Kornimate/medical-research-clean huggingface dataset:
eus-guided pse in combination with eus-guided treatment of varices for patients with portal hypertension

Conditions: Gastroesophageal Varices; Hypersplenism; Portal Hypertension

Summary: this study aims to evaluate the efficiency of eus-guided combination therapy (eus-guided pse + eus-guided treatment of varices) to eus-guided treatment of varices alone in cirrhotic patients with portal hypertension who have developed gastroesophageal variceal hemorrhage and accompanied with hypersplenism.

partial splenic embolization (pse) was developed in the purpose of managing two common complications of portal hypertension including variceal bleeding and hypersplenism. the procedure is normally performed by clinicians engaged in interventional radiology via a transcatheter embolization method as the successful embolization of the selected splenic arteries results in devascularization of a focal lesion followed by splenic infarction and subsequently reducing the splenic contribution to the portal blood flow. our previous case study suggests implanting coil in a branch of splenic artery under the endoscopic ultrasound (eus) -guidance followed by the glue injection was an alternative pse procedure to control hypersplenism. recent advance has also heightened the therapeutic aspect of eus in managing varices. we have established the novel approach to manage varices and hypersplenism at the same time by combining eus-guided pse and eus-guided treatment of varices. this study aims to evaluate the efficiency of eus-guided combination therapy (eus-guided pse + eus-guided treatment of varices) to eus-guided treatment of varices alone in cirrhotic patients with portal hypertension who have developed gastroesophageal variceal hemorrhage and accompanied with hypersplenism.

Eligibility criteria:
inclusion criteria: * at the risk of gastroesophageal variceal hemorrhage; acute gastroesophageal variceal hemorrhage; hematemesis and/or melena resulted from gastroesophageal variceal hemorrhage of liver cirrhosis in the past. * hypersplenism is indicated by either abdominal ultrasound or ct image showing splenic enlargement or splenomegaly and cbc test showing deficiency of one or more blood cell lines. * consent form must be signed by patients or their guardians before entering the test. exclusion criteria: * history of liver surgery or spleen surgery and liver cancer * coagulopathy (inr \> 1.5) or having been taken oral anticoagulation agents such as aspirin, warfarin, etc. in the past week. * existence of gastrointestinal endoscopic therapy contraindication; hemorrhagic shock has not be corrected; hepatic encephalopathy; moderate to severe ascites, poor liver function (child - pugh class c). * severe cardiorespiratory dysfunction, including sinus bradycardia, bronchial asthma, chronic obstructive pulmonary disease, heart failure, and atrioventricular block * pregnant women and nursing mothers. * absence of informed consent
nonviolent communication for parents

Conditions: Anxiety; Depression Symptom; Well-being

Summary: this randomised controlled trial (rct) aims to evaluate the effectiveness of face-to-face nonviolent communication (nvc) intervention in improving parents' mental well-being and nvc skills, reducing parenting stress, depression and anxiety symptoms, and child emotional and behavioural problems. a total of 172 parents with primary-school-age children will be recruited and randomly assigned to an intervention group or a waitlist control group. the intervention group will receive six weekly 1.5-hour face-to-face nvc training sessions delivered by trained social workers. five to ten social workers will be trained by professional nvc trainers through a train-the-trainer workshop, including three sessions. each social worker will be assessed before (ttt1), after (ttt2) the workshops and 10 months (ttt3). assessments for participants will be conducted at baseline (t1), immediately post-intervention (t2), and at three-month follow-up (t3). after completing the assessments, the waitlist control group will receive the same sessions. qualitative interviews will be conducted to explore participants' experiences and perceptions of nvc.


Eligibility criteria:
inclusion criteria: * 1) parents aged 24-59 years with children of primary school age; * 2) with mild to severe depressive symptoms (score \>5 on the patient health questionnaire (phq)-9) (kroenke et al., 2001) and/or mild to severe anxiety symptoms (score \>5 on the general anxiety disorder (gad)-7) (spitzer et al., 2006); and * 3) hong kong residents who can understand cantonese. exclusion criteria: * 1) under psychiatric treatment, psychotherapy groups and are classified as unstable cases based on the judgment of the recruiting social workers; * 2) participating in other related parenting programmes.

Keywords: nonviolent communication parents depressive symptoms anxiety
effects of the oral care with vaccines for pneumonia in elderly; going home together both physician and dentist

Conditions: Pneumonia

Summary: prospective study comparing the effects of interventions (combined oral care and pneumococcal plus influenza vaccinations) in preventing pneumonia and increasing the survival rate from pneumonia.

the elderly population can be expected to increase not only in developed countries, but also in developing countries. pneumonia is one of the most common causes of death in the elderly. the investigators conducted a prospective study comparing the effects of interventions (combined oral care and pneumococcal plus influenza vaccinations) in preventing pneumonia and increasing the survival rate from pneumonia in consecutive elderly patients at a nursing home in yubari during one year from 2009, with the results in a non-intervention group.

