Kornimate/medical-research-clean huggingface dataset:
exercise and repetitive diving

Conditions: Decompression Sickness; Endothelial Dysfunction; Neutrophil Activation; Venous Gas Emboli

Summary: scuba diving frequently involves repetitive exposures over multiple days. the goal of this study was to see how exercise impacts microparticles (mps), endothelial function, and venous gas emboli (vge) over a series of dives. 16 divers in 2 groups each completed 6 dives. one group completed 3 control dives followed by 5 days rest then 3 dives preceded by exercise. the other group completed the opposite protocol. flow-mediated dilation (fmd) data and blood for mp analysis was collected before and after each dive. vge were monitored via transthoracic echocardiography 30, 60, and 90 min after surfacing. exercise before diving consisted of 60 min running outdoors including 8x4 min intervals at 90% vo2max effort.


Eligibility criteria:
inclusion criteria: * certified scuba diver * certified to dive by experienced medical evaluator * must be able to run continuously for 45 min exclusion criteria: * prior diagnosis of decompression sickness

Keywords: scuba diving exercise microparticles repetitive diving endothelial function
the effect of ketamine on aesthetics and role for antidepressant effects

Conditions: Major Depressive Disorder

Summary: the aim of this study is to assess the impact of ketamine on aesthetic perception and processing. this study assesses the role of these effects in facilitating ketamine's antidepressant properties, with a focus on anhedonia. to address this aim, 25 patients with major depressive disorder and 35 healthy controls will be assessed twice with magnetic resonance imaging, once after administration of intravenous ketamine (subanesthetic dose) and once after administration of placebo.this study has a single-center, placebo-controlled, cross-over study design. during mri, structural, resting state, and functional imaging will be performed. functional imaging will comprise aesthetic processing, reward, and sexual arousal paradigms. in addition, various neuropsychological scales assessing depressive symptoms, anhedonia, and aesthetic processing will be performed. eligibility for participation will be assessed during a screening visit, a follow up visit will end study participation.


Eligibility criteria:
inclusion criteria: * general health based on medical history and physical examination * psychiatric health based on structured clinical interview for dsm-5 (scid) for healthy controls * major depressive episode (first or recurrent) based on structured clinical interview for dsm-5 and icd-10 for patients * age 18 to 55 years * right-handedness (due to potential lateralization effects of lefthanded subjects) * willingness and competence to sign the informed consent form exclusion criteria: * current or history of neurological disease * current medical illness requiring treatment * psychiatric diagnosis for healthy individuals * psychiatric comorbidity with the exception of anxiety disorders for depressed individuals * pregnancy or current breastfeeding * current or former substance abuse * previous ketamine use in lifetime * any contraindication for mri (e.g., mr incompatible implants, etc.) including dental implants causing signal artifacts * failure to comply with the study protocol or to follow the instruction of the investigating team
effects of music therapy along with task-oriented training on patients with chronic stroke

Conditions: Hemiplegia

Summary: previous studies discussed the effects of music therapy and task oriented training on motor functions of stroke separately but no study is found in which effects of both techniques are studied. in this study, we are going to find the effects of task oriented training with or without music therapy.

stroke is a neurological condition, which can promote disability and increase the susceptibility to secondary complications along the patient's life. stroke issue incorporates motor dysfunction, cognition, daily activity and sensory weaknesses. music therapy appears to affect physiological phenomena such as blood pressure, heartbeat, respiration, and mydriasis as well as emotional aspects such as mood and feelings. task-oriented training is aimed at improving the control strategy by solving difficulties through various measures. in general, a variety of techniques, including bobath approach, roods approach, proprioceptive neuromuscular facilitation techniques, motor relearning program, functional approaches, stretching exercises, therapeutic massage, constrain induced movement therapy, range of motion exercises, myofascial release, and strengthening exercises have been in practice for recovery of the affected limb functional mobility in patients with stroke. this study will evaluate the effects of music therapy along with task oriented training on balance and functional independence in stroke patients.

