Kornimate/medical-research-clean huggingface dataset:
monitoring movement for pressure ulcer prevention

Conditions: Pressure Ulcer

Summary: the goal of this work is to develop and test an automated movement detection monitoring tool that could lead to reduced burden on clinicians and in-turn reduce pressure ulcer incidence rates. ten healthy participants will perform video-recorded bed movements while weight distribution and interface pressures at bony prominences on the pelvis are recorded.

the incidence rate and subsequent costs of preventable pressure ulcers is astounding. although pressure ulcer risk assessment tools and prevention approaches have been a topic of research and for many years, the incidence rate has remained relatively consistent. one reason that progress has not been made to lower the incidence rate is that there is no objective monitoring tool to determine how much a person is moving or is being moved in their bed. current practices are time-intensive and have not yet leveraged intelligent monitoring technology that could reduce clinical burden and increase accuracy of the risk assessment and efficacy of prevention protocols. the goal of this work is to develop and test an automated movement detection monitoring tool that could lead to reduced burden on clinicians and in-turn reduce pressure ulcer incidence rates. this monitoring tool will be an extension of our intelligent bed sensor we developed named the embedded scale, or e-scale. the e-scale currently has software modules that detect bed exit, individual weight, and multi-person weight. the project described here would develop a movement module for the e- scale to monitor people's movements in bed in an attempt to eventually reduce incidence of pressure ulcers in clinical care.

Eligibility criteria:
inclusion criteria: * age 18 and older exclusion criteria: * not able to independently get onto a bed and reposition themselves * skin lesions in the area where sensors will be placed
supplementary oxygen in surgical and medical wards evaluated by 30-day mortality

Conditions: Oxygen Toxicity; Oxygen Deficiency

Summary: this study evaluates the use and effects of supplementary oxygen in surgical and medical wards on patients admitted to a hospital in the capital region of denmark. the population will be divided in to three groups according to their oxygenation status. the main outcome will be 30-day mortality, with secondary outcomes being length of stay, 30-day admission to icu, 30-day reoperations, 30-day readmission, and peak values within 30-days of c-reactive protein, s-creatinine, troponin.


Eligibility criteria:
inclusion criteria: * admission date between 1st of january 2014 to 29th of december 2014 on a hospital in the capital region of denmark * age ≥18 * unique (first) admission in database for either: * hip fracture requiring surgery * chronic obstructive pulmonary disease in exacerbation * acute mycardial infarction * open abdominal surgery exclusion criteria: * no data on saturation within 48 hours after * admission (medical patients) * discharge from the post anaesthesia care unit (surgical patients) * no data on primary outcome (30-day mortality)
active monitoring and determinants of incidence infection of covdi-19

Conditions: Coronavirus Infection

Summary: 7. objectives to apply e-health methods to perform active monitoring and assess determinants of incident infection of covid-19 in a hospital population. 8. study design prospective, single-centre, observational clinical study. 9. disease or disorder under study healthy people in risk of covid-19 infection. 10. main variable. symptoms related to infection caused by sars-cov2. 11. study population and total number of patients men and women in general god health status aged between 18 and 80 years that currently are employees of hospital de la princesa . 12. duration of treatment each subject will be monitored, since its recruitment, for a period of 12 weeks. 13. timetable and expected date of completion the overall duration of the study is estimated at about 6 months, from patient recruitment to the last data recorded by last subject. the aim is to carry out this study from march 2020 onwards.


