Kornimate/medical-research-clean huggingface dataset:
development and feasibility analysis of verbal expressive skills management programme (vesmp) for patients with broca aphasia

Conditions: Aphasia, Broca; Stroke

Summary: the present study was conducted to develop the verbal expressive skills management programme (vesmp) to enhance verbal expressive skills of patients with severe broca aphasia. to determine the efficacy of vesmp in improving the quality of life and level of satisfaction of aphasic stroke patients.control group received traditional therapy and experimental group received therapy through vesmp programme on their smart phones.

speech therapy makes an integral part of the non-pharmacological, conservative management of post stroke aphasia. routine speech therapy aims to improve comprehension and verbal skills and also develop functional communication skills through augmentative alternative communication devices. disorders of communication, including aphasia (mainly post stroke) caused by the left hemisphere brain damage, is a major community health issue. aphasia is a language disorder occurring mainly as a result of stroke. it is an acquired impairment of language that weakens people's ability of comprehension and expression, it does not show any affect to intellect ability. the verbal expressive skills management programme (vesmp) is the software which developed augmented management for patients to enhance verbal expressive skills for patients with severe broca's aphasia from different geographic areas.

Eligibility criteria:
inclusion criteria: * the 40-60 year broca aphasia patients * the severe broca aphasia patients (more than 03 month of onset of stroke) both infarct and hemorrhagic stroke * either gender informed consent exclusion criteria: * • broca aphasic patients having cognitive impairment * the patients having tumors, infections and trauma

Keywords: stroke aphasia broca aphasia communication skills verbal expressive skill management programme
comparison between rtx (biphasic cuirass ventilator) and physiotherapy in cystic fibrosis patients

Conditions: Cystic Fibrosis

Summary: the purpose of this study is to compare the effectiveness of different mucous clearance techniques in cystic fibrosis patients

cystic fibrosis (cf) is associated with chronic progressive lung disease that may lead to respiratory failure.bi-phasic cuirass ventilation (bpcv) is a form of non-invasive respiratory support, which can provide negative pressure ventilation as well as high frequency chest wall oscillations and cough mode.the standard therapy for cf patients to release mucous is treatment by a physiotherapist. in this study we will compare the effect of bpcv with regular physiotherapy by full pulmonary function testing prior and post treatment.

Eligibility criteria:
inclusion criteria: * cf patients over 7 years old exclusion criteria: * hemoptysis * pregnancy

Keywords: cystic fibrosis physiotherapy pulmonary function test
improving the health of parents and their adolescent and transition-age youth with intellectual and developmental disabilities

Conditions: Intellectual Disability

Summary: this study will determine the comparative effectiveness of go act, a tailored advocacy curriculum versus peer parent-directed peer learning for increasing parent activation for parents of youth with intellectual and developmental disabilities. second, it will determine the comparative effectiveness of the two study arms for improving parent and youth health outcomes while assessing whether parent activation serves as a mechanism that mediates their effects on health outcomes.

a well-functioning system of care should provide a broad array of services that can support families with a child with complex health care needs. nonetheless, adolescents and transition age youth with intellectual and developmental disabilities experience rates of unmet need for health care up to 6 times higher than others resulting in poor health and quality of life for themselves and their families. the system of care approach has achieved positive impacts for children with intellectual and developmental disabilities and their families, but updates call for training to help parents develop advocacy skills on behalf of their children. prior research on diverse populations indicates that parent advocacy skills are a promising target for increasing parent self-efficacy, which in turn is associated with better parent and youth health outcomes. parent advocacy skills can be increased through a psycho-educational advocacy skills curriculum or through parent-directed peer-learning. however, the comparative effectiveness of these two strategies for families raising youth with intellectual and developmental disabilities is not yet known. this study has two objectives. first, it will determine the comparative effectiveness of go act, a tailored advocacy curriculum versus peer parent-directed peer learning for increasing parent activation for parents of youth with intellectual and developmental disabilities . second, it will determine the comparative effectiveness of the two study arms for improving parent and youth health outcomes while assessing whether parent activation serves as a mechanism that mediates their effects on health outcomes.

