Kornimate/medical-research-clean huggingface dataset:
effectiveness of physical therapy program to treat rotator cuff disorders among nursing professionals

Conditions: Shoulder Impingement Syndrome; Quality of Life; Satisfaction

Summary: the program of stretching, strengthening and proprioception is more effective than stretching and strengthening program in nursing, with rotator cuff disorder, according to indicators of quality of life and job satisfaction.

the study will be conducted at the rehabilitation centre of the hospital of the medical school of ribeirão preto, university of são paulo (usp-hcfmrp). the study will be conducted with nursing staff (nurses, technicians and nursing assistants) hcfmrp-usp. the sample will consist of nursing workers sent by request for referral to a medical diagnosis of rotator cuff disorder in the period may 2010 to august 2011. there was no sample size calculation for this study because the number of subjects directly depends on the demand of patients referred to the department of physical therapy rehabilitation center (cer) in the period of data collection. all patients who met the study inclusion criteria were invited to participate. so, once met the inclusion criteria of the sample, the subjects were randomly allocated to group 1 (control) or 2 (experimental). group 1 was formed by the subjects in the control group in which they were performed stretching exercises, cryotherapy and strengthening the shoulder. group 2 was formed by the subjects in the experimental group were performed in which stretching exercises, strengthening, and cryotherapy proprioceção shoulder.

Eligibility criteria:
inclusion criteria: * working as a nurse * technician or nursing assistant in the hospital * make medical diagnosis of disorder in the rotator cuff (impingement, injury or rupture of the cuff) * does not make a medical diagnosis of cognitive impairment * were receiving no another type of treatment for shoulder pain (eg medicines,acupuncture, massage) * availability and interest in participating in therapy and accept to participate in the survey. exclusion criteria: * patients with pain that would prohibit their participation in the program with a medical diagnosis of cognitive impairment, * associated with debilitating diseases, * previous surgery of the shoulder, * other specific conditions of the shoulder joint (adhesive capsulitis, * degenerative osteoarthritis of the glenohumeral joint, * tendon calcification) and do not accept to join the study.

Keywords: nursing staff physical therapy (specialty)
wearing a compression garment for patients with hypermobility type of ehlers-danlos syndrome

Conditions: Ehlers-Danlos Syndrome Hypermobility Type

Summary: the ehlers-danlos syndrome (eds) is a rare genetic disease caused by an anomaly of the connective tissue. this syndrome has different forms. hypermobility type is the most common. it is characterized by generalized joint hypermobility, associated with a chronic pain syndrome. pains appear as the most frequent demonstration of this syndrome, the worst lived and the most crippling. faced with insufficient effect of drug treatment, other alternatives have been proposed to relieve these patients. compression garments have been developed. they appear as medical devices targeted specifically for patients with hypermobility eds type: in the symptomatic treatment of joint pain, in stabilizing joints by proprioceptive effect and of muscle globulization, and in the functional improvement. the vetcosed study is a quasi-experimental study of type "before / after", monocentric, open. the study is realized in the centre médico-chirurgical et de réadaptation des massues - croix rouge française de lyon, in association with the pôle information médicale evaluation recherche des hospices civils de lyon. this study concerns about 40 patients with eds hypermobility type, which will be followed for 8 weeks: 4 weeks during which they will wear a compression custom-made garment (short-sleeved vest cicatrex sed®), and 4 weeks during which they do not carry this garment. the main objective is to demonstrate the effectiveness of compression garments in the eds hypermobility type, especially in terms of symptomatic improvement joint pain. the main outcomes expected of this study are: * an improvement of the power and the peaks of couple of muscles rotators of shoulders. * a decrease of the pains and the defects of articular stability of the shoulder * an improvement of the quality of life and the functional independence of these patients


Eligibility criteria:
inclusion criteria: * ehlers-danlos syndrome hypermobility type confirmed the diagnosis of a geneticist * with an instability of one or both shoulders, painful or considered invalidating by the patient (recurrent dislocation or subluxation : at least once / month or at least 12 times / year) * having a joint hypermobility syndrome (abnormal mobility and in a non-physiological axis), with a beighton score of greater than or equal to 5 of 9 * age greater than or equal to 18 years * size greater than or equal to 1 m 40 * sufficient understanding of the french language in order to respond to self-report questionnaires exclusion criteria: * hyperalgic episode in progress * unstable cardiac disease * previous history of shoulder surgery * severe skin lesions, * pregnancy in progress

Keywords: ehlers-danlos syndrome hypermobility compression garment pain isokinetic evaluation
study of dwj1351 in healthy male volunteers

Conditions: Healthy

Summary: the purpose of this study is to compare the safety and pharmacokinetic characteristics of combination of amlodipine, olmesartan and rosuvastatin and dwj1351 in healthy male volunteers


