Kornimate/medical-research-clean huggingface dataset:
study to evaluate performance, usability, safety of microwave technology when collecting data from patients with stroke

Conditions: Stroke; Healthy

Summary: this is a prospective, open, multicenter study that will enroll patients admitted to and hospitalized at the stroke unit due to diagnosed stroke and healthy volunteers. the main purpose of the study is to evaluate the ability of the microwave technology to deliver adequate measurement data.

after written informed consent has been acquired a physical examination will be performed followed by confirmation of the inclusion/exclusion criteria. after subject enrollment the microwave measurement will be performed. the procedure will take approximately 15 minutes (the duration of the actual measurements is \< 1 minute) and will not interfere with the patient's standard of care at the stroke unit. the measurement data will be evaluated for the presence of signal artifacts. the diagnostic ability of the device will be evaluated using a leave-one-out cross validation method with the ct diagnosis as ground truth. microwave signals are sensitive to the dielectric parameters of the investigated object. in biological matter this is often related to amount of water. brain tissue has different dielectric properties from blood. the physiological changes inside the brain that occurs as a result of a stroke will change the dielectric parameters.

Eligibility criteria:
inclusion criteria: (group a) * signed informed consent form * patient diagnosed (by ct) with ischemic stroke, within 24 hours of stroke onset * patient should be ≥ 18 years of age (group b) * signed informed consent form * patient diagnosed (by ct) with hemorrhagic stroke, within 48 hours of stroke onset * patient should be ≥ 18 years of age (group c) * signed informed consent form * subject should be ≥ 18 years of age exclusion criteria: (group a+b) * pregnant or nursing woman * woman of child bearing potential and not taking adequate contraceptive precautions * patient that has already received thrombolytic treatment * patient participating in any other clinical study that could interfere with the result in the present study * patient diagnosed with a condition associated with risk of poor protocol compliance * any other condition or symptoms preventing the patient from entering the study, according to the investigator´s judgment * any patient that according to the declaration of helsinki is deemed unsuitable for study enrollment (group c) * pregnant or nursing woman * woman of child bearing potential and not taking adequate contraceptive precautions * subject participating in any other clinical study that could interfere with the result in the present study * any other condition or symptoms preventing the subject from entering the study, according to the investigator´s judgment * any subject that according to the declaration of helsinki is deemed unsuitable for study enrolment
impact of adapted mirror therapy on individuals with hemiparesis of the upper limb following a stroke

Conditions: Hemiparesis

Summary: patients with upper limb hemiplegia after stroke, who were admitted in the department of rehabilitation medicine, were enrolled. the study lasted 30 days for each participant. the patients enrolled were randomly divided into the experimental group and the control group, all under routine rehabilitation therapy. additionally, the patients in the experimental group were given modified mirror therapy. on day 1 and day 30, patients' upper limb function were compared.

upper limb hemiparesis is a motor and sensory disorder that occurs after stroke, with an incidence rate of up to 55% to 75%. this was a randomized controlled trial. patients with upper limb hemiplegia after stroke, who were admitted in the department of rehabilitation medicine, were enrolled. the study lasted 30 days for each participant. the patients enrolled were randomly divided into the experimental group and the control group, all under routine rehabilitation therapy. additionally, the patients in the experimental group were given modified mirror therapy. on day 1 and day 30, patients' upper limb function were compared.

Eligibility criteria:
inclusion criteria: * meeting the diagnostic criteria of stroke. * the first-onset stroke. * presenting with unilateral upper limb dysfunction, within brunnstrom stage ⅱ to ⅳ on the affected side, and ash-worth score ≤2. * no obvious cognitive impairment, with mini-mental state examination (mmse) score \>21 points. * national institutes of health stroke scale (nihss) score \>4 points. * stable vital signs, no severe diseases such as cancer, liver or kidney disorders. * aged 35-70 years. * courses of diseases 2-6 weeks. exclusion criteria: * presence of aphasia, apraxia, or hemispatial neglect. * presence of hearing, vision, or comprehension impairments that hinder diagnosis and treatment. * complicate with traumas, fractures, or other progressive neuro-muscular system diseases. * severe spasticity in the upper limbs. * severe bone, joint, or muscle deformities or lesions. * history of mental illness.
phototherapy in persons with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the current study examines the effect of phototherapy equipped with narrow band uvb lamps on vitamin d production in persons with ms.

participants will be exposed to phototherapy according to the 2014 guidelines issued by the american academy of dermatology 3 days per week over an 8-week period.

