Kornimate/medical-research-clean huggingface dataset:
effect of early mobilization on length of stay, recovery and readmission rate of patients after cabg or avr/mvr surgery

Conditions: Coronary Artery Disease; Aortic Valve Disease; Mitral Valve Disease

Summary: the present study will investigate the volume and extent of the expected physiological effects of "early mobilization" on the prevention of the clinical illness' detrimental sequelae and on the functional recovery promotion of cabg, avr and mvr patients. consequently, it will investigate if the improved health outcomes may limit the number and intensity of complications and thus if it may speed up hospital discharge.

although the effects of "early mobilization" have been studied mainly in the intensive care unit setting, the findings could be applied to the surgical units' patients too, since they share common physiological and clinical characteristics. in the literature the effectiveness of "early mobilization" in the length of hospital stay and recovery of the patients operated for coronary artery bypass graft and heart valve replacement in the cardiac surgery setting, is unknown. the term "early mobilization" is not restricted to a time factor procedure but contains the provision of a customized dynamic set of physical therapy techniques which in studies are variably determined in terms of duration, intensity, frequency and content. the aim of the study is to determine the clinical effectiveness of the intensive early mobilization physical therapy intervention compared with standard care of physical therapy in the cardio-thoracic surgery clinic of papageorgiou general hospital of thessaloniki. the present study will investigate the volume and extend of the expected physiological effects of "early mobilization" on the prevention of the clinical illness' detrimental sequelae and on the functional recovery promotion, hospital mortality and readmission rate of cabg, avr and mvr patients. consequently, it will investigate if the improved health outcomes may limit the number and intensity of complications and thus may speed up hospital discharge. in the first group of the experimental design, patients will be treated with an intensive early mobilization protocol and the patients of the second group will receive a standard care physical therapy treatment. controlling for the detailed baseline characteristics that will be assessed during medical history at admission, potential bias will be limited from unmeasured confounders of the study.

Eligibility criteria:
inclusion criteria: * elective cabg or avr or mvr surgery * no previous cabg or valve surgery * isolated / multivessel cabg exclusion criteria: * current neurological disorders * previous cerebral vascular accident with residual neurological deficit significant enough to limit exercise * significant limiting comorbidities that would prevent full participation
biomarkers and perfusion - training-induced changes after stroke

Conditions: Stroke

Summary: the purpose of this observational study is to examine the effects of 4-weeks of physical fitness training in patients with subacute ischemic stroke on cerebral imaging and blood-derived biomarkers.

this biomarker-driven study uses an observational design to examine a subgroup of patients in the randomized, controlled trial "physical fitness training in subacute stroke" (phys-stroke). in phys-stroke, 215 patients with subacute stroke (hemorrhagic and ischemic) receive either 4-weeks of physical training (aerobic training, 5 times a week, for 50 minutes) or 4-weeks of relaxation sessions (5 times a week, for 50 minutes). a convenience sample of 100 of these patients with ischemic stroke will be included in baptise and will receive magnetic resonance imaging (mri) scans and blood tests before and after the phys-stroke intervention. imaging scans will address parameters of cerebral perfusion and vessel size imaging. blood tests will determine several parameters such as immunity, inflammation (including neopterin, mmp-9), metabolism (including apociii, oxidized ldl, homa-index, uric acid, ck-mb, cystatin c, and leptin), cytokines (osteopontin, adiponectin), and endothelial function (sdf1-alpha, adma, sicam, svcam, e-selectin, p-selectin). additionally, we will assess the association between functional outcomes (co-primary outcome measures of phys-stroke) and biomarkers including imaging results.

