Kornimate/medical-research-clean huggingface dataset:
do antidepressants induce metabolic syndromes metadap study

Conditions: Major Depressive Disorder

Summary: since antidepressants and antipsychotics have common receptorial mechanisms of action (h1 antagonism, 5ht2 antagonism), the impact of antidepressants in terms of metabolic syndromes is a matter of concern. the main objective of this study is to assess the differential impact of antidepressants in terms of weight gain and metabolic syndromes.

since antidepressants and antipsychotics have common receptorial mechanisms of action (h1 antagonism, 5ht2 antagonism), the impact of antidepressants in terms of metabolic syndromes is a matter of concern. the main objective of this study is to assess the differential impact of antidepressants in terms of weight gain and metabolic syndromes. prospective 6-month naturalistic cohort study, comparing 4 classes of antidepressants (ssris, snris, tcas and others) to a control group (ect and r-tms), in 600 patients with a major depressive disorder requiring the beginning of either antidepressant or ect/r-tms treatment.

Eligibility criteria:
inclusion criteria: * age : 18-70 * current major depressive episode (major depressive disorder) based on the mini interview * ham-d \>18 * requiring either antidepressant treatment, either ect or r-tms (as assessed by the clinician) * signed informed consent exclusion criteria: * bipolar disorder (dsm-iv), psychotic disorder (dsm-iv), substance abuse or dependence (dsm-iv) * normothymic treatment * antipsychotic treatment

Keywords: major depressive disorder antidepressants weight gain metabolic syndromes
the impact of rugae reproduction on complete dentures patients' satisfaction

Conditions: Edentulous Jaw

Summary: the palatal rugae, refer to asymmetrical and irregular elevations of the mucosa located in the anterior third of the palate, on each side of the median palatal raphe and behind the incisive papilla. the lack of the rugae area on the polished areas of the dentures has been suggested to impact phonetics in denture patients. therefore, the aim of this randomized crossover clinical trial was to compare patients' reported satisfaction with their complete dentures and oral health related quality of life, when provided with a denture with a reproduction of their rugae on the anterior palatal area as opposed to a polished palatal surface.

the use of dentures could impact the patients' phonetics which could impact their speech. phonetics could be affected by multiple factors such as having a proper occlusal vertical dimension, proper occlusal plane, correctly positioned anterior and posterior teeth, and adequate contouring of the palatal surface. the lack of the rugae area on the polished areas of the dentures has been also suggested to impact phonetics in denture patients. the palatal rugae, refer to asymmetrical and irregular elevations of the mucosa located in the anterior third of the palate, on each side of the median palatal raphe and behind the incisive papilla. in addition to enhancing phonetics, the precise reproduction of the rugae in the complete dentures has been suggested to enhance mastication, deglutition and better taste perception. however, these suggestions were based on empirical evidence. many studies have described methods for replicating the patients rague on complete dentures, however there are no clinical study to ascertain or negate the impact of this procedure. therefore, the aim of this randomized crossover clinical trial was to compare patients' reported satisfaction with their complete dentures and oral health related quality of life, when provided with a denture with a reproduction of their rugae on the anterior palatal area as opposed to a polished palatal surface. the null hypothesis was that there would be no difference in patients' reported satisfaction rate using visual analogue scale (vas) and oral health impact profile for edentulous patients (ohip-edent) questionnaire response between the two types of palatal contours after using each type for one month post-delivery.

Eligibility criteria:
inclusion criteria: * patients seeking a set of conventional maxillary and mandibular complete dentures at the university of jordan hospital, for the first time or as a replacement of their previous dentures. * patients aged between 45 and 80 years old. * patients had been completely edentulous for at least 3 months * patients without severe underlying medical conditions, neuromascular dysfunction, auditory problems, mental conditions, oral pathology, xerostomia, or tied tongue condition. * patients who approved and consented to participation.
a comparison of adherence rates to ritonavir and its accompanying protease inhibitor

Conditions: HIV Infections

Summary: pharmacologic boosting of protease inhibitors with ritonavir has become standard practice in antiretroviral therapy. patients are instructed to take ritonavir at the same time as its accompanying protease inhibitor. however, ritonavir is unpopular with many patients because of its large size and because of the recommended need for refrigeration. this study will test the hypothesis that adherence to ritonavir is inferior to adherence to its accompanying protease inhibitor in patients receiving such therapy.

the study staff will employ mems caps to prospectively measure adherence to ritonavir and its accompanying protease inhibitor over 24 weeks of follow-up. paired sample t-tests will be employed to compare adherence to the two agents, and secondary analyses will be conducted to evaluate the chronologic concordance of ritonavir and accompanying protease inhibitor dosing.

