Kornimate/medical-research-clean huggingface dataset:
recognizing pain intensity in alzheimer's disease

Conditions: Alzheimer Disease; Pain; Autonomic Nervous System Disease

Summary: the most common form of dementia is alzheimer's disease, with 900,000 people affected in france in 2015 and a forecast of 1.3 million in 2020. as a consequence of their advanced age, dementia patients often suffer from pain, mainly musculoskeletal or neuropathic pain. however, the exact prevalence of pain in dementia is underestimated. indeed, several studies indicate that people suffering from dementia report less pain. this phenomenon is all the more true as the stage of dementia is advanced. in addition, people with dementia receive less pain medication than people without cognitive impairment in similarly painful conditions. hetero-evaluation alone also seems insufficient, with the result that pain is under-treated compared to patients without cognitive impairment. better pain screening is a major challenge and self-assessment tools should be favoured as a first line of treatment, even for patients with cognitive impairment. suffering from dementia. the investigators propose in this work to evaluate the variation of vegetative parameters that accompany a painful stimulus. these variations can be recorded at the cardiac, vascular, pupillary or skin conductance level.

it will therefore be a question of inducing experimental pain in patients with alzheimer's disease, in the early stages of the disease and to check whether pain-related changes in the autonomic nervous system via the nociception level index (nol® system) differ from a control group of subjects matched in age, gender and education level. to induce pain, the investigators will use the "cold pressor test" technique, which consists of leaving the arm immersed in ice water for as long as the pain is bearable. the investigators will also record before, during and after the immersion, the variations of several parameters derived from the autonomic nervous system during the painful stimulation via the nol® system. during this experience, the participants will be filmed in their entirety to observe the facial emotions related to pain.

Eligibility criteria:
inclusion criteria for patients with alzheimer's disease : * diagnosis of the disease by a hospital doctor after an etiological assessment including at least a cerebral mri, a neuropsychological assessment and, if possible, dementia markers in the cerebrospinal fluid. * mini mental state score \> 23 inclusion criteria for control subject : - matching by age (± 5 years), gender, and grade level exclusion criteria for 2 groups : * presence of pain, * presence of mood and/or psychiatric disorders (had a ou a scores \>7). * presence of cardiovascular risk factors and beta-blocker and/or calcium channel blocker therapy. * patients under guardianship or curatorship

Keywords: facial emotion
the effects of different outdoor light exposure modes on retinal blood flow

Conditions: Myopia

Summary: in 2020, the overall myopia rate among children and adolescents in my country was 52.7%. the covid-19 pandemic has increased students' time of indoor eye-using, and it showed that the light exposure intensity of myopic students is lower than that of non-myopia students. studies have found that the light wave bandwidth has a significant impact on the emmetropization of the eye, and white light can promote emmetropia more than monochromatic light. it shows that outdoor exercise has a protective effect on the occurrence and development of myopia in children and adolescents, but the specific mechanism is still unclear. retinal blood flow is sensitive to myopic stimuli, and is a short-term indicator of the relationship between light environment and myopia. this study selected retinal blood flow as the primary outcome, aiming to compare the effects of different outdoor light exposure modes on retinal blood flow after 1 hour of intense eye use, and provide clues for the prevention and control of myopia.

in 2018, eight departments including the ministry of education jointly issued the implementation plan for comprehensive prevention and control of myopia in children and adolescents. as of 2020, the overall myopia rate among children and adolescents in my country was 52.7%. the covid-19 pandemic has increased students' time of indoor eye-using, and it showed that the light exposure intensity of myopic students is lower than that of non-myopia students. studies have found that the light wave bandwidth has a significant impact on the emmetropization of the eye, and white light can promote emmetropia more than monochromatic light. it shows that outdoor exercise has a protective effect on the occurrence and development of myopia in children and adolescents, but the specific mechanism is still unclear. retinal blood flow is sensitive to myopic stimuli, and is a short-term indicator of the relationship between light environment and myopia. also, there is a theory that reduced choroidal blood flow causes scleral hypoxia, which leads to the development of myopia. therefore, this study selected retinal blood flow as the primary outcome, aiming to compare the effects of different outdoor light exposure modes on retinal blood flow after 1 hour of intense eye use, and provide clues for the prevention and control of myopia.

