Kornimate/medical-research-clean huggingface dataset:
bone metastases database of patients treated surgically for impending or pathologic fracture of long bones

Conditions: Neoplasm Metastasis

Summary: the aims of this study are to collect prospective data on the natural history of bone metastases (bms) and skeleta related events (sres),

the aims of this study are to evaluate clinical and biological factors of patients with bms after reconstruction with intramedullary fixation (imn) or endoprosthetic reconstruction (epr) with a specific focus on (1) the rate of complication or failure; (2) differences in complication rates by anatomic site; (3) functional results as assessed by the musculoskeletal tumor society system (msts); (4) differences in complication rate between patients treated with inm versus epr; and (5) differences in survival in patients with metastatic bone disease based on disease-specific, laboratory, and demographic information.

Eligibility criteria:
inclusion criteria: * patients with long bone metastases treated surgically with intramedullary nail or endoprosthetic reconstruction exclusion criteria: * patients with bone metastases of the spine
masticatory side-switch and mixing ability.

Conditions: Chewing Problem; Mastication Disorder

Summary: the main aim of this cross-over intervention study is to assess the effect of masticatory side-switch frequency on different aspects of masticatory function, including masticatory mixing ability and rhythm. a secondary aim is to explore the subjective perception of taste, muscular fatigue, and saliva production through a vas. thirty-six volunteers recruited for convenience, among students of the degree of dentistry of the faculty of medicine and health sciences of the university of barcelona, will perform 6 tests, each consisting of 2 assays, chewing a two-coloured chewing gum, during 40 masticatory cycles. the tests will be randomised masticatory sequences of "free-style", "unilateral-right", "unilateral-left", switching the chewing side at 5% "g05", at 15% "g15" and at 25% "g25". video recordings of these tests will be made to later assess, on slow playback, the change of the chewing side and the masticatory rhythm. the masticatory mixing ability will be determined through the scanning and posterior analysis of the red-channel in the histogram plug-in in "imagej" (r).

this this cross-over intervention study aims to assess the effect of masticatory side-switch frequency on different objective aspects of masticatory function, including masticatory mixing ability and rhythm, as well as the subjective perception of taste, muscular fatigue, and saliva production through a vas. each of the thirty-six volunteers recruited for convenience, among students of the degree of dentistry of the faculty of medicine and health sciences of the university of barcelona, will perform 6 tests, each consisting of 2 assays, chewing a two-coloured chewing gum, during 40 masticatory cycles. one test involves freestyle mastication in which the participant will be asked to masticate the chewing gum. two tests involve chewing the gum unilaterally (i.e., only on the right-hand side, and only on the left) varying the order of these assays. in the last three tests, the volunteer will switch chewing side in 5% (g05), 15% (g15), or 25% (g25) respectively; the sequence of the assays will be randomized. twenty-four of these volunteers will be randomly selected to repeat these tests after a period of two weeks. the masticatory mixing ability will be determined through the "mixing capacity index" (mci), obtained from through the scanning and posterior analysis of the red-channel in the histogram plug-in in "imagej" (r), and the masticatory rhythm will be assessed through the masticatory frequency as the ratio of masticatory cycle number to masticatory time. the control variables will include age and sex.

Eligibility criteria:
inclusion criteria: * older than 18 years old. * natural dentition (minimum 24 teeth) exclusion criteria: * active orthodontics treatment. * intraoral pain. * temporomandibular joint pain. * masticatory muscle pain. * large dental restorations. * dental prosthesis. * edentulous spaces.

Keywords: chewing side masticatory side-switch mastication masticatory rhythm masticatory performance masticatory mixing ability
comparison of methotrexate versus interferon-alfa 2b in patients with primary cutaneous t-cell lymphomas

Conditions: Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides

Summary: comparison of methotrexate versus interferon-alfa 2b on efficacy, safety and quality of life in patients with primary cutaneous t-cell lymphomas after failure of topical or phototherapy treatment.

methotrexate and interferon are widely used drugs in treatment in patients with cutaneous t-cell lymphomas. efficacy and safety of both drugs have never been compared directly in one study. patients will be randomly assigned to receive methotrexate or interferon alfa 2b. treatment will continue until disease progression or the development of intolerable toxicities. study is conducted to analyse and compare efficacy, safety and quality of life provided by methotrexate or interferon alfa 2b.

