Kornimate/medical-research-clean huggingface dataset:
repairing the defect of intervertebral disc with autologous bmsc and gelatin sponge after microendoscopic discectomy for lumbar disc herniation

Conditions: Lumbar Disc Herniation

Summary: in this prospective study the investigators seek to evaluate clinical outcomes after repairing the defect of intervertebral disc with autologous bmsc/gelatin sponge during microendoscopic discectomy for participants of lumbar disc herniation.

the participants with lumbar disc herniation diseases are treated by microendoscopic discectomy, and they are divided into four groups depend on whether the defect is repaired with autologous bone marrow stem cell (bmsc)/gelatin sponge or not and whether the defect is sutured or not. in the first group,the defect of intervertebral disc is repaired with autologous bone marrow stem cell (bmsc)/gelatin sponge and sutured. in the second group, the defect of intervertebral disc is repaired with autologous bone marrow stem cell (bmsc)/gelatin sponge but not sutured after discectomy. in the third group, the defect of intervertebral disc is sutured but not repaired with autologous bone marrow stem cell (bmsc)/gelatin sponge after discectomy. in the four group, the defect of intervertebral disc is neither sutured nor repaired with autologous bone marrow stem cell (bmsc)/gelatin sponge after discectomy.

Eligibility criteria:
inclusion criteria: 1. participants with signs and symptoms of lumbar disc herniation requiring surgical treatment after conservative management; 2. radiological data on ct/mri obtained within a period prior to enrollment; 3. participants give written informed consent before enrollment. exclusion criteria: 1. if participants had an incomplete medical record; 2. participants had spine tumor, spine infection, previous underwent lumbar surgery, or revision surgery. 3. participants are taking uninterruptible anticoagulation therapy. 4. dementia and/or inability to give informed consent. 5. mri contraindication (e.g. cerebral aneurysm clips, cochlear implants, pacemaker, implanted biostimulators); 6. pregnancy; 7. participation in other clinical trial within the last 30 days.
effects of a contextual decision-making materials on junior nurses in traumatic learning performance

Conditions: Abdominal Injury; Pelvic Injury

Summary: trauma leading to severe bleeding is one of the reasons for the high mortality rate in trauma patients, resulting in multiple and complex injuries from various accidental mechanisms. however, patients with abdominal-pelvic trauma accidents rank among the top three common accidents in the emergency department. there is a potential for both trauma and severe internal bleeding, making the care of such patients even more challenging. currently, trauma nursing education focuses on emergency medical care, and teaching on the care of abdominal-pelvic trauma occupies only a small part of the entire nursing curriculum. in addition to insufficient knowledge teaching in emergency trauma medical care, learning relies heavily on the arrangement of clinical internships, and obtaining practical experience in the care of abdominal-pelvic trauma is often difficult. in the current era of thriving digital learning, allowing learning to be more diverse and unrestricted by time and location, it is essential to integrate appropriate guiding strategies alongside digital technology to make learning more efficient and promote meaningful learning. therefore, this study introduces decision trees into an interactive scenario-based learning environment for the care of severe bleeding due to abdominal-pelvic trauma. the decision tree is coupled with a decision-making strategy, utilizing the relationships between leaf nodes to guide learners in clarifying their misconceptions, ultimately leading them to make appropriate decisions to reach the final nodes and solve problems. to understand the effectiveness of this study, a real experimental research design is adopted to investigate the impact of introducing decision tree-based interactive teaching materials on the care of severe bleeding in abdominal-pelvic trauma situations on the professional knowledge, self-efficacy, clinical reasoning assessment ability, and technology acceptance of surgical nursing students over a two-year period. it is hoped that this interactive teaching material for the care of severe bleeding in abdominal-pelvic trauma scenarios will enhance learners' professional knowledge, self-efficacy, clinical reasoning assessment, and technology acceptanc.


Eligibility criteria:
inclusion criteria: * holding a nursing license, employed, and having job registration in the same institution. * those who are willing to participate in this study, are informed, and have provided consent by signing the informed consent form exclusion criteria: * those who have completed a service period of more than two years * those who refuse to participate in this study. * non-surgical department ward nurses

Keywords: decision guidance care of severe bleeding in abdominal-pelvic trauma scenario-based learning two-year registered nursing clinical reasoning assessment abdominal injury pelvic injury
intrahospital transport in patients with high-flow nasal oxygenation: prospective observational study

Conditions: Critical Illness

Summary: high-flow nasal oxygen therapy is commonly used in intensive care unit (icu). intra-hospital transfer of critical patients is frequent: 1) to perform diagnostic 2) between emergency room or medical wards and icu. during theses transfers, oxygenation should be continued. there is high-flow nasal oxygen therapy for transport using an external battery. this mode of operation in transport mode allows about 30-45 min of autonomy. intra-hospital transport under high-flow nasal oxygen therapy has been previously described on children. the objective of this study is to evaluate the occurrence of complications during intra-hospital transports under high-flow nasal oxygen of critical patients.