Eligibility criteria:
inclusion criteria: * healthy adult male subjects aged 19 to 50 years * subjects whose body weight ≥ 55 kg and body mass index(bmi) ≥ 18.0 kg/m2 and ≤ 27.0 kg/m2 * subject who was judged to be healthy and suitable for the participation by the investigator based on screening test results * subject who provided written informed consent to participate in this study exclusion criteria: * subject who had a severe allergy or allergic reactions to the amlodipine, olmesartan, rosuvastatin or related drugs * subject with sign or symptoms or previously diagnosed disease of liver, kidney, neurology, respiratory, endocrinology, hematology, cardiovascular, digestive system, reproductive system, neurology, psychology, ophthalmic and skin disease * subjects who had a serious clinical illness that can impact fate of drugs absorption * subject who shows vital signs with the number of systolic blood pressure of ≥150 mmhg or ≤100 mmhg, and the number of diastolic blood pressure of ≥100mmhg or ≤66mmhg * subject who have experienced drug abuse * subject who donates his blood (whole blood donation within last 2 months or plasma donation within last 1 month) * subject who has taken other clinical or licensed medication from another clinical trial within an 3-month period prior to the first administration of the study medication
prevalence and characteristics of patients with bronchiectasis comorbid nontuberculous mycobacteria

Conditions: Bronchiectasis; Non-tuberculous Mycobacterial

Summary: the purpose of this study is to understand the prevalence of non-tuberculous mycobacterial(ntm) infections in the middle-aged and old women patients with bronchiectasis in mainland china, and explore the characteristics of patients with bronchiectasis comorbid ntm.

the development of bronchiectasis is closely related to chronic infection of pathogenic microorganisms .bronchiectasis and nontuberculous mycobacterial (ntm) infections are inextricably linked pathophysiologically. but the incidence rate and characteristics of ntm infections among patients with bronchiectasis remains unclear in mainland china. in this study, we will collect data of participants about demographic ,co-morbidities ,spirometry, mmrc score ,exacerbation history, qol-b questionnaire, aetiology, spirometry , hrct(or ct) scan ,results of microbiology samples and treatments, collect three consecutive sputum(or induced sputum) samples to smear, bacteria culture, acid-fast stain, mycobacterium cultivation and identification, drug susceptibility testing of nontuberculous mycobacteria.to estimate the prevalance of non-tuberculous mycobacterial(ntm) infections in middle-aged and old women patients with bronchiectasis in northern china. to analyze clinical manifestations and microbiological characteristics of patients with bronchiectasis comorbid ntm infections by 16srna and gene sequencing. in addition, a cross-sectional investigation about lung function and clinical data will be done among patients who have confirmed bronchiectasis with ntm from february 2017 to december 2020.

Eligibility criteria:
inclusion criteria: 1. middle-aged and old women who are \> or = 50 years of age 2. patients meet the criteria of bronchiectasis exclusion criteria: 1. cystic fibrosis 2. after organ transplantation 3. activity tumor (malignant solid tumor and blood system tumor) 4. pulmonary interstitial fibrosis with bronchus dilation 5. allergic bronchopulmonary aspergillosis 6. diffuse panbronchiolitis 7. patients refused to sign the informed consent 8. patients unable to return sputum specimens

Keywords: bronchiectasis ntm infections middle-aged and old women
a multicenter, randomized, double-blind, comparative study to evaluate the safety, tolerability, and efficacy of 2 dosing regimens of an antifungal drug in the treatment of fungal infections in adults (0991-801)(completed)

Conditions: Invasive Candidiasis

Summary: comparison of the safety and effectiveness of standard drug dosing versus a daily dose 3 times higher than the standard dose in patients with invasive candidiasis (bloodstream and/or systemic yeast infections)


Eligibility criteria:
inclusion criteria: * clinical and laboratory evidence of blood stream \&/or systemic candida infections exclusion criteria: * possible candida contamination * candida colonization (non invasive infection), urine, cardiac, bone or brain and prosthetic device infections * acute or moderately severe liver disease * abnormal liver function tests * abnormal blood clotting for patients on blood thinners
validation of two new questionnaires for dupuytren's disease

Conditions: Dupuytren's Disease

Summary: a study to validate two newly developed questionnaires for dupuytren's disease. the objective is to develop a patient specific outcomes tool for dupuytren's disease. while there are standard and validated questionnaire instruments used to measure health related quality of life and function, they do not address patient specific issues. the investigators will also pilot a treatment/disease specific satisfaction questionnaire for xiaflex use for dupuytren's disease.


