Kornimate/medical-research-clean huggingface dataset:
cardiogoniometry for detecting coronary artery disease by ct angiography

Conditions: Coronary Heart Disease; Coronary Artery Disease; Ischemic Heart Disease

Summary: cardiogoniometry is a technique to process and evaluate vectorcardiography from regular ecg acquisitions. vectorcardiography has a long tradition in cardiology for providing comprehensive information on myocardial function and integrity. in recent years, computer assisted analysis has allowed automated interpretation of vectorcardiography with promising results in comparison to standard ecg for identifying patients with coronary heart disease. this study aims to investigate the utility of cardiogoniometry for noninvasively identifying patients who are at risk from coronary heart disease.

cardiogoniometry is a technique to process and evaluate vectorcardiography from regular ecg acquisitions. vectorcardiography has a long tradition in cardiology for providing comprehensive information on myocardial function and integrity. compared to standard electrocardiography, vectorcardiography has shown to be more sensitive to detect structural and ischemic heart disease. unfortunately, the interpretation of vectorcardiography is complex which has hindered its widespread application. in recent years, computer assisted analysis has allowed automated interpretation of vectorcardiography with promising results in comparison to standard ecg for identifying patients with ischemic heart disease. however, the underlying mechanisms and threshold of altered cardiac vectors in the presence of coronary artery disease are not well understood. this research aims at exploring the relationship of computer assisted analysis of vectorcardiography with the presence, extent, severity, and location of coronary artery disease in comparison to standard ecg evaluation. furthermore, the investigators intent to follow up enrolled patients for the occurrence of adverse cardiovascular events for correlation with test findings. these data will provide comprehensive information on the diagnostic performance of noninvasive, inexpensive evaluation of cardiac vector loops for identifying patients at risk from coronary artery disease. specifically, the study aims to: 1. compare the diagnostic accuracy of cardiogoniometry with standard ecg for detecting coronary artery disease as assessed by ct angiography 2. investigate the relationship between abnormal cardiogoniometry findings and the extent/severity/location of coronary artery disease by ct angiography 3. compare the intermediate term prognosis of patients according to cardiogoniometry, standard ecg, and ct findings

Eligibility criteria:
inclusion criteria: * patients age 18 or older who are referred for elective cardiac ct examination for evaluation of coronary artery disease exclusion criteria: * hemodynamic instability * history of anaphylactic contrast reaction * inability of following breath hold instructions
the impulse study: pilot

Conditions: Chronic Heart Failure

Summary: continuous-flow (cf) left ventricular assist devices (lvads) are an important tool in the treatment of end-stage heart failure, affording patients significantly improved quantity and quality of life. in recent years, tens of thousands of lvads have been implanted worldwide, with nearly 1,000 at the texas heart institute (thi). despite the benefits from lvad therapy, one major weakness is the high frequency of late strokes, reported up to 19%. cf lvads minimize or remove the pulsatility within the blood system, introducing a new and incompletely understood physiology. increased sympathetic ("fight or flight" nervous system) tone secondary to lack of pulse in the blood system can cause high blood pressure, with subsequent hemorrhaging strokes (bleeding into the brain) are one possible explanation for this high adverse event rate in cf lvad patients. a simple intervention to decrease the increased sympathetic tone is called "ischemic conditioning"; a sphygmomanometer (blood pressure cuff) is placed on the patient's arm to compress a major artery (ischemia) with subsequent release of the cuff (reperfusion) for set periods of time. this has been shown to reduce blood pressure and major adverse cardiovascular events in other patient populations. we plan to conduct a trial to evaluate this intervention, ischemic conditioning, in patients with cf lvads. we hypothesize that ic will cause a reduction in blood pressure and strokes in this patient population.


