Kornimate/medical-research-clean huggingface dataset:
sit-to-stand training for survivors of stroke in a long-term care setting

Conditions: Cerebrovascular Accident

Summary: the purpose of this study is to see if providing training using a sit-to-stand protocol for residents of long-term care facilities who have had a stroke will increase their independence in performing sit-to-stand.

the implementation of a sit-to-stand protocol and extra practice has been previously validated in a rehabilitation setting, where 68% of survivors of stroke who received the training, learned to stand safely and independently from a 16" surface (the height of a regular toilet). our findings have been supported by other research that have shown that rising from sitting is a maneuver that has been advocated for strengthening the lower extremities of elderly individuals and patients with specific disorders such as stroke. during the acute care and rehabilitation phases, considerable effort is spent to maximize a person's functional abilities following a stroke; however, continued strengthening and activity appears to stop once an individual is admitted to a ltc facility. the main purpose of this randomized controlled trial is to examine the efficacy of implementing the sit-to-stand (sts) protocol with or without extra sit-to-stand practice for survivors of stroke residing in long-term care (ltc) facilities on (1) their ability to learn how to stand safely and independently from a 16" surface; (2) the number of staff injuries; (3) the number of residents' falls; (4) the quality of life of the residents and staff; and (5) the translation and maintenance of knowledge of the sts protocol by staff into their daily routines.

Eligibility criteria:
inclusion criteria: * diagnosis of cerebrovascular accident * reside in long-term care facility * have physician approval to participate in the study * are unable to stand up independently from a 16" surface without using their hands * have given informed consent exclusion criteria: * expect to be leaving the facility in less than 24 weeks * have a terminal illness * have a total hip replacement or other orthopedic complication that prevents them from being able to safely use protocol * have pain that prevents their participation * are at higher risk for falling (i.e. blood pressure disorder/postural hypotension, vestibular disorder)

Keywords: long-term care clinical protocols sit-to-stand
outpatient versus inpatient balloon catheter induction of labor

Conditions: Prolonged Pregnancy

Summary: randomized trial comparing double balloon catheter for induction of labor between in- and outpatient groups.investigators assess feasibility, clinical effectiveness and patient acceptability of outpatient versus inpatient catheter for induction of labor.

the objective of this study is to describe labor outcomes in women with double balloon induction catheter of labor. participants included are women with uncomplicated singleton pregnancy of ≥37- ≤41+5 weeks of gestation. patients are randomized to two groups: one hundred are randomized to the inpatient and one hundred to the outpatient group. the main outcome measure is the pain evaluated by vas at one, five, nine and 13 hours after the placement of double balloon induction catheter. the total hospital stay and induction to delivery interval time is measured. also the mode of birth as well as maternal and neonatal morbidity and patient satisfaction are recorded.

Eligibility criteria:
inclusion criteria: * uncomplicated pregnancy * singleton pregnancy * pregnancy weeks between \>37 and \<41+5 * the patient is living in 1/2 hour away from hospital exclusion criteria: * patient has any disease or medication * multiple pregnancy * pregnancy week \> 41+5 * preterm rupture of membranes * patient living more than 1/2 hour away from hospital

Keywords: induction of labor double balloon catheter mechanical ripening
iontophoretic transepithelial collagen cross-linking versus epithelium-off collagen cross-linking in pediatric patients. three year follow up.

Conditions: Keratoconus

Summary: to compare 3 year iontophoretic transepithelial corneal cross-linking (i-on cxl) outcomes with epithelium-off collagen cross-linking (epi-off cxl)in pediatric patients.

