Kornimate/medical-research-clean huggingface dataset:
invasive techniques in trigger points

Conditions: Trigger Point Pain, Myofascial

Summary: myofascial pain syndrome (mps) is present in up to 87% of the patients that present pain. mps usually presents painful myofascial trigger points (mtrps). one methodology used to quantify the pain in mps is the algometry, which measures the pressure pain threshold (ppt). invasive techniques in physiotherapy have become popular in the last years due to their clinical efficacy and evidence. percutaneous microelectrolysis (mep®) and dry needling are techniques that are already in use for this syndrome. mep® is a technique that employs a galvanic current up to 990 microamperes, which is applied percutaneously with an acupuncture needle connected to the cathode. it is also known as low intensity percutaneous electrolysis. the aim of this study is to compare the effects in pain and muscle tone (measured with algometry and surface electromyography) of invasive techniques. healthy subjects between 18 to 48 years old, both sex, presenting mtrps in upper trapezius will be recruited. the secondary objectives are to determine the discomfort degree of each technique and if it is better to use mep® with a fixed dose or with an algorithm in which the dose varies. the hypothesis, according to our previous studies, is that mep® generates higher changes in ppt.


Eligibility criteria:
inclusion criteria: 1. neck pain during the last 6 months 2. presence of a palpable taut band in the upper trapezius 3. presence of a hypersensitive tender spot in the taut band, with local or referred pain elicitation in response to compression 4. ppt less than 3 kg/cm2 exclusion criteria: 1. previous cervical and/or shoulder surgical intervention. 2. phobia to needles. 3. temporomandibular disorders. 4. medicated with anticoagulants 5. still receiving a treatment for the myofascial trigger points (physical therapy, nsaids, etc.) 6. diagnosis of fibromyalgia. 7. radiculopathies and/or radicular pain 8. whiplash related neck pain 9. migraines 10. dizziness 11. endocrinal diseases 12. being pregnant 13. cancer

Keywords: trigger point percutaneous electrolysis physical therapy modalities
model-based cueing-as-needed for walking in parkinson's disease

Conditions: Parkinson Disease; Walking, Difficulty; Gait, Festinating

Summary: correcting of the lack of regularity in steps is a key component of gait rehabilitation in parkinson's disease. the proposal is to introduce adaptive spatial auditory cueing (asac) based on verbal instruction "lengthen the step" automatically delivered when the stride length decreased below a predetermined threshold. the present study compared the effect of usual rhythmic auditory cueing versus asac used during a walking training in parkinson's disease.

correcting of the lack of regularity in steps is a key component of gait rehabilitation in parkinson's disease. the proposal is to introduce adaptive spatial auditory cueing (asac) based on verbal instruction "lengthen the step" automatically delivered when the stride length decreased below a predetermined threshold. the present study compared the effect of usual rhythmic auditory cueing versus asac used during a walking training in parkinson's disease. fifteen patients with parkinson's disease performed both interventions in randomized order, one week apart: a 20-minute walking training with rhythmic auditory cueing, in form of a metronome adjusted on 110% of the patient's own cadence, or asac delivered when the stride length is less than 110% of the patient's own stride length. assessment criteria were walking distance covered during the intervention, speed, step length, cadence, coefficients of variation of step length and step duration, and indexes of spatial and temporal asymmetry during a walking test before and just after the intervention.

Eligibility criteria:
inclusion criteria: * the diagnosis of idiopathic pd based on the united kingdom-parkinson's disease society brain bank criteria; * stage 2 or 3 on the hoehn and yahr scale; * comfortable walking speed over 10 meters ≤ 1 m/s; * ability to walk over 20 minutes without aids or antiparkinsonian medications; * a stable antiparkinsonian medication regime; * cognitive abilities to understand the verbal instructions for a walking test according to the investigator's judgment; * written consent for the participation. exclusion criteria: * intercurrent disease other than pd, affecting gait; * any intercurrent medical condition preventing them from participating in two consecutive gait training one week apart; * medical diagnosis of hearing loss; * non-affiliation to the social security regime.

Keywords: basal ganglia diseases gait analysis gait speed cues exercise therapy
a single-center retrospective cohort study to explore the prognostic significance of conut in elderly cad patients with hfpefand compare conut with other objective nutritional indices.