Eligibility criteria:
inclusion criteria: 1. male or female subject age ≥ 18 years. 2. the subject has no symptoms in last week of covid-19 infection such as: * body temperature ≤ 37, 1 ºc. * normal lung and breath functions. 3. the subject belongs to the hospital de la princesa workforce. exclusion criteria: 1. people with any symptom suspicious of covid-19 infection.
multicenter study on laparoscopic versus open panp-tme for male mid-low rectal cancer patients

Conditions: Rectum Neoplasms

Summary: tme (total mesorectum excision) is the golden standard of radical resection for mid-low rectal cancer. however, the damage of pelvic autonomic nerve following with tme principle will lead to high incidence of urinary and sexual function disorder. open panp (pelvic autonomic nerve preservation) tme surgery played a role in decreasing incidence of urinary and sexual function disorder. however, 32%-44% patients still suffered from urinary and sexual function disorder when underwent open panp tme surgery (o-panp-tme). laparoscopy-assisted tme surgery (l-tme) is applied wildly nowadays. in the early stage of work, we performed laparoscopy-assisted panp tme surgery (l-panp-tme) to discuss the protection of urinary and sexual function of male mid-low rectal cancer patients. the results showed that l-panp-tme significantly decreased incidence of urinary and sexual function disorder. in order to further confirm our early work, we design a multiple-center randomized controlled clinical trial to compare differences in urinary and sexual function protection and long-term outcomes between l-panp-tme and o-panp-tme.


Eligibility criteria:
inclusion criteria: * age from over 20 to under 60 years * primary rectal adenocarcinoma confirmed pathologically by endoscopic biopsy * mid-low rectal cancer (distance from anal edge≤12cm); ct1-3, n0-3, m0 at preoperative evaluation according to the ajcc cancer staging manual seventh edition * expected curative resection through both l-panp-tme and o-panp-tme; performance status of 0 or 1 on ecog (eastern cooperative oncology group) scale * asa (american society of anesthesiology) score class i, ii, or iii; written informed consent * urinary and sexual function normal preoperatively exclusion criteria: * women during pregnancy or breast-feeding * severe mental disorder * history of previous pelvic surgery * enlarged or bulky regional lymph node diameter over 3cm by preoperative imaging * history of other malignant disease within past five years * history of unstable angina or myocardial infarction within past six months * history of cerebrovascular accident within past six months * history of continuous systematic administration of corticosteroids within one month * contraindication of heart, brain, lung, etc dysfunction * requirement of simultaneous surgery for other disease * emergency surgery due to complication (bleeding, obstruction or perforation) caused by rectal cancer * rectal cancer invades surrounding tissues * existence of genuine incontinence or severe stress incontinence preoperatively
comparison of rice based-meal on functional constipation in young korean women

Conditions: Functional Constipation

Summary: this study was conducted to investigate the effects of rice based-meal on functional constipation in young korean women.

studies comparing and evaluating the effects of a rice-based diet and a wheat-based diet on bowel movements are insufficient. in summary, efficient measures are needed to help individuals consume enough dietary fiber from natural sources in daily life to improve their bowel movements, rather than to consume a fiber supplements separated or synthesized from a particular natural food. in this study, investigators compare and evaluate the effects and safety of eating rice-based diets (brown rice-based and white rice-based) and a wheat-based diet in terms of bowel health and bowel movements among young women with functional constipation.

Eligibility criteria:
inclusion criteria: * age of 19 to 30 years females * meet of rome ⅲ diagnostic criteria of functional constipation * ability to give informed consent exclusion criteria: * subject with a history or evidence of clinically significant gastrointestinal, anorectal, hepatic, renal, neurological, pulmonary, endocrine, blood tumor, psychiatric, cardiovascular disease * subjects who have a gastrointestinal (gi) disease (crohn's disease, etc.) that would increase the influence with absorbance medication or a gi surgery excluding appendectomy and hernia surgery * known history of moderate to severe hepatic impairment (i.e., serum alt\>1.5×uln, ast\>1.5×uln) * subjects with significant hypersensitivity about brown rice, polished rice, wheat, milk * regular ingestion of probiotic products * subjects who received certain medications that cause the alteration of bowel movement within the past 2weeks prior to first administration * subjects who participated in other clinical investigation within 2 months prior to first administration * subject who drink constantly (21 units/week over) * subject who are pregnant or breast feeding * subject who have irritable bowel syndrome by rome ⅲ criteria * any significant condition that, in the opinion of the investigator, could interfere with the subject's participation or compliance in the study(i.e., laboratory test and others)

