Kornimate/medical-research-clean huggingface dataset:
prospective feasibility trial of accucath 2.25" blood control (bc) placed in difficult access patients in the emergency department

Conditions: Vascular Access Complication

Summary: study objective is to evaluate user preference, time for procedure, insertion success rates, complications, completion of therapy and dwell time of the accucath 2.25" bc device placed in difficult iv access patients in the emergency department.

a one arm, prospective feasibility study using the accucath 2.25" bc intravascular catheter system placed in the upper arm with ultrasound guidance, and the lower arm with and without ultrasound guidance based on clinical assessment. subjects will be subjected to a maximum of 4 attempts. if unsuccessful by the 4th attempt, alternatives will be considered as per current standard of care. currently multiple iv attempts are made in difficult iv access patients without success. patients are often escalated to more invasive lines due to the need for longer catheters without clinical indication. the study will evaluate the feasibility of accucath 2.25" bc as a low risk, lower cost alternative for this patient population in lieu of using a midline, peripherally inserted central line or central venous catheter when not clinically required for purposes of therapy.

Eligibility criteria:
inclusion criteria: 1. male or female, age \> 18 years old; 2. capable and willing to give informed consent; 3. english speaking; 4. acceptable candidate for an elective, non-emergent peripheral iv as determined by ordering physician; 5. admitted to inpatient area for minimum of 24 hours, preferably for average hospital length of stay; 6. difficult venous access patient as defined by either 2 failed initial attempts without ultrasound guidance or a history of difficult access plus the inability to directly visualize or palpate a target vein. exclusion criteria: 1. male or female, \< 18 years old; 2. requirement for emergent iv placement (patient's condition would be compromised if there is a delay in iv placement); 3. previous venous grafts or surgery at the target vessel access site; 4. subjects with lymphedema or status-post mastectomy on affected side; 5. currently involved in other investigational clinical trials (unless permission is granted by other study pi).

Keywords: difficult iv access accucath iv outcomes patient satisfaction
emergency department patient satisfaction survey in the imam reza hospital , tabriz ,iran, 2008

Conditions: Community Sample

Summary: the investigators want to survey emergency department patient satisfaction in the imam reza hospital ,tabriz ,iran by questionnaire form . finally the investigators want to improve the quality services in the department based on the research result.


Eligibility criteria:
inclusion criteria: * all patients admitted to emergency department exclusion criteria: * patients didn't sign consent form

Keywords: patient satisfaction
framing messages for smoking cessation with bupropion - 6

Conditions: Tobacco Use Disorder

Summary: this is a randomized study of message framing in individuals beginning a smoking cessation program utilizing bupropion sr and brief counseling, videos, and pamphlets.


Eligibility criteria:
exclusion criteria: * pregnant or nursing women, or women of child-bearing potential who are not using an adequate method of contraception * psychiatric illnesses requiring psychotropic medications (i.e., psychosis, major depression, mania), or the presence of suicidality or homocidality * current use of nicotine replacement therapies (i.e., nicotine patch, gum, or lozenges, nasal spray, or inhaler), bupropion (zyban, wellbutrin), or marijuana or current participation in another smoking cessation treatment * presence of unstable medical conditions (i.e., cardiac, hepatic, renal disease, diabetes mellitus) that would make a trial of bupropion sr hazardous * have taken monoamine oxidase inhibitors or metoprolol succinate within the past six weeks * history of anorexia nervosa or bulimia * previous hypersensitivity to bupropion * history of alcohol or other drug dependence in the past one year * history of seizure disorder of any etiology (i.e., brain tumor, traumatic brain injury, substance-induced seizures, etc.) * any finding that in the view of the principal investigator would compromise the subject's ability to fulfill the protocol visit schedule and visit requirements or put the subject at risk * sharing home or work environment with current or past participant * no couples or participants who see each other every day
auricular acupressure in prehabilitation

