Kornimate/medical-research-clean huggingface dataset:
quick returns - sleep, cognitive functions and individual differences

Conditions: Shift Work Schedule; Sleep Deprivation

Summary: the project will contribute with new knowledge concerning how short rest periods between two consecutive shifts (\<11h, often defined as a quick return (qr)) affects sleep and cognitive performance. the study will further examine whether individual differences in personality traits and genotypes may explain individual differences in performance and sleep. data will be collected with a randomized cross-over design, in an experimental laboratory setting.

rotating shift workers may have a narrow time window to rest after an evening shift, before returning early to work for a day shift. in the literature, a rest opportunity of less than 11 hours between two consecutive shifts, is defined as a quick return (qr). most often, this is occurs when working an evening shift followed by a day shift. survey- and longitudinal studies have found associations between qrs and an increased risk of being involved in occupational accidents. however, no studies have experimentally investigated how a qr scenario may affect performance at work and sleep between the two shifts. thus, the project will experimentally simulate qrs, where a battery of cognitive tests will be administered in a laboratory to indicate performance. objective and subjective sleep will be measured/reported at home where participants normally sleep. additionally, genotype- and personality trait data will be collected and used as moderators in the analyses. a randomized cross-over design with two groups will be applied. in one condition, participants will work an evening shift (03:00pm-11:00pm) followed by a day shift (07:00am-03:00pm, qr). in the other condition, participants work a day shift (07:00am-03:00pm) followed by another day shift. four weeks later after being in one of the conditions, the participants will return to the laboratory and work in the opposite condition. sleep will be subjectively reported with a sleep diary and objectively measured using a low-powered ultra-wideband radar, two days before and between the two simulated shifts in each of the two conditions.

Eligibility criteria:
inclusion criteria: * participants are physically and mentally healthy (assessed with bmi and 'general health questionnaire-12)'. * participants accept to comply to the protocol (retain regular bed- and wake times before the simulated shifts). * refrain from alcohol and maintain regular nicotine and caffeine usage during participation. * norwegian as primary language/proficiency in norwegian language. exclusion criteria: * neurological, psychiatric or sleep related disorders ('bergen insomnia scale, 'global sleep assessment questionnaire'). * extreme 'morning-eveningness' type ('horne-östberg). * use of medication that affect sleep or cognitive performance. * pregnancy.

Keywords: shift work quick return sleep cognitive performance circadian rhythm genotype shift work tolerance
topical tacrolimus 0.03% ointment for intractable allergic conjunctivitis: an open label pilot study

Conditions: Allergic Conjunctivitis

Summary: the purpose of this study is to determine the efficacy, tolerance and safety of tacrolimus 0.03% ointment in the treatment of intractable allergic conjunctivitis.


Eligibility criteria:
inclusion criteria: * subjects included if they were \> 5 years old and suffered from intractable allergic conjunctivitis exclusion criteria: * pregnancy or breastfeeding,history of herpetic eye disease,transplant patients concomitant administration of drugs inhibiting cytochrome cyp3a4, hypersensitivity to macrolides
protect yourself: abuse prevention for people with intellectual disabilities

Conditions: Abuse Prevention

Summary: the purpose of this study is to help individuals and their caregivers develop a plan on how to recognize, deal with and respond to abusive situations.

the goal of this project is to address the current deficiencies by creating a program that will guide individuals who have intellectual disabilities and a learning partner (lp - care provider, relative, group home staff) in developing a comprehensive individual response plan (irp) that can be used before, during, and after an abusive event. behavioral skills training and behavioral relaxation training -- two instructional approaches with evidence for effectiveness in this population -- will be included to address the unique learning needs of people who have intellectual disabilities and to maximize opportunities for skill-based learning. video and workbook activities will train the lp to effectively implement the abuse prevention and response strategies, thus increasing the potential for generalization in the natural environment and long-term maintenance of skills.

Eligibility criteria:
inclusion criteria: * has moderate to mild mental retardation based on iq scores ranging from 40-70 * is over 18 years old. --the participant must be able to do three of the following four skills (1) complete a simple worksheet with assistance, (2) go on simple errands alone, (3) recognize 10 or more words by site, (4) read a digital clock. exclusion criteria: * individuals who have experienced traumatic abuse and experiences symptoms suggestive of trauma, such as flashbacks, nightmares, and chronic anxiety and/or depression that is resistant to standard pharmacological and psychotherapy/behavior interventions.

