Kornimate/medical-research-clean huggingface dataset:
video assisted ablation of pilonidal sinus versus conventional treatment

Conditions: Chronic Sacrococcygeal Pilonidal Sinus

Summary: video assisted ablation of pilonidal sinus (vaaps) is a new endoscopic minimally invasive treatment. in an attempt to validate the effectiveness of the vaaps, the investigators have designed a comparative study between the conventional and the minimally invasive treatment. two surgical procedures were evaluated: vaaps (experimental group) and conventional excision with a bascom out-midline closure (control group).


Eligibility criteria:
inclusion criteria: * chronic sacrococcygeal pilonidal sinus exclusion criteria: * absence of consent to the study * acute abscess
continuous or intermittent extension of adjuvant pyrotinib for invasive her2-positive breast cancer

Conditions: Breast Cancer Invasive

Summary: this is a prospective, randomised, controlled, multicentre study to compare the efficacy and safety between continuous or intermittent extension of adjuvant pyrotinib in invasive human epidermal growth factor receptor 2 (her2)-positive breast cancer.


Eligibility criteria:
inclusion criteria: * aged ≥18 and ≤70 years; * histologically confirmed invasive her2 positive breast cancer; * duration from random time to the last use of trastuzumab or t-dm1 ≤3 years; * performance status- eastern cooperative oncology group (ecog) 0-1; * adequate organ functions. exclusion criteria: * metastatic disease (stage iv); * gross residual disease remaining after mastectomy or positive margins after breast-conserving surgery; * subjects that are unable to swallow tablets, or dysfunction of gastrointestinal absorption; * treated or treating with anti-her2 tyrosine kinase inhibitor; * less than 4 weeks from the last clinical trial; * history of immunodeficiency, including hiv-positive, suffering from other acquired, congenital immunodeficiency disease, or history of organ transplantation; * female patients who are pregnancy, lactation or women who are of childbearing potential tested positive in baseline pregnancy test; female patients of childbearing age that are reluctant to take effective contraceptive measures throughout the trial period; * evidence of significant medical illness that in the investigator's judgment will substantially increase the risk associated with the subject's participation in and completion of the study.
clinical outcomes of angioplasty postconditioning

Conditions: Acute Myocardial Infarction

Summary: we previously demonstrated that postconditioning by coronary angioplasty can decrease infarct size (as measured by cardiac enzyme release) in patients with ongoing acute myocardial infarction. it is currently unknown whether postconditioning actually decreases or simply delays myocardial cell death during reperfusion. in addition, the long term effects of postconditioning on recovery of myocardial contraction remains elusive. the objective of the present study is to determine whether infarct size reduction by angioplasty postconditioning is maintained at 6 months and whether functional recovery is improved at one year post-infarction.

randomized, controlled, single-blinded trial comparing postconditioning to control (no intervention). postconditioning consists of four episodes of one minute inflation followed by one minute deflation of the angioplasty balloon, starting within one minute of reflow after direct stenting of the occluded coronary artery.

Eligibility criteria:
inclusion criteria: * male and female patients, aged more than 18, with suspected first acute myocardial infarction, within 6 hours of the onset of chest pain, with a need for emergency revascularization by angioplasty. patients must display a fully occluded (timi zero flow) culprit coronary artery, absence of visible collaterals and exhibit timi flow \>2 after direct stenting by angioplasty. exclusion criteria: * cardiac arrest or cardiogenic shock * occlusion of the circumflex coronary artery

Keywords: ischemia reperfusion myocardial infarction postconditioning
incidence of iatrogenic diseases on hospital's emergency consultations

Conditions: Iatrogenic Disease

Summary: french population grows older year after year: 24.3% people were over 60 years old in 2006 against 20.6% in 2000 and the expected number might be over 33% in 2050. the elderly suffer from lots of illnesses, so they usually take lots of drugs. therefore, this drug use is most likely to have adverse drug reactions. finally, according to health ministry, the number of emergency department consultations doubled from 1996 to 2016. consequently, it is interesting to study the impact of drug iatrogenic effects on emergency consultations. it would help to prevent these adverse drug reactions as we prescribe those drugs : first, do not harm.

