Kornimate/medical-research-clean huggingface dataset:
liposomal bupivacaine for post operative pain after knee replacement surgery

Conditions: Post-operative Pain

Summary: continuous femoral nerve blocks (cfnb) provide effective pain control to patients undergoing total knee replacement (tkr). however the resulting motor blockade can lead to decreased quadriceps muscle strength and delayed functional recovery.the purpose of this study is to compare the effect of liposome bupivacaine infiltration into the knee to cfnb on pain control and functional recovery

this is a prospective, randomized, active controlled study in patients undergoing total knee replacement. the objective of this study is to compare the efficacy of liposome bupivacaine, in managing postoperative pain, to standard of care cfnb. following informed consent, patients will be randomized to one of two groups, liposome bupivacaine or active control, cfnb group. 266 mg liposome bupivacaine plus bupivicaine hcl (150mg) will be administered via local joint infiltration around the knee joint prior to wound closure. in the control group a cfnb will be placed for 48hrs prior to surgery. outcomes measured included pain at rest, movement and quadriceps muscle strength on the first and second postoperative day. it is hypothesized that liposome bupivacaine will provide effective pain control and improved preservation of quadriceps muscle strength, in comparison to cfnb.

Eligibility criteria:
inclusion criteria: * asa status i-iii * scheduled to undergo primary unilateral total knee arthroplasty exclusion criteria: * patients who are pregnant or nursing * alcohol or narcotic dependence within the last 2 years * condition requiring regular use of analgesia that may confound post surgical assessments as determined by principle investigator * bmi \> 40kg/m2 * contraindication to acetaminophen, morphine, oxycodone, ketorolac, epinephrine, or pathological conditions potentially aggravated by epinephrine * allergies to amide-type local anesthetics * any disease condition or lab result that could complicate a patients postoperative recovery * history of hypotension * abnormal liver, renal or cardiac function * other physical, mental or medical conditions that, in the opinion of the investigator, make study participation inadvisable.
ketamine versus dexmedetomidine with local anesthetic in tap block

Conditions: Postoperative Analgesia; Lower Abdominal Cancer

Summary: comparing the analgesic effects of ketamine and dexmedetomidine when added to local anesthetic in tap block for postoperative analgesia after lower abdominal cancer surgery.


Eligibility criteria:
inclusion criteria: * all patients asa i and ii to whom abdominal surgery for cancer will be conducted will be included in the study exclusion criteria: * coagulopathies * asa iii or iv, patient refusal, sensitivity to the used drugs
virtual reality guided acupuncture imagery treatment for chronic low back pain

Conditions: Chronic Low-back Pain

Summary: testing the effect of virtual reality - guided imagery acupuncture

the aim of this study is to develop a virtual reality guided acupuncture imagery treatment system for the treatment of chronic low back pain. this product will provide a new cost-effective treatment option for chronic low back pain and potentially other chronic pain disorders.

Eligibility criteria:
inclusion criteria: * volunteers 18-75 years of age. * meet the classification criteria of chronic lbp (having low back pain for more than 6 months), as determined by the referring physician. * at least 4/10 clinical pain on the 11-point lbp intensity scale. * must have had a prior evaluation of their low back pain by a health care provider, which may have included radiographic studies. documentation of this evaluation will be sought from partners or outside medical records and kept in the subject's research record. * at least a 10th grade english-reading level; english can be a second language provided that the patients feel they understand all the questions used in the assessment measures. exclusion criteria: * specific causes of back pain (e.g. cancer, fractures, infections), * complicated back problems (e.g. prior back surgery, medico legal issues), * possible contraindications for acupuncture (e.g. coagulation disorders, cardiac pacemakers, pregnancy, seizure disorder), and conditions that might confound longitudinal effects or interpretation of results (e.g. severe fibromyalgia, rheumatoid arthritis). * conditions making study participation difficult (eg, paralysis, psychoses, or other severe psychological problems as per the judgment of a study investigator during session 1) * the intent to undergo surgery during the time of involvement in the study. * unresolved medical legal/disability/workers compensation claims in connection with low back pain. * lacking the capacity to consent for oneself * do not have access to zoom or other software regularly to complete the study.
breast implant-associated anaplastic large cell lymphoma (bia-alcl) registry

