Kornimate/medical-research-clean huggingface dataset:
comparison of two exercise therapy protocols in patients with bruxism

Conditions: Bruxism

Summary: the main purpose of this planned research is to investigate the effectiveness of three different methods used for the treatment of bruxism. two of these are physiotherapy-specific exercise treatment protocols (1.posture and proprioception exercises 2. jaw area strengthening exercises) and a control group, (occlusal splint therapy) will take place during the study.

the current study is planned as a parallel group, randomized controlled trial. patients who apply to adnan menderes university faculty of dentistry between june 2022 and january 2023 and diagnosed with bruxism after the examination will be screened for the study. aydın adnan menderes university faculty of dentistry is a hospital that serves an average of 400 patients per day.

Eligibility criteria:
inclusion criteria: 1. diagnosis of sleep bruxism according to the criteria of the international classification of sleep disorders (icsd) of the american academy of sleep medicine (aasm) (5); 2. 18-50 age range 3. the diagnosis of awake bruxism, which was determined by a positive answer to the questions of the questionnaire developed according to pintado's recommendations (6); 4. pain around the jaw is 3 or more on the visual analog scale (7) 5. patients who volunteered to participate in the study exclusion criteria: 1. systemic and/or degenerative disorders 2. neurological or psychiatric diseases (excluding anxiety and depression) 3. use of drugs that affect sleep or motor behavior 4. arthrogenic or mixed temporomandibular disorder 5. axis i myogenic tmd according to investigational diagnostic criteria for temporomandibular disorders (rdc/tmd) 6. patients using total prosthesis 7. direct trauma or previous surgical intervention in the orofacial region 8. patients using muscle relaxants and non-steroidal anti-inflammatory drugs. 9. patients using removable prostheses 10. patients who have received any treatment for bruxism 11. patients who did not want to participate in the study

Keywords: bruxism physiotherapy exercise therapy occlusal splint pain rehabilitation
covid-19 psychological wellbeing for healthcare students

Conditions: Psychological Wellbeing

Summary: we have developed an online learning resource designed to support healthcare staff during and after the covid-19 pandemic. this resource has been produced in anticipation of the psychological effect of working during this time. this is an open access, free, online resource available here: https://www.nottingham.ac.uk/toolkits/play_22794 it is designed to be relevant for healthcare staff, and we are evaluating it now with healthcare students as our next generation of healthcare staff. we are interested in knowing more about your views of healthcare students towards this package. this will help us to determine its value as a learning resource to support psychological wellbeing in healthcare students, alongside other welfare supports. the aim is to describe the views of healthcare students towards an e-learning package developed in response to covid-19 on psychological wellbeing for healthcare workers.

the investigators aim to: * gather insight into the emotional highs and lows of being a healthcare student during the pandemic * identify any facilitators, obstacles or barriers to accessing the e-package. * identify perceptions of healthcare students towards the value of the e-package during and after the covid19 pandemic. * establish recommendations for longer-term support for psychological wellbeing in healthcare students. qualitative interviews will be conducted with up to 45 purposively sampled healthcare students who have accessed the e-learning resource. the interview will be semi-structured and include a measure of mental wellbeing (warwick-edinburgh wellbeing scale, 14-item - license received), and single items measures of job stressfulness, job satisfaction, presenteeism, turnover intentions and work engagement. findings will inform future supportive interventions for healthcare students.

Eligibility criteria:
inclusion criteria: * healthcare students (e.g. any students who are registered on a healthcare course). * ability to give informed consent. * ability to attend an individual interview (remotely). exclusion criteria: • not a registered healthcare student.
compare anti-inflammatory dentifrices

