Kornimate/medical-research-clean huggingface dataset:
using tea-based mouthwash relieve stomatitis and oral ulcers

Conditions: Stomatitis

Summary: the aim of this study is to use a tea-based mouthwash to relieve pain and discomfort in patients with stomatitis and ulcers.

the objective of this study is to use tea as a base, supplemented with licorice to reduce bitterness and astringency, to make mouthwash, and use tea's antioxidant and anti-inflammatory properties to relieve the pain and discomfort of stomatitis and ulcer patients. this study will observe the difference between saliva and oral mucosal cells before and after treatment, to find the mechanism of effective treatment of stomatitis.

Eligibility criteria:
inclusion criteria: age over 20 years old, male or female exclusion criteria: patients with oral cavity cancer, oropharyngeal cancer, and active bacterial infection.

Keywords: stomatitis; oral ulcers; oral mucosa; tea; mouthwash
the impact of nutritional service in the stone clinic on the patient urine collection results

Conditions: Kidney Stone; Kidney Calculi

Summary: kidney stone disease has become a common phenomenon in the us and europe with a growing incidence of about 10%. life style and dietary changes have a cardinal part in kidney stone prevention. therefore it was only natural to determine the impact of the addition of a nutritionist to a stone clinic run by a urologist and a nephrologist.

kidney stone disease has become a common phenomenon in the us and europe with a growing incidence of about 10%. a history of kidney stone disease has also been connected to cardiovascular and renal insufficiency events to a point that kidney stones is looked at today as a systemic predictor of hypertension, cardiovascular disease and more. seeing the importance of these risk factors we initiated a stone clinic for our kidney stone patients several years ago run jointly by a urologist and a nephrologist. seeing that life style and dietary changes have a cardinal part in kidney stone prevention, it was only natural to determine the impact of the addition of a nutritionist to a stone clinic run by a urologist and a nephrologist on our patient parameters.

Eligibility criteria:
inclusion criteria: * 18 yo and older * 2 kidneys * kidney or ureteric stone treated surgically or conservatively exclusion criteria: * single kidney * aberrant kidney anatomy

Keywords: kidney stone kidney caliculi
eras and pediatric scoliosis surgery

Conditions: Scoliosis

Summary: the aim of this study is to compare the outcomes after scoliosis surgery before and after eras (enhanced recovery after surgery) program inplementation in children and teenager.

enhanced recovery after surgery (eras) is a multimodal approach focused on reducing the stress response and associated physiologic changes related to surgery. over the past 20 years, eras programs have been found to result in reduced lenght of stay and complications in adult patients. data in pediatric population remains very scarce.therefore this study was designed to compare the outcomes after scoliosis surgery before and after eras (enhanced recovery after surgery) program inplementation in children and teenager.

Eligibility criteria:
inclusion criteria: * patient with age \< 18 years * patient scheduled for scoliosis surgery exclusion criteria: * patient with age \> 18years * patient with medical follow up by pediatric chronic pain departement

Keywords: pediatric surgery rehabilitation
evaluation of new biomarkers in stage 3 and 4 endometriosis

Conditions: Endometriosis

Summary: the diagnostic value of annexin v, svcam-1, sicam-1, vascular endothelial growth factor and proinflammatory cytokines (tnf-a and interleukin-6) in ovarian endometriosis and deep infiltrating endometriosis, their levels in organ-specific involvement, their relationship with symptoms, and the changes of these markers in the postoperative period will be evaluated.

serum annexin v, svcam-1, sicam-1, vascular endothelial growth factor and proinflammatory cytokines (tnf-a and interleukin-6) values were studied by taking blood samples from all patients before and three months after the operation.

Eligibility criteria:
inclusion criteria: 1. stage iii and iv endometriosis patients requiring surgery due to chronic pelvic pain or suspected malignancy exclusion criteria: 1. malignant disease 2. ovarian failure 3. acute pelvic inflammatory disease 4. smokers 5. pregnancy 6. chronic autoimmune disease
transcatheter arterial micro-embolization (tame) using nexsphere-f in patients with knee degenerative osteoarthritis

Conditions: Osteoarthritis

Summary: among knee degenerative osteoarthritis patients aged 50 or older, it will prove the therapeutic effect and safety of nexsphere-f embolization for patients who need additional treatment because pain is not controlled even if conventional treatments are taken.

this clinical trial is a single arm, single center, open label, and pilot clinical trial to prove the performance and safety of nexsphere-f in patients over the age of 50 who need additional treatment because pain is not controlled even after conventional treatments are taken. since consent cannot be obtained during surgery from a subject who meets the inclusion and exclusion criteria, a written consent is obtained in advance between four weeks before the procedure and the day. as one of the usual orthopedic evaluations, baseline mri will be performed and worms will be evaluated. in addition, the womac score and the vas score will be measured before the procedure and used as a baseline for evaluation variables. since it is a pilot study to evaluate the validity, all subjects will undergo a transcatheter arterial micro-embolization (tame).

