Kornimate/medical-research-clean huggingface dataset:
minimal versus conventional exposure in unicompartmental knee arthroplasty

Conditions: Knee Osteoarthritis

Summary: the purpose of this study is to determine whether minimal invasive surgery results in less postoperative pain and better mobilization than conventional technique in unicompartmental knee arthroplasty, provided that both groups receive local infiltration analgesia.

postoperative pain is often moderate to severe following unicompartmental knee arthroplasty. in order to reduce postoperative pain and improve mobilization the minimal invasive technique was developed. after a 8-10 cm skin incision, a medial parapatellar capsule incision in made. the rectus tendon or the vastus medialis are not incised and the patella is not everted. in recent years the local infiltration analgesia (lia) technique has been developed to reduce postoperative pain. with this lia-technique, a long-acting local anesthetic (ropivacaine), a nonsteroidal anti-inflammatory drug (ketorolac), and epinephrine are infiltrated intraoperatively and via an intraarticular catheter postoperatively. the aim of this study is to investigate if minimal invasive surgery results in less postoperative pain and better mobilization than conventional technique in unicompartmental knee arthroplasty, provided that both groups receive local infiltration analgesia.

Eligibility criteria:
inclusion criteria: * patients scheduled for unicompartmental knee arthroplasty * aged 20-80 yrs * asa physical status i-iii and mobility indicating normal postoperative mobilization exclusion criteria: * known allergy or intolerance to local anesthetics, asa or nsaid * serious liver-, heart- or renal decease * rheumatoid arthritis * chronic pain or bleeding disorder

Keywords: unicompartmental knee arthroplasty surgical exposure minimal invasive surgery local infiltration analgesia knee arthroplasty
exercise and behavioral therapy in obese children

Conditions: Childhood Obesity

Summary: the aim of this study is to compare the effects of exercise training and family-based behavioral treatment, either in individual or in group setting, in pre-pubertal children and their mother.

introduction: the prevalence of childhood obesity is increasing rapidly in developing countries. the aim of this study is to determine the effects of exercise training and family-based behavioral treatment (fbbt), either in individual or in group setting,in pre-pubertal children and their mother. methods: this is a 6-month randomized controlled trial (rct) including 75 pre-pubertal obese children (age 8-11 years) randomly assigned to an intervention (i, n=50) or a control group (c, n=25). the intervention consists of a family-based behavioural therapy in group (1 session/week with a dietician and a psychologist) or in individual setting (paediatrician or dietician 1x/month). the intervention includes exercise training sessions twice a week (60 minutes each). measures include: body mass index (bmi), waist and hip circumferences; whole body and abdominal fat mass by dxa; resting and ambulatory blood pressure; arterial intima-media thickness and vascular reactivity (flow-mediated dilation)using high resolution ultrasound; arterial stiffness by tonometry of applanation; cardiorespiratory fitness by a treadmill test; physical activity; fasting lipids, glucose, insulin, and c-reactive protein levels; health-related quality of life and psychological health using standardized questionnaires and a semi-structured interview. measures are completed in children and their mother at baseline and 6 months post-randomization.

Eligibility criteria:
inclusion criteria: * childhood obesity (\>97 percentile who references) exclusion criteria: * being involved in any weight control, physical activity, behavior therapy, or gastric surgery program; * familial history of dyslipidemia or essential hypertension; * medications or hormones, which may influence cardiovascular function, body composition, lipid or glucose metabolism in the preceding 6 months; * orthopaedic affection limiting physical activity; * genetic disorder or another chronic disease;

Keywords: obesity children behavior family exercise
ml-004 in adolescents and adults with autism spectrum disorders (asd)

Conditions: Autism Spectrum Disorder

Summary: ml-004-002 is a multi-center, randomized, double-blind, parallel-group, placebo-controlled study that will enroll approximately 150 adolescent and adult subjects with asd. the primary objective is to evaluate the efficacy of ml-004 compared with placebo in the improvement of social communication deficits in subjects with asd.


