Kornimate/medical-research-clean huggingface dataset:
vaginal microbiota as a decisive factor in vaginal prosthetic surgery

Conditions: Pelvic Organ Prolapse

Summary: retrospective analysis of vaginal microbiota in the post-operative course of patient operated for genital prolapse with vaginal mesh with or without mesh related complication

we propose to collect vaginal specimens to obtain exfoliated mucosal cells from women who had vaginal mesh implantation for pop complicated by mesh erosion into the vagina (cases). we aim to recruit women who will receive exactly the same clinical investigations (outlined below), follow up and management. samples from patients without complications after mesh surgery will be used as controls since there are ethical difficulties in obtaining cold-cup swabs from 'normal' women and cystoscopy for conditions other than oab or usi in premenopausal women is rare. both cases and controls will be identified by the urogynaecology team based on surgical outcome reports and follow-up documentation. cases and controls will be invited to participate by the research team. relevant members of the research team (dr nikolaus veit-rubin, pr renaud detayrac, and mr vikram khullar) have extensive experience in urogynaecological investigation and pelvic floor assessment. cases and controls will be provided with an information leaflet about the study and will be asked to sign informed consent for the biopsies and a high vaginal swab will be taken. consent will be taken either a trained member of the urogynaecology team. all participants will complete the 'p-qol questionnaire" for symptoms relative to pop. clinical assessment will include a comprehensive relevant past medical history, calculation of bmi, urinalysis, standardized pop-q quantification and abdominal examination. specimens collected to be analysed will be a high vaginal swab following fully informed written consent. the specimens of vaginal swab will be processed to extract and purify the dna and then the exact bacterial genomic make up will be sequenced and analysed to identify the exact species of bacteria within the samples. further detailed protocol of the mentioned procedures is outlined in the attached protocol.

Eligibility criteria:
inclusion criteria: * females aged 18 and over who have consented for vaginal mesh surgery for pelvic organ prolapse at the the nîmes university hospital, france exclusion criteria: * pregnant or breast feeding * unwilling or unable to complete questionnaire or give valid consent.
transcriptome analysis of the peripheral blood in cidp

Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy; Autoimmune Diseases; Clarkson Syndrome; Muscular Autoimmune Disorders

Summary: chronic inflammatory demyelinating polyradiculoneuropathy (cidp) is an immune-mediated disorder of peripheral nerves. intravenous immunoglobulins (ivig) are a first line therapy for cidp. the investigators used a transcriptomic approach to compare the gene expression profiles in the peripheral blood of patients having a cidp or autoimmune diseases, before and after ivig treatment, in order to identify their mechanism of action in this condition, to lead to a better understanding of cidp pathophysiology, and potentially determine factors associated with the response to the treatment.

we study the change of the: * gene profile on transcriptome analysis of peripheral blood * t cell repertory * igg dosage * immunological profile before ivig (t1 time) and and 3 weeks after ivig treatment (t2 time). on a population of patients having: cidp, autoimmune muscular disease, clarkson syndrome, or autoimmune diseases. we also search for polymorphism of fcgammareceptor, tkpc et casp3 genes in cidp patients

Eligibility criteria:
inclusion criteria : * age ≥ 18 years old * obtained informed consent * patient having a definite or probable cidp according to efns/pns criteria or atypical cidp corresponding to patients having the efns/pns clinical criteria and at least two efns/pns supportive criteria * or * patient having a muscular autoimmune disease, or a clarkson syndrome or other autoimmune disease * currently treated by ivig exclusion criteria : * pregnancy * breastfeeding

Keywords: transcriptome analysis peripheral blood chronic inflammatory demyelinating polyradiculoneuropathy auto immune diseases ivig
prospective clinical trial of three apical sealing materials

Conditions: Periapical Abscess

Summary: this prospective comparative randomized clinical trial compares healing and bony regeneration in patients who received 1 of 3 different retrograde filling materials following microsurgical apicoectomies for the treatment of periapical lesions of endodontic origin.

a prospective comparative randomized clinical trial was designed to evaluate the healing and bony regeneration in patients who received 1 of 3 different retrograde filling materials (endosequence®, proroot® mta, or biodentine®) following microsurgical apicoectomies for the treatment of periapical lesions of endodontic origin.

