Kornimate/medical-research-clean huggingface dataset:
experience with a pediatric summer intensive therapy program

Conditions: Neurodevelopmental Disorders

Summary: the purpose of this study is to explore the lived experiences of children with neurodevelopmental diagnoses and their caregivers with an intensive model of therapy. children will receive usual care during the summer intensive program and the investigators will access medical records to assess effectiveness. children and caregivers will also be asked to participate in semi-structured interviews upon the completion of the episode of care.

the purpose of this study is to explore the lived experiences of children with neurodevelopmental diagnoses and their caregivers with an intensive model of therapy. research questions include: 1.) what are the perceptions of children and caregivers about intensive therapy after participating in multiple intensive therapy episodes over time? 2.) why do caregivers choose to continue with an intensive model of therapy periodically for their child with neurodevelopmental diagnoses? 3.) what were the outcomes for children with neurodevelopmental disabilities participating in an episode of intensive therapy? children will receive usual care during the summer intensive program and the investigators will access medical records to assess effectiveness. children and caregivers will also be asked to participate in semi-structured interviews upon the completion of the episode of care.

Eligibility criteria:
inclusion criteria: * children receiving therapy through the children's therapy center's tiger intensive program and their caregivers from may 24 to august 13 2021. exclusion criteria: * n/a

Keywords: pediatric rehabilitation intensive therapy
effects of pursed-lip breathing on exercise tolerance and dynamic hyperinflation in copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: pursed-lip breathing (plb) has been advocated to reduce respiratory rate and improve oxygen saturation in patients with chronic obstructive pulmonary disease (copd) at rest. although plb is a strategy that potentially reduces expiratory flow limitation, there are only few studies addressing its effects on exercise. this study aimed to assess the ability of plb to change the breathing pattern, degree of dynamic hyperinflation (dh) and arterial oxygenation in copd patients during exercise. exercise tolerance was evaluated by endurance time and respiratory mechanics was evaluated by forced oscillation technique.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic obstructive pulmonary disease (copd) * regular treatment at clementino fraga filho university hospital (ufrj) exclusion criteria: * exacerbation in the preceding 4 weeks * spo2\<85% at peak exercise * other diseases that may contribute to dyspnea and exercise intolerance

Keywords: exercise tolerance dynamic hyperinflation respiratory mechanics
a study of the efficacy and safety of tocilizumab for confirmed rheumatoid arthritis (ra) participants in clinical practice

Conditions: Rheumatoid Arthritis

Summary: this is a single-arm, open-label, non-randomized, multicenter trial to evaluate the efficacy and safety of using tocilizumab for confirmed rheumatoid arthritis participants in clinical practice.


Eligibility criteria:
inclusion criteria: * diagnosed with moderate-to-severe active rheumatoid arthritis (ra) for over 3 months * started on tocilizumab, with or without previous history of biological treatment exclusion criteria: * pregnant or lactating women * treated with an investigational drug within 30 days prior to initiation of study drug * having a condition that, in the opinion of the investigator, could compromise the participant's safety or interfere with the study results
clinical characteristics of patients referred to a substance abuse liaison department in an academic hospital, france

Conditions: Substance Abuse; Emergencies; Personality Disorders; Substance Use Disorders

Summary: the coalition on psychiatric emergencies (cpe) stressed in 2016 that emergency providers were increasingly recognizing the important role of the emergency department (ed) in reducing adverse outcomes associated with untreated with substance abuse liaison department (suds). additional research is required to close identified knowledge gaps and improve care of ed patients with sud. of the more than 4.5 million ed visits in 2009 in us for drug-related causes,34-32% involved alcohol use alone or in combination with other drugs. few studies investigated the clinical characteristics of patients referred to an addiction liaison department in a general hospital. the present study will be retrospective in a sample of 700 patients consecutively admitted for addictive behaviors in the emergency department and in the medicine or surgery departments of the amiens university hospital center, france.


