Kornimate/medical-research-clean huggingface dataset:
effectiveness of eccentric and concentric strength training in patients with subacromial impingement syndrome

Conditions: Subacromial Impingement Syndrome

Summary: the purpose of this study is to investigate and compare the effects of eccentric and concentric strength training on pain, strength, joint position sense and function in patients with subacromial impingement syndrome.


Eligibility criteria:
inclusion criteria: * diagnosis of subacromial impingement syndrome * complaints associated with subacromial impingement syndrome for at least 3 months * no extra pain with 90 degree abduction-90 degree external rotation position of the shoulder * ability to complete the entire study procedure exclusion criteria: * severe pain; shoulder pain is \> 7/10 * history of upper extremity fracture * history of shoulder, cervical and thoracic surgery * having shoulder instability or frozen shoulder diagnosis * history of shoulder injuries, trauma and / or shoulder symptoms requiring treatment during the last 1 year (except than subacromial impingement syndrome) * full-thickness rotator cuff tear * systemic musculoskeletal disease * neck and shoulder pain with cervical spine movement * chest deformity or scoliosis diagnosis
cardiosideral heart surgery: randomized study on sucrosomial iron supplementation before heart surgery

Conditions: Anemia

Summary: this randomized, single blind (outcomes assessor), non-profit study is aimed at verifying whether routine preoperative supplementation with sucrosomial® iron in patients scheduled for cardiac surgery may increase baseline haemoglobin, constrain the haemoglobin decrease between postoperative day 2 and 3 (haemoglobin drift), and reduce the postoperative transfusion requirements, in order to identify a new strategy for pre-hospitalization optimization and post-operative recovery.

this randomized, single blind (outcomes assessor), non-profit study is aimed at verifying whether routine preoperative supplementation with sucrosomial® iron in patients scheduled for cardiac surgery may increase baseline haemoglobin, constrain the haemoglobin decrease between postoperative day 2 and 3 (haemoglobin drift), and reduce the postoperative transfusion requirements, in order to identify a new strategy for pre-hospitalization optimization and post-operative recovery. secondary objectives are * changes in blood chemistry and biochemical tests between pre- and post-intervention * evaluation of tolerability and compliance of supplementation with sucrosomal iron * reduction in the number of transfusions and blood bags used * evaluation of cost-effectiveness

Eligibility criteria:
inclusion criteria: undergoing elective heart surgery - exclusion criteria: - emergent or urgent indication

Keywords: anemia heart surgery iron supplementation
mother-infant rapid intervention at delivery telephone outreach for neonatal therapy (tot) trial.

Conditions: HIV

Summary: the telephone outreach for therapy trial was designed to test an intervention to assist new mothers or caregivers of hiv-exposed children with administering medication for the first 6 weeks of life to prevent mother-to-child hiv infection in the infants. to be eligible, mothers of infants were identified as hiv-infected in the mother-infant rapid intervention at delivery study. mothers or caregivers of infants were randomized into two groups: the intervention group received a cellular phone and scheduled twice daily calls to assure infant medications were given, and the other group received the current standard of care. enrollment into the study was completed and analysis of the study data is underway.

the telephone outreach for therapy trial was designed to test an intervention to assist new mothers or caregivers of hiv-exposed children with administering medication for the first 6 weeks of life to prevent mother-to-child hiv infection in the infants. to be eligible, mothers of infants were identified as hiv-infected in the mother-infant rapid intervention at delivery study. mothers or caregivers of infants were randomized into two groups: the intervention group received a cellular phone and scheduled twice daily calls to assure infant medications were given, and the other group received the current standard of care. enrollment into the study was completed and analysis of the study data is underway.

Eligibility criteria:
inclusion criteria: * mother-infant pairs in which the mother was identified as hiv-infected in the miriad study exclusion criteria: * mother-infant pairs in which the infant is expected to be hospitalized for \>2weeks after birth
hispanic men building respect education and safety/ hombres manteniendo respeto, educacion y seguridad.

