Kornimate/medical-research-clean huggingface dataset:
crush study: calculating readmission risk by ultrasound for heart failure failure study

Conditions: Heart Failure

Summary: this is a study to determine if two ultrasound measures (corrected flow time and b-lines) can predict patients at higher risk of readmission within 30 days of hospital discharge for decompensated heart failure.

heart failure (hf) resulting in congestion is the leading cause for admission in persons ≥65 years of age and 20-25% of such patients are readmitted within 30 days of discharge. efforts to treat hf are difficult without a simple method to detect early signs of congestion to direct therapy. ultrasound can detect evidence of congestion by increased cardiac filling pressures two weeks prior to other markers of congestion such as weight gain or patient symptoms. corrected flow time (ftc) measured by ultrasound, is an easy to perform vascular measure and correlates with cardiac filling pressures. despite the relationship between ftc and filling pressures, this measure has never been studied in hf. the primary aim is to determine if ftc can predict patients at risk of readmission within 30 days. as a secondary aim, the investigators plan to validate a small study of patients reporting the ability of pulmonary ultrasound to predict readmissions. this study demonstrated pulmonary ultrasound was 100% sensitive and 68% specific for predicting readmission at 3 months, however this investigation was small and validation is needed. it is expected ultrasound will be able to accurately and safely predict patients who will be readmitted within 30 days of discharge. this proposal is aimed at identifying a noninvasive measure to better assess congestion from hf and predict readmissions.

Eligibility criteria:
inclusion criteria: * english speaking * being admitted for heart failure with expected hospital stay of 72 hours exclusion criteria: * unable to provide consent
effect of virtual reality on patient's comfort during cardiac electronic device implantation.

Conditions: Virtual Reality; Medical Device; Local Anesthesia; Pain

Summary: the purpose of this study is to assess the effect on patient's comfort of a virtual reality experience during a procedure of cardiac electronic device implantation under local anesthesia.


Eligibility criteria:
inclusion criteria: * patients over 18 year old, * patients who signed the consent form and accepted to participate to the trial, * new cardiac electronic device implantation or cardiac electronic device battery change, * surgical procedure planned in ambulatory care. exclusion criteria: * communication limitations, * surgical procedure planned in sedation or narcosis, * severe sensorial deficits (visual, auditory), * claustrophobia, * known motion sickness, * patient isolated or with contact precautions, * known or anticipated psychiatric diseases, * patient known for epilepsia, * opened scar and or ongoing infection at the level of the face and/or eyes, * patient evaluated non suitable for the study by the surgeon, cardiologist or anesthetist.
head-to-head comparison between [18f]-fdg pet/ct and pet/mri in lymphomas

Conditions: PET/MRI

Summary: investigating the performance of 18f-fdg pet/ct and pet/mri in lymphomas

in this study investigators evaluated nodal and extranodal lymphoma lesions uptake by 18f-fdg pet (pet/ct and pet/mr). prior to treatment, all patients will undergo whole-body 18f-fdg pet/ct and pet/mr. the methods' efficiency was compared in the diagnosis of lymph node (ln) and organ involvement.

Eligibility criteria:
inclusion criteria: * pathologically diagnosed as lymphoma; written informed consent for receiving pet/mri after pet/ct examinations. cancer planned chemotherapy or immunotherapy scheme. expected survival ≥ 12 weeks exclusion criteria: * cannot lie supine for half an hour; refuse to join the clinical researcher; severe liver or kidney dysfunction pregnancy or lactation

Keywords: positron-emission tomography lymphoma
character strengths intervention among psychiatrically hospitalized youth

Conditions: Psychiatric Hospitalization; Mental Disorders; Child/Adolescent Problems

Summary: research has shown that identifying and using one's character strengths in new ways decreases depressive symptoms and increases happiness in adults in the general population. recently, we found that a similar intervention increases the self-esteem and self-efficacy of children and adolescents being treated in an inpatient psychiatric unit. the purpose of this study is to better understand the effects that discovering one's character strengths and incorporating them into coping skills will have on treatment outcomes in patients admitted to a child and adolescent inpatient psychiatric unit.

