Kornimate/medical-research-clean huggingface dataset:
toronto bnb pilot study

Conditions: Brain Metastases

Summary: as treatments improve and patients live longer with cancer, even after it has spread to the brain, efforts to improve quality of life are growing. neurocognitive function (thinking ability and memory) is an area of particular concern for patients with brain metastases (cancer that can spread to the brain). although there are established tests to measure neurocognitive function, these require a face-to-face assessment and can take a long time to complete. as a result, efforts to use these tests to measure changes in neurocognitive function in patients following treatment for brain metastases have resulted in a large proportion of patients who do not return for follow-up. this has limited the ability to evaluate the impact of current treatments on neurocognitive function. this study aims to evaluate a shorter, telephone-based neurocognitive assessment tool, which would make it easier for patients to complete these tests in follow-up. if this new tool is found to reliably measure neurocognitive function, it could be used for future studies evaluating new interventions that prevent or treat neurocognitive deterioration following treatment of brain metastases. this is the first prospective study to evaluate the feasibility and reliability of a novel telephone-based brief neurocognitive assessment battery (toronto bnb) compared with the same battery delivered face-to-face in this population. the investigators hypothesize that telephone administration of this brief neurocognitive battery will reliably evaluate neurocognitive function and improve patient ability to complete follow-up assessments.


Eligibility criteria:
inclusion criteria: * adult (\> 18 years old) with newly diagnosed brain metastases planned for whole brain radiotherapy * performance status ecog 0-2 * english-speaking (due to small sample-size in this pilot study, only english testing will be completed) exclusion criteria: * prior whole brain radiotherapy * presence of any condition which can prevent completion of neurocognitive assessment, including: * hearing impairment which is sufficient to prevent the patient from comprehending english instructions in a quiet environment * major psychiatric diagnosis or neurological condition associated with cognitive impairment which, in the judgement of the investigator, would make the patient inappropriate for study participation (e.g., schizophrenia, multiple sclerosis, parkinson's disease, prior ischemic stroke, dementia, traumatic brain injury with loss of consciousness for greater than 30 minutes, expressive/receptive aphasia, developmental delay) * patients with planned systemic therapy or additional radiotherapy within the interval between clinic and telephone toronto bnb testing * minimal english skills such that subjects would be unable to follow simple english instructions (either verbal or written) or be unable to read questionnaires of a grade 8 standard with the help of a research assistant.

Keywords: brain metastases brain mets wbrt
prosthesis guided speech rehabilitation of t1/t2 cancers of the tongue

Conditions: Tongue Neoplasms; Tongue Cancer; Oral Cancer

Summary: this study will fill a scientific gap in the current knowledge providing data for evaluation of the palatal augmentation prosthesis (pap) as a therapeutic modality post-surgery. this is a robust scientific randomized prospective clinical trial. positive outcomes from this study have the potential to dramatically alter the most common issues of oral cancer therapy, namely speech and swallowing functions. patients will have been diagnosed with a cancer lesion of the tongue requiring surgery and removal of part of the tongue. smaller cancers of the tongue are sized as t1 or t2. for patients with smaller lesions, a pap, which can aid in speaking and swallowing, is not routinely provided.

this study will randomize patients into two arms; one for oral cancer patients that receive a small device, similar to a denture, called a pap. the other arm will be patients who serve as a control and will not receive a pap. the pap requires patients to have a dental mold created. a dentist customizes the pap to specifically fit the individual's mouth. the study will investigate whether the pap improves speech following tongue cancer as measured by three different scales. both groups will see a speech language therapist for additional measures of speech evaluation.