Conditions: Substance Abuse; Domestic Violence; HIV/AIDS

Summary: the overall objective of this project is to adapt and enhance hombres (hispanic men building respect, education, and safety within families /hombres manteniendo respeto, educacion y seguridad de familia), a center for disease control (cdc)-identified best-evidence hiv behavioral intervention designed to reduce substance abuse, family violence, and hiv/aids (sava) among sexually active heterosexual latino seasonal farmworkers (lsfws) in rural areas.

the hombres de familia project study (hombres) examined the efficacy of a culturally adapted group intervention program with fathers from a seasonal farm working community and an urban community in south florida. the hombres intervention study adapted and tested the efficacy of an intervention that can be adopted, implemented, and sustained with latino fathers who live or work in the farm industry, construction, services, self employed or any other work industry in the semi-rural areas and urban areas of miami dade county. the hombres intervention seeked to reduce risk for the sava (substance abuse, violence, and hiv/aids infection) syndemic among this group of men and their adolescent sons. the intervention hombres consisted of four sessions remotely facilitated via a well-tested video platform accessible by a link sent to the participants' telephone, computer, tablet or ipad (approximately 1.5 hours each session). staff scheduled the times when participants will watch the videotaped sessions in order to be available for their questions. intervention videos were followed up with a telephone call to discuss presentation and respond to any questions participants may have had about the sessions and clarify (if needed) the material covered in the videos via telephone. video sessions were completed within two weeks time period. participants in the control group received one single video on diabetes prevention. both groups were followed up six months post baseline interview.

Eligibility criteria:
inclusion criteria: * male * adults (age 18 or above) * living in semirural and urban areas of miami dade * latino * understand and speaks spanish * has an eligible son ( 11-17 years old) exclusion criteria: * father does not provide consent and permission for his son * son does not provide assent

Keywords: family violence hispanic/latino health disparities migrant farmworkers
vitamin d supplement study for adolescents

Conditions: Vitamin D Deficiency; Overweight; Obesity

Summary: the purpose of this study is to determine if 14-19 year old african american adolescents are able to take a daily vitamin d supplement daily for about 4 months and how well a daily dose of 400 iu or 2000 iu vitamin d supplement raises their vitamin d blood level.

to determine the feasibility of african american teenagers taking a daily vitamin d supplement over a 4 month period in terms of compliance and practical implementation. to determine the differences in response in blood 25-oh d level between those randomly assigned to taking a 400 iu supplement versus 2000 iu per day and to determine if there are differences in blood 25-oh d level response depending on subject gender and overweight/obese versus healthy-weight status.

Eligibility criteria:
inclusion criteria: * healthy african american adolescents exclusion criteria: * hypertension * pregnancy * medications that affect study outcome measures * use of other vitamin and/or mineral supplement or herbal supplements * individuals of other races

Keywords: vitamin d deficiency adolescents african americans overweight obesity
evaluating the effectiveness of interactive sms reminders on tb treatment outcomes

Conditions: Tuberculosis

Summary: in this study, interactive research and development (ird) in karachi, pakistan is evaluating the impact of interactive reminders on drug compliance and treatment outcomes. interactive reminders is an interactive sms reminder system to help patients remember to take their tb medication. in this system, patients receive daily sms reminders for the duration of their treatment at a pre-specified time, reminding them to take their medication. patients are asked to reply back to the system, either through sms or a missed call, with the time they took their medicine that day. if a response is not received within two hours, a second reminder is sent. if a response is still not received in a further two hours, a third and final reminder for the day is sent. non-responsive patients are followed up with phone calls and a list of non-responsive patients is shared with clinics based on the parameters of non-responsiveness that they specify. ird seeks to determine the impact of this system on treatment outcomes and compliance to prescribed medication through administering a randomized control trial among newly diagnosed tb patients in karachi, pakistan.


