Kornimate/medical-research-clean huggingface dataset:
addressing anxiety and stress for healthier eating in teens

Conditions: Obesity; Overweight; Anxiety; Mental Disorders; Body Weight; Eating Behavior; Feeding and Eating Disorders

Summary: project asset will explore the preliminary efficacy of interpersonal therapy, when compared with cognitive behavioral therapy, for reducing anxiety symptoms, preventing excess weight gain, and reducing cardio-metabolic risk in adolescent girls with above-average weight and elevated anxiety. as a pilot for a larger multi-site study, this trial will also test multi-site feasibility, acceptability, and intervention fidelity.

this study is a randomized controlled trial in which 40 adolescent girls aged 12-17 years-old with weight in the 75th percentile or higher for their age and sex, and elevated anxiety symptoms, will be randomly assigned to an ipt or cbt 12-week group intervention. approximately 20 adolescent girls will be enrolled at each of two sites: uniformed services university (usu) and colorado state university (csu). after a screening and baseline assessment, participants will attend an individual meeting with the leaders of their assigned group to learn more about the group process and establish goals. they will then participate in the group program for 12 consecutive weeks. each group will be led by a phd-level clinical psychologist and a healthcare trainee. in-person and remote assessments, will be conducted at baseline, in the \~two weeks post-intervention (i.e., 12-week follow-up), and at 1, 2, and 3 years post-intervention. these assessments will consist of body measurements, blood draws for collection markers of metabolic functioning, and surveys and interviews of psychological and social functioning. at baseline, two weeks, and one year post-intervention, participants will also have a week-long period during which they will wear devices collecting activity and physiological data, and complete phone surveys assessing disinhibited eating behaviors, food craving, affect, cognitions, and avoidance behaviors.

Eligibility criteria:
participant inclusion criteria: * 12-17-year-old adolescent girls * bmi ≥ 75th percentile * anxiety symptoms: 32 or higher on state trait anxiety inventory for children-trait scale participant exclusion criteria: * any medical condition (as well as pregnancy or breastfeeding) * individuals who have any dsm psychiatric disorder that, in the opinion of the investigators, would impede competence or compliance or possibly hinder completion of the study * medication impacting mood or weight * psychotherapy

Keywords: obesity overweight anxiety adolescent prevention interpersonal psychotherapy cognitive behavioral therapy
water drinking test in patients with occludable angle

Conditions: Glaucoma

Summary: the water drinking test (wdt), is a predictive test that has been used to detect primary open angle glaucoma and recently has been demonstrated as a predictor of the diurnal tension curve. clinically accurate provocative tests for asymptomatic eyes with shallow anterior chambers and narrow angles are highly desirable to detect patients prone to angle closure glaucoma. the aim of this pilot study is to evaluate the possible role of water drinking test in patients with narrow angles who are scheduled for prophylactic laser iridotomy.

this prospective case series will investigate the effects of the wdt on subjects with narrow anterior chamber angles on the day of their scheduled laser iridotomy. the angle configuration and iop will be monitored following the wdt. twenty patients with occludable angles will be enrolled in this study. after measuring the baseline iop, weight and height, the patients will be asked to drink 10ml/kg water over 15 minutes (equal to approximately 0.33 ounces of water for every 2.2 pounds of weight or 2 ½ cups for a 150 lb. individual) and their iop will be checked every 15 minutes up to one hour after drinking the water. this will be repeated after performing a laser iridotomy. the data obtained, mainly iop and gonioscopic findings, will be analyzed using statistical tests and compared to historical controls of the wdt without narrow angles, and laser iridotomy subjects without the wdt.