Eligibility criteria:
inclusion criteria: parents * bringing their adolescent or young adult child (age 11-27), with diagnosed or suspected intellectual or developmental disability, to one of the participating clinics * able to attend group sessions * able to give informed consent * resident of north carolina youth * being between the ages of 11 and 27 * having diagnosed or suspected intellectual or developmental disability * being present for a visit at one of the study clinics exclusion criteria: parents * having evidence of emergency mental health needs * not willing to be recorded
intervention to promote changes of healthy lifestyle (physical activity and nutrition) during gestation

Conditions: Excessive Weight Gain During Pregnancy; Gestational Diabetes

Summary: the purpose of this study are: * assess the impact of an intervention to the adoption of healthy lifestyles among pregnant women at high risk of gestational diabetes mellitus on: * weight gain in pregnancy * the levels of maternal and fetal adipokines and * glycemic control maternal and fetal. * determine whether the adoption of healthy lifestyles in pregnancy is associated with epigenetic changes that influence the levels of adipokines and glucose regulation during pregnancy and in newborns.


Eligibility criteria:
inclusion criteria: * be aged ≥ 18 years, * have a pre-pregnancy bmi ≥ 25 kg/m2, * be at risk of developing a gestational diabetes mellitus (a history of gestational diabetes mellitus or glucose 1 hour post-50g \> 7.1 mmol/l. exclusion criteria: * pre-pregnancy diabetes detected in the first trimester (a1c \> 6.5%, fasting glucose \> 7.0 mmol/l, random blood glucose\> 11.1 mmol/l, glucose \> 10.3 mmol/l 1 hour post-50g) * twin pregnancy * taking medications that can affect blood sugar or weight, * practice ≥ 150 minutes of physical activity per week * against formal-indication for physical activity.

Keywords: weight gain healthy lifestyle gestational diabetes adipokins glycemic regulation
evaluation of hemotypesc as a novel rapid test for point-of-care screening for sickle-cell disease, hemoglobin c disease, and carrier status in low-resource settings

Conditions: Diagnoses Disease

Summary: sickle cell disease is a life-threatening genetic disorder that can be effectively treated following early diagnosis via newborn screening. however, sickle cell disease is most prevalent in low-resource regions of the world, where newborn screening is rare due to the cost and logistical burden of laboratory-based methods. in many such regions, \>80% of affected children die, undiagnosed, before the age of five years. a convenient and inexpensive point-of-care test for sickle cell disease is thus crucially needed. in this study we will conduct a blinded, multicenter, prospective diagnostic accuracy study of hemotypesc(tm), an inexpensive 15-minute point-of-care immunoassay for detecting sickle cell disease, hemoglobin c disease, and trait phenotypes in newborns, children, and adults.


Eligibility criteria:
inclusion criteria: * agrees to be enrolled (or has parent/guardian approval to be enrolled) exclusion criteria: * previous sickle cell screening
multi-center molecular diagnosis and host response of respiratory viral infections in pediatric transplant recipients

Conditions: Hematopoietic Cell Transplant; Solid Organ Transplant; Respiratory Viral Infection

Summary: the participants are being asked to take part in this clinical trial, a type of research study, because the participants are scheduled to receive or have recently received a hematopoietic cell transplant (hct) or a solid organ transplant (sot). primary objective to determine if pre-transplant screening for respiratory viral load predicts rvi within 1- year post-transplant among survivors. secondary objectives: * to develop and validate a classifier based on pre-transplant immunological profile predictive of developing an acute respiratory viral infection (arvi), with rsv/piv3/hmpv/sars-cov-2 through one-year post-transplant among survivors. * to develop and validate a classifier based on day +100 post-transplant immunological profiles predictive of developing an acute respiratory viral infection (arvi),with rsv/piv3/hmpv/sars-cov-2 through one-year post-transplant among survivors .

the investigators will collect a nasal swab and blood sample from the participant when the participant is enrolled on the study and if the participant develops a rvi in the first year after transplant. the investigators will collect a blood sample 100 days after the participant's transplant.

Eligibility criteria:
recipient inclusion criteria * less than 18 years at the time of anticipated transplant * participant meets one of the following criteria: 1. scheduled to receive allogeneic hematopoietic cell transplant within 14 days of enrollment or 2. scheduled to or received solid organ transplant within 7 days before or after enrollment * participant is receiving care at the time of enrollment at one of the study participating institutions. * parent/guardian willing and able to provide informed consent, and if appropriate, child willing and able to provide informed assent. donor inclusion criteria * donor for hct recipient enrolled on the viper study. * willing and able to provide informed consent. exclusion criteria: recipient exclusion criteria none donor exclusion criteria * is not an hct donor for a participant enrolled on the viper study. * not available to provide pre-transplant research blood sample.
study of use of synera for pain during local skin infiltration with lidocaine before epidural placement

Conditions: Pain; Anxiety

Summary: local infiltration with lidocaine prior to epidural placement for cesarean section, although brief, can be painful. this pain can lead to increased anxiety and distress, adversely affecting patient's overall experience. this study proposes to examine the application of synera pain patch prior to lidocaine infiltration to reduce this pain and anxiety. the primary objective of this study is to determine the effect of the synera on maternal experience during epidural placement. the efficacy of synera pain patch in reducing subject pain during skin infiltration with lidocaine prior to epidural placement in subjects presenting for scheduled cesarean section will be assessed.


