Kornimate/medical-research-clean huggingface dataset:
effect of tai chi on functional fitness of elderly patients with degenerative arthritis

Conditions: Exercise Training

Summary: degenerative arthritis is a common disease in the elderly , in recent years, there are young trends, the symptoms often cause great pain in the elderly, associated with lower physical exercise caused by decreased muscle mass, functional fitness performance is also poor, affecting the ability of elderly people to live independently. therefore, this study mainly explores whether the intervention of tai chi can improve the functional fitness of the elderly and reduce the pain index of the elderly. the study was designed to take the sample, which was divided into experimental group and control group. it was expected to receive 100 people. the subjects were asked to use the basic information, karnofsky scale, the functional fitness test, the exercise conscious scale and the womac pain scale were used as the research tools. the spss system was used to analyze whether the functional fitness index and the pain index were significantly different before and after exercise intervention. whether the exercise intervention has an effect on the elderly.

degenerative arthritis is a common disease in the elderly , in recent years, there are young trends, the symptoms often cause great pain in the elderly, associated with lower physical exercise caused by decreased muscle mass, functional fitness performance is also poor, affecting the ability of elderly people to live independently. therefore, this study mainly explores whether the intervention of tai chi can improve the functional fitness of the elderly and reduce the pain index of the elderly. the study was designed to take the sample, which was divided into experimental group and control group. it was expected to receive 100 people. the subjects were asked to use the basic information, karnofsky scale, the functional fitness test, the exercise conscious scale and the womac pain scale were used as the research tools. the spss system was used to analyze whether the functional fitness index and the pain index were significantly different before and after exercise intervention. whether the exercise intervention has an effect on the elderly.

Eligibility criteria:
inclusion criteria: 1. elderly persons aged 65 or above who actively participate in community activities 2. awareness mmse score ≧ 25 and can use the chinese, taiwanese fluent communication 3. can stand for more than 60 minutes and the kirsley scale for the second to zero level. exclusion criteria: 1. medical advice for those who can not exercise 2. suffering from significant cardiovascular and heart disease 3. suffering from high blood pressure, asthma, diabetes 4. those suffering from skeletal muscle disease
behavioral ai to predict and increase peritoneal dialysis uptake

Conditions: Chronic Kidney Disease

Summary: scaled insights behavioral ai will be used to improve clinicians ability to detect and understand: the likelihood of patients with kidney failure opting for peritoneal dialysis and to select the right personalized nudge to get ckd patients to choose peritoneal dialysis scaled insights' can utilize the data from this study to develop individualized nudges for healthcare professionals that can be broadly deployed within a digital platform so that clinics across the english speaking world can use it as a means of supporting patients with ckd in selecting peritoneal dialysis treatment. using scaled insights novel behavioral artificial intelligence solution, the proposed project has two aims: 1. to identify personality attributes of patients with chronic kidney disease and correlating their personality attributes with their subsequent choice of dialysis. once correlated into personality based clusters, the ai model will then be able will determine which personality cluster each net new patient will fall into and therefore predict their specific likelihood of opting for peritoneal dialysis or hemodialysis 2. once prediction is possible, customized nudges towards the selection of pd will be developed and tested to improve the likelihood that patients will opt for peritoneal dialysis hypotheses: 1. scaled insights behavioral ai will identify the personality characteristics of patients with chronic kidney disease who are likely to opt for both peritoneal dialysis and hemodialysis (phase 1) 2. scaled insights behavioral ai will identify the nudges that are most effective in encouraging or supporting patients with chronic kidney disease in choosing peritoneal dialysis over hemodialysis (phase 2)


Eligibility criteria:
inclusion criteria: * phase 1: us and uk adult patients aged 18+ years, with chronic kidney disease stage 4-5. * phase 2: us and uk adult patients aged 18+ years, with chronic kidney disease stage 4-5. exclusion criteria: * phase 1: young people aged \&lt;18 years. people who do not have chronic kidney disease. people who reside outside of the usa and uk. * phases 2: young people aged \&lt;18 years. people who do not have chronic kidney disease stage 4-5. people who reside outside of the usa and uk.

Keywords: chronic kidney disease artificial intelligence dialysis
clinical comparison of two soft contact lenses

Conditions: Myopia

Summary: this study was designed to gather short-term clinical performance data for 2 soft contact lenses.

the purpose of this participant-masked, non-randomized, crossover controlled, non-dispensing, study was to compare the short-term performance of 2 daily disposable contact lenses after 15 minutes of daily wear each. the lenses were identical in all aspects except for diameter. participants attended for 1 visit only which lasted for approximately 2 hours.

