Kornimate/medical-research-clean huggingface dataset:
time to total hip replacement after supervised exercise and patient education

Conditions: Hip Osteoarthritis

Summary: the purpose of this study is to evaluate the time to total hip replacement in patients with hip osteoarthritis going through both a supervised exercise program and patient education compared to patients going through patient education only. the null hypothesis is: there are no differences in time to total hip replacement between patients with hip osteoarthritis who went through a 12 week supervised exercise program and patient education compared to patients who went through patient education only. material and methods: 109 patients with both symptomatically and radiographically verified hip osteoarthritis were included in this randomized controlled trial between april 2005 and october 2007. they were randomized to either a 12 week supervised exercise program and patient education (n=55) or patient education only (n=54). information on if and when total hip replacement is performed will be collected between april 1st and may 1st. time since inclusion to follow-up will range from 3.5 to 6 years. data will be collected directly from the study participants by telephone. the main outcome is time to total hip replacement. status: this study is a prolongation of an on-going rct (3a-2005-nar) using clinical outcomes to evaluate the effect of supervised exercise and patient education. the study will be carried out: nar-department of orthopedics, ullevaal university hospital.


Eligibility criteria:
inclusion criteria: * between 40 and 80 years old with uni- or bilateral hip disability. * hip pain for more then 3 months. * harris hip score between 60 and 95. harris hip score (0-100 points) is widely used as an assessment of hip function in patients with hip oa. harris hip score of 60 or below are used regularly at our institution as one of the criteria for total hip replacement surgery. * radiographic verified hip oa (danielsson's criteria for radiographic oa: danielsson's criteria for minimal joint space: \< 4 mm \< 70 years, \< 3 mm ≥ 70 years, or 1 mm difference between hips). exclusion criteria: * patients who have a history of resent trauma or functional impairment to the lower limbs or diseases which might interfere with participation (rheumatoid arthritis, cancer, osteoporosis, severe back pain, knee oa). * patients with co-morbidities not tolerating physical activities

Keywords: hip osteoarthritis exercise patient education total hip replacement
may noninvasive mechanical ventilation (niv) and/or continuous positive airway pressure (cpap) increase the bronchoalveolar lavage (bal) salvage in patients with pulmonary diseases?

Conditions: Chronic Obstructive Pulmonary Disease; Interstitial Lung Disease

Summary: the objective of our project is to find procedures and/or parameters to predict the diagnostic recovery (≥ 60% of the administered fluid volume) of bronchoalveolar lavage (bal) fluid before bronchoscopy and to assess the impact of using non-invasive mechanical ventilation (nmv) or continuous positive airway pressure (cpap) to achieve diagnostic recovery in patients with chronic obstructive pulmonary disease (copd) and interstinal lungs disease for whom bal performed during ordinary bronchoscopy turns out to be non-diagnostic.


Eligibility criteria:
inclusion criteria: 1. patients with diagnosed stable copd (stages 1-3) - experimental group; patients with interstitial lung disease - experimental group 2. former and current smokers with normal lung function - potential control group 1; 3. never-smokers with normal lung ventilation - potential control group 2. exclusion criteria: 1. no written, informed consent to participate in the research project. 2. severe respiratory failure (sao2 \< 90%) 3. the patient qualified for home oxygen treatment or home mechanical ventilation 4. severe heart failure (nyha class iv) 5. copd mmrc iv 6. myocardial infarction in the last two weeks or unstable angina 7. severe, particularly ventricular arrhythmias 8. platelet count \< 20,000/ul 9. inr \> 2 or appt \> 36 sec 10. very severe obstruction: forced expiratory volume in 1 second (fev1) \< 30% of predicted.