forty eyes of 28 consecutive pediatric patients (mean age 14.3±2.5 \[sd\] years; range, 9 to 18 years) with keratoconus were enrolled in the study. twenty eyes of 15 patients underwent i-on cxl, while 20 eyes of 13 patients underwent epi-off cxl. corrected distance visual acuity (cdva), spherical equivalent, maximum keratometry (kmax), posterior elevation of the thinnest point and thickness of the thinnest point mean values were evaluated. a student t test was used to compare baseline and 12, 24, and 36 month postoperative data. keratoconus progression in function of preoperative kmax value and cone location was evaluated at 36 months.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of keratoconus age \< 18 years at the treatment; corneal cross linking performed at least 3 years before exclusion criteria: * age \> 18 years at the treatment
epidemiological study to describe nsclc clinical management patterns in europe. lung-epiclin

Conditions: NSCLC

Summary: to provide accurate and reliable information regarding nsclc clinical management across european countries in order to detect unmet medical needs of this disease in terms of: patient and hospital characteristics; diagnostic and treatment approaches: initial and subsequent, follow-up patterns in clinical management; outcomes: symptoms, death, functionality, quality of life; use of resources and burden on patients and health care systems.


Eligibility criteria:
inclusion criteria: * confirmed nsclc diagnosis (e.g. bronchoscope or fnab), all stages, men and women, attending the responsible department of treating this type of patients for the first time between january 1st, 2009 and march 31st, 2009. * for pro sub-sample: ability to read and write since they will be asked to participate in the pro part of the study. selection will not be based on the disease stage of each patient, in order to avoid a selection bias. exclusion criteria: * according to the study design there will not be any exclusion criteria in order to provide a high external validity and to obtain the most accurate real daily practice information.

Keywords: lung cancer nsclc management nsclc use of health care resources
bronchospasm during anesthetic induction: study of clinical characteristics and treatments administered according to etiology

Conditions: Bronchospasm

Summary: bronchospasm during anaesthesia is a rare but potentially life-threatening event. they are classically part of ige-dependent anaphylaxis but can also occur as an independent clinical entity, triggered by inflammatory factors such as smoking, chronic bronchitis, asthma, overweight and mechanical factors such as tracheal intubation. the etiological diagnosis is currently established during an allergy-anaesthesia consultation after skin testing for drugs used for induction of anaesthesia and antibiotic therapy when it is attributable. the aim of this study was to determine the characteristics that differ between 2 groups: isolated non-allergic bronchospasm and bronchospasm as part of an immediate allergic hypersensitivity reaction.


Eligibility criteria:
inclusion criteria: * patients referred to the allergy consultation for investigation of an immediate hypersensitivity reaction, involving a bronchospasm explicitly identified by the anaesthetist, which occurred during an anaesthetic procedure. exclusion criteria: * none

Keywords: bronchial spasm general anaesthesia allergy anaphylaxis
neural changes in the aging auditory system

Conditions: Progesterone; Estrogens; Hearing; Psychoacoustics; Auditory Perceptual Disorders

Summary: the purpose of this study was to determine the effects of hormone replacement therapy (hrt) on hearing in post-menopausal women.

background: female hormone influences on the development and aging of the auditory system are not completely understood. the present study retrospectively analyzed and compared hearing abilities among post-menopausal women taking hormone replacement therapy (hrt), treated with estrogen and progesterone (e+p); estrogen alone (e), and a third (control - nhrt) group, matched for age, who did not receive any hrt. methods: 126 subjects, (60-86 yr), n=32, e+p; n=31, e; n= 63, nhrt; matched for age and health status participated. all had relatively healthy medical histories, absence of significant noise exposure, middle ear problems, major surgeries or current/heavy smoking. hearing tests included pure tone audiometry (pta), tympanometry, distortion-product otoacoustic emissions (dpoaes), transient otoacoustic emissions (teoaes) and hearing-in-noise-test (hint). the latter is a test for speech perception in background noise: the major complaint of hearing-impaired persons. .