Conditions: Heart Failure With Preserved Ejection Fraction; Malnutrition; Aged; Prognosis

Summary: hf is an advanced or terminal stage of various heart diseases, with high rehospitalization and mortality rates. in hf patients, undernutrition is not uncommon and represents one of the most significant determinants of poor clinical outcomes. therefore, nutritional management is of paramount importance for patients with hf.the basic method of nutritional management is to effectively identify the nutritional status of patients with heart failure, especially in elderly patients with heart failure who are not easy to find in the early stage. limited data are available regarding the association between conut score and prognosis in elder patients with hfpef, despite its easy availability in routine blood chemistry. therefore, we aimed to evaluate the prognostic significance of conut score and to compare it with other well-established nutritional indices in hfpef, a common hf phenotype in the elderly population with coronary artery disease. this was a single-center retrospective cohort study which were approved by the clinical research ethics committee of our hospital (trecky2021-185). written informed consent was obtained from all patients. participants were accorded with diagnostic criteria of cad and hfpef excluding rheumatic heart disease, congenital heart disease, acute myocardial infarction, hemodialysis or hemofiltration, tumour activity, urgent surgery, death during hospitalization, hf of unknown reasons, new york heart association(nyha) class1and data deficiency. demographic characteristics and medical parameters were collected from the electronic medical record system . all enrolled patients were followed-up in an outpatients setting. the primary endpoint of this study was readmission due to heart failure and all-cause mortality in the first year after hospitalization. to explore the prognostic significance of controlling nutritional status score in elderly with ejection fraction preserved heart failure and compare controlling nutritional status score with other objective nutritional indices.all analyses were performed using statistical product service solutions(spss) version 19.0 .


Eligibility criteria:
inclusion criteria: 1. elderly patients (≧65years old) were accorded with diagnostic criteria of coronary artery disease, hfpef and nyha ⅱ-ⅳ 2. coronary artery disease was defined 3. the diagnosis of hf was made according to the recommendations of the european society of cardiology . 4. hfpef was defined 5. severity of functional class was based on nyha scale. exclusion criteria: 1. rheumatic heart disease 2. congenital heart disease 3. acute myocardial infarction 4. hemodialysis or hemofiltration 5. tumour activity, urgent surgery 6. death during hospitalization 7. hf of unknown reasons 8. nyha classⅰ 9. data deficiency 10. loss of follow-up
ciclosporin a and acute myocardial infarction

Conditions: Myocardial Infarction

Summary: beyond its immunosuppressive properties, ciclosporine a (csa) can also inhibit the opening of a mitochondrial mega-channel called the permeability transition pore (mptp). opening of the mptp plays a key role in cardiomyocyte death during reperfusion following a prolonged ischemic insult. ciclosporin a has been shown to reduce infarct size when administered at reperfusion in experimental models. the objective of the present study is to determine whether administration of csa at reperfusion in patients with ongoing acute myocardial infarction treated by coronary angioplasty might reduce infarct size.


Eligibility criteria:
inclusion criteria: * male and female patients, aged more than 18, with suspected first acute myocardial infarction * within 12 hours of the onset of chest pain * with a need for emergency revascularization by angioplasty. patients must display a fully occluded (timi zero flow) culprit coronary artery, absence of visible collaterals and exhibit timi flow \>2 after direct stenting by angioplasty. exclusion criteria: * hypersensibility to ciclosporine a * cardiac arrest or cardiogenic shock * immunosuppressive disease (\< 6 months): cancers, lymphomas, positive serology for hiv, hepatitis, etc. * known renal failure or serum creatinine \> 120 µmole/l at admission * liver failure * uncontrolled hypertension * current pregnancy or women without contraception

Keywords: ischemia reperfusion myocardial infarction ciclosporin a acute myocardial infarction
paclitaxel in treating patients with recurrent or progressive advanced ovarian cancer

Conditions: Ovarian Cancer

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. purpose: phase ii trial to study the effectiveness of paclitaxel in treating patients with recurrent or progressive advanced epithelial ovarian cancer following previous paclitaxel.

objectives: i. evaluate the activity of paclitaxel when administered on a weekly schedule to patients with advanced ovarian cancer who have failed paclitaxel on a 3 or 24 hour infusion schedule. ii. evaluate the toxic effects of paclitaxel when administered on a weekly schedule in this patient population. iii. correlate response with quality of life outcomes, including symptom distress, performance status, and global quality of life. outline: this is a single center, open label study. paclitaxel is administered intravenously every week as a 1 hour infusion. patients receive prophylactic anti-allergy premedication prior to paclitaxel. projected accrual: 25-30 patients accrued per year.

