Kornimate/medical-research-clean huggingface dataset:
maximal exercise capacity, physical activity and respiratory muscle strength in peripheral artery disease

Conditions: Peripheral Arterial Disease

Summary: the primary aim of the study is to evaluate the maximal and submaximal exercise capacity in patients with peripheral artery disease (pad). the secondary aim of the study is assessment of physical activity level, respiratory function, peripheral and respiratory muscle strength, respiratory muscle endurance, depression, quality of life, intermittent claudication and cardiovascular risk factors in patients with pad.

peripheral artery disease is characterized by reduced exercise capacity, physical activity level and intermittent claudication. the number of studies investigating maximal and submaximal exercise capacity and physical activity level in pad is limited. there is also no study investigated pulmonary functions, respiratory muscle strength and endurance in this patient population. according to the sample size analysis 15 patients and 15 healthy individuals with similar demographic characteristics will be included the study. patients and healthy individuals will be selected according to predetermined inclusion and exclusion criteria. the assessments will be completed in two days.maximal exercise capacity will be assessed using cardiopulmonary exercise testing (cpet), functional exercise capacity using six minute stepper test, physical activity using multi-sensor activity monitor, pulmonary function using spirometry, respiratory muscle strength using mouth pressure device, peripheral muscle strength using hand held dynamometer, respiratory muscle endurance using incremental threshold loading test, depression using beck depression inventory (turkish version), life quality using sf-36 health survey (turkish version), intermittent claudication using walking impairment questionnaire (turkish version)

Eligibility criteria:
inclusion criteria: patients; * diagnosed with peripheral artery disease * ankle brachial index (abi)≤ 1,5 or calcified vessel response * clinically stable and under standard medication patients will be included exclusion criteria: patients with; * ischemic amputation * any pulmonary disease * unstable coronary artery disease * orthopedic and neurological problems * acute infection * myocardial infarction or major surgery in the last 3 months will be excluded healthy controls: ages 18-80 years will be included * with any diagnosed disease and smoking more than 10 packsyears will be excluded

Keywords: peripheral arterial disease exercise capacity physical activity respiratory muscle strength peripheric muscle strength
pilot study: a telehealth intervention for caregivers of infants with early signs of autism spectrum disorder

Conditions: Autism Spectrum Disorder; Developmental Delay

Summary: caregiver coaching will be provided using telehealth technology, in order to determine the efficacy and effectiveness of the telehealth medium of intervention delivery for caregivers of infants with concern for asd.

ideally, all caregivers with an infant identified with concern for asd would have immediate access to good quality caregiver coaching provided in the most natural environment possible. however, this is currently not the case for the majority of families. there are no empirically validated treatment programs for infants showing asd risk. the proposed research project will use applied behavior analysis-based single-subject experimental designs to further develop a promising caregiver-mediated intervention designed for infants showing early signs of asd. caregiver coaching will be provided using telehealth technology, in order to maximize recruitment opportunities and to determine the efficacy and effectiveness of the telehealth medium of intervention delivery for caregivers of infants with concern for asd.

Eligibility criteria:
inclusion criteria: * infants must exhibit early symptoms of asd as indicated by a combination of autism observation scale for infants (aosi) scores of 7 or higher * and infant toddler checklist (itc) scores in the autism concern range * expression of clinical concern about asd risk by the assessor and caregiver * caregivers must be identified as the infants' primary caregivers * caregivers be english speaking * caregivers must have access to wired or wireless network technology to access the internet in their homes. exclusion criteria: * infants may not have had significant abnormalities in the pre-, peri-, and postnatal period or gestational age younger than 34 weeks * infants may not have serious medical conditions involving repeated or lengthy hospitalizations, head injuries, seizures, cerebral palsy or impaired hand use * infants may not have multiple daily administrations of medical treatment (e.g., nebulizers daily) * infants may not have known genetic syndrome associated with asd (e.g., fragile x syndrome) infants may not have moderate to severe visual, auditory, or motor impairments * a caregiver may be excluded from participation if the caregiver is engaging in the majority of all possible caregiver treatment target behaviors at therapeutic levels during intake (fidelity of implementation scores of 80% or higher on each caregiver target behavior).
comparison of antibiotic protocols in spine patients with postoperative drains