Eligibility criteria:
inclusion criteria: * hiv infection, age\>18 years, receiving therapy with ritonavir-boosted atazanavir or fosamprenavir, willingness to use mems caps, willingness to provide informed consent exclusion criteria: * treatment with any medication that is contraindicated in combination with ritonavir or its accompanying protease inhibitor

Keywords: hiv, antiretroviral therapy, adherence, ritonavir
evaluation of fontan-associated liver disease

Conditions: Single Ventricle Heart Disease

Summary: a study to evaluate the efficacy of mz101 therapy in reducing liver stiffness.

this is open-label, long-term prospective study in a cohort of fontan subjects taking drug daily for one year. the study will determine the scope of hepatic stiffness in the cohort by ultrasound and magnetic resonance imaging elastography and evaluate mz101 pharmacotherapy as a potentially efficacious treatment to reduce liver stiffness.

Eligibility criteria:
inclusion criteria: 1. enrollment in on-going phase 3 open-label safety study 2. informed assent from subject, informed consent from parent/legal guardian as appropriate exclusion criteria: 1. non-enrollment in the on-going phase 3 open-label study 2. subjects with contra-indications for mri (these subjects will be excluded from the mri component of this study) 3. other exclusionary criteria will match those used for the open-label safety study

Keywords: fontan ultrasound magnetic resonance imaging elastography
availability and advice on test uptake during the covid-19 pandemic: a vignette study.

Conditions: COVID-19

Summary: lateral flow testing (lft) use for covid-19 related symptoms continues to rise, despite governmental advice to test at a test facility. in this study we investigate whether 1) adjusting the governmental testing advice will lead to a collective increase of people who test with covid-19 symptoms and if this leads to a higher strategy sensitivity.

in an online randomised multi-factorial survey (vignette study) participants are randomised to assess four scenario's. between subject testing advise is randomised (iv1; 2 levels) and the availability of lft (iv2; 2 levels). within subject we asked participants to assess their most likely behaviour on day 1 of symptoms and day 3 of unchanged symptoms (iv3; 2 levels). corona-related symptoms are randomly presented (iv4; 4 levels) and new incidences of symptoms are presented in additional vignettes describing new months (iv5; 4 levels). subjects are asked to immerse themselves in the scenario's before answering what their most likely behaviour would be: a) go to a test facility b) use a lft c) wait and see or 4) no test. participants who didn't choose the test facility on day 1 were presented with the same vignette on day 3 with unchanged symptoms, and were asked their most likely behaviour again. after assessing the scenario's, participants fill in a questionnaire assessing demographics, behavioural determinants related to test behaviour, vaccine status, current symptoms and previous experience with corona and testing. the primary outcomes is defined as the average strategy sensitivity over time and therefore the chance of detecting a covid-infection. average strategy sensitivity is calculated by converting the choice of testing behaviour into the corresponding sensitivity score (pcr =1, lft day 1 = .8, lft day 3 = .7, wait and see and no test = 0), averaged over four scenario's. our primary hypothesis is: 1. adjusting the governmental testing advice will lead to a higher strategy sensitivity. in follow-up analysis we will explore the following hypothesis: 2. availability of lft at home will lead to a higher strategy sensitivity. 3. the type of corona related symptoms (mild or severe) are predictive of the type of test used. 4. when confronted with a new incidence of corona-related symptoms over time, strategy sensitivity will decline.

Eligibility criteria:
participants were recruited from an online research panel representative for the dutch population. inclusion criteria: * non exclusion criteria: * non

Keywords: test intentions lateral flow test uptake
a cross-sectional study evaluating pregnancy related use of vitamins and medication

Conditions: Medication and Supplement Use; Pregnant Women

Summary: this cross-sectional study will try to give answers to the following project aims: * to provide an overview of the prevalence of health products' use among belgian pregnant women (prescription and otc medication, vitamin supplements, phyto-therapeutics, dermatologic products), including where pregnant women buy or get their health products (online web survey). * to document women's beliefs about medication during pregnancy and their information desire (online web survey). * to determine the current vitamin status among pregnant women and to reveal clinical targets for supplementing deficiencies in this population (blood sample analysis). the study will be performed at the obstetrics department of the university hospitals of leuven (campus gasthuisberg). we aim to include 300 pregnant women (100 per trimester), of which 150 women will be asked to determine their vitamin status (50 per trimester).


