Kornimate/medical-research-clean huggingface dataset:
sodium, nocturnal blood pressure and nocturnal pauses in breathing

Conditions: Sodium Imbalance; Nocturnal Blood Pressure; Obstructive Sleep Apnea of Adult

Summary: a reduction of dietary sodium intake reduces blood pressure and risk of cardiovascular disease.

a reduction of dietary sodium intake reduces blood pressure and risk of cardiovascular disease. patients with hypertension resistant of antihypertensive treatment have a high frequency of non-dipping and obstructive sleep apnoea (osa). the aim of this project is to analyse the effect of dietary sodium restriction on nocturnal blood pressure and nocturnal pauses in breathing in this patients population.

Eligibility criteria:
inclusion criteria: * 24h blood pressure \> 130/80 mmhg under antihypertensive treatment with three agent, one of these being diuretic. blood pressure measurement completed after observed intake of antihypertensive medication. * unchanged antihypertensive treatment for three months * estimated glomerular function \>45 ml/min/1.73 m2 exclusion criteria: * heart failure assessed from nyha classification (grade 3-4) * presence of clinically significant peripheral edema * in treatment for obstructive sleep apnea * chronic obstructive pulmonary disease (fev1 \<50%) * antihypertensive therapy that can not be taken once daily * pregnancy or breastfeeding * β-albumin \<34 g / l * u-albumin creatinine ratio\> 1000 mg / g * inr\> 1.2 (if marevan treatment: alat\> 200) * gluten allergy (dietary guidelines are not adjusted to this group)
head-down position for acute ischemic stroke with large artery atherosclerosis

Conditions: Ischemic Stroke

Summary: currently, the guideline recommended re-perfusion such as intravenous thrombolysis and mechanical thrombectomy as the most effective treatment for acute ischemic stroke. however, the two methods are restricted by a strict time window, which greatly limits the number of the patients receiving treatment. the abundant studies have suggested that good collateral circulation can provide compensatory blood supply to save the ischemic penumbra and reduces the infarct volume, which improves the prognosis. how to improve collateral circulation in an efficient and safe way is a clinical challenge. our recent experiment results of the animal and preliminary clinical experiments show that head-down position may significantly increase cerebral perfusion and improve neurological function. clinically, head-down position is simple and easy to operate, and theoretically may increases brain perfusion and improve collateral circulation. a pilot randomized clinical trial is designed to investigate the effect of head-down position combined with routine rehabilitation in patients with ischemic stroke.the study is designed to explore the efficacy and safety of head-down position in patients with acute ischemic stroke


Eligibility criteria:
inclusion criteria: 1. patient age over 18 years 2. acute ischemic stroke within 24 h of onset 3. neurological deficit: 6≤nihss≤16 4. large artery atherosclerosis etiology based on toast typing 5. the supplied vessel is the middle cerebral artery or internal carotid artery, and the degree of stenosis was more than 50%. 6. first stroke onset or past stroke without obvious neurological deficit (mrs≤1) 7. signed informed consent exclusion criteria: 1. disturbance of consciousness 2. hemorrhagic stroke or mixed stroke 3. combining with severe organ dysfunction 4. past hemorrhagic stroke 5. a history of stroke with severe sequelae 6. planned revascularization within 3 months 7. ischemic stroke due to surgical intervention 8. participating in other clinical trials within 3 months 9. pregnant or lactating women 10. any inappropriate patient assessed by the researcher

Keywords: head-down position large artery atherosclerosis
compensatory brain mechanisms for amygdala-associated cognitive dysfunction: potential role of the cortical mirror neuron system

Conditions: Healthy

Summary: identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional mri.

in the present study, investigators aim to investigate amygdala dysfunction \& potential compensation in individuals with high and low traits (e.g. autism, anxiety, depression traits, alexithymia), high and low stress or protective factors in the environment (social network, early life stress) and different molecular genetic make-up. on the neural level, functional and structural connectivity as well as task-related bold activation will be assessed.