the primary aim of this study is to investigate whether a character strengths-based intervention results in significant improvements in measures of depression, anxiety, resiliency, optimism, self-perception, and life-satisfaction of psychiatrically hospitalized youth up to three months following admission. secondary aims are to: (1) examine participants' strengths profile to identify potential correlates between character strengths, psychiatric diagnoses and intervention effectiveness; and (2) determine whether patients who continue to incorporate their strengths into coping skills at follow-up assessments exhibit greater improvement over-time. participants will be 210 adolescents aged 12 to 17 years admitted to the child and adolescent psychiatric inpatient program and will be randomized into one of the three groups. all participants will complete the values in action inventory of strengths for youth (via-youth) survey on their second hospital day and subsequently receive the signature strengths intervention (experimental group), coping skills with memory aids comparison exercise (positive control group), or coping skills without memory aids (treatment-as-usual control group). outcome measures will be completed by all participants at baseline (day 1 on unit), post-treatment (day 4 on unit), and 1- and 3-months following admission. the proposed research represents a change in paradigm, as we aim to specifically examine the therapeutic benefit of the positive psychology element of our intervention conducted in the pilot study among youth with severe mental illness.

Eligibility criteria:
inclusion criteria: * patient on child and adolescent psychiatric unit exclusion criteria: * cognitive disability or severe psychosis preventing understanding of survey measures * prior use of via-youth survey * absence of legal guardian to consent
epidemiological characteristics and treatment protocol for carbapenem-resistant klebsiella pneumoniae in china

Conditions: Klebsiella Pneumoniae Infection

Summary: klebsiella pneumoniae is one of the most common pathogens causing nosocomial infection. recently, the emergency of carbapenem-resistant klebsiella pneumoniae (crkp) had cause the clinical therapy be very difficult. however, there is not much empirical data as to the prevalence, risk factors, characteristics, and the rationality of the current therapy for the crkp infection. thus, the study was aimed to investigate the epidemiology and risk factors, characteristics, and the rationality of the current therapy for the crkp infection.

all the patients with culture positive of klebsiella pneumoniae were screened and reported to the the clinical doctors and confirmed by them. and the clinical characteristics of the patiens, such as baseline data, outcomes etc, were recorded. finially, to find the prevalence, risk factors, characteristics, and the rationality of the current therapy for the crkp infection

Eligibility criteria:
inclusion criteria: * new confirmed noscomial infection of crkp exclusion criteria: * age\ 85 years old; mixed infection of crkp and other microbes
postpartum thyroid measures and mood

Conditions: Postpartum Depression

Summary: women with abnormal serum thyroid antibody levels or abnormal tsh and/or t4 values are more likely than their normal counterparts to have higher scores on a common postpartum depression screening test.

this small pilot study was an attempt to corroborate a relationship between quantified mood and thyroid measures, using the numerical scores obtained from a common depression screen, the edinburgh postnatal depression scale (epds), as a continuum. mood scores were compared with presence of thyroid autoantibodies and plasma concentrations of free t4 and tsh.

Eligibility criteria:
inclusion criteria: * over 18 years of age * in third trimester of pregnancy when recruited * negative for the following drugs detected by a urine drug screen: * amphetamines * barbiturates * benzodiazepines * cocaine * opiates * phencyclidine metabolites (pcp), and tricyclic antidepressants * vaginal delivery * screened negative for major depressive disorder on the edinburgh postnatal depression scale (epds) at her prenatal enrollment in the study * receiving a score of 12 or lower out of a possible 30 exclusion criteria: * under age 18 * positive for any of the following drugs: * amphetamines * barbiturates * benzodiazepines * cocaine * opiates * phencyclidine metabolites (pcp), and tricyclic antidepressants * cesarean delivery * epds score over 12 at prenatal screening test

Keywords: postpartum depression thyroxine thyroid antibodies thyroid stimulating hormone edinburgh postnatal depression scale (epds)
study to determine a preference between sildenafil or tadalafil treatment for problems getting an erection

Conditions: Impotence

Summary: to determine if men with problems getting and keeping an erection prefer treatment with tadalafil or sildenafil.