Eligibility criteria:
inclusion criteria: * narrow angle judged to be at risk of attack by the treating physician, with one or more quadrants not open to the sclera spur on gonioscopy * age between 21 and 90 years * ability to give informed consent. exclusion criteria: * baseline iop higher than 21 mm hg with or without medication * other causes of glaucoma, such as pseudoexfoliative and pigmentary glaucomas * previous treatment with argon laser or selective laser trabeculoplasty * previous refractive sugary; (5) pregnant women; (6) congestive heart failure * renal failure or urinary retention issues; (8) corneal abnormalities preventing reliable iop measurement * non-glaucomatous optic neuropathy * prior refractive surgery or other issues preventing accurate goldmann applanation tonometry * prior intraocular surgery
comparison of the use of vac system in transplants of leg ulcers versus usual dressing method

Conditions: Leg Ulcer

Summary: to evaluate the vac (vacuum assisted closure) therapy in transplants of leg ulcers versus usual dressing method. the vac therapy system consists of: * a unit delivering a precise under atmospheric pressure, controlled and regulated in the wound site, * consumables necessary for the implementation of the dressing, * collecting tanks exudates with gel. vac therapy is a system using negative pressure. it is known to be efficient into care of chronic wounds and ulcerous wounds by increasing the cicatrisation. this system is systematically used into the dermatology unit of the chu of saint-etienne after transplants of leg ulcers, but no data confirms the interest of this method compared to usual dressing method. this study will provide this data.


Eligibility criteria:
inclusion criteria: * patient hospitalized into the dermatology unit * patient with an evolutive leg ulcer since more than 1 month * signed informed consent exclusion criteria: * known allergy to one of dressings used in this study * patient with a non-treated osteomyelitis * patient with tumoral tissues into the wound * patient with raw organ or raw blood vessels * patient with an anticoagulation treatment with a potentially hemorrhagic curative dose * patient having hemostasis problems that can lead to hemorrhagic exudates

Keywords: vacuum assisted closure
vac and conventional dressing in the healing process of necrotizing fasciitis

Conditions: Necrotizing Fascitis

Summary: find out the best management of necrotizing fasciitis after surgical debridement

necrotizing fasciitis is a life-threatening condition that can occur as a result of trauma or foreign bodies in surgical wounds as well as idiopathically. necrotizing fasciitis is characterized by a progressive infection in fascial planes with necrosis of the subcutaneous tissue. necrotizing fasciitis affects the extremities more frequently than central areas. risk factors for necrotizing fasciitis include diabetes mellitus, trauma wound infections, decubitus ulcers, alcoholism, carcinoma, peripheral vascular disease, smoking, and intravenous drug abuse. a varieties of micro-organisms, including gram-positive group a streptococcus, haemolytic streptococci, and staphylococcus aureus; gram-negative enterobacteriaceae, escherichia coli, klebsiella spp., and proteus spp.; anaerobes including peptostreptococcus, clostridium, and pacteroides; and fungi such as candida and acid-fast bacteria have all been implicated in the pathogenesis of necrotizing fasciitis. necrotizing fasciitis is a surgical emergency for detoxification by debridement with good antibiotic coverage. it has mortality rate reaching 20-30% , this mortality rate is high and requires prompt diagnosis, antibiotic treatment and extensive necrosectomy up to intensive care units admission in some cases, the aim of our prospective analysis is to assess with a hypothesis-generating and exploratory purpose the possible role of vac versus ordinary dressings in the wound therapy of necrotizing fasciitis in terms of expected time for wound closure and survival rate.

Eligibility criteria:
inclusion criteria: * immunocompromised patients such as; diabetic, hiv and leukaemia. and other chronic debilitating diseases. exclusion criteria: * necrotizing fasciitis of head and neck and upper limbs.
r&d study to evaluate cordio's usability and to collect patient speech utterances

Conditions: Chronic Heart Failure

Summary: to determine the usability and technical aspects of cordio hearo™

the system (including app and server) will be tested under simulated use conditions with representative users to identify potential changes required to the application user interface, to improve user performance and satisfaction, and to inform future design options. the recordings data will also be used for algorithm improvement