Conditions: Frailty; Thoracic; Prehabilitation; Lung Surgery; Wedge Resection; Segmentectomy; Lobectomy; Pneumonectomy; Status

Summary: complementary medicine is recognized for its ability to enhance appetite, increase energy, reduce anxiety, decrease pain, and improve sleep, among many other benefits. acupuncture is among the most frequent types of complementary medicine practiced in the us, and medicare currently includes back pain as a reimbursable indication for this therapy. acupuncture-related therapies may enhance efforts at prehabilitation in candidates for major lung resection.

the plan is to use a small number of points for auricular acupressure that are selected to improve overall health, both physical and mental. auricular acupuncture for management of pain using 5 points, informally referred to as "battlefield acupuncture" has demonstrated significant improvement in acute and chronic pain management. auricular acupressure using a similarly small number of points has demonstrated improvement in chemotherapy-related disturbed sleep, fatigue, and appetite, postpartum depression and fatigue, and chemotherapy related fatigue and depression. it appears that auricular acupressure may be suitable for enhancing prehabilitation interventions for preoperative patients. patients will be selected from among individuals being considered for major lung surgery (wedge resection, segmentectomy, lobectomy, bilobectomy, or pneumonectomy; open or minimally invasive) who are expected to pursue a period of prehabilitation of 2 or more weeks prior to surgery.

Eligibility criteria:
inclusion criteria * being considered for major lung surgery * surgery is not scheduled for at least 2 weeks * age ≥ 50 years * able to understand english at a 4th grade level * no known contraindications to prehabilitation (strength, endurance, balance exercises) * able to provide informed consent for participation * has an adult care partner who will be available and capable of placing seeds * has access to smart phone for communication and image sharing * underwent frailty screening (given any score) * able to perform spirometry testing in clinic exclusion criteria: * allergy to vaccaria seeds * medical condition affecting either ear preventing use of auricular acupressure such as eczema, frostbite, sunburn

Keywords: accupressure vaccaria seeds
a simple walking program to enhance concurrent chemoradiotherapy delivery

Conditions: Brain Cancer; Head and Neck Cancer; Lung Cancer; Gastrointestinal Cancer; Cervical Cancer

Summary: by utilizing fitness trackers, this study aims to demonstrate that a simple walking program improves patients' ability to tolerate curative concurrent chemoradiotherapy without treatment interruption.

patients will be given a commercially available fitness tracker to wear continuously throughout the course of the study. per this study's inclusion criteria, all patients will be treated with concurrent chemoradiotherapy for a malignancy of the brain, head and neck region, lung, gastrointestinal tract, or cervix. patients will be randomized to one of two arms: an experimental arm, where they will be instructed to meet a daily, customized step count goal, or a control arm where they will wear activity trackers but be given no specific instructions to increase their activity levels. patients in the experimental arm who fail to meet their step count goal for three consecutive days will be contacted by a study coordinator and reminded to try to meet the activity goals. if the patient reports that his or her activity is limited by treatment-related toxicities, the patient's treating physicians will be notified to ensure that supportive care needs are being met. with such a program, this study aims to demonstrate the potential to improve patients' ability to tolerate curative concurrent chemoradiotherapy without treatment interruption.

Eligibility criteria:
inclusion criteria: * age \> 18 * ecog performance status 0-2 * able to ambulate independently (without the assistance of a cane or walker) * diagnosis of invasive malignancy of the brain, head and neck region, lung, gastrointestinal tract, or uterine cervix * planned treatment with fractionated (≥15 treatments) external beam radiotherapy with concurrent chemotherapy (or cetuximab) with curative intent (including preoperative or postoperative treatment) * women of childbearing potential must: * have a negative serum or urine pregnancy test within 72 hours prior to the start of study therapy * agree to utilize an adequate method of contraception throughout treatment and for at least 4 weeks after study therapy is completed * be advised of the importance of avoiding pregnancy during trial participation and the potential risks of an unintentional pregnancy. * all patients must sign study specific informed consent prior to study entry.

