Kornimate/medical-research-clean huggingface dataset:
the podium study - a three-arm comparison of target therapies after anti-tnfα in ulcerative colitis

Conditions: Ulcerative Colitis (Disorder)

Summary: the goal of this observational study is to compare the real-life effectiveness and safety of vedolizumab, ustekinumab and jak inhibitors in patients with uc who had been exposed to at least one anti-tnf-alpha therapy.


Eligibility criteria:
inclusion criteria: * established diagnosis of uc according to the current european crohn's and colitis organization (ecco) guidelines7; * age ≥ 18 years-old; * capability of expressing informed consent; * clinically active ulcerative colitis (cf. 'operative clinical measures', below) at baseline; * initiation of vedolizumab, ustekinumab or jak inhibitors (tofacitinib, upadacitinib or filgotinib) as second-line target therapy at baseline; * previous treatment with at least one anti-tnfα drug licenced for the treatment of uc (i.e., infliximab, adalimumab and/or golimumab); * no exposure to vedolizumab, ustekinumab and jak inhibitors before baseline; * at least 1 follow-up visit after baseline exclusion criteria: * diagnosis of crohn's colitis, ibd-u or other gastrointestinal inflammatory conditions; * age \< 18 years-old; * incapability of expressing informed consent; * acute severe uc requiring hospitalization at baseline; * no previous exposure to anti-tnfα therapies; * previous treatment with target therapies other than anti-tnf-α for uc before baseline; * ustekinumab or jak inhibitors induction with a non-standard posology for uc.
the effect of gardening activities on anxiety and psychosocial symptoms of hospitalized children

Conditions: Gardening; Pediatric Nursing; Activity; Psychosocial Symptoms; Anxiety; Hospital; Child; Investigation of Anxiety Levels and Psychosocial Symptoms of Children Hospitalized for Acute Diseases During Their Hospital Stay

Summary: the experience of hospitalization in childhood can often lead to traumatic consequences. various practices (play, art therapy, music therapy, etc.) are used to help children cope with this process. in recent years, attention has been drawn to nature-based approaches in addition to existing practices. within the scope of this approach, this study was planned in a parallel group (experimental-control) randomized controlled experimental design to determine the effect of garden activities on anxiety levels and psychosocial symptoms of hospitalized children aged 6-12 years. hypotheses of the study h1: the gardening activities program applied to hospitalized children; h1a: there is an effect on children's anxiety. h1b: there is an effect on psychosocial symptoms of children. in this direction, the population of the study will consist of children between the ages of 6-12 in the children's ward of university research and application hospital. the sample size determined as a result of g\*power analysis was found as control (18) and intervention (18). the research will be conducted between september 2024 and june 2025. 'child descriptive information form', "child follow-up form", "child anxiety scale-conditioning" and "psychosocial symptoms diagnostic scale for hospitalized children" will be used for data collection. the data collection process consists of three stages: pre-intervention period, intervention period and post-intervention period. children in the intervention group will have three sessions of gardening activities within the scope of the 'gardening activities program' during their hospitalization. children in the control group will receive services within the scope of the routine treatment and nursing care protocol of the clinic during hospitalization.


Eligibility criteria:
inclusion criteria: * the age of the children is between 6-12 years old * hospitalization due to an acute medical diagnosis * hospitalization for at least 3 days * approval of the child's participation in the session by the responsible doctor * the child is conscious and fully orientated * voluntariness of the child and parent to participate in the study exclusion criteria: * hospitalization for more than 7 days * no previous hospitalization experience * high-risk drug use * having a chronic disease that suppresses the immune system * having a special condition that prevents him/her from participating in garden activities (physical, mental disability) * having skin conditions that prevent them from participating in garden activities * plant allergy

Keywords: hospitalized child garden activity pediatric nursing psychosocial symptoms anxiety mobile garden
piloting a novel intuitive eating intervention for college women with disordered eating

Conditions: Disordered Eating Behaviors

Summary: the purpose of this research study is to pilot test a new intervention that helps young adult women learn adaptive eating and exercise strategies, increase their body acceptance, decrease unhealthy weight control behaviors and prevent future eating and problems. this intervention is experimental, and the study will test its feasibility, acceptability, and effectiveness.

