Kornimate/medical-research-clean huggingface dataset:
the effect of inspiratory muscle training and respiratory physiotherapy on pulmonary functions, respiratory muscle strength and functional capacity in patients with robotic heart surgery

Conditions: Robotic Surgical Procedures; Heart Diseases

Summary: during the past decade, especially with the advancement of technology, major innovations and developments have been observed in the field of surgery. cardiac surgery is one of the important area of the surgery who renews itself day by day and adds innovations to the nature in terms of patients' comfort. one of the greatest developments in cardiac surgery in this sense is the tendency to reduce the size of the incisions with less interventional procedures. robotic surgery is getting more and more meaningful in this area. despite the downsizing of the surgical incisions, postoperative pulmonary complications have not completely disappeared in the robotic cardiac surgery. major respiratory problems following traditional cardiac surgery are gas exchange problems, atelectasis, decreased coughing force and sputum retention. the effectiveness of respiratory physiotherapy applied after traditional cardiac surgery for the resolution of these complications has been proved by various investigations. inspiratory muscle training (imt) has been found to improve autonomic modulation in heart failure patients as well as to increase inspiratory muscle strength in applied patient populations, reduce blood pressure in hypertensive patients, and increase functional capacity in elderly individuals. considering these benefits, when inspiratory muscle training is given to people with traditional cardiac surgery, respiratory muscle strengths, respiratory functions and functional capacities are increased compared to those not given to these patients. however, although there are complications after robotic cardiac surgery, there are no studies in the literature about respiratory physiotherapy or inspiratory muscle training. thus, the subject of this study is the comparison of the effects of standard respiratory physiotherapy and standard respiratory physiotherapy plus inspiratory muscle training on the respiratory functions, respiratory muscle strength and functional capacity of the patients with the robotic heart surgery.


Eligibility criteria:
inclusion criteria: * being suitable for robotic cardiac surgery, * being hospitalized to have a robotic heart surgery, * no complications during surgery, * to be extubated in intensive care unite after surgery , * stable clinical condition, * to be transferred from icu to the hospital room on the first day after surgery. exclusion criteria: * chronic obstructive pulmonary disease, * unstable angina, * acute decompensated heart failure, * acute pericarditis and myocarditis, * complex arrhythmia, * uncontrolled hypertension, * serious orthopedic and neurological impairment, * uncontrolled diabetes, * body mass index \> 30.

Keywords: robotic heart surgery inspiratory muscle training pulmonary function test 6-minute walk test respiratory muscle strength functional capacity
comparison of medication adherence between once and twice daily tacrolimus in stable renal transplant recipients

Conditions: Renal Disease; Renal Transplant

Summary: a critical aspect of real-world functioning following kidney transplantation involves how adherent individuals are to their medication regimens. regardless of the possible dangers of failing to adhere to anti-rejection medications, such as increased graft rejection, studies have reported rates of non-adherence at almost 50% following renal transplant. the cognitive aging laboratory under the direction of dr. wendy thornton, at simon fraser university, has previously identified relationships between several potentially important cognitive and psychosocial variables, and self-reported medication adherence in renal transplant recipients, including depressive symptoms, as well as everyday and traditional cognitive functioning \[4\]. the possibility that changes in dosing regimens for a given medication may have an additional impact on medication adherence presents an important issue worth further exploration. the current study will allow for more thorough delineation of the roles of psychosocial and cognitive predictors of adherence with state-of-the-art monitoring techniques. in addition, the investigators will assess whether different dosing formulations of tacrolimus impact adherence behaviors in renal transplant recipients. the proposed research has two primary aims to examine: 1. to examine the role of cognitive and psychosocial variables in predicting medication adherence in renal transplant recipients. 2. to examine whether different formulations of tacrolimus (once per day dosing versus twice per day dosing) will impact medication adherence in renal transplant recipients.