Keywords: fitness tracker activity monitoring chemotherapy radiation therapy chemoradiotherapy
physiologic growth hormone effects in hiv lipodystrophy

Conditions: AIDS; HIV Infections

Summary: this study will investigate long-term, low-dose growth hormone administration in hiv-infected patients with reduced growth hormone (gh) secretion and increased visceral adiposity. we hypothesize that low-dose growth hormone will reduce visceral fat. secondary endpoints will include measures of insulin-like growth factor-1 (igf-1), glucose homeostasis, lipids, blood pressure,bone density, cardiovascular risk and safety parameters.

this study will investigate long-term, low-dose growth hormone administration in hiv-infected patients with reduced growth hormone (gh) secretion and increased visceral adiposity. we hypothesize that low-dose growth hormone will reduce visceral fat preferentially over subcutaneous fat, and increase lean body mass. secondary endpoints will include measures of igf-1, glucose homeostasis, lipids, blood pressure,bone density, cardiovascular risk and safety parameters. dosing of growth hormone will be based on patients' igf-1 levels and will not exceed 6mcg/kg/day.

Eligibility criteria:
inclusion criteria: * men and women age 18-60 * previously diagnosed hiv infection * stable antiviral regimen for at least 12 weeks prior to enrollment * waist-to-hip ratio \>0.90 for men and \>0.85 for women * evidence of at least one of the following recent changes: \*increased abdominal girth, \*relative loss of fat in the extremities, \*relative loss of fat in the face * simulated peak gh response to arginine/ghrh of less than 7.5 mcg/dl exclusion criteria: * use of megace, anti-diabetic agents, gh, or other anabolic agents, pharmacologic glucocorticoid (prednisone \>5 mg/day or its equivalent) for 3 months prior to enrollment. patients on a standard dose of testosterone for documented hypogonadism will be allowed to enter the protocol. women taking standard estrogen replacement therapy for \>3 months will be allowed in the study. * diabetes mellitus * other severe chronic illness * hgb \ 1.4 mg/dl, or psa \>4 ng/ml * positive bhcg or failure to use appropriate birth control during study. acceptable methods include oral contraceptives, depo provera or combined progesterone-estrogen injections, transdermal contraceptive patches, iud's, barrier devices (condoms, diaphragms), and abstinence. * carpal tunnel syndrome * active malignancy or history of pituitary malignancy, history of colon cancer or prostate malignancy

Keywords: hiv lipodystrophy growth hormone visceral fat igf-i treatment experienced
mandibular fracture reduction using bone reduction forceps

Conditions: Mandibular Fractures

Summary: different methods have been used in reducing mandibular fractures. bone reduction forceps provides precise reduction and stabilize mandibular fracture segments.

the aim of this study is to evaluate clinically and radiographically the effect of using bone reduction forceps in the reduction of isolated mandibular fractures. 10 patients complaining of isolated mandibular fractures in need of open reduction and internal fixation underwent reduction using bone reduction forceps. the patients followed up clinically after 1 and 2 weeks, 1, 3, and 6 months postoperatively. radiographic evaluation will be performed by computed tomography (ct) preoperatively, and cone-beam computed tomography (cbct) will be done after 3 and 6 months

Eligibility criteria:
inclusion criteria * adult patients aged from 20 to 45 years will be included. * patients suffered from recent and uninfected. * patients with isolated mandibular fractures. exclusion criteria * medically compromised patients that will be not fit for surgery. * edentulous patients. * non-displaced * comminuted fracture with bone loss * old fracture, more than 3 weeks
in-home adjustment of new spinal cord injury caregivers

Conditions: Spinal Cord Injuries

Summary: to improve spinal cord injury (sci) rehabilitation through stronger informal caregiving, the proposed study will modify and evaluate a telehealth transition assistance program (tap) for informal caregivers of individuals with sci during the transition from hospital to home. the tap was previously developed for stroke caregivers and has been found to decrease caregiver strain and depression. in the proposed study, the tap will be modified for sci and implemented at a state-of-the-art sci rehabilitation facility with a very high volume of sci treatment and with telehealth technology already in place through which to test the intervention.

