Kornimate/medical-research-clean huggingface dataset:
comparative study of two tetanus toxoid vaccination strategies: cold chain versus controlled temperature chain

Conditions: Tetanus; Tetanus Vaccine

Summary: the purpose of this study is to determine the effectiveness, safety and feasibility of a tetanus toxoid (tt) vaccination strategy relying on the maintenance of vaccines in a controlled temperature chain (ctc). the ctc is defined as the storage and transport of vaccines within a temperature range appropriate to the heat stability profile of tt vaccine. in this study vaccines are transported and stored in the cold chain up to district level. from district to beneficiary level vaccines are exposed to ambient temperatures during a limited period of time. in an initial phase, the stability of 3 lots of tt vaccine kept in ctc is determined. for this, the potency, safety, ph and adsorption of vaccines maintained in ctc will be tested in the laboratory and compared to vaccines that have been maintained in cold chain. if all parameters (i.e. potency, safety, ph and adsorption) are above who specifications the strategy in ctc will be used. only if the laboratory results are adequate, villages will be assigned to one of the vaccination strategies. all women between 14 to 49 years of age in the selected villages who fulfill the inclusion criteria will be invited to participate. in order to determine the baseline anti-tetanus protection, tt vaccination history will be collected from all participants using a standardized questionnaire. women who have already received at least 2 doses of tt vaccine will be excluded from the study. moreover, blood will be collected from all participants to later verify in laboratory the baseline protection. a first dose of tt vaccine will be given according to the assigned strategy (ctc or cold chain). four weeks after the 1st vaccination, a second tt vaccine will be given using the same strategy employed for the first dose. finally, four weeks after the second dose, a blood sample will be collected from all participants who received two doses of vaccine. the serological responses will be compared in the group that received two doses of tt vaccine maintained in cold chain ant the group that received two doses of vaccine maintained in ctc.


Eligibility criteria:
inclusion criteria: * women aged between 14 to 49 years of age * living in the district of moïssala, chad * have no proof of previous vaccination or previous vaccination is not greater than 1 dose of vaccine * previous dose received more than 1 month before * consented to be included in the study exclusion criteria: * allergic reaction to previous tetanus vaccination * severe febrile illness * have received a tetanus vaccine within the previous month * refuses vaccination or does not consent * nomadic population travelling before the end of the study * pregnant women due to deliver within 2 weeks

Keywords: controlled temperature chain outside the cold chain vaccination prevention of mother to child transmission
art and science of human flourishing microsupport study

Conditions: Mental Stress

Summary: the purpose of this study is to determine whether providing small amounts of digital support impacts students in the art and science of human flourishing (ashf) course. approximately 300 participants will be enrolled and can expect to be on study for up to 4 months.

participants will be currently enrolled students in the ashf course. students will complete measures at baseline, daily during the 1-month intervention period, at post-treatment, and 3 months later. during the 1-month intervention period, half of the participants will be randomized to receive small amounts of digital support in the form of text messages. context (from the course website): the art and science of human flourishing course is taught in tandem with the healthy minds program (hmp) app. the overall framework of the ashf course largely aligns with the hmp app and is composed of the following modules and sub-themes which are covered throughout the course of a 15-week semester: foundations: flourishing, transformation, resilience * awareness: focus, emotions, mindfulness * connection: interdependence, compassion, diversity * wisdom: identity, values, gratitude * integration: courage, community small amounts of digital support will be tested on half the participants. primary outcomes for measuring the effect of this support will be the promis depression and anxiety measures.

Eligibility criteria:
inclusion criteria: * currently enrolled in ashf course exclusion criteria: * n/a

Keywords: wellbeing digital support microsupport text messages
trehalose in subjects with neuronal ceroid lipofuscinoses

Conditions: Neuronal Ceroid-Lipofuscinoses

Summary: neuronal ceroid lipofuscinoses (ncl) or batten's disease are the most common juvenile neurodegenerative disease, characterized by early blindness, movement disorders, cognitive and behavioral impairment, epilepsy, and retinopathy. this study aims to collect clinical and laboratory data of patients with ncl taking trehalose.

this study aims to collect clinical and laboratory data of patients with ncl taking trehalose.

