Kornimate/medical-research-clean huggingface dataset:
an exploratory study of hrd score in chinese ovarian cancer patients benefiting from parp inhibitor targeted therapy

Conditions: Ovarian Cancer

Summary: this project intends to evaluate the sensitivity of different homologous recombination deficiency (hrd) score to poly(adp-ribose) polymerase inhibitor (parpi) by retrospectively analyzing the tissue samples of patients with ovarian cancer using parpi, and to determine the cut off value of the hrd score algorithm suitable for the chinese population, so as to provide evidence for the role of parpi in ovarian cancer. the screening of the beneficiaries of maintenance therapy provides precise guidance and can be used as a reference for other cancer types.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years; 2. high-grade serous/endometrioid epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer; 3. figo stage iii or iv; 4. at least 6 cycles and no more than 9 cycles first-line platinum-containing chemotherapy; 5. cr or pr after chemotherapy; 6. ecog 0-1; 7. sufficient biological samples for hrd score detection; 8. patients signed informed consent; 9. good bone marrow function. exclusion criteria: 1. incomplete follow-up records of survival information; 2. unqualified biological sample quality control

Keywords: homologous recombination deficiency score
oncological surgery in times of covid-19: effectiveness of preoperative screening for sars-cov-2

Conditions: SARS-CoV-2; Oncology; Surgery

Summary: to evaluate the incidence of patients with a positive test for sars-cov-2, performed in the preoperative screening for patients treated at the institution

cohort, prospective, observational study to evaluate the incidence of asymptomatic patients with a positive sars-cov-2 test detected in the preoperative screening program of the institution.

Eligibility criteria:
inclusion criteria: * patients with elective surgery scheduled at the ibcc, including those diagnosed with any type of cancer; * patients who will undergo the screening test for sars-cov-2 by rt-pcr (nasal swab), according to the guidelines and protocol of the hospital exclusion criteria: * urgent or emergency surgery; * screening test for sars-cov-2 not performed * incomplete data in the institutional database

Keywords: sars-cov-2 surgical oncology pt-pcr screening test
effect of drainage of subglottic secretions on pneumonia acquired under mechanical ventilation

Conditions: ICU's Patients Under Mechanical Ventilation

Summary: the purpose of this study is to determine whether drainage of subglottic secretions is effective to reduce the incidence of pneumonia acquired under mechanical ventilation in icu's patients.

nosocomial infection represent a major problem in hospitals. in intensive care units, ventilator-associated pneumonia (vap) is associated with an increase in morbidity and mortality. incidence of vap is high, 20 to 30% of patients under mechanical ventilation (mv) for more than 48 hours. in the pathogenesis of vap, two processes are considered essential for its development: bacterial colonization of the oropharynx and tracheobronchial tract, followed by aspiration of contaminated secretions into the lower airways. it has been shown that pooled secretions above inflated endotracheal tube cuffs may be source of aspiration and can be a cause of vap. several studies have suggested that recurrent aspiration of subglottic secretions can be prevented by intermittent drainage of subglottic secretions. nevertheless, recent cdc guideline reported that there was not enough evidence to conclude on the efficacy of such intervention. during the study, patients, in both groups, will be intubated with the same device permitting subglottic drainage (hilo evac endotracheal tube). the daily screening of vap will be performed until the 28th days of mechanical ventilation without occurrence of vap. the follow-up of each patient will be realized until the icu's discharge. comparison: the incidence of vap will be compared between two groups: one group with intermittent drainage of subglottic secretions and the other one without this intervention.

