 3 khz) * frequency pure-tone average (pta) of ≥ 30 db hl. * listeners will have symmetrical losses, defined here as a 4-frequency pta difference between ears ≤ 20 db hl. exclusion criteria: * recent (within last 12 months) hearing aid use * conductive loss (air-bone gaps \> 10 db at any frequency and/or abnormal immittance) - * scoring \< 23 on the montreal cognitive assessment * hearing loss exceeding the limits that can be successfully aided with hearing aids (i.e., profound hearing loss) * hearing loss remediated with a cochlear implant (cannot wear hearing aids) * significant history of otologic or neurologic disorders * non english speaking participants * any clinically significant unstable or progressive medical condition * any condition which, in the opinion of the investigator, places the participant at unacceptable risk if he or she were to participate in the study.
safety and tolerability study of v501 in japanese boys (v501-200)

Conditions: Anogenital Human Papilloma Virus Infection; Condyloma Acuminata

Summary: this is a study of v501 \[quadrivalent human papillomavirus (hpv) (type 6, 11, 16 and 18) l1 virus-like particle (vlp) vaccine\] in healthy japanese boys. this study will consist of two periods. period i of the study is to evaluate the immunogenicity and tolerability of v501 up to month 7. period ii of the study is to evaluate the long-term immunogenicity and safety from month 7 to month 30. two analyses are planned. the first analysis will be conducted when all subjects have completed their month 7 visit or have been discontinued before that time. the second analysis will be conducted at the end of study. the primary hypothesis tested in this study is that seroconversion rates for the vaccine hpv types will be \>90% at 4 weeks postdose 3.


Eligibility criteria:
inclusion criteria: * healthy japanese male * have a legal representative who provides written informed consent for the trial on the participant's behalf * have a legal representative who is able to read, understand, and complete the vaccine report card * has not yet had coitarche and does not plan on becoming sexually active from day 1 through month 7 of the study * other inclusion criteria will be discussed with the investigator during screening exclusion criteria: * currently enrolled in clinical studies of investigational agents * history of known prior vaccination with an hpv vaccine or plans to receive one outside the study * history of severe allergic reaction that required medical intervention * allergic to any vaccine component, including aluminum, yeast, or benzonase™ * received immune globulin or blood-derived products in the past 6 months or plans to receive any before month 7 of the study * history of splenectomy, is currently immunocompromised, or has been diagnosed with immunodeficiency, human immunodeficiency virus (hiv) infection, lymphoma, leukemia, systemic lupus erythematosus, rheumatoid arthritis, juvenile rheumatoid arthritis, inflammatory bowel disease, or other autoimmune condition * received immunosuppressive therapy in the past year, excluding inhaled, nasal, or topical corticosteroids * known thrombocytopenia or coagulation disorder that would contraindicate intramuscular injections * ongoing alcohol or drug abuse within the past 12 months * history of genital warts or a positive test for hpv
bfa treatment of pain

Conditions: Musculoskeletal Pain; Acute Pain

Summary: the aim of this pilot study is to conduct an unblinded pilot randomized clinical study on the effectiveness and tolerability of auricular semi-permanent (asp) vs intradermal (long), and pyonex needles in battlefield acupuncture (bfa) for the treatment of pain.

1. begin to identify which of 3 needles is most efficacious for bfa treatment of pain; 2. identify patient experiences and tolerance of three commonly used acupuncture needles at mike o'callaghan military medical center at nellis air force base. this study will compare 30 patients (10 per needling group) and will serve as a pilot study for a potential larger randomized control trial (rct) across multiple mtfs in the defense health agency (dha) to establish better bfa care practices. we will be recruiting a total of 39 subjects, which is inclusive of a 30% drop out rate to accommodate those that may be lost to the study or have missing data to achieve a final total of 30 subjects.

Eligibility criteria:
\*\*patients must be able to get care at nellis air force base (a military installation) in order to participate in this study\*\* inclusion criteria: * active duty and dod beneficiaries aged 18 years or older * acute (0-4 days) musculoskeletal injury * injuries eligible for inclusion include all acute non-fracture related musculoskeletal injuries of the axial or peripheral skeleton. exclusion criteria: * taking any opioid medications daily * rheumatologic and autoimmune conditions which may be creating pain, such as rheumatoid arthritis, advanced osteoarthritis, or spinal stenosis * contra-indication to needle use including known bleeding disorder and psychogenic issues related to needle use (e.g., needle-phobia) * evidence or history of clinically significant immune deficiency, hematological, oncological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or severe allergic disease (including to metals and adhesive tapes) which could interfere with this study * individuals with progressive radiating pain with motor-sensory changes (including weakness or numbness) related to their presenting pain complaint * women who are pregnant, may be pregnant, or attempting to become pregnant

Keywords: acupuncture battlefield acupuncture
myosfascial trigger-points and effects on neuromuscular response

Conditions: Myofascial Trigger Point Pain

Summary: the aim of this study is to analyze the effects of the treatment of the myosfascial trigger-points detected in the gastrocnemius muscles on the neuromuscular response.


Eligibility criteria:
inclusion criteria: * subjets with both active or latent myosfascial trigger points exclusion criteria: * pregnant women * musculoskeletal problems in the last month * surgical interventions in he knee, hip, ankle, back or neck in tha last 6 months * psychological or nervous alterations * uncomprehension of the study protocol
excia t cementless ebra study

Conditions: Arthritis, Degenerative; Arthritis, Rheumatoid; Hip Fractures; Femur Head Necrosis

Summary: in this post market clinical follow-up study (pmcf study), the short-term clinical and radiological results of the cementless excia t® prosthesis in routine clinical use shall be assessed and the migration taking place in the first 24 months evaluated.