high-flow nasal oxygen therapy is commonly used in intensive care unit (icu). intra-hospital transfer of critical patients is frequent: 1) to perform diagnostic 2) between emergency room or medical wards and icu. during theses transfers, oxygenation should be continued. there is high-flow nasal oxygen therapy for transport using an external battery. this mode of operation in transport mode allows about 30-45 min of autonomy. intra-hospital transport under high-flow nasal oxygen therapy has been previously described on children. the objective of this study is to evaluate the occurrence of complications during intra-hospital transports under high-flow nasal oxygen of critical patients.

Eligibility criteria:
inclusion criteria: * patient treated with high-flow nasal oxygen therapy before the intra-hospital transport prior to transport * requiring an intra-hospital transport (e.g., ct scan, or, etc.) or inter-departmental transport supervised by the icu team nb: once the patient is included in the study, any intra-hospital transport under high-flow nasal oxygen therapy will be analyzed until discharge from the intensive care unit and at until d28. exclusion criteria: * under 18 years old * patient being under guardianship, tutorship or curatorship * pregnancy or breastfeeding * lack of social security number * refusal to participate in the study

Keywords: high-flow nasal oxygenation intra-hospital transport critical ill patients intensive care units
using music during lumbar medial branch block procedure

Conditions: Lower Back Pain; Lumbar Spondylosis

Summary: the purpose of this study is to determine if music therapy during interventional lumbar medial branch blocks for chronic lower back pain will lower pain scores and anxiety levels, while increasing patient desire for repeat procedure as well as patient satisfaction.

subjects will be put into 1 of 2 groups, music or the control group (no music). the music group will listen to patient's preferred music on pandora station broadcast using headphones or wireless earbuds with tablet or computer. hearing impaired patients will have an option of non-earbud headphones. . earbuds or headphones will be used regardless of music therapy playing. . the control group will be provided earbuds or alternative headphone as well, however, with no music. the sound environment will be standardized for procedure by closing procedure room door and minimizing extraneous sounds (i.e. from equipment, alarms, etc.,).

Eligibility criteria:
inclusion criteria: * age\> or equal to 18 * history of documented chronic lower back pain exclusion criteria: * patient refusal * deafness (unless corrected with a hearing aid) * initial pain score \< 3 * prior lumbar medial branch blocks/radiofrequency ablation therapy * any woman who is currently pregnant.

Keywords: lumbar medial branch block chronic back pain lower back pain lumbar spondylosis
karma kontrast evaluating contrast enhanced mammography in early detection of breast cancer

Conditions: Breast Cancer

Summary: women taking part in the national mammography screening program, examined at södersjukhuset breast centre at södra station in stockholm and recalled because of suspicion of breast cancer will be invited to participate. a contrast enhanced mammography will be added to the standard of care procedures for investigating a suspicion of breast cancer and blinded from each other 2 radiologists will evaluate either the contrast enhanced mammography or the standard of care examinations. when comparing the potentially extra findings with contrast enhanced mammography will be calculated. potential side effects together with the patient experience will also be evaluated.


Eligibility criteria:
inclusion criteria: * female * age: \>25 - \<85 years * recalled after mx screening based on abnormal mammographic findings or refered for breast cancer related symtoms * the woman has read, understood and signed the informed consent form (icf) exclusion criteria: * previous breast cancer * a breast biopsy performed within 6 weeks preceding the study * recent exposure (during the last week) to iodine contrast media. * pregnancy * current breast feeding * diagnosed with a pheochromocytoma or a paraganglioma * diagnosed with myeloma or other malignant plasma cell disease * diagnosed with myasthenia gravis * a renal failure or kidney disorder with increased risk for developing renal failure (single kidney or kidney transplanted) * diabetes (other than dietary treated) * heart failure or liver failure * intake of potentially nephrotoxic substances (daily intake of nsaid, nephrotoxic antibiotics or nephrotoxic chemotherapy) * iodine contrast allergy * uncontrolled thyrotoxicosis * a history of severe allergy * subjects unable to read, understand and execute written informed consent * any medical aspect that, according to the investigator, could jeopardize the health of the participant

Keywords: contrast enhanced mammography
ht-3951 vs. placebo in stroke rehabilitation

Conditions: Ischemic Stroke

Summary: this is a randomized, double-blind, placebo-controlled parallel group outpatient study that will utilize standard stroke rehabilitation outcome measures, as well as fmri techniques in a subset of subjects, to evaluate the effect of ht-3951 on motor recovery and behavior in medically stable subjects following ischemic stroke.