Eligibility criteria:
inclusion criteria: * adult patients, american society of anesthesiologists (asa) classification i and ii * any tooth with a single chronic periapical lesion requiring apical microsurgery * informed consent signed prior to surgery exclusion criteria: * background of drug/alcohol abuse * adjacent periapical lesion * periodontal disease

Keywords: cone-beam computed tomography microsurgery bone regeneration biocompatible materials
interventions and viscoelasticity of hamstring

Conditions: Injury; Back, Lower, Superficial; Hamstring Injury; Sport Injury; Sports Physical Therapy

Summary: the study aims to investigate acute effects of ballistic hamstring stretching, hamstring extender exercise, and kinesiotaping application on viscoelasticity of hamstrings and standing long jump performance on rowers.

the study aims to investigate acute effects of ballistic hamstring stretching, hamstring extender exercise, and kinesiotaping application on viscoelasticity of hamstrings and standing long jump performance on rowers. a total of 60 professional rowing athletes were included. viscoelasticity of hamstrings were assessed by myotonpro, tallinn, estonia. athletic performance was assessed by standing long jump test (sljt). the athletes were randomly divided into ballistic hamstring stretching group (n= 20), hamstring extender exercise group (n= 20), and kinesiotape group (n= 20). for balistic hamstring stretching, athletes were asked to reach the floor in the bs group by leaning over in the standing posture without knee flexion. when they feel the tension in hamstring muscle groups, athletes were requested to make small rebounding motion at degrees between 3°-5° for half a minute. for hamstring extender exercise, athletes were asked to apply the exercise 12 repetitions and 3 sets. kinesiotaping was applied on the hamstring muscle with y shape and 25% tension force.

Eligibility criteria:
inclusion criteria: * participating to the study in a voluntary basis. * athletes with 14-18 years old. * being a rowing athlete for at least a year. * being an athlete in fenerbahce rowing team and turkish divers club - rowing branch. exclusion criteria: * having a musculoskeletal injury involving the lower extremity in the last 6 months. * having undergone a surgical operation in the last 6 months. * any limitation in lower extremity range of motion. * failing to complete the ballistic hamstring stretching, hamstring extender exercise or kinesio taping application. * wanting to quit from study.

Keywords: ballistic stretching eccentric exercise kinesiotaping viscoelasticity hamstrings athletic performance rowers
a new clinical model for the engagement of latinx youth with suicidal behavior

Conditions: Suicide Ideation; Suicidal Behaviors; Depressive Symptoms

Summary: this study will test a model of providing treatment to latinx/hispanic youth, who experience suicidal thoughts and behavior, and their caregivers. an affirmative and culturally relevant treatment will be provided to all youth and half of the families will be assigned to the additional support of a community health worker (chw). youth symptoms and family engagement to treatment will be followed for nine months. the potential benefit of adding the chw intervention will be assessed.

the objective of this proposal is to test a new clinical model to engage latinx/hispanic (l/h) youth and their caregivers in a culturally centered, evidence-based treatment for suicidal behaviors (sb). the socio-cognitive behavioral therapy for suicidal behavior (scbt-sb) is an affirmative and culturally relevant treatment with empirical evidence supporting its use for l/h youth with suicidality. the new clinical model consists of the addition of community health workers (chws) to the scbt-sb. chws are trusted members of their communities who provide education and connection to resources to l/h families in their native language. a community based participatory research approach is proposed and the socio-cultural framework for health service disparities will be the theoretical model used.

