Kornimate/medical-research-clean huggingface dataset:
inulin in burn-induced insulin resistance

Conditions: Burn Injury; Insulin Resistance; Post Burn Insulin Resistance

Summary: in this clinical trial, investigators will test the effects of dietary supplement inulin, on the reduction of insulin resistance developed as a result of burn injuryy.

as a consequence of burn injury, an exaggerated inflammatory response is developing in parallel with metabolic changes, which led to the development of hyperglycemia and insulin resistance. the post burn-injury insulin resistance is different in comparison to other trauma-induced insulin resistance. the main difference is the length. more precisely postburn-injury insulin resistance lasts longer than insulin resistance developed after other traumas. insulin resistance can persist for years after the burn heals. inulin is a heterogeneous mixture of fructose polymers that are widely distributed in nature as storage of carbohydrates in plants. this mixture of fructose has nutritional value, but also affects general health, reducing the risk of developing various diseases. inulin prevents gastrointestinal complications such as constipation, increases the resorption of minerals from the gastrointestinal tract, stimulates the immune system, and functions as a prebiotic, but can also affect insulin resistance in patients with metabolic syndrome. the hypothesis: the everyday inulin can affect postburn-injury insulin resistance. to investigate the effect of inulin on patients with postburn-injury insulin resistance a prospective, double-blind, randomized, and placebo-controlled clinical trial will be performed. this initial trial is a pilot trial. the pilot trial will be performed to assess the safety of treatment or interventions and recruitment potentials, examine the randomization and blinding process, increase the researchers' experience with the study methods and interventions, and provide estimates for sample size calculation for the main study.

Eligibility criteria:
inclusion criteria: * informed consent and willingness in study participation * the age of the respondent greater than or equal to 18 years at the time of signing the informed consent * burns requiring in-hospital treatment * insulin resistance detected on the fifth day of admission to the hospital exclusion criteria: * documented pre-existing insulin resistance * pcos * bmi ≥ 30 kg/m2 * pregnancy * diabetes type 1 * diabetes type 2 * metabolic syndrome * use of drugs that can affect insulin resistance * weight loss greater than 10% in the last 6 months
effect of probiotics on periodontitis stage iii grade c molar-incisor pattern

Conditions: Periodontal Diseases

Summary: the research highlight the effectiveness of probiotics as adjuncts to srp in the treatment of periodontitis stage iii grade c molar-incisor pattern

background data : periodontitis is a common disease that represents a public health problem. aggregatibacter actinomycetemcomitans (a. a ) especially the jp2 genotype plays a major role in the pathogenesis of periodontitis. the aim of this study is to evaluate the effect of topically applied probiotics on the management of periodontitis stage iii grade c molar-incisor pattern. methods: sixty-five patients having periodontitis stage iii grade c molar-incisor pattern. screening for a. actinomycetemcomians (a.a) and the jp2 genotype was done using conventional polymerase chain reaction (pcr). patients positive for (a. a) were randomly divided into two groups. group i: received conventional periodontal treatment combined with topically applied probiotic, while group ii: received conventional periodontal treatment only. both groups were evaluated microbiologically and clinically. quantitative assessment of a. a levels was done by real time pcr (qpcr) at baseline as well as one week, 4 weeks, and 12 weeks after treatment. clinical parameters were assessed before treatment as well as 3,6 and 9 months after treatment.

Eligibility criteria:
inclusion criteria: * patients have periodontitis stage iii grade c molar-incisor pattern . exclusion criteria: * pregnant or nursing women, * smokers, * patients received periodontal therapy, * systemic antimicrobials or anti-inflammatory drugs in the last six * patients with unacceptable oral hygiene

Keywords: periodontitis agg. actinomycetemcomitans jp2 genotype pcr local delivery drug probiotics
satisfaction with nurse administered propofol sedation vs. midazolam with fentanyl sedation for endoscopy

Conditions: Inflammatory Bowel Disease; Endoscopy; Sedation

Summary: sedation for endoscopy is a service more than a necessity. therefore it should be patient driven. patients with inflammatory bowel disease (ibd) undergoes life long endoscopic control. therefore, satisfaction with the procedure experience is paramount for patients with ibd. investigators wish to study the feasibility and the effect on patient experience of two drugs. propofol administered by endoscopy nurses (naps) and conventional therapy with a combination of fentanyl and midazolam. investigators hypothesize that patients sedated with propofol has a better procedure experience, that a well performed sedation equals a better experience and that naps is as feasible as fentanyl with midazolam sedation.


