Kornimate/medical-research-clean huggingface dataset:
feasibility of doppler ultrasound for pulse detection in out-of-hospital cardiac arrest patients

Conditions: Cardiac Arrest, Out-Of-Hospital

Summary: the goal of this prospective observational study is to investigate the feasibility of using doppler point-of-care ultrasound on the femoral artery with a portable device to assess the presence of a pulse in patients suffering from cardiac arrest in the out-of-hospital environment. the main question is how often researchers are successful in acquiring the necessary ultrasound signal in the out-of-hospital environment.

in this prospective observational study, a dedicated research team will be dispatched to cardiac arrest patients treated in the prehospital environment by emergency medical services (ems). the team will use a portable ultrasound device to identify the femoral artery and conduct a pulsed wave (pw) doppler measurement during chest compressions as well as during chest compression pauses for rhythm analysis and save the recorded images. these ultrasound pulse checks will be conducted in parallel with the normal treatment of the patient, including manual pulse checks, and will only be conducted if ultrasound is possible without interference in the resuscitation. all treatment decisions will rest with the treating ems team.

Eligibility criteria:
inclusion criteria: * out-of-hospital cardiac arrest treated by ems * minimum age of 18 years exclusion criteria: * pregnancy or suspected pregnancy * disapproval of the treating ems team * adults under legal guardianship * inability to perform femoral artery doppler ultrasound due to limited access to the patient and possible interference with the treating ems team * inability to perform femoral artery doppler ultrasound due to injuries or anatomic abnormalities in the femoral region or necessary emergent medical interventions in the femoral region * decision to transfer the patient to the hospital with ongoing cpr for emergent procedures such as extracorporeal cpr before femoral artery doppler ultrasound could be attempted * inability to safely perform femoral artery doppler ultrasound due to environmental hazards

Keywords: cardiac arrest out-of-hospital cardiac arrest ohca ultrasound point-of-care ultrasound pocus pulse check pocus pulse check doppler ultrasound femoral artery
impact of art adherence on hiv persistence and inflammation

Conditions: Human Immunodeficiency Virus

Summary: the purpose of this study is to evaluate the relationship between anti-retroviral therapy (art) adherence with levels of human immunodeficiency virus (hiv) reservoir and residual viremia in suppressed, hiv-infected individuals on chronic art.

understanding whether the size and dynamics of the hiv reservoir are associated with adherence, measured by an objective biomarker, could have significant clinical and therapeutic implications for art and hiv cure. 1. first, this aim will quantify levels of ca-rna, ca-dna, and plasma residual viremia in suppressed, hiv infected individuals and correlate them with levels of tfv-dp in dbs as a measure of cumulate drug exposure (adherence). 2. second, this study will evaluate the changes in the hiv reservoir in relation to changes in art adherence over time.

Eligibility criteria:
inclusion criteria: 1. hiv-infected males and females, 2. ages 18 years and older, 3. taking any tfv-based regimen, 4. hiv suppression \<20 copies/ml for at least 12 months; 5. not co-infected with hcv; 6. able and willing to give informed consent. exclusion criteria: 1. pregnancy. 2. refusal to participate.

Keywords: anti-retroviral therapy
treatment with [90]y-ibritumomab tiuxetan versus no treatment in patients with follicular non hodgkin lymphoma (stage iii or iv) having achieved a partial or complete remission after first line chemotherapy

Conditions: Lymphoma, Non-Hodgkin

Summary: the aim of the study is to test \[90\]y-ibritumomab tiuxetan, a radioactive antibody, in patients with stage iii or iv follicular lymphoma whose disease is in partial or complete remission after first line chemotherapy. the radioactive antibody will be compared with no further treatment to see which is better in the long term after standard lymphoma treatment.

the study has previously been posted by schering ag, germany. schering ag, germany has been renamed to bayer schering pharma ag, germany. bayer schering pharma ag, germany is the sponsor of the trial.