Conditions: Surgical Wound Infection; Spinal Deformity; Spinal Degeneration

Summary: in spine surgery, postoperative spinal drains are often utilized to prevent fluid buildup around the spinal cord. the purpose of this study is to determine whether postoperative antibiotic treatment continued for the duration of time a drain is in place results in a lower infection rate than antibiotics given for only 24 hours postoperatively.

patients likely to receive postoperative spinal drains were enrolled and randomized preoperatively to receive one of two postoperative antibiotic treatments, either for 24 hours after surgery or for the duration of time the spinal drain was in place. if patients did not receive at least one spinal drain during surgery, they were excluded from the infection analysis and received the institutional standard of 24 hours of postoperative antibiotics. patients that did receive drains were treated according to their randomization and followed for a minimum of one year for the incidence of surgical site infection. the diagnosis of surgical site infection was determined using the definition provided for the center for disease control (cdc). all patients that developed surgical site infections were treated as appropriate by the attending physician.

Eligibility criteria:
inclusion criteria: * must be scheduled to undergo spine surgery with likely drain placement (3 or more vertebral levels, dependent upon attending surgeon) * must be over the age of 18 * must consent to randomized postoperative antibiotic treatment exclusion criteria: * does not receive a drain at the time of surgery * surgery is cancelled * infection is present at the time of initial surgery

Keywords: surgical site infection spinal surgery prophylactic antibiotics postoperative spinal drains
active retirement: effects of the application of a training program

Conditions: Training; Sensorimotor Disorder

Summary: the study will include 160 participants. they will be randomized into 2 groups, experimental and control. the intervention will take place over 24 weeks. parameters of body composition, quality of life, physical activity, strength, flexibility, postural control, gait, agility and execution speed will be determined.

the intervention study will have a quasi-experimental, longitudinal and controlled design. the sample will participate in a supervised training program lasting 24 weeks, followed by a 1-year follow-up period. the sample will be divided into two groups, intervention group and control group. the variables under study are physical activity in the last week; quality of life; lower and upper limb strength; flexibility of the lower and upper limbs; postural control; march; agility and execution speed. these variables will be evaluated in 4 moments: before the beginning of the training program; after 24 weeks of the program; after 6 months from the end of the program; and after 1 year. a convenience sample will be recruited in the community of almada, in partnership with the municipality of almada (cma). the sample will be recruited according to the following inclusion criteria: residents in the municipality of almada, individuals between 55 and 80 years of age, healthy people, who do not have prostheses (with the exception of dental prostheses), who have not undergone operations for over 6 months, and who can walk independently for up to 10 minutes. participants will not be eligible if they are younger than 55 years of age or older than 80 years of age, have a musculoskeletal or neurological diagnosis and report a clinical cardiovascular diagnosis. gender is not an exclusion criterion. the training program will be carried out over a period of 24 weeks, with exercise sessions twice a week, lasting approximately 45 minutes each. the sessions were divided into three phases: initial phase; fundamental phase; and return to calm. throughout the intervention, the sensorimotor training program will have a progressive increase in load, the exercises will be divided into 3 levels of intensity: easy, intermediate and advanced.

Eligibility criteria:
inclusion criteria: * aged between 55 years and 80 years; * agree to participate in the study; * healthy people; * people without prostheses (with the exception of dental prostheses); * people who have not been operated on for less than 6 months. exclusion criteria: * people with musculoskeletal diagnosis; * people with problems in locomotion; * psychiatric diseases and neurological disorders; * people with a clinical cardiovascular diagnosis.

