Kornimate/medical-research-clean huggingface dataset:
determination of the effects of change in anxiety level on pain perception in patients who present to emergency department

Conditions: Pain, Acute; Anxiety

Summary: the aim of this study is to determine the level of pain and anxiety in patients who present to the emergency department with acute pain, and to investigate the effect of the standard analgesic treatment and an additional anxiolytic treatment on pain and anxiety.

after triage, each acute pain patient who qualified for the study was asked for consent. written informed consent was obtained from all patients who were eligible for the study. after obtaining written informed consent, demographic and clinical data were collected and recorded by the attending physician. our study consisted of two parallel groups. participants were randomly assigned into two groups with a 1:1 allocation following simple randomization procedures by a program generating an online random number. the control group was given only the analgesic drug dexketoprofen trometamol and the study group was given analgesic plus anxiolytic, the same dose of dexketoprofen trometamol plus midazolam . both groups received the study drugs in 100 ml of normal saline within 5 minutes. the dexketoprofen trometamol dose was 50 mg, and the midazolam dose was 1 mg. the study was double-blind. sequenced study medications were prepared by a nurse, and another nurse administered the medications. in patients with an insufficient improvement of pain after 60 minutes, fentanyl 1 mcg/kg ı.v. was administered as a rescue medication. pain and anxiety in patients was measured at 0, 30, 60 and 120 minutes using the standard 100 mm horizontal visual analogue scale (vas). the patient's general anxiety states were measured with the turkish adopted version of the hospital anxiety and depression scale (hads). patients who have greater than 10 points are assumed anxious (9). the hads and vas scores were measured and recorded to the database by the researcher. at the time of discharge, patient satisfaction with treatment was evaluated by asking two questions with the 5-step likert scale. the questions were, "i am satisfied with the applied treatment", and "i would like the same treatment applied again". patient answers were, "1-i strongly disagree", "2-i disagree", "3-i am not sure", "4-i agree", and "5-i strongly agree".

Eligibility criteria:
inclusion criteria: * the patients who presented to the emergency department with acute pain * who accepted to include the study * who were older than 18 years old exclusion criteria: * patients who refused to participate to the study * history of allergy to any of the study drugs * pregnancy * younger than 18 years old * chronic pain * antidepressant or anxiolytic drug use * advanced kidney or liver failure * use of analgesics within 6 hours before presentation

Keywords: pain anxiety emergency department pain management
late neutropenia in vlbw preterm babies

Conditions: Neutropenia

Summary: there are rare reports regarding late neutropenua in very low birth weight preterm infants. the investigators wish to characterize it among our population, and assess its consequenses and the postnatal menagement of the infants.

there are rare reports regarding late neutropenua in very low birth weight preterm infants. the investigators wish to characterize it among our population, and assess its consequenses and the postnatal menagement of the infants.

Eligibility criteria:
inclusion criteria: * preterm infant with birth weight up to 1500 gram exclusion criteria: * early neutroenia - neutrophil count \< 1500 at the first week

Keywords: vlbw neutropenia
a study of car-t cells targeting autoimmune diseases

Conditions: Autoimmune Diseases

Summary: the purpose of this study is to assess the safety and efficacy of car-t cell therapy in patients with autoimmune disease.

autoimmune disease refers to the disease in which the immune system reacts to the host's own body and causes damage to tissues and organs. autoreactive b cells can self-activate and differentiate into plasma cells releasing large amounts of autoantibodies, while they can also present their own antigens to autoimmune t cells, thus activating t cells and promoting the release of inflammatory factors. car-t cells can theoretically completely deplete abnormal antibody-producing b cells, allowing immune rebuilding and restoring the patient's normal immune function, achieving drug-free survival, which fully reflects the application prospects of car-t therapy in autoimmune disease.

