Kornimate/medical-research-clean huggingface dataset:
fascial distortion model with and without neck isometrics in patients with cervical spine overload

Conditions: Neck Pain

Summary: cervical spine pain is the one the most common musculoskeletal disorder and spinal overload is one of the major causes. forward tilting of every inch of head increases load on the cervical spine and is referred as cervical spine overload. persistent overloading and overburdening results in radiation of pain, weakness of muscles and limitation in joint range. psychological factors are also play role in acute, sub-acute or chronic neck pain. treatment commonly used for this pain is nsaid, physiotherapy interventions (mobilisation, manipulation, tens, ultrasound, stretching, isometrics and fdm) and awareness about posture. fdm was established in 1991 by stephan typaldos and it recommends that musculoskeletal ailments are due to disruption in fascia. there are 6 diverse proposed facial distortions and diagnosis in this model i.e., trigger band, herniated trigger band, folding distortion, continuum distortion, tectonic fixation and cylinder distortion. main purpose of this randomised clinical trial will be to find out the effects of fascial distortion model with and without neck isometrics in patients with cervical spine overload. patients will be recruited into study by consecutive sampling technique and after that patients will be allocated to the groups by random sampling assignment. nprs, ndi and goniometer will be used as data measuring tool. treatment will be given to 2 groups. one group will get treatment of only fdm and other group will get treatment of fdm and neck isometrics as well. treatment will be given two times a week for 4weeks and duration of the session will be of 30 minutes. after collecting data from defined study setting, data will be entered and analyzed by using statistical package for the social sciences (spss) for windows software, version 25. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be use within a group or between two groups.


Eligibility criteria:
inclusion criteria: 1. inclusion criteria: * trigger band pain pattern * age limit 20 to 30 years. * male and female * pain in the cervical spine * limited cervical rom * uneasiness while working in a sitting posture for 4 hours but no abnormal neurological findings exclusion criteria: * progressive degeneration of spine (spondylosis) * previous cervical spine injuries * congenital and developed spine deformities (scoliosis)
the effect of potato fries processing on food intake, satiety and blood glucose

Conditions: Obesity; Overweight; Diabetes; Metabolic Syndrome

Summary: potato is one of the world's most popular foods and is widely accepted as a staple food. the objective of this study is to determine the effect of altering commercial blanching and cooling times during manufacture of frozen fries produced by the on blood glucose, satiety and appetite. it hypothesized that the processing regime predetermines the physiologic responses to ingested product and therefore it is possible to produce healthier product lines of potato fries.


Eligibility criteria:
inclusion criteria: * healthy men with a body mass index (kg/m2) of 20-24.9 exclusion criteria: * smocking, medication, breakfast skipping, restrained eating
multiple coolsculpting treatment study

Conditions: Body Fat Disorder

Summary: to evaluate the safety of same-day coolsculpting treatments and to assess the impact on serum lipids and liver-related tests.

the study will evaluate the safety of multiple same-day coolsculpting treatments and will assess any impact on serum lips or liver-related analytes,

Eligibility criteria:
inclusion criteria * male or female subjects \> 18 years of age. * subject who has been assessed to receive multiple coolsculpting treatments on the abdomen and flanks, defined as follows: 1. lower abdomen - one 60 minute cycle with coolmax, 2. right and left flank - one 60 minute cycle per flank, with coolcurve+ or coolcore, simultaneously. * subject has not had weight change exceeding 10 pounds in the preceding month. * subject with body mass index (bmi) up to 30. bmi is defined as weight in pounds multiplied by 703 divided by the square of the height in inches. * subject agrees to not making any major changes in their diet or lifestyle during the course of the study. * subject has read and signed a written informed consent form. exclusion criteria * subject has had an invasive (e.g., liposuction, mesotherapy, abdominoplasty) or non-invasive fat reduction and/or body contouring procedure in the area of intended treatment within the past 6 months. * subject needs to administer, or has a known history of subcutaneous injections into the area of intended treatment (e.g., heparin, insulin) within the past month. * subject has a known history of cryoglobulinemia, cold urticaria, or paroxysmal cold hemoglobinuria. * subject has a history of hernia in the area(s) to be treated. * subject is pregnant or intending to become pregnant during the study period (in the next 4 months). * subject is lactating or has been lactating during the past 3 months. * subject is unable or unwilling to comply with the study requirements, such as blood draw. * subject is currently enrolled in a clinical study of any other unapproved investigational drug or device. * subject has a history of lipodosis or other confounding metabolic diseases. * subject is taking or has taken medication within the past 3 months which may affect the metabolic function. * patient has a history of diabetes. * any other condition or laboratory value that would, in the professional opinion of the investigator, potentially affect the subject's response or the integrity of the data or would pose an unacceptable risk to the subject.

