Kornimate/medical-research-clean huggingface dataset:
a novel sandwich technique of minimally invasive keratoplasty for corneal perforation

Conditions: Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique

Summary: the goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (stmik) by using smile-extracted lenticules for treatment corneal perforation and effectiveness. the main question\[s\] it aims to answer are: 1.corneal perforations require urgent attendances for prompt treatments. how can we restore the integrity of the eyeball as soon as possible, reduce complications, and restore vision in the case of lack of corneal material according to the conditions that may be obtained. 2.in china, nearly 1 million lenticules are obtained through all-femtosecond surgery every year. how to reuse and turn waste into precious materials for clinical application is an important study. participants will understand and signed the informed consent to take this new method for the treatment of their corneal perforations disease, which will obtain good results, but there may be a certain risk of complications.the main tasks participants will be asked to cooperate as required.the clinical eye check includes the test of includes visual acuity, slit lamp, anterior segment phase, anterior segment oct and iop.


Eligibility criteria:
inclusion criteria: 1. patients with corneal perforation who are willing to undergo treatment with this new technique; 2. the size of cornea perforation was ≦ 3mm exclusion criteria: 1. the size of cornea perforation was \&gt;3mm 2. patients with corneal perforation who were unwilling to be treated with this new technique. 3. patients who could not be followed up regularly.

Keywords: corneal perforation, corneal stromal lenticule,sandwich technique
an observational pilot study of the effects of traumatic haemorrhagic shock and resuscitation on the microcirculation

Conditions: Traumatic Haemorrhagic Shock

Summary: haemorrhage following major trauma is an important preventable cause of death. those patients who survive may have a prolonged period of debility caused by failure of key body organs. we suspect that an important contributor to this organ failure may be dysfunction in the network of small blood vessels that supply the bodies organs with oxygen and nutrients. our study will examine the link between the microcirculation and organ failure in patients who have suffered significant bleeding after traumatic injury. we will also explore the relationship between resuscitation of the global circulation (blood pressure, cardiac output etc.)an area that is monitored in clinical practice with the state of the microcirculation, which by contrast is not monitored. patients with severe traumatic injury commonly have problems with blood clotting. some researchers have suggested that microcirculatory failure may be an important contributor to this problem and we will explore this in more detail. finally, we will attempt to examine some of the mechanisms by which the microcirculation may be disrupted by trauma and subsequent bleeding. these may include inappropriate activation of white blood cells, inadequate function of oxygen carrying red blood cells and changes to the cells lining the small blood vessels. we will use a non invasive method to assess the microcirculation termed side stream dark field microscopy. this involves recorded a video image of the movement of blood within the small blood vessels under a patients tongue. in addition we will use ultrasound to assess the flow of blood from the heart. small samples of blood will be taken to assess blood clotting and to look at possible mechanisms of microcirculatory dysfunction. we aim to study ten patients in the first instance. the study will be carried out within the intensive care units at kings college hospital.


Eligibility criteria:
inclusion criteria history of traumatic injury received blood products prior to icu admission exclusion criteria: not expected to survive 24 hours

Keywords: microcirculation trauma haemorrhage shock
d vitamin and alveolar macrophages in idiopathic pulmonal fibrosis

Conditions: Idiopathic Pulmonary Fibrosis (IPF)

Summary: the goal of this observational study is to gain deeper insights into human macrophages and vitamin d, and their interplay, within idiopathic pulmonary fibrosis (ipf). the overall questions, it aims to answer, are the following: do ipf patients suffer from systemic and local (pulmonary) insufficient levels of vitamin d? do ipf patients suffer from pro-fibrotic and pro-inflammatory pulmonary macrophages?


