Kornimate/medical-research-clean huggingface dataset:
strategic intervention on preserving language function during awake craniotomy

Conditions: Glioma

Summary: this study is designed to compare the language function after traditional or a new surgical plan during awake craniotomy for glioma resection.

this study concentrates on patient who has type ii language area glioma occupation. the investigators designed new surgical plan which is using monopolar stimulator to determine and retain the tumor margin within 5 mm from the posterior superior longitudinal fasciculus or posterior arcuate fasciculus. for the tradiitional surgical plan, the investigators use bipolar stimulator according to the current standard surgery plan. after they positive points are identified by stimulator, the positive points are retained to preserve the motor function while all the negative points of the tumor are resected. this study is to determine whether the new surgical plan is more suitable for type ii language area glioma occupation.

Eligibility criteria:
inclusion criteria: 1, patients with glioma near or on the language function area that have the necessity to undergo awake craniotomy and language function identification during tumor resection exclusion criteria: 1. patients with incompleted monitoring procedures; 2. paitents without data of the pre-and postoperative resting state mri, diffuison tensor image and functional mri.

Keywords: functional preservation awake craniotomy language impairment
lung perfusion pet / ct using ga68-maa for preservation of lung function during stereotactic pulmonary radiation therapy

Conditions: SBRT; Non-small Cell Lung Cancer; Lung Metastasis

Summary: this is a prospective study evaluating the feasibility of treatment planning integrating lung perfusion pet/ct using ga68-maa to preserve functional lung areas during stereotactic body radiation therapy (sbrt).

lung perfusion pet / ct is a new imaging modality based on the use of the same cold molecules as those used for a conventional perfusion lung scan. similartly, perfusion images are obtained after intravenous administration of human albumin macroaggregates, which are embolized in pulmonary capillaries according to pulmonary blood flow. however, these cold molecules are radiolabeled, not with technetium99m, but with gallium68, a ß + isotope, allowing image acquisition with pet technology. the same physiological processes are therefore observed with conventional scintigraphy pet imaging, but pet is an intrinsically superior technique for image acquisition, with greater sensitivity, better spatial and temporal resolutions and the possibility to perform respiratory-gated acquisition, allowing a better definition of the pulmonary functional volumes. the aim is to evaluate the feasability of functional lung avoidance planification using lung perfusion pet/ct imaging during sbrt. patients will benefit from a pre-treatment functional assessment including pet/ct imaging. the treatment planning will be carried out in 2 stages: * first, an anatomical planning will be carried out, blinded to the pet results. * then, a functional planning, respecting the standard constraints applied during anatomical planning, but also incorporating a new "functional lung volume" constraint defined by pet/ct images, will be carried out. a follow-up will be carried out for 12 months, including repeated perfusion pet/ct imaging at 3 and 12 months.

Eligibility criteria:
inclusion criteria: * age \>18 years * insured patient * patient treated at the brest chru for sbrt of a primary or secondary pulmonary lesion exclusion criteria: * unable/unwilling to give informed consent * pregnancy / breast-feeding patient * patient under guardianship or curatorship * patient with contraindication to the administration of macroaggregates of human albumin

Keywords: perfusion imaging positron emissiontomography lung cancer sbrt radiation induced lung injury
plasma angiopoietin levels in children following cardiopulmonary bypass

Conditions: Congenital Heart Defects

Summary: during cardiopulmonary bypass (cpb) after heart surgery, a child's blood is exposed to many foreign entities. these conditions trigger the body's inflammatory response which results in leaky capillaries, increased swelling and possibly organ dysfunction. since the early 1990's, modified ultrafiltration (muf) has been shown to decrease excess swelling, reduce bleeding, improve heart function, and decrease hospital length of stay. angiopoietins are a family of proteins necessary for both normal and abnormal blood vessel formation. they also appear to play a role in capillary leak. though muf has been shown to improve clinical outcome following cpb, there continues to be conflicting reports whether this is a result of the filtration of inflammatory proteins or simply from excess fluid removal. since angiopoietins appear to play a role in both inflammation and capillary leak, the investigators hypothesize that the benefit seen after muf is also secondary to its ability to filter out these proteins, especially angiopoietin-2.