Eligibility criteria:
inclusion criteria: * icu patients expected to require mv more than 48 hours exclusion criteria: * patients already intubated for more than 12 hours * patients intubated with another tube than the hilo evac tube * patients admitted for cardiac arrest * patients admitted for self poisoning * patients admitted with tracheotomy * patients already included in an another clinical trial

Keywords: randomised control trial intensive care unit mechanical ventilation ventilator-associated pneumonia drainage of subglottic secretions
verification of a pharmacogenetic approach to customizing chemotherapy to asians

Conditions: Colorectal Cancer

Summary: interethnic variability in chemotherapy response is becoming increasingly evident, making approaches for customizing chemotherapy treatment to different ethnic populations desirable. at the same time, significant genetic variation has also been observed between ethnic groups, including many germline and somatic pharmacogenetic variants involved in chemotherapy pharmacology. recently, based on meta-analyses of studies on germline pharmacogenetic variant frequencies and clinical trials, the investigators found that chemotherapy outcomes between asians and caucasians colorectal cancer (crc) patients could potentially be inferred from the frequencies of variants between the ethnic groups and their respective biological functions. in this study, the investigators seek to further clarify the validity of using pharmacogenetic variants to customize chemotherapy between ethnicities through the following specific aims: (1) to verify the differences observed in the frequency of germline pharmacogenetic variants related to chemotherapy between asian and caucasian crc patients, (2) to test whether variations in the frequency of somatic pharmacogenetic gene mutations between asian and caucasian crc patients could be used to infer differences in clinical outcomes between the two ethnicities. (3) (4) for aim 1, dna samples from approximately 1000 asian and caucasian crc patients each will be analyzed for the frequency of a panel of germline pharmacogenetic variants identified in our meta-analyses using high-throughput methodology. for aim 2, meta-analyses will be performed on pharmacogenetic studies and clinical trials to establish the relative frequencies of somatic variants and clinical outcomes in asian and caucasian crc patients. these frequencies will be verified on the same series of dna samples used in aim 1. the clinical outcomes inferred from the frequency differences and biological functions will then be compared to those summarized from clinical trials. this data could provide a basis for developing a rational approach to customizing chemotherapy in non-caucasian populations and improve assessment of drug feasibility in different ethnic populations.if validated, this working hypothesis would be of high clinical interest, giving the opportunity to use this as a dna prognosis biomarker in crc. pharmacogenetic frequencies could be a potentially useful approach for predicting likely chemotherapy outcomes in non-caucasian populations


Eligibility criteria:
inclusion criteria: * patients with colorectal cancer
dermacyd femina (lactic acid) pocket br - compatibility

Conditions: Hygiene

Summary: to demonstrate the absence of irritation potential (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product dermacyd femina (lactic acid) pocket br.


Eligibility criteria:
inclusion criteria: * age between 18 and 60 years old; * phototype skin i,ii, iii e iv * integral skin test in the region; * willingness in following the study procedures and to be present in the clinic at the days and scheduled time for medical evaluations and for application of occlusion; exclusion criteria: * lactation or gestation * use of antiinflammatory and/or immunosuppression drugs one month before the study; * personnel history of atopy; * history of sensitivity or irritation for topic products; * active cutaneous disease; * use of new drugs or cosmetics during the study; the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
the erlangen fitness and prevention study (efops).

Conditions: Osteoporosis; Osteopenia; Early Postmenopause

Summary: the study determines the long-term effect of exercise on osteoporotic fracture risk. since actually no controlled supervised exercise study exceeds the time frame of 4 years, knowledge concerning the long-term effect of exercise on fractures and fracture-risk factors is scarce. within the erlanger fitness and osteoporosis study (efops, an ongoing controlled exercise study with currently 16 years of supervised exercise with 45-50 osteopenic, early-postmenopausal women in exercise and sedentary control group each, the investigators therefore focus on overall-fractures, bone mineral density and falls.


Eligibility criteria:
inclusion criteria: * participants of the efops-study, * 12 years of exercise training according to the efops-protocol (exercise). exclusion criteria: * medication and diseases affecting bone metabolism, * inflammable diseases, * cardiovascular diseases, * start of relevant physical exercise programs beside the efops protocol.