Eligibility criteria:
inclusion criteria: 1. histologically confirmed primary cutaneous t-cell lymphoma (ctcl) 2. age ≥ 18 years 3. performance status who\<=2 4. subject must have adequate bone marrow, renal and hepatic function 5. topical and phototherapy treatment failure in the past 6. signed informed consent exclusion criteria: 1. subject has received prior systemic methotrexate or interferon therapy 2. unacceptable methotrexate or interferon treatment toxicity in the past 3. inadequate bone marrow, renal or hepatic function as follows: * bone marrow: absolute neutrophil count (anc) \< 1,500/mm 3 (1.5 × 10 9 /l); platelets \<100,000/mm 3 (100 × 10 9 /l); hemoglobin \< 9.0 g/dl (1.4 mmol/l); * renal function: creatinine \>1.5 x upper limit of normal (uln) * hepatic function: aspartate and alanine transaminase (ast and alt) \>3× uln; bilirubin \> 1.5 × uln * active hepatitis b or hepatitis c 4. anorexia 5. major depression with suicidal ideation or suicide attempt in the past 6. symptomatic congestive heart failure 7. epilepsia or other symptomatic central nervous system dysfunction 8. active skin infection not related to underlying ctcl, active tuberculosis, hiv infection 9. subject is pregnant or lactating 10. psychiatric illness/social situation that would limit compliance with study requirements

Keywords: mycosis fungoides cutaneous t-cell lymphoma interferon methotrexate
psychosocial intervention in assisted reproduction treatments

Conditions: Infertility Primary; Psychosocial Stressor; Anxiety Depression

Summary: the aim of the study was to evaluate and compare different strategies of psychosocial intervention for patients undergoing ivf treatment in a private fertility clinic. recruited patients were assigned to one of three groups: group intervention, couple intervention or no intervention (control group). three main variables were assessed: depression, anxiety and life quality.

a total of 87 couples have participated in this study. all couples were about to start an assisted reproduction treatment (artificial insemination or in vitro fertilization). couples were assigned to one of three study groups: group intervention, couple intervention or no intervention (control group). patients in the first group (group intervention) attended six group psychotherapy sessions. patients in the second group attended six psychotherapy sessions (particular sessions in this case). the patients in the third group received no psycho-social intervention. assignation to each group was not randomized, it depended on scheduling availability of the patients. patients attended one session every week or 15 days. each session lasted 90 minutes. sessions were designed to minimize the possible negative psycho -social impact of infertility and its treatment. different aspects were approached in these sessions including emotion expression, social coping, communication skills, emotion management in different social situations, identification of dysfunctional thoughts, cognitive restructuring, and cognitive distortions. the outcomes measured were: anxiety, depression, life quality, coping and perceived social support. these variables were assessed before art, after art and in a follow-up performed six months after art. psychological variables were assessed using different well-recognized inventories.

Eligibility criteria:
inclusion criteria: * childless couples * about to undergo an art treatment exclusion criteria: * undergoing art treatment when signing the informed consent of the study * pregnant when signing the informed consent of the study

Keywords: assisted reproduction treatment (art) psychology psychosocial intervention depression anxiety life quality
preliminary study of uterine healing after caesarean section: clinico-echographic and anatomopathologic correlation

Conditions: Assessment of Uterine Healing

Summary: caesarean section is one of the most common surgical procedures. the multiplication of uterine scars leads to an increase in complications and in particular those related to poor healing such as isthmocele or uterine rupture. the processes of uterine healing at the histological scale are little known. the main objective of the research is to analyze the process of uterine healing by means of uterine biopsies performed on the areas of cesarean section scars.

our hypothesis is that there is a histological healing defect visible on an anatomopathologic examination of the scar. this poor uterine healing on histological scale is probably associated with uterine healing defects visible on pelvic ultrasound (scar dehiscence) and clinical criteria (number of caesareans, symptoms). the objective of the research is to analyze uterine scarring by means of uterine biopsies performed on the areas of cesarean section scars. the uterine scarred areas will be analyzed histologically according to specific criteria and compared to healthy uterine areas. histological characteristics will be compared with clinical and ultrasound data.

Eligibility criteria:
inclusion criteria: * common to all groups: * adult patient, * signed consent for participation in the study * patient affiliated to a social security scheme (excluding ame) group 1: * support for a scheduled or emergency caesarean (excluding patients having an emergency caesarean (red code: caesarean within 15 minutes)) * scarred uterus: having already benefited from a caesarean section group 2: - surgical management of caesarean section scar dehiscence after a caesarean section group 3 (control): * support for a scheduled or emergency caesarean (excluding patients having an emergency caesarean (red code: caesarean within 15 minutes) * healthy uterus: no history of caesarean section (history of vaginal delivery or first pregnancy) exclusion criteria: * disorder of hemostasis at risk of bleeding * anatomopathological sampling not feasible * patient with a history of upper genital infections * patient under legal protection (guardianship, curatorship) * patient who does not speak or understand french * patient unable to answer questions or with difficulty in expressing herself

Keywords: uterine scarring isthmocele caesarean section
voriconazole and anidulafungin combination for invasive aspergillosis in pediatric subjects

Conditions: Aspergillosis; Invasive Pulmonary Aspergillosis; Neuroaspergillosis

Summary: this study aims to compare the safety, tolerability, and efficacy of voriconazole and anidulafungin in combination versus voriconazole alone in pediatric subjects aged 2 to 17 years with invasive aspergillosis.