the intervention, intuitive eating, is an eating approach that addresses important risk factors and promotes adaptive eating attitudes and behaviors. it has three central tenets: 1) unconditional permission to eat when hungry, 2) eating for physical rather than emotional reasons, and 3) eating according to hunger and satiety cues. intuitive eating has ten principles that focus on rejecting the dieting mentality, honoring hunger cues, decreasing restrictive behaviors that lead to deprivation and bingeing, challenging rigid food rules, increasing awareness of satiety, discovering the satisfaction of food, coping with emotions without food, respecting and accepting one's body, using exercise as self-care, and balancing nutrition with satisfaction.

Eligibility criteria:
inclusion criteria: * not currently pregnant * enrolled in postsecondary education at vcu * have body image or eating concerns exclusion criteria: * eating disorder threshold risk * men * pregnant women

Keywords: disordered eating, body image, intuitive eating, undergraduates, college, unhealthy weight control behaviors, eating disorders, weight stigma, weight bias
changes of higher-order aberrations after different types of lasik in myopia

Conditions: Conventional LASIK, Femto-LASIK and PRK in Low and Moderate Myopia

Summary: this prospective comparative interventional study will enroll patients with low and moderate myopia who seek laser vision correction at sohag center for lasik and corneal surgeries, sohag, egypt. eyes included will be divided into 3 groups according to the type of refractive surgery used (conventional lasik, femto-lasik and prk) and each group will be subdivided into 2 groups according to the degree of myopia (low and moderate).


Eligibility criteria:
inclusion criteria: age: 18 - 45 years old. refraction: low and moderate grades of myopia will be included: (according to manifest refraction) low (\[0\] - ≤ \[-3\] diopters) moderate (\[-3\] - ≤ \[-6\] diopters) with cylinder ≤ \[-1.5\] diopters. exclusion criteria: any ocular surgery or medication, corneal opacities, pregnancy, lactation and keratoconus.
japan unified protocol clinical trial for depressive and anxiety disorders (junp study)

Conditions: Anxiety Disorders; Depressive Disorders

Summary: this study is to examine the superiority of the combined treatments of transdiagnostic cognitive-behavior therapy (unified protocol; up) and treatment-as-usual in comparison with the waiting-list with treatment-as-usual in the reduction of depressive and anxiety symptoms among depressive and anxiety disorders.

participants with depressive or anxiety disorders will be randomized to either unified protocol with treatment-as-usual or wail-list with treatment-as-usual. intervention period will be 20-week and the follow-up period will be 43 week from registration.

Eligibility criteria:
inclusion criteria: * dsm-iv diagnosis of major depressive disorder, dysthymia, depressive disorder not otherwise specified, panic disorder with agoraphobia, panic disorder without agoraphobia, agoraphobia without history of panic disorder, social phobia(social anxiety disorder), obsessive-compulsive disorder, posttraumatic stress disorder, generalized anxiety disorder, anxiety disorder not otherwise specified assessed by scid. * depressive and anxiety symptoms is mild or more severe (grid-hamd \>= 8). * ages 20 years or older, and 65 years or younger at screening. * subjects who give full consent in the participation of the study. exclusion criteria: * no alcohol or substance use disorder in 6 months prior to the screening assessed by scid * no current manic episode or current schizophrenia and other psychotic disorders at baseline assessed by scid * no serious suicidal ideation at baseline (grid-hamd item3 severity is 3 or higher.) * no life-threatening, severe or unstable physical disorders or major cognitive deficits at baseline. * evidence of unable to participate half or more of the intervention phase. * no structured psychotherapy during at baseline. * other relevant reason decided by the investigators.
heart failure-usb: prediction and progression

Conditions: Acute Heart Failure; Acute Coronary Syndrome; Heart Failure

Summary: this retrospective cohort study is to identify triggers of heart failure (hf) development and drivers of hf progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical course of the disease. data of patients who were hospitalized during the years 2010-2023 with acute coronary syndrome (acs) and/ or with acute heart failure (ahf) will be collected and analyzed. in a subgroup cohort efficacy and safety of digoxin in patients with acute heart failure triggered by tachyarrhythmia will be evaluated.


