Kornimate/medical-research-clean huggingface dataset:
comparison of the effects of advanced exercise treatment performed under the supervision of a physiotherapist and provided as a home program on adduction angle, pain, functional status, quality of life and kinesophobia in individuals with hallux valgus

Conditions: Exercise; Hallux Valgus

Summary: the aim of our study is to compare the effects of progressive exercise therapy, administered as a home program under the supervision of a physiotherapist, on adduction angle, pain, functional status, quality of life, and kinesiophobia in individuals aged 18-64 years with a hallux valgus angle of 15-40 degrees (mild-moderate).

according to the power analysis, 18 people will participate in the study. individuals with halluk valgus pain, deformity angle, balance, functional capacity, functionality, quality of life and kinesiophobia will be evaluated.after the individuals are evaluated, they will be randomly divided into 2 groups as the exercise group and the home exercise group. all patients will be instructed on wearing appropriate footwear (made of soft material, with a wide round toe, with a normal heel height between 1 inch and 1.5 inches (2.5-3.8 cm). in addition, in order to increase the awareness of the participants, they will be asked to focus on how muscle activation feels during exercise and they will be asked to perform this activation during daily living activities. the exercise program to be given to both groups will be the same, and will be applied with bare feet 4 days a week for 8 weeks. the exercise program will be advanced as recommended in the literature and 30 seconds of rest will be given between sets. after the evaluation, all exercises will be shown to the home exercise group and it will be ensured that they are applied correctly. an illustrated and narrative exercise program brochure containing information about exercise position, number of repetitions, contraction time, rest time between sets, frequency and exercise diary will be given to the patient for exercise follow-up. at the end of 8 weeks, the evaluations will be repeated by the same physiotherapist.

Eligibility criteria:
inclusion criteria: * volunteer individuals between the ages of 18-64 * mild to moderate (15-40 degrees) hallux valgus * bilateral hallux valgus * have not received physical therapy for hallux valgus in the last 6 months, * individuals who did not use orthotic devices or dynamic splints for the treatment of hallux valgus will be included in the study. exclusion criteria: * hva ≥ 45° * rjjit hallux valgus deformity (in cases where the hallux cannot be brought to its normal position manually) * obesity (bmi\>30 kg/m2) * systemic disease and inflammatory arthritis (rheumatoid arthritis, systemic lupus, diabetes mellitus) * neurological disease (eg: neuropathy) * vestibular disorder that may affect balance * history of standing trauma, fracture of the metatarophalangeal joint, * he has undergone foot-ankle surgery, * using nsaids or analgesics

Keywords: hallux valgus exercise home program
communication bridge 3 study

Conditions: Primary Progressive Aphasia

Summary: this study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild-moderate primary progressive aphasia (ppa). the aim of the study is to help us better understand the effects of speech-language therapy on communication abilities in individuals with ppa.

participants with a diagnosis of ppa and their actively-engaged care partners will be involved in the study for approximately 17 months. each participant will receive a laptop equipped with the necessary applications and features for the study. participants will receive up to 10 evaluations and 20 speech therapy sessions with a licensed speech therapist, as well as access to communication bridge, a personalized web application to practice home exercises that reinforce treatment strategies. there are no costs to participate in this study.

Eligibility criteria:
inclusion criteria (person with ppa): 1. meets diagnostic criteria for ppa based on neurologist and supporting medical assessments (extracted from medical records) 2. english as primary language used in daily communication activities (by self-report) 3. adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report) 4. adequate vision (aided or unaided) for reading a newspaper, or other functional materials (by self-report) 5. able to pass technology screening and demonstrates sufficient knowledge for use of video conference and communication bridge™ web application use (with or without training) 6. geriatric depression scale score ≤ 9 7. mild-moderate ppa informed by a structured interview with a speech-language pathologist and a standardized testing battery. inclusion criteria (co-enrolled communication partner): 1. 18+ years of age 2. english as primary language used in daily communication activities (by self-report) 3. adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report) 4. able to pass technology screening\* and demonstrates sufficient knowledge for use of video conference and communication bridge™ web application use (with or without training) exclusion criteria: * a dementia diagnosis other than primary progressive aphasia * participation is co-enrolled in an outside speech language therapy program during the study course. * communication partners will be excluded if they have a pre-existing communication impairment that would affect study participation (e.g., aphasia, dementia) medical records will be requested and reviewed to determine eligibility

