Kornimate/medical-research-clean huggingface dataset:
relationship occupation and physical performance in elderly

Conditions: Old Age; Atrophy; Elderly; Occupational Balance; Postural Balance; Physical Performance

Summary: occupational competence indicates participating in a variety of occupations to meet the standards expected of the individuals' valued roles to sustain a pattern of occupational attitudes that is significant and satisfying. physical performance declines with age. this causes problems with balance and falling. balance and falling losses can also affect occupation. our study was conducted to examine the relationship between physical performance and occupational balance in elderly individuals. according to the power analysis, it is planned to include the individual in the study. individuals will only be evaluated and the relationship between scale results will be analyzed statistically.


Eligibility criteria:
inclusion criteria: * volunteers aged 65 and over will be included. exclusion criteria: * having visual-hearing loss that prevents them from making evaluations, * individuals with poor co-operation will be excluded from the study.
pathogenicity of b and cd4 t cell subsets in multiple sclerosis

Conditions: Multiple Sclerosis; Clinically Isolated Syndrome

Summary: the study aims at identifying the type of b and cd4 t cell subsets with pathogenic properties in the different clinical forms of multiple sclerosis. this research might open new therapeutic approaches for the treatment of multiple sclerosis particularly progressive ms.

multiple sclerosis (ms) is a chronic autoimmune disease damaging the central nervous system (cns). ms is categorized into several distinct forms according to clinical symptoms and medical examinations. relapsing-remitting multiple sclerosis (rrms) is characterized by attacks of worsening neurologic function, followed by partial or complete recovery periods. patients can also present a gradual but steady progression of the disease (progressive forms). while several treatment options are currently available, no treatment completely stops the disease progression. therefore, a deeper understanding regarding the mechanism of the disease development is essential to generate more efficient treatment strategies. cd4 t cells are known to be significantly involved in the formation of the cns lesions characteristic of ms.the investigators hypothesize that different types of b and cd4 t cells play major roles in different forms of the disease. they will determine the phenotype and functions of the cells from the immune system particularly b and cd4 t cells present in the blood and cerebro-spinal fluid (csf) of patients diagnosed with multiple sclerosis or presenting a clinically isolated syndrome. the study will recruit 150 patients followed in bordeaux university hospital and diagnosed for clinically isolated syndrome (cis) or multiple sclerosis (ms). blood and csf will be collected during a scheduled visit to study the properties of cells from the immune system in particular cd4 t cells in multiple sclerosis. clinical and biological disease activity, treatment and outcomes will be studied in correlation with the properties of blood and csf lymphocytes. no extra visit will be needed and the blood and csf samples will be collected at the same times as those collected for clinical purposes.

Eligibility criteria:
inclusion criteria: * male or female subjects ; * age ≥ 18 years; * subjects with ms defined by 2010 revised mcdonald criteria or presenting a clinical isolated syndrome; * patients for which a blood draw and / or lumbar puncture to collect csf is performed for diagnostic or therapeutic purpose; * affiliated to an health insurance system; * and who agree to participate in the study. exclusion criteria: * pregnant or breastfeeding women, * patient concerned by articles l 1121-5 to l 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent)

Keywords: autoimmune diseases of the nervous system multiple sclerosis clinically isolated syndrome lymphoid cells cd4 t cells b cells
phase iii safety and efficacy study to evaluate a glaucoma therapy in open-angle glaucoma or ocular hypertension patients

Conditions: Open-angle Glaucoma; Ocular Hypertension

Summary: the purpose of this study is to determine the safety and iop-lowering ability of a glaucoma therapy in patients with open-angle glaucoma or ocular hypertension


Eligibility criteria:
inclusion criteria: * adult subjects of either sex and any race 18 years or older with open-angle glaucoma or ocular hypertension. patients with logmar visual acuity not worse than 0.6 in either eye or any clinically relevant ophthalmic/systemic condition will be excluded. exclusion criteria: * see inclusion criteria
changes of ascending aortic diameter in patients undergoing transcatheter aortic valve replacement

Conditions: Aortic Stenosis; Ascending Aortic Dilatation; Bicuspid Aortic Valve

Summary: the goal of this observational study is to assess the changes of ascending aortic diameter in patients undergoing transcatheter aortic valve replacement. the main questions it aims to answer are: 1. whether the ascending aortic diameter increases or remains stable after transcatheter aortic valve replacement, especially in patients with preoperative ascending aortic dilatation; 2. the determinants of postoperative ascending aortic dilatation.

ascending aortic (aa) dilatation occurs frequently in patients with aortic stenosis (as). for patients who are candidates for transcatheter aortic valve replacement (tavr), simultaneous repair of a dilatated aa is technically difficult. as the indications for tavr have extended to low-risk patients and patients with bicuspid aortic valve , aa dilatation should be considered as a new criterion to refine risk stratification in patients undergoing tavr. in this observational study, we aim to evaluate the changes of aa diameters and identify the determinants post-tavr aa dilatation.

