Kornimate/medical-research-clean huggingface dataset:
pilot study concerning an intelligent activity-based client-centred training system in neurorehabilitation

Conditions: Central Nervous System Diseases; Neurological Rehabilitation

Summary: the pilot study was performed to evaluate the usability, credibility and expectancy of an intelligent, activity-based client-centred training system (i-act), and the motivation towards its use in neurological rehabilitation over a short period of time.

a mixed-method study was performed in four rehabilitation centres in belgium. an homogenous convenience sample was recruited among persons with central nervous system disorders. participants received 3 x 45 minutes of training with the i-act system during six weeks, additional to conventional care. the canadian occupational performance measure (copm) was used to collect and evaluate patients' individual goals towards rehabilitation. these goals were discussed with the therapists before implementing movements and exercises for each patient in the i-act system. the following demographic data were obtained from the medical files: age, gender, and diagnosis. outcomes measures were collected at baseline (t0), after 2 (t1), 4 (t2) and 6 (t3) weeks of training and at 9 weeks follow-up (t4). the primary outcome measures were the intrinsic motivation inventory (imi), the system usability scale (sus), credibility/expectancy questionnaire (ceq), the canadian occupational performance measure (copm), and wolf motor function test (wmft). the secondary measures were the manual ability measure-36 (mam-36), modified fatigue impact scale (mfis), trunk impairment scale (tis), and active range of motion (arom). after final training with i-act, a semi-structured interview was performed to gather more information about the participants' perception towards i-act. for quantitative data, within-group differences of all the assessments were analysed using friedman's anova and wilcoxon signed-rank test. alpha was set at 0.05; no bonferroni correction was applied as it is not compulsory in an exploratory study and furthermore, results are regarded as hypothesis for further investigations. the qualitative data was collected and recorded with a voice recorder. no specific analysis was used as the interview collected data to support or oppose the findings of the quantitative data.

Eligibility criteria:
inclusion criteria: * age over 18 years old * a medical diagnosis of central nervous system disease * dysfunction in upper limb and/or core stability * persons with multiple sclerosis (ms) had to be free of treatment with corticosteroids for one month. * persons with stroke or spinal cord injury, had to be at least three months post injury. exclusion criteria: * severe spasticity (when spasticity impedes movement) * severe cognitive impairment (person is not able to understand and follow instructions) * severe communicative impairment (person is not able to answer questions) * severe visual impairment (person is not able to see the television screen) * persons who use an electric wheelchair
the usage of high-resolution magnetic resonance imaging in patients with disorders of consciousness for early diagnosis

Conditions: High-resolution Magnetic Resonance Imaging; Disorders of Consciousness

Summary: in this study, high-resolution brain functional magnetic resonance imaging (mri) was used to evaluate the differences in brain structure and brain function network between patients with different degrees of disturbance of cognition and healthy controls by means of cohort follow-up and control study. the changes of patients' the dynamic changes of learning, to explore its clinical value as an early diagnosis. combined with neurobehavioral scales and high-resolution brain structure, functional magnetic resonance imaging data to assess the brain structure, functional characteristics and consciousness of patients with impaired consciousness, and initially establish awareness of patients with recovery of consciousness predictable imaging signs. twenty eligible controls, 20 vs patients, and 20 mcs patients will be considered for inclusion in the inclusion / exclusion criteria. informed consent will be obtained as required before starting any registration process.


Eligibility criteria:
inclusion criteria: (1) no use of centrally acting drugs, (2) no use of neuromuscular function blockers and no sedation within the prior 24 h, (3) periods of eye opening indicating a preserved sleep-wake cycle, and (4) a diagnosis of vs or mcs established according to internationally established criteria exclusion criteria: magnetic resonance contraindications
effect of sodium thiosulfate on nephrotoxicity of cisplatin intraperitoneal heat-perfusion chemotherapy

Conditions: Epithelial Ovarian Cancer; Acute Kidney Injury Due to Circulatory Failure