Keywords: aphasia dementia communication frontotemporal dementia alzheimer disease
absorbable sutures , non absorbable sutures or biologic fibrin glue for protesic mesh fixing in lichtenstein technique for primitive groin hernia repair: a randomized prospective multicentric trial

Conditions: Hernia, Inguinal

Summary: this study has the aim to analize the correlation between three different methods of mesh fixation ( using absorbable or non absorbable sutures or fibrin biological glue) and recurrance and chronic pain ,in the lichtenstein anterior inguinal erniorrhaphy

in the last decades the rate of recurrence in the anterior inguinal erniorraphy has been drastically lowered with the introduction of the mesh , on the other hand the rate of chronic pain is reported to be high in many papers. the chronic pain influences the quality of life and what's more causes an increase in the social costs. the classical lichtenstein inguinal anterior erniorrhaphy , wich is the technique suggested by the international guidelines, expected to fix the mesh with non absorbable sutures . the investigators would analyze the possible correlation between the method of mesh fixation and chronic pain keeping a lower rate of recurrence. that said the primary endpoint in this study is the rate of recurrence and the secondary endpoint is the rate of chronic pain after lichtenstein anterior inguinal erniorrhaphy in the three different methods of fixation of the mesh

Eligibility criteria:
inclusion criteria: * primitive inguinal hernia * age \> 18 years old * compliancy to the study exclusion criteria: * reccurent inguinal hernia * age \< 18 years old * refusal of the study

Keywords: groin hernia lichtenstein herniorrhaphy
a study to evaluate oral salmon calcitonin in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin d

Conditions: Osteoporosis

Summary: the purpose of this phase iii study is to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of patients with osteoporosis


Eligibility criteria:
inclusion criteria: * postmenopausal women with osteoporosis, ambulatory, in general good health, not receiving medication that affects bone metabolism, and free from any underlying condition, other than osteoporosis, that may result in abnormal bone metabolism. exclusion criteria: * bmd t-score below -4.0 (based on absolute values g/cm2 as given in the protocol) at one or more of the measured sites * more than 2 prevalent vertebral fractures (genant et al, 15). * if bmd is lower than -2.5 t-score at one or more of the measured sites, the participants will be excluded from the study, if they have a severe vertebral fracture (genant et al, 15). * evidence of any clinical osteoporotic fracture and/or if they have a history of a clinical osteoporotic fracture (excluding wrist fractures) * bmd t-score \> -1.5 in all of the following regions: lumbar spine, femoral neck or total hip. other protocol defined inclusion/exclusion criteria may apply

Keywords: osteoporosis, oral salmon calcitonin, treatment, efficacy, tolerability
decision-making and the relationship to food intake in kids

Conditions: Pediatric Obesity

Summary: the purpose of this 18-month project is to investigate how decision-making influences food choice and consumption in children ages 7 to 11 years old. although several studies suggest that the ability to make good decisions relates to eating behaviors, no studies have looked at how food reward influences the decision-making process to impact actual food intake. this proposal will answer these questions and bridge this gap in knowledge, which could lead to the development of more effective interventions for childhood obesity. to accomplish this, the investigators have assembled a diverse team with expertise in food intake, nutrition, and decision sciences. first, the investigators will establish if there are differences in decision-making between children varying in weight status. second, the investigators will determine if performance on behavioral decision-making tasks relates to food consumption in the laboratory. third, the investigators will examine response functional magnetic resonance imaging (fmri) blood-oxygen-level-dependent (bold) response to various rewards (i.e. food and money) and determine if this is influenced by child weight status. fourth, the investigators will examine differences in fmri bold at rest in decision-making regions are correlated with food intake and weight status. eighty-two children will participate in our study. the long-term goal of this project is to investigate if there are differences in brain regions corresponding to these behaviors in overweight children and if these differences relate to eating behaviors in this population. children will undergo fmri while playing a reward task as well as consume meals in our laboratory. decision-making will also be assessed by having children complete various behavioral measurements of reward and inhibitory control.