Eligibility criteria:
inclusion criteria: * a clinical diagnosis of ipf, non-ipf ild or lung cancer * a signed informed consent exclusion criteria: * do not speak danish/do not understand danish

Keywords: idiopathic pulmonary fibrosis pulmonary macrophages alveolar macrophages vitamin d soluble cd163 soluble cd206
airvo 3 respiratory rate validation study

Conditions: COPD; Healthy Volunteers

Summary: this is a clinical performance testing to validate the accuracy of the airvo 3 device with respiratory rate algorithm manufactured by fisher \& paykel healthcare for continuous respiratory rate monitoring.

the airvo 3 device is intended to provide high flow warmed and humidified respiratory gases for administration to spontaneously breathing patients in hospitals and sub-acute facilities. the device has recently been updated with a new feature which allows continuous monitoring of patient's respiratory rate during nasal high flow therapy. this study, therefore, aims to validate the accuracy of the respiratory rate output of the airvo 3 device. the respiratory rate output of the airvo 3 device will be compared to the respiratory rate output of a gold standard reference device (capnography) in healthy volunteers and copd patients to determine the level of agreement between the respiratory rate outputs of the two devices. in addition, the respiratory rate output of the airvo 3 device will be compared to the respiratory rate output of a united states food and drug administration (u.s. fda) cleared pulse oximeter in healthy volunteers and copd patients to determine the level of agreement between the respiratory rate outputs of the two devices.

Eligibility criteria:
inclusion criteria: group a * healthy adults with no known history of respiratory disease * ability to provide written informed consent * ability to comply with study procedures and duration group b * out-patient adults with stable copd: global initiative for chronic obstructive lung disease (gold) stages 2 - 4 * ability to provide written informed consent * ability to comply with study procedures and duration exclusion criteria: * pregnancy or lactation * inability to tolerate nasal prongs * history of severe contact allergies to standard adhesives, latex or other materials found in pulse oximetry sensors, electrocardiogram (ecg) electrodes, or other medical sensors * inability to provide consent * participants considered to be medically unsuitable to participate in the trial

Keywords: high flow therapy respiratory rate monitoring
stellate ganglion block to treat long covid 19 case series

Conditions: Long COVID; Long Covid19; Post-COVID-19 Syndrome; Post Acute COVID-19 Syndrome; Dysautonomia; Anosmia; Dysgeusia; Brain Fog; Muscle Pain; Shortness of Breath; Dizziness; Fatigue Post Viral; Cough; Menstrual Cycle Abnormal; Pain

Summary: an assessment of the effectiveness of stellate ganglion block in alleviating symptoms of long covid-19.

we evaluated the treatment results of 41 patients (18 male and 23 female) aged between 18 and 89, who received stellate ganglion block (sgb) with ultrasound guidance for long covid-19 syndrome. the patients were from the united states and received treatment at our colorado clinics during the period of september to december 2022.those who responded to our post-procedure follow-up calls were included in the study population.

Eligibility criteria:
inclusion criteria: people who scheduled themselves for a sgb in our clinics in colorado. - exclusion criteria: stellate ganglion block contraindications -
clinical metagenomic of post-traumatic infections

Conditions: Fractures, Bone; Infections

Summary: treatment of fracture related infection is challenging and often lead to failure in such situation that carry a high health cost burden. these infections are often polymicrobial, making the identification of all involved microorganisms a major concern to provide tailored antibiotic treatment. culture-independent methods are needed to better represent the microbial diversity of infected wounds. metagenomic sequencing might lead to an accurate microbiome characterization in infected trauma-related wound. preliminary studies have reported results of metagenomic sequencing in diabetic foot infection but data focusing on non-diabetic infected patients are scarce. the impact of post-traumatic infected wound microbiome needs to be assessed, with regards to bacterial abundance, diversity including at the strain level and functional genes, along with their longitudinal evolution and association with clinical outcomes.