Eligibility criteria:
inclusion criteria: 1. male or female, between 18 and 56 years old; 2. diagnosed with autoimmune diseases； 3. good organ functions; 4. voluntary participates this trial and can comprehend and sign icf. exclusion criteria: 1. had or has active malignancy; 2. had been subjected to treatment by cd19 targeted therapy or car-t therapy or any gene therapy; 3. combined with other autoimmune disease that needs treatment; 4. pregnant or lactating women; 5. has other factors that deemed not suitable by investigator.
hyponatremia and myometrium contractility. an invitro study

Conditions: Hyponatremia

Summary: hyponatremia during labour has been associated with prolonged labour, and increased incidence of instrumental delivery and emergency caesarean section. sodium influx in myometral cells are involved in contractility,and and influence of hyponatraemia on contractility can be suspected.

biopsies will be obtained from pregnant women undergoing planned caesarean section at term. the biopsies will divided into 3 strips that will be stored overnight in chilled nacl 0.9%. the following morning each strip will be mounted isometrically with one end fixed to a holder and the other end to a force transducer. one strip will be maintained in a solution containing 140mmol/l na,acting as control, whereas the other two strips will be placed in fluids with diminishing na concentration, from 140 mmol/l, to 130 mmol/l and 120 mmol/l. contractility will be measured with force transducers and a polygraph

Eligibility criteria:
inclusion criteria: * singleton pregnancy at term exclusion criteria: * preeclampsia

Keywords: contractility human myometrium hyponatraemia
changes in invitro and ex vivo lens metrology with daily wear contact lenses

Conditions: Myopia

Summary: the purpose of this study is to evaluate changes in contact lens geometry after lens wear

the purpose of this study is to evaluate changes invitro and ex vivo in contact lens geometry in daily lens wear

Eligibility criteria:
inclusion criteria: * • able to read and comprehend english and give informed consent as demonstrated by signing a record of informed consent; * be at least 18 years old; * willing to comply with the wearing and clinical trial visit schedule as directed by the investigator; * have ocular health findings considered to be "normal" and which would not prevent the participant from safely wearing contact lenses; * has vision correctable to at least 6/12 (20/40) or better at distance in each eye with contact lenses; * be experienced at wearing contact lenses. exclusion criteria: * • any pre-existing ocular irritation, injury or condition (including keratoconus and herpes keratitis) of the cornea, conjunctiva or eyelids that would preclude contact lens fitting and safe wearing of contact lenses; * any systemic disease that adversely affects ocular health * an active corneal infection or any active ocular disease that would affect wearing of contact lenses; * use of any topical ocular medication during trial with the exception of saline drops ; * use of or a need for any systemic medication or topical medications which may alter normal ocular findings/are known to affect a participant's ocular health/physiology or contact lens performance * eye surgery within 12 weeks immediately prior to enrolment for this trial; * previous corneal refractive surgery; * contraindications to contact lens wear; * participated or currently enrolled in another clinical trial that may have affected vision or ocular physiology within the previous 2 weeks; * be pregnant (formal testing of pregnancy is not required. a participant's verbal report is sufficient); * worn soft contact lenses 2 calendar days or rigid gas permeable/ orthokeratology lenses 7 calendar days prior.

Keywords: contact lenses, myopia, lens geometry
pilot study of the effect of purple rice on glucose tolerance, serum lipids and inflammation

Conditions: Type 2 Diabetic

Summary: this is a pilot study to demonstrate the effect of purple rice on post-prandial glucose and insulin. the purple color is due, like red wine grapes, mainly to the anthocyanins. the safety and tolerability of purple rice is similar to white or brown rice, but contains the purple elements common to other foods like grapes.

this is a study that will have 1 screening visit and 9 study visits. subjects will come to the screening visit for blood chemistry, health questionnaire and speak to the coordinator. each subject passing inclusion/exclusion will go on to eat purple rice for 4 weeks and brown rice for 4 weeks. the 4-week feeding periods will be balanced and assigned randomly. the subjects will report to the metabolic kitchen to pick up their supply of 14 frozen rice dishes each week in a container and return the empty containers as a measure of compliance. at the end of each 4-week feeding period, subjects will come to the inpatient unit fasting from 9pm the prior night except for water. subjects will have an intravenous line placed and fasting blood will be drawn for chemistry. subjects will then be given glucose to drink and blood will be drawn from then iv line for glucose and insulin at time listed in the consent.