Keywords: aging quality of life sensory motor training
use of mosquito net mesh for ventral hernia repair

Conditions: Hernia, Ventral; Ventral Incisional Hernia

Summary: it´s a pilot study, randomized, realized in the central hospital "dr. ignacio morones prieto", slp, mexico. hypothesis: the polyethylene mesh is secure in open ventral repair.

it´s a pilot study, randomized, realized in the central hospital "dr. ignacio morones prieto", slp, mexico. the simple size for pilot study was been calculated in 20 patients, according with browne for not knowing the variability of the treatment. 10 patients in the group of polypropylene mesh (prolene ®), braided monofilament thread, macropore, weight of 108.1 g/m2, fibres diameter of 0.53 mm, tensile force of 156.6 n/cm, with a pore of 1.6 mm2, in different size of 15 x 15 cm, 20 x 20 cm and 30 x 30 cm, and 10 patients in the group of mesh of pebd (mosquito net), braided monofilament thread, macropore, ,weight of 53.7 g/m2, fibers diameter of 0.48 mm, tensile force of 42.7 n/cm and pore of 1.8 mm2, in different size 15 x 15 cm, 20 x 20 cm and 30x 30 cm donated by dr. ravindranath r. tongaonkar. the sterilization were done in ethylene oxide. the randomisation for allocation the type of mesh for each patient was realized with numbers generated by computer with the program r version 3.0.2 with the simple function. the statistical analysis was carried out by the programs: jmp 8 (sas institute inc., cary, nc, usa) and r 2.15.1 23. the ventral hernia repair were carried out with standardized technique, placed the mesh int the preperitoneal or retromuscular space fixing with 2-0 poplypropylene suture and le fe active-close drainage, 30 minutes before the incision, prophylactic antibiotic 1gm of cefalotin was administered, in both groups, the patient was discharge at the first postoperatory day with drainage and retired at the first review at 1 week and recited at one, three, six and twelve months for reviewer. the descriptive analysis of categorical variables was expressed with frequencies and percentages; the numerical ones with normal distribution in averages and standard deviation, the variables with distribution not normal with medians and status (maximum and minimal values). the values of p\<0.05 were considered to be significant. this study was evaluated and accepted by the committee of investigation and the committee of ethics, with number of record 42-17.

Eligibility criteria:
inclusion criteria: * all the patients with primary or incisional elective ventral hernia repair with mesh were included, with asa i,ii and iii between 18 and 75 years, of any sex, and that they accepted to take part in the protocol and signed the informed assent. exclusion criteria: * we excluded patients with incarcerated, strangulated hernia, signs of intestinal obstruction, consumption of anticoagulants, imc \>35, parastomal hernias, hernia repair with intestinal reconnections at the same procedure or presented infection in abdominal wall.

Keywords: mosquito net mesh polypropylene mesh prolene mesh ventral hernia hernia
effectiveness of interscalene brachial plexus block and intra-articular injection of ropivacaine for post-operative analgesia in arthroscopic shoulder stabilization surgery

Conditions: Postoperative Analgesia

Summary: this study evaluates two anaesthetic techniques namely interscalene brachial plexus block and intra-articular local anaesthetic injection. both techniques are currently used for providing postoperative pain relief following arthroscopic shoulder stabilisation operation. it will be a randomised controlled trial involving 30 patients in two groups.


Eligibility criteria:
inclusion criteria: • all adult patients above the age of 18 years undergoing arthroscopic shoulder stabilisation operation exclusion criteria: * patients not meeting inclusion criteria * patients unable to give informed consent * patient refusal to participate in the study * contraindications to interscalene block * allergy to local anaesthetics * peripheral neuropathy from any cause * patients on opiates for chronic pain * pregnant women
an in-shoe device to monitor toe-walking in children with cerebral palsy

Conditions: Children With Cerebral Palsy

Summary: the present project will focus on evaluating the technical efficacy of the in-shoe gait monitoring device (activegait) through laboratory based biomechanical gait assessments of children who exhibit gait deviations due to cp or idiopathic toe walking wearing the device.