Keywords: intellectual disabilities abuse abuse prevention
treatment for anemic subjects with non-myeloid malignancies receiving chemotherapy

Conditions: Neoplasms; Anemia

Summary: the purpose of this study is to assess the ability of darbepoetin alfa to maintain hemoglobin concentrations greater than or equal to 10 g/dl when administered every 3 weeks (q3w).


Eligibility criteria:
inclusion criteria: - subjects with non-myeloid malignancies - anemia (screening hemoglobin concentration greater than or equal to 10.5 g/dl but less than or equal to 12.0 g/dl) related to cancer and chemotherapy - at least 8 additional weeks of cyclic chemotherapy planned regardless of schedule - karnofsky performance status of greater than or equal to 50% - serum creatinine concentration less than or equal to 2.0 mg/dl exclusion criteria: - iron deficiency - red blood cell (rbc) transfusion within 4 weeks of screening - unstable cardiac disease

Keywords: anemia darbepoetin alfa amgen non-myeloid malignancies
psychiatric disorder and postoperative morbidity in hip and knee artroplasty

Conditions: Focus is on Preoperative Psychiatric Charactarization of Elective Fast-track Hip and Knee Arthroplasty Patients

Summary: it has been established that patients with psychiatric disorders tend to do worse in a surgical setting. some types of surgery with greater impact than others, including orthopedic surgery. in our research group the investigators have shown this to be the case for hip and knee replacements within the mentioned patient category. however, the role of psychiatric disorder and use of different psychopharmacological drugs in relation to perioperative morbidity and mortality have not been thoroughly examined. the objective of this study is to shed light on the issue. recent studies have shown that different types of psychiatric disorder influence surgical outcome differently. this emphasizes the need for specific knowledge regarding psychiatric diagnoses preoperatively. in this study around 2000 patients with or without psychiatric disorder of any kind will be studied preoperatively, which according to our previous study will include more than 200 patients receiving psychopharmacological treatment. the specifics that characterize every patient's psychiatric trades will be included in a validated questionnaire constructed for that purpose. the questionnaire is called scl-92 and has been chosen in collaboration with professor in psychiatry, rigshospitalet anders fink-jensen. preoperative information regarding their mental condition and medicine will be linked to surgical outcome in order to identify potential hazards in the perioperative period.


Eligibility criteria:
inclusion criteria: * all patients planned for elective unilateral fast-track hip or knee arthroplasty. * age \> 18. * can understand and read danish. exclusion criteria: -
cross sectional survey on the burden, impacts and causes of hepatitis c virus (hcv) outbreak in south west region in burkina faso

Conditions: Hepatitis C Virus Infection, Past or Present; Chronic Hepatitis c

Summary: this study investigates hepatitis c virus (hcv) outbreak in south west general population in burkina faso with three specific objectives: estimate hcv prevalence in south west region general population in 2019; identify factors associated with recent hcv infection (in subjects younger than 20 years); and evaluate the pilot treatment strategy implemented by the national program for diagnosed cases during investigation.

a previous anrs (french national agency for research on aids and viral hepatitis)12270 study supported by burkina faso's minister of health, used blood samples from the 2010 demographic and health survey (dhs) to document the country's national and regional prevalences and highlighted a localized hcv epidemic in the southwest region with a prevalence of 13.2% which was 4 times higher than the national prevalence. this high prevalence of hcv was found in both adults and youth. given the particular epidemiological situation of the south-west region and the limits of the 2010 dhs, we aimed to carry out a thorough investigation of this hcv epidemic in the south-west region of burkina faso in order to control it. a mixed methodology (quantitative and qualitative) will be used including: (i) a cross-sectional survey to estimate the prevalence of hcv infection in the south-west population in burkina faso; (ii) a case-control study among individuals less than 20 years of age to identify factors associated with current hcv transmission; (iii) a qualitative survey to provide additional information explaining the high prevalence of hcv infection (historical events, for example); (iv) a cohort study to evaluate a pilot treatment management strategy to be implemented by the national program in the south west region

Eligibility criteria:
inclusion criteria: * to be a usual resident of the burkina faso south west region * express informed consent
evaluating the dose timing (morning vs evening) of endocrine therapy and its effects on tolerability and compliance

Conditions: Breast Cancer

Summary: endocrine therapy is an established treatment for hormone receptor-positive breast cancer, but can cause significant side effects with deterioration in quality of life. the side effects of all forms of endocrine therapy are well recognized and can lead to treatment non-persistence or non-compliance. chronotherapy, also called chronotherapeutics, is defined as the administration of a medication in coordination with circadian rhythm in order to minimize side effects and yield a greater efficacy. the investigators propose to perform a pragmatic, multi-centre, open-label, randomized clinical trial to establish the optimal timing (morning vs. evening) of administering endocrine therapy based on side effects and benefits in early stage breast cancer patients.