Eligibility criteria:
inclusion criteria: * history of erection problems * anticipate a monogamous female sexual relationship * abstain from other erection treatments throughout the study * currently use sildenafil exclusion criteria: * other primary sexual disorders * history of radical prostatectomy or other pelvic surgery that affected being able to have an erection * history of penile implant or clinically significant penile deformity. * nitrate use * certain heart problems
effectiveness of eras on postoperative recovery after minimally invasive gastrectomy

Conditions: Enhanced Recovery After Surgery; Gastrectomy for Gastric Cancer

Summary: this prospective, randomized, open-label, multicenter study is designed to evaluate the impact of an enhanced recovery after surgery (eras) protocol on the rate of meeting discharge criteria in patients undergoing minimally-invasive gastrectomy for gastric cancer. we hypothesize that implementation of our eras protocol will significantly increase the proportion of patients who meet standardized discharge criteria following minimally-invasive gastrectomy.

adult patients undergoing elective minimally invasive gastrectomy were randomly allocated to receive either the eras protocol (n = 154) or the conventional protocol (n = 154). the conventional group received the current standard perioperative care at our institution, whereas the eras group received a newly developed eras protocol, which included preoperative carbohydrate loading, reduced perioperative fasting duration, and multimodal opioid-sparing analgesia. the primary outcome was the proportion of patients who met standardized discharge criteria at 9:00 am on postoperative day 4. secondary outcomes included the eq-5d-5l index assessed at 24, 48, 72, and 96 hours postoperatively; pain intensity at rest and during coughing measured using an 11-point numeric rating scale at 2, 24, 48, and 72 hours postoperatively; gastrointestinal dysfunction assessed using the i-feed score at 24, 48, and 72 hours postoperatively; the incidence of postoperative nausea and vomiting within 0-24, 24-48, and 48-72 hours after surgery; the incidence of major postoperative complications classified by the clavien-dindo grading system during hospitalization; and postoperative length of hospital stay.

Eligibility criteria:
inclusion criteria: * adults aged ≥19 years scheduled to undergo elective laparoscopic or robotic gastrectomy for gastric cancer * american society of anesthesiologists physical status classification i to iii * ability to provide written informed consent, demonstrate understanding of the study protocol, and complete patient-reported outcome measures appropriately exclusion criteria: * requirement for resection of organs other than the stomach during surgery (except for cholecystectomy) * history of upper abdominal surgery (except for cholecystectomy) * known hypersensitivity to fentanyl, ropivacaine, acetaminophen, or non-steroidal anti-inflammatory drugs * determined by the investigator or study personnel to be otherwise unsuitable for participation in the study

Keywords: enhanced recovery after surgery stomach neoplasms gastrectomy for gastric cancer pain, postoperative
direct versus indirect pick up of the locator retentive caps:(within-patient study)

Conditions: Prosthesis Durability

Summary: the purpose of this study will be to evaluate the effect of direct and indirect pick up of the locator retentive caps and compare the clinical results with those of the manufacturer retentive force.

patient selection: for this study, 30 patients were selected from the clinic of prosthodontic department, faculty of dentistry, mansoura university. according to pick up technique for the locator retentive caps, the overdentures will be classified into two groups as follows; group1: the retentive caps will be picked up by indirect method on the cast then by the direct method group2: the retentive caps will be picked up in the patient by the direct method first then by the indirect method. for both groups, the clinical retention will be measured after using pink and blue retentive inserts respectively. all implants were inserted using computer-guided implant surgery and conventional loading protocol was used. evaluation methods the clinical retention of each insert will be calibrated as regards the manufacturer's value. also, the laboratory retention will be assessed for the two groups and calibrated as regards the manufacturer's value. measurements will be done immediately, three and six months after each overdenture insertion.