Summary: ovarian cancer is the most lethal malignancy of the female genital tract. cytoreductive surgery combined with chemotherapy is the primary treatment for ovarian cancer, and radical tumor resection is an important means to improve the prognosis. however, even after complete tumor resection, 75% of patients with ovarian cancer still recur within 3 years after the initial treatment and eventually die from recurrence. in ovarian cancer, the lesions are located primarily in the peritoneal cavity. high-grade evidence demonstrates that the use of intraperitoneal hyperthermic chemotherapy (hipec) with cisplatin after cytoreductive surgery significantly improves the outcome in some patients with ovarian cancer. currently, this is the only non-pharmacologic treatment that reduces both the risk of recurrence and death from ovarian cancer with a multi treatment. however, hipec with cisplatin can lead to acute kidney injury, and a serious complication that can seriously affect the short and long-term prognosis of patients. sodium thiosulfate has previously been reported to reduce the incidence of acute kidney injury after hipec with cisplatin, but this finding has not been confirmed in a high-level study. therefore, we propose a multi-center, prospective, open-label, randomized, controlled trial including 110 patients with ovarian cancer who received hipec with cisplatin, to evaluate whether sodium thiosulfate combined with hydration (55 patients in the trial group) can reduce the incidence of acute kidney injury after hipec with cisplatin compared with hydration alone (55 patients in the control group), and to provide high-level evidence for the rationale of using sodium thiosulfate for nephrotoxicity relief in cisplatin hipec.


Eligibility criteria:
inclusion criteria:（the following conditions must be met at the same time） * patients treated with hipec with cisplatin. * estimated survival \> 12 weeks * age from 18 to 70 years * bone marrow reserve was well functioning. leukocytosis ≥ 3.0×10\^9/l, neutrophilic granulocyte ≥ 1.5 × 10\^9/l, platelet count ≥ 100 × 10\^9/l, and hemoglobin ≥ 80 g/l. * organs work well. ast ≤ 2.5 × uln, alt ≤ 2.5 × upper limit of normal(uln), total serum bilirubin ≤ 1.5 × uln, and creatinine ≤ 1.5 × uln * ecog score 0-1 * patients voluntarily sign an informed consent form exclusion criteria:（none of which was eligible）. * extensive abdominal adhesions * hipec with cisplatin for other medical conditions in the last 5 years. * receiving other drugs that cause kidney damage. * simultaneous use of amifotin for other diseases. * any situation of disease instability or potentially impact safety and adherence of patient. * chronic or acute nephropathy of any degree or other serious medical complications.

Keywords: epithelial ovarian cancer acute kidney injury hyperthermic intraperitoneal chemotherapy sodium thiosulfate
monitoring neural tissues properties by modulated imaging (mi)

Conditions: Brain Tumor

Summary: we have developed a safe, non-contact, intra-operative guidance system to optimize tumor resection in neurosurgery. the modulated imaging is non-contact optical imaging technology developed at the beckman laser institute, uci. compared to other imaging approaches, mi has the unique capability of performing both diffuse optical tomography and rapid, wide-field quantitative mapping of tissue optical properties within a single measurement platform. preliminary in vivo studies have shown that brain tumors, infiltrating tumor margins and normal brain may have intrinsically different optical properties.

while compatible with time-modulation methods, mi alternatively uses spatially-modulated illumination for imaging of tissue constituents. the modulated imaging system consists of 1. a light projection system that illuminates the tissue with spatial sinusoid patterns. 2. a ccd camera which collects the diffusely reflected light in a non-contact geometry. the wavelength of illumination can be selected by bandpass filtering of a broadband source,or by use of a monochromatic source. lastly, tissue fluorescence measurements can be performed by placing a combination of source-blocking and bandpass emission filters in front of the camera. the diffusely reflected amplitude of the modulated wave carries both optical property (absorption, fluorescence, scattering) and depth information. specifically, the sampling depth of the spatially-modulated wave is a function of the frequency of illumination and the tissue optical properties. during neurosurgery when nervous tissue is exposed by the attending neurosurgeon, intraoperative pictures will be taken using the modulated imager by the investigators. the imaging procedure may delay completion of the surgical case by an estimated 10 to 20 minutes. this is minimal prolongation considering most brain tumor resections take several hours. the images acquired will be processed after the surgical procedure and will not be available to the surgeon during the operative procedure.