Eligibility criteria:
inclusion criteria: * healthy subjects exclusion criteria: * history of head injury * claustrophobia; * medical or psychiatric illness * female subjects were pregnant or taking oral contraceptives. * taking any form of medication and drunk any caffeine-containing beverages on the day of the experiment.

Keywords: amygdala mirror neuron system brain network
study to compare reduction in pain after surgery with and without local anesthesia during laparoscopy

Conditions: Post Operative Pain

Summary: this study will help to answer the question, "does injecting local anesthetic before laparoscopic instrument ports are placed decrease pain after surgery?" patients participating will be randomly assigned to receive local anesthetic or saline injection at the site of a laparoscopic instrument port as part of their planned surgery. after surgery at 4 and 24 hours the patient will be asked to rate their pain on a simple chart.

the literature is divided on the efficacy of preincisional local analgesia injections at laparoscopic port sites to decrease post operative pain. one reason for this lack of a clear conclusion is the fact that prior studies included small and large port sizes. many small port sites have little pain associated with them so showing a reduction with medicine is statistically difficult. the investigators have noted that larger, lateral port sites which require fascial closure are the sites that patients consistently note pain at. our protocol will include the use of 0.25% marcaine injections at all the surgical ports other than the large lateral port used for gynecologic laparoscopy. patients would then be randomized and surgeons would be blinded as to which patients receive the marcaine or a saline injection at the large lateral port site. visual analog pain scales will be assessed at 4 and 24 hours after surgery. an additional two arms have been added to include 50 patients randomized to 0.25% marcaine or saline injection just prior to incisional closure in the absence of any preincisional intervention.

Eligibility criteria:
inclusion criteria: * patients undergoing laparoscopic surgery exclusion criteria: * cardiovascular instability * malignancies * pulmonary conditions incompatible with laparoscopic surgery

Keywords: pain laparoscopy reduction
identification of clinically relevant markers of deep brain stimulation electrode impedance

Conditions: Parkinson Disease

Summary: the study will look into the changes of deep brain stimulation (dbs) measured impedances in patients of parkinson disease (pd) as a function of their functional state (lying, sitting and walking) and dopaminergic medication intake (levodopa or dopamine agonists). the goal is to use dbs measured impedance as a surrogate of the functional and medication states of pd patients.

subjects will be recruited from the population of patients who are already implanted with dbs for treatment of pd. at the patient's follow up visit they will be asked to come to the clinic in the "off medication" state. off medication is defined as at least 8 hours since the last medication dosing. data will be collected during three phases: "off" state, transitioning state, and "on" state. subjects will be asked to assume different functional states (lying, sitting or walking) for 1 minute each. during these functional states, multiple measures of impedance will be collected. * "off" state data collection: the subject will be examined to assess his motor examination score using the updrs-iii. measurements of impedance will be collected multiple times in the lying down and sitting up states. * transition state data collection: the subject will be asked to take their dopamine medication. the medication will take approximately 1 hour to take full effect. measurements of impedance will be collected every 10 minutes during this transition from the "off" state to the "on" state. patients will be asked to report at what point they felt the "on: state (they can report the state as "off", "unsure", "transition" or "on"). * "on" state data collection: the "on" state examination will start after 1 hour from medication administration. subjects will be examined using the updrs-iii. measurements of impedance will be collected in the lying down, sitting and walking states. summary of the study protocol: "off" state transition state "on' state updrs-iii x x impedance lying down x x sitting up x x x walking x updrs i and ii x hoehn and yahr x x

Eligibility criteria:
inclusion criteria: * idiopathic parkinson's patients with dbs (unilateral or bilateral) * must be taking dopamine agonist or levodopa regimen * medtronic neurostimulator activa sc, pc or pc+s (ipg) exclusion criteria: * hoehn and yahr (h\&y) 4 and above * history of dbs revision or lead replacement surgery * current or prior non-medtronic activa sc, pc or pc+s ipg * historical information of more than 1 hour delay to "on" state as average