Eligibility criteria:
inclusion criteria: age 40-60 years both males and females diagnosed stroke patients chronic stage (after 6 months of onset) individuals with burg balance score ≥ 20 ≤ 40 functional independence measure score up to 3 (moderate assistance) able to understand command mini mental status examination score of over 20 exclusion criteria: systematic disorder e.g. rheumatoid arthritis unstable angina coexisting physical impairments e.g. limb amputation any previous history of neurological disease other than stroke e.g. parkinson's any previous history of fractures hearing or perception deficits

Keywords: stroke, music therapy, task-oriented training, balance, functional independence
hpv vaccine in postpartum women

Conditions: HPV Infection

Summary: the purpose of this study is to determine the acceptability of hpv vaccination in postpartum women in central pennsylvania. participants will be recruited while inpatient in the postpartum unit. participants will complete a survey asking about knowledge, attitudes, and beliefs around vaccination, including hpv vaccination, as well as breastfeeding intentions. after survey completion, the participant will have the option to receive the hpv vaccine, gardasil 9, prior to discharge from the hospital. all participants will then be contacted 1- week later for the follow-up survey.

the purpose of this pilot study is to determine if postpartum women serve as a potential population to target in order to increase human papillomavirus (hpv) vaccination in central pennsylvania. despite being available for almost a decade, uptake of the hpv vaccine in the us remains below other countries, including england, scotland, and australia. in fact, in 2017, only 67% of us girls aged 13-17 had obtained even one dose of the hpv vaccine series. due to low rates of hpv vaccination in the united states and central pennsylvania, effective interventions are needed to help increase these rates. while vaccination is recommended at a younger age, it is effective among women 18-25 years old. based on clinical trial data, giving the vaccine to this age group has resulted in reduced abnormal pap test findings, referral for colposcopy, and treatment related to abnormal cervical cytology. however, the hpv vaccine is not usually discussed during prenatal care or routinely administered during pregnancy. previous studies have shown that offering other vaccines postpartum (e.g. tetanus or pertussis) has been successful. by offering the vaccine to this demographic group, the investigators could potentially discover an untapped target population to help increase rates of hpv vaccination.

Eligibility criteria:
inclusion criteria: 1. women postpartum with a live birth at penn state hershey medical center (pshmc), either vaginal or cesarean delivery. 2. women aged 18-26 (inclusive) years 3. women who are on a floor status level of care. 4. women who have completed 0 or 1 doses of the hpv vaccine study00013831 approval: 5/8/2020 page 6 of 24 (v.01/21/2019) 5. fluent in written and spoken english and other languages in which the human subjects protection office (hspo) consent short from is available (french, italian, russian, spanish, vietnamese, hindi, chinese and nepali) exclusion criteria: 1. women who have completed 2 or 3 doses of the hpv vaccine 2. hypersensitivity, including severe allergic reactions to yeast (a vaccine component), or after a previous dose of gardasil 9 or gardasil®. 3. allergic reaction to amorphous aluminum hydroxyphosphate sulfate or polysorbate 80 4. women being actively treated for cancer. 5. have a fever over 100.4 degrees fahrenheit (38.0 degrees celsius) 6. women who are at an icu level of care 7. women who are on a labor and delivery level of care 8. women receiving continuous iv magnesium.

Keywords: hpv vaccination cervical cancer postpartum
the effect of aspirin on reducing inflammation in human in vivo model of acute lung injury

Conditions: Acute Lung Injury

Summary: this is a double-blind, placebo-controled, randomized trial to investigate if aspirin pre-treatment has anti-inflammatory effects in a model of acute lung injury induced by inhaled endotoxin (lps) in healthy human volunteers.


