Kornimate/medical-research-clean huggingface dataset:
the biological basis of phlegm dampness syndrome in patients with ischemic stroke：a saliva and urine proteomics study

Conditions: Protein; Disease

Summary: this study aimed to explorie the biological basis of phlegm-dampness syndrome in patients with ischemic stroke using proteomics research techniques of urine and saliva.

stroke is the disease with the highest mortality and disability in china, and the annual incidence of ischemic stroke is the highest. atherosclerosis is the main cause of ischemic stroke. according to the theory of traditional chinese medicine, the disease is closely related to the physical constitution of the individual. the main body constitution of the population in lingnan area is phlegm dampness syndrome;previous large cross-sectional studies have found that 65.3% of patients with ischemic stroke in lingnan area have phlegm dampness syndrome. however, there is currently no biological evidence related to phlegm-dampness syndrome and ischemic stroke.in recent years, proteomics research technology has developed vigorously. the research samples have developed from blood obtained from minimally invasive to urine and saliva obtained non-invasively. studies have found that urine proteins associated with as include type i, type iii collagen, 8-isoprostaglandin f2α, and saliva proteins include il-1β, il-6, tnf-α, and pge2.therefore, this research is dedicated to exploring the biological basis of phlegm-dampness syndrome in patients with ischemic stroke using proteomics research techniques of urine and saliva.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of ischemic stroke 2. aged 35-80-year-old. 3. agree to participate in clinical research and sign informed consent. exclusion criteria: 1. clinical diagnosis of cerebral hemorrhage; 2. with severe infection, severe renal dysfunction, and tumor; 3. clinical diagnosis of acute oral inflammation, oral ulcers, or urinary infections; 4. clinical diagnosis of systemic lupus erythematosus and rheumatoid arthritis; 5. pregnant women or lactating mothers

Keywords: ischemic stroke phlegm dampness syndrome traditional chinese medicine proteomic
sphenopalatine ganglion block study

Conditions: Sphenopalatine Ganglion Nerve Block

Summary: the goal of this clinical trial is to compare the administration and dosage of bupivacaine for sphenopalatine ganglion (spg) nerve block. the main question\[s\] it aims to answer are: * does a high dose (3ml) give more relief than a low dose (1ml)? * does bilateral administration give more relief than unilateral? participants with headaches will be asked to lie down and have spg block performed. researchers will compare dosage and administration to see how symptoms are reduced.


Eligibility criteria:
inclusion criteria: * present to ed for management of headache * headache is moderate or severe in intensity exclusion criteria: * allergy to bupivacaine * nasal or sinus surgery

Keywords: sphenopalatine ganglion nerve peripheral nerve block headache migraine
is there a genetic predisposition for acute stress-induced (takotsubo) cardiomyopathy

Conditions: Takotsubo Cardiomyopathy

Summary: acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. in the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. this could also have implications for their families.

acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. the researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. the investigators will also archive dna for identification of future candidate genetic variants. ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.

Eligibility criteria:
inclusion criteria: * all patients who have been diagnosed with takotsubo cardiomyopathy in scotland between 2010 to date. * familial cases elsewhere in the world who would be willing to participate. exclusion criteria: * unwillingness to participate
quantitative cardiac parametric mapping

Conditions: Cardiomyopathy, Myocarditis, Ischemic Heart Disease

Summary: the overall goal of this project is to evaluate the clinical potential of fast quantitative myocardial tissue characterization using recently emerged cardiac magnetic resonance imaging (cmr) techniques to aid the diagnosis, treatment, and follow up of patients with myocardial diseases, such as ischemic heart disease, cardiomyopathies, and myocarditis.


Eligibility criteria:
inclusion criteria: * subject must be 18-90 years of age. * subject must be previously diagnosed with or suspected to have one of the following conditions. * myocardial ischemia or infarction (group 1) * hypertrophic cardiomyopathy (group 2) * infiltrative cardiomyopathy (group 3) * myocarditis (group 4) * subject must have been referred for a clinically indicated cmr. exclusion criteria: * subject has any implanted device or condition in which an mr scan would be contraindicated. * subject has an acute psychiatric disorder or is cognitively impaired. * subject is using or is dependent on substances of abuse. * subject is unwilling to comply with the requirements of the protocol. * subject has previously entered this study. * subject has an allergy against mri contrast agents. * subject is in acute unstable condition.

