Kornimate/medical-research-clean huggingface dataset:
the effects of horner's syndrome developing after interscalene brachial plexus block on autonomic nervous activity

Conditions: Brachial Plexus Block; Horner Syndrome; Autonomic Imbalance

Summary: this study evaluates the effects of horner's syndrome on cardiac autonomic nervous activity after interscalene brachial plexus block. cardiac autonomic nervous activity and bilateral pupil diameters will be measured in a scotopic light condition, 30 minutes after interscalene brachial plexus block under ultrasound guidance and 15 minutes after the subsequent sitting position.

stellate ganglia provide sympathetic fibers to the heart. ipsilateral stellate ganglion block accompanied by interscalene brachial plexus block causes horner's syndrome presenting with miosis, ptosis, and anhidrosis. the extent of horner's syndrome can be represented by the difference in pupil diameter between bilateral eyes. cardiac autonomic nervous activity affected by stellate ganglion block can be measured by calculation of heart rate variability parameters.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists physical status 1 * arthroscopic shoulder surgery under interscalene brachial plexus block exclusion criteria: * coagulopathy * infection at the site of brachial plexus block * peripheral neuropathy or neurologic sequelae on the operative limb * allergy to local anesthetics or history of allergic shock * psychiatric diseases * patient refusal * difficulty communicating with medical personnel * arrhythmias * ischemic heart disease * hypertension * diabetes mellitus * thyroid dysfunction * conduction abnormalities on electrocardiogram * electrolyte imbalance * medications affecting cardiac conduction * contralateral vocal cord palsy * contralateral hemidiaphragmatic paresis or paralysis * contralateral pneumothorax or hemothorax

Keywords: heart rate variability mesopic pupil size
study comparing adapalene gel 0.3% to differin® and both to a placebo control in treatment of acne vulgaris

Conditions: Acne Vulgaris

Summary: the objectives of this study are to evaluate the therapeutic equivalence and safety of adapalene gel 0.3% and differin® (adapalene gel 0.3%).

the objectives of this study are to evaluate the therapeutic equivalence and safety of adapalene gel 0.3% and differin® (adapalene gel 0.3%) in the treatment of acne vulgaris and to demonstrate the superiority of the efficacy of the test and reference products over the placebo.

Eligibility criteria:
inclusion criteria: * healthy male or non-pregnant female aged ≥ 12 and ≤ 40 years with a clinical diagnosis of acne vulgaris. * subjects aged 18 years and older must have provided written consent. subjects aged 12 to 17 years must have provided written assent accompanied by written consent from their legally acceptable representative. all subjects or their legally acceptable representatives must sign health insurance portability and accountability act authorization. * must have a minimum of ≥ 25 non-inflammatory lesions and ≥ 20 inflammatory lesions and ≤ 2 nodulocystic lesions at baseline on the face. * must have a definite clinical diagnosis of acne vulgaris severity grade 2, 3, or 4 as per the investigator's global assessment. exclusion criteria: * female subjects who are pregnant, nursing or planning to become pregnant during study participation. * have a history of hypersensitivity or allergy to adapalene, retinoids and/or any of the study medication ingredients. * presence of any skin condition that would interfere with the diagnosis or assessment of acne vulgaris.
efficacy and cost-effectiveness of spasticity treatment with multifocal tens

Conditions: Spasticity; Stroke; Cerebral Palsy

Summary: spasticity is a common consequence of injury to the central nervous system and can be a major problem in motor function and everyday activities. a method for treating spasticity that applies low-amplitude electrical stimulation through a garment with built-in electrodes, mollii® (elektrodress), has been developed. the garment is to be used in combination with individualized training and the stimulation is mainly given to antagonists of spastic muscles. the general objective of this study is to evaluate the efficacy of and costs associated with the mollii® treatment of spasticity due to stroke or cerebral palsy. primary objectives are; * to study whether treatment with the mollii® improves function and activity * to evaluate the cost-effectiveness of the treatment, from both a health-care perspective and a societal perspective. secondary objectives are; * to study whether there are differences in treatment effect between the stroke and the cerebral palsy groups in a subgroup-analysis * to assess compliance with treatment * to report any adverse effects.

this study is designed as a double-blinded, randomized, cross-over trial (rct). this part of the study takes 12 weeks (6 weeks of active treatment and 6 weeks of non-active treatment) and is followed by a wash-out period of 6 weeks. an uncontrolled,open phase starts after week 18, where patients are followed one year after inclusion. 30 participants with spasticity due to stroke and cerebral palsy will be included. two centers are recruiting participants and are collecting data. outcome measures are chosen to reflect the different dimensions in the international classification of functioning, disability and health (icf) and patient reported outcome measures (prom).

