Kornimate/medical-research-clean huggingface dataset:
covid-19 testing pilot study

Conditions: Diagnostic Test, Routine; Coronavirus; Diagnoses Disease; Rapid Coronavirus Test

Summary: the purpose of this study is to determine the reliability of a low-cost rapid diagnostic test for covid-19. the method of the testing procedure uses electrochemistry to detect covid-19 spike proteins within human samples. to test the effectiveness of this new method, patients will be recruited as they present for testing at ambulatory penn testing sites. patients will be asked to self-collect one anterior nares samples under the supervision of authorized study personnel.


Eligibility criteria:
inclusion criteria: 1. the subject must be an adult (age\>17) and either sex. 2. written informed consent must be obtained prior to study enrollment. a. a subject who is eighteen (18) years or older must be willing to give written informed consent and must agree to comply with study procedures. 3. subject must be able to read and write in english. exclusion criteria: 1. the subject is currently receiving or has received within the past thirty (30) days of the study visit an experimental biologic, drug, or device including either treatment or therapy. 2. the subject has previously participated in this research study.

Keywords: covid-19 detect pandemic symptomatic asymptomatic anterior nares
central obesity and hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma; Obesity; Microwave Ablation

Summary: recurrence and metastases after microwave ablation(mwa) of hepatocellular carcinoma(hcc) are the major factors that influence the survival. obesity has been reported was significantly correlated with increased risk of developing hcc. in this study, we will analysis the association of multiple obesity index(waist circumference,waist-hip ratio and body mass index) with the prognosis of hcc treated by mwa.


Eligibility criteria:
inclusion criteria: * absence of ascites or the depth of ascites on us detection less than 4 cm; * a normal serum total bilirubin level or less than 60 µmol/l; * a normal albumin level or not less than 30 g/l; * for radical treatment, single lesion of 8 cm or smaller, three or fewer multiple lesions with a maximum diameter of 4 cm or less, absence of portal vein cancerous thrombus or extrahepatic metastases; * for palliative treatment, those with large or multiple lesions, suffering multiple metastases and unsuitable for other modalities can be considered to undergo the mwa on the condition of good hepatic function and blood coagulation function to tolerate the procedure. exclusion criteria: 1. clinical evident liver failure, such as massive ascites or hepatic encephalopathy or with a trance-like state 2. severe blood coagulation dysfunction (prothrombin time of more than 30 seconds, prothrombin activity less than 40%, and platelet count less than 30 cells×109/l) 3. high intrahepatic tumor burden (tumor volume \>70% of the target liver volume or multiple tumor nodules) or high extrahepatic tumor burden 4. acute or active inflammatory and infectious lesions at any organ 5. acute or severe chronic renal failure, pulmonary insufficiency or heart dysfunction 6. relative contraindication concerns medical risk for the tumor proximity to diaphragm, gastrointestinal tract, gallbladder, pancreas, hepatic hilum and major bile duct or vessels, which may require adjunctive techniques to prevent off-target heating of adjacent structures during the ablation procedure.
status asthmaticus on the intensive care prospective - static pro

Conditions: Childhood Asthma With Status Asthmaticus

Summary: this study will prospectively assess the impact and relevance of several risk factors for children with severe acute asthma (saa) or acute wheeze that have been identified in retrospective studies. secondary we will assess short-term medical and psychosocial functioning in patient (and parents) admitted to a picu for saa/acute wheeze versus a control group admitted to a mc for saa/acute wheeze.


Eligibility criteria:
inclusion criteria: * between 2 and 18 years of age * admission to a picu for saa or acute wheeze or admission to a mc for saa or acute wheeze exclusion criteria: * patient is outside of specified age range * down's syndrome * congenital/acquired heart defect that interferes with normal saa treatment * congenital/acquired airway defect (tracheomalacia/bronchomalacia) * primary/secondary immunodeficiency * pre-existing chronic pulmonary condition, known to mimic asthma: cystic fibrosis, bronchopulmonary dysplasia, bronchiolitis obliterans * if both parents are not able to speak the dutch language