Keywords: bronchoalveolar lavage noninvasive mechanical ventilation continuous positive airway pressure bronchoscopy
clinical and pathologic studies in neuroendocrine tumors

Conditions: Carcinoid Tumor; Neuroendocrine Tumors

Summary: this research involves the study of neuroendocrine tumors in order to better understand how the disease grows and spreads. this study requires will use tissue collected from from biopsies performed during your regular medical care (i.e. tissue leftover after your diagnosis has been made) and/or blood and urine samples. this study may lead to the development of special materials that could be used, in the future, to treat neuroendocrine tumors or to follow the response of neuroendocrine tumors to treatment


Eligibility criteria:
inclusion criteria:- patients are eligible if they have a histologically proven neuroendocrine tumor and are 18 years of age or older - ability to understand and the willingness to sign a written informed consent document. exclusion criteria:none
catheter salvage in intestinal failure patients

Conditions: Intestinal Failure; Catheter-Related Bloodstream Infection (CRBSI) Nos

Summary: this is an observational study evaluating a catheter salvage strategy in relation to catheter-related bloodstream infections in patients with chronic intestinal failure dependent on home parenteral support. the study is confined to the period 2002 to 2016.

in chronic intestinal failure patients receiving home parenteral support (hps), catheter-related bloodstream infections (crbsis) frequently results in replacement of their tunneled central venous catheters (cvcs) which may lead to future loss of central venous access. this observational study investigates the consequences of a catheter-salvage-strategy related to crbsis according to different causative microorganisms, and short- and long-term risk of recurrence of the crbsi. the study is based on the copenhagen intestinal failure database, which is a web-based database with retrospective data collection performed by reviews of medical charts from all adult intestinal failure patients discharged with home parenteral support from the department of medical gastroenterology, rigshospitalet.

Eligibility criteria:
inclusion criteria: * chronic intestinal failure dependent on home parenteral support and enrolled in the copenhagen intestinal failure database exclusion criteria: * never discharged on home parenteral support

Keywords: intestinal failure catheter-related bloodstream infections catheter salvage recurrent infections home parenteral support
natural history of medullary thyroid cancer to inform advanced disease management

Conditions: Advanced Thyroid Gland Medullary Carcinoma; Stage III Thyroid Gland Medullary Carcinoma AJCC v8; Stage IV Thyroid Gland Medullary Carcinoma AJCC v8; Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8; Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8; Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8

Summary: this study utilizes a multi-institutional registry to describe the natural history of medullary thyroid cancer that has spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) in understanding disease management. the goal of this study is to learn about how medullary thyroid cancer develops and progresses.

primary objectives: i. to describe the natural history of medullary thyroid cancer (mtc) using a comprehensive battery of demographic, clinical, pathologic, and genotypic variables collected in our existing multi-institutional patient registry. ia. to describe the demographic, clinical, pathologic, and genotypic variables associated with each phase of disease. ib. to identify those variables which are predictors of progression to the most advanced phases of disease that require small molecule therapy, including commercially approved and experimental agents. ii. to characterize patients' experience with the different phases of mtc through a systematic evaluation of patient-reported outcomes (pros). iia. to describe clinical, psychosocial, economic, and physical well-being variables and the subsequent impact on quality of life associated with each phase of disease. iib. to evaluate longitudinal changes in clinical, psychosocial, economic, and physical well-being variables between and within all phases of mtc, and the subsequent impact they have on quality of life. iii. to evaluate the association of selected biometric and patient-reported outcomes on adherence, change, and discontinuation of approved targeted therapies and drugs being tested within clinical trial. outline: aim i \& ii: patients complete questionnaires over 10-40 minutes 2-4 times per year about health and how finances and quality of life effect experience with disease. aim iii: patients complete a questionnaire over 2 minutes and undergo blood pressure measurements every day for up to 12 weeks. the questionnaire data gets paired with the collected medical record history that is maintained in the registry.