Eligibility criteria:
inclusion criteria: * subjects will only be eligible for the study if: 1. they were of legal age (18) and capacity to volunteer. 2. they understood their rights as a research subject and were willing and able to sign a statement of informed consent. 3. they were willing and able to follow the protocol. 4. they were wearing soft contact lenses, or had done so within the past two years. 5. they were able to be fitted with the study lenses within the power range available. exclusion criteria: * subjects will not be eligible if: 1. they had an ocular disorder which would normally contra-indicate contact lens wear. 2. they had a systemic disorder which would normally contra-indicate contact lens wear. 3. they were using any topical medication such as eye drops or ointment. 4. they were aphakic. 5. they had had corneal refractive surgery. 6. they had any corneal distortion resulting from previous hard or rigid lens wear or had keratoconus. 7. they were pregnant or lactating. 8. they had an eye or health condition including an immunosuppressive or infectious disease which could, in the opinion of the investigator, contraindicate contact lens wear or pose a risk to study personnel; or a history of anaphylaxis or severe allergic reaction. 9. they had taken part in any contact lens or care system clinical research within two weeks prior to starting this study.
efficacy and safety study on nasogastric (ng) tube in patients with upper gastrointestinal bleed

Conditions: Gastrointestinal Hemorrhage; Liver Cirrhosis

Summary: upper gastrointestinal tract hemorrhage (ugih) remains a major cause of morbidity and mortality . nasogastric aspiration (nga) is routinely performed in patients with ugih to obtain important clinical data and make therapeutic decisions. but routine use of nga remains controversial with studies reporting its usefulness and its redundant clinical information. early esophagogastroduodenoscopy (egd) is recommended by most gastrointestinal societies to allow for risk stratification and to perform endoscopic treatments. the results of the nga may assist to differentiate between high-risk versus low-risk lesions. our hypothesis is that presence of nga can identify lesions that require endoscopic treatment and provides important clinical information to guide the treating physician. in addition, we hypothesized that the results of the nga influence the clinical decision of the treating physician regarding the prediction of the need for endoscopic therapy. this observational randomized cross-sectional study will enroll consecutive patients with presumed ugih and randomized them to nga and no nga recording its results. all patients will receive an egd and its results will also be recorded. subsequently, we will evaluate if the nga is important in identifying endoscopically significant lesions. the information gained will help guide clinicians evaluating patient with ugih.


Eligibility criteria:
inclusion criteria: * patients older then 21 years-old presenting with actual or reported: hematemesis, melena, or hematemesis and melena exclusion criteria: * refusal to participate * severe comorbid conditions making egd hazardous for the patient, such as myocardial infarction \< 3 months with the exception if the myocardial infarction was caused by the ugih, hemorrhagic or ischemic stroke \< 3 months, decompensated congestive heart failure, severe respiratory failure unless the patient is already intubated * survival expected to be less than 72h as judged by treating clinician * prisoners * patient with severe mental illness precluding the ability to obtain informed consent * ongoing anticoagulation which can not be reversed secondary to patient safety * strongly suspected gastrointestinal perforation * recent endoscopy (less than 30 days)

Keywords: gastrointestinal hemorrhage gastrointestinal intubation endoscopy
pk and pd responses to oral l-citrulline in patients with sickle cell disease

Conditions: Sickle Cell Disease

Summary: to evaluate pk and pd responses to l-citrulline given orally for four weeks to patients with sickle cell disease who are otherwise healthy.

phase 1, single center, open label, multiple-dose study consisting of a screening period followed by four weeks of treatment. at least 12 male and female patients, 10 years of age or older, with sickle cell disease but otherwise healthy, will be enrolled in the study. pk measurements include plasma concentrations of l-citrulline, l-arginine, l-ornithine, and l-proline following the first dose of orally administered l-citrulline and after four weeks of twice daily administration of the drug. pd measurements include intercellular and vascular adhesion molecules (icam, vcam, and e-selectin), surrogate markers of sickle cell disease activity, and pat, a measurement of vascular function.

Eligibility criteria:
inclusion criteria: 1. male or female, 10 years of age or older on the day of dosing, and generally healthy as determined by medical history, physical examination, and laboratory test values 2. diagnosis of sickle cell anemia (hb ss) 3. for female of child-bearing potential, a negative serum pregnancy test and using an adequate method of contraception 4. has signed and received a copy of the written informed consent form approved by the investigator's institutional review board (irb), understands the purposes and risks of the study and agrees to follow the restrictions and schedule of procedures as defined by this protocol exclusion criteria: 1. history of sickle-cell-related pain crisis within two weeks of study 2. pregnant or breast feeding 3. transfusion within last 90 days 4. creatinine \>1.5 x upper limit of normal 5. sgpt \> 2 x upper limit of normal 6. history of allergic reaction to arginine or citrulline product 7. requires chronic medication other than study drug that cannot be discontinued during the study period 8. unable to take or tolerate oral medications 9. unreliable venous access 10. noncompliant with regular care 11. participation in an investigational drug or medical device study within previous 30 days 12. in the opinion of the investigator is not a good candidate for participation in the study