Eligibility criteria:
inclusion criteria: * patients with a new diagnosis of a t1/t2 tongue cancer exclusion criteria: * patients with recurrent disease * patients with a history of prior head and neck radiation therapy * patients who lack adequate maxillary dentition to support a palatal augmentation prosthesis

Keywords: palatal drop prosthesis
platelet rich plasma in treatment of melasma

Conditions: Melasma; Platelet Rich Plasma

Summary: melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. the therapy for melasma has always been challenging and discouraging. platelet rich plasma has been used over the last several years as an effective treatment in various surgical and medical ﬁelds. in recent years, platelet rich plasma has also started to be used in the field of cosmetology. this study is designed to evaluate the therapeutic effect of platelet rich plasma in melasma.

melasma is a pigmentary disorder that can be disfiguring and can cause to significant emotional stresses for sufferers, for which a universally effective treatment is still lacking. platelet rich plasma is commonly used in dermatology and plastic surgery, especially for treating chronic wounds, ulcers, and burns. the most important contents of platelets are contained in the α-granules. some of the bioactive substances present in the α-granules include platelet-derived growth factor, transforming growth factor -β1 and -β2epidermal growth factor, and mitogenic growth factors such as platelet-derived angiogenesis factor and fibrinogen. transforming growth factor -β1 decreases melanogenesis via delayed extracellular signal-regulated kinase activation. the regression of melasma in a 27-years-old woman after injecting platelet rich plasma for skin rejuvenation was observed, but controlled clinical trials are still lacking to confirm this preliminary observation.

Eligibility criteria:
inclusion criteria: * patients with melasma 18 years old or more exclusion criteria: * patients less than 18 years. * pregnant females and females on oral contraceptive pills. * patients with a history of hypertrophic scars or keloids. * patients with recurrent herpes infection or with present cutaneous infection and those with facial cancer. * patients with blood disorders and platelet abnormalities and chronic liver disease. * patients using systemic chemotherapy, anticoagulation therapy and antiplatelet agents.
advanced radiotherapy (art) in gynecological cancer patients (gyn-art)

Conditions: Gynecologic Cancer; Radiotherapy Side Effect; Radiotherapy; Complications; Survivorship; Progression, Disease; Progression, Clinical

Summary: this is an observational mono-institutional study. patients with gynecologic tumors treated with advanced radiotherapy- image guided radiotherapy (igrt), intensity modulated radiotherapy (imrt), stereotactic body radiotherapy (sbrt)- will be included and toxicity and outcomes analyzed.

the patients with gynecological cancer treated with advanced radiotherapy (art)- image guided radiotherapy (igrt), intensity modulated radiotherapy (imrt), stereotactic body radiotherapy (sbrt)- at the department of radiotherapy of "irccs san raffaele scientific institute" (irccssraffaele) from january 2005 to january 2024 will be identified and their clinical and dosimetric data retrieved and analyzed. the study objectives are the analysis of acute and late toxicity, and clinical outcomes, such as local, regional and distant control,disease free survival, cancer-specific survival, and overall survival. secondary objective is the identification of prognostic factors for toxicity, disease progression, survival, including radiomic characteristics.

Eligibility criteria:
inclusion criteria: * gynecologic cancer patients * \>18 years old * treated with advanced radiotherapy techniques (igrt, imrt, sbrt) exclusion criteria: * other tumors * \> 90 years old

Keywords: gynecologic cancer image guided radiotherapy pet/ct intensity modulated radiotherapy stereotactic body radiotherapy oligometastases
recanalization of congenital nasolacrimal duct obstruction by endodiathermy probe and intubation versus intubation only

Conditions: Congenital Nasolacrimal Duct Obstruction

Summary: the purpose of the current work is to assess the efficiency and success rate of endodiathermy probe followed by intubation in children more than 2 years compared to the success rate of intubation (as a standard method) which varies from 75% to 85% in several studies

the study will be conducted on children above 2 year and will be divided randomly into two groups: group (i): 80 eyes of children suffer from congenital nasolacrimal duct obstruction will have probing with metal probe and then intubation with bicanlicular silicon tube. group (ii): 80 eyes of children suffer from congenital nasolacrimal duct obstruction will have probing with endodiathermy probe and then intubation with bicanlicular silicon tube

Eligibility criteria:
inclusion criteria: 1. children in the age group above 2 years old 2. no history of previous probing. 3. no history of previous intubation. 4. children with no any other association or congenital anomalies cause watery eye. 5. children suffer from congenital nasolacrimal duct obstruction. exclusion criteria: 1. children less than 2 years old. 2. previous probing. 3. previous intubation. 4. children with any other congenital anomalies as congenital ectropion , congenital entropion 5. children suffer from any upper lacrimal anomalies as obstruction or stenosis.

