Kornimate/medical-research-clean huggingface dataset:
intraoperative warming during major surgical procedures using the esophageal temperature management system

Conditions: Hypothermia Following Anesthesia; Hypothermia; Surgery

Summary: the aim of this study is to assess the effectiveness of ensoetm as a supplemental warming device compared to the standard of care warming practice in patients having major surgery.

maintaining patient's body temperature is of major importance in patients undergoing surgical procedures and existing methods to warm patients to maintain perioperative normothermia have limitations. this results in as many as half of patients undergoing surgery developing inadvertent hypothermia during and/or after their procedure. the ensoetm is an esophageal temperature management (etm) device consisting of a multi-chambered silicone tube connected to a heat exchanger and placed in the esophagus, providing highly efficient heat transfer to a patient. the ensoetm potentially improves the ability to control patient temperature by eliminating the disadvantages of existing methods while maintaining the functionality of the orogastric tube that it replaces. the primary objective of this study is to measure the number of degree-hours spent below 37°c intraoperatively and until recovery in the pacu. this measure will be compared between patients having standard management of body temperature to patients having the ensoetm placed as an additional warming device.

Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form * male or female, ages 18 years and older * scheduled for major surgical procedures requiring general anesthesia and with no known contraindication to having an orogastric tube placed for the duration of the surgery * the time in the or is expected to last at least 180 minutes exclusion criteria: * esophageal strictures (risk of perforation) * patients with known esophageal deformity or evidence of esophageal trauma (for example history of esophagectomy, previous swallowing disorders, achalasia, etc.) * known ingestion of acidic or caustic poisons within the prior 24 hours. * patients with \<40 kg of body mass * coagulopathy * severe facial trauma * surgical procedures lasting less than 3 hours

Keywords: intraoperative hypothermia inadvertent hypothermia perioperative hypothermia
sbrt for oligometastatic castration-refractory prostate cancer

Conditions: Prostate Cancer

Summary: castration-resistant prostate cancer patients with rising prostatic specific antigen (psa) are eligible for this study. 11c-choline pet/ct will be used to identify metastatic lesions. patients with \<=3 metastatic lesions will receive stereotactic body radiotherapy (sbrt) as definitive treatment. blood draws will be taken to monitor the development of anti-prostate cancer immunity


Eligibility criteria:
inclusion criteria: * patients must be receiving standard of care sbrt as outlined in the universal content management (ucm) procedure manual (http://mayocontent.mayo.edu/radoncology/categories/index.html) * age ≥ 18 years. * metastatic castration-refractory prostate cancer patients with ≤ 3 lesions identified on standard imaging and/or choline pet/ct within 60 days of registration * castrate levels of testosterone * eastern cooperative oncology group (ecog) performance status (ps) ≤ 2 (appendix i). * life expectancy \> 6 months exclusion criteria: emergent cord compression for spinal metastases * severe, active co-morbidity, defined as follows: 1. unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months prior to registration 2. transmural myocardial infarction within the last 6 months prior to registration 3. acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration 4. chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days prior to registration 5. severe hepatic disease, defined as a diagnosis of child-pugh class b or c hepatic disease. 6. hiv positive with cluster differentiation 4 (cd4) count \< 200 cells/microliter. note that patients who are hiv positive are eligible, provided they are under treatment with highly active antiretroviral therapy (haart) and have a cd4 count ≥ 200 cells/microliter within 30 days prior to registration. note also that hiv testing is not required for eligibility for this protocol. 7. end-stage renal disease (i.e., on dialysis or dialysis has been recommended). * metastases located within 3 cm of the previously irradiated structures: 1. spinal cord previously irradiated to \> 40 gy 2. brachial plexus previously irradiated to \> 50 gy 3. small intestine, large intestine, or stomach previously irradiated to \> 45 gy 4. brainstem previously irradiated to \> 50 gy 5. lung previously irradiated with prior v20gy \> 30%
preoperative chewing gum and postoperative nausea and vomiting