Eligibility criteria:
inclusion criteria: * right-handed * english as native language * reading at/above grade level * not claustrophobic * generally healthy exclusion criteria: * left-handedness * metal in or on body that cannot be removed * claustrophobia * medication usage that may alter brain activity or blood flow * medical disorder that may impact comfort of safety in mri scanner * food allergies * dietary restrictions * learning disabilities * psychiatric disorders
improving health and reducing disability of depressed elderly with chronic conditions through qigong exercise

Conditions: Chronic Disease; Depressive Symptoms

Summary: qigong exercise is beneficial for older adults with co-occurring chronic physical illness and depression in terms of psychological and physical outcomes. however, the effects on functional independence, sleep quality, and mobility of depressive older adults remain unclear. it is also important to replicate its benefits for subjective well-being and muscle strength. a randomized clinical trial was conducted among older adults who were aged 60 or above and with chronic medical conditions for one year. after random assignment, intervention group (n = 25) went through qigong exercise twice a week and for 12 weeks,whereas control group (n = 22) was involved in cognitive training activities with mobilization elements. the psychosocial and physical outcomes of the two groups were compared.


Eligibility criteria:
inclusion criteria: * aged 60 or above * have been suffering from chronic medical conditions for more than one year * have depressive symptoms as indicated by geriatric depression scale (gds ≥ 6) exclusion criteria: * have practiced or received training of any form of mind-body exercises (including tai chi, yoga, and qigong) during the 6 months prior to intervention. * have changed medication or the dosage prior to or during intervention * have obvious cognitive and language impairment or score less than 20 in mini-mental state examination (mmse) * undergo electroconvulsive therapy, psychotherapy, or psychoeducation * cannot demonstrate satisfactory sitting balance
high-dose dual therapy and minocycline-cotaining quadruple therapy for helicobacter pylori infection

Conditions: Helicobacter Pylori Infection

Summary: this study is a multicentra, prospective study. the enrolled patients are hp positive. they are diagnosed as hp positive by rapid urease test and/or 13c urea breath test. according to the declaration of helsinki, 200 patients will be included in this study. after obtaining the written informed consent of the patients, hp culture and drug sensitivity test will be conducted on all the selected patients with the success rate, adverse reactions, compliance, antibiotic resistance of hp and its impact on hp eradication.


Eligibility criteria:
inclusion criteria: * ability and willingness to participate in the study and to sign and give informed consent * confirmed h. pylori infection exclusion criteria: * pregnant and lactating women; * history of gastrointestinal malignancies; * history of previous subtotal gastrectomy; * serious dysfunction of heart, liver, kidney, lung and other important organs and congenital diseases; such as grade iv cardiac insufficiency, liver failure, uremia, respiratory failure, hemophilia, wilson disease, etc; * history of hematological diseases * people who are allergic to drugs; * the guardian or patient refused to join the group; * alcohol and / or drug abuse (addiction or dependence) or poor compliance judged by doctors; * no legal capacity or poor self-knowledge * administration of antibiotics, bismuth, antisecretory drugs, or chinese herb medicine in the preceding 8 weeks

Keywords: helicobacter pylori minocycline amoxicillin
examination of musculoskeletal system problems, pain and quality of life related to working conditions in chiropractors

Conditions: Musculoskeletal Problems, Pain, and QoL in Chiropractors in Relation to Their Working Conditions