during cardiopulmonary bypass (cpb) for corrective or palliative congenital heart surgery, a child's blood is subjected to hemodilution, hypothermia, nonpulsatile blood flow and exposure to foreign and non-endothelialized surfaces. these non-physiologic conditions trigger the host's innate systemic inflammatory response which results in capillary leak, increased total body water and can lead to end organ dysfunction. since the early 1990's, modified ultrafiltration (muf) has been shown to decrease excess tissue edema, reduce postoperative bleeding, improve cardiac contractility, maintain hemodynamic stability, and decrease hospital length of stay. angiopoietins are a family of vascular growth factors necessary for both normal and abnormal blood vessel formation and appear to play a role in capillary leak. though muf has been shown to improve clinical outcome following cpb, there continues to be conflicting reports whether this is a result of the filtration of inflammatory cytokines or simply excess fluid removal. since angiopoietins appear to play a role in both inflammation and capillary leak, the investigators aim to determine whether muf's clinical benefit is also secondary to its ability to filter out these molecules, more specifically angiopoietin-2.

Eligibility criteria:
inclusion criteria: * pediatric patients with congenital heart disease undergoing surgical intervention requiring cardiopulmonary bypass and modified ultrafiltration. exclusion criteria: * any patients with congenital heart disease who will not require modified ultrafiltration.

Keywords: children congenital heart defects cardiopulmonary bypass modified ultrafiltration angiopoietins cytokines
comparison of the efficacy of phenol block and corticosteroid-local anesthetic block applied to the genicular nerve

Conditions: Knee Osteoarthritis

Summary: there are different neurolysis methods. aim of this study is to compare two different methods, phenol block and corticosteroid local anesthetic block.

knee osteoarthritis is one of most frequent reason of knee pain. there are different treatment methods such as analgesic drug treatment, physical therapy techniques, intraarticular injections and neurolysis techniques. in this study, we will compare neurolysis techniques these are phenol block and corticosteroid local anesthetic block.

Eligibility criteria:
inclusion criteria: * patients with knee osteoarthritis must have pain at least 6 months * nrs score of knee pain equal or more than 5 * at least grade 3 in kellgren-lawrence grading scale * non responsive to life style change, weight control, exercises program, medical treatment and the other conservative treatments (physical therapy, intraarticular injections) * decreasing at nrs score more than %50 after diagnostic block * those who accept the consent form exclusion criteria: * patients who have acute knee injury * surgery history in knee * connective tissue disease that affect knee * sciatica * injection story in last 3 months * psychiatric or neurologic diseases that affect study * septic arthritis, active local or systemic infection * coagulopathy * pregnancy * allergic reaction

Keywords: genicular nerve phenol knee osteoarthritis neurolysis nerve blockage
long-term follow up of adult patients treated with extracorporeal membrane oxygenation for respiratory failure

Conditions: Long Term Adverse Effects; Pneumonia; Acute Respiratory Distress Syndrome; Sepsis; Critical Illness; Cognitive Impairment; Extracorporeal Circulation; Complications

Summary: follow-up after treatment with extracorporeal membrane oxygenation (ecmo) at the ecmo center karolinska. patients: adult survivors treated with ecmo for severe refractory respiratory failure at least 5 years earlier. investigations: brain and pulmonary radiographic morphology, cognitive testing, pulmonary function testing, exercise tolerance, quality of life and mood disorder screening.