Eligibility criteria:
inclusion criteria: * patient addressed to university hospital emergency department and consecutively referred to a substance abuse liaison department in the amiens academic hospital, france between 2017 and 2020. * patients must be able to speak french exclusion criteria: * neurological disorders * patients who are not able to speak french

Keywords: substance abuse liaison-department emergencies academic hospital personality disorders substance use disorders
mastoid bone autograft for dorsal nasal augmentation

Conditions: Nose Deformities, Acquired

Summary: the purpose of this study is to evaluate the safety and efficacy of mastoid bone autograft for dorsal nasal augmentation in rhinoplasty.

introduction: several grafts and/or implants have been used for dorsal augmentation. in some cases, especially the traumatic, non-caucasian, and multi-operated ones, the amount of augmentation is higher than the usually available from septal and auricular conchal autografts. objective: to evaluate the safety and efficacy of mastoid bone autograft for dorsal nasal augmentation in rhinoplasty. design: a prospective study of 15 consecutive patients submitted to dorsal nasal augmentation with mastoid bone, during a 2-year period. setting: one major academic medical center.

Eligibility criteria:
inclusion criteria: * nasal acquired or congenital deformity of the dorsum that requires augmentation of more than 5 mm exclusion criteria: * previous otologic surgery/disease

Keywords: nasal acquired diseases nasal congenital diseases rhinoplasty grafts
diagnosis of hiv and early antiretroviral therapy initiation among hiv-1 infected infants

Conditions: HIV Infections; Hiv

Summary: the purpose of the study is to test the effect of the alere™ q hiv-1/2 detect (diagnostic assay) on uptake of hiv testing among hiv-exposed infants and young children, and health outcomes for hiv-infected infants and young children using a novel poc eid community model in zambia. the study will also assess the feasibility of field implementation of this novel diagnostic tool and its acceptability among hiv-infected mothers and frontline health workers.

the purpose of the study is to test the effect of the alere™ q hiv-1/2 detect (diagnostic assay) on uptake of hiv testing among hiv-exposed infants and young children, and health outcomes for hiv-infected infants and young children through a novel poc eid community model in zambia. the study will also assess the feasibility of field implementation of this novel diagnostic tool and its acceptability among hiv-infected mothers and frontline health workers. the knowledge generated from this study will enable the zambia ministry of health (moh) to make informed policy decisions about the implementation and scale up of point of care (poc) diagnostic tools for early infant diagnosis and pediatric hiv treatment programs in zambia and the region.

Eligibility criteria:
inclusion criteria include iycs: 1. 0 days (at birth) - 17 months of age; 2. probable or known hiv exposure documented through maternal sero-positivity or reactive infant hiv antibody test; 3. the iyc must be born to mothers who: 1. attended ≥1 anc visits without hiv testing; or 2. delivered at home and did not return for post-natal care at a health facility, and thus the mother or their child were not tested for hiv; or 3. were documented as hiv-infected but never initiated art; or 4. disengaged from hiv care after art initiation/have not returned for arv refills; or 5. have not returned to the facility with their infant for initial eid testing or follow-up eid testing (after a negative test at birth or 6 weeks); or 6. iyc not tested 6 weeks after cessation of breastfeeding. 4. with a parent/guardian ≥18 years of age, and willing and able to provide written informed consent in a study language (english, nyanja, or bemba). exclusion criteria include iycs: 1. with documented age-appropriate, guideline-adherent receipt of dbs-based eid hiv pcr testing; 2. already known to be hiv-infected / receiving art.