Eligibility criteria:
inclusion criteria: * healthy middle ears exclusion criteria: * ototoxic medications * serious medical health problems * neurological conditions * meniere's disease or labyrinthitis * those who failed cognitive screening tests (mini-mental test) * current/heavy smokers * conductive hearing loss * history of noise damage and/or audiograms signifying noise damage * poor speech discrimination scores (80% or less)

Keywords: hearing loss, central presbycusis hearing loss, sensorineural hearing loss, cochlear hearing loss, bilateral sex steroid hormones estradiol
a prospective pilot study of the op-1 putty in uninstrumented posterolateral fusions

Conditions: Degenerative Lumbar Spondylolisthesis

Summary: this study will explore the use of op-1 putty in conjunction with surgical treatment for the treatment of spinal decompression and lumbar spinal fusion.

it is postulated that the addition of op-1 putty to autogenous bone will prove beneficial in the treatment of patients requiring decompression and lumbar spinal fusion. the investigational system is intended to stimulate bone growth. it is indicated as an adjunct or a replacement for autograft in spinal fusion.

Eligibility criteria:
inclusion criteria: 1. the subject has a diagnosis of degenerative lumbar spondylolisthesis of grade i or ii with spinal stenosis demonstrated by medical history, physical examination a n d radiographic imaging. 2. the subject is a candidate for decompression and spinal fusion with the use of autograft from the iliac crest. 3. the subject requires one level lumbar fusion (l-3 to s-1). 4. the subject has a preoperative oswestry disability index of 30-100. exclusion criteria: 1. the subject has active spinal and/or systemic infection. 2. the subject is morbidly obese. 3. the subject has a known sensitivity to any component of the op-1 putty. 4. the subject has spinal instability measured on flexion / extension radiographs of greater than 50% translation of the vertebrae and greater than or equal to 20 degrees of angular motion. 5. the subject uses tobacco or nicotine or is prescribed steroids such as cortisone.

Keywords: degenerative disc disease
effects of crossover point exercise on depression, anxiety and stress in chinese postmenopausal women

Conditions: Mental Health

Summary: to analyze the effects of the crossover point (cop) exercise program on chinese postmenopausal women.

this is a randomized clinical trial of single-blind with 2 arms (control group and experimental group), in which a pre-treatment-posttest design has been used.

Eligibility criteria:
inclusion criteria: * postmenopausal women without incapacitating chronic disease or contraindications to exercise * baseline mental health * no severe chronic diseases or exercise contraindications * ability to understand the research details and voluntarily sign the informed consent form. exclusion criteria: * women with undetermined menopause； * bmi \ 28 kg/m2 * uncontrolled hypertension (systolic blood pressure \>160 mmhg and/or diastolic blood pressure \>110 mmhg) * life-threatening illness with a prognosis of \<5 years * currently receiving estrogen therapy * currently taking medication that may affect psychological testing * contraindications to exercise

Keywords: mental health sleep quality exercise body composition body image
evaluation of t2, t3 sympathectomy for postmastectomy pain syndrome by pulse oximeter

Conditions: Analgesia

Summary: the aim of the study is to compare the efficacy of t2, t3 sympathetic block using thermal radiofrequency versus chemical neurolysis in postmastectomy pain syndrome using perfusion index derived from pulse oximetry.

postmastectomy pain is a chronic pain condition with neuropathic nature. several drugs and methods are used for its management. this study was designed to compare the efficacy of both thermal radiofrequency and chemical neurolysis in management of postmastectomy pain through using perfusion index derived from pulse oximetry.

Eligibility criteria:
inclusion criteria: * female patients with postmastectomy pain syndrome * ≥ age 18 years * asa ii-iii exclusion criteria: * patient refusal * coagulation defects * abnormal kidney or liver functions * local infection at site of injection * bone metastases * severe cardiorespiratory disease
an observational study of fungal biomarkers (mk-0000-089)

Conditions: Aspergillosis

Summary: the purpose of this study is to evaluate the relationship between fungal biomarker levels during anti-fungal therapy and the success of treatment for fungal infection. the primary hypothesis is that over the initial two weeks of anti-fungal therapy, fungal biomarkers from participants with invasive aspergillosis (ia) will be lower for those with a successful clinical outcome compared to those with a failed clinical outcome.