Keywords: short-term medical and psychosocial functioning
a study to evaluate efficacy and safety of qingzhu granules in the treatment of acute gouty arthritis

Conditions: Gouty Arthritis

Summary: this study will evaluate the efficacy and safety of qingzhu granules in the treatment of acute gouty arthritis ( damp heat pattern)


Eligibility criteria:
inclusion criteria: 1. male and female patients aged 18 to 70 years. 2. patient meeting the acr/ eular 2015 gout classification criteria. 3. patient meeting the damp heat pattern identification of the traditional chinese medicine. 4. onset of current flare within 48 hours. 5. patient-reported, current ongoing flare of gouty arthritis characterized by baseline pain intensity in the index joint of ≥40 mm on a 0-100 mm vas. 6. signed informed consent to participate in this study. exclusion criteria: 1. secondary gouty arthritis ( caused by other diseases or drugs). 2. the presence of pain symptoms caused by other diseases, as judged by the investigator, may have an impact on the safety or effectiveness evaluation. 3. if there are severe motor, digestive, respiratory, urological, reproductive, endocrine, immune, neurological, circulatory, or psychiatric disorders, the investigator may determine that it may have an impact on the safety or effectiveness evaluation. 4. abnormal liver function (glutamic-oxaloacetic transaminase or glutamic-pyruvic transaminase\>2 uln) or abnormal renal function (blood creatinine\>uln). 5. people who are not eligible for vas evaluation, such as those with severe impairment of abstract ability, visual and writing function, and those who have taken sedatives. 6. patients who have undergone uric acid lowering treatment but have not stably used uric acid lowering drugs within the 2 weeks prior to randomization. 7. after this gout attack, traditional chinese medicine, chemical drugs (including but not limited to colchicine, glucocorticoids, and adrenocorticotropins), biological drugs (including but not limited to il-1 and tnf- α inhibitor) ,and non drug treatment (including but not limited to acupuncture and moxibustion and topical ice)that have therapeutic effects on gout have been used. 8. after this gout attack, non-steroidal anti-inflammatory drugs (including but not limited to aspirin, acetaminophen, losoprofen, ibuprofen, and diclofenac sodium) have been used, and the medication duration is within 5 half-lives of the drug. 9. known allergies to the drug components of this study. 10. contraindications to diclofenac sodium enteric coated tablets. 11. men or women who have plans for conception within 3 months after the start to the end of the study. 12. pregnant and lactating women. 13. participated in other clinical trials within the past month. 14. other situations that the investigator determines are not suitable for enrollment.
repetitive behavior disorders in people with severe mental retardation

Conditions: Mental Retardation; Stereotyped Behavior; Self-Injurious Behavior; Compulsive Behavior

Summary: repetitive behavior disorders are prevalent among people with severe mental retardation. these disorders can interfere significantly with an individual's daily functions. this trial is part of a long-term project that has studied the biologic basis of and possible treatments for repetitive behavior disorders. the trial will evaluate the effectiveness of two medications, a selective serotonin reuptake inhibitor (ssri) and an atypical antipsychotic, in treating repetitive behavior disorders in people with mental retardation.

abnormal repetitive behaviors (odd or inappropriate movements, self-injury, and compulsions) are among the aberrant behaviors exhibited by individuals with mental retardation. however, little is known about their pathobiology and treatments are largely unconfirmed by controlled trials. for example, few controlled studies have examined the efficacy of pharmacological treatment of abnormal repetitive behavior in individuals with mental retardation. this trial is part of a larger project designed to elucidate the neurobiological bases of repetitive behavior disorders and to develop rational, safe, and effective pharmacological treatments. thus far, the project has established a pathophysiological basis for stereotyped behavior disorder, demonstrated the role of central dopamine deficiency in stereotyped behavior disorder, and provided evidence of the efficacy of both 5-ht uptake inhibitors and atypical antipsychotics in treating stereotyped behaviors. there is currently little information to guide the clinician in deciding which drug class may be more effective for which abnormal repetitive behaviors and for which individuals. moreover, little work has attempted to identify variables that may predict differential treatment response. this trial will assess the relative efficacy of an ssri and an atypical antipsychotic across multiple categories of abnormal repetitive behaviors.