Eligibility criteria:
inclusion criteria: * diagnosis of proven, probable, or possible invasive aspergillosis. * hematologic malignancy or allogeneic hematopoetic stem cell transplant. exclusion criteria: * sarcoidosis, aspergilloma, or allergic bronchopulmonary aspergillosis. * chronic invasive aspergillosis. * receipt of antifungal treatment for more than 96 hours. * severe liver dysfunction.

Keywords: aspergillosis combination therapy voriconazole anidulafungin
long term efficacy of neuronavigation guided rtms in alleviating gulf war illness related headaches and pain symptoms

Conditions: Gulf War Syndrome; Gulf War Illness; Headache; Muscle Pain; Joint Pain

Summary: this study aims to look at the long term efficacy of using repetitive transcranial magnetic stimulation (rtms) in relieving gulf war illness related headaches and pain.

headaches (ha), muscle and joint pain, are some of the most common debilitating symptoms in military personnel served in the 1990-1991 persian gulf war (gw1). migraine like ha and diffuse body pain were detected in 64% of gulf war veteran (gwv) diagnosed with gulf war illness (gwi). unfortunately, conventional pharmacological treatments for gwi-related pain has not been shown to be effective and drugs such as narcotics contain many long term untoward psychosomatic and abusive side effects. this study is assessing the effectiveness of repetitive transcranial magnetic stimulation (rtms), non-invasive treatment option, in alleviating headaches, muscle, and joint pain symptoms of gwi.

Eligibility criteria:
inclusion criteria: * male or female under 65 years of age who served in the military for at least 30 consecutive days between august 1, 1990, and july 31, 1991 in the persian gulf war region * center for disease control (cdc) criteria for gulf war illness (gwi) * kansas criteria for gwi * international headache society criteria for migraine headache without aura average headache exacerbation intensity \>3 on 0-10 a numerical pain rating scale (nps) * average overall daily muscle pain intensity \>3 on 0-10 a nps * average overall daily extremities joint pain intensity \>3 on 0-10 a nps * headache exacerbation/attack 3 times per week with the average intensity \>3 on a 0-10 nps, lasting \> 4 hours in the past three months * hamilton rating scale of depression (hrsd) \<14 based on the sum of scores for the first 17 items exclusion criteria: * pregnancy * history of pacemaker implant * any ferromagnetic (e.g. bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain mri * history of dementia, major psychiatric diseases, or life-threatening diseases * presence of any other chronic neuropathic pain states such as complex regional pain syndrome or painful peripheral neuropathy * history of seizure * pending litigation * low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy * lack of ability to understand the experimental protocol and to adequately communicate in english * history of traumatic brain injury * chronic tension or cluster headache * ongoing cognitive rehabilitation or treatment of ptsd

Keywords: rtms transcranial magnetic stimulation gulf war illness
efficacy and safety of combination diuretic therapy in patients with acute decompensated heart failure and volume overload

Conditions: Acute Decompensated Heart Failure; Volume Overload; Edema

Summary: this study aims to compare two medications, acetazolamide and metolazone, along with loop diuretics, to see which one works better and is safer for patients with adhf who have volume overload. by comparing these medications, we hope to learn which one can help these patients the most. this will help doctors choose the best treatment for patients with adhf and volume overload.


Eligibility criteria:
inclusion criteria: * male or female patients with ages ≥ 18 years old, and less than 65 years old. * for both elective and emergency hospital admissions, patients with a clinical diagnosis of adhf must exhibit at least one clinical sign indicative of volume overload. these signs may include edema (score 2 or higher), ascites confirmed through echography, or pleural effusion confirmed by chest x-ray or echography or rales on auscultation, or jugular venous pressure greater than10 mm hg. exclusion criteria: * patient diagnosed with acute kidney injury upon hospital admission based on the presence of any of the following criteria: an increase in scr by at least 0.3 mg/dl within 48 hours, an increase in scr to at least 2 times the baseline value, known or presumed to have occurred within the prior 7 days, and a urine volume less than 0.5 ml/kg/hour for a duration of 6 hours. * patients with acute pulmonary edema caused by increased afterload and fluid redistribution to the lungs in the absence or with minimal fluid accumulation. * anticipated exposure to nephrotoxic agents (such as contrast dye) during hospitalization. * patients who exhibit anuria or are undergoing renal replacement therapy or ultrafiltration. * patients with egfr less than 30 ml/min/1.73m² at the time of screening. * expected use of intravenous inotropes, vasopressors, or nitroprusside during the study. * prior cardiac transplantation and/or utilization of a ventricular assist device. * blood pressure below 90 mmhg or mean arterial pressure below 65 mmhg at the time of recruitment. * patients who are pregnant or breastfeeding. * administration of acetazolamide or metolazone within the one-month period preceding randomization. * the usage of any diuretic agent during the treatment phase is not specified in the study protocol, except for mineralocorticoid receptor antagonists.