Eligibility criteria:
inclusion criteria: * ncl genetic diagnosis (mutation in genes cln3 or cln6) * signed informed consent exclusion criteria: * other concomitant neurodegenerative diseases. * therapeutic and eating changes in the last four months prior to the study * unstable clinical conditions (myoclonus worsening, instability in sleep, parenteral nutrition) * refusal to sign the informed consent

Keywords: juvenile neuronal ceroid-lipofuscinoses unified batten disease rating scale
stress urinary incontinence of sporting teenager

Conditions: Urinary Incontinence, Stress

Summary: physical activity and sport are beneficial to the cardiovascular system, the musculoskeletal system and many chronic pathologies. the high authority of health (has) recommends a regular practice. however, depending on the discipline and level of practice, it may be responsible for traumatic injuries, degenerative musculoskeletal injuries, overtraining, eating disorders or cardiovascular events. it also promotes urinary stress incontinence, by increasing intra-abdominal pressure in some situations. the prevalence of urinary leakage in the athlete depends of the practiced physical activity. a classification of the sports activities can be carried out according to the risk of increased pressures on the pelvic floor: * high-risk sports: trampoline (10.17), acrobatic gymnastics, aerobics, athletics (jumping hedges, heights, triple jump), horse riding, basketball, volleyball, handball, martial arts; * moderate-risk sports: tennis, skiing ... * low risk sports: walking, swimming, cycling, rollerblading, golf ... in sports, urinary incontinence also depends of the practiced movements (jumps, abdominal exercises ...), and the occurence of sports activity. this disorder has even become one of the concerns of federal sports authority (insep). however, there is no data regarding stress incontinence of sports teenagers found n the literature on


Eligibility criteria:
inclusion criteria: * between 10 and 18 years * consultation in medical sporting center exclusion criteria: * urge incontinence

Keywords: adolescent sports
easy way of choosing rectangular expander and getting maximum benefit from expanded tissue

Conditions: Burn Scar; Scalp Wound

Summary: background: tissue expanders are widely used for reconstruction of tissue defects. the choice of expander and planning the flap is complicated for the inexperienced surgeon. objective: to demonstrate the choice of expander sizes proper for the tissue defect and maximum advancement technique during the defect coverage. methods: the present study included 19 patients who were operated between january 2013 and january 2017. the expander projection was chosen in the manner that it would be more than the half length of the defect to be occurred and the expander width was chosen as wide as possible based on the area of its placement. after the expansion was completed, advancement method was used to cover the defect.


Eligibility criteria:
inclusion criteria: * patients treated with rectangular tissue expanders. * patients who attended to at least postoperative six months control. exclusion criteria: * patients treated with tissue expanders other than rectangular expanders. * patients who did not attend to postoperative controls.
educ'avk: recommendations for the antivitamin k's gestion

Conditions: AVK Treatment

Summary: the objective of the project "educ'avk", is to document the efficacy of a strategy combining a specific follow up-notebook and education of attending patient with a pedagogic support, comparatively to an usual education on the impact of clinical events at three months (minor or major hemorrhagic events + recurrence of thrombi-embolic's disease).

standard strategies for the implementation of recommendations are exclusively focused on practitioners. but often they do not appear to be effective (insufficient time accorded per patient, lack of training...). however some qualitative surveys have shown the benefit of a greater role on the part patient in the process of transmitting recommendations through the practitioner. in this study, patient education is begun by the angiologist or a pharmacy student under the responsibility of the hospital investigator. follow-up is realized by the patient's general practitioner. more patient involvement in the realization of the recommendations could increase the proportion of practitioners who follow the recommendations and decrease the iatrogenicity of antivitamin k (avk).

Eligibility criteria:
inclusion criteria: * able to receive benefit sanitary educational act * able to be followed up during three months * acute episode of a venous's thrombi embolic illness (venous's thrombosis distal or proximal deep and/or lung embolism) * a.v.k. treatment for a period of at least three months * return to residence (included return to retreat residence no medicalize) * informed consent form signed exclusion criteria: * distal venous thrombosis limited muscular vein without lung embolism * contra-indication of to an a.v.k. treatment * difficult comprehension of the french language * trouble of visual acuity * trouble of superior function incompatible with an educational's act sanitary * psycho-social instability incompatible with a regular follow-up of three months (without fixed residence, addictive lapsed) * impossibility to return to residence (the return in retreat residence no medicalize is considered as a return to residence) * psychiatric pathology not compensated * life expectancy less than three months * refusal of participation in the study * participation in another clinical study * anterior inclusion in the study

Keywords: therapeutic education thrombi embolic disease
placenta accreta spectrum topographic classification

Conditions: Placenta Accreta

Summary: the present study is a prospective multicenter study consisting of a cohort of patients with prenatal or intraoperative diagnosis of pas, evaluating the clinical outcomes of the group of patients found in each category of the topographic classification. in addition, an approach to evaluate the acceptability of this classification among the obstetrician-gynecologists of the participating medical centers will be included.

the aim of this study is to describe the demographic and clinical characteristics of patients with a diagnosis of placenta accreta spectrum, and to determine the correlation between the topographic classification and the clinical outcomes found in the study. finally, to evaluated whether the proposed classification is accepted by the obstetrician-gynecologists of the participating centers that manage placenta accreta spectrum patients. it is an observational, multicentric study of a prospective cohort, in which data will be obtained from the medical records and other documents in each participating center, which are considered to be of routine use in day-to-day clinical practice. the study of the outcomes proposed in this protocol will be limited to those recorded in the clinical records and will be taken into account until the participant is discharged from the hospital, during which a surgical intervention was performed due to the suspicion or diagnosis of pas. it is projected that the period of patient enrollment will last 2 years, counting on from the first participant included. the study population is pregnant patients with a diagnosis of placenta accreta spectrum who visits any of the participating medical centers, and also obstetrician-gynecologists working in participating medical centers. the centers invited to participate are hospitals or clinics that already have knowledge in how to apply the surgical staging of pas, and the topographic classification and have experience using it.

