Kornimate/medical-research-clean huggingface dataset:
effects of exercise and energy balance on 24-hour blood glucose control

Conditions: Metabolic Disease; Adipose Tissue

Summary: the study team will assess "free-living" 24h glucose control using continuous glucose monitors (cgm) over an 88h period on two separate occasions. importantly, standardized meals will be provided and will be consumed at specific times each day of the cgm measurement period. these meals will be identical on day 1 and day 3 of measurement. each subject will complete two cgm periods, which will be identical except for the calorie and macronutrient content of the post-exercise dinner. in addition, during trial 1, two cgm's will be worn, while only 1 cgm will be worn on trial 2.

subjects will be instructed to exercise exactly 2 days before each experimental trial period, and then abstain from exercise other than the exercise session on day 2 of the trial period until after the trial period is complete. subjects will arrive to the substrate metabolism laboratory at approximately 4pm on day 0 of each trial. for trial 1, two cgm devices will be placed on either side of the abdomen, near the belly button. for trial 2, only one cgm device will be placed on one side of the abdomen. on day 1 of both trials, participants will go about their normal daily activities (other than planned exercise) while eating provided meals at designated time points. this day will serve as the non-exercise control day. on day 2, subjects will return to the laboratory to exercise on the bike for \~1h at a moderate exercise intensity (approximately 65% of their measured vo2peak) to expend 350 kilocalories. during trial 1 only, subjects will use the mouthpiece and nose clip (which will allow all of their expired air to pass through the metabolic cart for analysis of oxygen consumption and carbon dioxide production) for \~5 min at the beginning, middle and toward the end of exercise to verify they are exercising at 65% of vo2peak. this will also allow the study team to accurately measure energy expenditure (kcal) during exercise. on trial 2, subjects will perform the exact same exercise protocol, but the mouthpiece and nose clip will not be required. one hour after the exercise session, participants will eat their standardized dinner. importantly, the caloric content of this meal will differ between the two trials (+/- 350kcal), and this will be the only difference between the two study trial periods. on day 3, participants will go about their normal daily activities (other than planned exercise) while eating the provided meals at designated time points. this day will serve as the post-exercise day. on day 4, participants will return to the laboratory at approximately 8am for removal of the cgm device(s).

Eligibility criteria:
inclusion criteria * age: 18-40 * body mass index: 20-30 kg/m2 exclusion criteria * pregnant or lactating * evidence/history of cardiovascular or metabolic disease * medications known to affect glucose metabolism

Keywords: exercise
the effect of probiotics on gums health and bad breath

Conditions: Gingivitis

Summary: the study is about using healthy bacteria to improve the overall gingival and overall health and prevent or decrease the bad odor of the mouth caused by bad bacteria

the goal of this study is to verify the effect of probiotics on oral health status and eliminate the gingival disease and halitosis by measuring the levels of salivary biomarkers (cytokine il-1b and proteases matrix metalloproteinase (mmp-8) in saliva) and level of volatile sulfur compounds (vscs) and their effects on improving gingival diseases clinical parameters in person age of (17-25) years old. the participants are randomly divided into two parallel groups (a, b). group a will take probiotics and group b will take placebo for 28 days. the levels of il-1b, mmp-8 in saliva, and vscs measurement will be recorded respectively in different intervals of zero time and repeated on 14 days and 28 days. statistical analysis will be done then comparative between two groups

Eligibility criteria:
the inclusion criteria * subjects (male and female) between the age range 17-25 years old. * subjects with mouth breathing habit. * subjects with orthodontic and prosthodontic appliance * race from iraq. * subjects having a dentition with ≥20 evaluable teeth (minimum of five teeth per quadrant). the exclusion criteria * history of chronic disease. * history of systemic disease. * patients with autoimmune diseases. * patients under antibiotic treatment. * pregnant, lactating females. * history of undergoing nonsurgical and surgical periodontal therapy in the last 6 months.