Eligibility criteria:
inclusion criteria: * spasticity due to stroke or cerebral palsy * have some preserved walking ability, with or without walking aids * be able to understand the treatment and instruments/interviews used * for stroke participants, two years should have elapsed since their injury/insult exclusion criteria: * electronic devices * ventriculoperitoneal shunt * arrhythmia * hearth infarction or unstable angina pectoris * symptomatic hyper- or hypotonia * cancer under treatment * unstable psychiatric disease * lung disease, affecting daily life * unstable epileptic disease * orthopedic surgery last year * obesity with bmi \> 35 * infectious disease with longstanding treatment * pregnancy
thoracoscopy for idiopathic pneumothorax in children

Conditions: Spontaneous Pneumothorax; Idiopathic Pneumothorax; Bleb Lung; Child, Only

Summary: the goal of this retrospective study is to describe the outcomes of spontaneous idiopathic pneumothorax treated by thoracoscopy with pleural abrasion and blebectomy. the main questions it aims to answer are: * are there risk factors leading to pneumothorax recurrence? * are pleural abrasion and blebectomy really diminishing the recurrence of pneumothorax?

the investigators describe the outcomes of the participants: length of stay, operating time, type and time before recurrence, occurrence of contralateral pneumothorax also treated by thoracoscopy, with pleural abrasion and blebectomy

Eligibility criteria:
inclusion criteria: * patients younger than 18 years old who had a video-assisted thoracoscopy with pleural abrasion and blebectomy for spontaneous idiopathic pneumothorax exclusion criteria: * patients older than 18 years old who had a video-assisted thoracoscopy with pleural abrasion and blebectomy for spontaneous idiopathic pneumothorax

Keywords: video-assisted thoracoscopy spontaneous idiopathic pneumothorax blebectomy lung wedge pleural abrasion retrospective study child
dynamics of muscle mitochondria in type 2 diabetes exercise

Conditions: Insulin Resistance, Diabetes

Summary: insulin promotes the clearance of sugars from the blood into skeletal muscle and fat cells for use as energy; it also promotes storage of excess nutrients as fat. type 2 diabetes occurs when the cells of the body become resistant to the effects of insulin, and this causes high blood sugar and contributes to a build-up of fat in muscle, pancreas, liver, and the heart. understanding how insulin resistance occurs will pave the way for new therapies aimed at preventing and treating type 2 diabetes. mitochondria are cellular structures that are responsible for turning nutrients from food, into the energy that our cells run on. as a result, mitochondria are known as "the powerhouse of the cell." mitochondria are dynamic organelles that can move within a cell to the areas where they are needed, and can fuse together to form large, string-like, tubular networks or divide into small spherical structures. the name of this process is "mitochondrial dynamics" and the process keeps the cells healthy. however, when more food is consumed compared to the amount of energy burned, mitochondria may become overloaded and dysfunctional resulting in a leak of partially metabolized nutrients that can interfere with the ability of insulin to communicate within the cell. this may be a way for the cells to prevent further uptake of nutrients until the current supply has been exhausted. however, long term overload of the mitochondria may cause blood sugar levels to rise and lead to the development of type 2 diabetes. this study will provide information about the relationship between mitochondrial dynamics, insulin resistance and type 2 diabetes.

the traditional view of mitochondria as isolated, spherical, energy producing organelles is undergoing a revolutionary transformation. emerging data show that mitochondria form a dynamic networked reticulum that is regulated by cycles of fission and fusion. the discovery of a number of proteins that regulate these activities has led to important advances in understanding human disease. data show that activation of dynamin related protein 1 (drp1), a protein that controls mitochondrial fission, is reduced following exercise in prediabetes, and the decrease is linked to increased insulin sensitivity and fat oxidation. the proposed research will test the hypothesis that mitochondrial dynamics is a key mechanism of insulin resistance in type 2 diabetes. the experimental approach harnesses innovative molecular and cellular tools, interfaced with physiologically significant human studies to obtain meaningful data on insulin resistance, and has the potential to generate insights that will lead to new diabetes therapies for future generations.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * body mass index (bmi) between 25 and 50 kg/m2 * hba1c \< 10% * sedentary exclusion criteria: * evidence of type 1 diabetes or requiring insulin therapy * bmi \>50 kg/m2 * smoking * active pregnancy

Keywords: mitochondrial dynamics insulin resistance exercise and diabetes
study for wait and watch suitable in rectal cancer

