Kornimate/medical-research-clean huggingface dataset:
heterotopic ossification in abdominal incision and pancreatic cancer

Conditions: Cancer of Pancreas; Ossification, Heterotopic

Summary: to investigate whether pancreatic cancer is the cause of heterotopic ossification of abdominal incision.

heterotopic ossification of abdominal incision (hoai) has long been regarded as a rare complication after general surgery. however,according to our retrospective analysis. hoai was more frequently observed in the malignancy group (33/121 cases, 27.3%) than in the non- malignancy group. because of the many biases in the retrospective analysis, the result was not widely shared. the purpose of this prospective study is to confirm that pancreatic cancer is the cause of heterotopic ossification of abdominal incisions. according to postoperative pathology, the patients were divided into two groups: pancreatic cancer group and benign diseases group.the researchers will observe whether patients develop heterotopic ossification of the abdominal incision one year after surgery to conclude.

Eligibility criteria:
inclusion criteria: * obtain informed consent from the patients. * the patient's abdominal incision was double-closed with continuous suture of linea alba and fascia with absorbable suture, and skin was sutured with skin staples. exclusion criteria: * refusing to join the study * previous history of malignant tumor * previous history of midabdominal incision * abnormal calcium and phosphorus metabolism * distant metastasis * palliative operation * performing neoadjuvant chemotherapy

Keywords: cancer of pancreas ossification, heterotopic abdominal incision
tracking intervention effects with eye tracking

Conditions: Autism Spectrum Disorder

Summary: this pilot study examines concurrent and predictive relationships between eye tracking and clinical outcomes during a 16-week behavioral intervention (prt) for children with asd. eye tracking will be comprised of both laboratory-based measures (using a commercial eye-tracking system) as well as home-based measures (using tablet-based eye tracking systems). the major goals of this study are both to improve our understanding of the potential role of eye tracking in clinical trials and to advance technologies that may further improve the sensitivity, robustness, accessibility, and ultimate utility of eye tracking methodologies.


Eligibility criteria:
inclusion criteria: * individuals ages 4-7 years diagnosed previously with asd and meet criteria for asd when characterized by our research team, english is a language spoken in the family, and full-scale iq\>50. participants must also complete laboratory and home-based eye tracking sessions, with success determined by the principal investigator. exclusion criteria: * individuals will be excluded from participation based on the presence of 1. a physical or neurological disorder (e.g., cerebral palsy) which is likely to impact development and learning, as intervention procedures for these individuals may need to be modified beyond the standard approach to address more complex developmental needs, 2. hearing loss or other severe sensory impairment, 3. history of significant head trauma or serious brain or psychiatric illness, 4. parents/caregivers who do not speak fluent english, 5. parents/caregivers who have previous training in prt 6. individuals who must be excluded from eye tracking. these families will be offered the treatment clinically (i.e., fee-based), and they will be given referrals to outside agencies offering the treatment as well.
improving lifejacket wear among boaters on lake albert, uganda

Conditions: Drowning

Summary: a cluster randomized trial will be conducted for six months. to avoid covariate imbalance at baseline, stratified permuted block randomization with a 1:1 allocation ratio will be done. at least 387 boaters across 7 clusters per arm will be interviewed post baseline to give a 90% power to detect the effect of the intervention if such effect exists. a mixed effects multi-level modeling at 5% alpha level will be done using logical model building procedures

given that the intervention will be at the community level, a cluster randomized controlled trial is considered most appropriate for testing the hypothesis of this study. the intact groups/clusters of individuals (boaters) rather than individuals themselves, will be randomized to either intervention or control arm. the landing sites herein referred to as clusters, will be the randomization unit. this is because it is difficult to randomize individuals to behavioral intervention since they mix within the cluster. this study will be conducted using an etic epistemological approach guided by a realist ontology in order to objectively measure the effect of the intervention without the influence of the researchers. to reduce covariate imbalance and increase comparability at baseline, clusters will be randomized to either intervention or control arm using stratified permuted block randomization, with landing sites (clusters) as the randomization unit. the clusters will be stratified by estimated population size and baseline prevalence of lifejacket use as compared with the overall average prevalence. all individuals in the intervention cluster will receive the intervention. the main aim of the stratified randomization is to ensure that the clusters are as comparable as possible at baseline. the other factors that might be considered for stratification will be identified at baseline and, in the opinion of the investigator, might interfere with the objectives of the study. because there are few clusters per arm (7), two strata will be formed. the stratification variable will be the baseline prevalence of lifejacket wear in the landing sites. the risk of contamination (one of the major threats to this study) will be reduced by ensuring that at least one cluster which is not part of the study acts as a buffer. from each stratum, one cluster will be randomly allocated to the intervention arm and the other to the control arm using stratified permuted block randomization with a 1:1 allocation ratio. the allocation will be generated using the 'sealed envelope tm' web-based application by an independent statistician who has no interest in the study. the block sizes will be masked/blinded to increase the randomness.