Keywords: lipolysis cryolipolysis fat reduction
covid-19: sars-cov-2 detection in saliva, oropharyngeal and nasopharyngeal specimens

Conditions: SARS-CoV Infection; Covid19; Coronavirus

Summary: the aim of this study is to compare the sars-cov-2 detection rate using either a saliva, oropharyngeal swabs or nasopharyngeal swab method for specimen collection.

the reference test to evaluate patients with suspected respiratory infection caused by virus is a real-time reverse transcription-polymerase chain reaction (rt-pcr) from a nasopharyngeal swab (nps). however, other specimen collection methods like oropharyngeal swabs (ops) and a saliva specimen collection have also been accepted by the centers for disease control and prevention for sars-cov-2 testing during the current coronavirus disease 19 (covid-19) pandemic. it is unclear how much the sars-cov-2 detection rate differs when using different sampling methods and the aim of this study is to compare the expected covid-19 detection rate using saliva, oropharyngeal swabs or nasopharyngeal swab in a public setting. we, therefore, aim to investigate the detection rate of sars-cov-2 in saliva, oropharyngeal swab, and nasopharyngeal swab specimen samples collected in symptomatic and non-symptomatic individuals tested for covid-19 in a public test center during the covid-19 pandemic. individuals referred for outpatient covid-19 testing center will be invited to participate in a prospective clinical study. they will have saliva, ops, and nps specimen collection performed at the same time and analyzed separately for sars-cov-2. the rate for sars-cov-2 detection in saliva, ops, and nps will be compared using a logistic regression mixed-effect analysis. a sample size calculation estimated that a sample of 18,000 participants would be needed for the trial with 80% power at a significance level of 5%.

Eligibility criteria:
inclusion criteria: * volunteers, who are attending the covid-19 test facilities to obtain a rt-pcr test. * oral and written informed consent to participate before entering the study. exclusion criteria: * failure to understand and provide informed consent. * neck breathers (tracheostomy/laryngectomy patients) or other nasopharyngeal or oropharyngeal anomalies that do not allow for sampling using swabs.
comparative effectiveness of treatments to prevent dental caries

Conditions: Dental Caries

Summary: dental caries (tooth decay) is the most prevalent childhood disease in the world. multiple interventions are available to treat and prevent caries. the aim of the proposed study is to compare the benefit of silver diamine fluoride (sdf) and fluoride varnish versus fluoride varnish and glass ionomer sealants. this study is a five-year, cluster randomized, pragmatic controlled trial conducted in public elementary schools in new hampshire.

dental caries is the most prevalent childhood disease in the world and can lead to infection, pain, reduced quality of life, and negative educational outcomes. multiple prevention agents are available to arrest and prevent dental caries, however little is known of the comparative effectiveness of combined treatments in pragmatic settings. the aim of the presented study is to compare the benefit of silver diamine fluoride and fluoride varnish versus fluoride varnish and glass ionomer therapeutic sealants in the arrest and prevention of dental caries. this is a longitudinal, pragmatic, cluster randomized, single-blind, non-inferiority trial to be conducted in low-income children enrolled in public elementary schools in new hampshire from 2017-2023. the primary objective is to assess the non-inferiority of alternative agents in the arrest and prevention of dental caries. caries arrest will be evaluated after two years, and caries prevention will be assessed at the completion of the study. data analysis will follow intent to treat, and statistical analyses will be conducted using a two-sided significance level of 0.05. notably, the standard of care for dental caries is office-based surgery, which presents multiple barriers to care including cost, fear, and geographic isolation. the simplicity and affordability of silver diamine fluoride may be a viable alternative for the arrest and prevention of dental caries in high-risk children.

Eligibility criteria:
inclusion criteria: * any primary school with a previously employed caries prevention program operating in rural areas, with official title 1 status, and located in a health professional shortage area. within participating schools, all children are eligible to participate in the study. those with informed consent and assent will receive care. exclusion criteria: * children without informed consent or those with consent but without assent.

Keywords: dental caries caries arrest caries prevention silver diamine fluoride sealants interim therapeutic restorations
the correlation between covid-19 and dysphagia in adults with swallowing disorders

Conditions: COVID-19; Dysphagia

Summary: this study aims to investigate the correlation between covid-19 and dysphagia in adults. the population of the study consisted of those who applied to bezmialem university, department of otorhinolaryngology, dysphagia outpatient clinic with the complaint of dysphagia. patients older than 18 years of age, suffering from dysphagia and not having mental retardation were included in the study. patients who did not have swallowing difficulties and refused to participate in the study were excluded.

coronavirus disease 2019 (covid-19) is characterized by involvement in multiple tissues and organs throughout the body. conditions related to covid-19 itself or its treatment are known to be associated with swallowing function. our study aimed to investigate the correlation between covid-19 and dysphagia in adults who applied to our dysphagia outpatient clinic. patients over the age of 18, who applied to the dysphagia outpatient clinic were included in our study. patients' demographic and covid-19 information were recorded. swallowing impairment of the patients was evaluated with the fiberoptic endoscopic swallowing study (fees). fees was scored with the penetration-aspiration scale (pas). eating assessment tool-10 (eat-10) questionnaire was used to examine how the quality of life of the patients was affected by swallowing difficulties. oral motor dysfunction (omd) evaluation was performed by the clinician.

