Kornimate/medical-research-clean huggingface dataset:
incidence and predictors of delirium in the trauma intensive care unit：prospective study

Conditions: Delirium, Risk Factor

Summary: background delirium is an acute neuropsychiatric syndrome, and its causes remain complex and not fully comprehended. patients in trauma intensive care units are at high risk for delirium and are greatly affected by its adverse outcomes. as there are currently no effective pharmacological treatments or approaches for delirium, it is crucial to focus on identifying the risk factors for delirium and implementing early prevention strategies. objective analyzing the incidence and risk factors of delirium in trauma intensive care unit patients. method this study is a prospective research that focuses on all patients in the trauma intensive care unit of a medical center. data collection will be conducted through questionnaires and electronic medical records. a total of 200 participants will be conveniently selected for the study. upon admission to the intensive care unit, each patient will complete a basic information questionnaire, and their medical records will be collected daily until they are discharged from the intensive care unit. the study incorporates various assessment scales including intensive care delirium screening checklist (icdsc), confusion assessment method for the intensive care unit (cam-icu), acute physiology and chronic health evaluation ii (apache-ii), injury severity score (iss), and malnutrition universal screening tool (must). statistical analysis will be done by using ibm spss 24.0 for windows. descriptive statistics including mean, standard deviation, and percentages will be used to present demographic information. logistic regression analysis will be applied to identify the key predictive factors for delirium risk. expected outcome and clinical application this study anticipates that the non-modifiable risk factors for trauma intensive care unit patients include age, substance use, chronic diseases, traumatic brain injury, prior surgery, frailty, apache ii score, iss, and asa anesthesia classification. the modifiable risk factors include malnutrition, polypharmacy, electrolyte deficiency, metabolic acidosis, pain, mechanical ventilation, physical restraints, total surgical duration, intraoperative blood loss, and low hemoglobin. by understanding these risk factors, high-risk patients can be identified and preventive measures can be implemented to reduce the occurrence of delirium. furthermore, addressing modifiable risk factors can help in reducing the risk or severity of delirium.


Eligibility criteria:
inclusion criteria: * patients who admitted to trauma intensive care unit. * age ≥18. * patients who belongs to surgical or trauma subject. exclusion criteria: * patients who stay in trauma icu less than 24hrs. * patients who can not communicate with chinese or taiwanese. * patients who was diagnosed dementia. * patients who was evaluated -4 or -5 on richmond agitation-sedation scale.
safety and efficacy of falatescan (technetium tc 99m ec20) in patients with known suspected recurrent or metastatic cancer from a solid tumor

Conditions: Recurrent or Metastatic Cancer; Head and Neck Cancer; Pancreas Cancer; Bladder Cancer; Testicular Cancer

Summary: the folate receptor is over-expressed on many types of cancer cells and new folate receptor targeted therapies are being developed to target cancer cells that over-express the folate receptor. as with other targeted therapies, it is important to develop diagnostic tests that will provide accurate information on folate receptor status and aid in selecting patients that may benefit from folate-targeted therapy.

this phase ii, limited institution, open-label, single-arm, baseline-controlled study is designed to obtain data on the percentage of patients with recurrent or metastatic cancer from a solid tumor (including, but not limited to, breast, lung, mesothelioma, liver, colorectal, prostate, head and neck, pancreas, bladder and testicular cancer) with increased uptake of falatescan in tumors, correlate the immunohistochemical staining findings with the folatescan images, and verify product safety in patients with suspected recurrent or metastatic disease from any solid tumor.

Eligibility criteria:
inclusion criteria: * patients must meet the following eligibility requirements to be enrolled in the study: 1. patient must be 18 years of age or older. 2. patient must have known or strongly suspected recurrent or metastatic cancer from a solid tumor with at least one identifiable lesion \> 1.5 cm as diagnosed by conventional imaging. 3. patient must have adequate kidney function defined as serum creatinine of \< 1.5 x uln. 4. patient must have adequate liver function defined as transaminases (sgot and/or sgpt) may be up to 2.5 x uln if alkaline phosphatase is \<uln or alkaline phosphatase may be up to 2.5 x uln if transaminases are \< uln. if alkaline phosphatase is outside of these parameters and is due to bone metastases verified by assessment of isoenzymes, then the subject is eligible. 5. patient must provide written informed consent prior to enrollment. exclusion criteria: * patients must be excluded in any of the following conditions are present: 1. patient is pregnant or breastfeeding. 2. patient is simultaneously participating in another investigational drug study, excluding the follow-up phase. 3. patient has received an investigational agent within 7 days prior to enrollment. 4. patient is unable to tolerate conditions for radionuclide imaging. 5. patient has been administered another radiopharmaceutical that would interfere with the assessment of technetium tc 99m ec20.

