Kornimate/medical-research-clean huggingface dataset:
promoting success for pre-k teachers, families and children

Conditions: Emotional Stress

Summary: the current study examines the impact of parentcorps in high-poverty early education centers in new york city (nyc). the study is conducted within the context of the nyc department of education (doe) pre-k thrive initiative. as part of this initiative, the center for early childhood health and development (cehd) at nyu langone health is implementing services to strengthen family engagement and support parents and teachers in building safe, nurturing and predictable environments for young children. services include resources to support social emotional learning (sel) and family engagement (fe) for all pre-k for all (pkfa) programs and all pkfa families; professional learning to support the use of evidence-based sel and fe practices for teachers and leaders from 350 pkfa programs; and parentcorps programs for pkfa children and families in 50 pkfa programs (which is a subset of pkfa programs receiving professional learning). the current study evaluates the relative value of thrive professional learning plus parentcorps compared to thrive professional learning. this study will include 158 pre-k teachers (teachers and teaching assistants) across 23 centers (12 centers receiving thrive professional learning plus parentcorps, 11 centers receiving thrive professional learning only). all teachers in the 23 centers will be invited to complete 2 self-report surveys over a two-year period. a sub-set of teachers will be randomly selected to participate in 2 interviews during this period. in addition, teachers in sites randomized to parentcorps (12 centers) will be invited to consent to the use of weekly implementation surveys, observational data and semi-structured interviews about experiences with implementation, collected as part of standard implementation practice of parentcorps, for the purposes of this study.


Eligibility criteria:
inclusion criteria: * teachers who are teaching staff in the pre-k classrooms in the 23 centers. exclusion criteria: * only pre-k teachers from the 23 centers will be invited to participate in the study. leaders and other school staff from the centers are excluded from the study. * family-level administrative data only on pre-k families from the 12 centers assigned to the professional learning plus parentcorps condition will be obtained from the nyc doe. families in other sites are excluded from the request for family-level administrative data.

Keywords: socio economic adversity child development poverty racial disparity ethnic disparity
l-dep regimen combined with pd-1 antibody as induction therapy for epstein-barr virus-positive la-hlh

Conditions: PD-1 Antibody; Hemophagocytic Lymphohistiocytosis; Epstein-Barr Virus; Lymphoma

Summary: the efficacy and safety of l-dep (peg-aspargase, liposomal doxorubicin, etoposide, and methylprednisolone) regimen combined with pd-1 antibody an induction therapy for epstein-barr virus (ebv)-positive lymphoma-associated hemophagocytic lymphohistiocytosis.

lymphoma-associated hemophagocytic lympohistiocytosis is a refractory immune disorder with high mortality. without early intervention, the median survival time is less than 2 months. currently, hlh-94 or hlh-04 are the standard hlh treatment regimens, which have improved the disease response rate to approximately 70% and increased the 5-year os rate to 50%. however, approximately, 30% of the patients remain unresponsive to standard therapy, especially if hlh is lymphoma-associated. therefore, we conduct a prospective clinical study to explore the efficacy and safety of l-dep (peg-aspargase, liposomal doxorubicin, etoposide, and methylprednisolone) regimen combined with pd-1 antibody an induction therapy for epstein-barr virus (ebv)-positive lymphoma-associated hemophagocytic lymphohistiocytosis.

Eligibility criteria:
inclusion criteria: * diagnosed as lymphoma-hemophagocytic lymphohistiocytosis. * ebv-dna in peripheral blood \> 1000 copies/ml or eber detected in tissue specimens. * age 18\~65，gender is not limited. * estimated survival time ≥ 1 month. * cardiac ultrasound lvef≥50%; no active bleeding of the internal organs(digestive tract, lung, brain, etc.); if the patient has dyspnea, oxygenation index \>250. * signed informed consent. exclusion criteria: * heart function above grade ii (nyha). * severe myocardial injury：tnt、tni、ck-mb \> 3 uln. * accumulated dose of doxorubicin above 400mg/m2 、epirubicin above 750mg/m2、pirarubicin above 800mg/m2 or the patients treated with anthracycline induced cardiovascular disease. * pregnancy or lactating women. * allergic to pegylated liposomal doxorubicin，etoposide，or pd-1 antibody. * thyroid dysfunction. * hiv antibody positivity. * acute or chronic active hepatitis b (hbsag positivity, hbv dna negative acceptable), acute or chronic active hepatitis c (hcv antibody negatively acceptable; hcv antibody positivity, hcv rna negative acceptable). * participate in other clinical research at the same time. * the researchers considered that patients are not suitable for the study.
use of synvisc® in knee osteoarthritis - medico-economical study