Eligibility criteria:
inclusion criteria: * continuous flow lvad and able to provide informed consent and comply with follow-up exclusion criteria: * \< 18 years of age

Keywords: left ventricular assist device continuous flow remote ischemic conditioning hypertension sympathetic tone endothelial dysfunction
cognitive rehabilitation in post-covid-19 syndrome

Conditions: Post-COVID-19 Syndrome

Summary: the first aim of this study is to determine the feasibility of delivering co-op remotely to individuals experiencing cognitive impairments that limit everyday activities in post-covid-19 syndrome (pcs). the second aim of this study is to assess the effect of co-op on activity performance, subjective and objective cognition, and quality of life in a sample of individuals with pcs. the research team hypothesizes that effect size estimations will indicate that co-op will have a greater positive effect, compared to an inactive control group, on activity performance, subjective and objective cognition, and quality of life in a sample of individuals who self-report pcs and cognitive impairment.

post-covid-19 symptoms (pcs) cognitive symptoms require the rehabilitation community to investigate ways to: (1) reduce the functional impact of the symptoms on daily life and (2) support individuals with pcs to establish new habits to improve and maintain health. while the cognitive impairment associated with pcs has not been well evaluated, it is similar of cognitive symptoms seen in other conditions. metacognitive strategy training (mcst) approaches are an evidence-based practice standard for improving capacity to self-manage chronic cognitive symptoms and reduce their functional impact on everyday life activities. the co-op approach is an mcst intervention in which participants are taught a general cognitive strategy that can be applied in known and novel contexts to devise task specific strategies for engaging in an activity. existing evidence with other populations suggests that co-op has more of a positive effect on improving activity performance and cognition than remediation/retraining-based approaches. these effects have been demonstrated in individuals with mild cognitive impairment that mirrors that found in pcs. the overall research hypothesis is that co-op can feasibly be administered remotely and will improve activity performance, subjective and objective cognitive function, and quality of life in individuals with pcs.

Eligibility criteria:
inclusion criteria: * self-reported cognitive symptoms persisting for at least 6 weeks following covid-19 infection (cognitive failures questionnaire (cfq) score \>43) * self-identified activity performance goals per the canadian occupational performance measure (copm) * documented prior diagnosis of covid-19 * read, write, and speak english fluently * ability to provide valid informed electronic consent exclusion criteria: * diagnosis of severe neurological or psychiatric condition(s) * dementia symptoms as indicated by a score of \<23 on the montreal cognitive assessment (moca) * untreated sleep apnea (≥5 on the stopbang) * prior cancer treatment * severe depressive symptoms (\>21 on the patient health questionnaire-9)

Keywords: covid-19 metacognition cognition telehealth activities of daily living
a research study to compare how much of the medicine nnc0519-0130 is in the blood of people with overweight or obesity who receive 2 preparations of the medicine

Conditions: Obesity

Summary: this study will look into a new study medicine called nnc0519-0130 to improve the treatment option for people living with excess body weight or type 2 diabetes or both. the purpose of this study is to compare the amount of nnc0519-0130 in the blood of participants who have excess body weight. the study comprises two parts and the participants will receive both preparations nnc0519-0130 b and nnc0519-0130 c, which treatment the participants get is decided by chance. the study will last for about 24 weeks.


Eligibility criteria:
inclusion criteria: * male or female of non-childbearing potential. * age 18-64 years (both inclusive) at the time of signing the informed consent. * body mass index (bmi) between 27.0 kilogram per square meter (kg/m\^2) and 39.9 kg/m\^2 (both inclusive) at screening. overweight should be due to excess adipose tissue, as judged by the investigator. * considered eligible based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judged by the investigator. exclusion criteria: * any condition which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol. * glycated hemoglobin (hba1c) greater than or equal to (≥) 6.5 % (48 millimoles per mole \[mmol/mol\]) at screening. * use of prescription medicinal products or nonprescription drugs, except routine vitamins, occasional use of acetaminophen, ibuprofen, acetylsalicylic acid, or topical medication (including eye drops for pupil dilation) not reaching systemic circulation, within 14 days before screening. * presence or history of any clinically relevant respiratory, metabolic, renal, hepatic, cardiovascular, gastrointestinal, or endocrinological conditions.
left main percutaneous coronary intervention registry in istanbul medipol university hospital

Conditions: Coronary Artery Disease; Left Main Coronary Artery Disease

Summary: this hospital-based registry study at istanbul medipol university hospital focuses on documenting and analyzing the clinical and demographic characteristics, procedural-related aspects, and both short and long-term outcomes of patients undergoing left main coronary artery percutaneous coronary intervention (pci). the study aims to identify predictors for adverse clinical outcomes in patients treated for left main coronary artery disease.