dna will be extracted from samples carried out during surgical procedures. different extraction protocols will be assessed to determine the best to be used for this type of tissue samples. purified dna will be quantified using the qubit dsdna high-sensitivity assay kit (invitrogen). the quality of the fragment length will be estimated with the dna high-sensitivity kit in the 2100 bioanalyzer (agilent technologies). dna sequencing will be performed with oxford nanopore technologie devices: miniontm and gridiontm. another sequencing of the same samples will be performed on the miseq after libraries preparation using the nexteraxt dna library preparation kit (illumina). sequenced otu from both sequencing methods will be confronted at different taxonomic ranks and compared with conventional routine method results (bacterial culture). a functional analysis of sequences will be done to identify potential genes associated with clinical outcome.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * diagnosis of trauma-related infection exclusion criteria: * participation in an interventional research during the study * patient opposition * absence of bone or soft tissue samples stored at -80°c

Keywords: high throughput sequencing nanopore diagnosis trauma microbiome infection
transfusion of convalescent plasma for the early treatment of pneumonia in covid-19 patients

Conditions: Covid19; Coronavirus Infection; Pneumonia, Viral

Summary: this is a multicenter open-label randomized study for the early treatment of pneumonia due to sars-cov2 with transfusion of convalescent plasma. patients with pneumonia due to sars-cov-2 will be randomized to receive or not convalescent plasma collected by recovered patients with previous diagnosis of covid19

this is a multicenter open-label randomized study for the early treatment of pneumonia due to sars-cov2 with transfusion of convalescent plasma. patients with sars-cov2 pneumonia not requiring mechanical ventilation (both non invasive and invasive) will be randomized to receive or not convalescent plasma. patients in the plasma group will receive 200-300 ml of plasma collected by recovered patients with previous diagnosis of covid19, plus standard therapy; patients in the control group will receive the standard therapy. a rescue therapy will be allowed in case of clinical worsening. patients will be followed until day n30 from randomization.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * adult patients with positive rt-pcr test for sars-cov2 (nasal swabs or lower respiratory tract sample), diagnosed with pneumonia (\<= 10 days) according to the following definitions: * suggestive radiological imaging (ct, rx, ultrasound); * respiratory failure not fully explained by heart failure or fluid overload; * pao2/fio2 200-350 mmhg; * signed informed consent exclusion criteria: * need of non invasive or invasive mechanical ventilation at the time of randomization; * pao2/fio2 \<200; * patients with hypersensitivity or allergic reaction to blood products or immunoglobulins; * patients who expressly refuse to adhere the clinical study; * use of il-6 receptor inhibitors, il-1 inhibitors, jak inhibitors, tnf inhibitors; * patients participating to other clinical trial.

Keywords: plasma
liposomal bupivacaine versus standard bupivacaine plus dexamethasone in quadriceps sparing femoral nerve block and wound infiltration for total knee arthroplasty

Conditions: Osteoarthritis; Pain, Postoperative

Summary: the purpose of this study is to compare the efficacy and duration of pain relief after total knee arthroplasty provided by a single injection of liposomal bupivacaine (exparel®) versus standard bupivacaine with an adjuvant, dexamethasone when administered as a quadriceps sparing femoral nerve block and periarticular injection. it is hypothesized that liposomal bupivacaine is superior to standard bupivacaine with dexamethasone and will decrease time to discharge readiness.


Eligibility criteria:
inclusion criteria: * adult patients of american society of anesthesiologist (asa) i-iii physical class with a pre-operative diagnosis of primary osteoarthritis scheduled for elective primary total knee arthroplasty. * patients must be living independently at home prior to undergoing primary total knee arthroplasty with intention of discharge directly to home after hospitalization exclusion criteria: * subjects will not be eligible for this trial if they have a history of allergy to a local anesthetic * known peripheral neuropathy * known connective tissue or immunological disorders * stroke or other known central nervous system disorders * renal dysfunction * hepatic dysfunction * cardiac dysfunction other than hypertension * pregnant subjects * immunosuppression * human immunodeficiency virus (hiv) * alcohol or drug abuse * chronic pain or opioid dependence * coagulopathy or those unable to comply with study requirements.