Eligibility criteria:
main inclusion criteria: * age range between 21 to 85 years, inclusive, at the screening visit * subjects who have experienced an ischemic stroke documented by ct or mri resulting in an upper extremity deficit that, in the opinion of the investigator, warrants the need for rehabilitation therapy * medically stable subjects who are able to be randomized to study medication beginning between ≥ 2 and ≤ 52 weeks post-stroke * subjects who have initiated, are undergoing, have completed or agree to begin physical or occupational rehabilitation for at least 2 weeks prior to study day 1. * mild to moderate unilateral upper extremity motor impairment characterized by fma-eu score of \> 18 * modified rankin scale score of 1 to 4 main exclusion criteria: * history of stroke within 6 months prior to the subject's current episode of ischemic stroke (history of transient ischemic attacks or ischemic stroke (nonhemorrhagic) more than 6 months prior to the current ischemic stroke are acceptable.) * subjects with unresolved upper or lower motor deficits (e.g., range of motion or strength deficits) from any prior stroke * significant hemorrhagic stroke * any history of seizure disorder or a spontaneous seizure that had occurred at any time after the stroke * apraxia that, in the investigator's opinion, would likely reduce the ability of the subject to participate in the study or confound study outcome measures * moderate to severe aphasia and/or severe language deficits * severe sensory loss in affected hand * moderate to severe hemispatial neglect or anosognosia involving the affected arm * absent proprioception at the elbow or shoulder joints * excessive spasticity in the affected elbow, defined as a score of greater than or equal to 3 on the modified ashworth spasticity scale (mas)

Keywords: stroke, rehabilitation ischemic fmri
psychological distress hipec or pelvic exenteration

Conditions: Colo-rectal Cancer

Summary: the purpose of this study is to describe type and extent of psychological distress (adverse effects) in patients undergoing surgery for colorectal cancer with peritoneal metastases and after surgery for colorectal cancer with involvement of the urinary bladder.

after being informed about the study all patients giving written informed consent will be distributed a questionnaire asking questions on depression, anxiety, self-reported cognitive issues, sleep issues, quality of life and 'fear of cancer recurrence'. all these aspects will be investigated using validated questionnaires. once the investigators have the preliminary results (type and extent of psychological distress developed after crs+hipec or pe) the investigators plan to conduct a workshop. in this workshop experts in different areas regarding psychological distress, project leaders, professor from the 'national center of late adverse effects after cancer in pelvic organs' (denmark) and patients will participate. with the input of experts and patients, a treatment strategy will be developed, and also an assessment will be made concerning which patients are likely to benefit from treatment by these experts, and which patients could potentially benefit from counselling by their general practitioner or via self-helping tools at home. the investigators plan to conduct this workshop autumn 2021 and start counselling spring 2022.

Eligibility criteria:
inclusion criteria: * patients who have undergone intended curative crs+hipec for peritoneal metastases originated from colorectal cancer (hipec cohort) according to national danish guidelines * patients who have undergone intended curative total or anterior pelvic exenteration (pe cohort) for advanced or recurrent colorectal cancer according to national danish guidelines exclusion criteria: * patients under 18 years * patients not speaking danish or swedish, respectively, in denmark and sweden * patients unable to give informed consent * patients undergoing crs+hipec or pe for cancers others than crc * terminally ill patients

Keywords: cytoreductive surgery hyperthermic intraperitoneal chemotherapy pelvic exenteration adverse effects psychological distress anxiety depression fear of cancer recurrence cognitive dysfunction quality of life
avazzia-university of texas southwestern medical center-tennant biomodulator® pro perfusion study

Conditions: Perfusion; Complications; Wound; Foot

Summary: this study is an open label trial designed to test the effectiveness of the tennant biomodulator® pro electrical stimulation device (avazzia), which uses best™ (bio-electric stimulation technology), on hospital in-patients to improve perfusion in the treated and contralateral limb.


Eligibility criteria:
inclusion criteria: * able to provide informed consent * ankle brachial index (abi) ≥ 0.5 (bedside abi is acceptable for screening purposes as the formal imaging abi may not be resulted prior to therapy) * participant is a hospital in-patient for the duration of study procedures * one or more chronic lower extremity wounds that are located in the ankle area or below that has persisted a minimum of 30 days prior to the screening visit * 18 years of age or older exclusion criteria: * unable to provide informed consent * \<18 years of age * participant has a demand-type cardiac pacemaker, implanted defibrillator or other implanted metallic or electronic device. * participant has untreated osteomyelitis * participant has active cellulitis * participant has active charcot * is pregnant or plans to become pregnant * is nursing or actively lactating * developmental disability/significant psychological disorder that in the opinion of the investigator could impair the participant's ability to provide informed consent, participate in the study protocol including untreated schizophrenia, bipolar disorder and psychiatric hospitalization within the last 2 years.