Eligibility criteria:
inclusion criteria: * severe aortic stenosis defined as an aortic valve area of 1cm2 or less or an indexed aortic valve area of 0.6cm2/m2 or less; * presence of clinical symptoms defined as a new york heart association functional class of 2 or more; * high risk of surgical aortic valve replacement; * suitability for a transfemoral vascular access. exclusion criteria: * dominant aortic regurgitation; * history of surgical or transcatheter aortic valve replacement; * history of aortic surgery; * connective tissue disorders.

Keywords: transcatheter aortic valve replacement ascending aortic diameter ascending aortic dilatation bicuspid aortic valve
efficacy study of methylphenidate hydrochloride to reduce fatigue in prostate cancer patients receiving hormone therapy

Conditions: Prostatic Neoplasms; Fatigue

Summary: the purpose of this study is to determine if methylphenidate improves fatigue in men undergoing hormonal therapy for prostate cancer with an lhrh-agonist.

this study will determine if methylphenidate improves fatigue in men undergoing hormonal therapy for prostate cancer. fatigue is a common problem experienced by cancer patients. those patients who are receiving chemotherapy or radiation are especially vulnerable to fatigue, as are men with prostate cancer who are receiving hormonal therapy with an lhrh-agonist (androgen deprivation therapy). eligible men will be randomized to a daily dose of 10 mg methylphenidate or placebo for a total treatment period of 12 weeks. subjects will be monitored for changes in fatigue and mood during this period. while the exact cause of fatigue in this setting is unknown, this study will hopefully lead to a better understanding of the process and provide patients with a much-needed remedy for fatigue

Eligibility criteria:
inclusion: * age \> 18 and ≤ 85 years * histologically confirmed prostate cancer * currently receiving lhrh-agonist therapy for greater than 6 months with measurable fatigue, defined as a score of \>1 on the bruera global fatigue severity scale or * deemed eligible to commence lhrh-agonist therapy, with confirmation of fatigue at screening visit 2 * have a serum psa which is stable or decreasing based on the psa trend over the last 2 values taken at least 2 months apart, with the more recent value taken at least 2 months after initiation of lhrh-agonist therapy. * have adequate liver and renal function (bilirubin ≤ 1.5 x uln and ast, alt and serum creatinine \< 2 x uln) * able to swallow and retain oral medication * life expectancy of at least 1 year * able to read and write in english (and therefore accurately complete the required study questionnaires), understand instructions related to study procedures and give written informed consent. exclusion: * current malignancy or received treatment for a previous malignancy within the last 3 years other than prostate cancer (other exceptions are superficial bladder cancer or non-melanoma skin cancer) * previous chemotherapy within the last 5 years * anemia (hemoglobin \< 100 g/l) * myocardial infarction within past 6 months * any unstable serious co-existing medical condition(s) including but not limited to ; unstable or poorly controlled coronary artery disease, chronic atrial fibrillation, uncontrolled hypertension, uncontrolled diabetes, severe bleeding diseases or immune disorders * severe depression as defined by ces-d score \>27 * history of motor tics, seizures or a family history of tourette's syndrome * infection with hiv (human immunodeficiency virus), hbv (hepatitis b) or hcv (hepatitis c) * evidence of drug or alcohol abuse * known hypersensitivity to methylphenidate * possess any other contraindications to methylphenidate use

Keywords: lhrh-agonist related fatigue
role of inflammation in progressive multifocal leukoencephalopathy (pml)

Conditions: Progressive Multifocal Leukoencephalopathy

Summary: this is a continuation of our previous studies on progressive multifocal leukoencephalopathy (pml). we will focus on the role of inflammation in pml, and define prognostic markers of disease evolution.

to determine precisely what are the host or viral factors that may predict a favorable outcome for pml patients and the role of inflammation in preventing jcv from causing brain disease. one of the goals of this study is to help establish non-invasive markers of pml evolution by studying the brain metabolism in pml lesions using magnetic resonance imaging (mri), magnetic spectroscopy (mrs) and other advanced imaging modalities.