Conditions: Rectal Neoplasms

Summary: one of the standard treatment options offered to patients of locally advanced rectal cancer is neoadjuvant (treatment given before surgery) radiotherapy \& chemotherapy followed by surgery. in patients whose tumour has completely reduced after neoadjuvant treatment, the wait and watch strategy is also an option. this is another standard treatment option for patients of locally advanced rectal cancers. in this, the patient is monitored after treatment completion. in this study, investigators are only going to observe the patient's response to treatment, monitor their side-effects due to treatment and assess their quality of life using standardized quality of life questionnaires. no additional tests or hospital visits will be required as a part of this study. the patient will be followed up, as per standard follow-up protocol, for at least 2 years after the completion of their treatment.

the standard treatment options offered to patients of locally advanced rectal cancer are neoadjuvant (treatment given before surgery), radiotherapy \& chemotherapy, followed by surgery. in patients whose tumour has completely reduced after neoadjuvant treatment, the watch and wait or non-operative management is an option. in this, the patient is monitored after treatment completion. in this study, investigators will only observe the patient's response to treatment, monitor their side effects due to treatment, and assess their quality of life using standardized quality-of-life questionnaires. the patient will be followed up, as per standard follow-up protocol, for at least two years after the completion of their treatment.

Eligibility criteria:
inclusion criteria: * age more than 18 years. * patients diagnosed with locally advanced rectal cancer and suitable for wait and watch as per international consensus guidelines \[3,1\] * biopsy-proven adenocarcinoma (non-signet or non-mucinous) t1-4a or n0-2, plus limited metastatic disease (metastases in 1to 2 organs or 1to 2 metastases involving a single organ) * non-circumferential disease with ccl less than 7 cm * lower - mid rectum starting upto 7 cm from anal verge * previously treated with the intent of wait-and-watch with tnt or lcrt with or without brachytherapy and completed tnt part of treatment till march 2024(for retrospective cohort). * patients not consenting to ongoing interventional studies, such as the scotch study or any future studies, will be considered and offered * consent to be on standard regular follow-up and answer quality of life questionnaires * patients on lost to follow up will be included if they have completed treatment and taking follow up locally, accepting telephonically to participate. exclusion criteria: * not eligible as per the above inclusion criteria

Keywords: rectal cancer wait and watch scrt lcrt
intervention for caregivers of patients undergoing hsct or car t-cell therapy

Conditions: Blood Cancer

Summary: the purpose of this study is to determine which of two approaches is helpful to support caregivers of patients undergoing hematopoietic stem cell transplant (hsct) or chimeric antigen receptors (car) t-cell therapy at seidman cancer center. this study will take start before you begin treatment until 2 months after your hospital discharge.

this is a two-group, randomized pilot study to test the feasibility, acceptability, usability, satisfaction and preliminary efficacy of a behavioral (psychoeducation) intervention, as compared to a usual care (information from healthcare providers) control group, on caregiver outcomes. the control and intervention groups will receive the standard university hospitals seidman cancer center (scc) binder of relevant information regarding care of the patient undergoing hsct or car t-cell therapy. this information will be given to the caregiver by the health care provider. in addition, the intervention group will receive 6 individual sessions with an interventionist during all phases of hsct or car t-cell therapy. the independent variable is group assignment. the primary objective of this study is to explore the feasibility and acceptability of a psycho-educational intervention designed for caregivers of patients receiving hsct (allogenic or autologous) or car t-cell therapy. the secondary objective of this study is to explore the usability, satisfaction and preliminary efficacy of a psycho-educational intervention designed for caregivers of patients receiving hsct (allogenic or autologous) or car t-cell therapy.

Eligibility criteria:
inclusion criteria: * patients: * has a diagnosis of blood cancer (leukemia, lymphoma, myeloma, mds, mpn, cml, cmml) and is scheduled to undergo hcst or car t-cell therapy at scc * will receive hsct or car t-cell therapy and follow-up care from a medical oncologist at university hospitals seidman cancer center (scc) * has english as their primary language * provides consent for his/her own treatment and procedures * has an identified caregiver (per scc-hsct and car t-cell therapy protocol) who will be involved in the patient's care post-hcst or car t-cell therapy * caregivers * an adult family or friend (at least 18 years old) of a patient scheduled to receive hsct or car t-cell therapy at scc * identifies himself/herself as the caregiver who will be responsible for the patient's care post-hsct or car t-cell therapy * has english as their primary language * is capable of providing informed consent
peri-implant marginal bone loss and implant failure in patients with smoking habit

Conditions: Dental Implant Failed; Marginal Bone Loss; Smoking

Summary: the impact of smoking on dental implant failure has been a constant topic of discussion for the past decade and the current literature confronts the inconclusive evidence of tobacco for a marginal bone loss risk factor. the aim of the present investigation is to determine the association between tobacco and marginal bone loss or implant failure in a sample of patients who had received implant-supported restorative therapy in the dentistry hospital of the university of barcelona (campus of bellvitge). considering that peri-implant marginal bone is essential for dental implant success, in this study we would like to establish the relationship between marginal bone loss around implants and smoking, in our own population study, in order to improve the prognosis of implant success in smoking patients. on the other hand, knowing the negative effect tobacco has on marginal bone loss in dental implants, we will be able to better predict peri-implant bone loss and reveal the probability of implant failure in short and long-term in smokers. by informing the patient correctly, we can raise awareness and create an additional reason for them to stop smoking, or at least reduce the number of cigarettes they smoke per day.