Eligibility criteria:
inclusion criteria * mental retardation * medically stable resident of either western carolina center, morganton, nc or tacachale community, gainesville, fl * free of sensory deficits * ambulatory * high rate of stereotyped behavior that may co-occur with self-injurious or compulsive behaviors exclusion criteria * poor general health * cardiac, hepatic, or renal abnormalities * seizure within 4 months prior to study entry (patients on seizure medication who have not had a seizure within 4 months prior to study entry may participate) * tardive dyskinesia * akathisia * neuroleptic use within 6 months of study entry * history of sensitivity to ergot alkaloids * hypertension

Keywords: repetitive behavior disorder stereotypy sertraline
effects of autogenic and reciprocal inhibition techniques with conventional therapy in mechanical neck pain

Conditions: Mechanical Neck Pain

Summary: the objective of this randomized control trial is to determine the effectiveness of autogenic and reciprocal inhibition techniques with conventional therapy in mechanical neck pain to improve pain, range of motion, and functional disability in long term. this study is being conducted at the physiotherapy department of sindh institute of physical medicine and rehabilitation, karachi (former institute of dow university of health sciences) among 80 patients with mechanical neck pain on the basis of non-probability purposive sample technique with screening for study criteria through a consultant physician (blinded) . after taking informed consent all participants will be randomly allocated in two groups through second researcher who is not involved in screening, baseline assessment and providing intervention. group 1 will receive autogenic inhibition muscle energy technique (met) with conventional therapy and group 2 will receive reciprocal inhibition met with conventional therapy. a total of 12 sessions will be provided. outcomes will be assessed at baseline, after 1st session, and at last session.


Eligibility criteria:
inclusion criteria: * moderate intensity (3.5-7.4cm) pain on vas * limited or painful cervical rom * pain more than 4 weeks (sub-acute and chronic) * 20-50 years age exclusion criteria: * any symptom and sign of radiculopathy and myelopathy * any neurological disease like multiple sclerosis, parkinson or stroke * taking any pain medication * trigger point of upper trapezius * any fracture, surgical procedure, or trauma of the cervical spine * any red flag or signs of serious pathology like rheumatic or inflammatory diseases, malignancy, infection, or vascular disease such as vertebro-basilar insufficiency.

Keywords: neck pain manual therapies therapy-soft tissue muscle stretching exercises
european organisation of research and treatment (eortc) quality of life questionnaire (qlq) breast cancer module update

Conditions: Quality of Life

Summary: the purpose of this study is to update the eortc qlq breast (br)-23 module. since the development of br-23 published 1996 the standard therapy of breast cancer has changed. new therapies brought new side effects and different impact on qol (quality of life) are not sufficiently covered by eortc qlq br-23 and an update of the module could be useful, both from clinical and scientific point of view.

1. based on a systematic literature search a new issue list will be developed, containing additional issues relevant for new treatment strategies. a total of 5-10 patients from different countries (5-8) as well as health care professionals (5/country) will be interviewed (phase 1). 2. operationalization of the issues into items; a provisional version of a the questionnaire and a hypothetic scale structure will be established (phase2). 3. the resulting provisional updated module will be tested with respect to understanding, comprehensiveness and applicability (according to the eortc module development guidelines). the items will be translated from english into other languages following a standardized forward-backward procedure. total aof 260 patients will be interviewed from different cultural areas: northern europe, central europe, southern europe, asia (phase 3). 4. the module and its scale structure will be field-tested in a large, international group of patients in order to determine its acceptability, reliability, validity, responsiveness and crosscultural applicability .

