Kornimate/medical-research-clean huggingface dataset:
study to evaluate the effect of megestrol acetate in severe chronic obstructive pulmonary disease with loss of weight

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of this trial is to study the effect of megestrol acetate in the gain of body weight in patients with severe chronic obstructive pulmonary disease in order to improve the survival of the patients.

it has been demonstrated that the body weight measured as a body mass index (bmi)is an independent risk factor of mortality in the severe copd.it seems to be one influence of inflammatory factors in the development of denutrition in these patients. the use of especial diets has no so good results in the aim to improve the weight, being necessary to complement with muscular rehabilitation or anabolic products. the megestrol acetate has demonstrated good results in a short period of time, nevertheless the studies are scarce. the beneficial effects of the megestrol acetate seems to be mediated by cytokines.

Eligibility criteria:
inclusion criteria: * clinical diagnose of copd (criteria ats/ers 2004) * clinical stability more than 3 months * smokers or ex-smokers of more than \> 10 boxes/year than do not modify their smoking habit during the study. * fev1 (post-bronchodilator) \< 50%. fev1/fvc ≤ 70 * negative answer to bronchodilator(≤ 20% del fev1 o ≤ 200 ml.after 400 mcg.de salbutamol inhaled) * bmi \< 21 kg/m2 ó bmi 21-25 kg/m with loss weight of 5% of the habitual body weight in the last 3 months, without other reason that could explain it independently of the copd. exclusion criteria: * use of nasogastric catheter * concomitant treatment with steroid, anabolics or other progestagens. * loss of body weight related with other causes: hyperthyroidism, enteral malnutrition ( crohn disease...), neoplasias,etc * treatment with megestrol acetate in the last 6 months

Keywords: copd body weight megestrol acetate cytokines
a study to evaluate efficacy and safety of vx-150 in subjects with acute pain following bunionectomy

Conditions: Acute Pain

Summary: this is a phase 2 randomized, double-blind, placebo-controlled, 3-arm, parallel design study to evaluate the efficacy and safety of vx-150 in treating acute pain following bunionectomy.


Eligibility criteria:
inclusion criteria: prior to surgery: * body mass index (bmi) of 18.0 to 38.0 kg/m2, inclusive * be scheduled to undergo a primary unilateral first metatarsal bunionectomy repair, without collateral procedures, under regional anesthesia (mayo and popliteal sciatic block) not to include base wedge procedure after surgery: * subject reported pain of ≥4 on the nprs, and moderate or severe pain on the verbal categorical rating scale (vrs) within 9 hours after removal of the popliteal sciatic block on day 1 * subject is lucid and able to follow commands * all analgesic guidelines were followed during and after the bunionectomy exclusion criteria: prior to surgery: * history in the past 10 years of malignancy, except for squamous cell skin cancer, basal cell skin cancer, and stage 0 cervical carcinoma in situ * history of cardiac dysrhythmias requiring anti-arrhythmia treatment(s) * history of abnormal laboratory results ≥2.5 × upper limit of normal (uln) * history of peripheral neuropathy * a known or clinically suspected infection with human immunodeficiency virus or hepatitis b or c viruses * prior medical history of bunionectomy or other foot surgery * intolerant of or unwilling to receive hydrocodone, acetaminophen, or ibuprofen * for female subjects: pregnant, nursing, or planning to become pregnant during the study or within 90 days after the last study drug dose * for male subjects: male subjects with a female partner who is pregnant, nursing, or planning to become pregnant during the study or within 90 days after the last study drug dose after surgery: * subject had a type 3 deformity requiring a base wedge osteotomy or concomitant surgery such as hammertoe repair; or experienced medical complications during the bunionectomy that, in the opinion of the investigator, should preclude randomization other protocol defined inclusion/exclusion criteria may apply.
randomized pilot trial of ayuda program for younger latinx adults with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the study will evaluate the feasibility, acceptability, and effectiveness of ayuda (assisting younger adults with diabetes), a 12-week culturally text message program for latinx adults newly diagnosed with type 2 diabetes who are caregivers to a child under 18 years old within kaiser permanente northern california.

after designing the ayuda program with input from the people it is meant to help, we are conducting a randomized pilot study. this study will test the program with younger latinx adults who have recently been diagnosed with type 2 diabetes and who are also caregivers for dependent children. ayuda is a health system specifically designed for this group, focusing on their life stage as young adults and their cultural background. the study will evaluate how well ayuda helps participants reach important early blood sugar control goals, which can lead to better health over time and reduce complications.