Conditions: Gynecologic Disease

Summary: general anesthesia for surgery can often lead to postoperative nausea and vomiting (ponv). additionally, decreased or paralyzed bowel movements are among the most common complications following abdominal surgery, causing pain, abdominal distension, nausea, and vomiting, which can delay patient recovery and extend hospital stays. therefore, meticulous perioperative management is crucial. in recent years, efforts have been made to reduce the burden of surgery, decrease postoperative complications, and promote rapid rehabilitation for a quicker return to daily life. these efforts also aim to reduce healthcare costs by shortening hospital stays and optimizing resources. various interventions, such as early feeding, early removal of nasogastric tubes, and physical therapy, have been trialed in clinical settings to prevent prolonged bowel inactivity and paralysis. however, due to limited clinical efficacy, these methods are not routinely used. recently, many researchers have reported the benefits of chewing gum in enhancing bowel motility and reducing ponv. however, there is limited research on the impact of chewing gum on ponv in robotic surgeries, which are considered less invasive compared to open or laparoscopic surgeries. furthermore, there is particularly scarce research on the effects of preoperative gum chewing.


Eligibility criteria:
inclusion criteria: 1. adult patients aged 19 to under 70 years 2. scheduled elective robotic surgery 3. american society of anesthesiologists (asa) physical status classification i or ii exclusion criteria: 1. cases where robotic surgery was planned but suddenly converted to another type of surgery 2. patients with a history of dental damage, dentures, loose or capped teeth, or other unstable dental conditions 3. patients with a history of temporomandibular joint (tmj) damage or surgery 4. head and neck surgeries 5. emergency surgeries 6. refusal to participate in the study
effect of protaper ultimate system on post-endodontic pain

Conditions: Post Endodontic Pain

Summary: this clinical trial aims to compare the effect of pro taper ultimate and pro taper gold files on post-endodontic pain in molars with symptomatic apical periodontitis. the main question it aims to answer is: if there is a difference in post-endodontic pain intensity following root canal preparation using pro taper ultimate and pro taper gold files in molar diagnosed with symptomatic apical periodontitis? participants will undergo root canal treatment using pro taper ultimate and pro taper gold files. researchers will compare \[pro taper ultimate and pro taper gold files\] to see the intensity of post-endodontic pain

the study will be conducted on 40 first mandibular molars; with 20 first mandibular molars in each group (n=20). the patient will be asked to pick an opaque sealed envelope that will contain a number from 1 to 2. the resultant number will determine in which group the participants will be placed. group i: root canal preparation using pro taper ultimate. group ii: root canal preparation using pro taper gold. procedural steps: 1. vitality will be assessed using cold tests and electric pulp testing before the procedure is carried out. besides, mobility, palpation, and percussion tests will be done to assess periapical health. in order to ensure that the cold and electrical pulp tests are working, and a response is elicited, both tests will be carried out on patients not included in the study. 2. all the patients will receive local anesthesia: 2% lidocaine with 1:100,000 epinephrine. 3. each tooth will be isolated using a rubber dam, and the access cavity will be prepared using a round bur (no.4) and tapered fissure diamond bur under copious water. 4. after removal of coronal pulp tissues using a sterile excavator, the working length will be determined with stainless steel hand k-files size #10 and the use of an apex locator and confirmed using intraoral periapical radiographs. 5. hand instrumentation to 15-size k files. 6. group i will be prepared using protaper ultimate files. 7. group ii will be prepared using protaper gold files. 8. apical patency will be maintained throughout the shaping procedure using the #10 file between each instrument. 9. all the canals will be irrigated with 10 ml of 3% naocl between each file during the whole preparation procedure. 10. all the root canals will be obturated directly after preparation. 11. all the teeth will be restored using resin composite restoration.