Eligibility criteria:
inclusion criteria: * all patients undergoing any pci procedure(s) in given timeframe will be included in this registry exclusion criteria: * patients with no informed consent
occipital transcutaneous stimulation in chronic migraine

Conditions: Chronic Migraine

Summary: this study evaluates the effect in chronic migraine patients of daily 20 minute-transcutaneous sub occipital neurostimulation using the occipital cefaly° device.

chronic migraine is a disabling neurological condition affecting 0.5-2% of the population. cm is difficult to treat and preventive treatment options are limited. due to the inefficiency of available and the lack of new preventive anti-migraine drug, neurostimulation methods have raised great interest in recent years. the onstim study showed a reduction in headache frequency in 39% of patients treated with active ons during 12 weeks, compared to no improvement in the "non-effectively" stimulated or medically treated groups.

Eligibility criteria:
inclusion criteria: * diagnosis of chronic migraine (ichd iii beta 1.3) with or without medication overuse exclusion criteria: * other diseases
neuropathic pain after lung surgery

Conditions: Chronic Neuropathic Pain, Postoperative; Chronic Pain, Postoperative; Chronic Chemotherapy-induced Neuropathic Pain; Chronic Chemotherapy-induced Pain; Chronic Chemotherapy-induced Peripheral Neuropathy

Summary: to understand pain pathophysiology in terms of risk factors and protective mechanisms ranging from molecular pathways to societal impacts.

pain and loss of function are intimately associated with the reaction of the nervous system to neural damage. a lesion to the somatosensory nervous system caused by mechanical trauma, metabolic disease, neurotoxic chemicals, infection or tumor invasion may give rise to neuropathic pain. neuropathic pain affects around 8% of the population and may negatively impact the individual's quality of life; moreover, the condition leads to significant costs to the healthcare system and society. not all subjects with such a lesion develop neuropathic pain, and those who do develop neuropathic pain have varying degrees of symptom severity, impact and outcomes and may respond unpredictably to treatment. the interaction between genetics and environmental and clinical factors in a susceptible individual most likely contribute to the variation in pain prevalence and severity. a better understanding of the exact nature of these risk factors and their interactions will ultimately improve the patients' health, both in terms of recognizing patients at risk and identifying new treatment modalities. genetic, neurophysiological and psychological factors all influence the risk of developing persistent pain. it is therefore possible to describe a genetic, neurophysiological and psychological profile, in particular in patients experiencing neuropathic pain after surgery and/or neurotoxic chemotherapy.

Eligibility criteria:
inclusion criteria: * male and female subjects. * age ≥18 years. * patients scheduled for lung cancer resection performed via thoracoscopy and/or thoracotomy, including lobectomy, bilobectomy, pneumonectomy, resection of the tracheobronchial bifurcation, wedge resection, sleeve resection and combinations hereof. * willingness and ability to comply with study procedures as judged by the site investigator/manager. * expected availability for follow-up throughout the study, i.e., \~12 months. * willingness to voluntarily sign and date the study-specific informed consent form. exclusion criteria: * mental incapacity or language barriers precluding adequate understanding of study procedures. * current alcohol or substance abuse according to the site investigator's medical judgement. * unsuitability for participation in the study for any other reason, e.g. due to a significant serious underlying condition (e.g. other cancer or aids), as determined by the site investigator/manager.
electro-thumbtack needle therapy for chronic neck pain

Conditions: Neck Pain

Summary: this prospective trial will be a single-center, participant-blinded, randomized controlled trial. it is reported in previous studies that both acupuncture and transcutaneous electrical nerve stimulation are effective in reducing neck pain comparing to placebo or exercise. taking into account the convenience of electro-thumbtack needle therapy shown in clinical practice, this study aims to evaluate the efficacy and safety of electro-thumbtack needle therapy for alleviating chronic neck pain compared with sham electro-thumbtack needle therapy.