Eligibility criteria:
inclusion criteria: * over 18 years old; * undergoing pre-scheduled cesarean section; * expected singleton birth; * bmi \<=35kg.m-2; exclusion criteria: * undergoing emergency cesarean section; * complications during pregnancy; * history of hypersensitivity to study medication(lidocaine or tetracaine) or para-aminobenzoic acid; * allergies to bird proteins, feathers, or egg products; or any other skin allergies; dermatitis an open wound at the patch site or a history of difficult epidural placement;

Keywords: subject
the effects of point-of-care ultrasonography

Conditions: Chest Pain

Summary: background: when used with standard diagnostic testing, point-of-care ultrasonography (pocus) might improve the proportion of patients admitted with chest pain (cp) who are correctly diagnosed, decrease length of stay (los) in emergency department (ed) and costs. we therefore assessed pocus for the heart, lungs, aortic, hepatobiliary and deep vein in addition to the usual initial diagnostic testing in this patient population. methods: in a prospective, randomised-controlled, parallel-group trial in the ed at sakarya university training and research hospital, turkey, patients (≥18 years) with cp were randomly assigned in a 1:1 ratio to a standard diagnostic strategy (control group) or to standard diagnostic strategy supplemented with pocus (pocus group).


Eligibility criteria:
inclusion criteria: * patients admitted to the emergency were included in this study if they had chest pain, or chest pain with back pain, neck and jaw pain, abdominal pain, arm pain and shortness of breath exclusion criteria: * permanent mental disability * age younger than 18 years * having chest trauma in the last 24 hours * to be pregnant * need for urgent angiography with st elevation myocardial infarction * to be referred to the ed as a diagnosis of external center * failure to obtain complete patient information

Keywords: chest pain, pocus, length of stay, emergency department
the correlation of intracranial artery calcification and outcomes of mechanical thrombectomy

Conditions: Stroke, Acute; Ischemic Stroke; Vascular Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke; Brain Diseases; Cerebrovascular Disorders; Intracranial Arterial Calcification

Summary: cais-mt is a single-center, prospective cohort study, to evaluate the correlation between outcomes of endovascular treatment(evt) and intracranial artery calcification(iac) in patients with acute ischemic stroke due to large or medium vessel occlusion.

this study have to objective to evaluate the predictive value of iac agatston score in patients with acute ischemic stroke due to large or medium vessel occlusion on worse angiographic and functional outcomes after evt. the result of this study will provide a upfront basis for risk stratification of adverse outcomes of evt by using quantitative iac, so as to get a reference for an individualized and precise plan of evt.

Eligibility criteria:
inclusion criteria: * male or non-pregnant women with acute stroke symptoms aged over 18 years. * occlusion of the intracranial internal carotid artery, the middle cerebral artery, the anterior cerebral artery, the posterior cerebral artery, basilar artery and intracranial vertebral artery confirmed by ct, mr angiography, or digital subtraction angiography. * no absolute contraindication to iodinated contrast media. * planned treatment with evt by clinical care team. * informed consent obtained from patients or their legal representatives. * willing to be followed up as required by the clinical study protocol. exclusion criteria: * acute ischemic stroke occurs over 24 hours of time last known well. * neurologic deficits caused by diagnoses other than ischemic stroke, such as intracerebral hemorrhage, subarachnoid hemorrhage, or intracranial tumors. * with other underlying factors leading to iac, such as hyperthyroidism, end-stage renal disease, long-term oral intake of vitamin k antagonist(warfarin), chronic vitamin d deficiency or overdose, persistent hypomagnesemia, persistent hypercalcemia, persistent hyperphosphatemia and high oral calcium intake. * lack of non-contract ct images on admission and significant artifacts in ct images preventing iac measurement. * severe renal insufficiency (estimated glomerular filtration rate \ 220μmol/l (2.5mg/dl)). * previous cerebrovascular intervention treatment or craniotomy.

