Kornimate/medical-research-clean huggingface dataset:
care plans for cancer predisposition

Conditions: Genetic Predisposition

Summary: develop and evaluate acceptability, feasibility, and preliminary efficacy of digital care plan and accompanying text message reminders for children and adolescents with a known cancer predisposition syndromes (cps).

as over 15% of pediatric cancers are associated with a cancer predisposition, it is increasingly becoming standard of care for children with cancer, as well as those with suspected hereditary risk, to be evaluated for germline cancer predisposition. unfortunately, the increase in pediatric genetic testing has exceeded the pace of research supporting effective cancer surveillance in positive cases. additionally, guidelines for cancer predisposition management are not easily accessed or understood by families; thus, there is often a disconnect between the understanding and retention of such information relayed to families. in this study, investigators will develop and evaluate the acceptability, feasibility, and preliminary efficacy of digital care plans for cancer predisposition syndromes (cps) with accompanying text message reminders for children and adolescents with a known cps. digital care plans and text messages will be created for 10 common cps. investigators will use a quasi-experimental design with pre and post testing of the same cohort, before and after delivery of care plan and accompanying messages. to evaluate the impact of the digital care plans, investigators will compare assessments of the same cohorts at 3 and 6 months time points.

Eligibility criteria:
inclusion criteria: parents 1. parent or legal guardian of a patient with a known cancer predisposition syndrome diagnosed within the last 5 years 2. received care at the cancer predisposition clinic at the children's hospital of philadelphia (chop), or other medical institutions (does not need to be receiving follow-up care at chop) 3. appropriate to approach per oncology team/cancer predisposition team 4. no cognitive impairment limiting ability to complete measures 5. ability to read and speak english fluently adolescent/young adult (aya) probands 1. child proband with a known cancer predisposition syndrome diagnosed within the last 5 years 2. ages 12+ 3. received care at the cancer predisposition clinic at the children's hospital of philadelphia (chop), or other medical institutions (does not need to be receiving follow-up care at chop) 4. appropriate to approach per oncology team/cancer predisposition team 5. no cognitive impairment limiting ability to complete measures 6. ability to read and speak english fluently exclusion criteria: * not meeting any of inclusion criteria

Keywords: genetic testing genetic counseling germline testing digital care plan cancer predisposition syndrome
pulmonary rehabilitation at home versus at the gymnasium

Conditions: COPD

Summary: short term efficacy of pulmonary rehabilitation for improving functional capacity and quality of life of chronic obstructive respiratory disease (copd) patient is well known. however, there is an important gap between the scientific knowledge and the clinical use of pulmonary rehabilitation since a a very small number of patients benefit from this therapeutic intervention. we estimate that less than 1% of the 750 000 canadians suffering from copd have access to a pulmonary rehabilitation program. we want to study the efficacy of a home-based rehabilitation program as a way to facilitate the access to rehabilitation.

this article on the main outcome is available. maltais f, bourbeau j, shapiro s, lacasse y, perrault h, baltzan m, hernandez p, rouleau m, julien m, parenteau s, paradis b, levy rd, camp p, lecours r, audet r, hutton b, penrod jr, picard d, bernard s. effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial. ann int med 2008;149:869-878.

Eligibility criteria:
inclusion criteria: * subject is able to ambulate. defined as a 6mwd greater than 110 meters. * subject is diagnosed with copd. * 40 years-old and older * currently or previously smoking with a smoking history of at least 10 pack-years. * forced expiratory volume on one second (fev1) after the use of a bronchodilator between 25 an 70% of the predicted value, and fev1 to forced vital capacity ratio less than 70%. * no previous diagnosis of asthma, left heart congestive heart failure (either radiographic evidence of pulmonary congestion, echocardiographic or ventriculographic evidence of a reduced ventricular ejection fraction), terminal disease, dementia or uncontrolled psychiatric illness. * never participated to a respiratory rehabilitation program and not staying or planning to stay in a long term care facility. * subject understands and is able to read and write french or english. * mrc dyspnea scale of at least 2. exclusion criteria: * the need for supplemental oxygen at rest or during exercise will not be an exclusion criterion.