this will be a retrospective study. the number of patients will be defined by the number of visits during a random draw of 10 emergency department consultation days between 21st june 2018 and 22nd september 2018 in toulon - la seyne sur mer public hospital. there are between 100 and 300 emergency department consultations per day in this hospital so the estimated number of patients will be between 1000 and 3000. every patient who came to hospital for a consultation in emergency department during this period of time will be included in the study except those who expressed their opposition to their data collection and treatment. each patient will be anonymized with a code defined as follows : n(ame) l(ast name) 001 (chronological inclusion number) information of the patients involved in adverse drug reactions will be extracted and a description of this patient sample will be made.

Eligibility criteria:
inclusion criteria: * man or woman over 18 years old * consultation in emergency department of sainte musse or la seyne-sur-mer hospital between 21st june 2018 and 22nd september 2018 included * consultation of the patient in emergency department during the 10 day random draw of the research (from 00h01 to 23h59) * consultation in emergency department because of a iatrogenic reason exclusion criteria: * dead patients * patient's opposition

Keywords: iatrogenic emergency incidence adverse drug reaction
reducing post-hospital mortality in hiv-infected adults in tanzania

Conditions: HIV Infections

Summary: this research is being done to assess the efficacy of a case management intervention to improve the one year mortality rate of hospitalized, hiv-infected, tanzanian adults.

this research is being done to assess the efficacy of a case management intervention to improve the one year mortality rate of hospitalized, hiv-infected, tanzanian adults. the study is being conducted at hospitals in mwanza, tanzania. 500 participants will be enrolled: 250 will be randomized to the case management intervention and 250 will randomized to routine clinical care. the case management intervention consists of 5 sessions over 90 days, and is designed to link hospitalized, hiv-infected patients to long term care at an hiv clinic. participants will be followed for two years in order to evaluate primary and secondary study objectives. secondary outcome measures time frames have been updated to add the 24-month time point for consistency with the pre-specified endpoints in the study protocol.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * hiv-infected * art (anti-retroviral therapy) naïve or have been on art but have not used art for \> 7 days * lives in the region of mwanza * able to be referred to an hiv clinic inside the region of mwanza * has mobile phone or access to mobile phone * planning to stay in the region of mwanza for the next 24 months * able to speak kiswahili or english * capable and willing to provide informed consent * willing to provide locator information and two designated contact persons * willing to have a home visits from a study team member exclusion criteria * pregnant * on anti-retrovirals at hospital admission and already linked to an hiv clinic * medical, psychiatric or psychological condition that, in the opinion of the site investigator, would interfere with completion of study procedures
dmhi for at-risk college students

Conditions: Prodromal Symptoms; Psychosis

Summary: the goal of this clinical trial is to learn if a single-session digital intervention (spark coping) is acceptable, usable, and demonstrates a preliminary signal of efficacy in reducing symptom-related distress and increasing positive treatment-seeking attitudes among college students reporting subthreshold symptoms associated with risk for psychosis. research questions inclue: * does spark coping reduce symptom-related distress and increase positive treatment seeking attitudes (primary outcomes) relative to a waitlist control condition? * does spark coping increase adaptive coping and reduce internalized stigma (primary targets) relative to a waitlist control condition? researchers will compare provision of spark coping to a waitlist control condition and collect data from participants on each of the variables described above. participants will: * complete questionnaires and surveys remotely at the start of the study and two weeks later * be offered access to the spark coping intervention either after completion of their baseline assessment (intervention arm) or after two weeks (waitlist control arm).


