Kornimate/medical-research-clean huggingface dataset:
pilates program in female adolescent with eating disorders

Conditions: Eating Disorder; Female Adolescents

Summary: physical exercise helps patients with eating disorders by improving their physical fitness, quality of life and other specific variables of this pathology. pilates has a beneficial effect both physically and mentally on healthy population and other diseases. in patients with eating disorder, pilates will improve psychic aspects and their physical condition. for all these reasons, the affectation of psychological symptoms will decrease and the quality of life will improve.


Eligibility criteria:
inclusion criteria: * 1) clinical diagnosis of eds in the aforementioned hospital; * 2) aged from 10 to 17 years old; * 3) written informed consent by the patients and their legal guardians exclusion criteria: * 1) have other diagnoses of mental illness or * 2) consumption of narcotic toxins
umbilical cord blood mononuclear cell transplant to treat chronic spinal cord injury

Conditions: Spinal Cord Injuries

Summary: the purpose of this study is to investigate the feasibility, safety, efficacy and optimal dose of umbilical cord blood mononuclear cell transplant in the treatment of chronic spinal cord injuries.

this is an open-label dose-escalating clinical trial. 20 patients will be randomly divided into 5 groups, 4 patient per group. the first three groups of four patients will receive transplants of increasing dose of hla-matched umbilical cord blood mononuclear cells, starting from 4 spinal cord injection of 4µl of cell suspensions in group a to 8µl in group b and 16µl in group c. if more than one subjects show neurological loss attributable to the cell injections, the trial will fall back to the previous dose. in the group d, the highest volume of cells that do not cause neurological deficits (e.g. 16µl x4) along with a single bolus of 30 mg/kg methylprednisolone sodium succinate (mpss) will be provided. subjects in the group e receive the same treatment as group d plus a 6-week course of oral lithium carbonate. all subjects will enroll for three months intensive rehabilitation after the cell transplant.

Eligibility criteria:
inclusion criteria: * subjects with chronic spinal cord injury (\>12 months post-initial spinal cord injury surgery) with stable neurologic findings for at least 6 months * subjects with current neurological status of asia a * the neurological level of the subjects is between c5 and t11 * the injured site of the spinal cord is within three vertebral levels * subjects must be able to read, understand, and complete the vas * subjects who have voluntarily signed and dated an informed consent form prior to any study procedures. exclusion criteria: * significant renal, cardiovascular, hepatic and psychiatric diseases * significant medical diseases or infection * pregnant or lactating woman * female of childbearing potential and who is unwilling to use an effective contraceptive method while enrolled in the study * the length of spinal cord lesion exceeds three segments * unavailability of hla matched umbilical cord blood cells * any contraindication of laminectomy operation, methylprednisolone and/or lithium carbonate * subject who is currently participating in another investigational study or has been taking any investigation drug within the last 4 weeks prior to screening of the study * in opinion of the investigator, who suggests that the subject would not be compliant with the study protocol and/or would not be suitable to participate the study

Keywords: spinal cord injury umbilical cord blood mononuclear cell lithium carbonate
post-extubation assessment of clinical stability in elbw infants

Conditions: Extremely Low Birth Weight Infants

Summary: this is an observational, proof-of-concept, feasibility study that aims to evaluate the feasibility of a monitoring system that integrates clinical data, high-resolution waveforms from the bedside monitor, regional oxygenation (via cerebral and splanchnic near-infrared spectroscopy), and regional ventilation (via electrical impedance tomography) from 20 extremely low birth weight infants at high-risk of reintubation.

the primary aim of this proof-of-concept study is to evaluate the feasibility and acceptance of a monitoring system that integrates clinical data and biomedical signals from multiple modalities in a cohort of extremely preterm infants at high-risk of clinical instability on non-invasive respiratory support. secondary aims will be to longitudinally describe peripheral oxygen saturation, cerebral oxygen saturation, splanchnic oxygen saturation and regional lung ventilation in extremely low birth weight infants with or without reintubation during the 7 days post extubation. the application of this multimodal monitoring approach using both clinical and physiological data during the postextubation period will help by making the assessment of clinical stability more comprehensive, more objective, more accurate, more standardized, and more reflective of important end-organ function. thus, the proposed multimodal monitoring could lead to more informed decisions about reintubation and more individualized treatment plans during this critical period, hence potentially leading to better outcomes.