Keywords: copd exercise self-management rehabilitation quality of life health economy cost effectiveness health care utilization
synera venipuncture pain

Conditions: Pain; Phlebotomy; Palliative Care

Summary: synera, which is a heated topical patch containing both lidocaine and tetracaine, is intended to reduce the pain associated with venipuncture and superficial dermatologic procedures by numbing the skin. this study will test the effectiveness of the synera lidocaine/tetracaine patch when administered for 30 ± 5 minutes to provide dermal anesthesia in adult oncology patients undergoing venipuncture as part of their care, for treatment or diagnostics (laboratory or imaging). compared to the use of the placebo patch, this study hypothesizes that the difference of 1 cm on the 0-10 visual analogue scale (vas) will be observed 30 minutes after the use of the synera patch. pain intensity will be assessed by a 0-10 vas


Eligibility criteria:
inclusion criteria: * patients with any tumor type where treatment is received through venipuncture or any procedure that is needle based or who require regular pharmacokinetic (pk) study. * is 18 years of age or older. * patients expected to undergo the first venipuncture procedure within 5 working days of enrollment. * male or female patients * has signed the most recent patient informed consent form * has signed a patient authorization form (hippa) exclusion criteria: * patients with sensitivity to lidocaine, tetracaine, or any other component of the product * known sensitivity to any components of test materials (sulphites and adhesives) * patients with damaged or broken skin at the designated patch site * pregnant or breastfeeding women patients * use of any immediate-release single-agent opioid product (ie, morphine, oxycodone, hydrocodone, hydromorphone, oxymorphone, or tramadol) or combination products containing acetaminophen or ibuprofen with one of these agents within 4 hours of the patient's visit * previous irradiation to the site of the patch

Keywords: pain control needle stick pain venipuncture pain
automatic evaluation of the anterior chamber angle width by a new non-contact optical device

Conditions: Glaucoma

Summary: the aim of the study is to evaluate an objective, non-invasive optical device able to quantify, without eye contact, the width of the irido-corneal angle and to better identify cases of narrow angle or angle closure that may be prevented with relatively simple treatments.

worldwide, glaucoma has been identified as a leading cause of blindness, second only to cataract. the two most common types of glaucoma are primary open-angle and angle closure glaucoma (pacg), both characterized by progressive and irreversible degeneration of the retinal ganglion cells and axons. in pacg, the optic neuropathy occurs as a consequence of raised intraocular pressure (iop) resulting from physical obstruction of aqueous outflow or degenerative changes in the trabecular meshwork. angle closure is the result of an anatomic characteristic that causes closure of the drainage angle by synechial or appositional approximation between the iris and the trabecular meshwork, blocking access to aqueous humor. although the most common mechanism responsible for angle closure is relative pupillary block, this is not the only one. angle crowding can be caused by plateaus iris, or by multiple mechanisms such as choroidal thickness and uveal expansion. a careful analysis of the anterior chamber angle is considered the main management strategy for pacg. the van herick grading of limbal anterior chamber depth is considered a screening tool for the estimation of angle width although gonioscopy remains the clinical reference standard for assessing the presence of narrow or closed angle. ultrasound biomicroscopy, scheimpflug imaging and anterior segment optical coherence tomography are considered as non-invasive alternatives to gonioscopy. however, these techniques are expensive and also have drawbacks. therefore, there is a need for an easy and objective method able to evaluate the angle width for screening purposes in clinical practice. based on these findings, the purpose of the present study is to evaluate an objective, non-invasive optical device able to quantify, without eye contact, the width of the irido-corneal angle and to better identify cases of narrow angle or angle closure that may be prevented with relatively simple treatments.

