Kornimate/medical-research-clean huggingface dataset:
risk factors for three critical stages of the diabetic foot infections

Conditions: Diabetic Foot; Osteomyelitis

Summary: in this study, it was aimed to evaluate the independent risk factors for osteomyelitis, amputation and major amputation of the diabetic foot infection in the forward direction without using standard scoring procedures.

in this study, it was aimed to evaluate the independent risk factors for osteomyelitis, amputation and major amputation of the diabetic foot infection in the forward direction without using standard scoring procedures. patients who were applied to diabetic foot council of our setting with diabetic foot infections between 2012 and 2014 were included in the study. patients were followed prospectively and ethical approval was obtained from research ethics committee of our setting. an informed consent form was provided by each patient. diabetic foot infection was decided as local infection involving only the skin and the subcutaneous tissue or infection involving symptoms and signs more than this criterion. properties and variables of the cases were recorded during the admission process with total 57 different situations. the related characteristics were followed until the end of the treatment. osteomyelitis, amputation and factors affecting to have major amputation on the cases were investigated. in the first step, data normality tests were performed with a simple data analysis and univariate analysis was applied in the second stage to which meaningful. at the last stage, major amputation, amputation and osteomyelitis were analyzed with stepwise multiple logistic analysis (sla) model. logistic regression was subject as significant data were saved as the independent risk factor. the odds ratio and 95% ci were calculated from the beta coefficients of the variables with significant p value. p \< 0.05 was used for significance at all tests.

Eligibility criteria:
inclusion criteria: * volunteer to participate in research (an informed consent form was provided by each patient), * patient with infected diabetic foot, * the lack of mental retardation or mental disorders exclusion criteria: * the patient refused to participate in the study, * age \< 18 years. * patient's opinion or participation in another clinical trial * the patient has previously been recruited to the study. * another rapidly progressive or terminal illness.

Keywords: foot amputation osteomyelitis diabetic foot
correlation between ultrasonography finding and shoulder range of motion in stroke patients

Conditions: Cerebral Stroke; Frozen Shoulder

Summary: limitation of range of motion in the shoulder joints is common in stroke patients. the causes are stiffness, crps, and frozen shoulder. the purpose of this study was to investigate the relationship between frozen shoulder and shoulder lom in patients with cerebral infarction using ultrasonography.

ultrasound examination was performed on 50 patients with limited range of motion of the shoulder joint among inpatients or outpatients in the department of rehabilitation medicine of our hospital, who had a stroke of fewer than 2 years, and the findings suitable for adhesive capsulitis, namely the thickness of the joint capsule in the axillary concave identify those with thickened findings. their shoulder power rating, passive range of motion, stiffness evaluation (modified ashworth scale, mas), and the presence or absence of reflex sympathetic dystrophy (rsd) were evaluated, and the relationship with ultrasound findings was investigated.

Eligibility criteria:
inclusion criteria: * those who have been diagnosed with a stroke through ct or mri within the last 2 years * those who are over 19 years old * those who have limitations in the range of motion of the shoulder joint exclusion criteria: * those diagnosed with adhesive arthritis prior to the onset of stroke * patients with a severe shoulder trauma * those who performed shoulder surgery

Keywords: cerebral stroke frozen shoulder ultrasonography
extended use of polyethyleneglycol3350 laxative in constipated patients

Conditions: Constipation

Summary: to evaluate the safety and efficacy of extended use of polyethyleneglycol3350 laxative as compared to placebo in constipated patients.