Keywords: endodiathermy probe and intubation versus intubation only
transcutaneous electrical nerve stimulation during exercise in patients with copd

Conditions: COPD; Physical Activity; Rehabilitation; TEN

Summary: early pulmonary rehabilitation is recommended after an episode of severe exacerbation of chronic obstructive pulmonary disease (copd). however, its implementation is challenging particularly as regard exercise training. several studies showed that transcutaneous electrical nerve stimulation (tens) could improve dyspnea and pulmonary function. the aim of this study is to assess the acute effect of tens on exercise tolerance in post-exacerbation copd patients


Eligibility criteria:
inclusion criteria: * a diagnosis of copd exclusion criteria: * exercise contraindication any musculoskeletal problems, cardiovascular or * neurological comorbidities that limits exercise. * ph \< 7,35 * body temperature \> 38°c * cardiac frequency \> 100 bpm at rest * systolic blood pressure \< 100 mmhg * exacerbation during the study * heart pace-maker or defibrillator * opiate treatment during the last 3 months
micropulse diode laser treatment for chronic central serous chorioretinopathy

Conditions: Central Serous Chorioretinopathy

Summary: the aim of this study was to evaluate safety and therapeutic response to micropulse diode 810nm laser treatment in patients with chronic central serous chorioretinopathy.

most of the cases of central serous chorioretinopathy (csc) recur spontaneously within three months of disease. after 3 months without resolution of acute csc or in chronic csc, continuous wave laser photocoagulation or photodynamic therapy should be considered. direct threshold continuous photocoagulation treatment can shorten the duration of the serous detachment, but it is not appropriate for juxtafoveal or subfoveal leakage point.subvisible photocoagulation potentially localizes and decreases chorioretinal thermic burn. subthreshold diode micropulse (sdm) laser using a 810nm diode laser may spare the damage to the neural retina by raising the temperature of the rpe to just below the protein-denaturation threshold so that the thermal wave that reaches the neural retina is insufficient to cause neither damage nor clinically visible end-point. this therapeutic laser modality offers the possibility to minimize the iatrogenic retinal lesion.

Eligibility criteria:
inclusion criteria: * chronic active central serous chorioretinopathy lasting more than 6 months * leakage at fluorescein angiogram exclusion criteria: * opacities of the clear refractive media of the eye * any intraocular surgery within the 6 months prior to study entry * prior vitrectomy
open reduction in femoral neck fractures

Conditions: Femoral Neck Fractures

Summary: outcomes of open reduction and internal fixation of femoral neck fractures using dynamic hip screw versus cannulated screws combined with medial buttress plate.

-femoral neck fractures (fnfs) in patients under the age of 50 years account for less than 5% of all hip fractures and are typically the result of a high-energy event. fnfs in young patients, particularly displaced fractures, are challenging to treat. internal fixation remains the consensus, and the quality of the reduction is more important than the time to surgery. femoral head necrosis and fracture nonunion have always been the two major complications of femoral neck fracture treatment, which greatly increases the difficulty of treatment and places a high burden on social and medical resources. as previous studies have demonstrated, reoperation rate for a failure of internal fixation ranges from 10% to 48.8% and has remained largely unchanged over the past 30 years. there are many options to treat femoral neck fracture. previous studies reported that femoral neck fractures with following surgery are associated implant failure. currently, the most common types of fixation include cannulated screws, hip screw systems, proximal femur plates, and cephalomedullary nails. \[7\] arthroplasty may be an option for elderly patients, but is generally not feasible for young patients; young patients with fnf require a more durable and promising fixation. however, there is no consensus on the best fixation method for fnf in young patients. cs has better biomedical properties such as anti-rotation and less invasive, which was widely used in non-displaced intracapsular fractures. dhs could maintain the neck-shaft angle and anatomical reduction, which is helpful for fracture fixation. a medial buttress plate can clamp the fracture apex, neutralize shearing forces, and transfer them into compressive forces into the plane of cannulated screws or other typical construct. thus far, there has been no optimal internal fixation method.

