Kornimate/medical-research-clean huggingface dataset:
acupuncture for qol and symptoms in gastric cancer during adjuvant chemotherapy

Conditions: Stomach Neoplasms

Summary: in the investigator's pilot study(nct 03753399), a trend of improvement of quality of life, as well as release of symptoms, in gastric patients in acupuncture groups was indicated. this study will evaluate the efficacy of acupuncture on qol in gastric cancer patients undergoing postoperative adjuvant chemotherapy with more samples. enrolled participates will randomly receive high-dose acupuncture, low-dose acupuncture or non-acupuncture during the first 3 cycles of adjuvant chemotherapy after resection.


Eligibility criteria:
inclusion criteria: * 1.pathologically diagnosed with gastric cancer or esophagogastric junction cancer after r0 resection and d2 lymph node dissection; * 2.pathological stage ii or stage iii * 3.without tumor recurrence confirmed by image examination; * 4.no chemotherapy after surgery, planning to accept at least 3 cycles of adjuvant chemotherapy; * 5.age:18\~75 years old * 6.ecog score≤ 2 * 7. normal organ function, including: 7.1 bone marrow function: absolute neutrophil count (anc)≥1.5×10e9/l, platelet (plt)≥100×10e9/ l,hemoglobin (hb)≥90g/l; 7.2 kidney function: serum creatinine (scr)≤1.5mg/dl(133μmol/l), or creatinine clearance rate (ccr)≥60ml/min; 7.3 liver function: total bilirubin (tb)≤1.5×upper limit of normal value (uln), alanine transaminase (alt)≤2.5×uln, aspartate transaminase (ast)≤2.5×uln; * 8. can understand the study well and finish the questionnaires in this study; 9. with the written informed consent. exclusion criteria: * 1. can not finish the baseline assessment; * 2. needle phobia; * 3. currently diagnosed with psychiatric disorder (e.g., severe depression, obsessive-compulsive disorder, or schizophrenia); * 4. history of autoimmune diseases, hematological diseases or organ transplantation, or long term use of hormones or immunosuppressors; * 5. implanted with heart pacemaker; * 6. has accepted neoadjuvant radiotherapy before surgery; * 7. planning to accept adjuvant radiotherapy after surgery; * 8. with active infection; * 9. acupuncture treatment within the previous 6 weeks; * 10.pregnant or lactating women.

Keywords: gastric cancer acupuncture quality of life symptom burden adjuvant chemotherapy
a study to evaluate the safety and efficacy of ombitasvir/paritaprevir/ritonavir and dasabuvir with ribavirin in adults with genotype 1 and ombitasvir/paritaprevir/ritonavir with ribavirin in adults with genotype 4 chronic hepatitis c virus infection and decompensated cirrhosis

Conditions: Chronic Hepatitis C; Decompensated Cirrhosis; Hepatitis C Virus

Summary: the primary objectives of this study are to assess the safety and the svr12 rate of ombitasvir/paritaprevir/ritonavir and dasabuvir with rbv in gt1-infected participants with decompensated cirrhosis.


Eligibility criteria:
inclusion criteria: 1. hcv gt1- or gt4-infection defined as: positive for anti-hcv ab, hcv rna \> 1,000 iu/ml and laboratory result indicating hcv gt1 or gt4 infection at screening. 2. evidence of cirrhosis by prior liver biopsy, fibroscan or by radiograph (i.e., computed tomography \[ct\] scan or magnetic resonance imaging \[mri\]). 3. child-pugh score of 7 - 9, inclusive, at time of screening. exclusion criteria: 1. women who are pregnant or breastfeeding. 2. positive test result for hepatitis b surface antigen (hbsag) or anti-hiv antibodies (hiv ab). 3. prior or current use of any other investigational or commercially available anti-hcv agents other than interferon/rbv and/or pegylated interferon (pegifn)/rbv (including but not limited to telaprevir, boceprevir, sofosbuvir and simeprevir). 4. confirmed presence of hepatocellular carcinoma indicated on imaging techniques such as ct scan or mri within 3 months prior to screening or on an ultrasound performed at screening (a positive ultrasound result will be confirmed with ct scan or mri). 5. any current or past evidence of child-pugh c classification.

