Kornimate/medical-research-clean huggingface dataset:
a study in patients with braf v600e-mutant metastatic non-small cell lung cancer (octopus)

Conditions: Metastatic Non-small Cell Lung Cancer; BRAF V600 Mutation

Summary: this study aims to describe the treatment patterns in clinical practice in adult patients with mnsclc with a braf v600e mutation. this study will also describe real-world progression-free survival (rwpfs) and overall survival (os) for treatments prescribed in routine practice for mnsclc with braf v600e mutation. adverse events (aes) related to treatment management will also be described.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years at the time of first-line treatment initiation for mnsclc, * patients who initiated a first systemic treatment for mnsclc in the metastatic setting from 01 december 2017 and before their study entry date (retrospectively enrolled patients), or patients who initiated a first systemic treatment for mnsclc (metastatic setting) at or after their study entry date (prospectively enrolled patients), * confirmed diagnosis of stage iv mnsclcat any time before study inclusion stage iv m1a, m1borm1c, as per the american joint committee on cancer (ajcc cancer) staging manual, * confirmed presence of braf v600e mutation - via tumor biopsy, metastasectomy, or liquid biopsy - at anytime before study inclusion, * signed icf or non-opposition to study participation,according to local regulations. patients eligible for prospective qol data collection must, in addition to the above mentioned criteria, meet all of the following criteria to be eligible for the study: * patients who initiate a first or second systemic treatment line for mnsclc (metastatic setting) with a braf v600e mutation at or after their study entry date exclusion criteria: * concurrent or another previous malignancy within 2 years of study entry, except curatively treated basal or squamous cell skin cancer, prostate intraepithelial neoplasm, in-situcarcinoma of the cervix, bowen's disease or gleason ≤ 6 prostate cancer, * previous, ongoing, or planned participation in a clinical trial involving an interventional drug as a first-or second-line systemic treatment for mnsclc.

Keywords: metastatic non-small cell lung cancer braf v600 mutation
cerebrovascular dysregulation in chronic kidney disease

Conditions: Chronic Kidney Diseases

Summary: the purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (ckd).

prior research has shown that ckd patients have an increased risk of stroke and that impairments in brain blood flow regulation predict stroke in other chronic disease states. this study will test whether exercise training can improve brain blood flow regulation via improved dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity in ckd. participants will undergo exercise training on a stationary bicycle, or stretching exercises, 3 times per week for 12 weeks.

Eligibility criteria:
inclusion criteria: • individuals with chronic kidney disease stages iii-iv. exclusion criteria: * heart failure * chronic obstructive pulmonary disease * uncontrolled hypertension or hypotension * pregnancy or plans to become pregnant * inability to exercise on a stationary bicycle * current participation in exercise more than 20 minutes twice per week

Keywords: exercise brain blood flow
patient buddy app for the prevention of avoidable readmission in cirrhosis

Conditions: Cirrhosis

Summary: to use the patientbuddy app to reduce 30-day avoidable readmissions in cirrhotic patients using a patient and caregiver perspective.

specific aim 1: to perform a pilot and feasibility study of disseminating current knowledge of readmission prevention in cirrhosis by using the patient buddy app with patient and caregiver interfaces. eighty subjects (40 cirrhotic inpatients and 40 caregivers) will be enrolled and trained on the patient buddy at discharge. the app focuses on daily communication between patient/caregivers and the study team based on previously identified risk factors associated with readmission. the study team will initiate measures to prevent readmission using these communications. a detailed analysis of 30-day readmissions and input of the patients,caregivers and nurse manager will be performed to improve the app. avoidable readmissions will be defined by a committee of hepatologists who is not part of the study at vcu. specific aim 2: to incorporate the opinion of key stakeholders (patients, caregivers and case managers) towards improving the patient buddy app in the prevention of avoidable readmission in cirrhosis. the input of the key stakeholders and the analysis of readmissions prevented during the pilot study will be used to update the app for preventing avoidable readmissions in future studies