Eligibility criteria:
inclusion criteria: * male or female outpatients at least 18 years of age * constipated according to rome i criteria * on average, fewer than 3 satisfactory bms per week during the observation period * if female and of childbearing potential, patient must be surgically sterilized or using oral contraceptives, depot contraceptives, intrauterine device, or testifies that she is monogamous with a vasectomized partner, or practices abstinence and will continue to do so during the duration of study * are otherwise in good health, as judged by a physical examination * in the investigator's judgment, patient is mentally competent to sign an instrument of informed consent exclusion criteria: * patients with heme positive stool at screening. patients with heme positive stool that can be attributed to hemorrhoids or anal fissures are eligible for inclusion. * patients with hypo- or hyperthyroidism as determined by history, or screening tsh results. * patients with known or suspected perforation or obstruction. * history of gastric retention, inflammatory bowel disease, bowel resection, or colostomy. * patients with a known history of organic cause for their constipation. * patients meeting the rome definition of irritable bowel syndrome * patients currently taking any of the following medications that are known to effect bowel habits: * antidiarrheals * antacids containing magnesium or aluminum salts * anticholinergics * antispasmodic agents * erythromycin and other macrolides * octreotide * lotronex, zofran, or other 5-ht3 antagonists * zelnorm, or other 5-ht4 agonists * opiods/narcotic analgesics * prokinetics * serotonin re-uptake inhibitors or tricyclic antidepressants * calcium antagonists * patients who are breastfeeding, pregnant, or intend to become pregnant during the study. * female patients of childbearing potential who refuse a pregnancy test. * patients with a known allergy to corn or polyethylene glycol. * patients who, in the opinion of the investigator, should not be included in the study for any reason, including inability to follow study procedures. * patients who, within the past 30 days have participated in an investigational clinical study * patients that have undergone a colonoscopy within 30 days of beginning the 14 day observation period. * patients that are currently taking, or have previously been treated with polyethyleneglycol3350
effects of seminal plasma on pregnancy rate with ivf

Conditions: Infertility

Summary: all couples planned for ivf will be asked to participate. after information and received informed consent they will be randomized into two groups. at the time for ovum pick up during an ivf procedure either half of the amount of seminal plasma or the same amount of physiological nacl solution will be installed around the external cervical opening in vagina. the syringe with seminal plasma or physiological nacl solution will be prepared according to a prearranged randomization list by a technician. the success rate will be the number of diagnosed pregnancies and live births.

all couples planned for ivf will be asked to participate. after information and received informed consent they will be randomized into two groups. at the time for ovum pick up during an ivf procedure either half of the amount of seminal plasma or the same amount of physiological nacl solution will be installed around the external cervical opening in vagina. normally we do not use the seminal plasma but now half of it will be installed and the other half analysed regarding a number of cytokines possibly involved in the immunological preparation of the female internal genitalia. the syringe with seminal plasma or physiological nacl solution will be prepared according to a prearranged randomization list by a technician.

Eligibility criteria:
inclusion criteria: * subjects have given informed consent * infertility for at least 1 year * the couple wishing ivf * subjects aged between 20 - 40 years exclusion criterion: * azoospermia
compare combined sphincterotomy and balloon dilation (esbd) versus standard sphincterotomy (es) in removing biliary stones

Conditions: Common Bile Duct Stone

Summary: to compare the technique of combined balloon sphincter dilation after an initial sphincterotomy and standard sphincterotomy in the endoscopic removal of large bile duct stones. the investigators hypothesize that combined balloon dilation and sphincterotomy allows for easier stone removal without added morbidities when compared to standard sphincterotomy.

endoscopic sphincterotomy is a standard technique to enlarge the bile duct opening before stone removal during endoscopic retrograde cholangiopancreatography. however, complete sphincter ablation by endoscopic sphincterotomy is not always possible. also, due to the tapering end of the distal duct, standard sphincterotomy may not be adequate for removal of particularly large stones. in a retrospective series by ersoz et al, the addition of balloon dilation after sphincterotomy achieves a high stone clearance rate (89-95%). the investigators postulate that the combination of endoscopic sphincterotomy followed by balloon dilation may allow easier stone retrieval with acceptable complication rate.

Eligibility criteria:
inclusion criteria: * patients at least 18 years old, presented to prince of wales hospital for endoscopic retrograde cholangiopancreatography (ercp) for known or suspected bile duct stones are invited to participate. * informed consent will be obtained before the beginning of ercp. * patients are randomized to est or esbd after confirming the presence of bile duct stones on the initial cholangiogram exclusion criteria: * septic shock, coagulopathy (international normalized ratio \>1.3, * partial thromboplastin time greater than twice that of control), * platelet count \<50,000x103/ul or * ampullary tumors
comparative study of experimental dental adhesive with and without phosphoric acid pretreatment

Conditions: Dental Caries

Summary: the intent of this study is to evaluate the clinical performance of an experimental dental bonding agent for use with dental restorative composites with and without pretreatment of the tooth dentin and enamel using phosphoric acid etching.

the intent of this study is to evaluate the clinical performance of an experimental dental bonding agent (adhesive) for use with dental restorative composites with and without pretreatment of the tooth dentin and enamel using phosphoric acid etching.