Eligibility criteria:
inclusion criteria: * a minimum of one year post renal transplant with a successful kidney graft and stable renal function (estimated glomerular filtration rate \[gfr (glomerular filtration rate)\] above 25 ml/minute per 1.73 m2). * currently prescribed tacrolimus * able to swallow pills * a minimum of grade six education * fluent in the english language. exclusion criteria: * refusal to or inability to give written informed consent. * any visual, hearing or other sensory/motor impairments which may interfere with the testing procedures. * have had a stroke determined to be of significant severity * have had a head injury determined to be of significant severity * have a current psychiatric diagnosis determined to be of significant severity * have the presence of an acute illness (e.g., metastatic cancer), neurological disease, and other major organ failure (e.g., end stage liver disease)

Keywords: kidney transplant tacrolimus medication adherence depression neuropsychological cognition self-efficacy everyday problem solving
early physiotherapy, mandibular motion and sensorial recovery after orthognathic surgery

Conditions: Mandibular Range of Motion; Pain; Sensorial Disturbance

Summary: several studies describe that the maximum mandibular opening decreases 60% -70% immediately after orthognathic surgery (os) and other variables, including laterotrusion, movement speed and facial mimic also decrease drastically. in addition, patients frequently experience temporary or permanent sensory orofacial disturbances ranging from 9% to 76% of cases. it has been described that scheduled early physiotherapy reduces these complications.

before the surgical intervention (t0) the maximum interincisal oral opening measurement, laterotrusion and maximum protrusion will be recorded by digital caliber. the overbite and the overjet, length of upper lip and lower facial third will be measured. the symmetry of the upper lip in a forced smile will be determined. the measurements made at t0 will be repeated at t1 (2 weeks after surgery), t2 (5 weeks after surgery), t3 (9 weeks after surgery), t4 (12 weeks after surgery), t5 (24 weeks after surgery) and t6 (after orthodontic removal).the level of pain during the measurements of the mandibular movements will be recorded in the visual analogue scale, and the self-reported area of the orofacial sensory alterations by means of a diagram and the objective area by means of the sensory discrimination test of two points will be determined. in t4, the impact of the status of the function and oral structures on daily activities will be recorded through a self-pass questionnaire based on the oral index daily performance questionnaire (oidp-sp). in the t6 the measurement of laterotrusion, protrusion and retrusion movements measured by gysi gothic arch will be performed.

Eligibility criteria:
inclusion criteria: * ≥18 years * patients treated with orthodontics and os for correction of dentofacial deformities. exclusion criteria: * patients diagnosed with temporomandibular disorders * patients diagnosed with orofacial pain * patients diagnosed with orofacial sensory alterations * patients not treated with orthodontics * patients and who need to undergo os interventions for the treatment of sleep apnea-hypopnea syndrome * patients that present cleft palate * patients that present cleft lip * patients diagnosed with syndromes that affect the orofacial structures.

Keywords: orthognathic surgery jaw rehabilitation jaw physiotherapy pain mandibular range of motion sensorial disturbance
sensory integration versus fine motor intervention in children with autism

Conditions: Autism Spectrum Disorder

Summary: clinically, infants with autism spectrum often display gross motor delays in supine, prone, and sitting skills in their first year of life.


Eligibility criteria:
inclusion criteria: * age ranges from 8 to 12 years. * mild to moderate autistic features exclusion criteria: • significant visual or auditory defects.

Keywords: autism spectrum disorder quality of life sensory integration fine motor skills
does cold saline used to inflate a balloon tamponade catheter more significantly reduce blood loss from postpartum hemorrhage than room temperature saline?

Conditions: Postpartum Hemorrhage

Summary: to determine if a balloon tamponade catheter filled with cold saline is more effective than a catheter filled with room temperature saline in controlling post partum hemorrhage.

when post partum hemorrhage occurs one mode of therapy is to place a balloon tamponade catheter into the uterus to compress the bleeding vessels. when this mode of therapy has been chosen by the attending physician the patient will be randomized to either the room temperature arm (control) or the cold arm (study). the balloon catheter is placed through the vagina into the uterus and inflated using normal saline; room temperature for the control group and approximately 32 degrees f for the study group. traction is placed on the catheter to tamponade the vessels in the lower uterine segment. blood from the uterus passes through a central lumen of the balloon and will be collected and measured. total measured blood loss for each group will be compared.