Eligibility criteria:
inclusion criteria: * patients with early or metastatic breast cancer exclusion criteria: * patients with second malignancy

Keywords: breast cancer, quality of life
clinical relevance of intracellular staphylococci in bone and joint infections

Conditions: Bone and Joint Infection; Staphylococcus

Summary: different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal bji, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. the intracellular localization of staphylococci is well documented by in vitro studies, however, few studies have shown the presence of intracellular staphylococci in clinical specimens from patients with bji. the aim of the crisbo study is to document the clinical relevance of intracellular staphylococci in the context of bji. immunostaining targeting staphylococci and components will be carried out on tissue samples taken from patients with bji during their treatment (samples similar to those used for routine diagnosis in pathology). our objectives are to identify whether intracellular staphylococci are observable in these samples and if so, in which cell type (s) are they housed.


Eligibility criteria:
inclusion criteria: * patients having had an osteo-articular infection with staphylococci exclusion criteria: -

Keywords: bone and joint infection staphylococcus intracellulare
mortality of cancer surgery during sars cov2 pandemic

Conditions: SARS CoV 2 Infection; Cancer

Summary: the impact of cancer surgery during covid epidemic is not clear. the published reports show contradictory findings that extend from no change in mortality to increased mortality, further no data on exposure and outcome of health care worker is available. this study is designed to address the above questions

this is a retrospective study from the prospectively collected data that is extracted from the electronic database of department of surgical oncology, ims, bhu the data is inform of two cohorts one extending from april 2019-april 2020 and other from may 2020 to may 2021 i.e. pre covid and during covid pandemic

Eligibility criteria:
inclusion criteria: * all patients operated during the study period exclusion criteria: * none
school based prevention for childhood anxiety

Conditions: Anxiety Disorders

Summary: this study was designed to conceptualize a school-based prevention program or childhood anxiety.

this is a project corresponding to a career development grant. the main goal of the proposed research was to identify potential barriers to implementing a school-based anxiety preventive intervention, identify strategies to overcome these barriers, and use this information to test a school-based indicated intervention for child anxiety.

Eligibility criteria:
inclusion: borderline child anxiety levels based on the spence child anxiety scale exclusion: externalizing problems (based on teacher nominations) more severe than spence child anxiety scale borderline levels
a multi-center study to evaluate the efficacy and safety of pancreatic duct stents placement before the enucleation of insulinoma located in the head and neck of the pancreas near the main pancreatic duct

Conditions: Insulinoma

Summary: the purpose of this study is to compare the clinical efficacy and economic cost of enucleation after placement of pancreatic duct stents before surgery with that of direct enucleation alone, and to evaluate its safety and feasibility.

the research contents of this study include: patients with insulinoma near the main pancreatic duct in the head and neck of the pancreas were randomly divided into two groups: the preoperative pancreatic duct stent enucleation group (stended en), the direct en group (den), the sen group asked a digestive endoscopist to place the pancreatic duct stent before surgery, and the next day or the next day after surgery, and the den group received enucleation directly. the safety of the two groups was compared, including the evaluation of surgical effect postoperative complications and long-term prognosis based on follow-up data analysis; at the same time, the differences between the two groups were evaluated from the perspective of health economics.

Eligibility criteria:
inclusion criteria: * the clinical qualitative diagnosis of insulinoma was clear; * the localization diagnosis was clear, and it was determined that the tumor was single, located in the head and neck; * the distance between the tumor and the main pancreatic duct was determined to be ≤ 2mm by preoperative imaging (enhanced ct, mri, etc.); * truly informed and voluntarily participate in this study. exclusion criteria: * maximum diameter of the tumor \>2cm proved pathologically * severe cardiopulmonary complications before operation * combined with other known tumor diseases * insulinoma is invasive or has suspicious metastatic lesions * previous upper abdominal surgery history * refusal or inability to cooperate in the study

Keywords: pancreatic enucleation pancreatic duct stent regular pancreatectomy health economics evaluation
a phase 2 safety and exploratory skin lesion measurement of tr-701 fa study

Conditions: Major Cutaneous Abscess; Cellulitis; Erysipelas

Summary: characterization of the safety profile of tr-701 free acid (fa) in patients with major cutaneous abscess or cellulitis/erysipelas.

this is an open-label, multicenter study of oral tr-701 fa 200 mg once daily for 6 days for the treatment of major cutaneous abscess or cellulitis/erysipelas in patients 18 years of age or older. this study is designed to further characterize the safety profile and gather additional lesion measurement data of tr-701 fa in patients with major cutaneous abscess or cellulitis/erysipelas.