sci caregivers will be randomly assigned to either the tap group or to a control receiving the standard care provided by the rehabilitation facility. the tap begins before discharge and extends across six weeks. it includes three components to improve caregiver mental health and informal care: (1) skill development, (2) education, and (3) supportive problem solving. tap caregivers will receive an sci caregiving guidebook, a 1-hour intervention session by an sci clinician before hospital discharge, and four 1-hour telehealth clinic-to-home visits at 1, 2, 4, and 6 weeks after discharge by the same clinician. data will be collected from caregivers and individuals with sci at baseline immediately before discharge and at 2 and 4 months after discharge.

Eligibility criteria:
inclusion criteria: sci patient inclusion criteria: * have a telephone in the home or cellular phone and are able to talk on the phone in english * are able to provide informed consent * demonstrate a clinician-rated loss in motor/sensory function on the asia scale (i.e., have a spinal cord injury) caregiver inclusion criteria: * have a telephone in the home or cellular phone and are able to talk on the phone in english * are able to provide informed consent * are a primary caregiver of the individual with sci * caregivers with scores below 10 on the literacy screen will identify a family member or friend to review the guidebook with the caregiver. if no one is identified, the tap clinician will review the materials with the caregiver and function in that additional capacity exclusion criteria: * individual with sci receives his/her primary care from a professional caregiver or other individual outside of the household besides the primary caregiver * individuals with sci or caregivers with known current uncontrolled substance dependence, aphasia, anosognosia (deficit in self-awareness), or treatment due to known self-inflicted injury * individuals living alone * prisoners * sci patient without decision making capacity to consent
the pk characteristics of the co-administration of metformin sr and rosuvastatin and jlp-1310 in healthy male volunteers

Conditions: Diabetes; Hyperlipidemia

Summary: a randomized, open-label, single dose, crossover study to compare the pharmacokinetic characteristics of the co-administration of metformin sr and rosuvastatin and jlp-1310 in healthy male volunteers

a randomized, open-label, single dose, crossover clinical trial

Eligibility criteria:
inclusion criteria: * healthy male volunteer, age is over 19 years body weight is over 55kg, the result of body mass index(bmi) is not less than 17.5 kg/m2 , no more than 30.5 kg/m2 * subject who has the ability to comprehend the study objectives, contents and the property of the study drug before participating in the trial * subject who has the ability and willingness to participate the whole period of trial exclusion criteria: * presence of medical history or a concurrent disease that may interfere with treatment and safety assessment or completion of this clinical study, including clinically significant disorders in kidney, liver, cardiovascular system, respiratory system, endocrine system, or neuropsychiatric system. * subjects who are allergic to investigational drug. * subjects who have a medical history which can affect the clinical trial. * systolic bp \> 140mmhg or diastolic bp \> 90mmhg) * ast or alt \> x 2 unl * history of drug abuse or positive drug screening. * participation in other drug studies within 3 months prior to the drug administration. * whole blood donation within 60 days, blood component donation within 30 days or who got transfusion within 30days.
impact of a comprehensive cardiac rehabilitation program framework among high cardiovascular risk cancer survivors