Keywords: functional constipation brown rice based-meal polished rice based-meal wheat based-meal
the protection of thyroid function in imrt for nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma; Nasopharyngeal Cancer; Hypothyroidism

Summary: this study aimed to reduce radiation-induced thyroid injury without compromising control of the cervical region by optimizing the delineation of the cervical lymph node drainage area.

since the neck target area of nasopharyngeal carcinoma is close to the thyroid gland, the average dose to the thyroid gland is usually around 54gy, which is difficult to meet the protection requirements for thyroid protection. in the current guidelines, the inner edge of the common carotid artery is used as the inner boundary of the lymph nodes in levels iii and iva, and the lymphatic drainage area needs to include the inner edge of the common carotid artery. several studies have found that the centers of positive lymph nodes in cervical regions iii and iva are located outside the inner border of the common carotid artery. in order to better protect the thyroid gland, the investigators have improved the delineation of the neck target area. for patients with negative lymph nodes in regions ii and iva (accounting for about 60% of the total patients), a modified neck target volume delineation method was used to define the inner boundary of regions iii and iva as the outer edge of the common carotid artery. for patients with positive lymph nodes in regions iii and iva (accounting for about 40% of the total patients), the inner boundary of regions iii and iva is defined as the inner edge of the common carotid artery or the outer edge of the thyroid. this study aimed to reduce radiation-induced thyroid injury without compromising control of the cervical region by optimizing the delineation of the cervical lymph node drainage area.

Eligibility criteria:
inclusion criteria: 1. the pathological diagnosis was newly diagnosed non-keratinizing squamous cell carcinoma nasopharyngeal carcinoma. 2. the clinical stage is t1-4n0-3m0 (stage i\~iva, uicc/ajcc 8th edition); 3. there is no history of hypothyroidism or hyperthyroidism before treatment; 4. using intensity-modulated radiotherapy technology, 5. complete radical dose radiotherapy; 6. kps≥70 points; 7. age 18-70 years old; 8. male or female who is not pregnant or lactating; 9. hematological examination: white blood cells \> 4×109/l, neutrophils \> 2×109/l, hemoglobin \> 90g/l, platelets \> 100×109/l; 10. liver function: alt, ast \< 1.5×uln, alp \< 2.5×uln, bilirubin \< uln. 11. renal function: creatinine \> 60 ml/min; 12. the patient signs the informed consent form; exclusion criteria: 1. who pathological classification is keratinizing squamous cell carcinoma or basaloid carcinoma; 2. palliative treatment; 3. have a history of other malignant tumors; 4. pregnant or lactating women (women of childbearing age should consider taking a pregnancy test, and patients are required to use effective contraception during treatment); 5. have a history of neck surgery; 6. have a history of hyperthyroidism or hypothyroidism. 7. previous history of head and neck radiation therapy;
dose finding study to assess safety and efficacy of stem cells in liver cirrhosis

Conditions: Alcoholic Liver Cirrhosis

Summary: this study will evaluate the safety and efficacy of mesenchymal stem cells in patients with cirrhosis of liver. stem cells will be injected into the hepatic artery. improvement in various parameters will be observed over 2 years.


