Kornimate/medical-research-clean huggingface dataset:
oxytocin intranasal administrations in children with prader-willi syndrome aged from 3 to 12 years

Conditions: Prader-Willi Syndrome

Summary: positive results in preclinical and clinical studies in adults and infants with prader-willi syndrome lead investigators to set up a new study in children with prader-willi syndrome. the objective of this study is to document effects of oxytocin intranasal administrations on behavioural troubles in children with prader-willi syndrome aged from 3 to 12 years.

two groups of patients will be constituted according to their age; "group 1" children aged from 3 to 6 years (n = 20) and "group 2" children aged from 7 to 12 years (n = 20). within each group, subjects will be randomized to receive either oxytocin or placebo for 12 consecutive weeks. a second period of 12 consecutive oxytocin treatment weeks will then be performed for all patients, followed by a 4-week observation period to document effects after discontinuation of treatment.

Eligibility criteria:
inclusion criteria: * patient with a complete genetic diagnosis of prader-willi syndrome * patient treated by growth hormone for at least 1 year * patient naïve for oxytocin for at least 5 years exclusion criteria: * patient who do not accept intranasal administrations (major behavioural trouble) * patient with hepatic insufficiency : serum transaminases (sgot, sgpt) higher than 3 times normal values for age * patient with renal insufficiency : serum creatinine higher than 3 times normal values for age * patient with an antecedent of abnormal electrocardiogram * patient with arterial hypertension or hypotension * patient with type 1 or 2 diabetes

Keywords: prader-willi syndrome oxytocin behavioural troubles
the effect and mechanism of lncrna nbr2 regulating endothelial pyroptosis by targeting gsdmd in sepsis

Conditions: Sepsis

Summary: sepsis is a life-threatening disease characterized by multi-organ failure due to dysregulated host response to infection, with high global mortality of 30-50%. one of the most important pathophysiologic hallmarks in sepsis is vascular endothelial injury that contributes to the severity and outcome of the syndrome. effective treatments for endothelial cell injury in sepsis have been lacking to improve prognosis. endothelial pyroptosis is a vital mechanism of vascular endothelial injury in sepsis; mitigation or abolishment of endothelial cell pyroptosis alleviate vascular endothelial damage and improve the prognosis of sepsis mice. gasdermin d (gsdmd) mediated endothelial pyroptosis plays a critical role in modulating vascular endothelial injury in sepsis. long non-coding rna (lncrna), as a class of non-coding protein rna longer than 200 kd, contributes to a variety of cell biological processes. the dysregulation of lncrna results in the occurrence and development of tumors, diabetes, sepsis and other diseases. therefore, we detected lncrna and mrna expression profile in 26 blood samples of septic patients using arraystar lncrna microarray. we found lncrna nbr2 regulates septic endothelial pyroptosis. to assess any correlation of pyroptosis levels with relevant endothelial cell injury parameters and determine the prognostic value in septic patients. we measured the levels of pyroptosis in patients admitted to the department of critical care medicine for sepsis and investigated the correlation with related markers of endothelium injury. furthermore, we determined the prognostic value of pyroptosis levels for the mortality of patients with sepsis.

we measured the levels of pyroptosis in patients admitted to the department of critical care medicine for sepsis and investigated the correlation with related markers of endothelium injury. furthermore, we determined the prognostic value of pyroptosis levels for the mortality of patients with sepsis.

Eligibility criteria:
inclusion criteria: * suspected or confirmed infection * the sequential organ failure score (sofa score) increases by more than or equal to 2 points on the basis * sign the informed consent exclusion criteria: 1. the age \ 80 years of age 2. pregnant 3. tumor 4. viral hepatitis or liver cirrhosis 5. chronic renal tubular nephritis, chronic renal insufficiency 6. ulcerative colitis or crohn's disease 7. active systemic lupus erythematosus (sle) 8. acute myocardial infarction 9. acute pancreatitis 10. engaged in other clinical subjects

Keywords: endothelial cell injury pyroptosis lncrna nbr2 gasdermin d
combination study of s-555739/cetirizine hcl in adult patients with seasonal allergic rhinitis

Conditions: Seasonal Allergic Rhinitis

Summary: the primary objective of the study was to examine the efficacy and safety of s-555739/cetirizine hcl compared with the individual components and placebo.