Conditions: Anaplastic Large Cell Lymphoma Associated With Breast Implants (BIA-ALCL)

Summary: anaplastic large cell lymphoma associated with breast implants (bia-alcl) is a rare disease seen only in women with a breast implant. because of the low incidence of this disease and the peculiar histological subtype, french authorities, in accordance with the recommendations of an expert group, recommended the implementation of a bia-alcl case registry, in connection with a national multidisciplinary meeting (réunion de concertation pluridisciplinaire nationale de recours- rcp). this registry is opened in france and in belgium


Eligibility criteria:
inclusion criteria: * adult patients with an anaplastic large cell lymphoma associated with breast implants exclusion criteria: -

Keywords: bia-alcl
investigation of the acute effects of percussive massage treatment and stretching exercise on balance and performance

Conditions: Sports Physical Therapy

Summary: in this study, it was aimed to investigate the acute effects of percussion massage therapy and stretching exercises on balance, horizontal jumping and performance in healthy individuals. it was planned to include 45 individuals in the study. participants will be randomly divided into 3 groups. horizontal jumping distance, t-drill test and balance assessment will be done for all participants. after the evaluation, percussion massage therapy will be given to the 1st group, dynamic stretching exercises to the 2nd group, and static stretching exercises to the 3rd group. all measurements will be repeated after the intervention.

48 healthy individuals meeting the inclusion criteria of istanbul medipol university will be included in the study. individuals who are at a level to perform performance tests, who have not undergone orthopedic surgery in any of their regions, who do not have problems in running and during sudden turns, and who do not have a professional sports background will be included in the study. individuals with a history of trauma, anatomical deformities and skeletal system fractures, diagnosed orthopedic or rheumatological diseases, being included in the physiotherapy program in the last 6 months, and those with pain in any region will be excluded from the study. before the study, demographic information, horizontal jump test, t-test and fizyosoft balance system will be evaluated with both feet and one foot with eyes open and closed. after the evaluation, percussion massage therapy will be given to the 1st group, dynamic stretching exercises to the 2nd group, and static stretching exercises to the 3rd group. all measurements will be repeated after the intervention.

Eligibility criteria:
inclusion criteria: * capable of performing performance tests * those who have not undergone orthopedic surgery in any region * having no problems during running and sudden turns * individuals who do not have a professional sports background exclusion criteria: * trauma history * anatomical deformities and skeletal system fractures * diagnosed orthopedic or rheumatological diseases * being included in a physiotherapy program in the last 6 months * individuals with pain in any part of the study

Keywords: percussion massage therapy dynamic stretching static stretching
your health in on click

Conditions: College Student Drinking; Eating Disorder; Stress, Psychological; Burn Out Syndrome; Cigarette Smoking; Hyperactivity; Health Behavior; Impulsive Behavior

Summary: a health education program was provided to higher education students aged between 18 and 25 years. students were recruited either by posters and leaflets on campus, or during their mandatory medical survey at the university medical department. the objectives are to assess health behavior risk among college student : e.g eating disorders, binge drinking, electronic cigarettes and also stress, burnout


Eligibility criteria:
inclusion criteria: * aged 18-25 years * college students exclusion criteria: * no college students
studies of kidney transplant outcome

Conditions: Transplant Recipient (Kidney); Steroid-Free Maintenance Immunosuppression; Post-Transplant Infections; Thymoglobulin

Summary: the purpose of this study is to improve outcome for kidney transplant recipients. there has not been commensurate improvement in medium and long-term outcomes. ongoing clinical research is necessary to improve transplant outcomes.