Eligibility criteria:
inclusion criteria: * latinx, defined as have been born in a latin country or having at least one biological parent, grandparent or an ancestor that was born in a latin country * severe suicidal ideation (si), defined as one of the following: * siq-jr \> 22 or endorsing any critical items (2, 3, 4, 7, 8, 9) with at least "about 1x/month" * cdi-ii \> 15 and endorsing "i think about killing myself but would not do it" or "i think about killing myself." * phq-9 \> 10 \& endorsing the item "thoughts that you would be better off dead, or of hurting yourself in some way" with a frequency of "several days" or greater or endorsing the item "has there been a time in the past month when you have had serious thoughts about ending your life? * suicidal crisis within the past 12 months * caregivers and adolescents fluent in spanish or english language and legal guardian willing to participate exclusion criteria: * participants will be referred to a different treatment program if their main clinical complaint is any of the following: * behavioral (e.g., conduct disorder, or substance use disorder) * an eating disorder * obsessive-compulsive disorder * a developmental issue (e.g., speech, occupational, families looking for assessments, treatment for autism) or a significant cognitive delay that may require specialized treatment adjustments.

Keywords: suicidal ideation suicide attempt randomized controlled trial adolescents latinx latina latino hispanic cognitive behavioral therapy depressive symptoms community health workers
agreement between clinician and instrumented laxity assessment

Conditions: Ankle Sprains; Ankle Injuries and Disorders

Summary: ankle injuries are the most common acute injury to the active population. it is important to ensure best practices and techniques used in clinics for evaluation are validated and consistent. this study will compare diagnostic outcomes of a clinician and of a diagnostic arthrometer when testing acute ankle injuries.

ankle injuries, specifically lateral ankle sprains, are the most common acute injury to the active population (hootman, dick, \& agel, 2007). it is important to insure the use of best practice and ensure that the techniques being utilized in clinics for evaluation are validated and consistent within the techniques. manual testing and instrumented testing have not yet been tested within the same cohort. the purpose of this study is to compare the diagnostic outcomes of a clinician and of a diagnostic arthrometer when testing acute ankle injuries. participants will be recruited at university of nebraska at omahas (uno) injury prevention and care clinic and athletic training room in sapp fieldhouse. participants with be members of the uno wellness center or uno athlete, aged 19-80 years old. during a standard evaluation the participant will have a clinician test manual ligamentous laxity and a blinded clinician testing laxity using an arthrometer. participation will not alter the normal treatment or care for participants. the author hypothesizes that the diagnostic accuracy for all performed test will be good to excellent when assessed for laxity and moderate to good when assessed for pain.

Eligibility criteria:
inclusion criteria: * membership to university of nebraska at omahas wellness center: a student taking on campus classes or a paying community member. acute injury occurred within one week of evaluation. exclusion criteria: * any condition that is contraindicated for manual test (i.e. fracture).
a phase i study of qlp2117 in subjects with advanced solid tumors

Conditions: Advanced Solid Tumors

Summary: this is the first in human study of qlp2117. to evaluate the safety, pharmacokinetics, immunogenicity and efficacy of qlp2117 in patients with advanced solid tumors.


Eligibility criteria:
inclusion criteria: 1. histological or cytological confirmation of recurrent or refractory advanced solid tumours, and have progressed on standard therapy, or are intolerable for available standard therapy, or there is no available standard therapy. 2. at least one measurable disease for expansion cohorts per response evaluation criteria in solid tumours (recist) v1.1(phase ia dose escalation only requires at least one assessable lesion) 3. eastern cooperative oncology group performance status of 0 or 1 4. agree to provide archived tumor tissue samples of primary or metastatic lesions. 5. have adequate organ function as described in the protocol. exclusion criteria: 1. women who are pregnant or breastfeeding 2. hbsag/hbcab positive and hbv-dna\>1000 copy/ml;hcv-ab positive and detection of hcv-rna suggested viral replication 3. is currently participating and receiving study medication in another study within 4 week prior to the first dose of study treatment 4. has an active autoimmune disease that has required systemic treatment in past 2 years. 5. has an active infection requiring systemic therapy 6. has received a live vaccine wihtin 30 days of planned start of study treatment 7. has know history of, or any evidence of interstitial lung disease
construction of diagnosis system for early ad based on multi-modality mri technology

Conditions: Mild Cognitive Impairment; Alzheimer's Disease

Summary: one purpose of this study is to construct the diagnosis system for early alzheimer's disease(ad), which is also called amnestic mild cognitive impairment (amci), and then further construct the predictable classifier from amci to ad based on multi-modality mri characteristics of amci patients.