Eligibility criteria:
inclusion criteria: * pregnant women who visit the obstetrics department of the university hospitals of leuven * ≥18 years * able to understand dutch, french or english exclusion criteria: * \<18 years * don't able to understand dutch, french or english

Keywords: medication beliefs information desire vitamin deficiencies
effect of exercise on cognitive function and mental health in heroin addicts

Conditions: Unspecified Symptoms and Signs Involving Cognitive Functions Following Unspecified Cerebrovascular Disease; Heroin Addicts; Executive Function; Negative Thinking/Affect

Summary: the goal of this \[type of study: exercise intervention study\] is to test in describe participant health conditions. the main questions it aims to answer are: * \[whether physical exercise improves executive function of male heroin addicts\] * \[whether physical exercise improves negative thinking/affect psychological experience of male heroin addicts\] participants will be randomly selected for medium-intensity strength training (resistance exercise,n=30), 30 will be selected for 1-hour long balloon volleyball sessions (aerobic exercise) at 60-70% volume of oxygen uptake during peak exercise, weekly 5 times for 12 weeks; and 30 will be assigned to the no-exercise control group, participants will perform executive function tests and the symptom checklist-90 revised questionnaire at pre and post intervention. researchers will compare resistance exercise group,aerobic exercise group and no-exercise control group to see if effects of exercise on executive function and negative thinking/affect psychological experience of male heroin addicts.


Eligibility criteria:
inclusion criteria: * were men who met the manual of mental disorders (dsm)-iv criteria for current heroin dependence exclusion criteria: * any major mental illness other than heroin addiction * any exercise taboo
a survey of parent/caregiver practices on the storage, use, and disposal of opioids in a comprehensive cancer center

Conditions: Caregiver; Malignant Neoplasm

Summary: this trial uses a survey to study parent and caregiver practices on the storage, use, and disposal of opioids in a comprehensive cancer center. it is not known if parents and/or caregivers are aware of the guidelines and recommendations for proper and safe disposal of opioids. this survey will help health care providers assess the needs and improve the safety of patients and their families from the potential dangers of misuse and abuse of prescription opioid medications.

primary objectives: i. to determine the frequency of unsafe storage, use, and disposal of unused and currently used opioids by parents and/or caregivers of patients 18 years and younger at md anderson cancer center. ii. to explore potential association between other covariates with the unsafe storage, use, and disposal of opioids. outline: participants complete online survey on an ipad over 20 minutes.

Eligibility criteria:
inclusion criteria: * parents/caregivers: must be at least 18 years old (a. the child of the parents/caregivers must be 18 years old or younger; b. the child of the parents/caregivers must have received an opioid prescription within the last six months.) * parents/caregivers: must be able to understand, read, write, and speak english. * parents/caregivers: parent/caregiver must sign an informed consent.
long-term examination of titanium dental implants with a tps surface: a prospective 20-year case series study

Conditions: Dental Implants; Periimplantitis

Summary: since 1986, newly developed titanium implants with a tps surface have been utilized for the treatment of partially edentulous patients with implant supported fixed dental prostheses (ftp). in the beginning, these implant types have been sold by straumann under the brand name "bonefit implants", later "iti dental implant system" from the beginning, the first 75 patients have been documented in a prospective case series study, and clinical and radiographic results have been reported at 1-year, 3-years, 5-years and 8-years. the aim of the present study is to examine the long-term outcomes of this original group of patients with at 20 years of clinical function, and to assess the frequency of biological and technical complications during this follow-up period.

background: the rehabilitation with implant-supported restorations has been a successful treatment modality in fully and partially edentulous patients since the early 1980s . today, partially edentulous individuals have become the main group of patients being considered for implant therapy, and several reports have been published showing favorable long-term outcomes with different dental implant systems. in systematic reviews analyzing the long-term performance of osseointegrated implants, clinical studies with 5-year observation periods are frequently included. however, studies with a 10-year observation period are sparse. only three clinical studies with an observation period of 20-years in edentulous or partially edentulous patients have been found. objective: the objective is to evaluate dental implants after 20 years of function. methods: partially edentulous patients provided with implants between 1986 and 1989 at the department of oral surgery and stomatology at the university of bern recruited for a clinical and radiographic evaluation 20 years after implant installation. a total of 75 patients with 102 implants will be recalled for a clinical and radiographic examination. all implants installed were hollow screw and hollow cylinder implants (straumann, waldenburg, switzerland) with a rough tps surface. they were placed according to the manufacturer's guidelines. the superstructures consistent in single crowns or fixed partial dentures, which were incorporated 4-6 months postsurgically. all patients will be evaluated using information from patient's charts and from the 20-year examination. apical radiographs will be taken from the implant and the adjacent tooth. the marginal bone level around the adjacent tooth will also be calculated using the implant shoulder a reference point.

Eligibility criteria:
inclusion criteria: * original group of patient exclusion criteria: * other patient than from original group

Keywords: survival rate success rate
efficacy and safety study of udenafil tablets in erectile dysfunction.

