Kornimate/medical-research-clean huggingface dataset:
polyphenols, prebiotics, the gut microbiome and stress

Conditions: Stress, Psychological; Gut Bacteria

Summary: the aim of this study is to evaluate how different combinations of prebiotics and polyphenols affect the gut microbiota and perceived cognitive state. 40 volunteers will take part in this study who will be randomised into 4 different groups. one group will consume a placebo, whereas the other groups will consume prebiotics, polyphenols, or a combination of the two.

* all participants will be asked to fill out a health screening questionnaire and inclusion/exclusion criteria will be reviewed for volunteer eligibility * valid informed consent will be obtained from the volunteer. * once the study begins, participants will be randomly allocated into 1 of 4 groups each assigned a different polyphenol or prebiotic product. the prebiotic content is dosed as follows: inulin at 5g/d, gos at 5g/d and resistant starch at 20g/d. * participants will be asked to consume their assigned product once per day. the length of the intervention is 14 days * participants will provide two stool samples: one on day 0 and one on day 14 of the study to identify changes in gut microbiota composition * urine samples will also be provided at day 0 and at day 14 looking for changes in urinary metabolites * participants will also be asked to fill out various mood related questionnaires on days 0 and 14 of the study. * you will take your own blood pressure and heart rate on day 0 and day 14 and at least 3 times per week to try and link changes in gut microbiota composition with vascular health. * volunteers will be given containers and specimen pots to take home for initial and final faecal and urine collections. no treatment will be issued until initial stool and urine sample has been provided * maintenance of normal dietary patterns throughout the study is essential and participants will be required to complete food and drink logs throughout the study via a web-based app - on three consecutive days with one of the days being a weekend

Eligibility criteria:
inclusion criteria: * volunteer is healthy at the time of pre-examination * volunteer has high perceived stress levels (own self-assessment) * volunteer is aged ≥ 18 to ≤ 65 years at the time of pre-examination * volunteer is able and willing to comply with the study instructions * volunteer is suitable for participation in the study according to the investigator/study personnel * written informed consent is given by volunteer exclusion criteria: * no command of any local language * gastrointestinal disorders including ibs, ibd or other conditions that might affect the gut environment * food allergies or intolerances * using drugs (e.g. antibiotics) influencing gastrointestinal function (8 weeks before intervention) * use of laxatives * participants with any form of diagnosed diabetes (types i and ii) * volunteers currently involved or will be involved in another clinical or food study * history of drug (pharmaceutical or recreational) or alcohol abuse. * participants are pregnant or are lactating * regular intake of probiotic or prebiotic supplements * smoking
language proficiency and quality of life after receiving cochlear implantation as a child

Conditions: Hearing Loss

Summary: treatment with cochlear implantation is now offered to proximately 95 % of children with deafness in norway. more than 500 children have been operated at oslo university hospital. the study is a cross-sectional study aimed to investigate speech perception, language skills, quality of life in all childhood cochlear implant (ci) recipients in norway from 1988-2012. factors such as child characteristics, characteristics with the family, the cochlear implant, the rehabilitation situation, choice of communication mode, school and work situation are surveyed to see if these factors can be associated with variations in outcome. the study will include pre and post lingual deaf children and children with multiple disabilities. participants are recruited and examined in conjunction with their annual ci control at the hospital. it will be conducted a series of tests determining listening, speech and language development, non-verbal intelligence. questionnaires are used to collect background information and quality of life experience. the questionnaires include self-report forms for different age groups, and a parent report form. the patient will be tested for the most common genetic causes of deafness. additional data will be collected from patient records and from local health register at oslo university hospital.

test protocol includes: hearing and language assessment: single syllable word perception, hearing in noise test (hint), mullen scale of early learning, british picture vocabulary scale, peabody picture vocabulary test - fourth edition, clinical evaluation of language fundamentals (celf) - fourth edition 4 , raven progressive matrices, motor coordination + visual perception (vmi), wechsler preschool and primary scale of intelligence (wppsi), wechsler intelligence scale for children (wisc) and wechsler adult intelligence scale (wais). quality of life assessment: satisfaction of life scale for children pediatric quality of life inventory tm (pedsql tm) questionnaire for quality of life assessments (kindl)

Eligibility criteria:
inclusion criteria: * all people in norway that have received cochlear implants as a child and that have one or more than one year with ci experience. exclusion criteria: * cochlear implant users with less than one year with ci experience and people implanted after 18 years of age.