all adult patients treated at the ecmo center karolinska between 1995 and july 2009 were screened for eligibility in january 2014. patients living abroad (including non-swedish citizens), patients treated for non-respiratory conditions, diseased patients and patients with a known pre-ecmo mental handicap were excluded. eligible patients were contacted, and patients who agreed to participate gave their written informed consent. all studied patients underwent the same study protocol during a day at the hospital, including a clinical interview, mri scan of the brain, hrct scan of the thorax, pulmonary function testing, neuropsychological examination, walking test, self assessment questionnaires for quality of life, anxiety, depression and post-traumatic stress. patient charts were reviewed for relevant clinical information, including age, gender, ecmo mode (venovenous or venoarterial), time in hospital, on ecmo, non-ecmo icu and on mechanical ventilation; preexisting diseases, blood gas values and ventilator settings before initiation of ecmo treatment. hand written clinical data from the patients´ charts from every hour with ecmo treatment was reviewed for ventilator settings, lung volumes, mean arterial pressure, hemoglobin, lactate and oxygenation parameters during an observation period, which was defined as the first 10 days on ecmo (or the entire treatment period if shorter than 10 days). this information was added to a digital database for the purpose of this study. at the time of ecmo treatment, arterial hemoglobin oxygen saturation was measured by peripheral pulse oximetry from the right ear, finger or nose. venous preoxygenator lactate and venous saturation values were used as indicators of sufficient (lactate \< 2 mmol l-1 , svo2 ≥ 70%) or insufficient tissue perfusion.

Eligibility criteria:
inclusion criteria: * adult patients treated with ecmo at the ecmo center karolinska 1995 - july 2009 exclusion criteria: * diseased patients * patients living abroad (including non-swedish citizens) * patients treated for non-respiratory conditions * patients with a known pre-ecmo mental handicap

Keywords: extracorporeal circulation critical care outcomes
investigation of the effect of short-term orthokeratology with increased compression factor on ocular parameters

Conditions: Myopic Progression

Summary: orthokeratology (ortho-k) is a clinical technique that uses reverse geometry rigid gas permeable contact lens exerting positive pressure on the central cornea to temporary reduce refractive error. researchers have shown that this treatment is effective for myopia control in low to high myopes, with and without astigmatism. most designs of ortho-k lenses in the market are fitted based on the jessen formula. the compression factor was introduced to compensate for the regression of the ortho-k effect during the no lens-wear period, so that the wearer can obtain clear distance vision throughout the day and most lens designs use a compression factor of 0.50-0.75 d. however, in a retrospective study (mixed brands of ortho-k lenses), it showed that most patients did not achieve an over-correction of 0.75 d. in order to achieve an over-correction of 0.75 d, an extra flattening power of about 1.50 d instead of 0.75 d should be be targeted. the increased compression factor is expected to increase the target reduction and it may play a role in myopic control and providing a higher successful rate in fitting ortho-k lenses.

subjects were fitted with ortho-k lenses of conventional (0.75 d) and increased (1.75 d) compression factor. the laterality of the compression factor for each subject was randomised. subjects were instructed and trained with proper lens handling and disinfection procedures. lenses were given to the subjects only when they demonstrated proper techniques. all subjects were required to attend regular follow-ups (baseline, first overnight, and weekly over one-month period). the follow-ups were scheduled (except for the first overnight which was scheduled in the early morning) at a similar time to the baseline visit (+/- 2 hours) to minimise any potential influence of diurnal variation on ocular biometrics. additional unscheduled visits were provided when necessary to ensure good ocular health and vision throughout the study period.

