Kornimate/medical-research-clean huggingface dataset:
the effect of postoperative referred pain in the left shoulder on short-term outcomes for laparoscopic gastrectomy

Conditions: Stomach Neoplasms

Summary: the purpose of this study is to explore the effect of postoperative referred pain in the left shoulder on short-term outcomes for laparoscopic gastrectomy

a prospective cohort study will be performed to explore the effect of postoperative referred pain in the left shoulder on short-term outcomes for laparoscopic（including robot assisted laparoscopic surgery） gastrectomy .the evaluation parameters are overall postoperative morbidity rates,perioperative clinical efficacy and 3-year survival and recurrence rates.

Eligibility criteria:
inclusion criteria: * age from 18 to 75 years * primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or poorly differentiated) confirmed pathologically by endoscopic biopsy * ct1-4a, n0-3, m0 at preoperative evaluation according to the american joint committee on cancer (ajcc) cancer staging manual seventh edition * no distant metastasis is observed. and the spleen, pancreas or other adjacent organs are not involved by the tumor. * performance status of 0 or 1 on eastern cooperative oncology group scale (ecog) * american society of anesthesiology score (asa) class i, ii, or iii * written informed consent exclusion criteria: * patients whose previous history of chronic shoulder pain * women during pregnancy or breast-feeding * severe mental disorder * history of previous upper abdominal surgery (except laparoscopic cholecystectomy) * history of previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal dissection * enlarged or bulky regional lymph node envelop important vessels * history of other malignant disease within past five years * history of previous neoadjuvant chemotherapy or radiotherapy * history of unstable angina or myocardial infarction within past six months * history of cerebrovascular accident within past six months * history of continuous systematic administration of corticosteroids within one month * requirement of simultaneous surgery for other disease * emergency surgery due to complication (bleeding, obstruction or perforation) caused by gastric cancer * fev1\<50% of predicted values * difficulty of understanding v a s(visual analogues score).
the turkish deglutition handicap index

Conditions: Swallowing Disorder

Summary: the purpose of this study is to test the reliability and validity of the the turkish deglutition handicap index among adult patients with swallowing disorders.

the purpose of this study is to test the reliability and validity of the the turkish deglutition handicap index among adult patients with swallowing disorders.the internal consistency, test-retest reliability, and criterion validity of the instrument will be investigated. the internal consistency will be assessed using cronbach's alpha. intraclass correlation coefficient (icc) value with 95 % confidence intervals will be calculated for test-retest reliability. the criterion validity of the scale will be determined by assessing the correlation between the turkish deglutition handicap index and turkish eating assessment tool.

Eligibility criteria:
inclusion criteria: * willing to participate * having swallowing problems exclusion criteria: * being under the age of 20 years, and above the age of 60 years * not willing to participate * having no swallowing problems
comparison of different etco2 levels in preventing postoperative nausea and vomiting

Conditions: Postoperative Nausea and Vomiting

Summary: we aimed to evaluate the different etco2 levels (with the help of ultrasonographic optic nerve sheath diameter) in preventing gynecological laparoscopic surgeons' postoperative nausea induced by intracranial pressure change due to pneumoperitoneum and trandelenburg position.

although gynecologic laparoscopic surgery is a preferred technique in recent years due to its minimally invasive technique, the incidence of postoperative nausea and vomiting (ponv) is 53-72%. in such operations, intra-abdominal pressure due to trandelenburg position and carbondioxide insufflation causes intra-cranial venous obstruction and intra-cranial pressure increase. in addition, intra-cranial blood flow and ultimately intra-cranial pressure increase due to gravity and increased venous return resistance (peripheral vascular resistance). intra-cranial co2 concentration increase results in intra-cranial vascular dilatation, followed by icp increase. high intracranial pressure may cause an increase in the incidence of ponv after gynecological laparoscopic surgery. measurement of optic nerve sheath diameter with usg, a noninvasive method for detecting intracranial pressure increases, has been used frequently in intensive care units in recent years. we aimed to evaluate the different etco2 levels (during the operation with 10 minute intervals, and also with the help of ultrasonographic optic nerve sheath diameter) in preventing gynecological laparoscopic surgeons' postoperative nausea induced by intracranial pressure change due to pneumoperitoneum and trandelenburg position.