Keywords: deep brain stimulation electric impedance parkinson disease
retinoic acid supplementation and subjects with hypercholesterolemia

Conditions: Hypercholesterolemia

Summary: the aim of the study is to investigate the effects of retinoic acid on the hdl-pon1 activity and cholesterol efflux capacity in hypercholesterolemic subjects.

paraoxonase 1 (pon1), an enzyme associated with high-density lipoprotein, is reported to have antioxidant and cardioprotective properties. and all-trans-retinoic acid revealed the ameliorating atherosclerosis effects in many reports.there maybe some correlations between retinoic acid and pon1 activity and the study aim to prove it.

Eligibility criteria:
inclusion criteria: * subject has a fasting total cholesterol concentration between 200 and 310mg/dl. * subject is between 25 and 65 years of age, inclusive. * subjects' bmi is between 18.5 kg/m2 and 35 kg/m2. exclusion criteria: * subject that is pregnant. * subject that has coronafy artery desease, diabetes mellitus, thyroid disorders, mental disorder, cancer, cirrhosis, renal disease and hepatic desease. * subject that has had operation less than six months prior to screening visit. * subject that is smoking. * subject uses any drugs that could influence the measurement of lipid paramerters or inflammatiory makers.
osteoarticular tumor characterization by advanced imaging

Conditions: Bone Tumor; Soft Tissue Tumor

Summary: the purpose is to compare and evaluate multiple functional imaging methods (perfusion, diffusion, spectroscopy) for initial benign/malignant characterization of osteoarticular tumors and to determine which method or which association of methods could improve non invasive tissue characterization. secondary purposes are: * to determine a possible correlation between some parameters and the histological grade (fnclcc) * to suggest a coherent diagnostic imaging approach for osteoarticular tumors. the ancillary study will enroll patients needing radiological tumor follow-up. the purpose is to identify tools for evaluation of tumor activity and therapeutic response before modification of morpho-volumetric data.

patients refered for the initial evaluation of suspected osteoarticular masses will be included in this study after signing an informed consent. histologic analysis will be used as a gold standard. the following imaging techniques will be evaluated: * contrast enhanced ultrasonography * low dose ct perfusion * magnetic resonance perfusion * diffusion weighted imaging * magnetic resonance proton spectroscopy

Eligibility criteria:
inclusion criteria: * patients examined for initial assessment of bone or peripheral soft-tissue primitive tumor * patients with normal awareness level * patients having signed informed consent exclusion criteria: * pregnant women * persons deprived of liberty * persons under legal protection or unable to give informed consent * persons in life-threatening emergency * allergy to sonovue, iodinated contrast media or gadolinium chelates * risk of pregnancy * breastfeeding women * acute coronary syndrome or unstable ischemic cardiopathy (ban on injection of contrast agent for ct scan) * renal failure (ban on injection of contrast agent for mri and ct scan) * contraindication to mri

Keywords: mr imaging diffusion weighted imaging mr proton spectroscopy ct perfusion contrast enhanced ultrasound
motivational interviewing and physical activity change in parkinson's disease

Conditions: Parkinson Disease

Summary: the purpose of this study is to test the efficacy of a 6-month telephone-based motivational interviewing intervention and a web-based application intervention to improve physical activity in participants with parkinson's disease.

participants will be randomized into one of four groups to examine two separate interventions. the groups are: motivational interviewing (a counseling/coaching style), a web-based application for participants to keep track of their physical activity, a combination of the motivational interviewing and the web-based application, and an educational program on various issues related to parkinson's disease. the intervention will last 6 months with a follow-up appointment at 9 months. participants will be asked to come to galter pavilion at northwestern memorial hospital or shirley ryan abilitylab a total of five times over the course of the nine months.