Eligibility criteria:
inclusion criteria: * willingness to participate and ability to understand and sign an informed consent. * 18 years of age or older. * healthy subjects, patients with pacs or angle closure as defined by the egs guidelines. * the right eye will be included in the study for all patients, unless a clinical contraindication to the examination is present. exclusion criteria: * inability to understand and sign an informed consent. * any prior ocular surgery or laser treatment with the potential to alter the natural anatomy of the anterior segment of the eye. * corneal or conjunctival abnormalities that preclude an adequate view of the anterior chamber.
assessing women's preferences for postpartum thromboprophylaxis: the prefer-postpartum study

Conditions: Venous Thromboembolism; Pregnancy Related

Summary: the preferences of pregnant women for postpartum thromboprophylaxis are largely unknown. the aims of this transversal study are to elicit the preferences of pregnant/postpartum women about postpartum thromboprophylaxis in semi-structured interviews, and to estimate the utility of the relevant health states (pulmonary embolism, deep vein thrombosis, postpartum hemorrhage, subcutaneous injections). in this second aim, the investigators will also compare the effect of 2 different techniques to estimate utilities (standard gamble vs. time trade-off), using a randomization of these techniques.


Eligibility criteria:
inclusion criteria: * women * ongoing pregnancy or within 7 days of delivery * fluency in french or english exclusion criteria: * fetal or neonatal death
knowledge evaluation and assessment of the effectiveness of an education intervention on acne

Conditions: Acne Vulgaris

Summary: acne vulgaris is a chronic inflammatory disorder of the skin in the pilosebaceous unit of the hair follicle, associated with oil production. it is found across skin types and is present in 85% of adolescents, representing a large affected population. because of the universal nature of the disease, 36.3% of acne patients come from backgrounds other than caucasian. the purpose of this study is to examine patient knowledge about acne in different populations and to assess the effectiveness of a teaching intervention on acne knowledge. the investigators aim is to better understand and subsequently reduce any potential health disparities within the minority populations. this project will evaluate differences in acne knowledge between different ethnic groups, and the efficacy of an educational intervention. subjects will first complete a survey evaluating their knowledge of acne and how acne affects them psychosocially before an educational intervention. immediately following the intervention, the patient's knowledge of acne will be evaluated again. finally, two months after the intervention, a phone call will be made evaluating their retention of the education materials and their quality of life related to psychosocial effects of acne. investigating this educational intervention and any current disparities in acne education and understanding will better allow us to educate and treat acne patients in the future.


Eligibility criteria:
inclusion criteria: * subjects ages 18 years of age and older and able to give consent * subjects with a diagnosis of acne vulgaris exclusion criteria: * subjects who are not proficient in english * subjects who were unable to give informed consent * subjects who do not have a diagnosis of acne vulgaris
influence of age, sepsis and slco1a2 polymorphisms on rocuronium pharmacokinetics

Conditions: Sepsis; Systemic Inflammatory Response Syndrome; Septic Shock

Summary: this study aims to evaluate the influence of age and sepsis on in vivo activity of oatp1a2 using rocuronium (roc) as a probe and evaluating the pharmacokinetics and pharmacodynamics in asa i-iii surgical patients. thus, adult patients without sepsis (control group, n= 12), adult patients with sepsis (sepsis group, n= 12) and elderly patients without sepsis (elderly group, n= 12), all submitted to small to medium-sized surgeries who were induced with individual doses of rocuronium, fentanyl and propofol are being investigated.