Eligibility criteria:
inclusion criteria: * school students aged from 7 to 15, regardless of sex or gender; * diopter between -2.0d and 3.0d, and astigmatism not exceed 0.75d; * no organic disease and in good general condition; * have obtained the consent of their parents or guardians, and can cooperate. exclusion criteria: * suffering from amblyopia, strabismus, color weakness, congenital cataract, glaucoma and other eye diseases; * other circumstances judged by the investigator to be unsuitable to participate in the research.

Keywords: myopia retinal blood flow accommodative micro-fluctuation outdoor light exposure
oral vinorelbine as induction chemotherapy followed concomitant chemoradiotherapy

Conditions: Lung Cancer

Summary: patients (pts) with stage iiia/iiib nsclc received nvbiv 25 mg/m² + cddp 80 mg/m² on d1 and nvbo 60 mg/m² on d8 every 3 weeks (q3w) for 2 cycles as induction. pts with response or non change received nvbo 20 mg fixed dose on d1 d3 d5 + cddp 80 mg/m² on d1 q3w for 2 more cycles during rt(66 gy/6.5 w).

vinorelbine (nvb) + cddp is considered a standard trt in induction or concomitantly with rt (vokes, fournel, krzakowski). nvbo simplifies the administration of trt and provides the same efficacy as intravenous nvb (nvbiv). in order to assess this and to improve the tolerance, a trial was started with nvbiv and nvbo + cddp as induction followed by a fractionated administration of nvbo + cddp during rt.

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed stage iiia (only n2), * dry iiib previously untreated inoperable nsclc, * 18 to 75 years old, * karnofsky performance status (kps) ≥ 80%, * weight loss ≤ 10% within the previous 3 months, * normal organ functions were eligible. * at least one measurable lesion according to response evaluation criteria in solid tumors (recist version 1.0) \[10\]. exclusion criteria: * stages i, ii, iiia (excepted n2), iiib with pleural effucion and stage iv, * pregnant or breastfeeding women. women of childbearing age: women of childbearing potential should take reliable contraceptive measures * symptomatic neuropathy \> grade 1, * associated pathology and/or not controled diseases(cardiac insuficiency, myocardial infarction within 3 months before the inclusion ; hypertension, arythmia or uncontroled hypercalcémia; infection requiering iv antibiotic administration within 2 weeks before inculion), * other associated cancer with the exception of cervical carcinoma in situ or skin cancer baso-cellular correctely treated, * previous treatment with an other antineoplasic, * known hypersensibility to drugs with a similar chemical structure ti this studied. * important malabsorbtion syndrom or disease of gastro-intestinal track, * participation to another clinical trial within 30 days before inclusion
comparison cytokine clearance between sled-f using high cut-off dialyzer and high-flux dialyzer in septic aki patients

Conditions: Sepsis; Acute Kidney Injury

Summary: hypercytokinemia contributes a major role in the pathogenesis and is associated with the high mortality in sepsis-related acute kidney injury(aki). this pilot randomized controlled trial was conducted in sepsis-related aki patients to compare the efficacy of cytokine removal including interleukin(il)-6, il-8, il-10, and tumor necrotic factor(tnf)-α by six-hour sled-f between using hco dialyzer(hco-sled-f) and hf dialyzer(hf-sled-f).

hypercytokinemia contributes a major role in the pathogenesis and is associated with the high mortality in sepsis-related acute kidney injury(aki). reductions of these cytokines have been reported to improve clinical outcomes. online sustained low-efficiency diafiltration(sled-f) using traditional high-flux(hf) dialyzer could remove some cytokines. interestingly, the potential of enhancing cytokine removal by using newly designed high cut-off(hco) dialyzer that could theoretically remove larger molecular weight solutes has never been studied in sled-f before.this pilot randomized controlled trial was conducted in sepsis-related aki patients to compare the efficacy of cytokine removal including interleukin(il)-6, il-8, il-10, and tumor necrotic factor(tnf)-α by six-hour sled-f between using hco dialyzer(hco-sled-f,n=8) and hf dialyzer(hf-sled-f,n=8).