Eligibility criteria:
inclusion criteria: * male or female patients ≥ 18 years of age * suspected or documented gram-positive infection from baseline gram stain or culture. * cellulitis/erysipelas or major cutaneous abscesses at screening exclusion criteria: * postsurgical or open wound infections * severe sepsis or septic shock * uncomplicated skin and skin structure infections such as furuncles, minor abscesses (\< 75 cm2 or area of suppuration not surrounded by cellulitis/erythema), and impetiginous lesions * infections associated with, or in close proximity to, a prosthetic device * known bacteremia or osteomyelitis at time of screening
immunogenicity of 7-valent pneumococcal conjugate vaccine in lung fluid of adults with and without hiv infection

Conditions: Pneumonia; Meningitis; Invasive Pneumococcal Disease; HIV

Summary: lung immune responses are regulated independently of systemic responses. injected vaccines may induce optimal responses in blood but not at mucosal surfaces. we compared the responses in serum and lung fluid to injected pneumococcal conjugate vaccine.

we tested the hypothesis that conjugate vaccine offered less protection against pneumonia due to a reduced mucosal response compared to serum. we further hypothesized that this response would be further compromised with hiv co-infection\[32\] due to lack of local cd4 lymphocyte support and an altered alveolar milieu. we measured pneumococcal capsular specific immunoglobulin responses to 7-valent conjugate vaccine in both lung fluid and serum from healthy hiv infected and uninfected volunteers, together with flow cytometric assessment of the relative numbers and phenotypes of bal t lymphocyte, b lymphocyte and macrophages.

Eligibility criteria:
inclusion criteria: * healthy volunteer adults exclusion criteria: * pregnant, recent illness, previous vaccination, asthma

Keywords: vaccine lung bronchoalveolar lavage lymphocyte immunoglobulin hiv streptococcus pneumoniae conjugate vaccine
a study comparing dulaglutide with insulin glargine on glycemic control in participants with type 2 diabetes (t2d) and moderate or severe chronic kidney disease (ckd)

Conditions: Type 2 Diabetes; Chronic Kidney Disease

Summary: the purpose of this study is to determine the glycemic efficacy and safety of dulaglutide compared to insulin glargine in the treatment of participants with type 2 diabetes and moderate or severe chronic kidney disease.


Eligibility criteria:
inclusion criteria: * men and non-pregnant women aged ≥18 years * hemoglobin a1c (hba1c) ≥7.5% and ≤10.5% * type 2 diabetes on insulin or insulin + oral antihyperglycemic medication * participants with presumed diabetic kidney disease with or without hypertensive nephrosclerosis diagnosed with moderate or severe ckd with estimated glomerular filtration rate (egfr) of ≥15 to \<60 milliliters per minute (ml/min)/1.73 meter squared (m\^2) * able and willing to perform multiple daily injections * body mass index (bmi) between 23 and 45 kilogram/square meter (kg/m\^2) exclusion criteria: * stage 5 ckd as defined by egfr \<15 ml/min/1.73 m\^2 or having required dialysis * rapidly progressing renal dysfunction likely to require renal replacement * history of a transplanted organ * type 1 diabetes mellitus * at screening a systolic blood pressure of ≥150 mmhg or a diastolic blood pressure of ≥90 mmhg with or without antihypertensive medication * an episode of ketoacidosis or hyperosmolar state/coma in the past 6 months or a history of severe hypoglycemia in the past 3 months prior to the screening visit * cardiovascular conditions within 12 weeks prior to randomization: acute myocardial infarction, new york heart association (nyha) class iii or class iv heart failure, or cerebrovascular accident (stroke) * acute or chronic hepatitis * signs and symptoms of chronic or acute pancreatitis, or were in the past diagnosed with pancreatitis * serum calcitonin ≥35 picograms per milliliter (pg/ml) at screening visit * self or family history of medullary c-cell hyperplasia, focal hyperplasia, or carcinoma * known history of untreated proliferative retinopathy