Keywords: cirrhosis hepatitis c child-pugh b hepatitis c genotype 4 interferon-free hepatitis c genotype 1 chronic hepatitis c decompensated cirrhosis hepatitis c virus
community based participatory research with immigrant chinese with diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: the proposed project is part of a program of research to improve management of type 2 diabetes (t2dm) through a community-academic partnership that addresses cultural factors in disease management. specific aims are to: 1. strengthen a community-academic partnership with the immigrant chinese community in san francisco to improve diabetes management; 2. adapt and test a behavioral diabetes intervention, coping skills training, to addresses family and cultural issues in immigrant chinese patients with t2dm; and 3. disseminate the adapted coping skills training program findings via the community-academic partnership to the immigrant chinese american community through service programs, ethnic media, and professional/scientific publications. a mixed-methods cbpr approach will be used to interpretively adapt a behavioral intervention to be culturally appropriate, and test its efficacy using a repeated measures design. two historically significant social service and health agencies serving immigrant chinese in san francisco are collaborating with this nurse-led interdisciplinary research team.

the goal of the culturally adapted chinese coping skills training (ccst) is to increase immigrant chinese patients' skills and mastery in diabetes management by identifying and diminishing non-constructive coping responses to difficult social situations, while expanding the repertoire of positive coping responses and disease management behaviors. the ccst comprises a series of six small-group sessions focused on the topics of social problem solving, communication skills, cognitive behavior modification and conflict resolution. it also includes a review of basic diabetes management information.

Eligibility criteria:
inclusion criteria: * diagnosed with type 2 diabetes mellitus, * treated with insulin, oral medications and/or diet and exercise, * self-identify as chinese american or chinese, * identify a family member (spouse, child, sibling or other person identified as family) with whom participant lives or has at least weekly contact, who is involved in care of diabetes. * first-generation immigrant ie. foreign-born, first generation to arrive in the u.s. from any source country exclusion criteria: * diagnosed with type 1 diabetes mellitus * cannot read or write chinese

Keywords: coping skills chinese immigrant type 2 diabetes mellitus family research
the relationship between prolonged hospitalization and surgical experience in pediatric tonsillectomy cases.

Conditions: Sleep Apnea; Tonsillitis Recurrent

Summary: guided by the expertise of a seasoned surgeon at the tertiary care hospital, the training program includes performing tonsillectomy starting from the 6th month. the clinical protocol at the hospital dictates a standard one-night hospital stay for all patients, but there is potential to extend the duration in specific cases. the study endeavors to explore the correlation between extended hospitalization, surgical proficiency, patient-specific factors, and postoperative complications in pediatric patients who underwent tonsillectomy and/or adenotonsillectomy at the clinic.


Eligibility criteria:
inclusion criteria: * patients under 18 years of age having tonsillectomy surgery * patients whose records are available in the hospital archive exclusion criteria: * inadequate information in files

Keywords: tonsillectomy prolonged hospitalization
effect of teriflunomide treatment on microglial activation in an ms patient cohort at risk of progression

Conditions: Multiple Sclerosis

Summary: to evaluate the effect of teriflunomide treatment on microglial activation in late stage multiple sclerosis.

in multiple sclerosis (ms), plaques in the white and grey matter of the brain represent the best known pathological changes of the disease, but a significant inflammation process has also been detected outside these plaques in connection with the disease. this extensive, diffuse inflammatory process correlates with the progression of the disease, measured by edss score (expanded disability status scale status) and reduction in patients' cognitive level. according to neuropathological research, the diffuse inflammatory process outside the plaques is connected with powerful activation of microglia, oxidative stress, and deficiencies in mitochondrial activity. the activation of microglial cells can be measured in vivo in patients using positron-emission tomography (pet) scanning and so-called tspo radioligands, such as the 11c-pk11195 radioligand. 11c-pk11195 radioligand binds to tspo molecules, which manifest on the surface of activated, but not un-activated, microglia. teriflunomide treatment is expected to slow down the process of increasing microglial activation. tspo-pet imaging allows in vivo follow-up of the pathogenic process associated with the gradual ms disease evolution, and allows to evaluate whether teriflunomide treatment has an effect on disease progression-related pathology.