Keywords: sickle cell disease
laboratory diagnosis of spontaneous bacterial peritonitis

Conditions: Spontaneous Bacterial Peritonitis

Summary: this study aims at evaluating the diagnostic accuracy of serum procalcitonin, pec index, modified wehmeyer, and mansoura scoring systems for sbp in cirrhotic patients with ascites

based on clinical diagnosis, sbp is commonly underdiagnosed because of its nonspecific or asymptomatic presentation. therefore, a diagnostic paracentesis should be performed in all cirrhotic patients with ascites who require emergency room care or hospitalization, who demonstrate signs/symptoms suggesting sbp, or who present gastrointestinal bleeding, in order to exclude sbp. several non-invasive methods were tried in many studies for sbp diagnosis, as alternatives to diagnostic paracentesis, e.g., fecal calprotectin. moreover, numerous scores were proposed for sbp diagnosis with variable accuracies, such as procalcitonin, esr, and crp (pec) index, the modified wehmeyer sbp scoring system, and mansoura scoring system. this study aims at evaluating the diagnostic accuracy of serum procalcitonin, pec index, modified wehmeyer, and mansoura scoring systems for sbp in cirrhotic patients with ascites. participants will be subjected to: clinical evaluation: medical history and physical examination, routine laboratory investigations, serum procalcitonin, ascitic fluid study, ascitic fluid culture with antibiotic sensitivity, abdominal ultrasonography. the following scores will be calculated: modified child pugh score, meld score, meld na score, pec index, modified wehmeyer score, and mansoura score.

Eligibility criteria:
inclusion criteria: * cirrhotic patients with ascites exclusion criteria: infections other than sbp. * malignancy. * antibiotic therapy before hospital admission. * chemotherapy or radiotherapy within 1 month before admission. * pancreatic diseases. * contraindication to paracentesis
a prospective study in chinese patients with lower extremity ankle fracture of oral anticoagulants to prevent venous thromboembolism (vte)

Conditions: Foot Ankle Injuries; Anticoagulants and Bleeding Disorders; Venous Thromboembolism

Summary: deep vein thrombosis (deep venous thrombosis, dvt) and pulmonary embolism, pulmonary embolism, pe) both collectively known as venous thromboembolism (vte) (venous thrombus embolism, vte), is a common clinical disease, and tremendous harmful. ankle fractures in patients requiring long-term bed braking, increase the incidence of lower extremity deep vein thrombosis, anticoagulant therapy as an important measures to prevent thrombosis in clinical widely accepted, however, the literature anticoagulation effect incision healing. whether to strike a balance between the two, to develop a foot fracture in accordance with the chinese characteristics of anticoagulant solution is we try to solve the problem. the purpose of this study is aimed at the use of oral anticoagulants and physical anticoagulant treatment knee far foot fracture patients randomized controlled studies in china.


Eligibility criteria:
inclusion criteria: * (1) year full 18 one full year of life (2) one side of ankle fractures, calcaneal fractures, the metatarsal bone fracutures will use the internal fixation treatment 3) participants must be able to normal conversation, and understand the problems in the "subject subjective questionnaire", and could provide feedback using the appropriate language. exclusion criteria: * 1)subjects did not provide a voluntary agreement 2) subjects participating in clinical research for pregnant or lactating women 3) has preoperative examination in the diagnosis of venous thromboembolism (vte) 4) in patients with preoperative oral antiplatelet/anticoagulation drugs for a long time. 5) surgery time fractures occur over time more than 3 weeks 6) patients exist pilon fractures (ao type 43-43 - b and c) and ankle multiple fractures, 7) pathological fractures (e.g., primary or metastatic tumors) 8) severe soft tissue injuries, open fractures or vascular injury or the combining bone fascia room syndrome; 9) multiple injuries, judge doesn't fit into the study by researchers, and other parts of the three or more than fracture 10) revision surgery (e.g., malunion, bone nonunion or infection) 11) merger of anticoagulant taboo disease, judge doesn't fit into the study by researchers, such as the active bleeding and clotting disorders, severe head trauma or acute spinal cord injury, platelet count \< 20 ╳ 109 / l, etc.; 12) patients with anesthesia and surgery patients with contraindications to 13) on pp shaaban drug allergy 14) patients may be poor compliance, the researchers determined doesn't fit into the daily (such as excessive drinking or smoking, taking drugs) 15) patients in the past three months participated in other clinical trials; 16) in patients with poor compliance, judge not according to the study by the researchers plan to complete the test, such as schizophrenia and dementia
a clinical trial comparing torcetrapib/atorvastatin to simvastatin in subjects with high cholesterol.

