Kornimate/medical-research-clean huggingface dataset:
yoga for treatment of hot flashes

Conditions: Menopause-related Hot Flashes

Summary: the yoga for treatment of hot flashes and menopausal symptoms is an uncontrolled pilot clinical trial to determine the feasibility of recruitment and of evaluating yoga for the relief of menopausal hot flashes in 12 peri- or postmenopausal women. participants will attend an introductory yoga workshop, 8 yoga training sessions in 8 weeks, be assessed clinically before, during, and after training and contacted by telephone 3 months later.

this is an uncontrolled pilot trial of yoga among 12 healthy peri- or postmenopausal women experiencing at least 4 hot flashes per day or 30 hot flashes per week. participants will complete a screening and baseline visit, and then be taught yoga during weekly sessions that will be held in the evening at the laurel heights conference center. the yoga postures and breathing techniques will be taught by a qualified and certified yoga instructor using the standardized protocol determined by a yoga expert panel. each group yoga session will take approximately 90 minutes. participants will also be required to practice yoga at home at least 3 times per week, and be given yoga materials (mat, blocks, straps), and an instruction manual for their use at home. they will be asked to keep a calendar log of the dates/times that they practiced yoga at home. outcomes will be assessed midway through the yoga training and at a final visit. the main efficacy outcomes are change in number of hot flashes per week and change in severity of hot flashes from baseline to post-training reported on a 7-day diary. we will also measure changes in sleep and quality of life.

Eligibility criteria:
inclusion criteria: 1. self-report ≥4 moderate to severe hot flashes per day or ≥ 30 moderate to severe hot flashes per week. 2. successful completion of a hot flash diary. 3. able and willing to attend yoga training sessions, maintain yoga logs, and practice yoga at home. exclusion criteria: 1. inability to sign an informed consent or fill out questionnaires. 2. use of other treatments for hot flashes (estrogens, progestins, clonidine, selective serotonin reuptake inhibitors,relaxation techniques or acupuncture) within 4 weeks of enrollment in the trial and do not agree to refrain from using these therapies for the duration of the trial. 3. use of raloxifene or tamoxifen within three months of enrollment. 4. any condition that, in the investigator's opinion, would preclude the participant from being able to understand and follow the yoga training or from completing the trial, including severe illness, plans to move, substance abuse, significant psychiatric problems, or dementia. -

Keywords: menopausal symptoms hot flashes yoga
effects of acute dietary changes on estimates of body composition

Conditions: Overweight

Summary: the present study sought to investigate the effects of acute dietary changes on estimates of body composition. specifically, the impact of an acute high-carbohydrate diet (9 g/kg body weight of carbohydrate) and an acute very low-carbohydrate diet (1 - 1.5 g/kg body weight of carbohydrate) were examined.


Eligibility criteria:
inclusion criteria: * generally healthy * recreationally active (\>150 min/week of moderate or vigorous physical activity) * pre-menopausal with regularly occurring menstrual cycles over past 6 months (in females only) exclusion criteria: * failure to meet inclusion criteria * commencement or cessation of taking the dietary supplement creatine within the past month * pregnant or may become pregnant during the study * known or suspected food allergy to any items used in study * presence of medical condition that could reasonably be negatively affected by participation

Keywords: body composition
high-frequency ultrasound for intraoperative lymph node assessment in gynecological cancer: from surgery to radiomics

Conditions: Gynecologic Cancer

Summary: lymph node assessment is crucial in gynecological cancers (ovarian, endometrial, cervical, and vulvar), as nodal involvement significantly impacts prognosis and treatment. despite high morbidity, systematic lymphadenectomy has been widely used for staging and treatment planning. however, in most cases, lymph nodes are free from metastasis, making the procedure unnecessary and exposing patients to severe complications such as lymphedema and infections. sentinel lymph node (sln) evaluation has emerged as a less invasive alternative, reducing unnecessary lymphadenectomies. however, sln techniques face challenges, including detection failures, inaccurate frozen section analysis, and imaging limitations like false negatives in fdg pet/ct scans. the need for improved intraoperative imaging techniques is emphasized to enhance lymph node assessment, minimize surgical risks, and better tailor treatment approaches.