Keywords: primary total knee arthroplasty liposomal bupivacaine
system interventions to achieve early and equitable transplants (steps) study

Conditions: Chronic Kidney Diseases

Summary: this project will study how kidney care for everyone despite race can reduce racial differences in care and improve access to kidney transplants, and specifically living donor kidney transplants (ldkt), for individuals with chronic kidney disease. a study focused on equality and patient needs (called 'steps') will 1) create a program to identify people who may need a kidney transplant ('steps surveillance') and find people in health systems who may be able to receive kidney transplants early in their care and (2) study how well the 'steps outreach' program works (comprised of transplant social workers and transplant coordinators who focus on equality and patient needs) compared to usual care to improve access to kidney transplants among black and non-black individuals as well as to improve access to transplants for everyone.


Eligibility criteria:
inclusion criteria: * ability to provide oral informed consent * male or female, aged 18 to \<=75 years * presence of ckd (2 egfrs \<60, 90 days apart) and at least 1 of the following: most recent egfr less than 30 or kfre greater than 10% * english speaking with adequate ability to hear and understand questions over the phone * willing to comply with all study procedures and be available for the duration of the study exclusion criteria: * male or female, aged \ 75 years * non-english speaking * lack of ability to hear and comprehend verbal communication. * patients on dialysis * deceased * hospice/palliative care * prior kidney transplant * currently waitlisted at any transplant center * self-reported terminal illness or receipt of hospice services

Keywords: kidney transplant living donor kidney transplant
performance of different application regimens of actinica® on protection from uvr-induced erythema after one day of sun exposure in fair-skinned healthy subjects.

Conditions: Healthy Subjects, Male or Female, of 18-60 Years Old, With Phototype I, II or III, Not Pre-treated/Pre-protected Skin

Summary: study objective to assess the performance of different application regimens of actinica® on protection from uv rays-induced erythema throughout 1 day of sun exposure in fair-skinned healthy subjects (phototype i to iii). study centers a total of 20 subjects will be enrolled in 1 site in france. methodology this will be a monocentre, randomised, controlled, investigator-blind, intra-individual comparative clinical investigation. there will be a total of 6 visits for each subject. each subject will participate for a period of maximum 35 days. study population healthy subjects, male or female, at least 18-60 years old, with phototype i, ii or iii, not pre-treated/pre-protected skin, meeting specific inclusion/exclusion criteria. the clinical investigation will be conducted in 2 parts. part 1 - spf determination: to determine the spf of actinica® with application of two different amounts (0.8 and 2 mg/cm2). part 2 - sun exposure: to assess the performance of the different application regimens of actinica® on protection from uvr-induced erythema throughout 1 day of sun exposure.


Eligibility criteria:
inclusion criteria: 1. male or female, 18-60 years of age, 2. subject with phototype i, ii or iii, 3. subject with individual typology angle (ita) 28-70°, 4. subject with healthy skin / not tanned on the back, exclusion criteria: 1. subject with obvious skin cancer forms within the test areas, 2. subject with hairs on the treated area that might interfere with clinical investigation assessments, 3. subjects who have performed sun bathing at least four months before enrolment, 10. history of sun allergy / mallorca acne, active photo induced or photo aggravated disease, or abnormal response to the sun (e.g., photosensitive dermatoses, polymorphic light eruption, solar urticaria, systemic lupus erythematosus, or dermatomyositis). 11. the subject has received, applied or taken the forbidden treatments within the specified time frame prior to the day 0 visit (list available on request)
effectiveness of the mediterranean diet on weight loss after endoscopic bariatric treatmen

Conditions: Obesity; Obesity, Morbid

Summary: all participants were weighed every week for 24 weeks, wearing light clothes to the nearest 0.1 kg, using a body composition analyzer. height was determined during the first clinic evaluation using a fixed wall stadiometer to the nearest 0.1 cm, in standing position. intervention: participants followed a liquid diet plan during the first week after the endoscopic bariatric procedure (bioenterics intragastric balloon - bib - or primary obesity surgery endoluminal - pose -). subsequently, subjects were randomly assigned either a mediterranean-style or a protein diet plan. energy intake was calculated according to the spanish consensus on bariatric endoscopy. the hypothesis of this project is to analyze whether the mediterranean-style diet is more effective compared with the open protein diet plans in weight loss and weight relapse in subjects with obesity who underwent endoscopic bariatric therapies.