Eligibility criteria:
disease characteristics: histologically confirmed recurrent or progressive epithelial ovarian cancer defined as: a serial rise in ca 125 over a minimum of 3 samples to a level greater than 50% of the upper limit of normal or measurable or evaluable disease disease progression following paclitaxel given by 3 or 24 hour infusion within the past 6 months patient characteristics: age: 18 and over performance status: karnofsky at least 60% life expectancy: not specified hematopoietic: agc at least 1500/ul platelet count at least 100,000/ul hepatic: bilirubin no greater than 1.5 mg/dl renal: creatinine no greater than 2.0 mg/dl other: no active or uncontrolled infections no history of grade 3-4 peripheral neuropathy of any etiology no previously developed severe hypersensitivity reactions to paclitaxel not pregnant or lactating patients of childbearing potential must use effective method of contraception prior concurrent therapy: biologic therapy: not specified chemotherapy: prior platinum based chemotherapy required complete recovery from the myelosuppressive effects of prior chemotherapy for a minimum of 3 weeks at least one prior regimen of paclitaxel by 3 or 24 hour infusion within 6 months prior to study, with no intervening chemotherapy endocrine therapy: no hormone therapy within 3 weeks of entry onto protocol radiotherapy: no prior radiation therapy to major bone marrow ares within 4 weeks of entry onto protocol surgery: not specified

Keywords: recurrent ovarian epithelial cancer
knowledge of young adults about genital herpes

Conditions: Genital Herpes

Summary: despite sex education in schools and prevention campaigns concerning sexually transmitted infections, genital herpes remains frequent infection. in 2016, according to the world health organization, more than 490 million people worldwide were living with a genital herpes infection.

the aim of the study is to describe knowledge of adults aged 25 to 35 about genital herpes (symptoms, transmission, prevention).

Eligibility criteria:
inclusion criteria: * men and women * aged 25 to 35 * having sex or not * agreeing to participate in the study exclusion criteria: - not agreeing to participate in this study

Keywords: knowledge young adults genital herpes
enhancing access to supportive services for women of color with metastatic breast cancer

Conditions: Metastatic Breast Cancer; Stage IV Breast Cancer AJCC V7

Summary: black and latina women experience disparities in supportive and palliative care access and outcomes. the goal of the proposed pilot study is to evaluate the feasibility and acceptability of a community navigator delivered supportive care intervention for historically underserved populations of women with metastatic breast cancer.

primary objectives: 1. establish the feasibility and acceptability of an adapted navigator delivered supportive care model called access to address supportive care needs for black and latina women with metastatic breast cancer. 2. determine the potential impact of access on cancer related distress, symptom burden, and utilization of supportive care services. outline: participants (n=60) are randomized to 1 of 2 groups: group 1/intervention group: participants complete 6 individualized behavioral/educational sessions focused on social determinants of health and supportive care with a trained community navigator followed by monthly phone call check ins for 4 months. participants complete questionnaires over the phone with a research coordinator at baseline, 6 and 9 months. group 2/attention control group: participants complete 6 phone calls with a research coordinator focused on supportive care resources followed by monthly phone call check ins for 4 months. participants complete questionnaires over the phone with a research coordinator at baseline, 6 months and 9 months. .

Eligibility criteria:
inclusion criteria: * women ≥18 years of age * english and/or spanish speaking * self-identify as latina and/or african american/black * ability to understand and the willingness to sign a written informed consent * stage iv breast cancer diagnosis, no time component exclusion criteria: * moderate to severe cognitive impairment * receiving inpatient hospice care * if patients were previously enrolled in aim 1 and aim 2 * currently working with a community navigator
optina eye to heart connection

Conditions: Coronary Artery Disease

Summary: this is a prospective cross-sectional, single-center retinal imaging study expecting to enroll approximately 400 male and female subjects ≥ 18 years of age. subjects having undergone clinically-indicated coronary angiography or coronary computed tomography angiography (ccta) within one month of consent at the montreal heart institute (mhi) will be screened for inclusion in the study.

this is a prospective cross-sectional, single-center retinal imaging study expecting to enroll aproximately 400 (280 cad and 120 control) male and female subjects ≥ 18 years of age. subjects having undergone clinically-indicated invasive coronary angiography or coronary computed tomography angiography (ccta) within one month of signed consent will be screened for inclusion in the study. subjects will be recruited at the montreal heart institute (mhi). during the screening visit, the investigator will review inclusion/exclusion criteria and the following information will be collected: demographic data including age and sex, relevant medical history including risk factors (hypertension, diabetes, dyslipidemia, smoking and obesity), history of cad, concomitant cardiovascular medications and laboratory tests (lipid profile, fasting glucose) subjects who provide written informed consent will undergo cognitive evaluation and an ophthalmic examination to identify any ocular exclusion criteria. all eligible subjects will then undergo hyperspectral retinal imaging using a metabolic hyperspectral retinal camera (mhrc) safety will be assessed through reporting of serious adverse events (saes) related to retinal imaging procedures.

