Kornimate/medical-research-clean huggingface dataset:
vitamin d and fish oil for autoimmune disease, inflammation and knee pain

Conditions: Autoimmune Diseases; Systemic Inflammatory Process; Knee Pain Chronic; Osteoarthritis; Rheumatoid Arthritis

Summary: the vitamin d and omega-3 trial (vital; nct 01169259) is a randomized clinical trial in 25,871 u.s. men and women investigating whether taking daily dietary supplements of vitamin d3 (2000 iu) or omega-3 fatty acids (omacor® fish oil, 1 gram) reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. this ancillary study is being conducted among vital participants and will examine whether vitamin d or fish oil have effects upon a) autoimmune disease incidence, b) biomarkers of systemic inflammation, and c) chronic knee pain. blood samples at baseline and in follow-up will be collected in a randomly selected subcohort of 1500 individuals and analyzed for changes in biomarkers of systemic inflammation: c-reactive protein, interleukin-6, and tumor necrosis factor-receptor 2. approximately 1300 individuals with chronic, frequent knee pain will be followed with annual questionnaires to evaluate the effects of the supplements on chronic knee pain.


Eligibility criteria:
as for the parent trial, vitamin d and omega-3 trial (vital; nct 01169259). individuals with chronic, frequent knee pain at study baseline will be followed as a subcohort. trial enrollment complete.

Keywords: vitamin d omega-3 fatty acid fish oil prevention trial autoimmune disease rheumatoid arthritis psoriasis systemic inflammation interleukin-6 c-reactive peptide tumor necrosis factor osteoarthritis
investigating the effect of 4-week omega-3 polyunsaturated fatty acid supplementation on inflammation

Conditions: Healthy

Summary: investigate the in vivo effects of n-3 pufa supplementation on inflammation, gene expression and epigenetic signatures. ex vivo stimulation of peripheral blood mononuclear cells (pbmcs) collected pre and post n-3 supplementation and measurement of it's effect on inflammation, gene expression and epigenetic signatures.


Eligibility criteria:
inclusion criteria: * healthy males * aged between 18 and 30 years exclusion criteria: * females (due to differences in cell membrane incorporation of n-3 pufas between the sexes and the testing schedule being unable to fit in with menstrual cycle, therefore altering the blood markers that are being measured). * aged below 18 or above 30. * body mass index (bmi; in kg/ m2), below 18 or above 30. * use of vitamin or fish oil supplements in the last 6 months. * high habitual oily fish consumption (\<4 servings per month). * smoking. * changes in weight in the past 6 months (dieting) or planning on changing dietary habits. * habitual use of anti-inflammatory drugs. * self-reported history of diabetes. * history of heart disease, coagulation/bleeding disorders, metabolic disease or serious allergy. * known to have blood-borne virus. * receipt of inoculations within 2 months of starting the study or the intention to receive such during the study. * donation of or intention to donate blood within 8 weeks of the first sample or at any point during the intervention.
effectiveness of dance on patients with fibromyalgia

Conditions: Fibromyalgia

Summary: the aim of the present study is to assess the effectiveness of belly dance as a treatment for pain and improving the quality of life of patients with fibromyalgia. eighty female patients with fibromyalgia between 18 to 65 years were randomly allocated to a dance group (n=40) and control group (n=40). patients in the dance group underwent 16 weeks of belly dance twice a week, while the patients in the control group remained on a waiting list. patients were evaluated with regard to pain (visual analogue scale), function (6 minute walk test), quality of life (fibromyalgia impact questionnaire and sf-36), depression (beck inventory), anxiety (state-trait anxiety inventory) and self-image (body dysmorphic disorder examination) questionnaire. evaluations were carried out at baseline, after 16 weeks and after 32 weeks.