Keywords: myocardial tissue characterization
cost-effectiveness analysis of a virtual reality-assisted hypnotherapy program on quality of life in patients with chronic low back pain: a multicenter, randomized, prospective, comparative, open-label, parallel-group study

Conditions: Chronic Pain; Low Back Pain; Chronic Low Back Pain (CLBP)

Summary: this randomized, prospective study aims to evaluate the effectiveness and cost-efficiency of a virtual reality (vr)-assisted hypnotherapy program on quality of life in patients with chronic low back pain. the study compares a vr-assisted hypnotherapy group to a standard treatment group. both groups will undergo a conventional physical therapy program supervised by physiotherapists for 3 weeks (15 sessions). the vr-assisted hypnotherapy group will receive additional sessions utilizing the hypnovr software, which delivers relaxing virtual environments. outcomes will be assessed immediately after treatment, at 1 month, and at 3 months post-treatment. primary endpoints include pain reduction measured by the visual analog scale (vas). secondary endpoints include functionality, quality of life, anxiety, depression, sleep quality, healthcare costs, and treatment adherence. statistical analyses will determine the efficacy and economic impact of this innovative therapy for chronic low back pain management.


Eligibility criteria:
inclusion criteria: * age between 50 and 80 years. * chronic neck pain lasting for more than 3 month exclusion criteria: * presence of newly developed neurological deficits. * existence of comorbid neurological diseases. * medical history unsuitable for the use of virtual reality (vr) glasses (e.g., visual impairment, epilepsy). * pregnancy. * changes in medication for chronic pain management within the last three months (e.g., pregabalin, gabapentin, duloxetine, etc.).

Keywords: hypnotherapy virtual reality
reduced dose radiotherapy following high dose chemotherapy in intracranial non-germinomatous germ cell tumor

Conditions: Intracranial Non-germinomatous Germ Cell Tumor

Summary: the purpose of this study is to evaluate the outcome of intracranial non-germinomatous germ cell tumor (nggct) treated with reduced radiotherapy following high dose chemotherapy and autologous stem cell transplantation (hdct/auto-sct).

treatment outcome of intracranial nggct is around 50% with conventional chemo- and radiotherapy. also, late sequelae such as endocrinopathy or cognitive problem are unavoidable especially with craniospinal irradiation. in this study, high dose chemotherapy and reduced dose of radiotherapy will be used to improve survival and minimize the late sequelae in the patients with intracranial nggct.

Eligibility criteria:
inclusion criteria: * patients with pathologically proven intracranial non-germinomatous germ cell tumor or * patients who have brain mass which are suspected as intracranial germ cell tumor and elevated serum or cerebrospinal fluid alpha-feto protein. exclusion criteria: * patients with organ dysfunction (ejection fraction \ 3 x upper limit of normal (uln), aspartate aminotransferase/alanine aminotransaminase \> 5 x uln). * pregnant or nursing women
comparing postoperative pain after vessel sealing device versus conventional suturing methods for vaginal hysterectomy and pelvic reconstructive surgery

Conditions: Pelvic Organ Prolapse

Summary: this study will investigate pain outcomes for patients undergoing vaginal hysterectomy with pelvic reconstructive surgery using the ligasuretm vessel sealing device as compared to conventional clamping and suturing methods.


Eligibility criteria:
inclusion criteria: * english speaking, able to understand informed consent * vaginal hysterectomy with vaginal vault suspension * with or without anterior and posterior repairs * with or without removal of fallopian tubes or ovaries * with or without procedures for stress urinary incontinence exclusion criteria: * use of mesh for prolapse repair * robotic, laparoscopic, or open technique used for prolapse repair and/or hysterectomy * concomitant procedure done by an additional surgeon * concomitant anal sphincteroplasty or rectovaginal fistula repair * history of chronic pelvic pain receiving medical care * daily use of medication for pain: nsaid, tylenol, opioid, gabapentin, and/or amitriptyline * pregnancy

Keywords: pelvic organ prolapse vaginal hysterectomy vaginal vault suspension prolapse repair
intervention to address psychosocial needs among socially disadvantaged older adults with cancer

Conditions: Hematological Disorder

Summary: the purpose of this study is to convene a group of diverse north carolina-based community representatives (patients, caregivers, leaders of faith-based organizations, social workers, and patient navigators) to inform the adaptation of materials used to train lay navigators in the delivery of psychosocial support interventions tailored to older socially disadvantaged adults with cancer.

this behavioral study will explore community representatives' perspectives on the resources and training needed to support the development of a lay navigation program tailored to older socially disadvantaged adults with cancer. it was hypothesized that diverse community representatives could inform the adaptation of training materials (peer connect) and subsequent training of community lay navigators, who will then be positioned to address the psychosocial needs of older adults with cancer