Eligibility criteria:
inclusion criteria: * signing the consent form * having used teriflunomide treatment for at least 6 months * 40-55 years of age at the time of signing the research consent form * ms diagnosis in accordance with either the poser or mcdonald criteria * edss 2-6.5 * clear lesion load in brain mri (\> 9 t2 lesion) exclusion criteria: * patients suffering from another brain disease of in addition to multiple sclerosis * steroid treatment 4 weeks prior to the scan * significant pathology in the mri scan other than ms-related lesions * patients suffering from claustrophobia or panic disorder, or patients who have exhibited hypersensitivity of pet markers (practical obstacle to the scan) * exposure to experimental radioactivity in the last 12 months such that the dosimetry threshold would be exceeded due to participation in the study * severe hepatic impairment * pregnant women, or women of childbearing potential who are not using reliable contraception during treatment with teriflunomide and thereafter as long as its plasma levels are above 0.02 mg/l.
a multicentre study to explore the efficacy and safety of mucopolysaccharide polysulfate cream in patients with eczema

Conditions: Eczema

Summary: the study was designed to collect information over 1800 patients with a clinical diagnosis of subacute or chronic eczema, these patients' prescriptions contain hirudoid®. easi, iga and more indicators are evaluated. data were collected for a maximum of 12 weeks according to the clinician's consultation and follow-up (time points were set at baseline, 1, 2, 3, 4, 8 and 12 weekends). the above data were analysed to explore the optimal treatment modality, dose and treatment period for patients with subacute or chronic eczema.

the study was designed to collect information over 1800 patients with a clinical diagnosis of subacute or chronic eczema, these patients' prescriptions contain hirudoid® (hirudoid® alone or in combination with glucocorticoids). basic demographic information (age, sex, height, weight, lifestyle, occupation), vital signs (blood pressure, heart rate, temperature, etc.), past medical and treatment history, eczema area and severity index (easi) scores and corresponding symptom scores, dermatology life quality index (dlqi) score, investigator's global assessment (iga) of disease severity score, visual analogue scale (vas) with subject's pruritus, photographs of the eczema area and recurrence rate were collected. data were evaluated for a maximum of 12 weeks according to the clinician's consultation and follow-up (time points were set at baseline, 1, 2, 3, 4, 8 and 12 weekends). the above data were analysed to explore the optimal treatment modality, dose and treatment period for patients with subacute or chronic eczema.

Eligibility criteria:
inclusion criteria: 1. 18-75 years of age, male or female;. 2. patients with a clinical diagnosis of subacute or chronic eczema and whose prescription contains hirudoid®. 3. subjects fully understand the content of this study, sign informed consent. exclusion criteria: 1. hypersensitivity to any of the ingredients of this product. 2. patients with heparin hypersensitivity, bleeding-prone constitution and known heparin-induced thrombocytopenia. 3. open wounds and broken skin and mucous membranes 4. patients with localized combined bacterial, viral and fungal infections. 5. pregnant or lactating women or those who are unable to use contraception during the study period 6. those with psychiatric disorders, poor compliance and unable to complete the study. 7. any other reason that the investigator considers inappropriate for inclusion.
the effect of high dose vitamin c in burn patients

Conditions: Burns

Summary: the purpose of this study is to see if intravenous vitamin c will decrease the amount of iv fluids needed following burn injury in the first 48 hours.

adequate fluid resuscitation in burn injured patients to allow adequate renal blood flow has been the hallmark of burn care in the last 50 years. the danger of exceeding the optimal intravenous fluid resuscitation has resulted in severe complications including abdominal compartment syndrome, loss of upper airway control, extremity compartment syndromes and pulmonary edema. hig dose vitamin c infusion during the first 24 hours of burn resuscitation has been documented to decrease the overall amount of intravenous fluid needed to provide for adequate renal perfusion and hemodynamic stability in multiple animal model studies. high dose vitamin c is thought to decrease postburn microvascular protein and fluid leakage by reducing postburn lipid oxygenation caused by burn injury generated free radicals.