Eligibility criteria:
inclusion criteria: * those who fall under kellgren-lawrence grade 2 to 3 according to the criteria in accordance with acr guidelines and x-ray findings used within 12 months * vas score exceeding 50mm * an adult male and female over 50 years of age * preservative therapy glucosamine chondroitin sulfate/physiological therapy and rehabilitation exercises, and joint injections of hyaluronic acid for more than 12 weeks * a person who agrees to maintain existing medication treatments during the clinical trial period but does not receive additional medication or new conservative treatments for knee osteoarthritis pain management. exclusion criteria: * a locally infected patient * a person whose life expectancy is less than six months * a person with symptoms of lower extremities that are considered secondary to atherosclerosis or arterial vascular disease (ex: claudication ischemic rest pain) * a person diagnosed with rheumatism or infectious arthritis * a person who has undergone knee arthroplasty * a person who has not had knee microfracture surgery for more than 10 years * inr 2.5 or less than 30,000 platelets * anaphylaxis-causing iodine allergy * patients with renal dysfunction or impaired renal function who have been diagnosed with less than 45 gfr (egfr) within the last 60 days * those who have a taboo on mr videos * pregnant women * other cases where it is deemed inappropriate to participate in this clinical trial at the discretion of the researcher
testing four feeding approaches to oral feeding in preterm infants

Conditions: Preterm Infant

Summary: the purpose of this study was to test the effect of four randomly assigned approaches to oral feeding transition on feeding outcomes in preterm infants.

the study is completed.

Eligibility criteria:
inclusion criteria: * 1) the infant's gestational age at birth was less than 32 weeks; 2) the infant was receiving enteral feedings every three hours; 3) the infant was able medically to feed orally by 32 weeks post-menstrual age (pma); and 3) the parents gave consent for the infant's participation. exclusion criteria: * 1) they were unable to begin oral feeding at 32 weeks pma due to gastrointestinal, craniofacial, cardiovascular, neuromuscular, and/or genetic defects; 2) had surgical necrotizing enterocolitis; or 3) needed ventilator support, including nasal continuous positive airway pressure (cpap), beyond 32 weeks pma. infants receiving oxygen by cannula were included.

Keywords: infant feeding
the effect of honey on lessening the withdrawal symptoms

Conditions: Smoking Cessation; Withdrawal Symptoms

Summary: this project investigates the effect of honey on lessening the withdrawal symptoms according to the body constitution.


Eligibility criteria:
inclusion criteria: * the cessation clinic patients aged more than 18 * only take champix for smoking cessation exclusion criteria: * diabetes, cancer, renal disease * with wet and hot body constitution * allergic to honey * accepting traditional chinese medicine intervention
a mobile mindfulness programme for individuals/couples experiencing fertility problems

Conditions: Infertility

Summary: infertility and its treatment result in a considerate emotional burden and a recent guideline of the european society of human reproduction (eshre) highlight the importance to support couples facing fertility problems. mindfulness-based programs (mbps) have been proven effective in improving well-being and combatting mood disturbances in a wide range of conditions in both treatment and prevention. the overall aim of this project is to evaluate the impact of a mobile mindfulness programme (mmp) on quality of life and emotional well-being in individuals/couples experiencing fertility problems. the present study is a two-group randomized controlled trial with assessments at baseline, at 1,5 months and at 3 months. sixty couples experiencing fertility problems will be enrolled. they will be assigned to either an intervention group (immediate access to the mmp) or a control group (waitlist condition). the mobile mbp is developed by a team of experienced mindfulness trainers, clinical psychologists, and a psychiatrist and adheres to a standardized protocol. the primary outcomes will be quality of life and emotional distress. secondary outcomes will be repetitive negative thinking, self-compassion and mindfulness skills. additionally, the feasibility of the mmp will be evaluated.