Eligibility criteria:
inclusion criteria: * birth weight \< 1000g and gestational age \< 28+0 weeks, * received mechanical ventilation within the first 72h of life, * undergoing their first planned extubation within the first 6 weeks of life. exclusion criteria: - congenital anomalies and congenital heart disorders.

Keywords: reintubation extubation extremely low birth weight infants electrical impedance tomography cerebral and splanchnic oxygenation near infrared spectroscopy apnea intermittent hypoxia
prognostic impact of sleep disorders in patients : pro-tsic study

Conditions: Heart Failure; Sleep Disorder; Insomnia

Summary: heart failure (hf) is a common and progressive condition associated with significant morbidity and mortality. only 25-35% of patients survive 5 years after diagnosis.sleep disorders are frequently found in this population with up to 94% of patients complaining of sleep disorders. of these, insomnia and sleep disorders are the most common. the frequency of restless legs syndrome (rls) varies between 4 and 40% depending on the studies. patients with hf frequently experience poor sleep quality which is associated with deterioration in quality of life, alertness, and mood. few studies have examined the prognostic impact of sleep disturbances in this population. a greater morbidity and mortality is observed in the event of poor quality sleep or in the presence of sleep breathing disorders . the investigators therefore propose to evaluate the sleep disorders of patients with hf by self-administered questionnaires, hypothesizing that complaints of poor sleep are linked to a poorer cardiovascular prognosis.


Eligibility criteria:
inclusion criteria: - heart failure according to the 2016 criteria of the european society of cardiology. exclusion criteria: - age less than 30 years
auditory functions in patients with multiple sclerosis

Conditions: Multiple Sclerosis; Hearing Disorders

Summary: the study will analyze the auditory functions of patients with multiple sclerosis using auditory tests like pure tone auditory test, speech perception test, auditory brain response (abr) and distortion product otoacustic emission (dpoae). csf will be collected by lumbar puncture and analyzed looking for inflammatory markers. the results of dpoae and csf will be correlated to identify statistically significant correlation.

case-control study tools for patients' selection and inclusion in the study step one * full medical records detailed for neurological diseases * brain and spinal cord mri performed 12 months (n1) before and most recent one (n2) * lumbar puncture * blood test * questionnaire for screening hearing disorders * app for screening hearing loss step two * pure tone auditory test + tympanometry and stapedial reflex * speech perception test * in case of tinnitus: tinnitus questionnaire and acuphenometry * dpoaes * abr step three in case of hearing impairment - mri tractography

Eligibility criteria:
inclusion criteria * age \>18 and \<50, * no history of hearing loss, * no psychiatric condition * no familial history of otosclerosis/deafness/genetic hearing loss * patients with pd and/or ms. exclusion criteria * conductive hearing loss * stroke \< 2 years * cardiovascular disease non under control * diabetes * hypotensive disorders * alcohol abuse * recreational drug consumption * epilepsy
parkinstim: transcranial direct current stimulation for parkinson's disease

Conditions: Parkinson's Disease

Summary: the purpose of this study is to evaluate the effects of transcranial direct current stimulation (tdcs) on patients with parkinson's disease during sleep.