Eligibility criteria:
inclusion criteria: * age 12 to 45 at screening * has a designated care/study partner who can reliably report on symptoms * has a diagnosis of autism spectrum disorder (asd) * has a body mass index (bmi) 18 through 34 kg/m², inclusive * full scale iq (or equivalent) ≥55 score, with adequate verbal fluency, as determined by the principal investigator. * psychoactive medications and adjunctive therapies are stable for 4 weeks prior to screening * must be able to swallow study medication exclusion criteria: * has rett syndrome or child disintegrative disorder * has participated in any other study and received any other investigational medication (other than covid-19 vaccination) or device within 60 days prior to screening * history of epilepsy without current adequate control, or any seizure in the 6 months preceding screening * history of suicidal ideation or behavior in the past 12 months, or a positive response to c-ssrs questions 4 and/or 5 * systolic blood pressure ≥140 mmhg (if adult) or \>135 mmhg (if adolescent), or diastolic blood pressure ≥90 (if adult) or \>85 mmhg (if adolescent), or a clinical history of uncontrolled or severe hypertension * if female, is pregnant or lactating

Keywords: asd autism autism spectrum disorder social communication
multidisciplinary intervention with cognitive remediation therapy for obese adults

Conditions: Obesity

Summary: this study aims to describe the research procedures and treatment of a multidisciplinary intervention with cognitive remediation therapy for adults with obesity in a randomized controlled trial. the changes will be measured before and after the intervention and three months follow-up. to evaluate them, psychometric, psychological, physiological, and physical activity tests will be taken.

a randomized controlled clinical trial will be carried out, implementing a multidisciplinary intervention with cognitive remediation therapy on obese adults from ciudad juárez, chihuahua, méxico. the efficacy of this therapy has been proved in several countries except méxico. a randomized controlled trial (rct) will be executed with both an experimental group and a control group, with repeated measures taken before and after intervention and follow ups of three months. the study will be simple blind and randomization technique will be use to one assign to one of the two conditions. the experimental group will first receive the intervention and once finalized, it will be applied to the control group. the investigator's hypothesis suggests that an intervention of cognitive remediation therapy implemented simultaneously with nutritional education and physical activity improvement in body composition such a body mass index (bmi), waist ratio, body fat, blood chemistry, skin conductance, eating behavior, craving, and body image. an improvement is also expected for the values in the applied psychophysiological tests, the cognitive performance, as well as the eating behavior and physical activities of the participants.

Eligibility criteria:
inclusion criteria: * ages 19-60 * bmi \>30 * bfp \>25 (women) * bfp \>32 (men) * high waist circumference \>88 cm (women) * high waist circumference \>94 cm (men) * signed informed consent exclusion criteria: * if the participant is enrolled in a weight control or physical exercise program. * if the participant is under any medical psychological treatment * if the participant is presenting any eating disorder, a thyroid or neurological diseases * pregnant women * unfinished procedures * less than 20% of assistance during the intervention

Keywords: adult obese cognitive remediation therapy multidisciplinary
thoracic lymphatic pump techniques for reducing lung volumes in persons with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the primary goal of this line of research is to see if realistic manipulative protocols can be developed to produce sustained reductions in residual volume and improve pulmonary function parameters in people with chronic obstructive pulmonary disease (copd).

this study is a prospective randomized crossover study to evaluate the effects of two different manipulation techniques on pulmonary function parameters in persons with copd. thirty-six (36) subjects will be enrolled in the study in order to complete the study with at least 30 subjects. pulmonary function measures will include spirometry and lung volume. the pulmonary function testing will be done baseline, 30 minutes post-treatment, and 3 hours post-treatment. the study protocol treatment consists of a five-minute treatment session of one of the two studied treatment techniques given in a random order. after a washout period of at least four weeks, the subject will return for a second treatment session using the other technique.