Eligibility criteria:
inclusion criteria: * symptoms indicating risk for psychosis (a distress score \>= 20 on the prodromal questionnaire, brief \[pq-b\], per savill et al., 2018; early intervention in psychiatry and a positive frequency average score \>= 1.47 on the community assessment of psychic experiences (cape-p15), per jaya et al., 2021 and bukenaite et al., 2017) * residence in the united states * currently enrolled in a post-secondary college program. exclusion criteria: * inconsistent or implausible reporting of symptoms at screening as determined by empirically-determined methods for detecting malingering or inconsistency * failure to demonstrate understanding of study details in comprehension screening

Keywords: college student mental health
liver resection for patients with hepatocellular carcinoma and clinically significant portal hypertension

Conditions: Hepatic Carcinoma

Summary: clinically significant portal hypertension limits the therapeutic options for hepatocellular carcinoma (hcc), which is closely associated with patient prognosis. hcc patients with cpsh are heterogeneous and treatment allocation remains controversial. the aim of this study was to compare the survival benefits of liver resection (lr) and transarterial chemoembolisation (tace) in these populations.


Eligibility criteria:
inclusion criteria: * hcc patients treated conventional liver resection or transarterial chemoembolisation exclusion criteria: * (1) presence of types iii/iv portal vein tumour thrombosis (pvtt), hepatic artery, biliary duct or inferior vena cava invasion; (2) presence of extrahepatic spread (ehs); (3) underwent previous treatments; (4) eastern cooperative oncology group performance status (ecog-ps) \>1; (5) diffuse tumor nodules; (6) combined with other tumours or severe cardiac, cerebral, and renal insufficiency; (7) non-clinically significant portal hypertension（csph）, and (8) absence of baseline information
effects of internet - based cognitive behavioral therapy on sleep problems among sample of post- menopausal

Conditions: Sleep Problem

Summary: sleep problems become more prominent with aging and worse among post-menopause than perimenopause stage. the actual causes of sleep problems are unclear. however, it occurs commonly accompanied with or in the response of seriousness of menpausal symptoms as nocturnal hot flashes, mood disorders, and obstructive sleep apnea among menopauses. the prevalence of sleep problems is variable ranged from 11.8 -62 % based on different studies. cognitive-behavioral therapy (cbt) is one of the short-term form of psychotherapy, used for managing sleep problems and insomnia , an efficacious as pharmacological treatment.

as life expectancy has increased, women spend more than one-third of their lives in menopausal transition (mt) and the subsequent post menopause (pm).as a result of hormonal changes women experiences such symptoms as hot flashes, mood swings, anxiety, and sexual dysfunction that deteriorate their quality of life. those symptoms usually begin in 45-53-year-olds and it varies in onset and severity from women to another and from country to another. symptoms of sleep problems include the difficulty of falling asleep, fractioned sleep, night-time awakening, the inability of resuming sleep, problems in waking up, fatigue, and daytime sleepiness that potentiate poor physical and mental quality of life. the goal of cbt is to teach women how to modify maladaptive behaviors and thoughts that may contribute to a particular problem as sleep problems, anxious thoughts, and vasomotor symptoms

Eligibility criteria:
inclusion criteria: 1. menopaused women age between 50 and65 years 2. able to read and write 3. being normally ( primary ) menopause at least one year 4. willing to give written informed consent to participate in the study. 5. women obtaining more than 5 of the total score of the pittsburgh sleep quality index (psqi)( that indicates poor sleep ) 6. have smartphone with internet access (whatsapp) application exclusion criteria: 1. has serious physical disorders or uncontrolled conditions as uncontrolled blood pressure , uncontrolled blood glucose level, on hemodialysis 2. receiving psychotropic medications, hormone replacement therapy (hrt), 3. undergoing hysterectomy 4. has acute or chronic surgical conditions, cancer or any other serious illness 5. has cognitive impairments or physical handicap 6. giving prescribed or non-prescribed medication or herbals that influencing sleep .