Eligibility criteria:
inclusion criteria: * individuals/couples experiencing fertility problems (using the criteria for the definition of 'infertility', as in: the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse) (zegers-hochschild et al., 2017) * both partners possess a smartphone * both partners understand and speak dutch * written informed consent after been informed on all aspects of the study exclusion criteria: not applicable

Keywords: infertility mobile health mindfulness
enhancing postpartum discharge instructions

Conditions: Health Literacy; Randomized Controlled Trial; Postpartum; Cesarean Delivery Affecting Newborn

Summary: post-cesarean delivery discharge instructions are not currently at an appropriate health literacy level. enhancing discharge instructions with a visual aid did not improve scores on comprehension quizzes, either immediately or two-weeks post-discharge. however, participants preferred to have access to visual images with discharge instructions.

objective: to evaluate the effect of a visual aid on improving comprehension of hospital discharge instructions for cesarean wound care. methods: a randomized control trial with a 1:1 allocation ratio and an intention to treat analysis was performed at an urban, tertiary care center from june-november 2017. fifty english-speaking patients ages 18-50 who had undergone a cesarean delivery were randomized to receive either standard or enhanced discharge instructions regarding post-cesarean incision care. enhanced instructions included a visual aid not present in the standard instructions. participants completed a comprehension quiz prior to hospital discharge and again 2 weeks after discharge as well as the realm literacy assessment prior to discharge.

Eligibility criteria:
inclusion criteria: * able to consent * identified as english speaking * had a cesarean delivery during the index hospitalization for delivery of their living newborn exclusion criteria: * non-english speaking * declined to participate * required a translator for communication * intellectual disability (as self-identified or as determined by healthcare provider) * currently incarcerated
scoring clinical index for onychomycosis in toenail onychomycosis treating with itraconazole capsules

Conditions: Onychomycosis, Toe

Summary: the purpose of this study is to evaluate the participants with toenail onychomycosis (fungal infection of the nail) confirmed positive by potassium hydroxide (koh) and bacterial identification test after administration of itraconazole (icz) capsule, to identify the change in scoring clinical index for onychomycosis (scio) score and to determine the relationship between the change of scio score and mycological cure rate and clinical improvement.

this is an open-label (all people know the identity of the intervention), multicenter (when more than one hospital or medical school team work on a medical research study) study of icz in participants with onychomycosis. the present study consists of 2 periods: screening period (up to week minus 2) and treatment period (up to week 49). the icz will be administered in 3 cycles (week 1, week 5 and week 9) and each cycle will consist of taking 2 capsules of 100 milligram (mg) each, orally, twice daily, continuously for 1 week. total duration of treatment will be of 49 weeks. efficacy will primarily be evaluated by percentage of participants showing 10 percent or higher response in scio score. participants' safety will be monitored throughout the study.

Eligibility criteria:
inclusion criteria: * onychomycosis participants whose etiologic agent is identified by potassium hydroxide (koh) smear and bacterial identification test * participants with scoring clinical index for onychomycosis (scio) greater than or equal to 9 * participants who are healthy in general in following items: medical and medication history, physical examination before administration time, vital signs (blood pressure and pulse) and clinical laboratory tests (clinical test results \[liver function and renal function\] are within 2 times the normal range) * female participants of child-bearing age who use acceptable contraceptives * participants who can understand features of clinical study and signed informed consent form exclusion criteria: * participants with psoriasis (scaly skin rash) * diabetic participants who take an anti-diabetic drug * pregnant or breast feeding female participants * participants with clinical evidence of arterial insufficiency or peripheral vascular disease and medical history of decreased ventricular function like congestive heart failure (heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body) * participants who applied a topical antifungal agent (nail lacquer) on target nail within 1 month before the study medication administration and who took an oral antifungal agent within 3 month before the study medication administration

Keywords: onychomycosis, toe itraconazole sporanox
usefulness of icg angiography-guided thyroidectomy for preserving parathyroid function

Conditions: Iatrogenic Hypocalcemia

Summary: transient and/or permanent hypoparathyroidism is the most frequent complication after total thyroidectomy. the identification of the parathyroid glands and a correct dissection during thyroidectomy have been postulated as key factors for their preservation and, consequently, to prevent hypoparathyroidism. the use of indocyanine green (icg) fluorescence has reliably predicted parathyroid glands functionality in the immediate postoperative period. recently, it is proposed that showing the vascular map of the parathyroid glands before performing the thyroidectomy by means of icg angiography prevent the development of postoperative hypoparathyroidism. the goal of this multicentric study is to demonstrate that the preservation of the function of parathyroid glands is greater with use of arteriography than without. patients will be divided in two groups. in the study group, the vascular map with icg of parathyroid glands will be showed before performing the lobectomy. once the lobectomy is done, the function of the glands will be assessed. whereas in the control group, arteriography with icg will only be carried out in order to check their function at the end of the lobectomy. researchers will compare the study group and the control group to see which one present the lowest taxes of postoperative hypoparathyroidism.

