Kornimate/medical-research-clean huggingface dataset:
rest easy: is bed rest really necessary after surgical repair of an ankle fracture?

Conditions: Ankle Injuries; Fracture

Summary: after a patient has fractured an ankle that then requires surgery, the recommendation is to remain in bed, with the operated leg elevated on pillows for 48 hours. this is a precautionary measure, as yet unsubstantiated by research, which is thought to minimize ankle swelling that can inhibit the healing of the surgical wound. however, prolonged bed rest can lead to other complications such as blood clots in the lungs or leg veins, or chest infections such as pneumonia. prolonged bed rest is also known to cause weakness and a loss of fitness such that recovery may be slower. in this research the investigators will be randomly allocating patients to mobilize within 24 hours post operatively or to rest in bed for 48 hours with their leg well elevated. the investigators will measure length of stay and wound healing and integrity at 14 days. this study aims to investigate whether getting patients out of bed within 24 hours of surgery can accelerate recovery and reduce acute hospital length of stay without affecting wound healing. if bed rest for 2 days is not necessary, there will be benefits for the patient in terms of general health and ability, and for the hospital in terms of cost savings through shorter lengths of stay and patient through put. the investigators already know that early mobilization is beneficial following other types of orthopedic surgery such as hip fractures. this study aims to investigate if early mobilization following surgical management of ankle fractures is safe with specific regard to wound integrity and wound outcomes. this study will also investigate the effect of earlier mobilization on the length of time spent in the acute hospital and for those discharged directly home, the amount and type of support required. if early mobilization is found to be safe for wound healing and results in shorter in-hospital stays, this research will provide the confidence to endorse a change to current clinical practice.


Eligibility criteria:
inclusion criteria: * patients who have had internal fixation of a fractured ankle closed without plastic surgery intervention and without follow up hyperbaric oxygen therapy exclusion criteria: * living in nursing home, * previously non-ambulant, * concommitant injuries which do not allow early mobilisation, plastics involvement for wound closure, hyperbaric oxygen therapy

Keywords: ankle fracture mobilisation bed rest internal fixation
predisposition to persistent pain after orthopaedic surgery: genetic aspects

Conditions: Chronic Pain

Summary: the study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and adrb2 polymorphism in orthopaedic surgery. the primary aim is to evaluate the expression of adbr2 in vas\>4 patients and to compare it to those with vas\<4.


Eligibility criteria:
inclusion criteria: * age \> 18 * asa i to iii exclusion criteria: * contraindications to regional anesthesia procedures * not stabilized neurological diseases * diabetes
effect of tobacco heating system (ths) on closed lower limb fracture healing

Conditions: Smoking; Tibia Fracture

Summary: the goal of this clinical trial is to investigate the role of switching from cigarette smoking (cs) to tobacco heat system (ths) on the clinical outcome of closed lower limb (tibia and femur) fractures from smokers' orthopedic patients. validated and standardized assays, medical state and self-reported outcomes will be evaluated in orthopedic patients' smokers or switch from cs to using ths throughout six months compare to ex-smokers (control).


Eligibility criteria:
inclusion criteria: * closed tibia or femur fracture (according to ao/ota: 41a2-41c3, 42a-c, 43a-c, 32a-c, 33a2-3, 33b-c) which is surgically treated within 14 days after the trauma at the bg trauma clinic tübingen. additional inclusion criteria for the smoking and ths groups: * smokers with 10-20 packyears smoking history. * smoking history \>10 years. * decision not to participate in the free smoking cessation seminars. exclusion criteria: * legal guardian or loss of capacity to consent. * refusal to participate in the study. * open fractures or concomitant injuries or complications requiring surgery existing at the time of surgical indication. * initial surgical treatment of the fracture has occurred ex domo. * no initial surgical treatment within 14 days of sustained trauma. * using nicotine delivery electronic devices. * pre-existing autoimmune, immunological, bone or malignant diseases. * pregnant, breastfeeding and women of childbearing age with existing desire to have children. * history of alcohol abuse or drug abuse. * taking antioxidants approval by the german federal institute for drugs and medical devices (bfarm). * taking drugs with known effect on bone metabolism (according to institute for medical and pharmaceutical examination issues (impp): allosteric casr modulators, bisphosphonates, calcium release inhibitors, alkaline earth ions, rankl inhibitors, calcitriol, colecalciferol).