Eligibility criteria:
inclusion criteria: * the residents or an agent who understand the purpose of this study and give informed consent. exclusion criteria: * the residents contraindicated to vaccine

Keywords: oral care vaccine pneumonia elderly prevention primary care
visceral sensitivity in ibd (irritable bowel disease) and ibs (irritable bowel syndrome)

Conditions: IBS; Ulcerative Colitis, Active; Ulcerative Colitis, Remission (3a: With IBS Symptoms, 3b: Without IBS Symptoms); Healthy Controls; Crohn's Disease, Active; Crohn's Disease, Remission (6a: With IBS Symptoms, 6b: Without IBS Symptoms)

Summary: aim: more insight in pathogenesis of ibs and ibd. samples are collected in context of an european research project.

methods: sample collection in healthy subjects, ibd and ibs patients: * biopsy of rectum and colon descendens * blood sample collection * collection of sample of nasal mucosa * feces collection * questionnaires * rectal barostat sensitivity measurement * transit measurement of colon * mr scan of brain

Eligibility criteria:
inclusion criteria: for group 1: ibs 1. irritable bowel syndrome (ibs) (rome iii criteria) 2. no obvious organic explanation for the ibs symptoms 3. medication which affects the gastrointestinal motility or perception should be stopped at least 24 hours before the study group 2: active ulcerative colitis 1. diagnosis of ulcerative colitis (confirmed by at least one sigmoidoscopy) 3. medication which affects the gastrointestinal motility or perception should be stopped at least 24 hours before the study group 3: ulcerative colitis in remission (3a: with ibs symptoms, 3b: without ibs symptoms) 1. diagnosis of ulcerative colitis (confirmed by at least one sigmoidoscopy) 2. remission is confirmed by at least one sigmoidoscopy 3. medication which affects the gastrointestinal motility or perception should be stopped at least 24 hours before the study only for group 3a: 4. rome iii criteria for ibs group 4: healthy controls no abdominal (pain) complaints. group 5: active crohn's disease 1. diagnosis of crohn's disease (confirmed by at least one sigmoidoscopy) 3. medication which affects the gastrointestinal motility or perception should be stopped at least 24 hours before the study group 6: crohn's disease in remission (6a: with ibs symptoms, 6b: without ibs symptoms) 1. diagnosis of crohn's disease (confirmed by at least one sigmoidoscopy) 2. remission is confirmed by at least one sigmoidoscopy 3. medication which affects the gastrointestinal motility or perception should be stopped at least 24 hours before the study exclusion criteria: for all groups: 1. co-morbidity: severe kidney- and/or liver disease or thyroid abnormalities and impaired clotting 2. abdominal chirurgy (except for an uncomplicated appendectomy)
safety and efficacy study of neovasculgen (pl-vegf165) gene therapy in patients with diabetic foot

Conditions: Ulcers Related to Diabetic Foot Syndrome

Summary: the purpose of this study is to determine whether pl-vegf165 (neovasculgen) is effective in the treatment of ulcers related to diabetic foot syndrome

this is a open clinical trial assessing the therapeutic efficacy of pl-vegf165 (neovasculgen) in treating ulcers related to diabetic foot syndrome. each patient will undergo several intramuscular injections with a treatment dose of pl-vegf165 (neovasculgen) in calf of affected extrimity. study participants at the first study visit will complete study questionnaires, their foots will be assessed clinically for ulceration. after this initial assessment, the patients will undergo intramuscular injections of pl-vegf165 (neovasculgen) in a calf altered with ulcers due to diabetic foot syndrome. at three month post-injection, the patient will complete study questionnaires, their foots will be assessed clinically for ulceration, and their foots will undergo non-invasive transcutaneous oximetry measurement. at six months post-injection, the patient will again complete study questionnaires, their foots will be assessed clinically for ulceration and will undergo non-invasive transcutaneous oximetry measurement.

Eligibility criteria:
inclusion criteria: * obtained voluntary informed consent for participation in the clinical study * presence of diabetic foot syndrome * presence at least one active ulcer at baseline exclusion criteria: * any disease that can, in the opinion of the treating physician, affect the outcome of the study * patients with addictive disorders or substance abuse * pregnancy or nursing * all other exclusion criteria listed in the summary of product characteristics (smpc)

Keywords: diabetic foot syndrome ulcers
evaluating factors that impact loss to follow-up among postpartum hiv-infected women in mississippi

Conditions: HIV

Summary: women with hiv infection in mississippi who are pregnant or who have had their baby in the past year can agree to fill out a questionnaire about what helps or hurts return to care for hiv infection after having a baby. the combined results should show the most common things that keep women from getting care for hiv infection after having a baby. this will help design another study in order to help more women get into care for hiv infection after having a baby.

following recruitment and completion of informed consent, a participant will be given a questionnaire to look at factors that help or hinder access to hiv care after delivery. after finishing the initial questionnaire the participant will get a wal-mart gift card for $15. the participant may then be asked to complete a longer interview for which she would receive an additional gift card for $25. the combined results will be used to design an interventional study to improve entry into hiv care after delivery.