Keywords: osteoporosis exercise fractures bone mineral density chd-risk
better classification of respiratory amyloidosis

Conditions: Amyloidosis

Summary: the b-ar project is based on a retrospective analysis of amyloidosis typing and the identification of their amylogenic protein.this work should be able to unite many clinicians, including pulmonologists and pathologists around a rare disease that still suffers from insufficient data.

the b-ar study will highlight the interest of proteomic analysis of amyloidosis compared to their identification by immunostaining. the objective is to reduce diagnostic wandering and to improve patient management. the typing of respiratory amyloidosis will allow a better characterization of the disease and thus, to propose a dedicated therapeutic management.

Eligibility criteria:
inclusion criteria: * adult patient \> to 18 years with amyloidosis on a histological sample of the tracheobronchial or pulmonary tree. exclusion criteria: * subject receiving state medical aid * subject deprived of freedom, or under a legal protective measure (example: patients under guardianship or curators)

Keywords: respiratory amyloidosis proteomic analysis
evaluation with ct scan of possible changes in airways after treatment with daxas® in severe chronic obstructive pulmonary disease patients

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: in this study the possible changes in airway geometry and function induced by 6 month oral treatment with daxas® (roflumilast) will be evaluated. the use of functional respiratory imaging (fri) on the phenotyping of chronic obstructive pulmonary disease (copd) patients will be examined. the study population consists of 40 severe copd patients, global initiative for chronic obstructive lung disease (gold) stages iii until iv. imaging parameters will be assessed and the correlation with lung function and health related quality of life will be checked before and after treatment.


Eligibility criteria:
inclusion criteria: * male or female patient ≥ 30 years old * patient with bmi ≥ 20 * written informed consent obtained * female patient of childbearing potential who confirm that a contraception method was used at least 14 days before visit 1 and will continue to use a contraception method during the study. * patient should be treated according to gold guidelines * copd patient with gold stages iii until iv * patient with smoking history of at least 10 pack-years * patient takes spiriva® and a fixed combination of inhaled steroids and long acting beta agonist (laba) at least 6 weeks before visit 1 * patient must be able to understand and complete the protocol requirements, instructions, questionnaires and protocol-stated restrictions. exclusion criteria: * pregnant or lactating females * patient with severe immunological diseases and/ or severe acute infectious diseases. * patient with heart failure * patient with diagnosis of cancer (except basal cell carcinoma) * patient with a history of depression associated with suicidal ideation or behaviour * patient with moderate or severe hepatic impairment. * patient with lactose intolerance * patient is unlikely to comply with the protocol or unable to understand the nature, scope and possible consequences of the study. * patient who received any investigational new drug within the last 4 weeks prior to the screening visit or twice the duration of the biological effect of any drug (whichever is longer).

Keywords: pulmonary disease, chronic obstructive computed tomography scan functional respiratory imaging roflumilast health related quality of life
the psychological impact of the covid-19 on students.

Conditions: Mental Health Wellness 1

Summary: the covid-19 outbreak has been rapidly transmitted in late january 2020 and aroused enormous attention globally. the public at large may also experience boredom, disappointment, and irritability under the isolation measures. depression and anxiety are common mental health problems experienced by university students. this survey aims to investigate the psychological impact of covid 19 on students.

the covid-19 outbreak has been rapidly transmitted in late january 2020 and aroused enormous attention globally. infected patients may develop severe and even fatal respiratory diseases (e.g., acute respiratory distress syndrome (ards) and acute respiratory failure) ending up in intensive care. apart from physical suffering, it is not uncommon for confirmed or suspected cases of covid-19 to suffer from great psychological pressure and other health-related problems. the limited knowledge of the covid-19 and the overwhelming news may lead to anxiety and fear in the public. the public at large may also experience boredom, disappointment, and irritability under the isolation measures. depression and anxiety are common mental health problems experienced by university students. being in higher education is associated with many stressors and transitional events, and students fall within the age range when common mental health problems are at their developmental peak. depression and anxiety can impair students' academic performance and social functioning, cause significant burden at university, and potentially affect their future career opportunities. the study includes 2 parts. part a is an online survey study with non-probabilistic convenience sampling and part b is focus group interviews. this study aims to explore the psychological impact of covid-19 and coping methods in higher education students.