Eligibility criteria:
inclusion criteria: * pml patients of 18 years of age or older will be included in this study. exclusion criteria: 1. presence of opportunistic brain lesions other than pml. ( e.g., toxoplasmosis, lymphoma) 2. presence of confounding neurological disorder such as brain neoplasm etc. in addition patients with a contraindication to mri examination will be excluded from study. contraindications to the mri examination include: 1. medically unstable or hematological, renal, or hepatic dysfunction. 2. cardiac pacemaker 3. internal clips, 4. metal implants, or external clips with 10 mm of the head. 5. metal in the eyes. 6. pregnant 7. claustrophobia

Keywords: jc virus
aromatic amino acid metabolism in the pathogenesis of kwashiorkor

Conditions: Kwashiorkor

Summary: this research may explain whether a shortage of three special compounds called aromatic amino acids is responsible for the severe illness and high death rate of children with the kwashiorkor type of malnutrition and whether supplying adequate amounts of these compounds in the treatment diet will speed up recovery from this condition. we propose that decreased availability of the aromatic amino acids may be the reason why children with kwashiorkor are sicker and more difficult to treat.


Eligibility criteria:
inclusion criteria: * malnourished children between 6 to 18 months of age. * to standardize for degree of malnutrition, only patients whose weight is \< 80 % of that expected for age will be enrolled. by the wellcome classification (22), enrolled patients will have marasmus (\< 60 % weight/age and no edema), marasmic-kwashiorkor (\< 60 % weight/age plus edema) or kwashiorkor (\< 80 % weight/age plus edema). * presence of infection at admission. infection will be defined by the presence of two or more of the following: leukocyte count \>11,000 cells/dl, temperature at admission \> 99 of, positive blood or urine cultures. exclusion criteria: * criteria for exclusion will include presence of cardiovascular, hepatic, renal, gastrointestinal, metabolic disease or hiv/aids.
blood-based identification and monitoring of patients with alk-translocated lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: genetic rearrangements in the anaplastic lymphoma kinase (alk) gene result in the creation of a variety of oncogenic fusion proteins that drive malignancy in a subset of non-small cell lung cancers (nsclc) patients. treatment with the alk small tyrosine kinase inhibitor (tki) crizotinib has produced remarkable results for alk-positive patients, however the current diagnostic tests used in the clinic are not sufficiently detailed and require a tumor biopsy. the aim of this study is to use a new diagnostic test to detect alk rearrangements using next generation sequencing, which will improve the diagnosis and treatment of alk-positive nsclc patients. furthermore, this test will be performed on blood samples, making it minimally invasive for the patients. it is our believe that circulating tumor dna (ctdna) in blood can be employed as an easy accessible and comprehensive source of information to diagnose alk-positive disease, but also as a means of monitoring patient response during treatment. quantitation of the the amount of alk rearrangement will give information about which patients benefit from treatment and when treatment is no longer effective. the project will be a multicenter study where blood samples will be collected every 6 weeks from patients treated at four major hospitals in denmark. this study will benefit future patients with lung cancer, as it will improve both the monitoring and evaluation of their treatment. monitoring patients during treatment will provide more knowledge of disease progression and the effect of alk-tki treatment, contributing to a greater selection of patients, who will respond to treatment. this will potentially allow effective treatment to continue longer than with conventional methods


Eligibility criteria:
inclusion criteria: * non-small cell lung cancer diagnosis * biopsy-verified alk-translocation exclusion criteria: * patients were it is not possible to retrieve a biopsy * patients with squamous cell carcinoma

Keywords: alk rearrangement circulating tumor dna plasma dna non-small cell lung cancer tyrosine kinase inhibitors
cbt4cbt for women in residential treatment for substance use disorders

Conditions: Substance Use Disorders; Drug Abuse; Drug Addiction; Substance Abuse; Drug Use Disorders; Drug Dependence; Substance Addiction

Summary: this project examines computer-delivered cognitive-behavioral intervention (cbt4cbt) as an adjunct to residential treatment for women with substance use disorders (sud). the project will conduct a 2-arm randomized clinical trial (rct) comparing post-discharge relapse rates for treatment as usual (tau) with access to the cbt4cbt program vs. tau in a residential sample of women with suds.