Eligibility criteria:
inclusion criteria: 25-50 age, asa i / ii, bmi: 18-33 kg/m2, operation time: 50-130 min., gynecological laparoscopy exclusion criteria: in previous operations, patients with postoperative nausea-vomiting (ponv) history, smoking, vehicle stays, liver and kidney dysfunction, abnormal fluid electrolyte balance, gastrointestinal system disease, preoperative antiemetic drug use, cerebral disease,dysrhythmia

Keywords: postoperative nausea and vomiting gynecological laparoscopic surgery end-tidal carbon dioxide
quick diagnostic program for head and neck cancer

Conditions: Cancer of Head and Neck

Summary: head and neck cancer would be suitable for quick diagnostic programs because their initial symptoms are easy detectable and the curation rates in the initial stages are very high. actually the stages at diagnosis are about 30% in initial stages and 70% in advanced stages. the hypothesis of this study is that a program for quick referral of patients with symptoms of head and neck cancer would help early diagnosis.


Eligibility criteria:
inclusion criteria: * patients with symptoms of head and neck cancer in the hospital reference area exclusion criteria: * patients already diagnosed when refered to hospital

Keywords: cancer diagnosis
mindfulness-based intervention for adolescents with chronic migraine

Conditions: Migraine; Migraine in Adolescence

Summary: the goal of this study is to assess feasibility and acceptability of a mindfulness-based intervention adapted for adolescents with migraine to inform a future randomized trial assessing effects of the intervention on headache-related outcomes.

mindfulness-based intervention (mbi) shows promise in adults with migraine, but research is limited in adolescents. the current study aims to advance behavioral treatments for adolescents with frequent migraine by adapting an existing empirically-supported mbi for adolescents (learning to breathe) to meet the unique needs of adolescents with chronic migraine. in phase i of the study, we will use feedback solicited from interviews with teens with chronic migraine, their parents, and healthcare providers documenting the experience of living with chronic migraine and on the content and delivery of the mbi to create an adapted telehealth group intervention specifically tailored for adolescents with frequent migraine. in phase ii of the study, the adapted mbi will be piloted in a single-arm trial with adolescents with frequent migraine to assess feasibility, acceptability, and preliminary clinical signals.

Eligibility criteria:
inclusion criteria: * age 13 to 18 years * diagnosed with migraine by medical provider using criteria from the international classification of headache disorders, third edition * patient report of \>= 8 headache days per month * pedmidas score of \> 10 (at least mild headache-related disability) exclusion criteria: * weekly or bi-weekly therapy with a licensed behavioral health provider * major comorbid medical condition (e.g., cancer, epilepsy) * active psychosis or suicidal ideation * inability to provide consent/assent

Keywords: adolescent mindfulness mindfulness intervention migraine headache
barriers and facilitators to cycling for lumbar spinal stenosis

Conditions: Lumbar Spinal Stenosis

Summary: the purpose of this study is to determine whether a home-based cycling program for patients with lumbar spinal stenosis is a feasible and acceptable

lumbar spinal stenosis is a prevalent and disabling condition in elderly individuals. lumbar spinal stenosis results in lumbar and/or radicular leg pain when standing and walking, while symptoms regress in lumbar flexion positions and at rest. the inability to stand or walk impairs functioning and health-related quality of life of elders, and has an important healthcare cost. the 2 main treatment options for lumbar spinal stenosis are conservative or surgical. laminectomy may be more effective on pain and function than conservative therapy. however, the benefit-risk balance of surgery should be considered in this population with numerous co-morbidities, and evidence is inconsistent. therefore, conservative therapy is usually the first line option to avoid or delay surgery. data regarding exercise therapy are scarce. lumbar-flexion-based exercises are usually recommended. a pilot study suggested that lumbar-flexion-based endurance training, namely cycling, could be an effective and safe method to improve pain, function and health-related quality of life in elderly patients with chronic low back pain but barriers to adhering to the program were detected. investigators aim to assess barriers and facilitators to a 3-month home-based cycling program in lumbar spinal stenosis.