Eligibility criteria:
inclusion criteria: * kpnc member, age \>18 and age \<45 with * new clinical diagnosis of t2d within the prior 6 months * caregiver to at least one child \<18 years of age at time of diabetes diagnosis * identifies at latino/a/x * can receive text messages * proficient (written and spoken) in english or spanish exclusion criteria: * pregnant women * type 1 diabetes
botulinum toxin injection versus anal myectomy in management of idiopathic constipation

Conditions: Chronic Idiopathic Constipation; Functional Constipation

Summary: chronic idiopathic constipation is most common cause of constipation in childhood with numerous cases in egypt. numerous conservative measures were tried but many fail. surgical options include longitudinal myectomy of the muscle or injection of botulinum toxin. objectives: comparative study between botulinum toxin injection and myectomy in treatment of idiopathic constipation

functional constipation (chronic idiopathic constipation) is most common cause of constipation in pediatric age group. many cases try conservative treatment but fail to respond. these cases are treated by surgical longitudinal myectomy of the anal sphincter. now, there have been many trials of trying injection of botulinum toxin to relax the sphincter as a treatment of functional/idiopathic constipation. in this study, the investigators will compare the results of botulinum toxin injection versus surgical myectomy to treat functional/idiopathic constipation in children.

Eligibility criteria:
inclusion criteria: * children with idiopathic constipation exclusion criteria: * hirschsprung's disease or anorectal malformations
validity of the shd-less scale after acl reconstruction

Conditions: ACL Reconstruction; ACL Injury

Summary: after anterior cruciate ligament reconstruction (acl-r), single hop for distance (shd) performance aids in decision-making, particularly for return-to-sport assessments. however, asymmetrical landing kinematics are common after acl-r, even with symmetrical performances, and increase the risk of re-injury. to support clinical practice, several qualitative scales have been developed as valid and reliable tools for assessing landing quality. in 2022, measson et al. adapted the landing error scoring system for use during an shd task (shd-less scale) and demonstrated its reliability among healthy individuals. the aim of this study is to test the validity of this scale after acl-r by evaluating its ability to identify asymmetrical landing and characterize differences between the operated and uninjured limb. the second objective is to assess its association with knee muscle strength, functional status and psychological readiness.


Eligibility criteria:
inclusion criteria: * patients aged 18-40, who have undergone a first acl reconstruction more than 6 months ago and are being followed in a sports medicine care pathway * affiliated with a health insurance plan * information form: non-objection to the use of data for research purposes exclusion criteria: * previous ligament surgery of the lower limbs prior to acl reconstruction * complex ligament injury (lateral ligaments, posterior cruciate ligament) * recent muscle injuries * history of injury to the uninjured knee * pregnant woman * inability to perform a muscular assessment * postoperative complications (deep vein thrombosis, sepsis, stiffness/arthrofibrosis) * neurological history with residual effects or taking medication that affects balance/coordination
effects of tot on walking in children with cp

Conditions: Cerebral Palsy

Summary: the purpose of the study was to determine the effects of task oriented training (tot) on walking and balance in children with spastic cerebral palsy (cp).

the aim of study is to evaluate the effectiveness of task-oriented training on the walking in cerebral palsy children and compare its results with that of the conservative rehabilitation treatment. by training children to walk using task oriented training not only improves their walk and balance but also encourage them to actively participate in their own treatment process. task oriented training approach can prove to be an effective technique for those cp children who can perform ambulation and have defined targets for gross motor activities

