Kornimate/medical-research-clean huggingface dataset:
combination of fluoroscopy and ultrasonography guidance in sacroiliac joint injections

Conditions: Sacroiliac Joint Somatic Dysfunction; Sacroiliac Joint Pain

Summary: the primary purpose of this study is to investigate the effect of the application of sacroiliac joint injection guided by combination of ultrasonography and fluoroscopy on the duration of the procedure and the amount of radiation exposed during the procedure, compared to the application of only fluoroscopy-guided technique. secondary objectives are to evaluate the effectiveness of the treatment with both methods and to record the adverse events that may be encountered during the procedure.

the study was designed as prospective, randomized, controlled trial. the patients who meet the eligibility requirements will be randomized into two groups in a 1:1 ratio to fluoroscopy and ultrasound+fluoroscopy. processing time will be recorded during injection. "fluoroscopy time" (sec) and "kerma-area product" (μgy) automatically measured by the fluoroscopy device will be used to evaluate the radiation exposure. pre-procedural visual analogue scale (vas) scores and oswestry disability index (odi) values were noted all the patients.

Eligibility criteria:
inclusion criteria: * low back and/or gluteal pain and/or groin pain without radicular extension below the l4 level for more than 3 months * pain score greater than 3 according to nrs * unresponsiveness to conservative treatment (such as exercise, nsaid) * at least 3 of the five sacroiliac provocation tests (faber (patrick), thigh thrust, gaenslen, sacroiliac compression, and sacroiliac distraction tests) are positive exclusion criteria: refusing to participate in the study * pregnancy * infective sacroiliitis * malignancy * osteoporosis * mechanical lumbosacral pathologies (spondylolisthesis, scoliosis, stenosis, etc.) * neurological finding in the lower extremity * pain spreading below the knee * history of spinal surgery * history of allergy to drugs to be injected (local anesthetic, contrast material, steroid allergy)

Keywords: sacroiliac joint pain sacroiliac joint injection ultrasonography guided injection flouroscopy guided injection
this is an open-label, multi-center, extension study designed to evaluate the longer term safety, tolerability and effectiveness of lurasidone, flexibly dosed, adjunctive to lithium or divalproex for the treatment of subjects with bipolar i disorder who have participated in study d1050296

Conditions: Bipolar I Disorder

Summary: this is an open-label, multi-center,12 week extension study designed to evaluate the longer term safety, tolerability and effectiveness of lurasidone, flexibly dosed, adjunctive to lithium or divalproex for the treatment of subjects with bipolar i disorder, who have either completed the core study d1050296 or experienced a protocol defined recurrence of a mood event in the double-blind phase of the core study d1050296

to evaluate the longer term safety of lurasidone (20, 40, 60 or 80 mg/day) in subjects with bipolar i disorder. subjects will be initially treated with open-label lurasidone 40 mg/day (day 1). dose adjustment of study drug (20, 40, 60 or 80 mg /day) should occur at the regularly scheduled visits and in increments/decrements of 1 dose level.

Eligibility criteria:
inclusion criteria: * subject has agreed to participate by providing written informed consent. * subject has completed the 28 week double-blind phase of study d1050296 and all required assessments on the final study visit (week 28, visit 28); or * subject has experienced a protocol-defined recurrence of any mood event during the double blind phase of study d1050296 and has completed all required assessments on the final study visit; or * subject had at least entered the open-label phase of study d1050296 when the sponsor stopped the study and has completed all required assessments on the final study visit. * subject is judged by the investigator to be suitable for participation in a 12 week clinical trial involving open-label lurasidone treatment and is able to comply with the protocol in the opinion of the investigator. exclusion criteria: * subject is considered by the investigator to be at imminent risk of suicide or injury to self, others, or property. * subject answers "yes" to "suicidal ideation" item 4 (active suicidal ideation with some intent to act, without specific plan) or item 5 (active suicidal ideation with specific plan and intent) on the columbia suicide severity rating scale (c-ssrs) at the extension baseline visit (final study visit in study d1050296).

Keywords: lurasidone latuda bipolar disorder
feasibility of home-based measurement of walking capacity using global positioning system in peripheral artery disease

Conditions: Peripheral Artery Disease

Summary: the purpose of this study is to assess the feasibility of home-based measurement of walking capacity in peripheral arterial disease (pad) patients, uing the global positioning system (gps). this study should state if the gps technique could be used in clinical routine in order to assess walking capacity in pad patients. patients will be assessed a first time (test 1) and six months later (test 2).

the measurement of walking capacity in pad patients is an important step in the management of such patients. the gold standard method to assess this walking capacity is the measurement of the maximal walking distance on a treadmill. however, treadmill measurement are not readily accessible and the relationship with free-living walking capacity is, although not well known, weak. a novel approach was developed using a global positioning system in order to assess community-based walking capacity. this method showed interesting results, validating the technique, but was limited to one laboratory and to the place where the measurements were performed. the next step is therefore to assess the feasibility of home-based measurement of walking capacity using the gps technique, through a multicenter study regrouping university hospitals, independent vascular specialists (angiologists) and private clinic(s).

