Kornimate/medical-research-clean huggingface dataset:
the effect of halophyte-based cream on pain and itch

Conditions: Pain, Acute; Itch

Summary: in this study the investigators wish to investigate whether halophyte-based cream applied to the skin can reduce itch applied by means of small needles from the plant mucuna pruriens (also called cowhage) or by histamine (an itch-evoking substance formed in the human body). further, the investigators wishes to investigate whether long-term application of halophyte-based cream has a pain-relieving effect on heat/cold and pinprick stimulations.

salt-tolerant plants (also called halophytes) can grow in saline soil or directly in salt water (e.g. along coasts). for centuries, these plants have been used in folk medicine, and among other things they are believed to have pain-relieving and anti-inflammatory effect. even though experiments have already investigated halophytes as a pain relieving substance, the mechanisms in relation to pain and/or itch are still unknown. therefore, the investigators wish to investigate whether halophyte-based cream applied to the skin can reduce itch applied by means of small needles from the plant mucuna pruriens (also called cowhage) or by histamine (an itch-evoking substance formed in the human body). further, the investigators wishes to investigate whether long-term application of halophyte-based cream has a pain-relieving effect on heat/cold and pinprick stimulations.

Eligibility criteria:
inclusion criteria: * healthy men and women * 18-60 years * speak and understand english exclusion criteria: * pregnancy or lactation * drug addiction defined as any use of cannabis, opioids or other drugs * previous or current neurologic, musculoskeletal or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.) * lack of ability to cooperate * current use of medications that may affect the trial such as antihistamine medications or pain killers * skin diseases * consumption of alcohol or painkillers 24 hours before the study days and between these * acute or chronic pain * participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
ankle arthrodesis nail for 2-level pathologic tibial fracture

Conditions: Bone Metastases; Fracture Nonunion; Bone Lesion

Summary: tibial pseudarthrosis in 83 year old patient suffering from pathologic fractures

the arthrodesis nail for hind foot problems is used as salvage for tibial fractures after failed plate fixation,

Eligibility criteria:
inclusion criteria: - old age, fragility fracture, tibia exclusion criteria: * active osteomyelitis

Keywords: fragility fracture, old age
effectiveness of a distance eduaction course for prevention in rsi/wrmd

Conditions: Work-related Injury

Summary: repetitive strain injuries (rsi) or work-related ostomuscular disorders (wrmd) are musculoskeletal disorders. nursing is one of the categories of workers most affected, due to the inherent functions they perform in their daily activities. the objective of this study is to evaluate the effects of a distance education program of prevention in ris/wrmd on the quality of life of a nursing group.

repetitive strain injury (rsi) or work-related musculoskeletaldisorders (wrmd) are the names given to skeletal muscle disorders that mainly affect the upper limbs, the scapular region and the neck. one of the most affected categories is nursing workers who present health problems inherent to the function they perform in their daily activities. due to this peculiarity, several studies are focused on the occupational risks of nursing workers in the hospital environment. however, it was not found in the literature studies that suggests strategies to prevent and improve the worker's quality of life. distance education comes as a differential. it has power in interactive media and collaborative learning beyond self-learning and mass media. this research project proposes to carry out a randomized clinical trial where the intervention group will receive a prevention course in rsi/wrmd in the distance education modality and the control group will receive educational lectures on prevention in rsi /wrmd, both groups will be composed by a nursing team from the clinical hospital of porto alegre.

Eligibility criteria:
inclusion criteria: * nurse staff from hcpa * male and female * individuals that agree to participate of the distance eduacational course * individuals that agree to participate in the research by signing the term of free and clarified consent exclusion criteria: * individuals that do not complete the course * individuals that do not agree to participate in the research by signing the term of free and clarified consent * individuals with chronic musculoskeletal injury diagnosed.

Keywords: nursing distance education rsi/wrmd
heart failure optimization study

Conditions: Sudden Cardiac Death; Sudden Cardiac Arrest; Heart Failure; Heart Failure Low Output

Summary: this study is designed as a multi-center prospective observational study of newly diagnosed heart failure (hf) patients to test the hypothesis that additional ejection fraction (ef) recovery occurs between 90 and 180 days as guideline directed medical therapy (gdmt) is achieved. although the study doesn't start until day 90, all eligible, consenting patients will be entered into a registry at the start of wearable cardioverter defibrillator (wcd) use. the pre-study registry will allow us to collect early (90 day) outcomes and data in those patients who are likely to be eligible for the study at day 90, or are eligible, but refuse the study at day 90.

this study will be conducted at thirty to sixty sites, initially in us and europe. it will be used to observe the rate of recovery of ventricular function (ef\>35%) between 90 and 180 days in newly diagnosed hf patients who were prescribed the wcd ≤ 10 days post-discharge after hospitalization for a primary reason of new onset hf (≤30 days since first hf hospitalization), with ischemic or non-ischemic cardiomyopathy, and have already used a wcd for 90 ± 14 days. for the first 90 days of wcd use, patients will be enrolled in a pre-study registry. the fda-approved wcd will be prescribed for up to 6 months of use after hospital discharge, with the option for longer use under physician discretion. approximately 870 subjects will enroll into the pre-study registry and 750 subjects into the study.

