Kornimate/medical-research-clean huggingface dataset:
putting cdsmp to work

Conditions: Chronic Disease; Cardiovascular Diseases

Summary: this project is the test of the effectiveness of the chronic disease self-management program which will be translated to a worksite setting.

this project will test adaptations of the chronic disease self-management program (cdsmp) designed to increase the likelihood of widespread use in workplace settings. cdsmp, which has been proven efficacious in community trials, is a six-week program that is designed to help individuals better manage their chronic disease and its many complications. although there is considerable interest among worksite health promotion practitioners for a chronic disease program, cdsmp has not been adapted and tested in workplace settings. in this study, we will determine a) if the cdsmp program tailored to worksites can be efficacious, b) the comparative effectiveness of the worksite tailored cdsmp when compared to the original cdsmp and c) the cost-effectiveness (average and incremental) and return on investment of the two interventions. the participating sites are seven organizations from a rural county in southwest georgia. our partner for the project is the local ymca. ymca staff will be trained to implement the program which will foster sustainability. participants will be randomly assigned to 1) workplace-tailored cdsmp, 2) 'usual care' cdsmp, and 3) control group. data will collected at baseline, 6-month follow-up and 12-months follow-up. the control group will be a delayed intervention group that will be randomly assigned to an intervention group after taking the 6 month survey. the primary outcome measures include blood pressure, cholesterol, blood glucose, bmi, diet, physical activity and tobacco use and the secondary measures including patient-provider communication, quality of life, medical adherence, and work performance and productivity. an average cost-effectiveness analysis will compare interventions to control and an incremental cost-effectiveness analysis will be conducted comparing each intervention to one another. the hypotheses will be tested using a growth modeling approach examining changes over time. this will enable us to maximize the dissemination and implementation of cdsmp across worksite populations by using approaches which are realistic for most work organizations.

Eligibility criteria:
inclusion criteria: * the primary target is all employees 45 years or above with levels of gender and ethnicity similar to those found in the workplaces with which we will work. * if younger individuals wish to participate, we will not turn them away but the program is designed for older adults. it is unlikely we will get a substantial number of participants over 45. exclusion criteria: * none

Keywords: intervention translation workplace cvd cdsmp
cost-effectiveness of home respiratory polygraphy

Conditions: Sleep Apnea Syndrome

Summary: primary objectives: the efficacy of the therapeutic decision taken by respiratory polygraphy (rp) against polysomnography (psg) using the epworth scale; secondary objective: 1. the cost-effectiveness of diagnosis and therapeutic decision valued using the epworth scale and euroqol 5d. 2. effectiveness of the therapeutic decision by means of: 1) quality of life tests, 2) adherence and compliance to treatment, 3) blood pressure map, 4) biochemistry determinations. design: prospective, randomized, controlled, open, parallel of non-inferiority. 440 patients will be randomized to diagnose and follow treatment based on the rp or the psg. the follow-up will last 6 months with 4 assessments. statistical analysis: we will compare the change in the epworth scale between both arms of treatment through analysis of covariance. the premise of non-inferiority is -2 at the lower limit of 95% ic. secondary variables will be analyzed using differences in independent means (or non-parametric equivalent) or chi2 for dichotomous variables. cost-effectiveness: costs generated by one and another method will be evaluated against the effectiveness of the primary variable using bayesian techniques

design: prospective, randomized, controlled, open, parallel noninferiority. 440 patients will be randomized to diagnose and follow treatment based on the pr or psg generating four groups: two treated and two untreated with cpap. the latter did not undergo self-certification home. the monitoring will be 6 months and 4 assessments. statistical analysis: compare the change of the scale epworth before and after the intervention between both treatment arms using analysis of covariance. the premise is non-inferiority of -1.6 at the lower limit of 95%. secondary variables were analyzed by independent means differences (or nonparametric equivalent) or chi2 for dichotomous variables. cost-effectiveness: the costs generated by the two methods will be measured against the effectiveness of the primary endpoint using bayesian techniques