Eligibility criteria:
inclusion criteria: * age: \> 18 years * diagnosis of subacute ischemic stroke (within 5-45 days after stroke onset)as determined by initial mri/ct scan of the brain * cortical, sub-cortical, or brainstem affection * barthel index (bi) \<65 at inclusion * able to sit for at least 30 seconds (unsupported or supported, i.e., holding onto supports such as the edge of the bed) * ability to perform aerobic exercise, determined by by responsible physician * provision of written informed consent exclusion criteria: * lacking ability to comply with study requirements * stroke due to intracranial haemorrhage * previous subarachnoid hemorrhage or other hemorrhagic stroke * progressive stroke * not able to receive magnetic resonance imaging scans, including perfusion imaging * unable to perform the required exercises due to medical, musculoskeletal, or neurological problems * required help of at least 1 person to walk before stroke due to neurological (e. g., advanced parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis) or non-neurological co-morbidities (e. g. heart failure, orthopaedic problems) * life expectancy \< 1 year as determined by responsible physician * drug or alcohol addiction within the last six months * significant current psychiatric illness defined as medication-refractory of bipolar affective disorder, psychosis, schizophrenia or suicidality * current participation in another interventional trial

Keywords: physical fitness relaxation stroke cerebral ischemia cerebral perfusion biomarkers mri
cold therapy for pediatric appendectomy

Conditions: Appendicitis

Summary: this is a randomized control trial to evaluate the efficacy of an fda approved cold therapy device vs. usual care among children undergoing appendectomy at a large children's hospital.


Eligibility criteria:
inclusion criteria: * age of 7 years of older * diagnosis of appendicitis and scheduled appendectomy exclusion criteria: * neurologic and decision impairment * chronic opioid dependency * planned icu admission post-operatively * reoperation during hospital stay * ward of the state * non-english and non-spanish speakers
endoscopic posterior mesorectal resection in t1 rectal cancer

Conditions: Rectal Neoplasms

Summary: any efforts to spare patients with t1 carcinomas of the rectum from low anterior resection or even abdominoperineal resection are linked to the risk of locoregional recurrence of about 10% (range, 0-24). this is tolerated in the view of the morbidity and mortality risk related to transabdominal resection, which is as high as 7-68% and 0-6.5%, respectively. accordingly, in addition to transanal local excision various adjuvant therapy schemes with chemo- and/or radiotherapy were developed, given the uncertainty about the lymph node stage. another approach was to identify histological risk criteria in the primary tumor in terms of defining the limits of rectum-sparing therapy. in earlier experimental and clinical studies the investigators researched and applied dorsoposterior extraperitoneal pelviscopy, i.e. perineal access to the soft-tissue areas of the minor pelvis using minimally invasive surgery. in t1 carcinoma of the rectum this technique becomes all the more significant, as the perineal approach makes it possible to perform an endoscopic posterior mesorectal resection (epmr) in combination with rectum-sparing surgery thereby the relevant lymphatic field of the lower rectum can be removed and histologically examined. as a consequence epmr should lower the loco-regional recurrence rate, since the most common causes of such are pre-existent but so far not detectable lymph node metastases besides the incomplete resection of the primary tumor.


Eligibility criteria:
inclusion criteria: * stage t1 (only) * over 18 years old * patient's consent * previous r0 resection of rectal tumor exclusion criteria: * metastases (m1) * neoadjuvant chemotherapy or radiotherapy * meta- or synchronous tumors
preventing youth suicide in primary care: a family model

Conditions: Suicide

Summary: the purpose of the study is to test the efficacy of a brief family therapy (attachment-based family therapy) for youth presenting in primary care with suicidal ideation and depressed mood.

youth suicide is a serious public health problem and clinical challenge for medical and behavioral health providers, yet few preventive interventions have been tested for this population. this project addresses this deficit by testing the efficacy of a brief family therapy for adolescents presenting with serious risk for suicide in a primary care setting. several innovations characterize the study. first, patients will be identified and treated directly in the primary care setting. integrating behavioral health services into primary care may a) reduce burden on physicians by promoting parents as safety monitors, b) increase behavioral health treatment adherence, and c) address many underlying family problems associated with suicide. second, to identify seriously at risk adolescents, we will assess for severe and persistent suicidal ideation and co-occurring depression. patients will need to score above clinical cutoffs on both ideation (siq-jr \> 31) and depression (bdi-ii \>20) at two consecutive appointments (generally within 3 days of each other). third, treatment will target two of the most critical suicide risk factors: depression and family conflict. depression is the most consistently associated risk factor for suicide and family conflict is the most common precipitant of completed suicide (20%) and non-fatal suicidal episodes (50%). fourth, we will use attachment based family therapy (abft; diamond et al., 2002) as the intervention approach, an efficacious and manualized family therapy model specifically designed for adolescent depression. abft has been successful in reducing suicidal ideation, hopelessness, depression, anxiety, and family conflict. participants will be recruited from the primary care centers at the children's hospital of philadelphia. eighty-seven percent of patients are african american and 60% are girls. one hundred adolescents will be randomized to 6 to 10 weeks of either abft or enhanced usual care (euc). patients will be evaluated at baseline 6, 12, 24, and 52 weeks.