Keywords: acute ischemic stroke large vessel occlusion mechanical thrombectomy endovascular treatment agatston score prospective cohort study intracranial atherosclerotic disease
rct of counseling intervention on post-op opiate use

Conditions: Post-operative Pain; Opioid Use; Cesarean Section

Summary: this study is a randomized controlled trial to investigate the effect of a simple counseling intervention on post-operative narcotic requirements, with the hypothesis that women receiving this intervention will use fewer narcotics for pain management following cesarean section.

all women undergoing scheduled cesarean section at brigham and women's hospital who meet eligibility for the study will be approached in the pre-operative area on the labor and delivery floor prior to her scheduled cesarean section. for eligible patients interested in participation, consent will be obtained, and the participant will be randomized to receive either an intervention script containing counseling about post-op narcotic use, or the control script containing information regarding post-partum depression. this script will then be read to the participant in the pre-operative area prior to her scheduled cesarean section. two types of data will then be collected: inpatient data, and outpatient data. regarding inpatient data, study investigators will collect information from the electronic medical record about the quantity of narcotics used in the hospital, pain scores while in the hospital, and demographic information. in terms of outpatient data, study investigators will contact participants at 2 weeks and 6 weeks post-partum with questions from the edinburgh post-partum depression scale score and the whoqol-bref scale score, along with questions regarding their narcotic use at home. specifically, participants will be asked during the informed consent process whether they agree to 1) receive an email with a brief online survey at 2 weeks post-partum, and 2) receive a follow-up phone call within the week after the email survey was sent if survey responses are not received, 3) receive a second email with a brief online survey at 6 weeks post-partum, 4) receive a follow-up phone call within the week after the second email survey was sent if survey responses are not received. surveys will be emailed to participants using the partner's redcap service that is located behind the partner's firewall. investigators will also mine information about each participant's narcotic use from the masspat prescription monitoring database. the endpoint of the study will be enrollment of our desired sample size.

Eligibility criteria:
inclusion criteria: * delivery by scheduled cesarean section at brigham and women's hospital exclusion criteria: * answer "yes" to the question: "has any provider talked to you this pregnancy about medications for pain control after your c-section?" * history of opiate abuse * use of chronic opiates, benzodiazepines or gabapentin * history of chronic pain * cesarean hysterectomy * vertical skin incision * myomectomy at the time of cesarean section * non english-speaking * patient of the investigator performing the recruitment
multi-component breath alcohol intervention

Conditions: Alcohol Use; Alcohol Drinking; Drinking Behavior

Summary: this is the first stage of a three-stage, nih-funded study to develop and test initially a multi-modal intervention concerning blood/breath alcohol concentration for young adults. the multimodal intervention will be made up of brief telehealth counseling and psychoeducation and use of three mobile technologies to facilitate moderate drinking. in the first stage of the study, we will conduct formative research to obtain input from the study population, test initially the telehealth version of the brief counseling and psychoeducation and to develop a simple, "low tech" approach to coaching participants to use the three mobile technologies in typical drinking situations. participation will last approximately one month.


Eligibility criteria:
each subject must: 1. be between the ages of 18-25 2. be able to read english and complete study evaluations 3. report at least four days with heavy episodic drinking (i.e., 4 or more drinks for women and 5 or more drinks for men) out of the prior 30 days 4. report having consumed at least one alcoholic drink during a minimum of 12 days out of the prior 30 so that subjects will have multiple opportunities to use the moderate drinking technologies during the intervention period. 5. meet, at minimum, dsm-5 criteria for a mild alcohol use disorder (i.e., meet at least 2 diagnostic criteria) 6. self-report interest in using a smartphone app to help reduce drinking with a score of at least 3 on a 0-10 scale indicating at least a degree of openness to using technology to moderate drinking. exclusion criteria no subject may: 1. have been in inpatient or intensive outpatient treatment within the past 12 months 2. have used a smartphone application to facilitate moderate drinking more than 1 time within the past 12 months 3. meet dsm-5 criteria for current substance use disorder with the exception of tobacco use disorder, mild or moderate alcohol use disorder or mild cannabis use disorder. 4. history of alcohol withdrawal or medically-assisted detoxification as individuals with this history will likely be in need of more intensive treatment than is offered in this study. 5. be psychotic or otherwise severely psychiatrically disabled 6. report a history of a medical condition that would contraindicate the consumption of alcohol (e.g., liver disease, cardiac abnormality, pancreatitis, diabetes, neurological problems, and gastrointestinal disorders)