Keywords: probiotics and gingival health
effectiveness of cingal™ for improving pain scores and function in anterior knee pain

Conditions: Anterior Knee Pain Syndrome

Summary: anterior knee pain (akp) is a common condition that can be challenging to treat effectively. the main goal of treatment regimens is to improve the function of the knee. however, treatment can be challenging due to the knee pain experience. cingal™ contains hyaluronic acid (ha), which acts as a joint lubricant, and the corticosteroid triamcinolone hexacetonide (th). some studies have shown that cingal™ can improve joint function and provide short-term pain relief.


Eligibility criteria:
inclusion criteria: * age 18 - 35 years * standard weight-bearing ap and skyline view knee x-rays * retropatellar or peripatellar knee pain for a minimum of 2 months * confirmed diagnosis of akp that has failed to improve with a minimum of 6 weeks of conservative treatment (activity modification, supervised physiotherapy, exercise therapy, taping or bracing, nsaids) * pain aggravated by at least two of the following patellofemoral joint loading activities: squatting, running, ascending or descending stairs, or sitting with prolonged knee flexion. exclusion criteria: * x-ray evidence of knee osteoarthritis or fracture * meniscal or ligamentous injury assessed or suspected on clinical examination * previous knee surgery * history of patellar instability * any contraindication to knee injection (overlying skin condition, joint infection, significant joint effusion, coagulopathy, previous adverse reaction, etc.) * known allergy to cingal™ or its constituents * previous knee injection within the last 3 months * bmi greater than 30 kg/m2 * diabetes, inflammatory conditions (rheumatologic disease, ankylosing spondylitis), or concurrent medical conditions which may result in chronic pain or altered pain sensation * pregnant or breastfeeding * workers compensation board case * patient involved in litigation
prediction of weaning outcomes by using rate of change of rapid shallow breathing index

Conditions: Rapid Shallow Breathing

Summary: this trial examines weaning outcomes using the rapid shallow breathing index rate.

we hypothesize that the trend of the rapid shallow breathing index or rsbi rate, is a better predictor of weaning outcome than the rsbi as a single value during the weaning trial. patients are recruited during a weaning trial on t-piece and the rsbi during what the rsbi is measured periodically. the outcome is ventilatory status at 24 hours after the weaning trial.

Eligibility criteria:
inclusion criteria: * requires need of mechanical ventilation for \> 48 hours with a tube size no smaller than 7.5 exclusion criteria: * healthy volunteers

Keywords: rapid shallow breathing index mechanical ventilation
bowel preparation regimen for colon capsule endoscopy procedure

Conditions: Colon Cancer; Inflammatory Bowel Diseases; Gastrointestinal Bleed; Colon Polyp

Summary: the study aims to investigate the effect of the optimized bowel preparation and boost regimens on colon capsule endoscopy procedures, specifically on cleanliness and completion rate.

colon capsule endoscopy (cce) is a promising modality for lower gastrointestinal (gi) investigations in clinical routine and screening. furthermore, the double-headed camera capsules are being applied for panenteric investigations, with promising results. the major limitation to its use has been finding a bowel preparation that will clean the colon adequately for good visualization of the mucosa and help propel the capsule using boosters through the colon. to achieve wider cce adoption, challenges regarding completion rates (cr) and adequate cleanliness rates (acr) must be handled. cr and acr should be improved to meet the standards for optical colonoscopy (oc) from the european society of gi endoscopy (esge). esge recommends both cr and acr ≥ 90%. recently, a meta-analysis of preparation regimens for cce confirmed that cr and acr were suboptimal. this study is designed to investigate the cr, acr, and diagnostic yield (dy) of very low-volume polyethylene glycol (peg) - based laxative compared to a conventional high-volume laxative and the use of different boosters. all consecutive patients referred for colon capsule endoscopy will be enrolled in the study. pillcam® crohn's capsule will be used. patients will undergo a split-dose bowel preparation with a very low-volume peg-based laxative. in the study arm nr1 gastrografin and magnesiumoxid + sodium picosulfate will be used. in the study arm nr 2, the same regimen will be used but completed with 2 mg of prucalopride before ingesting the capsule. the results of the study arms will be compared to the previously used standard regimen with 4 l of peg as a laxative and sodium phosphate as a booster. the images from the colon capsule will be reviewed, and the quality of bowel preparation (cleanliness rates) and completion rate will be evaluated. patient tolerance of the bowel preparations and diagnostic yield of colon capsule endoscopy using the different preparation regimens will also be evaluated.