Eligibility criteria:
inclusion criteria: * healthy subjects exclusion criteria: * age \< 18 years * pregnancy or breast feeding or woman of childbearing potential not using * adequate contraception. * participation in a clinical trial of an investigational medicinal product within 30 days * consent declined aspirin or non steroidal anti-inflammatory (nsaid) use in the past 4 weeks * history of asthma * known aspirin or nsaid hypersensitivity * history of peptic ulcer disease * platelet count \< 150 x 106/ml * aspirin resistance

Keywords: acute lung injury acute respiratory distress syndrome aspirin
extending and banding the roux-en-y gastric bypass

Conditions: Morbid Obesity

Summary: the roux-en-y gastric bypass (rygb) has proven to be an effective treatment for morbid obesity by reducing weight and comorbidities. extending the pouch may improve weightloss without the increase of complications. some patients regain weight after initially good weightloss. placing a minimizer around the pouch may prevent weight regain.

the roux-en-y gastric bypass (rygb) has proven to be an effective treatment for morbid obesity by reducing weight and comorbidities. extending the pouch may improve weightloss without the increase of complications. some patients regain weight after initially good weightloss. placing a minimizer around the pouch may prevent weight regain. a prospective randomize controlled trial. study population: alle patients undergoing rygb are eligible for the study. inclusion criteria are bmi 35-40 kg/m2 with one or more obesity related comorbidities, or bmi \> 40 kg/m2 without any comorbidities. intervention: standard rygb versus an extended pouch rygb vs a banded-extended rygb.

Eligibility criteria:
inclusion criteria: * all patients who are eligible for a primary rygb exclusion criteria: * bariatric surgery in medical history * patients with a language barrier which may affect the compliance with medical advice * patients with a disease not related to morbid obesity, such as cushing or drug related. * chronic bowel disease for example crohn's disease or colitis colitis. * renal impairment (mdrd \<30) * hepatic dysfunction (liver function twice the normal values) * pregnancy during follow-up * patients with treatment-resistant reflux symptoms.
clinical research study efficacy of a prototype oral rinse

Conditions: Dental Plaque

Summary: evaluate the efficacy of an oral rinse on dental plaque and gingival inflammation


Eligibility criteria:
inclusion criteria: 1. male or female volunteers 18-65 years of age 2. good general health 3. must sign informed consent form 4. minimum of 16 natural uncrowned teeth (excluding third molars) must be present. 5. no history of allergy to personal care consumer products, or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study. 6. dental selection criteria: gingivitis patients with a minimum of 16 gradable teeth with a minimum of 6 sites with a gi score of ≥ 3. subjects will be stratified according to gingivitis severity. average full mouth gi score should be in the range of 2.0 - 2.5. heavy plaque formers should be avoided. target a full mouth pi (quigley-hein) to be in the range of 1.5-3.0 exclusion criteria: 1. subjects unable or unwilling to sign the informed consent form. 2. medical condition which requires pre-medication prior to dental visits/procedures 3. moderate or advanced periodontal disease 4. history of allergy to iodine 5. history of thyroid disease 6. history of diabetes 7. 2 or more decayed untreated dental sites at screening. 8. other disease of the hard or soft oral tissues. 9. impaired salivary function (e.g. sjogren's syndrome or head and neck irradiation). 10. use of medications that are currently affect salivary flow. 11. use of antibiotics or antimicrobial drugs within 30 days prior to study visit #1. 12. pregnant or nursing women. 13. participation in any other clinical study within 1 week prior to enrollment into this study. 14. use of tobacco products 15. subjects who must receive dental treatment during the study dates. 16. current use of antibiotics for any purpose. 17. presence of an orthodontic appliance. 18. history of allergy to common dentifrice ingredients 19. immune compromised individuals (hiv, aids, immuno suppressive drug therapy) 20. women of childbearing potential and not on birth control (diaphragm, birth control pills or implants, iud (intrauterine device), condoms). 21. smoker
lung impedance monitoring in treatment of chronic heart failure