Eligibility criteria:
inclusion criteria: phase 1 (registry phase) * patients (≥18 years old) who were prescribed the wcd ≤ 10 days post-discharge after hospitalization for a primary reason of new onset hf (≤30 days since first hf hospitalization), with ischemic or nonischemic cardiomyopathy, and have used the wcd for no more than 30 days. * patients who had an ef ≤ 35% during index hospitalization (must be last measurement if performed multiple times). phase 2 (study phase) * patients who completed phase 1 and used a wcd for 90 ± 14 days. exclusion criteria (both phases): * patients under 18 years old. * patients who have an active unipolar pacemaker. * patients with a physical or mental condition that could impair their ability to properly interact with the device. * patients currently participating in another clinical study. * patients with any skin condition that would prevent wearing the device. * patients with an advanced directive prohibiting resuscitation. exclusion criteria (phase 2) * patients who have a qrs duration of ≥135 ms and are planned for cardiac resynchronization therapy. * patients with recent myocardial infarction or coronary revascularization (since start of wcd wear; i.e. 0-90 days of wcd wear).

Keywords: sudden cardiac death (scd) sudden cardiac arrest (sca) heart failure (hf) heart failure with reduced ejection fraction (hfref) guideline directed medical therapy (gdmt) guideline recommended medical therapy (grmt) wearable cardioverter defibrillator (wcd)
continued access protocol: demonstration of the safety and effectiveness of recell® combined with meshed skin graft for reduction of donor area in the treatment of acute burn injuries

Conditions: Burns

Summary: the overall purpose of this is study to provide continued access to the recell device following completion of protocol ctp001-6, and allow for collection of supplementary clinical outcome data for the recell device when used as an adjunct to meshed grafts in subjects with acute thermal burn injuries who require skin grafting for closure of burn injuries.


Eligibility criteria:
inclusion criteria: 1. the subject requires skin grafting as a result of an acute thermal burn injury (i.e. injuries caused by exposure of the skin to fire/flames, excessive heat, hot steam or water). 2. the area of total burn injury is 5-50% tbsa inclusive. 3. two areas requiring skin grafting, each at least 300cm2 (or 600cm2 contiguous), excluding hand/face and joints. 4. the subject is at least 5 years of age. 5. the subject (or family, for those under 18 years of age) is willing and able to complete all follow-up evaluations required by the study protocol. 6. the subject is to abstain from any other treatment of the wound(s) for the duration of the study unless medically necessary. 7. the subject agrees to abstain from enrollment in any other interventional clinical trial for the duration of the study. 8. the subject and/or guardian are able to read and understand instructions and give informed, voluntary, written consent. exclusion criteria: 1. the subject's burn injuries were caused by chemicals, electricity, and/or radioactive substances. 2. the subject is unable to follow the protocol. 3. the subject has other concurrent conditions that in the opinion of the investigator may compromise patient safety or study objectives. 4. the subject has a known hypersensitivity to trypsin or compound sodium lactate for irrigation (hartmann's) solution. 5. life expectancy is less than 1year.
the fever and antipyretic in critically illness evaluation study

Conditions: Fever; Hyperthermia

Summary: the purpose of this multination multicenter observational study is to determine the impact of fever and antipyretic on outcomes in critically ill patients.

fever is common in critically ill patients.antipyretic therapy for fever is routinely performed in intensive care.there are studies to assess the relationship between fever and mortality in non-neurological icu. however, all of them did not have any information of antipyretic therapy. there are two small, single center rct, which suggested a potential risk for antipyretic therapy. thus, a large rct might be ethically difficult. it is unfortunate that there is not enough information on how the investigators should control body temperature in non-neurological critically ill patients, because fever is a very common physiological abnormality in this cohort. from the beginning, it would, therefore, be desirable to understand several aspects of fever and antipyretic therapy in icu patients, as 1)how often fever occurs in our icus, 2)to what degree fever is independently associated with mortality?, 3)how often antipyretic therapy is prescribed?, 4)how effectively antipyretic can decrease temperature?, 5)how different is lowering temperature with medications compared with cooling?, 6)to what degree antipyretic is independently associated with mortality? thus, the investigators plan to address these questions by conducting a multi-national multi-center prospective observational trial, named "the fever and antipyretic in critically illness evaluation study" (the face study)