Keywords: post menopausal intervention sleep problems cbt
observational study of hiv infected women previously enrolled in other microbicide trials

Conditions: HIV Infections

Summary: a new approach to hiv prevention currently being studied includes the use of topical microbicides and orally administered anti-hiv drugs. the purpose of this study is to better understand the impact of microbicides in women who are diagnosed with hiv-1 during participation in previous microbicide trials.

it is necessary to monitor hiv over long periods of time in order to better understand the impact of microbicides and anti-hiv drugs on the progression of hiv infection in those who become infected or are unknowingly already infected while receiving these drugs. the purpose of this study is to determine the effects of microbicides or oral anti-hiv drugs over time in hiv infected women who were previously enrolled in other microbicide trials. the study will remain open to accrual for the duration of mtn funding, and will use two follow-up visit schedules, one based on the date of diagnosis in the parent study, and one based on the initiation of antiretroviral treatment (art). participants who have not initiated art at the time of enrollment in this study will follow the schedule based on the date of diagnosis. participants who have already begun art at the time of enrollment will follow the schedule based on the date of art initiation. individuals enrolled with a starting date based on the date of art initiation will have their first follow-up visit at week 2 before resuming the rest of the schedule. on both schedules, follow-up visits occur at months 1, 3, and 6 and every 6 months thereafter. interim visits may be performed at any time during follow-up, and participants will be asked to attend a final study visit prior to their termination from the study. participants may enroll any time after their hiv diagnosis and can leave the study at any time. a physical exam; medical and medication history assessment; blood and urine collection; and pelvic, cervicovaginal lavage, and vaginal swab sampling will occur at all visits. a behavioral assessment will occur at select visits, and adherence and social harms assessments will occur at most visits. sexually transmitted infection risk reduction/contraception and hiv-1 secondary counseling will occur at most visits. in addition, condoms will be provided at all visits to reduce further hiv transmission. art will not be provided by this study.

Eligibility criteria:
inclusion criteria: * diagnosis of hiv-1 infection during participation in any microbicide trials network (mtn) clinical trial (including hptn 035 and hptn 059), according to the hiv testing algorithm of the parent mtn trial * parent or guardian willing to provide informed consent, if applicable exclusion criteria: * any condition that, in the opinion of the investigator, makes participation in the study unsafe or interferes with the study

Keywords: microbicide seroconversion treatment experienced treatment naive
a trial of group psychotherapy for veterans and military personnel with post traumatic stress disorder (ptsd)

Conditions: Posttraumatic Stress Disorder; Depression; Insomnia Disorder

Summary: the purpose of this study is to test the effectiveness of group psychotherapy designed specifically for male veterans and active-duty personnel with post-traumatic stress disorder (ptsd), major depressive disorder (mdd) and with disturbances in their sleep or daily routine.

the purpose of this study is to test the effectiveness of a group psychotherapy designed specifically for male veterans and active-duty personnel with post-traumatic stress disorder (ptsd), major depressive disorder (mdd) and with disturbances in their sleep or daily routine. we will compare two group therapies, one of which has been examined in previous studies for veterans with ptsd. both group therapies have been shown to reduce symptoms of anxiety and depression in some veterans. however, neither group therapy has been proven to be more effective than treatment as usual for ptsd.

Eligibility criteria:
inclusion criteria: * veteran or active duty military personnel * current posttraumatic stress disorder (ptsd), at least moderate severity * criterion a exposure to trauma occurring after the age of 18 * major depressive disorder (mdd), at least moderate severity * disturbances in sleep (primary insomnia, insomnia related to ptsd, or nightmare disorder) or daily routine exclusion criteria: * current or past bipolar disorder * current psychotic disorder * substance abuse/dependence in last 30 days * uncontrolled serious medical condition or neurological disorder * currently working an overnight shift * primary untreated sleep apnea, restless legs syndrome