Eligibility criteria:
inclusion criteria: * fulfilment of international society for the study of lumbar spine clinical diagnosis criteria for lumbar spinal stenosis with the presence of at least 6 out of the 7 following criteria: "pain in the buttocks or legs while walking"; "flex forward to relieve symptoms"; "feel relief when using a shopping cart or bicycle"; "motor or sensory disturbance while walking"; "normal and symmetric foot pulses"; "lower extremity weakness"; and "low back pain" * lumbar spinal stenosis qualitatively detected on mri or ct-scan exclusion criteria: * inability to speak or read french * impossibility or refusal to have an ergometric bicycle at home * ongoing lumbar-flexion-based endurance training * history of spinal surgery * cognitive impairment * neurological or vascular disorder involving the lower limbs * contraindication to cycling

Keywords: lumbar spinal stenosis cycling lumbar-flexion-based training
evaluation of the impact of a coordinating nurse in a personalized care program on quality of care, coordination of the actors and on quality of life for patients with lung cancer

Conditions: Lung Cancer

Summary: the prognosis of patients with lung cancer is related to the stage of the diagnosis : 73% of one-year-survival rate at stage ia and only 13% one-year-survival rate at stage iv. controlling the timelines in a care program seems crucial to improve prognosis of lung cancer. the project aims to evaluate the impact of a coordinating nurse (cn) in a personalized care program for patients of thoracic oncology.

new strategies therapeutics result in a longer survival rate. however their side effects affect the patient's quality of life. even if these side effects are ambulatory manageable, they require to be treated promptly and tends to increase the active list of patients of the thoracic oncology. due to the alteration in the care provided to lung cancer patient, there is a need to coordinate the available means, inside and outside the hospital, to improve the quality of care and the quality of life of the patient. every patient of the thoracic oncology department receives a personalized care program as a routine practice. in this study, a coordinating nurse (cn) will be added to the personalized care program. patients newly diagnosed with a lung cancer will be randomized either in the group with a cn or in the group without a cn. the study will last one year maximum for each participant. their quality of life, their satisfaction of the quality of the personalized care program - and their general practitioner's satisfaction - will be evaluated throughout the study.

Eligibility criteria:
inclusion criteria: * patient of the thoracic oncology ward between april and november 2016 * newly diagnosed lung cancer * treated in the pneumology ward of the mulhouse hospital (france) * patient enrolled in another clinical trial can also be enrolled in this study * patients who have not disagreed to participate to the study exclusion criteria: * secondary cancer in lung * relapse of primary cancer in lung of the same histological type * previous enrollment in this study * uncontrolled psychological problem

Keywords: coordinating nurse of thoracic oncology quality of care in thoracic oncology lung cancer quality of life
90% effective dose of norepinephrine infusions under intensive and standard treatment

Conditions: Adverse Effect

Summary: the objective of this study is to investigate the 90% effective dose of norepinephrine infusions for preventing postspinal anesthesia hypotension under intensive and standard treatment during cesarean section

post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for cesarean section. the incidence of post-spinal anesthesia hypotension is as high as 62.1-89.7% if prophylactic measures are not taken. the 2016 asa guidelines for obstetric anesthesia suggest avoiding hypotension following spinal anesthesia in women and emphasize the use of vasopressors, specifically alpha-receptor agonists, as the preferred strategy to prevent and manage post-spinal anesthesia hypotension. the 2018 international consensus in the united kingdom and northern ireland recommends maintaining maternal systolic blood pressure above 90% of the baseline value following lumbar anesthesia, while avoiding dropping below 80% of the baseline value. currently, the threshold for maintaining blood pressure above 80% of the baseline value is widely adopted as a standard; however, limited evidence supports the advantage of sustaining maternal blood pressure above 90% of the baseline value. the objective of this study is to investigate the 90% effective dose of norepinephrine infusions for preventing postspinal anesthesia hypotension under intensive and standard treatment during cesarean section.