Eligibility criteria:
inclusion criteria: * non hodgkin lymphoma stage iii or iv at timepoint of diagnosis * patients who have achieved a remission after first line chemotherapy * no less than 6 weeks and no more than 12 weeks since last dose of chemotherapy * older than 18 years * written informed consent exclusion criteria: * any other anticancer treatment for nhl except the preceding first line chemotherapy * prior radiation therapy * patients who have not recovered from the toxic effects of the first line chemotherapy * any other cancer or history of cancer less than 10 years ago * patients with known hiv positivity * patients with pleural effusion or ascites * female patients who are pregnant or breast feeding (women of childbearing potential must have a negative serum pregnancy test at study entry) * adults not employing an effective method of birth control during study treatment and 12 months thereafter * patients unable or unwilling to comply with protocol

Keywords: follicular non hodgkin lymphoma
physical exercise on simple inflammatory markers, systemic immune inflammation index, and systemic immune response index

Conditions: Schizophrenia; Physical Exercise

Summary: mental health is defined as a state of well-being in which a person can realize their talents, cope with the normal stresses of life, and support society by working efficiently and productively. in other words, mental health is a dynamic internal balance that enables individuals to use their diversity of skills in harmony with the universal values of society.

the aim of this study was to investigate the effect of physical exercise on simple inflammation markers, systemic immune inflammation index and systemic inflammation response index in patients with schizophrenia. no other study examining the effect of exercise on these parameters was found in the literature. therefore, considering the importance of our study, our findings may contribute to the literature and improvement for mental health systems, especially for people with psychotic disorders such as schizophrenia.

Eligibility criteria:
inclusion criteria: * individuals diagnosed with schizophrenia by a physician according to dsm-v criteria patients treated at cmhc individuals with schizophrenia who are 18 years of age or older exclusion criteria: * those who do not consent to participate in the study patients with a diagnosis other than schizophrenia pregnancy patients with chronic metabolic diseases such as diabetes, heart problems and cancer
prognostic factors affecting recurrence and disease-free survival after surgical resection for cancer rectum

Conditions: Rectal Cancer

Summary: tumor recurrence after curative surgical resection for rectal cancer is a serious complication that greatly affects the overall morbidity and the outcome. this study aims to identify the different prognostic factors affecting recurrence and disease-free survival after surgery.

a retrospective analysis of patients operated for cancer rectum with curative intent from. exclusion criteria will include patients with familial adenomatous polyposis, multiple synchronous or metachronous rectal cancers, and death within 3 months. incomplete patients' files and patients that lost follow-up will be excluded. demographic, histopathological, follow up and outcome data will be collected from completed patients' files. demographics include age, gender, family history, and chief complaint at the presentation. histopathological data include tumor grade, vascular-perineural invasion, the total number of lymph nodes removed, and positive lymph nodes. lymph node ratio will be defined as the ratio of positive lymph nodes to the total number of retrieved lymph nodes in a histopathology specimen. disease-free survival will be calculated for each patient based on the time of surgery to the time of recurrence detection.

Eligibility criteria:
inclusion criteria: * patients who had curative surgery for cancer rectum. exclusion criteria: * patients with familial adenomatous polyposis (fap), multiple synchronous or metachronous rectal cancers, and death within 3 months * patients that lost follow-up will be excluded.

Keywords: cancer rectum recurrence disease free survival
the optimal surveillance frequency for patients with gastric neuroendocrine carcinoma

Conditions: Gastric Neuroendocrine Carcinoma

Summary: due to lacking of evidence on surveillance for gastric neuroendocrine carcinoma (g-nec), this study aimed to determine the optimal postsurgical surveillance strategy for g-nec patients and compare its cost-effectiveness with traditional surveillance strategies.

the development of existing follow-up strategies is mainly based on experts' consensus and researches on recurrence patterns due to the lack of direct evidence and unified standards. on the one hand, it is unreasonable to carry out the same postoperative surveillance for all g-nec patients. in addition to the early detection of recurrence, the optimal follow-up strategy should also balance cost and effectiveness. there were no criteria for the arrangement of follow-up in different guidelines, and the optimal postoperative follow-up strategy for patients with g-nec remains unclear. patients with g-nec from 21 centers in china were included. cost-effectiveness were assessed by markov model.