Keywords: recurrent or metastatic cancer head and neck cancer pancreas cancer bladder cancer testicular cancer
evaluation of the effect of self-assembling peptide p11-4

Conditions: Dental Caries

Summary: dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that results in the phasic demineralization and remineralization of dental hard tissues. these tissues have poor regeneration capability because of the lack of both regenerative cells and vascularization. in the complex caries progression process involving dietary sugars, bacterial metabolism and demineralization, the collagenous organic matrix becomes exposed and destroyed by resident and bacterial proteases, allowing the lesion to expand

it is possible to find numerous noninvasive or minimally invasive therapies for caries such as hygiene education, fluorides, phosphopeptide compounds, xylitol and infiltrative resins. however, when caries progresses to the point of breaking down the dental tissues, composite restorations are imperative to preserve the tooth functionality. during the execution of routine dental restorations, the hybrid structure formed by the dental bonding procedure occurs through the interaction and subsequent polymerization of monomers around the demineralized collagen matrix. the oral cavity is a severe environment for the resin-dental bond to survive for a reasonable length of time, with thermomechanical changes, chemical attacks by acids and enzymes and other factors posing routine daily challenges. therefore to achieve effective and stable bonding, the preservation of dentin collagen is critical, since collagen represents the major organic component of the dentin matrix. based on today's understanding of the dental biomineralization process, new efforts have been made to develop synthetic analogues of non-collagenous proteins (ncps), which are involved in the events of nucleation and growth of hydroxyapatite crystals in hard tissues such analogues have been designed mirroring the amphiphilic characteristics of ncps, with polar groups complexing inorganic ions and non-polar side chains governing the matrix-matrix interactions.

Eligibility criteria:
inclusion criteria: * patients included in the study will be required to present at least one permanent molar with an active deep carious lesion without pulpal involvement. * age of patient: 18 -30 years * carious lesions will be standardized by means of clinical and radiographic examinations performed before the procedures exclusion criteria: * teeth with deep dentinal lesions with pulpal involvement, abscess, pain or swelling * developmental disorders and adjacent soft tissue lesions * patients with systemic illness will be excluded
effect of tens on patients with palmar hyperhidrosis

Conditions: Hyperhidrosis Primary Focal Palms

Summary: to investigate the effectiveness of transcutaneous electrical nerve stimulation on hyperhidrosis severity on patients with primary palmar hyperhidrosis.

hyperhidrosis might be a primary condition or secondary condition due to medications or systemic disorders. primary hyperhidrosis is usually focal,bilateral, and symmetric. it mainly affects the axillae, palms, soles, face, and scalp. the incidence of primary hyperhidrosis has been reported to be between 0.6%\~2.8% in both genders. symptoms usually begin in childhood or around puberty. it interferes with daily social and occupational activities of patients and significantly impacts their quality of life. various treatments have been proposed to control primary hyperhidrosis. the treatment options for hyperhidrosis include topical therapy, anticholinergic, iontophoresis, botulinum toxin and surgery. in addition to these treatment options for hyperhidrosis, several medical devices delivering energy to destroy sweat glands are undergoing promising clinical investigation. microwave technology, several lasers (such as 1,064-nm, 1,320-nm, and 1,440-nm neodymium: yttrium- aluminum-garnet laser, 924-nm and 975-nm diode laser, long-pulsed 800- nm diode laser), micro needle radio frequency, and ultrasound technology could be included as example of the device. in spite of these treatment options, the best therapeutic choice is still undefined. this concept encourages us to investigate the effectiveness of recent technique in the current research. up till now, the available literatures show a gap in knowledge and lack of well-designed studies. we will concern on the effect of transcutaneous electrical nerve stimulation on hyperhidrosis severity on patients with primary palmar hyperhidrosis.