Eligibility criteria:
inclusion criteria: * cirrhosis patients ≥21 years of age hospitalized for non-elective reasons * adult caregiver and the patient living in the same house * both (caregiver and patient) should be able to complete the patient buddy training and evaluation * discharged home from the hospital * patients who have vcu as a primary hospital base exclusion criteria: * elective hospitalization * lack of an adult caregiver * active alcohol/substance abuse within 1 month of the hospitalization * unable to perform training or give consent * patients discharged to hospice, nursing home or extended care facilities * patients on hemodialysis
success and color stability of mta pulpotomized primary molars: an rct

Conditions: Reversible Pulpitis; Dental Pulp Diseases

Summary: mineral trioxide aggregate has been previously fda approved as an endodontic filler. its use in vital teeth has demonstrated significant color change post-treatment leaving it ineffective for esthetic use.. the new formulation will be tested to see if has the same effect.

this randomized control, split-mouth trial will use 50 pediatric subjects selected from the patient population in the pediatric dental clinics at baylor college of dentistry and in select faculty private practices. the study will use a within-subject control design whereby one tooth will be treated with a pulpotomy using the new formulation of mta (neomta plus, avalon biomed inc., bradenton, fl, usa) and restored with a multi-surface composite, and the other tooth with an mta pulpotomy and restored with a ssc; thus, approximately 50 teeth will be treated for each treatment group. the restoration type will be randomized as to which side will receive the ssc or composite using sealed, opaque envelopes. approximately 50 subjects will be needed for the study in order to elicit any significant findings as demonstrated by a power analysis from a similar study.

Eligibility criteria:
inclusion criteria: * • children between the ages of 2 ½ and 8 years of age * patient must have two, contralateral primary molars that are matched for type of molar (first or second), size of carious lesion (same level of approximation of carious lesion to the pulp), and arch (maxillary or mandibular) that are treatment planned for a pulpotomy * the teeth selected for the study must be vital and asymptomatic both clinically and radiographically or only display symptoms consistent with reversible pulptitis * the teeth selected for the study must be anticipated to be retained in the mouth for at least two years * each patient must have an updated medical history form in the dental record, be examined by the operator, and be classified as asa i or ii (in good general health) exclusion criteria: * teeth with a history of spontaneous pain * teeth with radiographic evidence of internal or external resorption, intraradicular or periapical bone loss, loss of lamina dura, or widening of the periodontal ligament space

Keywords: pulp pulpotomies mineral trioxide aggregate
dietary nitrate and physiological aging

Conditions: Aging

Summary: the main purpose/s of this study is to examine the effects of 4 weeks of dietary nitrate supplementation on peripheral chemoreceptor sensitivity, spontaneous baroreflex sensitivity, and blood pressure responsiveness to a variety of physiological stressors in older healthy adults. we will also examine the effect of dietary nitrate supplementation on measures of central artery stiffness and aortic blood pressure in older adults. lastly, we will also recruit a group of young subjects in order to help characterize the age-related changes associated with the physiological outcome measures of the present study.

1 in 3 adults in the u.s. have hypertension which is known to increase the risk of heart disease and stroke. blood pressure regulation is mediated by many factors including but not limited to metabolic factors, pressure/stretch sensing receptors located in the aorta and carotid arteries, endothelial cell function, and kidney function (via water and sodium absorption/excretion). it has been shown that many of these regulatory mechanisms are altered and/or become dysfunctional with aging. specifically older adults commonly demonstrate a decreased sensitivity in pressure receptors and/or endothelial dysfunction. additionally with aging, there is an increase in sympathetic nervous system activity and arterial stiffness which can contribute to higher blood pressure. the important vasodilator, nitric oxide (no), has been implicated as a key signaling molecule involved in several of the mechanisms in blood pressure regulation outlined above. a decreased no production or bioavailability is thought to contribute to several of the physiologic changes that come with aging. therefore, the overall aim of this study is to use a randomized, double-blind crossover, placebo controlled study to examine the effects of acute dietary nitrate supplementation (to boost bioavailable no) on various parameters of blood pressure regulation and responsiveness in normal healthy older adults. our main hypothesis is that 4 weeks of dietary nitrate supplementation will decrease the blood pressure responses in older adults in response to a variety of physiological stressors.

