Kornimate/medical-research-clean huggingface dataset:
effect of flax, poppy, sesame & salba on postprandial blood glucose response, vascular, appetite & sensory parameters

Conditions: Cardiovascular Diseases

Summary: consumption of whole grains has been heavily endorsed by both government and major health agencies, as evidenced in health canada's food guide, the us department of agriculture's food pyramid, and the heart and stroke foundation's healthy eating guide. whole grains have been championed for their proposed cardioprotective and weight control effects as suggested by epidemiological studies. the health benefits of whole grain products may be attributable to their nutrient composition, which contains dietary fibre, protein and several essential nutrients. there has also been a concurrent increase in seed consumption. seeds have a similar and potentially superior nutritional composition to whole grains and they are rich in mammalian lignans and polyunsaturated fats, especially the highly valued omega-3 fatty acids. preliminary studies on seeds have shown that they impart health benefits similar to those imparted by whole grains. consumer choices regarding seed consumption may be based on their potential health benefits. furthermore, they may also be affected by subjective sensory factors, such as appearance, taste and pre-conceived perceptions. therefore, this study will compare the health properties of four seeds and their effects on appetite and sensory parameters in healthy individuals. these four seeds will be that of flax, poppy and sesame, due to their popularity and consumption as well as salba, which has also recently received much attention for its associated health benefits.


Eligibility criteria:
inclusion criteria: * age 18-65 years * normal glycemic response * bmi between 18.5 - 25 kg/m2 * peripheral systolic and diastolic blood pressure \< 140mmhg and \< 90mmhg exclusion criteria: * known history of liver or kidney disease, diabetes, hypertension, stroke or myocardial infarctions, thyroid disease, celiac disease/gastrointestinal disease, or aids; * allergies to any of the test products * using prescription medications or natural health products * any condition which, in the opinion of the investigator, might jeopardize the health and safety of the subject or study personnel, or adversely affect the study results
nutri-hab - posttreatment rehabilitation of nutrition impact symptoms in head and neck cancer survivors

Conditions: Head and Neck Cancer

Summary: the study is a randomised controlled trial that aims to test the effect of a residential rehabilitation program with a focus on eating problems after treatment in head and neck cancer survivors. the study will furthermore investigate whether selected nutrition screening and assessment tools can be used to identify head and neck cancer survivor who benefit from the program.

this study is a randomised controlled trial with following objectives: 1. to test the effect of a targeted residential rehabilitation program with focus on the physical, psychological and social aspects of eating problems on body weight, health-related quality of life and physical function in curatively treated head and neck cancer survivors 1-5 years after completion of radiation therapy 2. to test whether a potential effect of the program is associated with/dependent of the participants' score in scores patient-generated subjective global assessment short form (pg-sga-sf), nutrition risk screening 2002 (nrs 2002) or m.d. anderson dysphagia inventory (mdadi) at baseline

Eligibility criteria:
inclusion criteria: * cancer of the larynx, pharynx or oral cavity * treatment with radiation therapy completed 1-5 years before inclusion * curatively treated * expression of interest in participating in the rehabilitation program in a preceding survey * self-reliant and no need for assistance with personal hygiene etc. exclusion criteria: * active cancer disease at the time of recruitment * not being able to speak and understand danish * no permanent residence in denmark

Keywords: rehabilitation nutrition impact symptoms quality of life
an investigational study drug, palbociclib (pd-0332991), is being studied in patients with mantle cell lymphoma. patients must have received prior treatment(s) for mantle cell lymphoma.

Conditions: Lymphoma, Mantle-Cell

Summary: this is a pilot study evaluating tumor activity using positron emission tomography, which is also known as a "pet scan". this study will assess the safety of using pd-0332991 in patients with mantle cell lymphoma.


