Kornimate/medical-research-clean huggingface dataset:
realizing opportunities for self empowerment

Conditions: Depression

Summary: the purpose of this study is to determine whether priority-based patient navigation will improve patient satisfaction, quality of life (qol), and depression when compared to screening-and-referral for socioeconomically disadvantaged women's health patients with depression. the investigators goal is to establish patient-driven, effective, generalizable, and disseminable interventions to reduce depression-related disparities and improve outcomes.

* in this comparative effectiveness study, 200 participants who are patients at the university of rochester women's health practice or highland woman's health and report significant depressive symptoms will be randomized to either psp (personal support for progress) or esr (enhanced screening and referral). participants assigned to psp will work with a patient navigator to prioritize their concerns, develop a personalized care plan, and implement their plan. participants assigned to esr will receive a personalized report of community resources that may be helpful for their identified needs. * the investigators will use a simple 1:1 randomized design with treatment assignment being conducted using a random number generator. all analyses will follow an intent-to-treat protocol, such that all participants randomized will be followed for data collection and analyzed according to her randomized condition * each participant will be assessed 4 times for outcome changes: at baseline, post treatment (4 months), and two follow up ( at 7 and 10 months). * assessments are self report on ipads and they are linked directly to a red cap database.

Eligibility criteria:
inclusion criteria: * diagnosed with depression (phq9 score 10 or higher) * patient of university of rochester women's health practice or highland women's health * monroe county resident * english speaking exclusion criteria: * currently receiving case management services * in need of acute psychiatric services * unable to commit to the duration of the project

Keywords: women depression socioeconomically disadvantaged navigation
hippotherapy versus swiss ball training to improve trunk control and balance on spastic daiplegic cerebral palsy

Conditions: Cerebral Palsy Spastic Diplegia

Summary: to compare effect in both intervention

in this study we will compare the effects of hippotherapy and swiss ball therapy. our objectives of the study are to compare the effects of hippotherapy and swiss ball training, to improve trunk control and balance on spastic diplegic cerebral palsy hypothesis: alternative hypothesis: there will be significant difference between the effects of hippotherapy and swiss ball training to improve trunk control and balance on spastic diplegic cerebral palsy null hypothesis: there will be no significant difference between the effects of hippotherapy and swiss ball training to improve trunk control and balance on spastic diplegic cerebral palsy. this study will include total 64 participants. calculated by open epitool.64patients will be divided in to 2 groups with equal sample size through sealed envelop method. group a will receive hippotherapy while group b will receive swiss ball therapy. group a intervention: the child is seat astride the horse wearing a helmet and was encouraged to perform various activities designed to emphasize movement in a forward and upward reaching and side to side direction to encourage active postural control, trunk strength, balance and trunk/pelvic dissociation.30 minutes with a frequency ranging from 4 sessions per week and the total duration of horseback riding 6 weeks .position the child to sit on the ball and giving forward, backward and side to side movement to the child. this will facilitate trunk rotation by which the upper body is towards the weight bearing hip and away from the weight bearing hip. training program 4 times per weeks with the treatment session of 30. group b intervention: position the child to sit on the ball and giving extension rotation and flexion rotation to the child. this will facilitate trunk rotation by which the upper body is towards the weight bearing hip and away from the weight bearing hip.training program 4 times per weeks with the treatment session of 30 minutes for 6 weeks duration minutes for 6 weeks duration. trunk control will be measured by three outcome measures which include trunk control measurement scale ,gross motor function scale and pediatric balance scale. intervention will be given for 6 weeks.assesment will be done on baseline, after 3 and 6 weeks.

Eligibility criteria:
inclusion criteria:• children (male and female) * age group 4 to 11 years * subject diagnosed with cp * mild spastic diaplegic of the lower limbs according to the modified ashworth scale grade 1 to 1+ * gmfm scale sitting balance score less than 20 * medically stable and able to understand commands exclusion criteria:• children with mental retardation, * epilepsy, other associated neurological disorders, other type of cerebral palsy, * attention deficit hyperactivity disorder and sensory issues(poor visual or hearing acuity)
x-ray evaluation of the effectiveness of the atlas correction in patients with chronic subluxation of the atlas

Conditions: Subluxation and Dislocation of C0/C1 Cervical Vertebrae

Summary: the aim of the study is to evaluate the effect of the procedure of medical acupressure of the suboccipital muscles according to the atlas-standard method on the normalization of the position of the first cervical vertebra and the angles of the spinal column in patients with diagnosed chronic subluxation with objectification of the results by radiography and inclinometry.