Keywords: cochlear implant hearing loss language development quality of life
effects of prebiotic oral healthcare products as an adjunct to non-surgical periodontal therapy

Conditions: Periodontitis

Summary: the aim of this study is to determine the impact of a prebiotic toothpaste and mouthrinse in periodontitis patients as an adjunct to scaling and rootplaning.

the aim of this study is to determine the impact of a prebiotic toothpaste and mouthrinse in periodontitis patients as an adjunct to scaling and rootplaning. study design: this study will be a single centre (department of oral health sciences, university hospitals leuven), double blind, randomized, placebo controlled clinical trial. the randomization (by means of a computer program) and double blind design are thought to minimize the bias of the investigator and patients. study population: adults, who consult at the department of periodontology at the university hospital leuven and who fit the inclusion criteria will be asked to participate in this study.

Eligibility criteria:
inclusion criteria: * 40 patients * ≥ 36 years of age - page 4 of 4 \[draft\] - * no previous scaling and rootplaning * clinical diagnosis: severe generalized periodontitis characterized by the presence of \> 14 affected teeth when \> 14 teeth are present (if number of teeth present is \ 6mm prior to initial non-surgical periodontal therapy. * a minimum of 3 natural teeth in every quadrant * willing and able to give written informed consent exclusion criteria: * patients with aggressive periodontitis or necrotizing periodontitis * patients who smoke * pregnant or lactating woman * a history of diabetes, rheumatic fever, liver or kidney disease, neurological deficiencies, or use of medication which may affect periodontal tissue, (phenytoin, cyclosporin, nifedipine, chronic use of non-steroidal antiinflammatory drugs) * patients with poorly controlled diabetes * patients taking bisphosphonate mediation * patient who have taken systemic antibiotics 3 months prior to treatment
amg 714 expanded access program

Conditions: Celiac Disease

Summary: expanded access requests for amg 714 may be considered for adult patients with biopsy proven refractory celiac disease type ii who have failed all available treatment options and do not have eatl. to request access, use responsible party contact information provided in this record.


Eligibility criteria:
inclusion criteria: - exclusion criteria: -

Keywords: refractory celiac disease type ii
boxx-noaf clinical trial

Conditions: Post Operative Atrial Fibrillation; Atrial Fibrillation, Postoperative

Summary: post operative atrial fibrillation (poaf) is the most common complication of cardiac surgery. poaf incidence can exceed 50% depending on the patient baseline characteristics and surgery type. patients with poaf tend to have worse acute and long-term clinical outcomes. boxx-noaf is a randomized trial to evaluate if prophylactic ablation and exclusion of the left atrial appendage at the time of other routine cardiac surgery can reduce the incidence of post operative af and clinical af during long term follow up in patients who have not yet developed af but are at risk.


Eligibility criteria:
inclusion criteria: * planned and clinically indicated for cardiac surgical procedure requiring cardiac bypass and opening of the pericardium * age ≥ 65 years and cha2ds2-vasc ≥ 3 exclusion criteria: * documented history of atrial fibrillation or atrial flutter anytime prior to the cardiac surgery * prior procedure involving opening the pericardium or entering the pericardial space * patients undergoing off-pump surgery * prior laa occlusion, exclusion, or removal (surgical or percutaneous) * presence of a permanent pacemaker * infiltrative cardiomyopathies (i.e. amyloidosis) * planned cardiac surgical procedure using non-sternotomy approaches * patients whose planned procedure is a heart transplant or implantation of any long-term ventricular assist devices * presence of ventricular arrhythmia * active endocarditis * nyha class iv heart failure symptoms * preoperative need for an intra-aortic ballon pump or intravenous inotropes * active systemic infection at the time of cardiac surgery requiring antibiotics * known allergy to nitinol or nickel sensitivity * known medical condition with expected survival of less than 1 year * other comorbidities that in the investigator's opinion make the subject unsuitable candidate to complete the protocol required intervention or visits * current enrollment in an investigation or trial or an investigational devices or investigational drug that would interfere with this trial * mental impairment or other psychiatric conditions which may not allow the patient to understand the nature, significance, and scope of the trial. * pregnancy * known severe symptomatic carotid disease

Keywords: post operative af clinical af
self-administered program in chronic neck pain

Conditions: Chronic Neck Pain

Summary: neck pain is a complex biopsychosocial disorder often precipitated or aggravated by neck movements or sustained neck postures. the onset and course of this pain are influenced by environmental and personal factors. many studies report that participants preferred self-care measures for the management of neck pain and they sought professional help only when those measures fail.

neck pain is the fourth leading cause of disability worldwide causing an enormous impact on individuals and their families, communities and healthcare systems.while neck pain can be severely disabling and costly, treatment options have shown moderate evidence of effectiveness. no previous study has used foam roller in patients with neck pain. in addition, it has been suggested that neurodynamic interventions provide a peripheral stimulus, reducing the pressure existing within the nerve, improving blood flow, axonal transport and nerve conduction. it was hypothesized that a self-administered intervention focused on myofascial release of main muscles related to neck pain and upper-limb active neurodynamics could reduce the presence of active trigger points and pain, improving functionality and active mobility.