Eligibility criteria:
inclusion criteria: * women undergoing surgery for gynecological malignancies (ovarian, endometrial, cervical, and vulvar cancer) * need for nodal excision (staging or cytoreductive reasons) * 18-99 years old * absence of contemporary lymphatic diseases * absence of previous oncological disease in the last 5 years * willingness to participate in the study and to provide informed consent exclusion criteria: * previous radiotherapy treatments * previous chemotherapy treatments

Keywords: ovarian cancer endometrial cancer cervical cancer vulvar cancer hfus
second young adult naturalistic alcohol study

Conditions: Young Adult Alcohol Drinking

Summary: this study involves completion of questionnaires, computer-based cognitive tasks and an alcohol drinking session. participation in this study consists of an initial, in-person screening appointment, 4 brief daily appointments at the research office, an alcohol drinking session at a local bar and a follow-up appointment 1-3 days after the alcohol drinking session. participants who are found to be eligible in the screening phase will then complete a daily appointment for 4 days out of a 5-day period (i.e., there will be 1 day out of the 5 on which they will not attend an appointment). each appointment will last 20 minutes, on average and consist of a questionnaire and computer-based cognitive task. on the day of the fourth appointment, participants will complete an alcohol drinking session. the alcohol drinking session begins at 4pm and lasts until at least midnight. participants in this study will be young adults between the ages of 21-25, who regularly drink alcohol and are not currently seeking treatment for alcohol use. seventy-two participants will complete this study.


Eligibility criteria:
inclusion criteria: * be between the ages of 21-25. * be able to read english and complete study evaluations. * drink alcohol on a regular basis exclusion criteria: no participant may: * be seeking treatment for alcohol or other addictive behaviors or have been in inpatient or intensive outpatient treatment within the past 12 months. * provide two positive breath alcohol concentration (bac) readings (i.e., \> 0.00%) at any of the following times: in-person screening, a pre-session screening, or at the outset of an alcohol self-administration session. after participants blow their first positive bac, they will be allowed to reschedule and participate at another time, however if they blow a second positive bac, they will be excluded from this study and offered referrals for alcohol treatment. * have positive urine screen results at the in-person screening or pre-session screening on the day of an alcohol self-administration session for opiates, cocaine, phencyclidine, amphetamines, methamphetamine, barbiturates, methadone or benzodiazepines. * a woman who is pregnant, nursing, or refuses to use a reliable method of birth control. * fail to perform at a normative level at screening on any of the four cognitive and psychomotor tasks administered in this study. participants must perform within two standard deviations of the mean from the samples in relevant prior studies * perform computer tasks initially administered at baseline in either a random or inordinately slow fashion * a body mass index lower than 18.5 or greater than 35.
prospective, multicenter trial to investigate the safety and efficacy of percutaneous tibial nerve stimulation for the treatment of fecal incontinence

Conditions: Fecal Incontinence

Summary: the purpose of this study is to determine the effectiveness of percutaneous tibial nerve stimulation (ptns) therapy with the urgent® pc neuromodulation system (uroplasty, inc., minnetonka, mn, usa) for the treatment of fecal incontinence (fi).

pilot study

Eligibility criteria:
inclusion criteria: * patient history of chronic fi of more than staining for at least 6 months; staining defined as less than the size of a 25¢ piece (quarter) * patient reported and/or failed ≥ 2 conservative therapies (e.g., diet/fiber modification, anti-diarrheal medication, pelvic floor muscle training, biofeedback, medical management, etc.) exclusion criteria: * pregnancy or intention to become pregnant during the course of the study * implanted electro-medical device (i.e., pacemaker, defibrillator, deep brain stimulator, etc.) * clinically significant neurological diseases or nerve damage impacting tibial nerve or pelvic floor function * prone to excessive bleeding or bleeding diathesis

Keywords: fecal incontinence bowel incontinence
comparative effectiveness of metabolic and bariatric surgery with proms

Conditions: Bariatric Surgery; Metabolic Surgery; Weight Reduction

Summary: this long-term, nationwide observational data collection repository will obtain patient-reported outcomes from metabolic and bariatric surgery patients. the data will be used in conjunction with clinical outcomes to determine quality, safety, and comparative effectiveness of various metabolic and bariatric procedures.


Eligibility criteria:
inclusion criteria all preoperative metabolic and bariatric surgery patients with a scheduled metabolic and bariatric surgery at a participating center are eligible for inclusion. postoperative metabolic and bariatric surgery patients must have had their surgery within the preceding year at a participating center. exclusion criteria metabolic and bariatric surgery patients without an already scheduled surgery date at a participating center. postoperative metabolic and bariatric surgery patients who are more than 1 year postop from a participating center.
study of enahnced external counterpulsation to treat coronary heart disease

Conditions: Coronary Artery Disease

Summary: to investigate the mid- and long-term effect of enhanced external counterpulsation combined with guideline-driven standard treatment on patients documented with and/or at high risk of coronary artery disease.