Conditions: Heart Failure

Summary: heart failure is a major clinical problem that is increasing in magnitude and the cost of management of heart failure is escalating. a significant part of this cost is related to unplanned acute presentation to emergency departments and hospitalisation with worsening shortness of breath due to increased fluid content in the lungs. many heart failure patients are already fitted with defibrillators to protect them from the risk of fast heart rhythms and sudden death and are followed up in both the heart failure clinics and defibrillator clinics. recently some of the defibrillators fitted have been equipped with an extra function that can detect and warn of changes in the fluid content of the lungs very early even before the patient starts to complain of any shortness of breath and before any signs of fluid overload are seen clinically. however, it is not known how to deal with these warnings if they occur very early and it is not known whether a medical intervention at his stage is beneficial to prevent progression and eventual hospital admission. in the majority of cases, early warnings of this kind are ignored or this function is disabled at implantation of the device. the current study will involve patients who have already been fitted with a device with the above capability. the investigators will use the new function to guide management of these patients and compare their outcome with similar patients who are fitted with devices without it. the investigators will attempt to manage early warnings by a predetermined increase in medications in a group of patients and compare their clinical course to a similar group in whom no action is taken.


Eligibility criteria:
inclusion criteria: * previously fitted with an icd or a crt-d device for primary or secondary prevention (for at least 34 days) with a medtronic optivol capable device * previous hospital admission for decompensated heart failure * left ventricular systolic dysfunction (ef \<50%) * currently compensated heart failure with a functional class of iii or better * all patients will be on optimal medical treatment including a beta blocker, an acei (or arb) and spironolactone unless contraindicated or not tolerated exclusion criteria: * decompensated patients who have nyha class iv or clinical signs of lung congestion at time of evaluation (these patients may be included later if/when their nyha class improves) * patients with a high optivol fluid index at time of evaluation (these patients may be included later when the optivol fluid index comes down) * patients with advanced renal failure ± dialysis (chronic kidney disease class 4 or 5 with an estimated gfr of \<30 ml/min)
reachout mental health support mobile app

Conditions: Type1diabetes

Summary: the purpose of this study is to investigate the effectiveness of participation in a 6-month peer-led mental health support program, delivered via a mobile app (reachout), to adults with type 1 diabetes compared to a wait-list control condition. participants will connect with a peer-supporter (an adult with type 1 diabetes trained in providing mental health support), and have access to the app features including a 24/7 chat room and face-to-face support delivered via virtual happy hours.

reachout is a mobile app which delivers peer-led mental health support to adults with type 1 diabetes. the mobile app has three support features: 1. one-on-one support delivered by a peer supporter peer supporters are adults with type 1 diabetes who will be trained on providing support to other adults with type 1 diabetes on the app ("the participants"). participants will be able to go through the peer supporter library, review their profiles, and choose their peer supporter. 2. group support delivered via a 24/7 chat room peer supporters and participants on the app will be able to chat 24/7 in the chat room about any topic ranging from feedback on new devices to traveling with diabetes. the chat room is monitored by healthcare professionals including a registered nurse and registered psychologist. 3. face to face support delivered via virtual happy hours virtual happy hours are educational presentations/discussions led by either a peer supporter or healthcare professional on topics related to diabetes. participants will be randomly assigned to the intervention group or the wait-list control group. the intervention group will be given access to the mobile app right away and the wait-list control group will be given access to the mobile app after six months. the intervention is 6 months long. all participants and peer supporters will go through an assessment at the start and end of the program. the assessment includes a blood draw to measure hemoglobin a1c, and questionnaires measuring diabetes distress, perceived social support, depressive symptoms, resilience, quality of life, and costs related to diabetes. there will also be questionnaires throughout the program including at 1-month and 3-months. participants and peer supporters who own a dexcom g6 continuous glucose monitor (cgm) will be asked if they would like to share their cgm data.

Eligibility criteria:
inclusion criteria: * have type 1 diabetes (t1d) * be 19 years or older * reside in one of the targeted health authorities in british columbia (fraser health, island health, northern health, and interior health authorities) * be english proficient * have an average diabetes distress (dd) subscale score ≥ 2 * have access to the internet and/or a smartphone. exclusion criteria: * participants with a pre-existing mental health condition, multiple co-morbidities, substance use challenges, and or any other condition that may prevent meaningful participation may not participate in this study.

