Kornimate/medical-research-clean huggingface dataset:
detection of eating disorders in pregnant women

Conditions: Eating Disorders; Pregnancy Related

Summary: eating disorders (ed) are insufficiently detected and belatedly or not treated during pregnancy. there are many screening questionnaires for eating disorders in the literature, but we note the absence of a specific and validated tool for their screening during pregnancy, which would make it possible to differentiate maternal dietary concerns related to pregnancy from symptoms linked to a proven eating disorder. the main objective of the study is to evaluate which items of the sick control one stone fat food (scoff-f) and eating disorders examination questionnaire (ede-q) questionnaires could be specific to an ed during pregnancy and not related to the simple state of pregnancy, by comparing the answers of pregnant women, for whom the diagnosis of ed has been made, to those of pregnant women without an ed.


Eligibility criteria:
inclusion criteria: * adult pregnant woman * woman with current diagnosed eating disorders or without eating disorders * having a good command of the french language * having given their consent for their participation in the research exclusion criteria: * underage pregnant woman * woman who does not have a good command of the french language. * woman with past eating disorders
tdcs stimulation to treat patients with severe and resistant obsessive compulsive disorder-pilot study

Conditions: Obsessive-compulsive Disorders and Symptoms

Summary: the purpose is to show that bifocal tdcs with an anodal stimulation on the orbitofrontal cortex and cathodic stimulation on supplementary motor areas is an effective treatment for patients with resistant and severe obsessive compulsive disorders.


Eligibility criteria:
patients must present all of the following criteria in order to be eligible: inclusion criteria: * meets criteria for obsessive compulsive disorder according to dsm-iv with a "good insight" (babs), * age: participants will be both males and females, 18-70 years of age included. * no current depressive and suicidal risks, * no epileptic pathology, * chronic evolution ( total y-bocs\>20 ), * obsessive compulsive disorder resistant to pharmacology treatment, at least 2 antidepressants (type irs) or cognitive and comportment therapy since at least one year, * stability treatment (antidepressants) for more than 12 weeks without significant improvement, * affiliation to a social security system (recipient or assignee), * signed written inform consent form. exclusion criteria: * female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing, * patient under curators * meets another diagnosis of axe 1 of dsm-iv, * current depressive or suicidal risks, * patient with a benzodiazepine treatment, * patient with any form of metal in the cranium, a pacemaker, skull defects, or skin lesions to the scalp (cuts, abrasions, rash) , * epileptic patient, * patient with a medical history of cranial trauma, * patient unable to give his or hers informed consent.

Keywords: transcranial direct current stimulation supplementary motor area orbitofrontal cortex
clinical study of qsox1 as a biomarker for colon cancer

Conditions: Colon Cancer

Summary: the goal of this observational study is to determine whether the secreted protein qsox1 can be used as a molecular marker for early rapid diagnosis and accurate treatment of colon cancer.

the project mainly selects the tumor group represented by colon cancer and the corresponding healthy people as the control group, with about 100 cases in each of the two groups. mainly collect blood and tumor tissue samples of patients, detect the expression of qsox1 in the above samples, and explore the role in the diagnosis and prognosis evaluation of colon cancer.

Eligibility criteria:
inclusion criteria: * colon cancer was confirmed by colonoscopic pathology. * no local or systemic treatment was performed before operation. * complete clinical data. exclusion criteria: * combined with benign diseases of colon, such as ulcerative colitis, colon adenoma and colon polyp. * other tumors other than colon cancer.
retinal vessel leakage in cerebral small vessel disease

Conditions: Cerebral Small Vessel Diseases; Lacunar Stroke; Vascular Dementia

Summary: the goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. the main questions it aims to answer are: * does retinal vessel leakage occur in cerebral small vessel disease? * if it does, is the severity of retinal vessel leakage similar to the severity of cerebral small vessel disease generally? participants will be tested using fluorescein angiography. this involves an intravenous injection of fluorescent dye, and is a very sensitive way to find leakage from retinal blood vessels. participants will have already had brain scans and other examinations and tests to measure the severity of their cerebral small vessel disease. our new retinal images will complement the information from these previous tests.

cerebral small vessel disease (svd) is a common cause of stroke and dementia. the molecular causes are unclear, limiting new therapies. breakdown of the blood-brain barrier (bbb) is characteristic and may damage brain tissue. however, specialist mri scans to measure bbb breakdown are expensive and time-consuming. in contrast, measuring leakage from retinal blood vessels is relatively simple. the blood-retina barrier is very similar to the bbb, and svd is likely to damage retinal and brain blood vessels in the same way. if so, then retinal angiography could be used to study svd pathogenesis and measure the effect of new treatments with much greater resolution and lower cost than mri. we have three aims: 1. test the feasibility of fluorescein angiography in people with svd 2. discover if retinal vessel leakage occurs people with svd 3. discover whether the severity of retinal vessel leakage is associated with clinical features of svd we will recruit participants from a well-established cohort of people with svd - the mild stroke study 3 (mss3).