Eligibility criteria:
inclusion criteria: * pregnant woman over 18 years old. * prenatal diagnosis by ultrasound or mri of placenta accreta spectrum (pas), regardless of the suspected degree of severity of the disease. * case requiring surgical management, either as scheduled or emergent procedure. * application of the topographic classification of placenta accreta spectrum during laparotomy. exclusion criteria: * none.

Keywords: pregnancy outcomes topographic classification placenta accreta
assessment of the effects of different implant abutment occluding materials on dental implant health parameters and microbiology

Conditions: Peri-Implantitis; Dental Implant Failed; Dental Implant Failure Nos

Summary: the primary purpose of this study is to determine what effect, if any, do different dental materials used to seal the prosthetic screw channels of implant supported restorations have on dental implant health parameters and microbiology.


Eligibility criteria:
inclusion criteria: * fully edentulous patient * patient has at least one arch restored with a full-arch dental supported prosthesis exclusion criteria: * poor oral hygiene and motivation (as determined with prosthesis in place) * uncontrolled diabetes * pregnant or lactating * substance abusers * current smokers * psychiatric problems or unrealistic expectations * acute infection in the area intended for implant sealing * positive to hiv and hepatitis b and c * affected by autoimmune diseases * under chronic treatment with steroids or non-steroidal anti-inflammatory drugs.
digitally enhanced smoking cessation for high risk smokers

Conditions: Smoking; Smoking Cessation; Lung Cancer Screening; Smoking, Tobacco; Smoking Behaviors

Summary: this is a research study, is testing a program to improve lung health through smoking cessation and providing education around lung screening. in this research study involves studying the enhanced smoking cessation approaches to promote empowerment (escape) program compared to usual care. the escape program was developed help women with hiv quit smoking. women in the escape program quit smoking and stayed quit for longer (up to 3 months). for this study, investigators have added a lung screening to the escape program and want to test if this will improve lung health through increasing quit rates and lung screening. .

* this is a research study, is testing a program to improve lung health through smoking cessation and providing education around lung screening. the research study procedures include: screening for eligibility and study interventions including participation in counseling and completion of questionnaires by e-mail, phone or in-person. * this research study involves participating in either the enhanced smoking cessation approaches to promote empowerment (escape) program or the usual care. participants will be randomized into one of two groups: * escape: the escape program provides 8 counseling sessions over the phone, provides nicotine replacement therapy at no cost, and education about lung screening * usual care: the usual care program will include 1 counseling session, nicotine replacement therapy at no cost referral and enrollment in quitworks * participants will be in this research study for up to 6-months. * it is expected that about 250 people will take part in this research study.

Eligibility criteria:
inclusion criteria: * 55 to 77 years of age * no previous history of lung cancer * ecog performance status \< 2 * ≥ 30 pack year smoking history * smoke ≥ 5 cigarettes/day * own a mobile phone with access to a video call application * has a primary care provider (pcp) * provide contact information for the pcp * active health insurance * has not had ldct screening * english speaking * can complete an interview exclusion criteria: * hospitalization for severe mental illness within the last year. * the following special populations will not be included * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners

Keywords: smoking smoking cessation lung cancer screening smoking, tobacco smoking behaviors
classical trigeminal neuralgia and sodium channel mutations

Conditions: Trigeminal Neuralgia

Summary: the most common cause of trigeminal neuralgia is considered to be a neurovascular contact. however, this etiological factor only seem to be present in half of the patient group. thus the etiology of the other half is unknown. gain-of function genetic mutations in voltage gated sodium channels have been hypothesized as playing a role in the etiology of trigeminal neuralgia but it has yet to be confirmed. in recent years gain-of-function mutations have been identified as a causative factor in other pain-diseases presenting with trigeminal neuralgia phenotypic similarities.

the aim of this study was to indentify vgsc gene mutations, specifically scn9a, scn10a and scn11a genes, in a group of well characterized trigeminal neuralgia patients. setting: the study will be conducted at the danish headache center, rigshospitalet - glostrup, denmark (inclusion of patients and written informed consent, patient interview, phenotyping/diagnosis, neurological examination, blood sample. departments of neurology and clinical genomics of the maastricht university medical center, maastricht, the netherlands: targeted ng sanger sequencing