the investigators on this protocol intend to develop the device and rely on it to propose a toe walk severity (tws) index, a novel outcome measure for quantifying changes in severity of toe walking over time and for assessing the outcome of surgical and non-surgical interventions. tasks include: a.validate data acquisition measurements in laboratory setting compared to gold-standard video analysis and field (outside of laboratory). b.develop multi-stage classification algorithm from subset of laboratory and field data. c.validate classification algorithm against random subsets of laboratory and field data. d.explore the development of a toe walking severity (tws) index from available biomechanical and activegait data for different ambulatory conditions. e.perform longitudinal study of the childhood toe walking population including both laboratory analysis and at-home monitoring using activegait technology. f.analyze statistically the sensitivity and specificity of the tws index compared to clinical observations. gather evidence that the tws index provides a means to track changes in severity of toe walking over time.

Eligibility criteria:
inclusion criteria: * able to ambulate 50 feet on level ground without the assistance of a person * able to ambulate on ramps and stairs without the assistance of a person * demonstrate a toe-walking pattern at the time of enrollment * medically stable * able to understand directions and follow simple instructions exclusion criteria: * any cardiopulmonary, orthopedic, and neurological conditions other than cp that would prevent them from performing the motor tasks of interest

Keywords: cerebral palsy home monitoring gait sensorized shoe
outcomes after standard and high-flexion posterior stabilized rotating-platform mobile-bearing total knee arthroplasty

Conditions: Osteoarthritis, Knee

Summary: the aim of this prospective study is to compare the clinical and radiographic outcomes of standard and high-flexion posterior stabilized (ps) rotating-platform mobile-bearing (rp-mb) total knee arthroplasty. the investigators hypothesize that total knee arthroplasty performed with a high-flexion ps rp-mb design would improve range of motion, and that this would be reflected by a better clinical outcome and greater patient satisfaction.

a high-flexion, ps rp-mb prosthesis was designed to improve range of motion after total knee arthroplasty without compromising the theoretical advantages of the standard ps rp-mb system. to date, no study has prospectively compared the clinical and radiographic results of standard and high-flexion ps rp-mb designs.

Eligibility criteria:
inclusion criteria: * a diagnosis of primary osteoarthritis of knee * a candidate for total knee replacement arthroplasty exclusion criteria: * a diagnosis other than primary osteoarthritis * a history of previous open knee surgery

Keywords: arthroplasty replacement knee range of motion
the safety and efficacy of pemetrexed rechallenge with bevacizumab

Conditions: Advanced Non-small Cell Lung Cancer

Summary: for patients with nonsquamous nsclc and a good performance status (ps), pemetrexed and cisplatin has been recommended for first-line nsclc treatment. recently, results from the paramount trial showed that patients with nonsquamous nsclc who had a good ps and had not progressed after completing four cycles of pemetrexed-cisplatin induction therapy benefitted from pemetrexed continuation maintenance therapy. furthermore, pemetrexed with bevacizumab continuous maintenance might be better treatment option, considering the results from avapearl trial. pemetrexed rechallenge has been reported to be effective in some patients. therefore, in order to investigate the safety and efficacy of pemetrexed rechallenge with bevacizumab,we conducted this study.


Eligibility criteria:
inclusion criteria: * 20 years and older * ps0-2 * advanced non-squamous non-small cell lung cancer; and * patients who have received more than 4 cycles of pemetrexed therapy before the study exclusion criteria: * interstitial pneumonia; and * abnormal blood test
multi-strain probiotics to prevent necrotizing enterocolitis in very preterm infants

Conditions: Necrotizing Enterocolitis (NEC)

Summary: the goal of this clinical trial is to evaluate whether multi-strain probiotics of lactobacillus and bifidobacterium can prevent necrotizing enterocolitis (nec) in preterm infants born at less than 32 weeks of gestation. the main questions it aims to answer are: * does the use of a multi-strain probiotic combination reduce the incidence of nec in preterm infants? * are there any adverse effects associated with the administration of this probiotic combination?