Eligibility criteria:
inclusion criteria: * the landing sites (clusters) should not be flooded, should not be receiving any known educational/behavior related intervention except the routine marine police messages exclusion criteria: * landing sites that are inaccessible because of the bad terrain and poor security

Keywords: drowning prevention occupational boating uganda
an investigational study of continuous 8-hour intravenous administrations of bms-986231 in participants with heart failure and reduced heart function given a standard dose of loop diuretic

Conditions: Cardiac Failure; Myocardial Failure; Congestive Heart Failure; Heart Decompensation

Summary: the purpose of this study is to investigate continuous 8-hour introductions of bms-986231 in participants with heart failure and weakened heart function given a standard dose of diuretic.


Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * left ventricular ejection fraction \<45%, as assessed by echocardiography, a multigated acquisition (muga) scan or magnetic resonance imaging (mri) scan within 18 months * on stable chronic guideline-directed therapy for hf including chronic loop diuretics, acei, arbs, mras, arni or / and β-blockers as tolerated, with no changes of these medications in the past 2 weeks * at least an oral dose of 40 mg of furosemide/day or equivalent (20 mg torsemide, 1 mg bumetamide) exclusion criteria: * sbp \ 180 mm hg at screening or pre-randomization * heart rate \ 120 bpm at screening or pre-randomization * primary hf etiology attributable to either restrictive/obstructive cardiomyopathy, idiopathic hypertrophic or uncorrected severe valvular disease other protocol defined inclusion/exclusion criteria could apply
women empowered to live with lupus study

Conditions: Lupus Erythematosus, Systemic

Summary: the purpose of this research is to examine whether the chronic disease self-management program (cdsmp) would improve health outcomes and reduce health care use in african american women with systemic lupus erythematosus (sle). the cdsmp is a generic, evidence-based self-management education program that has been shown to help people with chronic conditions to take control of their health problems. this study focuses on african american women with sle because the cdsmp has not been widely studied in this population.

the cdsmp is an evidence-based, community-based, generic self-management program that consists of 6 weekly classes of two and a half hours each one, for six weeks. cdsmp classes are facilitated by certified peer leaders. because the cdsmp is widely disseminated and available to the adult u.s. population through community centers, it may be a suitable and accessible option for african americans with sle, even though it is not specifically tailored to sle or to african americans. as the cdsmp has been primarily evaluated in predominantly white middle-class seniors with more common diseases (e.g. osteoarthritis, diabetes), the effectiveness of the cdsmp in helping african american women to self-manage sle is unknown. this study will examine the effectiveness of the cdsmp to improve patient-reported outcomes and reduce health care utilization in african american women with lupus. using a two-group longitudinal cohort design with participants sampled from a parent population-based sle cohort in georgia, investigators will examine behaviors, health and healthcare outcomes, and the extent to which individual characteristics modify the effectiveness of the cdsmp. the georgians organized against lupus (goal), a longitudinal cohort of patients with a validated diagnosis of sle, will be used to enroll participants into the intervention. a random sample of african american women with sle selected from the parent goal cohort will be recruited into the well (women empowered to live with lupus) cohort. well participants will attend the cdsmp classes in the community, along with people with other chronic illnesses. well participants will be asked to attend the cdsmp in the community and answer questionnaires at 4 select time periods before and after the program. investigators will follow participant's progress for up to 18 months after they attend the cdsmp. african american women from the goal cohort non-selected to be assigned to the intervention will comprise the usual care group. participants will continue their longitudinal assessments as part of the goal cohort data collection efforts. changes in outcomes for up to 18 months will be compared between well participants and the usual care group.

Eligibility criteria:
inclusion criteria: * currently participating in the goal study exclusion criteria: * participation in the chronic disease self-management program (cdsmp) in the past five years * significant cognitive impairment

Keywords: autoimmunity immune system disorders
study on discopathie with modic 1

Conditions: Lumbar Hernia

Summary: the chronic lumbago can be associated with an active discopathie, objectified on the mri by the presence of an inflammatory signal (modic 1) or greasy (modic 2) vertebral trays framing the pathological vertebral disk the treatment recommended by t consists in particular of a local infiltration of corticoids which the efficiency is variable according to the patients. the objective of this study is to estimate the efficiency of the local treatment and to highlight some of the factors associated to the advantage of the infiltration by corticoids.