Eligibility criteria:
inclusion criteria: * all nervous system tumor patients who undergo a preoperative mri,and undergoing central nervous system operative procedures for non tumor. exclusion criteria: * all emergency neurosurgical procedures.

Keywords: brain tumor
scaling community-clinical linkage models to address diabetes and hypertension disparities in the southeast united states

Conditions: Hypertension

Summary: the purpose of this study is to work with primary care physicians and their staff, and with community health workers (chws) to improve diabetes and hypertension management, health behaviors and improve blood pressure for south asian patients with uncontrolled diabetes and hypertension in primary care clinics in atlanta, georgia. the chws are community members who are trained to work with patients to address health needs holistically by providing information on wellness, nutrition, stress relief, and blood pressure management in a culturally-appropriate and language-appropriate manner.

the study will provide research training, technical assistance, and capacity-building to community and clinical sites in georgia for implementation of culturally tailored, evidenced-based chw programs to improve htn and diabetes management for south asians. in addition, the use a multi-theoretical framework to test the effectiveness of a chw-led intervention compared to usual care among south asian individuals with diabetes and uncontrolled htn in atlanta. the primary outcome is blood pressure control, defined as 130/80 mmhg. it is hypothesized that, compared to usual care, individuals receiving the chw intervention will be 20% more likely to achieve blood pressure control at 6 months. and to apply re-aim and cfir frameworks to delineate factors influencing appropriateness, fidelity, adoption, and maintenance of the intervention within clinical and community settings to optimize intervention replication. in addition, this study will serve as a national information and dissemination resource in the adaptation of evidence-based strategies to reduce geographic disparities in htn and diabetes across asian american groups.

Eligibility criteria:
chw intervention: inclusion criteria: * identified as of south asian ethnicity * are at least 21 years of age and younger than age 80 * had an appointment with a physician or mid-level clinician for routine non-emergent primary care in the last 12 months * a diagnosis of diabetes * a diagnosis of hypertension * an uncontrolled bp reading (\>130/80mmhg) in the last 6 months provider surveys inclusion criteria * clinicians employed by the clinic * have enrolled into the study. key informant interviews inclusion criteria * must be a provider, clinic manager, or community health worker. chw intervention exclusion criteria: * under the age of 21 and older than 80 * pregnant * type 1 diabetes or diabetes secondary to other conditions * malignancy or life threatening illness with life expectancy of \<5 years * inability to perform unsupervised physical activity * diagnosed cognitive deficits or limited decision-making capacity provider surveys inclusion criteria * clinicians who are unable to complete the survey in the english language. key informant interviews inclusion criteria * who are unable to participate in the interview conducted in the english language.
a study to evaluate ezetimibe in korean patients with primary hypercholesterolemia (0653-042)

Conditions: Hypercholerolemia

Summary: patients undergo 4-week placebo lead-in and diet period, and 12-week treatment period. clinical efficacy and safety is evaluated at weeks 4, 8 and 12. this study takes approximately 18 weeks for an individual patient to complete including post-visit at week 14.


Eligibility criteria:
inclusion criteria: * korean males or females at least 18 years of age with hypercholesterolemia
enhanced recovery after thoracic surgery

Conditions: Enhanced Recovery After Thoracic Surgery Protocol; C-reactive Protein; White Blood Cell Count; Neutrophil/Lymphocyte Ratio; Plathelet/ Lymphocyte Ratio; Lymphocyte/Monocytes Ratio; Thoracic Surgery