Eligibility criteria:
inclusion criteria: * older than 18 years of age * suffering from dysphagia * not having mental retardation exclusion criteria: * patients who did not have swallowing difficulties * refused to participate in the study

Keywords: covid-19 dysphagia flexible endoscopic swallowing study oral motor dysfunction
an integrated consent model study to compare two standard of care schedules for monitoring cardiac function in patients receiving trastuzumab for early stage breast cancer

Conditions: Breast Cancer

Summary: several large adjuvant trastuzumab trials have demonstrated improved overall survival, in participants with early stage breast cancer, with a 33% decrease in risk of death. however, retrospective analyses of participant outcomes in these trials have demonstrated increased risk of cardiotoxicity (i.e damage to the heart) in a small number of patients (4-8%). at this time, investigators are unable to predict which participants are at increased risk of cardiac-related treatment complications. currently all patients receive regular cardiac imaging throughout their one year of trastuzumab treatment. at this time, the optimal monitoring schedule for trastuzumab-related cardiotoxicity remains unknown, and several published consensus guidelines are currently in use as "standard of care.


Eligibility criteria:
inclusion criteria: * histologically confirmed early stage her2-positive breast cancer * planned trastuzumab therapy for early stage breast cancer * ≥18 years of age * able to provide verbal consent * normal lvef (\>53%) before trastuzumab therapy exclusion criteria: • contraindication to transthoracic echocardiography or muga

Keywords: cardiac toxicities
evaluation of clinical and genetic modifiers of long-term survival in heart failure

Conditions: Heart Failure

Summary: the purpose of this study is to evaluate the beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade in patients with chronic heart failure.


Eligibility criteria:
inclusion criteria: 1. 18 years of age or older; 2. patients are required to have chronic heart failure (nyha ii-iv) with a left ventricular ejection fraction lower than 40%; 3. patients are voluntary and signed informed consent. exclusion criteria: 1. pregnant women or plan to; 2. participate in any drug clinical trials within 3 months; 3. serious neurological disease (alzheimer's disease, parkinson syndrome, progressive lower limbs or deaf patients); 4. previous history of cancer or tumor, or pathological examination confirmed precancerous lesions; 5. patients refused to comply with the requirements of this study to complete the research work; 6. according to the researchers, patients can not complete the study or not to comply with the requirements of this study (because of the reasons for the management or other reasons).
brain olfactory pathways in prader-willi syndrome

Conditions: Prader-Willi Syndrome

Summary: studying the cerebral activity of children with prader-willi syndrom (pws) when the study propose to them nasal activations.

the present study propose to implement fmri and olfactory tests to describe olfactory brain activation and olfactory skills in early ot-exposed and non-exposed children with pws. this study is part of a wider project in collaboration with the team of s. steculorum at the max planck institute in germany who assess the architectural and molecular characterization of the olfactory system development in a mice model of pws and the role of early ot treatment. moreover, the study will take advantage of the mri to document the long-term brain connectivity of early ot-exposed and non-exposed children.

Eligibility criteria:
inclusion criteria: * child with a genetically confirmed diagnosis of pws and for whom the genetic subtype (deletion or non deletion) has been identified * child aged between 5 and 7 years * child with a planned hospitalization at the toulouse reference center for pws exclusion criteria: * presence of a contraindication to mri * allergy to any of the fragrances used in the olfactory test * presence of an ent infection such as rhinitis or sinusitis on the day of inclusion * reported anosmia * administrative problems.

Keywords: cerebral activity olfactory activation
efficacy and safety of electroacupuncture and acupuncture in postmenopausal women with overactive bladder

Conditions: Overactive Bladder; Menopause

Summary: the purpose of this study is to verify the efficacy and safety of electroacupuncture treatment of postmenopausal women with overactive bladder (oab).

the investigators targeted the patients of menopausal women with oab. after treatment in 2 groups - electroacupuncture treatment and acupuncture treatment - the investigators will compare the improvement of the urinary symptoms and the quality of life, and further the best treatment method. in addition, the investigators are going to evaluate the safety of abnormal reaction during the treatment.