Eligibility criteria:
two separate age groups were included. inclusion criteria: * healthy young adults 18-35 years of age (comparison group) * healthy older adults 60-85 years of age (intervention group) exclusion criteria: * hypertension, hyperlipidemia, current smoker or smoker within the last year, heart disease, diabetes, chronic obstructive pulmonary disease, asthma, sleep apnea, raynaud's disease, body mass index (bmi) \> 30 kg/m2, allergy medication, clinical depression, autonomic disorders and other conditions or medications that might normally alter cardiovascular function, exercise tolerance, and/or blood pressure responses.

Keywords: nitrate blood flow blood pressure vascular function hypoxia
the effects of pxr activation on hepatic fat content

Conditions: Non-alcoholic Fatty Liver Disease

Summary: this study investigates the effects of pregnane x receptor (pxr) activation on hepatic fat content in healthy volunteers. rifampicin (an antibiotic and also an efficient pxr activator) and placebo will be given for a week to volunteers. hepatic fat content is measured with magnetic resonance imaging and blood samples are collected at the end of each study arm. the investigators' hypothesis is that rifampicin causes accumulation of fat to the liver.


Eligibility criteria:
inclusion criteria: * healthy volunteers * body mass index (bmi) 18.5-25 kg/m2 exclusion criteria: * systolic blood pressure over 150 mmhg * any continuous medication (hormonal intrauterine device is permitted) * any significant medical condition * insensitivity to rifampicin * pregnancy and lactation * previous difficult venipuncture * alcohol and medicine abuse and drug use * participation to any other pharmaceutical trial within on month of screening * claustrophobia * metal and other implants which are contraindications to mri
different hemostasis according to the anesthetic agents

Conditions: Cataract; Retina Detachment; Pterygium; Keratitis; Vitreous Hemorrhage

Summary: we investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (rotem) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability more than the sevoflurane-based anesthesia.


Eligibility criteria:
inclusion criteria: * all patient scheduled for ophthalmic surgery under general anesthesia * american society of anesthesiologist physical status i or ii exclusion criteria: * hematologic disorder * severe anemia * liver disease * kidney disease * taking a medication interfering with hemostasis
short-term alpha lipoic acid therapy for prevention of contrast-induced acute kidney injury and endothelial dysfunction in type 2 diabetes

Conditions: Acute Kidney Injury; The Changes of Plasma Creatinine; The Changes of Plasma Free Radicals; The Changes of Endothelium-dependent Arterial Dilation

Summary: contrast-induced acute kidney injury (ciaki) is a major complication with adverse outcomes after contrast media injection. although the risk of developing ciaki is low in patients with normal renal function, it is dramatically higher in patients with conditions such as diabetes mellitus (dm) or chronic kidney disease (ckd). more recently, our data showed that contrast agents can induce endothelial dysfunction partially via free radicals in diabetes. therefore, strategies to prevent ciaki and endothelial dysfunction in dm patients with ckd are urgently needed. alpha-lipoic acid and its reduced form, dihydrolipoate, are potent antioxidants. we hypothesized that alpha lipoic acid can prevent the contrast-induced acute kidney injury and endothelial dysfunction in type 2 diabetes.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * nephropathy (stage 3 and 4) exclusion criteria: * recive alpha lipoic acid * type 1 diabetes * nephropathy (stagte 1, 2 and 5) * hypersensitivity to contrast media * iv heart failure * lactic acidosis

Keywords: type 2 diabetes nephropathy contrast medium alpha lipoic acid
comparison of low-intensity laser and eswt in carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: carpal tunnel syndrome is the most common neuropathy of the median nerve. conservative methods are used in mild and moderate cts in the treatment. in this study, we aimed to compare the effectiveness of low-intensity laser and eswt treatments in patients with mild and moderate carpal tunnel syndrome diagnosed with emg.

