Kornimate/medical-research-clean huggingface dataset:
abf tourette's disorder post marketing surveillance study

Conditions: Tourette's Disorder

Summary: this is a post-marketing surveillance study of abilify® tablets in accordance with korean regulations on new drug re-examination (i.e. new drug re-examination standards: kfda notification no. 2010-94 dated 27 december 2010).

this study will be conducted in a prospective, single-arm, multi-center format. as this study is observational in nature, the patient's follow-up is not prescriptive in nature and must be left up to the judgment of the physician (investigator), within the period of observation set forth in the protocol.

Eligibility criteria:
inclusion criteria: * pediatric patients 6 to 18 years of age with tourette's disorder * patients who are prescribed abilify® treatment as per investigator's medical judgment. * patients who gave written authorization to use their personal and health data * patients starting abilify® treatment after agreement is in place exclusion criteria: * patients with known hypersensitivity to aripiprazole or any excipients of abilify® * patients who have been treated with abilify® * patients with rare hereditary problems of galactose intolerance, the lapp lactase deficiency, or glucose-galactose malabsorption * patients with score 0(not assessed) or 1(normal, not at all ill) in the ts-cgi-s * patients participating in other clinical trial
exploring the effectiveness of dance as an intervention to promote social-emotional health in children with autism spectrum disorder (asd)

Conditions: Autism Spectrum Disorder

Summary: this study will explore the effectiveness of dance as an intervention to promote social-emotional health within children with asd.

the study will look children with asd's response to a 7-week occupational therapy led dance program in regards to social-emotional health. this will include exploring the effect on change of social-emotional behavior in children with asd after being exposed to dance intervention through comparing the quantitative measurements of pre- and post-assessment scores of the developmental profile 4 (dp-4), analysis of the qualitative measurements of pre- and post-social-emotional behaviors via child report, and analysis of qualitative observations of social-emotional behavior through reviewing video recording of dance classes. additionally, parents' perspectives will be explored through post-interview questions to share their observations of their child's experience.

Eligibility criteria:
inclusion criteria for youth participants * elementary school children ages 7-11. * parent/caregiver/guardian must provide proof of an individualized education plan (iep) with a primary eligibility of autism. o parent/caregiver/guardian must provide proof of iep and eligibility. * will speak and understand english. * able to physically participate in the dance program without the use of adaptive equipment. * answer yes to the following skillset checklist (per parent/caregiver/guardian report): * follow 1- and 2-step instructions. * follow structured activities with supervision (e.g., visual schedule, routine). * previous participation in extracurricular group activities over the last 6 months - 1 year (e.g., structured sports). * minimum 5-minutes of attention to task. exclusion criteria: * no iep primary eligibility of autism. * no children participants younger than 7. * no children participants older than 11.
clinical study to evaluate the efficacy and safety of fb1006 in the treatment of als patients

Conditions: Sporadic and Familial Amyotrophic Lateral Sclerosis

Summary: this is a randomized double-blind controlled exploratory clinical study to evaluate the efficacy and safety of fb1006 in the treatment of amyotrophic lateral sclerosis (als) patients.

this is a randomized double-blind controlled exploratory clinical study to evaluate the efficacy and safety of fb1006 in the treatment of amyotrophic lateral sclerosis (als) patients. the study has two phases: the first phase is 24 weeks, using a randomized double-blind placebo-controlled design; the second phase is 24 weeks, using an open-label study design. fb1006 was approved by the national medical products administration（nmpa）on june 21, 2021.

Eligibility criteria:
inclusion criteria: 1. world federation of neurology modified el ecorial criteria for diagnosis of patients with laboratory support probable, clinically probable, or definite sporadic and familial amyotrophic lateral sclerosis (als) 2. age 18 to 80 years old 3. als duration no longer than 18 months(from day of onset) 4. patient 's alsfrs-r total scored ≥27，each single item is scored at least 2（dyspnoea, orthopnea and respiratory insufficiency ≥3） 5. forced vital capacity (fvc%) no less than 70% of predicted normal for gender, height and age 6. according to brain function ai analysis in accordance with depressive eeg characteristics 7. women and men of childbearing potential should use medically acceptable contraception 8. voluntarily participate, and sign an informed consent form exclusion criteria: 1. patients with dementia or severe neurological, psychiatric or systemic disease that is poorly controlled or may interfere with the conduct of the trial or the results of the trial 2. pregnant women and lactating women 3. suicide attempt or attempted suicide 4. combined with other neurological diseases similar to als symptoms, or affecting the evaluation of drug efficacy, such as cervical spondylotic myelopathy, lumbar spondylosis, dementia, etc. 5. patients with history of spinal surgery after als onset 6. alt or ast \> 2 times uln，creatinine clearance \< 60 ml/min/1.73m2 (mdrd) 7. patients who are allergic to the investigational product 8. having participated in other clinical studies within 3 months before randomization 9. patients that the investigator considers unsuitable for participation in the study
study of the safety and tolerability of switching to itca 650 in patients with type 2 diabetes receiving liraglutide

Conditions: Diabetes Mellitus, Type 2

Summary: a phase 3b, open-label, randomized, multicenter, safety and tolerability study of itca 650 in subjects with type 2 diabetes taking liraglutide and metformin.


Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes ≥ 3 months. * stable regimen of diet and exercise in combination with a stable treatment of liraglutide ≥1.2 mg/day and metformin ≥1000 mg/day. * hba1c ≤9.5%. * stable body weight ≥ 3 months. * body mass index (bmi) ≥25 to ≤45 kg per meter squared. * calcitonin \<50 ng/l (50 pg/ml) at the screening visit. exclusion criteria: * history of type 1 diabetes. * recent use or of anti-diabetic medications other than liraglutide or metformin. * history of significant/severe nausea and/or vomiting due to liraglutide. * significant symptomatic hyperglycemia. * history or evidence, within the last 6 months prior to the screening visit, of myocardial infarction, coronary revascularization (coronary artery bypass grafting or percutaneous coronary intervention), unstable angina, or cerebrovascular accident or stroke. * history or evidence of acute or chronic pancreatitis. * history of liver disease. * history of medullary thyroid cancer or a family or personal history of multiple endocrine neoplasia type 2. * poor thyroid, liver, or renal function. * serum creatinine levels \>1.5mg/dl (132 μmol/l) for male patients, or \>1.4 mg/dl (123 μmol/l) for female patients. * weight loss surgery or requires weight loss medications. * history of malignancy (not including basal or squamous cell carcinoma of the skin with past 5 years). * history of active alcohol or substance abuse. * treatment with medications that affect gi motility. * history of hypersensitivity to exenatide or liraglutide. * women that are pregnant, lactating, or planning to become pregnant.
the offer of neurosurgery care in the grand est of france during the health crisis linked to covid-19

Conditions: COVID-19 Pandemic

Summary: during this exceptional health crisis, this study of the current care of a neurosurgical activity, which is essential in a university hospital centre, will enable us to better understand how we function, the response given to a population with the means at our disposal, the implementation of new therapeutic strategies and their limits, ethical reflection, and, how to pursue a distributive and quality medicine. the restriction of conventional medical resources to our care activity (resuscitation, personnel, operating theatre, constraints linked to the risk of contamination...) is leading to a new medical organisation imposing new covid-19 standards, the description of which seems essential to us. a knowledge of the strategies to be adopted during a disaster health situation in order to continue providing care to the civilian population. how can we prevent the setting up of health care systems outside the cause of the health crisis? n triage medicine, avoiding the "burn-out" of doctors struck by the health crisis.


Eligibility criteria:
inclusion criteria: * patient aged over 18; * entering the neurosurgery care sector requiring support between 03/16/2020 and 06/15/2020; * having not expressed his opposition, after information, to the reuse of his data for the purposes of this research. exclusion criteria: * subject having expressed opposition to participating in the study * subject under guardianship or guardianship * subject under safeguard of justice

Keywords: covid-19 pandemic coronavirus sars-cov-2
evaluation of the ability of ct-based finite element analysis (ctfea) to predict fractures in patients with metastases: a randomized controlled study.

Conditions: Bone Neoplasm of Hip (Diagnosis); Orthopedic Disorder; Bone Metastases; Proximal Femoral Metaphyseal Abnormality

Summary: patients with metastases to proximal femur, who are evaluated fr the risk of pathologic fracture in order to decide on preventive fixation vs follow-up constitute the study population. the patients will be randomized in two arms. first arm - the decision of treatment will rely on conventional decision algorithm including specialist judgement and mirels' score. second arm- the decision on treatment will be supported by ctfea analysis of bone structure and quantitative simulation-based estimate of fracture risk, in addition to the conventional decision algorithm. operation rates, pathologic fracture rates and additional secondary outcomes will be compared between the two study arms.


