Kornimate/medical-research-clean huggingface dataset:
black impact: the mechanisms underlying psychosocial stress reduction in a cardiovascular health intervention

Conditions: Cardiometabolic Syndrome; Physical Inactivity; Hypertension; Type 2 Diabetes; PreDiabetes; Obesity; Cardiovascular Diseases; Smoking; Sleep; Hyperlipidemias; Diet, Healthy; Blood Pressure

Summary: lower attainment of cardiovascular health (cvh), indicated by the american heart association's life's simple 7 (ls7; physical activity, diet, cholesterol, blood pressure, body mass index, smoking, glycemia) and life's essential 8 (le8; ls7+sleep) metrics, is a major contributor to black men having the shortest life-expectancy of any non-indigenous race/sex group. unfortunately, a paucity of literature exists on interventions aimed at improving cvh among black men. the team of clinician scientists and community partners co-developed a community-based lifestyle intervention titled black impact: a 24-week intervention for black men with less-than-ideal cvh (\<4 ls7 metrics in the ideal range) with 45 minutes of weekly physical activity, 45 minutes of weekly health education, and engagement with a health coach, group fitness trainer, and community health worker. single-arm pilot testing of the intervention (n=74) revealed high feasibility, acceptability, and retention and a 0.93 (95% confidence interval: 0.40, 1.46, p\<0.001) point increase in ls7 score at 24 weeks. secondary outcomes included improvements in psychosocial stress (i.e., perceived stress, depressive symptoms), patient activation, and social needs. thus, robustly powered clinical trials are needed to determine the efficacy of black impact and to evaluate the underlying interpersonal and molecular pathways by which black impact improves psychosocial stress and cvh. thus, the investigators propose a randomized, wait-list controlled trial of black impact. this novel, community-based intervention to provide a scalable model to improve cvh and psychosocial stress at the population level and evaluate the biological underpinnings by which the intervention mitigates cardiovascular disease risk. the proposed study aligns with american heart association's commitment to addressing cvh equity through innovative, multi-modal solutions.


Eligibility criteria:
inclusion criteria: * the inclusion criteria are: 1) black men (self-report); 2) adult age 18 years or older; 3) life's essential 8 total average score \< 80; 4) english speaking; and 5) lives in metropolitan columbus, ohio. exclusion criteria: * healthcare provider-imposed limitations on physical activity.
a randomized cross-over trial of comparison between robotic and laparoscopic suturing for gastric defect by novices

Conditions: Surgical Suturing for Closure of Gastrotomy; Laparoscopic Suturing; Robotic Surgical Suturing

Summary: to compare the performance of surgical suturing using da vinci robotic surgical system and conventional laparoscopic surgical suturing among novice

background da vinci® robotic surgical system (dvrss) has been widely applied to perform complex minimally invasive surgical procedures across different specialties. this study aimed to investigate the impact of dvrss on surgical proficiencies among inexperience novice surgeons and compared to conventional laparoscopic surgery. methods twenty medical students (n=20) without surgical experience were enrolled. after a constructive training for basic surgical techniques, participants were randomly allocated into dvr or laparoscopy group. participants were asked to close five cases (also named five tasks) of a 2cm long incision on pig stomach by using dvr or laparoscopy. surgical time, successful closure rate and pneumatic bursting pressure of gastric incision withstanding were recorded. in addition, participant performance and workload were quantified by using performance score, scales of global rating scale assessment (gsa) and nasa-task load index (nasatli).

Eligibility criteria:
inclusion criteria: * medical students with no prior surgical experience exclusion criteria: * surgeons * age \ 60 * disability and not able to control the da vinci robot through the console
pharmacokinetics evaluation of recombinant coagulation factor viii injection in subjects with hemophilia a.

Conditions: Hemophilia A

Summary: this is a multi-center, open-label, randomized study. participants will be assigned to a or b groups with a scale of 1:1 , i.e. infuse study drug followed by xyntha (group a), or the alternate sequence (group b). all participants who completed the study will enter the prophylactic therapy study.