Eligibility criteria:
inclusion criteria: * age 18 years or older * women with hiv infection who are pregnant or up to 2 months postpartum * english speaking * able to give informed consent

Keywords: hiv postpartum postpartum entry into hiv care
acupuncture therapy vs chiropractor group therapy to reduce anxiety and depression.

Conditions: Anxiety Depression; HIV/AIDS

Summary: this study aims to determine and compare acupuncture therapy and chiropractor group therapy to reduce anxiety and depression among hiv/aids patients at being alive, los angeles. in this controlled clinical trial, a total of 30 patients will be divided into two groups, 15 in the acupuncture therapy group, 15 in the chiropractor group therapy. the hospital anxiety and depression scale (hads), the patient health questionnaire 9-item (phq-9) and generalized anxiety disorder 7- item scales (gad-7) will be used as screening tools for depressive and anxiety symptoms respectively.

in this study, the objectives are to determine and compare the prevalence of symptoms of depression and anxiety and find the most effective treatment method to assist patients in improving their quality of life utilizing holistic health treatments such as acupuncture and chiropractic to support their physical and mental health. depression and anxiety are currently a major public health challenge worldwide especially during the covid-19 pandemic. approximately 280 million people within the world have depression, and over 700,000 people die due to suicide per annum (who, 2021). this depression and anxiety in plwhas can result in poor quality of life, and quality of work, school, and family life. also, risky sexual behavior, the spreading of the virus, and at its worst, depression can result in suicide. this controlled clinical trial will explore the treatment of acupuncture versus chiropractor care to seek out which treatment can help people living with hiv/aids (plwh/a) to reduce depression and anxiety among plwh/a patients in being alive, los angeles.

Eligibility criteria:
inclusion criteria: * single intervention only exclusion criteria: * chiropractic and acupuncture together

Keywords: anxiety and depression people living with hiv/aids (plwh/a) acupuncture chiropractor
hyperinflammation and hyperferritinemia in critically ill patients

Conditions: Critical Illness; Sepsis; Hyperferritinemia; Hyperinflammatory Syndrome

Summary: analysing trajectory of critically ill patients with signs of hyperinflammation


Eligibility criteria:
inclusion criteria: * critically ill patients * admission between 01.01.2020 and 31.12.2024 (5yrs) exclusion criteria: * none

Keywords: criticall illness sepsis ferritin hyperinflammatory syndrome sepsis phenotype
an analysis of the quality of life and sexual quality of life of cervical cancer radiotherapy patients

Conditions: Cervical Cancer; Radiotherapy Side Effect; Quality of Life

Summary: cervical cancer radiotherapy patients have a decline in quality of life and sexual quality of life

objective: to investigate the quality of life and sexual quality of life and its influencing factors in cervical cancer undergoing radiotherapy patients. methods:the cervical cancer cancer scale (fact-cx4.0) and the female sexual function index (fsfi) in the cancer treatment function evaluation system were used. the quality of life and sexual quality of life of cervical cancer patients undergoing radiotherapy in pumc hospital were analyzed and scored to analyze the effects of age, education level, clinical stage and treatment methods on the quality of life and sexual quality of life of cervical cancer radiotherapy patients

Eligibility criteria:
inclusion criteria: * adult female * diagnosed with cervical cancer' and acquire therapy as part of treatment * undertaken or have finished radiotherapy in peking union medical college hospital * agreed with informed consent exclusion criteria: * with cognitive dysfunction or cannot fulfilled the questionaire * refuse or quit the research * submit questionnaire with missing information
does assessment of ambulance medical service leads to reduced number of transports to the emergency room?

Conditions: Emergency Medical Service; Assessment; Registered Nurse

Summary: there is a need to reduce the number of ambulance transports to the emergency room to the patients who are not in need of urgent medical care. there are currently no studies and the aim of the study is to investigate if the ambulance transports to the emergency room can be reduced by a dialogue between a registered nurse in ambulance and a medical doctor in the primary care (called "ambulant assessment"). in this connection there is also a need to follow up patients that not have been transported to the emergency room, secondary ambulance transport, relapse within 48 hours, type of examination and treatment and mortality.