Eligibility criteria:
inclusion criteria: * no previous gastric intervention * no hiatus hernias * not being pregnant or in breastfeeding * not having cardiac problems, and having regular values in coagulation and blood count, * having a positive psychological evaluation. exclusion criteria: * lack of compliance with the dietary treatment * adverse effects of the surgery * refuse to complete the treatment * lack of adherence

Keywords: endoscopic bariatric treatment excess weight loss excess body mass index mediterranean diet plan open protein diet plan
a study to evaluate the efficacy and of stillen tab. and to demonstrate the non-inferiority of stillen tab.

Conditions: Acute Gastritis; Chronic Gastritis

Summary: this is a multicenter, active-controlled, randomized, double-blinded, paralleled group clinical study to evaluate the efficacy of 4-week treatment with stillen tab. in patients with acute or chronic gastritis. subject will receive stillen tab or mucosta tab., three times a day for four weeks.


Eligibility criteria:
inclusion criteria: * age is over 20 years old, under 75 years old, men or women * patients diagnosed with acute or chronic gastritis by gastroscopy * patients with one or more erosions found by gastroscopy * signed the informed consent forms exclusion criteria: * patients with peptic ulcer and gastroesophageal reflux disease * patients administered with prokinetics, h2 receptor antagonists, proton pump inhibitors, anticholinergic drugs or non-steroid anti-inflammatory drugs prior to study in 2 weeks * patients with surgery related to gastroesophageal * patients with zollinger-ellison syndrome * patients with any kind of malignant tumor * patients administered with anti-thrombotic drugs * patients with significant cardiovascular, pulmonary, heptic, renal, hemopoietic or endocrine system primary disease * women either pregnant or breast feeding
research online tele-rehabilitation program in people after a stroke living at home

Conditions: Stroke

Summary: telerehabilitation refers to the use of information and communication technologies (ict) to provide rehabilitation services to people remotely in their homes or other environments. by using ict, patient access to care can be improved and the reach of clinicians can extend beyond the physical walls of a traditional healthcare facility, thus expanding continuity of care to persons with disabling conditions. the concept of telecare, when telerehabilitation is used to deliver services to patients in their homes or other living environments, empowers and enables individuals to take control of the management of their medical needs and interventions by enabling personalized care, choice and personal control research goal and objectives 1. to investigate the clinical feasibility and usability of the gertner tele-motion-rehab system in post-stroke patients, in their homes. 2. to evaluate gertner tele-motion-rehab system clinical improvement within the patient's home in terms of: 1. function of the weak upper extremity 2. performance of adl


Eligibility criteria:
inclusion criteria: * 6-72 months post stroke * sitting balance intact (ability to go beyond the midline of the body) * moderate impairment of the affected upper extremity determined by range of motion (rom); shoulder flexion and abduction must be more than 45 degrees with mild to moderate compensations; elbow flexion should be about 45 degrees and trunk movement of about 10 cm. * basic ability to independently use the tele-system via touching virtual objects on the screen. * having a personal computer (at least intel i3 processor, with win7 operating system),internet access (10mbps) and a large computer monitor (at least 26") at home. * caregiver, available when needed, toprovide support throughout the intervention. exclusion criteria: * other medical conditions limiting participation in low-intensity exercise training. * major receptive aphasia and screening criteria consistent with dementia (mini-mentalstate score \<24). * untreated major depression. * presence of unilateral spatial neglect as determined by star cancellation (score less than 51). * hemianopsia * apraxia (limb and ideomotor) * other medical conditions that affect the central or peripheral nervous system * ataxia

Keywords: telerehabilitation stroke virtual reatlity