Eligibility criteria:
inclusion criteria: 1. hemophilia a. 2. fviii:c \<1%. 3）12 and 65 years old. 4）has received fviii treatment and the treatment exposure days ≥100. 5）has bleeding treatment records of at least 3 months before randomization. 6）fviii inhibitor assay results is negative. 7） subjects should agree to use an adequate method of contraception during the study. 8）understood and signed an informed consent form. 9）has not received an treatment of any fviii within 4 days before the first dose. 10）non-bleeding state. exclusion criteria: 1. has a history or family history of blood coagulation factor viii inhibitor. 2. has other coagulation dysfunction diseases in addition to hemophilia a. 3. hiv positive. 4. plan to receive surgery during the trial. 5. has used immunomodulator within one weeks before the first dose，and less than 7 half-life periods. 6. known to be allergic to experimental drugs or any excipients. 7. severe anemia and need blood transfusion. 8. serious liver or kidney damage. 9. serious heart disease. 10. uncontrollable hypertension. 11. has participated in other clinical studies within one month before the first dose. 12. the researchers believe that it is not suitable for participants.
augsburg longitudinal plasma study for the evaluation of liquid biopsy as diagnostic tool.

Conditions: Characteristics Disease; Metastatic Cancer; Solid Tumor

Summary: a prospective observational trial of patients with metastatic cancer of various entities which aims at both clarifying the significance of liquid biopsy and establishing a foundation for translational research.

alps is a prospective observational trial to assess liquid biopsy as diagnostic tool in patients with various metastatic neoplasms. liquid biopsy will be correlated not only with the tissue biopsy, but also to imaging modalities and classical tumor markers. in addition, the study aims to investigate clonal heterogeneity and evolution of different cancers during patient treatment courses. a third aspect of the study is to survey and assess patients' knowledge about biomarkers and personalized medicine in general and about liquid biopsy as a new diagnostic tool.

Eligibility criteria:
inclusion criteria: * written informed consent * age ≥ 18 years * histopathologically confirmed metastatic or locally advanced cancer * no curative treatment options, except for germ cell tumors * written agreement to be followed up at augsburg university medical center * signed written informed consent for the biobank augsburg (biobank-a) * willing to undergo treatment according to standard of care * availability or anticipated availability of tumor tissue at time point of inclusion * anticipated life expectancy of at least 3 months at time point of trial inclusion exclusion criteria: * psychological condition that would preclude informed consent * additional tumor treatment between acquisition of tumor tissue and trial inclusion
ces in the elderly with generalized anxiety disorders

Conditions: CES; Anxiety Disorders and Symptoms

Summary: the study aimed to investigate whether cranial electrotherapy stimulation(ces) could benefit anxiety symptoms, depressive symptoms, quality of sleep and quality of life in elderly patients with anxiety disorder.

several studies have shown cranial electrotherapy stimulation (ces) could decrease depression and anxiety symptoms in patients with mood disorder. however, none study so far focused on the elderly population to investigate the anti-depressant and anxiolytic effect in elderly patient with anxiety disorder. hence, this pilot study aims to assess the safety and efficacy of ces on anxiety symptoms, depressive symptoms, sleep quality and life quality in elderly patient with anxiety disorder. the study was an open-label, one arm study. the study aimed to investigate whether cranial electrotherapy stimulation(ces) could benefit anxiety symptoms, depressive symptoms, quality of sleep and quality of life in elderly patients with anxiety disorder.

Eligibility criteria:
inclusion criteria: * aged 60 to 85 years old * anxiety disorder confirmed by mini-international neuropsychiatric interview (mini) * ham-a score greater than 17 points * ham-d score lower than 17 points * mini-mental state examination score of 24 or more * no psychiatric medication adjustment within 3 months. exclusion criteria: * comorbid with another axis i psychiatric disorder, like schizophrenia, substance use disorder or other major mental illness screened by mini-international neuropsychiatric interview (mini) * contraindications for ces * implanted brain medical devices or mental in the head * history of seizures * history of intracranial neoplasm or surgery * severe head injuries * cerebrovascular diseases * arrhythmia or with pacemaker implantation * used to receive brain stimulation therapy.
effect of pectointercostal+esp block on postoperatif analgesia in open heart surgery