the clinical study will follow a counterbalanced crossover design during which subjects will undergo two separate pairs of two-consecutive-overnight sleep studies and receive anodal tdcs (active or sham) to m1. the first sleep study in each pair will acclimate subjects to the sleep laboratory and minimize "first night" effects, thus no tdcs will be applied. the second sleep study in each pair will include active or sham tdcs, presented in a pseudorandom order such that approximately half of the subjects receive active tdcs first while the other half receives sham first. the two pairs of sleep studies will be separated by one to three weeks.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of idiopathic parkinson's disease (pd) according to the uk pd brain bank criteria * hoehn and yahr stage ii-iii when off anti-parkinsonian medication * able to provide informed consent * currently taking levodopa (300-800 mg per day) * on stable regimen of anti-parkinsonian medication for at least one month before study entry and able to continue on a stable regimen for the duration of the study * presence of early morning akinesia * naïve to tdcs. exclusion criteria: * children will be excluded from this study due to the fact that they are unlikely to have pd * significant medical or psychiatric illness, significant neurological disease other than pd, metal objects and/or deep brain stimulators in the head that might pose a hazard during tdcs * dementia, as evidenced by a score less than 26 on the montreal cognitive assessment * significant depression (geriatric depression scale score \< 20) * presence of hallucinations * having undergone any surgical procedure for treatment of pd including deep brain stimulation (dbs), pallidotomy, thalamotomy, or other brain surgeries * a history of seizures * a known history of severe sleep apnea or sleep onset insomnia * skin diseases that could potentially cause irritations under electrodes

Keywords: parkinson's disease transcranial direct current stimulation
a trial evaluating safety of chronic therapy with certolizumab pegol in crohn's disease

Conditions: Crohn's Disease

Summary: the primary aim of this study is allow the patients suffering from crohn's disease , who both completed the therapeutic confirmatory study c87055 of certolizumab pegol and benefited from the treatment, to receive treatment with certolizumab pegol until the drug is available for the crohn's disease indication in greece.


Eligibility criteria:
inclusion criteria: * crohn's disease diagnosis * patients having completed the treatment period of study c87055 (previously treated with infliximab) and benefited from the study treatment, as per investigatior's discretion. exclusion criteria: * subject withdrawn prematurely from c87055 study. * subject who received treatment other than certolizumab pegol and other than medications permitted in c87055 study. * female patients of childbearing age who are not practicing (in the investigator's opinion) effective birth control. all female patients must test negative on a serum pregnancy test before study entry and negative on urine testing immediately before every certolizumab pegol administration.

Keywords: certolizunab pegol long term safety follow-up chrohn's disease infliximab failures patients greek population
evaluation of the impact of eating habits on children's corpulence

Conditions: Obesity, Childhood

Summary: childhood obesity has been rising steadily over the past 40 years. in 2016, the world health organization (who) observed around 340 million overweight or obese children and adolescents worldwide, including one in five in france. the causes are complex, both individual (genetic, biological, behavioral) and collective (social, economic, cultural). childhood obesity encourages the development of chronic diseases such as diabetes and hypertension, and can affect mental health. without early treatment, the risk of obesity persisting into adulthood is high. in the alpes-maritimes region, the commune of mouans-sartoux has been promoting a local diet in line with pnns-4 recommendations since 2011. we wish to study the impact of these actions on the health of mouans children. we propose a preliminary observational study to assess the relationship between family adherence to pnns recommendations and the prevalence of overweight and obesity in mouans-sartoux elementary school children.


Eligibility criteria:
inclusion criteria: * the child must be enrolled in one of mouans-sartoux's three public elementary school (a. legall / f. jacob / orée du bois) at the start of the 2023 school year * social security affiliation * non-opposition of the legal representative(s) of parental authority exclusion criteria: * opposition to participation in research involving the human person * in the event of disagreement between the parents, we will take non-participation into account

Keywords: child obesity alimentation nutrition
scalp nerve block on emergence agitation

Conditions: Agitation

Summary: emergence agitation is a common problem in children during recovery from sevoflurane anesthesia. pain is considered as a cause of postoperative emergence agitation and compounding factor of agitation assessment in children. the purpose of this study was to investigate the effect of scalp nerve block on the emergence agitation in children undergoing nevus surgery during sevoflurane anesthesia.

forty-four children, 1-7 years old, undergoing nevus surgery on head were enrolled. anesthesia was induced with thiopental sodium and rocuronium, and maintained with sevoflurane. patients were randomly assigned two groups: the control group received iv remifentanil 1 μg/kg, and the block group received scalp nerve block with 0.25% ropivacaine 2-3 ml. time to tracheal extubation, recovery time, hemodynamic change, flacc score, and watcha behavior scale for emergence agitation were assessed.

