Kornimate/medical-research-clean huggingface dataset:
screening and treatment of sahs in patients with acute ischemic stroke

Conditions: Ischemic Stroke; Sleep Apnea Syndrome

Summary: ischemic stroke is a kind of common disease with great harm. in acute stage of stroke there is sharply increasing morbidity of sleep apnea hypopnea syndrome. our suppose that treatment with noninvasive ventilation for patients with acute ischemic stroke should improve the functional prognosis（measuring with 90d modified rankin score）.

in acute state of ischemic stroke，if patients with sleep apnea hypopnea syndrome may need additional respiratory management such bi-level positive airway pressure.we supposed the patients with stroke can take benefit of functional recovery form bi-level positive airway pressure. we choose the patients who suffered ischemic stroke in 48 hours ，then evaluate the respiratory status. stroke patients who were diagnosed as sleep apnea hypopnea syndrome will accept additional treatment with bi-level positive airway pressure for 7 night（per night 6 hours）.then the modified rankin scale score and nihss will be recorded at 30 days and 90 days after stroke.

Eligibility criteria:
inclusion criteria: * ischeic stroke onset within 48 hours , nihss:4-15 exclusion criteria: * mrs\>2 before onset of enrollment severe hepatic renal insufficiency cancer in reached an advanced stage

Keywords: stroke, sahs, bipap
1-day cbt workshops for ppd

Conditions: Postpartum Depression

Summary: postpartum depression (ppd) affects up to 20% of women and has profound effects on women and their families. clinical practice guidelines recommend that the majority of women with ppd receive psychotherapy. a previously validated 1-day cbt workshop has been adapted for depression for use with women experiencing ppd and living in the community. 476 women will be randomized to active treatment or a 12 week wait list in each setting and compare changes in depression, mother-infant attachment, service utilization, quality of life, and offspring behaviour.

postpartum depression (ppd) affects up to 20% of women and has profound effects on women and their families (1,2). indeed, the cost of one case of ppd is estimated to exceed $150,000 (3). unfortunately, fewer than 15% of women with ppd receive evidence-based care (4), which is at least partly due to difficulties accessing treatment, particularly therapies that are most preferred (e.g., psychotherapy (5)). clinical practice guidelines recommend that the majority of women with ppd receive psychotherapy (e.g., cognitive behavioural therapy (cbt)) as a 1st-line treatment (6). moreover, consensus recommendations such as those made by the us preventive services task force suggest that screening only occur in settings where evidence-based counselling such as cbt is readily available (7). in order to increase access to treatment, screening efforts have been undertaken by public health units province-wide in ontario. this has occurred despite the widespread availability of evidence-based psychotherapies. a previously validated 1-day cbt workshop has been adapted for depression for use with women experiencing ppd and living in the community. 476 women will be randomized to active treatment or a 12 week wait list in each of 5 settings (simcoe county, kitchener-waterloo region, halton region, prince edward county, elgin county), and compare changes in depression, mother-infant attachment, service utilization, quality of life, and offspring behaviour. if this intervention is eventually proven effective, more women would receive treatment and the burden of ppd on women, families, and the healthcare system would be significantly reduced. providing women with ppd with cbt skills at this crucial stage in life also has the capacity to prevent future depressive relapse with significant benefits for patients, families, employers, and the healthcare system.

Eligibility criteria:
inclusion criteria: * infant \<12 months * 18 years or older * epds score \>10 exclusion criteria: -

Keywords: cognitive therapy workshop postpartum depression
treatment response evaluation in gastrointestinal stromal tumor (gist) patients

Conditions: Soft Tissue Neoplasms; Gastrointestinal Tract

Summary: the purpose of this study is to compare sensitivity, specificity and accuracy of pet, dw mri and ct separately and combined for the evaluation of treatment response and progression-free survival in patients with gist.


Eligibility criteria:
inclusion criteria: * metastatic gist patients suitable for tki treatment * gist patients pursuing preoperative neoadjuvant tki treatment exclusion criteria: * patients with contraindications to mri and/or tki treatment. for patients with renal failure, ct without intravenous contrast will be performed according to clinical practice. * patients who do not sign the consent paper for any reason or do not accept the study premises or patients who wish to withdraw for any reason during the study

Keywords: gist response monitoring functional magnetic imaging positron emission tomography computer tomography
effectiviteit en beleving van foodiyou

Conditions: Obesity

Summary: studies have shown that personalized nutrition advice is more effective compared to generic nutrition advice for weight loss purposes. however, since decentralization of clinical trials is on the rise, it of interest to test whether personalized nutrition advice is as effective when provided fully digitally. in the current study the investigators compare the effects of generic vs. personal nutritional interventions in a fully digital study. three groups are included, a control group receiving generic nutritional advice, an intervention group receiving personalized nutrition advice and an intervention plus group receiving personalized nutrition advice plus personalized meals. the trial takes six weeks. anthropometric data are collected every two weeks and data on changes in nutritional diet are collected at the beginning and end of the intervention. in addition, the opinion of the participants on trial participation is asked as well every two weeks during the trial.