Conditions: Postoperative Pain

Summary: american society of anaesthesiologist physical status ii-iii, aged between 18-65, 60 patients which underwent open cardiac surgery will recruited to this study. these subjects will ultrasound (usg) guided erector spinae block will perform at t6 level (bilaterally) and pectointercostal plane block at 4-5 intercostal space to the all patient under general anaesthesia. totally bupivacaine %0.25 2.5 mg/kg will use blocks and 1 ml epinephrin will add to the each local anesthetic solutions. 10 ml %0.25 bupivacain will apply to the chest tube area at the end of surgery. 0.1 microgram/kg morphine will apply intravenously at last 30 minutes of surgery postoperative analgesia to all patients. postoperative pain assessment will perform with visual analog scale (vas)

american society of anaesthesiologist physical status ii-iii, aged between 18-65, 60 patients which underwent open cardiac surgery will recruited to this study. the patients were randomly allocated into two groups (1:1), via a computer-generated randomization list. ultrasound (usg) guided erector spinae block will perform at t6 level (bilaterally) and pectointercostal plane block at 4-5 intercostal space to the 30 patients under general anaesthesia in group block and block will not perform to the control group. sevoflurane+remifentanil and o2/air combination will perform to the all patients during the surgery. totally bupivacaine %0.25 2.5 mg/kg will use for blocks and 1 ml epinephrin will add to the each local anesthetic solutions in each side.10 ml %0.25 bupivacain will apply to the chest tube area at the end of surgery. 0.1 microgram/kg morphine intravenously will apply for postoperative analgesia to the all patients at last 30 minutes of surgery. postoperative pain assessment will perform with visual analog scale (vas). vas, morphine consumption and complications will record.paracetamol 10 mg/kg will repeat to the all patients at the 12th of postoperative period, intravenously. the patient controlled anesthesia with morphin will apply to the all patients. if the vas score is higher than 4, the rescue analgesic diclofenac na 75 mg will administer intravenously.

Eligibility criteria:
inclusion criteria: * asa ii-iii patients * the patients who will operate for open heart surgery exclusion criteria: * the patients with coagulopaty * allergy with local anesthetics * infection at the injection sites * obesity (bmi \>35kg/m2) * liver and/or kidney failure
mitochondria and schizophrenia: effects of antipsychotic drugs

Conditions: Schizophrenia

Summary: the investigators will investigate 1. the relationships between oxidative stress-, apoptosis-related markers, mitochondria dna copy numbers and the clinical psychopathology of schizophrenia, including severity of positive and negative symptoms, obesity and metabolic syndrome. 2. the relationships between aberrant mitochondria genes (single nucleotide polymorphism of d-loop region-related genes and haplogroup n9a), disc1 gene polymorphism, and clinical phenotypes in taiwanese populations. 3. whether these biological markers could be as clinical markers in schizophrenia for a long-term follow-up study.

in past study, we had shown that there were significant differences in serum lpo (lipid peroxidation) and thiol levels between patients with schizophrenia and healthy controls. for patients taking risperidone, there were significant decreases in serum thiol levels. in addition, there were also significant differences in age of onset of ppar gamma coactivator 1α (pgc-1α) polymorphism for schizophrenia patients. therefore, we want to know the relationships between oxidative stress-, apoptosis-related markers, mitochondria dna copy numbers and the clinical psychopathology of schizophrenia, including severity of positive and negative symptoms, obesity and metabolic syndrome. in past study, we also found that there were significant differences in 10 snps located in the d-loop region-related genes between patients and healthy controls. three snps could be found in mitomap data, but another seven snps not been found in the mitomap and they could be more confirmed. in addition, tanaka et al. found that haplogroup n9a was related to diabetes and metabolic syndrome in asia. therefore, we were interested to clarify the relationships between above related mitochondria genes and clinical phenotypes in taiwanese populations,. in addition, we also want to see whether these biological markers could be as clinical markers in schizophrenia for a long-term follow-up study.