Eligibility criteria:
inclusion criteria: * spastic cp children of age between 4 to 14 years * with spasticity 2 or less on modified ashworth scale * who can walk (gmfcs level 1-3) and can * can perform different activities on command exclusion criteria: * children with cognitive impairment * lower limb surgery in last 6 months * tetraplegic cp and who are unable to walk and follow command

Keywords: cerebral palsy walking task oriented training conventional therapy balance
growth hormone co-treatment within a gnrh antagonist protocol in patients with poor ovarian response

Conditions: Infertility, Female

Summary: in this study, the investigators will assess the efficacy of growth hormone co-stimulation to gnrh antagonist regimen in poor responders to coh for ivf.

to date, a limited number of studies have been performed in order to assess whether the addition of gh can improve the probability of pregnancy in poor responders undergoing ovarian stimulation for ivf. moreover, the existing studies are underpowered and, thus, inconclusive. in this study, the investigators will assess the efficacy of growth hormone co-stimulation to gnrh antagonist regimen in poor responders to coh for ivf.

Eligibility criteria:
inclusion criteria: * serum anti-müllerian hormone (amh) less than 1.2 ng/ml exclusion criteria: -

Keywords: ivf growth hormone poor responders
timing of mobilization on delirium in patients after cardiac surgery

Conditions: Patients After Cardiac Surgery

Summary: early mobilization is recommended because it is effective in improving symptoms for patients after cardiac surgery. however, the optimal timing of mobilization for postoperative patients is not unclear. how early is early? as early mobilization in the icu is safe and may reduce healthcare costs, the goal was to assess the effect of early mobilization in the icu on the incidence and duration of delirium.

the prevalence of cardiac diseases is high, as the standard treatment for many heart diseases, a bunch of strategies are performed to improve the outcome of cardiac surgery. early mobilization is recommended because it is effective in improving symptoms for patients after cardiac surgery. however, the optimal timing of mobilization for postoperative patients is not unclear. how early is early? as early mobilization in the icu is safe and may reduce healthcare costs, the goal was to assess the effect of early mobilization in the icu on the incidence and duration of delirium.

Eligibility criteria:
inclusion criteria: * 1. \> 18-year-old postoperative cardiac patient admitted to icu, the time \< 24h * 2. patients agree to participate in clinical research and sign informed consent before the start of the study exclusion criteria: patients who meet any of the following criteria are not eligible for inclusion in this study: * 1. pregnant and lactating women * 2. there are contraindications to getting out of bed： * 2.1 low cardiac output syndrome * (1) application of iabp or pcps (percutaneous cardiopulmonary support) * (2) high doses of vasoactive drugs (norepinephrine\> 0.5ug/kg.min) * (3) sbp\<=80mmhg * (4) acrocyanosis, wet and cold * (5) metabolic acidosis * (6) urine output less than 0.5ml/kg.h for more than 2 hours * 2.2 heart rate greater than or equal to 120 beats per minute at rest * 2.3 orthostatic hypotension (systolic blood pressure less than 80 mmhg after postural change) * 2.4 presence of arrhythmias leading to a drop in blood pressure (e.g., decreased blood pressure due to new-onset atrial fibrillation) * 2.5 difficulty breathing at rest or respiratory rate greater than 30 breaths per minute * 2.6 postoperative bleeding (200ml in 2-3 hours)
routine antenatal care versus screening and treatment of malaria in pregnancy in rwanda

Conditions: Malaria in Pregnancy

Summary: the main aim of this study is to test the primary hypothesis that the addition of intermittent screening and treatment of malaria in pregnant women (istp) who receive routine antenatal care (anc) in health facilities in high malaria transmission areas in rwanda will reduce malaria prevalence among pregnant women when compared to routine antenatal cares services alone.

more specifically, the primary objective is to understand the effect of istp in a context where routine antenatal care does not include malaria chemoprohylaxis and whether this intervention is protective against malaria during pregnancy. the secondary objective is to determine whether this intervention results in an improvement in other key maternal and newborn health outcomes including maternal anemia, low birth weight and prematurity. the third objective is to determine the feasibility, effectiveness and acceptability of istp among women who receive istp and among health workers who deliver this intervention. this study will establish if testing and treating pregnant women is effective, feasible and whether it adds an additional burden to the work already being undertaken by facility-based health workers who provide antenatal care services. it is expected that the study will result in information to develop appropriate approaches that can be implemented in rwanda in the prevention of malaria in pregnancy in addition to the use of preventive measures such as insecticide treated mosquito nets (itns) and case management. this information may potentially also be used by other countries with similar patterns of malaria transmission.