Eligibility criteria:
inclusion criteria:all subjects must be age 50 or older, have a history consistent with the diagnosis of copd, and have documented airflow obstruction and an increased residual volume on pulmonary function testing. airflow obstruction is defined as an fev1/fvc ratio of 70 percent or less of the predicted value and a rv of 120 percent or greater of the predicted value. - exclusion criteria:subjects will be excluded if they have received any form of manipulative treatment in the 3 months prior to enrolling in the study. subjects with acute respiratory illness, such as an exacerbation of copd, acute bronchitis, or pneumonia will be excluded from the study. persons unable to cooperate and follow instructions to complete pulmonary function testing due to dementia or other cognitive disorders will be excluded as will persons with spinal scoliosis greater than 25 degrees, significant chest wall deformity, and acute rib or compression fracture of the vertebra, unstable angina, or unstable congestive heart failure. -

Keywords: copd pulmonary
innovative multigenerational household intervention to reduce stroke and cvd

Conditions: Stroke; Cardiovascular Disease

Summary: american indians (ai's) are experiencing an epidemic of stroke morbidity and mortality, with higher prevalence and incidence, younger age at onset, and poorer survival than other racial and ethnic groups. with a stroke incidence more than twice that of the general u.s. population, stroke in ai's is a public health problem of staggering scope. ai's also have disproportionate burdens of many risk factors for stroke, including hypertension, smoking, obesity, and diabetes. however, no rigorous, population-based studies of stroke prevention have included ai's. the investigators at wsu, and community partners, have designed the "family intervention in the spirit of motivational interviewing" (fitsmi), a program delivered at the household level to encourage lifestyle changes that transform the home environment and reduce stroke risk for all residents. fitsmi uses a "talking circle" format in which facilitators guide participants to identify goals for change and create a tailored plan for sustainable implementation that may target smoking, exercise, diet, or medication adherence. fitsmi requires just 2 sessions (baseline and 1 month post-baseline), with text messaging used to boost long-term adherence. in a group-randomized trial design, the investigators will recruit 360 households where strong heart family study members aged 45 and older reside. the investigators will assign half to fitsmi and half to a control condition that receives educational brochures.


Eligibility criteria:
inclusion criteria: * household must include one member over the age of 45 (index participant) exclusion criteria: * under the age of 11
the effect of fish oil supplementation on vocal performance

Conditions: Voice Range Profile; Reflux Symptom Index; Evaluation of Ability to Sing Easily; Body Composition

Summary: the purpose of this study was to determine if use of omega-3 pufa supplement in combination with a singer's training regimen enhances training adaptations and body composition.


Eligibility criteria:
inclusion criteria: * apparently healthy college vocal performers (male and female of all ethnicities) \*between the ages of 18-28 years * majoring in classical voice in the baylor university school of music or musical theatre in the baylor university department of theatre arts. exclusion criteria: * previously diagnosed with a voice disorder * vegans * smokers * allergic to fish, shellfish or safflower oil * have been taking daily fo n-3 supplement within the past three months, or any supplement known to effect muscle biology (e.g. creatine).
accelerated partial breast radiotherapy with either mammosite or intensity modulated radiotherapy

Conditions: Breast Cancer

Summary: accelerated partial breast irradiation by mammosite and intensity modulated radiotherapy is safe and effective in patients with early stage breast cancer resected by lumpectomy.