Eligibility criteria:
inclusion criteria: * female with multiple sclerosis exclusion criteria: * inability to stand still in a stabilized fashion without risk of falling for up to 6 minutes * known medical history of calcium disorder or knowledge of high calcium levels * known medical history of hyper-parathyroidism * current supplementation with oral vitamin d * known allergy to vitamin d * history of cancer of any type including but not limited to skin cancer * obesity defined as bmi \> 30 * known history of fat malabsorption conditions (i.e., steatorrhea) * current use of anti-epileptic medication * current use of glucocorticoids * fitzpatrick skin types i and vi using the fitzpatrick skin type analysis * recent use of tanning facilities
the effect of milk and meat on igfs in prepubertal boys

Conditions: Growth Disorders; Metabolic Syndrome

Summary: the objective of the study is to examine whether a 7-day high protein intake from either milk or meat in healthy, prepubertal children can increase fasting levels of serum igf-i, igfbp-3 and igf-i/igfbp-3 as well as insulin, glucose and homa insulin reststance, homa beta cell function and amino acids.

the objective of the study is to examine whether a high protein intake (pi) from either milk or meat, at a level often seen in late infancy, in healthy, prepubertal children can increase fasting levels of serum igf-i, igfbp-3 and igf-i/igfbp-3 as well as insulin, glucose and homa insulin reststance, homa beta cell function and amino acids. igf-i levels are positively associated with growth velocity in children and some studies suggest that a high animal pi can stimulate growth. during protein deprivation igf-i decrease, but it is unknown whether a high pi can increase s-igf-i in well-nourished children. insulin is also a growth factor, and studies have found that postprandially, milk possess some insulinotrophic effect not related to its carbohydrate content. however, the effect on fasting insulin in children is unknown. design: twenty-four 8-y-old boys are asked to take either 1.5 l of skimmed milk (n=12) or the same amount of protein as 250 g low fat meat (n=12) daily for seven days. the remaining diet they can choose freely. at baseline and after seven days, anthropometrical variables are measured, diet is registered (3-d weighed records), and the blood analytes are determined after fast.

Eligibility criteria:
inclusion criteria: * habital milk intake more than 500 ml/d * willing to increase intake of milk or meat considerably for one week exclusion criteria: * chronic illnesses * children who suffer from any condition likely to affect their protein metabolism or growth

Keywords: children milk meat animal protein growth factors igf-i igfbp-3 insulin
cohort study on the treatment of severe pneumonia with traditional chinese medicine

Conditions: Community-Acquired Infections

Summary: this is a multicenter, prospective cohort study, with syndrome differentiation and treatment of traditional chinese medicine as the exposure factor. patients using syndrome differentiation of traditional chinese medicine combined with conventional treatment of western medicine are classified as the treatment cohort of integrated chinese and western medicine, and patients using conventional treatment of western medicine only are classified as the treatment cohort of western medicine

severe pneumonia is a severe respiratory disease with high mortality, many complications and poor prognosis. traditional chinese medicine has certain curative effect in the adjuvant treatment of severe pneumonia, but there is a lack of systematic tcm syndrome differentiation scheme and its curative effect evaluation in the real medical environment. the cohort study on the efficacy of tcm syndrome differentiation scheme in the adjuvant treatment of severe pneumonia is conducive to providing new evidence for the optimization and evidence-based evaluation of tcm treatment scheme for severe pneumonia. therefore, this study took severe pneumonia as the research object, standardized use of traditional chinese medicine diagnosis and treatment scheme as the exposure factor, carried out a multi center prospective cohort study, used the 90 day mortality, 28 day mortality, treatment failure rate, etc., to evaluate the clinical efficacy and safety of integrated traditional chinese and western medicine in the treatment of severe pneumonia, and provided evidence for the application and promotion of traditional chinese medicine in severe pneumonia.