Conditions: Osteoarthritis

Summary: the usage study aims at assessing on a long-term period (two years in average) the outcome in clinical or economical term of patients with knee osteoarthritis (oa) treated or not with synvisc®, in the 1139.4 clinical trial.


Eligibility criteria:
inclusion criteria: * patients have already been followed up on a nine-month period in a pragmatic medica-economical clinical trial (bi trial no.: 1139.4) exclusion criteria: * none
reduce emotional symptoms of insomnia with sleeptreatment

Conditions: Insomnia; Rumination

Summary: the purpose of this research is to test whether mindfulness-based therapy for insomnia (mbti) significantly reduces symptoms of insomnia and cognitive arousal in patients with treatment-resistant insomnia.

cognitive-behavioral therapy and pharmacotherapy are effective interventions for insomnia. even so, about half of patients do not adequately respond to these treatments. non-remission has been linked to high cognitive arousal that does not improve with traditional therapies. this study will examine the effects of mindfulness-based therapy for insomnia (mbti) in a sample of patients who previously failed cognitive behavioral therapy and/or pharmacotherapy for insomnia. this trial utilizes a single-arm, open label trial of mbti. mbti is delivered via telemedicine video in an individual therapy format. male and female participants who have insomnia, are age 18 and older, and who are recruited into the study will complete an initial assessment of their qualifications that are based on the severity of their insomnia symptoms, depression symptoms, and physical and mental health status. eligible participants will undergo a clinical sleep interview and then complete 8 sessions of mbti. study outcomes are assessed via online survey before treatment, after treatment, and then a 6-month follow-up.

Eligibility criteria:
inclusion criteria: * determination of insomnia (isi\>10) * inadequate response to prior insomnia psychotherapy (e.g., cbti) and/or pharmacotherapy per patient report. exclusion criteria: * age \< 18 * current use of antidepressants for depression * bipolar or seizure disorders * known sleep disorders other than insomnia (e.g. obstructive sleep apnea, narcolepsy, restless leg syndrome).

Keywords: insomnia nocturnal rumination depression mindfulness mindfulness-based therapy for insomnia
breathe long-term follow-up study

Conditions: Chronic Sinus Disease

Summary: this is a long-term follow-up of patients that participated in the breathe i study.


Eligibility criteria:
inclusion criteria: * participated in breathe i study * willing to sign consent and participate in long-term follow-up study exclusion criteria: * none
body surface area prediction impacts on ventricular dilatation prevalence

Conditions: Cardiomyopathies

Summary: the goals of this observational study are to investigate the accuracy of different predictive equations for body surface area (bsa) estimation and to evaluate the impact of different bsa normalizations on ventricular dilatation prevalence in youth soccer players. two convenience samples of young soccer players of both genders will be recruited. acquisition of optical images (for the players of the first sample), two-dimensional echocardiographic assessment (for the players of the second sample), and weight and height measurements (for the players of both samples) will be performed. bsa estimates will be derived from optical images (for the players of the first sample) and from ten different predictive equations obtained from the literature (for the players of both samples). comparisons between optical imaging - derived bsa and bsa estimates obtained with the ten predictive equations will be performed for the players of the first sample. absolute and relative values of different echocardiographic variables will be considered for the players of the second sample to assess the ventricular dilatation prevalence.