Eligibility criteria:
inclusion criteria: * histologically documented mcl. * must have received at least one prior therapy. * eastern cooperative oncology group (ecog) performance status ≤1. * adequate organ function as outlined in the protocol. exclusion criteria: * major surgery, radiation therapy, or systemic therapy within 4 weeks of study enrollment. * prior radiation therapy to \>25% of the bone marrow (whole pelvis is 25%). * uncontrolled brain metastases, spinal cord compression, carcinomatous meningitis, or leptomeningeal disease.
comparaison between digital and drug induced sedation in veinous access device implantation

Conditions: Oncology

Summary: the goal of this clinical trial is to compare in patients who need an implantation of a veinous access device the sedation with anesthesiologic drugs and with hypnosis using virtual reality material. the main question it aims to answer is: • is hypnosis using virtual reality as safe and powerfull than usual anesthesiologic drugs. participants will complete a preoperative and postoperative questionnaire. they will be contacted by phone pre and postoperatively. if there is a comparison group: researchers will compare drug induced sedation and hypnosis induced by virtual reality to see if they are similar in efficacy and sides effects.

this study has two arms. all patients has the same preparation to surgery. they had lorazepam 2.5 mg 30 minutes before the surgery. in operative theater, they are randomly chosen between anesthetic protocol (sufentanyl 5mg intravenous) or digital sedation (sedakit(r) ) with hypnosis induced by virtual reality. patients complete an anxiety test (hamilton scale) 2 days before the surgery and 2 days after the surgery. they are called by an external psychiatrist 1 day before the surgery and 3 days after to evaluate the anxiety link to the procedure.

Eligibility criteria:
inclusion criteria: * need for a venous device implantation exclusion criteria: * need for a general anaesthesia * unability to give oral consent * under 18 years

Keywords: central veinous catheter virtual reality induced hypnosis
obstetric outcomes after transvaginal specimen extraction in gynecological laparoscopy

Conditions: Pregnancy Complications; Delivery;Abnormal;Stillbirth

Summary: one of the most important downsides of endoscopic surgery is the need to remove surgical specimens of different sizes through very small incisions. this step should ensure the complete retrieval of the surgical specimen with concomitant preservation of its integrity (if possible) in order to avoid intraabdominal contamination of potentially infected or malignant tissues. possibilities for specimen extraction during laparoscopy include minilaparotomy, enlargement of an ancillary port, transumbilical extraction, and transvaginal extraction through posterior colpotomy. although recent evidence has already suggested that transvaginal extraction through posterior colpotomy is a safe and feasible option, to date there are no published data about obstetric outcomes after this procedure. for this reason, the current study aims to evaluate obstetric outcomes between women that underwent transvaginal specimen extraction through posterior colpotomy and women who did not.


Eligibility criteria:
inclusion criteria: * pregnancy exclusion criteria: * any pre-existent cause of high risk for adverse obstetric outcomes.

Keywords: obstetric outcomes transvaginal specimen extraction gynecological laparoscopy
lumbar manipulation for hip and muscle strength

Conditions: Patellofemoral Pain Syndrome; Anterior Knee Pain Syndrome

Summary: the aim of this double blind, randomized, placebo-controlled clinical trial is to investigate the immediate effects of spinal manipulation on hip and knee muscle strength and pain-free deep squat range of motion in order to answer several conceptual and practical research questions

this prospective, double-blind, randomized control trial clinical will use a multigroup pretest-posttest control design with 1 treatment arm and 1 control arm. interpreted within the biopsychosocial model and the international classification of functioning, disability and health (icf) framework, this research will measure the outcomes between patellofemoral pain syndrome (pfps), the health condition, and contextual factors, particularly personal factors. it will address personal factors such as gender and age but will not address environmental factors. this research includes tests and measures of two of the three levels of human functioning, or domains, impairments to body functions and structures and activity limitations. muscle strength testing is an impairment-level measure and pain-free deep squat range of morion (rom) is an activity limitation-level measure.