Eligibility criteria:
inclusion criteria: * subject referred for clinical colon/panenteric examination * subject received an explanation about the nature of the study and agreed to provide written informed consent exclusion criteria: * subject with dysphagia or any swallowing disorder * subject with a prior stomach, small bowel, or colonic resection * subject with severe renal insufficiency * subject with any allergy or other known contraindication to the medications used in the study * women who are either pregnant or nursing * subject suffers from life threatening conditions

Keywords: colon capsule endoscopy panenteric capsule endoscopy colon preparation
a study to investigate the efficacy of zanubrutinib plus rituximab compared with bendamustine plus rituximab in adults with previously untreated mantle cell lymphoma who are ineligible for stem cell transplantation

Conditions: Mantle Cell Lymphoma; Non-Hodgkin Lymphoma

Summary: this is a randomized study to compare the efficacy and safety of zanubrutinib plus rituximab versus bendamustine plus rituximab in previously untreated participants with mantle cell lymphoma (mcl) who are not eligible for stem cell transplantation.


Eligibility criteria:
key inclusion criteria: 1. ≥70 years of age at the time of informed consent, or ≥60 and \<70 years of age with comorbidities precluding autologous stem cell transplantation 2. histologically confirmed diagnosis of mcl 3. no prior systemic treatments for mcl 4. measurable disease by ct/mri 5. eastern cooperative oncology group (ecog) performance status of 0-2 6. adequate marrow and organ function key exclusion criteria: 1. known central nervous system involvement by lymphoma 2. participants for whom the goal of therapy is tumor debulking prior to stem cell transplant 3. clinically significant cardiovascular disease 4. history of severe bleeding disorder 5. unable to swallow capsules or disease significantly affecting gastrointestinal function 6. active fungal, bacterial and/or viral infection requiring systemic therapy 7. requires ongoing treatment with a strong cyp3a inhibitor or inducer note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: mcl, nhl, btki
evaluation of the activity of a pharmacological "anticellulitis" product vs. a reference product on the market

Conditions: Healthy

Summary: aim of this study was to evaluate by clinical, morphometric and non invasive instrumental evaluations the activity of an "anticellulitis" cosmetic product vs a reference product of the market (comparison within subjects), applied once a day, for an uninterrupted period of 4 weeks, on 22 female healthy volunteers with low/moderate oedematous - fibrosclerotic lipodystrophy on the thighs. it was also aim of the study to evaluate cosmetic acceptability by the volunteers and products efficacy and tolerance both by investigator and volunteers.


Eligibility criteria:
inclusion criteria: * female volunteers * volunteers aged more than 18 years old * volunteers with low/moderate oedematous - fibrosclerotic lipodystrophy on the thighs * volunteers with no weight variation (± 1.5 kg) during the last month preceding the study inclusion * volunteers with regular menstrual cycle (28-32 days) or in menopause from at least 2 years * volunteers who are giving a written informed consent. exclusion criteria: * pregnancy * lactation * smoke (admitted 10 cigarettes/day) * assumption of alcoholic drinks/wine/beer (admitted up to 125 ml for meal) * oral contraceptive/replacement therapy started less than 1 year ago * alimentary diet * change in the normal habits in the last month (unusual physical activity) * use of any product or weight-loss treatment (manual or instrumental massage) on skin test areas during the last month * use of any drug able to cause a weight body variation * presence of clinically important vascular disorders * insufficient adhesion to the study protocol and to the treatment * participation in a similar study during the previous month * dermatological disease * clinical and significant skin condition on the test area (e.g. lesions, scars, malformations) * suspect thyroid disfunction * thyroid disorders/diseases * other endocrine diseases as diabetes, metabolic disorders etc. * hepatic, renal or cardiac disorder * cancer * topical drugs or surgical procedure on the test areas during the previous 3 months * systemic corticosteroids * aspirin or non-steroid anti-inflammatory drugs (fans) * diuretic drugs