Eligibility criteria:
inclusion criteria: 1. metastatic bone disease of femur 2. patients who undergo a ct scan (soft tissue kernel/filter, 120 kvp), and have at least 2/3 of both femurs visible in the ct scan. if ct scan is performed at the sourasky medical center it must be according to the protocol in appendix a. exclusion criteria: 1. ipsilateral previous surgery with or without implants 2. low quality ct scan or ct does not include at least 2/3 of the femurs. 3. history of fractures, radiation or surgeries in lower limbs. 4. inability to provide informed consent

Keywords: ct-based finite element analysis randomized controlled study preventive bone fixation randomized controlled trial
use of corticosteroids in third molar surgery

Conditions: Inflammation; Pain, Postoperative; Trismus

Summary: surgical extraction of retained lower third molars is associated with the development of postoperative complications, including inflammation, trismus and postoperative pain, that lead to a decrease in patients' quality of life. therefore, the use of drugs is essential to reduce the morbidity associated with surgery, with nsaids and corticosteroids being the most commonly used drugs.

surgical extraction of retained lower third molars is associated with the development of postoperative complications, including inflammation, trismus and postoperative pain. traditionally, nsaids have been used for the treatment of postoperative pain and inflammation, although corticosteroids are increasingly used in oral surgery, as they have proven to be clinically effective in reducing postoperative complications without causing serious adverse effects. although numerous studies have been carried out comparing different corticosteroids in order to determine which of them is the most effective, there is still no clinical protocol regulating the use of these drugs in oral surgery. therefore, this clinical trial is based on comparing two of the most studied corticosteroids used in oral surgery to date: dexamethasone and methylprednisolone. this study is based on the preoperative administration of 8mg of dexamethasone or 40mg of methylprednisolone via submucosa, randomly, in patients undergoing surgical extraction of a retained lower third molar, to determine which of these two drugs is more effective in the prevention of inflammation, trismus and postoperative pain.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age * indication for surgical extraction of a retained lower third molar exclusion criteria: * patients treated with corticosteroids in the last 3 months * patients treated with nsaids in the last 7 days * patients with hypersensitivity to the drug * patients with a medical condition that contraindicates the administration of the drug
complications of diabetes with puzzles

Conditions: Diabetes Complications

Summary: in this study, it was aimed to investigate the effect of diabetes complications training on endocrine system diseases and nursing care in the internal medicine nursing course on the knowledge level of nursing students.

puzzles, which are among the active learning tools, are frequently preferred today because they make learning fun, are economical, improve problem-solving skills and offer understandable learning. the student\&#39;s involvement in a fun game, his effort to find the correct information, and the feedback he receives afterwards have an important place in terms of learning. it develops students\&#39; decision-making power with a critical perspective. puzzles increase students\&#39; motivation and self-confidence by turning complex concepts into a hobby. the use of the puzzle technique in learning concepts related to theoretical knowledge is among the studies carried out in recent years. the puzzle technique is used in many fields such as pharmacology in nursing education (shawahna \& jaber, 2020), child health and diseases (kaynak et al., 2023), pain management (köse tosunöz \& deniz doğan, 2023), teaching in nursing (kalkan et al., 2022). it has been shown to have a positive effect on learning information. in this study, it was aimed to investigate the effect of diabetes complications training on endocrine system diseases and nursing care in the internal medicine nursing course on the knowledge level of nursing students.

Eligibility criteria:
inclusion criteria: * volunteering to participate in research * having course continuity exclusion criteria: * not volunteering to participate in the research

Keywords: nursing students puzzles diabetes
intracranial pressure during migraine

Conditions: Menstrual Migraine

Summary: an increase in intracranial pressure (icp) during migraine attacks is possible and could contribute to pain initiation and maintenance. from now on, it was not possible to measure icp in a non-invasive way. the development of a new tool allows non-invasive self-measures of icp variations. thus, it is possible for the first time to look for such icp variations during migraine attacks and to conclude if this mechanism is implied in the pathophysiology of migraine.

womens presenting with regular menstrual migraine treated with triptans will be included in the study. self-measure of icp will be performed outside and during menstrual migraine attacks. the potential variations will be compared to the measures done on matched healthy women outside and during menses.

Eligibility criteria:
inclusion criteria: * 18 to 50 non menopausal women * menstrual migraine * using a triptan as usual treatment to relieve attacks * usual triptan efficacy although recurrence is possible exclusion criteria: * disease of the ear * intracranial hypertension * chronic daily headache * use of topiramate or acetazolamide * triptans used more than 10 days/month * analgesic drug used more than 15 days/month * uncontrolled high blood pressure * bmi \>30 * ongoing allergic rhinitis or flu

Keywords: migraine intracranial pressure headache
axsend: exploring immune and microbiota effects of a partial enteral nutrition diet in axial spondyloarthritis

Conditions: Axial Spondyloarthritis; Ankylosing Spondylitis; Inflammation; Dysbiosis; Arthritis; Spondylitis; Spondylarthritis; SpA; AxSpA

Summary: people with axial spondyloarthritis (axspa) often have intestinal inflammation and intestinal microbiome dysbiosis, with some similarities to crohn's-like inflammatory bowel disease (ibd) gut inflammation. however, research has not addressed whether partial enteral nutrition (pen), a diet formed of a liquid formula and some solid whole foods, which is effective at inducing remission in ibd, may influence the dysbiotic microbiome and inflamed, hyperpermeable intestine of axspa patients, and whether these changes may be accompanied by alterations in systemic markers of inflammation. thus, there is a need to determine the effects of pen on these aspects in axspa patients. in this study, the investigators intend to trial a 2-week course (with optional additional 2-week extension) of a pen diet in people with active axspa disease. a group of healthy volunteers following the same diet will act as a control.