Eligibility criteria:
inclusion criteria: * subject has a diagnosis of dupuytren's disease in at least one finger * patients will be 35 years of age or older * patients will be able to read, speak, and understand english * patients will be able to provide voluntary written consent to participate exclusion criteria: * female patients who are nursing or pregnant, or plan to become pregnant during the treatment phase. * patient has a chronic muscular, neurological or neuromuscular disorder that affects the hands. * patient has a known allergy to collagenase or any other excipient of xiaflex. * patient has received any collagenase treatments before the first dose of xiaflex. * any history of or current medical condition which in the investigator's opinion would make the subject unsuitable for enrollment in the study

Keywords: dupuytren's contracture
exercise training six-months after discharge in post-covid-19 syndrome

Conditions: COVID-19 Pneumonia

Summary: the goal of this study investigate the effects of 12-week exercise training on pulmonary function, symptoms, functional capacity, and quality of life (qol) in patients with severe covid 6 months after intensive care discharge. the main question it aims to answer are: 1-does exercise training given in post-covid-19 syndrome have an effect on pulmonary function, symptoms, functional capacity, muscle strength and quality of life? 25 severe post-covid patients (35 m) were in exercise group (eg) (age=52.9±11 years, 18m), and 25 (age=53.6±11.9 years, 17m) were in the control group (cg). eg received aerobic exercise (30-min walking) and upper and lower extremity strength training for 12 weeks for 3 days/week. cg continued only routine follow-up.


Eligibility criteria:
inclusion criteria: * covid-19 pneumonia patients were followed up for at least 24 h in the icu. those post-covid six months who could cooperate with the tests and volunteered to participate were included. exclusion criteria: * individuals with pulmonary, orthopedic, neurological, vestibular, and psychological problems diagnosed before covid-19 infection; myocarditis developed after covid-19 infection; and those pregnant and those having any other acute diseases (such as infection and trauma) that would prevent performing the tests and/or interfering with the test results were excluded.

Keywords: post-covid-19 lung function fatigue aerobic exercise strength training
can a simple trephination increase the heeling potential for all-inside meniscal repair in the vascular zone?

Conditions: Rupture; Meniscus, Bucket Handle

Summary: meniscus does not always heal when sutured. the investigators will make small holes in the meniscus before repair to promote more bleeding. the investigators expect that will help the meniscus to heal better.

rct study to evaluate the effect on trephination together with meniscal repair on meniscus healing after repair.

Eligibility criteria:
inclusion criteria: * adults who have a meniscus repaired. exclusion criteria: * meniscus not fit for repair. * patients not fit for the repair regime. * arthrosis \> stadie 2 (icrs). * prior attempt of repair of the meniscus.
a study to evaluate the safety and tolerability of pf-06342674 (rn168) in subjects with multiple sclerosis (ms)

Conditions: Multiple Sclerosis

Summary: pf-06342674 (rn168), being developed for the treatment of multiple sclerosis (ms), is an antibody that binds to and inhibits the human interleukin-7 receptor, a component potentially involved in ms. pf-06342674 (rn168) is expected to play a role in slowing down the progression of the disease.


Eligibility criteria:
inclusion criteria: * women and men aged 18-55 yrs. * confirmed diagnosis of multiple sclerosis (ms) according to the 2010 revision of the mcdonald criteria. * expanded disability status scale (edss) between 0-5, inclusive. exclusion criteria: * relapse episode of ms within 2 weeks of enrollment. * primary progressive ms without a relapsing component. * intolerant or unwilling to undergo mri scanning. treatment with disease modifying agents up to 6 weeks prior to enrollment.

Keywords: multiple sclerosis mri
sunshine 2 study for women with diabetes

Conditions: Diabetes; Depression; Quality of Life

Summary: this is a randomized clinical trial (rct) to determine the effectiveness of vitamin d3 supplementation on depressive symptoms, self-management, and blood pressure in approximately 180 adult women with type 2 diabetes who have significant depressive symptoms. consenting adult women who are eligible to participate will be randomly assigned to either a weekly dose of 50,000 international units of vitamin d3 supplementation or a matching weekly active comparator of 5,000 international units of vitamin d3 for six months. participants will complete approximately four in-person study visits and several telephone visits throughout the six month trial period, where the researchers will assess depressive symptoms, diabetes self-management, and systolic blood pressure.

the primary aim of this study is to determine the effect of vitamin d supplementation on depressive symptoms, self-management, and systolic blood pressure compared to placebo. the hypothesis is that women receiving vitamin d supplementation will report fewer depressive symptoms, increased diabetes self- management mediated by depression improvement, and will have a lower systolic blood pressure compared to those taking placebo at three and six months follow-up. the secondary aim is to explore the mechanistic effect of vitamin d supplementation on inflammatory biomarkers and their association with depression. here, the hypothesis is that women receiving vitamin d supplementation will have a decrease in inflammatory biomarkers which will be associated with fewer depressive symptoms compared to those taking placebo at three and six months follow-up.