Conditions: Hyperlipidemia; Dyslipidemia; Hypercholesterolemia

Summary: the torcetrapib project was terminated on december 2, 2006 due to safety findings. cholesterol levels will be measured over six weeks in subjects being treated with two different kinds of cholesterol medications to see how the different treatments compare to one another.

for additional information please call: 1-800-718-1021

Eligibility criteria:
inclusion criteria: * eligible for statin treatment for ldl cholesterol by ncep guidelines exclusion criteria: * women who are pregnant or lactating, or planning to become pregnant. * subjects taking any drugs known to be associated with an increased risk of myositis in combination with hmg-coa reductase inhibitors. * subjects with significant liver or kidney disease or significant heart failure.
healthy for two, healthy for you

Conditions: Weight Gain; Pregnancy Related

Summary: investigators conducted a pilot feasibility and acceptability randomized controlled trial of a remotely delivered behavioral health coaching program in pregnancy and postpartum.

half of pregnant women are overweight or obese. obesity disproportionately impacts low-income women and women of racial and ethnic minorities. maternal obesity is linked with adverse perinatal outcomes, including gestational diabetes and preeclampsia, as well as longer-term health problems such as obesity in offspring and maternal cardiovascular disease. pregnancy provides a unique opportunity to engage women in improving their health behaviors because women are motivated to protect the health of their babies and have frequent interactions with the healthcare system. advances in behavioral weight management and obesity prevention have not yet been translated into real-world prenatal care settings. our team was recently supported by the national institute of diabetes and digestive and kidney diseases (niddk)-funded nutrition and obesity research center pilot and feasibility program to adapt an evidence-based telephonic health coaching program for pregnant women. investigators conducted 20 in-depth interviews with patients and providers to gain valuable feedback to inform the intervention design and delivery, and have put together a multi-disciplinary team to adapt the intervention. investiagtors developed the intervention specific for pregnancy and postpartum based on this feedback and are testing the intervention, healthy for two / healthy for you, to assess feasibility and acceptability.

Eligibility criteria:
inclusion criteria: * mothers: * bmi \>= 18.5 kg/m2 at time of eligibility screening * age \>=18 * able to provide informed consent * 12 weeks gestation or earlier * english speaking * insurance type * willing to provide address and \>=2 contact people * consistent use of a personal smartphone and willingness to use for health behavior tracking as part of the study * patient at a participating prenatal clinical site * access to internet (including public library and smartphone) * demonstrated ability to track caloric intake for 4 days * singleton pregnancy infants: • born during mother's enrollment in study exclusion criteria: * • type 1 or type 2 diabetes, pre-pregnancy or gestational diabetes, diagnosed prior to start of intervention (14 weeks gestation) * multiple fetuses * prior history of severe preeclampsia, pre-term birth (before 32 weeks gestation) * prior history of or current diagnosis of incompetent cervix * poorly controlled blood pressure (\>160/100) * unable to walk 1 block without pain, shortness of breath * serious medication condition hindering use of recommendations for pregnancy weight gain * not cleared by study's maternal-fetal medicine or treating obstetrician * planning to relocate from areas in next 2 years * psychiatric or substance use related hospitalization in past 1 year * (there is no exclusion criteria for the infants)
intraocular pressure and optic nerve sheath diameter changes in laparoscopic cholecystectomies

Conditions: Intraocular Pressure; Intracranial Pressure; Pneumoperitoneum

Summary: pneumoperitoneum created during laparoscopic surgeries has some effects on human physiology. increased intraabdominal pressure results in increased intrathoracic pressure, and eventually may result in increased intracranial and intraocular pressures. in this study we aimed to identify intraocular and intracranial pressure changes during the perioperative period due to the pneumoperitoneum created for laparoscopic cholecystectomy surgeries. intraocular pressure will be measured directly from the eye. intracranial pressure will be estimated by measuring optic nerve sheath diameter changes ultrasonographically.


Eligibility criteria:
inclusion criteria: * patients undergoing laparoscopic cholecystectomy * american society of anesthesiologists (asa) 1 or 2 physical status patients * elective surgeries exclusion criteria: * patients with glaucoma * asa 3 or above patients * emergency surgeries

Keywords: intraocular pressure optic nerve sheath diameter pneumoperitoneum laparoscopy laparoscopic surgery