Eligibility criteria:
inclusion criteria: * • age range from 18 to 30 years old. * patients will be from both sexes. * body mass index from 18.5 to 24.9 * subject suffer from primary palmar hyperhidrosis. * no clinical treatment for palmar hyperhidrosis within the past month. exclusion criteria: * • patients outside the target range. * patients who were pregnant or lactating. * patients who had metal implants such as a pacemaker. * patients who had history of ischemic heart disease or arrhythmias. * patients who had any other diseases that could be the cause ofsecondary hyperhidrosis.
feasibility of the infra-red illumination for facilitation of video scope-tracheal intubation

Conditions: Airway Morbidity; Covid19; Trachea

Summary: airway securing through the placement of an endotracheal tube continues to be the definitive and the global standard management. the successful first attempt is aimed to avoid the consequences of multiple intubation trials as bleeding, tissue swelling, and airway contamination from gastric content that led to considerable morbidity and mortality. visualization of the larynx and the glottic opening is the key to first-pass success requiring long-term training and availability of specific equipment concerned to that. for confirmation of the position endotracheal tube or its displacement, various clinical and equipment aids to that which are not valid or limited in different scenarios. video laryngoscopes (vl) have been proposed to improve laryngeal visualization, hence a higher first-pass success rate accomplished. despite that, there are limitations of video laryngoscope use in different circumstances that requiring adding of other aids to facilitate endotracheal intubation. x

airway securing through the placement of an endotracheal tube continues to be the definitive and the global standard management. the successful first attempt is aimed to avoid the consequences of multiple intubation trials as bleeding, tissue swelling, and airway contamination from gastric content that led to considerable morbidity and mortality. visualization of the larynx and the glottic opening is the key to first-pass success requiring long-term training and availability of specific equipment concerned to that. for confirmation of the position endotracheal tube or its displacement, various clinical and equipment aids to that which are not valid or limited in different scenarios. video laryngoscopes (vl) have been proposed to improve laryngeal visualization, hence a higher first-pass success rate accomplished. despite that, there are limitations of video laryngoscope use in different circumstances that requiring adding of other aids to facilitate endotracheal intubation. the proposal of this study is to assess the feasibility and the impact of infrared/near-infrared (ird) light on the performance of video-laryngoscopy and reduction of the time needed for endotracheal intubation and increase the credibility of the device. data-collection will be started after induction of the anesthesia and ended at the confirmation of endotracheal tube position

Eligibility criteria:
inclusion criteria: * age above 18 years * general anesthesia that needs endotracheal intubation * all mallampati score 1-3 * asa physical status 1-3 exclusion criteria: * refuse or unable to sign the consent. * pregnancy * emergency cases * history of or expected difficult intubation * maxillofacial abnormality or trauma * age below 18 years * rapid sequence induction * skin disorders and skin light sensitivity (sle, lupus ....) * impaired head and neck mobility * scars or skin injuries at the neck

Keywords: infra-red illumination retrograde transcutaneous videoscope-tracheal intubation
preeclampsia and contact activation

Conditions: Preeclampsia; CAS; Misfolding Disease, Protein

Summary: preeclampsia (pe) affects approximately 5% of all pregnancies with 2,500 cases registered annually in denmark. pe is characterized by incomplete modelling of the spiral arteries of the uterus, hypertension, inflammation, hypercoagulability and proteinuria. neonatal complications and increased cardiovascular risk are common features of the syndrome. pe shares pathophysiologic features with recognized protein misfolding disorders and misfolded proteins are present in urine from women with pe. misfolded proteins are potent activators of the contact system (cas) which is involved in inflammation, coagulation and fibrinolysis. plasminogen activator inhibitor 2 (pai-2) regulates important fibrinolytic processes in the placenta. the oxidative milieu characterizing pe may trigger misfolding of pai-2 which then loose inhibitory capacity, but gain cas-activating capacity. thus, misfolding of pai-2 may affect the fibrinolytic system in the placenta and compromise the modelling of the spiral arteries. moreover, misfolded pai-2 may contribute to the hypercoagulability and the inflammatory conditions characterizing women with pe. the aim of the present study is i) to characterize cas in women with pe, ii) to study the cas-activating capacity of misfolded pai-2 and iii) to develop and apply immunochemical methods for determination of native and misfolded pai-2 in plasma.


Eligibility criteria:
inclusion criteria: * pregnant women developing preeclampsia exclusion criteria: * healthy pregnant women

Keywords: contact activation system, pai-2
circulating tumors cells and circulating endothelial cells in renal cell carcinoma

Conditions: Renal Cell Carcinoma

Summary: the purpose of this study is to see if researchers can detect circulating tumor cells (ctc) and circulating endothelial cells (cec) in the blood.