Eligibility criteria:
inclusion criteria: * abi \< 0.90 or patients with vascular history (surgery, endovascular treatment) and having vascular type claudication * older than 18 years * vascular-type claudication (defined by the leriche classification and the edimbourg questionnaire criterion) * informed consent of the patient non-inclusion criteria: * no informed consent of the patient * exercise (walking) limitation other than vascular explained limitation * critical limb ischemia (leriche stage 3 or 4) * major cardiovascular events in the last 3 months * pregnant woman * patient unable to understand the protocol of the study exclusion criteria: * withdrawal of the informed consent of the patient following the inclusion period * emergence of a non-inclusion criteria during the inclusion period * patient with a gps maximal walking distance \> 2000 meters following the first evaluation (can not be considered as having a major walking limitation)

Keywords: claudication artery ambulatory technique gps
acupuncture for overactive bladder in adults

Conditions: Overactive Bladder

Summary: the purpose of this study is to assess the effectiveness and safety of acupuncture for treating overactive bladder in adults.

this randomized, controlled trial is aimed to assess the effectiveness and safety of acupuncture in the treatment of overactive bladder (oab) in adults. eligible participants will be randomly allocated to acupuncture or sham acupuncture. to minimize the evaluation bias, the outcome assessors and statisticians will be masked to treatment allocation besides participants.

Eligibility criteria:
inclusion criteria: * present symptoms of urinary frequency and urgency for more than 3 months. * with a total score of more than 3 points on the overactive bladder symptom score (oabss) and a score of more than 2 points on question 3 of oabss. exclusion criteria: * with other lower urinary tract disorders (e.g. urinary tract infection, bladder outlet obstruction, neurogenic bladder, interstitial cystitis, etc.) * with previous pelvic floor surgery or a post-void residual urine volume more than 100 ml. * with neurological disease or psychiatric illness. * taking medications affecting lower urinary tract function. * with contraindications to acupuncture. * pregnant women.

Keywords: overactive bladder acupuncture
chronic obstructive pulmonary disease (copd)-related healthcare utilization and costs after discharge from a hospitalization or emergency department visit on a regimen of fluticasone propionate-salmeterol combination versus other maintenance therapies

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this was a retrospective cross-sectional database study using administrative data (study period: 1/1/2003 through 7/31/2008). managed care enrollees (aged \>40 years) having at least one hospitalization with primary or secondary diagnosis of copd (icd code 491.xx, 492.xx and 496.xx) or at least one emergency room (er) visit with primary diagnosis of copd (index event) during the study period was the target population. all subjects were required to have one year of pre-index period baseline data. copd events of interest were er, hospital and physician visits followed by oral corticosteroids (ocs) or antibiotics (ab) within 7 days. other censoring events were treatment switch; loss of enrollment; \>60-day gap between medication fills; or end of study period. this study is a non descriptive hypothesis testing study. key study hypotheses are listed below. specifically the study hypotheses for the primary outcome being tested were: ho: there is no difference in risk of copd-related hospitalization between fsc and omt ha: there is a difference in risk of copd-related hospitalization between fsc and omt hypothesis for the key secondary outcome of copd-related costs that was tested was: ho: there is no difference in copd-related costs between fsc and omt ha: there is a difference in copd-related costs between fsc and omt


Eligibility criteria:
inclusion criteria: * at least one hospitalization with a primary or secondary diagnosis of copd or at least one er visit with a primary diagnosis of copd * initiatiation (prescription) of fsc or non-fsc (i.e. tio, ics, laba, ipr) during peri-index period * at least 40 years of age * continuous eligibility in the pre-index, peri-index, and follow-up periods exclusion criteria * presence of exclusionary comorbid conditions during pre-index, peri-index, and follow-up periods: respiratory cancer, cystic fibrosis, fibrosis due to tb, and bronchiectasis, pneumonociosis, pulmonary fibrosis, pulmonary tuberculosis, sarcoidosis * controller medication use during peri-index period * copd-related hospitalization, er visit, or physician visit plus ocs/abx within 3 days of visit during the peri-index period
effects of different myofascial release techniques on iliotibial band tightness