Eligibility criteria:
inclusion criteria: * patients \>18 years * ambulance missions in the community of borlänge/falun (case) and community of leksand (control) * weekday and weekend, 08:00 to 22:00 * initially evaluated not to need urgent medical care according retts exclusion criteria: * initially evaluated need urgent medical care according retts * the patient unable to give consent to the study * patient with existing care plan * ambulance mission without patient
cluster headache, addictions and vascular function

Conditions: Cluster Headache

Summary: cluster headache (ch) is one of the most painful primitive headaches. developments in neuroimaging have demonstrated activation of the ipsilateral hypothalamic and orexinergic system, which is similar in patients with addictions. ch has strong links to the vascular system but there is no study measuring endothelial function in ch sufferers.

several studies have shown an association between cluster headache (ch) and smoking. however, no data exists on the link between ch and other addictions, and impact of these addictions on clinical characteristics of the disease. in addition, despite the strong biological link between ch and the vascular system, systematic investigations about vascular functions in ch patients are lacking. this will be a prospective cohort study of 150 patients with ch, conducted in the headache center in bordeaux, france.

Eligibility criteria:
inclusion criteria: * presenting a chronic or episodic cluster headache diagnosed according to the international classification of headache disorders (ich-d iii) criteria, in active or inactive phase. exclusion criteria: * other primary headaches * subjects without social insurance
merging of endoscopic and ultrasound images for laparoscopic surgery

Conditions: Prostate Cancer

Summary: visualize surgical needles inserted in the prostate, under the ultrasound modality.

in order to help the surgeon to remove the prostate during a laparoscopic intervention, our goal is to provide an innovative medical device that merges intra-operative ultrasound and endoscopic images. we have already achieved the proof of concept of a device that merges ultrasound and endoscopic images. the objectives of this clinical trial are to accompany the maturation of the fusion device and to make the initial assessments of its medical service. the main difficulty is to visualize markers (surgical needles) under both modalities , in order to merge them.

Eligibility criteria:
inclusion criteria: * of-age patient * patient for whom a radical prostatectomy is planned * patient with a prostate volume between 30g and 100g * patient affiliated to the social security or equivalent * written informed consent exclusion criteria: * contraindication * patient who has undergone a significant prostate resection * patient who has undergone a prostate irradiation * patient concerned by the l1121-6 à 8 of the health public code

Keywords: cancer prostate
stopping versus continuing antiplatelet therapy during noncardiac surgery and procedures after next generation drug-eluting stent implantation

Conditions: Coronary Artery Disease

Summary: most previous trials support the absolute increase in bleeding risk with perioperative administration of antiplatelet. furthermore, recent studies demonstrated that perioperative major bleeding may be related to increase cardiovascular risk. the investigators will compare the efficacy and safety of continuing versus stopping antiplatelet therapy during perioperative period in patients underwent pci(percutaneous coronary intervention) with next generation des(drug eluting stent).

most current guidelines recommend to focus on continuing antiplatelet therapy (mostly with aspirin) during noncardiac surgery if possible. although previous study showed efficacy of continuous antiplatelet therapy in reducing perioperative ischemic cardiovascular events, its effectiveness is still not clear between perioperative bleeding and ischemic risk. most previous trials support the absolute increase in bleeding risk with perioperative administration of antiplatelet. furthermore, recent studies demonstrated that perioperative major bleeding may be related to increase cardiovascular risk. the investigators will compare the efficacy and safety of continuing versus stopping antiplatelet therapy during perioperative period in patients underwent pci(percutaneous coronary intervention) with next generation des(drug eluting stent).

Eligibility criteria:
inclusion criteria: * age 19-85 years * planning of elective noncardiac surgery or invasive procedure * at least 1 year interval between the surgery or procedure and last pci with next generation des * currently on antiplatelet therapy exclusion criteria: * pci with bms(bare metal stent), 1st generation des or bioresorbable vascular scaffold * total length of inserted des in the 3 vessels \>60 mm * history of stent thrombosis * history of coronary artery bypass grafting surgery * planned surgery or procedure with high bleeding risk including followings: intracranial neurosurgery, spinal canal surgery, and eye posterior chamber surgery, endoscopic mucosal resection (emr), endoscopic submucosal dissection (esd), ampullary resection, endoscopic retrograde cholangiopancreatography (ercp) with endoscopic sphincterotomy plus large-balloon papillary dilation, endoscopic ultrasonography-guided fine-needle aspiration (eus-fna) of cystic lesions * left ventricular ejection fraction \<40% * myocardial infarction within 6 months * any overt thromboembolism requiring medical surveillance and/or treatment * any clinically overt sign of hemorrhage within 3 months * anticoagulant therapy for any reason * need of continuation or discontinuation of antiplatelet therapy during surgery or procedure at the discretion of cardiologist or operator * any contraindication, adverse drug reaction or hypersensitivity to aspirin * pregnant women or women with potential childbearing * inability to understand or read the informed content