Eligibility criteria:
inclusion criteria: * inflammatory bowel disease (ibd) or suspected ibd * planned endoscopy * candidate for propofol sedation * willingness to be randomized * ability to complete questionnaire exclusion criteria: * allergy to drugs * american society of anesthesiologists class iii * body mass index \> 35 * ventricular retention * acute condition * severe chronic obstructive pulmonary disease * sleep apnea * potentially difficult airway or previous difficulty with anesthesia * pregnancy * \<18 years

Keywords: inflammatory bowel disease ibd sedation naps propofol midazolam satisfaction feasibility
treating albp with acupuncture - comparison of the efficacy between distal points and local points

Conditions: Low Back Pain

Summary: this study is a randomized controlled trial on acupuncture for acute low back pain(albp). according to literature, using distal acupoints only to treat albp is mostly recognized, but in our daily clinical practice, it is common to use local acupoints mainly combined with distal acupoints. which method leads to better effect is one important clinical question in treating low back pain(lbp) by acupuncture. in this proposed study, the investigators aim to compare the efficacy of using "distal acupoints only" and "local acupoints mainly combined with distal acupoints" on albp.

it will be a randomized controlled trial on acupuncture for albp, conducted at the pok oi hospital - hong kong baptist university chinese medicine clinic cum training and research centre (kowloon city district) (kcdcmctr). registered chinese medicine practitioner(rcmp) with at least two years of clinical experience and trained to treat participants in accordance with study protocols. 102 (18-65 years in age) participants with albp will be recruited from the public through advertisement and from the clinic (kcdcmctr). eligible participants will be randomly assigned to two groups. the participants are randomly allocated into two groups: distal acupoints only group(dpog) and local acupoints mainly combined with distal acupoints group(lpmg). the dpog (n=51) will receive acupuncture of distal acupoints only(si3, ex-ue7). the lpmg (n=51) will receive acupuncture of local acupoints mainly(bl23, bl25, bl32) combined with distal points(bl40). participants will be treated twice a week for a total of four weeks. every participant will be administered 8 sessions of acupuncture. the primary outcome will be the change in low back pain intensity(in vas scores) before and after the treatment. the secondary outcomes will be the oswestry disability index. all outcomes will be evaluated at every session of treatment and the follow up period. follow-up will be scheduled 1 month and 3 months after the completion of treatments. this clinical trial lasts 4 months.

Eligibility criteria:
inclusion criteria: * low back pain as chief complaint: pain and discomfort, localized below the costal margin and above the inferior gluteal folds, with or without leg pain; * participants' aged between 18 and 65 years old; * acute onset of symptom: lasting less than 6 weeks; * provided informed consent prior to the study. exclusion criteria: * low back pain lasting more than 6 weeks; * alerting features (red flags) or serious conditions associated with acute low back pain: significant trauma, unexplained weight loss, past history of malignancy, fever, age \>65 years old, severe and unremitting night-time pain; * contraindication of acupuncture, including needle phobia, severe cutaneous condition, excessive hunger/exhaustion/overeat, emotional instability, pregnancy(relative contraindication) etc.; * received acupuncture treatment during the last month.

Keywords: acute
predictors of disease recurrence after curative surgery for stage i colon cancer