Eligibility criteria:
inclusion criteria: 1. 6 to 10 years old 2. myopia: between 0.50 d and 4.00 d in both eyes 3. astigmatism: \<1.50 d; ≤ 1.25 d for with-the-rule astigmatism (axes 180 ± 30); ≤ 0.50 d for astigmatism of other axes in both eyes 4. anisometropia: ≤ 1.50 d 5. symmetrical corneal topography with corneal toricity \<2.00 d in both eyes 6. agree for randomization exclusion criteria: 1. contraindications for orthokeratology wear (e.g. limbus-to-limbus corneal cylinder and dislocated corneal apex) 2. any type of strabismus or amblyopia 3. myopic treatment (e.g. refractive surgery and progressive lens wear for myopic control) before and during the study period 4. rigid contact lenses (including orthokeratology lenses) experience 5. systemic condition which might affect refractive development (for example, down syndrome, marfan's syndrome) 6. ocular conditions which might affect the refractive error (for example, cataract, ptosis) 7. poor compliance for lens wear or follow-up

Keywords: myopia control orthokeratology
efficacy and safety of ethanol lock therapy for the prevention of central line-associated bloodstream infections

Conditions: Catheter-Related Infections

Summary: patients on long-term parenteral nutrition (pn) are at high risk for central line-associated bloodstream infections (clabsi). this study evaluates the efficacy and safety of ethanol lock therapy for clabsi prophylaxis in adult patients on pn.


Eligibility criteria:
inclusion criteria: * adult patients (ages 18-80) on pn with silicone-based central venous catheters exclusion criteria: * weight ≤ 50 kg * allergy/hypersensitivity/intolerance to ethanol or heparin * pregnancy or breastfeeding * patient taking metronidazole, disulfiram, or isoniazid * history of alcohol abuse * history of heparin-induced thrombocytopenia (hit) or have an active hypocoagulable state

Keywords: ethanol lock parenteral nutrition
s-ketamin premedication in pediatric eent surgery

Conditions: Emotions; Separation Anxiety; Pain, Procedural

Summary: we aim to investigate the effects of premedication (intranasal or intravenous administration) of s-ketamin, dexmedetomidine, and combination for premedication in children undergoing ent surgery.

three hundred children aged between 2 and 12 years were randomly allocated to one of five groups: 0.3 μg/kg intravenous injection s-ketamin; 0.5 μg/kg intravenous injection s-ketamin; 2 μg/kg intranasal s-ketamin group; 1 μg/kg intranasal s-ketamin + 1 μg/kg intranasal dexmedetomidine group; 0.5 μg/kg intranasal s-ketamin + 2 μg/kg intranasal dexmedetomidine group. the modified yale preoperative anxiety scale (m-ypas) was used to assess preoperative anxiety at 1, 5, 10, 20, and 30min after premedication. a 4-point emotional state score was used to evaluate participators when they were separated from their parents and their response to intravenous cannulation or facemask application. agitation scores (pediatric anesthesia emergence delirium \[paed\] scale) and pov was assessed in the postanesthetic care unit (pacu). times to endotracheal tube or laryngeal mask airway removal, discharge from the pacu, and patients' satisfaction degree were also assessed.

Eligibility criteria:
inclusion criteria: * after obtaining the informed consent from their parents or proxies, the children aged 2 to 12 years, scheduled for elective ent surgery, of american society of anesthesiologists (asa) i or ii were enrolled in this study. exclusion criteria: * congenital heart diseases, congenital dysplasia, obstructive sleep apnea syndrome, upper respiratory tract infection, body mass index (bmi) ≥25, allergy to s-ketamin or dexmedetomidine, and severe liver or kidney disease.
systemic lupus erythematosus (sle) prospective observational cohort study (spocs)

Conditions: Systemic Lupus Erythematosus

Summary: spocs is an international, multicenter, prospective observational cohort study with bi-annual study visits over a 3-year follow-up designed to systematically describe the comprehensive sle patient-journey regarding clinical features, disease progression and treatment patterns, sle outcomes, health status assessments (pros), and health care resource utilization (hcru) in a general population of moderate-to-severe sle patients.

spocs is an international, multicenter, prospective observational cohort study with bi-annual follow-up over 3-years maximum follow-up of patients with sle confirmed by american college of rheumatology (acr) or systemic lupus international collaborating clinics (slicc) classification criteria, who have moderate-to-severe disease by sledai-2k criteria (modified sledai-2k score ≥4 and/or sledai-2k score ≥6 points, at least one life-time positive serology of anti-nuclear antibody (ana) or double-stranded deoxyribonucleic acid antibody (dsdna), and 6-month minimum treatment duration with systemic sle treatment beyond nsaids and analgesics. participants will be followed as per local routine clinical practice. spocs is an observational study with no requirement for protocolized treatment interventions.