Eligibility criteria:
inclusion criteria: • higher education students aged 18 years and above exclusion criteria: • subjects refuse to answer this questionnaire

Keywords: stress depression higher education students psychological impact
relationship between aspirin metabolism and markers of metabolic dysfunction among pregnant persons at risk of pre-eclampsia

Conditions: Preeclampsia; Preeclampsia (PE); Preeclampsia (PE) Risk; Obesity and Obesity-related Medical Conditions; Pregnancy; Pregnancy Complications; Gestational Diabetes; Gestational Diabetes Mellitus in Pregnancy; Gestational Complications

Summary: this study's primary purpose is to determine the relationship between aspirin metabolism and markers of metabolic dysfunction among patients at risk for preeclampsia. further, we will add an exploratory outcome to evaluate the neonatal body composition and anthropometric data to better understand neonatal impacts of maternal metabolic dysfunction.


Eligibility criteria:
inclusion criteria: * recommended aspirin for pre-eclampsia prevention by ob/gyn or mfm specialist based on acog and uspstf guidelines (1 high risk factor, 2+ moderate risk factors) * willingness to adhere to aspirin therapy * willingness to undergo 2h ogtt for serum and urine collection in addition to survey collection, indirect calorimetry, body composition measures, neonatal measures, etc. * gestational age at enrollment \<16 weeks * ability to speak, read, and communicate via english exclusion criteria: * type 2 diabetes mellitus * type 1 diabetes mellitus * current gestational diabetes mellitus * current/active platelet disorder or bleeding diathesis (thrombocytopenia of any etiology, idiopathic thrombocytopenic purpura/itp, thrombotic thrombocytopenic purpura/ttp, von willebrand disease, etc.) * thrombophilia * current use of nsaid for other indication (indomethacin, ibuprofen, etc.) * current use of other immune-modulating agents and biologics (hydroxychloroquine, azathioprine, 6-mercaptopurine, il-6 inhibitors, etc.) * current or recent use of steroids * current use of prophylactic or therapeutic anticoagulation * medical contraindication to aspirin therapy * molar pregnancy * renal disease * inability or unwillingness to give informed consent * current psychiatric illness/social situation that would limit compliance with study requirements, as determined by the principal investigators

Keywords: metabolic dysfunction gestational diabetes pregnancy maternal obesity maternal insulin resistance aspirin metabolism gdm substrate oxidation gestational glucose intolerance
travatan versus timoptic in treating open-angle glaucoma or ocular hypertension

Conditions: Glaucoma

Summary: to evaluate the intraocular pressure (iop) lowering efficacy and safety of travoprost 0.004% compared to timolol 0.5% in patients with open-angle glaucoma (oag) or ocular hypertension (oh). the study structure is a parallel design. the patients will receive treatment for 12 weeks.

to evaluate the iop lowering efficacy and safety fo travoprost 0.004% compared to timolol 0.5% in patients with open-angle glaucoma (oag) or ocular hypertension (oh). the study structure is a parallel design. the patients will receive treatment for 12 weeks.

Eligibility criteria:
inclusion criteria: * ≥18 years; * iop=16-30mmhg * oh or oag with visual filed abnormality: 1. ≥3 adjacent points in 24 degrees field on the same side of the horizontal meridian, that have p \<5% on the prepapillary diameter plot, one of which must have p \<1%, 2. glaucoma hemifield test outside normal limits, 3. corrected pattern standard deviation with p \<5% exclusion criteria: * previous damage of anterior chamber angle; * ocular inflammation or ocular surgery within the past 3 months; best corrected visual acuity (logmar) \<1.0; * contact lens wearer; * severe central field loss; * uncontrolled cardiovascular, hepatic or renal disease; * any medication within past 1 month.