chronic neck pain is a commonly experienced symptom that often influences work efficiency and life satisfaction for years. a total of 180 participants suffering mechanical chronic neck pain will be recruited and randomized into either electro-thumbtack needle therapy group or sham electro-thumbtack needle therapy group. all participants will receive the standardized neck exercise instruction at their first treatment session and will be asked to perform the exercise once every day during 4-week treatment. all assessments will be performed by the assessor and the assessment results will be all kept from the acupuncturist. the statistician will be involved in neither assessment nor treatment and will be blinded regarding intervention group code.

Eligibility criteria:
inclusion criteria: 1. diagnosed with neck pain with headaches or neck pain with movement coordination impairments according to the orthopaedic section of the american physical therapy association (apta); 2. aaged 18-65 years; 3. history of neck pain for at least 3 months; 4. a score of ≥4 in numerical rating scale for neck pain (nrs-np) assessing the average neck pain intensity over last 7 days until the day of recruitment. exclusion criteria: 1. diagnosed with neck pain with mobility deficits or neck pain with radiating pain according to the orthopaedic section, apta; 2. known specific reason leading to neck pain such as tumor, immune disease, endocrine and metabolic disorders, neurological abnormalities, cervical vertebra fracture, cervical dislocation; 3. acute neck pain or neck pain with radiating pain or upper limb symptoms; 4. neck pain with sensory or motor disturbance; 5. prior cervical spine surgery or congenital abnormalities; 6. experiencing medical dispute litigation; 7. have received acupuncture in last 30 days; 8. in need of analgesic, muscle relaxant, hormones, or bearing greater pain from another area; 9. allergic to metal or adhesive tape, or carrying cardiac pacemaker, or skin damaged at selected acupoints; 10. disable to communicate or critically ill; 11. drug or alcohol dependent; 12. currently or planning to be pregnant.
the effect of obesity on oral peri-implant health - a cross-sectional study

Conditions: Obesity; Peri-implant Inflammation; Peri-implantitis

Summary: in recent years, greater emphasis has been placed on the link between oral and systemic health. obesity, a growing medical problem worldwide, has been associated with multiple chronic inflammatory diseases such as diabetes mellitus and cardiovascular disease. with respect to the effect of obesity on periodontal health, it has been shown that obese subjects exhibit higher inflammation around natural teeth and are at increased risk of tooth loss than individuals with normal weight. peri-implantitis, an inflammatory condition of bacterial origin that occurs around oral implants and resembles periodontal disease, has become a serious concern for the dental profession given its increasing prevalence and challenging treatment. there is also strong evidence that individuals with a history of periodontitis are also at risk for peri-implantitis. however, knowledge about the pathogenesis and treatment of peri-implantitis is scarce. hence, it is extremely important to understand the implications of excessive body fat on peri-implant health. based on the current understanding on the effect of obesity on systemic and local inflammation around natural teeth, the investigators hypothesize that obesity will have a significant impact on peri-implant health by inducing an increased inflammatory response as measured by clinical as well as molecular markers of inflammation.


Eligibility criteria:
inclusion criteria: * adults (18 years or older) * currently non-smokers * subjects in maintenance care with adequate dental plaque control (\<20% plaque index according to o'leary et al. 1972) * subjects with at least one rough surface titanium oral implant in function for at least 6 months. exclusion criteria: * edentulous subjects or subjects presenting with blade-type implants and/or implants with smooth surface. * pregnant or nursing women * subjects who have taken medications that are known to alter the oral inflammatory status, such as antibiotics and anti-inflammatory agents, for 3 months prior to the study. * subjects with a history of aggressive periodontitis (as defined by the american academy of periodontology).
how variations in pharmacogenomic profiles affect pain and narcotic needs following total knee arthroplasty (tka)

Conditions: Knee Osteoarthritis; Total Knee Arthroplasty (TKA)