rocuronium (roc), a neuromuscular blocking agent used in surgical procedures, is primarily eliminated by biliary excretion. its distribution to the liver, mediated the organic anion transporting polypeptide 1a2 (oatp1a2), is a determining factor for the duration of neuromuscular blockade. age and release of cytokines during inflammation and infection processes of sepsis can alter expression of slco1a2 gene, encoding oatp1a2. the objective of this study is to evaluate the influence of age and sepsis on in vivo activity of oatp1a2 using roc as a probe and evaluating the pharmacokinetics and pharmacodynamics in asa i-iii surgical patients. adult patients without sepsis (control group, n=12), adult patients with sepsis (sepsis group, n=12) and elderly patients without sepsis (elderly group, n=12), all submitted to small to medium-sized surgeries are being investigated. all patients are being induced with individual doses of rocuronium, fentanyl and propofol. serial blood samples are being collected up to 360 minutes after administration of roc. neuromuscular blockade induced by roc is monitored by stimulation of the adductor muscle of the thumb on the ulnar nerve through the train of four monitoring (tof) at the same times of blood sampling. the plasma concentration of roc will be analyzed by liquid chromatography coupled to mass spectrometry with electrospray ionization using positive ion mode.

Eligibility criteria:
inclusion criteria: * adult and elderly patients, both gender. * patients submitted to small to medium-sized surgeries. * patients who were induced with individual doses of rocuronium, fentanyl and propofol. * patients with normal renal function (creatinine clearance \> 60 ml/min). * patients with normal liver function. exclusion criteria: * patients who were in use of fluoxetine, carbamazepine, aminoglycoside antibiotics, oatp1a2 inhibitors. * patients with gastrointestinal and liver diseases, neuromuscular disorders. * patients who were in chronic use of drugs which alter rocuronium effect.
application of hbv rapid tests as a tool for wide-use screening

Conditions: Hepatitis B; Liver Cirrhosis; Carcinoma, Hepatocellular

Summary: with over 280 000 chronic carriers, 2,500 new annual cases and 1,300 deaths each year, hepatitis b is currently a frequent and potentially severe disease in france, despite efforts towards prevention and effective care. in terms of prevention, france has very low immunization coverage (27.7%) and a high percentage of people ignoring hbv status (55%), leading to a delay in care. this is partly explained by poor knowledge of hepatitis b infection in the general population and an underestimation of the health impact of hepatitis b by doctors and health officials. until recently, there have been no national guidelines governing its implementation (which is variable depending on the structures where screening is performed) and an insufficient evaluation of screening practices. thus, data on the severity of liver disease, indications for treatment of hbv-infected patients and data on the use of vaccination for nonimmunized people are scarce. furthermore, while hiv rapid tests are beginning to be used more widely, particularly to address the issue of people who do not come back and collect their results and to better adapt "counselling", their usefulness to detect of hepatitis b virus has not been evaluated to date. the main objective of the optiscreen b study is to determine the benefit, if any, of using rapid tests as a screening tool to improve diagnosis, care and prevention of hepatitis b. individuals risk of hbv-infection will be randomized into 2 groups, one group for which screening will be performed by usual serological test and a second group for which screening will be based on rapid tests. centers will be selected to represent a diverse range of health centers whose aims include screening, prevention and/or vaccination.


Eligibility criteria:
inclusion criteria: * born in a country of middle or high hbv endemicity * parents born in a country of middle or high hbv endemicity * travellers or residents from a country of middle or high hbv endemicity * blood, organ, tissue, sperm, and/or ovary donners or candidate donners. * health-care workers suspected of coming into direct contact with an hbv-infected individual and/or exposed to blood or any biological products from an hbv-infected individual * close contact with hbsag-positive individuals (living in the same household, sexual partner, sharing needles, etc.) * individuals with accidental exposure to hbv * individuals with multiple sexual partners * men who have sex with men * pregnant women * hemodialysis * individuals requiring immunosuppressive therapy * individuals with persistently elevated transaminase levels * hiv-positive * intravenous drug users exclusion criteria: * age \<18 years old * not capable of providing informed consent * already participated in a multi-center validation of hbv rapid tests * having, in their possession, irrefutable results of a prior test for hepatitis b virus

Keywords: rapid test screening elisa hepatitis b virus access to care
mesenchymal stem cells transplantation for ischemic-type biliary lesions