Keywords: glaucoma
alzheimer's pet imaging in racially/ethnically diverse adults

Conditions: Alzheimer Disease

Summary: the study employs tau positron emission tomography (pet) imaging in a well-characterized multi-racial/ethnic cohort to examine the extent to which tau pathology is associated with cognition, differences in tau pathology across racial/ethnic groups, and the relationship between mri markers of small-vessel cerebrovascular disease and tau pathology. the study also investigates amyloid-dependent tau spreading.

deposition of hyperphosphorylated tau protein is observed in several neurodegenerative diseases including alzheimer's disease (ad), progressive supranuclear palsy, corticobasal degeneration, chronic traumatic encephalopathy, and frontotemporal lobar degeneration. tau is a microtubular protein and its native function is to provide structural support to neurons. paired helical filaments composed of dysfunctional tau protein are found in several neurodegenerative diseases. in ad, the clinical progression of dementia has been shown to correlate with the amount and topographical spread of tau throughout the brain. therefore, detecting and quantifying tau aggregate load in brain would have diagnostic and prognostic potential in clinical management of several neurological diseases. as disease modifying drugs that target tau are being developed, there is a critical need for a reliable method of detecting tau aggregates to confirm pathology in patients entering clinical trials.

Eligibility criteria:
inclusion criteria: * aged 35 - 85 years * have either mild cognitive impairment or mild clinical alzheimer's disease; or have no problem with memory or thinking. * able to participate in all scheduled evaluations and to complete all required tests and procedures * considered likely to comply with the study protocol and to have a high probability of completing the study exclusion criteria: * past or present history of a certain brain disease other than mild cognitive impairment or mild clinical alzheimer's disease. * certain significant medical conditions. examples are uncontrolled epilepsy or multiple serious injuries. * unable to lie still for pet scans. * radiation exposure for research studies in the last year that would put you past allowable limits if included in this study. * participation in the last year in a clinical trial for a disease modifying drug for ad unless it can be determined that your received placebo and not active drug. * conditions that preclude entry into the scanner (e.g. claustrophobia, etc.). * inability to have a catheter in your vein for the injection of the radioligand (dye). * currently pregnant or breastfeeding.

Keywords: tau amyloid mk-6240 florbetaben racial/ethnic minority alzheimer's disease
computational modelling of myocardial perfusion to improve outcome prediction based on coronary artery stenosis and atherosclerotic plaque burden assessment by computed tomography

Conditions: Chronic Coronary Syndrome

Summary: detection of coronary stenosis is of utmost importance in identifying vulnerable patients. the combined use of coronary computed tomography angiography at rest (ccta) and stress myocardial computed tomography perfusion (stress-ctp) provides both anatomic and functional analysis of coronary artery disease (cad) using a single imaging test. stress-ctp evaluates myocardial perfusion by measuring myocardial blood flow (mbf) under pharmacologically induced stress conditions. the drawback is that stress-ctp requires additional scanning and administration of an intravenous stressor with an increase in radiation exposure and potential stressor-related side effects. the investigators recently patented a computational model that can reproduce mbf under stress conditions (italian patent n. 102021000031475 metodo implementato mediante computer per la simulazione del flusso sanguigno miocardico in condizioni di stress \[computational method for simulating myocardial blood flow in stress conditions\], half owned by centro cardiologico monzino, half by politecnico di milano). on top of this, ccta can characterize plaque type and identify adverse plaque characteristics. moreover, biomechanics analysis allows the study of luminal stenosis and stress within the plaque. finally, radiomics, extracting quantitative features from medical images to create big data and identify novel imaging biomarkers, can be applied to improve the diagnostic accuracy of coronary plaques.


Eligibility criteria:
inclusion criteria: * symptomatic patients with suspected cad referred for nonemergent, clinically indicated non-invasive coronary angiography. exclusion criteria: * low pre-test likelihood of cad * prior myocardial infarction * previous history of revascularization * acute coronary syndrome * need for an emergent procedure * evidence of clinical instability * contraindication for contrast agent or impaired renal function * inability to sustain a breath-hold * pregnancy * atrial fibrillation or flutter * bmi \> 35kg/m2 * presence of pm or icd * contraindications to the administration of sublingual nitrates, betablockade, and adenosine

Keywords: ct perfusion myocardial blood flow