Keywords: posttraumatic stress disorder depression sleep initiation and maintenance disorders insomnia psychotherapy, group cognitive behavioral therapy randomized controlled trial veterans social rhythms
study of gemcitabine, abraxane® plus placebo versus gemcitabine, abraxane® plus 1 or 2 truncated courses of demcizumab in subjects with 1st-line metastatic pancreatic ductal adenocarcinoma

Conditions: Pancreatic Cancer

Summary: this is a randomized, double blind, 3 arm (1:1:1) study in subjects with 1st-line metastatic pancreatic ductal adenocarcinoma. the purpose is to test the efficacy and safety of demcizumab, when given in combination with gemcitabine and abraxane® compared to placebo. the administration of gemcitabine and abraxane® is a standard treatment for patients with metastatic pancreatic ductal adenocarcinoma.


Eligibility criteria:
inclusion criteria: 1. subjects must have histologically confirmed metastatic pancreatic ductal adenocarcinoma.. prior chemotherapy and/or radiotherapy either in the adjuvant or neoadjuvant setting or for metastatic disease is not allowed. 2. availability of formalin-fixed paraffin-embedded (ffpe) tumor tissue (from either the primary tumor, locoregional disease or a metastatic site), either fresh core-needle-biopsied or archived (two ffpe cores preferred whenever possible). if fresh tissue is obtained, the core biopsy must be done at least 7 days prior to randomization. 3. age ≥21 years 4. eastern cooperative oncology group (ecog) performance status 0 or 1 5. measurable disease per recist v1.1 5. adequate organ and marrow function 6. signed informed consent form 7. for women of childbearing potential, agreement to use two effective forms of contraception exclusion criteria: 1. subjects with a neuroendocrine tumor of the pancreas, an acinar tumor of the pancreas or a pancreatic tumor with mixed histologies. 2. subjects receiving heparin, warfarin, factor xa inhibitors or other similar anticoagulants. note: subjects may be receiving low-dose aspirin and/or non-steroidal anti-inflammatory agents. 3. subjects with brain metastases, leptomeningeal disease, uncontrolled seizure disorder, or active neurologic disease 4. subjects with grade \>2 peripheral neuropathy 5. subjects with clinically significant ascites 6. malignancies other than pancreatic cancer successfully treated within 3 years prior to randomization, except for adequately treated carcinoma in situ of the cervix, basal or squamous cell skin cancer, treated superficial bladder cancer, localized prostate cancer treated surgically with curative intent, ductal carcinoma in situ treated surgically with curative intent 7. significant intercurrent illness that will limit the patient's ability to participate in the study or may result in their death over the next 18 months 8. history of a significant allergic reaction attributed to humanized or human monoclonal antibody therapy 9. subjects with known clinically significant gastrointestinal disease including, but not limited to, inflammatory bowel disease 10. pregnant women or nursing women 11. subjects with known hiv infection 12. known bleeding disorder or coagulopathy

Keywords: 1st-line metastatic pancreatic ductal adenocarcinoma
the relationship between ergonomic knowledge of healthcare professionals and musculoskeletal disorders

Conditions: Occupational Diseases

Summary: this study aims to investigate the relationship between the ergonomic awareness levels of healthcare workers and musculoskeletal disorders.

the present study is planned to be online. personal information such as age, gender, and occupation will be collected from participants. ergonomics information will be questioned. the nordic musculoskeletal disorders questionnaire will be applied for the musculoskeletal disorders of the participants. occupational burnout caused by musculoskeletal disorders will be investigated with the maslach burnout scale. the degree to which musculoskeletal disorders affect sleep quality will be investigated with the pittsburgh sleep quality questionnaire.

Eligibility criteria:
inclusion criteria: * being between 25 and 45 years old. * being a health worker * having at least 2 years of work experience exclusion criteria: * participant having a musculoskeletal disorder before the study * having had surgery within 6 months * being pregnant * having a traumatic accident or injury that would affect the study