Eligibility criteria:
inclusion criteria: * patients with chronic subluxation of the first cervical vertebra with complaints of pain in the occiput/cervical/thoracic/lumbar spine/limitation of head rotation in one or both directions. * scoliotic deformity of the spine 1-2 degrees. exclusion criteria: * pregnancy * fractures of the first / second cervical vertebra in history * fractures of the spine in any of the departments in the anmenesis * assimilation of the atlas with the occipital bone or the second cervical vertebra * operations on the spine using metal structures * scoliosis 3-4 degree * botulinum toxin injections in the suboccipital region within the last year * taking muscle relaxants * corrective surgery on muscles and bones * braces * active period of dental implants installation * postoperative period (any operation, including on the eyes) less than 6 months * acute infectious diseases - less than 2 weeks from the start of recovery * skin diseases with inflammatory manifestations in the neck * oncological diseases * recovery period after injury (cervical and brain injury) or stroke less than a year * established mental illness * extreme malnutrition (cachexia)
does dietary nitrate supplementation improve aerobic performance

Conditions: Colorectal Cancer

Summary: the purpose of this study is to determine whether dietary nitrate supplementation improves performance in cardiopulmonary exercise testing (cpet).

dietary nitrate supplementation has been shown to enhance exercise tolerance and performance in professional athletes and physically active males. cardiopulmonary exercise testing (cpet) is an established, non invasive and safe method of assessing patients' cardiopulmonary reserve prior to surgery. it has been shown to predict complications and length of stay in patients undergoing major elective surgery. the anaerobic threshold (at), the oxygen uptake at which anaerobic atp synthesis supplements aerobic atp synthesis and the maximal oxygen uptake (vo2max) the point where the oxygen uptake plateaus despite an increase in work rate; both calculated during cpet; have both been shown to predict short and long term outcomes after surgery and postoperative complications. we aim to study the effect of dietary nitrate supplementation on cpet results in patients awaiting surgery for colorectal cancer. our primary outcome will be the change in the at and vo2max after beetroot juice supplementation. methods: patients will undergo an initial cpet and will then be randomized to receive either beetroot juice (brj, containing no3-, 6.2 mmol/day, administered as 500ml beet it sport shots, james white drinks, ipswich uk) or 'placebo' (pl, no3-depleted beetroot juice) for 7 days. a second cpet will then be performed. this pilot study will be used to calculate the mean at and vo2max and associated standard deviations for our population and the approximate effect of brj on them.

Eligibility criteria:
inclusion criteria: * elective colonic or rectal resection. exclusion criteria: * contraindication to cardiopulmonary exercise testing: unstable cardiac disease, lower limb dysfunction, inability to perform cpet * inability to give informed consent * emergency surgery * during cpet: ischemic ecg or inability to reach at * allergy to beetroot
weaning protocol for high-flow nasal oxygen therapy in intensive care

Conditions: Acute Hypoxemic Respiratory Failure; High-flow Nasal Oxygen Therapy

Summary: high-flow nasal oxygen therapy (hfno) is an oxygenation technique frequently used in intensive care. the main objective of our study is to show that the use of a protocol for weaning patients off high-flow nasal oxygen therapy (hfno) in the intensive care unit increases the probability that patients will be weaned from hfno at day 7 post-randomisation. this is a open-label multicentre randomised controlled trial conducted in two parallel groups. the primary endpoint is the success rate at day 7, with success defined as "definitive" weaning from hfno, i.e. patients weaned from hfno for more than 48 hours without recourse to non-invasive ventilation (niv) or intubation and still alive at day 7. the weaning protocol will be started as soon as the patient meets all the inclusion criteria, considered to be the prerequisites for initiating weaning from hfno. patients will be monitored until day 28 maximum.


Eligibility criteria:
inclusion criteria: * major patient admitted to the intensive care unit or continuous care unit for de novo hypoxaemic acute respiratory failure (with a pao2/fio2 ratio \<300 mmhg) * treated with hfno with a flow rate ≥ 50l/min and inspired oxygen fraction (fio2) ≥ 0.5, flow rate and fio2 having to be stable (i.e. not increased) in the 24 hours prior to inclusion * with a rox index (spo2/fio2/respiratory rate) stable or improving in the 6 hours prior to inclusion and greater than 4.88 * had a blood gas test under hfno within 24 hours of inclusion * participant covered by or entitled to social security * informed consent signed by the patient or its relatives if the patient is incapable; this consent must then be confirmed by the patient as soon as possible exclusion criteria: * presence of a patient included in the study and not weaned off hfno in the sector managed by the nurse of the patient assessed for eligibility * concomitant non-invasive ventilation treatment * use of hfno within 7 days of extubation * chronic obstructive pulmonary disease (gold grade 3 or 4) * cardiogenic acute pulmonary oedema as the main cause of acute respiratory failure * diffuse interstitial lung disease as a medical history * patient with long-term non-invasive ventilation with external positive pressure * patient on long-term oxygen therapy at home * pregnant women, women in labour and breastfeeding mothers * persons deprived of their liberty by a judicial or administrative decision, persons hospitalised without consent and persons admitted to a health or social establishment for purposes other than research. * minor * adult subject to a legal protection measure (guardianship, curators, person under court protection) * patient with a medical decision not to intubate * patients already included in the study, neither for the same stay if they were to present the inclusion criteria again, nor for subsequent stays
liver cancer hepasphere combined with cryosurgery