Summary: this research aims to investigate musculoskeletal problems and pain, as well as their effects on the quality of life, arising from the working conditions of chiropractors in their workplaces. additionally, it is intended to conduct a detailed analysis of working conditions in chiropractors' work environments to identify existing problems, establish the cause-and-effect relationship between musculoskeletal problems, pain, and these conditions, conduct studies to improve chiropractors' work environments, and demonstrate the positive effects of improving working conditions on the quality of life and professional performance of chiropractors. within this scope, the physical layout of chiropractors' work environments, ergonomic factors, and workplace conditions will be analyzed. musculoskeletal problems experienced by chiropractors will be identified, and research will be conducted on pain and musculoskeletal disorders associated with workplace factors. furthermore, the effects of working conditions on the quality of life of chiropractors will be evaluated.


Eligibility criteria:
inclusion criteria: * male and female physiotherapists between the ages of 25-45, with at least 1 year of chiropractic experience, will be selected exclusion criteria: * having practiced chiropractic for less than 1 year.

Keywords: musculoskeletal system problems, pain, quality of life, chiropractors
glutamine supplementation and short-term mortality in covid-19

Conditions: Covid19

Summary: the aim of this study is to investigate the effect of parenteral l-glutamine supplementation added to enteral nutrition on short-term icu mortality (7 days) in covid-19 diseased patients.

a written informed consent will be taken from the patients or their relatives. patients with diagnosis of covid-19 with enteral nutrition will be enrolled. patients will be randomly assigned to receive either standard enteral nutrition (group en) or intravenous glutamine supplementation to enteral nutrition (group gn) in a dose of glutamine of 0.4 g/kg/day during icu stay.

Eligibility criteria:
inclusion criteria: * diagnosis of covid-19 diseased patients admitted to the icu with enteral nutrition. exclusion criteria: * renal failure (creatinine \>180 mmol/l) * hepatic failure (bilirubin \>40 mmol/l, alanine aminotransferase \>100 u/l and aspartate aminotransferase \>100 u/l) * severe neutropenia (\<500 cells/mm3) * patients receiving cytotoxic, radiation and/or steroid therapy * hemodynamic instability
characterisation of tim-3/gal-9 immune checkpoints in primary central nervous system diffuse large b cell lymphomas

Conditions: Lymphoma, B-Cell

Summary: primary central nervous system diffuse large b cell lymphoma is a rare and aggressive entity of diffuse large b cell lymphoma. a previous transcriptomic study showed an overexpression of tim-3 and gal-9 in the tumor microenvironment. the investigators aimed to characterise tim-3/gal-9 immune checkpoints by using immunohistochemistry in the tumor microenvironment of primary central nervous system diffuse large b cell lymphoma.


Eligibility criteria:
inclusion criteria: - patient with a diagnosis of lbdgc-snc exclusion criteria: * immunocompromised patients * patients with a history of previous or associated low-grade lymphoma * patients with a history of systemic lbdgc with secondary localization to the snc
phase i study of gsk233705 in healthy japanese male subjects

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this is a randomised, double blind, placebo-controlled, 2-parts study to investigate the safety, tolerability, and pharmacokinetics of single and repeat inhaled doses of gsk233705 from a novel dry powder device in healthy japanese male subjects.