Eligibility criteria:
inclusion criteria: * sepsis * acute kidney injury stage 3 exclusion criteria: * profound hemodynamic instability with more than one inotropic drug * pregnancy * breast-feeding * delayed receiving antibiotic up to 6 hours after beginning of septic shock.

Keywords: sustained low-efficiency diafiltration (sled-f) high cut-off dialyzer cytokines
beyfortus™ (nirsevimab) effectiveness against medically-attended rsv events in infants (bear study)

Conditions: Respiratory Syncytial Virus

Summary: the primary objectives of the study are: to estimate the effectiveness of nirsevimab against polymerase chain reaction (pcr)-confirmed rsv (1) lower respiratory tract (lrtd) and (2) related medical encounters. the secondary objectives are: 1. to estimate the effectiveness of nirsevimab against medical encounters with a respiratory related diagnosis. 2. to estimate the effectiveness of nirsevimab against medical encounters with an lrtd diagnosis. 3. to estimate the impact of nirsevimab on pcr-confirmed rsv. 4. to estimate the impact of nirsevimab on medical encounters with an otitis media diagnosis. 5. to estimate the impact of nirsevimab on antibiotic prescription.


Eligibility criteria:
inclusion criteria: * the kaiser permanente northern california, usa (kpnc) member born on or after 01 april 2023 for cohort 1 and cohort 2. * eligible to receive nirsevimab as defined by the product indication. * kpnc infants entering their first rsv season. exclusion criteria: * mother was administered an rsv vaccine during her pregnancy with the infant participant. * mother of infant participant was not a kpnc member during pregnancy. * mother did not deliver the infant participant at a kpnc facility. * infant receipt of other rsv pre-exposure prophylaxis (ie, palivizumab). note: the above information is not intended to contain all considerations relevant to a potential participation in a clinical trial.

Keywords: rsv
multidetector ct left appendage atrial thrombosis exclusion in patients with atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the aim of the late (multidetector ct lefi appendage atrial thrombosis exclusion in patients with atrial fibrillation) study is to evaluate the diagnostic accuracy of cardiac computed tomography (tc) with 64 detectors and double acquisition phase in candidate patients ablation of atrial fibrillation (af) with the navx (or carto) technique, using trans-esophageal ultrasound (tee) as the standard reference. this study is based on the use of an experimental protocol in cardiac tc which involves, in addition to the acquisition of an early arterial phase (standard protocol routinely performed in all patients), the execution of a possible late phase at a very low dose of radiation (experimental protocol) aimed at increasing the accuracy of the method in the diagnosis in patients with af. the late study aims to demonstrate the high diagnostic accuracy of dual acquisition phase cardiac tc in the diagnosis of intraauricular thrombosis by comparing it with reference standard; in light of this result, cardiac tc could constitute a single non-invasive diagnostic tool in the future for the global evaluation of both atrial anatomy and endoawicular thrombosis with a clear improvement in patient management both in clinical and economic terms.


Eligibility criteria:
inclusion criteria: * patients candidates for cardiac tc and transesophageal ultrasound examination for the evaluation of cardiac anatomy and for the exclusion of intra-auricular thrombosis. exclusion criteria: * \< 18 years patients
laparoscopic banded sleeve gastrectomy

Conditions: Obesity, Morbid; Surgery

Summary: laparoscopic sleeve gastrectomy (lsg) is now the most common bariatric procedure to treat morbidly obese patients. the main concern of lsg lies in the long-term weight regain which is reported to happen in up to 75.6% of patients after 6 years. the investigators report the overall experience with laparoscopic banded sleeve gastrectomy (lbsg) using the minimizer over a six-year period.

introduction. laparoscopic sleeve gastrectomy (lsg) is now the most common bariatric procedure to treat morbidly obese patients. the main concern of lsg lies in the long-term weight regain which is reported to happen in up to 75.6% of patients after 6 years. the investigators report the overall experience with laparoscopic banded sleeve gastrectomy (lbsg) using the minimizer over a six-year period. methods. the investigators performed a retrospective review of data from a prospectively collected database. all patients submitted to primary lbsg were examined. patients were submitted to lbsg between february 2014 and january 2020. collected data included demographic factors, pre-operative weight, pre-operative bmi, operative time, surgical complications, and clinical outcomes in terms of short and mid-term weight loss.