researchers will compare outcomes between two phases: control phase: no probiotics will be administered, and outcomes will be recorded to establish baseline nec rates. intervention phase: participants will receive a daily multi-strain probiotic combination (0.5 g sachet) starting within 24 hours of enteral feeding initiation. participants will be: * preterm infants born at \<32 weeks' gestation and \<1500 g birth weight. the study uses a stepped-wedge cluster randomized trial (sw-crt) design, where neonatal intensive care units (nicus) transition from the control phase to the intervention phase at pre-specified intervals. individual consent will be obtained for probiotic administration and data collection during the intervention phase, and data collection-only consent will be sought during the control phase. this trial is designed to provide high-quality evidence on the efficacy and safety of probiotics in preventing nec in preterm infants.

Eligibility criteria:
inclusion criteria: * infants born between \<32 0/7 weeks gestation. exclusion criteria: * major congenital or chromosomal abnormalities * conditions affecting gastrointestinal systems that prohibit infants from starting on feed in the first 72 hours after birth.

Keywords: probiotics necrotizing enteroclitis preterm infants
the effect of dexmedetomidine on brachial plexus block for shoulder surgery

Conditions: Nerve Pain; Shoulder Pain

Summary: the purpose of this study is to determine whether a small dose of dexmedetomidine, when given either intravenously or as part of the interscalene nerve block solution, prolongs pain relief following shoulder surgery compared to local anesthetic solution alone.

unilateral shoulder surgical procedures, including acromioplasty, rotator cuff repair and bankart procedure generally allow the patient to go home the same day. however, post-surgical pain is often severe and it is common to encounter a delay in discharge from the hospital due to difficulty in pain control. single shot interscalene block is used in ambulatory shoulder surgery for its advantages that included a significant reduction in acute pain and analgesic requirements, prolonged time to first analgesic request, decreased incidence of nausea, as well as earlier hospital discharge. previous studies have attempted to prolong the duration of the analgesia of interscalene block by administering additional drugs to the local anesthetics but these studies have had varying degrees of success. dexmedetomidine has recently been considered as a potentially useful drug in prolonging nerve block analgesia. various modes of administration of dexmedetomidine have demonstrated a consistent effect on the duration of analgesia. so far, the systemic infusion of dex has been shown to prolong both neuraxial and peripheral nerve blocks. when combined with local anesthetics in intravenous regional anesthesia 9ivra), dex enhanced the duration of analgesia. furthermore, data from animal studies strongly support the use of dex as a safe potent adjunct to local anesthetics capable of prolonging the duration of analgesia of peripheral nerve blocks. the use of dexmedetomidine as an adjunct in interscalene block has not been studied yet. this trial will study the effects of adding dexmedetomidine as an adjunct to local anesthetics in interscalene brachial plexus block.

Eligibility criteria:
inclusion criteria: * unilateral surgical shoulder procedures under general anesthetic * english speaking patients * asa i-iii patients * bmi \<38 kg/m2 exclusion criteria: * proximal clavicular surgery * preexisting neurological deficits or peripheral neuropathy * known coronary heart disease, congestive heart failure, cardiomyopathies, or arrhythmias * known cerebrovascular disease * baseline heart rate \<60 beats per minute or baseline systolic blood pressure \<100 mm hg * medications that reduce heart rate (as beta-blockers, calcium blockers) known liver dysfunction or existing diseases known to cause hepatic or renal impairment * severe bronchopulmonary disease * local infection * contra-indication to regional anesthesia (bleeding, coagulopathy) * chronic pain disorders * current use of over 30mg oxycodone or equivalent per day * contraindication to a component of multimodal analgesia * allergy to local anesthetics or dexmedetomidine * history of significant psychiatric conditions that may affect patient assessment * pregnancy * inability to provide consent

Keywords: duration of analgesia