Conditions: Ischemic-type Biliary Lesions

Summary: ischemic-type biliary lesions (itbls) are a major cause of graft loss and mortality after orthotopic liver transplantation (olt). for now, there are still lacking effective treatment for itbls. the purpose of this study is to confirm whether human umbilical cord mesenchymal stem cells are effective in the treatment,or prevention of ischemic-type biliary lesions after liver transplantation.

advances in organ preservation techniques, immunosuppressive regimens, and surgical techniques have resulted in reduced rates of infection, acute rejection and vascular complications after orthotopic liver transplantation (olt). however, ischemic-type biliary lesions (itbls) are still one of the most serious complications after olt, with a usual reported incidence of 5-15%, and an incidence of up to 26% in some studies. 46% patients with itbls require re-transplantation after 2 years of olt. mesenchymal stem cells (mscs),a kind of pluripotent stem cells,can differentiate into vascular endothelial cells, which participate in angiogenesis in ischemic tissue. mscs can also stimulate the proliferation and migration of mature endothelial cells via paracrine.furthermore, mscs secret a variety of cytokines and growth factors, such as vascular endothelial growth factor, human basic fibroblast growth factor, hepatocyte growth factor, interleukin-1 and interleukin-8, etc., which also induce angiogenesis. participants in the study will be randomly assigned to one of two treatment arms: * arm a: participants will receive 6 months of standard regular treatment for itbls plus huc-mscs treatment. * arm b: participants will receive 6 months of standard regular treatment for itbls plus placebo. huc-mscs will be prepared according to standard procedures and is collected in plastic bags containing anti coagulant. mscs are given via i.v. after huc-mscs transfusion, patients are followed up once per week(in the first months,\<1m),once per 2 week(1-3m)and once per month(3-6m), and the evaluation of liver function and biliary blood supply was performed.

Eligibility criteria:
inclusion criteria: * benign end-stage liver disease patients with liver transplantation. * ages of 18 and 60 years. * first liver transplant. * gamma-glutamyltransferase \> 300 u/l for 2 weeks, and there was no or low enhancement of the wall of the hilar bile duct in arterial phase via contrast-enhanced ultrasonography. * written informed consent. exclusion criteria: * second or combined organ transplant recipient. * vital organs failure (cardiac, renal or respiratory, et al). * clinically active bacterial, fungal, viral or parasitic infection. * other candidates who are judged to be not applicable to this study by investigators.

Keywords: liver transplantation biliary complication mesenchymal stem cells
nanofat in post burn scars on the face

Conditions: Burn Scar

Summary: quasi-experimental study: unfiltered nanofat injected into postburn facial scars number of patients: 48 outcome assessed on posas and with imaje j scanning preop and postop statistical comparison of scar done

objective: to compare the quality of post burn facial scars before and after injection of unfiltered nanofat. place and duration of study: plastic surgery department, mayo hospital, lahore, from january 2016 to december 2016. methodology: 48 patients with post burn facial scars were included, age range 4 to 32 years with fitzpatrick skin types between 3 and 4. patients with hypertrophic scars, contractures or keloids were excluded. scars were assessed by a senior plastic surgeon and the patient on the posas. fat was harvested from the abdomen and/or thighs with a 3 mm multi-port liposuction cannula (containing several sharp side holes of 1 mm) using coleman's technique, emulsified, and transferred into 1 ml leur lock syringes for injection into the subdermal or intradermal plane. final follow up was scheduled at 6 months and scar was rated by the patient and the same surgeon on the posas. pre and post op scar scores were compared and p-values calculated.

Eligibility criteria:
inclusion criteria: * post burn scars on the face * fitzpatrick skin types between 3 and 4 exclusion criteria: * hypertrophic scars * contractures * keloids

Keywords: post burn scar face unfiltered nanofat adipose tissue growth factors adipose stem cells posas image j face