Eligibility criteria:
inclusion criteria: * patients hospitalized with a primary diagnosis of acs * patients hospitalized with a primary or secondary diagnosis of ahf exclusion criteria: * existence of a documented statement of the patient against the scientific use of clinical data
effects of l-arginine and liposomal vitamin c supplementation on physical performance

Conditions: Sarcopenia

Summary: in older age, reduced mobility is associated with an increased risk of reduced quality of life, disability, institutionalisation, and death, as well as increased healthcare expenditures. sarcopenia is a condition characterised by a reduction in muscle mass and strength and/or function. it is associated with several adverse outcomes, such as falls, increased risk of infection, disability, institutionalisation, and death. currently, no pharmacological treatments are available to combat sarcopenia. the management of sarcopenia relies on the adoption of an active lifestyle, comprising resistance exercise, which may be supported by an adequate intake of protein with the diet. recently, treatment with l-arginine and liposomal vitamin c has been shown to significantly reduce fatigue, and improve physical performance and endothelial reactivity in adult patients with long covid. long covid may be considered a model of accelerated ageing, as it recapitulates several age-associated biological processes, including chronic inflammation, oxidative stress, endothelial dysfunction and malnutrition.


Eligibility criteria:
inclusion criteria: * probable sarcopenia defined according to ewgsop2 criteria exclusion criteria: * inability or unwillingness to provide informed consent; * nh residents; * schizophrenia or other psychotic disorders, bipolar syndrome; * consumption of more than 14 alcoholic beverages per week; * reduced cognitive performance (mini-mental state examination score \<26); * severe arthrosis; * malignancies requiring treatment in the previous 3 years; * lung disease requiring chronic corticosteroid therapy or oxygen therapy; * severe cardiovascular disease; * parkinson's disease or other developmental neurological disorders; * renal failure undergoing dialysis treatment; * chest pain, severe dyspnea or conditions that may pose safety concerns when performing the 6-minute test or chair test; * other medical, psychiatric or behavioral factors that, in the judgment of the researcher, may interfere with participation in the study; * other illnesses related to an estimated life expectancy of less than 12 months.

Keywords: aging muscle wasting physical function handgrip nitric oxide
the effect of multidomain dietary education in type 2 diabetic adults

Conditions: Type2 Diabetes Mellitus; Cognitive Impairment, Mild

Summary: the goal of this clinical trial is to \[learn about cognitive stimulation by multidomain dietary education including the dietary board game via line in non-dementic type 2 diabetic adults. the main questions it aims to answer are: \[question 1: could multi-domain dietary education as cognitive stimulation improve cognitive function?\] \[question 2: could multi-domain dietary education improve dietary control belief ?\] \[question 3: could multi-domain dietary education improve health behavior?\] \[question 4\]: could multi-domain dietary education improve hba1c, and lipid profile? participants of experimental a group will receive a video about lifestyle education 5 minutes weekly for 3 weeks, a dietary board game 10 minutes weekly for 10 weeks, and a 24-hour dietary recall record 2 times weekly for 7 weeks. and participants of the experimental b group receive the usual clinical treatment. then experimental a and experimental b groups will cross over 12 weeks later. researchers will compare the effect of intervention between the experimental a group and the experimental b group.

cognitive function was measured by the saint louis university mental state (slums) score. and we exclude the dementia group according to the slums definition (\<21 if the participants graduated from senior high school or above, \<20 if the education level below senior high school). experimental group a received 10-week curriculum from 1st week to 10th week, and receive d usual clinical care from 13th week to 22th week. experimental b group received usual clinical care from 1st week to 10th week, and received 10-week curriculum from 13th week to 22th week.