Conditions: Fascia Lata

Summary: the aim of the study is to investigate the effects of foam roller and instrument assisted soft tissue mobilization on pain, functionality and performance in athletes with iliotibial band tightness

subject in this study, the effects of foam roller myofascial massage and instrument assisted soft tissue mobilization (iastm) (massage performed by applying light pressure to the skin with a tool) on pain, functionality and performance will be investigated in athletes with iliotibial band tightness. there are studies on both iastm and foam roller massage in the literature and they are popular applications recently. however, within our knowledge, when we look at the turkish and english literature, no study has been found that compares these two therapeutic massages in terms of pain, functionality and performance. purpose poor posture, facial traumas and stiffness cause tension in the fascia of that region and result in pain. this disrupts the complementary mechanism of the fascia, causing the structures attached to the fascia to be out of the normal sequence. facial problems have an important place in athletes. facial problems cause pain in the athlete, reducing the athlete's sportive performance and negatively affecting their functionality. in order to prevent these limitations and accelerate the recovery, the rehabilitation process is started after the surgery. various exercises and myofascial massages are routinely applied to problems seen in athletes. myofascial massage techniques can be used in athletes' problems for many positive reasons such as effective in a short time, rapid results, high success rate, risk-free and painless if experts do. thanks to the findings to be obtained from our study, it is aimed to contribute to the literature with objective, evidence-based results in this field.

Eligibility criteria:
inclusion criteria: * the leg inclinations of the athletes evaluated with the ober test will be measured with an inclinometer and the athletes below 25 degrees will be included in the study. * age between 18 and 30 years * agree to participate in the study, exclusion criteria: • not having surgery

Keywords: fascia lata fascia massage musculoskeletal manipulations
magnetic resonance imaging-based radiation therapy and cisplatin in patients with stage i, stage ii, stage iii, or stage iv cervical cancer

Conditions: Cervical Cancer

Summary: rationale: computer systems that allow doctors to create a 3 dimensional (3-d) picture of the tumor may help in planning radiation therapy and may result in more tumor cells being killed. specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. drugs, such as cisplatin, may make tumor cells more sensitive to radiation therapy.

purpose: this clinical trial is studying magnetic resonance imaging-based radiation therapy and cisplatin in treating patients with stage i, stage ii, stage iii, or stage iv cervical cancer.detailed descriptionprimary objectives: i. to evaluate the feasibility of using mri based treatment planning for intracavitary brachytherapy treatment planning. secondary objectives: i. to evaluate the incidence of early toxicities, specifically genitourinary and gastrointestinal. ii. to evaluate the incidence of late toxicities, specifically genitourinary and gastrointestinal. iii. to evaluate local, regional, and distant recurrence rates. iv. to evaluate disease-free and overall survival rates. outline: patients undergo external beam radiotherapy (3-dimensional conformal or intensity-modulated) and 4-6 insertions of mri-guided intracavitary brachytherapy over 8 weeks. patients also receive cisplatin iv over 30-60 minutes for 5-6 weeks during radiotherapy. after completion of study treatment, patients are followed at 6 weeks, every 4 months for 2 years, and then every 6 months for 3 years.

Eligibility criteria:
inclusion criteria: * subjects must have histologically confirmed squamous cell, adenosquamous or adenocarcinoma of the cervix * subjects must have non-metastatic figo stage ia-iva cervical cancer * claustrophobic subjects must agree to be sedated during mri procedures * ecog performance status of 0-2 exclusion criteria: * subjects with an inability to tolerate mr imaging * subjects who have had prior surgery for treatment of disease other than exploratory laparotomy or biopsy * study subjects who have contraindication to mri scanning such as but not limited to subjects with pacemakers, metal fragments in the eye or certain metallic implants * women of childbearing potential who have a positive result on screening serum pregnancy test
human amniotic membrane to decrease post operative atrial fibrillation

Conditions: Atrial Fibrillation

Summary: this study will evaluate the application of ham at the time of cardiac surgery to decrease inflammation and the subsequent substrate to reduce incidence of post-operative atrial fibrillation. patients will randomized 1:1 to receive either ham application or standard of care.