Eligibility criteria:
inclusion criteria: * patient admitted in rhumatology service for intra-disc infiltration * chronic pain (\>3 monts) * vas \>3 * mri stipulating modic 1 exclusion criteria: * radiculalgy * radicular vas\< lumbar vas * pregnancy * local infection * corticoid allergy * previous rachial surgery * previous spondylodiscite * psychiatric disorder * mri contraindication
efficacy study of a new eyedrop on silicone hydrogel contact lens wearers with dry eye complaints

Conditions: Contact Lens Related Dry Eye Syndrome

Summary: the objectives of the investigation will be to assess the effect of the repeated usage of a new eye drop on the tear film characteristics of silicone hydrogel contact lens wearers with contact lens related comfort problems and to quantify any potential benefit.


Eligibility criteria:
inclusion criteria: * current silicone hydrogel contact lens wearer * complaints of contact lens related dry eye (symptoms and reduced comfortable wearing time) exclusion criteria: * known allergy or sensitivity to the study product(s) or its components * systemic or ocular allergies * use of systemic medication which might have ocular side effects. * any ocular infection. * use of ocular medication. * significant ocular tissue anomaly
penumbra imaging collaborative study (pics)

Conditions: Stroke

Summary: the primary aim of this study are to gather data on the "real world" experience of the penumbra system and to determine if there is a correlate between the imaging-defined size of the ischemic penumbra at admission and patient outcome in patients already treated by the system. this will be accomplished by the collection of all available admission imaging data along with patient clinical and functional outcome results at 90-day follow-up to determine if a positive association exists between these variables. a secondary aim is to collect and summarize the 90-day functional outcome data for the purpose of sample size estimation for a potential randomized concurrent controlled trial. this will be accomplished by collecting the data on 90-day modified rankin scores (mrs) and all cause mortality.


Eligibility criteria:
inclusion criteria: * all patients who signed informed consent and revascularized by the penumbra™ system in accordance to the instruction for use are eligible for this study.

Keywords: penumbra system mechanical thrombectomy ischemic stroke intervention neurovascular thrombus imaging ischemic penumbra functional outcome
determinants of respiratory health in young adults

Conditions: Lung Diseases

Summary: to measure lung function and respiratory symptom status in a large cohort of healthy, non-smoking 18-22 year old subjects, and relate these measurements to past histories of passive smoke and air pollution exposures.

background: while the natural history of human lung function growth and decline has been studied intensively over the past 30 years, relatively few data have been collected during the period in which peak volumetric function is achieved, i.e., around the age of 20. as a result, very little is known about the factors, both demographic and environmental, which influence maximal attained lung function. design narrative: the longitudinal study collected information on the history of respiratory illness, residential history, parental smoking, socio-economic status and home characteristics via an initial questionnaire administered to cadets enrolling at west point. a sequence of four annual measurements of lung function (by spirometry), and prior-year respiratory health status and activity patterns was obtained in the spring of each year. pollution exposures were estimated by matching residential histories with historical pollution data stored at the environmental protection agency. data on meteorological variables (temperature, relative humidity, wind speed) and altitude were obtained for each residential location. the four annual lung function measurements provided precise estimates of individual mean levels of fvc, fev1, fef25-75, pefr, and flow rates at 50 percent and 75 percent of expired fvc. subject-specific lung function level was analyzed in relation to history of parental smoking and prior exposure to air pollution using analysis of variance methods, controlling for potential confounding variables. in addition to testing these hypotheses regarding the respiratory effects of passive smoking and air pollution exposure, the study also explored the effects of these exposures on the change in lung function between the ages of 18 and 22 and on respiratory illness and symptom experience while at west point. finally, the study established a cohort which could be followed in future years. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
safety and efficacy of intravenous tranexamic acid in endoscopic transurethral resections in urology

Conditions: Hemorrhage

Summary: transurethral resection of the prostate (turp) represents the gold standard in the operative management of benign prostatic hyperplasia (bph) and the transurethral resection of bladder tumor (turbt) is the first-line surgical treatment for bladder tumors. one of the most important complications of urological endoscopic resections is intraoperative and postoperative bleeding requiring blood transfusion. allogeneic blood transfusion is not free of risks, like infection transmission, hemolytic reactions, transfusion-related lung injury, fluid overload, increased costs and hospital length of stay. tranexamic acid (txa) is a synthetic analog of serin than reversibly inhibits fibrinolysis by blocking lysine union sites in the plasmin and plasminogen activator molecules. txa has been used to reduce blood loss and the need for allogeneic blood transfusion in cardiac surgery and orthopedic surgical procedures but few studies have assessed the efficacy of this antifibrinolytic agent in urological endoscopic procedures. the investigators designed this double-blind, placebo controlled study evaluate the safety and efficacy of the antifibrinolytic agent tranexamic acid in reducing blood transfusion in patients undergoing endoscopic surgery in urology.