Eligibility criteria:
inclusion criteria: * patient was diagnosed with symptomatic irreversible pulpits and symptomatic apical periodontitis. * 18-70 years old patients * permanent mandibular first molars. * teeth with a fully matured root. * restorable teeth indicated for endodontic treatment. * healthy patients. exclusion criteria: * complex root canal morphology * calcified roots. * teeth with internal and external resorption. * medically compromised patients. * restricted mouth openings (trismus).

Keywords: post endodontic pain protaper gold protaper ultimate root canal preparation
the effect of transcranial direct current stimulation (tdcs) on depression in pd

Conditions: Parkinson's Disease

Summary: depression is common in parkinson's disease (pd), but the effective treatment is not established yet. tdcs is a non-invasive brain stimulation to modulate brain function. the tdcs on the depression in general population were already conducted, but not in pd. this study is to know whether transcranial direct current stimulation (tdcs) is effective for the treatment of depression in pd. participant will be asked to visit three consecutive days for the non-invasive stimulation.


Eligibility criteria:
inclusion criteria: * uk parkinson's disease brain bank criteria * more than 19 years old * able to provide consent for the protocol * depression (based on dsm-iv criteria) exclusion criteria: * dementia * unpredictable symptom fluctuations * contraindication to tdcs (i) irritations, cuts, lesions in the brain (ii) any preexisting unstable medical conditions, or conditions that may increase the risk of stimulation such as uncontrolled epilepsy (iii) history of severe cranial trauma with alteration of the cranial anatomy or metallic intracranial implants (iv) history of seizure * subjects without the capacity to give informed consent * if participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as excessive fatigue, general frailty, or excessive apprehension
non-invasive ventilation and oxygen therapy in cystic fibrosis patients with nocturnal oxygen desaturation

Conditions: Cystic Fibrosis

Summary: the purpose of this study is to determine whether correction of low nighttime oxygen (o2) levels and/ or high carbon dioxide levels in patients with cystic fibrosis improves their quality of life. the treatments being used overnight are (1)o2 (2)pressurised air which assists breathing (non-invasive positive pressure ventilation, nippv)

cystic fibrosis is the commonest life-limiting genetic disorder in the caucasian population with a median survival of 31 years. lung disease is responsible for the majority of morbidity and mortality and correlates with declining quality of life. respiratory failure is the primary cause of death. daytime respiratory failure (hypoxia with po2\ 50) is associated with a worse prognosis with a 2-year survival of 50%. nocturnal respiratory failure (greater than 5% of the night spent with spo2\ 10mmhg overnight) is a precursor to the development of daytime respiratory failure. it has been postulated that earlier treatment of respiratory failure may improve outcome and quality of life. intervention: nocturnal o2 and bilevel nippv in cf patients with nocturnal respiratory failure, compared to nocturnal placebo (air). crossover trial utilising patients as their own control. aims: (1) to assess the effects of non-invasive ventilation (niv) and oxygen (o2) therapy on quality of life, hospital admission rate, sleep quality and exercise tolerance in cf patients with nrf (2) to identify a level of severity of nrf where treatment with niv is effective

Eligibility criteria:
inclusion criteria: proven diagnosis cystic fibrosis, age 18 years or older, fev1\ 10% of night or rise in ptcco2 \> 5 mmhg in rem), daytime hypercapnia (paco2\> 45 mmhg) exclusion criteria: previous home o2 or niv use, sedative medications, cardiac/renal/endocrine/neurological disease likely to compromise ventilatory control

Keywords: cystic fibrosis hypoxia oxygen noninvasive ventilation quality of life
nephrocalcinosis in very low birth weight infants

Conditions: Infant; Premature, Light-For-Dates

Summary: extremely premature children benefit from specific follow-up that requires high nutritional intake and the use of specific therapies that expose them to the risk of nephrocalcinosis. other identified risk factors are extreme prematurity and intrauterine growth restriction. the incidence of nephrocalcinosis in very premature infants is unclear, ranging from 7 to 64%. most studies are observational and only few case-control studies can properly analyse the risk factors for nephrocalcinosis in significant populations that include only preterm infants. this nephrocalcinosis of prematurity regresses spontaneously in more than half of the cases, but has been associated with a risk of long-term complications: impaired renal function, high blood pressure, etc. this is an aggravating factor in the context of prematurity, which has been associated with an increased risk of renal impairment and hypertension in childhood and adulthood. for all these reasons, nutritional intakes and therapeutics are monitored very closely and a renal ultrasound is routinely performed at discharge at 35 weeks of corrected gestational age in all children who are born at a gestational age ≤ 32 weeks and/or birth weight ≤ 1500 g.


