Kornimate/medical-research-clean huggingface dataset:
implementation of smoking cessation within nci community oncology research program (ncorp) sites

Conditions: Smoking Cessation

Summary: evaluate a multi-faceted training program to improve short-term smoking cessation rates (\<14 days post-visit) and short (3 months) and sustained abstinence (6 months) among 1,114 enrolled smokers who present for low-dose computed tomography (ldct) lung cancer screening in 26 community-based practices.

we utilize an effectiveness-implementation hybrid design, employing a cluster, randomized control trial of community-based ncorp sites to study the effectiveness of a multi-faceted intervention to improve smoking cessation among lung cancer screening patients, as well as dissemination and implementation (d\&i) science to optimize and accelerate translation of findings into clinical practice. we will: (1) evaluate a multi-faceted training program to improve short-term smoking cessation rates (1-week post-visit) and sustained abstinence (6 months) among 1,114 enrolled smokers (557 in each trial arm) who present for ldct lung cancer screening in community-based lung cancer screening practices; (2) characterize the adoption and adaptation of the evidence-based tobacco cessation strategies in 26 community-based ldct lung cancer screening programs; and (3) develop and evaluate an implementation toolkit for integrating evidence-based tobacco cessation strategies in community-based ldct lung cancer screening programs. qualitative data will be collected from key informants at participating screening programs during and after intervention implementation. quantitative survey data (baseline, \<14 days, 3 months, and 6 months) and saliva specimens (6 months only) will be collected from smoking patients receiving screening within these programs.

Eligibility criteria:
inclusion criteria: * agrees to have ncorp research personnel serve as the study liaison and another person to serve as the cessation program champion. * agrees to participate in all aspects of the intervention, randomization, and evaluation. * agrees to participate in a confidential 1-on-1 semi-structured interview with the research team. * agrees to have the interview taped, transcribed and qualitatively analyzed. * age ≥18 years * potential participants will be screened using the following question: "do you smoke cigarettes every day, some days, or not at all?" (brfss). a current smoker is anyone responds "every day" or "some days". exclusion criteria: * current use (previous 30 days) of a tobacco dependence treatment including bupropion, varenicline, and nicotine replacement * individuals who use e-cigarettes and who are not smoking cigarettes. dual users (those who use both e-cigarettes and cigarettes) will still be included in the trial. * the presence of a physical or cognitive impairment that would prevent a person from engaging in survey research (such as blindness, deafness, or dementia). * individual has already completed the intended ldct lung cancer screening for this study. * non-english speaking participants.

Keywords: lung cancer cancer screening tobacco use
the effect of repetitive standardized patient simulation and end of life care education on nursing students' knowledge attitudes and moods

Conditions: End of Life Care

Summary: this research is a randomized experimental intervention study designed to examine the effect of repetitive standard patient-based education given to nursing students with end-of-life care education nursing on the level of knowledge, attitudes, and moods of the patient's care during the death process.

the research sample of the study consisted of fourth-year nursing students who agreed to participate in the study (n=50). in the study, an end-of-life care nursing education program was applied to all students. in the second stage, the standard patient-based practice was performed once with the control group nursing students and twice with the intervention group students. in data collection, an end-of-life care nursing questionnaire, frommelt attitude scale, positive-negative affect scale, and modified simulation effectiveness tool were used.

Eligibility criteria:
inclusion criteria: * not having a course in which a four-year undergraduate education is unsuccessful, * not participating in the pilot study of the research * to voluntarily agree to participate in the research. * being a fourth-year student in the department of nursing exclusion criteria: * participating in the pilot study of the research * wanting to leave the research. * being a first, second and third-year student in the department of nursing

Keywords: end of life care standardized patient nursing attitude emotion
mechanical thrombectomy in the middle east and north africa: interim results from the memento registry

Conditions: Stroke; Stroke Acute; Endovascular Procedures; Large Vessel Occlusion