women with substance use disorders face unique barriers to substance use treatment, and as a result, are less likely to seek treatment for substance use than their male counterparts. women's residential treatment settings have been shown to have higher rates of treatment completion and better outcomes; however, relapse rates for substance use are high, with estimates ranging from 40-60%. cognitive behavioral therapy (cbt) has been identified as an evidence-based treatment known to improve relapse rates by teaching clients how to recognize and respond to their cues for substance use. women may particularly benefit from cbt, as their relapse risk factors include depression, interpersonal stress, and relationship conflict. despite the effectiveness of cbt, its dissemination is hindered due to limited availability of trained clinicians, cost, and limited resources. computer-based training for cognitive behavioral therapy (cbt4cbt) offers an opportunity to improve the quality and reach of treatment services that is both feasible and cost-effective. studies to date have demonstrated the utility of cbt4cbt in outpatient settings; however, it has not yet been evaluated as an adjunct to residential treatment for suds. the specific aims are to: 1) examine feasibility for use of cbt4cbt in a residential treatment program for women with suds; 2) conduct a small rct comparing tau with access to the cbt4cbt program (cbt4cbt; intervention) vs. treatment as usual (tau; control) using relapse rates and days of use as primary treatment outcomes; 3) exploratory analyses will identify other correlates (e.g., coping strategies, depression) of relapse at 4 and 12 weeks post-discharge.

Eligibility criteria:
inclusion criteria: * ≥18 years of age * female * meet dsm-5 criteria for a sud (current) * own a smartphone * can return to facility for the 4 and 12-week follow-up visits. exclusion criteria: * pregnant * cognitive or psychiatric impairment * language barriers that preclude informed consent
machine learning ventilator decision system vs. standard controlled ventilation

Conditions: Mechanical Ventilation; Critically Ill Patients

Summary: ventilator-induced lung injury is associated with increased morbidity and mortality. despite intense efforts in basic and clinical research, an individualized ventilation strategy for critically ill patients remains a major challenge. however, an individualized mechanical ventilation approach remains a challenging task: a multitude of factors, e.g., lab values, vitals, comorbidities, disease progression, and other clinical data must be taken into consideration when choosing a patient's specific optimal ventilation regime. the aim of this work was to evaluate the machine learning ventilator decision system, which is able to suggest a dynamically optimized mechanical ventilation regime for critically-ill patients. compare with standard controlled ventilation, to test whether the clinical application of the machine learning ventilator decision system reduces mechanical ventilation time and mortality.


Eligibility criteria:
inclusion criteria: 1. only the first icu stay was eligible; 2. adults ≥ 18 years of age on icu admission; 3. estimate mechanical ventilation time ≥24 hours;
shuttle walk test performed on a treadmill versus a corridor in patients with copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: it is still not clearly known whether doing the walk test in a course is different from doing it on a treadmill in the lack of a ten-meter-long corridor. in case of a positive outcome in this study, we will have an alternative for this test in places where there is not enough room, benefiting the assessment of copd patients' functional capacity. in the literature, there are still some controversies about performing the test on a treadmill or in a corridor and whether there is interference with the distance walked. our hypothesis is that there is no interference with the distance walked, and thus we have one more option to perform the test in case there is no 10-meter corridor available.

spirometry tests will be performed using ultima cpx equipment. volunteers will perform the tests twice, on different days (see protocol description), in a corridor and on a treadmill, until reaching their limit of tolerance. in the test performed on the treadmill and in the one performed in the corridor, subjects will simultaneously use the vo 2000. and the volunteers will fill out the saint george's respiratory questionnaire (sgrq).

Eligibility criteria:
inclusion criteria: * clinically stable * not dependent on oxygen to exercise * diagnosis of copd according to the gold exclusion criteria: * cognitive deficit or musculoskeletal * in process of exacerbation * have performed pulmonary rehabilitation

Keywords: copd swti treadmill
evaluation of cavernous sinus invasion by pituitary adenoma using deep learning based denoising mr

Conditions: Cavernous Sinus Invasion by Pituitary Adenoma

Summary: preoperative evaluation of cavernous sinus invasion by pituitary adenoma is critical for performing safe operation and deciding on surgical extent as well as for treatment success. because of the small size of the pituitary gland and sellar fossa, determining the exact relationship between the pituitary adenoma and cavernous sinus can be challenging. performing thin slice thickness mri may be beneficial but is inevitably associated with increased noise level. by applying deep learning based denoising algorithm, diagnosis of cavernous sinus invasion by pituitary adenoma may be improved.


Eligibility criteria:
inclusion criteria: * patients undergoing preoperative brain mr for pituitary adenoma exclusion criteria: * patients who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulates, electronic infusion pumps, etc), because such devices may be displaced or malfunction * patients who are pregnant or breast feeding; urine pregnancy test will be performed on women of child bearing potential * poor mri image quality due to artifacts