Keywords: eid hiv early infant diagnosis point of care infant hiv
sonographic analysis of nails in psoriatic arthritis and healthy controls

Conditions: Psoriatic Arthritis; Psoriatic Nail

Summary: this study aims to identify the nail ultrasonography (nusg) properties in patients with psoriatic arthritis (psa) and healthy controls by a participant-based evaluation; to assess feasibility, reliability, and discriminative performances; to explore final scorings; and to determine associations between the nusg scores and participant characteristics, including demographics and disease-related factors.

nusg is a visualization method suitable for evaluating the subunits of the nail. the main purpose of this study is to identify nusg properties in patients with psa and healthy controls. the investigators recruited patients with psa according to the caspar criteria and sex- and age-matched healthy controls into the study. nusg parameters were examined by grayscale and power doppler techniques for all of the fingernails and first toenails (12 nails); and five scorings including nail plate impairment score (npis), nail plate thickness score (npts), nail bed thickness score (nbts), nail thickness score (nts), and the doppler activity score (das) were calculated. the investigators compared the psa and control groups in terms of the nusg scorings and also documented the discriminative performances (with receiver operating characteristic curve analysis) of the scorings. then, the feasibility and reliability analysis of the nusg scorings were performed. finally, the association between the nusg scores and participant characteristics, including sex, age, body weight, height, labor market participation, smoking, hemoglobin, disease duration, history of dactylitis, current enthesitis, radiographic sacroiliitis, c reactive protein, minimal disease activity, disease activity index for psoriatic arthritis, nail psoriasis severity index, and psoriasis area severity index were explored.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of psoriatic arthritis * healthy controls without any musculoskeletal disease * must be at the age of 18-70 years exclusion criteria: * infection of the nails to be examined * loss of nails to be examined * trauma history of the nails to be examined * having the habit of nail-biting * peripheral neuropathy * peripheral vascular disease * any rheumatological disease, except psoriatic arthritis * systemic infection * pregnancy

Keywords: nail ultrasonography psoriatic arthritis
comparison of three different treatment regimes in early rheumatoid arthritis: a randomized open-labelled trial

Conditions: Rheumatoid Arthritis

Summary: many studies have been conducted to evaluate the role of pulse steroids in early rheumatoid arthritis (ra) but no consensus exists. the aim of this study is to study the efficacy of various treatment regimens in early ra. methods: this is a randomized open-labeled trial. patients were randomised into three groups. in group a, patients were treated with single drug (methotrexate 15 mg/wk). the patients in group b were treated with a combination of dmards (methotrexate, sulfasalazine and hydroxychloroquine). the patients in group c received combination therapy as in group b and 3 pulses of methylprednisolone intravenously.

many studies have been conducted to evaluate the role of pulse steroids in early rheumatoid arthritis (ra) but no consensus exists. the aim of this study is to study the efficacy of various treatment regimens in early ra. patients were divided into three groups. in group a, patients were treated with single drug (methotrexate 15 mg/wk). the patients in group b were treated with a combination of dmards (methotrexate, sulfasalazine and hydroxychloroquine). the patients in group c received combination therapy as in group b and 3 pulses of methylprednisolone intravenously.

Eligibility criteria:
inclusion criteria: 1. rheumatoid arthritis diagnosed on the basis of revised american college of rheumatology criteria,1987 2. age \>18 years 3. early rheumatoid arthritis i.e. less than 2 years duration 4. patient giving consent to participate in study 5. disease modifying anti-rheumatic drugs naive - exclusion criteria: 1. pregnant and lactating patient or planning to conceive in next year 2. patient who had joint surgery in last 6 months 3. co morbidities such as liver disease, kidney disease, hematological malignancies 4. uncontrolled hypertension, diabetes mellitus 5. coronary artery disease -

Keywords: rheumatoid arthritis steroid
the role of atrial natriuretic peptide in the lipolytic process: effect of obesity and exercise