Eligibility criteria:
inclusion criteria: * referred to out-patient physical therapy for a knee condition and a chief complaint of anterior knee pain * anterior knee pain with squatting * agreed to be in the study and signed the informed consent document exclusion criteria: * presence of any medical 'red flags' suggestive of pain that is not of musculoskeletal origin * osteoporosis or recent fracture of the hip or spinal joints * spinal or hip joint surgery or prosthesis * knee surgery on the affected knee within the last 6 months * spinal instability (grade ii spondylolithesis or greater), spondyloarthritides, or severe spinal misalignment * nervous system disease or disorder * pregnant * lumbar nerve root compression (any of the following signs present) * positive straight leg raise (slr) test less than 45° * marked paresis involving a major muscle group of the lower extremity * diminished, and asymmetric (lower than uninvolved side), lower extremity * muscle stretch reflex * diminished or absent sensation to pinprick in any lower extremity dermatome

Keywords: spine manipulation
effect of sciatic nerve slider technique in different positions in low back pain patients

Conditions: Low Back Pain; Sciatica

Summary: neural mobilization is a technique that plays an important role in repairing the neural tissue's ability to respond to stress or tension by triggering the reconstruction of normal physiological functioning, pain reduction, and functional improvement. the study aims to examine the effect of the sciatic nerve slider technique in different positions and which of the most common positions is more effective in the application of neural mobilization in low back pain with sciatica.

low back pain (lbp) is one of the most common musculoskeletal disorders, accounting for a significant portion of disability. it's a severe healthcare burden that has large societal costs, according to estimates, lbp can affect anywhere between 22% and 65% of people within a year. additionally, back pain-related absences from work result in prolonged periods of sick leave, which has an adverse effect on workplace productivity. sciatica is the name given to a collection of symptoms caused by compression and irritation of the sciatic nerve, including pain, numbness, muscular weakness, and difficulty moving or controlling the legs. the lower back, buttocks, and multiple dermatomes of the leg and foot are typically where symptoms appear. sciatica can be caused by a disc bulge or herniation, lumbar canal stenosis, spondylolisthesis, trauma, piriformis syndrome, or spinal tumors. it affects women more than men and people who lead sedentary lifestyles more than active ones. it might arise quickly or gradually with physical activity, and it is usually unilateral. the slider and tensioner are two distinct types of neural mobilization procedures. there are clinical improvements and positive therapeutic benefits after treatment with different neural mobilization techniques, but the slider technique is safer, involves less stretching and strain of the nerves, and has a more significant effect than the tensioner technique.

Eligibility criteria:
inclusion criteria: * age range between 40 - 65 years, * both genders, * diagnosed by magnetic resonance imaging to confirm disc lesion, * lbp with radicular pain for more than 12 weeks up to 1 year with no acute episodes in the last 4 weeks, and a numeric pain rating score (nprs) greater than 4/10. * positive slr test with reproduction of neurological symptoms. exclusion criteria: * sciatica due to other pathologies (e.g. lumbar canal stenosis or piriformis syndrome), * having any physiotherapy before 6 months. * history of spinal surgery * vertebral fracture or trauma, * negative slr test, * pregnant.

Keywords: low back pain neuromobilization sciatic nerve slider technique positions
the effectiveness of individual placement and support in chronic pain patients

Conditions: Chronic Pain

Summary: individual placement and support (ips) is an evidence-based approach originally developed to help people with severe mental disorders to obtain and maintain employment. the effectiveness of ips for patients with severe mental illness is well documented, but has never previously been tested for patients with chronic pain. in fact, employment support is rarely provided in pain clinics, despite an increasing focus on integrating work and health in all patient treatment (oecd, 2013). the aim of this study is to investigate the effectiveness of ips as an integrated part of the interdisciplinary treatment for patients with chronic pain in a hospital outpatient clinic.