the cognition of amci is between normal aging and dementia, which is thought the transitional stage of dementia. patients with amci have heavy risk to convert to ad, so in this study, the investigators focus on the construction of the diagnosis system for early ad based on multi-modality mri characteristics of amci patients. every patient underwent β-amyloid pet, fluorodeoxyglucose-pet(fdg-pet), structural mri, diffusion tensor imaging and functional mri. then investigators further study the patients who convert to ad and explore their mri and metabolism characteristics on baseline, in order to construct the predictable classifier from amci to ad. the investigators want to achieve the early diagnosis of ad and help clinicians interfere with the progress of this disease.

Eligibility criteria:
inclusion criteria: * memory loss complaint and confirmed by an informant * cognitive impairment in single or multiple domains, adjusted for age and education * normal or near-normal performance on general cognitive function and no or minimum impairment of daily life activities * a clinical dementia rating (cdr) score is 0.5 and consistent with the boundary of neuropsychological scale * failure to meet the criteria for dementia * must be able to accept examination of mri, sight and hearing allow to complete test * right handedness exclusion criteria: * other diseases that cause cognitive impairment, such as thyroid disease, stroke and so on * people who have severe visual and hearing impairment
chemosensitization with plerixafor plus g-csf in acute myeloid leukemia

Conditions: Leukemia, Myeloid, Acute

Summary: this study is designed to test the combination of plerixafor with g-csf for chemosensitization in patients with relapsed or refractory aml.

in this study, we are seeking to target the leukemia microenvironment to overcome disease resistance. we hypothesize that by disrupting the interaction of leukemic blasts with the bone marrow microenvironment, we may sensitize leukemic blasts to the effects of cytotoxic chemotherapy. in this study, we seek to maximize blockage of the sdf-1/cxcr4 axis through the following: 1. addition of g-csf, which down regulates sdf-1 expression and acts synergistically with plerixafor in stem cell mobilization 2. intravenous instead of subcutaneous dosing of plerixafor to improve kinetics of administration. 3. dose escalation of plerixafor and twice daily dosing to maintain maximum cxcr4 blockade.

Eligibility criteria:
inclusion criteria: 1. acute myeloid leukemia diagnosed by who criteria with one of the following: * primary refractory disease following no more than 2 cycles of induction chemotherapy * first relapse with no prior unsuccessful salvage chemotherapy 2. age between 18 and 70 years old 3. ecog performance status ≤ 3 4. adequate organ function defined as: * calculated creatinine clearance ≥ 50 ml/min * ast, alt, total bilirubin ≤ 2 x uln except when in the opinion of treating physician is due to direct involvement of leukemia (eg. hepatic infiltration or biliary obstruction due to leukemia) * left ventricular ejection fraction of ≥ 40% by muga scan or echocardiogram 5. are surgically or biologically sterile or willing to practice acceptable birth control, as follows: * females of child bearing potential must agree to abstain from sexual activity or to use a medically approved contraceptive measure/regimen during and for 3 months after the treatment period. women of child bearing potential must have a negative serum or urine pregnancy test at the time of enrollment. acceptable methods of birth control include oral contraceptive, intrauterine device (iud), transdermal/implanted or injected contraceptives and abstinence. * males must agree to abstain from sexual activity or agree to utilize a medically approved contraception method during and for 3 months after the treatment period 6. able to provide signed informed consent prior to registration on study exclusion criteria: 1. acute promyelocytic leukemia (aml with t(15;17)(q22;q11) and variants) 2. peripheral blood blast count ≥ 20 x 103 /mm3 3. active cns involvement with leukemia 4. previous treatment with mec or other regimen containing both mitoxantrone and etoposide 5. pregnant or nursing 6. received any other investigational agent or cytotoxic chemotherapy (excluding hydroxyurea) within the preceding 2 weeks 7. received colony stimulating factors filgrastim or sargramostim within 1 week or pegfilgrastim within 2 weeks of study 8. severe concurrent illness that would limit compliance with study requirements