Eligibility criteria:
inclusion criteria: * it met the diagnostic criteria of severe pneumonia; * age ≥ 18 years old, regardless of gender. * voluntary treatment. * sign the informed consent form. exclusion criteria: * pregnant or lactating women; * patients with mental illness who are unable to cooperate or unwilling to cooperate with follow-up; * those who are participating in clinical trials of other drugs; * known allergic to therapeutic drugs.

Keywords: community-acquired infections traditional chinese medicine cohort study
postural assessment by photogrammetry

Conditions: Osteoporosis

Summary: this study aimed to measure the degree of thoracic kyphosis in elderly women with those affected by osteoporosis in the spine, through photogrammetry computer and check the difference between the values obtained with the assumption of greater thoracic kyphosis in osteoporotic women.

the decrease in bone density of vertebrae leads to a reduction of the anterior vertebral bodies, resulting in compression and collapse of vertebrae, with narrowing of intervertebral disc spaces and, determining a number of deformities in the spine and postural changes, among which can highlight the increase in thoracic kyphosis. this becomes significantly higher with age and after menopause, defined as an increase in curvature in the sagittal plane of the thoracic spine. radiographic images have been used for the measurement of thoracic kyphosis, but with some drawbacks of this method such as radiation exposure, radiographic image quality unsatisfactory hampering its analysis and the lack of equipment in the physical environment to monitor clinical evolution of the treatment, causing thus the search for noninvasive methods for evaluating the curves of the spine, including the photogrammetry computed. according to the american society of photogrammetry, the computed photogrammetry is "the art, science and technology of information on physical objects and environment through processes of recording, measuring and interpreting photographic images and patterns of electromagnetic radiant energy and other sources." it is a widely used tool for assessment by quantifying the postural changes through the application of photogrammetric principles to photographic images obtained in body movements, adding to the diagnostic evaluation for physical therapy in different areas.

Eligibility criteria:
inclusion criteria: * age between 50 and 80 years * with examination of bone densitometry * with densitometric diagnosis of osteopenia in the first group, the second group for osteoporosis, * willing to participate in the study exclusion criteria: * presence of severe scoliosis, ankylosing spondylitis, obesity * presence of neurological diseases serious

Keywords: osteoporosis kyphosis photogrammetry
the brainfood trial to prevent recurrent hepatic encephalopathy.

Conditions: Cirrhosis; Ascites; Liver Diseases; Frailty; Sarcopenia; Hepatic Encephalopathy

Summary: this study is being completed for patients with cirrhosis, including patients with a prior history of hepatic encephalopathy (he) to evaluate the feasibility and benefits of medically-tailored meals as an intervention. patients will be enrolled from the university of michigan and will complete the baseline assessments in-person or remotely. in addition participants will complete study related materials before, during and after treatment with medically-tailored meals (mtm). after completing the study meals, participants will return for follow-up or have this visit completed remotely as well as have an observational period for 12 more weeks.


Eligibility criteria:
inclusion criteria: * diagnosis of cirrhosis will be based upon: 1. liver biopsy, or 2. history of cirrhosis complication: ascites, variceal bleeding, hepatic encephalopathy, or 3. 2 of the following 4 criteria: 1. ultrasound, computed tomography (ct), or magnetic resonance imaging (mri) findings of cirrhosis (cirrhotic appearing liver, splenomegaly, varices, ascites) 2. fibroscan liver stiffness score \>13 kilopascals (kpa) 3. laboratory testing: aspartate aminotransferase/platelet ratio index (apri) \>2.0 4. ct, mri or esophagogastroduodenoscopy (egd) showing presence of esophageal varices * patients with history of \> grade 2 he within 180 days of enrollment based on review of clinical documentation verifying the event. if a description of he symptoms is provided in clinical documentation, but it is unclear if it meets grade 2 criteria, the principal investigator will assess the clinical documentation and provide an he grade. exclusion criteria: * non-english speaking * model for end-stage liver disease (meld) score \> 20 * pregnancy (self-reported) * unable or unwilling to provide consent * history of liver transplant * current or planned admission to a nursing facility * serum creatinine \> 2.0 milligrams per deciliter (mg/dl) (with the exception that we will include patients with a serum creatinine \> 2.0 mg/dl if they are receiving hemodialysis) * disorientation at the time of enrollment * barcelona-clinic liver cancer (bclc) stage d hepatocellular carcinoma with child-turcotte-pugh (ctp) class c * history of eating disorder