Eligibility criteria:
inclusion criteria: * patients undergoing primary elective cabg at the university of utah hospital * ability to provided informed consent and follow-up with protocol procedures exclusion criteria: * patients in af at the time of surgery * prior history of sternotomy * prior history of pericarditis * currently on aggressive antiarrhythmic therapy (does not include beta blockers) * patients with an implantable cardiac device (pacemaker, icd, crt-d) * ejection fraction \<45%
epidemiology of depression and heart failure in aging

Conditions: Cardiovascular Diseases; Heart Diseases; Heart Failure; Heart Failure, Congestive; Depression; Coronary Disease

Summary: to understand how depression leads to congestive heart failure (chf) in older adults.

background: depression is known to be associated with an increased risk of coronary heart disease (chd), and with adverse outcomes among older adults with chd. recent evidence suggests that depression is also associated with an increased risk of congestive heart failure, and with adverse outcomes among older adults with congestive heart failure. however, the mechanisms by which depression leads to congestive heart failure are not known design narrative: to determine the mechanisms of association between depression and chf, the investigators will use an existing cohort of 1024 older adults (mean age 67) with chd (including 680 with no heart failure and 344 with clinical or subclinical heart failure) who were recruited between september 2000 and december 2002 for "the heart and soul study." the heart and soul study was originally designed to understand the mechanism of association between depression and chd. since patients with chd are at high risk for chf, this well-characterized cohort will provide a unique opportunity to examine the relation between depression and chf. at baseline, participants completed a depression interview (diagnostic interview schedule); full exercise treadmill testing with stress echocardiography; 24-hour holter monitoring for heart rate variability; 24-hour urine collection for cortisol and norepinephrine; venous blood measurements for lipids, platelet reactivity, and c-reactive protein; and an extensive questionnaire. participants have been followed annually by telephone. the investigators will invite all participants to return for a 5-year examination, and will follow them for an additional 3 years thereafter, to determine (a) the independent association between baseline depression and chf, and (b) the extent to which 5-vear changes in biological and behavioral factors associated with depression explain the relation between depression and chf. by identifying the mechanisms that explain the relation between depression and chf, this study will enable them to target specific areas for improving the treatment of these patients.

Eligibility criteria:
no eligibility criteria
a study of glaucoma therapy to treat open-angle glaucoma or ocular hypertension

Conditions: Open-angle Glaucoma; Ocular Hypertension

Summary: the purpose of the study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension


Eligibility criteria:
inclusion criteria: * adult patients of either sex of any race diagnosed with open-angle glaucoma (with or without pseudoexfoliation or pigment dispersion component) or ocular hypertension. * other protocol-defined inclusion criteria may apply. exclusion criteria: * under age 18. * other protocol-defined exclusion criteria may apply.

Keywords: open-angle glaucoma ocular hypertension
muscular changes in the first 12 weeks after stroke.

Conditions: Stroke

Summary: the investigators will use 3d freehand ultrasound to investigate changes in muscle morphology of the paretic m. rectus femoris and m. gastrocnemius medialis during the first 3 months after stroke. additionally, 2d ultrasound and surface emg will be synchronized to examine muscle activation and morphological changes resulting from this activation. clinical tests will be conducted on the same test occasions to objectify lower limb impairment and gait recovery. as such, the investigators will explore the relationship between the muscle specific changes and functional recovery.

during this longitudinal study, patients who suffer their first-ever stroke will be included within the first week after their stroke (if the inclusion criteria are met). thereafter, each participant will be assessed at four pre-determined time-points: week 1, 5, 8 and 12 after stroke. on each of the four time-points, the investigators will assess muscle specific parameters of the affected m. rectus femoris (rf) and m. gastrocnemius medialis (gm), together with clinical tests to assess lower limb impairment (fugl-meyer assessment for the lower limb and the tardieu scale) and gait parameters (10-meter walk test). specifically, muscle specific parameters will be investigated using 3d freehand ultrasound (3dfus) and combined dynamic 2d us and surface electromyography (semg). such assessments will help us characterize the electromechanical properties of these muscles, their time-related trajectories and the relationship with the recovery of gait and lower limb function after stroke. at the end of the investigation period, after 3 months, patients who can walk independently will perform a 3d gait analysis. as such, the relationship between changes in muscle specific parameters and the eventual gait quality at the end of the investigation period will be investigated.

Eligibility criteria:
inclusion criteria: * adults (≥ 18 years old) * diagnosed with a first-ever stroke (as defined by who) * stroke onset ≤ 1 week (± 3 days) * able to provide written or verbal informed consent at admission * presence of gait problems as a consequence of the stroke (fac≤4) exclusion criteria: * presence of other neurological or orthopedic problems present prior to, or not caused as a direct consequence of, the stroke leading to impaired gait. * modified ranking scale pre-stroke \> 1/6, meaning presence of slight disability before the stroke. * presence of severe comorbidities (e.g. osteoporosis, cardiovascular instability or chronic obstructive pulmonary disease). * cerebellar or bilateral stroke. * presence of severe deficits in communication, memory or understanding precluding informed consent.

Keywords: muscular changes m. rectus femoris m. gastrocnemius medials lower limb impairment gait recovery subacute phase 3dfus semg dynamic ultrasound