Summary: the memento (mechanical thrmobectomy network for mena together) registry is a multicenter, prospective observational study aiming to evaluate the effectiveness, safety, and cost-effectiveness of mechanical thrombectomy (mt) in patients with acute ischemic stroke (ais) due to large vessel occlusions (lvo) in the middle east and north africa (mena) region. this interim analysis reports on the first 499 patients enrolled, assessing clinical outcomes, procedural details, and economic implications.

detailed description stroke is a leading cause of morbidity and mortality worldwide, with a significant burden in the mena region due to limited access to advanced stroke care therapies like mechanical thrombectomy (mt). the memento registry seeks to collect real-world data on mt practices, outcomes, and accessibility in the mena region to inform clinical practice and policy. the study includes ais patients who underwent mt for confirmed lvo or medium vessel occlusion (mevo), with or without prior intravenous thrombolysis (iv tpa), regardless of age, baseline nihss score, or time from symptom onset. data collected encompass demographics, clinical characteristics, imaging findings, procedural details, outcomes at discharge and follow-up, complications, and a cost-effectiveness analysis comparing mt to standard medical care (smc). the primary outcome is functional independence at 90 days post-procedure, defined as a modified rankin scale (mrs) score of 0-2.

Eligibility criteria:
inclusion criteria: adults aged 18 years and older (no upper age limit). diagnosed with acute ischemic stroke due to confirmed large vessel occlusion (lvo) or medium vessel occlusion (mevo). underwent mechanical thrombectomy (mt) with or without prior intravenous thrombolysis (iv tpa). pre-stroke modified rankin scale (mrs) score of 0-5. consent to participate in the registry (by patient or legal representative). exclusion criteria: absence of confirmed lvo or mevo. pre-stroke mrs score of 6. known severe comorbid conditions precluding mt. inability to obtain informed consent. patients not treated with mt.

Keywords: mechanical thrombectomy acute ischemic stroke large vessel occlusion middle east and north africa mena region endovascular treatment cerebral infarction brain ischemia stroke management reperfusion therapy neurointervention cerebrovascular
reliability of ultrasound metrics used in hip dysplasia diagnostics - a prospective study

Conditions: Developmental Dysplasia of the Hip

Summary: several measurements are used to evaluate hip dysplasia in hip ultrasound of children. despite having being used since the 1980s, reliability studies have failed to find acceptable reliaiblity values for the gold standard ultrasound methods. this study will evaluate three ultrasound measurement methodologies in a high quality controlled setting, to investigate the best achieveable reliability and agreement of the investigated measurements used in hip dysplasia diagnostics.

in ddh diagnostics, measurements of acetabular alpha angles and femoral head coverages (fhc), developed by graf and harcke/terjesen respectively, have been gold standard since the 1980s. despite their widespread use, the reliability of these measurements has been questioned due to the relative complexity of acquiring the necessary coridrect frontal 2d plane or "standard plane". in the only meta-analysis of the reliability of ultrasound (us) metrics in dysplasia, the interrater reliability of the alpha angles was mediocre while the reliability of the fhc was poor. critics of these findings however argue that the low reliability reported in studies are due to misinterpretation and misapplication of the graf method. the pubo-femoral distance (pfd) was proposed in 2013 as a new measurement for assessing ddh, while the reliability is reportedly higher than the gold standard us methods, it has never been directly compared to these. this study aims to evaluate the inter- and intrarater reliability of graf's alpha and beta angles, the fhc and pfd in children referred for hip us in a selective ultrasound screening program for ddh.

Eligibility criteria:
inclusion criteria: * children referred to the radiological outpatient at auh for hip ultrasound examination, suspect of ddh. * children receiving follow-up ultrasound for previously diagnosed ddh exclusion criteria: * children deemed too agitated to participate in hip us with double measurements by two radiologists.
effect of thermomechanical stimulation device and virtual reality glasses during peripheral intravenous catheterization

Conditions: Catheterization

Summary: the study was conducted as a randomized controlled experimental study to determine the effect of thermomechanical stimulation device (buzzy®) and virtual reality goggles (vrg) applied during peripheral intravenous catheterization (pic) on pain and patient satisfaction in adult patients.