Eligibility criteria:
inclusion criteria: * classification of fibromyalgia based on the criteria of the american college of rheumatology * female gender * aged between 18 and 65 years exclusion criteria: * not having altered treatment in previous three years * having signed a term of informed consent * patients with other rheumatic diseases, painful osteoarticular conditions, uncontrolled cardiopulmonary disease, diseases of the lower limbs or uncontrolled diabetes were excluded

Keywords: fibromyalgia treatment dance randomized controlled study exercise
el paso public health biorepository

Conditions: Oral Disease; Bacterial Disease

Summary: the prevalence of tooth decay and other oral diseases are overlooked indicators of overall public health. to improve the understanding of oral health in el paso, the city of el paso health department will work with texas tech university health sciences center at el paso to determine factors that contribute to poor oral health, and lead to cavities and periodontitis. the team will collect saliva from children and young adults to study oral infections, markers of inflammation, and other contributors to oral illnesses in mexican-american individuals.

as per summary above.

Eligibility criteria:
inclusion criteria: * individuals seen at the city of el paso dental or pediatric clinics ages 10-21 * healthy children and patients that are likely to be seen in the clinics within the predetermined follow-up time of 6 months exclusion criteria: * patients under 10 years of age and over 21 years of age.
vats for resection of mediastinal parathyroids

Conditions: Mediastinal Parathyroid Adenoma; Hyperparathyroidism

Summary: background: hyperparathyroidism (hpt) is a disease caused by hypersecretion of one or more parathyroid glands, it can be associated with ectopic mediastinal parathyroid glands (mepa) in 2% of cases. the use of video-assisted thoracoscopic surgery (vats) for the surgical resection of these glands is a safe, cost-effective, and low-morbidity option for patients with mepa. we report a case series of patients with this disease managed with vats. patients \& methods: from 2008 to 2022, a retrospective study involving patients with mepa and treated by vats approach was performed in a tertiary hospital in mexico city. relevant biochemical and clinical variables such as imaging studies, pre and postoperative lab results, surgical strategy and outcomes, and pathological analyses were analyzed.

hyperparathyroidism (hpt) is a clinical disorder characterized by an inappropriately elevated paratohormone (pth) due to hypersecretion of one or more parathyroid glands, that may develop secondary hypercalcemia and other metabolic disturbances. this disease includes various signs and symptoms such as nephrolithiasis, osteopenia and osteoporosis, depression, mental numbness, loss of appetite, nausea, vomiting, constipation among others. the abnormal secretion of pth is most commonly caused by a single parathyroid gland adenoma in 85% of the cases, in the other 15% is due to multiple gland hyperplasia (15-20%)(1) or rarely from a parathyroid carcinoma (\<1%). hpt occurs in both genders equally around the sixth decade(2). world hpt prevalence is estimated at 1 in every 500 women and 1 in every 2000 men(3). mediastinal ectopic parathyroid adenomas (mepa) are rare tumors, constituting 1-2% of all parathyroid adenomas. these glands are inferior to the sternal notch and their location may vary from the superior mediastinum to the pericardium and diaphragm(4). the first report of a mediastinal parathyroid adenoma was in 1932 by churchill in the patient captain charles e. martell, who had 6 prior cervical explorations for his hyperparathyroidism until an ectopic gland was found in the superior mediastinum(5). before the introduction of vats, mepa were usually resected by thoracotomy or a median sternotomy, currently with the daily use of minimally invasive surgery, vats is being adopted as the procedure of choice. the aim of this study to report a case series of patients with mepa treated with vats, along with a literature review.

Eligibility criteria:
inclusion criteria: * patients with mepa exclusion criteria: * incomplete records

Keywords: hyperparathyroidism video-assisted thoracoscopy surgery mediastinal ectopic parathyroid adenoma
an efficacy and safety study of apx001 in non-neutropenic patients with candidemia

Conditions: Candidemia

Summary: this is a multicenter, open-label, non-comparative, single-arm study to evaluate the efficacy and safety of apx001 for the first-line treatment for candidemia including suspected or confirmed antifungal-resistant candidemia in non-neutropenic patients 18 yeas of age and older. suspicion of antifungal-resistant candidemia is sufficient (documented resistance is not required for enrollment). the study drug treatment period of apx001 will be a maximum of 14 days. after completion of 14 days study drug therapy, if further antifungal treatment is indicated to complete treatment of candidemia in accordance with standard practice guidelines, fluconazole (unless susceptibility results warrant alternative antifungal therapy) may commence for up to a further 7 days. there will be a follow up period of 4 weeks (+4 days) after eot. the total duration of participation in the study is up to approximately 7.5 weeks. this study will be conducted at approximately 20 sites in the united states and globally.