Keywords: nutrition
almitrine in covid-19 patients with ards treated by hfno

Conditions: ARDS; Hypoxemia

Summary: the purpose of this study is to determine the effects of almitrine administration on oxygenation in covid-19 patients with acute respiratory distress syndrome treated by high-flow nasal canula oxygen therapy as first-line ventilatory support.

from december 2019, the emergent coronavirus sarscov-2 is responsible for the worldwide pandemic of coronavirus disease (covid-19). although sarscov-2 infection is mainly responsible for mild respiratory symptoms, up to 70% of hospitalized patients with covid-19-related pneumoniae may develop severe respiratory disease, progressing to acute respiratory distress syndrome (ards). these patients may experience severe but well-tolerated hypoxemia, so-called "happy hypoxemia" which may be related to blunted hypoxic vasoconstriction. almitrine is a selective pulmonary vasoconstrictor that has been reported to improve the oxygenation in ards patients by increasing hypoxic pulmonary vasoconstriction. some small case series reported that the use of almitrine in mechanically ventilated covid-19 patients with ards improved oxygenation. given the "happy hypoxemia" phenomenon, it has been suggested to use high-flow nasal canula therapy (hfno) as first-line ventilatory support in covid-19 patients with ards, since the risk of aerosolization with hfno was similar to that with standard oxygen therapy and lower to that with non-invasive ventilation. however, the effects of almitrine in spontaneously breathing patients with ards has not been reported so far. thus, the main goal of this study is to investigate the effects of almitrine on oxygenation of covid-19 patients with ards treated by hfno as first-line ventilatory support. the second goal of this study is to determine the effects of almitrine on respiratory mechanics and hymodynamics.

Eligibility criteria:
inclusion criteria: 1. patients treated by high-flow nasal canula oxygen 2. positive covid-19 real-time reverse transcriptase-polymerase chain reaction assay in nasal swabs 3. persistent severe hypoxemia after awake prone positioning defined by one or more of the following criteria: 1. spo2 \ 80% 2. pao2/fio2 ratio \ 80% 4. patients treated by almitrine exclusion criteria: 1. age \<18 years old and pregnant women 2. patients under legal protection 3. patients with a do not intubate or do not resuscitate decision 4. patients requiring immediate invasive mechanical ventilation 5. contraindication to almitrine 6. poor echogenicity
study comparing tigecycline vs. levofloxacin in subjects hospitalized with community-acquired pneumonia

Conditions: Community-Acquired Infections; Bacterial Pneumonia; Cross Infection

Summary: to compare the efficacy and safety of iv tigecycline to iv levofloxacin in the treatment of subjects with cap requiring hospitalization.


Eligibility criteria:
inclusion criteria: * male and female subjects ≥ 18 years of age and in bulgaria only ≤ 70 years of age * subjects hospitalized with cap with a severity that requires iv antibiotic treatment for at least 7 days * the presence of fever (within 24 hours before randomization) exclusion criteria: * any concomitant condition that, in the opinion of the investigator, would preclude an evaluation of a response or make it unlikely that the contemplated course of therapy could be completed (eg, life expectancy \<30 days). * hospitalization within 14 days before the onset of symptoms. * residence in a long-term care facility or nursing home ≥14 days before the onset of symptoms.

Keywords: bacterial pneumonia
early rabies vaccine immunization in primary school children

Conditions: Rabies Prevention

Summary: 700 male and female healthy school-children (age 5 to 8) in thailand were randomized to receive 2 or 3 primary rabies vaccine doses (pcecv, rabipur) given intradermally in a dose of 0.1ml into the skin in the deltoid region. in a subset of 100 children blood was taken for rabies virus neutralizing antibody determination on day 49. all subjects were randomized to receive 2 booster doses (the recommended vaccination schedule for pre-immunized individuals in case of an exposure) on days 0 and 3, one, three or five years later. blood was taken before and after booster for up to one year.safety and tolerability of the vaccine was assessed and persistence of immune response up to 1 year after the booster doses.