this study is looking at information already collected of transplant outcomes (short, medium and long-term complications and quality of life). this will specifically look at: 1. 10 year follow-up of steroid-free maintenance immunosuppression 2. a cross-sectional study of infection after kidney transplantation (with emphasis on infection in steroid-free recipients 3. an evaluation of the delayed graft function (dgf) nomogram in thymoglobulin treated recipients at the university of minnesota

Eligibility criteria:
inclusion criteria: * kidney transplant recipient at the university of minnesota * kidney transplant recipients on steroid-free maintenance immunosuppression exclusion criteria: * non-kidney transplant patients at the university of minnesota

Keywords: thymoglobulin kidney transplant recipients steroid-free immunosuppression
assessment of maximal incisal opening using patient specific titanium eminoplasty versus inlay autogenous bone graft for treatment of chronic mandibular condylar dislocation

Conditions: Chronic Mandibular Condylar Dislocation

Summary: in the small and highly specialized field of tmj surgical treatments, restriction of the mandibular condylar movement outside of the articular eminence is one of the treatment choices suggested in tmj dislocation. limitation of translation of the condyle in tmj dislocation by inlay autogenous bone graft is the classic method to hinder the movement of the condyle beyond the articular eminence. patient specific tmj prosthesis is very promising nowadays that it will not only build on the strengths of the current tmj systems but will take advantage of digital innovations in custom design and three-dimensional(3d) printing of tmj prosthesis. moreover, tmj titanium eminoloplasty was reported to be a predictable and flexible instrument for tmj dislocation treatment. thus, the investigators are conducting this study to compare the effect of both methods on the improvement of the maximal incisal opening of patients with chronic mandibular condylar dislocation, aiming to solve the problem of increasing the mouth opening of patients in their daily mouth opening. also to reduce the community's fear from such a problem, which sometimes prevent patients from seeking treatment at their dentists leading to more serious complications that can be avoided. furthermore, the investigators are trying to provide an evidence for oral and maxillofacial surgeons in order to provide the best quality service with the least expenses and thus gaining the patients' trust and saving time, money and effort.


Eligibility criteria:
inclusion criteria: * medically free patients. * long-standing dislocation of the tmj for more than 3 weeks and the failure of manual reduction. * failure of conservative strategies such as orientation to self-limit jaw movement and the use of a chin-cap or bandage. * previous failed tmj surgery. * age range is between 18 and 40 years with no sex predilection. * patients who can understand visual analogue scales (vas) and are able to sign informed consent * highly motivated patients exclusion criteria: * pregnant females. * patients having a significant systemic disorder. * psychological disorders, drug or alcohol dependency. * known allergies or sensitivities to dental materials, including titanium or general anasethic agents. * severe medical conditions that would not allow management in the clinic. * inability to return for follow up visits.
comparison of care practices, mortality and morbidity of very preterm infants between two tertiary centers in northwest and south of china

Conditions: Morality; Morbidity;Newborn; Very Preterm Maturity of Infant

Summary: care practices, mortality and morbidity of very premature infants from two different tertiary centers were collected and compared, in order to discover areas for improvement where these two newborn centers can learn from each other.

this retrospective cohort study was conducted in two hospitals,qinghai red cross hospital and jinan university affiliated shenzhen baoan women's and children's hospital.very premature infants born with a gestational age between 22+0 - 31+6 weeks admitted to both centers during 3 years from january 1, 2018 to december 31, 2020 were studied. in both centers, data including maternal characteristics, neonatal characteristics, obstetric practices, delivery room practices, and neonatal outcomes, were collected by data abstractors in each nicu. anonymous data was transferred to shenzhen and analyses were performed at the newborn center of szh.

Eligibility criteria:
inclusion criteria: * very premature infants born with a gestational age between 22+0 - 31+6 weeks； * admitted to both centers during 3 years from january 1, 2018 to december 31, 2020. exclusion criteria: * infants not born at qhh or szh (out born); * infants who had major congenital anomalies; * infants admitted after 7 days of life.