Eligibility criteria:
key inclusion criteria: * provision of written consent * adults ages 18 and above male or female * new diagnosis of candidemia * able to have pre-existing intravascular catheters removed and replaced (as necessary) key exclusion criteria: * neutropenia * deep-seated candida-related infections * hepatosplenic candidiasis * received more than 2 days of prior systemic antifungal treatment for current candidemia episode * severe hepatic impairment
melanocortin 4 receptor mutations and obesity-associated diseases

Conditions: Obesity

Summary: mutations in the melanocortin 4 receptor (mc4r) are the most common form of monogenic obesity, and can explain 2-6% of severe obesity. studies have shown that mutations in mc4r are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. in adults, mutations in mc4r are less penetrant for these phenotypes but it has been observed that individuals with mc4r mutations have a smaller than expected blood pressure for their degree of obesity. the purpose of this study is to explore the association between functional mc4r mutations and obesity, insulin resistance and blood pressure.


Eligibility criteria:
inclusion criteria: * age 18-70 years * men and women * bmi \> 30 kg/m\^2 exclusion criteria: * uncontrolled type 2 diabetes * bariatric surgery * use of anti-obesity medication

Keywords: obesity mc4r blood pressure blood glucose
cardiovascular effects of sporting events

Conditions: Coronary Heart Disease

Summary: major sporting events may have adverse cardiovascular effects in subjects with coronary heart disease. we also hypothesized that the adverse cardiovascular effects of sporting events are a result of psychobiological processes including stress-induced hemodynamic changes, autonomic dysfunction and parasympathetic withdrawal, and inflammatory and prothrombotic responses, all of which may in turn promote myocardial ischemia.

observational studies suggest that exposure to sporting events may worsen symptoms of angina and trigger acute myocardial infarction. the mechanisms for this association are unknown. to date, there have been no controlled exposures in patients with coronary heart disease: an important population who may be particularly susceptible to the adverse cardiovascular effects of sporting events. in a randomized crossover controlled study, 38 patients with prior myocardial infarction will be exposed to sporting events or not. myocardial ischemia will be quantified by st-segment analysis using continuous 12-lead electrocardiography, and blood pressure change will be analyzed using ambulatory blood pressure monitoring. autonomic function will be assessed by heart rate variability. ischemic, inflammatory and prothrombotic markers will also be measured.

Eligibility criteria:
inclusion criteria: * previous myocardial infarction (\>6 months previously)treated by coronary revascularization * on standard secondary preventative therapy exclusion criteria: * angina pectoris (canadian cardiovascular society grade ≥2) * history of arrhythmia * uncontrolled hypertension * unstable coronary disease (acute coronary syndrome or unstable symptoms within 3 months) * occupational exposure to sporting events * diabetes * hepatic or renal failure

Keywords: sporting events stress myocardial ischemia st-segment depression blood pressure
the support-pro online platform for healthcare professionals treating individuals living with t1d

Conditions: Educational Activities

Summary: health care professionals (hcps) help an support patients living with type 1 diabetes (pwt1d) who need to achieve optimal blood glucose control in order to prevent short and long term complications of t1d. however, studies show that not all hcps are aware of t1d management as most of them only see pwt1d occasionally. this makes it difficult for hcps to remain aware of the particularities of the condition and stay up-to-date on rapidly evolving technologies and therapies available. moreover, low confidence levels and the inaccessibility to continuing medical education on the specificities of new therapies and technologies might increase the failure of hcps to propose the optimal treatment plan to their pwt1d. the support online platform, that was first developed for pwt1d, was adjusted to suit the needs of hcps (support-pro). the regularly updated bilingual (english and french) peer-reviewed content of support, which covers the various elements that an individual with t1d needs to know to manage the disease and aims at making a better use of technologies and new therapies, is the first in its kind and is highly relevant for hcps. the main objective of this study is to determine if the support-pro online training platform can increase hcps' (dietitians, nurses, pharmacists, medical doctors) confidence level in treating individuals with t1d. this study is a non-randomized pre-post trial. we hypothesize that the training provided through the support-pro online platform will significantly increase hcps' confidence level in treating individuals with t1d after 3 months when compared to their confidence level before the intervention.