Eligibility criteria:
inclusion criteria: * healthy subjects * regular sports participation exclusion criteria: - athletic heart syndrome

Keywords: 3-d optical imaging body surface area soccer transthoracic echocardiography
assessment of maxillary acrylic resin complete dentures reinforced by gold plated cr-co palatal plate

Conditions: Denture Stomatitis

Summary: gold is widely used in prosthetics. its use ranges from being employed in the fabrication of removable dentures, where the inner surface permanently touching oral cavity tissues, through to fixed dentures, and even some structures of certain implantological systems. all such items can be made of galvanized gold. thus, new technologies have made gold and its alloys a kind of a universal material.

gold is widely used in prosthetics. its use ranges from being employed in the fabrication of removable dentures, where the inner surface permanently touching oral cavity tissues, through to fixed dentures, and even some structures of certain implantological systems. all such items can be made of galvanized gold. thus, new technologies have made gold and its alloys a kind of a universal material. using metal alloys (gold alloys included) to make the framework for removable dentures is much better than using acrylic resin. this because the alloys have almost no destructive influence over the dentures bearing area. due to the precise way it is made, the stability of shape, the lack of internal stresses and the close contact with the dentures bearing area, it is possible to achieve very good retention of the denture over a long span of time. another advantage is that the metal framework conducts temperature changes and this facilitates keeping the tissues in good health. also, a denture metal framework makes it much easier for the patient to maintain good oral hygiene by lowering the risk of plaque accumulation. however, a metal framework has a disadvantage as well - prosthesis relining cannot be made.

Eligibility criteria:
inclusion criteria: 1. completely edentulous maxillary and mandibular ridges 2. healthy mucosa and absence of remaining roots 3. good physical and mental health 4. willing to give informed consent 5. normal maxilla-mandibular relationship angle class i 6. adequate bone quality and quantity in terms of width and height in the anterior maxillary mandibular ridges verified by preoperative cone beam ct 7. adequate inter-arch space to accommodate maxillary and mandibular implant prostheses exclusion criteria: 1. uncontrolled diabetes 2. smoking habits 3. radiotherapy 4. clinical or radiographic signs of pathologic conditions 5. osteoporosis 6. patients on corticosteroids 7. bruxism

Keywords: gold chrome denture mucosa
study of nasonex in the relief of nasal congestion in patients with seasonal allergic rhinitis (study p05528)(completed)

Conditions: Allergic Rhinitis

Summary: this study seeks to prospectively demonstrate that nasonex is better than placebo in relieving nasal congestion in patients with seasonal allergic rhinitis.


Eligibility criteria:
inclusion criteria: * a subject must be 12 years of age or older, of either sex, and of any race. * a subject must have at least a 2-year history of sar which exacerbates during the study season. * a subject must have a positive skin prick test response to an appropriate seasonal allergen at visit 1. * a subject must be clinically symptomatic at the screening and baseline visits. exclusion criteria: * a subject with a history of severe local reaction(s) or anaphylaxis to skin testing. * a subject who has had an upper respiratory tract or sinus infection that required antibiotic therapy without at least a 14-day washout prior to the screening visit, or who has had a viral upper respiratory infection within 7 days prior to the screening visit. * a subject who has used any drug in an investigational protocol in the 30 days prior to the screening visit. * a subject who is participating in any other clinical study. * a subject who is part of the staff personnel directly involved with this study. * a subject who is a family member (parent, spouse, or sibling) of the investigational study staff. * a female subject who is breast-feeding, pregnant, or intends to become pregnant. * a subject previously randomized into this study. * a subject who has a family member (parent, spouse, or sibling) currently enrolled in this study.
low-dose radiotherapy in treating painful bone metastases in patients with multiple myeloma

Conditions: Bone Pain; Metastatic Malignant Neoplasm in the Bone; Plasma Cell Myeloma

Summary: this phase ii trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. low-dose radiotherapy may be more convenient for patients and their families, may not interfere as much with the timing of chemotherapy, and may have less chance for short term or long-term side effects from the radiation.