Eligibility criteria:
inclusion criteria: * pregnant women age 18 or older who have their first anc visit during the study recruitment period * willing to participate exclusion criteria: * • pregnant women below the age of 18 * not willing to participate
utilization of very low calorie diet in obese general surgery patients

Conditions: Morbid Obesity

Summary: the investigators are studying the use of a two-week very low calorie diet (vlcd) in obese general surgery patients in a randomized single-blinded trial. the investigators hypothesize that the vlcd will positively impact the perceived surgical difficulty, operative time, hospital length of stay and 30-day complications. additionally, the investigators anticipate reduced perioperative blood glucose levels and a reduced need for perioperative insulin administration.

the investigators' objective for this project is to determine the impact of a preoperative vlcd on outcomes for patients undergoing elective general surgery. included are patients who are obese, bmi \>30, and scheduled by a christiana care-employed general surgeon for elective general surgery. eligible patients are those scheduled for elective cholecystectomy, ventral or incisional hernia, umbilical hernia, and inguinal hernia surgery. the investigators will also be determining the feasibility of introducing a preoperative vlcd for patients undergoing elective general surgery in a community hospital setting.

Eligibility criteria:
inclusion criteria: * patients who are obese, bmi \>30, and scheduled by a christiana care-employed general surgeon for elective general surgery. * patients between the ages of 18 and 65. * patients scheduled for elective cholecystectomy, ventral or incisional hernia, umbilical hernia, and inguinal hernia surgery. exclusion criteria: * patients will be excluded from the study if they have any of the following: 1. recent myocardial infarction (3-6 months). 2. history of cerebral vascular accident (stroke). 3. diabetes mellitus with a history of severe ketoacidosis. 4. patients on sglt2 inhibitors (glifozins) without insulin 5. chronic use of steroids, greater than 20mg daily. 6. bleeding peptic ulcer (unless there is radiological evidence of healing 6 months prior to entry). 7. a psychiatric history that includes suicide attempts and anyone taking psychotropic drugs, including lithium carbonate. 8. active thrombophlebitis (or any other condition where decreased blood volume would put the patient at risk). * in addition, patients who are pregnant are excluded. if status is unknown, a pregnancy test will be required prior to the start of the vlcd.

Keywords: very low calorie diet general surgery
erector spinae versus paravertebral in pediatric pcnl

Conditions: Renal Stone; Percutaneous; Nephrolithotomy

Summary: to compare the efficacy of ultrasound-guided erector spinae plane block versus ultrasound-guided paravertebral block in pediatric patients undergoing percutaneous nephrolithotomy

percutaneous nephrolithotomy (pcnl) is a commonly performed surgical procedure for complex upper renal tract calculi. although the skin incision for pcnl appears small, the intensity of intraoperative and postoperative pain is significant owing to soft tissue injury. erector spinae plane (esp) block is an interfascial block that was first described by forero et al. in 2016. it can be performed by injecting the local anesthetic in the deep interfascial plane of the erector spinae muscle to provide both visceral and somatic analgesia with a sensory level from t2-4 to l1-2. . paravertebral block is the technique of injecting local anesthetics in a space immediately lateral to where the spinal nerves emerge from the intervertebral foramina. this technique is used increasingly for intra-operative and post-operative.