Eligibility criteria:
inclusion criteria: * at least one coronary lesion of more than 50% stenosis shown by angiography * history of acute myocardial infarction(at least one month before) * history of prior revascularization (percutaneous coronary intervention or coronary artery bypass grafting) * typical angina episodes with evidence of myocardial ischemia * signed informed consent exclusion criteria: * obvious aortic insufficiency, aortic aneurysm, aortic dissection * coronary fistula or severe coronary aneurysm * symptomatic congestive heart failure * valvular heart disease, congenital heart diseases, cardiomyopathies * cerebral hemorrhage within six months, bleeding disorders or identified bleeding tendency; * lower limb infection, phlebitis, varicosity, deep venous thrombosis; * progressive malignancies or diseases with poor prognosis; * uncontrolled hypertension, defined as sbp≥180mmhg or dbp≥110mmhg

Keywords: coronary artery disease enhanced external counterpulsation
prono position and mechanical power

Conditions: Acute Respiratory Distress Syndrome

Summary: the primary objective of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning while mantaining the same ventilatory setting. the secondary objetive of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning and adjusting an individualized ventilatory setting.

data of mechanical power will be collected prospectively in three different times: 1. in supine positioning (t0). 2. after 15 minutes of having implemented prone positioning while maintaining the same ventilatory settings that in supine (t1). 3. in prone positioning after 15 min of having adjusted an individualized ventilatory setting (t2). besides, the investigators will take an arterial blood sample in t0 and t2 to calculate changes in oxygenation status and ventilatory ratio. in case that esophageal manometry is available, the investigators will collect data regarding to transpulmonary and esophageal pressure in order to calculate the mechanical power applied to the lung parenchyma.

Eligibility criteria:
inclusion criteria: * patients aged older than 18 years old under invasive mechanical ventilation with diagnostic criteria of acute respiratory distress syndrome acording to berlin definition and neccesity of prone positioning. exclusion criteria: * need to interrump prone positioning maneuver. * inability to collect data for any reason.

Keywords: ventilation, artificial respiratory distress syndrome, adult prone position monitoring, physiologic
improving care for primary care patients with diabetes and poor literacy and numeracy skills

Conditions: Type 2 Diabetes

Summary: the aim of this research will be to perform a small randomized controlled trial (rct) of a new diabetes educational intervention that teaches self-management skills that compensate for poor numeracy skills among a sample of primary care patients with type 2 diabetes and low literacy and/or numeracy.

results of the national adult literacy survey (nals) suggest that over 90 million adult americans have poor quantitative skills. numeracy, the ability to understand and use numbers and math skills in daily life, may be particularly important to patients with diabetes because caring for diabetes often requires self-management skills that rely on the daily application of math skills, such as counting carbohydrates, interpreting blood glucose monitoring, applying sliding scale insulin regimens, and calculating insulin to carbohydrate ratios. presumably diabetes patients with poor numeracy have more difficulty with self-management and are at risk for poorer clinical outcomes, but to date, there are no published studies that rigorously examine the role of numeracy in diabetes. we have recently completed the initial development of a new scale to measure numeracy in patients with diabetes: the diabetes numeracy test (dnt). the aim of this research will be to perform a small randomized controlled trial (rct) of a new diabetes educational intervention that teaches self-management skills that compensate for poor literacy and numeracy skills among a sample of patients with type 2 diabetes and low numeracy or literacy skills. we hypothesize that a group of patients with poor literacy and/or numeracy who are taught self-management skills that accommodate their poor numeracy will have: (1) improved treatment satisfaction and perceived self-efficacy, (2) improved performance in self-management tasks, and (3) improved glycemic control compared to a control group that receives usual education and care.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of type 2 diabetes 2. most recent a1c \>= 7.5% 3. referred to the diabetes care program for diabetes care 4. age 18-85; 5. english speaking. exclusion criteria: 1. patients with corrected visual acuity \>20/50 using a rosenbaum pocket vision screener 2. patients with a diagnosis of significant dementia, psychosis, or blindness.

Keywords: type 2 diabetes diabetes education health literacy
applied the platelet rich fibrin in chronic periodontitis

Conditions: Chronic Periodontitis

Summary: platelet rich fibrin is a second generation platelet concentration which contains various growth factors. the aim of this study is to evaluate the clinical and biochemical efficacy of prf in subjects of chronic periodontitis in the operation of conventional periodontal flap.

prf was developed in 2001 by choukroun in france, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. many studies have shown beneficial effects of prf on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. also prf contains many growth factors. prf accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. in this study, the investigators evaluated the effect of prf on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.

Eligibility criteria:
inclusion criteria: * patients with cp who had pocket depth ≤ 5 mm and at least two area (grouped as control and prf) with horizontal bone loss after phase i therapy exclusion criteria: * the subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months
the effect of pinnothin on satiety and food intake

Conditions: Obesity

Summary: based upon an increased secretion of gastrointestinal satiety hormones (cck, glp-1), pinnothin is hypothesized to be more satiating, and to limit energy intake in humans. therefore, the objective of this study is to investigate whether pinnothin leads to an increase in satiety as determined by vas ratings? additionally, does pinnothin consumed during breakfast, in comparison to placebo, in overweight women, lead to a decrease in energy intake during an ad libitum lunch?