Eligibility criteria:
inclusion criteria:this multicentre retrospective study included patients with gastric neuroendocrine neoplasms who underwent surgery in 21 centres of the study group for gastric neuroendocrine tumours in china from january 2008 to december 2016. radical surgery included a d2 lymphadenectomy consistent with the japanese gastric cancer treatment guidelines. exclusion criteria: patients with tumours of unknown pathology (only neuroendocrine neoplasms recorded without detailed information); patients with gastric nets; patients who had endoscopic submucosal dissection or endoscopic mucosal resection; patients who received neoadjuvant chemotherapy; patients who died within 3 months of surgery from postoperative complications; and patients with unknown tumour size or who were lost to follow-up
functional recovery in critically ill children

Conditions: Critical Illness; Children

Summary: intensive care unit-acquired weakness (icu-aw) is a well-recognized, important and preventable sequelae of critical illness, affecting up to 60% of adult icu patient. icu-aw is associated with increased mortality and length of stay, and negatively impacts long-term functional outcomes and quality of life in affected patients and their caregivers. while delayed mobilization adversely affects clinical outcomes, early rehabilitation in the critically ill adult population is safe, feasible, cost effective, results in more ventilator free-days and better functional outcomes at hospital discharge. in contrast, there is a paucity of this research in pediatrics. our research suggests that immobilization is common in critically ill children, and rehabilitation is delayed particularly in the sickest children who are arguably at highest risk of morbidity. it is unclear however, whether delayed rehabilitation leads to adverse outcomes in critically ill children, as has been demonstrated in adults. our objectives of this study are to evaluate if immobilization and delayed rehabilitation negatively impacts short-term clinical outcomes and the time to functional recovery in critically ill children. the investigators hypothesize that the following factors may influence functional recovery and morbidity in critically ill children: * pre-morbid condition * age * time-to-initiation of acute rehabilitation * critical illness disease severity

overall study objectives: 1. to describe the functional recovery following prolonged immobility and delayed rehabilitation in critically ill children. 2. to explore the predictors of impaired functional recovery following immobilization in critically ill children. prior to conducting a definitive multi-centre study to answer our research questions and achieve our study objectives above, we will conduct a pilot study in order to demonstrate feasibility.

Eligibility criteria:
inclusion criteria: * age over 12 months to 17 years * pccu stay of ≥ 48 hours * patient is limited to bed-rest and has not been mobilized during the first 48 hours of pccu admission * equal to or greater than one organ dysfunction on pccu admission (as measured by pelod) * informed consent of patient/substitute decision maker. exclusion criteria: * age: \< 12 months or ≥18 years * patients admitted to step-down/intermediate care * patients transferred from neonatal intensive care unit and never discharge home. iv) patients who are already mobilizing well, or are at baseline functional status at time of screening v) admission diagnosis of a neuromuscular disorder: e.g. acute guillain-barré syndrome, botulism, myasthenia gravis), or acute spinal cord injury/transverse myelitis vi) not expected to survive pccu/hospital stay vii) previously enrolled into study less than 6 months ago and/or still undergoing study procedures at time of screening

Keywords: functional recovery, critical illness, pediatrics
modified-flai induction and consolidation chemotherapy in elderly patient with acute myeloid leukemia (aml)

Conditions: Acute Myeloid Leukemia

Summary: a phase ii clinical trial evaluating the efficacy and tolerability of induction and consolidation chemotherapy comprising fludarabine, cytarabine and attenuated-dose idarubicin (modified-flai) in the elderly patients with acute myeloid leukemia.


Eligibility criteria:
inclusion criteria: * previously untreated aml (excluding acute promyelocytic leukemia) * age greater than 60 years old * ecog ps (eastern cooperative oncology group performance scale) less than 2 * adequate hepatic/ renal/ cardiac function exclusion criteria: * acute promyelocytic leukemia * significant cardiac disease * combined non-hematologic malignancy * aleukemic leukemia (only granulocytic sarcoma) * cns (central nervous system) involvement * significant comorbidity/ uncontrollable bleeding tendency

Keywords: fludarabine aml efficacy tolerability
a study to assess the efficacy and safety of hrg2005 inhalation in patients with moderate to severe chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: this is a randomized, double blind, double dummy, active-controlled, parallel-group study to assess the efficacy and safety of hrg2005 inhalation in patients with moderate to severe chronic obstructive pulmonary disease. approximately 200 patients with moderate to severe copd will be randomized into the study.