Eligibility criteria:
inclusion criteria: * patients in need of class i and class ii restorations in premolars and molars. exclusion criteria: * patients with fewer than 20 teeth * patients exhibiting poor oral hygiene or uncontrolled periodontal disease * pregnant women or lactating mothers * patients with known allergies to hema or resin-based materials * patients with medical conditions that would contraindicate dental treatment * patients with xerostomia
a newly modified technique for levator muscle tucking in blepharoptosis surgery: an egyptian tertiary center study

Conditions: Mild Ptosis; Moderate Ptosis

Summary: mild to moderate blepharoptosis with good levator function is usually corrected by levator muscle resection or advancement with their modifications with high success rate. levator plication technique has been strongly suggested in patients with mild to moderate ptosis, advocated by its simple and rapid recovery. its drawback is a high recurrence rate. we suggest a modified tucking technique that improves the force of eyelid elevation with preserved normal anatomy of muller's muscle and conjunctiva with less disturbance to the levator muscle aponeurosis. it is a short procedure, less complications with good aesthetic results and high patient's satisfaction.

a prospective single-centre study enrolling 180 patients with blepharoptosis at ain shams university hospitals from march 2017 to february 2019. patients of unilateral or bilateral mild to moderate ptosis with good levator function (more than 8 mm) were included. those with severe, traumatic, recurrent, mechanical ptosis, marcus-gunn jaw winking syndrome, third nerve palsy, absent bell's phenomenon, or abnormal ocular motility were excluded. the follow-up was at one week, one month, three months, six months, and one year visits. functional outcome was assessed by analysis of the upper eyelid margin position in relation to the superior limbus and classified as very good (2 mm), good (2-4 mm), poor (5 mm) and preoperative to postoperative difference in marginal reflex distance (mrd). the aesthetic outcome was assessed in the form of symmetry of eyelid height, lid contour, lid crease presence, and degree of patient's postoperative satisfaction.

Eligibility criteria:
inclusion criteria: * mild _moderate blepharoptosis exclusion criteria: * severe, traumatic, recurrent, or mechanical ptosis, third nerve palsy, marcus-gunn jaw winking syndrome, abnormal ocular motility, and absent bell's phenomenon

Keywords: ptosis, plication, levator muscle, tucking.
islet transplantation in type 1 diabetic patients

Conditions: Type 1 Diabetes

Summary: our hypothesis is that a successful clinical islet transplant program can be established at the university of wisconsin using a steroid -free, sirolimus- and low dose tacrolimus - based immunosuppressive drug regimen (edmonton protocol). we intend to answer the following research questions: 1) will treatment of islet transplant recipients with thiazolidinediones (i.e. pioglitazone) enhance post-transplant islet function and reduce the number of islets necessary to achieve adequate metabolic control? 2) which type 1 diabetic patients are optimal candidates for islet transplantation (i.e. islet transplant alone or islet after kidney transplantation)? 3) can cadaver donor pancreases, which are ordinarily discarded and not used for pancreas transplantation be used for islet transplantation?