Eligibility criteria:
inclusion criteria: * women 18-45 years old who have just delivered they baby vaginally who now have uncontrolled bleeding from their uteri exclusion criteria: * anyone outside of the specified age group * anyone who declines to participate in the study
study on abnormal dopamine synthesis and connectivity according to the antipsychotic treatment response in schizophrenia

Conditions: Schizophrenia

Summary: the purpose of this study is to evaluate abnormal dopamine synthesis and connectivity according to the antipsychotic treatment response in schizophrenia.


Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia * clinically stable state exclusion criteria: * history of previous head injury, epileptic disorder, other medical comorbidity * substance abuse/dependence
a single-center randomized controlled study on the effect of pharmacogenomics trial on clinical efficacy in patients with depression

Conditions: Depressive Disorder; Pharmacogenomic Drug Interaction

Summary: the purpose of this clinical trial is to explore the efficacy of drug therapy under the guidance of pharmacogenomics test in the treatment of patients with depression. the main questions to be answered in this study are: 1. whether the drug treatment regimen under the guidance of pharmacogenomics test is beneficial to the rehabilitation of patients with depression. 2. pharmacogenomics tests whether it can reduce adverse drug reactions during treatment, and be evaluated by the scale before and after treatment. the researchers will compare the pharmacogenomics test group with the healthy control group to see the effect of drug therapy under the guidance of pharmacogenomics test on the efficacy of patients with depression.

drug treatment of mental disorders is often seriously hindered by huge differences in individual drug responses or drug side effects, which are closely related to genetic factors. pharmacogenomics testing can help clinicians to provide better drug choices for patients. in this study, a single center randomized controlled design was used, including 300 cases in the drug gene detection group and 300 cases in the healthy control group. hamilton depression scale (hamd) and side effects scale (tess) were used to evaluate the efficacy of pharmacogenomics test in the treatment of depression before and after treatment.

Eligibility criteria:
inclusion criteria: 1) diagnosis of depressive disorder based on dsm-v criteria by two or more senior psychiatrists; 2) hamilton depression scale (hamd) score more than 14; 3) age between 14 and 75 years; 4) completed at least middle school education or higher and capable of completing the assessment scales; 5) good compliance with medication treatment. exclusion criteria: 1) presence of mental retardation or significant medical history of other major physical illnesses (including a history of cranial trauma or infection, intracranial tumors, cerebrovascular diseases, epilepsy, etc.); 2) history of benzodiazepine sedative-hypnotic drug, alcohol, or other substance abuse; 3) history of electroconvulsive therapy; 4) pregnancy or lactation.

Keywords: depressive disorder pharmacogenomic drug interaction
a trial to compare pringle maneuver with either infrahepatic inferior vena cava clamping or low central venous pressure

Conditions: Liver Resection

Summary: the purpose of this study is to better comprehend the benefits and efficacy of portal triad clamping with infrahepatic ivc clamping during complex hepatectomy. a randomized comparative trial was performed to compare ptc(pringle triad clamping) with either infrahepatic ivc clamping or low central venous pressure in complex liver resections.

to better comprehend the benefits and efficacy of portal triad clamping with infrahepatic ivc clamping during complex hepatectomy. a randomized comparative trial was performed to compare ptc with either infrahepatic ivc clamping or low central venous pressure in complex liver resections. 192 consecutive patients were involved in this study and allocated equally to two groups. preoperative demographic and clinical data, details of surgical procedure, pathologic diagnosis, postoperative course and complications were collected prospectively.