Conditions: Gingivitis

Summary: plaque induced gingivitis


Eligibility criteria:
inclusion criteria: * subjects must be adult males or females 18 to 60 years old * subjects must be able and willing to follow study procedures and instructions * subjects must have read, understood and signed an informed consent form * subjects must have generalized, moderate plaque-associated gingivitis as determined by the investigator or designee during the screening examination * subjects must present with at least 20 teeth in the functional dentition, excluding third molars * each subject must have at least four teeth with probing depths of 4-5 mm and at least 30% of sites bleeding to gentle probing exclusion criteria: * subjects who have chronically used (i.e., two weeks or more) total (triclosan/copolymer) dentifrice within 6 months prior to enrollment * subjects with gross oral pathology, including widespread caries or chronic neglect, extensive restoration, pre-existing gross plaque and calculus, or soft or hard tissue tumor of the oral cavity * subjects with periodontitis as indicated by periodontal pocketing 6 mm at screening * subjects with a history of early onset periodontitis or acute necrotizing ulcerative gingivitis * subjects with concomitant endodontic or periodontal therapy other than prophylaxis within 6 months prior to enrollment * subjects with orthodontic appliances or removable partial dentures * subjects chronically treated (two weeks or more) with any medication known to affect inflammation or periodontal status or (aspirin, nonsteroidal anti-inflammatory drugs, steroids, statins, phenytoin, calcium antagonists, cyclosporin and coumadin) within one month of the screening examination. all other medications for chronic medical conditions should be initiated at least three months prior to enrollment * subjects who currently smoke or who report using tobacco products within one year of screening. * subjects who have been treated with antibiotics for medical or dental reasons within 3 months prior to enrollment * subjects having clinically significant or unstable organic disease; subjects having compromised healing potential such as those with diabetes mellitus or connective tissue disorders; subjects having heart murmurs, histories of rheumatic fever, valvular disease or prosthetic joint replacement necessitating antibiotic prophylaxis * female subjects who report being pregnant or lactating, or female subjects who are of childbearing potential and who report not using hormonal or barrier methods of birth control (oral or parenteral contraceptives, diaphragm plus spermicide, condoms) * subjects who use hormonal contraceptives must have started the method 30 days prior to the screening examination. * subjects with active infectious diseases such as hepatitis, human immunodeficiency virus or tuberculosis * subjects diagnosed with human immunodeficiency virus (hiv) or subjects that are immunocompromised as determined by the investigator * medical condition which precludes not eating/drinking for approximately 8 hours.
mirena® ± metformin as fertility-preserving treatment for young asian women with early endometrial cancer

Conditions: Endometrial Cancer

Summary: primary objective to discover the efficacies of levonorgestrel-containing intrauterine device (lng-ius, mirena®), with or without metformin, as fertility-preserving treatment for grade 1 endometrioid adenocarcinoma of endometrium, ct1an0m0 with presumed no myometrial invasion on image study (mri preferred). secondary objectives 1. to discover the morphological and molecular change in the endometrium tumor before and after treatment 2. to discover the effectiveness of adding oral progestin to subjects who show no good response to assigned 3. to compare (1) the systemic effects, including body weight change, neuropsychiatric alternation, gi disturbance, skin disorder, change in serum metabolic and hepatic markers between the two study patient groups; (2) the rate of long-term success defined as (a) sustained remission of \>= 12 months starts from the histologic documentation of complete remission (b) rate of pregnancy and (c) alive baby delivery, based on time-to-event analysis. 4. molecular markers and their expression before, during and after treatment, including progesterone b receptor, progesterone a receptor, estrogen receptor, ki67, pten and its related markers, bcl2 and its related markers and other developing markers. this is to discover prediction markers to medical treatment.


Eligibility criteria:
inclusion criteria: 1. women \<= 40 years old with histologic confirmed grade 1 endometrioid adenocarcinoma of the endometrium 2. tumour is confirmed to the endometrial cavity with no evidence of metastasis on mri and/or trans-vaginal ultrasonography 3. ecog 0-1, adequate organ function, with fertility preserving need 4. immunohistochemical study showed positive progesterone receptor and positive estrogen receptor in the endometrial tumour tissue 5. serum ca 125 titre is within normal limit 6. signed informed consent exclusion criteria: 1. women age \> 40 years or endometrial cancer other than grade 1 endometrioid adenocarcinoma 2. suspected lymph node metastasis or other metastasis appears in image study 3. ovarian tumour in image study 4. blurred junction between the endometrium and the myometrium on image study, with the impression that myometrial invasion of the endometrial tumour cannot be ruled out 5. ultrasonographic study or mri show obvious adenomyosis or ovarian endometriosis 6. women who are contraindicated to receive study treatment because of intolerance to treatment agents, medical co-morbidity or other reason(s) 7. women with history of or concurrent with malignancy other than skin basal cell carcinoma 8. women who cannot participate regular follow-up

