effect of early versus delayed postoperative feeding in lower limb fracture surgery

Conditions: Lower Limb Fracture

Summary: the treatment of lower limb fracture accounting one third of total fracture is a complex problem for the surgical and rehabilitation team. patients are kept in long term fasting after surgery to prevent from postoperative complications, but it leads to the surgical catabolism resulting delaying the desired improvement in patients. to our knowledge, it has not been widely implemented in clinical settings. therefore, the aim of the study is to evaluate the effect of early versus delayed postoperative oral feeding in lower limb fracture surgery under regional block anesthesia. this study utilize single-center, hospital based, open-label, parallel group randomized controlled trial to assess the effect of early postoperative oral feeding in two hours after the surgery over the conventionally delayed feeding. a representative sample size of 275 patients (control group=138 and study group =137) aged 18 years and above having lower limb fracture operated under regional block will be selected for research. the pre-operative nutritional status will be identified with simplified nutritional appetite questionnaire (snaq) and the post-operative outcomes will be measured by numerical rating scale (nrs) system. preoperative as well as postoperative hand grip strength and neutrophil lymphocyte ratio (nlr) will be assessed. statistical analysis will be performed using chi square test, student two sample t-test to compare between the outcome of study and control groups. the outcome of the study may provide an empirical evidence to the anesthesiologists and surgeons towards the emerging concept of postoperative early oral feeding practice in lower limb fracture surgery in clinical settings.

orthopedic conditions are the physical injuries related to the musculoskeletal system of an individual. the overall incidence of musculoskeletal injury in low- and lower-middle income countries (lmics) range from 779 to 1574 per 100,000 person-years. fracture is one of the main cause of injury showing 1,229 per 100,000 individuals. the most common injury due to the road traffic accident was the 69 % fracture with fractures of tibia/fibula accounted as 30.3%. the road traffic injury (rti) in nepal for the period 2001-2013 also revealed that the most common fractures are lower extremities and upper extremities. about one third of the total fracture accounted for lower limb fracture and its complications lead to reason for hospital stay. surgical management for the lower extremities fracture allows quick stabilization of fractures and early mobilization, hence accelerates the return to usual daily life activities. in fact, lower extremities fracture is a complex problem for the surgical and rehabilitation team. pain as postoperative outcome is associated with many factors like age, duration of surgery, type of surgery, site of surgery, use of anesthesia, ethnicity, and others. nutritional status is a strong predictor of postoperative outcomes in orthopedics for the preservation of muscle mass, strength and functionality of movement, and therefore it is recognized as an important component of surgical recovery programs. nutritional assessment includes subjective as well as objective parameters. there are many tools for examining malnutrition and nutritional assessment as subjective parameters. similarly, different laboratory markers such as albumin, pre-albumin, total lymphocytes, total cholesterol, c-reactive protein, transferrin are considered the objective parameter for the nutritional status evaluation. higher the pre- and postoperative neutrophil lymphocyte ratio (nlr) is associated with a higher long-term mortality risk in hip fracture surgery in elder people. nutritional intervention is crucial for enhanced recovery after surgery. preoperative carbohydrate loading as nutritional intervention is one component of enhanced recovery after surgery (eras) which reduces insulin resistivity and postoperative infection. another study found that preoperative carbohydrate loading in femur fracture has facilitated the ambulatory function, reduced the postoperative pain and hence reduced the length of hospital stay. patients are kept in long term fasting after surgery to prevent from postoperative complications. in fact, postoperative fasting leads to surgical catabolism and has increased the icu stay among cancer patients undergoing elective cancer surgery. early feeding after surgery challenges the concept of increased incidence of nausea and vomiting, and so late re-feeding has no advantages. immediate postoperative re-feeding in orthopedic surgery is safe. earlier post-operative feeding reduce the infection complications, improve healing, and decrease length of stay, so oral feeding should be resumed as soon as possible after surgery, with the goal of returning to solid foods within 24 hours. previous study found that around 25 gram of essential amino acid can be fed orally within 30 minutes after surgery to facilitate the injury recovery and rehabilitation among athletes. a randomized controlled trial shows that early postoperative feeding at 4 hours is safe, and the traditional policy of starting feeding after 8 hours is outmoded under general anesthesia in orthopedics. the recommendation 5 of european society for clinical nutrition and metabolism (espen) which states that enteral feeding can be initiated immediately after surgery. however, postoperative patients are mostly re-fed only after 4-6 hours of the surgery followed by the regional anesthesia (spinal, epidural or nerve block). therefore, the study is intended to evaluate the effect of early postoperative oral feeding in the lower limb fracture surgery under regional block anesthesia.

Eligibility criteria:
inclusion criteria: * patients aged 18 to 60 years undergoing the lower limb fracture surgery under regional anesthesia * intermediate to major categories of surgeries * american society of anesthesiologists (asa) i and ii exclusion criteria: * cognitive dysfunction * pathological fracture * fracture more than one site * redo/follow-up surgery * unanticipated intraoperative complications * use of intraoperative drugs that causes the postoperative nausea and vomiting * gastrointestinal disorder such as peptic ulcer, hiatus hernia, peptic ulcer, irritable bowel syndrome or esophagitis * history of gastrointestinal surgery

Keywords: postoperative diet early feeding delayed feeding lower limb fracture