Eligibility criteria:
inclusion criteria: * membership in the mild stroke study 3 cohort * contrast enhanced mri within 12 months * clear optical media in both eyes, as assessed by study investigator * best corrected visual acuity (near vision) ≥n36 exclusion criteria: * any condition known to cause retinal leakage (i.e., worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, malignant hypertension) * previous treatment for retinal leakage (retinal laser, intravitreal anti-vegf) * recent eye surgery * shallow anterior chambers as assessed by torch test * pregnancy, renal failure * severe dementia * known allergy to fluorescein * history of allergy such as food or drug induced urticaria or history of bronchial asthma * any other severe or acute medical or psychiatric conditions * inability to give informed consent
study evaluating safety of ragweed mix given by intralymphatic node injections

Conditions: Allergic Conjunctivitis; Allergic Rhinitis

Summary: a safety study conducted on subjects ≥16 years old evaluating the safety of 4 intralymphatic injections of 2 different dose levels of the investigational short and tall ragweed product. biomarkers will be assessed at baseline and at multiple time points post-treatment.


Eligibility criteria:
inclusion criteria: * between the ages of 16 and 65 years old * seasonal allergic conjunctivitis (with or without allergic rhinitis) to ragweed pollen * positive skin test reaction at screening visit to short ragweed extract * avoid disallowed medications * females of childbearing potential must have pregnancy test and must agree to use an acceptable method of birth control * have blood and urine analysis within normal limits * manifest a positive reaction to a conjunctival allergen challenge with ragweed pollen * have a specific ige ≥ 0.70 ku/l to short ragweed exclusion criteria: * have ocular or nasal conditions that could affect subject safety or trial parameters * have a presence of an active sinus, nasal, or ocular infections * have had allergy immunotherapy to ragweed pollen * have a compromised lung function ≤80% of predicted
low-load blood flow restriction training in copd

Conditions: COPD; Muscle Weakness

Summary: peripheral muscle weakness is a predominant problem in patients with copd and treated using exercise training in pulmonary rehabilitation. despite pulmonary rehabilitation being an effective intervention, muscle strength impairment is a persisting problem in copd patients. patients have problems to tolerate the high training loads, which are necessary to develop strength. low-load blood flow restriction training (ll-bfrt) might therefore be an option to enhance muscular response of patients with copd to strength training. up to now, no studies investigating ll-bfrt in respiratory diseases are available. the primary outcome of this randomized pilot study is knee extensor muscle strength. secondary, the study will evaluate if ll-bfrt is well tolerated and feasible in copd patients attending outpatient pulmonary rehabilitation.


Eligibility criteria:
inclusion criteria: * diagnosed copd according to gold-guidelines * assigned to outpatient pulmonary rehabilitation by the treating physician exclusion criteria: * physical or intellectual impairment precluding informed consent or protocol adherence * non-german speaking (precluding informed consent) * acute or recent (within the last 6 weeks) exacerbation of copd * attending a pulmonary rehabilitation program within the last 3 months * pregnant patients * history of thromboembolic event in the lower extremity * diagnosis of polyneuropathy * resting systolic blood pressure \<100 mmhg

Keywords: blood flow restriction training pulmonary rehabilitation copd muscle weakness
apa and pas training for gait initiation in parkinson's disease

Conditions: Parkinson Disease

Summary: our research focused on understanding the interplay between brain excitability and balance function in patients with parkinson's disease (pd), alongside evaluating effective physical therapy methods. it highlights the prevalence of non-motor disorders and cognitive impairments among pd patients, including balance and postural issues, cognitive function decline, and gait instability. additionally, it notes that pd patients exhibit abnormal electrophysiological responses, indicating altered central excitability.

research on brain excitability and balance function performance in patients with parkinson's disease and related physical therapy methods research indicates that non-motor disorders and cognitive impairments are prevalent in most patients with parkinson's disease. these include balance issues, postural instability, impaired cognitive functions like working memory and executive functions, and gait instability. additionally, electrophysiological phenomena in parkinson's disease patients reveal abnormal central excitatory and inhibitory responses compared to healthy individuals. this experiment seeks to investigate the link between motor performance and brain excitability in patients with parkinson's disease. previous studies suggest that associative electrical stimulation, used to regulate sensorimotor information integration, can enhance brain excitability in both healthy individuals and those with parkinson's disease. however, the optimal parameters for this stimulation remain uncertain. furthermore, balance exercise training can improve motor performance in parkinson's disease patients. this study aims to determine if various designs of associative electrical stimulation parameters can help these patients achieve optimal brain excitability regulation. the combined approach of this stimulation and balance exercise training aims to maintain and improve the patients' functional performance, thereby enhancing the safety of their daily activities.