Keywords: bone healing tobacco heating system smoking cessation
holep prior to radiation therapy for patients with luts/retention and concurrent prostate cancer

Conditions: Prostate Cancer; Lower Urinary Tract Symptoms

Summary: to determine if holmium laser enucleation of the prostate (holep) for the treatment of lower urinary tract symptoms (luts) and/or urinary retention alters the treatment course for patients concurrently diagnosed with prostate cancer.

the investigators propose a prospective trial to investigate pre-radiation holmium laser enucleation (holep) in men with bothersome lower urinary tract symptoms (luts) and prostate cancer who have elected for radiation therapy as the primary treatment modality for their prostate cancer. the investigators hypothesize that pre-radiation holep may decrease their overall luts and may decrease their need for subsequent radiation therapy. the goal with this study is to better understand the overlap between prostate cancer and luts, as well as determine if primary surgical treatment for the luts with holep can also serve as a possible treatment modality for concurrent prostate cancer. this information may provide further information to inform future standard of care practices for patients with prostate cancer.

Eligibility criteria:
inclusion criteria: * patients must be 18 years of age or older * patients must have bothersome lower urinary tract symptoms (luts), defined by american urological association symptom score (aua ss) of greater than or equal to 15 and/or as defined by a post-void residual of greater than or equal to 350ml and/or as defined by catheter dependence * patients must be diagnosed with prostate cancer by pathological tissue analysis * patients must have elected for radiation with androgen deprivation therapy as the primary treatment modality for their prostate cancer exclusion criteria: * patients who are under 18 years of age are not eligible * patients who have a diagnosis of bladder cancer are not eligible. * patients with prior treatment for prostate cancer are not eligible. * patients with any type of prior prostate surgery (minimally invasive, endoscopic, or otherwise) including prior transurethral resection of the prostate (but excluding prior prostate biopsy) are ineligible. * patients with known metastatic prostate cancer are ineligible * patients who are enrolled in other surgical or international trials at the time of this study are not eligible
effect of procedural variables on outcome of surgical treatment of vitiligo

Conditions: Vitiligo

Summary: orshfs grafts yielded lower cell counts than ncecs but the m-k ratio and resultant repigmentation did not show significant difference with better healing of the donor site. compared to cryoblebs, co2 gave more homogenous pigmentation. the acral sites showed better results using combination of donor ncecs and recipient cryoblebs.

background: melanocyte-keratinocyte suspension (m-k susp) is gaining popularity for vitiligo treatment. few studies have addressed procedure-related variables. objective: to assess the effect of different m-k susp procedure-related variables on the clinical outcome in stable vitiligo. methods: this retrospective study included 40 cases with stable non-segmental vitiligo treated by m-k susp followed by narrow band- ultraviolet b phototherapy twice weekly. donor site was either a skin graft in non-cultured epidermal cell suspension (ncecs) (34 cases) or hair follicle unit in outer root sheath hair follicle suspension (orshfs) (6 cases). recipient site was prepared by either cryoblebbing (24 cases) or carbon dioxide (co2)laser resurfacing (16 cases). cell counts and viability were recorded in the cell suspensions, and tissue melanocytes and keratinocytes were examined by melan a and cytokeratin respectively. assessment of repigmentation was done 18 months after the procedure.