individual placement and support (ips) is an evidence-based approach originally developed to help people with severe mental disorders to obtain and maintain employment. ips represents a relatively new approach to vocational rehabilitation and incorporates following principles: (1) every person that wants to work, can work given that the person is provided with the appropriate work and environment. (2)the goal is employment in regular, competitive employment. (3) ips is integrated with treatment. (4) job search is individualised; based on the participants' preferences and competence. (5) work incentives planning is provided; which includes counselling about how work can influence social security and other public benefits. the intention of this benefits counselling is to enable the participant to make informed decisions about work (job starts and changes). (6) the job support is not time-limited. (7) finally, ips differs from more traditional employment services in that it does not involve pre-vocational training, often referred to as "train, then place". (8) in ips job search starts as soon as the client expresses an interest in work. therefore, ips follows the principle "place, then train". the effectiveness of ips for patients with severe mental illness is well documented. international research shows that ips is more effective than other types of employment programs for this group of clients. however, the effect of ips on patients with chronic pain in an outpatient hospital clinic is largely unknown.

Eligibility criteria:
inclusion criteria: * patients referred to the pain clinic and eligible for interdisciplinary treatment * not currently working (long-term sick leave, disability pension or unemployed) * expressed desire to work exclusion criteria: * living too far away from the pain clinic (outside of oslo)
treatment of antenatal chlamydia infection

Conditions: Chlamydia Trachomatis Infection in Pregnancy

Summary: pregnant women in antenatal clinic will be screened for chlamydia trachomatis infection with endocervical swab.those that test positive and satisfy the inclusion criteria will be counselled and enrolled into the study after obtaining informed consent.the participants will be randomised into one of the two groups.the drugs will be taken for i week and the sexual partner(s) will also be treated with doxycycline for 1 week. barrier contraception will also be used during the treatment.the sexual partners will be contacted through telephone calls and the benefits of participating in the study will be explained to them. latex male condom will be given to the women. also, follow-up telephone calls will be put across to them during the treatment week to enhance compliance. a repeat endocervical swab will be taken 4 weeks after treatment to check for microbiological clearance. a study proforma will be filled during this visit. the data will be analysed using statistical package for social sciences version 17.

aim(s) of the research to assess the efficacy and tolerability of amoxicillin compared to erythromycin in treatment of antenatal chlamydia infection objectives of the research * to determine the prevalence of chlamydia trachomatis infection in pregnancy * to compare the proportion of subjects with clearance of antenatal chlamydia trachomatis infection between the erythromycin and amoxicillin groups * to compare the occurence of side effects between the two groups * to compare the drug discontinuation rates between the two group

Eligibility criteria:
inclusion criteria: 1. test positive to chlamydia rapid screening kit 2. estimated gestational age less than 36 weeks 3. consent to participate in the study 4. willingness or ability to comply with follow-up schedule exclusion criteria: 1. antenatal patients whose gestational age is more than 36 weeks 2. history of reaction to any of the drugs 3. women with low lying placenta or placenta praevia 4. history of other antibiotics intake within two weeks of recruitment
cerebral hemodynamics and microemboli during placement of relay®branch thoracic stent-graft system

Conditions: Thoracic Aortic Aneurysm; Thoracic Aortic Dissection; Microemboli

Summary: this is an observational cohort study addressing the incidence of cerebral microemboli and alterations of cerebral hemodynamic physiology of the relay®branch thoracic stent-graft system.

this study is a prospective multi-center observational study. eligible patients will be enrolled in relaybranch (nct03214601). participating centers must have capabilities of performing intra-operative tcd monitoring and post-operative tcd monitoring. if sites have performed tcd microembolic monitoring during previous relaybranch procedures, we will also incorporate these data in our analysis. the primary objective is to assess the number and timing of cerebral microemboli during relay®branch thoracic stent-graft deployment, to identify the highest risk portions of the procedure. secondary objectives include: correlate procedural microembolic burden with neuroimaging and clinical outcome; quantify post-operative microemboli, correlating with neuroimaging and clinical outcome; and quantify the changes in cerebral blood flow and cerebral autoregulation that happens during critical procedural epochs, correlating with neuroimaging and clinical outcome.