Keywords: endometrial cancer.mirena®
effects of virtual reality and nature sounds on pain and anxiety in women having cesarean section

Conditions: Obstetrics and Gynaecology; Nursing; Caesarean Section; Pain; Anxiety

Summary: this study will be conducted to determine the effects of virtual reality application on pain and anxiety in postpartum women after cesarean section. it will be applied to women who have had a cesarean section and who volunteered to participate in the study and were randomly assigned to intervention (n=40) and control (n=40) groups in a faculty hospital and a state hospital in turkey. the use of virtual reality glasses will be taught to the postpartum women in the intervention group. after the initial mobilization, the postpartum women will be shown a nature view video with virtual reality glasses (vrg) accompanied by nature sounds for 20 minutes. the aim of this application is to enable women to watch nature images more effectively accompanied by nature sounds, thus allowing them to focus on the images and sounds, distract them, relax and remove them from the tension of the current environment. the application will be performed with the women in a semi-recumbent position and without sleeping. the same application will be applied to each woman and the glasses will be disinfected with dermosept surface disinfectant, which provides cold sterilization, before the application. no application will be applied to the control group; only the general routine maintenance of the hospital will be performed. data will be collected by the researcher through face-to-face interviews based on the statements of the women after cesarean section.


Eligibility criteria:
inclusion criteria: * volunteering to participate in the study * being over 18 years of agebeing able to read and write in turkish * giving birth at term, having a single, live and healthy baby * the baby being with the mother * having a healthy/risk-free pregnancy * having had spinal anesthesia. exclusion criteria: * having a diagnosed psychiatric disease, * having a mental disability and communication problem, * having a vision or hearing problem, * developing complications during or after a cesarean section, * having any obstacles to postpartum mobilization.

Keywords: pain anxiety caesarean section nurse virtual reality nature sounds
effects of underwater ultrasound therapy on hand function and quality of life in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: in this randomized, double-blind, placebo-controlled study the effects of underwater ultrasound (us) therapy were investigated in 48 patients with moderately active rheumatoid arthritis (disease activity score in 28 joints (das28) ≥3.2 and ≤5.1). patients randomly assigned to the ultrasound group (n=25) received underwater ultrasound therapy to both wrists and hands for 7 minutes per session with an intensity of 0.7 w/cm2 during 10 sessions. the control group (n=23) received sham treatment under the same conditions. at baseline, at the end of treatment (week 2) and at the follow-up visit (week 14), the following parameters were evaluated: disease activity - erythrocyte sedimentation rate (esr), c-reactive protein (crp), tender and swollen joint counts, pain on a visual analogue scale, and das28, hand function (fist making, wrist extension and flexion, hand grip strength), quality of life - health assessment questionnaire (haq), and the patients rated their own condition.


Eligibility criteria:
inclusion criteria: * patients over 18 years of age with mild-to-moderate (das28 \> 3.2 and \< 5.1) rheumatoid arthritis meeting the american college of rheumatology (acr) diagnostic criteria * no distinction was made between seropositive and seronegative patients (regarding rheumatoid factor and anti-citrullinated peptide antibody) * a stable-dose pharmacotherapy (dmards therapy), nsaids, steroid) given for at least 2 months * no physiotherapy within 1 month before starting the study exclusion criteria: * included high disease activity (das28 \> 5.1) and remission (das28 \< 2.6) * other concomitant autoimmune diseases * stable-dose pharmacotherapy for less than 2 months * conditions contraindicating us therapy (severe osteoporosis when t-score \< -3.5; infection; fever; osteomyelitis; pregnancy; untreated high blood pressure) * physiotherapy within 1 month before starting the study