Eligibility criteria:
inclusion criteria: * \>/= 20% total body surface area full and partial thickness burns * admitted to the usaisr burn center within 10 hours post injury exclusion criteria: * pregnant or breast feeding * documented preadmission or admission renal failure * history of glucose-6-phosphate dehydrogenase deficiency, kidney stoves, gout or sickle cell * electrical injury * renal replacement of any kind\<24 hours after admission

Keywords: burns
music therapy in pulmonary rehabilitation

Conditions: Chronic Pulmonary Disease

Summary: this study explores the effects of music therapy intervention on anxiety and time perception during pulmonary rehabilitation.

background： in recent years, in many domestic and foreign music therapy literature, it can be found that the intervention of music therapy can alleviate the anxiety of patients in the treatment, surgery, and even patients with critical care using ventilators, and then affect the patient's physiological indicators, in addition, there are also studies that mention that background music affects people's waiting time perception, reduces people's waiting time, can reduce the generation of negative emotions, and improve the quality of hospital medical care. the objective of this study was to explore the effects of music therapy on anxiety and time perception during pulmonary rehabilitation. study design： this case is a one-year single-center, prospective block randomizied trial. methods： the study is expected to be 50 people, randomly assigned to two groups (control group, experimental group) will be carried out in the pulmonary rehabilitation room on the sixth floor of the fu jen catholic university hospital, using the baker anxiety scale, physiological monitoring instruments and cardiac output monitor as tools to test the effects of anxiety sensations, physiological responses (heartbeat, breathing times, blood pressure, heart rate variability) and perceptual time in two situations of interventional music therapy and non-interventional music therapy during the rehabilitation of negative pressure respirators. effect： it was mainly found that the intervention of music therapy can reduce anxiety, number of heartbeats, number of breaths and blood pressure, and shorten the perceptual time of patients with pulmonary rehabilitation. key words： music therapy; pulmonary rehabilitation; depression; percieved time; chronic obstructive pulmonary disease

Eligibility criteria:
inclusion criteria: * recieved pulmonary rehabilitation at least three months * recieved a negative ventilation during a pulmonary rehabilitation * a written informed consent exclusion criteria: * impaired of hearing * decline to participate * cognitive communication deficits * acute exacerbation of copd within three months

Keywords: music therapy pulmonary rehabilitation depression percieved time chronic obstructive pulmonary disease
the ameliorative effects of glp-1ra on diabetic cardiac autonomatic neuropathy

Conditions: Type 2 Diabetes; Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)

Summary: diabetic cardiac autonomic neuropathy (dcan) is a common chronic complication that reduces survival in patients with diabetes. epidemiological surveys have shown that the prevalence of dcan is 25-75% in people with type 2 diabetes. the onset of dcan is insidious and easy to be ignored in the early stage. with the progression of the disease, the following clinical symptoms gradually appear, including reduced heart rate variability, exercise intolerance, resting tachycardia, orthostatic hypotension, painless myocardial infarction and even sudden death, which seriously endanger the life and health of type 2 diabetes patients. existing literature has shown that glucagon-like peptide-1 receptor agonist (glp-1ra) can improve diabetic peripheral neuropathy and diabetic cognitive dysfunction, but there are few studies on improving diabetic autonomic neuropathy. insulin resistance is an important risk factor for dcan. patients with type 2 diabetes are characterized by insulin resistance, and glp-1ra is recognized as a drug to improve insulin resistance and control blood sugar in patients with diabetes. in this study, glp-1ra was used to intervene patients with type 2 diabetes, and the changes in blood sugar control and insulin resistance status of patients were followed up. special attention was paid to the improvement of autonomic neuropathy in diabetic patients.