Eligibility criteria:
inclusion criteria: * is 16 years of age or older * female is either post-menopausal, surgically sterilized, willing to use 2 adequate methods of birth control, or agrees to abstain from heterosexual activity throughout the study * female of child bearing potential must have a negative pregnancy test * male is surgically sterilized, agrees to use an adequate method of contraception, or agrees to abstain from heterosexual activity for the duration of the study * has possible, probable, or confirmed invasive aspergillosis (ia) * has had a computed tomography (ct) or magnetic resonance imaging (mri) scan 72 hours prior to initiation of anti-fungal therapy exclusion criteria: * has had hemodialysis using cellulose membrane within 2 weeks of study start
stepwise approach to substrate modification for ventricular tachycardia

Conditions: Ventricular Tachycardia; Catheter Ablation; Tachycardia, Ventricular

Summary: the goal of this trial is to test the impact of a step-wise approach for catheter ablation of recurrent ventricular tachycardia, (irregular heart rhythms that originate in the bottom chambers of the heart), in patients with a previous heart attack for whom catheter ablation is clinically indicated.

sudden cardiac death due to vt (ventricular tachycardia) or vf (ventricular fibrillation) occurs at an estimated rate of 300,000 events per year in united states, accounting for 5.6% of annual mortality22. a significant proportion of patients treated with icds (implantable defibrillators) will receive shocks due to recurrent vt, resulting in increased mortality8. as a result, catheter-based ablation has emerged as an effective treatment for recurrent vt. however, no study has assessed the impact of a step-wise approach on the outcome of catheter ablation of vt. the investigators propose a prospective, multicenter, non-randomized, single-arm trial to evaluate the impact of a step-wise approach to catheter ablation on ventricular tachycardia recurrence. given the increasing use of catheter ablation in patients with recurrent ventricular tachycardia, this study will answer a critical question regarding the impact of a step-wise approach on the inducibility of vt at the end of the procedure and clinical recurrences of ventricular arrhythmias at 6 months.

Eligibility criteria:
inclusion criteria: * age 18 to 90 years. * history of coronary artery disease. * presence of, or planned for, an icd prior to discharge. * presentation for management of icd shock/atp therapy or monomorphic ventricular tachycardia. exclusion criteria: * ventricular arrhythmia not thought to be due to cad. * unstable angina * cva within 30 days. * protruding left ventricular thrombus or critical aortic stenosis on pre-ablation echocardiography * pregnancy * any condition resulting in an absolute contraindication to anticoagulation * inability to follow-up at icd clinic. * inability to give informed consent. * non-inducible for sustained monomorphic ventricular tachycardia. * prior substrate guided ablation. * definite need for epicardial ablation, as determined by the primary operator.

Keywords: ventricular tachycardia catheter ablation vt
effect of antihypertensive drugs on glaucoma patients

Conditions: Glaucoma

Summary: it has been reported that among asian non-glaucomatous, antihypertensive medications were associated with retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness. in order to explore whether antihypertensive medications would influence the neuropathy among glaucomatous population, we designed a cross-sectional observational study to analyze the retinal status among glaucoma patients with use of antihypertensive medication.

we designed a cross-sectional obeservational study to analyze the retinal status among glaucoma patients with use of hyertensive medication.

Eligibility criteria:
inclusion criteria: * age no less than 18 years * best corrected visual acuity better than decimal 0.3 exclusion criteria: * secondary glaucoma * secondary hypertension * glaucoma-related operation history * pregnancy or lactation period * uncooperative with retinal examination * severe opacity with refracting media in eye * severe retinal diseases and neuropathy * congenital retinal optic nerve abnormality * other systemic diseases that influence hypertension and glaucoma assessment
prevent: perometer visualization to end treatment-related lymphedema

Conditions: Lymphedema

Summary: this research study is to learn about breast cancer patients' opinions about screening for lymphedema (a side effect of breast cancer treatment in which the arm can become heavy, painful, and/or swollen) and their satisfaction with the lymphedema screening program.