Eligibility criteria:
inclusion criteria: 1. snoring or sleep apneas observed by partner 2. symptoms that may be secondary to the apneas/hypopneas - concretely, an ess ≥10 3. age between 18 and 70 4. absence of clinical suspicion of any other sleep pathology which could cause daytime sleepiness exclusion criteria: 1. psycho-physical inability to complete questionnaires 2. documented structural or coronary cardiopathy not controlled by medical treatment 3. cheyennes-stokes syndrome 4. patient has undergone an uvulopalatopharyngoplasty 5. unable to provide informed consent

Keywords: sleep apnea, portable monitor,autocpap
4-week mindfulness program for adults with chronic pain

Conditions: Chronic Pain

Summary: the objective of this study is to determine the feasibility and acceptability of a 4-week mindfulness training program for adults with chronic pain (noncancer related). the intervention is based on the mindfulness-based stress reduction program, an 8-week mindfulness training program developed to help people manage stress-related and chronic conditions. the adapted mindfulness intervention will consist of four, weekly 1 hour and 30 minute group sessions that are modified from the original program to fit the shorter length and to directly address chronic pain management. participants will complete pre- and post-intervention surveys and daily mindfulness practice diaries, all online. the surveys will help us determine if participants experience decreased pain interference, increased quality-of-life, and increased psychological well-being over the course of the intervention. participants will also complete a post-intervention telephone interview to help determine satisfaction with the intervention and areas where the intervention can be improved.


Eligibility criteria:
inclusion criteria: * one or more chronic noncancer pain diagnoses (daily pain for at least 3 months) * has a pain management provider * reports more than minimal pain bothersomeness and interference in general activities * able to read and understand english exclusion criteria: * diagnosis of mental illness with psychotic features * history of inpatient admission for psychiatric disorder in past 2 years * active alcohol or substance abuse within the past year * has completed a mindfulness-based stress reduction or other mindfulness course; has or previously had a regular mindfulness meditation practice. * unable or unwilling to comply with study procedures (online questionnaires and practice diaries, 4 weekly intervention sessions, home practice, and one semi-structured phone interview).

Keywords: mindfulness-based stress reduction mindfulness chronic pain feasibility intervention
testicular growth during puberty in boys with and without a left-sided varicocele

Conditions: Varicocele; Scrotal Disorder

Summary: prospective observational study. a varicocele is defined as a dilatation of the veins in the plexus pampiniformis in the testicles. varicoceles are a diagnostic dilemma and a therapeutic challenge. most of the boys with a varicocele don't show any symptoms, but approximately 15-20% experience some sort of infertility later during their life. there still isn't any consensus on when treating the patient is the right choice. reliable scientific research about parameters able to predict the later stages of the boy with a varicocele is therefore needed. the purpose of this study is to how testicular growth could predict the outcome of boys with a varicocele. during this study, testicular growth in boys with and without a left-sided varicocele will be examined in different schools using ultrasound to measure the testicular volumes, the prf and the tai to be able to collect sufficient data with the purpose to be able to predict whether testicular growth is a significant predictor on the progression of a varicocele.


Eligibility criteria:
inclusion criteria: 1. boys aged 11-16 years without any evidence of a current or past pathology influencing testicular growth exclusion criteria: 1. boys with a current or past inguinoscrotal pathology (varicocele, testicular microlithiasis, cryptorchidism, retractile testis, orchidectomy, testicular torsion, orchitis or epididymitis, hypospadias, inguinal hernia, oeprated varicocele, hydrocele and epididymal cysts) 2. boys with evidence of disorders influencing testicular growth (e.g. growth disorders) 3. boys with missing or incomplete data on tanner stages for genital development 4. boys with a psychiatric disorder

Keywords: varicocele testicular growth
the effects of passive vibration in patients with diabetic peripheral neuropathy

Conditions: Diabetic Neuropathies

Summary: the purpose of this study is to examine the effects of passive vibration (pv) in improving balance and sensation in patients with diabetic peripheral neuropathy (dpn).