Eligibility criteria:
inclusion criteria: * community dwelling * age 18 or older * physician confirmed diagnosis of pd with hoehn and yahr stage ≤3 * ability to ambulate independently (walker is allowed) for distance of 50 feet or 10 minutes at a time * does not meet current cdc physical activity guidelines of 150 minutes of moderate to vigorous physical activity per week * currently and plans to have a smartphone, tablet, or computer and access to the internet for the next 9 months * willing to monitor activity on their smartphone, tablet, or computer via a web-based application during the 9-month program * currently uses the internet in a basic capacity exclusion criteria: * inability to speak and understand english * has a cardiovascular disorder or other health condition that would make exercise unsafe according to their physician * patients who are currently receiving physical therapy or received physical therapy one month prior to study enrollment * cognitive impairment as defined by inability to provide informed consent and to self-report feelings and behaviors * montreal cognition scale (moca): rating of less than 24, indicative of cognitive dysfunction * patients who indicate it is not recommended they participate in increased physical activity as indicated by the physical activity restriction questionnaire (par-q) * patients who are in other studies that monitor fitness or physical activity

Keywords: parkinson's disease parkinson's motivational interviewing exercise motivation
zika case definition and surveillance study

Conditions: Zika Virus Disease

Summary: this prospective, surveillance study will assess the operational zika virus definition for use in future zika purified inactivated virus (zikv) vaccine efficacy trials in order to identify zika virus disease (zvd) cases among the study cohort.

this prospective, multicenter, cohort study will conduct active and passive surveillance for zvd and determine its prevalence and seroconversion incidence in areas of latin america experiencing zika epidemic activity. a description of the occurrence of dengue virus and chikungunya virus infections in the cohort may also be provided as differential diagnosis of zvd.

Eligibility criteria:
inclusion criteria: 1. aged 15 to 40 years on the day of inclusion, currently residing in the site zone, and planning to continue to reside in the site zone for the duration of the study 2. for subjects under the age of majority on the day of inclusion: the assent form has been signed and dated by the subject (if required by local regulations), and the informed consent form has been signed and dated by the parent(s) or legal guardian(s). for subjects at or over the age of majority on the day of inclusion: the informed consent form has been signed and dated. 3) subject (and parent/guardian if subject is under the age of majority) able to attend all scheduled visits and to comply with all study procedures 4) in good health, based on medical history and physical examination exclusion criteria: 1. subject is pregnant (as self-reported) 2. participation in the 4 weeks preceding enrollment, or planned participation during the present study period, in a clinical trial investigating a vaccine, drug, medical device, or a medical procedure 3. receipt of any dengue or yellow fever vaccine in the 4 weeks preceding the day of enrollment or planned receipt of any dengue or yellow fever vaccine during the study period 4. receipt of immune globulins, blood or blood-derived products in the past 3 months 5. known or suspected congenital or acquired immunodeficiency; or receipt of immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding 6 months; or long-term systemic corticosteroids therapy (prednisone or equivalent for more than 2 consecutive weeks within the past 3 months) 6. history of zika virus disease, confirmed either clinically, serologically, or virologically 7. chronic illness that, in the opinion of the investigator, is at a stage where it might interfere with study conduct or completion 8. current alcohol abuse or drug addiction 9. deprived of freedom by administrative or court order, or in an emergency setting, or hospitalized involuntarily 10. identified as an investigator or an employee of the investigator or study center, with direct involvement in the proposed study, or identified as an immediate family member (i.e., parent, spouse, natural or adopted child) of the investigator or employee with direct involvement in the proposed study.

Keywords: zika virus disease
cerclage for twins with short cervix

Conditions: Preterm Birth; Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2; Cervical Incompetence; Cervical Shortening

Summary: a prospective randomized control trial that will compare cervical cerclage plus vaginal progesterone to vaginal progesterone along in twin pregnancies complicate by a short cervix (\</= 15.0mm) between 16w0d to 25w6d.

a prospective randomized trial that will test whether treatment with cervical cerclage plus vaginal progesterone improves pregnancy outcomes among women with twin pregnancy at 16 0/7 to 25 6/7 weeks of gestation who have a cervical length (cl) of 0.1 to 15.0 mm on transvaginal ultrasound exam, the rate of preterm birth at less than 32 weeks of gestation (ptb\<32 wks.) and the rate of adverse perinatal outcome will be lower in those treated with cervical cerclage plus vaginal progesterone than in those treated with vaginal progesterone alone.