Conditions: Colon Cancer Stage I; Colon Cancer

Summary: patients with stage i (pt1-2 n0 m0) colon cancer (cc) accounts for 15-20% of colonic neoplasia. stage i cc is mostly cured with surgical resection, consequently, adjuvant chemotherapy is never considered for this subset of patients. moreover, some international guidelines, including nccn guidelines, recommend less intensive follow-up 1. however, around 5% of patients with stage i cc will develop a recurrence within 5 years from surgery. despite the very good prognosis usually attributed to this stage (5-years relapse-free survival: 95%), some clinical and pathological factors beyond the standard ajcc staging may be associated with worse clinical features and may aid in prognostic stratification. although some authors investigated the role of pathological and clinical factors in patients with stage ii and iii disease, only few data are available for patients with stage i cc1. the present multicentric retrospective study aims to: 1. assess the actual incidence of recurrence in a large cohort of patients with stage i cc undergone curative resection. 2. investigate the clinical and pathological characteristics of patients who developed a recurrence, with the aim of identifying those associated with a significantly increased risk. 3. analyze the pattern of recurrence. 4. analyze survival after recurrence.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * colon cancer up to recto-sigmoid junction * histological diagnosis of adenocarcinoma * pt1 or pt2 according to ajcc staging system * urgent and elective surgery * curative resection * minimally invasive or open surgery * completion surgery included (surgery for endoscopically resected pt1) exclusion criteria: * rectal cancer * adenoma with low- or high-grade dysplasia * histology other than adenocarcinoma (i.e., lymphoma, neuroendocrine tumor, squamous carcinoma, etc) * neo-adjuvant chemotherapy or radiotherapy * history of tumors other than cc

Keywords: prognosis recurrence
the sweet kids study (stevia on weight and energy effect over time)

Conditions: Weight Gain; Adiposity; Insulin Sensitivity; Microbial Colonization

Summary: this is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old. the main purpose of the study is to evaluate if stevia (as with other sweeteners and consistent with prior research in children and adults) has benefits for weight control and metabolic function relative to caloric sweeteners, and whether it provides benefits in this regard similar to water.

the proposed study will be an 8 to14-week three-arm randomized controlled blinded trial in children ages 8 to12 years from the central, arkansas region. children with normal weight (bmi percentile \<85th, n = 90) and excessive weight (bmi percentile ≥85th and \<140% of the 95th, n =120) will consume either: 1. sucrose-sweetened beverage 2. stevia-sweetened beverage 3. calorie free flavored water beverage participants with excessive weight will complete a 14-week intervention to assess both primary and secondary hypotheses. in parallel, normal weight participants will be enrolled with the objective of monitoring indicators of safety for steviol consumption through assessment of changes in metabolic function (glucoregulation and cardiometabolic) markers as well as assessment of shifts in gut microbial communities and steviol metabolism over 8 weeks

Eligibility criteria:
inclusion criteria: * age 8-12 years * normal weight: bmi percentile ≥5th to \<85th * excessive weight: bmi percentile ≥ 85th and \<140% of the 95th percentile or bmi ≥35 to \<40 kg/m2 * current consumption of sugar sweetened beverages (≥3 times /wk) * low consumption of non-nutritive sweeteners (≤ 3 time/wk) * willingness to consume experimental products exclusion criteria: * children with class 3 obesity (i.e., bmi ≥ 140% of the 95th percentile or bmi ≥ 40.0 kg/m2) * dislike of experimental beverage taste (assessed at initial screening) * severe persistent asthma (determined by daily use of inhaler(s) to keep asthma symptoms under control). * exercise induced asthma. * autism spectrum disorder (e.g., autistic disorder, rett disorder, asperger disorder, childhood disintegrative disorder, pervasive developmental disorder not otherwise specified (pdd-nos). * attention deficit hyperactivity disorder (adhd). * oppositional defiant disorder (odd). * epilepsy. * chronic kidney disease. * hormonal disease (e.g., hypothyroidism and growth hormone deficiency). * autoimmune diseases (e.g., lupus, thyroiditis, juvenile idiopathic arthritis) * bleeding disorders (e.g., hemophilia) * chronic infections (e.g., hiv, hepatitis b, hepatitis c). * mental health disorders (e.g., depression and anxiety). * type 2 and type 1 diabetes mellitus. * other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest. * parent/child refusal to have blood drawn. * fasting glucose ≥126 mg/dl at enrollment. * fasting a1c ≥6.5% at enrollment or follow up visits. * less than 2 months since completion of antibiotics

Keywords: cardiometabolic health
laparoscopic versus open right hemicolectomy within eras in right-sided colon cancer