the study involves the following: * visit 1: * particpant's age, height, gender, and weight will be collected. * participant will fill out a questionnaire to assess participant's nerve function. this process will take approximately 2.5 minutes. * investigator will measure participant's balance, sensation, and skin blood flow (sbf). * after completing the tests, participant will be randomly assigned by the computer to either the treatment group or control group. * the treatment group will receive a passive vibration treatment for 15 minutes twice a week for 4 weeks. * the control group will not receive any treatment and they will continue their usual lifestyle. * visit 2 through 8: * the treatment group will receive a passive vibration for 15 minutes followed by sbf measurement. * the control group will continue their usual lifestyle. * in the fifth session, the treatment and control groups will come back for tests. * visit 9 (follow-up):

Eligibility criteria:
inclusion criteria: * a diagnosis of diabetic peripheral neuropathy * minimum age 40 years * maximum age 75 years * ability to stand for a minimum of five minutes exclusion criteria: * neurological disorders * bleeding disorders * leg ulcers * cardiovascular diseases * complete absence of sensation in lower extremities (i.e. 6.65 in monofilament test) * self-reported pregnancy
high-flow nasal cannula nebulization of beta 2 adrenergic agonist during acute exacerbation of chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease; High-flow Nasal Cannula

Summary: high-flow nasal cannula is an oxygenation technique increasingly used for patients admitted for acute respiratory failure. literature essentially concerns "de novo" acute hypoxemic failure and the interest of high-flow during take care of chronic obstructive pulmonary disease patients is few studied. physiological studies reported potential benefits of high-flow nasal cannula oxygenation in chronic obstructive pulmonary disease patients including dead space clearance and decrease of respiratory, which lead to decrease work of breathing. as inhaled bronchodilators are part of treatment of chronic obstructive pulmonary disease exacerbation, nebulization could be also provided through high-flow nasal cannula oxygen therapy. the aim of our study is to determine whether a beta-2 agonist nebulization administered through high-flow nasal cannula is efficient to improve spirometry of patients for admitted hronic obstructive pulmonary disease exacerbation.


Eligibility criteria:
inclusion criteria: * arterial ph over 7.25, * respiratory rate under 35 breaths/mn * glasgow coma scale equal to 15, * indication of beta-2 agonist nebulization less than 8 per day (time between two nebulization more than 3 hours), * niv sessions spaced more than 6 hours. exclusion criteria: * urgent endotracheal intubation; * contraindication to beta 2 adrenergic agonist; * another organ failure (hemodynamic and neurological instability); * cardioselective beta-blocker during treatment of copd exacerbation;
management of fournier gangrene at ibn rochd university hospital center

Conditions: Fournier Gangrene

Summary: case series with retrospective data collection of patients treated for fournier's gangrene between january 2010 and march 2017. the main etiologies, risk factors, postoperative complications outcomes and long term follow up results were analyzed.

eight four (84) patients were recruited. the average age of our patients was 49 years (with limits of 20 to 76), the male gender dominates our series (83.33%) with a sex ratio of 5m / 1w, the most frequently found risk factor was diabetes mellitus (37%). the most common etiology was anal abscesses (32%). the average time to consultation was 8 days (limits ranges from 3 to 30 days). all patients were admitted at a necrosis stage (100%). anemia was identified in 85% of cases. the low platelets were noticed in 44.03% of cases. hypoalbuminemia was found in 93% of cases. all patients (100%) benefited resuscitation initially and antibiotic therapy on their admission. they received emergency surgical debridement with a cleansing stoma. the average length of hospital stay was 13 days and complications occurred in 33% of cases. the mortality rate was 7.14%. then we conclude that fournier's gangrene is a medico-surgical emergency with a high morbidity and mortality rate. early diagnosis as well as antibiotic therapy and the quality of debridement save the patients.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of fournier gangrene exclusion criteria: * other perineal diseases which are differential diagnosis of fournier gangrene