to assess the appearance of postoperative hypoparathyroidism, a systematic determination of pth and corrected calcium values will be carried out the morning after the intervention. it will be considered that there is hypoparathyroidism when the patient presents symptoms of hypocalcaemia, when he has required the administration of calcium and/or vitamin d prior to this determination or when he presents corrected calcium values \< 1.8 mmol/l.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age with a surgical indication for total thyroidectomy with or without central cervical lymph node dissection due to thyroid pathology. * the patient or their guardian, where applicable, has the capacity to understand the study and agrees to participate in it, signing the corresponding informed consent document. exclusion criteria: * previous surgical intervention on the thyroid or parathyroid gland. * associated hyperparathyroidism that requires associating a parathyroidectomy in the same surgical act. * patients with contraindications for the administration of icg. * current drug use or alcohol abuse that could interfere with compliance with the study requirements. * participation in any other drug trials in the month prior to randomization.

Keywords: hypocalcemia icg angiography guided thyroidectomy
efficacy and safety of fermented barley on decrement of body fat in obese subjects

Conditions: Overweight; Hyperlipidemia

Summary: barley, like oats, is a rich source of the soluble fibre β-glucan, which has been shown to significantly lower ldl-cholesterol (ldl-c). however, barley foods have been less widely studied.

this study investigated whether the supplementation of barley β-glucan is reduce the visceral fat as well as the serum low-density lipoprotein cholesterol (ldl-c) and total cholesterol (tc) in mildly hypercholesterolemic subjects. in a 12 week double-blind, controlled study, subjects were randomized to one of treatment group(3.0g/day as β-glucan) or placebo group.

Eligibility criteria:
inclusion criteria: * an age from 19 to 70 years, * a bmi(body mass index) \>23 kg/m\^2, * an ldl-c(low density lipoprotein-cholesterol) concentration between 110 and 250 mg/dl exclusion criteria: * they had heart disease, liver or kidney disease, food allergies, daily exercise habits, a body weight increase or decrease \>10 kg in the previous 3 months, irregular lifestyle habits * they took medication and functional foods known to affect lipid metabolism.

Keywords: soluble fiber polycan overweight ldl-c(low density lipoprotein-cholesterol)
long-term safety evaluation of dupilumab in patients with asthma (liberty asthma traverse)

Conditions: Asthma

Summary: primary objective: to evaluate the long-term safety and tolerability of dupilumab in participants with asthma who participated in a previous dupilumab asthma study (dri12544, pdy14192, efc13579, efc13691). secondary objectives: to evaluate the long-term efficacy of dupilumab in participants with asthma who participated in a previous dupilumab asthma clinical study. to evaluate dupilumab in participants with asthma who participated in a previous dupilumab asthma clinical study, with regards to: * systemic exposure * anti-drug antibodies * biomarkers

a screening period, up to 3 weeks, applied only for participants who came from dri12544 study. the total study duration, per participant, was a maximum of 108 weeks (or 111 weeks considering a maximum screening period of 3 weeks for study dri12544) for the participants enrolled prior to amendment 04 approval and a maximum of 60 weeks for the participants enrolled after amendment 04 approval. following amendment 04 (dated 31 oct 2016) the open-label treatment duration was amended to 48 weeks (1 year); and the 16-week post-treatment period was shortened to 12 weeks.

Eligibility criteria:
inclusion criteria: - participants with asthma who completed the treatment period in a previous dupilumab asthma clinical study (i.e., pdy14192, efc13579 or efc13691) or participants with asthma who completed the treatment and follow-up periods in previous dupilumab asthma study dri12544. exclusion criteria: - participants who experienced any hypersensitivity reactions to investigational medicinal product (imp) in the previous dupilumab asthma study, which, in the opinion of the investigator, could indicate that continued treatment with dupilumab, may present an unreasonable risk for the participant. the above information was not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.
method for improved intraoperative blood loss estimates

Conditions: Improved Intraoperative Blood Loss Estimates

Summary: the purpose of this study is to develop a mathematical algorithm which the investigators plan to use to more accurately estimate intraoperative blood loss.


Eligibility criteria:
inclusion criteria: all elective surgical patients exclusion criteria: 1. age \< 18 2. pregnant women 3. prisoners 4. lack of informed consent 5. attending physician feels enrollment could interfere with optimal patient care 6. patients who did not have a preoperative hemoglobin measured as part of their preoperative work-up 7. patients whose preoperative hemoglobin fraction is abnormal. 8. patients who will likely require an intraoperative blood transfusion. 9. patients for whom the intraoperative use of the cell saver is anticipated.