Eligibility criteria:
3.1. inclusion criteria subjects of both sexes with tn must meet the following inclusion criteria to be eligible for participation: 1. patients must be able to give signed informed consent prior to study entry 2. patients fulfilling of the ichd-3 beta diagnostic criteria for classical tn.1 3. age 18 years or older. 4. age at debut \< 42 years and/or confirmed first-line relative with tn. 5. respond to sodium channel blockers with a 50% reduction of pain intensity evaluated by both the patient and the examining physician using the visual analog scale (vas). 3.2. exclusion criteria subjects will be excluded if one of the following exclusion criteria is met: 1. psychiatric or mental illness of physical condition that might interfere with the ability of the patients to fill in the informed consent and questionnaires. 2. history of herpes zoster in the distribution of the trigeminal nerve ipsilateral to pain, multiple sclerosis or a space-occupying lesion. 3. history indicative of painful posttraumatic trigeminal neuropathy such as previous trauma, surgery or radiation to the trigeminal nerve ipsilateral to pain.

Keywords: genetic mutations, voltage gated sodium channels, phenotype,
optimal timing of corticosteroids in early-onset fetal growth restriction: the opticore study

Conditions: Fetal Growth Retardation

Summary: the aim of this observational study is to optimize the timing of antenatal corticosteroids administered to patients with pregnancies complicated by early-onset fetal growth restriction in order to reduce neonatal morbidity and mortality. in the netherlands two main timing strategies of antenatal corticosteroids are commonly practiced. in this study the investigators will compare these two timing strategies regarding ccs administration in early-onset fgr on the combined endpoint of perinatal, neonatal and in-hospital mortality. in addition, the investigators aim to develop a dynamic, prediction tool, a novel technique in prediction research to predict the time-interval in days until delivery within this population. with that, the investigators aim to reduce neonatal morbidity and mortality for future fgr pregnancies.


Eligibility criteria:
inclusion criteria: * early-onset fgr in accordance with the consensus-based definition of gordijn et al. (19); * singleton pregnancy; * age ≥ 18 years; * installed active, neonatal management after counselling (thus having an indication for ccs administration in case of birth \< 34 weeks of gestational age). exclusion criteria: * multiple pregnancies; * fetal congenital abnormalities or antenatal diagnosed genetic disorders; * patients who stated that their patient or offspring data may not be used for scientific research.

Keywords: fetal growth restriction retrospective cohort study antenatal corticosteroids dynamic predictive tool
direct anterior approach for femoral neck fractures

Conditions: Femoral Neck Fractures

Summary: the primary objective is to examine if in patients with a dislocated femoral neck fracture who receive a total hip arthroplasty, direct anterior approach will give a better result in terms of mobilization, function and pain in the first weeks and months postoperatively, than direct lateral approach.

first included patient 23th november 2018

Eligibility criteria:
inclusion criteria: * dislocated femoral neck fracture exclusion criteria: * infection around the hip (soft tissue or bone) * pathologic fracture * excessive alcohol or substance abuse that most likely will give reduced compliance * patients with any fractures of the long bones in the lower extremity, fracture of the spine, and/or intra-thoracic or intra-abdominal injury (i.e., multiple trauma). because the outcomes and clinical course of patients with multiple trauma may be quite different from a non-trauma patient. * bedridden patients/non-walkers * patients with an underlying illness that doesn't have life expectancy beyond six months * in case of severe cognitive impairment where the patients are not able to give their informed consent

Keywords: arthroplasty, replacement, hip orthopedic procedures
myeloproliferative neoplastic diseases observatory from brest

Conditions: Polycythemia Vera; Essential Thrombocythemia; Primary Myelofibrosis

Summary: all patients diagnosed or followed in brest university hospital for philadelphia negative myeloproliferative neoplasms will be included in this observational study. myeloproliferative neoplasms recorded included: polycythemia vera, essential thrombocythemia and primary myelofibrosis. this is a not interventional study. alive patients need to sign a non-opposition consent form. patients will be followed until last news (death, change of reference centre...).

in this retrospective and prospective study, clinical and biological data from diagnosis until last news will be recorded. clinical data collected: patients and disease characteristics at the time of the diagnosis, disease and mutational status, cardio-vascular risk factors, history of thrombosis and cancer. biological data collected: hemogram and bone marrow results if available. during the follow-up new data will be noted: treatment changes (reasons of change and type of drug), thrombotic events (localization, date and hemogram), phenotypic evolutions (type and date), death (date and etiology).

Eligibility criteria:
inclusion criteria: * patients with essentiel thrombocythemia, polycythemia vera or primary myelofibrosis * signature of the non-opposition consent form exclusion criteria: * none