Eligibility criteria:
inclusion criteria: * suicidal ideation (siq-jr \> 30) * moderate depressed mood (bdi-ii \> 19) * at least one parent/caregiver willing to participate exclusion criteria: * psychosis * mental retardation or other significant cognitive impairment

Keywords: youth suicide family therapy primary care intervention
penetrating cardiac injuries: outcome of treatment from a level 1 trauma centre in south

Conditions: Penetrating Cardiac Trauma

Summary: retrospective observational study design auditing the outcomes of cardiac injuries in a single centre

retrospective study over a two-year period. the demographics, injury sustained, clinical physiological parameters, mechanism of injury, injury site and patterns, outcomes and in-hospital mortality description of patients who were admitted at a single centre for further management of their cardiac injuries. investigations performed, and procedures that were undertaken were also documented. descriptive statistical analysis was performed. p-value of \<0,05 was considered clinically significant.

Eligibility criteria:
inclusion criteria: all priority one penetrating cardiac injuries seen at cmjah in patients who were 18 years and older - exclusion criteria: dead on arrival -
central sensitisation and postoperative pain

Conditions: Thoracotomy; Hyperalgesia; Hyperalgesia, Secondary; Central Sensitisation; Electroencephalography; Persistent Postsurgical Pain; Humans

Summary: one out of 10 patients undergoing surgery develops persistent post-surgical pain (ppsp). unfortunately, available therapies for treating this pain have limited success. it is therefore of great importance to find strategies to prevent ppsp. the goal of this project is to find new screening tools that identify patients that are at risk for developing ppsp. tissue injury and inflammation following surgery increase the excitability of spinal nociceptive neurons ("central sensitisation", cs) with pain hypersensitivity as consequence. it is thought that cs plays an important role in persistent pain. the first objective of this project is to assess in human patients if the propensity to develop cs manifested as secondary hyperalgesia before surgery is predictive for ppsp. in addition, we will test if the frequency content of the resting-state eeg reflecting the initial state of the brain will be related to the propensity for developing cs and to the presence of ppsp at two months after surgery.


Eligibility criteria:
inclusion criteria: * scheduled for a lateral thoracotomy as treatment for primary lung cancer * ability to provide written informed consent exclusion criteria: * evidence for a clinically-significant alteration of the skin of the volar forearms * pregnancy * having a pacemaker or implanted cardiac defibrillator
a non-randomized study to evaluate leg lymphatic drainage associated with surgical intervention for vulvar cancer

Conditions: Vulvar Cancer

Summary: this will be a non-blinded, non-randomized study to further our knowledge of and experience with lymph node surgery. the investigators are interested in documenting and reporting the variations in leg lymphatic drainage sentinel lymph node biopsy (slnb) with inguinal-femoral lymph node dissection (iflnd). the study will be open at the winthrop p. rockefeller cancer institute at the university of arkansas for medical sciences (uams). dr. pamela stone, dr.alexander burnett, and dr. juan roman will be responsible for accruing subjects to this study. it will be open to all patients presenting to the winthrop p. rockefeller cancer institute with vulvar cancer requiring lymph node evaluation for the ipsilateral and/or contralateral groin who have not had prior groin surgery or radiation to the groins. patients must meet inclusion and exclusion criteria to be enrolled.