Eligibility criteria:
inclusion criteria: * be a tis, t1, n0, m0 ajc classification * have negative surgical margins (\> or = 2 mm) after final surgery * should have adequate skin spacing between balloon surface and surface the skin (\> 7 mm)\* * patients with infiltrating lobular histologies should have breast mri scanning as part of the initial staging to verify localized t1, or tis disease * multifocal findings (define as 2 or more breast quadrants) on mri scanning should be further evaluated by ultrasound and, if necessary biopsy, to exclude multiquadrant disease. exclusion criteria: * be pregnant or breast-feeding * have collagen-vascular disease * inadequate surgical margins (\< 2 mm) * patients with malignant/suspicious calcifications

Keywords: breast-conservation accelerated partial breast irradiation apbi imrt intensity modulated radiotherapy breast brachytherapy lumpectomy early stage breast cancer dcis mammosite
diagnostic evaluation of urine dna methylation/somatic mutation profiling for the detection of urothelial carcinoma

Conditions: Urothelial Carcinoma; Bladder Cancer

Summary: clinical trial to evaluate the performance characteristics(sensitivity and specificity) of anchordx's urine dna methylation/somatic mutation profiling assay for detecting urothelial carcinoma compared to pathology in patients.

this is a prospective study that involves 11 centers in china and 1200 participants. the assay analyzes the dna methylation/somatic mutation profiles of bladder cancer-specific biomarkers non-invasively using urine specimens collected before invasive diagnosis/treatment. the performance characteristics(sensitivity and specificity) of the assay for detection of urothelial carcinoma is evaluated in comparison to pathology or cystoscopy.

Eligibility criteria:
inclusion criteria: 1. urothelial carcinoma group: * any male or female patient aged 18 or older. * able to provide urine specimen (100ml for both first void and non-first-void urine) before treatments. * diagnosed with incident or recurrent urothelial carcinoma (including bladder/ureter/renal pelvis) by surgery. 2. interference group: * any male or female patient aged 18 or older. * able to provide urine specimen (100ml for both first void and non-first-void urine) before treatments. * diagnosed with incident or recurrent bladder cancer other than urothelial carcinoma (including bladder squamous cell carcinoma/bladder adenocarcinoma/other bladder-related cancers/prostate cancer/rectal cancer) by surgery. 3. control group: * any male or female patient aged 18 or older. * able to provide urine specimen (100ml for both first void and non-first-void urine) before treatments. * diagnosed with urinary disease such as urinary calculi, urinary tract infection (except urinary tuberculosis), benign prostatic hyperplasia, glandular cystitis. all enrollee are able to provide legally effective informed consent. 4. healthy volunteers group: * any male or female patient aged 18 or older. * able to provide urine specimen (100ml for both first void and non-first-void urine) before physical examination. exclusion criteria: 1. urothelial carcinoma/interference group/control group * has had diagnosed with other cancers. * patients diagnosed with non-urological cancer. * failed to provide a written informed consent. 2. healthy volunteers group: * volunteers with abnormal test results of urine analysis or urological ultrasound test. * volunteers sceptical of cancers from non-urological origin in a normal results of urine analysis or urological ultrasound. * failed to provide legally effective informed consent.

Keywords: bladder cancer urine dna methylation somatic mutation
wound healing after emergency appendicectomy

Conditions: Appendicitis

Summary: the purpose of this trial is to compare two techniques of wound closure in open appendicectomies in adult patients: continuous, absorbable, intradermal suture and interrupted, non-absorbable sutures.


Eligibility criteria:
inclusion criteria: * adult patient with acute appendicitis exclusion criteria: * children

Keywords: appendicitis appendicectomy stitches wound healing cosmetic results
low-temperature radiofrequency coblation micro-tenotomy for the treatment of achilles tendinopathy

Conditions: Achilles Tendinopathy

Summary: this is a prospective randomized, double-blinded, placebo-controlled superiority trial with two parallel groups and a 1:1 allocation ratio to investigate the effectiveness of radiofrequency coblation micro-tenotomy for patients with achilles tendinopathy. all participants will be randomized into two groups: the intervention group (n=24; radiofrequency coblation micro-tenotomy + endoscopic achilles debridement) and the control group (n=24; endoscopic achilles debridement only). adults (age \>18) with clinically diagnosed midportion achilles tendinopathy will be recruited and scheduled for ultrasound screening. all participants will undergo a 12-week eccentric exercise program taught by a registered physiotherapist / athletic trainer. undergo endoscopic achilles debridement and radiofrequency coblation micro-tenotomy intervention. criteria for discontinuing or modifying allocated interventions, strategies to improve adherence to interventions, relevant concomitant care permitted or prohibited during the trial and provisions for post-trial care. outocme measure will use visa-a, pain scores, ultrasound measurement of thickness and vascularity, calf muscle strength, and ankle range of motion.