carpal tunnel syndrome is the most common neuropathy of the median nerve. its incidence increases between the ages of 40-60. its prevalence is 4-5%, and incidence is 2.7%. it is more common in women than men. the vast majority of cases are idiopathic.the first symptoms usually start at night. the patient wakes up with a feeling of swelling without any visible swelling and symptoms such as burning, numbness and tingling in the median nerve region.in severe cases, hand weakness and thenar atrophy develop. provocative tests such as phalen, reverse phalen, tinel, carpal compression test, tourniquet test can be used in the examination.the diagnosis of carpal tunnel syndrome is made by nerve conduction studies and electromyography. conservative methods are used in mild and moderate cts in the treatment. surgical methods are recommended in severe cases and in cases unresponsive to conservative treatment.one of the methods used in the treatment is laser (light amplification by stimulated emission of radiation).there are low and high intensity laser applications according to their energy densities. the basic mechanism of action is tissue stimulation. eswt (extracorporeal shock wave therapy), another treatment method, shows therapeutic properties by focusing high-amplitude sound waves on the desired area of the body. apart from the mechanical effect, it also has an effect at the cellular level.in previous studies, both low-intensity laser and eswt application were found to be effective in the treatment of carpal tunnel syndrome. however, as far as we know, there is no study comparing the efficacy of low-intensity laser therapy and eswt therapy in carpal tunnel syndrome. in this study, we aimed to compare the effectiveness of low-intensity laser and eswt treatments in patients with mild and moderate carpal tunnel syndrome diagnosed with emg.

Eligibility criteria:
inclusion criteria: * 18-65 years * having a clinic compatible with carpal tunnel syndrome, * patients with electrophysiological data compatible with mild and moderate carpal tunnel syndrome exclusion criteria: * cervical radiculopathy , polyneuropathy , brachial plexopathy , thoracic outlet syndrome * regular use of oral steroids or nsaii in the last 3 months * systemic disease (dm, hypothyroidism, ra, gout, acromegaly, ckd, dialysis) * severe carpal tunnel syndrome (kts)

Keywords: carpal tunnel syndrome extracorporeal shock wave therapy laser treatment
clinical study evaluating two treatment protocols for immunosuppressive drugs. looking at 3-year incidence of clad.

Conditions: Lung Transplantation; Allografts

Summary: a controlled randomized, open-label, multi-centre study evaluating if an immunosuppressive protocol, based on atg-induction, once daily tacrolimus-dose (advagraf®), mycophenolate mofetil and corticosteroid reduces the incidence of chronic lung allograft dysfunction (clad) after lung transplantation, in comparison with a standard cyclosporin-based protocol.

study purpose: to evaluate whether the use of a once-daily tacrolimus-dose regimen (advagraf®), based on anti-thymocyte globulin (thymoglobulin®) induction, mycophenolate mofetil (mmf) and corticosteroids, reduces the cumulative incidence of clad after de novo lung transplantation at 36 months, in comparison with a twice-daily cyclosporin-based protocol, otherwise identical between groups.

Eligibility criteria:
inclusion criteria 1. male or female lung recipients 18-70 years of age undergoing primary double (including size reduction) lung transplantation. 2. patient willing and capable of giving written informed consent for study participation and anticipated to be able to participate in the study for 36 months. exclusion criteria 1. recipients of multiorgan transplant, and or previously transplanted with any organ, including previous lung transplantation. 2. patients with hypersensitivity to, or other reasons to not be able to take the immunosuppressive drugs used in the study. 3. donor lung cold ischemic time \> 12 hours. 4. patients who previously have been treated with anti-thymocyte globulin preparations (e.g. atg-fresenius®, thymoglobulin®). 5. patients who are recipients of abo-incompatible transplants. 6. patients with platelet count \< 50,000/mm3 at the evaluation before transplantation. 7. patients who are unlikely to comply with the study requirements. 8. patients, and/or those receiving organs from donors, who are positive for hiv, hepatitis b surface antigen or hepatitis c virus. 9. patients with donor greater than 75 years. 10. patient who have received an unlicensed drug or therapy within one month prior to study entry or if such therapy is to be instituted post-transplantation. 11. patient unable to participate in the study for the full 36-month period 12. patients with any past (within the past 3-5 years) or present malignancy (other than excised basal cell carcinoma). 13. females capable of becoming pregnant must have a negative pregnancy test prior to randomization. females are recommended to practice a medically approved method of birth control for the duration of the study and a period of 8 weeks following discontinuation of study medication, even where there has been a history of infertility