primary objectives: i. to determine whether treatment with 2 gy x 2 to a painful myeloma bone lesion achieves patient-reported pain reduction comparable to current standard of care at 4 weeks. secondary objectives: i. to assess quality of life (qol) in patients treated with 2 gy x 2 to painful myeloma bone lesions. ii. to quantify analgesia use/reduction following 2 gy x 2 to a painful myeloma bone lesion. all opioid analgesia use will be converted into morphine equivalent in order to compare across the entire population. iii. to measure time to pain relief and duration of pain relief with 2 gy x 2. exploratory objectives: i. to record cytogenetics and international myeloma working group (imwg) response criteria at diagnosis and prior to and following radiotherapy (rt). outline: patients receive low-dose radiation therapy at consecutive business days 1 and 2 in the absence of disease progression or unacceptable toxicity. patients with no pain relief may receive additional radiotherapy at 4 weeks following initial radiotherapy. after completion of study treatment, patients are followed up at 2, 4, and 8 weeks and also at 6 months.

Eligibility criteria:
inclusion criteria: * histologic diagnosis of multiple myeloma * painful bone metastasis (index lesion) that has a radiographic correlate * patient may have had any number of prior chemotherapy/immunotherapy regimens (changes to systemic therapy or use of bisphosphonates for 4 weeks before and after rt are allowed, but recording of these changes must be made so it can be accounted for) * eastern cooperative oncology group (ecog) 0-2 * brief pain inventory (bpi) score \>= 2 * ability to understand and the willingness to sign a written informed consent exclusion criteria: * patients will be ineligible if the index lesion has received prior radiation therapy or prior palliative surgery. patients may have received prior palliative or primary radiotherapy or surgery to other parts of the body, as long as the index lesion was not in the prior radiation fields and has not received prior palliative surgery * patients will also be ineligible if there is pathologic fracture or impending fracture at the site of the index lesion or planned surgical fixation of the bone at the index lesion * patients with clinical or radiographic evidence of spinal cord or cauda equina compression/effacement from the index lesion, and/or with index lesions located at the skull base or orbital lesions * patients must not be pregnant
long-term safety and efficacy of kuc-7483 in patients with overactive bladder

Conditions: Overactive Bladder

Summary: to investigate the long-term safety, efficacy and pharmacokinetics of kuc-7483 in patients with overactive bladder.


Eligibility criteria:
inclusion criteria: * patients who have successfully completed the phase iii double-blind study. exclusion criteria: * patients with serious adverse events or clinically significant adverse events in the phase iii double-blind study.

Keywords: overactive bladder frequency micturition urgency urge urinary incontinence oab
study comparing the safety and efficacy of two doses of bc-3781 vs vancomycin in patients with acute bacterial skin and skin structure infection (absssi)

Conditions: Bacterial Infections; Infection

Summary: this is a phase ii, multi-center, randomized, double-blind study comparing the safety and efficacy of two doses of bc-3781 versus vancomycin in patients with acute bacterial skin and skin structure infection.

the purpose of the study is to determine the efficacy of 2 dose regimens of bc-3781 versus the licensed medicinal product vancomycin over 5 to 14 days. the population in this study will be patients with an acute bacterial skin and skin structure infection (absssi) and they will receive treatment with one of two doses of bc-3781 or vancomycin, a standard treatment for this condition.

Eligibility criteria:
inclusion criteria: * male or female patients \> 18 * documented acute bacterial skin and skin structure infection exclusion criteria: * uncomplicated skin and skin structure infection

Keywords: acute bacterial skin and skin structure infection bacteria
comparative analysis of the morpho-mechanical properties of red blood cells extracted from diabetic patients with and without microvascular complications

Conditions: Diabetes Mellitus, Type 1

Summary: the aim of the study is to analyse the biomechanical stiffness of red blood cells extracted from subjects with type i diabetes with and without microvascular complications through a biophysical characterization of red blood cells using microscopy, spectroscopy and scattering measurements. 48 subjects with type 1 diabetes, 24 with and 24 without microvascular complications will be enrolled. from all subjects a single blood sample will be taken to perform the analysis of red blood cells morpho-mechanical properties.