Eligibility criteria:
inclusion criteria: male and female 5-8 years old school children will be included in the study if: * their parents or legal guardians have given the written informed consent prior to study entry; * they are in good health at time of study entry as determined by medical history, physical examination and clinical judgment of the investigator; * they are available for all the visits scheduled in the study. exclusion criteria: subjects are not to be enrolled into the study if: * they have a history of rabies immunization; * they have an acute infectious disease at the time of study entry; * they are under treatment with parenteral and/or oral steroids, immunosuppressive drugs, phenytoin or other specific anti-inflammatory drugs, or have taken chloroquine during the two month period before enrolment; * they have a known immunodeficiency or an autoimmune disease; * they have a known hypersensitivity to neomycin, tetracycline or amphotericin-b; * they have planned surgery during the first study period (49 days); * they are participating in any other trial of an investigational agent; * they have any condition which in the opinion of the investigator, might interfere with the evaluation of the study objectives. * the family plans to leave the area of the study site before the end of the study period.

Keywords: rabies pcecv pre-exposure immunization intradermal children
biodegradable biliary stent for post operative cystic duct leakage

Conditions: Cyst

Summary: endoscopic sphincterotomy and temporary stenting is a routine treatment for post cholecystectomy cystic duct leakage. the draw back is that the plastic stent need to be removed later in a second intervention. our studies with animal models have demonstrated that biodegradable biliary stent is at least as good as conventional plastic stent to heal that kind of leakage. in this pilot study the biodegradable biliary stent is inserted endoscopically to patients with confirmed cystic duct leakage to demonstrate the efficacy in human setting.


Eligibility criteria:
inclusion criteria: * patients with confirmed post cholecystectomy cystic duct leakage requiring endoscopic treatment

Keywords: cystic duct leakage
host dysregulation-driven sepsis prediction model

Conditions: Sepsis

Summary: the aim of this study is to identify risk factors associated with sepsis and to construct a predictive model for sepsis. this will provide an objective theoretical and empirical foundation for the diagnosis, assessment, and management of sepsis in our country.the primary questions addressed are: what are the risk factors for the development of sepsis? how do we improve the prognosis of sepsis?


Eligibility criteria:
inclusion criteria: * patients with infection or suspected infection exclusion criteria: * patients with autoimmune diseases * pregnant women * patients with advanced-stage cancer and systemic metastasis
the influence of the 34c>t variant in the ampd1 gene ischemic tolerance

Conditions: AMPD; Ischemic Tolerance

Summary: previous epidemiological studies have shown that in cardiovascular patients, the 34c\>t variant in the gene encoding for the enzyme adenosine mono phosphate deaminase (ampd1) is associated with prolonged survival. the 34 c\>t variant encodes a severely truncated, metabolically inactive protein. we hypothesize that during ischemia, in these patients amp in preferentially converted into adenosine instead of imp. adenosine receptor stimulation, in turn, will increase resistance to ischemia-reperfusion in the myocardial tissue. to test this hypothesis, 7 male healthy volunteers heterozygous for the 34c\>t variant will be selected from 100 healthy volunteers, which we have previously genotyped. these subjects will be compared with 7 matched control subjects. individual ischemic tolerance will be assessed in the thenar muscle using 99mtc-annexin a5 scintigraphy. briefly, the circulation of the nondominant forearm will be interrupted for 10 minutes by inflation of an upperarm cuff to 200mmhg en concomitantly, the subjects will perform isometric rhythmic handgripping until exhaustion. immediately upon reperfusion, 400 mbq of 99mtc-annexin a5 will be administered intravenously. finally, 1 and 4 hours post-injection, scintigrapghi imaging of both hand will be performed. targeting of annexin a5 will be expressed as percentage difference between the experimental and control hand.


Eligibility criteria:
inclusion criteria: * male * 18-40 years * healthy * ampd1 34c\>t variant (heterozygous) or matched control exclusion criteria: * cardiovascular / pulmonary disease * diabetes / hypertension