Eligibility criteria:
inclusion criteria: * severe obesity with bmi \> 35 kg/m2 exclusion criteria: * alcoholism * drug addiction * psychiatric disease

Keywords: sleeve gastrectomy banded sleeve gastrectomy laparoscopy bariatric surgery obesity
study to evaluate the safety and tolerability of a nasal spray in patients with chronic allergic or nonallergic rhinitis

Conditions: Chronic Allergic Rhinitis; Nonallergic Rhinitis

Summary: the purpose of this study is to determine if astepro nasal spray (0.1% azelastine hydrochloride) is as safe as astelin nasal spray (0.1% azelastine hydrochloride)


Eligibility criteria:
inclusion criteria: 1. male and female patients 12 years of age and older with an established history (\> 1 year) of rhinitis due to perennial allergies, non-allergic triggers or vasomotor rhinitis (vmr). 2. provide written informed consent/pediatric assent. if the patient is a minor, a parent or legal guardian must give written informed consent 3. willing and able to comply with the study requirements, including daily use of medication for a one year period, even if symptoms are not bothersome. 4. general good health and free of any disease or concomitant treatment that could interfere with the interpretation of the study results as determined by the investigator or the sponsor's medical officer 5. patients receiving immunotherapy (antigen desensitization) must be on a stable maintenance regimen for at least 30 days before the first study visit (adjustments to regimen following a brief period of missed injections does not preclude participation) exclusion criteria: 1. the use of any investigational drug within 30 days prior to screening. no other investigational products are permitted for use during the conduct of this study 2. presence of any hypersensitivity to drugs similar to azelastine and to either sorbitol or sucralose (splenda® brand sweetener) 3. women who are pregnant or nursing 4. women of childbearing potential who are not abstinent and not practicing a medically acceptable method of contraception. female patients must practice an acceptable contraceptive technique for 30 days before randomization and agree to continue its use during treatment and for 30 days after the last dose of study drug. oral, intrauterine, implantable, injectable contraceptives, or a double barrier form of contraception are acceptable and the medication including dose, device or method must have been stable for at least 30 days before the first dose of study drug. 5. nasal disease(s) likely to affect deposition of intranasal medication, such as sinusitis,rhinitis medicamentosa or clinically significant nasal polyposis or nasal structural abnormalities 6. patients with asthma (with the exception of mild, intermittent asthma) or other significant pulmonary disease such as chronic obstructive pulmonary disease 7. patients with a known history of alcohol or drug abuse 8. existence of any surgical or medical condition, which in the opinion of the investigator or sponsor, might significantly alter the evaluation of study 9. clinically relevant abnormal history and/or physical findings which, in the opinion of the investigator or sponsor, would interfere with the objectives of the study or that may preclude compliance with the study procedures 10. study site staff, immediate relatives of study site staff, or other individuals who would have access to the clinical study protocol
characterisation of low frequency hearing and vestibular function in patients undergoing cochlear implantation

Conditions: Hearing Loss, Sensorineural; Hearing Loss, Bilateral

Summary: the study will follow a cohort of ci-candidates becoming ci-user, till two years postoperative. a through-out assessment of both their audiological and vestibular status will be carried out at multiple fixed timepoints over 2 years, evaluating both subjective (patients reported) and objective outcomes over time. for the audiological part of the study both pure-tone and speech audiometry results will be held against the patient perceived benefit of the treatment as assessed by the questionnaires nciq and ssq-12. the vestibular part of the study will evaluate the function of the sccs and the sacculus. this is will be put in concert with functional tests of the vestibular system, and the patient perceived outcome measure dhi. correlations between vestibular and audiological performances will be examined. a collection of specific hypotheses will be tested by predefined statistical methods.