Eligibility criteria:
inclusion criteria: * age between 25-60 years * bmi between 25 and 40 * motivated to lose weight * can fill in a digital questionnaire * posses a smartphone, computer, weighing scale and measuring tape to perform anthropometric measurements. exclusion criteria: * any food allergy * chronic diseases influencing food intake (e.g., ibd) * participating in another intervention study * females in menopausal transition * follow a specific diet

Keywords: digital studies personalized nutrition
out-of-hospital resuscitation in winterthur - an outcome study

Conditions: Resuscitation

Summary: the investigators will retrospectively examine all patients with out-of-hospital resuscitation by the emergency medical team (emt) from the kantonsspital winterthur in the year 2013 with a two year follow-up and a structured interview about quality of life. furthermore, the costs generated by the local health system are analysed.

the primary objective of this study is to evaluate the quality of out-of-hospital resuscitation by the ambulance service from the kantonsspital winterthur including a 2-year follow-up of the survivors. in this follow-up we evaluate the quality of life by a validated questionnaire. the following endpoints will be retrospectively analysed: time-to-response interval; initial cardiac rhythm; medications given; number of defibrillations; return of spontaneous circulation, overall costs for the local health system furthermore length of hospital-stay, survival until hospital discharge, one-year survival, quality of life two years after resuscitation and total costs will be analysed.

Eligibility criteria:
inclusion criteria: * patients with out-of-hospital resuscitation in winterthur in the year 2013 and treatment by the emergency medical team from the kantonsspital winterthur * written informed consent of patients for structured interview exclusion criteria: * patients with resuscitation but death on scene * no written informed consent from patients for structured interview

Keywords: resuscitation, quality of life
plant-based nutrition for patients with cardiovascular risk factors

Conditions: Metabolic Syndrome; Cardiovascular Risk Factor; Overweight and Obesity; Hypertension,Essential

Summary: plant-based nutrition may have positive effects on chronic diseases such as cardiovascular or metabolic disorders. this study investigates the effects of a 8 week plant-based diet for patients with metabolic syndrom and cardiovascular risk factors.


Eligibility criteria:
inclusion criteria: * blood pressure \> 140 mmhg systolic and/or \> 90 mmhg diastolic, in case of medication also increased values \> 140 mmhg systolic and/or \> 90 mmhg diastolic needed * adipositas with a waist circumference of \> 94 cm in men and \> 80 cm in women * a non-vegetarian diet in the past 6 months (at least 4x meat and/or meat products per week, at least 5x dairy products per week) * no fasting, no specific diet or change of diet in the last 2 months * weight stable over the last two months (+- 3 kg) * medication unchanged for at least one month * no fasting, no change of diet in the last 2 months exclusion criteria: * poor general condition * coronary heart disease * diabetes mellitus type i * cerebrovascular diseases * severe mental illness * severe acute or chronic comorbidity * pregnancy and lactation or planned pregnancy in the next 6 months * eating disorder * max. 2 beers 0,5l or 2 wines 0,2l per day * no alcohol abstinence 48 hours before blood samples possible * max. 5 cigarettes/day * medicine that affect weight * antibiotics within the last 6 months * major surgery \<6 months prior to randomization * bmi \> 40 kg/m2 * existing vegetarian or plant-based diet * bariatric surgery (obesity surgery) * simultaneous participation in another clinical trial * participation in a clinical trial within the last 3 months prior to inclusion in the study * lack of consent to participate in the study

Keywords: metabolic syndrom plant-based diet nutrition
azd5423 single ascending dose study

Conditions: Healthy Volunteers

Summary: the aim of the study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of azd5423 following single ascending dose administrations in healthy male subjects.