Conditions: Colon Cancer

Summary: in this study, the investigators have compared the clinical outcomes of the laparoscopic and open right hemicolectomy within enhanced recovery after surgery (eras) programs in the treatment of right-sided colon cancer.

this study was a prospective, single-center, randomized control trial. including criteria were (1) age between 18 and 75 years; (2) histologically confirmed right-sided colon adenocarcinoma；(3) clinical stage i-iii; (4) performance status (ecog) 0-1; (5) adequate hematological, hepatic and renal function. patients operated on as an emergency, or with tumours in the transverse colon, or with other previous malignancy within 5 years were excluded. all particapants were recruited and randomly assigned to receive laproscopic or open right hemicoloectomy. all patients were treated with an eras protocol. the primary end-point was the incidence of postoperative complications within 30 days. complications were diagnosed and classified according to the clavien-dindo classification. the secondary end-points were eras adherence, readmissions, reoperations, hospital length of stay, mortality, and survivals. the study was approved by the ethics committee of zhongshan hospital, fudan university, shanghai, china. written informed consent was obtained for patients to participate the study. this study followed the consolidated standards of reporting trials (consort) reporting guideline.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 and ≤ 75 years; 2. primary tumor has undergone histologically confirmed right-sided colon adenocarcinoma; 3. together with clinical or radiological evidence of stage(t1-2,n0, m0) stage ii (t3-4, n0, m0) or stage iii (t1-4, n1-2, m0) disease (according to the 2007 revision of the international union against cancer tnm staging system) 4. performance status (ecog) 0\~1 5. adequate hematological function: neutrophils≥1.5 x109/l and platelet count≥100 x109/l; hb ≥9g/dl (within 1 week prior to randomization) 6. adequate hepatic and renal function: serum bilirubin≤1.5 x upper limit of normal (uln), alkaline phosphatase ≤5x uln, and serum transaminase (either ast or alt) ≤ 5 x uln(within 1 week prior to randomization); 7. written informed consent for participation in the trial. exclusion criteria: 1. other previous malignancy within 5 years, with exception of a history of a previous basal cell carcinoma of the skin or pre-invasive carcinoma of the cervix 2. pregnancy (absence confirmed by serum/urine β-hcg) or breast-feeding 3. known drug abuse/ alcohol abuse 4. legal incapacity or limited legal capacity 5. pre-existing peripheral neuropathy.

Keywords: enhanced recovery after surgery right hemicolectomy
trazodone on nrem sleep stage ⅲ in depressed insomniac co-morbid patients

Conditions: Depressed Insomniac Co-morbid Patients

Summary: this study used polysomnographic technology and randomly selected 60 patients who met the diagnostic criteria for depression and non-organic insomnia as stipulated in dsm-5 into an intervention group (n=30) and a control group (n=30). the intervention group was given only 5-hydroxytryptamine balanced antidepressants trazodone, while the control group was given citalopram hydrobromide combined with zolpidem. both groups underwent psg at baseline and 1 week after medication, and were assessed with the 17-item hamilton depression rating scale, zung self-rating depression scale, pittsburgh sleep quality index, arnsworth insomnia severity scale, antidepressant side effects checklist, and the drug dependence scale neuropsychological assessment at baseline, 1, 2, and 4 weeks after medication. the study aimed to explore the effects of single use of smas class antidepressants versus combination with other antidepressants on non-rapid eye movement sleep stage iii in patients with depression and insomnia comorbidity, and to compare the effects of depression and insomnia in the two groups.