Keywords: mental health type 1 diabetes peer support technology
ascending single dose study of rhu-pgelsolin in patients with decreased gelsolin levels

Conditions: Low Gelsolin; Trauma; Infection; Burns

Summary: this study is designed to assess the pharmacokinetics and safety of an infusion of a single dose of recombinant plasma gelsolin (rhu-pgelsolin) when given to patients admitted to the intensive care unit with documented low levels of natural gelsolin. it is believed that this drug will raise the gelsolin levels in these patients and decrease the probability that they will develop complications from their underlying disease such as organ system failure or death.

this is a randomized, double-blind, placebo-controlled, ascending single dose of rhu-pgelsolin infusion study. thirteen subjects (10 active and 3 placebo) will be dosed at 3 mg/kg and 5 subjects (3 active and 2 placebo) will be dosed at 6 mg/kg. in addition, twenty-two subjects (18 active and 4 placebo) will be dosed at 6 mg/kg per day for 3 days. the data safety monitoring committee (dsmc) and steering committee will review the preceding dose safety data, and agree the tolerability prior to the enrolment for next higher dose. blood samples will be collected during 1 hour infusion through 72 hours post dose for pk assessment after each dose.

Eligibility criteria:
inclusion criteria: * \>18 years of age * documented gelsolin level \<100 mg/ml * admission to icu * women of child-bearing age have a negative pregnancy test * multiple organ failure score \< 4 * catheter present through which blood samples can be taken * written informed consent obtained exclusion criteria: * participation in other investigational treatment protocols * patients \<18 years of age * patients who have a modified multiple organ failure score of \>=4 * patient, who in the opinion of the principal investigator, are unlikely to be in the icu for \>48 hours

Keywords: gelsolin trauma pneumonia peritonitis burn infection sepsis systemic inflammatory response syndrome
diagnostic performance of dual energy ct for the detection of gallbladder gallstones

Conditions: Gallstone

Summary: to assess diagnostic performance of dual energy ct fo gallblader gallstone detection.

detection of gallbladder gallstone using dual energy ct compare to gallblader ultrasound (gold standard). all patients who undergo dual-energy ct scans will undergo abdominal ultrasound for gallstones. performance of ct to conventionnal kev will be compare to low kev monoenergetic reconstruction, and effective z. expected duration of inclusion 3-6 months. no follow-up.

Eligibility criteria:
inclusion criteria: * patient referred to the radiology department for an abdominal ct for abdominal pain, suspicion of cholangitis, cholecystitis, migration of stones, acute pancreatitis, suspicion of perforated ulcer in the emergency setting. * non-objection of the subject to participate in the study * affiliation to a french social security scheme or beneficiary of such a scheme. exclusion criteria: * cholecystectomy * legal incapacity or limited legal capacity, legal safeguard * pregnant women * subject unlikely to cooperate in the study and/or low cooperation anticipated by the investigator * subject being in the exclusion period of another study

Keywords: abdominal and pelvic scan abdominal ultrasound
a longitudinal, observational biomarker study in participants with primary sjogren's syndrome

Conditions: Healthy; Sicca Syndrome; Sjögren's Syndrome

Summary: the main objective of the study is to characterize the gene expression in immune and epithelial cells in salivary gland biopsy samples and blood of pss (primary sjögren's syndrome) and non-pss participants including healthy volunteers.


Eligibility criteria:
key inclusion criteria: for healthy volunteers: * in good overall health as determined by the investigator for participants with sicca * subjects should present with sicca (i.e., dry eyes and dry mouth) at baseline * must be willing to undergo a minor salivary gland (labial) biopsy key exclusion criteria: * a history of any clinically significant medical condition, as determined by the investigator, that may impact study analyses * a chronic or persistent infection human immunodeficiency virus (hiv), hepatitis b, hepatitis c, and/or tuberculosis * pre-existing connective tissue disease or autoimmune disease, such as systemic lupus erythematosus (sle), rheumatoid arthritis, systemic sclerosis, or sarcoidosis * any known contraindications of sialoscintigraphy note: other protocol defined inclusion/exclusion criteria may apply