Conditions: Erectile Dysfunction

Summary: this randomized, double blind, placebo controlled, multicentric, clinical study will assess the efficacy and safety of udenafil (100 mg) tablets in patients suffering from erectile dysfunction(ed).


Eligibility criteria:
inclusion criteria: * male patients of 18 to 60 years of age. * patients in a stable, monogamous sexual relationship with a female partner for at least 6 months and willing to maintain this relationship for the duration of the study. * patients with established diagnosis of erectile dysfunction (ed) of organic, psychogenic or mixed etiology for at least 6 months duration. * patient willing to attempt at least one sexual intercourse in a week for the entire treatment. exclusion criteria: * patients with total erectile failure or any other sexual disorder such as hypoactive sexual desire. * patients who have previously failed to respond to pde-5 inhibitors like sildenafil, vardenafil or tadalafil. * patients who have used other erectile dysfunction therapies within 14 days (2 weeks) prior to entering into this study (i.e. visit 1). * patients with hypogonadism or anatomical deformity of the penis such as severe penile fibrosis or peyronie's disease or penile trauma. * patients with a history of major psychiatric disorder. * patients with a history of significant pathological cardiovascular conditions such as: congestive heart failure, life-threatening arrhythmia or ischemic heart disease within the past 6 months. * patients with a history of central nervous system disorders such as stroke, transient ischemic attacks or spinal cord injury or a radical prostatectomy or radical pelvic surgery. * patients with hypotension (\ 170/100), uncontrolled diabetes, hepatic impairment (sgot or sgpt levels \> 3 x upper normal limit), renal impairment (serum creatinine \> 2.5mg/dl), hematological disorders such as bleeding disorders. * patients with a history of retinitis pigmentosa, proliferative diabetic retinopathy or non-arteritic anterior ischemic optic neuropathy (naion). * patients with a history of sickle cell disease, multiple myeloma, leukemia or any other disorders that may cause priapism. * patients on concomitant treatment with nitrates/nitrites(no) donor, cyp3a4 inhibitors, cyp3a4 inducers, anticoagulants, androgens, antiandrogens or trazodone. * patients with known hypersensitivity to pde 5 inhibitors like sildenafil, vardenafil or tadalafil. * patient with known diagnosis to aids or with a positive hiv result at study screening visit. * patients with any other serious concurrent illness or malignancy. * patients with continuing history of alcohol and / or drug abuse. * participation in another clinical trial in the past 30days.
advancing prevention of pulmonary fibrosis

Conditions: IPF; Pulmonary Fibrosis; ILD

Summary: this study plans to learn more about pulmonary fibrosis and how it develops. we want to determine if the disease can be detected early, before the lung is permanently scarred. this study will enroll participants who are not currently diagnosed with pulmonary fibrosis, but who have family members with pulmonary fibrosis. because there is an increased risk within affected families, this cohort will allow us to learn how pulmonary fibrosis develops, and how the lungs change over time.


Eligibility criteria:
inclusion criteria: * unaffected first degree relative from familial interstitial pneumonia families (two or more family members with iip) * age at least 40 years old and younger than 75 years old exclusion criteria: * diagnosed with known (physician-diagnosed) pulmonary fibrosis prior to informed consent * other genetic diseases associated with interstitial lung disease * pregnant women
decreasing dialysis cardiovascular risk: daily versus longer treatments

Conditions: Cardiovascular Disease

Summary: given the known increased risk of heart disease in hemodialysis patients, this study aims to evaluate the change in both size and function of the heart by using cardiac magnetic resonance imaging (mri) in patients undergoing either daily long (4 hours, 6 times weekly), daily short (2 hours 6 times weekly), or alternate day conventional (4 hours, 3 times weekly) and alternate day long (8 hours, 3 times weekly) dialysis for 6 months from randomization. the patients are randomly put in the groups based on predetermined randomization schedule and the cardiologist trained in cardiac mri readings is blinded to the patient treatment schedule. given that changes in heart function may be seen with cardiac imaging techniques within 6 months, the expectation is that groups on daily treatment may have better outcome for this parameter as changes in volume and blood pressure may also be affected in a positive way in patients on daily dialysis.


Eligibility criteria:
inclusion criteria: * end stage renal disease patients on hemodialysis exclusion criteria: * weight \> 350 lbs * known poor dialysis and or treatment compliance * unable to come for daily treatments if randomization occurs in this group * prognosis less than 6 months * difficulty in tolerating dialysis and possibility of discontinuation of dialysis before 6 months

Keywords: left ventricular mass cardiac mri long dialysis daily dialysis