Conditions: Obesity

Summary: in the developing countries, obesity prevalence is on a dramatic rise. obesity is related to co-morbidities and as a result, obesity significantly shortens life expectancy and lowers quality of life. to prevent this, participation in exercise or training programs is absolutely necessary, in order to generate adipose tissue mass loss. the amount of adipose tissue mass loss is, amongst others, dependent on lipolysis which is under endocrine regulation by, mainly, catecholamines, insulin and atrial natriuretic peptide. however, large variations in adipose tissue mass loss and gain are likely in obese subjects, possibly due to a decreased lipolytic effect of these hormones (as was shown for catecholamines in the subcutaneous adipose tissue of obese subjects). however, the relative contribution of atrial natriuretic peptide in the lipolytic process remains elusive, particularly in subjects with obesity, which show an increased plasma expression of atrial natriuretic peptide. the aim of the present study is to observe the contribution of atrial natriuretic peptide in the subcutaneous adipose tissue of obese subjects. this will be tested by measurements of extracellular glycerol levels (by microdialysis) in the subcutaneous adipose tissue in situ at rest and during endurance exercise under local beta- and alpha-blockade. eventually, the knowledge gained from this research will contribute to the optimization of exercise programs for people with obesity.


Eligibility criteria:
inclusion criteria: * obese group: bmi \> 30 kg/m², sedentary (no regular physical activity last 6 months), insulin sensitive or insulin resistant * lean controls: bmi \> 18.5 kg/m² and \< 25 kg/m², regular physical activity, insulin sensitive exclusion criteria: * regular glucose lowering medication or beta blockade medication * presence of chronical diseases * orthopedic or neurological problems

Keywords: obesity adipose tissue lipolysis lipolysis microdialysis atrial natriuretic peptide
effectiveness of crd-4730 in participants with catecholaminergic polymorphic ventricular tachycardia (cpvt)

Conditions: CPVT1; Heart Defects, Congenital; Heart Diseases; Ventricular Tachycardia

Summary: this is a phase 2, multicenter, double-blind, sponsor unblinded, placebo-controlled, single-dose clinical study of crd-4730 to evaluate the safety, tolerability, pharmacokinetics (pk), and pharmacodynamics (pd) of crd-4730 when administered as single oral doses to participants with catecholaminergic polymorphic ventricular tachycardia (cpvt). the study will have 2 cohorts in which participants with cpvt will participate in a 3-period, randomized 2-sequence study. each participant will receive 2 different doses of crd-4730 and 1 dose of matching placebo, with each study drug administered as a single dose.


Eligibility criteria:
inclusion criteria: 1. males or females ≥18 years of age, at screening. 2. confirmed cpvt diagnosis, based on genetic screening for a known ryr2 mutation and a clinical phenotype consistent with cpvt at screening. 3. the participant can perform an est during which frequent premature ventricular contraction (pvcs) (≥10 per minute), ventricular bigeminy, or higher-grade va (equivalent to a va score ≥2) are identified by the investigator. 4. stable doses of any anti-arrhythmic medication, except amiodarone, for 4 weeks prior to screening. 5. adhere to all contraceptive criteria. exclusion criteria: 1. clinically significant structural heart disease, diagnosis of heart failure, or clinically significant coronary artery disease. 2. history of a myocardial infarction, cerebrovascular accident, or transient ischemic attack within 3 months of screening. 3. history of malignancy within the past 5 years at screening (except successfully treated basal cell carcinoma or non-metastatic squamous cell carcinoma of the skin or cervical carcinoma in situ). 4. female participant that is pregnant or lactating/ breastfeeding, or has plans to do so during the study or within 3 months following last dose of study drug. 5. use of amiodarone with 3 months prior to screening. note: other protocol defined inclusion/ exclusion criteria may apply.

Keywords: camkii catecholaminergic polymorphic vt ventricular tachycardia crd-4730
open-label long-term extension study of fesoterodine in japanese subjects with neurogenic detrusor overactivity.