Eligibility criteria:
inclusion criteria: * ability and willingness to give written informed consent * age 18 years or older at the time of informed consent * stable (non-emergent) typical or atypical symptoms suspicious for cad (e.g., chest pain, chest tightness, chest burning, shoulder pain, palpitations, jaw pain, or non-chest pain symptoms such as dyspnea or worsening effort tolerance. * patients having undergone clinically-indicated invasive coronary angiography or coronary computed tomography angiography within one month before consent signature exclusion criteria: 1. at screening visit 1: 1. asymptomatic subjects 2. previous coronary revascularization (e.g., coronary artery bypass graft surgery, stenting) 3. subjects being evaluated for other cardiac diseases (e.g., valvular disease, cardiomyopathy) 4. pregnant or breastfeeding women 2. at study visit 2 or ocular exclusion criteria: 1. medium or high opacity of the lens 2. bleeding in vitreous 3. pupillary dilation inadequate or contraindicated 4. deficient visual fixation 5. refractive error outside of the range -15 to +15 6. inability to obtain satisfactory images with the mhrc
the effect of weight loss on ovarian reserve

Conditions: Weight Loss

Summary: obesity affects on fertility. obese women have lower pregnancy rate after infertility treatments.they need more doses of hormone during ovarian stimulation, more days for stimulation. during ivf treatment less oocytes are collected and the quality of embryo also harmed. the first line treatment for those women with obesity and infertility is weight loss. the investigators' hypothesis is that weight reduction improves ovarian reserve and fertility treatment outcome.

the investigators have outpatient clinic for obesity and infertility. the patients undergoing program of 3 months with diet and physical activity. blood sample will take at the beginning of the program and at the end. the blood sample will evaluate for: amh, adiponectin, leptin, crp, colesterol, crp, smac in addition tvus will perform to evaluate afc.

Eligibility criteria:
inclusion criteria: * undergoing weight loss program exclusion criteria: * dropp out before comletion the weighy loss target

Keywords: mma, afc, ovarian reserve
thrombolysis in stemi patients compared with ppci on recanalization time in the context of the covid-19 outbreak.

Conditions: STEMI - ST Elevation Myocardial Infarction

Summary: during the outbreak of covid-19, for patients with acute st-segment elevation myocardial infarction with unclear infection, the time of primary pci is uncertain, and it is often expected to exceed 90 minutes or even 120 minutes. in indicated patients, intravenous thrombolysis has significantly improved the recanalization time of criminal vessels.

during the outbreak of covid-19, for patients with acute st-segment elevation myocardial infarction with unclear infection, the time of primary pci is uncertain, and it is often expected to exceed 90 minutes or even 120 minutes. in indicated patients, intravenous thrombolysis has significantly improved the recanalization time of criminal vessels. the purpose of this study was to compare the time from first medical contact to patency and safety (specifically symptom improvement, ecg st segment) between intravenous thrombolysis and concurrent patients with possible primary pci in a prospective, multicenter, non-randomized controlled manner. significant fall, angiographic examination showed criminal blood vessel timi blood flow grade 2-3)

Eligibility criteria:
inclusion criteria: * ecg confirms acute st-segment elevation myocardial infarction；the estimated time from fmc to recanalization is more than 120 minutes； exclusion criteria: * intracranial hemorrhage or stroke within the past 6 months; central nervous system injury, tumor or arteriovenous malformation; bleeding disease with known cause; suspected aortic dissection; non-compressible puncture surgery within 24 hours, etc.; 1 week of pregnancy or postpartum; uncontrolled hypertension; advanced liver disease; active peptic ulcer; prolonged or invasive cpr;
evaluation of food insecurity in adults and children with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: a survey of adults and parents of children with cystic fibrosis on food insecurity

a survey of adults and parents of children with cystic fibrosis to determine any correlation between food insecurity and bmi or food insecurity and fev1, and to determine what level of food insecurity is present.

Eligibility criteria:
inclusion criteria: have cf and are willing to complete a questionnaire during a routine clinic visit - exclusion criteria: * na
real-time behavioral interventions

Conditions: Cancer; Aging; Comorbidities and Coexisting Conditions

Summary: the goal of this study is to adapt an evidence-based sedentary behavior reduction intervention for men and women living in alabama and determine its feasibility, acceptance, and limited efficacy.

the goal of this study is to adapt an evidence-based sedentary behavior reduction intervention for men and women living in alabama and determine its feasibility, acceptance, and limited efficacy. community-based participatory research methods will be used to adapt an evidence-based curriculum. the adapted curriculum will be delivered via print-based materials and a mobile phone app developed by an external collaborator.

Eligibility criteria:
inclusion criteria: * • 50 to 75 years old at study enrollment; * currently living in alabama; * community-dwelling (i.e., not living in an assisted living facility or nursing home); * having access to the internet and a smart phone; * able to perform light-intensity physical activity (i.e., walking); * english speaking; * willing to consent to study procedure. exclusion criteria: * reporting more than 60 minutes of purposeful physical activity per week; * have an unstable mental condition that prevention study activities. determined by the physician health questionnaire.

Keywords: physical activity ecological momentary assessment health-related quality of life just-in-time adaptive intervention