Eligibility criteria:
inclusion criteria: 1. schizophrenic patients will be recruited in psychiatric inpatients and outpatients departments according to dsm-iv criteria by a semi-structured interview. the assessment will be done by two senior psychiatrists. the intra- rater and inter-rater reliability will be done before this project started. 2. the patients had the ability to complete the written inform consent. exclusion criteria: 1. alcohol abuse or dependence 2. smoking more than 1 pack per day 3. concurrent use of mood stabilizer or beta-blocker

Keywords: schizophrenia oxidative stress mitochondria
diagnostic accuracy of fdg pet/ct of cranial arteries in gca

Conditions: Giant Cell Arteritis

Summary: a case-control study to evaluate the diagnostic accuracy of fdg uptake in cranial arteries by fdg pet/ct in the diagnosis of giant cell arteritis.

although older studies argue that fdg pet/ct cannot demonstrate inflammation in cranial arteries, e.g. temporal and maxillary arteries, the resolution of modern pet systems may have improved, making a case for fdg pet/ct. fdg pet/ct is increasingly used in giant cell arteritis (gca) diagnosis due to its excellent diagnostic accuracy considering large-vessel involvement. in case of uncommon distribution of vessel involvement or marginally increased large-vessel fdg uptake, fdg pet/ct-specificity may be compromised. hence, recognising fdg uptake in cranial arteries potentially adds to fdg pet/cts diagnostic accuracy. objectives to evaluate the diagnostic accuracy of conventional fdg pet/ct of the cranial arteries in the diagnosis of gca. methods in a cohort of consecutively included glucocorticoid-naïve patients suspected of new-onset gca, patients with a clinical gca diagnosis will be identified. conventional fdg pet/ct and vascular ultrasound(us) was performed before treatment. patients were referred for a temporal artery biopsy (tab). controls are age-(+/- 3 years) and sex-matched malignant melanoma (mm) patients who had a follow-up metastatic-disease-free fdg pet/ct ≥6 months after mm resection. images will be assessed by 5 nuclear medicine physicians blinded to clinical symptoms and findings. temporal (ta), maxillary (ma) and vertebral (va) arteries will be visually assessed. arterial fdg uptake more than fdg uptake in surrounding tissue is considered positive. sensitivity, specificity and interreader agreement will be evaluated.

Eligibility criteria:
inclusion criteria: cases: * 1) age ≥50 years, 2) crp\>15mg/l or esr\>40mm/h, 3) either a) cranial symptoms, b) new-onset extremity claudication or c) weight loss \>5 kilograms or fever\>38oc for \>3 weeks and a clinical diagnosis of giant cell arteritis judged by expert rheumatologist. controls: * age-(+/-3 years) and sex-matched malignant melanoma (mm) patients * follow-up metastatic-disease-free fdg pet/ct ≥6 months after mm resection exclusion criteria: * previous diagnosis of polymyalgia or giant cell arteritis * immunosuppresive treatment within last month

Keywords: positron emissions tomography diagnostic accuracy case-control
treatment frequency and satisfaction in patients with advanced prostate cancer

Conditions: Prostatic Neoplasms

Summary: patients with advanced prostate cancer usually receive some kind of pharmaceutical castration or undergo surgical castration. at the investigators department the pharmaceutical treatment is most often given with a 3 month interval. over the last few years new drugs, which allow for lees frequent treatment, have been developed. the purpose of this study is to assess how the treatment affects patients and if our current patients would prefer to receive treatment at different intervals than they do at the present time. at the same time the investigators will assess how surgical treatment affects our patients. this will be assessed by patient questionnaires administered at our clinic.