Eligibility criteria:
inclusion criteria to participate in the study: 1. patients aged 65 and older diagnosed with hematological cancer for at least one year with stable disease 2. community representative 18 years or older who also identifies as at least one of the following: 1. cancer caregivers 2. social workers, social work students, or patient navigators community leader (e.g., leader of a faith-based organization) 3. previously or currently serve as a lay navigator/peer supporter, community health worker, or coach 4. have personal experience with any of the following (being black race, previously or currently facing socioeconomic challenges, or living in a rural community) 5. patient or community representative who is able to understand and speak in english exclusion criteria all participants meeting any of the following exclusion criteria at enrollment will be excluded from the study: 1. inability to read and speak english 2. dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent exclusion criteria all participants meeting any of the following exclusion criteria at enrollment will be excluded from the study: 1. inability to read and speak english 2. dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent

Keywords: socially disadvantaged older psychosocial need
association of frailty and delirium in elderly hip fracture patients

Conditions: Delirium in Old Age; Frailty

Summary: several studies have shown that frailty can be used as a marker for risk of adverse outcomes in elderly patients such as falls, disability, hospitalization, mortality, and can be used to predict patient clinical outcomes. the purpose of this study is to determine whether preoperative frailty can be used as a diagnostic and predictive factor for postoperative delirium in elderly patients with hip fracture.

frailty index (fi) is a reliable method to determine the assessment of frailty in elderly patients. multiple prospective cohort studies have shown that frailty can be used as a marker for risk of adverse outcomes in older adults such as falls, disability, hospitalization, and mortality, and can be used to predict patient clinical outcomes. whether frailty could be used as a diagnostic and predictive factor for delirium is urgently needed in a large population. therefore, this project intends to conduct a prospective cohort study. patients will be divided into three groups according to frailty index (fi) before surgery, and delirium status will be evaluated by using scales after surgery, so as to explore the diagnostic and predictive value of frailty on pod. once confirmed, the results of this study will be helpful for the early identification, screening, diagnosis and evaluation of treatment effect of pod. it is of great scientific significance and social benefit to reduce the incidence of pod, improve the prognosis of vulnerable patients and reduce the burden of disease.

Eligibility criteria:
inclusion criteria: * the subjects were patients with hip fracture; * older than 65 years; * patients signed informed consent; * american society of anesthesiologist (asa) rated i- iii; * the surgery was performed by the same anesthesia and surgical team. exclusion criteria: * patients cannot sign the consent form or refuse to participate; * a history of cognitive impairment; * unable to complete the cognitive function test; * mental disorder during initial assessment; * patients suffering from mental illness or substance use disorder; * incomplete or lost data during follow-up.

Keywords: frailty postoperative delirium hip fracture elderly
improving nighttime access to care and treatment (part 2)

Conditions: Acute Diarrhea; Acute Respiratory Infection; Acute Febrile Illness

Summary: children in resource-limited settings who develop illness at night are often isolated from pre-emergency care, resulting in progression to an emergency because families are forced to wait until morning to seek care. this is especially true in haiti based on needs assessments (inact part 1; inact1) surrounding access to healthcare. this study (inact part 2; inact2) seeks to improve access to care by establishing a health hotline (healthline) and mobile pharmacy for families with children who become ill at nighttime. the healthline will be staffed by medical professionals and will provide phone based assessment and treatment recommendations based on standard of care practices according to haitian and who guidelines. the healthline will focus on pre-emergency patients (those without danger signs as defined by who guidelines). emergent patients will be advised to bypass the healthline and seek immediate care at the nearest medical facility. in the event that a non-emergent patient requires access to basic medications or fluids and is logistically accessible, the mobile pharmacy service will be offered. the specific aims of the study are as follows: aim i. evaluate congruence between healthline assessment over the phone and in-person assessment of participants (patients using the healthline) 10 years of age and younger. the investigators hypothesize that in-person assessments based on who guidelines will be discordant with those made by the healthline because the physical aspects of the call-center assessment will be performed by an untrained parent/ guardian. the study focuses on acute diarrheal disease (add) and acute respiratory illness (ari) but is not exclusive to these two chief complaints. aim ii: identify determinants that correlate with seeking care at a medical facility over the 8-12 day follow up period after the initial call. the findings from this study will determine if a healthline model is a safe and accurate method of providing high quality access to nighttime healthcare, averting the progression of non-emergent cases to emergencies.


Eligibility criteria:
inclusion criteria: * age of patient must be 10 years or younger * patient must reside inside the study delivery area * consent/assent to participate exclusion criteria: * emergent illness (danger signs present)

Keywords: telemedicine diarrhea diarrhoea mhealth healthline
improvement effect of lacosamide and levetiracetam on cognitive in alzheimer's disease patients with epilepsy

Conditions: Alzheimer Disease 3; Epilepsy

Summary: participants will perform mini-mental state examination (mmse), montreal cognitive assessment (moca), clinical dementia rating (cdr), alzheimer's disease assessment scale-cognitive section (adas-cog), hamilton anxiety scale (hama) and hamilton depression rating scale (hamd) evaluation. the patients will be randomly divided into two groups, treated with lacosamide and levetiracetam respectively, and maintained for 6 months. researchers will compare the lacosamide group with the levetiracetam group to see if the improvement of cognitive function in the two groups.