Eligibility criteria:
inclusion criteria: * chronic neck pain (at least 3 months' duration) not related to trauma of at least 3 on a visual analogue scale * participants' symptoms had to be reproduced by median nerve upper-limb neurodynamic test. exclusion criteria: * exclusion criteria: * whiplash related neck pain * previous cervical surgical intervention * cognitive impairments which prevent them to follow instructions * visual or acoustic limitations * physical therapy in the previous six months

Keywords: chronic neck pain
study on screening strategies for interstitial lung abnormalities and airway lesions

Conditions: Interstitial Lung Abnormalities

Summary: the goal of this observational study is to learn about the comorbidity patterns of interstitial and airway abnormalities in adults undergoing health examinations in china. the main questions it aims to answer are: how do early interstitial lung abnormalities progress to comorbid interstitial and airway diseases? what are the key factors associated with this progression? participants undergoing routine health examinations will be assessed for interstitial and airway abnormalities based on imaging and clinical data. longitudinal follow-up will be used to evaluate disease progression and identify associated risk factors.


Eligibility criteria:
inclusion criteria: * underwent chest ct examination between january 1, 2017 and december 31, 2024 * age 18 years or older at the time of examination exclusion criteria: - missing or incomplete key demographic or imaging information (e.g., missing date of examination, sex, age, or ct report)

Keywords: interstitial lung abnormalities
qol outcomes in crs with polyps

Conditions: Chronic Rhinosinusitis, Polyps

Summary: chronic rhinosinusits (crs) is common disease with reports of prevalence ranging from 4-16% in the western population. the main outcome measure for chronic disease treatment, such as crs, is quality of life. several large multi-institutional studies have shown that improvement in disease specific quality of life was greater in patients who had surgery for their crs with polyps. the timing of surgery in these patients has not been well studied but it is generally agreed upon that surgical candidates much had failed medical management. the definition of medical management varies greatly but usually includes some form of nasal or oral steroids and a prolonged ( \>10 days) course of antibiotics. another known way to improve qol is through education and individualized optimization. this has been utilized successfully in other fields with good success and improved qol. similar studies looking at combining non-surgical optimization and education have not been performed in crs. this study aims to address this potential area for improvement in patient quality of life outcomes. investigators plan to assess the potential role for pre-operative non-surgical medical and educational optimization in crs standard of care treatment.


Eligibility criteria:
inclusion criteria: * adults with rhinosinusitis with polyps who have had appropriate treatment qualifying them for surgery and are good surgical candidates exclusion criteria: * cystic fibrosis, cilia disorders, other specialized forms of sinus disease
study of inbrx-109 in conventional chondrosarcoma

Conditions: Conventional Chondrosarcoma

Summary: randomized, blinded, placebo-controlled, phase 2 study of inbrx-109 in unresectable or metastatic conventional chondrosarcoma patients.

this is a randomized, blinded, placebo-controlled, phase 2 study of inbrx-109 in unresectable or metastatic conventional chondrosarcoma patients. inbrx-109 is a recombinant humanized tetravalent antibody targeting the human death receptor 5 (dr5).

Eligibility criteria:
inclusion criteria: 1. conventional chondrosarcoma, unresectable (=inoperable) or metastatic. 2. measurable disease by recistv1.1. note: tumor lesions located in a previously irradiated (or other locally treated) area will be considered measurable, provided there has been clear imaging-based progression of the lesions since the time of treatment. 3. radiologic progression of disease per recistv1.1 criteria within 6 months prior to screening for this study. 4. adequate hematologic, coagulation, hepatic and renal function as defined per protocol. 5. eastern cooperative oncology group performance status (ecog ps) of 0 or 1. 6. estimated life expectancy of at least 12 weeks. 7. availability of archival tissue or fresh cancer biopsy are mandatory. exclusion criteria: 1. any prior exposure to dr5 agonists. 2. allergy or sensitivity to inbrx-109 or known allergies to cho-produced antibodies. 3. non-conventional chondrosarcoma, e.g., clear-cell, mesenchymal, extraskeletal myxoid, myxoid, and dedifferentiated chondrosarcoma. 4. prior or concurrent malignancies. exception: patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessments. 5. chronic liver diseases. exception: patients with fatty liver disease are acceptable as long as adequate hepatic function as defined in the inclusion/exclusion criteria is confirmed. 6. evidence or history of multiple sclerosis (ms) or other demyelinating disorders. 7. other exclusion criteria per protocol.