the research was carried out at the emergency department of the etimesgut şehit sait ertürk state hospital in ankara from april 2021 to february 2022. the sample of the study consisted of 126 adult patients. the patients were divided into three groups by randomization method. vrg was applied to the first group, buzzy to the second group and the control group which was the third group using the standard procedure. before the procedure of pic, "introductory characteristics form for patients" was prepared by the researcher containing the sociodemographic characteristics of the participants (gender, marital status, age, educational status, etc. as such). this form was filled out by asking the patient by face-to-face interview method. after catheterization, the "visual comparison scale for pain" was used by the nurse practitioner to determine the pain of the patients and the "visual comparison scale for satisfaction" was used to determine the satisfaction status of the patients regarding the application to be performed. it is expected that pain and patient satisfaction scores in groups where a vrg and buzzy® were used during pic in adult patients will result more positively than in the control group. it is thought that the results obtained from the research will contribute to the literature.

Eligibility criteria:
inclusion criteria: * shold be a volunteer to participate in the research * should be in the age of between 18-65 years old * should not use drugs that will have an analgesic effect in the last 24 hours before admission * should have successful of the first intravenous catheterization attempt * absence of any psychiatric illness * absence of any oncology and hematology disease * should have the ability to read and write in turkish, * absence of vision, hearing and perception problems * should not have a febrile illness at the time of applications * should not have thin and damaged vascular structure * absence of a history of fainting during blood removal * should be conscious, fully oriented and cooperative, and open to communication exclusion criteria: * failure of the first attempt to administer intravenous catheterization * the unwillingness of the patient to continue the research * removing the virtual reality glasses before and during the procedure * discontinuing of buzzy ® before and during the procedure * deterioration of the patient's health status during the procedure

Keywords: nursing pain patient satisfaction peripheral intravenous catheterization thermomechanical stimulation virtual reality
protective effect of ulinastatin and thymosin α1 against negative immune dysregulation and organ dysfunction after acute aortic dissection surgery (panda xi)

Conditions: Aortic Dissection; Aortic Dissection Aneurysm

Summary: systemic inflammatory response syndrome (sirs) and multiple organ dysfunction syndrome (mods) are the major causes of death in patients with acute aortic syndrome (aas). therefore, the prevention of sirs and mods is of great clinical value, and immunomodulatory therapy with thymosin alpha 1 in addition to antiinflammatory treatment may be beneficial. this study was designed to test the hypothesis that the administration of ulinastatin and thymosin α1 during the acute phase of aas will result in a reduced incidence of sirs and mods.


Eligibility criteria:
inclusion criteria: * the patients are conformed to 2010 acc/aha guidelines for the diagnosis and treatment of thoracic aortic disease (tad) within two weeks of onset; * patients with acute aortic syndrome confirmed clinically and radiologically and planning to undergo emergency surgery were enrolled. * the patients' age between 18 \~90 years old. * agree to participate in the study and sign the informed consent. exclusion criteria: * patients allergic to thymosin α1 or ulinastatin; * lactating women and pregnant women; * patients with mental diseases, drug and alcohol dependence; * refuse to participate in this study and refuse to sign the informed consent.

Keywords: aortic dissection inflammation
analysis of line-field confocal optical coherence tomography (lc-oct) in characterization of gingival systemic health, gingivitis and periodontitis

Conditions: Gingival Diseases

Summary: the aim of the study is to identify tissue changes among healthy patients, patients with gingivitis and with periodontitis before and after treatment, by analyzing tissues changes through line-field confocal optical coherence tomography (lc-oct)

the tissue changes among healthy patients, patients with gingivitis and with periodontitis before and after treatment, by analyzing tissues changes through line-field confocal optical coherence tomography (lc-oct) will be evaluated through changes on epithelium before and after non surgical periodontal treatment

Eligibility criteria:
inclusion criteria: * diagnosis of gingivitis or periodontitis by the presence of elevated bleeding or probing index or probing pocket depth exclusion criteria: * smoking * any systemic diseases that could influence the gingival structure