Eligibility criteria:
inclusion criteria: * 16 type i insulin-dependent diabetic subjects ages 18-60,(8 who have received a prior kidney or liver transplant and have stable renal function, and 8 who have labile glucose regulation and who have failed a trial of intensive exogenous insulin therapy and who have preserved native renal function) exclusion criteria: * untreated proliferative diabetic retinopathy; * hgba1c \>12%; creatinine clearance \ 0.3 gm/24 hrs; * presence of panel reactive antibodies \>20%
clinical evaluation of a self-adhering flowable composite in class i cavities

Conditions: Tooth Diseases

Summary: the aim of this study is to evaluate long-term clinical performance of a self-adhering flowable resin composite in comparison with a conventional flowable resin composite used with an etch\&rinse adhesive system in minimally invasive class i cavities. twenty-five patients will receive at least one pair of class i restorations. after class i cavities were prepared they were restored either with a self-adhering flowable resin composite (vertiseflow/kerr-vr) or with a flowable resin composite (luxaflow/dmg-lx) in combination with an etch\&rinse adhesive (teco/dmg) \[according to the manufacturers' instructions. restorations will be evaluated at baseline and yearly according to fdi criteria by two evaluaters. statistical analysis will be carried out with pearson chi-square test and cochran q-test followed by mc nemar's.


Eligibility criteria:
inclusion criteria: * having no medical or behavioral problems preventing then from attending review visits, absence of previously placed restorations,having antagonist teeth exclusion criteria: * poor gingival health,uncontrolled, rampant caries,bruxism,removable partial dentures, xerostomia

Keywords: composite resin occlusal caries
taste reward processing in pediatric obesity

Conditions: Pediatric Obesity

Summary: the study aims to provide a better understanding of the neural influence of eating behavior in the development of childhood obesity. children ages 4-8 will be recruited to examine fmri brain response to pictures that signal delivery of a chocolate milkshake and to the taste itself. the brain response will be compared to body mass index percentile scores for each child to help us determine whether brain differences present in adolescents and adults with obesity are present in young children.


Eligibility criteria:
inclusion criteria: * ages 4-8 * parent available to complete surveys in english exclusion criteria: * no presence of metal in body * no claustrophobia * no psychiatric or neurological condition that will affect brain function

Keywords: picture food type taste type
dexmedetomidine and melatonin for sleep induction for eeg in children

Conditions: Electroencephalography; Child; Dexmedetomidine; Melatonin; Sleep; Epilepsy

Summary: the aim of the study is to compare the effect of melatonin, given orally, dexmedetomidine, given intranasally, and dexmedetomidine given sublingually on sleep induction, sleep duration, their possible impact on vital functions and technical implementation of eeg.

at university medical centre ljubljana (umcl; slovenia), the investigators use electroencephalography (eeg) in wakefulness and sleep for diagnostic and therapeutic purposes in children with (suspected) epilepsy. since epileptiform activity can only be detected during sleep in some patients and because children with intellectual disabilities have sometimes problems with cooperation, eeg in induced sleep is required. in this study, the investigators will enroll 150 children who need eeg recorded in their sleep. the investigators will compare safety and efficacy of the two active substances, one of which will be given in two possible routes. fifty children will receive melatonin in the form of a syrup orally, 50 children will receive dexmedetomidine intranasally in the form of a nasal spray, and 50 children will receive dexmedetomidine sublingually. the investigators will monitor the following parameters: the time in which the child falls asleep, vital functions during sleep (blood pressure, blood oxygen saturation, respiratory rate frequency and heart rate frequency), the impact on the technical implementation of eeg, the depth of sleep and waking time. all parents will give their written consent for their child to participate in the study.

Eligibility criteria:
inclusion criteria: * age between 1 and 20 years * referral for eeg in sleep * children/young adults whose parents/caregivers were informed about the aims of the study and have signed the informed consent form exclusion criteria: * children that were unable to follow the study protocol were excluded during the study

Keywords: child dexmedetomidine melatonin electroencephalography autism spectrum disorder developmental delay disorder epilepsy sleep sleep induction
one anastomosis gastric bypass for severe obesity in 6,722 patients: early outcomes from the assuta surgery registry