Eligibility criteria:
inclusion criteria: * provision of signed, written and dated informed consent prior to any study specific procedures * have a body mass index (bmi) between 18 and 30 kg/m2 and weigh at least 50 kg and no more than 100 kg exclusion criteria: * any clinically significant disease or disorder * any clinically significant abnormalities at screening examination * use of any prescribed or non-prescribed medication

Keywords: safety tolerability healthy inhalation
demand - multifactorial study to reduce dementia in people with type 2 diabetes

Conditions: Type 2 Diabetes Mellitus; Mild Cognitive Impairment

Summary: in the demand pilot study, we will recruit and randomize 80 participants at two study sites (umeå and uppsala) for a one-year intervention. the primary objectives are to study the inclusion rate, the adherence rate, and the acceptability of the intervention. the secondary objectives are to examine the effect of the intervention on intermediate outcomes, including metabolic control (i.e., blood glucose and lipids), body weight, blood pressure, physical fitness, and cognitive function. third, the investigators will perform focus group interviews to explore the participants views on the intervention to assess the acceptability. the interventions include (a) mediterranean diet (b) an individualized physical training program and (c) pharmacological treatment for type 2 diabetes (t2d) aimed to achieve individualized optimal goals, according to national guidelines, taking into account the risk of hypoglycaemia. this multi-component intervention is more comprehensive than usual care, and it specifically focuses on vascular domains.

to be inserted.

Eligibility criteria:
inclusion criteria: * type 2 diabetes diagnosed in the last year * age \>=65 years * signed consent form * mild cognitive impairment exclusion criteria: * diagnosis type 1 diabetes * major neurocognitive degeneration * serious illness with live expectancy less than 3 years * drug- or alcohol-abuse or other neurological / psychiatric illness which affects the outcome * depressive syndrome * predicted inability to conduct the study because of drug abuse, serious illness, language issues * documented episodes of hypoglycemia where help of a third part was needed * allergy to fish or nuts * angina pectoris * heart failure (nyha 3-4)

Keywords: mediterranean diet physical fitness
effect of selenium supplementation on influenza vaccination

Conditions: Selenium Supplementation; Influenza Vaccination

Summary: the study is designed to assess whether selenium supplementation can boost the immunity response to influenza vaccination in healthy adults. this is a randomized, prospective study enrolling a total of 60 healthy subjects, 18-55 years old.

background: selenium is an essential trace element required for human health and wellbeing. despite mouse studies and human clinical trial suggest selenium supplementation might enhance immunity, little is known for the effects of selenium supplementation on humoral immunity. vaccination is the most effective medical intervention to prevent infections and to reduce disability and mortality associated with infectious disease. however, some individuals, in healthy or disease conditions, mount less effective humoral immune responses to vaccination. therefore, new strategy to enhance humoral immunity upon vaccination is highly sought after. using mouse models, we have observed that selenium supplementation significantly increased antigen-specific antibody responses. thus, we hypothesize that selenium supplementation may be beneficial in enhancing humoral immunity in humans. objectives: to investigate whether selenium supplementation will boost the humoral response to influenza vaccination in healthy adults. design and trial size: this is a randomized prospective study. a total of 60 healthy subjects, 18-55 years old, will be enrolled in this study. intervention and duration: the enrolled subjects will be randomized into selenium supplementation and control group. the selenium supplementation group will receive 200 μg selenium daily by taking two selenium-enriched yeast tablets (selenoprecise®, pharma nord) once daily for 60 days. the control group will not receive selenium supplementation. thirty days after allocation, both groups will receive standard seasonal influenza vaccination for the 2019-2020 season. peripheral blood samples will be collected at baseline (day 0, prior to treatment), day 30, day 37 (7 days after vaccination) and day 60 (30 days after vaccination).

Eligibility criteria:
inclusion criteria: 18-55 years, healthy subjects exclusion criteria: 1. with the history of selenium supplementation as taking supplementation products or living more than 2 years in selenium-enriched area; 2. had the symptoms of selenium toxicity or serum selenium level greater than 328 μg/l; 3. with the history of the administration of influenza vaccine in past three years or allergic to influenza vaccine; 4. with any current immunologic disorders, including autoimmune and allergic diseases; 5. with any cardiovascular, metabolic, mental, or psychological disorders; 6. pregnancy or breastfeeding; 7. with the history of infectious diseases including airway infections in past three months; 8. who are currently participating in other clinical studies or who have participated in other clinical research within 90 days
p6 acupressure before laparoscopic cholecystectomy

Conditions: Postoperative Complications; Postoperative Nausea and Vomiting

Summary: this study is to evaluate the effect of preoperative acupressure application on postoperative nausea and vomiting (ponv) in patients undergoing laparoscopic cholecystectomy in terms of being in high risk group for ponv.

prevention of postoperative complications is one of the main tasks of nurses. however, there are limited nursing interventions that can be done to prevent ponv. the american society of perianesthesia nurses suggest nurses to teach patients with a high risk of ponv about acupressure application on p6 acupoint or to apply acupressure wristbands preoperatively. however this suggestion has a low evidence.