Eligibility criteria:
inclusion criteria: 1. able and willing to provide written informed consent and to comply with the study protocol; 2. subjects 40 years of age or older (inclusive), male or female subjects; 3. subjects with an established clinical history of copd; 4. a post-bronchodilator fev1/fvc ratio must be \<0.7 at screening and fev1 must be \<80% and ≥30% predicted normal at pre-randomization; 5. a documented history of ≥ 2 moderate or ≥ 1 severe copd exacerbation in the previous 12 months; 6. tobacco use: current or former smokers with a history of at least 10 pack-years of cigarette smoking; 7. a score of ≥10 on the copd assessment test (cat) at pre-randomization. exclusion criteria: 1. subjects who required systemic corticosteroids or antibiotics or hospitalized due to poorly controlled copd or who had lower respiratory tract infections that required antibiotics within 4 weeks prior to screening to pre-randomization; 2. subjects who had respiratory tract infections that required antibiotics within 2 weeks prior to screening to pre-randomization; 3. subjects with other respiratory or respiratory related diseases, including but not limited to asthma, active tuberculosis, lung cancer, interstitial pulmonary disease, α1-antitrypsin deficiency, pulmonary heart disease, clinically significant pulmonary hypertension, clinically significant bronchiectasis, or other active pulmonary disease; 4. subjects with lung volume reduction surgery within the 12 months prior to screening; 5. subjects who have other known serious medical conditions； 6. subjects receiving oxygen therapy required for greater than 15 hours a day; 7. clinically significant electrocardiogram abnormality； 8. subjects with significant laboratory abnormality at screening； 9. suspected allergy to any ingredient in the study drug; 10. participation in clinical trials of any drug or medical device (except for screening failures) within 4 weeks before screening, or within 5 half-lives of the drug at screening (whichever is longer); 11. pregnant or lactating females; 12. history of drug abuse within one year before screening 13. other conditions judged by the investigator to be not suitable to participate in the trial.
effect of quercetin in prevention and treatment of oral mucositis

Conditions: Chemotherapy Induced Oral Mucositis

Summary: the study aims to evaluate the effect of quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.


Eligibility criteria:
inclusion criteria: * patient under chemotherapy * for a hematologic malignancy * the hematologist permits the trial on the patient * agreement of patient for participating in the trial exclusion criteria: * presence pf any oral lesion at the beginning of the trial * loss of follow up * use of digoxin and cyclosporine * patient death

Keywords: quercetin chemotherapy mucositis hematologic malignancies
prolonged symptoms and reasons for consultation in town medicine associated with covid-19 infection in the hauts de france region

Conditions: Covid19

Summary: several publications document the occurrence of prolonged or late-onset symptoms beyond 3 weeks after the first clinical manifestations of sars-cov2 infection. these manifestations may be related to thromboembolic or inflammatory events or other mechanisms that are not yet well understood. the psychosomatic origin secondary to psychiatric disorders prior to the infection or in reaction to it is also to be evoked. the identification of the clinical manifestations observed, and their clinical and paraclinical evolution are essential to better understand the natural evolution of covid-19, to specify the physiopathological mechanisms and to identify potential avenues of management for the patients. in addition, the impact of covid-19 infection on primary care visits is not known. in general practice, these patients benefit from explorations and even diagnoses that may explain the persistence of symptoms (autoimmune diseases, thrombosis, somatoform disorders, hyperventilation syndrome, etc.). the objective of the coco_vi_late project is to carry out a cross-sectional study of patients presenting persistent and/or recurrent symptoms after an infection with sars-cov-2 who will be compared to individuals with a short form of infection with covid-19