Conditions: Morbid Obesity

Summary: background: one-anastomosis gastric bypass (oagb) is an emerging type of bariatric metabolic surgery (bms). our study aimed to evaluate the short-term (≤30-day) postoperative safety of oagb. methods: electronic medical records of all oagbs performed between january 2017 and december 2021 at a high-volume bariatric center in israel were scanned using the mdclone software. data regarding patients' characteristics, surgical procedure, ≤30-day postoperative complications, and their classification according to clavien-dindo grade were gathered. moreover, multivariate logistic regression analysis was used to identify factors related to early postoperative complications after oagb. results: a total of 6,722 patients underwent a primary (74.1%) or revisional (25.9%) oagb procedure at our institution during the study period. their preoperative mean age and body mass index (bmi) were 40.6±11.5 years and 41.2±4.6 kg/m2, respectively, and 75.0% were females. respective mean operating time and length of stay were 67.3±26.6 minutes and 2.2±1.4 days. complications occurred in 258 patients (3.8%), and include mainly bleeding (n=133, 2.0%), leaks (n=32, 0.5%), and obstruction/strictures (n=19, 0.3%). according to clavien-dindo classification, complication rate for grades 1-2 and grades 3a-5 were 1.6%; and 1.4%, respectively. the mortality rate was 0.03% (n=2). the rate of readmission and reoperation were 1.9% and 0.9%, respectively. age ≥60 years, ≥3 hours of operating room time, and cholecystectomy concomitant with oagb were independent predictors of early post-oagb complications. conclusions: oagb was found to be a safe primary and revisional bms procedure in the ≤30-day postoperative term. the most common early complications were gastrointestinal bleeding (2.0%), leak (0.5%), and stricture (0.3%).


Eligibility criteria:
inclusion criteria: * age ≥18 years old, patients who received approval to undergo bariatric and metabolic surgery by assuta medical centers' bariatric committee, patients who have undergone primary or revisional oagb surgery at abcs, and patients who had complete follow-up data of 30-day post-procedure. exclusion criteria: age ≤ 18 years old -

Keywords: severe obesity, bariatric surgery, one anastomosis gastric bypass, early postoperative complications
sodium bicarbonate to treat severe acidosis in the critically ill

Conditions: Metabolic Acidosis

Summary: the purpose of the present study is to compare the adjunct treatment of metabolic or mixed severe acidosis in the critically ill using sodium bicarbonate as a buffer to increase the plasma ph vs no buffering therapy. the study is a randomized multiple center clinical trial with the outcome as a primary endpoint.

* design: randomized multiple center clinical trial, open label * arms: intravenous 4.2% sodium bicarbonate vs no additional treatment * inclusion: age of 18 yo or above, critically ill patient with a sofa score of 4 or above, lactatemia of 2mmol/l or above, with ph of 7.20 or below and paco2 of 45mmhg or below and bicarbonatemia of 20mmol/l or below * exclusion: single respiratory disorder (paco2 \> 50 mmhg, bicarbonatemia equal or higher than (paco2-40)/10 + 24 ; acute diarrhea, ileostomy or biliary drainage ; stage iv kidney failure or chronic dialysis ; tubular acidosis, ketoacidosis, high anion gap acids poisoning (peg, aspirin, methanol) ; paco2 equal to 45mmhg or above and spontaneous breathing, pregnancy, protected patients, moribund patient (life expectancy of 48h or below) * randomization: website randomization with stratification on age, presence of sepsis at inclusion, renal failure * intervention: experimental arm: intravenous 4.2% sodium bicarbonate 125 to 250ml in 30min up to 1000ml/24h. the target is a plasma ph of 7.30 or above. * an interim statistical analysis is planned when 200 patients will be included

Eligibility criteria:
inclusion criteria: * age of 18 yo or above, * critically ill patient with a sofa score of 4 or above, * lactatemia of 2mmol/l or above, with ph of 7.20 or below and paco2 of 45mmhg or below and bicarbonatemia of 20mmol/l or below exclusion criteria: * administration of sodium bicarbonate 24 hours before inclusion * single respiratory disorder (paco2 \> 50 mmhg, bicarbonatemia equal or higher than (paco2-40)/10 + 24 * acute diarrhea, ileostomy or biliary drainage * stage iv kidney failure or chronic dialysis * tubular acidosis, ketoacidosis, high anion gap acids poisoning (peg, aspirin, methanol) * paco2 equal to 45mmhg or above and spontaneous breathing, pregnancy, protected patients, moribund patient (life expectancy of 48h or below)

Keywords: acidosis shock sodium bicarbonate renal replacement therapy