Kornimate/medical-research-clean huggingface dataset:
prevention of skeletal muscle adaptations to traumatic knee injury and surgery

Conditions: Anterior Cruciate Ligament Reconstruction

Summary: traumatic knee injury is common and highly debilitating. surgical reconstruction/repair improves knee biomechanics and function, but neuromuscular dysfunction persist for years despite rehabilitation, hindering resumption of normal activities, increasing risk of further injury and, in a majority of patients, hastening the development of knee osteoarthritis (oa). our goal in this research study is to evaluate the utility of neuromuscular electrical stimulation (nmes), initiated following injury and maintained through the early post-surgical period, to prevent muscle atrophy and intrinsic contractile dysfunction compared to active control intervention of micro-electrical stimulation.


Eligibility criteria:
inclusion criteria: * 18-50 yrs * bmi \<35 kg/m2 * acute, first-time, acl rupture with or without meniscus injury * scheduled to undergo reconstruction with a bptb autograft exclusion criteria: * history of prior knee/lower extremity surgery or non-surgical intervention (eg, intra-articular injection) on either leg * abnormal laxity of any lower extremity ligament other than the injured acl * signs or symptoms of arthritis, autoimmune or inflammatory disease or diabetes * grade iiib or greater articular cartilage lesions (icrs criteria) * women who are/plan on becoming pregnant
a study of subcutaneously administered tocilizumab in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this open-label randomized 2arm study will investigate the pharmacokinetics, pharmacodynamics, efficacy and safety of subcutaneously administered tocilizumab in patients with rheumatoid arthritis who have shown an inadequate response to methotrexate. patients will be randomized to receive tocilizumab 162 mg sc either weekly or every other week, in combination with methotrexate, for 12 weeks. assessments will be made at regular intervals during treatment and on the 3 weeks of follow-up.target sample size is \< 50 individuals.


Eligibility criteria:
inclusion criteria: * adults 18 - 75 years of age * active rheumatoid arthritis of \>/= 6 months duration * inadequate response to at least 12 weeks of methotrexate, the last 8 prior to baseline on stable dose * swollen joint count (sjc)\>/=4, tender joint count (tjc)\>/=6 at screening and baseline * dmards and anti-tnfs, other than methotrexate, withdrawn prior to baseline * oral corticosteroids (\</= 10mg/day prednisone or equivalent) and nsaids on stable dose \</= 4 weeks prior to baseline exclusion criteria: * rheumatic autoimmune disease other than rheumatoid arthritis * prior history or current inflammatory joint disease other than rheumatoid arthritis * major surgery (including joint surgery) within 8 weeks prior to screening or planned major surgery within 6 months following enrollment * functional class iv by acr classification
evoked retinal response

Conditions: Retinitis Pigmentosa

Summary: retinitis pigmentosa (rp) is the name given to a group of inherited eye diseases that affect the retina (the light-sensitive part of the eye). rp causes the breakdown of photoreceptor cells (cells in the retina that detect light). photoreceptor cells capture and process light helping us to see. as these cells breakdown and die, people experience progressive vision loss. there is no known cure for retinitis pigmentosa. the investigators have observed that short pulses of focused ultrasound can cause perception of light when directed to spots on the retinal surface. the investigators propose to conduct a study to determine if pulsed ultrasound will stimulate the perception of light in the absence of functional photoreceptors in people with rp

patients affected by retinitis pigmentosa (rp) and related diseases suffer loss of vision due to death of photoreceptor cells. the investigators have observed that short pulses of focused ultrasound can cause perception of light (phosphenes) when directed to spots on the retinal surface. if this phenomenon is caused by direct stimulation of the retinal nerves, which seems probable, then it might be possible to use this phenomenon to produce a form of vision in such patients. the investigators propose to conduct a study of a small cohort of patients affected by rp to determine if pulsed ultrasound will evoke a perception of light in the absence of functional photoreceptors.