Eligibility criteria:
inclusion criteria: * the onset age of diabetes mellitus is more than 20 years old * diagnosis of diabetes according to past history including type 2 diabetes mellitus or drug history including oral anti-diabetic drugs exclusion criteria: * slums meets the dementia definition. * hba1c ≥ 10.0% * rejected our study. * history of stroke. * history of depression. * history of psychiatric disease. * visual impairment. * hearing impairment. * can't understand the informed consent
ropivacaine and bupivacaine in sphenopalatine ganglion block in sinus surgery

Conditions: Functional Endoscopic Sinus Surgery (FESS)

Summary: postoperative analgesia after fess can be achieved through opioids, nsaids, topical or infiltration of local anaesthetic and regional techniques like sphenopalatine ganglion (spg) block, infraorbital nerve block and nasociliary block. as the current evidences regarding the benefit of spg block after fess is controversial, efficacy of sphenopalatine ganglion block will be evaluated using bupivacaine or ropivacaine as local anaesthetic in adult patients undergoing fess under general anaesthesia in this study.

functional endoscopic sinus surgery (fess) is a minimally invasive and safe technique for the treatment of sinonasal disease. although it is a minimally invasive and less traumatic procedure, it is usually associated with pain of mild to moderate intensity which reaches its maximum level in the first few postoperative hours. however, even low-level postoperative pain may be associated with delayed functional recovery and it frequently contributes to dissatisfaction with the procedure delay in return to work and readmission after surgery. postoperative analgesia after fess can be achieved through opioids, nsaids, topical or infiltration of local anaesthetic and regional techniques like sphenopalatine ganglion (spg) block, infraorbital nerve block and nasociliary block. as the sensory innervations of the spg supplies the nasal turbinates, nasopharynx and palate, spg block is expected to provide perioperative analgesia after fess. integration of regional anaesthesia with general anaesthesia technique can provide a better hemodynamic control, less perioperative opioid use, less bleeding and higher level of patients' satisfaction. reduction in surgical bleeding in fess can improve surgical field and also surgeons' satisfaction and a reduced opioid use may be translated into a less postoperative nausea \& vomiting, rapid recovery and early hospital discharge. but, the current evidences regarding the benefit of spg block after fess is controversial. in this randomized controlled trial, efficacy of sphenopalatine ganglion block will be evaluated using bupivacaine or ropivacaine as local anaesthetic in adult patients undergoing fess under general anaesthesia.

Eligibility criteria:
inclusion criteria: * 60 american society of anesthesiologists (asa) physical status i and ii patients * aged 18-60 years scheduled to undergo elective functional endoscopic sinus surgery for sinonasal disease such as rhinosinusitis, polyps and deviated nasal septum were enrolled exclusion criteria: * severe cardiovascular, pulmonary, hepatic, renal, neurologic or metabolic disease or coagulopathy * history of allergy to any of the medications being used in the study * previous surgery for sinonasal disease * pre-existing chronic pain not related to chronic rhinosinusitis * taking prescription pain medications or antidepressants * chronic alcohol or drug abuse * inability to comprehend the study protocol * pregnancy

Keywords: ropivacaine, bupivacaine
newborn screening for aromatic l-amino acid decarboxylase deficiency

Conditions: Aromatic L-amino Acid Decarboxylase Deficiency

Summary: parents of newborns will be invited to test if their newborns are affected with aromatic l-amino acid decarboxylase (aadc) deficiency.

parents of newborns will be invited to test if their newborns are affected with aromatic l-amino acid decarboxylase (aadc) deficiency. the routine newborn screening dried blood spots sample will be used to test if 3-o-methyldopa (3-omd) concentration elevates. if positive of screening test, further confirmation tests including physical examination and for mutation. genetic counseling and treatment option will be provided, too.

Eligibility criteria:
inclusion criteria: * babies born in taiwan receive regular new born screening suggested by ministry of heath and welfare. * parents or legal guardian sign in the informed consent form. exclusion criteria: * parents or legal guardian do not agree to sign in the informed consent form.