Eligibility criteria:
inclusion criteria: * aims 1 and 2: a diagnosis of mtc * aims 1 and 2: a registrant in the medullary thyroid cancer registry (mtcr). patients of all disease phases will be eligible for enrollment * aim 3: a diagnosis of advanced phase (red or gray) mtc as determined by clinical team * aim 3: a current registrant in the mtcr
efficacy of songling xuemaikang capsules on grade 1 hypertension: a randomized controlled trial

Conditions: Hypertension,Essential

Summary: the purpose of this study is: 1. to evaluate the efficacy of songling xuemaikang capsules(slxmkc) with grade 1 hypertension. 2. to reveal the potiential effects of slxmkc on vascular function and structure of patients with grade 1 hypertension. 3. to explore the underlying mechanisms of the therapeutic effects of slxmkc on the intervention of grade 1 hypertension.


Eligibility criteria:
inclusion criteria: * age between 35-65 years old, male or female; * grade 1 essential hypertension; * taking no antihypertensive drugs or taking antihypertensive drugs irregularly in the past ; * sign the informed consent; exclusion criteria: * significant liver and kidney dysfunction, alt and ast upper the twice of normal range, scr≥2.0mg/dl, egfr\<60ml/(min·1. 73m2); * gastrointestinal diseases, which may affect drug absorption; * be allergic to the clinical trial medicine; * pregnant or breastfeeding women, men who plan to give birth within half a year; * combined with other serious primary diseases or malignant tumors; * hyperlipidemia with or without taking lipid-lowering drugs; * combined with left ventricular hypertrophy, abi \< 0.9, cimt ≥ 0.9mm or atherosclerotic plaque; * hypertensive comorbidities (cerebrovascular disease, other cardiovascular diseases, renal disease, peripheral artery disease, retinopathy, diabetes); * other serious conditions in which is not fit for the study.

Keywords: songling xuemaikang capsules vascular remodeling grade 1 hypertension mild hypertension
the investigation of exercise capacity and exercise-induced fatigue in young adults who survived from coronavirus

Conditions: Covid19

Summary: the effects of coronavirus disease (covid-19), a multisystem disease, on the body system and functions are being investigated all over the world. examining the effect of exercise capacity, which is an important marker of cardiovascular risk in young individuals with covid-19, will allow the planning of exercise and physical activity programs according to the needs of that specific population. the objectives of this project are:(1) to compare the submaximal and maximal exercise capacity of young adults aged between 18-30 who have had covid-19 with healthy individuals in the same age group (2) to determine the roles of muscle strength, respiratory functions, fatigue, dyspnea, and physical activity level on exercise capacity evaluated by two different tests in young adults survived from covid-19.

the effects of covid-19, a multisystem disease, on the body system and functions are being investigated worldwide. for young adults, exercise capacity is vital in the workforce, cardiovascular risk factors and long-term health perception. determining exercise capacity, which is an essential indicator of cardiovascular risk in the long term, and determining the factors affecting exercise capacity in cases with covid-19 will allow the planning of exercise and physical activity programs according to young people's needs. the objectives of this project are:(1) to compare the submaximal and maximal exercise capacity of young adults aged between 18-30 who have had covid-19 with healthy individuals in the same age group (2) to determine the roles of muscle strength, respiratory functions, fatigue, dyspnea, and physical activity level on exercise capacity evaluated by two different tests in young adults survived from covid-19. there is no study in the literature evaluating the exercise capacity and the factors affecting the prolonged covid-19 symptoms for patients with covid-19. this project can provide objective evidence on this subject and includes controlled multi-directional measurement.

Eligibility criteria:
inclusion criteria: * for cases with covid-19: confirmed covid-19 infection - for healthy individuals of the same age group who have not had covid-19: individuals who have not been diagnosed with covid-19 as of march 11, 2020 and who have not been in contact and risky according to the "life fits into home" application - for all participants; answering "no" to all questions in the physical activity readiness questionnaire. exclusion criteria: * individuals with orthopedic or neurological disabilities that may interfere with exercise testing, * individuals with a fever\> 38 ° c and / or resting blood pressure \ 140/90 mmhg and/or oxygen saturation ≤95%, * individuals who have been involved in a physiotherapy and rehabilitation program within the last 3 months, * individuals with insufficient cooperation * individuals with blood coagulation disorders contraindicated for blood lactate analysis, * pregnant women or individuals with suspected pregnancy

Keywords: coronavirus exercise capacity
a study of qls31905 in patients with advanced solid tumors

Conditions: Advanced Solid Tumors

Summary: this is a multi-center, open-label design to evaluate the safety and tolerance of qls31905 in patients with advanced solid tumors, together with an assessment of pharmacokinetic characteristics and efficacy.