Eligibility criteria:
inclusion criteria: * 18-45 years * primipara or multipara * singleton pregnancy ≥37 weeks * american society of anesthesiologists physical status classification i to ii * scheduled for cesarean section under spinal anesthesia exclusion criteria: * body height \< 150 cm * body weight \> 100 kg or body mass index (bmi) ≥ 40 kg/m2 * eclampsia or chronic hypertension or baseline blood pressure ≥180 mmhg * hemoglobin \< 7g/dl * fetal distress, or known fetal developmental anomaly
bilateral external oblique intercostal plane block in post operative pain management in hepatectomy

Conditions: Provide Post Hepatectomy Pain Control

Summary: the majority of cases undergoing hepatectomy suffer from inadequate postoperative analgesia. therefore, multimodal analgesic techniques are required to relieve pain and discomfort such as intravenous, and epidural analgesia, and peripheral nerve blocks. although epidural catheters are efficient to provide perioperative analgesia, in this type of surgery patients may be more susceptible to catheter related complications due to the alteration in coagulation parameters. that is why safer alternatives are sought for those patients. the use of patient-controlled analgesia (pca) for postoperative pain management improves patients' quality of recovery. however, there are many concerns regarding the type of opioids used in pca such as overdosing, underdosing, and the effect of the hepatectomy on the drug metabolism in those patients. external oblique intercostal plane block (eoi block) is a relatively novel block used in upper abdominal incisions especially subcostal laparotomy to provide intraoperative and postoperative analgesia. this study aims to compare the efficacy of bilateral external oblique intercostal plain block versus pca in pain management and reduction of opioid use in hepatectomy surgery done by subcostal incision.


Eligibility criteria:
inclusion criteria: * age ≥ 18 and ≤ 65 years. * both sexes. * patients will be scheduled for hepatectomy surgery. * body mass index (bmi) 18.5-30.0 /m 2 . exclusion criteria: * extension of the surgical incision beyond coverage of t12 dermatome. * prolonged time of surgery \&gt; 5 hours. * hepatectomy surgery combined with another organ resection. * patients with hypersensitivity to local anesthetics. * history of psychiatric problems. * recent history of analgesic drugs including opioid abuse or addiction. * coagulopathy (international normalized ratio \[inr\] \&gt; 1.4). * localized infection at the block site. * morbidly obese patients.

Keywords: external oblique intercostal block subcostal incision hepatectomy patient control analgesia
wolffia globosa (mankai) and glycemic control among patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the investigators primarily aim to explore the effect of daily additive supplementation of mankai on glucose control among participants with t2d.

type 2 diabetes is a major public health concern in western societies. type 2 diabetes is associated with high morbidity and shorter life expectancy. in patients with type 2 diabetes maintaining glycemic control is associated with lower rates of complications and mortality associated with the disease. thus, there is a great need to recognize nutritional elements that improve glycemic control and insulin sensitivity in patients with type 2 diabetes. mankai, a strain of wolffia globosa recently developed under controlled conditions, is characterized by high protein content and good bioavailability of proteins, rich in soluble fiber, vitamins (including vitamin b12), minerals (including iron and zinc), omega 3 fatty acids, and polyphenols. the 18-month long direct plus trial was a weight-loss intervention conducted among 294 participants with abdominal obesity or dyslipidemia. 98 of the study participants were assigned to the intervention of a green mediterranean diet and were instructed to consume four frozen cubes of mankai daily. main conclusions from the direct plus refer to the beneficial effect of the green-mediterranean diet on cardiometabolic risk, gut bacteria, and liver fat, with no evidence of disadvantages or adverse effects of long-term mankai consumption. in 2019, the investigators reported that among non-diabetics and those with fasting glucose levels within the normal range, consuming a mankai smoothie in the evening led to lower glucose levels after the meal and lower fasting overnight compared to a yogurt smoothie. the investigators now plan to explore the effect of mankai daily supplementation on post-meal glycemic response in participants with type 2 diabetes. the investigators hypothesize that the addition of mankai consumption after a meal may mitigate glucose excursions compared with control.