Eligibility criteria:
inclusion criteria: * new, smear-positive drug susceptible tb who have been on treatment for less than two weeks * access to a mobile phone (self-reported) * intending to reside in karachi for the duration of their treatment exclusion criteria: * patients who do not have regular access to a mobile phone * patients who have previously received tb treatment * patients who have another member in their household who is already a part of the study

Keywords: sms tuberculosis impact evaluation
standard care with lllt & myofascial release versus standard care alone in pregnant women with temporomandibular disorder

Conditions: Temporomandibular Disorder

Summary: this study will investigate a novel approach to treat pregnant women with tempromandibular disorder using a combined method of low level laser therapy, myofascial release and standard care versus standard care alone. it's hopeful that the results of this study can fill the gap of knowledge surrounding the conservative treatment options for tmd in order to help patients restore their oral function properly and promote new ways of addressing tmd.


Eligibility criteria:
inclusion criteria: * pregnant women diagnosed with myofascial tmd according to the research diagnostic criteria for temporomandibular disorders exclusion criteria: * facial neuro-musculoskeletal pathologies (i.e., facial trauma and/or fractures, and bell's palsy) * acute infections or systemic disorders * osteoporosis * cervical spine or upper limb dysfunction * steroid infiltration4 * any recent dental treatment taken or surgery over tmj * hypermobile joint * neurological impairments
x-linked hypophosphatemia and fgf21

Conditions: X-linked Hypophosphatemia

Summary: fibroblast growth factor 23 and fibroblast growth factor 21 are two endocrine fibroblast growth factors, requiring klotho as a co-factor to promote their systemic actions. fibroblast growth factor 21 is involved in the regulation of glucid and lipid metabolism. fibroblast growth factor 21 knock out mice display obesity and hyperglycemia. in investigators experience, patients with x-linked hypophosphatemia often present with early-onset over-weight that could be partly explained by decreased physical activity because of bone pains and deformations after puberty; however, patients usually display progressive over-weight earlier in life, when there is no limitation of physical activity yet. to the knowledge of investigators the association between fibroblast growth factor 23, fibroblast growth factor 21 and klotho in patients with x-linked hypophosphatemia has never been evaluated. thus, the main objective of this study is to evaluate the glucid and lipid metabolism in patients with x-linked hypophosphatemia, the main working hypothesis being that the genetic deregulation in the fibroblast growth factor 23 axis in patients with x-linked hypophosphatemia induces modifications of klotho levels (namely decreased levels) that in turn will deregulate the fibroblast growth factor 21 axis (resistance to fibroblast growth factor 21 because of decreased klotho levels).


Eligibility criteria:
inclusion criteria: * child with x-linked hypophosphatemia with phex gene mutation * child between 10 and 18 years old * child over 10 kg having a blood sample as part of the treatment (due to regulatory constraints for blood volume taken in 30-day period of 40 ml in children over 10 kg) * child and parent / holder of parental authority who has been informed of the study and does not object to participate. exclusion criteria: - pregnancy in progress
walking away: structured education versus written information for individuals with high risk of developing type 2 diabetes

Conditions: Diabetes

Summary: diabetes is a debilitating chronic disease reaching epidemic proportions. lack of physical activity is a key factor driving this epidemic and it is therefore vital that workable methods of encouraging people to exercise and reducing inactivity are developed and tested if we are to stem the rising tide of diabetes. this cluster randomised controlled trial will investigate whether a person-centred group educational programme can increase walking activity and reduce the risk of developing diabetes in high-risk individuals identified in primary care settings. in total 804 patients will be recruited to the study. physical activity levels, glucose control, incidence of type 2 diabetes and anthropometric measurements (e.g. weight) will be tested on an annual basis over three years. this trial will be the first to test the feasibility, efficacy and value for money of a physical activity intervention aimed at reducing the risk of diabetes in a community setting in a multi-ethnic population in the uk. primary research hypothesis: a pragmatic structured education programme aimed at promoting walking activity initiates long-term increases in physical activity in individuals identified through a risk score as having an increased risk of developing type 2 diabetes.