Eligibility criteria:
inclusion criteria: patients must meet the following criteria for enrollment in spocs: * adult patients aged 18 years or older * physician confirmation that patient meets acr or slicc sle classification criteria * current or historic positive serology of ana or dsdna * minimum treatment duration of 6 months for active sle with systemic sle treatment beyond nsaids and analgesics * moderate-to-severe sle; sledai-2k criteria: modified sledai-2k score ≥4 and/or sledai-2k score ≥6. the "modified" sledai-2k is the sledai-2k assessment score without the inclusion of points attributable to any urine or laboratory results including immunologic measures and lupus headache. * patient and/or representative(s) who understands the requirements of the study and provides written informed consent. exclusion criteria: patients meeting any of the following criteria will be determined to be ineligible for enrollment in spocs: * patients actively enrolled in interventional trials involving investigational agents * patient with active severe lupus nephritis with a history of a renal biopsy in the last year showing active class iii or class iv +/- class v lupus nephritis and/or urine protein:creatinine ratio \>1mg/mg based on random urine collection. * patients unable to complete study measures

Keywords: systemic lupus erythematosus disease
evaluation of the outcome of covid-19 patients discharged home on oxygen therapy

Conditions: COVID-19

Summary: the rené dubos hospital in pontoise has set up a home discharge system for oxygen-requiring patients in collaboration with prado, a health insurance organization, or private providers. this organization coordinates the care to be implemented at home based on the city/hospital link. the coordinator of this organization was also in charge of scheduling a follow-up consultation between 7 and 14 days after hospital discharge. the aim of this study is to evaluate this new organization, both in terms of its impact on patient outcomes (survival and re-hospitalization rates) and on patients' experiences and satisfaction with their care.

the covid-19 pandemic was responsible for an unprecedented hospital tension with multiple consequences (medical, economic, social...). the first scientific responses were found with unprecedented speed. very quickly, innovative solutions and a complete reorganization of the health system were necessary to manage this crisis. in order to limit the number of patients hospitalized and/or the length of their hospitalization, most hospitals quickly set up systems to organize the early return of patients to their homes on oxygen. studies evaluating telemedicine as a tool for monitoring oxygen-requiring patients at home have shown that it is effective and safe for monitoring these patients. another retrospective study estimated the 30-day rehospitalization rate for patients with sars-cov-2 pneumonia after return home on oxygen with telephone monitoring by a nurse to be 8.5% (95% confidence interval, 6.2%-10.7%) and all-cause mortality to be 1.3% (95% confidence interval, 0.6%-2.5%). the rené dubos hospital in pontoise has set up a home discharge system for oxygen-requiring patients in collaboration with prado, a health insurance organization, and a private provider. these organizations coordinate the care to be implemented at home based on the city/hospital link (oxygen provider, private nurse for the injection of anticoagulants and sometimes insulin and monitoring of vital parameters). these organizations were also in charge of scheduling a follow-up consultation between 7 and 14 days after hospital discharge, with the attending physician or, failing that, in the infectious diseases department of the pontoise hospital.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age * patients with virologically proven covid 19 (positive polymerase chain reaction or antigenic test) or based on clinical and radiological evidence * patients discharged from hospital or from the emergency room on oxygen between 1 and 5l at the time of discharge * organization of discharge by a service provider (prado or private) exclusion criteria: * patients discharged from the intensive care unit * oxygen-requiring patients \> 5 liters

Keywords: covid-19 oxygen therapy early return