Eligibility criteria:
inclusion criteria: * age over 18 and under 45 * women * bmi over 23 and under 30 * breakfast eaters exclusion criteria: * men * age under 18 and over 45 * bmi under 23 and over 30 * use of medication * pregnant and breastfeeding
outcome study of double bare stent for malignant gastric outlet obstruction

Conditions: Gastric Outlet Obstruction Due to Malignancy

Summary: self-expandable metallic stents provide effective palliation of malignant gastric outlet obstruction. however, uncovered stent are often associated with re-stenosis caused by tumor in-growth through the stent mesh. the self-expandable metallic stents which has the design of smaller wire mesh size (double bare stent) were developed and used in korea. this new design was developed to minimize the re-stenosis of uncovered stent, but the outcome is unknown. the end point of this study is the 8-weeks patency rate after placement of double bare as well as technical and clinical success rates.


Eligibility criteria:
inclusion criteria: * malignant gastric outlet obstruction * symptoms compatible with gastric outlet obstruction * an inoperable condition because of extent of disease or patient's conditions exclusion criteria: * history of enteral stent placement, undergone gastric surgery. * additional small bowel stenosis distal to gastric outlet obstruction. * refuse to be enrolled to study.

Keywords: stent gastric outlet obstruction restenosis
male partner-assisted contact tracing for hiv and tuberculosis in malawi

Conditions: Tuberculosis

Summary: the overall aim of the mpatch-tb study is to identify potentially cost-effective, feasible and scalable interventions that could increase rates of completion of screening for tuberculosis and hiv among male partners of women attending primary health care in blantyre, malawi. eligible women who consent to participate - and who have a primary male partner with cough at home -will be randomly allocated, by day of clinic attendance, into a standard of care group or one of up to four intervention groups. they will be asked to identify their primary male partner and will be offered interventions according to their allocated group. the primary outcome will compare the proportion of primary male partner that complete tb screening (defined as receipt of result of a sputum xpert or smear result) within 14 days of recruitment in each intervention group compared to the enhanced standard of care group.


Eligibility criteria:
inclusion criteria for female participants * female * attends study health centre with an acute care episode * 18 years of age or older on the day of clinic attendance * has a primary male partner living within their household * reports that primary male partner has symptoms of pulmonary tuberculosis (cough) * is resident within urban blantyre inclusion criteria for male partner participants * male * aged 18 years of age or older on the day of clinic attendance * has cough * is living with the female participant (defined as sleeping in the same dwelling on most nights during the previous 14 days) exclusion criteria for primary male partner participants in trial (applied on the same day the female participant is recruited) * currently taking treatment for tuberculosis * has taken any treatment for tuberculosis in the 6-months prior to the female participant's clinic attendance * is taking isoniazid preventive therapy * plans to move out of blantyre to live elsewhere in the following 2-months

Keywords: tuberculosis
a study of mil62 in treatment of cd20 positive b-cell lymphomas

Conditions: CD20-positive B Cell Non-Hodgkin Lymphoma

Summary: this open-label, multicenter,dose-escalating phase i study was designed to evaluate the safety, tolerability, pharmacokinetics and efficacy of mil62 in chinese patients with relapsed/refractory cd20-positive b-cell non-hodgkin lymphoma(nhl) for whom no treatment of higher priority was available.


Eligibility criteria:
inclusion criteria: 1. adult patients, \>=18 years of age; 2. diagnosis of refractory/relapsed cd20+ b-cell lymphoma or b-cll 3. eastern cooperative oncology group (ecog) performance status of 0 or 1 4. life expectancy \>6 months 5. females of childbearing potential (fcbp) must agree to use two reliable forms of contraception simultaneously or to practice complete abstinence from heterosexual contact during the following time periods related to this study: 1) for at least 28 days before starting study drug; 2) while participating in the study; 3) dose interruptions; and 4) for at least 2 months after discontinuation of all study treatments 6. able and willing to provide written informed consent and to comply with the study protocol exclusion criteria: 1. prior use of any investigational antibody therapy within 3 months of study start 2. prior use of any anti-cancer vaccine 3. prior administration of radioimmunotherapy 3 months prior to study entry 4. central nervous system lymphoma 5. history of other malignancy 6. evidence of significant, uncontrolled concomitant disease 7. abnormal laboratory values 8. patients with progressive multifocalleukoencephalopathy (pml) 9. infection with human immunodeficiency virus (hiv), hepatitis b or hepatitis c(including hbsag,hbcab positive with abnormal hbv dan or hcv rna ) 10. known severe allergic reaction or/and infusion reaction to monoclonal antibody.