Eligibility criteria:
major inclusion criteria: 1. adults patients 2. diagnosed with symptomatic chronic heart failure \[nyha ii-iva (ambulatory)\] 3. at least one of the following: 1. one adhf hospitalization in the last 12 months 2. one unplanned iv/sc diuretic administration in the last 6 months 3. two unplanned iv/sc diuretic administration in the last 12 months 4. ntprobnp \>500 pg/ml or bnp\*\> 150 pg/ml at screening visit 4. clinically stable hf 5. willing to participate as evidenced by signing the written informed consent. 6. male or non-pregnant female patient (pre-menopausal women will confirm verbally). major exclusion criteria: 1. not able to read in hebrew, russian, arabic, english and/or spanish. 2. unable to comply with daily use of the app 3. major cardiovascular event 4. had a cardiac resynchronization device (crt) implanted or upgrading ≤ 1 month prior to screening visit. 5. has estimated glomerular filtration rate (egfr) \< 30 ml/min/1.73 meter square (cockroft-gault formula). 6. is likely to undergo heart transplantation/ lvad within 6 months of screening visit.

Keywords: chf
psychological impact of quarantine in osteoporosis patient during covid-19 outbreak

Conditions: Sars-CoV2; Osteoporosis

Summary: in the context of quarantine with covid-19, we wish to study the experience and psychological impact in adult patients living with osteoporosis.


Eligibility criteria:
inclusion criteria: * patient with osteoporosis * patient in confinement * patient with sufficient understanding of the french language exclusion criteria: * non adult patient * patient without quarantine

Keywords: psychological impact covid-19
primary graft dysfunction, pronation, bilateral lung transplants

Conditions: Lung Transplant; Primary Graft Dysfunction

Summary: proning manoeuvre as an early treatment for acute severe hypoxic respiratory failure has been implemented recently during the covid-19 pandemic. this method was proposed more than fifty years ago to improve gas exchange : proning severe ards (proseva) trial, however, was the milestone which demonstrated mortality benefit in patients with severe ards. nevertheless, few analysis were performed on the effects of the prone position after lung transplantion (lt). the aim of the study is therefore to relate lt primary graft dysfunction (pgd) pathophysiology, which occurs in postoperative setting, to prone-positioning effects on ventilation-perfusion matching, improved lung compliance and clinical outcomes of impairedorgan patients.

lung transplant is the final stage of intervention in dramatic respiratory failure unresponsive to other medical or surgical treatments: reduced disability, improved life quality and extended life are outweighed by still high mortality and morbidity of lt, compared to other solid organs transplants. lt patient survival is undermined, above all, by pgd onset up to 72h in postoperative scenario. acute lung injury, characterized by reperfusion and ischemia damage, evolves in pulmonary edema and severely inflammed graft status. tipical radiological findings are bilateral spreading infiltrates, whose treatment was until some years ago mainly supportive, i.e. protective mechanical ventilation and fluid restriction. two retrospective studies recently demonstrated favorable oxygenation response in terms of pao2/fraction-of-inspired-oxygen (fio2) ratio and lung compliance. our purpose was to broaden gas-exchange results by the analysis of short-term outcomes (i.e duration of mechanical ventilation, reintubation or tracheostomy, anastomotical complications, organ rejection in 30 days, acute kindney injury development and/or filtration necessity, hospital length and mortality). our aim is to assess through this pilot study if early pronation (realized within 24 hours from admission) has a more favorable outcome on patients developing moderate/severe pgd within the first 24 postoperative hours.

Eligibility criteria:
inclusion criteria: * age \> 18 y.o. * first bilateral lung transplant * pgd grade 2 or 3 within 24 hours from icu admission admission to icu for post-operative monitoring after ltx * written informed consent obtained exclusion criteria: * age \< 18 years old * pgd\<2 * single transplant * re-transplant * imv, venous-venous (v-v) or venous-arterial (v-a) extracorporeal membrane oxygenation (ecmo) before surgery * contraindications to prone positioning * refusal of consent

Keywords: pronation, end-stage lung disease
availability of venous conduits in patients with varicose veins for arterial bypass surgery

Conditions: Varicose Veins; Peripheral Arterial Disease

Summary: patients with pad having superficial femoral artery (sfa) occlusion were consecutively enrolled. demographic data and medical history were taken. physical examination and duplex ultrasound were performed.

patients with pad having superficial femoral artery (sfa) occlusion were consecutively enrolled. demographic data and medical history were taken. physical examination and duplex ultrasound were performed. the investigators registered presence of varicose veins, type of previous invasive procedure and availability of saphenous trunks as possible grafts

Eligibility criteria:
inclusion criteria: * older than 18 years exclusion criteria: * those unwilling to sign an informed consent were also included.