Eligibility criteria:
inclusion criteria: * generally healthy male or female with a fasting glucose between 100 mg/ml and 126 mg/dl or with type 2 diabetes controlled on diet without diabetes medications. * eighteen years of age or older. * hemoglobin a1c(hgba1c) less than 7%. exclusion criteria: * pregnant or nursing. * taking a medication for diabetes (e.g. metformin), a medication known to affect blood sugar (e.g. glucocorticoids), an anti-inflammatory medication (e.g. aspiring) or triglycerides (e.g. fibrates). * any chronic medication that has not had a stable dose for 1 month or longer.
urethral length and tot (transobturator tape) positioning

Conditions: Stress Urinary Incontinence

Summary: this is a prospective, observational, multicenter study of women with surgically-correctable stress urinary incontinence who undergo a tot-sling operative procedure.

this is a prospective, observational, multicenter study of women with surgically-correctable stress urinary incontinence who undergo a tot-sling operative procedure. data will be collected from preoperative urogynecological testing and medical histories. outcome data will be collected 1-3 days and 6 months after procedure.

Eligibility criteria:
inclusion criteria: 1. patient has objective demonstrable signs of stress urinary incontinence (sui), including patients with intrinsic sphincter deficiency (isd). objective testing includes: standing stress test, urodynamics evaluation, or pad test. 2. patient is age 18 or older. 3. patient agrees to participate in the study, including completion of all study-related procedures and evaluations, and documents this agreement by signing the institutional review board (irb)/ethic commission (ec)-approved informed consent. 4. patient is able to fill in all questionnaires (on judgement of investigator) exclusion criteria: 1. patient has an associated or suspected neurological disease. 2. patient has an active lesion or present injury to perineum or urethra. 3. patient has a urethral obstruction. 4. patient has significant pelvic organ prolapse (grade iii/iv) requiring surgical treatment. 5. patient currently has an urinary tract infection.

Keywords: stress urinary incontinence transobturator sling tot
hcv evolution in hiv/hcv (genotype 1) coinfected patients treated with fosamprenavir

Conditions: Chronic HIV Infection; HCV Coinfection

Summary: this study examines the impact of fosamprenavir as part of an art on virological, immunological and clinical parameters of genotype 1 hcv infection in hiv co-infected subjects. fosamprenavir could have a direct or immune-mediated activity against hcv. if this is shown to be true, changes in hcv viral load or biological characteristics could be demonstrated.


Eligibility criteria:
inclusion criteria: * age \>18 yo * hiv/hcv co-infected patients with hcv detectable viremia in 2 determinations separated at least by 6 months. * hcv genotype 1 * currently receiving art including 2nrti+1 pi/r (excluding fpv) or 1 nnrti, without changes in the last 6 months * hiv rna \< 50 copies/ml for the last 6 months exclusion criteria: * previous anti hcv treatment * foreseeable hcv treatment in the next 12 months * acute hcv infection * active opportunistic infection * hiv with fpv resistance mutations * current or previous treatment with fpv * chronic hepatitis b * current alcohol consumption greater than 20 g per day

Keywords: hiv hcv hiv/hcv coinfection fosamprenavir
validation of the tmd pain screener in a specialized headache center

Conditions: Temporomandibular Disorder; Headache Disorders

Summary: the purpose of the study is to investigate whether a questionnaire can be used to detect whether patients referred to the danish headache center have a painful temporomandibular disorder (tmd). tmd is a major public health problem that affects up to 15% of the adult population and can cause headaches that can be immediately difficult to differentiate from other headache types such as tension headaches and migraines. by applying the so-called diagnostic criteria for tmd through a standardized study program, tmd diseases such as myalgia of the jaw muscles, arthralgia and discus displacements of the jaw joints and jaw arthritis can be diagnosed. however, this requires dental expertise and is time consuming. at the danish headache center, the current screening question is used for tmd in order to identify who could benefit from further investigation in dentistry. but it is still unknown how accurate these questions are in selecting those patients who have tmd diseases in a patient group with a headache. the investigators would like to investigate this in order to improve the referral procedure of headache patients for relevant dental treatment or physiotherapy. this is believed to be of importance both in a specialized unit such as the danish headache center and in neurological medical practice. patients will be recruited who are referred to the danish headache center, who have been given tmd screening questions and who have indicated in writing that they wish to be contacted for research projects. in the study, 25 subjects with tmd screening question score of ≥ 3 points will be included, which will be gender and age matched with 25 subjects who have tmd screening question score of \<3 points. the patients will be interviewed to classify the patients headache 15 min and then have a jaw examination done and then the dc / tmd examination will be done and lasts approx. 30 min. the examination is performed by a skilled physiotherapist and it does not involve any side effects or risks.