Eligibility criteria:
inclusion criteria: * clinically diagnosed as alzheimer's disease and treated with cholinesterase inhibitors; * new seizures or subclinical epileptic discharges; * mini-mental state examination score ≥ 18 points, and/or clinical dementia rating (cdr) score \< 2 points; * sign the informed consent form. exclusion criteria: * suffering from syncope, transient ischemic attack, hysteria attack, migraine and other transient brain dysfunction; * serious medical disease (especially atrioventricular block) or mental illness; * there are structural abnormalities related to epilepsy in other brain regions of imaging

Keywords: alzheimer disease epilepsy lacosamide levetiracetam
observational study with metronomic oral vinorelbine in elderly patients with locally advanced / metastatic non-small-cell lung cancer (nsclc)

Conditions: Locally Advanced/ Metastatic NSCLC

Summary: vinorelbine is the first line reference drug in the elderly patient with locally advanced / metastatic non-small-cell lung cancer (nsclc). the introduction of the oral formulation of vinorelbine has determined a further impulse to its use in 1st line and above all to its use as "metronomic" therapy. metronomic chemotherapy offers the advantage of increasing the overall dosage of the drug administered, but reducing the side effects or making them more easily manageable; it is practically a question of administering fractionated doses of the drug continuously for long periods (generally up to the progression of unacceptable disease or toxicity). this study collects data on the efficacy and tolerability of oral metronomic vinorelbine in elderly patients with nsclc, performed as per normal clinical practice.

vinorelbine is the first line reference drug in the elderly patient with locally advanced / metastatic non-small-cell lung cancer (nsclc). the introduction of the oral formulation of vinorelbine has determined a further impulse to its use in 1st line and above all to its use as "metronomic" therapy. metronomic chemotherapy offers the advantage of increasing the overall dosage of the drug administered, but reducing the side effects or making them more easily manageable; it is practically a question of administering fractionated doses of the drug continuously for long periods (generally up to the progression of unacceptable disease or toxicity). this study collects data on the efficacy and tolerability of oral metronomic vinorelbine in elderly patients with nsclc, performed as per normal clinical practice.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of histologically documented nsclc (adenocarcinoma and squamous carcinoma), stage iiib (not eligible for surgery or chemo-radiotherapy) and stage iv according to the 8th edition of tnm * "wild type" for egfr, alk and pdl-1 * age ≥ 70 years * ps 0 - 2 * adequate medullary reserve (neutrophils\> 1500; plt\> 100,000 mm3); hepatic / renal function preserved * written informed consent exclusion criteria: * gastrointestinal disorders that contraindicate the intake of the capsules (type ulcerative colitis or chron's disease). * performance status ecog ≥ 3
transcranial direct current stimulation for depression

Conditions: Depressive Disorder

Summary: several studies have shown that tdcs is valuable and safe options to improve depressive symptoms in adult patients . however, regarding the tdcs to treat depression in elderly population, only few studies have been reported, and there is no consensus among them. to our knowledge, prefrontal cortex tdcs could be reasonably safe and efficient options for the treatment of several psychiatric illnesses in a population presenting resistance to and/or intolerance of pharmacotherapy . moreover, the safety tolerability profile of tdcs is a strong argument in favour of exploring their use in the depressed population. therefore, current study will investigate the efficacy and safety of prefrontal tdcs used as additive treatment in patients with lld.


Eligibility criteria:
inclusion criteria: 1. participants who meet the criteria of major depression defined by dsm-5 criteria 2. participants will be non-responders and taking an antidepressant of adequate dose and for ≥4 weeks in the current episode which has not led to sufficient clinical improvement (defined as a minimum level of 2 on the athf); or can't tolerate the adverse effects of antidepressant in the current episode 3. ambulatory participants with or without any aiding device exclusion criteria: 1. an urgent risk of suicide or severe depression 2. a history of ineffectiveness with tdcs 3. people who are clinically contraindicated to receive tdcs intervention or mri assessment, such as having any brain lesion, intracranial implants (clips, cochlear implants), a tattoo or metal embedded in their scalp or brain 4. any instable medical condition 5. a history of epilepsy, 6. a history of substance use (within one year) 7. people with dementia or psychotic disorder. 8. any condition which would make the subject unsuitable for the study under the physician's assessment.