Eligibility criteria:
inclusion criteria: * the inclusion is ultrasound-confirmed achilles tendinopathy. adults (age \>18) with clinically diagnosed midportion achilles tendinopathy will be recruited and scheduled for ultrasound screening. ultrasonography diagnostic criteria include a thickened achilles tendon and a colour doppler of at least 1 out of 3 in the öhberg score 2-6 cm proximal to the achilles tendon insertion. victorian institute of sports assessment -achilles (visa-a) scores below 60 points. exclusion criteria: * patients will be excluded if they had a history of major injury or surgery on the affected lower limb in the past year and have mental/physical limitations hindering the participant's ability to complete assessments (ankle arthritis, neuromuscular disorders, etc.), including severe cognitive impairment and psychiatric disorders.
treatment of ocular discomfort in glaucoma patients using multiple topical medications

Conditions: Glaucoma; Ocular Surface Disease

Summary: to evaluate glaucoma patients' response to treatment with xiidra, an fda-approved drug for ocular surface discomfort, which will be prescribed as standard of care treatment.

to assess glaucoma patients' response to treatment with xiidra (lifitegrast ophthalmic solution) 5% for ocular surface discomfort caused, in part, by topical glaucoma antihypertensive medications.

Eligibility criteria:
inclusion criteria: * currently using one or more topical glaucoma antihypertensives * self-described symptoms of ocular surface discomfort * xiidra is being prescribed as part of the subject's standard care exclusion criteria: * history of glaucoma filtration surgery, history of ocular surface surgery (pterygium, conjunctivoplasty, etc.), * current use of topical cyclosporine * current use of topical steroids * incisional ocular surgery within 6 months

Keywords: glaucoma xiidra™ ocular surface discomfort
efficacy of gamification with escape-room for arrhythmia identification in critical patients

Conditions: Arrythmia; Health Education; Escape-Room

Summary: introduction: health education provided through the escape-room is still a recent approach in educational methodology and tends to be a strategy that benefits nursing students, particularly in gaining knowledge and skills. however, few studies have explored the use of both in-person and virtual escape-room as an educational methodology in nursing. objective: to assess the effectiveness of the gamification strategy through the in-person escape-room model compared to the virtual model in enhancing cognitive and affective competencies for recognizing cardiac arrhythmias in critical care patients within the nursing field. method: a randomized clinical trial to be conducted with nursing students from higher education institutions in the federal district, brazil. students will undergo a theoretical class on cardiac arrhythmias in critical patients and will then be randomized to experience either the in-person or virtual escape-room scenario. knowledge tests, the depression, anxiety, and stress scale, satisfaction and self-confidence scale in nursing management learning, and perceived gains will be administered pre and post-intervention. results with p≤0.05 will be considered significant. expected results: it is anticipated that this study will contribute to the enhancement and broadening of cognitive and affective competencies in nursing students, improving the quality of care through an active educational strategy like the escape-room, and consequently reducing costs for the unified health system by minimizing errors in recognizing clinical changes in critical patients. additionally, the study aims to address gaps in understanding the use of educational escape-rooms in the field of nursing.


Eligibility criteria:
inclusion criteria: * students enrolled in the undergraduate nursing program who have successfully completed the course related to adult and elderly health. exclusion criteria: * healthcare professionals, including those participants who, at any point during the research stages, choose to withdraw or who have not completed/participated in one of the study phases.