Eligibility criteria:
inclusion criteria: * adults (at or above 18 years of age and capable of giving an informed consent) * cochlear implant candidacy * profound bilateral post-lingual hearing loss * proficiency in danish * expected ability to participate on both all pre- and postoperative examinations * no previous ci experiences exclusion criteria: * later abandonment of ci candidacy * blindness or visual handicap compromising eye movement evaluation * distinct neck mobility handicap hindering either vhit- or cvemp examination * patient reluctance, such as consistent no-show or cancellations of appointments * ci-surgery before preoperative evaluation could be obtained * simultaneous bilateral cochlea implantation. * sequential ci within the follow-up period

Keywords: cochlear implant residual hearing hearing preservation
the effect of dual task training in patients with stroke

Conditions: Stroke

Summary: the aim of this study was to investigate the effect of dual-task training on gait, balance, and quality of life in individuals with stroke. the study included 30 individuals aged 30-80 years with stroke. all participants were assessed using the 10-meter walk test (10mwt), 10mwt under dual-task interaction (dti), timed up and go (tug), 30-second chair-stand test (30s-cst), berg balance scale (bbs), short form 36 (sf-36). participants were randomized into two groups. both groups received conventional physiotherapy for approximately 1 hour, five days a week. group i also received dual-task training.


Eligibility criteria:
inclusion criteria: * having a score of 24 or above on the mini-mental state test, * being able to walk at least 10 meters without using a walking aid * having a total score of 5 on the motor and cognitive sections of the functional independence scale. exclusion criteria: * neurological and orthopedic problems that could affect motor performance and balance * communication problems * patients who had received botulinum toxin injection treatment in the last six months
effects of relaxation and guided imagery training on pain at childbirth

Conditions: Pain at Childbirth

Summary: the purpose of this study is to determine whether relaxation and guided imagery techniques are effective in reducing childbirth pain.


Eligibility criteria:
inclusion criteria: * women who carry their first child * women that carry only one embryo * women who speaks hebrew exclusion criteria: * women who experienced complications in pregnancy. * women who planning on having an elective caesarean section. * women who suffer from background systematic condition (such as high-bp, diabetes). * women who have psychiatric background. * women who take chronic medication that might effect childbirth, woman or baby's health.

Keywords: pain childbirth relaxation guided imagery vas epidural
3d ultrasound, specimen examination by surgeon, and mri in surgical margin assessment

Conditions: Squamous Cell Carcinoma; Tongue SCC; Head and Neck Cancer

Summary: in the current protocol, application of 3d ex-vivo ultrasound, mri, and clinical evaluation (palpation and examination) by the surgeon is proposed to analyze the margin status in tongue squamous cell carcinoma and correlate the results to the histopathology findings.

cancer surgery is the primary treatment in the early stages of tongue squamous cell carcinoma (scc), and the goal is the complete resection of the tumor with an adequate margin of healthy tissue around to ensure proper cancer removal. inadequate margins lead to a high risk of local cancer recurrence and the patient will need re-surgery or adjuvant therapies. ex-vivo imaging of the resected surgical specimen has been suggested to provide information for margin assessment and thus improve cancer surgery. in this manuscript, a protocol to investigate the clinical benefit of three-dimensional (3d) ultrasound imaging of the surgical margins and comparing the results to magnetic resonance imaging (mri) and the clinical examination of the surgical specimen by surgeon (palpation to inspect the resected tissue) has been designed. tumor segmentation and margin measurement (anterior towards apex of tongue, posterior towards base of tongue, medial towards back of tongue, lateral towards floor of mouth, and profound/deep margins) will be performed by head and neck surgeons on 3d ultrasound images and by two consultant radiologists on mri of the ex-vivo specimen. accuracy of each method will be evaluated by computing the proportion of correctly classified margins (positive, close, and free) by each technique with respect to the gold standard histopathology.

Eligibility criteria:
inclusion criteria: * patients with biopsy-proven oral tongue squamous cell carcinoma scheduled for surgical treatment * t1-t3 staging on cross-sectional imaging exclusion criteria: * t4 staging * unable to understand the verbal or written information * prior radiotherapy treatment of oral cavity cancer

Keywords: ultrasound 3d ultrasound ultrasonography three dimensional imaging cancer diagnosis surgical margin assessment magnetic resonance imaging mri ex-vivo surgical specimen imaging squamous cell carcinoma histopathology scc oral cancer