Keywords: adhf acute decompensated heart failure ahf acute heart failure volume overload edema loop diuretics fusrosemide metolazone acetazolamide carbonic anhydrase inhibitor thiazide like diuretics thiazide diuretics
postoperative analgesia after caesarean section under alr: tap block versus catheter scar infiltration

Conditions: Scheduled Caesarian Section

Summary: the purpose of the multimodal postoperative analgesia is to improve the quality of analgesia and reduce side effects of morphine (nausea, vomiting, sedation, urinary retention, respiratory depression ...). in the case of caesarean sections, the quality of analgesia allows one hand to improve the mother-child relationship and the quality of breastfeeding, the other to reduce the risk of postpartum depression and chronic pain . two methods of administration of local anesthetics have been proven effective for analgesia of the abdominal wall under umbilical: the transversus abdominal block plan (tap block) and infiltration of the scar continues operating. the tap block was performed under ultrasound guidance by the anesthesiologist after the intervention in a single injection of local anesthetic in the abdominal wall and has a period of limited and variable. the infiltration continues catheter is placed by the surgeon before closing the wound and allows the infusion of local anesthetics for 48 hours. the purpose of this study was to compare morphine consumption between both techniques, and the quality of analgesia and side effects of morphine


Eligibility criteria:
inclusion criteria: * woman whose age is 18 years * encircled woman requiring a scheduled(programmed) caesarian, under spinal anesthesia or died combined(organized) spinal anesthesia * woman asa i and ii * term = 37 limited companies * woman primipare or not * woman having signed an informed consent writes and making a commitment to respect the instructions of the protocol exclusion criteria: * minor woman * woman presenting a contraindication to the anesthesia périmédullaire: constitutional or acquired disorders(confusions) of the haemostasis, the allergy in the local anesthetics, the infectious context (hypertherm \> 38.5 ° c) * woman presenting an intolerance or an allergy known about the morphine in the paracetamol or in ain * the surgical histories of laparotomy * the morbid obesity bmi \> 35 * dysgravidies * woman not being affiliated to the national insurance scheme * woman under legal protection * woman not having signed an informed consent
portion size strategies for management of body weight

Conditions: Obesity

Summary: the primary aim of this research is to determine the efficacy of two portion-control strategies to achieve sustainable dietary and behavior changes and to promote weight loss and maintenance. a randomized controlled trial will test two approaches to managing portion sizes: one that gives individuals skills and tools to help them make appropriate portion choices, and another that focuses on consumption of pre-portioned foods in order to limit exposure to large portions in the personal food environment. a third group will receive a basic nutritional program to promote weight loss. the second aim of the research is to determine the effects of the programs on knowledge and consumption of appropriate portions, as assessed by innovative assessment methods and multiple-pass dietary recalls. the third aim is to conduct exploratory analyses of individual factors that may influence the response to the portion-control interventions, such as psychosocial indicators, blood biomarkers, and measures of adherence to the interventions. the expected outcome of the project is that it will lead to the development of specific, evidence-based strategies to help control portion sizes in order to manage weight.


Eligibility criteria:
inclusion criteria: * body mass index of 28 to 45 kg/m squared * able to safely engage in physical activity (walking) * able to attend regular instructional sessions at university park, pennsylvania exclusion criteria: * have a medical condition diagnosed by a physician that precludes participation * report symptoms indicative of depression or disordered eating * report serious food allergies or intolerance * current or planned participation in a weight-loss program * pregnant or lactating or planning to become pregnant in the next 18 months
relationship of point-of-care coagulation assays with clinical outcomes in cardiac surgery: a retrospective cohort study

Conditions: Cardiac Surgery Requiring Cardiopulmonary Bypass

Summary: the goal of this observational study is to determine the relationship of rotem point-of-care coagulation assay parameters with excessive bleeding and clinical outcomes in patients undergoing cardiac surgery at toronto general hospital. the main questions it aims to answer are: i) how well does viscoelastic testing (vet) predict the clinical outcome of excessive bleeding in cardiac surgery? ii) which vet parameters have the greatest accuracy for identification of patients who will have excessive bleeding? iii) 3) what is the prognostic value of abnormal vet parameters with other clinical outcomes after cardiac surgery?


Eligibility criteria:
inclusion criteria: * adult patients ≥ 18 years old * underwent a cardiac surgical procedure with cardiopulmonary bypass exclusion criteria: - did not undergo viscoelastic testing during surgery

Keywords: cardiac surgery viscoelastic testing point-of-care rotem cardiopulmonary bypass bleeding