Eligibility criteria:
eligibility criteria for participants with axspa inclusion criteria. participants will fulfil all of the following: * diagnosis of axspa (fulfilling the asas criteria) * active disease (basdai score ≥4) on day of study visit * stable on treatment \[defined as (1) no major change to therapy (change in treatment type) in the preceding 3 months and (2) no minor change in therapy (adjustment of treatment dosage) in the preceding 1 month\] * age ≥ 16 years * willing and able to give informed written consent. exclusion. participants will have none of the following: * pregnancy or breastfeeding * prior diagnosis of ibd * recipient of chemotherapy/immunotherapy/radiotherapy in prior 3 months * recent systemic antibiotic use (within last 1 month) * current eating disorder * food allergy incompatible with diet (e.g. cow's milk allergy) * following a vegan diet * major surgery in prior 3 months or planned in forthcoming 3 months. * unable or unwilling to give informed consent * unable or unwilling to try the pen diet. eligibility criteria for healthy volunteer participants inclusion criteria. participants will fulfil all of the following: * age ≥ 16 years * current student and/or staff member at the university of glasgow * willing and able to give informed written consent exclusion. participants will have none of the following: * pregnancy or breastfeeding * prior diagnosis of an immune-mediated inflammatory condition * recipient of chemotherapy/immunotherapy/radiotherapy in prior 3 months * recent systemic antibiotic use (within last 1 month) * current eating disorder * food allergy incompatible with diet (e.g. cow's milk allergy) * following a vegan diet * major surgery in prior 3 months or planned in forthcoming 3 months. * unable or unwilling to give informed consent * unable or unwilling to try the pen diet.

Keywords: partial enteral nutrition nutrition axial spondyloarthritis ankylosing spondylitis axspa diet pen as
ultrasound evaluation of alveolar stress by measurement of ultrasound pleural strain in healthy subjects

Conditions: Ultrasound Strain Measurement

Summary: in the critical patient, lung ultrasound is routinely performed for acute respiratory distress, adult respiratory distress syndrome and for hemodynamic evaluation. its diagnostic performance is superior to that of chest radiography in the context of pleuropulmonary parenchymal pathologies. the search for lung sliding is performed to diagnose a pneumothorax or to search for the correct placement of the endotracheal intubation tube. however, this analysis is qualitative and is sometimes difficult to interpret. at present, there is no global evaluation technique at the patient's bed allowing to analyze simultaneously the alveolar recruitment, the pulmonary over-distension and the quality of the lung sliding, whereas the pulmonary damage is most often heterogeneous. the justification of our research project is based on the need to develop and validate a means of global and regional quantification of the mechanical and aeration properties of the lung parenchyma by the analysis of the acoustic markers of the pleura (pleural strain) by the ultrasound technique of speckle tracking. the aim is to establish the normal values of the pleural strain in healthy volunteers, in spontaneous ventilation and then in non-invasive mechanical ventilation, in order to vary the lung volume.


Eligibility criteria:
inclusion criteria: -healthy volunteer male or female between 18 and 50 years old exclusion criteria: * history of traumatic or spontaneous pneumothorax * history of connective tissue disease * any history of chronic respiratory disease * presence of an ongoing clinical respiratory ear-nose-throat (ent) or pulmonary syndrome (rhinitis, sinusitis, bronchitis, lung disease) * history of gastro-duodenal reflux or stomach surgery

Keywords: lung strain speckle tracking lung stress
the effect of oxytocin on the acquisition and consolidation of trauma-associated memories

Conditions: Intrusive Memories

Summary: the purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of ptsd.


Eligibility criteria:
inclusion criteria: * healthy female volunteers * german on a native level exclusion criteria: * former or present disorder according to the diagnostic and statistical manual of mental disorders 5 (dsm-5) * any physical illnesses * any medication intake (except oral contraceptive) * history of traumatic experience, e.g. history of sexual abuse or rape * pregnancy or lactation period * follicular phase of menstrual cycle for all women not using oral contraceptives