Summary: despite significant advances in perioperative care, major complications continue to be seen in patients undergoing major surgery. enhanced recovery after surgery (eras) protocols are perioperative care practices designed to reduce perioperative complications, maintain preoperative organ function, and provide early recovery by reducing the psychological and physiological response to major surgery and the intense stress response that develops following surgery. in this context, eras protocols have been established for many surgical procedures. one is the thoracic eras (erats) protocol applied to thoracic surgery, and the evidence for erats is increasing; literature data support the application of erats. however, there are limited studies on the application of eras protocols to thoracic surgery, and more studies are needed to develop erats protocols. postoperative complications may be reduced in patients who are treated with the eras protocol, their length of hospital stay (los) may be shortened, and patients may regain their initial functions faster. objectively, a marker indicating whether the eras protocol can be implemented effectively has not yet been demonstrated. reducing postoperative inflammation is thought to reduce los. based on this, the investigators think that the early recovery seen in patients who undergo eras is due to the effect of eras protocols on the inflammatory process. therefore, laboratory parameters such as c-reactive protein (crp), white blood cell count, neutrophil/lymphocyte ratio (nlr), platelet/lymphocyte ratio (plr), lymphocyte/monocytes ratio (lmr) may differ in patients who have undergone the eras protocol compared to patients who have not. these parameters have been evaluated comprehensively in studies as inflammatory parameters. in addition, clinical studies indicate that the c-reactive protein to albumin ratio (car) can be used as inflammatory and prognostic markers. also, the investigators hypothesized that inflammatory parameters used in routine clinical follow-up may be effective in evaluating the clinical consequences of erats protocols. in this study, the investigators aimed to evaluate the effects of the erats protocol on postoperative inflammatory parameters and investigate whether these parameters have a role in evaluating the effectiveness of the erats protocol.


Eligibility criteria:
inclusion criteria: * patients between 18-80 years of * patients underwent elective thoracic surgery, * american society of anesthesiologists (asa) i-ii-iii * body mass index (bmi) between 18.5-35 kg/m2 exclusion criteria: * patients with systemic inflammatory diseases * patients with a history of anti-inflammatory and anti-allergic drugs, * patients with a history of corticosteroid usage, * patients who had received intraoperative blood product transfusions, * patients who had previously undergone thoracic surgery, * patients with missing data
pilot rct of self-stigma treatment for first episode psychosis

Conditions: First Episode Psychosis; Youth

Summary: the overall purpose of the proposed exploratory intervention development application, is to conduct research that will inform the adaptation and preliminary testing of nect modified for youth (aged 15-24) with first episode psychosis (fep), targeting self-concept and illness conceptions to increase treatment engagement. the specific aims of the project are to: 1) adapt nect to be responsive to the needs and preferences of youth with fep, and 2) assess the feasibility, acceptability and preliminary effectiveness of the modified intervention (nect-ya) combined with coordinated specialty care (csc) services, compared to csc services alone, in a small (n = 40) rct.

the investigators will conduct a small rct of the modified intervention (nect-ya), combined with csc, in comparison with csc alone, with 40 persons recruited from three fep programs, assessing acceptability and feasibility, and collecting data on primary outcome (service engagement and therapeutic alliance), related outcomes (self-esteem, hopelessness, and social functioning) and mechanisms of action (self-stigma, illness conceptions and coping). the investigators will also collect qualitative data on participants' impressions of nect-ya, which will inform additional revisions of the manual.

Eligibility criteria:
inclusion criteria: 1. meets criteria for fep youth based on the following definition: age 15-24, onset of psychotic symptoms within the last 5 years, and an absence of a primary substance use or mood disorder that could be causing the psychotic symptoms (confirmed by program eligibility); 2. meets criteria for moderate (defined as a mean score of 1-1.5 on the 0-3 scale of the internalized stigma of mental lllness scale \[ismi\]) or elevated (defined as a mean score of 1.5-3 on the 0-3 scale of the ismi) self-stigma; 3. speaks english well enough to complete assessments and participate in groups; 4. is able to provide informed consent to participate. exclusion criteria: does not meet any of the above inclusion criteria.
battlefield acupuncture with sodium hyaluronate injections

Conditions: Knee Osteoarthritis

Summary: the study evaluates pain relief and subsequent range of motion changes combining battlefield acupuncture with sodium hyaluronate vs local anesthetic and sodium hyaluronate

sodium hyaluronate is fda approved for knee osteoarthritis. it is a widely used treatment for this condition. this does provide immediate pain relief and is often used in conjunction with lidocaine and ropivacaine to both improve pain relief and treatment tolerance. battlefield acupuncture has been showing promise as an adjunct pain relief treatment option. if used during intra articular visco supplementation knee injections, this may provide pain relief and positive changes in range of motion without the need of local anesthetic being injected into the joint space.