the present study was designed as a retrospective case control study in a sample of patients with implant-supported restorative therapy conducted at the dentistry hospital of the university of barcelona (campus of bellvitge). it is designed following the principles outlined in the declaration of helsinki (revised, amended, and clarified in 2013). all of the patients are being properly informed about the study according to the comité ético (ceic) del hospital odontològic universitat de barcelona guidelines, and informed consent must be signed prior to the interventions. patients provided with implant-supported restorative therapy were selected from the dhub database. the sample is divided in two groups: smoking and non-smoking patients. an initial questionnaire is being conducted to obtain information regarding smoking habits. candidates undergo an oral examination, radiographic study (orthopantomography and implant periapical radiograph) and implant probing to determine their peri-implant status.

Eligibility criteria:
inclusion criteria: 1. patients with a smoking habit 2. patients 20 - 80 years old 3. patients rehabilitated at dhub 4. patients with a radiographic record at the time of implant loading 5. patients rehabilitated with one or more dental implants exclusion criteria: 1. patients with untreated periodontal disease 2. patients with uncontrolled systemic pathology 3. pregnant women or in lactation 4. patients treated with antiresorptive drugs 5. patients without radiographic records

Keywords: dental implant
naturally banded versus synthetic banding of sleeve gastrectomy

Conditions: Obesity, Morbid

Summary: to compare banding sleeve gastrectomy using silicone ring versus using natural flap ( round ligament of the liver)

to compare banding sleeve gastrectomy using silicone ring versus using natural flap ( round ligament of the liver) as regard weight loss, complications rat and cost

Eligibility criteria:
inclusion criteria: * obese patients with bmi more than 40 with or without co-morbidity or more than 35 with co-morbidity * patients fit for laparoscopic surgery * give approval to share in the study exclusion criteria: * patients refused to share in the study * patients unfit for surgery * patients aged less than 18 and older than 65 * patient with previous upper abdominal surgery either for obesity or other diseases * revisional bariatric procedures
premedication with alprazolam and midazolam for upper gastrointestinal endoscopy

Conditions: Diagnostic Esophagogastroduodenoscopy

Summary: diagnostic upper gi endoscopy can be uncomfortable and stressful for many patients. various methods are available for sedation during this procedure. because of some side effects related to intravenous administration of sedatives, oral administration of these drugs is under attention. alprazolam is a benzodiazepine which is used mainly in treatment of anxiety. intravenous midazolam is being used by some centers for sedation during endoscopy, but the oral form can also be used with probably same efficacy. hence, investigators compare the efficacy/safety of oral midazolam and sublingual alprazolam as for sedation during this procedure. investigators hypothesize that sublingual alprazolam is as effective as oral midazolam in reducing anxiety and pain/discomfort related to the procedure.


Eligibility criteria:
inclusion criteria: * referring for upper gi endoscopy * age 18 to 65 years * first experience of upper gi endoscopy * class i or ii of american anesthesiology association * willingness to participate exclusion criteria: * severe psychiatric, neurological, cardio-vascular, or renal disorders * history of allergy or intolerance to benzodiazepines or lidocaine * history of upper gi surgery * pregnancy or lactation * gi anomalia during endoscopy * need for therapeutic procedures during endoscopy * active bleeding
validation of a short questionnaire (ssi) for sleep disorders in patients with alcohol

Conditions: Alcohol Dependence; Sleep Disorder

Summary: sleep disorders are very common in alcohol patients (40-90% according to studies) these sleep disorders may persist after withdrawal and represent a major factor in relapse. in a previous study, the investigators validated a simple sleep questionnaire (the "short sleep index = ssi") from a multicentre series of 602 american patients (perney et al., alcohol alcohol 2012) the ssi is obtained from the hamilton score (baseline score for anxiety and depression)

to compare the ssi with a reference sleep questionnaire (pittsburg quality sleep index) in alcohol patients in different situations: ambulatory or hospitalization

Eligibility criteria:
inclusion criteria sick people with alcohol abuse or dependence inpatient or outpatient follow-up (nîmes university hospital, grau du roi hospital, montpellier, centre de soins d'accompagnement et de prévention en addictologie (csapa of nîmes university hospital) agreeing to answer the questionnaire not having a cognitive deficit or psychiatric pathology that makes interrogation unreliable * exclusion criteria : na