Eligibility criteria:
inclusion criteria: 1. patients aged 18-70 years 2. patients with t2dm who meet the diagnostic guidelines 3. the patient signed the relevant informed consent form 4. being overweight or obese exclusion criteria: 1. \<18 years old 2. pregnant or lactating women 3. acute and chronic pancreatitis 4. recent acute complications of diabetes 5. arrhythmia or taking drugs that affect heart rate 6. thyroid disease 7. severe organ dysfunction 8. denial of informed consen

Keywords: t2dm，dcan，hrv, cart，insulin resistance
couples motivational interviewing to reduce drug use and hiv risk in vulnerable male couples

Conditions: Substance Use; HIV Infections

Summary: this study utilizes a randomized controlled trial design to evaluate the efficacy of couples motivational interviewing (mi) to reduce the frequency and severity of illicit drug use and frequency of hiv transmission risk behavior (trb). participants are randomized to one of two conditions: couples mi or standard couples hiv testing and counseling (chtc).


Eligibility criteria:
inclusion criteria: * have a main partner who is another cisgender male and have been in a relationship for 3 month or longer * index participant must be between 18 and 55; main partner can be any age 18 and older * one participant must be hiv negative (as confirmed by rapid test) * one participant must have used at least 1 drug in the past 30 days (cocaine/crack, opiates, misuse of prescription medication, stimulants, psychedelics, ecstasy, ketamine, ghb, amyl nitrite) * index participant must have engaged in trb in the past 30 days- defined as cas with a casual partner, or a serodiscordant or non-monogamous main partner * live in the united states * speak and read english exclusion criteria * any signs of serious mental illness or cognitive deficit * current suicidal/homicidal ideations * history of ipv with their main partner and safety concerns in the current relationship.
evaluation of serological markers of vitiligo activity

Conditions: Vitiligo

Summary: the goal of this case-control study is to evaluate the possible applicability of cxcl10, cxcl9, ccl20, and homocysteine as biomarkers of disease activity in vitiligo patients and to compare the levels of these markers with those in healthy controls.

the diagnosis and prognosis assessment in patients with vitiligo are essentially clinical. there are still no validated and established serological markers to objectively assist in defining disease activity. objective: to evaluate the potential use of the biomarkers cxcl9, cxcl10, ccl20, s100b, and homocysteine to identify disease activity in vitiligo, comparing their values with controls. methods: a case-control study using previously collected peripheral blood samples from patients aged 18 years or older with a diagnosis of vitiligo and from controls without the disease. the project was approved by the institution's ethics committee. tests were conducted using elisa and luminex kits to measure cxcl9, cxcl10, ccl20, and s100b. for homocysteine, the chemiluminescence method was used.

Eligibility criteria:
inclusion criteria: * vitiligo * older than 18 years exclusion criteria: * not having diagnosis of vitiligo * less than 18 years

Keywords: biomarker vitiligo
mindfulness meditation format pilot study

Conditions: Posttraumatic Stress Disorder; Depression

Summary: the purpose of this study is to assess feasibility of an internet and individual format of mindfulness meditation in people with posttraumatic stress disorder (ptsd) and depression symptoms

internet and individual formats of mindfulness meditation have not been previously evaluated. in order establish feasibility of such formats a pilot study is need. the current study will randomize up to 20 people with ptsd and depression symptoms and evaluate changes in ptsd and depression symptoms from before to after the internet and individual mindfulness meditation interventions.

Eligibility criteria:
inclusion criteria: * good general health * age 25-65 * access to internet * ptsd symptoms (score \>14 on ptsd screen) * depression symptoms (endorsement of one question on depression screen) * stable on medications six weeks prior to the study * willing to be stable on medications during study exclusion criteria: * significant potentially life-limiting acute medical illness * risk for suicide * \>2 drinks/day of alcohol and street drug use besides marijuana * current daily meditation practice