Eligibility criteria:
inclusion criteria: * patients of both genders between the ages of 16 to 60 years old and had trauma caused femoral neck fracture. * patients of both genders with garden's type three and four femoral neck fractures exclusion criteria: * patients of both genders below the age of 16 and above 60 years old. * patients with pathological femoral neck fractures. * patients with autoimmune diseases like rheumatoid arthritis. * patients with neglected femoral neck fractures(more than 1 week).

Keywords: open reduction
observational study of the incidence of pressure ulcers on the help support of prevention of bedsores polyair®

Conditions: Pressure Ulcer

Summary: the support of help to the prevention of sores include a big diversity of devices. the clinical experiment of these support comes up against the problem of the large number of factors participants in the genesis of bedsores. nevertheless, it seems to be interesting to estimate the incidence of bedsores in these supports, with control of other factors


Eligibility criteria:
inclusion criteria: * norton index \<9, * no sores in ischiatic zone, * sitting position not less than 2 hours per day exclusion criteria: * sores in ischiatic zone, * sitting position \>2 hours per day
measuring beliefs and norms about persons with mental illness

Conditions: Mental Illness; Schizophrenia; Bipolar Disorder; Depression

Summary: survey experiment to estimate drivers of mental illness stigma

despite significant advances in scientific understanding of brain and substance use disorders accompanied by significant advances in treatment and improvements in prognosis, mental illness remains highly stigmatized throughout the world. previous studies suggest that portraying mental illness as treatable can reduce negative attitudes toward persons with mental illness. this randomized controlled trial compares the effects of exposing study participants to vignettes portraying persons with untreated and symptomatic mental illness vs. treated mental illness with complete response vs. treated mental illness with relapse. it is hypothesized, based on prior work, that study participants exposed to vignettes depicting treated mental illness with completed response would have the greatest effect on reducing negative attitudes toward persons with mental illness, followed by treated mental illness with relapse and untreated and symptomatic mental illness.

Eligibility criteria:
inclusion criteria: * all persons who considered nyakabare parish their primary place of residence and who were capable of providing consent exclusion criteria: * minors younger than 18 years of age, with the exception of emancipated minors * persons who did not consider nyakabare their primary place of residence, e.g., persons who happened to be visiting nyakabare at the time of the survey or who owned a home in nyakabare but spent most of their time outside the parish * persons with whom research staff could not communicate, e.g., due to deafness, mutism, or aphasia * persons with psychosis, neurological damage, acute intoxication, or other cognitive impairment (all of which were determined informally in the field by non-clinical research staff in consultation with a supervisor)
ltap block in endometriosis surgery - a randomised controlled double-blind trial

Conditions: Endometriosis; Peritoneum; Postoperative Pain

Summary: the purpose of this study is to compare the efficacy and safety of laparoscopically inserted transversus abdominis plane block (ltap) in comparison to local wound analgesia in laparoscopic surgery due to suspected or diagnosed peritoneal endometriosis.

the ltap-trial is a prospective randomized controlled double-blinded study comparing the efficacy and safety of ltap with local wound analgesia in laparoscopic endometriosis surgery. patients are randomized to receive ltap with levobupivacain and wound infiltration with placebo or wound infiltration with levobupivacain and ltap with placebo. the primary outcome is postoperative opioid consumption measured by patient controlled analgesia -pump (pca). secondly, subjective postoperative pain up to 24 h postoperatively will be measured by numeric rating scale (nrs). additional outcome measures are factors related to recovery and length of stay in the hospital as well as a 6 month follow-up survey regarding pain and general wellbeing after surgery. a total of 46 patients will be randomized in a proportion of 1:1.