Eligibility criteria:
inclusion criteria: 1. written informed consent. 2. ≥18 years. 3. female or male. 4. ecog performance status score 0 or 1. 5. histologically or cytologically confirmed diagnosis of advanced solid tumors. 6. adequate haematological, hepatic and renal function. exclusion criteria: 1. any anticancer therapy or immunotherapy within 4 weeks prior to the start of study treatment. 2. untreated or symptomatic central nervous system (cns) metastases or leptomeningeal disease. 3. patients with a history of monoclonal antibody allergic reaction. 4. known human immunodeficiency virus infection or known symptomatic hepatitis.
iliac vein stenting and compression therapy in recurrent venous ulceration

Conditions: Venous Ulcer Recurrent

Summary: comparing the result of of iliac vein stenting and compression therapy in management of recurrent venous ulceration.

venous ulceration is the most common etiology of lower extremity ulceration, approximately affecting almost 1% of the world's population. although its overall prevalence is relatively low, the refractory nature of venous ulceration increases morbidity, mortality , the patient's quality of life, and have a significant financial burden on the global budget. the primary risk factors are: old age, obesity deep venous thrombosis, phlebitis and previous leg injuries. iliac vein compression is a prevalent finding in patients with venous system pathology. it has a variety of causes, including may-turner syndrome, endometriosis, bladder distension, common iliac artery aneurysm or internal iliac artery aneurysm. venous compression becomes clinically significant when there's an increase in venous pressure, which in turn causes venous insufficiency. this contributes to the development of a state of chronic venous stasis, which sequentially causes pooling of blood, triggers further capillary damage and activates inflammatory mediators with the end result of venous ulcer development and impaired wound healing. located on bony prominences, venous ulcers are typically shallow, irregular with granulation tissue and fibrin present in their bases. a careful physical examination is required for a proper diagnosis, but he clinical challenge remains in its management, which includes prevention or the treatment of the clinical implications. treatment modalities should always be directed to the cause of the ulcer; they can be divided into: * non invasive management, such as medical therapy, bandaging and dressings. * invasive, such as endovascular and surgical techniques.

Eligibility criteria:
inclusion criteria: * iliac vein compression. * competent superficial venous system. * isolated iliac vein lesion. * patent femoropopliteal segment. * ulcers located in the gaiter area. * age \> 12 years * patients with ulcers located in the gaiter area, along with the following associated symptoms: leg heaviness, pain, varicose veins, edema, hemosedrin staining, pruritus, venous dermatitis, lipodermatoscelrosis, telangiectasias, corona phlebectatica, atrophie blanche and deformity of the leg. exclusion criteria: * patients with arterial disease in the same limb. * patients with history of phlebitis. * patients with congenital venous malformation * patients with malignancy. * patients with raised renal chemistry. * patients with skin allergy. * diabetic neuropathic ulcer. * atypical site of venous ulcer. * acute onset dvt. * age \< 12 years.
a comparison of safety and treatment in subjects with osteoarthritis taking low dose aspirin

Conditions: Osteoarthritis; Peptic Ulcer

Summary: the purpose of this study is to compare the gastroduodenal ulceration rate, gastrointestinal complication rate and non-steroidal anti-inflammatory drug-associated dyspepsia between lansoprazole, naproxen and celecoxib, taken once daily (qd) or twice daily (bid), in participants with osteoarthritis taking low dose aspirin.

this study was designed to compare the effectiveness of reducing the incidence of gastroduodenal ulcers between lansoprazole 30mg qd + naproxen 500mg bid vs celecoxib 200mg qd in subjects with osteoarthritis taking low dose aspirin. approximately 100 sites across the u.s. will enroll subjects with normal endoscopic findings and negative h.pylori. the duration of the study will be a maximum of 14 weeks including a screening period of up to 2 weeks and a 12 week treatment period. gelusil will be provided for dyspepsia symptom rescue.