Eligibility criteria:
inclusion criteria: * diagnosis of type 1 diabetes for at least 10 years * stable metabolic control (hba1c \<7.5%) for at least 6 months * bmi between 18.5 and 30 kg/m\^2 * systolic blood pressure \< 140 mmhg and diastolic blood pressure \<90 mmhg exclusion criteria: * blood pressure higher than 140/90 mmhg * unstable metabolic control (hba1c \>7.5%) * bmi \> 30 kg/m\^2 or \< 18.5 kg/m\^2 * liver failure * concomitant acute infections * uncontrolled thyroid diseases * pregnancy
acute effects of beetroot juice ingestion on cognitive function and neuromuscular performance in elite female taekwondo athletes

Conditions: Dietary Supplements: Beetroot Juice Acute Supplementation; Dietary Supplement: Placebo Acute Supplementation

Summary: beetroot juice is a good source of nitrate (no3-), which is a precursor of nitric oxide (no) through the no3- to nitrite (no2-) to no pathway (lundberg et al., 2008). consequently, it is thought that a minimum threshold may exist for dietary no3- consumption of at least 5 mmol to enhance athletic performance (senefeld et al., 2020). in turn, systematic reviews have documented that the use of beetroot juice supplementation enhances muscle strength and power-related attributes (gonzalez et al., 2023), as well as performance in repeated high-intensity activity bouts (alsharif et al., 2023; dominguez et al., 2018). however, beetroot juice supplementation has been shown to have equivocal effects on neuromuscular performance specifically among individual sport athletes (e.g. taekwondo). thus, the aim of this study was to determine the effects of acute beetroot juice ingestion (140 ml, 12.8 mmol no3-) on neuromuscular performance in elite female taekwondo athletes.

beetroot juice is a good source of nitrate (no3-), which is a precursor of nitric oxide (no) through the no3- to nitrite (no2-) to no pathway (lundberg et al., 2008). this pathway is thought to promote increased sarcoplasmic reticulum calcium release and re-uptake with ensuing enhancements in force output within type ii muscle fibers (hernandez et al., 2012), as well as increased neurotransmitter release (esen et al., 2022) and attenuated muscle potassium efflux (wylie et al., 2013) that could benefit neuromuscular performance. consequently, it is thought that a minimum threshold may exist for dietary no3- consumption of at least 5 mmol to enhance athletic performance (senefeld et al., 2020). in turn, systematic reviews have documented that the use of beetroot juice supplementation enhances muscle strength and power-related attributes (gonzalez et al., 2023), as well as performance in repeated high-intensity activity bouts (alsharif et al., 2023; dominguez et al., 2018). however, beetroot juice supplementation has been shown to have equivocal effects on neuromuscular performance specifically among individual sport athletes (e.g. taekwondo). thus, the aim of this study was to determine the effects of acute beetroot juice ingestion (140 ml, 12.8 mmol no3-) on neuromuscular performance in elite female taekwondo athletes.

Eligibility criteria:
inclusion criteria: * age between 16 to 40 years * competed in international taekwondo competitions representing her national teams. * more than6 years of training experience (at least 3 sessions per week). * female taekwondo athletes. exclusion criteria: * male taekwondo athletes.

Keywords: nitrate nitrite neuromuscular taekwondo
preventive anti-inflammatory diet to reduce gastro-intestinal inflammation in fap patients: a prospective pilot study

Conditions: Familial Adenomatous Polyposis (FAP)

Summary: preventive anti-inflammatory diet to reduce gastro-intestinal inflammation in fap patients: a prospective pilot study

a prospective pilot study

Eligibility criteria:
inclusion criteria: - fap patients carrying mutations in apc gene, submitted to prophylactic total colectomy/ira (with rectum preservation) and that participate to the regular endoscopic surveillance program at irccs-int. exclusion criteria: * fap patients taking nsaids and/or omega 3 * patients who carried mutyh germline mutations or had no apc mutation found.

Keywords: fap familial adenomatous polyposis