Eligibility criteria:
inclusion criteria: * surgery indicated because of pain caused by diagnosed or suspected peritoneal endometriosis * asa class 1-3 * patient is capable of giving informed consent exclusion criteria: * obstructive sleep apnea * asa class \>4 * other significant risks associated with opioid use * contraindications for local anesthetics or nsaids * regular opioid consumption before operation

Keywords: endometriosis postoperative pain management laparoscopic surgery gynecological surgery
primary mediastinal large b-cell lymphoma (pmbcl): multicenter retrospective study

Conditions: Primary Mediastinal Large B-cell Lymphoma (PMBCL)

Summary: the present study consists of a retrospective multicentric collection of all consecutive patients with pmbcl diagnosed over the time period considered (13 years, from 2007 to 2019 inclusive).

the study was initially set up as a spontaneous, non-profit study, with arnas garibaldi of catania (pi dr ugo consoli) as the proposer. subsequently, the project was expanded to include additional centres belonging to the italian lymphoma foundation, which became the promoter in collaboration with arnas garibaldi of catania. the information collected is aimed at verifying the application in a "real world" context of the pmbcl diagnosis and therapy protocols suggested in the guidelines and at checking whether they produce results in line with those expected. the therapies considered for the i line of treatment are those described in the literature for the pathology under consideration: * r-chop14; r-chop21 and r-chop like, (r-chop: rituximab - cyclophosphamide, doxorubicin, vincristine, prednisone) * r-vacopb, r-macopb and r-vacopb like, macopb like, (r-vacop-b: rituximab - etoposide, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin. r-macop-b: rituximab - methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) * r-da-epoch ed r-epoch like (da-r- epoch: dose adjusted - rituximab - etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin)

Eligibility criteria:
inclusion criteria: * all consecutive patients treated in the centre during the period considered * age\>=18 years * histological diagnosis of pmbcl * signature of "informed consent" to participate in the study (if applicable) * treatment according to local practice * diagnosis between 01 january 2007 and 31 december 2019 exclusion criteria: - the exclusion criteria, being an observational study, are focused and limited to excluding cases with a non-compliant histological diagnosis.
efficacy of the transversus abdominis plane block on analgesia after cephalic duodeno-pancreatectomy

Conditions: Pancreatic Neoplasms

Summary: pancreatic duodenectomy is one of the treatments offered to patients with neoplastic disease of the pancreas. in france, in 2018, 14,000 duodeno-pancreatectomies were performed, including 140 at the hautepierre hospital at the strasbourg university hospital. pancreaticoduodenectomy is a major surgery, causing significant postoperative pain that should be minimized through multimodal analgesia involving in particular locoregional anesthesia. since 2019, the recommendations of the eras company concerning eras (improved rehabilitation after surgery) after pancreaticoduodenectomy recommend the establishment of thoracic epidural analgesia in order to limit postoperative pain. when there is a contraindication to the placement of a thoracic epidural, in particular due to arterial and/or venous vascular reconstructions requiring potential perioperative curative anticoagulation, the administration of local anesthetic by pericatricial catheter is recommended. recommended. the transversus abdominis plane (tap) block has proven analgesic efficacy, safety and harmlessness in colorectal surgery.


Eligibility criteria:
inclusion criteria: * major subject (≥18 years of age) * subject operated at hus for cephalic duodeno-pancreatectomy between 01/01/2018 and 01/04/ 2022. * subject who has not expressed an objection to the reuse of their data for scientific research purposes. exclusion criteria: * subject having expressed his/her opposition to participate in the study * admission in intensive care unit after the operation * morphine treatment at home * drug addiction, weaned or not

Keywords: neoplastic disease pancreatic neoplasia pancreatic neoplasms transversus abdominis plane block tap-block cephalic duodeno-pancreatectomy
observational study of lumigan® 0.01% treatment for patients with primary open angle glaucoma or ocular hypertension

Conditions: Glaucoma, Open-Angle; Ocular Hypertension

Summary: this study will assess the efficacy, safety, tolerability and persistence of use of lumigan ® 0.01% in patients diagnosed with primary open-angle glaucoma or ocular hypertension who are treated per routine clinical practice.


Eligibility criteria:
inclusion criteria: * diagnosis of primary open-angle glaucoma or ocular hypertension * lumigan® 0.01% prescribed either as monotherapy or adjunctive to beta-blocker therapy exclusion criteria: * none