Eligibility criteria:
inclusion criteria: 1. certified health care professional (nurse, physician (including resident in medicine), dietitian, pharmacist) who is member of a regulatory body in canada 2. self-reported working with at least 1 patient with type 1 diabetes in the last six months 3. has access to the internet 4. use of an active email address 5. comprehension of english or french exclusion criteria: 1. certified diabetes educators 2. working in a t1d specialized clinic 3. living with t1d 4. currently living with someone with t1d (e.g. kid, partner, etc.) 5. working in the pharmaceutical industry

Keywords: type 1 diabetes
efficacy assessment of systematic treatment with folinic acid and thyroid hormone on psychomotor development of down syndrome young children

Conditions: Down Syndrome

Summary: evaluation of the following in very young children with down syndrome: * the efficacy of systematic treatment with l-thyroxine at controlled doses (clinically and by ultrasensitive thyreostimulating hormone (tsh) assay), * the efficacy of systematic folinic acid treatment at a dose of 1 mg/kg/o.i.d, * any interaction between these two treatments.


Eligibility criteria:
inclusion criteria: * patient with a karyotype demonstrating homogeneous, free or robertsonian translocation trisomy 21 * patient having undergone a cardiac ultrasound not demonstrating any severe heart disease * patient aged 6 to 18 months at inclusion exclusion criteria: * congenital hypothyroidism * hypothyroidism demonstrated by laboratory tests (tsh \> 7mui/l) * presenting or having presented hyperthyroidism * presenting or having presented leukaemia * presenting or having presented west syndrome or any other form of epilepsy or unstable neurological disease * presenting or having presented signs of central nervous system distress: stroke, postoperative hypoxia, meningitis) * presenting severe heart disease on cardiac ultrasound, with haemodynamic effects * presenting non-controlled cardiac arrhythmia * apgar \< 7 to 5 min at birth * gestational age \< 231 days (33 gestation weeks)

Keywords: down syndrome young children psychomotor development thyroid hormone folinic acid psychometric tests gmds griffiths genetic factors biochemical factors
the efficacy of tongue exercises on swallowing function in the elderly with mild cognitive impairment

Conditions: Dysphagia, Oropharyngeal

Summary: the purpose of this study is to explore the effects of tongue muscle strength and resistance exercises on dysphagia, tongue muscle strength, oral hygiene, repetitive saliva swallowing, nutrition, depression, and swallowing-related quality of life in frail elderly people with mild cognitive impairment in the community. this is a longitudinal research design using cluster randomization. participants were randomly divided into three groups by computer: experimental group 1 received tongue resistance exercises; experimental group 2 received both tongue strengthening exercises and tongue resistance exercises; and the control group received oral and cheek bulging exercises.

recruitment was carried out in nursing homes, day passport centers, and community care centers in new taipei city and taoyuan city, taiwan. the subjects were elderly people aged 65 years or older with cognitive impairment and frailty, recruited from november 19, 2021, to january 25, 2024.participants were randomly divided into three groups by computer, 30 people per group, group 1 received tongue resistance exercises, group 2 received both tongue strengthening exercises and tongue resistance exercises, group 3: control group received oral and cheek bulging exercises. the exercise intervention is divided into two stages. after completing the pre-test (t1), the first stage of 12 weeks of exercise begins, with evaluations conducted at the 4th week (t2), 8th week (t3), and 12th week (t4). after a 12-week rest period (t5), the second phase of boosters exercise is conducted for another 12 weeks, followed by an immediate post-test (t6) and a final evaluation after another 12 weeks of rest (t7). participants received exercise 6 days a week, 3 times a day (before meals), with each session lasting 30 minutes. before conducting the study, all participants received a complete explanation of the purpose, risks, and procedures of the investigation, and provided written informed consent. procedures were in accordance with the ethical standards of the committee on human experimentation at the institution where the work was conducted, and this study was approved by the institutional review board.