Keywords: periodontitis, gingivitis, lc-oct
development of a blended lifestyle intervention to promote physical activity, diet, and health in hong kong older adults

Conditions: Health Behavior; Physical Activity; Healthy Diet

Summary: this pilot study will provide a theory-based low-cost and easy-to-operate program in the area of healthy lifestyle promotion among community dwelling older adults. the blended intervention product will be helpful for health professionals, social workers and practitioners working in the elderly centers and health centers to promote older adults' pa, healthy diet and wellness. furthermore, this study would initiate advocacy for policymakers to disseminate cost-saving, time-efficient and effective healthy lifestyle programs to the communities for healthy aging promotion.

project objectives 1. to review and meta-analyze lifestyle interventions for promotion of physical activity, diet and health among older adults. 2. to assess the feasibility of the pilot study. 3. to assess acceptability of the pilot study. 4. to examine between-group differences in changes of physical activity (min/week), diet (portion/day), physical health-related outcomes (physical fitness, blood pressure, fasting blood sugar, and blood lipids), mental health-related outcomes (depression, loneliness) and health-related quality of life (qol) among the sample. a series of generalized linear mixed models (glmm) will be applied to evaluate the intervention effects on outcome measures at t2, with time, groups, and their interaction as fixed effects. per-protocol analyses will be used for primary analyses, while intention-to-treat approach will be used for sensitivity tests.

Eligibility criteria:
inclusion criteria: * aged 65-79 years; * have access to the internet and smartphone; * speak cantonese; * pass the physical activity readiness-questionnaire (par-q) screening or have the physician's approval prior to participation. exclusion criteria: * no cognitive disorders or impairments; * unable to engage in physical activity;

Keywords: face-to-face intervention ehealth intervention health behavior change old adults
a clinical study to investigate how solifenacin fluid is taken up, how long it stays in the body and how effective and safe it is in treating children aged from 6 months to less than 5 years with symptoms of neurogenic detrusor overactivity (ndo)

Conditions: Neurogenic Detrusor Overactivity; Pediatric

Summary: the purpose of this study was to evaluate long term efficacy and safety of treatment with solifenacin succinate (the study drug) in children with neurogenic detrusor overactivity after multiple dose administration.

in some children with a severe form of spina bifida (which is the consequence of a spinal cord defect), the bladder muscle (detrusor) contracts strongly and without warning (also known as neurogenic detrusor overactivity) and the urethra (the passage connecting the bladder with outside) does not relax. though these children cannot void, urine leakage can happen when the overactive contractions are strong, and/or the pressure in the bladder is so high that it overcomes the closed urethra (overflow at high filling bladder pressure). this high bladder pressure puts these children at risk for kidney damage and can decrease the quality of the bladder. therapy was aimed to decrease the high filling bladder pressure and the overactive detrusor contractions.

Eligibility criteria:
inclusion criteria: * myelomeningocoele * documented diagnosis of ndo, confirmed by urodynamics * dsd (detrusor sphincter dyssynergia) * practicing clean intermittent catheterization (cic) exclusion criteria: * know genitourinary condition (other than ndo) that may cause incontinence * bladder augmentation surgery * current faecal impaction * electro-stimulation therapy within 2 weeks prior to visit * subjects with the following gastro-intestinal problems: partial or complete obstructions, decreased motility like paralytic ileus, subjects at risk of gastric retention * reflux grade 3 to 5 * current urinary tract infection

Keywords: solifenacin succinate suspension efficacy safety
extension program for bay 43-9006

Conditions: Neoplasm; Metastasis

Summary: the study was designed to allow for the continuation of treatment with sorafenib as a single agent to those patients who participated in a previous sorafenib study that had reached its designated end-date and who were, in the opinion of the investigator and the sponsor, still benefiting from treatment.