Eligibility criteria:
inclusion criteria: * a diagnosis of advanced prostate cancer * receiving hormone manipulation treatment (pharmaceutical castration) or having undergone surgical castration (orchiectomy) exclusion criteria: * inability to read/write danish

Keywords: hormone treatment castration orchiectomy treatment frequency treatment satisfaction side effects
supplements for controlling resistance to insulin

Conditions: Obesity; Diabetes Mellitus, Type 2

Summary: the purpose of this study is to evaluate the effects of a combination of hydroxcycitrate (hca) and niacin-bound chromium, in conjunction with nutrition education, over a twelve week period. participants will be evaluated with regard to bmi, percent body fat, insulin activity, and hunger.

the prevalence of obesity among youth has increased dramatically in recent years. parallel to the increased rates of pediatric obesity, overweight children present clinically with adiposity related comorbidities such as insulin resistance and type 2 diabetes. the prevailing recommendations for overweight youth are to increase physical activity levels and limit energy intake in order to improve body composition. currently there is little empirical evidence to support the efficacy of these recommendations. alternatively, evidence in adults suggests that nutritional supplementation with (-) hydroxycitric acid (hca), an organic acid found naturally in citrus fruits, and chromium may lead to favorable changes in body composition and improve glucose regulation. to date, these issues have not been tested in youth. therefore, the purpose of the present investigation is to examine the effects of a nutritional education program combined with either hca + chromium or placebo on measures of body composition and glucose regulation in overweight adolescents.

Eligibility criteria:
inclusion criteria: * age * all subjects will be between 13 and 17 years of age * overweight * all subjects will be overweight as defined by an age \& sex-specific body mass index ≥ 85th percentile based on cdc bmi growth charts \[us department of health and human services, 2000\], calculated by epi info software, version 3.3. exclusion criteria: * presently taking any prescribed medication(s) or diagnosed with any syndrome or disease that could influence dietary intake, body composition and fat distribution, or insulin action or secretion. * previously diagnosed with any major illness since birth (e.g. sever intrauterine growth retardation, chronic birth asphyxia, cancer). * children with type 1 and/or type 2 diabetes will be excluded are referred to a physician. * currently involved with any dietary, exercise, or weight loss program or have been in the 6 months prior to participation. * unexplained weight loss or gain in the prior six months. * oral contraception use in sexually active females * children who live further than 20 miles away from the usc health science campus (hsc).
effect of bis monitoring on propofol usage during elective bronchoscopy

Conditions: Pulmonary Diseases

Summary: in this research, the investigators will asses the effect of bis monitoring on propofol usage during elective flexible fiberoptic bronchoscopy. the investigators will examine whether use of bis monitor enables reduction of sedative dose during bronchoscopy. the investigators will also examine whether administration of lower total sedative dose enables prevention of possible complications.

during flexible fiberoptic bronchoscopy (ffp) a narrow optic tube is inserted via the mouth or nose into the airways. this allows direct visualization of the airways as well as taking different samples. in addition, this procedure allows opening of airway obstruction. administration of sedation during ffp is important, since this diminishes patient discomfort and body movements. it also lessens the untoward physiologic response to airway manipulation. in addition, patients requiring repeated examinations may refuse if they have suffered an unpleasant experience. ffp is usually a brief procedure (several minutes up to an hour). therefore, it is advantageous to use short acting drugs in order to shorten the prolonged post procedural monitoring and allow rapid patient discharge. several clinical trials have shown the superiority of propofol over midazolam for sedation during bronchoscopy regarding recovery of alertness, memory \& motor function. propofol is a sedative-hypnotic with rapid onset and short duration. using propofol, one can achieve rapid onset of sedation and faster recovery. propofol given in boluses of 10-20 mg was found as an effective dose to reach bis target values. awareness is the postoperative recollection of events occurring during general anesthesia. bis is a monitor of anesthetic depth approved by the fda. it incorporates time-domain, frequency-domain and bi-spectral analysis of the eeg. this analysis is displayed as a dimensionless number between zero (deep anesthesia) and 100 (awake). bis values between 80-90 represent values corresponding to light/moderate sedation

Eligibility criteria:
inclusion criteria: * over 18 years old * undergoing flexible fiberoptic bronchoscopy for lung tissue biopsy, airway lavage or opening of airway obstruction. exclusion criteria: * patient refusal/ inability to sign informed consent. * age under 18 years of age. * ventilated patients (via endotracheal tube or tracheostomy). * known allergy for one of the anesthetic drugs. * patients who suffered a stroke and/or have other neurological diseases. * hemodynamically unstable patients (sbp below 90mmhg or above 180mmhg).