Eligibility criteria:
inclusion criteria: * asa i-ii patients undergoing general anesthesia for nevus surgery exclusion criteria: * developmental disorder * neurologic disorder * coaguloparthy * allergy to local anesthetics
interdisciplinary + intersectoral telemedicine evaluation, coordination + treatment in rhinemain+ parkinson's network

Conditions: Parkinson Disease

Summary: project objective: to improve the health care of parkinson's disease patients in the parkinsonnetz rheinmain+. hypothesis: through the interdisciplinary and cross- sectoral networking in a tele medical network and the coordinating function of an "advanced practice nurse" (apn) specially trained for parkinson's disease, the process quality within the network is increased and the individual health status is positively influenced.

to effectively influence the long-term course of parkinson´s a synergistic application of an individualized therapy program, which is tailored specifically to the symptoms and disease stages, is needed. the central element of the new form of care is the implementation of a tele medical evaluation and coordination function, which controls individualized treatment processes within the network. the individualized evaluation and coordination of treatment paths is carried out within the already existing parkinson's network rheinmain+ by a non-physician medical specialist (apn) specially trained for the indication parkinson's disease. in-depth assessments of the individual disease situation of the patients will take place. based on these assessments, an evidence-based and patient-centered treatment and care plan is developed. the treatment plans are monitored, controlled and evaluated by the apns using audiovisual or tele medical communication. in addition, apns are empowered to initiate treatment interventions necessary to implement clinical guidelines and standards, and to take charge of these interventions as part of delegation processes. the apns ensure that patients are cared for in accordance with needs and guidelines in all areas of care. to this end, they offer, among other things, training in the handling of patients with parkinson's disease for other professional groups involved in the treatment process and not only have the patients in mind, but also include relatives and the supporting team.

Eligibility criteria:
inclusion criteria: * diagnosis of primary parkinson's syndrome (g20.-) or atypical parkinson's syndrome (g23.-, according to the current diagnostic criteria of the movement disorder society, including the criteria of at least bradykinesia and rigidity or resting tremor must be present) * in the care regions of hesse and rhineland-palatinate * ability to give consent present exclusion criteria: - severe dementia * severe depression * psychoses or other psychiatric or medical comorbidities that could affect the smooth implementation of the study protocol (e.g. tumor disease with limited life expectancy, need for dialysis, etc.) * drug or alcohol addiction * women who are pregnant or breastfeeding * simultaneous participation in another interventional treatment study * illiteracy or insufficient language skills

Keywords: parkinson disease, advanced practice nurse, telemedical, interdisciplinary, cross-sector care networks and pathways.
investigation of low-intensity focused ultrasound pressure

Conditions: Somatic Pain

Summary: investigating the relationship between input pressure of low-intensity focused ultrasound and an evoked potential in both eeg and fmri.

study aims to determine safety and efficacy of variable pressures of low-intensity focused ultrasound using an electrical stimulation to create a somatosensory evoked potential and record eeg and fmri outcome measures. a primary safety study will be conducted prior to 'full scale' data collection.