Eligibility criteria:
inclusion criteria: 1. patients who were assessed by preoperative medical imagings to have a high risk of backflow bleeding from the major hepatic veins and the ivc, based on the size and location of the tumor. the tumors were ≥5 cm in diameter and they involved the liver segments 7, 8 and/or the cranial portion of segment 4. these tumors were in close proximity or were compressing, but had not actually invaded, the major hepatic veins or ivc 2. pugh-child grade a 3. indocyanine green retention rate at 15 minutes (icgr15) \< 10%; 4. acceptable clotting profile (platelet count ≥ 50 ×109/l and prothrombin activity ≥ 60%) 5. no previous liver resection. exclusion criteria: 1. extrahepatic metastases in patients with malignancy; 2. patients who refused to take part in this study.

Keywords: blood loss hepatectomy prospective study ptc
tobramycin inhalation powder (tip) in cystic fibrosis patients infected with burkholderia cepacia complex

Conditions: Cystic Fibrosis; Burkholderia Cepacia Infection

Summary: the objective of this study is to determine if tobramycin inhalation powder (tip) can reduce the amount of burkholderia cepacia complex (bcc) species - type of bacteria, in the sputum of cystic fibrosis patient.


Eligibility criteria:
inclusion criteria: * age 6 years or older * diagnosis of cf based on the following: sweat chloride\>60 meq/l or genotype with 2 identifiable mutations consistent with cf; and one or more clinical features consistent with cf. * chronically infected with a burkholderia cepacia complex species (\>50% of respiratory specimens positive in the 24 months prior to screening). * able to produce sputum (expectorated or induced). * able to reproducibly perform pulmonary function testing. * written informed consent provided. exclusion criteria: * post lung transplantation. * pregnancy. * acute exacerbation requiring iv or oral antibiotics within 14 days * patients currently receiving inhaled tobramycin/tobi * a septic or clinically unstable patient, as determined by the investigator.

Keywords: inhaled antibiotics
study of prognostic factors in patients admitted to icu for stroke

Conditions: Stroke; Critically Ill

Summary: outcome of stroke patients admitted to the intensive care unit the intensive care unit (icu) is poor and haemorrhagic stroke, fixed dilated pupil(s) and gcs \<10 are associated with increased mortality and poor functional outcome. however little is known about the impact of clinical events occuring during the icu stay (ventilator acquired pneumoniae, shock, dysglycemia....). the objective of this study was to determine the mortality rate and the functional outcomes of stroke patients admitted to icu and to identify predictors of poor outcome in this population.


Eligibility criteria:
inclusion criteria: * acute stroke * icu admission for acute stroke * 1 organ dysfunction : coma, shock, respiratory failure exclusion criteria: * refuse participation
computer assisted cognitive behavior therapy for obsessive compulsive disorder: a comprehensive stepped-care approach

Conditions: Obsessive Compulsive Disorder

Summary: the goal of this project is to improve access to effective treatments for obsessive compulsive disorder (ocd) through the use of web-based cognitive behavioral therapy (cbt) treatment. there intervention involves both a computer program (bt steps) and human interaction via telephone. the investigators will test the efficacy and feasibility of computer therapy alone (n=35), computer plus a non-therapist coach (n=35), and computer plus a cbt therapist coach (n=35

the need for evidence-based mental health treatments i.e., 'treatment based on the best available science or research evidence"1, has been stressed from scientific, ethical, and marketing perspectives. while empirical evidence supports both the efficacy and effectiveness of cognitive behavior therapy (cbt) for obsessive-compulsive disorder (ocd), demand for clinicians trained in these approaches far exceeds supply. new technologies provide the opportunity to facilitate access to this specialized treatment. a growing body of research has found that web-based self-administered psychotherapy is highly effective, cost-efficient, and can achieve clinical improvements similar to those obtained with clinician administered therapy. the long-term goal of this project is to improve clinical and occupational functioning and decrease disability associated with ocd by improving access to effective treatments through the use of web-based cbt treatment. the intervention involves a computer program (bt steps) and human interaction via telephone. the inclusion of human interaction for coaching and encouragement has been found to significantly increase compliance and success rates in computerized self-help. whether treatment outcomes differ when this coaching is done by a therapist versus when done by a trained non-therapist has not been studied. this is the first program to examine a hybrid model involving different levels of remote clinician coaching in combination with an on-line self-help tutorial. in phase i the investigators will test the efficacy and feasibility of computer therapy alone (n=35), computer plus nontherapist coach (n=35) and computer plus cbt therapist coach. in phase ii the investigators will do a fully powered study comparing our model to traditional face-to-face therapy.