Eligibility criteria:
inclusion criteria: * 18+ * high risk of developing type 2 diabetes as identified through a risk score exclusion criteria: * diagnosed diabetes * taking steroid medication * serious chronic illness preventing participation in trial * unable to speak english

Keywords: physical activity diabetes prevention pedometer walking structured education randomized risk score impaired glucose regulation
immunobiology of diabetes and tuberculosis

Conditions: Tuberculosis; Diabetes Mellitus

Summary: the study hypothesis is that type 2 diabetics have abnormal cell-mediated immunity to tuberculosis manifesting as altered cytokine responses by peripheral blood mononuclear cells (pbmcs). this hypothesis will be tested using the live tuberculosis vaccine, bacille calmette-guerin (bcg), in u.s.-born type 2 diabetics and nondiabetics. the investigators will control for potential confounding by age, sex, race, comorbidities, and select medications. expression of key cytokines will be measured with real-time polymerase chain reaction.

the project has three specific aims: specific aim 1: to assess differences between the study groups in cytokine expression before and after bcg vaccination. the investigators will determine within-individual variability in cytokine measurements and describe the kinetics of cytokine response to bcg. peak response levels, time to peak, and patterns of cytokines expressed will be compared. specific aim 2: to evaluate the effect of hyperglycemia on the cytokine response of type 2 diabetics. the investigators will evaluate whether levels of hemoglobin a1c (hba1c) are associated with degree of cytokine response and test if type 2 diabetics who have good glucose control are different from nondiabetics. specific aim 3: to evaluate the effect of testing pbmcs from diabetics outside of their diabetic milieu. investigators will compare the bcg-specific cytokine responses of pbmcs stimulated in normal medium, pbmcs stimulated in glucose correlating to the person's most recent hba1c, and whole blood samples.

Eligibility criteria:
inclusion criteria:type 2 diabetes or healthy individual able to give consent us-born age 30-65 exclusion criteria:\* immunosuppressive disease * immunosuppressive medications * pregnancy * renal failure * advanced pulmonary disease * prior bcg vaccination * prior tb infection * type 1 diabetes
acute ischemic stroke registry for endovascular treatment

Conditions: Acute Ischemic Stroke

Summary: the acute ischemic stroke registry for endovascular treatment (ais-evt) is an academic, prospective, multicenter, observational registry study. consecutive stroke patients treated with endovascular treatment will be enrolled in stroke centers. baseline information and clinical follow-up information at 90 days of stroke onset are collected. data collected include demographics, comorbidities, pathogenesis, blood pressures, stroke severity on admission, time intervals, reperfusion condition, and functional outcome, et al.


Eligibility criteria:
inclusion criteria: 1. diagnosis of acute ischemic stroke; 2. imaging confirmed intracranial large vessel occlusion: intracranial internal carotid artery (ica), middle cerebral artery (mca m1/m2), anterior cerebral artery (aca a1/a2), basilar artery (ba), vertebral artery (va v4), and posterior cerebral artery (pca p1); 3. initiation of any type of endovascular treatment, including intra-arterial thrombolysis, mechanical thrombectomy, aspiration, angioplasty, and stenting; 4. verbal and written informed consent was provided at the time of admission by patients or their legal authorized representatives. exclusion criteria: no evidence of large vessel occlusion on digital subtraction angiography.