Keywords: dr5 inbrx-109 apoptosis programmed cell death
in vitro fertilization outcomes of two treatment protocols in women with polycystic ovary syndrome

Conditions: PCOS GnRH Antagonist and GnRH Agonist IVF/ICSI Cycles

Summary: outcomes of ivf/icsi cycles of women with pcos undergoing gonadotropin releasing hormone (gnrh) agonist and gnrh antagonist fixed protocol.

women with pcos undergoing ivf/icsi cycles will be evaluated by two different protocols. one arm of the study includes oral contraceptive plus gnrh agonist protocol with 150 iu fsh (standard dose) and second arm includes oral contraceptive plus gnrh antagonist with 150 iu fsh dose and fixed 6th day starting of gnrh antagonist.

Eligibility criteria:
inclusion criteria: * pcos women undergoing icsi cycles * all women will be administered 150 iu rec fsh exclusion criteria: * women having other endocrinopathies * women older than 35 * third ivf/icsi cycles * previous and current use of metformin

Keywords: pcos ivf/icsi clinical pregnancy rates gnrh antagonist gnrh agonist
effects of acupuncture in spontaneous rapture of membranes: applicability and effectiveness

Conditions: PROM (Pregnancy); Induced; Birth; Acupuncture; Labour; Cervical Ripening

Summary: the aim of the study is to investigate the effects of acupuncture in women presenting with spontaneous rapture of membranes (prom) at term and negative swab for streptococcus agalactie to promote a spontaneous onset of labour and avoid labour induction after 24 hours, accordingly to our policy. secondary outcomes were considered the duration of first and second stage of labour, the time elapsed between prom and delivery.


Eligibility criteria:
inclusion criteria: * prom after 37 weeks of gestation * absence of maternal and fetal complications * negative swab of streptococcus agalactiae * limpid amniotic fluid * absence of uterine contractions after 6 hours of observation * single pregnancy exclusion criteria: * prom before 37 weeks of gestation * presence of maternal and fetal complications * positive swab of gbs * m1 - m3 amniotic fluid * regular uterine contractions during the first 6 hours of observation * twin pregnancy
a prospective study of a new immunochemical fecal occult blood test in u.s. veteran patients undergoing colonoscopy

Conditions: Colon Cancer

Summary: the purpose of our study is to evaluate the diagnostic validity of a new immunofecal occult blood test (ifobt) (teco diagnostics) in u.s. veterans and to compare it with the guaiac based fobt.

colorectal cancer (crc) is the third most common cancer in men and women in the united states with an estimated 147,000 new cases and more than 56,000 deaths each year. early detection of colon cancer and removal of precancerous adenomatous polyps have been shown to reduce its morbidity, mortality and incidence. there are several recommended crc screening tests, including fecal occult blood test (fobt), flexible sigmoidoscopy, air-contrast barium enema, and colonoscopy. in the va, fobt is the predominant screening test for crc. numerous randomized controlled trials have established the efficacy of fobt in crc screening. its advantages include privacy, noninvasiveness, and cost-effectiveness. use of guaiac-based testing, however, is hampered by low patient compliance, sensitivity, specificity, and positive predictive value. the poor patient compliance, and low specificity and positive predictive value, may be related to the testing procedure. for example, dietary and medication restrictions are recommended to decrease false-negative and false-positive tests. such restrictions may impede patient compliance. recently, several studies have evaluated the effectiveness immunochemical-based testing as a potential alternative, with reportedly better compliance, sensitivity, and specificity than guaiac-based tests. the purpose of our study is to evaluate the diagnostic validity of a new ifobt (teco diagnostics) in u.s. veterans and to compare it with the guaiac based fobt.

Eligibility criteria:
inclusion criteria: * patients (men or women) that are \>18 years of age undergoing colonoscopy for a variety of indications (bleeding, diarrhea, weight loss, anemia, abdominal pain, etc) exclusion criteria: * concurrent hospitalization * visible rectal bleeding * known diagnosis of inflammatory bowel disease * hematuria * menstruation at the time of obtaining a stool specimen and performing the tests * inability to prepare the 3 different ifobt or 3 different fobt kits

Keywords: colon cancer screening immunofecal occult blood test colonoscopy diagnostic validity