Eligibility criteria:
inclusion criteria: * patients of the bamc orthopaedic clinic * active duty, dependent and civilians * ages 18-65 * diagnosed with knee osteoarthritis by their orthopaedic provider * determined to be eligible for sodium hyaluronate injections by their orthopaedic provider exclusion criteria: * patient without knee osteoarthritis diagnosis * patient requiring immediate surgery for their knee complaints * patients younger than 18 or older than 65 * pregnant patients * patients without active pain * patients with history of knee arthroplasty * patients with auricular deformity which would affect bfa * patient with history of vasovagal secondary to needles or injections * patients with active infection at bfa treatment sites
a study of cabergoline for the treatment of cocaine dependence - 1

Conditions: Cocaine-Related Disorders; Substance-Related Disorders

Summary: the purpose of this study is to assess cabergoline for the treatment of cocaine dependence

to assess the efficacy and safety of cabergoline in reducing cocaine use in subjects with cocaine dependence. this is a db, placebo-controlled, parallel group design study where subjects will receive either .5mg cabergoline or placebo for 12 weeks with a 4 week follow-up.

Eligibility criteria:
inclusion criteria: must have a dsm-4 criteria for cocaine dependence; be seeking treatment for cocaine dependence; have the ability to understand and provide written informed consent; females of child-bearing potential using proper method of birth control. exclusion criteria: additional criteria available during screening at the site.
efficacy and safety of biphasic insulin aspart 30 in subjects with type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in asia. the aim of this trial is to investigate the efficacy and safety of biphasic insulin aspart 30 as start insulin in subjects with type 2 diabetes failing oad therapy.


Eligibility criteria:
inclusion criteria: * type 2 diabetes for at least 24 months * bmi between 18 and 30 kg/m2 * insulin naive subjects * oad treatment with max two oads alone or combined with other therapy * hba1c between 7-12% exclusion criteria: * type 1 diabetes * receipt of any investigational drug within the last three months prior to this trial * current or previous treatment with thiazolidiones within the last 6 months * oad treatment with three or more oads within the last 4 months
deuterated phenanthrene tetraol in smokers who are at high risk for lung cancer

Conditions: Lung Cancer; Squamous Lung Dysplasia; Tobacco Use Disorder

Summary: this clinical trial studies deuterated phenanthrene tetraol in smokers who are at high risk for lung cancer. studying samples of urine in the laboratory from smokers who are at high risk for lung cancer may help doctors learn more about biomarkers related to cancer.

primary objectives: i. to determine the relationship between urinary deuterated (\[d10\]) phenanthrene tetraol (phet) level, phet:phenanthrols (hophe) ratio, and the presence of bronchoepithelial metaplasia and/or dysplasia in smokers who have undergone screening bronchoscopy at roswell park cancer institute (rpci). outline: patients receive deuterated phenanthrene tetraol orally (po). urine samples are collected for laboratory studies for 6 hours after dosing.

Eligibility criteria:
* current or former smoker * 18 years of age or older * documentation of a diagnosis of no dysplasia, dysplasia, or metaplasia on bronchoscopy (white light and/or autofluorescence) conducted less than or equal to 10 years prior to registration * not pregnant or breastfeeding * able to provide written informed consent indicating an understanding of the nature of the study * willing to comply with study requirements, including taking \[d10\]phenanthrene in water with 20% ethanol * no previous history of aerodigestive cancer * not currently undergoing treatment for any cancers. exception: basal cell or squamous cell skin cancer * not currently taking any other investigational agents * no history of allergic reaction to \[d10\]phenanthrene or similar compounds * no major medical comorbidities, for example, renal dysfunction, heart function, and diabetes, to be adjudicated by study physicians * not a former or recovering alcoholic * no use of metronidazole or antabuse less than or equal to 7 days prior to \[d10\]phenanthrene dosing, as they could potentially interact with ethanol