Summary: the purpose of the study is to gain a better understanding of how genetic variations can affect pain experience and the need and type of pain control medication after a total knee replacement.

the purpose of the study is to gain a better understanding of how genetic variations can affect pain experience and the need and type of pain control medication after a total knee replacement. people experience pain differently. the type and amount of medication required to control pain varies. post-operative pain often requires narcotics to keep patients comfortable. it has been shown that there is a genetic difference in how people respond to pain and how they respond to the medications used for the relief of pain. opioids are often used to relieve pain after surgery. these medications can be abused and have had a role in the current opioid crisis. pharmacogenomics is the study of how patients respond to and metabolize drugs and medications based on their genetic profiles. this study will collect data on the pain experienced by participants and the narcotics used after total knee replacements. this will be correlated with the participants' pharmacogenomic profiles obtained though dna testing. there are no treatment interventions in this study. although a pharmacogenomic profile will be obtained at the first post-operative visit and reported approximately 3 weeks later, the subject will have completed the need for pain relief. the study is expected to last 2 years with 300 subjects enrolled.

Eligibility criteria:
inclusion criteria: * age 18 or older * unilateral primary total knee arthroscopy (tka) * knee osteoarthritis * planned discharge to home exclusion criteria: * unicompartmental total knee arthroscopy (tka) * revision total knee arthroscopy (tka) * knee flexion contracture \> 15° * axial deformity \> 15° * previous or current chronic narcotic use for pain \> 3 months * previous or current substance abuse * any chronic pain condition * any dementia or cognitive disorder * discharge to skilled nursing facility * rheumatoid arthritis * potential difficulty completing daily pain scores and medication use * previous northshore genotyping * currently taking cyp2d6 inhibitors (list in appendix) * currently taking cyp2d6 inducers (list in appendix)

Keywords: pharmacogenomic profile knee osteoarthritis total knee arthroplasty (tka) narcotic use
nifr image-guided surgery for malignant soft tissue tumor with low-dose swig technique

Conditions: Dermatofibrosarcoma Protuberans (DFSP); Skin Squamous Cell Carcinoma

Summary: this research study will evaluate how near-infrared fluorescence (nirf) imaging with low-dose second window indocyanine green (icg) can assist in the radical resection and pathologic diagnosis of malignant soft tissue sarcoma, such as dermatofibrosarcoma protuberans (dfsp) and skin squamous cell carcinoma (sscc) during surgery.

to improve the accuracy of radical resection by reducing the risk of missed diagnosis of positive margin, this study will explore clinical application of near-infrared fluorescence imaging with modified low-dose swig technique in guiding radical resection of malignant soft tissue tumor. the investigators conduct a multi-center, multi-subgroup, prospective randomized controlled trial. the participants will be first stratified according to histological type involving dermatofibrosarcoma protuberans (dfsp) and skin squamous cell carcinoma (sscc). the patients with dfsp or sscc will be then randomly assigned to three groups. patients in the control group will not receive icg administration. the icg was injected intravenously 24 hours before surgery, at a dose of 0.25 mg/kg in the first experimental group and 25 mg/patient in the second experimental group, respectively. the patients in the control groups will undergo traditional assessment of surgical margins.the patients in the experimental groups, on the other hand, will be scheduled to intraoperative near-infrared fluorescence imaging to scan gross tumor, tumor bed and cross-sectional specimen. the 2-year local recurrence rate will be regarded as primary outcome. the number of positive margins will be compared among groups. the investigators will also calculate the sensitivity, specificity, positive predictive value (ppv) and negative predictive value (npv) with 95% confidence intervals based on fluorescent signal of tumor bed in the experimental groups.

Eligibility criteria:
inclusion criteria: * patients with dfsps or sscc in heads, extremities or trunk exclusion criteria: * seafood/iodine allergy * hyperthyroidism * pregnancy * myasthenia gravis * acute severe hypertension

Keywords: near-infrared fluorescence imaging second window indocyanine green dermatofibrosarcoma protuberans skin squamous cell carcinoma