Eligibility criteria:
inclusion criteria: * stable non-segmental vitiligo exclusion criteria: * active vitiligo

Keywords: : non-segmental vitiligo melanocyte-keratinocyte suspension cryoblebbing co2 laser
awareness of osteoporosis in multiple sclerosis patients

Conditions: Multiple Sclerosis; Osteoporosis; Osteoporosis Risk

Summary: osteoporosis is a condition that describes compromised skeletal microarchitecture in general, with clinical signs of decreased bone mineral density. multiple sclerosis patients are at increased risk for developing osteoporosis. identifying whether multiple sclerosis patients have information and awareness about this disease is crucial. this study is aimed to investigate awareness and knowledge of osteoporosis in multiple sclerosis (ms) patients. the study also aimed to assess potential differences and correlations in osteoporosis knowledge and awareness among ms patients based on gender, education levels, and risk of falls

osteoporosis is a common disease of bone loss. the reduced bone strength predisposes an increased risk for fractures in older individuals. it can affect people from different ethnicity. many factors increase the risk of osteoporosis, including age, postmenopausal state, glucocorticoid use, low body weight, calcium, vitamin d, immobility, and chronic inflammation. patients with multiple sclerosis are at high risk of developing osteoporosis due to chronic inflammation and their medications. patients' knowledge and awareness about osteoporosis are essential for early detection, implementation of lifestyle changes, and treatment compliance. this study aimed to investigate osteoporosis awareness and knowledge about osteoporosis in patients with multiple sclerosis.the study also aimed to assess potential differences and correlations in osteoporosis knowledge and awareness among ms patients based on gender, education levels, and risk of falls

Eligibility criteria:
inclusion criteria: * clinical diagnosis of multiple sclerosis * must be between the ages of 18 and 99 * must give consent to participate in the study exclusion criteria: • not giving consent
phase iib rheumatoid arthritis dose ranging study for bms-945429 in subjects who are not responding to methotrexate

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to determine the effective dose of bms-945429 in subjects with inadequate response to methotrexate in the treatment of moderate to severe rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: * inadequate response to methotrexate * must have been taking methotrexate for at least 3 months at a minimal weekly dose of at least 15 mg and stable dose for 4 weeks prior to randomization * american college of rheumatology (acr) global function status class 1-3 * minimum of 6 swollen and 6 tender joints with evidence of synovitis in at least 1 hand or wrist * high sensitivity c-reactive protein (hscrp) ≥ 0.8 mg/dl exclusion criteria: * previously received or currently receiving concomitant biologic therapy
effect of smartphone application (med-ad) on medication adherence among patients with cardiovascular disease in oman

Conditions: Ischemic Cardiovascular Disease; Hypertension; Hyperlipidemia

Summary: this study aims to: 1. investigate the impact of med-ad intervention on medication adherence among cvd patients, compared to patients receiving text message reminders or routine care alone at baseline, 6 months, and 12 months later. 2. evaluate the effectiveness of med-ad intervention on clinical outcomes among patients with cvd, compared to the outcomes of patients receiving text or routine care alone at baseline, 6 months, and 12 months later. this study is a prospective randomized controlled clinical trial (rct) with three arms: 1. med-ad intervention: med-ad is a smartphone application that will use the following strategies (pill reminders, medication adherence report, medication intake confirmation, medical appointment reminder, and educational notifications) to enhance medication adherence 2. text message reminders: participants will receive short text message (sms) reminders to remind them to take medications as prescribed once daily 3. routine care only: participants will receive routine care that does not include text messages or reminders and education through an application.


Eligibility criteria:
inclusion criteria: 1. diagnosed with at least one cvd (i.e., htn, ihd, hyperlipidemia), 2. prescribed at least one medication for at least one year, 3. omanis aged 18 years or older, 4. registered in the selected healthcare center, and 5) agreed to participate in the study exclusion criteria: 1. have a severe cognitive impairment, 2. are unable to provide informed consent, 3. cannot read, and 4) do not have a smartphone with a compatible operating system (ios or android).
acute myeloid leukemia and markers of leukemia stem cells (cll1 and cd45ra)