Keywords: electrical stimulation perfusion foot wound foot pain
safety and efficacy of apd356 in the treatment of obesity

Conditions: Obesity

Summary: this is a research study of an investigational drug, apd356, a novel, selective 5-ht2c receptor agonist, in clinical development as a potential treatment for obesity. the purpose of this study is to obtain preliminary assessment of the safety and efficacy of apd356, when administered daily for 28 days, in obese subjects who are otherwise healthy.

this is a double-blind, placebo-controlled, randomized, parallel group study. three different doses of apd356 or placebo will be administered daily for 28 days, to uncomplicated obese, male and nonpregnant, nonlactating, female volunteers, aged 18 to 65 years. approximately 400 subjects will be enrolled.

Eligibility criteria:
* healthy male or nonpregnant, nonlactating females aged between 18 and 65 years (inclusive) * body mass index (bmi) of 30-45 kg/m\^2. * non-smoker * no concomitant medications * no past treatment with drugs associated with the development of pulmonary hypertension or cardiac valvular insufficiency

Keywords: serotonin 5-ht2c satiety obesity appetite suppressant weight loss overweight
stellate ganglion block for prevention of post mastectomy depression

Conditions: Mastectomy; Pain, Acute; Pain, Chronic

Summary: complications after mastectomy include chronic pain and depression.

a mastectomy is surgery could be associated with complications include chronic pain and depression. in female breast cancer patients, the incidence of postoperative depression was 46.55%. stellate ganglion block had been used for treating post-traumatic stress disorder (ptsd) and depression symptoms even in its prevention. also, it used in treatment of chronic pain.

Eligibility criteria:
inclusion criteria: * female patients * age ranging from 18 to 65 years * american society of anesthesiologists (asa) no more than ii * had unilateral cancer breast * scheduled to do unilateral modified radical mastectomy exclusion criteria: * pregnant female * existing horner syndrome * had any neuromuscular disease * had allergy to local anesthetics * history of use of analgesics * had any deformity or a previous surgery in the neck or ipsilateral arm or breast * had any contraindication to the procedure (coagulation disorders, local infection, sepsis) * had any contraindication to the sympathetic blockade (decompensate cardiopulmonary or hemodynamic disorders) * history of psychotic disorder including depression, bipolar disorder or personality disorder * patient with beck depression inventory (bdi) score more than 13
safety and efficacy of cariprazine (rgh-188) in the acute exacerbation of schizophrenia

Conditions: Schizophrenia

Summary: this is a study to evaluate the safety, efficacy, and tolerability of cariprazine (rgh-188) relative to placebo in adult patients (18-60 years of age) with acute exacerbation of schizophrenia.


Eligibility criteria:
inclusion criteria: * male or female, 18 to 60 years of age. * meets diagnostic and statistical manual of mental disorders, 4th edition (dsm-iv) criteria for schizophrenia (paranoid type, disorganized type, catatonic type, or undifferentiated type) based on a structured clinical interview for dsm-iv (scid). * total positive and negative syndrome scale (panss) score ≥ 80 and ≤ 120. * diagnosis of schizophrenia for at least 1 year. exclusion criteria: * abnormalities on physical examination or abnormal vital signs, electrocardiogram, or clinical laboratory values. * first episode of psychosis.
remote ischemic conditioning to enhance resuscitation (rice) pilot

Conditions: Cardiac Arrest

Summary: following resuscitation from out-of-hospital cardiac arrest (ohca), reperfusion injury can cause cell damage in the heart and brain. remote ischemic conditioning (ric) consists of intermittent application of a device such as a blood pressure cuff to a limb to induce non-lethal ischemia. studies in animals with cardiac arrest as well as in humans with acute myocardial infarction suggest that ric before or after restoration of blood flow may reduce injury to the heart and improve outcomes but this has not been proven in humans who have had ohca. the rice pilot study is a single-center study to assess the feasibility of application of ric in the emergency department setting for patients transported to the hospital after resuscitation from ohca.


Eligibility criteria:
included will be those with: 1. age 18 years or more; 2. defibrillation by laypersons or defibrillation and/or chest compressions by ems providers dispatched to the scene; 3. non-traumatic etiology of arrest, defined as without concomitant blunt, penetrating, or burn-related injury, or uncontrolled bleeding or exsanguination; 4. spontaneous circulation upon emergency department arrival; 5. no response to verbal commands; and 6. ongoing or planned induced hypothermia. excluded will be those with: 1. stemi indicated on first 12-lead ecg obtained after restoration of circulation, defined as st-elevation of ≥2 mm in two or more contiguous ecg leads; 2. written do not attempt resuscitation (dnar) reported to providers before randomization; 3. drowning or hypothermia as cause of arrest; 4. known prisoner or pregnant; or 5. dialysis fistula in either upper extremity; or 6. pre-existing amputation of upper extremity.

Keywords: reperfusion injury remote ischemic conditioning