Keywords: care practices mortality morbidity very preterm infant comparison
intrauterine flushing with follicular fluid plus granulosa cells

Conditions: Follicular Fluid; Granulosa Cell; Embryo Implantation

Summary: one hundred forty patients with male factor infertility are randomized into two groups. in the study group, flushing the endometrial cavity with 2ml of clear follicular fluid with granulose cells will be performed using an iui catheter after ovum pick-up while in the control group, no flushing of the endometrial cavity with ff is done. the implantation rates and pregnancy rates in both groups will be assessed.

this study is a randomized clinical trial to investigate implantation rate and clinical pregnancy after intrauterine flushing of infertile patients with follicular fluid plus granulosa cells - randomized controlled trials. the study protocol is approved by the ethics committee (institutional review board) of royan institute and all participants provide informed consent. the main objective of this study is evaluation of implantation rate and clinical pregnancy after flushing of uterine in infertile patients with follicular fluid plus granulosa cells in ivf/ icsi cycles. material and methods: in a randomized clinical trial, 140 patients with male factor infertility referring to infertility clinic of royan institute, iran, who received ovarian stimulation with antagonist and agonist protocol, will be randomly assigned to two groups: in case group, if the follicular fluid of two clear dominant follicles contain at least 2 coc, after removal of the cocs, follicular fluid will be collected endometrial cavity flushing with 2 ml of follicular fluid will be performed by iui caterer. in control group only catheterization of uterine cavity will be performed. primary outcome is comparison of implantation rate between case and control group. secondly outcome is assessment of clinical pregnancy rate in both groups.

Eligibility criteria:
inclusion criteria: 1. normal hormonal profile (fsh, lh, amh) and normal afc 2. normal ovarian reserve 3. age 20-38 years 4. regular menstrual cycle 5. ivf / icsi or ivf or icsi cycles with agonist and antagonist protocol 6. existence of at least 2 oocytes in dominant follicular fluids exclusion criteria: 1. presence of endometriosis and endometrioma 2. hydrosalpinx 3. ohss (ovarian hyper stimulating syndrome) 4. tubal factor infertility 5. male factor infertility with azoospermia 6. low/poor response 7. myoma with a compression effect or submocusa myometrium 8. intra mural or subserouse myoma \> 5cm 9. presence of untreated thyroid, diabetic and hepatitis diseases, vaginal infection. 10. endometrial tuberculosis 11. the follicular fluid which contains any oocyte or contaminated with blood will be discarded
a study to evaluate the effect of iv doses of rivipansel in subjects with moderate hepatic impairment and in healthy subjects with normal hepatic function

Conditions: Moderate Hepatic Impairment; Normal Hepatic Function

Summary: the purpose of this study is to determine the effect of hepatic impairment on rivipansel pk and safety.


Eligibility criteria:
inclusion criteria: * female subjects of non-childbearing potential or male subjects * body mass index (bmi) of 17.5 to 40.0 kg/m2 * normal hepatic function for the healthy subjects * stable hepatic impairment for the subjects with moderate hepatic impairment exclusion criteria: * treatment with an investigational drug within 30 days of the dose of study medication * pregnant females, breastfeeding female subjects and male subjects with partners currently pregnant * use of herbal supplements in the 28 days prior to the dose of study medication * blood donation (excluding plasma donation) of approximately 1 pint or more within 56 days prior to study medication * a positive urine drug screen for illicit drugs

Keywords: hepatic impairment rivipansel
comparison of the performance of an optimized 3d epi swi sequence and a non-epi qsm swi sequence in detecting the central vein sign in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: patients who have agreed to participate in the study will complete the mri protocol as part of routine care, to which four additional 20-minute sequences will be added. mri of routine care in the context of ms includes at least the following sequences: * 3d t1 tfe (2 minutes) * t2 tse (2 minutes) * 3d flair (3 minutes) * swi epi 0.6 iso (7 minutes) the sequences added by the search are: * swi non epi qsm 6 echo (10 minutes) * swi epi in resolution equivalent to non-epi swi (3 minutes) * swi epi to tr equivalent to swi non epi (6 minutes) these sequences will be acquired before or after the injection of gadolinium (if present in the examination of routine care). for examinations carried out with injection, the order of carrying out the 4 post-injection swi sequences will be random.