endocrine therapy is an established treatment for hormone receptor-positive breast cancer, but can cause significant side effects with deterioration in quality of life. the side effects of all forms of endocrine therapy are well recognized and can lead to treatment non-persistence or non-compliance. compliance is defined as the degree or extent of conformity to the recommended administration by the provider, whereas persistence refers to the act of continuing treatment for a certain prescribed duration. treatment adherence is especially important in breast cancer, as early cessation or reduced compliance to hormonal therapy are associated with reduced disease-free survival and increased mortality. chronotherapy, also called chronotherapeutics, is defined as the administration of a medication in coordination with circadian rhythm in order to minimize side effects and yield a greater efficacy. the investigators propose to perform a pragmatic, multi-centre, open-label, randomized clinical trial to establish the optimal timing (morning vs. evening) of administering endocrine therapy based on side effects and benefits in early stage breast cancer patients.

Eligibility criteria:
inclusion criteria: * patients with an early stage or locally advanced hormonal receptor positive breast cancer * plan to receive endocrine therapy * 18 years of age or older * able to provide oral consent * willing and able to complete questionnaires as per study protocol exclusion criteria: * metastatic cancer * previous endocrine therapy for breast cancer

Keywords: breast cancer endocrine therapy chronotherapy chronotherapeutics
caldolor versus caldolor plus ofirmev in total knee or hip arthroplasty surgeries

Conditions: Pain

Summary: the objective of this study is to compare the effectiveness and of perioperative use of caldolor alone and in combination with ofirmev in total knee or hip arthroplasty procedures.

patients undergoing total knee or hip arthroplasty procedures at university pain institute at hahnemann will be included in this study. following institutional review board's approval, eligible patients will be selected from the pre admission testing for total knee or hip arthroplasty surgeries planned at hahnemann university hospital. the cases will be randomized in a 1:1 ratio into either group 1 or group 2. group 1 will receive 800 mg caldolor at the induction of anesthesia, followed by 800 mg caldolor every 6 hours until discharge or for a total up to 120 hours (5 days) group 2 will receive 800 mg caldolor at the induction of anesthesia and 1000 mg ofirmev at the time of surgical wound closure, followed by 800 mg caldolor plus 1000 mg ofirmev every 6 hours until discharge or for a total up to 120 hours (5 days) after the surgery, at the request of the patient they could receive morphine administered by patient-controlled analgesia pump, or by hospital staff. the analgesics and procedures involved in this study are all standard of care drugs prescribed and administered by the attending anesthesiologist for control of total knee or hip arthroplasty surgery related pain. data collected for every patient will exist in the patient's medical chart as part of their standard medical care. no additional patient procedures or activities are mandated by this study. the data collection and analysis will be completed in duration of 1 year

Eligibility criteria:
inclusion criteria: * adult patients age 18-70 scheduled for total knee or hip arthroplasty surgery * american society of anesthesiology physical status i, ii, iii exclusion criteria: * impaired liver function * history of substance abuse or chronic pain * patients known to be hypersensitive to any of the components of caldolor or ofirmev * patients less than 18 years of age. * inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by an institutional review board \[irb\]) and agree to abide by the study restrictions. * be pregnant or nursing * be otherwise unsuitable for the study, in the opinion of the investigator.

Keywords: anesthetics, intravenous
glucagon-like peptide 1 (glp1) receptor agonists and mental health

Conditions: Diabetes Mellitus; Obesity; Mental Health Issue

Summary: this study is investigating the effect of a medication called glucagon-like peptide 1 (glp1) receptor agonists on mental health. glp1 receptor agonists are a type of medication that are used to treat obesity and type 2 diabetes (t2d). obesity and t2d are very common health conditions, and research has shown that people living with obesity and t2d are more likely to experience mental health disorders. some recent research has suggested that glp1 receptor agonists might help with mental health problems such as depression and binge eating disorder, and the investigators want to expand on this in this study. the investigators will be recruiting patients from community diabetes services, and tier 3 weight management services in south east london. patients will be eligible if they are starting on glp1 receptor agonists for the management of either t2d or obesity. the study is a mixed methods, longitudinal observations study with two components - a quantitative and a qualitative aspect. firstly, the investigators will be interviewing patients before and 12-16 weeks after starting the medication, using short questionnaires which asks participants about different mental health symptoms that they may be experiencing. the investigators will use this information to see if there are any objective changes in mental health after taking glp1 receptor agonists. secondly, the investigators will be conducting a longer semi-structured interview after the second set of short questionnaires (at 12-16 weeks after starting glp1 receptor agonist), asking about patient's experiences of taking the medication and how it has affected their mental health and general wellbeing. the investigators will qualitatively analyse this data to determine the subjective effect of glp1 receptor agonists on mental health and wellbeing.