Conditions: Liver Cancer

Summary: the purpose of this study is to evaluate the safety and efficacy of hepasphere interventional therapy using digital subtraction angiography（dsa）combined with cryosurgery for liver cancer.

by enrolling patients with liver cancer adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of hepasphere interventional therapy using digital subtraction angiography（dsa） combined with cryosurgery for liver cancer.

Eligibility criteria:
inclusion criteria: 1. age:18-80 2. karnofsky performance status \>60 3. diagnosis of pancreatic cancer based on histology or the current accepted radiological measures. 4. classification tumor,nodes,metastasis-classification(tnm) stage: ⅱ,ⅲ,ⅳ 5. will receive interventional therapy 6. life expectancy: greater than 3 months 7. patients' routine blood test, liver function and kidney function have no obvious abnormalities 8. ability to understand the study protocol and a willingness to sign a written informed consent document exclusion criteria: 1. patients with other primary tumor except liver cancer 2. history of coagulation disorders or anemia

Keywords: liver cancer hepasphere cryosurgery
impact of patient reported outcomes for pre-chemotherapy medical decision in day patients with digestive cancer

Conditions: Digestive Cancer

Summary: the investigators hypothesize that an early assessment of the clinical toxicity of the patient is possible via patient reported outcomes and that this information provides at least the same information level as the clinical examination of the patient made by the doctor. the early decision to prepare chemotherapy medications based on the indirect early collection of clinical information from the patient via a patient reported outcome should help minimize the number of chemotherapy medications destroyed.


Eligibility criteria:
inclusion criteria: * the patient must have given their free and informed consent and signed the consent form * the patient must be a member or beneficiary of a health insurance plan * patient is undergoing at least their second chemotherapy regime (outside weekly scheme or protocol with cisplatin requiring hospitalization) for a digestive tumor * patient has a smartphone or access to the internet (via tablet or computer) * the patient is under consultation as a day patient in the oncology department of nimes hosptial exclusion criteria: * the subject is participating in a category 1 interventional study, or is in a period of exclusion determined by a previous study * the subject refuses to sign the consent * it is impossible to give the subject informed information * the patient is under safeguard of justice or state guardianship * the patient is pregnant, parturient or breastfeeding * patient has already participated in the study * patient undergoing first chemotherapy regime
suture-closure omentopexy versus omentopexy alone in repair of perforated peptic ulcer

Conditions: Perforated Peptic Ulcer

Summary: the present study will be conducted to assess whether there is a direct benefit associated with modified-graham's omentopexy (mgo), above and beyond the benefit associated with graham's omentopexy (go) in the treatment of perforated duodenal ulcers. we attempted to answer the question whether primary closure of the perforation in mgo will affect the outcome of surgery. complication rates will be compared for the two alternative surgical procedures.


Eligibility criteria:
inclusion criteria: - all adult patients of both sexes with a clinical diagnosis of perforated peptic ulcer (gastric or duodenal) that are fit to undergo surgery. exclusion criteria: - 1. patients with associated bleeding ulcer (additional steps are needed to control bleeding). 2. patients with associated pathology other than perforated peptic ulcer that needs surgical intervention.
opinion of brazilian gynecologists on hormone therapy for menopause and prescriptive habits

Conditions: Menopause; Opinions; Hormone Replacement Therapy

Summary: to evaluate brazilian gynecologists, through structured online questionnaires, with questions directed to their opinions and prescriptive habits about menopause hormone therapy. research participants will complete the questionnaires in digital format online.

there are few brazilian population studies on the opinion of brazilian gynecologists about the hormonal therapy of menopause in climacteric women, their prescriptive habits and their views on the availability of treatments offered, demanding better evaluation and justifying efforts to analyze the perception of professionals in this area in our country. methods: to assess gynecologists across the country, through structured online questionnaires, with questions aimed at knowing their opinions and prescriptive habits about menopause hormone therapy. research participants will complete the questionnaires in digital format online. doctors will be invited to participate by e-mail messages and by social media.