Eligibility criteria:
inclusion criteria: * outpatient or inpatient patients; * 18 years old ≤ 65 years old; * simultaneously meet the diagnostic criteria for depression and non organic insomnia in the fifth edition of the diagnostic and statistical manual of mental disorders (dsm-5) in the united states; * 17 items of hamilton depression rating scale (hamd-17) with a total score of ≥ 17 points; * pittsburgh sleep quality index (psqi) ≥ 16 points; * never used related antidepressants and sedative hypnotic drugs; * has a certain level of visual and auditory resolution, and no comprehension barriers; * capable of independently completing scale measurements; * education level above primary school; * obtain written informed consent from the patient, and obtain written informed consent from the legal guardian if the patient is incapacitated during the onset of the illness. exclusion criteria: * patients with comorbidities such as schizophrenia, schizophrenia, bipolar disorder, mental retardation, pervasive developmental disorder, delirium, dementia, cognitive impairment, alcohol dependence, etc * suffering from serious organic diseases, such as diabetes, thyroid disease, hypertension, cardiovascular disease, craniocerebral trauma, cerebral ischemia or hemorrhage; * patients with narrow angle glaucoma; * history of epilepsy and febrile seizures; * individuals with a history of drug use; * positive for syphilis specific antibody and aids antibody; * according to risk assessment, there are currently serious suicide attempts or individuals who are overly agitated pregnant or lactating women, or those planning to conceive in the near future; * laboratory tests indicate the presence of liver and kidney function impairment in individuals; * there are other individuals who meet the relevant contraindications for antidepressants.

Keywords: trazodone non-rapid eye movement sleep stage depression insomnia
erector spinae plane block in liver transplantation donors

Conditions: Pain, Postoperative

Summary: living donor liver transplantation has become a common treatment option for patients with end-stage liver disease. donor hepatectomy is associated with significant postoperative pain due to inverted l-shaped incision. therefore adequate analgesia is important for recovery. erector spinae plane block (espb) is a safe anesthesia technique used to provide postoperative analgesia. this study aimed to compare the novel ultrasound-guided espb technique with controls in terms of postoperative opioid consumption and postoperative pain control on donor patients.


Eligibility criteria:
inclusion criteria: * donor patients scheduled for elective hepatectomy in liver transplantation surgery * asa i-ii * patients who are aged between 18-65 exclusion criteria: * patients who do not accept the procedure * skin infection at the site of erector spina plan block area * coagulation disorder or using anticoagulant drugs * known local anesthetics and opioid allergy * severe pulmonary and/or cardiovascular problems * substance addiction or known psychiatric or mental problems * chronic painkiller usage * pregnancy or lactation
caring for children in vital distress

Conditions: Emergencies; Children

Summary: errors during a stressful pediatric critical situation occur more frequently than thought. the main aim of the study is to quantify the number and the type of errors made by pediatric paramedical teams during the management of vital emergencies (medication dosage calculation, compliance with algorithms for management of cardiac arrest...). then, simulations with and without the easypédia software will be compared during a high-fidelity simulation of a standardized pediatric cardiac arrest scenario in order to evaluate its impact on reducing errors during the management of a resuscitation. this study will be a single-center and observational trial in the pediatric intensive care unit of the besançon university hospital.

the study is divided in two parts : part 1 : non-interventional study part with children in vital distress enrollment. fifteen patients will be recruited over a period of 1 year in the intensive care unit. part 2 : high-fidelity simulation tests part at a simulation platform with assessment of the easypedia software. sixty health care givers divided in 2 groups, experts (intensive care units and specialist mobile emergency units) and non experts (pediatric medicine and pediatric emergencies units) in vital distress care, will be included over a period of 4 months. they will be submitted to two simulation scenarios : with and without the easypedia software. the first part follows a case-only observational study model and the second part follows a case-crossover one. concerning the time perspective, the first part is a cross-sectional study and the second part is prospective.

Eligibility criteria:
part 1 in intensive care unit : inclusion criteria: * patients in vital distress taken in charge in intensive care unit : transported by the specialist mobile emergency units, transferred from an other unit of the besancon university hospital or from a peripheral hospital on medical decision * children from 0 to 15 years exclusion criteria: * premature newborns and patients transported by the specialist mobile emergency units or transferred from an other unit of the besancon university hospital on medical decision not presenting a vital emergency following evaluation of the medical team of the intensive care unit * subject being in the period of exclusion from another study or provided by the national volunteer file part 2 in simulation : inclusion criteria - expert teams of doctor and paramedics (10 from pediatric intensive care unit and specialist mobile emergency units) and non expert teams of doctor and paramedics (10 from pediatric medicine and pediatric emergencies units) exclusion criteria * non-consenting doctor or paramedic * doctor or paramedic who has worked at night for less than 48 hours * care givers under guardianship ou curatorship