Eligibility criteria:
inclusion criteria: * twin pregnancy (see exclusion criterion (a) below re: monochorionic twins) * gestational age 16 0/7 to 25 6/7 weeks at time of enrollment by best-estimated age. * cervical length 0.1 to 15.0 mm on transvaginal ultrasound examination. (cervical length is taken to mean the length of the closed portion of the cervical canal. exclusion criteria: * maternal age less than 18 years * monochorionic twins (such as monochorionic-diamniotic, monochorionic-monoamniotic, or conjoined twins) * rupture of membranes, either twin * one or both twins has no cardiac activity * one or both twins has known or suspected major malformation, aneuploidy, or polyhydramnios * maternal congenital uterine anomaly (such as bicornuate uterus, unicornuate uterus) * pregnancy started as triplets or higher-order multifetal gestation and then reduced to twins, either spontaneously or via procedure * symptomatic uterine contractions, 6 or more per hour * ongoing bleeding from uterus * patient declines to consider cerclage * patient declines treatment with vaginal progesterone * allergy to progesterone or peanuts (because the vaginal progesterone formulation used will be a capsule of micronized progesterone in peanut oil.) * cerclage is already in place * cerclage placement is judged to be technically impossible * patient has a history of poor follow-up or poor adherence to physician recommendations * patient is planning to relocate outside the local area before the end of pregnancy such that delivery records will be unavailable * patient does not give consent to participate in this trial.

Keywords: cerclage cervical shortening twins progesterone
hybrid funnel technique a innovative technique for implant site preparation

Conditions: Missing Teeth; Edentulous Alveolar Ridge; Tooth Loss

Summary: hybrid funnel technique arises from the union of subtractive and non-subtractive techniques for implant site preparation. hybrid funnel technique is performed with specially designed drills and osteotome. the aim of the study is to examine marginal bone level and implant stability of implants inserted with two different techniques for the surgical implant site preparation.

overtime several osteotomy techniques were described in literature for surgical implant site preparation and there is a clear dichotomy between expansive and ablative techniques. the ablative techniques imply the preparation of the implant socket by removing bone: drill osteotomy and ultrasonic osteotomy. expansive technique for osteotomy has recently been proposed: the osseodensification. osseodensification, a non-subtractive instrumentation method, involves the use of specific drills or manual osteotomes which determine an expansion of the implant site without bone removal and bone fragments compaction on the walls of implant socket.the aim of the present study is to propose a new approach for the implant site preparation that combines ablative and expansive techniques. the technique proposed is called hybrid funnel techniquealthough a variety of techniques are available for implant site preparation, the hypothesis is that hybrid funnel technique will be positively adopted to perform osteotomy, exploiting the cancellous bone elastic properties to stabilize the implant and avoiding to stress the cortical area. primary objectives are to compare hybrid funnel technique and traditional technique on different bone densities and to examine marginal bone level torque insertion value and implant stability.

Eligibility criteria:
inclusion criteria: 1. patient needing for post-extraction implant supported restoration in the mandibular or maxillary area 2. asa 1 e asa 2 3. subject is 30-85 years old 4. patients with healthy periodontal conditions (treated periodontitis, pi\<25%, bop\<25%) 5. patients that are willing to sign an informed consent and participate in a clinical study exclusion criteria: 1. absence type 1-2 post extraction sites 2. patient asa 3 or 4 3. any sites where an implant already failed sites 4. untreated periodontitis 5. allergy declared to one or more medicaments to be used during treatment 6. pregnancy (confirmed by verbal inquiry)

Keywords: osteotomy dental implant marginal bone loss implant stability osteotome implant site preparation