Eligibility criteria:
inclusion criteria: * history and diagnosis of seasonal allergic rhinitis by skin prick test * have nasal symptom scores as defined by the study protocol * able to comply with study procedures exclusion criteria: * any nasal disease or abnormality, active respiratory tract infections within the past 2 weeks, or recent nasal surgery or sinus surgery at screening * use of any prohibited concomitant drugs or therapies

Keywords: agents, anti allergic nasal congestion sneezing nasal discharge d prostanoid (dp) receptor antagonist
application and evaluation of transference focused psychotherapy modified for adolescents

Conditions: Identity Pathology; Behavior Problems

Summary: normal adolescence requires a successful resolution of identity crisis, which results in the development of satisfying relationships, success in school/work pursuits, and achievement of personal goals. adolescents, who do not resolve this crisis, are at high risk for problems in those areas of functioning. transference focused psychotherapy for adolescents (tfp-a) is a treatment that specifically addresses these issues, permitting adolescents to develop satisfying friendships, more appropriate interactions with authority, and achieve realistic life goals. this study will evaluate the application of tfp-a, (a empirically validated treatment for adults with identity disturbance), to adolescents exhibiting the same behavioral and identity pathology. subjects will be females; ages 14-21, with behaviors associated with identity problems, interpersonal difficulties with teachers, parents and/or peers, and live with their families. these adolescents will be randomly assigned to one of two treatment cells, tfp-a or treatment as usual (tau). subjects in tfp-a will receive weekly individual therapy for six months. the tau group will receive standard individual therapy in the outpatient department. both will receive medication as necessary. all subjects will participate in initial, weekly, and bi-monthly assessments during the six-month treatment period, and participate in a naturalistic follow-up study for an additional six months. hypothesis: adolescents with identity problems as seen in interpersonal, school, and/or family difficulties in the transference focused psychotherapy for adolescents (tfp-a) group will reduce these problem behaviors and improve management of their feelings and moods compared to adolescents with identity problems in the treatment as usual control group (tau).


Eligibility criteria:
inclusion criteria: 1. female adolescents, ages 14-21 2. a score of five out of nine critical items on the borderline personality disorder dimension interview scale. 3. have interpersonal difficulties in school, family, and/or peer functioning. 4. live at home with family. 5. willingness to attend evaluation sessions and weekly, individual therapy. exclusion criteria: 1. the presence of psychosis, substance dependence, non-verbal learning disability, antisocial behavior, and/or primary diagnoses of eating disorder, bipolar disorder, and obsessive-compulsive disorder. 2. the need for hospitalization for symptom management. 3. significant cognitive impairment (full scale iq \<85). 4. the presence of a life-threatening medical illness.

Keywords: identity difussion adolescent psychotherapy transference focused psychotherapy for adolescents identity identity crisis identity pathology
effects of anxiety on coronary microcirculatory function in hypertensive patients

Conditions: Coronary Microvascular Disease; Anxiety State

Summary: this study assessed anxiety status and coronary flow reserve in hypertensive patients to investigate the effects of anxiety on coronary microcirculatory function.

this study assessed anxiety status and coronary flow reserve in hypertensive patients to investigate the effects of anxiety on coronary microcirculatory function.the hypertensive patients with chest pain for suspicious coronary heart disease were seriesly enrolled. all the patients underwent coronary angiography or coronary ct angiography to exclude the diagnosis of obstructive coronary artery disease . coronary flow reserve (cfr) is an integrated measure of flow through both the large epicardial arteries and the coronary microcirculation. in the absence of obstructive stenosis of the epicardial arteries, cfr is an indicator of coronary microcirculatory function，which can be assayed by transthoracic doppler echocardiography. the symptoms of anxiety were measured with self-rating anxiety scale (sas) . according to the sas score,the patients were divided into anxiety group and non-anxiety group.we assessed the association of anxiety with coronary microcirculatory function.