Eligibility criteria:
inclusion criteria: * brazilian licensed gynecologist doctors exclusion criteria: * retired doctors * health professionals other than medicine doctor * medical specialties other than gynecology * medical employees of the pharmaceutical industry
testing brief personalized feedback integrating lab-based alcohol cue information

Conditions: Alcohol Consumption

Summary: this study aims to develop a brief intervention that uses information from a lab-based cue reactivity protocol to create personalized feedback targeting high-risk alcohol use among young adults who drink alcohol. the intervention provides feedback on individuals' drinking desire, mood, willingness to drink, and alcohol demand by comparing scores before and after viewing and smelling an alcoholic beverage in the lab session. other psycho-educational alcohol-related content is also provided in the intervention including strategies for decreasing exposure to cues that increase drinking desires and how to cope with increased desire to drink. this brief intervention is used in a randomized controlled trial (rct) comparing young adults who receive the brief, online intervention to those who did not receive the brief, online intervention. participants in both groups complete baseline, lab-based cue reactivity protocol, 2-week follow-up and 3-month follow-up.

the purpose of this study is to develop and test a brief intervention that provides personalized feedback to young adults using participants' responses from a baseline survey and from a lab-based cue reactivity protocol. the aim of the intervention is to increase young adults' awareness of how alcohol cues may affect their desire to drink, mood, willingness to drink, and alcohol demand both in relation to lab-based exposure to an alcohol beverage of their choice and also more broadly in everyday life. the intervention also aims to equip young adults with strategies for reducing exposure to factors that increase their desire to drink, how to cope with an increased desire to drink, and how to reduce potential harms from drinking. this brief personalized feedback intervention is used in a randomized controlled trial comparing young adults who receive the intervention with those who complete the assessments and lab protocol but do not receive any personalized feedback. online assessments include an eligibility survey, baseline assessment, and follow-up assessments occurring 2-weeks and 3-months post-intervention. everyone has one in-person session to complete the lab-based cue reactivity protocol after the baseline assessment has been completed online. the intervention will be examined for its feasibility, acceptability, and its effects in reducing alcohol-related outcomes at the follow-up assessments.

Eligibility criteria:
inclusion criteria: * between ages 18-24 * lives in washington state * reports drinking at least two days per week in the last six months * reports at least one heavy drinking episode (4+/5+ drinks for women/men) in the past month * open to changing drinking behavior * must be willing to come to our seattle study office for session visit * provide an email address and phone number for study communication exclusion criteria: * actively seeking treatment for alcohol use * currently participating in another study in our research center regarding young adult drinking behavior
persistent weight maintenance for 6 months after 3 months of active weight loss

Conditions: Weight Reduction

Summary: this study is intended to report changes in the weight and metabolic indicators of the subjects six months after the end of the study for adults with a risk factor of 27 kg/m2 or higher (formerly the research task name\[clinicaltrial.gov;nct03675191\]).

there was no special intervention after the previous research intervention. after the previous research was completed, we will check the changes in the body composition and metabolic indicators over six months.

Eligibility criteria:
inclusion criteria: * those who have participated in the previous trial (nct03675191) and have completed the three-month study * those who agreed the trial. exclusion criteria: * those who have withdrawn the previous trial (nct03675191)
a clinical trial to assess the efficacy of a plant-based energy shot on focus and adhd-like symptoms

Conditions: ADHD; Attention Difficulties; Mood; Anxiety; Caffeine

Summary: this is a virtual, single-arm clinical trial that will last 28 days. participants will drink 1 bottle of proper wild energy shot daily and complete questionnaires at baseline, day 1, day 14, and day 28. attention deficit hyperactivity disorder (adhd)-like symptoms, such as concentration, focus, and attention, will be evaluated at baseline and at each check-in. likert scale responses will be examined from baseline to each check-in. participant responses on product feedback will be presented as % scores.


Eligibility criteria:
inclusion criteria: * currently experiencing symptoms associated with adhd, including: impulsiveness. disorganization and problems prioritizing poor time management skills problems focusing on a task trouble multitasking excessive activity or restlessness poor planning * age 18-55 * self-reported issues with focus and/or productivity * generally healthy - don't live with any uncontrolled chronic disease exclusion criteria: * currently taking prescription medication for adhd * currently supplementing with l-theanine. * known to respond negatively to caffeine (no effect, makes them sleepy or feel unwell) * people with a high caffeine tolerance defined as regular consumption of \>400mg of caffeine (\>4 coffees) per day. * any pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders. * anyone with known severe allergic reactions. * women who are pregnant, breastfeeding, or attempting to become pregnant * unwilling to follow the study protocol.