Eligibility criteria:
inclusion criteria: * retinitis pigmentosa * legally blind in at least one eye exclusion criteria: * unable to lay down on an exam table

Keywords: retinitis pigmentosa acoustic radiation force ultrasound rp visual field loss photoreceptor vision loss retina progressive vision loss ultrasound
safety, tolerability, and antiviral activity of ana598 in patients with genotype-1 chronic hcv infection

Conditions: Chronic Hepatitis C

Summary: the purpose of this study is to investigate the safety, tolerability, and antiviral activity of ana598 in patients with genotype-1 chronic hepatitis c infection.

the safety, tolerability and antiviral activity of ana598, administered orally twice daily for 3 days, will be compared to placebo in treatment-naïve subjects chronically infected with hcv genotype 1 infection. thirty (30) subjects will be randomized to one of three cohorts described above. the ten patients in each cohort will be randomized 8 active: 2 placebo. at least 5 subjects with genotype 1a and 5 subjects with genotype 1b will be enrolled within each cohort.

Eligibility criteria:
inclusion criteria: * male or female, ages 18 to 65 years * documented chronic hcv infection, genotype 1a or 1b * treatment-naïve * bmi = 18 - 35 kg/m2 exclusion criteria: * female patients who are pregnant or breast-feeding * previous treatment for hcv infection * hiv or hbv positive * evidence of cirrhosis on previous liver biopsy or on previous imaging studies * history of any other known cause of liver disease;

Keywords: hcv
intravascular volume assessment using ultrasonography in pediatrics renal transplant: a prospective cohort study

Conditions: Chronic Kidney Failure

Summary: this study is designed for volume assessment in pediatrics during major surgery using non-invasive tools as ultrasonography without the need of invasive techniques avoiding its complications and as a guide for fluid therapy needed for maintaining adequate hemodynamics

intravascular volume assessment during surgery is important for maintaining adequate hemodynamics. methods approved for volume assessment include the use of echocardiography to measure left ventricular end diastolic area (lveda), central venous pressure (cvp) and pulmonary artery diastolic pressure (pad). lveda is considered the good predictor for volume status assessment. cvp and pad are invasive can potentially subject the patient to complications. recently study performed an ultrasound assessment of the internal jugular vein (ijv) as a useful means of volume status assessment intraoperative under general anesthesia. in the pediatric population, only few studies are carried out to assess the use of ultrasound for intravascular volume assessment. this study will evaluate use of ultrasonography of ijv in volume assessment in pediatrics will undergo renal transplant surgery and correlate ijv diameter, cross sectional area to cvp and lveda.

Eligibility criteria:
inclusion criteria: * pediatric patients with end stage renal disease * weight between: 12 to 30 kg exclusion criteria: * infection at the site of cvp or generalized infection. * ijv thrombosis

Keywords: volume assessment
effect of allopurinol on mono and co-administration with statins on platelets reactivity on diabetic patiets treated with aspirin and insulin

Conditions: Diabetes Mellitus Type 2 Platelets Reactivity Statin

Summary: diabetes mellitus is associated with an increased risk of cardiovascular disease. substantial clinical and experimental evidence suggest that both diabetes and insulin resistance cause a combination of endothelial dysfunctions, which may diminish the anti-atherogenic role of the vascular endothelium. therefore, in patients with diabetes or insulin resistance, endothelial dysfunction may be a critical early target for preventing atherosclerosis and cardiovascular disease. it has been implicated as an independent risk factor for cardiovascular disease and premature cardiovascular mortality for patients with type 1 and type 2 diabetes mellitus, as well as for patients with essential hypertension. a complete biochemical understanding of the mechanisms by which hyperglycemia causes vascular functional and structural changes associated with the diabetic milieu still eludes us. in recent years, the numerous biochemical and metabolic pathways postulated to have a causal role in the pathogenesis of diabetic vascular disease have been distilled into several unifying hypotheses. the role of chronic hyperglycemia in the development of diabetic microvascular complications and in neuropathy has been clearly established. however, the biochemical or cellular links between elevated blood glucose levels, and the vascular lesions remain incompletely understood. a number of trials have demonstrated that statins therapy as well as angiotensin converting enzyme inhibitors is associated with improvements in endothelial function in diabetes. although antioxidants provide short-term improvement of endothelial function in humans, all studies of the effectiveness of preventive antioxidant therapy have been disappointing. actually, control of hyperglycemia thus remains the best way to improve endothelial function and to prevent atherosclerosis and other cardiovascular complications of diabetes.