Eligibility criteria:
inclusion criteria: * newborns with a gestational age \<= 32 weeks and/or birthweight \<=1500g exclusion criteria: * newborns with kidney malformation
correct study of minimal residual disease detection in colorectal cancer

Conditions: Colorectal Cancer

Summary: the correct - mrd ii study will prospectively enroll patients who have undergone complete surgical resection for stage ii or iii colorectal cancer. patients will be followed for a minimum of 3 years and up to 5 years for recurrence.


Eligibility criteria:
inclusion criteria: 1. diagnosis of carcinoma of the colon or rectum (patients with lymphomatous, sarcomatous, or neuroendocrine features are not eligible). 2. post complete surgical resection of crc, with last surgery occurring within 180 days prior to enrollment are eligible if all of the following conditions are met: 1. in the opinion of the surgeon, all grossly visible tumor was completely resected ("curative resection") and 2. histologic evaluation by the pathologist confirms the margins of the resected specimens are not involved by malignant cells. i. patients with t4 tumors that have involved an adjacent structure (e.g., bladder, small intestine, ovary, etc.) by direct extension from the primary tumor must have had all or a portion of the adjacent structure removed en bloc with the primary tumor and local radiation therapy will not be utilized. 3. pathologic stage ii or iii 4. ecog performance status ≤ 2 (0, 1 or 2). 5. able to understand and provide written informed consent. 6. willing and able to comply with the study requirements, which includes the collection of approximately 43ml of blood for each research blood draw. exclusion criteria: 1. initiated adjuvant therapy for current crc diagnosis (note: prior neoadjuvant therapy acceptable). 2. pregnant or breastfeeding at time of enrollment. 3. prior history of any invasive cancer (including crc) within the past 3 years prior to informed consent, with the exception of non-melanoma skin cancer. patients with a prior history of noninvasive (in situ) carcinomas may participate after definitive treatment. 4. prior transplant history: 1. prior allogeneic hematopoietic stem cell transplant at any time. 2. prior solid organ transplant within the last 2 years prior to enrollment. 5. multiple cancer diagnoses: synchronous or asynchronous diagnoses (or suspicion) of multiple primary cancers at the time of eligibility screening.

Keywords: colorectal ctdna
identification of genetic polymorphisms related to propofol requirement and recovery through genome-wide association study (gwas) in total intravenous anesthesia for clipping of unruptured cerebral aneurysm in korean population

Conditions: Unruptured Cerebral Aneurysm

Summary: in neurosurgical anesthesia, propofol based total intravenous anesthesia (tiva) is frequently used due to brain relaxation and less effect on electrophysiologic monitoring. response to propofol can vary between individuals and be associated with clinical factors including age and weight, and genetic polymorphism. because the importance of rapid recovery in neurosurgery with long operation time is emphasized recently, the choice and dose adjustment of anesthetics should be determined according to clinical and genetic factors. recently, researches about genetic variations have been performed with single nucleotide polymorphism (snp). the aim of this study is to find snps associated with propofol recovery and response through genome-wide association study (gwas) in korean adult population undergoing propofol based tiva for clipping of unruptured cerebral aneurysm.