Keywords: chronic lung allograft dysfunction cyclosporin tacrolimus bronchiolitis obliterans syndrome restrictive allograft syndrome clad immunization renal function survival
effect of pilates exercises and diaphragm manual therapy techniques in rotator cuff tendinopathy

Conditions: Shoulder Tendinitis; Shoulder Rotator Cuff Tendinopathy

Summary: 1. to investigate the effect of pilates exercises program on pain intensity, pain threshold, shoulder lateral rotator strength, abduction strength and shoulder function in patients with (rct). 2. to investigate the effect of diaphragm manual therapy techniques on pain intensity, pain threshold, shoulder lateral rotator strength, abduction strength and shoulder function in patients with (rct). 3. to determine the effect of combination between pilates exercises program and diaphragm manual therapy techniques on pain intensity, pain threshold, shoulder lateral rotator strength, abduction strength and shoulder function in patients with (rct).

musculoskeletal complains are common work-related problems in egypt. egyptian preparatory school teachers were 96%. dental society revealed high response rate (93%) with 53.8% have complains related to neck/shoulder .physical therapists (pts) are frequently exposed to work-related musculoskeletal disorders .shoulder problems represent (47.7%).printing workers and municipal solid waste collectors are another group having high prevalence of work-related musculoskeletal disorders that might be related to some individual factors (age, bmi, and duration of employment). since pilates shoulder exercise influence shoulder function and pain and to considering the relationship between shoulder muscles and the thoracic cage expansion. consequently, it is worthy to investigate the efficacy of pilates exercises program with diaphragm manual therapy techniques in pain intensity, pain threshold, shoulder lateral rotator strength, abduction strength and shoulder function on patient with rotator cuff tendinopathy aiming for function improvement and pain decrease. therefore, this study is being conducted for this purpose.

Eligibility criteria:
inclusion criteria: 1. patients diagnosed with rotator cuff tendinopathy for duration greater than three months 2. body mass index between 18.5 and 24.9 3. patients complain of shoulder pain at the tip of the shoulder and the upper, outer arm. 4. pain during resisted arm test (usually abduction and/or lateral rotation) ( exclusion criteria: * 1. shoulder stiffness 2. previous dislocation or sublation of shoulder joint. 3. previous shoulder surgery 4. glenohumeral joint and acromioclavicular joint degeneration 5. neurological deficit in the neck or arm 6. heavy smokers. 7. any cardiopulmonary pathology. 8. recent thoracic surgery 9. any deformity of spine 10. history of thyroid disorders 11. cognitive impairment

Keywords: shoulder tendinitis shoulder rotator cuff tendinopathy pilates exercise diaphragmatic respiratory technique physical therapy
the aim of this study is to demonstrat that vacuum-assisted closure versus conventional wound closure enables to diminish local complications after lymph node dissection in patients with metastatic skin tumors

Conditions: Melanoma; Skin Cancer; Epidermoid Carcinoma; Neuroendocrine Carcinoma; Lymph Node Metastases

Summary: in this study, we compared a negative pressure wound therapy, versus a conventional dressing in order to evaluate the most efficient wound therapy closure after axillary and inguinal lymph nodes dissections in the management of metastatic skin tumors. a vacuum assisted closure therapy should prevent these comorbidities.

lymphorrhoea, lymphedema and lymphocyte are significant and common complications after axillary and inguinal lymph nodes dissections. a vacuum assisted closure therapy should prevent these comorbidities. in this study, we compared prevena, a negative pressure wound therapy, versus conventional dressings. we evaluated the wound complications at the seventh day, the thirtieth day and at this end of the first year after surgery. it is a retrospective study of about ninety lymph nodes dissections among with there were seventy times the use of a negative pressure wound therapy, prevena.

Eligibility criteria:
inclusion criteria: * major patient affected by a metastatic skin tumors * the primitive skin tumor is either a mélanoma, either squamous cell carcinoma , or a neuroendocrine tumor exclusion criteria: * lymph node dissection resumption

Keywords: vacuum assisted closure preneva lymph node dissection