Eligibility criteria:
inclusion criteria: a- for covid cases: 1. consultation in a city doctor's office 2. positive sars-cov-2 rt-pcr result or positive sars-cov-2 serology 3. patient symptomatic or not definition of symptomatic : 1. anosmia 2. or ct scan suggestive of covid 19 3. or ≥ 2 symptoms contemporaneous with virologic sampling among: asthenia, cough, dyspnea, fever, myalgias, dysgeusia, diarrhea and not present previously at diagnosis b-. for non covid cases: 1. consultation in a city doctor's office 2. no known covid+ serology 3. no known rt- pcr sars-cov-2 4. no clinical suspicion of covid-19 infection exclusion criteria: 1. minor patient 2. refusal to participate 3. patient under protection 4. patient requiring hospitalization for covid-19 (excluding non-emergency hospitalization) 5. patient consulted for the following reason only: treatment monitoring, treatment renewal or certificate, hospital discharge
secondary lymphedema due to human adjuvant disease

Conditions: Lymphedema, Secondary; Lymphedema of Leg; Granuloma, Foreign-Body

Summary: this observational, descriptive, retrospective study the clinical and imaging findings of 10 lower legs of 5 patients with previous history of injection of modeling substances for cosmetic purposes at buttocks and hips ande developed lower limb edema. lower limb lymphedema index and lymphoscintigraphy findings were evaluated and reported.

lymphoscintigraphy findings were reported with the transport index (ti), were any value over 5 will represent abnormalities in lymphatic function.

Eligibility criteria:
inclusion criteria: * both sex * over 18 years old * history of injection of modelling substances for cosmetic purposes * history of lower limb edema exclusion criteria: * history of primary lower limb lymphedema * reject to participate * confirmed other causes of edema

Keywords: human adjuvant disease
cm asia nail with as2 without as2 （as2 study）

Conditions: Trochanteric Fracture of Femur

Summary: the purpose of this study is to compare reduction positon maintenance rate at 3 weeks post-operatively between patients operated with anterior support screw (as2) and without as2 technique in rct setting. total 240 cases(each arm 120 cases) will be enrolled at maximum 15sites, total study duration is 22months.

objective： to compare fracture reduction maintenance rate at 2-3weeks post-operatively between patients operated with as2 (investigational group) and patients operated without as2 (control group) using same implant system (znn cm asia, zimmer biomet). endpoint： primary： the rate of reduction position maintenance at 2-3 weeks post-operatively. secondary： surgery time / fracture type / postoperative reduction position / ct assessment / safety information

Eligibility criteria:
inclusion criteria: in order to be eligible to participate in this study, a subject must meet all of the following criteria. * eligible for intramedullary nailing. * fracture type is classified as 3-partb or 4-part fracture in 3d-ct (three dimensional computed tomography) classification (nakano), and combination with a subtype p in lateral classification (ikuta) at preoperative ct (computed tomography) assessment.(in the case of classified in radiograph (x-ray) at preoperative: classified as type 4 or type 5 in jensen classification, and combination of subtype p in lateral classification (ikuta)) * japanese male or female * \> 20 years of age * primary closed intertrochanteric fracture of the femur * subjects willing to return for follow-up evaluations. exclusion criteria: a potential subject who meets any of the following criteria will be excluded from participation in this study. * patient who cannot take ct image within 3 days and 2-3weeks after surgery. * uncooperative patient or patient with neurologic disorders who are incapable of following directions.
the reach study: a novel values-based intervention to increase endocrine therapy adherence among breast cancer survivors

Conditions: Breast Cancer

Summary: this pilot trial compares two online interventions to improve adherence to anti-hormonal medication among women with the most common form of breast cancer (estrogen receptor-positive).


Eligibility criteria:
inclusion criteria include: 1. women in colorado treated for stage 0 to iii estrogen receptor-positive breast cancer who have completed primary cancer treatment (surgery, chemotherapy, and/or radiation) and within the past 2.5 years, have been prescribed anti-hormonal therapy 2. take their anti-hormonal therapy medication at least occasionally and have at least 1 more year left on their prescription 3. report at least 1 factor that makes taking their anti-hormonal therapy medication difficult 4. have internet access