Eligibility criteria:
inclusion criteria: * a. elderly individuals aged 65 years and above. * b. frailty assessment in older adults: score of at least 1 point. * c. cognitive function assessment: score of \>=16 for individuals with no education; \>=20 for those with elementary education; \>=24 for those with junior high school education or higher. exclusion criteria: * a. severe communication barrier. * b. unable to move independently or requires assistance. * c. unable to raise head or neck. * d. recent use of anticholinergic medications, asthma medications, or central nervous system depressants (benzodiazepines). * e. aspiration pneumonia. * f. tracheostomy in place. * g. neuromuscular disorder.
garcinia mangostana l.pericarp gel as a local drug delivery in treatment of chronic periodontitis

Conditions: Generalized Chronic Periodontitis

Summary: a single-center, randomized controlled clinical trial was done to assess the periodontal status of the individuals and the presence of red complex microorganisms (rcm) such as treponema denticola, porphyromonas.gingivalis and tannerella.forsythia in the subgingival tissues of periodontal pockets at baseline followed by the application of mangostana gel as an adjunct to scaling and root planing. the periodontal parameters and rcm were again assessed at 3rd month and compared with the placebo group.

background: the study aim to assess the periodontal status of individuals and the presence of red complex microorganisms (rcm) such as treponema denticola (t.d), porphyromonas gingivalis (p.g) and tannerella forsythia (t.f) in the subgingival tissues of periodontitis subjects before and after the application of 4% mangostana gel (mga) as an adjunct to scaling and root planing. methods: 25 sextants (mga group) were treated with scaling and root planing (srp) and subgingival application of mangostana gel used as local drug delivery (ldd). 25 sextants (placebo group) were treated with srp and placebo gel. clinical parameters were recorded and the presence of rcm were assessed at baseline and at 3rd month. statistical analysis: the mean probing pocket depth, clinical attachment level, bleeding index, plaque index were assessed at 0th day and 3rd month and compared between the groups using one way analysis of co-variance (ancova). intra-group comparison (mga) for the presence of t.d, from baseline to 3rd month and inter-group comparison (mga \& placebo) at 3rd month was done using fischer exact test. in both mga and placebo group, the presence of t.d in subgingival tissues was compared with the clinical parameters at 3rd month using student's t-test. the p ≤ 0.05 was chosen as a level of significance.

Eligibility criteria:
inclusion criteria: * age: 30 to 65 years * systemically healthy subjects with chronic periodontitis exclusion criteria: * aggressive periodontitis, * systemic disorders, * known or suspected allergy to the mga/placebo group, * pregnant and lactating females, * long term steroid medication, * smokers, * alcoholics, * immunocompromised individuals and * those with history of antibiotic or periodontal therapy in preceding 6 months

Keywords: anti-inflammatory agents, antimicrobials, periodontitis
imaging of vitreous opacities in human eyes

Conditions: Floaters; Vitreous Opacities

Summary: vitreous opacities (vos), commonly known as floaters, are dark spots that appear in, and may float across your vision. presently, there is a lack of available data in the literature regarding vos. this study aims to obtain imaging data of vos in the population to build an imaging database of vos to learn more about them.


Eligibility criteria:
inclusion criteria: * aged 18 years or older * svo-related symptoms in vision * clear ocular media, to allow a clear view of the vitreous for the svo-id exclusion criteria: * presence of vitreous hemorrhage * cataract grade 3 and above * opacification of lens, cornea, or vitreous * diagnosis of narrow-angle glaucoma * refractive error is outside the range of -6d to +3d * astigmatism is outside the range of +/- 2d of cylinder