Eligibility criteria:
inclusion criteria: * diabetic patient; * therapy with aspirin and insulin; * patient well responders exclusion criteria: * not diabetic patient; * patients in dual antiplatelet therapy; * patient with severe renal failure; * patient poor responders
self-monitoring assessment in real time

Conditions: Obesity

Summary: the purpose of the study is to test the effectiveness of two different methods of mobile dietary self-monitoring for weight loss. both of these interventions will provide weight loss information through twice weekly audio podcasts. in addition to the podcasts, participants will be asked to track their diet using an assigned mobile applications (for their smartphone), which will be randomly assigned.

this study will include an intensive phase for 6 weeks and a follow-up phase that will occur through the final 6 months of the study. participants will attend one 1-hour orientation meeting at the beginning of the study and a 2-hour baseline assessment and training meeting. a final assessment will be conducted at the end of 6 weeks with a follow-up assessment at 6 months. everyone in the study will be asked to listen to 2 podcasts per week. each of the podcasts will take about 15-20 minutes to listen to and so participants should expect to spend 30-40 minutes each week listening to podcasts. participants also will be randomized to track diet with one of the two mobile dietary tracking applications that will be used in the study. participants will be encouraged to monitor their exercise and body weight.

Eligibility criteria:
inclusion criteria: * must be between 18-65 years old * own and use a smartphone and/or a tablet with a data plan that is apple of android compatible * bmi must be between 25-49.9 kg/m2 * must be willing to reduce caloric intake and increase physical activity * not currently participating in a weight loss study or has been in a weight loss study that involved podcasts or diet apps exclusion criteria: * over the age of 65 years old * currently participating in a weight loss program * has lost more than 10 pounds in the past 6 months * diagnosed with stroke or heart attack * diagnosed with diabetes that is controlled using medication

Keywords: diet weight loss tracking mobile calories
safety/tolerability, pharmacokinetics/pharmacodynamics (pk/pd) of lcz696 in patients with stable heart failure

Conditions: Heart Failure

Summary: this study assess the safety/tolerability, pk/pd of lcz696 in patients with stable heart failure.


Eligibility criteria:
inclusion criteria: * patients with documented heart failure (nyha class ii-iv) exclusion criteria: * use of both acei and arb, acei and dri, arb and dri treatment, or all three medications at screening

Keywords: heart failure lcz696
quality of the detection & treatment of osteoporotic fractures in a swiss trauma center

Conditions: Osteoporosis, Postmenopausal; Osteoporosis

Summary: as a tertiary hospital the traumatology department at the kantonsspital aarau looks after about 500 fracture patients hospitalized with an age over 50 years a year. first, we were interested in the effective rate of osteoporotic fractures in this cohort. as to this objective we offered subsequent diagnostics in suspected patients. 2012 we introduced a diagnostic pathway for every patient over 50 years of age with a fracture, including dual energy x-ray absorptiometry (dxa), a questionnaire about risk factors concerning osteoporosis and risk of fracture, the who fracture risk assessment tool (frax) and a laboratory workup focusing on this topic. considering all these information we sent a detailed therapy-plan to the responsible general practitioner. the main goal of this study is to verify the persistence and compliance of the osteoporosis therapy 12-15 months after fracture and to clarify any obstacles potentially impeding therapy (prejudice, adverse events, contraindication overlooked, financial problems etc.). the investigators use a postal questionnaire provided to the patient and the general practitioner. data collection is undertaken by a study nurse, in addition phoning for missing data by phone-call. with the aim to ameliorate the implementation of treatment, patients and general practitioners will be provided with the specifically tailored information found to be missing.