Conditions: Oncologic Disorders; Cardiovascular Diseases

Summary: many cancer survivors are at risk for cardiovascular disease (cvd); it is therefore important to identify patients at increased risk for cardiotoxicity, especially in the setting of cvrf or pre-existing cvd, and to design personalized interventions to prevent cardiovascular morbidity. in this background, cardio-oncology rehabilitation frameworks for specific cancer patients have been proposed. given potential beneficial effects of exercise among cancer patients (including those at higher risk of cvd), data pertaining to optimal program designs are of paramount contemporary importance. thus, the aim of this study is to compare the impact of a cardiac rehabilitation program (crp) model versus a community-based exercise intervention plus usual care on cardiorespiratory fitness (crf), physical function domains and cvrf control in adult cancer survivors who have been exposed to cardiotoxic cancer treatment and/or with cardiovascular medical background. study outcomes will be assessed at baseline (m0) and after an 8 weeks-intervention (m1), comprising maximal aerobic capacity (peak oxygen uptake), muscular strength, neuromuscular function, single cvrf control including physical activity measurements and psychosocial parameters, health-related quality of life, fatigue, health literacy, inflammatory response and feasibility metrics; an economic evaluation will provide quantitative comparison, for a cost-effectiveness analysis


Eligibility criteria:
inclusion criteria: * age \>18 years * cancer survivors exposed to the following therapies: * high-dose anthracycline or high dose radiotherapy in thoracic wall * low-dose anthracycline or anti-human epidermal growth factor receptor-type 2 drugs (anti-her2) alone plus ≥ 2 cvrf and / or age ≥ 60 years at cancer treatment * low-dose anthracycline followed by anti-her2; * cancer survivors with medical background of * coronary artery disease * moderate valvular disease * lvef \<50% * follow up after primary treatment with curative intent * conclusion of primary treatment at least 2 months before the inclusion exclusion criteria: * previous participation in a crp * contraindications to exercise training: * musculoskeletal or neurologic disorders, cognitive impairment * unstable angor pectoris, decompensated hf, active myocarditis, acute endocarditis, acute pulmonary thromboembolism, complex ventricular arrhythmias * active cancer * considered unsuitable as per principal investigator judgment (namely due to expected inability to fulfill proposed schedule)

Keywords: cardiac rehabilitation cardio-oncology rehabilitation exercise training cardiorespiratory fitness cardiovascular risk factors
study on predictiors and mechanism of conversion to psychosis in individuals at ultra-high risk group

Conditions: Schizophrenia

Summary: considering the complex pathological mechanism and the poor treatment outcomes of schizophrenia, early detection and intervention gradually become the key work for the foundational and clinical research in schizophrenia. ultra-high risk for psychosis (uhp) is defined as individuals at the prodromal stage of schizophrenia. early intervention in individual at uhp can effectively delay or even prevent the development of the illness. long-term longitudinal studies suggested that there are clinical outcomes in people at uhp. nearly 1/3 of individuals at uhp may be naturally relieved without any intervention, about 1/3 of individuals at uhp will remain at the prodromal stage of schizophrenia, and only 1/3 individuals at uhp will eventually develop schizophrenia. in this regard, it will cause adverse effects on false positive individuals if they accept clinical intervention. unfortunately, it is difficult to accurately predict which individuals at uhp will make a transition to frank illness. to solve this issue, we explore the association between baseline brain structural and functional networks, methylation modifications, gene expression, neurocognitive function and the clinical outcomes of uhp individuals, and to identify the potential biological and clinical predictors for the long-term outcomes in the individuals at uhp. in addition, we also detect the changes of brain structure and function, methylation status and gene expression in individuals at uhp during follow-up, and further to investigate the etiology and pathogenesis of schizophrenia.


Eligibility criteria:
inclusion criteria: * 1. age of 13-30 years; * 2. meet the diagnostic criteria of cops prodromal syndrome by sips clinical interviews; * 3. have not received any psychiatric medication; * 4. be in good health, without major mental illness or physical illness; * 5. normal intelligence, can be operated on a clinical scale; * 6. volunteer to participate in the study and sign the written consent form. exclusion criteria: * 1. exclusion of current or previous psychiatric disorders by scid interview; * 2. meet the diagnostic criteria for substance abuse and substance dependence in dsm-iv; * 3. contraindications for mri; * 4. pregnant or lactating women.

Keywords: schizophrenia; ultra-high risk for psychosis; predictors; pathogenesis