Eligibility criteria:
inclusion criteria: * enrollment in nct03214601 based on presence of a thoracic aortic aneurysm, penetrating atherosclerotic ulcer, or chronic type b dissection that would require coverage of the brachiocephalic trunk and/or left carotid if a non-branching endograft were implanted advanced heart failure with plan to treat with lvad * at least 18 years of age * patients enrolled prospectively must sign the informed consent form * if patients underwent tcd monitoring during a previous relaybranch procedure as part of routine clinical care, we will also incorporate their data in our analysis exclusion criteria: * skull defect or skull surgery that will preclude monitoring * known lack of tcd temporal acoustic window (if had tcd in past) * expected surgical position will preclude access to the patient's head for monitoring
long-term growth and skeletal effects of early growth hormone treatment in turner syndrome

Conditions: Turner Syndrome

Summary: this is an extension study that will gather long-term data on the effect of early growth hormone (gh) treatment on adult height and other aspects of health and development in girls with turner syndrome. the main purpose is to determine whether girls who received 2 years of gh treatment before 6 years of age achieve taller adult height than girls who were untreated during this time. the study will also look at middle ear and hearing function, and cognitive and behavioral development. protocol completion is defined as attainment of height velocity less than or equal to 1.0 cm/year, or bone age greater than or equal to 15 years.


Eligibility criteria:
inclusion criteria: * previously randomized in study b9r-us-gdfg (nct00406926) * karyotype-proven turner syndrome exclusion criteria: * immediate family members of study site personnel directly affiliated with the study
evaluating the impact of reining in anxiety

Conditions: Anxiety; Anxiety Disorder

Summary: the purpose of this pilot study is to evaluate the impact of reining in anxiety for children with anxiety and their caregivers. a total of up to 80 child/caregiver dyads will be enrolled in the study, anticipating that 40 dyads will complete the 10 week intervention. the intervention will be delivered at fieldstone farm therapeutic riding center, which is one of the largest therapeutic riding centers in the us.

reining in anxiety is a manualized equine assisted therapy (eat) for childhood anxiety. the manual and associated materials are being tested in this pilot study, and, if found to be successful, will be available for public consumption. this eat, which is delivered in a group setting, combines therapeutic horseback riding with cognitive behavioral strategies for anxiety. the group meets weekly over the course of ten weeks, with each session lasting 45 minutes. each session is delivered in a group format with up to four children between 6 and 17 years of age.

Eligibility criteria:
inclusion criteria: * caregiver/child dyads where the children are between six and 17 years of age and their caregivers will be enrolled in the study. * children must have a score of 3 or higher as measured by the gad-2, * children must have a minimum level of functioning as measured by the cgas of 41 or higher. exclusion criteria: * an inability to provide informed consent
a study of inotuzumab ozogamicin plus rituximab for relapsed/refractory aggressive non-hodgkin lymphoma patients who are not candidates for intensive high-dose chemotherapy

Conditions: Lymphoma, Non-Hodgkin

Summary: the purpose of this study is to evaluate the efficacy of inotuzumab ozogamicin plus rituximab in relapsed/refractory aggressive non-hodgkin lymphoma patients who are not candidates for intensive high-dose chemotherapy. specifically, the goal is to demonstrate the superiority of this combination compared with an active comparator arm (investigator's choice of rituximab+bendamustine or rituximab+gemcitabine) using the primary endpoint of overall survival.


Eligibility criteria:
inclusion criteria: - exclusion criteria: -

Keywords: inotuzumab ozogamicin aggressive non-hodgkin lymphoma diffuse large b-cell lymphoma relapsed/refractory lymphoma
age gene/environment susceptibility reykjavik study

Conditions: Neoplasms

Summary: 5764 men and women in iceland, aged 66 to 96 years entered the ages gene/environment susceptibility (ages) - reykjavik study. serum 25(oh)d was measured in 5,519 of all 5,764 (96%) participants at study entry in year 2002 through 2006. the main emphasis was on exploring whether pre-diagnostic serum levels of 25(oh)d were associated with survival after cancer diagnosis.


Eligibility criteria:
inclusion criteria: * to participate in the ages-reykjavik study exclusion criteria: * to be diagnosed with cancer before study entry

Keywords: vitamin d cancer survival