Keywords: stem cell mobilization chemosensitization cxcr4 sdf-1 cxcl-12
the predictive value of sidestream dark field imaging in diabetic nephropathy

Conditions: Microcirculation Detection in Diabetic Patients

Summary: diabetic microangiopathy refers to the pathological changes of arterioles, capillaries and venules in diabetic patients. due to the impacts including glycol-metabolism disorder, disturbance of lipid metabolism, cytokine, oxidative stress and hemodynamic changes, the structure and function of microvessels are damaged accordingly. diabetic nephropathy (dn) is one of the most common and serious chronic microvascular complications of diabetes, and becomes a leading cause of end-stage renal failure(esrf). presently, urinary albumin/creatinine ratio (uacr) is a widely accepted and relatively reliable indicator for early diagnosis of dn, however, there are 2/3 dn patients with normal albuminuria have decreased glomerular filtration rate (glomerular filtration rate, gfr) and abnormal structure of the kidney, one the other hand, the presence of albuminuria is associated with other vascular dysfunction and kidney disease other than dn, therefore its accuracy is increasingly being challenged. sidestream dark field(sdf) imagining technology, as an emerging way to visualize blood vessels, is evaluated in a semi-quantitative manner and provides an effective means to study structure and function of microcirculation. different from biochemical markers like albuminuria, sdf provides a visual information about vessel structure, density, and quality of diffusion. at present the research of sublingual microcirculation by sdf technique is mainly applied to microcirculation monitoring in patients in the intensive care unit or laboratory animal models with acute hemorrhagic shock to assess the potential of being a tool of diagnosis and treatment prognostic indicator, no relevant research has been carried out to evaluate the predictive value of diabetic microangiopathy in literature so far. herein, the investigators designed the study based on sdf imaging to collect scientific data, thus providing strong support for the early assessment and diagnosis of diabetic nephropathy and possibly guiding individual therapy in the future.


Eligibility criteria:
inclusion criteria: * age ranges from 18 to 70 years old * signed informed consent exclusion criteria: * younger than 18 years old or older than 70 years old * shock patients who have low blood pressure under 90/60mmhg * patients with mental abnormality who are uncooperative with this study * having difficulty in mouth opening * patients with ketoacidosis * oral mucosal inflammation or injury, which could locally influence the sublingual microvasculature * pregnant or lactating women * refuse to sign informed consent

Keywords: type 2 diabetes mellitus; sidestream dark field imaging; sublingual microcirculation
measure of engagement of epilepsy patients in messaging groups

Conditions: Epilepsy

Summary: this study will measure the engagement of people with epilepsy in a mobile phone based messaging platform as well as understand if there is an impact on their self-management

the primary purpose of this study is to assess a person with epilepsy's level of usage of a mobile messaging application for peer support. the secondary purpose is to understand what characteristics of their group drive different levels of usage and improvements in self-management. participants can participate as much or little as they want for a minimum of six weeks. participants will complete an initial and a final questionnaire.

Eligibility criteria:
inclusion criteria: * age, diagnosis of epilepsy, have access to a smartphone capable of running messaging application exclusion criteria: * a diagnosis of learning disability/difficulty, significant mental health conditions; those in care, bereaved, or prisoners. any other vulnerable individuals (individuals unable to protect themselves against significant harm or exploitation)
pre/term milk profiling

Conditions: Preterm Milk; Term Milk

Summary: this study aims for an in-depth characterization of human milk of mothers who delivered prematurely to decipher differences with milk of mothers who delivered at the expected term, with a particular focus on milk proteins


Eligibility criteria:
inclusion criteria: * having obtained informed consent * group 1 (term delivery): gestational age between 37 0/7 and not above 41 6/7 weeks * group 2 (preterm delivery): gestational age between 28 0/7 and 32 6/7 weeks * age: mother ≥ 18 years old * partial or total breast feeding * having a freezer compartment at home (approx. -18°c) * good understanding of the french language exclusion criteria: * suffering from diabetes (type i or ii) before pregnancy * alcohol consumption: more than 1 standard drink / day * drug addicted * subject who cannot be expected to comply with the study procedures. * currently participating in an interventional therapeutic clinical trial