Conditions: Urinary Bladder, Neurogenic

Summary: the purpose of this study is to investigate the safety and tolerability of fesoterodine following once daily long-term treatment in japanese pediatric neurogenic detrusor overactivity (ndo) subjects.

this is a phase 3, multi-center, open-label long-term extension study in japanese ndo subjects who participated and completed in the precedent study a0221047 which is a 24 weeks, randomized, open label study, to investigate the safety and tolerability of fesoterodine. this study consists of a 28-week open-label treatment period followed by a 4-week follow-up. in addition, subjects in the oxybutynin arm of the precedent study a0221047 will continue the fesoterodine treatment until week 40 visit in this study, in order to obtain fesoterodine 1 year treatment data.

Eligibility criteria:
inclusion criteria: •subjects who completed 24 week treatment and all visit procedures in the precedent study a0221047 exclusion criteria: * subjects who had major protocol violation (as determined by the sponsor) in study a0221047 * concomitant medications which may increase the risk to subjects or confound study results * other medical conditions which may increase the risk to subjects or confound study results

Keywords: neurogenic detrusor overactivity fesoterodine japan
recasting or book reading by parents or clinicians

Conditions: Developmental Language Disorder and Language Impairment

Summary: developmental language disorder (dld) affects approximately seven percent of the population and is characterized by grammatical deficits that cascade into lifelong academic challenges and under-employment. current treatments for dld produce good outcomes under ideal, high intensity conditions or when parents have been trained to deliver therapy using intense coaching methods; however, current publicly funded service delivery systems and private-pay reimbursement models do not support treatment being delivered in this ideal fashion for children older than three. this project will examine alternative methods of delivering treatment that may be more feasible under typical conditions and will identify implementation barriers, with the goal of improving long-term outcomes for children with dld. we hypothesize that feasibility and palatability will influence dose, which will in turn affect the overall language outcomes.


Eligibility criteria:
inclusion criteria: child with dld * age: 4-9 years old * primarily english speaking: as documented by 20% or less exposure to another language, per parent report on the maple * diagnosed with dld as documented by standard score below 85 on the diagnostic evaluation of language variation - norm referenced (delv-nr) composite, a dialect neutral assessment (seymour, roeper, de villiers, \& de villiers, 2005). * nonverbal intelligence quotient (iq) within typical range as documented by a t-score at or above 35 on the developmental abilities scale (das), matrices similarities subscale, (elliott, 2007). * hearing within the typical range: pass screening at 25 db for 1, 2, 4 khz; or scores within the typical range via soundscouts hearing screening app; or clear hearing assessment from an audiologist, otolaryngologist, medical doctor, or other professional. * no diagnosis of autism: cutoff score of 15 on the social communication questionnaire, (rutter, bailey, \& lord, 2003) * no diagnosis of significant sensory-motor concerns or significant psychiatric disorders per parent report * able to benefit from treatment: * score below 60% correct on experimenter developed elicited production probes of passives and object relative clauses * producing simple transitive sentences (svo) and mean length of utterance (mlu) of 2.5 on 100 utterance language sample caregiver * serves as the primary caregiver for an eligible child (may include grandparents, etc.) * basic literacy skills per self-report * willing to participate in caregiver training and caregiver-based treatments if child is assigned to that condition * willing to participate in questionnaires and structured interviews during post-test

Keywords: recasting book reading parent coaching syntax stories theoretical domains framework complex syntax expressive language language intervention
cardiovascular disease risk factors and healthy lifestyle behaviours in patients with ankylosing spondylitis

Conditions: Ankylosing Spondylitis (AS)

Summary: a review of the literature did not identify any studies that assessed knowledge of cardiovascular disease risk factors and healthy lifestyle behaviours in patients with ankylosing spondylitis. the aim of this study is to assess knowledge of cardiovascular disease risk factors, healthy lifestyle behaviours and physical activity levels in patients with ankylosing spondylitis.


Eligibility criteria:
inclusion criteria: * diagnosis of ankylosing spondylitis according to asas diagnostic criteria * being aged 18-65 * stable medication use for at least 3 months * voluntary participation in the study exclusion criteria: * having uncontrolled cardiopulmonary disease * being pregnant * having undergone recent surgery * presence of malignancy