Eligibility criteria:
inclusion criteria: * adult non-neurological critically ill patients (20 years old or older). * icu patients expected to require intensive care for more than 48 hour. exclusion criteria: * patients with brain injury (suspected or proven)

Keywords: fever antipyretic infection mortality cooling non steroid anti inflammatory drugs acetaminophen steroid icu intensive care critically ill
effects of vr training on balance and fall risk of patients with copd

Conditions: COPD (Chronic Obstructive Pulmonary Disease)

Summary: the aim of this study is to determine whether virtual reality (vr) training has significant effects on balance and fall risk of patients with copd, with a focus on the patient group (gold standard i \& ii). additionally, the study determines whether vr training is a reliable substitute for traditional physical therapy balance.

chronic obstructive pulmonary disease (copd) is the forth leading cause of mortality worldwide. copd often impairs balance due to decreased physical activity, muscle weakness, and compromised respiratory function. virtual reality training addresses these issues by offering an immersive and engaging environment that enhances patient motivation and adherence to rehabilitation. the technology allows for personalized and controlled balance exercises, progressively increasing the difficulty to match the patient's skill level and providing real-time feedback. by integrating cognitive and motor tasks, vr promotes a comprehensive approach to balance training, improving sensory integration and postural control. research indicates that vr training can enhance both static and dynamic balance, helping patients maintain stability in various conditions. it improves the integration of sensory inputs crucial for balance, while also contributing to muscle strength and endurance. this results in a reduction in fall frequency, as patients become more adept at managing balance and are less likely to fall during daily activities. additionally, vr training teaches specific fall prevention strategies and boosts patient confidence, which further mitigates the fear of falling-a common issue among copd patients. incorporating vr training into physical therapy programs for copd patients can be highly beneficial. its ability to provide engaging and customizable exercises makes it a valuable tool in addressing balance issues and reducing fall risks. however, it is essential to ensure that vr training is conducted under proper supervision to avoid potential accidents, especially in patients with severe copd or additional health concerns. overall, vr training represents a significant advancement in rehabilitation, offering a novel and effective approach to managing balance and fall risks in copd patients. the purpose of study is to determine whether vr training has significant effects on balance and fall risk of patients with copd (gold standard stage i \& ii).

Eligibility criteria:
inclusion criteria: * both male and female * diagnosed with mild to moderate copd (gold stages i-ii) * age between 40-65 years * bbs score above 35 will be included. * copd patients with oxygen saturation of above 88%. * patients able to follow instructions / commands. exclusion criteria: * recent exacerbation of copd requiring hospitalization within last 4 weeks. * diagnosed with severe cognitive impairments. * previous experience with vr-based rehabilitation. * use of medication that could affect exercise response.

Keywords: copd vr bbs
improving the quality of care for adults with inflammatory bowel disease

Conditions: Crohn's Disease; Ulcerative Colitis; Inflammatory Bowel Diseases

Summary: innovative programs exist that suggest that care for people with chronic conditions is optimized when patients and providers have the information they need at the point of care and over time, to engage in shared planning and execution of treatment goals and care plans. this project aims to build an inflammatory bowel disease learning health system, a shared information environment, that highlights collaboration among patients, clinicians and care team members, and researchers; for effective use of data for guiding care, value, improvement, and research.

to demonstrate the impact of an adult inflammatory bowel disease (ibd) learning health system approach the study collaborators will design, build, implement, and evaluate in up to 90 ibd care sites the the following four key components of the ibd learning health system: 1) a health information technology (hit) environment that can "feed-forward" patient reported outcomes (pros) and clinical data to be used at the point of care and integrated into a registry (ibd plexus); 2) decision-support dashboards for use by patients and clinicians in real time to coproduce care; 3) meaningful reports for patients and clinicians; and 4) multi-stakeholder collaborative networks for improvement and research. prior work from sweden and the us show that successful uptake of the model can offer important benefits. patients will be able to use web-based tools to monitor their health and manage their care, securely share data with clinicians in a timely manner, visualize outcomes that matter to them, and compare their results to other people. clinicians will have new information that can improve their ability to track patient outcomes and costs over time; use pro data to support pre-visit planning, shared decision-making at the point of care, and post-visit monitoring; and receive comparative performance reports to support quality improvement, public reporting, and professional development. researchers will benefit by having pros and cost data added to data registries to support clinical, translational, and comparative effectiveness research.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * diagnosis of crohn's disease or ulcerative colitis or ibd unclassified * accept the terms and conditions of informed consent and authorization * affiliated with a participating ibd qorus site exclusion criteria: * inability to provide informed consent * study key personnel cannot enroll as a study participant
relaxation response training for ptsd prevention in us military personnel