Keywords: aadc deficiency, newborn screening
use of lexiscan for myocardial stress perfusion computed tomography with a 3rd generation dual source ct system

Conditions: Cardiovascular Diseases; Coronary Artery Disease

Summary: the purpose of this study is to evaluate the feasibility, tolerability, safety, and image quality of low-radiation, dynamic perfusion ct of the heart in patients with suspected ischemic chest pain and a moderate or severe stenosis seen on coronary cta. secondary aims include the assessment of the diagnostic accuracy of ct perfusion imaging compared to either spect or invasive angiography.


Eligibility criteria:
inclusion criteria: 1. subject must present with symptoms (e.g. chest pain) suspicious for cardiac ischemia as determined by treating physician. 2. subject must have been referred for cardiac ct angiography or subject must have undergone clinically indicated spect with positive or equivocal findings or subject must have undergone clinically indicated spect with prior cardiac ct angiography that showed moderate or severe stenosis. 3. subject must be 18 - 85 years of age. 4. subject must provide written informed consent prior to any study-related procedures being performed. 5. subject must be willing to comply with all clinical study procedures. exclusion criteria: 1. subject is a pregnant or nursing female. exclude the possibility of pregnancy: * by testing (serum or urine beta hcg) within 24 hours before study agent administration, or * by surgical sterilization, or * post menopausal, with minimum one (1) year history without menses. 2. subject has severe asthma or copd requiring frequent inhaler use. 3. subject has prior diagnosis of obstructive cad that has not been revascularized. 4. subject with implanted rhythm devices (pacemaker, defibrillator). 5. subject has significant arrhythmia. 6. subject has high grade heart block. 7. subject has resting heart rate \< 45 bpm, systolic blood pressure \<90 mm hg, or has consumed caffeine within the last 12 hours. 8. subject has an acute psychiatric disorder. 9. subject is unwilling to comply with the requirements of the protocol. 10. subject has previously entered this study. 11. subject has an allergy against iodinated contrast agents or pharmaceutical stressors used in this study. 12. subject suffers from claustrophobia. 13. subject has impaired renal function (creatinine \> 1.5 mg/dl). 14. subject is in unstable condition. 15. st-elevations, new transient st changes greater than 0.05mv or t- wave inversions with symptoms 16. subject cannot safely be administered lexiscan™ per prescribing information as determined by investigator 17. subject has received interventional (pci, stenting) or surgical (cabg) treatment that may alter the cardiac condition regarding myocardial perfusion status and/or stenosis degree between cardiac cta, spect, and/or ct stress perfusion studies.

Keywords: computed tomography
monitoring and evaluation of micronutrients (sprinkles) project

Conditions: Anemia

Summary: the purpose of this study is 1) to evaluate the effectiveness in reducing anemia among children 6-24 months of age by providing daily micronutrient sprinkles through the government of pakistan's lady health worker program; 2) to assist in the monitoring the national sprinkles pilot project.

according to the recent national nutrition survey in pakistan (2001-2002), approximately 66.5% of children under five have anaemia. looking at the magnitude of the problem, national program for family planning (fp) and primary health care (phc) (also known as the lady health workers (lhw) program) has developed national sprinkles pilot project proposal with technical assistance of micronutrient initiative and aga khan university (aku). as the projects technical partner, aku is responsible to conduct the monitoring and evaluation of the project. the study will use a cluster randomized pre-post intervention design that compares before and after hemoglobin (hb) measurements, serum ferritin, serum retinol and urinary iodine among children who received sprinkles and age-appropriate feeding advice (sprinkles-advice group) and children who only receive age-appropriate feeding advice (advice-only group). age-appropriate feeding advice is part of the standard nutrition messages given by all lady health workers (lhws) during their community visits. however, intervention lhws, will give additional advice regarding the benefits of sprinkles and its appropriate use. the target population selected for the study consisted of children between the ages of six and eighteen months of age in the catchment area of the lady health workers.

Eligibility criteria:
inclusion criteria: * child's mother gives written consent after hearing an explanation of the study * random selection of child in household with more than one eligible child exclusion criteria: * any household in which consent is not given * children with any congenital or physical disability (such as cleft palate, down's syndrome, etc.) * child from a family which intends to migrate during the study period

Keywords: micronutrients