Eligibility criteria:
health subjects: exclusion criteria: * musculoskeletal injuries on legs. * osteoporosis. pd subjects: inclusion criteria: - clinical diagnosis of parkinson disease. exclusion criteria: * musculoskeletal injuries on legs * osteoporosis. * any peripheral or central nervous system injury or disease patients.

Keywords: gait initiation balance training anticipatory postural adjustments paired associative stimulation (pas) transcranial magnetic stimulation (tms)
distance and hybrid learning for dental student during covid-19 pandemic

Conditions: Education

Summary: to assess dental student opinion about distance educational learning environment during covid-19 pandemic and to assess their satisfaction with hybrid learning

coronavirus crisis has caused disturbance in the provision of education all over the world. in egypt institutions of higher education has taken the decision to temporarily suspend attendance in universities and to keep it closed for student during this pandemic. cairo university overcome this problem by avoiding gathering and facilitating the continuity of education for all through remote learning. in faculty of dentistry cairo university, pediatric dentistry course coordinators and instructors made modifications in their course which is taught to 5th year dental student. these modification included continuation of lectures and group sections through distance learning, while postponing any clinical work to avoid direct contact with patient. in the next academic year the same course was taught in different way through hybrid learning so the aim of the study was to compare education learning environment experiences among 5th year dental students enrolled in pediatric dentistry course through hybrid learning versus distance learning and to assess students satisfaction with hybrid learning , which will spot the light on strong and weak points in order to provide better education and improve their experiences.

Eligibility criteria:
inclusion criteria: * all 5th year dental student enrolled in pediatric dentistry hybrid and distance course in cairo university was invited to participate exclusion criteria: * incomplete questionnaire

Keywords: hybrid learning distance learning learning autonomy
the effect of surgical incision size on carpal tunnel surgery

Conditions: Carpal Tunnel Syndrome

Summary: this study will investigate the postoperative recovery advantages from having a smaller incision to a larger incision.


Eligibility criteria:
inclusion criteria: * patients undergoing open carpal tunnel release will be included in this study. * patients must have clinical evidence of carpal tunnel syndrome * patients must have positive emg results patient selection factors include: 1. ability and willingness to follow instructions 2. patients who are able and willing to return for follow-up evaluations. 3. patients of all races and genders. 4. patients who are able to follow care instructions. exclusion criteria: * patients less than 18 years old * patients unwillingly or unable to comply with a rehabilitation program for carpal tunnel release who indicate difficulty or inability to return for follow-up visits prescribed by the study protocol. * patients who qualify for inclusion in the study, but refuse consent to participate in the study.
a clinical study of light therapy on depressive episodes of bipolar disorder

Conditions: Depressive Episodes of Bipolar Disorder

Summary: the purpose of this study is to investigate the efficacy and safety of light-emitting diode(led) light therapy on chinese patients with depressive episodes of bipolar disorder and to gather prime research data and application parameters of led light source which is not currently available in china.


Eligibility criteria:
inclusion criteria: * ages 18 to 65 years * comply with the dsm-iv diagnosis of bipolar i or ii disorder and a current depressive episode * hamd score ≥17 points * intake of just one particular psychotropic drug(a mood stabilizer or an atypical antipsychotic drug) except of antidepressants and lasted 2 weeks. exclusion criteria: * inability to provide informed consent; * previous treatment with blt * presence of another major psychiatric illness such as schizophrenia, schizoaffective disorder, lifetime alcohol or substance dependence * diagnosed with a rapid-cycling bipolar disorder or currently in the mixed state or ymrs score\>12 points * use of antidepressants medications * significant medical illness such as diabetes mellitus,heart failure, renal failure, severe liver function abnormalities,hyperthyroidism or hypothyroidism * pregnancy; * received magnified electroconvulsive therapy orrepetitive transcranial magnetic stimulation in the past 3 months * an eye condition that could be negatively affected by bright light * suicidal risk or other factor making trial participation clinically inappropriate.
oral ketone monoester supplementation and resting-state brain connectivity

Conditions: Cerebrovascular Function; Cognition

Summary: people who report subjective memory complaints have a greater risk of developing dementia. memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow. interventions that can restore cerebral metabolism and enhance cerebral blood flow may protect against conversion to dementia. exogenous ketone supplements have been shown rapidly improves brain network function in young adults. further, infusion studies demonstrate that ketone bodies enhance cerebral blood flow in cognitively normal adults. whether acute ketone monoester supplementation can improve brain function in adults with subjective memory complaints is currently unknown. this study will investigate the effects of a single ketone monoester dose on resting-state functional connectivity in the default mode network and resting cerebral blood flow in adults with subjective memory complaints.