Keywords: fournier's gangrene, stoma, necrosectomy
how cricket powder affects gut microbiome and cholesterol metabolism

Conditions: Hypercholesterolemia

Summary: cardiovascular disease (cvd) is the leading cause of death worldwide, including in thailand. one of the major risk factors for cvd is dyslipidemia, or abnormal levels of cholesterol and other fats in the blood. recent research suggests that the balance of gut microbiota, the community of microorganisms living in the digestive system, may play a key role in regulating cholesterol levels and overall metabolism. this study explored the potential health benefits of cricket powder, a high-protein food that is already safely consumed in many parts of the world. previous studies have shown that cricket powder may increase the number of beneficial gut bacteria, especially bifidobacterium animalis, which supports the production of short-chain fatty acids (scfas) known to improve fat metabolism. although crickets are considered safe to eat, more research is needed to understand their effects on gut health and blood cholesterol, especially in people with high cholesterol levels. this study assessed the safety of cricket powder consumption and whether it can help improve gut microbiota balance and lower cholesterol in thai adults.


Eligibility criteria:
inclusion criteria: * healthy, aged in the 20 - 60 range * bmi (body mass index) in the range of 18.5 - 29.9 kg/m2 * no underlying diseases * no gastrointestinal surgery * the fasting blood parameters of total cholesterol and ldl-c are higher than 200 mg/dl and 130 - 189 mg/dl, respectively. * the fasting blood triglyceride must be less than 500 mg/dl. * the fasting blood glucose must be less than 110 mg/dl. * alt (alanine aminotransferase) and ast (aspartate aminotransferase) must be less than 60 units/l. * egfr (estimated glomerular filtration rate) must be at least 90 ml/min/1.73 m2. * blood pressure must be less than 160/90 mmhg. * heart rate must be less than 100 times/minute. * no smoking * be able to consume pork congee exclusion criteria: * allergic to insects, chitin, chitosan, shrimp, dust mites, and other crustacean products * pregnant or breastfeeding * participating in other research projects, and receiving drugs, herbs, and supplements * receiving steroid, antibiotic, or other drugs that may affect lipid metabolism * consuming alcohol more than 2 drinks per day e.g., beer of 24 ounces, wine of 10 ounces, and distilled spirits of 3 ounces * regularly consuming probiotic products and cannot stop consuming them * having histories of diabetes, chronic liver diseases, chronic kidney diseases, cardiovascular diseases, cancer, anemia, irritable bowel syndrome, ulcerative colitis, or anaphylaxis

Keywords: gut microbiome hypercholesterolemia cricket insect
characterization of skin microbiome profile and it's correlation to radiation dermatitis

Conditions: Radiation Dermatitis

Summary: the purpose of this study is to characterize the skin microbiome profile of breast cancer patients before and after receiving radio therapy treatments, and evaluate the relationship between the microbiome profile and radiation dermatitis severity (grade) that the patient will develop. such characterizations can lead to potential biomarkers and/or therapeutic targets that can be used for the prognosis, prevention and treatment of this condition.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. histological confirmation of breast malignancy 3. primary or recurrent disease eligible 4. patients after breast lumpectomy and that scheduled to receive radiotherapy 5. patients that receive minimum of 45 gy 6. ability to complete questionnaire(s) by themselves or with assistance 7. provide informed written consent exclusion criteria: 1. patients with prior radiotherapy to any portion of the planned treatment site 2. tumour involvement of the skin 3. patients with active rash, pre-existing dermatitis, lupus, or scleroderma 4. patient with other skin diseases/ skin disorders 5. recent use of systemic or topical antibiotics or antifungal medications within 21 days of first swab collection. 6. recent use of any of the following within 21 days of first swab collection: o systemic or topical steroids o use of systemic immunosuppressant drugs o use of ultraviolet light therapy 7. prior usage of other topical and systemic medications within 21 days of first swab collection 8. prior usage of topical cosmetic products, creams, lotions, or gels within 14 days of first swab collection in areas where samples are taken. 9. clinical evidence of infection that in the judgement of the principle investigator would interfere with proper assessment of the skin microbiome 10. prior organ or bone marrow transplant 11. any other reason that, in the opinion of the investigator, prevents the subject from participating in the study or compromise the patient safety