Eligibility criteria:
inclusion criteria: * female patients 18-100 years of age. * all races and ethnicities. * being seen in the winthrop p. rockefeller cancer institute for vulvar cancer requiring lymph node evaluation for the ipsilateral or contralateral groin. * willing participation following informed consent process. exclusion criteria: * has not had prior groin surgery or radiation to the groins. * any condition the pi or study physician determines that will put the subject at risk during the procedure. * allergy to blue dye used in lymphatic identification. * pregnant or breast feeding.

Keywords: being seen in the winthrop p. rockefeller cancer institute for vulvar cancer requiring lymph node evaluation for the ipsilateral or contralateral groin
platelet inhibition and bleeding in patients undergoing emergent cardiac surgery

Conditions: Bleeding

Summary: the aim of the study is to evaluate if there is an association between platelet inhibition and surgery-related bleeding in patients undergoing emergent cardiac surgery during dual antiplatelet therapy.

blood for measuring platelet function is drawn before induction of anesthesia

Eligibility criteria:
inclusion criteria: * first time on-pump cabg with or without valve replacement exclusion criteria: * redo surgery, * renal insufficiency needing dialysis, * concomitant medication with warfarin, * preoperative fibrinogen \< 150 mg%

Keywords: emergent cardiac surgery on-pump platelet function
an extension study to provide bortezomib to patients with relapsed or refractory multiple myeloma who previously participated in a bortezomib phase i/ii study and who may benefit from re-treatment with or continuation of bortezomib therapy

Conditions: Multiple Myeloma

Summary: one purpose of this study is to evaluate the effectiveness and safety in long term treatment for patients who completed preceding phase i/ii study. the other purpose is to evaluate the effectiveness and safety of patients who are re-treated with this drug in recommended dose.

multiple myeloma is a kind of malignant disease in the organ which produce blood cells such as bone marrow. it has poor prognosis, especially in patients who are relapsed repeatedly. effective treatment is strongly expected in such relapsed patients in japan. this is a open label multiple center study to evaluate the effectiveness and safety of bortezomib. this study is an extension or re-treatment study for patients who were administered with bortezomib in preceding phase i/ii study. for extension treatment, the same dose of the previous study will be administered into a vein as a bolus twice weekly followed by a 10-day rest (3-week cycle). for re-treatment, a recommended dose determined in phase i/ii study will be administered in 3-week cycle.

Eligibility criteria:
inclusion criteria: * complete 6 cycles treatment in preceding phase i/ii study * response (cr, pr, mr or nc) was obtained in 6 cycles treatment during the preceding phase i/ii study and investigator considers that the patient is expected to have benefit such as antitumor effect, pain relief or improvement of performance state * patients who did not have grade \>=3 non-hematologic toxicity or grade 4 hematologic toxicity during the preceding phase i/ii study or extension treatment of this study * investigator considers that the patient is expected to have benefit of this drug such as antitumor effect, pain relief or improvement of performance state. exclusion criteria: * patient is known to be hbs antigen positive, hcv antibody positive or hiv antibody positive (check is required for patients who received blood product during phase i/ii study) * patients who receive g-csf product or blood transfusion within 7 days before the start of treatment * disease progress was observed during the phase i/ii or this study when patients receive recommended dose * patients who suffer grade \>=2 peripheral neuropathy or grade \>=2 neuropathic pain * patient has new york heart association (nyha) class iii or iv heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, acute ischemia or active conduction system abnormalities.

Keywords: multiple myeloma proteasome inhibitor ubiquitin boronic acids bortezomib
mct8 deficiency caregiver study

Conditions: Monocarboxylate Transporter 8 (MCT8) Deficiency; Allan-Herndon-Dudley Syndrome

Summary: caregivers face many responsibilities outside of their role as a friend or parent, which can lead to emotional, financial, social, and professional challenges. to better understand the impact of mct8 deficiency on caregivers, egetis therapeutics are conducting an online survey for adult caregivers of persons living with the mct8 deficiency.

understanding the impact of mct8 deficiency on caregivers and patients is key to facilitating evidence-based policy interventions and identifying better treatments and treatment practices that take full account of the actual environment in which care is delivered. this study will address the gap in research about the wider impact of mct8 deficiency by exploring the caregiver-reported economic burden and health-related quality of life (hrqol) impact of the disease. adult caregivers will report hrqol outcomes for themselves and the person with mct8 deficiency that they care for, as affected patients have limited cognitive function and communication abilities and cannot report the information themselves. the results from this study will provide insight into the economic and hrqol impact of mct8 deficiency, as reported by caregivers, in the uk, us, canada, france, netherlands, spain, australia, italy, and germany.