Keywords: varicose veins peripheral arterial disease phlebectomy
online adaptive radiotherapy for nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: in this multicenter, prospective, randomized, controlled, non-inferiority phase iii clinical trial, treatment-naïve patients with nasopharyngeal carcinoma (npc) without metastasis will be enrolled for curative radiotherapy. the participants will be randomly assigned to two groups. the experimental group will receive online adaptive radiotherapy (art) during the radiotherapy process, with a smaller ptv margin, while the control group will use original treatment plan during full-course radiotherapy, with a ptv margin of 3 mm. the study aims to compare the survival, adverse events, and quality of survival between the two groups, with the primary endpoint being the locoregional recurrence-free survival rate. the main objective is to determine the role of online art in nasopharyngeal carcinoma, elucidating its potential to alleviate radiation toxicity in patients while ensuring treatment efficacy.


Eligibility criteria:
inclusion criteria: 1. newly diagnosed nasopharyngeal carcinoma confirmed by pathology, with a histological classification of non-keratinizing carcinoma (according to the world health organization, who), pathological classification. 2. no evidence of distant metastasis (m0). 3. age between 18 and 70 years. 4. eastern cooperative oncology group (ecog) performance status score:0-1. 5. undergoing radical intensity-modulated radiation therapy (imrt). 6. no claustrophobia and able to remain in a fixed position for at least 30 minutes 7. patients must be informed of the main content of this study, sign an informed consent form, and be willing and able to comply with the treatment, follow-up plan, laboratory tests, and other requirements specified in the study protocol. exclusion criteria: 1. histological types include squamous cell carcinoma or basal cell carcinoma. 2. radiation therapy intended for palliative care. 3. history of malignant tumors, excluding adequately treated basal cell carcinoma, squamous cell carcinoma, and cervical intraepithelial neoplasia. 4. pregnant or lactating women (women of childbearing age should undergo pregnancy testing; effective contraception should be emphasized during treatment. 5. previous radical radiotherapy for nasopharyngeal cancer. 6. primary and neck metastatic lesions treated with chemotherapy or surgery. 7. presence of other serious underlying diseases that may pose a greater risk or affect compliance with the trial. examples include unstable cardiac diseases requiring treatment, renal diseases, chronic hepatitis, poorly controlled diabetes (fasting blood glucose \&amp;gt; 1.5×uln), and psychiatric disorders. 8. initial assessment of treatment efficacy more than 120 days after the end of radiotherapy. 9. inability to undergo enhanced magnetic resonance imaging due to contrast agent allergies, claustrophobia.

Keywords: nasopharyngeal carcinoma online adaptive radiotherapy smaller ptv margin
a smart-wrist band connected mobile application for the assessment and management of dementia symptoms

Conditions: Dementia, Mild

Summary: in this study, we developed a mobile application that will enable caregivers to continuously monitor the vital health, medication, activity, and location of the patients with mci with a smart wristband while enabling them caregivers to track the progress of the disease by a machine learning model that predicts mmse of the patient using speech

3-month vital health data collection has been performed on 30 participants who are over 60 years old via smart fitness wristbands distributed to them. a mobile application has been developed that caregivers can register their patients, wristbands and allow them to monitor their health data along with their location. medication and activities while synchronizing data anonymously to the application database. the data collection has been performed with relatively cheap, simple xiaomi mi band 7 wristbands that track only hr, rhr, sleep, steps and move minutes due to reasonable price and light weight and easy wearability of these devices. mobile application synchronizes data from wristband to application servers continuously using google fit services that synchronize with device software. this made it possible for the patient's data to still be collected when he or she is not using any of them. mmse scores of patients were taken at the beginning and at the end of the 3 month period to correlate scores with the collected aggregated health data and patient information