Eligibility criteria:
inclusion criteria: 1. women over 40 years of age without the possibility of pregnancy 2. have a history of amenorrhea for at least 1 year and have no previous history of hormone replacement therapy for the last 6 months 3. with symptoms of urinary frequency and urgency lasting more than three months 4. who fit the diagnostic criteria for oab, with a total score more than three points in korean version overactive bladder symptom score (oabss) 5. who have average urinary frequency of more than eight times per day and urgency which is defined as urgency rating scale (urs) on bladder diary is more than two points and/or uui on 3-day bladder diary during one week screening period 6. who agree to this clinical study after sufficient explanation exclusion criteria: 1. diag¬nosed with uti by urine examination 2. with stress urinary incontinence without symptoms of oab 3. with suspected of having voiding dys¬function induced by neurological damage 4. with a medical history of cystocele, uterine pro¬lapse or similar 5. with a medical history of obstructive uropathy such as urinary stones and urinary tumors 6. with a surgical history of urethra or bladder 7. with a medical history of malignant tumors of urinary tract 8. with a medical history of neurologic disease or psychi¬atric illness 9. have an artificial cardiac pacemaker or implantable cardioverter defibrillator in the chest 10. have experienced a hypersensitivity reaction after an acupuncture treatment, or show any other contraindications; 11. who participated in another clinical trial within the past three months 12. who have taken therapeutic drugs that may affect blad¬der function within one month of the start of this study 13. with inadequate literacy to complete study documents

Keywords: overactive bladder menopause postmenopausal overactive bladder electroacupuncture
platelet rich plasma, complex decongestive physiotherapy and low level laser in treatment of lower extremity lymphoedema

Conditions: Lower Extremity Lymphedema

Summary: at the end of the study, comparative information about the effects of prp, complex decongestive physiotherapy and low level laser on edema volume, range of motion, muscle strength, functional capacity and quality of life will be obtained in the treatment of patients with lower limb lymphedema. since there is no study about this field in the literature, this study will provide new and valuable contributions about treatment of lower extremity lymphedema for the researchers and clinicians.


Eligibility criteria:
inclusion criteria: * having lower extremity lymphedema * to be older than 18 ages. exclusion criteria: * having received radiotherapy treatment in the last 6 months, * having received physiotherapy treatment in the last 6 months, * general health status is not eligible for treatment

Keywords: lower extremity lymphedema physiotherapy complex decongestive physiotherapy low level laser platelet rich plasma
evaluation of oncoxin-viusid® in cervical cancer and endometrial adenocarcinoma.

Conditions: Cervical Carcinoma Stage II; Cervical Carcinoma Stage III; Cervical Carcinoma Stage IV; Endometrial Adenocarcinoma Stage II; Endometrial Adenocarcinoma Stage III; Endometrial Adenocarcinoma Stage IV

Summary: the purpose of this study is to evaluate the efficacy of oral solution oncoxin-viusid in the reduction of acute toxicity of radiotherapy (rtp) and chemotherapy (qtp) in patients with histological diagnosis of cervical cancer and endometrial adenocarcinoma. this is a phase ii, prospective, randomized and double blind clinical trial, which will include 66 patients assigned to 2 treatment arms: 33 patients will receive conventional treatment, plus a placebo of the nutritional supplement and another 33 patients will receive along with the conventional treatment the oncoxin-viusid nutritional supplement produced by the catalysis laboratories of spain. patients will receive oral treatment throughout the onco-specific treatment and up to 3 weeks after completion.

patients will be evaluated clinically and hematological at the beginning of the treatment, before each cycle of treatment with qtp / rtp, at month, two and three months after the end of the treatment with follow-up every three months for 1 year. the self-perceived quality of life related to health will be assessed by means of the eortc questionnaires (qlq-c30 and the specific questionnaire qlq-cx24) at the beginning and a year after completing the treatment. the toxicity to the research product will be described according to common criteria of terminology for the report of adverse events (ctcae version 4) and the tolerance to onco-specific treatment. it is expected that with the joint administration of the research product, the patients will have a better tolerance to the treatment of qtp / rtp with a decrease of the interruptions by toxicity in 25% and will preserve a better quality of life.

Eligibility criteria:
inclusion criteria: * patients with histological confirmation of cervical cancer and adenocarcinoma of the endometrium that are treated with chemotherapy and ionizing radiation. * patient with age equal to or greater than 18 years and up to 80 years. * patients who do not present decompensated concurrent diseases at the time of diagnosis that prevent or contraindicate the application of treatment with chemo-radiotherapy. * informed consent to participate in the investigation. * patients with an ecog \<or equal to 3. exclusion criteria: * patients with a history of renal failure that contraindicates the administration of cisplatin. * concomitant diseases unbalanced at the time of diagnosis or during the application of treatment. * patients with an ecog\> 3. * pregnant or lactating women. * patients who are receiving another research product. * patients who do not show consent to participate in the study.

Keywords: cervical carcinoma endometrial adenocarcinoma oncoxin-viusid nutritional supplement antioxidant