Conditions: Posttraumatic Stress Disorder

Summary: the purposes of this study are to evaluate the acceptability and utility of a mind-body intervention on a convenience sample of soldiers (n=120) who have screened positive through respect-mil for symptoms that may lead to post-traumatic stress and to test the effectiveness of this relaxation response (rr) intervention designed to decrease the physiological and psychosocial effects of stress and trauma. the study aims to enhance the psychological health of soldiers with a rr intervention designed to promote self-awareness of physiological responses to stress and the ability to increase relaxation responses.

specific aims: 1. demonstrate that trainers can be trained effectively to deliver the intervention, a mind-body skills training program based on the benson-henry institute's standard rr training curriculum and tailored to a military population. 2. evaluate feasibility, acceptability, and compliance to the training program in an active duty military population. 3. compare outcomes on sleep disturbance, ptsd, stress-related symptoms, quality of life, and psychosocial variables related to resilience of soldiers who receive the 6-week training program to promote the relaxation response to those soldiers who do not receive the intervention.

Eligibility criteria:
inclusion criteria: * 18 years or older, male and female volunteer individual military service members, dod civilians or approved contractors working for dod, primarily from multidisciplinary healthcare providers. * willingness to participate in the research project. * committed to the entire period of time of the research project. * currently working or stationed at ft bliss, texas. * no impending orders for deployment/ tdy/ pcs/ ets or retirement for at least 8 weeks from the day of study enrollment. * able to read and speak english. * capable to consent. exclusion criteria: • diagnosed with severe ptsd or other mental health issues disclosed as self-reported
dbt and escitalopram in borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: subjects will receive six months of dbt, consisting of one 90-minute group and one 60-minute individual session per week as well as telephone availability of the individual therapist. half the subjects will concurrently receive escitalopram while half will receive placebo, in a randomized double-blind design.


Eligibility criteria:
inclusion criteria: is a male or female between 18 and 60 who meets criteria for borderline personality disorder and has been off psychotropic medications for at least 2 weeks (6 weeks for fluoxetine). - exclusion criteria: meets criteria for schizophrenia, bipolar disorder, mental retardation, current or recent substance dependence or a current major depressive episode. subjects also should not currently be in individual psychotherapy. (case management and work therapy programs are allowed.) -

Keywords: borderline personality disorder bpd dialectical behavior therapy dbt escitalopram lexapro
depodur vs fentanyl infusion for post-c/s analgesia

Conditions: Analgesia

Summary: epidurally administered depodur provides equal or superior analgesia as an epidural infusion of fentanyl for the first 48 hours after a cesarean section.


Eligibility criteria:
inclusion criteria: * healthy pregnant women (asa i or ii) who are scheduled for an elective cesarean section * patient appropriate for regional anesthesia * patient agrees to receive regional anesthesia * patient willing to have an epidural infusion of medication for two days postoperatively exclusion criteria: * morbid obesity * history of sleep apnea * allergy to opioids medications * history of opioids use during week prior to procedure * emergency cesarean section * significant surgical complications * contraindication or refusal to have regional anesthesia * age less than 18

Keywords: analgesia cesarean section fentanyl depodur post-cesarean section analgesia
technology-enabled remote hypertension management to advance health equity

Conditions: Hypertension

Summary: the primary objective of this study is to reliably estimate the difference in blood pressure control of a technology-enabled solution for blood pressure (bp) management over usual care. the study will also assess patient and provider satisfaction with the solution. finally, the investigators will estimate the economic impact of the intervention in terms of resource utilization.

the study design is a non-blinded pragmatic cluster-randomized controlled trial with a single intervention. participants with uncontrolled hypertension will be identified from a randomly selected group of primary care clinics. participants from half of the clinics will be enrolled in the intervention arm while the others will receive usual care. participants in the intervention arm will undergo a series of software-driven medication initiation and titration steps until they reach a blood pressure target of systolic blood pressure \< 130 mmhg and diastolic blood pressure \< 80 mmhg. participants will be subsequently monitored for up to 12 more months.

Eligibility criteria:
inclusion criteria: * 18 years - 100 years * uncontrolled hypertension: as defined as sbp \> 140 or dbp \> 90 on 2 successive clinic visits exclusion criteria: * hearing impaired * visually impaired * cognitively impaired * hospice care * on hemodialysis at enrollment * new york heart association class iv heart failure