Eligibility criteria:
inclusion criteria: * ● free from any systemic disease that may interfere with the osseointegration of implants. * patients will have completely edentulous maxilla and mandible for at least 6 months after the last extraction. * patients will have normal maxilla mandibular relationships. * mandibular arch with residual alveolar ridges covered with firmly attached mucosa. * the width of the mandibular ridge in the canine area will be sufficient for the installation of the implants in parallel anteroposterior and mesiodistal directions. exclusion criteria: * medically compromised patients smokers uncontrolled metabolic diseases ( diabetes mellitus ) uncooperative patients
pep and opep devices in cystic fibrosis

Conditions: Cystic Fibrosis

Summary: cystic fibrosis (cf) is the most common severe autosomal recessive genetic disease in caucasians. the cftr (cystic fibrosis transmembrane regulator) gene, which encodes the chloride channel of the epithelial cell membrane, is responsible for the development of the disease. respiratory physiotherapy, especially bronchial drainage is one of the basic elements of comprehensive management in patients with cf. among the many procedures used in cf drainage physiotherapy, the most commonly include these using positive expiratory pressure (pep) and oscillating positive expiratory pressure (opep). the aim of the study is to assess the efficacy of the usage of selected pep and opep devices in bronchial drainage in cystic fibrosis patients during exacerbation of the disease.

the aim of the study is to assess the efficacy of the short-term (4-days) use of selected devices generating positive expiratory pressure (pep device: pari pep® s system) and oscillating positive expiratory pressure (opep devices: aerobika\* opep device and pari o-pep device commonly called: flutter) in bronchial drainage in cystic fibrosis patients during exacerbation of the disease. patients will perform bronchial drainage in three different groups using different devices in each of them. the main questions study aims to answer are: 1. whether the devices used are effective in bronchial drainage in patients with cystic fibrosis, 2. are there differences in efficiency between the devices used.

Eligibility criteria:
inclusion criteria: * written consent of the patient and/or guardian, age over 12, no disease complications (within the last 2 months) in the form of: active haemoptysis, pneumothorax, chest surgeries, surgical procedures in the area of the esophagus (esophageal varices), otitis media, * the ability to perform correctly lung function tests and fev1 value above 20% predicted, * the presence of respiratory symptoms indicating exacerbation of the disease, i.e. increasing of cough, increasing of dyspnoea, decrease in fev1 by 10% or more from a previously recorded value. exclusion criteria: * lack of written consent of the patient and/or guardian, age below 12, occurrence of disease complications (within the last 2 months) in the form of: active hemoptysis, pneumothorax, chest surgeries, surgical procedures in the area of the esophagus (esophageal varices), otitis media, * inability to perform lung function tests, fev1 value below 20% of predicted value, * pep, opep device intolerance, * no symptoms of the respiratory system indicating exacerbation of the disease, i.e. increasing of cough, increasing of dyspnoea, decrease in in fev1 less than 10% from a previously recorded value.

Keywords: cystic fibrosis pep opep
efficacy and safety of shr3824 as monotherapy in subjects with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to obtain information on efficacy and safety of shr3824 over 24 weeks and 52 weeks in chinese patients with type 2 diabetes. this will be done by comparing the effect of shr3824 to placebo when given in oral doses.


Eligibility criteria:
inclusion criteria: * patients must have a diagnosis of type 2 diabetes mellitus; * patient either has not been previously treated with antihyperglycemic medication or has not been treated with antihyperglycemic in the last 8 weeks; * fpg\<=15mmol/l; * hemoglobin a1c levels \>=7.0% and \<=10.5%; * body mass index (bmi) 19 to 35 kg/m2; exclusion criteria: * type i diabetes mellitus, diabetes mellitus resulting from pancreatic disorder, or secondary diabetes mellitus (acromegaly, cushing's syndrome, etc.); * past or current history of severe diabetic complications (proliferative diabetic retinopathy, stage iii or later stage overt nephropathy, diabetic ketoacidosis, or serious diabetic neuropathy); * systolic blood pressure of ≥160 mmhg or diastolic blood pressure of ≥100 mmhg on the start or end day of the run-in period; * history of myocardial infarction, unstable angina, or cerebrovascular disorder within 6 months before the start of the run-in period; * past or current history of malignant tumor; * past or current history of drug hypersensitivity such as shock and anaphylactoid symptoms; * pregnant women, lactating mothers, or women of childbearing potential; * any condition that subjects are assessed to be ineligible by the investigator (sub investigator).
supporting laypeople addressing prehospital hemorrhage study