circulating tumors cells (ctcs) and circulating endothelial cells (cecs) are found in the peripheral blood of most common malignancies and are promising surrogate biomarkers. the cellsearchtm ctc assay is currently approved by the food and drug administration as an adjunct for monitoring disease status in breast, prostate and colon carcinomas; and evidence in breast cancer suggests that ctcs are an independent predictor of overall survival and progression-free survival. evolving data demonstrates a potential role of ctcs as a surrogate assessment for treatment response. the benefit of this approach in renal cell cancer(rcc) is unknown and further investigation is needed to determine the feasibility of using the cellsearchtm ctc assay in this malignancy. circulating endothelial cells (cecs) are increased in the peripheral blood of cancer patients and appear to be a marker of tumor related angiogenesis. studies suggest that cecs increase in the setting of progressive disease and decrease in response to treatment with an antiangiogenic agent. although current data evaluating cecs in rcc is limited, there is significant interest in cec evaluation as a marker of treatment response given the majority of current fda approved rcc therapies target tumor angiogenesis. the overall objective of this protocol is to obtain preliminary data and experience using our cell search assay system which can be used for future grant applications. our hypothesis is that ctcs and/or cecs will be valuable and versatile biomarkers for therapeutic response, determination of relapse and survival in patients with renal cell cancer.

Eligibility criteria:
inclusion criteria: * any patient with radiographic or histologic evidence of renal cell carcinoma who is scheduled to begin treatment with one of the following antiangiogenic agents: sunitinib, sorafenib, temsirolimus or bevacizumab. * patients must be candidates to be treated with one of the above agents but there is no limit on the number of prior therapies (i.e. first line or subsequent treatment setting). * patients scheduled to undergo debulking nephrectomy prior to beginning systemic therapy do not require histologic diagnosis prior to baseline testing. * must be able and willing to sign informed consent. * patients must be 18 years or older.

Keywords: cancer kidney renal cell tumor cells circulating tumor cells circulating endothelial cells
incidence of deep vein thrombosis on central venous catheters in the post operative period of carcinologic surgery

Conditions: Critically Ill; Central Venous Catheter Thrombosis; PARENTERAL NUTRITION; POST OPERATIVE

Summary: the objective is to determine the incidence of thrombosis on central venous catheters in patients hospitalized in a surgical critical care unit, in the immediate postoperative period of urological or digestive carcinological surgery, and receiving parenteral nutrition.

the post operative period, wich is a critically ill condition, and history of cancer are related to a high risk of venous thrombosis. catheter is one of the most common complication of parenteral nutrition and is also related to thrombosis. the combination of theses conditions increases the risk of venous catheter thrombosis. , since, there is no data evaluating this risk nowadays, the objective of this study is to determine the incidence of thrombosis on central venous catheters in patients hospitalized in a surgical critical care unit, in the immediate postoperative period of urological or digestive carcinological surgery, and receiving parenteral nutrition.

Eligibility criteria:
inclusion criteria: * hospitalization in surgical intensive care in the immediate post-operative period * surgery for cancer * central venous catheter placement for parenteral nutrition * written consent dated and signed before doppler examination exclusion criteria: * patient \< 18 years old * pregnancy * surgery with no indication for parenteral nutrition on central venous access
preterm infant growth

Conditions: Growth; Development; Infant

Summary: the purpose of this study is to assess growth of preterm infants fed a test formula compared to a standard formula up to the first 4 months of corrected gestational age.


Eligibility criteria:
inclusion criteria: * born aga * exclusively formula-fed * 28-34 weeks ga at birth * intact gi tract, tolerating full oral feeds * expected to be discharged from the hospital within a minimum of 24 hours, maximum of 5 days exclusion criteria: * severe respiratory disease defined as needing mechanical ventilation at discharge * any significant systemic diseases that could affect growth. this includes cardiac, neurologic, or gi conditions. * major congenital malformation, history of gi surgery, severe postnatal complications * daily or routine diuretic use at time of discharge * receiving more than 10% of daily kcals from food additives such as thickeners * currently participating or having participated in another conflicting clinical trial.

Keywords: infant formula premature infants growth and development
can kangarooing small babies on the back of a mother keep them warm and stable

Conditions: Body Temperature; Oxygen Saturation; Heart Rate; Respiratory Rate; Sleep Pattern

Summary: the purpose of this study was to assess the effectiveness of kangarooing small babies on the back of a mother

after the study was explained (risks and benefits) and written informed consent was received from participants, an individually controlled randomized crossover clinical trial was conducted to examine the effectiveness of chest-to-back (cb) skin-to-skin contact (ssc) compared with the standard. the trial was done in accordance with the protocol, good clinical practice, and the national regulatory and ethics guideline of ethiopia (which is in line with the helsinki declaration).

Eligibility criteria:
inclusion criteria: * neonates with lbw (\<2500 grams) * born prematurely (\< 37 complete weeks of gestation) exclusion criteria: * less than 35 weeks of gestation on the day of enrollment to trial * malformations or birth disabilities * dependent on oxygen or iv fluid * any disorder that was deemed necessary for exclusion by the investigator.