Eligibility criteria:
inclusion criteria: * age over 50 years * any peripheral fracture, which led to hospitalisation in kantonsspital aarau, traumatology department exclusion criteria: * no informed consent * age under 50 years * not treated by traumatology department

Keywords: osteoporotic fracture treatment for osteoporosis adherence and compliance
weaning is winning? (wewin study)

Conditions: Intestinal Failure; Parenteral Nutrition

Summary: we propose a multicenter prospective study on pediatric patients with intestinal failure (if) who weaned off parenteral nutrition (pn).

children with if depend on pn. this is associated with frequent and various complications such as metabolic bone disease, micronutrient deficiencies and abnormal body composition. due to advancements in care, many patients with if are able to wean off pn; they are so called pn graduates. it is currently not well known how often complications do occur after weaning off pn, and which patients are at highest risk of developing these complications.

Eligibility criteria:
inclusion criteria: * parenteral nutrition graduates for at least 1 year, with a history of intestinal failure. * age \<18 years at time of inclusion. exclusion criteria: * no consent provided.

Keywords: quality of life pediatric
chronic insertional achilles tendonitis treated with or without flexor hallucis longus tendon transfer

Conditions: Chronic Insertional Achilles Tendonitis

Summary: the purpose of this study is to determine whether achilles tendon debridement and decompression augmented with flexor hallucis longus (fhl) tendon transfer results in improved clinical and functional outcome as measured by ankle plantar flexion strength and american orthopedic foot and ankle society (aofas) score compared to debridement and decompression alone in patients over 50 years of age with chronic insertional achilles tendinosis. h0: there will be no difference in ankle plantar flexion strength measured using a handheld dynamometer between patients randomized to achilles tendon decompression and debridement alone (group 1) and patients randomized to achilles tendon decompression and debridement augmented with fhl transfer (group 2). ha: patients randomized to achilles tendon decompression and debridement alone (group 1) will have less ankle plantar flexion strength compared to patients randomized to achilles tendon decompression and debridement augmented with fhl transfer (group 2).


Eligibility criteria:
inclusion criteria: * patients 50 years of age or older * patients diagnosed with chronic insertional achilles tendonitis * failed greater than 3 months of conservative treatment (activity and shoe modification, heel lifts, non-steroidal anti-inflammatory medications, stretching exercises, and formal physical therapy) exclusion criteria: * patients less than 50 years of age upon presentation * females of child-bearing potential * patients who have a history of ipsilateral achilles tendon rupture * history of infection in the same lower extremity * patients unable to undergo mri scan
miniject 636 in patients with open angle glaucoma uncontrolled by topical hypotensive medications

Conditions: Open Angle Glaucoma

Summary: the study will evaluate the efficacy and safety of miniject 636 and iop lowering effects with or without glaucoma medications. the procedure will be a stand-alone surgery. overall, the patient will be asked to perform several examinations up to 24 months after surgery. the primary efficacy objective of the present study is to show the iop reduction under medication 6 months after surgery compared to medicated diurnal iop at screening.


Eligibility criteria:
inclusion criteria: * diagnosis of primary or secondary open angle glaucoma during screening/baseline visit or earlier. * grade 3 (open, 20-35 degrees) or grade 4 (wide open, 35-45 degrees) according to shaffer angle grading system. * glaucoma not adequately controlled exclusion criteria: * diagnosis of glaucoma other than open angle glaucoma * grade 2, grade 1 and grade 0 according to shaffer angle grading system. * neovascular glaucoma in the study eye * prior glaucoma surgery in the study eye * clinically significant corneal disease * patients with poor vision
the simple ecg monitoring trial (comparison of a novel recording system with a standard holter monitor)

Conditions: Syncope; Pre-syncope; Atrial Fibrillation; Supraventricular Tachycardia

Summary: the purpose of this research is to simplify the standard recording system of the heart rhythm. the investigators desire to improve the ease of monitoring the cardiac rhythm for 24 hours. the investigators intent is to use a very small, innovative monitoring patch system that relieves the patient of wearing a cumbersome and uncomfortable recording system. this research trial will carry the title "the simple ecg monitoring" for comparison of a sternal ecg recording system with a standard ecg recording system for holter monitoring. the data from the investigational device is for comparative purposes only. it will not be used by medical personnel for study subject treatment or diagnostic purposes.