Eligibility criteria:
inclusion criteria: * 18 years or older * resident in the uk, us, canada (except newfoundland \& labrador and alberta), france, netherlands, spain, australia, italy, and germany * main caregiver to a person diagnosed with mct8 deficiency exclusion criteria: * paid caregivers to a person diagnosed with mct8 deficiency

Keywords: mct8 deficiency caregiver economic burden hrqol eq-5d-5l pros
correlation between trans esophageal pressure and non-invasive respiratory support failure in patients with acute hypoxic respiratory failure

Conditions: Acute Respiratory Failure

Summary: this study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-pnose) and non-invasive respiratory support failure in patients with acute hypoxic respiratory failure of different etiology (including covid-19).


Eligibility criteria:
inclusion criteria: * age \>18 years * acute hypoxic respiratory failure (p/f \< 200) exclusion criteria: * acute pulmonary edema * chest wall deformities * immediate need for mechanical ventilation * pregnancy * hypercapnic rf

Keywords: non invasive ventilation esophageal pressure transpulmonary pressure
medical record review of hypohidrotic ectodermal dysplasia clinical phenotype

Conditions: Hypohidrotic Ectodermal Dysplasia; X-Linked Hypohidrotic Ectodermal Dysplasia

Summary: this study is being done to collect information about people who have or may have hypohidrotic ectodermal dysplasia (hed) or x-linked hypohidrotic ectodermal dysplasia (xlhed). this study will allow edimer pharmaceuticals to know more about hed/xlhed so that hopefully the investigators can develop a drug to treat this condition. in this study edimer will retrospectively review and abstract (summarize) medical records of people that have or may have hed/xlhed in order to further understand the natural history and disease characteristics.


Eligibility criteria:
inclusion criteria: -males or females with: 1. the clinical characteristics of hed, including at least two of the following characteristics: a history of decreased sweating;abnormal teeth (fewer permanent teeth, teeth are smaller than average and often have conical crowns);sparseness of scalp and body hair. -or- 2. genetically confirmed hed or xlhed;

Keywords: hed xlhed x-linked hypohidrotic ectodermal dysplasia (xlhed)
a prospective multicenter study to evaluate usefulness of cardio-ankle vascular index in japan

Conditions: Stroke; Cardiovascular Death; Nonfatal Myocardial Infarction

Summary: the objective of this five-year prospective observational follow-up study is to examine the additional benefits of using cardio-ankle vascular index (cavi) as a predictive indicator of cardiovascular events in high-risk patients.


Eligibility criteria:
inclusion criteria: patients between 40 and 74 years of age who have either of the following: 1. type 2 diabetes mellitus 2. metabolic syndrome 3. grade i to iii hypertension with the third layer of risk factors according to the guidelines for the management of hypertension japanese society of hypertension(jsh)2009 4. chronic kidney disease(stage g3a or g3b) according ot the clinical practice guidebook for diagnosis and treatment of chronic kidney disease 2012 in japan 5. history of coronary artery disease or noncardiogenic cerebral infarction exclusion criteria: 1. under 40 years of age or over 74 years of age 2. an ankle-brachial index less than 0.9 3. chronic atrial fibrillation 4. current symptoms of heart failure(nyha class iii or iv) or left ventricular dysfunction (ef below 40%) 5. malignancy 6. chronic kidney disease(g4 or g5)according ot the clinical practice guidebook for diagnosis and treatment of chronic kidney disease 2012 in japan 7. chronic dialysis due to renal failure 8. taking steroids/immunosuppressants 9. hepatocirrhosis