Eligibility criteria:
inclusion criteria: 1. patients with clear diagnosis of hypertension (≥1 year, drug control within 140/90mmhg); (2) significant coronary artery stenosis was excluded by imaging within 1 year (≤50%); (3) age between 18 and 80. exclusion criteria: 1. chd, heart valve disease, congenital heart disease, cardiomyopathy and pericardial disease; (2) left ventricular ejection fraction (lvef) \<50%; (3) increased markers of myocardial injury; (4) diabetes mellitus, connective tissue disease, chronic obstructive pulmonary disease and malignant tumor; 5) severe hepatic and renal impairment (cr ≥120 umol/l, alt ≥120 umol/l); 6) pregnant women.

Keywords: anxiety coronary microcirculatory function hypertension
effect of ambulatory bp monitoring on the clinical course and renal outcome of ckd

Conditions: Chronic Kidney Diseases; Renal Insufficiency, Chronic; Albuminuria; Hypertension

Summary: control of blood pressure (bp) is the first thing to do in the management of chronic kidney disease (ckd). although guidelines suggest the optimal blood pressure level, it is hard to assess bp correctly during the office visit. often there is a discrepancy between office bp and out-of-office bp, including home bp and ambulatory bp. recent study reported that as many as 34% of korean ckd patients had masked hypertension, which means high bp by ambulatory bp monitoring but normal bp by conventional office bp measurement. this study aims to evaluate the effect of ambulatory bp-guided bp management on the clinical outcome of ckd, compared to the conventional management using office bp.

we hypothesized that management of blood pressure using ambulatory bp monitoring would obtain more optimal bp control and thereby would influence positively on renal progression and cv outcomes. in detail, when the eligibility criteria is met, all the subjects will undergo both ambulatory bp and office bp measurement at baseline. after randomization, arb (fimasartan) will be administered to drug-naive subjects or will replace the other ras blockers in subjects with current uses. dosing of fimasartan will be adjusted or additional drugs of other classes will be added sequentially over 3 months (titration phase). at 3 months, abpm will be performed in abpm group to evaluate the adequacy of blood pressure control and dosing will be adjusted according to the abpm results (target bp: daytime bp \< 135/85 mm hg). this adjustment will be assessed at 6 months by abpm once again. for subjects in office bp group, conventional care will be provided according to current guidelines (target bp \< 140/90 mm hg). at 18 months, abpm will be performed in all the subjects and outcome measures will be assessed.

Eligibility criteria:
inclusion criteria: * office bp \> 130/80 mm hg, irrespective of anti-hypertensive medication * ckd stages 3-4 (or estimated gfr 15-59 ml/min per 1.73 m2) * random urine albumin-to-creatinine ratio \> 300 mg/g or protein-to-creatinine ration \> 300 mg/g or dipstick albumin \> 1+, in case of estimated gfr 45-59 ml/min per 1.73 m2 exclusion criteria: * systolic bp \> 180 mm hg or diastolic bp \> 110 mm hg * malignant hypertension * resistant hypertension (using more than three kind of anti-hypertensive drugs other than diuretics) * uncontrolled dm (hb a1c \> 10.0% within 3 months of eligibility assessment) * use of immunosuppressive agents within 1 months or anticipated * atrial fibrillation or flutter * contraindication to renin-angiotensin system blockers (hypersensitivity, bilateral renal artery stenosis, single kidney, etc.) * pregnancy * kidney recipients * participating other clinical trials, except observational studies

Keywords: chronic kidney disease blood pressure ambulatory blood pressure glomerular filtration rate
anal fistula plug versus endorectal advancement flap

Conditions: Anal Fistula

Summary: the purpose of this study is to determine whether anal fistula plug or endorectal advancement flap is more successful in the treatment of anal fistulas and compared both procedures with regards to cost.

a detailed analysis will be performed to determine independent predicting factors of recurrence and of higher costs.