externally applied cardiac rhythm monitors are common tools used to diagnose symptoms that may or may not be related to cardiac rhythm abnormalities. common problems that may lead to the use of cardiac rhythm monitors are syncope (loss of consciousness), near-syncope (near loss of consciousness), palpitations (the sensation of an abnormal heart beat), or monitoring of known cardiac rhythm problems like atrial fibrillation. the purpose of this research is to confirm the clinical value of a much easier-to-use cardiac rhythm monitoring system, hereafter referred to as the investigational monitoring system. prior to discussing the investigational monitoring system, we will review standard electrocardiographic monitoring tools used to evaluate the heart's rhythm. excluding a routine 12 lead electrocardiogram that takes a snapshot view of the hearts electrical signal, the most common tool for monitoring the heart rhythm is a holter monitor. a holter monitor is also called an ambulatory cardiac monitor. a holter monitor records every heartbeat for 24 hours. it requires wearing multiple electrodes and carrying a recording system that is usually worn on a belt or on a holster strap. such systems are relatively bulky and difficult to conceal in public venues. also, their electrodes often disconnect, especially during sleep when the patient is unaware of electrode detachments that can occur when turning or during exercise. moreover, they can't be worn during showering. these shortcomings notwithstanding, standard holters remain the standard of care.

Eligibility criteria:
inclusion criteria: * syncope of uncertain etiology or * pre-syncope of uncertain etiology or * palpitations of uncertain etiology or * management of known af/svt patients exclusion criteria: * any abnormal or friable skin over the anterior thorax and upper abdomen * sternal incision within 3 months from the date of enrollment

Keywords: holter monitor, ambulatory electrocardiography monitoring
study of lenvatinib (e7080) in participants with advanced hepatocellular carcinoma (hcc)

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to determine maximum tolerated dose (mtd), efficacy, safety and tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor effect of e7080 when is administered continually once daily in participants with advanced hepatocellular carcinoma.


Eligibility criteria:
inclusion criteria: 1. histologically or clinically confirmed diagnosis of advanced hcc. 2. eastern cooperative oncology group-performance status (ecog-ps): 0-1. 3. adequate laboratory values/organ function tests. exclusion criteria: 1. simultaneous or metachronous cancers. 2. pericardial, ascites, or pleural effusion requiring drainage. 3. brain metastasis/meningeal carcinomatosis presenting clinical symptoms or requiring treatment. 4. malabsorption syndrome. 5. artery-portal vein shunt or artery-vein shunt preventing proper diagnosis of tumor. 6. use of drugs known to inhibit cytochrome p3a4.

Keywords: carcinoma hepatocellular
effectiveness of inspiratory muscle training in patient with stable angina

Conditions: Angina, Stable

Summary: stable angina is a cardiac pathology that adversely affects the quality of life of the patient, which develops as a result of narrowing of the coronary vessels developing in atherosclerotic ground and / or impaired oxygen supply-need balance. studies widely investigated the effects of exercise training in patients with stable angina. no study investigated the effects of inspiratory muscle training in patients with stable angina.investigators aimed to investigate the effects of inspiratory muscle training on aerobic exercise capacity, quality of life, depression, peripheral and respiratory (mip, mep) muscle strength, pulmonary function, dyspnea, fatigue in stable angina patients.

patients with stable angina will be included. primary outcome measurement is inspiratory muscle strength, secondary outcomes are functional exercise capacity, peripheral muscle strength, pulmonary functions, maximal exercise capacity, fatigue, quality of life, depression.

Eligibility criteria:
inclusion criteria: * no contraindication for pulmonary physiotherapy * anjina patients who are clinically stable * have no other disease that may affect respiratory function * individuals who have the good cooperation exclusion criteria: * patients under the age of 18 * pregnancy * active infection * patients with known malignancies * patients without consent * known arrhythmia, dilated or hypertrophic cardiomyopathy, heart failure (ef \<40%)

Keywords: inspiratory muscle trainig quality of life aerobic capacity depression fatique