Eligibility criteria:
inclusion criteria: * age =\> 30 years * a formal diagnosis of t2d (126mg/dl fasting glucose or higher, or hba1c=\>6.5%) or taking t2d medications. exclusion criteria: * treatment with coumadin (warfarin) * advanced renal failure * a significant illness that might require hospitalization * state of pregnancy or lactation * presence of active cancer or chemotherapy treatment in last three years * participation in another trial.
cognitive rehabilitation and fes for hand functionality in persons with cervical spinal cord injury

Conditions: Spinal Cord Injury at C5-C7 Level

Summary: 16 persons affected by cervical-sci were recruited for the study and randomly assigned to the control group (cg) or to the experimental group (eg). persons of the cg (n = 8) executed 20 sessions of fes for the rehabilitation of hand functions (grasp or pinch), participants of the eg (n = 8) performed 20 sessions of fes and cba in addition. the primary assessment was a modified version of bimanual activity test (10 tasks); also, scim-ii and measurement of grasping strength only in participants submitted to grasp rehabilitation were evaluated.

each participant followed twenty sessions of hand rehabilitation, three times per week. each treatment, for both cg and eg, lasted about forty minutes. the fes devices chosen for this research stimulated "grasp" or "pinch" function: the ness h200 (ness ltd., ra'anana, israel) was used if patient needed to improve the grasp functions, otherwise the microstim (microstim, medel, hamburg, germany) was used to increase pinch functions. in order to provide fes, the five electrodes of ness h200 were first humidified with warm water and then inserted in the right size place of the rigid splint worn by the patient, while microstim was used with four standard electrodes, two for each muscle treated. in both case the stimulation was triggered by the therapist clicking a button (table 1). the participants of cg received only fes to improve their manipulating skills without the interaction with objects, but only with the muscle contraction induced by the devices. the participants of eg executed fes and cba treatment which means that during the stimulation they manipulated different tools. in particular, for the first ten sessions the participants were invited to manipulate specific objects: squares, rectangles and pyramids of different sizes; touch on plastic test tubes coated with materials of different consistency; these two exercises were performed both with open and closed eyes. finally, for the last ten sessions the participants were asked to execute specific tasks, depending on person's life before the lesion.

Eligibility criteria:
inclusion criteria: * c-sci with neurological level between c2-t1; * reduced ability of hand functions; * excitable muscles and fes tolerability. exclusion criteria: * any trauma or surgery to the target hand or upper limb within the last 12 months, * amputation of any digits on the target hand, * severe spasticity in the target hand or upper limb preventing use of the instruments, * experienced autonomic dysreflexia or hypotension in response to fes, * any contraindication to fes such as: cardiac pacemaker, epilepsy, forearm fracture, pregnancy, skin lesions, cancer or tumor, intracranial metal implants
functional dyspepsia response to relaxation therapy and physical activity

Conditions: Dyspepsia

Summary: functional dyspepsia (fd) is a common gastrointestinal disease with high morbidity. due to the drop in estrogen level, perimenopausal women with fd (pmfd) have an increase in emotional disorders such as depression, anxiety and sleep disorder.

the research will include 30 fd women during their perimenopause to receive for 8 weeks the following: relaxation therapy (benson relaxation), physical exercise (on treadmill), and proton pump inhibitors. also, the research will include another 30 fd women during their perimenopause to receive for 8 weeks the following: relaxation therapy (benson relaxation) and proton pump inhibitors

Eligibility criteria:
inclusion criteria: * perimenopausal women with fd symptoms exclusion criteria: * other gastrointestinal disease * cardiovascular, metabolic, respiratory, renal complaints * pregnancy * women in lactation * neurological / psychic women