Eligibility criteria:
inclusion criteria: * adults (18 years of age or more) * single anal fistula * surgically treated with anal fistula plug or endorectal advancement flap exclusion criteria: * children or adolescents * pregnancy * patients treated with setons alone

Keywords: fistula in ano anal fistula recurrence costs
assessment, feedback, incentive, exchange (afix ob) a customizable quality improvement intervention to increase maternal vaccine uptake

Conditions: Influenza; Whooping Cough

Summary: the purpose of this study is to evaluate the afix-ob model to determine its impact on the change in flu and pertussis (tdap) uptake, provider knowledge, attitudes and beliefs, and patient knowledge, attitudes and beliefs regarding maternal vaccination. the structure of the model and quality improvement interventions are guided by theory including the elaboration likelihood model and p3 model. these quality improvement measures will be implemented in ob clinics within the yale new haven health system.


Eligibility criteria:
inclusion criteria: * between 18-50 years of age * currently pregnant and gestational age \<26 weeks exclusion criteria: * already enrolled in the study

Keywords: pregnancy vaccination vaccine acceptance influenza pertussis tdap
mk0429 study in prostate cancer patients with metastatic bone disease (0429-011)

Conditions: Prostatic Neoplasms

Summary: this two part study will evaluate the safety and tolerability of mk0429 in addition to assessing it's pharmacokinetic profile and pharmacodynamic response.


Eligibility criteria:
inclusion criteria: * eligible patients must have: * prostate cancer * bone metastases without symptoms * lack of response to hormone therapy as evidenced by a rising psa or clinical progression exclusion criteria: * prostate cancer-related bone pain * previously received bisphosphonate therapy (e.g. zoledronate) * received any investigational treatment within the last 30 days
physical therapy for diabetes mellitus

Conditions: Diabetes Mellitus

Summary: background: the aim of this study to compare the effect of moderate exercises versus light exercises on patients with type 2 diabetes mellitus. methods: this 3-month, 2-arm cluster randomized controlled trial involved 60 patients aged between 35and 60 years divided randomly into two groups. group 1 received 30 minutes of aerobic exercise at 40-60% of maximum heart rate. group 2,treated by walking30 minutes daily divided into 5minutes every 2 hours to break sedentary position for 12 hours daily. results: at the base line no significant difference were found in both groups in all parameters. after three months of treatment, there is no significant difference in all parameters bmi, p=0.111, waist to hip ratio, p=0.245, 6 minutes' walk, p=0.614, blood glucose, p=0.105 and sf-36, p=0.106. the study approved by ethical committee of faculty of physical therapy, cairo university rec/012/002607. conclusion: light exercise has the same effect on blood glucose as moderate exercise, so just walking for 5 minutes every 2 hours can be useful for patients with type 2 diabetes mellitus.

78 patients have been chosen from department of internal medicine, cairo university hospitals, egypt. 8 patients were excluded because 3 have chronic renal failure, 3 have cardiopulmonary diseases and 2 have severe osteoarthritis of knees. they were divided randomly into two groups, group one will be treated by moderate exercises and group and group 2 will be treated by light exercises. after division all the procedures were explained to patients.5 patients refused to sign informed consent and excluded from the study.33 patients in group1 and 32 patients in group2.3patients dropped in group1 and excluded from the study and two patients didn't continued the programmed treatment in group 2 and their data removed. thirty patients in each group signed an informed consent and complete the treatment program.

Eligibility criteria:
inclusion criteria: * type2 diabetes mellitus. * age between 35 and 60. * bmi≥30 exclusion criteria: * renal failure. * cardiopulmonary diseases. * lower limb diseases or fracture.