Eligibility criteria:
inclusion criteria: * alcoholic cirrhotics between 18-65 years of age (diagnosed by clinical, biochemical, sonographic, radiological \[ct scan\] or histological evidence of cirrhosis and portal hypertension). * evidence of decompensated liver disease at screening (e.g. child class b or c, child-pugh scores of ≥7 and \<14). * meld scores of at least 10 (unos meld calculator). * normal afp level * hb\>10gm/dl. * female patients of childbearing age must be willing to use accepted methods of contraception during the course of the study * signed informed consent. exclusion criteria: * patients likely to undergo liver transplantation during the duration of the study. * presence of advanced hepatic encephalopathy grades 3 \& 4 (west haven criteria for grading of hepatic encephalopathy) at the time of screening * active variceal bleed. * refractory ascites. * evidences of autoimmune liver disease- ana or anti-lkm positivity. * platelet count \< 30,000/mm3. * serum sodium \<129meq/l. * serum creatinine \> 2 mg/dl. * hepatocellular carcinoma or other malignancies * active infectious disease. * presence of severe underlying cardiac, pulmonary or renal disease. * excessive alcohol (\>30 gm of alcohol/day) use in the last 3 months before screening. * positive hbsag or antibodies to hiv or hcv. * pregnancy or lactation. * participation in other clinical trials. * unwilling/unable to sign the informed consent.

Keywords: alcoholic liver cirrhosis stem cells
effects of cycling dual-task in parkinson's disease.

Conditions: Parkinson Disease

Summary: taking into account the process of functional and cognitive evolution that patients with parkinson's disease experience throughout the evolution of the pathology, the objective of this study is to evaluate the effect of a dual-task program combining cognitive tasks and forced cycling on the functional and cognitive capacity of these patients.


Eligibility criteria:
inclusion criteria: * parkinson disease * hoehn and yahr 1 and 2 exclusion criteria: * hoehn and yahr \>2
clinical applications of (s)-[18f]fbfp pet/ct in healthy volunteers and patients with central nervous system diseases

Conditions: Patients With Central Nervous System Diseases

Summary: this is an open-label whole-body pet/ct (positron emission tomography/computed tomography) study for investigation of radiation dosimetry, plasma pharmacokinetics, biodistribution, safety and diagnostic performance of (s)-\[18f\]fbfp in healthy volunteers and patients with central nervous system diseases. a single dose of nearly 370 mbq (s)-\[18f\]fbfp will be intravenously injected into healthy volunteers and patients with central nervous system diseases. visual and semiquantitative method will be used to assess the pet/ct images. changes of blood pressure, pulse, respiration, temperature and any adverse events will be collected from the volunteers. adverse events will also be observed in the patients.

(s)-\[18f\]fbfp is a promising sigma-1 receptor radioligand. the sigma-1 receptor is a unique chaperone protein with 223 amino acids located at the mitochondria-associated endoplasmic reticulum membrane. several lines of evidence have demonstrated that the sigma-1 receptor plays a pivotal role in the pathophysiology of many neuropsychiatric disorders including amyotrophic lateral sclerosis, alzheimer's disease, parkinson's disease, huntington's disease, pain, depression and drug addiction.therefore, it is an important target for the investigation of neuropsychiatric disorders and drug development. pet imaging of sigma-1 receptors in the human brain will enable the elucidation of this target's involvement in neurologic disorders and will also facilitate new drug development. for further interests in clinical translation of pet sigma-1 receptors radioligands, (s)-\[18f\]fbfp, an open-label whole-body pet/ct study was designed to investigate radiation dosimetry, plasma pharmacokinetics, biodistribution, safety and diagnostic performance of (s)-\[18f\]fbfp in healthy volunteers and patients with central nervous system diseases.

Eligibility criteria:
inclusion criteria: * healthy volunteers: males and females, ≥18 years old * patients with central nervous system diseases: patients with suspicion or diagnosis of central nervous system diseases after systemic neuropsychiatric assessment by experienced neurologists, having other imaging examination like ct or mri, being able to provide basic information and sign the written informed consent form. exclusion criteria: * females planning to bear a child recently or with childbearing potential * known severe allergy or hypersensitivity to \[18f\] radionuclides. * kidney or liver failure. * patients not able to enter the bore of the pet/ct scanner. * inability to lie still for the entire imaging time because of cough, pain, etc. * concurrent severe and/or uncontrolled and/or unstable other medical disease that, in the opinion of the investigator, may significantly interfere with study compliance.
impact of lower urinary tract dysfunction on clinical manifestation in patients with stroke