Eligibility criteria:
inclusion criteria: understand and speak english exclusion criteria: 1. claustrophobia (scanning environment may be uncomfortable). 2. contraindications to mri: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants. 3. contraindications to ct: pregnancy 4. active medical disorder or treatment with potential cns effects (e.g. alzheimer's) 5. history of neurologic disorder. (e.g. parkinson's, epilepsy, or essential tremor) 6. history of head injury resulting in loss of consciousness for \>10 minutes. 7. history of alcohol or drug dependence (through self-report).
genesis electrical impedance tomography (eit): a preliminary study

Conditions: Premature Infant; Chronic Respiratory Disease; Neuromuscular Diseases; Healthy; Bronchopulmonary Dysplasia; Pulmonary Vein Stenoses

Summary: the purpose of this study is to evaluate the genesis electrical impedance tomography (eit) imaging system for use in pediatric respiratory disease populations including neuromuscular and bronchopulmonary dysplasia, as well as in age and height matched controls. the eit does not use radiation, and is read through electrodes.

the purpose of this study is to evaluate eit for use in pediatric respiratory disease populations including neuromuscular and bronchopulmonary dysplasia, as well as in age and height matched controls. researchers will use eit to determine changes in regional ventilation with pulmonary interventions including airway clearance and invasive and noninvasive ventilation in a pediatric respiratory disease population.

Eligibility criteria:
inclusion criteria: * 2 weeks old - 40 years old * premature infants with current age \>2 weeks with a confirmed diagnosis of bpd based on nih criteria * or chronic respiratory disease due to underlying neuromuscular disease * or confirmed neuromuscular disease with an echo completed within the preceding 12 months of study participation of dmd or other diagnoses associated with mild cardiomyopathy. * have had a vq scan * will be undergoing cardiac catherization for for pulmonary vein stenosis, pulmonary hypertension and/or pulmonary artery stenosis * or healthy controls exclusion criteria: * \<2 weeks of age * congenital diaphragmatic hernia * severe congenital heart disease * significant genetic abnoralities * anything that interferes with lead placement on the chest wall * unwilling/refusal to sign consent * pregnant or lactating * pacemaker of other surgical implant and spinal implant (causes noise in the data) * moderate to severe cardiomyopathy * patients with temporary cognitive disability due to illness
phenotypic heterogeneity in hemophilia a: an investigation of the role of platelet function

Conditions: Hemophilia A

Summary: the is study will examine whether variation in clinical bleeding frequency and severity among boys with severe hemophilia a (factor viii deficiency) is associated with variations in laboratory measurements of platelet activity.


Eligibility criteria:
inclusion criteria: * documented circulating fviii level of ≤1% * age 3 - 20 years * may be on primary or secondary prophylaxis * granting of informed consent exclusion criteria: * measurable inhibitor level at the time of enrollment * ingestion of aspirin/supplement known to influence platelet function within 14 days of blood sampling, or ibuprofen within 3 days
percutaneous tibial nerve stimulation (ptns) for the treatment of chronic anal fissure

Conditions: Fissure in Ano

Summary: chronic anal fissure rarely heals spontaneously. about 50% heal on administration om topical muscle relaxants (e.g. diltiazem) and/or injection of botulinum toxin, but for the remainder of patients surgery (with lateral internal sphincterotomy or fissurectomy) with subsequent risks of anal incontinence has been the golden standard. treatment with ptns (percutaneous tibial nerve stimulation) has been showed to produce healing of chronic anal fissures not responding to topical treatment, thus avoiding the risk for debilitating anal incontinence.

this study will prospectively include 52 patients with chronic anal fissure that have received topical treatment and stool softeners and have all been evaluated by experienced proctological surgeons. the treatment will be given for 10 consecutive work days and then evaluated at 3 and 12 months. if the patients symptoms are unimproved at 3 months alternative treatments will be offered.

Eligibility criteria:
inclusion criteria: * verified anal fissure (clinical assessement by experienced proctological surgeon) * full conservative treatment has been given exclusion criteria: * inflammatory bowel disease * fistula and/or anal abscess * patients with compromised immunity * pregnancy * treatment with anti-coagulants (not aspirin) * previous irradiation towards pelvic floor * pacemaker or implanted defibrillator

Keywords: anal fissure percutaneous tibial nerve stimulation ptns