Keywords: cellulitis anticellulitis
the dortmund vital study: impact of biological and lifestyle factors on cognitive performace and work ability

Conditions: Age-related Cognitive Decline

Summary: the goal of the dortmund vital study is to validate previous hypotheses and to generate and validate new hypotheses about the relationship of ageing, working conditions, genetic makeup, stress, metabolic functions, cardiovascular system, immune system, and mental performance over the lifespan with a focus on healthy working adults. the dortmund vital study is a multidisciplinary longitudinal study involving the departments of ergonomics, immunology, psychology and neurosciences, and toxicology of the leibniz research centre for working environment and human factors at the tu dortmund (ifado) in dortmund, germany, as well as several national and international cooperation partners.

the dortmund vital study is designed as a combined cross-sectional and longitudinal study. about 600 subjects aged between 20 and 70 years will participate. a wide range of demographic, psychological, behavioral, sensory, cardiovascular, biochemical, immunological and biochemical data, a comprehensive eeg-based cognitive test battery as well as structural and functional magnetic resonance imaging (mri) have been included in the study. specifically, parameters obtained by mri and eeg-related measures can be evaluated as a function of polygenic scores, metabolic products, concentration of immune cells, immune age and infections, such as toxoplasmosis or covid-19 that are largely unexplored. the same is true for environmental and lifestyle factors that impact on brain activity and behavior. the initial testing has been conducted between 2016 and 2021 and will be repeated every five years (three follow-up measures until 2035). the study will shed light on sources of large inter-individual differences in cognitive functioning with increasing age and reveal biological and lifestyle markers contributing to work ability, longevity and healthy aging on the one hand, and on risk factors for cognitive decline, mild cognitive impairment or even dementia on the other.

Eligibility criteria:
inclusion criteria: * blood thinners * hormones * antihypertensives * cholesterol reducers * normal or corrected-to-normal vision and hearing * fulfill standard inclusion criteria for mri measurements * sufficient language skills exclusion criteria: * dementia * parkinsonism * stroke * cardiovascular diseases * bleeding tendency * oncological diseases * schizophrenia * obsessive-compulsive disorder * anxiety disorders * severe depression * head injuries * head surgery * head implants * eye diseases (cataract, glaucoma, blindness) * accidents that limit physical fitness and mobility * psychotropic drugs * neuroleptics

Keywords: cognitive ageing occupational health neuropsychology metabolism cardiovascular system behavioral genetics immunology eeg mri psychoneuroendocrinology infectious diseases cognitive neuroscience
chemoreflex control of sympathetic activity in patients with coronary artery disease

Conditions: Coronary Artery Disease (CAD); Obstructive Sleep Apnea (OSA)

Summary: the investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity (msna) during hypoxia and hypercapnia will be increased in coronary artery disease (cad) patients and that the presence of obstructive sleep apnea (osa) will potentiate these responses. and, that the exercise training would decrease the chemoreflex response of msna in these patients.

forty patients with coronary artery disease, with (n=20) and without (n=20) obstructive sleep apnea will be studied. a healthy control, age-paired group (n=10) will be also evaluated. the patients will be submitted to a polysomnography and randomized for clinical follow-up or exercise training for four months. it will evaluated the autonomic function, chemoreflex control of sympathetic activity during hypoxic and hypercapnic maneuvers, endothelial function and inflammatory markers.