Keywords: underwater ultrasound rheumatoid arthritis
music therapy advocacy recording intervention (mtar) on internalized stigma

Conditions: Mental Health Issues; Bipolar Disorder; Depressive; Schizophrenia Spectrum and Other Psychotic Disorders; Anxiety Disorder

Summary: this study will use a systematic music therapy intervention on patients with mental illness trying to help them with their internalized stigma.

the primary objective of this study is to determine the effect of a systematic music therapy intervention on internalized stigma of mental illness. the secondary objective is to evaluate the potential for the treatment effect to vary across subject diagnostic categories. this study will also examine the ability of the treatment effect to persist after 3 weeks as an exploratory objective. data collection will be conducted in the acute care unit (acu) of hackensack meridian health carrier clinic (hmhcc) over a period of ten months. subjects will be drawn from the pool of patients admitted to the hmhcc acu during that time. adults aged 18-65 with severe mental illness with a diagnosis of bipolar or a related disorder, depressive or anxiety disorder, or schizophrenia spectrum or other psychotic disorders as defined by the diagnostic and statistical manual of mental disorders version 5 (dsm-5 : 5th ed.; american psychiatric association, 2013), of prolonged duration with a significant degree of disability or social dysfunction (ruggeri et al., 2000) are eligible to participate. eligible participants must be able to provide informed consent as determined by the doctor.

Eligibility criteria:
inclusion criteria: * admitted to the hmhcc acu * able to read and comprehend the ismi questionnaire, provide informed consent, * with a severe mental illness of prolonged duration with a significant degree of disability or social dysfunction exclusion criteria: * patients on s1 status (1:1 patient observation) or isolation protocol * evidence of organic brain disease, severe acute symptomatology, hearing deficit, and intellectual disability.

Keywords: internalized stigma music therapy music therapy advocacy recording intervention schizophrenia spectrum and other psychotic disorders mental health issues
monitor patients with acute heart failure

Conditions: Heart Failure

Summary: this is a prospective, multi-center, non-randomized study to evaluate performance of an external monitor for heart failure patients

external monitoring of heart failure patients with the avivo system.

Eligibility criteria:
inclusion criteria: * is female or male, 18 years of age or older * has an ejection fraction of 40% reported within 12 months of enrollment * having acute decompensated heart failure and receiving treatment for fluid overload exclusion criteria: * is participating in another clinical study that may confound the results of this study
fertility-sparing in early-stage cervcial cancer: the eternity project

Conditions: Cervical Cancer

Summary: the eternity project is a retrospective analysis of outcomes of patients undergoing fertility-sparing treatment for cervcial cancer. the primary aim is to report outcomes of those patients. other aims included: 1. evaluation about the effectiveness of different treatment modalities; 2. evaluation of outcomes according to different stages of disease; 3. evaluation of the impactof neoadjuvant chemotherapy in patients undergoing conservative surgery


Eligibility criteria:
inclusion criteria: * histological confirmed cervical cancer * figo stage ia1-ib3 * fertility-sparing (conization plus nodal dissection) exclusion criteria: * age less than 18 yrs * age more than 50 yrs
controlled study of ono-5920 in patients with involutional osteoporosis in japan

Conditions: Involutional Osteoporosis

Summary: the purpose of this study is to evaluate the efficacy and safety of ono-5920 in patients with involutional osteoporosis.


Eligibility criteria:
inclusion criteria: 1. patients who was included in study ono-5920-02 and completed the medication for two years 2. other inclusion criteria as specified in the study protocol exclusion criteria: 1. patients judged to be unsuitable by safety evaluation as clinical trial subjects by the investigator 2. patients having secondary osteoporosis or another condition that presents low bone mass 3. other exclusion criteria as specified in the study protocol

Keywords: ono-5920 osteoporosis bisphosphonate
a prospective, non-interventional survey to evaluate injection intervals and treatment modalities of botulinum toxin a (bont-a) in adult patients suffering from upper limb spasticity after stroke

Conditions: Upper Limb Spasticity After Stroke

Summary: the purpose of the protocol is to evaluate injection intervals and treatment modalities up to 3 years follow-up of botulinum toxin a (bont-a) in adult patients suffering from upper limb spasticity after stroke.