Keywords: acute ischemic stroke endovascular treatment outcome registry
efficacy of diode laser in peri-implantitis

Conditions: Implant; Peri-Implantitis; Alveolar Bone Loss; Complications

Summary: the aim of this study was to compare the efficacy of a diode laser (dl) as an adjunct to conventional scaling in the treatment of mild-to-moderate peri-implantitis. a prospective clinical, radiographic and microbiologic split-mouth study was conducted to test the following null hypothesis; adjunct application of a diode laser, in the conventional treatment of peri-implantitis, are not associated with a statistically significant difference regarding the microbial counts, marginal bone loss and peri-implant parameters.

efficacy of a diode laser (dl) in peri-implantitis was investigated. 48 implants diagnosed with peri-implantitis were included. in addition to the conventional scaling and debridement, random 24 implants were lased by a dl. periodontal indexes, microbiologic specimens and radiographs were used for assessment. baseline parameters were similar between groups. after six months laser group revealed higher mbl than the control group. microbiota of the implants were found unchanged after one month. dl appears to have no additional positive influence on the peri-implantitis treatment.

Eligibility criteria:
inclusion criteria: * 18 years and older * no local and systemic health problems prohibit the study interventions * bi-lateral implants with peri-implantitis diagnosis exclusion criteria: * local and systemic health problems prohibiting the study interventions

Keywords: dental implant laser diode laser peri-implantitis bacterial count
fluoride in saliva after use of fluoride toothpastes followed by fluoride mouthrinses

Conditions: Dental Caries

Summary: this study will evaluate fluoride (f) bioavailability in saliva when using an over-the-counter mouthrinse of 226 ppm f, immediately after brushing with an over-the-counter toothpaste of 1,100 ppm f or a prescription toothpaste of 5,000 ppm f. the study population will include twenty individuals, over the age of 18 years-old, from both genders, with normal oral health conditions and salivary flow rate, no need of urgent dental needs, from the ann arbor, mi area. participants will be recruited from the university of michigan school of dentistry, in ann arbor, mi. using a crossover design, twenty participants will be rotating through 4 different combinations of fluoride toothpaste (over-the-counter or prescription concentration) and fluoride mouth rinse (yes or no), in a 2 x 2 factorial design. treatments to be tested will be as followed: group #1 will brush with 1,100 ppm f (over-the-counter) toothpaste; group #2 will brush with 1,100 ppm f (over-the-counter) toothpaste and rinse with over-the-counter 226 ppm f mouthrinse; group #3 will brush with 5,000 ppm f (prescription) toothpaste; group #4 will brush with 5,000 ppm f (prescription) toothpaste and rinse with over-the-counter 226 ppm f mouthrinse.


Eligibility criteria:
inclusion criteria: * sign informed consent form * participant understands and agrees to comply with the study protocol, and confirms availability for the entire duration of the study * 18 years of age or older * good general health * good oral health, with no urgent treatment needs * normal salivary flow rate exclusion criteria: * fail to understand or to agree to follow the study protocol * reduced salivary flow rate * poor general or oral health conditions
single complete compression ultrasonography to rule out deep vein thrombosis during pregnancy and postpartum

Conditions: Deep Vein Thrombosis

Summary: the objective of the edvige study is to determine whether a negative single distal and proximal leg veins compression ultrasonography safely rules out the diagnosis of deep vein thrombosis in pregnant and post-partum women with clinical suspicion of dvt.

a single distal and proximal leg veins compression ultrasonography has been shown to safely rule out the diagnosis of dvt when negative. the safety of this strategy has never been verified in pregnant or postpartum women. it could however be limited in that clinical setting, because of modified hemodynamics, hampered observation conditions, lack of respiratory modulation, higher proportion of isolated iliac deep vein thromboses. the objective of the edvige study is to assess the safety of this diagnostic strategy during pregnancy and post-partum.

Eligibility criteria:
inclusion criteria: * women with an ongoing pregnancy or within three-months post-partum and a clinically suspected deep vein thrombosis exclusion criteria: * suspicion of pulmonary embolism * age less than 18 years * impossible follow-up

Keywords: pregnancy postpartum deep vein thrombosis venous thromboembolism diagnosis compression ultrasonography