Eligibility criteria:
inclusion criteria: * written patient consent to study participation * age \> 18 years * indication for primary tha with cementless excia t® stem exclusion criteria: * pregnancy * tha after fracture * rheumatoid arthritis * systemic disorders, treated with cortisone or other pharmaceuticals, potentially compromising the bone quality * patient physically or mentally not able to follow the postoperative examination routine

Keywords: total hip arthroplasty
group-based cognitive-behavioral therapy for adults with attention-deficit/hyperactivity disorder inattentive-type

Conditions: Attention Deficit Disorder With Hyperactivity

Summary: the newly developed cbt for adhd inattentive-type (adhd-i) protocol is tested for feasibility and acceptability in a pilot study with a single group design. the study also evaluates measurements and recruiting possibilities, and effects of the intervention. research hypotheses include: 1. there is a basis for recruiting adhd-i patients for participation in an rct at psychiatric outpatient units, 2. the measurements in the study are feasible and reasonable in regards to patient characteristics; that is, the patients are responding to the questionnaires as intended, 3. the cbt for adhd-i intervention is feasible in terms of treatment completion, compliance to home assignments, and credibility and relevance, and is lacking of or involves a tolerable degree of adverse effects, and 4. the cbt for adhd-i protocol reduces core symptoms of adhd-i as well as symptoms of stress, depression, and anxiety, and improves quality of life.


Eligibility criteria:
inclusion criteria: in addition to an adhd inattentive-type diagnosis, inclusion criteria are: 1. 18 years or older, 2. intelligence quotient above 80-85, and 3. if on medication, it needs to be well-established since three months. exclusion criteria: 1. autism spectrum disorder, 2. ongoing substance use disorder, 3. difficulties in compliance with medical or other treatment, 4. social and/or psychiatric problems to such an extent that it prevents focusing on treatment, or 5. ongoing cognitive-behavioral therapy.
spine angle comparison in adult seating posture with immediate feedback

Conditions: Spinal Curvatures; Feedback, Psychological; Sitting Position

Summary: 1. background: in modern society, people are spending more time sitting due to the increased use of it devices. prolonged sitting with incorrect posture can lead to spinal deformities and an increase in spinal diseases. common deformities include turtle neck posture, flat back, straight neck, and bent back. misalignment of the spine is considered an important factor in causing spinal diseases, such as pain, arthritis, and degeneration. to address these issues, researchers have developed pillows and chairs that are ergonomically designed for everyday use and have been found to be effective. 2. purpose: this study aims to investigate whether portable equipment can help individuals recognize and maintain correct sitting posture on their own. 3. design: this study has a cross-sectional study design. each condition is divided into three different sitting conditions. by using post-evaluation data, the intention is to compare the effects. (condition a: sitting on a standard chair wearing an immediately feedback device, condition b: sitting on a gym-ball, condition c: sitting on standard chair) 4. subject : twenty-eight subjects were recruited as healthy students attending s university located in nowon-gu, seoul. 5. result: the study found that maintaining a sitting posture immediately resulted in a statistically significant lower angle over time at the cervicothoracic angle compared to other interventions. similarly, a sitting posture immediately maintained a lower angle over time at the thoracic angle compared to other sitting postures . however, the lumbar angle showed a significant increase over time.


Eligibility criteria:
inclusion criteria: * healthy 20-year-olds with no visual and hearing problems and no problems with video viewing and agreeing to participate in the experiment exclusion criteria: * those who needed treatment due to pain in the neck, chest, or back were excluded. those who had been diagnosed with a diagnosis that stopped studying and stopped sports activities in the past 12 months were excluded.
safety and tolerability study of apn01 (recombinant human angiotensin converting enzyme 2)

Conditions: Pulmonary Diseases; Cardiovascular Diseases; Kidney Diseases; Cancer Diseases

Summary: the purpose of this study is to define the dose for a phase ii study and to investigate safety and tolerability of intravenous administration of recombinant soluble human angiotensin converting enzyme 2 in healthy volunteers.

apn01-1-01 is a placebo controlled double blinded phase i study composed of a single dose, dose escalation part followed by a multiple dosage part. the first four cohorts (four individuals each) will receive 100, 200, 400 and 800 µg/kg apn01 i.v. or placebo. cohorts 5 and 6 (three individuals each) will receive three and six i.v. apn01 administrations daily, respectively. planned dosage of the multiple dose part will be 400 µg/kg.

Eligibility criteria:
inclusion criteria: * male or female * age ≥18 years * use of acceptable form of birth control * willing to comply with study protocol * no significant background illness * signed informed consent form exclusion criteria: * significant hematological, renal, hepatic, metabolic, psychiatric or pulmonary diseases. * heart disease or elevated blood pressure. * any other significant disease that could interfere with the subject's ability to complete the protocol * history of alcohol or drug abuse * abnormal urinalysis * pregnant or lactating female subjects * use of anticoagulants or antihypertensive drugs, particularly drugs interfering with the renin-angiotensin-aldosterone system, obesity or anorexia (bmi \ 30) * history of malignancy, except basal cell carcinoma of the skin, known history of human immunodeficiency virus (hiv), hepatitis b or hepatitis c infection or positive serology testing in the study screening procedures (except indicating immunization) * participation in a clinical trial within the last 30 days * any of the following laboratory abnormalities: * wbc 15% outside of normal limits * hemoglobin 15% outside of normal limits * platelets 15% outside of normal limits * aspartate transferase (ast) or alanine transferase (alt) above 15% outside of normal limits * alkaline phosphatase above 15% outside of normal limits * urea above 15% outside of normal limits * creatinine above 15% outside of normal limits.

Keywords: ras ace2 cardiovascular pulmonary angiotensin ii angiotensin 1-7