Keywords: moderate exercises light exercises obesity sedentary behavior
proteomic analysis in sera from patients with erosive hand osteoarthritis

Conditions: Erosive Hand Osteoarthritis

Summary: hand osteoarthritis is a common phenotype of osteoarthritis which affects about 70 % of the elderly population. usually considered as a minor illness, it nevertheless leads to an important functional impairment. the mechanism of this disease is still poorly known. furthermore there are 2 different subtypes : erosive and non erosive hand osteoarthritis from which mechanisms may differ. methods: this is a cross-sectional study recruiting patients with hand osteoarthritis addressed in consultation of rheumatology and plastic surgery in rouen university hospital. two groups of patients will be studied: 20 patients with non erosive subtype of hand osteoarthritis and 20 patients with erosive subtype of hand osteoarthritis. a clinical evaluation of hand osteoarthritis will be performed. blood sample for proteomic analysis will be taken. hand mri and bone mineral analyser will be performed.


Eligibility criteria:
inclusion criteria: * female gender * less than 70 years old * diagnosis of hand osteoarthritis according to acr criteria acr after exclusion of thumb base osteoarthritis: 1. hand pain, aching or stiffness most of the days during the preceding month 2. hard tissue enlargement of at least two of 8 selected joints \* 3. hard tissue enlargement of at least two distal interphalangeal joint 4. swelling of fewer than three metacarpophalangeal joint 5. deformity of at least one of 10 selected joints \* patients have to fulfil criteria 1, 2 and 3 + 4 or 5 \* the 8 selected joints are the second and third distal interphalangeal joint and the second and third proximal interphalangeal of both hands then confirm by experts' committee * exclusively symptomatic treatment * for women of child-bearing age, use of an effective contraceptive method * french spoken and read exclusion criteria: * male gender * more than 70 years old * hemochromatosis * inflammatory arthritis * cristal induced arthritis * active diseases such as infection or cancer * use of dmards * pregnant or breast-feeding woman
diet and exercise on ambulatory blood pressure

Conditions: Prehypertension

Summary: this is a multicenter, randomized, single-blinded clinical trial investigating the effect of dietary management and active aerobic exercise training on reduction of 24-hour ambulatory blood pressure in subjects with prehypertension and drug-naïve stage 1 hypertension.

most guidelines recommend lifestyle modifications such as exercise or dietary programs for stage 1 hypertension or prehypertension, before initiation of antihypertensive drug treatment. epidemiological and observational studies have shown that cardiovascular risk increases progressively from blood pressure levels as low as 115/75 mmhg and that patients with prehypertension or stage 1 hypertension are likely to progress to hypertension requiring medications. from a previous clinical trial, a 12-week aerobic exercise program reduced 24-hour and daytime ambulatory blood pressure in patients with resistant hypertension. aerobic exercise and dash (dietary approaches to stop hypertension) diet are currently recommended in subjects with prehypertension and stage 1 hypertension without a clear randomized, controlled clinical trial. the present trial, thus, seeks to evaluate the effect of dietary management and active aerobic exercise training, preferably moderate-intensity exercise, on 24-hour ambulatory blood pressure.

Eligibility criteria:
inclusion criteria: * age 18-80 years * prehypertension or grade 1 hypertension, defined as a systolic blood pressure of 130 to 159 mm hg and/or a diastolic blood pressure of 85 to 99 mm hg * patients without previous use of anti-hypertensive medication exclusion criteria: * patients under anti-hypertensive medications * patients with suspected or confirmed secondary hypertension * patients with abnormal liver function tests (transaminases more than three times the upper limit of normal) * patients without aerobic exercise tolerance * patients under hormone replacement therapy or other steroids * patients with peripheral edemas and/or baseline serum creatinine level above 2.0 mg/dl * patients with medical conditions that potentially affect blood pressure, including neurological disorders, gastrointestinal diseases, or malignancy.

Keywords: prehypertension aerobic exercise dietary management