Eligibility criteria:
inclusion criteria: 1. japanese healthy male subjects aged between 20 and 64 years of age inclusive. healthy subjects are defined as individuals who are free from clinically significant illness or disease as determined by their medical history, physical examination, laboratory studies, and other tests. 2. body weight ≥ 50kg and bmi within the range 18.50-25.00kg/m2 inclusive. 3. non-smokers (never smoked or not smoking for \>6 months with \<10 pack years history (pack years = (cigarettes per day smoked/20) x number of years smoked)) 4. normal spirometry (fev1 ≥ 80% of predicted, fev1/fvc ≥ 70%). 5. clinical laboratory tests data obtained at screening meet the following: ast(got), alt(gpt), total-bilirubin: below the upper limit of the normal ranges 6. normal 12-lead egc finding at screening; qtc interval \<450msec 7. a mean blood pressure lower than 140/90mmhg at screening. 8. capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form. 9. capable of using the novel dry powder inhaler. exclusion criteria: 1. the subject has any clinically relevant abnormality on medical examination, vital sign, clinical laboratory test or medical history at screening in the medical opinion of the investigator or the subject has a medical history that is not considered as eligible for inclusion in this study by the investigator. 2. the subject is currently participating in another clinical study or post-marketing study in which the subject is or will be exposed to an investigational or a non-investigational drug or device. 3. the subject has participated in a clinical study with an investigational or a non-investigational drug or device during the previous 4 months. 4. a history of breathing problems (i.e. history of asthmatic symptomatology, asthma in childhood). 5. the subject has a known allergy or hypersensitivity to ipratropium bromide, tiotropium, atropine and any of its derivatives. 6. the subject has a known allergy or hypersensitivity to milk protein or the excipients lactose monohydrate and magnesium stearate. 7. the subject has a history or current conditions of drug abuse or alcoholism. 8. history of regular alcohol consumption exceeding on average, 14 drinks/week (1 drink=5 ounces (150ml) of wine or 350ml of beer or 1.5 ounces (45ml) of 80 proof distilled spirits) within 6 month of screening. 9. the subject is positive for urine drug screening. 10. the subject is positive for syphilis, hbs antigen, hcv antibody, hiv antibody, htlv-1 antibody. 11. the subject has donated a unit of blood "\>400ml" within the previous 4 months or "\>200ml" within the previous 1 month.
perioperative pregabalin and continuous wound infusion for pain control following thoracotomy

Conditions: Post-thoracotomy Pain

Summary: the purpose of this study is to assess the efficacy of pregabalin or pregabalin and continuous wound infusion versus placebo for analgesia following thoracotomy


Eligibility criteria:
inclusion criteria: * patients scheduled for a thoracotomy, exclusion criteria: * age \>70 years * bmi \> 30 * preoperative hb \< 10 mg/dl * preexistent chronic pain * neurologic disease * chronic assumption of alcohol * treatment with analgesics, anxiolytics, sedatives, antidepressants, or calcium channel inhibitors
pharmacodynamic bioequivalence of metered dose inhalers of albuterol sulfate in patients with stable mild asthma

Conditions: Bronchial Asthma

Summary: the purpose of this study is to demonstrate the pharmacodynamic bioequivalence of the test product to the reference product, using bronchoprovocation (methacholine challenge testing) in adult patients with stable mild asthma.

this study is to demonstrate the pharmacodynamic bioequivalence of the test product to the reference product in terms of fev1 measured at different time-points, using bronchoprovocation (methacholine challenge testing) in adult patients with stable mild asthma.

Eligibility criteria:
inclusion criteria: * male and non-pregnant female subjects (18-65 years of age) * forced expiratory volume in 1 second (fev1) ≥ 80% of predicted. airway responsiveness to methacholine demonstrated by a pre-albuterol dose (baseline) pc20 ≤ 8 mg/ml. * stable mild asthmatics based on national asthma education and prevention program (naepp) guidelines. * nonsmokers for at least 6 months prior to the study and a maximum smoking history of five pack-years (the equivalent of one pack per day for five years). * written informed consent. exclusion criteria: * conditions which could alter airway reactivity to methacholine (e.g., pneumonia, upper respiratory tract infection, viral bronchitis and/or sinobronchitis) within six weeks prior to the screening visit. * history of seasonal asthma exacerbations, in which case the patient should be studied outside of the relevant allergen season. * history of a clinically significant disease or abnormality including congestive heart failure, uncontrolled hypertension, uncontrolled coronary artery disease, myocardial infarction, or cardiac dysrhythmia. * history of cystic fibrosis, bronchiectasis or other respiratory diseases other than asthma * historical or current evidence of significant hematologic, hepatic, neurologic, psychiatric, renal, or other diseases * known intolerance or hypersensitivity or hypersensitivity to any component of the albuterol metered dose inhaler (mdi).