Eligibility criteria:
inclusion criteria: * men and women between the ages of 18 and 75 who are referred to the danish headache center exclusion criteria: * no known pre-existing significant tmd or dental disease that can cause headaches * anamnestic or clinical signs of a condition of any kind that is considered relevant by the investigating physician for participation in the study. * patients who do not wish to be informed of the findings of presence of tmd

Keywords: orofacial pain dc/tmd
furosemide stress test for the prediction of acute kidney injury severity in acute heart failure patients

Conditions: Heart Failure; Acute Kidney Injury

Summary: this study is aim to study the changes of serum creatinine levels at 72 hours after admission in patients with acute heart failure who has diuretic resistance compared to those who do not have diuretic resistance from furosemide stress test

this study is an observational prospective study to demonstrate a prognosis of acute heart failure patients who have diuretic resistance compared to those who do not have diuretic resistance from furosemide stress test. the primary outcome is changes of serum creatinine levels at 72 hours compared to baseline values at the time of admission.

Eligibility criteria:
inclusion criteria: * age ≥18 years * diagnosis of acute heart failure which is defined by 2 of the 3 following features: ≥2+ leg edema, jugular venous pressure \>10 cm from physical examination or central venous pressure \>10 mmhg, and bilateral pulmonary edema or bilateral pleural effusion from chest radiography * patients consent to participate into the study exclusion criteria: * patients who receive furosemide ≥500 mg/day or hydrochlorothiazide ≥100 mg/day or spironolactone ≥100 mg/day or tolvaptan of any doses * patients who have systolic blood pressure \<100 mmhg or who need vasoactive drugs inotropic agents (except dobutamine) * patients with intravascular volume depletion from clinical evaluation * patients with chronic kidney disease stage 5 (estimated glomerular filtration rate \<15 ml/min/1.73 m2) or patients who receive maintenance dialysis * patients who require renal replacement therapy at the time of admission * patients whom diagnosed hypertrophic obstructive cardiomyopathy, severe valvular stenosis or complex congenital heart disease * patients with sepsis or systemic infection * pregnant women * patients who have history of furosemide, spironolactone or hydrochlorothiazide allergy
determinants of glycaemic control in children with type 1 diabetes

Conditions: Diabetes Mellitus, Type 1

Summary: type 1 diabetes (t1d) is a common chronic disease of childhood associated with a significantly increased risk of micro- and macro-vascular complications, including neuropathy, nephropathy and cardiovascular diseases. the risk of development t1d comorbidities is associated with glycaemic control, a complex mechanism involving biological, physiological environmental factors. while more than 60 genetic variants were already associated with glycated hemoglobin (hba1c) in healthy subjects, very few genes have been identified in t1d individuals. also, hyperglycaemia could be the cause of epigenetic changes at specific target genes, such as dna methylation, histone modifications and micrornas, correlated to accelerated development of diabetes-related complications. most recently, increasing evidence also suggested that human microbiome may play a crucial role in the onset and progression of t1d and dysbiosis of the gut and oral microbiota was reported as a typical feature of hyperglycaemia. however, potential differences among poorly and good managed t1d subjects have not been still studied. also, the exact mechanism by long-term hyperglycaemia's acts in t1d remains poorly understood. therefore, this project will explore an emerging area of research by the study of possible genetic, epigenetic and environmental biomarkers among t1d subjects with different glycaemic control.