participants will be randomized into one of two study groups: group txa: intravenous tranexamic acid: bolus of 10 mg/kg thirty minutes before resection followed by infusion of 1 mg/kg/h intraoperatively and for 24 h postoperatively. control group c: an equal volume of saline. the study drug was prepared by an anesthesiologist not involved in the patient management and data collection. the anesthetic technique will be standardized. serum hemoglobin was measured before and after surgery. the volume of the irrigation fluid, resected prostate weight and duration of resection were recorded.

Eligibility criteria:
inclusion criteria: 1. adult (\>/=18) 2. male or female 3. undergoing elective turp or turbt 4. spinal anesthesia 5. subject is american society of anesthesiologists (asa) physical status 1 or 2. exclusion criteria: 1. atrial fibrillation 2. coronary artery disease treated with drug eluting stent 3. severe chronic renal failure 4. congenital or acquired thrombophilia 5. known or suspected allergy to tranexamic acid.

Keywords: tranexamic acid transurethral resection of the prostate (turp) transurethral resection of a bladder tumor (turbt) hemorrhage blood transfusion
underwater endoscopic mucosal resection

Conditions: Colon Polyp; Adenoma Colon

Summary: the global aim of this multi-centric study is to assess the learning curve of u-emr by an endoscopist skilled in c-emr aiming to assess the application in real world and check the rate of complete emr and adverse events related to the procedure.

conventional endoscopic mucosal resection (c-emr) is currently the standard therapy for the removal of large colon polyps. the procedure consists on the injection of fluids into the submucosa layer below the lesion with the intention to create a cushion to separate it from the muscular layer and avoid its damage and consequently perforation and thermal injury. there are some drawbacks about this technique such us fibrotic polyps, difficult location (areas behind the fold and appendicular orifice) and recurrence rate which without ablation techniques could reach 30%. underwater endoscopic mucosal resection (u-emr) has been first described in 2012 by binmoeller et al \[10\] and the main difference to c-emr was the absence of need the submucosal injection. this would be possible because when the lumen is filled with water, the mucosal and the submucosal layer tend to float while the muscularis propria maintains its circular shape even in the presence of peristalsis. recent data as shown not only a lower rate of recurrence but also a lower procedure time and r0 resections with no difference in adverse events. therefore, the global aim of this multi-centric study is to assess the learning curve of u-emr by an endoscopist skilled in c-emr aiming to assess the application in real world and check the rate of complete emr and adverse events related to the procedure.

Eligibility criteria:
inclusion criteria: * age: 18 years-old or older with at least one large (\>10 and \<30 mm) non pedunculated polyp * agreement with study's procedures, having signed the informed consent for the study and emr, prior to the procedure exclusion criteria: * previous attempted resection * lesion located at ileo-cecal valve or appendiceal orifice * fully circumferential lesion * pedunculated polyps (paris classification type ip) and ulcerated depression lesions (paris classification type iii) * surface pattern suggestive of deep invasion (ex: narrow-band imaging (nbi) international colorectal endoscopic (nice) classification type 3 criteria, kudo v or equivalent) * invasive cancer at emr specimen * inflammatory bowel disease * familial polyposis syndrome
corticalisation after femoral nail dynamization in hypertrophic non-unions

Conditions: Pseudoarthrosis of Bone; Implant Breakage

Summary: in 12 patients with corticalization and hypertrophic pseudarthrosis were present after dynamization, the old nail was removed and nail exchange was performed with a longer and larger diameter nail to pass the region formed in the cortex approximately 2-3cm inferior from the old nail.

corticalization is cortex-like sclerosis in the distal of the nail and it may indicate the early sign of dynamization treatment failure in hypertrophic nonunion after femoral transverse diaphyseal fractures. when corticalization is seen during follow-up after dynamization is performed because of non-union of a femoral transverse fracture, nail exchange should be performed without further delay. more rigid fixation should be applied with a longer and thicker nail crossing the area of corticalization.

Eligibility criteria:
inclusion criteria: * subtrochanteric fractures * nonunion with pain exclusion criteria: * infection * pathological fracture (tumor)

Keywords: hypertrophic pseudarthrosis dynamization corticalisation