Eligibility criteria:
inclusion criteria: * older patients who are willing to wear a smart wristband and have an android smart phone exclusion criteria: -

Keywords: dementia health data fitness tracking
a pilot exercise study for ptsd in women veterans

Conditions: Posttraumatic Stress Disorder

Summary: the overall aim of this pilot feasibility study is to determine if 12-week moderate intensity exercise can safely alleviate posttraumatic symptoms in premenopausal women veterans. specific aims of the study are to; 1. determine the feasibility, safety, and tolerability of 12-week moderate intensity exercise 2. explore potential therapeutic benefits of 12-week moderate intensity exercise. outcome data will include posttraumatic and depressive symptoms. 3. explore potential therapeutic effects of a 12-week moderate intensity exercise on comorbid pain syndrome and quality of life.


Eligibility criteria:
inclusion criteria: 1. women veterans ages 18 and older 2. premenopausal women of childbearing potential with a negative pregnancy test 3. dsm iv-tr confirmed ptsd related to any traumatic event as measured by clinician administered ptsd scale (caps) with a caps score of at least 45 4. relatively low sedentary life style 5. existing psychotropic medications are allowed if on a stable dose 6. evidence-based psychotherapy (e.g. cognitive processing therapy or prolonged exposure) is not allowed to start of the study. however supportive or educational groups that are not ptsd-focused are allowed. exclusion criteria: 1. other psychiatric diagnoses including bipolar disorder, schizophrenia, schizoaffective disorder, active substance dependence/abuse (use in the past 1 month), obsessive-compulsive disorder, and eating disorders.comorbid major depressive disorder, dysthymia and generalized anxiety disorders are not excluded. 2. serious psychopathology 3. actively suicidal or homicidal 4. psychiatric hospitalization within the past 30 days 5. active medical conditions that preclude the use of aerobic exercise such as uncontrolled hypertension, active musculoskeletal degenerative conditions, and symptomatic cardiovascular or respiratory conditions.

Keywords: posttraumatic stress disorder ptsd aerobic exercise women veteran
accu-chek® connect at school (cats) pediatric study

Conditions: Diabetes Mellitus, Type 1

Summary: this interventional, 6-month post-marketing study is designed to evaluate the change in diabetes-related distress among parents/caregivers of school-age children and adolescents with type 1 diabetes (t1d) who are receiving multiple daily injections (mdi) therapy. investigational sites will be assigned using cluster randomization, with approximately 10 to 20 children at each site. in order to maintain a true control group for comparison, the investigational sites will be randomly assigned to the accu-chek® connect diabetes management system (dms) or usual care/continued use of current dms devices.


Eligibility criteria:
inclusion criteria: * children or adolescents, aged 6 to 18 years * diagnosis of t1d for at least 3 months * currently managed with insulin multiple daily injection (mdi) therapy * attending full-day school schedule in grade k through 12 * able to provide smbg data minimum of one month prior to study start * currently using a compatible smartphone with ability to download the accu-chek® connect system app accordingly or ability to utilize smartphone and accu-chek® connect system app as provided for use in study * adolescents (18 years) with diabetes provide written informed consent * children 7 to 17 years to provide age-appropriate child assent * parent/caregiver currently using a compatible smartphone with ability to receive short message service/multimedia messaging service (sms/mms) messages * able to read/write in english and comply with study procedures, including provision of self-monitoring blood glucose (smbg) data at least 1 month prior to the study exclusion criteria: * current or planned use of continuous subcutaneous insulin infusions during the study period * use of continuous glucose monitoring or a remote data-sharing system/device (i.e. nightscout, dexcom share, medtronic connect) during the study * pregnancy * clinically significant medical condition(s) such as anemia, major organ system disease, infection, psychosis, or cognitive impairment * requirement for chronic steroids, immunomodulatory medication, or chemotherapy in adrenal suppressive doses * visual impairment preventing use of the accu-chek® connect system * parent/caregiver is an investigator, general practitioner, practice staff, pharmacist, research assistant, or other staff or relative of those directly involved in the study