Eligibility criteria:
inclusion criteria: * being commenced on a glucagon-like peptide 1 (glp1) receptor agonist for management of either for obesity or type 2 diabetes * least 18 years of age * able to consent, speak and read in fluent english. exclusion criteria: * not able to consent, speak and read in fluent english
impact of dapagliflozin in anemic chronic kidney disease patients

Conditions: Chronic Kidney Disease(CKD); Anemia, Kidney Disease, Chronic

Summary: dapagliflozin is a sodium-glucose co-transporter 2 (sglt2) inhibitor, primarily used in the management of type 2 diabetes mellitus. emerging research suggests that sglt2 inhibitors may offer additional benefits, including reducing the risk of cardiovascular events and renal complications. post hoc analyses of previous clinical trials have shown that patients treated with sglt2 inhibitors exhibited higher levels of hemoglobin and hematocrit compared to those in the control group. these findings suggest that dapagliflozin's ability to elevate hemoglobin levels could potentially be utilized for the treatment of anemia in patients with chronic kidney disease.


Eligibility criteria:
inclusion criteria 1. adults aged ≥ 18 years with ckd stage iii or iv. 2. patients with anemia of ckd and a hemoglobin level \< 11.5 g/dl 3. patients are receiving erythropoiesis-stimulating agent therapy. exclusion criteria 1. anemia due to causes other than chronic kidney disease, such as pernicious anemia, thalassemia, sickle cell anemia, or myelodysplastic syndromes. 2. patients with severe ketosis, diabetic coma, severe infection, perioperative complications, or severe trauma. 3. patients with acute heart failure, acute myocardial infarction, or stroke occurring within 6 months before enrollment in the trial. 4. patients with current malignancies or a history of malignancy within the past 2 years. 5. diagnosed with pure red cell aplasia. 6. patients with severe gastrointestinal bleeding. 7. pregnant or lactating females.
negative pressure dressing therapy in soft tissue sarcoma surgery

Conditions: Sarcoma; Wound Infection

Summary: this randomised controlled trial aims to evaluate the difference in surgical site infection following excision of soft tissue sarcomas. the intervention is a negative wound pressure therapy dressing for 120 hours, the control is standard absorbent dressings

hypothesis: the application of a negative pressure wound therapy (npwt) dressing will reduce rates of wound breakdown in patients with resection of soft tissue sarcomas which are primarily closed. patients will be randomised into either npwt or standard absorbent dressings with primary outcome measure of surgical site infection according to the health protection agency guidance. secondary outcomes are; time to wound dryness, delayed discharge from hospital, adverse events, cost estimation

Eligibility criteria:
inclusion criteria: * adults undergoing primary soft tissue sarcoma excision which is primarily closed. exclusion criteria: * unable to consent * children * post radiation sarcomas or sarcoma in presence of active infection * multiple metastatic disease * presence of endoprosthesis

Keywords: sarcoma infection negative pressure
surgical guide for thoracic pedicle screw instrumentation in scoliosis correction surgery

Conditions: Scoliosis

Summary: surgical guide for thoracic pedicle screw instrumentation in scoliosis correction surgery


Eligibility criteria:
inclusion criteria: * scoliosis patients exclusion criteria: * none
respiratory muscle strength in patients with nmd

Conditions: Neuromuscular Disease

Summary: the purpose of this study is to determine if inspiratory muscle strength training (imst) will impact maximal inspiratory pressure and pulmonary function in patients with neuromuscular disease.

subjects undergo a 12-week period of inspiratory muscle strength training. respiratory strength is assessed before and after the training period.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of neuromuscular disease * clinical evidence of impaired pulmonary function exclusion criteria: * above or below age range * no clinical evidence of impaired pulmonary function * no diagnosis of a neuromusuclar disease * presence of an acute illness at time of study * participating in other research studies involving investigational drugs * diagnosis of a primary pulmonary disease * use of tobacco products

Keywords: respiratory muscle strength