Eligibility criteria:
inclusion criteria: * patients over 18 * with ms defined according to the mcdonald's revised clinical or radiological spatial and temporal dissemination criteria, with onset of symptoms \<5 years * to benefit as part of care from an mri with or without injection of gadolinium * express consent to participate in the study * affiliate or beneficiary of a social security scheme exclusion criteria: * patient benefiting from a legal protection measure * pregnant or breastfeeding woman
comparative pharmacokinetics of afolia and gonal-f® after single subcutaneous application

Conditions: Healthy

Summary: comparative pharmacokinetics study after single subcutaneous application of afolia and the reference product (gonal-f®). objective: to demonstrate equivalence within the 80%-125% margin of the reference product for the area under the curve (auc) of afolia compared to (gonal-f®).


Eligibility criteria:
inclusion criteria: * healthy female volunteers * age between 18-38 years * body mass index 17-29 kg/m2 * woman of child bearing potential must agree to practice effective barrier methods for birth control * use of oral contraceptives for at least 3 months before study entry * regular menstruation cycle (25-34 days) before initiation of oral contraception * presence of both ovaries * normal findings in medical history and physical and gynaecological examination unless the investigator considers an abnormality to be clinically irrelevant for this study * signed informed consent exclusion criteria: * polycystic ovary syndrome (pcos) * history of hypersensitivity to fsh (ovary hyperstimulation syndrome, ohss) * impaired thyroid function (treated or untreated) * history of malignant disease * ast and/or alat \> 2 x uln * other clinically relevant findings (ecg, blood pressure, physical, gynecological examination, laboratory examination) * smoking habits of more than 5 cigarettes per day * abuse of alcoholic beverages and drugs * participation in a clinical trial within 3 weeks prior to the study * foreseen inability to attend to scheduled study visits * symptoms of a clinically relevant illness during 3 weeks prior the first study day * pregnancy or lactation period * any medical condition that, in the opinion of the investigator, would interfere with safety of the subject or interference of the objectives of the study

Keywords: recombinant human follicle stimulating hormone pharmacokinetics bioequivalence
combined effects of manual therapy on the shoulder

Conditions: Range of Motion; Manual Therapies; Shoulder Joint Disorder

Summary: interventions including glenohumeral mobilization, sleeper stretches, and thoracic manipulation have been proposed for individuals with loss of shoulder range of motion (rom). however, the effect of these interventions on shoulder rom, joint translation, and muscular activity have not been studied in combination.

forty individuals with a loss of internal rotation (ir) rom will be recruited and randomized to one of two interventions at the first session: either posterior glenohumeral mobilization or internal rotation "sleeper" stretching. at the second visit, all participants will undergo a thoracic manipulation (t3-4 segment) followed by a repeat of either the sleeper stretch or glenohumeral mobilization.

Eligibility criteria:
inclusion criteria: * loss of ir of 15 degrees of greater compared to contralateral shoulder exclusion criteria: * currently neck/upper back pain, * history of spinal fractures, * numbness/altered sensation of the arms or legs, * whiplash injury within the prior 6 weeks, * infections of the spine, * currently pregnant/possibly pregnant, * known osteoporosis, * rheumatoid arthritis, * previous spine surgery, * currently receiving workman's compensation, * any pending litigation regarding a neck or shoulder injury, * history of oral corticosteroids in the prior 6 months, * history of shoulder fractures, * current treatment for cancer, * prior history of cancer involving the spine/shoulder, * any history of coagulation disorders. * individuals with a history of shoulder surgery will reviewed on a case by case basis.

Keywords: shoulder glenohumeral internal rotation deficit (gird) joint play muscular activity