Eligibility criteria:
inclusion criteria: * patient undergoing elective laparoscopic cholecystectomy * patients who make their admission the day before surgery * patients with american society of anesthesiologists (asa) physical status classification system i and ii * patient who gave written consent to participate in the study exclusion criteria: * patient who undergone urgent laparoscopic cholecystectomy * patients who make their admission on the day of surgery * patients with who do not conform physical status of asa i and ii * patients who loss single or both upper extremity * patients with open wounds, scar tissue or infection on wrist in acupressure application area

Keywords: acupressure perioperative care postoperative nausea and vomiting nursing care management
multi-domain psychoeducation self-management program for adults with mdd in singapore

Conditions: Major Depressive Disorder

Summary: this is a single-centre, two-arm, unblinded pilot randomised controlled trial study on 60 participants (30 in each arm) from the community mental health service (cmhs) centre within a social service agency in singapore based on inclusion criteria. the study will examine the effects of a 5-sessions of multi-domain psychoeducation self-management programme and treatment-as-usual) over 5 weeks or control (treatment-as-usual) group.

this is a single-centre, two-arm, unblinded pilot randomised controlled trial study. a total of 60 participants (30 in each arm) will be conveniently recruited from the community mental health service (cmhs) centre within a social service agency in singapore based on inclusion criteria. block randomisation with a block size of two will be used to randomise participants into the intervention (5-sessions of multi-domain psychoeducation self-management programme and treatment-as-usual) over 5 weeks or control (treatment-as-usual) group. primary outcomes measures which include self-management competence, self-efficacy to manage emotions, mental health quality of life and depressive symptoms severity, will be collected at three timepoints: (t1) baseline, (t2) immediately post-intervention and (t3) three months post-intervention. quantitative data will be analysed using the statistical package for social sciences (spss) software using non-parametric tests. secondary outcomes include the feasibility and acceptability of the mpsp. feasibility of the intervention will be evaluated using pre-defined recruitment, attendance and follow-up rates. acceptability of the intervention will be evaluated using a semi-structured interview guide based on the theoretical framework of acceptability, immediately post-intervention (t2) or not more than a week from the last session. data for acceptability will be transcribed verbatim and thematically analysed based on braun and clarke's thematic analysis guideline.

Eligibility criteria:
inclusion criteria: * clinically diagnosed with major depressive disorder * community-dwelling adults aged 21 to 80 years old * singaporean or permanent residents * literate in the english language * willing to be video or audio-recorded during the qualitative interview sessions for acceptability of intervention exclusion criteria: * clinically diagnosed with maternal depression * clinically diagnosed with cognitive impairment/ intellectual disability * pregnant women * currently institutionalised in a long-term care facility * currently attending other psychoeducation self-management programmes * those who do not agree to the audio or video recording.

Keywords: major depressive disorder community dwelling adults
adherence to guidelines for antibiotic use in respiratory infections at hospitals

Conditions: Pneumonia; Chronic Bronchitis; COPD

Summary: the purpose of this study is to test a strategy to improve the quality of antibiotic use in lower respiratory tract infections (lrtis) at hospitals. therefore, a multifaceted intervention strategy is compared to a control strategy and the effectiveness and feasibility of the intervention is assessed.

improving processes of care in patients with hospital lrti has been related to better patient outcome. inappropriate use of antibiotics has contributed to the emergence and spread of drug-resistant micro organisms and increased treatment costs. international guidelines provide recommendations for the initial evaluation and management of lrti, including advice on judicious antibiotic therapy. nonetheless, studies have demonstrated a wide variability in adherence to these guidelines. to implement key recommendations in clinical practice, various strategies have been used, with mixed results. perhaps the most important aspect of choosing a potentially effective intervention is that the choice of intervention should be based upon assessment of potential barriers in the target group. many intervention studies are flawed by failing to control for secular trends. the investigators performed a cluster randomised controlled trial, to study the effect of a multifaceted intervention strategy on the quality of antibiotic use for lrti. their intervention was tailored to the areas most in need for improvement and took perceived barriers in the target group into consideration at the individual hospital level.

Eligibility criteria:
inclusion criteria: * patients admitted to a respiratory care or internal medicine ward with community-acquired pneumonia or acute exacerbation of chronic bronchitis or chronic obstructive pulmonary disease (copd) exclusion criteria: * recent (\< 30 days) admission for lrti * patients with underlying immunodeficiency (hiv infection, neutropenia, treatment with immunomodulating drugs, active hematological malignancies, anatomical or functional asplenia and hypogammaglobulinemia) * patients already on treatment with antibiotics for another culture proven infection at the time of admission * patients from nursing homes * patients who had been transferred to another hospital or icu and patients who had died within 24 hours of admission * patients with very poor prognosis (life expectancy \< 2 weeks on admission).

Keywords: quality of care antibiotic use intervention lower respiratory tract infections community acquired pneumonia acute exacerbation of chronic bronchitis or copd