Eligibility criteria:
inclusion criteria: * age 18 or above * have clinically significant ocd * ybocs score of 16-32 exclusion criteria: * significant comorbid depression * serious suicide risk * psychosis or psychotic disorder

Keywords: obsessive compulsive disorder computer assisted therapy cognitive behavior therapy cognitive therapy
applicability of 3d printing and 3d digital image reconstruction in the planning of complex liver surgery (liv3dprint).

Conditions: Liver Diseases; Surgery

Summary: three-dimensional (3d) printing has gained popularity in medicine over the last decade. once 3d printers have become more affordable, the true strength of this technique has been recognized because of its ability to obtain anatomical models based on the unique characteristics of each patient. liver resections are challenging operations because of the complex nature of the liver and venous anatomy within the liver, so 3d imaging is a promising new tool for surgical planning.


Eligibility criteria:
inclusion criteria: * complex liver tumors (bilobar disease, infiltration of suprahepatic veins or requiring two-time resection or intrahepatic vascular reconstruction). * preoperatively was performed, a ct scan and / or mri of all patients were performed to document the tumor distribution, estimate remaining liver volume, and identify tumor-vessel relationships in order to know the intraoperative vascular anatomy. exclusion criteria: -

Keywords: complex liver surgery 3d printing
preterm infants: light effects on health and development

Conditions: Preterm Infant Health; Preterm Infant Development

Summary: preterm babies cared for in the intensive care nursery are exposed to amounts of light that are very different from the exposures to an unborn baby or the newborn term baby. currently many nurseries try to protect premature babies from too much light. they may also try to create light conditions of day and night like many parent homes. some studies have shown improvements in health and development of babies cared for in nurseries that try to change light for premature babies.


Eligibility criteria:
inclusion criteria: * infants were \< 7 days of age and were born at 28 weeks or \< 28 weeks exclusion criteria: * known anomalies associated with neurological or visual problems (e.g., congenital glaucoma, down syndrome)

Keywords: cycled light preterm infants infant neurodevelopment infant sleep
osmoprotective containing lubricants in dysfunctional tear syndrome and post refractive surgery patients

Conditions: Dry Eye; Ametropia

Summary: the purpose of this project is to determine the effectiveness of an eyewash osmoprotective lubricant comparing to castor oil containing and non-osmoprotective lubricants in different types of dts and post refractive surgery patients.


Eligibility criteria:
inclusion criteria: 1. adult patients willing and able to comply with the protocol who are not planning changes in diet, topical or systemic drugs during the course of study. 2. dts all the patients will be diagnosed for mild to moderate evaporative dry eye as defined by following criteria that will be given by outcome measurements: 2.1. break up time. 2.2. lissamine green staining. 2.3. osdi and patient symptomatology questionnaire. 3. the patients, whose are going to be submitted for refractive surgery. exclusion criteria: 1. any patient with punctual occlusion or punctual plugs. 2. patients with active ocular infection or inflammatory disease, history of herpetic keratitis, history of retinal detachment, concurrent contact lens use during trial period, 3. patients with glaucoma, anterior membrane dystrophy, active trichiasis or any eyelid globe malposition abnormality. 4. patients with epiphora. 5. patients must not have participated in any investigational therapeutic drug or device trial within the 30 days prior to their start date for this trial. 6. any patient suffering from organic brain syndromes or major psychiatric disorder that would interfere with compliance or subjective reporting will be discouraged from participating in this trial.