Conditions: Lower Urinary Tract Symptoms

Summary: the course of post-stroke bladder problems and their relation with functional, mental status and quality of life: a six-month prospective, multicenter study

lower urinary tract symptoms is a broad term of subjective urinary symptoms such as nocturia, urgency, urinary incontinence, and frequency of voiding, defined by the international continence society. several disorders and conditions affecting the nervous system that controls the lower urinary system can result in neurogenic lower urinary tract dysfunction (lutd). stroke is one of these conditions. the literature review reveals that there is insufficient data regarding the course of lutd symptoms other than urinary incontinence in stroke patients, and their relation with functional and mental status. the aim of this prospective, multi-center study was to determine the frequency and course of post-stroke lutd from early term up to a period of six months, and to investigate the relation of lutd with functional and mental status and quality of life in stroke patients. this study was designed as a prospective study and included 70 stroke patients enrolled by the neurogenic bladder study group from five different centers across turkey. the demographic (age, sex, education, marital status and occupation) and clinical characteristics (side of the stroke, cause of the stroke, stroke localization and anticholinergic medication use) of the patients were obtained from the patient files and through face-to-face interviews. in addition, patients were questioned on the post-stroke 1st, 3rd, and 6th months in terms of bladder drainage methods (normal spontaneous urination, use of adjunct maneuvers such as crede, valsalva and tapping, presence of overflow, clean intermittent catheterization use, permanent catheter use) after stroke. the patients were questioned using the danish prostatic symptom score (dan-pss), and evaluated using the brunnstrom motor staging (hand, upper and lower extremities), modified barthel index, incontinence quality of life questionnaire (i-qol), and the mini-mental test (mmt) on the 1st, 3rd and 6th months.

Eligibility criteria:
inclusion criteria were as follows: 1) a recent (one month) stroke in medically stable patients and 2) being older than 18 years. exclusion criteria were as follows:eria: 1) presence of a history of a prior cerebrovascular disease, 2) presence of a concurrent neurological disorder, 3) presence of an acute systemic disorder or a concomitant disease that could affect urination problems, 4) history of urinary system problems before stroke, and 5) patients incapable of answering questions due to any reason.

Keywords: stroke lower urinary tract dysfunction functional status mini mental test
use of propranolol hydrochloride in the treatment of metastatic sts

Conditions: Malignant Soft Tissue Sarcoma

Summary: fifty patients with pathological proof of malignant soft tissue sarcoma will receive anthracyclin based chemotherapy combined with propranolol 40 mg twice daily. * the primary end point : to assess progression free survival (pfs) * the secondary end points : to assess overall survival (os) and toxicity profile


Eligibility criteria:
inclusion criteria: 1. histologic or cytologic diagnosis of malignant soft tissue sarcoma. 2. ecog less than or equal to 2 . 3. measurable disease according to the requirements of modified recist criteria. 4. age ≥ 19 years . 5. estimated life expectancy of at least 12 weeks . 6. adequate bone marrow reserve (white blood cells \[wbc\] ≥ 3.5 × 109 /l, neutrophils ≥ 1.5 × 109 /l, platelets ≥ 100 × 109 /l, and hemoglobin ≥ 9.0 gm/dl). exclusion criteria: 1. inadequate liver function (bilirubin \> 1.5 times upper normal limit \[unl\] and alanine transaminase \[alt\] or aspartate transaminase \[ast\] \> 3.0 unl or up to 5.0 unl in the presence of hepatic metastases). 2. inadequate renal function (creatinine \> 1.25 times unl, creatinine clearance \< 50ml/min). 3. serious concomitant systemic disorder incompatible with the study. 4. second primary malignancy (except in situ carcinoma of the cervix, adequately treated basal cell carcinoma of the skin, t1 vocal cord cancer in remission, or prior malignancy treated more than 5 years prior to enrollment without recurrence). 5. pregnancy

Keywords: efficacy propranolol hydrochloride sts