Eligibility criteria:
inclusion criteria: * type 1 diabetes subjects * age from 6 to 20 years old * at least 5 years of duration of disease exclusion criteria: * type 1 diabetes subjects incapable of giving valid informed consent or whose parents are incapable of giving valid informed consent. * type 1 diabetes subjects for whom it is not possible to collect information on the clinical history, starting from the onset of diabetes * subjects with other types of diabetes (i.e. type 2, monogenic diabetes, cystic fibrosis related diabetes)

Keywords: type 1 diabetes glycaemic control epigenetic modifications diabetes-related complications
reducing teen pregnancy in the emergency department

Conditions: Reproductive Behavior; Sexual Behavior; Adolescent Behavior; Contraception

Summary: this study will determine the feasibility, acceptability, and potential efficacy of an emergency department-based pregnancy prevention intervention targeting sexually active adolescent female emergency department patients.

emergency departments (ed) care for 15 million adolescents each year. adolescents who use the ed are at particularly high risk of unintended pregnancy. to date, no intervention has successfully increased contraception use among this high risk, hard-to-reach ed population. in this study, the investigators will conduct a pilot randomized controlled trial of a user-informed, theory-based, personalized, interactive, pregnancy prevention text messaging intervention (dr. erica) to determine its feasibility, acceptability and potential efficacy. the investigators hypothesize that high risk adolescent female ed patients who receive dr. erica will more often initiate contraceptives than those females who receive standard discharge instructions alone. at baseline and follow-up assessment at 3 months, participants will provide information regarding effective contraception initiation, any contraception at last intercourse, follow up with reproductive preventive health services, and contraception self-efficacy.

Eligibility criteria:
inclusion criteria: * female emergency department patient * age 14-19 years * sexually active with males in the past 3 months exclusion criteria: * currently using any effective form of contraception * do not own a mobile phone with texting * are pregnant * are too ill for participation per the attending physician * are cognitively impaired * do not live locally * do not speak english * want to "become pregnant in the next year"

Keywords: emergency medicine reproductive health sexual health adolescent health emergency department text messaging mobile health digital health
omega 3 fa supplements as augmentation in the treatment of depression

Conditions: Major Depression; Cancer; Diabetes; Cardiovascular Diseases

Summary: to assess the efficacy of omega 3 fatty acid (omega 3 fa) augmentation of desvenlafaxine (dvs) compared to placebo augmentation of dvs when used to treat depression and anxiety symptoms in patients with select medical conditions (cancer, cardiovascular diseases and diabetes).


Eligibility criteria:
inclusion criteria: * 18 years of age or older * diagnosed with depression and have cardiovascular disease, diabetes or cancer. * able to provide written informed consent prior to initiation of any study-related procedures. * able to understand and comply with the requirements of the study. exclusion criteria: * hospitalized patients or psychotherapy for depression begun within 4 weeks. * patients with medically reversible causes of depression (e.g. hypothyroidism). * patients with significant comorbid symptoms (e.g. pain, insomnia) that have a direct causal relation to depressive and anxiety symptoms with these comorbid symptoms dominating the clinical scenario. patients will be enrolled in the study if these comorbid symptoms merely coexist with depressive and anxiety symptoms and are not dominating the clinical scenario as judged by the study investigator * patients with an identifiable diagnosis of substance abuse or dependence within 6 months prior to evaluation (except those in full remission, or those with caffeine or nicotine dependence) as defined by dsm-iv criteria. * patients with any clinically significant unstable or inadequately treated co-morbid medical condition which, in the opinion of the investigator, would make the patient unsuited for the study * patients with currently active or with significant history of other clinically significant psychiatric disorders such as bipolar disorder, schizophrenia etc. * pregnant patients, breastfeeding or those planning to become pregnant during the study. * any other condition, which, in the opinion of the investigator, would make the patient, unsuited for enrollment in the study, including known or suspect history of allergy to fish oil, fish or desvenlafaxine.

Keywords: omega 3 fatty acid fish oil depression cancer diabetes high blood pressure cardiovascular