Eligibility criteria:
inclusion criteria: * women age 21 and older * objective evidence of depressive symptoms at the screening and baseline visits * diagnosis of type 2 diabetes currently being treated by a healthcare provider * blood vitamin d level less than 32 nanograms-per-deciliter (32 ng/dl) exclusion criteria: * current alcohol or substance use disorder * any unstable or severe psychiatric disease including diagnoses of schizophrenia, bipolar affective disorder, dementia, delirium, or other psychotic disorder * severe complications of diabetes, such as blindness and/or amputation * any malabsorption disorder, such as crohn's disease and/or celiac sprue * elevated serum calcium level deemed significant by the principal investigator * use of 1,000 or more international units daily vitamin d 60 days before enrollment and unwillingness to discontinue vitamin d supplementation 30 days before enrollment. * use of st. john's wort and unwillingness to discontinue st. john's wort three weeks prior to enrollment. * participants who are pregnant, nursing, or planning to become pregnant during the study. * baseline systolic blood pressure (sbp) greater than 160 millimeters of mercury (mmhg) or diastolic blood pressure (dbp) greater than 100 mmhg. * other serious medical conditions (e.g., cancer, multiple sclerosis, etc.) deemed clinically significant by the principal investigator

Keywords: vitamin d diabetes self-management depression women
effects of virtual reality game on upper extremity function for stroke

Conditions: Stroke

Summary: virtual reality training had already been used in stroke rehabilitation, and previous studies supported that it could improve upper extremity ability and increase motivation and pleasure than conventional methods. pablo is a new vr game combined with motion sensor system which can detect subject's activities. unlike commercial camera systems such as kinect or xbox, the systems require a continuous sightline or enough active range of motion which may increase risk of compensatory movement. few of studies had investigated the rehabilitation effects on upper extremity with pablo for patients with stroke.the purpose of this study is to investigate the effects of virtual reality upper extremity training through pablo system in patients with chronic stroke.

purpose: the purpose of this study is to investigate the effects of virtual reality upper extremity training through pablo system in patients with chronic stroke. methods:patients with mild to moderate motor deficits were recruited and randomly assigned to "vr plus standard rehabilitation group"(n=19), and "standard rehabilitation group" (n=19). after 12 training sessions (60 minutes a time, 2 times a week), the performance was assessed by a blinded assessor. the outcome measures included fugl-meyer assessment-upper limb section(fmaue), box and block test(bbt), dynanometer, active range of motion of shoulder and elbow,and stroke impact scale.modified physical activity enjoyment scale and adverse effect were recorded after each sessions.collected data will be analyzed with sample t test by spss version 20.0, and alpha level was set at 0.05.

Eligibility criteria:
inclusion criteria: * first stroke with hemiplegia, * chronicity of \>6 months * could understand instructions * brunnstrom stage of ue ≥iv. exclusion criteria: * patients who were aged \ 75 years * patients with visual or auditory impairment who were unable to see or hear the feedback from the device clearly * montreal cognitive assessment \<16 * modified ashworth scale score of \>2 * patients with other medical symptoms that can affect movement were excluded.
treadmill training with additional body load: effects on gait of subjects with parkinson´s disease

Conditions: Parkinson´s Disease

Summary: background: studies about the effects of walking training with additional body load in parkinson's disease (pd) are lacking. there is evidence that the increase of body load during treadmill walking improves reflex activity and leg extensor muscle activity, which are impaired in subjects with pd. purpose: the purpose of this study was to assess the effects of treadmill walking training with additional body load on the ground reaction forces, spatiotemporal, and kinematic variables of the gait of subjects with moderate pd. design: this study was an a1-b-a2 single-case. setting: the evaluation and the training were conducted in a movement analysis laboratory, and at the rehabilitation unit of the university, respectively. participants: nine patients with pd (hoehn and yahr 2 through 3) and gait disturbances. interventions: phases a1 and a2 included 6 weeks of gait training on a treadmill with 10% increase of normal body mass. phase b included 6 weeks of conventional physical therapy. measurements: measures included the ground reaction forces, spatiotemporal, and kinematic variables during overground walking, at baseline and after each phase.


Eligibility criteria:
inclusion criteria: * idiopathic pd (previously diagnosed by one specialist physician,) * hoehn and yahr (h-y) stages 2 through 3, * absence of dementia (mini-mental status examination - mmse, defined according to educational level) and, * capacity to ambulate independently for at least 10 meters. exclusion criteria: * change medication (dopaminergic) during the study period, * use treadmill for at least six months prior to the study, and * other neurologic problems or musculoskeletal, cardiovascular and respiratory disease or uncorrected visual deficit that could represent risk and interfere in the performance of the training.

Keywords: treadmill body load parkinson's disease gait