Eligibility criteria:
inclusion criteria: * korean adult population undergoing propofol based tiva for clipping of unruptured cerebral aneurysm exclusion criteria: * patients not able to read, or understand the consent form * ethnicity, other than korean population * patients refusal * patients not to perform total intravenous anesthesia * patients currently taking psychiatric medication
assessing uniqueness of inflammatory bowel disease related microbiome-derived biomarkers

Conditions: Irritable Bowel Disease

Summary: to assess the differential expression of ibd-related microbiome-derived biomarkers including bacterial strains and peptides such as antimicrobial peptides (amp) found in inner-colonic samples (hygisample™) in comparison to home collected stool samples in patients with active ibd colonic disease. the hygisample will be collected during a defecation-inducing high-volume (\>40 l) colon irrigation bowel prep (hygiprepⓡ).

this study is a preliminary study aimed to assess the ability to differentially detect ibd-related microbiome-derived biomarkers in colon effluent samples collected using the hygieacare system. the proposed sample size of 20 patients (10 in the control arm, 10 in the ibd arm), where each patient provides both stool and three inner-colonic samples is sufficient to provide preliminary results for such an assessment. categorical variables will be summarized by frequencies and percentages, while quantitative variables will be summarized by descriptive statistics (mean, median, standard deviation, minimum, and maximum). the investigators will compare taxonomy and phylogeny biodiversity between the control and the ibd arms and between stool and colon effluent samples.

Eligibility criteria:
inclusion criteria: * the patient's age is between 18 and 80 years old * for study arm - patients with known colonic ibd based on colonoscopic findings - diagnosed with either ulcerative colitis or crohn's disease scheduled for surveillance colonoscopy. * for control arm - patients scheduled for routine colonoscopy without active ibd symptoms or ibd diagnosis exclusion criteria: * the patient has an underlying condition that in the opinion of the investigator may adversely affect the patient's ability to understand, comply with, or follow protocol instructions * history of intestinal resection (appendectomy allowed) * active clostridium difficile colitis * antibiotic use for 2 months prior to colonoscopy * the patient has any of the contraindications listed below: congestive heart failure, intestinal perforation, carcinoma of the rectum, fissures or fistula, severe hemorrhoids, abdominal hernia, renal insufficiency, cirrhosis, pregnancy, or recent colon, rectal, or abdominal surgery
mitral regurgitation risk assessment and clinical modelling

Conditions: Mitral Insufficiency; Mitral Regurgitation (MR)

Summary: mitral regurgitation (mr) is a common valvular heart disease worldwide, and untreated severe mr is associated with an elevated risk of heart failure and mortality. according to causes, mr could be divided into primary or secondary mr. the risk factors of mortality or heart failure hospitalization in different types of mr patients are under intensive investigation. mitral regurgitation risk assessment and clinical modelling (miracle) study is a prospective cohort study including adult patients diagnosed with ≥ moderate mr during hospitalization. we aim to evaluate the prognostic risk factors of patients with mr and construct a prognostic clinical model to guide clinical decision-making.


Eligibility criteria:
inclusion criteria: * patients diagnosed with ≥ moderate mitral regurgitation during hospitalization. * aged over 18 yrs. exclusion criteria: * patients unable to provide written consent.

Keywords: mitral regurgitation all-cause mortality clinical modelling cardiovascular mortality heart failure hospitalization
effect of exercise training on angiogenesis and cachexia in lung cancer patients

Conditions: Non-small-cell Lung Cancer

Summary: cancer is one of the leading health issues in this country and worldwide. angiogenesis is an essential process for tumoral growth and metastasis. this process is dependent on the balance between angiogenic factors and antiangiogenic factors. muscle wasting has been associated with myostatin overexpression in cancer. exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. the purpose of this study is mainly to investigate the effects of exercise training on 1. circulating vegf-a 2. muscle growth and function 3. myostatin


Eligibility criteria:
inclusion criteria: * age 40-75 years * advanced nsclc * eastern cooperative oncology group performance status of 0 or 1 * targeted therapy for at least 8 weeks * stable condition exclusion criteria: * severe metastasis, cardiopulmonary or musculoskeletal conditions may affect participation in exercise * do not understand the verbal or written instructions

Keywords: tumor angiogenesis exercise training vegf myostatin