Eligibility criteria:
inclusion criteria: * diagnosis of stable coronary artery disease; age between 35-60 years, male and female; bmi \<30 kg/m2 not involved in a regular exercise program at least three months before the survey; exclusion criteria: * patients with angina and / or ischemia, * patients with diabetic neuropathy and / or ischemia of the lower limbs; * previous diagnosis of chronic pulmonary, neurological and orthopedic diseases, neoplasia, renal failure and insulin-dependent diabetes mellitus; * patients with acute myocardial infarction, cardiac surgery or hospitalization of cardiac origin six months before the study and carriers of pacemaker / implantable defibrillator; * patients with cardiac dysfunction (ejection fraction of left ventricle \<40%); * current smoking and pregnant women.

Keywords: coronary artery disease chemoreceptors sympathetic nerve activity exercise
multidimensional and multimodal profiling of oropharyngeal carcinoma

Conditions: Oropharyngeal Carcinoma; Human Papilloma Virus

Summary: the purpose of this study is to better understand the natural history of oropharyngeal carcinoma (opc), with or without an association with the human papilloma virus (hpv). for this study, the investigators plan to collect blood from opc patients prior to treatment and at six subsequent time points.


Eligibility criteria:
inclusion criteria: * patients diagnosed with oropharyngeal carcinoma or patients with cancer of the unknown primary that is hpv associated, or possibly deemed to be originating from the oropharynx. exclusion criteria: * not willing to sign consent
pressure course in the tube cuff during swallowing

Conditions: Anesthesia; Intensive Care

Summary: leakage of fluid from the subglottic space to the lungs occurs along the longitudinal folds within the wall of endotracheal tube (ett) cuffs. in this project the researchers investigate the possible effect of swallowing on the pressure course in the ett cuff.


Eligibility criteria:
inclusion criteria: * age over 18 years * general anaesthesia or intensive care medicine treatment exclusion criteria: * refusal of written informed consent

Keywords: endotracheal tube swallowing aspiration cuff pressure pneumonia
promoting treatment access following pediatric primary care depression screening

Conditions: Depression

Summary: major depression (md) in youth is a serious psychiatric illness with extensive morbidity and mortality. the american academy of pediatrics recently released practice guidelines promoting primary care (pc)-based youth md screening; however, even when diagnosed by pc providers, \<50% of youth with md access treatment. thus, a need exists for interventions that are feasible for youths and parents to access and complete-and that may strengthen parents' likelihood of pursuing longer-term services. single-session interventions (ssis) may help forward these goals. ssis include elements of comprehensive treatments, but their brevity makes them easier to disseminate at scale. meta-analytic evidence suggests ssis can reduce youth psychopathology, including self-administered (e.g., online) ssis. one computer-based ssi, teaching growth mindset (gm; viewing personal traits as malleable), has reduced adolescent depressive symptoms in multiple rcts; gm-ssis have also improved parents' expectancies that psychotherapy could benefit their children's mental health. this project will test whether these online, youth- and parent-directed gm-ssis-designed to reduce youth depressive symptoms and improve parents' mental health treatment expectancies, respectively-may increase mental health service access, reduce youth depressive symptoms, and relieve parental stress following pc-based youth md screening. youths reporting elevated md symptoms at pc visits (n = 200) will receive either information/psychoeducation/referral (ipr) or ipr plus parent- and youth-directed gm-ssis (ipr+ssi). the investigators will examine whether ipr+ssi, versus ipr alone, increases md service access; reduces parental stress; and reduces youth depressive symptoms across three months. results may yield a disseminable model for promoting youth treatment access after pc-based depression screening.


Eligibility criteria:
inclusion criteria: * youth is between the ages of 11 and 16, inclusive, at the time of study recruitment * youth reports a pediatric symptom checklist 'internalizing' score of 5 or higher (out of 10) at her/his most recent pediatric primary care visit at 1 of the 9 stony brook university-affiliated clinics participating in this study * parent and youth are comfortable with reading and writing in english * parent and youth are comfortable with online activity exclusion criteria: * parent or youth is not comfortable reading and/or writing in english * parent or youth is not comfortable with online activity