Eligibility criteria:
inclusion criteria: * patients undergoing percutaneous nephrolithotomy exclusion criteria: * coagulation disorders * infection at the site of injection * allergy to the local anesthetics used * spinal cord abnormalities or neurological deficits

Keywords: paravertebral block erector spinae plane block percutaneous nephrolithotomy pediatric
alternative surveillance program for patients with high risk group of hcc

Conditions: Hepatocellular Carcinoma

Summary: in a high-risk group, ultrasonography at 6-month intervals and short-protocol magnetic resonance imaging at 1-year intervals were performed. sensitivity, specificity, positive and negative predictive values for very early stage hcc are compared between conventional (biannual us) and alternative surveillance test are compared


Eligibility criteria:
inclusion criteria: * chronic hepatitis b or c * child-pugh classification a * hcc risk score \>= -2.04 * have not diagnosed with hcc * on surveillance program using us and negative on previous us within 6-8 months of enrollment * sign informed consent exclusion criteria: * younger than 40 years or older than 70 years old * history of hcc * severe gfr or on hd/pd due to renal failure * contra-indication of mri * congestive hepatopathy * iron deposition * pregnancy or nursing mother * non-viral hepatitis or liver cirrhosis

Keywords: us mri hcc surveillance risk estimation
new era of diep with minimally invasive mastectomy

Conditions: Breast Reconstruction; Mastectomy; Lymphedema

Summary: the free deep inferior epigastric artery perforator (diep) flap is the gold standard in autologous breast reconstruction. asian patients often present with a smaller body mass index with relatively insufficient tissue. to restore appropriate symmetry, a larger flap inset ratio must be transferred. supercharging of the second vein or inclusion of bilateral pedicle is commonly required. current paradigm shifts in mastectomy has also resulted in more minimally invasive surgeries (mis) espousing smaller lateral incisions, leading to a significant change in available recipient vessels. this study aimed to demonstrate our experience in changing strategies of diep flaps following the evolution of mastectomy techniques. between october 2008 and march 2022, retrospective data was gathered for 278 patients who underwent breast reconstruction surgery utilizing diep flaps by a single plastic surgeon. these patients were divided into two distinct groups based on their operation dates, with november 2018 marking a pivotal moment when the first mis was introduced.


Eligibility criteria:
inclusion criteria: * all patients who underwent breast reconstruction procedures with diep flaps from october 2008 to march 2022. * patients who have a minimum follow-up duration of six months post-reconstruction. exclusion criteria: * patients who did not meet the six-month follow-up duration was excluded from the study.
developing an ecological and tailored nutritional intervention to improve quality of life in esophageal cancer survivors

Conditions: Esophageal Cancer

Summary: this study aims to apply and assess the clinical feasibility of a health behavior theory-based ecological nutrition intervention program, providing nutrition care tailored to the unmet needs of esophageal cancer survivors after surgery. esophageal cancer survivors will receive a 4-week nutrition intervention program tailored to their individual nutritional needs. the program includes providing nutritional guidelines, customized care food, encouraging walking through a wearable device, and weekly telephone counseling. the evaluation of the program will assess food intake, adherence to dietary guidelines, activity level, nutritional indicators (such as pni and nri), weight change, fatigue, symptoms, quality of life, and satisfaction with meals and services. additionally, interviews will be conducted after the intervention to evaluate the patient's experience.


Eligibility criteria:
inclusion criteria: * patients with clinical stage 1-3 primary esophageal cancer at diagnosis who have planned or received treatment, including esophageal resection and reconstruction, with curative intent, and their families\*. * you are at least 18 years of age * have a native-level understanding of korean * who consented to this study exclusion criteria: * concurrent multiple cancers at the time of diagnosis or a history of diagnosed and treated other organ cancers within the past year at the time of diagnosis * have had esophageal resection and reconstruction surgery for other reasons before being diagnosed with esophageal cancer * persons with limited cognitive and communication abilities * the patient has had problems progressing to oral feeding after surgery, requiring a concurrent ileostomy, or the investigator determines that an interventional study is not appropriate. * individuals with reduced renal function for whom protein intake is not recommended (estimated gfr \<60 ml/min/1.73 m2) * people who are unable to walk due to joint problems, paralysis, etc. * those who do not use smartphones

Keywords: nutritional intervention nutrition survivors esophageal cancer care foods health behavior ecological intervention