Conditions: Acute Myeloid Leukemia

Summary: acute myeloid leukemia (aml) is a malignant disorder of the bone marrow and the most common form of acute leukemia in adults. patient with aml have the shortest survival compared to other forms of leukemia. in the past 6 years, several new therapies have been approved. biomarkers are in urgent need to guide therapeutic regimen selection in order to maximize the benefit of available therapies and minimize treatment toxicity. current standard practice is to perform bone marrow biopsy at end of treatment cycle (each cycle around 28 days), and based on bone marrow finding, to decide further treatment plan. it is invasive and time consuming. in this study investigators will study whether tracking leukemia stem cells (lsc) in peripheral blood during early treatment cycle may provide a non-invasive method to predict therapeutic outcome at end of treatment cycle. a retrospective study found that lsc fractional change, defined by two lsc markers, named cll1 and cd45ra, is highly correlated with therapeutic outcome. further more, cll1 and cd45ra positive lsc fraction demonstrates a high concordance between bone marrow and peripheral blood, offering the opportunity to track cll1 and cd45ra positive lsc fraction non-invasively in peripheral blood during treatment. this pilot study will allow the investigators to decide whether testing cll1 and cd45ra positive lsc in peripheral blood during leukemia treatment is feasible in clinical practice. this result will lay the foundation for designing future trials using cll1 and cd45ra positive lsc fractional change to optimize therapeutic strategy for patients with aml.


Eligibility criteria:
inclusion criteria: * diagnosis of acute myeloid leukemia * ability to receive treatment for acute myeloid leukemia at the research center * elevated values of cll1a and cd45ra positive cells at the time of diagnosis
urokinase-type plasminogen activator receptor and gastroesophageal cancer

Conditions: Esophagus Cancer, Adenocarcinoma

Summary: the aim of this study is to investigate urokinase plasminogen activator receptor (upar) microexpression in gastroesophageal cancer (adenocarcinomas) both qualitatively and semi-quantitatively and to evaluate if it offers a possibility for future imagining purposes.

* sections of the tumor tissue will be he stained. * sections of the tumor tissue will be stained with an upar antibody for immunohistochemistry. * immunohistochemical staining against cytokeratin which colors cancer cells will be made to assist the observer in the evaluation of upar microexpression pattern. * a semiqualitative scale corresponding to the level of upar expression will be made. * quantitative polymerase chain reaction will be used to validate the immunohistochemistry upar expression pattern. * an electronic scoring system (digital pathology) will be trained to access the expression of upar in both tumor- and normal tissue.

Eligibility criteria:
inclusion criteria: * age ≥18 years old. * patients who underwent curatively intended surgery for gastroesophageal cancer * patients who underwent surgery after 01-01-2016. exclusion criteria: * patients who applied for an exception from medical research at the "national registry of tissue use." * patients with other histological subtypes than adenocarcinoma.

Keywords: urokinase plasminogen activator receptor upar cardia adenocarcinoma immunohistochemistry
effect of using myopia prediction algorithm on myopia school-aged children

Conditions: Myopia

Summary: in this study, the investigators aim to perform a prospective, randomized controlled study to compare the myopia development between myopia children using myopia prediction algorithm and myopia children without using myopia prediction algorithm

the investigators propose to enroll myopia children aged 8-10 in china. children will be given examinations of visual acuity, eye refraction and biometrics, and be assigned to two groups: participants in group a use myopia prediction algorithm to predict myopia development, while in group b, the participants do not use myopia prediction algorithm to predict myopia development. the visual acuity, eye refraction and biometrics will be investigated over the one-year follow-up period, aiming at comparison of actual myopia development between the two groups

Eligibility criteria:
inclusion criteria: * children aged 8-10 * has the record of eye refraction examined in the past year, ser\<-0.5d * current bcva≥0.8, ser\<-0.5d, astigmatism less than 1.50 d, anisometropia less than 1.50 d * written informed consents provided exclusion criteria: * definitive diagnosis of other diseases except for refractive error * previous eye surgery * previous usage of orthokeratology lenses and atropine * unwilling to participate in this trial

Keywords: vision disorders artificial intelligence myopia prediction
validity and reliability of a turkish version of md anderson inventory dysphagia inventory

Conditions: Dysphagia; Neurologic Disorder

Summary: the purpose of this study is to m.d. validity of the turkish version of the anderson dysphagia inventory for the turkish population, reliability, and cultural adaptation.