Conditions: Hemorrhage; Laceration

Summary: it is unknown if bystanders equipped with point-of-care (poc) instruction are as effective as bystanders with in-person training for bleeding control. therefore, poc instructional interventions were developed during this study in response to the scalability challenges associated with in-person training to measure the comparative effectiveness and skill retention of poc instructions vs in-person training using a randomized clinical trial design.

road traffic injuries (rtis) are the largest contributor to the global trauma burden, which disproportionately affects low- and middle-income countries (lmics). with a lack of robust emergency medical services (ems), there has been increasing reliance on layperson bystanders to respond to rtis in lmics, called lay first responders (lfrs). in prospective studies of lfr activity across three sub-saharan african countries comprising 2,039 total patient encounters, lfrs most frequently provided hemorrhage control in 61% of patient encounters. rapid hemorrhage control for compressible extremity hemorrhage by bystander lfrs has the potential to mitigate exsanguination, reducing mortality secondary to rtis. rapid hemorrhage control also has applicability to high-income country settings like the united states that sustain high rates of penetrating trauma due to gun violence. rapid hemorrhage control using tourniquets for compressible extremity hemorrhage in patients not yet in shock is strongly associated with saved lives demonstrated in battlefield studies, decreasing preventable deaths by more than 50%. bystanders may be trained in-person or point-of-care (poc) instruction may be provided, as exists with automated external defibrillators. however, it is unknown if bystanders equipped with poc instruction are as effective as bystanders with in-person training for tourniquet application. therefore, the investigators developed poc instructional interventions in response to the scalability challenges associated with in-person training to measure comparative effectiveness and skill retention using a randomized controlled trial design.

Eligibility criteria:
inclusion criteria: * understand spoken and written english exclusion criteria: * none
study of pain following removal of wisdom teeth with acute pulpitis

Conditions: Pain

Summary: the purpose of this study is to determine whether pulp chamber opening and drainage on wisdom teeth with acute pulpitis before the extraction could reduce postoperative pain so beneficial to patient.


Eligibility criteria:
inclusion criteria: * inclusion criteria of upper wisdom teeth for the two groups were: vertical eruption; being worthless to be restored; deep caries in the occlusion surface with acute pain; without caries or acute pulpitis in the adjacent second molar exclusion criteria: * systemic diseases, smokers, inflammation in oral cavity,with history of psychiatric illness,pregnant or lactating females

Keywords: wisdom teeth acute pulpitis extraction pain pain following removal of wisdom teeth with acute pulpitis
lateral epicondylitis treatment high intensive laser therapy and extracorporeal shock wave therapy

Conditions: Lateral Epicondylitis

Summary: objectives: this study aims to evaluate and compare the short-term efficacy of high-intensity laser therapy (hilt) and extra corporeal shock wave therapy(eswt) on pain, sensitivity, handgrip strength, and functions in the treatment of lateral epicondylitis (le). material and methods: forty five participants (age range, 18 to 65 years) with unilateral elbow pain were randomized into two groups. hilt group (n = 22) and the eswt group (n = 23). the hilt and eswt were administered three times a week for three weeks, and each treatment was combined with exercises. all patients in both groups were evaluated with ultrasonography for common extensor tendon(cet) thickness. a visual analog scale (vas), quick disabilities of the arm, shoulder, and hand (qdash), and hand grip strength test were used to evaluate the patients before, one, and six weeks after treatment.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of lateral epicondylitis * age \>18 exclusion criteria: * operation history about elbow * received physical therapy, or had a steroid injection to the elbow in the three months * cervical radiculopathy, * elbow deformities, * fibromyalgia syndrome, * carpal tunnel syndrome, * neurological impairments in the upper extremity, * chronic inflammatory conditions, * hemophilia, * pregnant, * history of malignancy

Keywords: lateral epicondylitis high intensive laser therapy extracorporeal shock wave therapy musculoskeletal ultrasound