Eligibility criteria:
inclusion criteria: * must require the chronic use of a non-steroidal anti-inflammatory drug for the treatment of osteoarthritis. * must be taking daily aspirin for cardiovascular prophylaxis. * clinical laboratory values within normal limits for this population exclusion criteria: * history of gastric, duodenal or esophageal surgery except simple oversew of an ulcer. * evidence of uncontrolled, clinically significant disease. * history of cancer within the past 5 years. * presence of gastroduodenal ulcers, esophageal ulcer or \>= 10 gastroduodenal erosions during the screening endoscopy. known history of gastroduodenal ulcer or bleeding within the past year. esophageal stricture requiring dilatation. * presence of barrett's esophagus with dysplastic changes. * systemic disease affecting the esophagus or a history of caustic or physiochemical trauma or irradiation to the esophagus. * sero-tests positive for h. pylori. * evidence of zollinger-ellison syndrome, esophageal varices, cholecystitis, or pancreaticobiliary tract disease. * requires treatment with an excluded medication such as proton pump inhibitors, histamine h2 receptor antagonists, antacids, corticosteroids, lithium, fluconazole, misoprostol, probenecid, methotrexate, anticoagulants, st. john's wart, dong quai, feverfew, garlic, ginger, horse chestnut, red clover or white willow supplements or bisphosphonates.

Keywords: low dose aspirin peptic ulcer gastric ulcer duodenal ulcer nsaids
dose-ranging study of a006 dpi, in adult asthma patients

Conditions: Asthma; Bronchospasm

Summary: this study is a randomized, active- and placebo-controlled, single-dose, seven-arm, crossover and dose-ranging design. this study aims to evaluate the efficacy and initial safety profiles, and to identify the optimum dose of a006, from a select dose-range for future clinical pk/pd and phase iii studies. this study is to be conducted in generally healthy, adult subjects who have mild-to-moderate persistent asthma for at least 6 months prior to screening.


Eligibility criteria:
inclusion criteria: * with mild-to-moderate persistent asthma for at least 6 months and having used inhaled beta-agonist for asthma control; * must demonstrate response to beta 2 agonist by reversing; * must demonstrate ability to use dpi; * females of child-bearing potential must be non-pregnant, non-lactating, and practicing a clinically acceptable form of birth control; * additional criteria exclusion criteria: * smoking history of ≥ 10 pack-years, or having smoked within 6 months; * upper respiratory tract infections * asthma exacerbations; * known intolerance or hypersensitivity to any of the ingredients of the study drug or proventil®; * use of prohibited drugs or failure to observe the drug washout restrictions; * having been on other clinical drug/device studies in the last 30 days; * other criteria

Keywords: asthma bronchospasm copd chronic respiratory disease
electroencephalography in the management of neuroelectric stimulation in patients with severe traumatic brain injuries

Conditions: Brain Injuries

Summary: the goal of this observational retrospective study is to evaluate the electroencephalography (eeg)'s poficiency in the treatment of neuroelectric stimulation in patients with severe traumatic brain injuries (tbi). the main questions it aims to answer are: 1. whether eeg of patients with severe tbi will change after they receiving neuroelectrial stimulation? if yes, how does it change? 2. how can eeg be used to evaluate the condition of patients with severe tbi?


Eligibility criteria:
inclusion criteria: * 7 days after severe traumatic brain injuries (gcs score 3-8); * over 18 years old, regardless of gender; * the patient's legal representative is informed and voluntarily signs the consent form. exclusion criteria: * unstable vital signs; * history of mental disorders or neurodegenerative diseases; * uncontrolled epilepsy; * severe arrhythmias or patients with implanted cardiac pacemakers; * various conditions that interfere with scalp eeg collection; * pregnant women.

Keywords: electroencephalography severe traumatic brain injuries