oropharyngeal dysphagia (od) is a common finding in patients with neurogenic disorders. swallowing disorder can be acute or chronic in nature. for example, acute od is observed in patients after stroke, head trauma, neurosurgical intervention, or in patients with guillain-barré syndrome. chronic od may develop in patients who do not recover after a stroke. degenerative od, parkinson's disease, amyotrophic lateral sclerosis, myasthenia gravis, huntington's disease, myotonic dystrophy type 1 and multiple sclerosis it is seen in patients with progressive neurological diseases. the prevalence of od in neurogenic patients varies from 3% to 50% in stroke patients and up to almost 100% in patients with huntington's disease. the od can lead to weight loss, malnutrition, social isolation, aspiration pneumonia, and reduced health-related quality of life (qol). some studies have reported that dysphagia-specific qol is weakly associated with od severity measured using, among other things, fiberoptic endoscopic evaluation of swallowing (fees) and videofluoroscopy of swallowing (vfs). therefore, dysphagia-specific qol questionnaires used alongside these instrumental assessments add value by providing insight into patients' perception of od, which can be taken into account in the treatment plan. there are dysphagia-specific quality-of-life questionnaires that are actively used today: swallowing quality of life questionnaire (swal-qol, 44 items), swallowing disability index (30 items), dysphagia handicap index (25 items) and m.d. anderson dysphagia inventory (mdadi, 20 items). multidisciplinary dysphagia clinics in our country mostly focus on the head and neck. it is visited by patients with od of oncological or neurological origin.the m. d. anderson dysphagia inventory is an easier inventory to perform since it has a smaller number of questions and contains more standard questions compared to other currently used questionnaires. other questionnaires, such as the swal-qol-tr and the swallowing disability index, are longer than the mdadi and take more time to complete. the purpose of this study is m.d. validity of the turkish version of the anderson dysphagia inventory for the turkish population, reliability and cultural adaptation.

Eligibility criteria:
inclusion criteria: group 1: * diagnosed with neurologic disorder * able to speak, read, understand and write in turkish * history of dysphagia during 6 months group 2: * able to speak, read, understand and write in turkish * healthy adults exclusion criteria: * mini mental state examination score below 23 points * history of head and neck cancer (hnc), * age below 18 or above 85 years.
evaluation on standardized circuits of the interest of a robotic module of assistance to the driving

Conditions: Neurological Disorder

Summary: the device that is the subject of this investigation is a robotic assistance module for driving a semi-autonomous electric wheelchair. this module is designed to accessorize the electric wheelchair to improve the safety conditions when driving an electric wheelchair, thus reducing the wheelchair accident rate on the one hand and facilitating access to the wheelchair to persons who can not claim it without the use of a safety device of this type.

the device that is the subject of this investigation is a robotic assistance module for driving a semi-autonomous electric wheelchair. this module is designed to accessorize the electric wheelchair to improve the safety conditions when driving an electric wheelchair, thus reducing the wheelchair accident rate on the one hand and facilitating access to the wheelchair to persons who can not claim it without the use of a safety device of this type. this study "swadapt2" follows "swadapt1" with patients with neurological disorders, regular drivers of electric wheelchairs, in the same conditions : each patient included will test a wheelchair equipped with a collision avoidance assistance module in 2 conditions, assistance activated or not. this evaluation will be carried out in 3 standardized test circuits of increasing difficulty, one week apart. at each session, the patient will perform the circuit 6 times, including 3 with activated assistance, in a random order established upstream.

Eligibility criteria:
inclusion criteria: * aged over 18, * having read the information note and freely consented to participate in the study, * suffering from neurological disorders such as cerebro-lesion or neuro-degeneration, * having benefited from an electric wheelchair prescription or learning to drive. * having difficulties driving an electric wheelchair impacting their indoor and/or outdoor driving safety, as shown by the wst score. * the physical measurements (weight, height) are compatible with the use of the electric wheelchair chosen for the development of the robotics assistance module. exclusion criteria: * understanding difficulties preventing the realization of the protocol, * motor disorders of the upper limb requiring additional driving technical assistance.