primary objectives: * to determine the effectiveness of prospective, intensive lymphedema screening in the postoperative setting using a perometer for reducing the cumulative incidence of grade lymphedema among breast cancer patients after alnd compared to routine screening. secondary objectives: * to estimate the direct costs associated with the lymphedema screening initiative * to determine the association of the initiative on patient productivity * to determine patient satisfaction with the lymphedema initiative in the context of their cancer care * to determine patient understanding of lymphedema-associated symptoms * to determine patient self-reported compliance with treatments and measures to prevent lymphedema * to determine the incidence of breast cancer-related lymphedema among a cohort of breast cancer patients treated with alnd to analyze clinical and pathological features associated with the development of lymphedema

Eligibility criteria:
inclusion criteria: a cohort a: * breast cancer patients with a baseline (preoperative perometer measurements) who have undergone axillary lymph node dissection * english speaker * patients who participate in cohort a will be eligible for enrollment in cohort b cohort i: * breast cancer patients who have undergone axillary lymph node dissection who have a clinic visit in the nellie b. connally breast center approximately 12 months (+/- 4 months) following axillary lymph node dissection * english speaker c cohort ii: * breast cancer patients who have undergone axillary lymph node dissection who are having a follow-up visit in the nellie b. connally breast center within 0-6 months following surgery who intend to continue follow-up care at md anderson * english speaker exclusion criteria: inability to complete a self-administered questionnaire
intraoperative functional ultrasound

Conditions: Brain Tumor; Brain Lesion

Summary: a wide spectrum of methods is used to image brain activation in vivo. it can be directly detected by neurons electrical activity imaging (cortical simulation mapping, calcium imaging, voltage sensitive dyes) or indirectly by imaging hemodynamic changes induced by the neurovascular coupling in the vessels surrounding the activated neurons (intrinsic optical imaging, photoacoustic imaging, positron emission tomography (pet), functional magnetic resonance imaging (fmri)). ultrasound as the potential to complement these functional imaging techniques at low cost. ultrasound imaging can do real-time in-depth imaging of brain. however, its use to imaging of major vessels has been limited until now due to its poor sensitivity. to overcome this limitation functional ultrasound (fus) was developed in institut langevin since 2011. this technique enables high spatio-temporal resolution imaging of whole-brain microvasculature dynamics in response to brain activation without the need of contrast agent. this fus method relies on a new power doppler imaging sequence sensitive enough to detect blood flow in most of cerebral vessels (arterioles, big venules and larger vessels). repeating the acquisition of such ultrasensitive doppler images over time enables to follow flow dynamics in such vessels modulated by local neuronal activity. applied to the rat brain, fus was proved able to map brain activation at high spatiotemporal resolution and high signal to noise ratio. the aim of this study is now to apply fus on human brain in intraoperative condition. the main objective of this study is to find activation maps through intraoperative ultrasensitive doppler compared to gold standard cortical simulation mapping and functional mri. secondly the investigators want to test sensitivity of this new doppler mode. fus method will be used for different types of stimuli and intensity and the investigators will do some control acquisitions. blood vessel density observed with a conventional doppler will be compared to the one measured with the ultrasensitive doppler to prove that this new doppler mode enhance micro vessel visualization.


Eligibility criteria:
inclusion criteria: * men and women, adults ( \> 18 years old) * participants who have to undergo brain surgery, awake or under general anesthesia, for tumor or lesion resection (all types of tumors and lesions, cortical or subcortical), with programmed intraoperative ultrasound and cortical simulation mapping. * consent form signed by the patient after being informed (written and oral) of the research protocol. * patient affiliate to the social welfare system exclusion criteria: * minors ( \< 18 years old) * pregnant, parturient or breastfeeding women * protected persons, under guardianship, or under any administrative or legal right and liberty revocation procedure * patient without affiliation to the social welfare system

Keywords: functional ultrasound intraoperative brain doppler ultrasound