Eligibility criteria:
inclusion criteria: * subject able to comply with the protocol * provision of written informed consent prior to collecting the data * male or female patients of 18 years or older * presenting with upper limb spasticity after stroke for which treatment with botulinum toxin a is indicated exclusion criteria: * the subject has already been included in this survey * patients who already received bont-a treatment for upper limb spasticity * patients with known intolerance for bont-a * subjects unable to comply with the protocol
high versus low spo2 oxygen therapy in patients with acute heart failure

Conditions: Heart Failure

Summary: the primary objective of this pilot trial is to determine whether inpatients presenting to the emergency department (ed) with symptoms suggestive of acute heart failure (ahf), who receive supplemental oxygen adjusted at either a high (spo2 range ≥96%) or low (spo2 range 90-92%) oxygen saturation level, leads to greater reduction in n-terminal-probnp (nt-probnp) at 72 hours.

patients will be randomized to either a high (spo2 range ≥96%) or low (spo2 range 90-92%) oxygen after informed consent.

Eligibility criteria:
inclusion criteria: * \>40 years of age presenting to the ed with ahf * objective finding of hf (bnp \>400 pg/ml or chest x-ray with pulmonary congestion) * plan to admit with primary diagnosis as hf * must be able to be randomized within 16 hours of presenting to the ed * provided written informed consent exclusion criteria: * on home oxygen * known prior hypercapnic failure (paco2 \>50 mmhg) * asthma * primary pulmonary hypertension, * patients who require urgent positive pressure ventilation or intubation * patients on \>10 l/min oxygen

Keywords: acute heart failure
a study to evaluate efficacy, safety, pharmacokinetics, and pharmacodynamics of multiple doses of natalizumab (bg00002) administered subcutaneously to japanese participants with relapsing-remitting multiple sclerosis

Conditions: Multiple Sclerosis, Relapsing-Remitting

Summary: the primary objective of this study is to evaluate the efficacy of natalizumab 300 milligrams (mg) subcutaneous (sc) every 4 weeks (q4w) administrations up to 24 weeks in japanese participants with relapsing-remitting multiple sclerosis (rrms). the secondary objectives of the study are to evaluate other clinical and magnetic resonance imaging (mri) measures of efficacy of natalizumab 300 mg sc q4w administrations in japanese participants with rrms, to evaluate the safety, tolerability, and immunogenicity of natalizumab 300 mg sc q4w administrations up to 48 weeks in japanese participants with rrms, to evaluate the pharmacokinetics (pk) and pharmacodynamics (pd) of natalizumab 300 mg sc q4w administrations up to 24 weeks and for an additional 24 weeks in japanese participants with rrms.


Eligibility criteria:
key inclusion criteria: * must have had a diagnosis of rrms, as defined by the revised 2017 mcdonald's criteria. all other possible neurologic diagnoses must have been reasonably excluded by means of laboratory and/or imaging studies, in the opinion of the investigator. * must have had an edss score between 0.0 and 5.5, inclusive. * must have had screening mri or documentation of an mri within the participant's medical record within 12 months of the screening visit that revealed 3 or more t2 hyperintense lesions consistent with ms. * was born in japan, and biological parents and grandparents were of japanese origin. key exclusion criteria: * evidence of current severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection within 14 days prior to screening, between screening and baseline visit, or at baseline visit, including but not limited to a fever (temperature \> 37.5 degrees celsius \[°c\]), new and persistent cough, breathlessness, or loss of taste and/or smell. * have close contact within 14 days prior to day 1 with a sars-cov-2 positive individual. * diagnosis of primary progressive ms or secondary progressive ms. * an ms exacerbation (relapse) within 30 days prior to enrolment or, in the opinion of the investigator, the participant not having stabilized from a previous relapse prior to enrolment (day 1). * the participant is unable to have a brain mri scan (e.g., a participant with a metal clip to repair a cerebral aneurysm). * previous exposure to natalizumab. note: other protocol specified inclusion/exclusion criteria may apply.