Eligibility criteria:
inclusion criteria: * between the ages of 55 and 70 * presence of subjective memory complaints as determined by the prospective- retrospective memory questionnaire * cognitively normal, e.g. score ≥26 on the montreal cognitive assessment exclusion criteria: * presence of obesity (body mass index \> 30 kg/m\^2) * presence of known cardiovascular disease * presence of type 2 diabetes * history of cardiovascular events requiring hospitalization in the past 3 years (e.g., heart attack, stroke) * history of concussion(s) with persistent symptoms * currently following a ketogenic diet and/or taking ketone body supplements * diagnosis of any form of alzheimer's disease or dementia

Keywords: beta-hydroxybutyrate (β-ohb) cerebral blood flow cognition brain connectivity
use of physiology to evaluate procedural result after pci cto

Conditions: Percutaneous Coronary Revascularisation; Complex Coronary Lesion

Summary: ultra-cto is a prospective multicentre non-randomised investigator-initiated trial designed to enrol 200 subjects with an indication for percutaneous coronary intervention (pci) of chronic total occluded (cto) coronary artery. the main objective of the study is to assess the predictive value of post-pci resting full-cycle ratio (rfr) and fractional flow reserve (ffr) with regard to fractional flow reserve (ssr) in cto patients.

ultra-cto is a prospective multicentre non-randomised investigator-initiated trial designed to enrol 200 subjects with an indication for pci cto. the main objective of the study is to evaluate both the value of post-pci rfr and post-pci ffr for detecting suboptimal stent result (ssr). after angiographically successful cto pci, intra-coronary physiologic assessment (rfr, ffr, coronary flow reserve (cfr) and index of microcirculatory resistance (imr)) of the cto vessel will be performed. additional oct will be performed directly or during a staged procedure within 4 ± 2 weeks when indicated (i.e. high contrast use, procedural duration, major dissection or other safety reasons according to the operator). when intra-coronary physiologic assessment or oct is not possible at all, the patients will not be included in the study. when the operator decides to optimize the stent result (post-dilation or additional stenting), based on the oct and/or physiology, post-pci rfr and ffr should be repeated. for patients undergoing a clinically indicated ffr of a remaining intermediate stenosis (angiographically 30-90%) in a non-cto vessel or major side branch of the cto vessel within 4 weeks after the index procedure, intra-coronary physiologic assessment (rfr, ffr, cfr and imr) will be repeated in the cto vessel for exploratory objectives at 4 ± 2 weeks follow-up, the occurrence of cardiovascular events and clinical classification will be assessed for secondary objectives

Eligibility criteria:
inclusion criteria: 1. age 18 years and older. 2. angiographically successful pci cto without any remaining lesion at least 30% proximal to the stented segment. 3. possibility to perform physiologic measurements and oct of sufficient quality. 4. patients willing and capable to provide written informed consent. exclusion criteria: 1) contra-indication for adenosine.

Keywords: percutaneous coronary intervention chronic total occlusion intra-coronary physiology optical coherence tomography
validation of a comprehensive health status assessment scale in elderly patients (≥ 65 years) with hematological malignancies

Conditions: Myelodysplastic Syndromes; Leukemia Myeloid Acute; Multiple Myeloma; Leuklemia, Lymphocytic, Chronic

Summary: the elderly comprise the most prevalent population in oncology practice. the available evidence suggests that old patients are undertreated patients, mainly because of their advanced age, regardless of whether they are highly functional patients, they do not present co morbidities and could benefit from oncology therapies. treatment planning must consider several health indices that are useful when it comes to detecting geriatric problems that could affect the patient's treatment experience. the complete comprehensive geriatric evaluation stands out as cornerstone among other validated tools that do not work as isolated instruments; however, its length and complexity may hinder its routine use in clinical practice for decision making. the purpose of this study is to validate a comprehensive health status assessment scale in elderly patients (≥65 years) with hematological malignancies that, while integrating the essential dimensions of geriatric assessment and, with the same precision as the currently available valid tools, is shorter and easier to apply, so it can be incorporated into the daily practice and that aids in clinical decision making objectively. if so, this information would help identify patients that could benefit from a specific oncology treatment, thus contributing to developing a targeted intervention plan and to optimizing the cancer results in this patient population.


Eligibility criteria:
inclusion criteria: patients ≥ 65 years old. treatment-naïve patients newly diagnosed patients who belong to one of the 3 following groups: patients with mds (any risk grade as per ipss) or aml patients with multiple myeloma (symptomatic or not) or patients with chronic lymphocytic leukemia (including a status) patients who have granted their informed consent. exclusion criteria: not fulfilling selection criteria

Keywords: haematological malignancy elderly health status scale validation