Keywords: radiation dermatitis radio therapy microbiome profile
natrova photoallergy study - natrova creme rinse in healthy volunteers

Conditions: Head Lice

Summary: photoallergic reactions are assumed to be due to a delayed cell-mediated hypersensitivity response that requires the presence of ultraviolet irradiation. the predictive procedure is, therefore, based on modification of the repeated insult patch test (kaidbey, 1991). duplicate sets of patches of test articles are used with exposure of only one set to uv radiation and subsequent evaluation of both sets for skin reactions in order to compare irradiated versus non-irradiated test sites.

the study consists of of following phases: screening, induction, rest, challenge, and re-challenge (if necessary). the study will be conducted as a randomized, evaluator-blind test design.

Eligibility criteria:
inclusion criteria: * male or female subjects 18-65 years of age * has the ability to understand and has signed a written informed consent form and hipaa authorization * females of childbearing potential must agree to use an adequate birth control * fitzpatrick (1988) skin type i, ii, or iii. exclusion criteria: * history of severe reactions from exposure to sunlight * known allergies or sensitivities to adhesives in patches, medical tape, or ingredients found in the test articles * inability to evaluate the skin in and around the test sites * diabetes requiring medication * clinical significant skin diseases which may contraindicate participation * asthma or any other severe respiratory disease requiring chronic medication * known immunological disorders such as hiv, aids, sle and/or ra * history, within the last six months, of current cancer, including skin cancer * mastectomy for cancer removal of lymph nodes draining test sites * epilepsy * pregnancy, lactation, or planning a pregnancy during the test period * chronic use of systemic antihistamine medication, or use within 14 days prior to screening visit * use of anti-inflammatory drugs (exception: acetaminophen and \< 81 mg.day aspirin are permitted) within 2 days of screening visit * currently receiving allergy injections * currently taking or expecting to take any photosensitizing medications * use of immunosuppressive drugs * topical drugs used at the test sites within the last 7 days prior to screening * current participation in any clinical trial * participation in any patch test for irritation or sensitization or any test involving uv exposures within 4 wees of study start * use of any investigational therapy within the past 4 weeks.

Keywords: head lice natrova creme rinse - 1% is intended for the treatment of head lice
hypothalamic-pituitary-adrenal (hpa)-axis study in pediatric subjects with perennial allergic rhinitis (par)

Conditions: Allergic Rhinitis

Summary: the purpose of this study is to compare the effect of 6 weeks of treatment with beclomethasone dipropionate (bdp) nasal aerosol versus placebo on hpa-axis function, as assessed by 24-hour serum cortisol weighted mean, and to evaluate the safety and tolerability of bdp nasal aerosol, in subjects 6 to 11 years of age with perennial allergic rhinitis.


Eligibility criteria:
inclusion criteria: * informed consent/(assent - if applicable) * male or female subjects 6-11 years of age * general good health * a documented history of par to a relevant perennial allergen for a minimum of 12 months * other criteria apply exclusion criteria: * pregnancy, nursing, or plans to become pregnant or donate gametes * participation in any investigational drug study within the 30 days preceding the screening visit 1 (sv1) * previous participation in a bdp nasal aerosol study as a randomized subject * a known hypersensitivity to any corticosteroid or any of the excipients in the study medication formulation * history of physical findings of nasal pathology, including nasal polyps or other clinically significant respiratory tract malformations * history of a respiratory infection or disorder within the 14 days preceding the screening visit 1 (sv1) * use of any prohibited concomitant medications within the prescribed (per protocol) withdrawal periods prior to the screening visit 1 (sv1) * other criteria apply * current smoker or current user of tobacco products at any time during the study; history of smoking or use of tobacco products within the past year

Keywords: pediatric subjects