Eligibility criteria:
inclusion criteria: - patients who had participated in a previous sorafenib study that had completed, who did not meet withdrawal criteria of the previous study and who were, in the opinion of the investigator and sponsor still benefiting from treatment. exclusion criteria:- the current cardiovascular situation of the patient was carefully re-evaluated by both the investigator and the sponsor and an informed decision as to inclusion was then made.- substance abuse, medical, psychological or social conditions that may have interfered with the patient's participation in the study or evaluation of the study results.- known or suspected allergy to the investigational agent.- any condition that was unstable or which could jeopardise the safety of the patient and his/her compliance in the study.

Keywords: extension sorafenib survival
calcitriol supplementation in covid-19 patients

Conditions: COVID-19; Vitamin D Deficiency

Summary: this is a randomized, open label study to evaluate the efficacy and safety of calcitriol supplementation in covid-19 patients with vitamin d deficiency.

this is a randomized, open label study to evaluate the efficacy （clinical and laboratory change）and safety （serum calcium） of calcitriol supplementation in covid-19 patients with vitamin d deficiency.

Eligibility criteria:
inclusion criteria: 1. hospitalized symptomatic covid-19 patients; 2. covid-19 nucleic acid ct value \< 28 (both orf1ab gene ct value and n gene ct value \< 28); 3. vitamin d deficiency: 25ohd ≤ 20ng/ml; 4. age: 18-70 years old; exclusion criteria: 1. asymptomatic covid-19 patients ； 2. hypercalcemia; 3. history of primary hyperparathyroidism; 4. history of triple hyperparathyroidism; 5. patients who are allergic to calcitriol; 6. pregnant or lactating women; 7. patients with severe heart or lung diseases or tumor history; 8. patients already taking vitamin d or its similar preparations; 9. participants in other interventional clinical studies (including taking paxlovid); 10. patients with renal insufficiency (egfr\<60ml/min/1.73m2); 11. patients considered unsuitable for this study by the investigator；
the genetic effects of rs7903146 and dietary intake on type 2 diabetes mellitus risk in a healthy population

Conditions: Health Behavior; Blood Glucose, High; Diet Habit; Genetic Predisposition

Summary: this study investigates the association of genetic effects of rs7903146 and dietary intake on type 2 diabetes mellitus (t2dm) risk in a healthy population. t2dm risk was assessed through glycated haemoglobin (hba1c) concentration in 73 subjects. dietary intake was assessed using a validated food frequency questionnaire (ffq).

type 2 diabetes mellitus (t2dm) is a global epidemic linked to 1.6 million deaths in 2016. diet, lifestyle and environment contribute significantly to t2dm-risk. genome-wide association studies identify the transcription factor 7-like 2 (tcf7l2) rs7903146 (c/t) gene as one of the most important associated with t2dm-risk. the t-allele is associated with a two-fold increase in relative risk of t2dm across different populations. however, most studies associating genetic effects of dietary intake on rs7903146 and t2dm-risk utilised volatile instantaneous measures of glucose(5) and focussed on individual macronutrients. understanding the association of rs7903146 and overall macronutrient intake using a stable blood homeostasis marker may provide a fuller insight into t2dm-risk. the study included data for all variables (participant characteristics: sex (female/male), age (years), height (cm), weight (kg), body mass index (bmi) (kg/m2), body fat percentage (%), fat mass (kg), lean mass (kg), waist/hip (ratio), dietary intake, hba1c (mmol/mol and %) and physical activity (hours/week). all data was collected at st mary's university between april to july 2019. participants was genotyped and allocated into two groups: major allele (c) homozygote versus minor allele (t) homozygote plus heterozygote. t2dm-risk was assessed through their value of hba1c and participants were classified as follows: normal (\<42mmol/mol/ \<6.0%), pre-diabetic (42 to 47 mmol/mol/ 6.0% to 6.4%), diabetes (48mmol/mol /6.5% or over).

Eligibility criteria:
inclusion criteria: eligibility criteria required healthy adults free from metabolic condition and free from medication affecting glycated haemoglobin levels. exclusion criteria: individuals with hba1c levels ≥48 mmol/mol or ≥6.5% were excluded due to a classification as t2dm (who, 2011).