Kornimate/medical-research-clean huggingface dataset:
breakfast size and weight loss in overweight/obese adults

Conditions: Obesity

Summary: effect of high carbohydrate and high protein breakfast on weight loss, ghrelin, hunger and craving scores in obese men and women. d jakubowicz, m boaz, j wainstein, o froy background: obesity underlying endocrine, metabolic and eating behaviour features promotes weight gain, increase of hunger, and carbohydrate (carb) craving. restrictive diets either in calories or carb produce withdrawal effect, that further exacerbate carb craving resulting in rapid return of obesity. meal timing and composition has shown to play a pivotal role in appetite regulation through several hormonal systems such as ghrelin. the investigators hypothesized that to be successful; a weight loss strategy must change the hormonal environment to increase satiety while reducing hunger and craving. objectives: to assess weight loss, satiety, hunger, cravings and ghrelin response to two isocaloric diets. additionally, these outcomes were measured in response to meal challenge. methods: in this randomized, treatment controlled clinical trial, 146 obese, sedentary adults with impaired glucose tolerance will be assigned to low carb diet (lchbd) or an isocaloric diet with a high carb, high protein breakfast (hcpbd),1400 kcal for women and 1600 kcal for men. lchbd breakfast will provide 300 kcal with carb: protein: fat of 13:40:48. hcpbd breakfast will provide 600 kcal with 50:20:30. from baseline until week 16 participants will take part in a supervised weight loss diet, followed until week 32 by a maintenance period. anthropometric measures, ogtt for glucose and insulin, vas-measured hunger and satiety and food craving inventory analysis will be performed at baseline, week 16 and week 32.


Eligibility criteria:
inclusion criteria: * adult * male and female * obese * sedentary * glucose intolerant/insulin resistant exclusion criteria: * pregnant/lactating * malignancy * taking weight loss medications * know eating disorder

Keywords: obesity weight loss ghrelin satiety hunger
rubidium-82 pet and tc-99m-mibi spet: a head to head comparison

Conditions: Coronary Artery Disease

Summary: the main purpose of this study is to compare myocardial perfusion imaging using rubidium-82 pet with tc-99m-mibi spet, in the evaluation of significant coronary artery disease (cad).


Eligibility criteria:
inclusion criteria: * referred for scintigraphy to assess myocardial ischaemia * ability to give informed written consent. exclusion criteria: * impaired capacity to consent * pregnancy, or breastfeeding * allergy to iv contrast * renal failure * severe uncontrolled asthma * claustrophobia

Keywords: coronary artery disease myocardial perfusion imaging rubidium technetium
echo-cardiographic assessment of cardiovascular characteristics during pregnancy and postpartum periods

Conditions: Pregnancy

Summary: the purpose of this echocardiographic study is to restudy the longitudinal changes in cardiac size and function during and after pregnancy in healthy women using relatively new parameters of systolic and diastolic function as well as classical measures of left ventricle (lv) function using contemporary echocardiographic machines. we, the researchers at hillel yaffe medical center, will assess diastolic function and its possible relation to shortness of breath.

a comprehensive echocardiographic study of the heart will be conducted in the first, second and third trimesters of pregnancy and 3 months postpartum. determination of left ventricular dimensions, transvalvular doppler flow, ejection fraction, stroke volume, cardiac output, pulmonary vein flow, tissue doppler, flow propagation, global and segmental strain parameters, timing of peak strain and various parameters of diastolic function will be obtained. from these data normal values for various stages of pregnancy will be determined as well as range for changes expected during longitudinal follow-up will be determined.

Eligibility criteria:
inclusion criteria: * healthy women * first trimester of a normal pregnancy * normal baseline echocardiogram exclusion criteria: * pregnancy with more than one fetus. * any hemodynamically significant cardiac condition * any known systemic disease * poor quality echocardiogram

Keywords: myocardial strain myocardial function pregnancy postpartum echocardiography myocardial adaptation to pregnancy systolic function diastolic function
the effect of tdcs combined with functional task training on motor recovery in stroke patients

Conditions: Stroke; Stroke, Acute; Motor Function

Summary: we propose to enhance the effects of brain plasticity using a powerful noninvasive technique for brain modulation consisting of navigated transcranial magnetic stimulation (tms) priming with transcranial direct current stimulation (tdcs) in combination with motor-training-like constraint-induced movement therapy (cimt).


Eligibility criteria:
inclusion criteria: 1. age 18-90 2. first-time clinical ischemic or hemorrhagic cerebrovascular accident as noted in the radiological (or physician's) report; 3. the ability to extend =20° at the wrist and 10° at the metacarpophalangeal and interphalangeal joints of all digits; 4. participants must demonstrate adequate balance while wearing the restraint; 5. the ability to stand from a sitting position and the ability to stand for at least 2 minutes with or without upper extremity support; 6. weakness, defined as score of 15-55 (out of 66) on arm motor fugl-meyer (fm) scale; and 7. stroke onset more then 6 months prior to study enrollment. exclusion criteria: 1. significant pre-stroke disability; 2. where applicable (a history of depression before the stroke); 3. any substantial decrease in alertness, language reception, or attention that might interfere with understanding the instructions for the motor testing; 4. excessive pain in any joint of the paretic extremity; 5. contraindications to single-pulse tms (tms will be used to measure cortical excitability) such as metal head implants; 6. advanced liver, kidney, cardiac, or pulmonary disease; 7. a terminal medical diagnosis consistent with survival 1 year; 8. coexistent major neurological or psychiatric disease (to decrease the number of confounders); 9. a history of significant drug abuse in the prior 6 months; 10. the use of certain neuropsychotropic drugs such as tricyclics, antidepressants, or 51 of 66 carbamazepine; 11. active enrollment in a separate intervention study targeting stroke recovery; ( 12. previously applied constraint-induced motor therapy and/or tdcs treatment for stroke; and 13. a history of epilepsy before stroke (or episodes of seizures within the last six months).
effect of mobilization on acute postoperative pain and nociceptive function

Conditions: Pain, Postoperative; Pain Sensitivity, Postoperative

Summary: aim of the present study is twofold. * first we want to evaluate the effect of mobilization on acute postoperative pain * second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty

little is known about the effect of mobilization on acute postoperative pain and mobilization induced pain, and if altered pain sensitivity occur under these circumstances. * first we want to evaluate the effect of mobilization on acute postoperative pain using the visual analog scale (vas) * second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty, using two simple tools, the pain matcher and a pressure algometer.

Eligibility criteria:
inclusion criteria: * patients scheduled for total unilateral knee arthroplasty exclusion criteria: * cognitive dysfunction or peripheral / central neurological dysfunction inconsistent with protocol completing * alcohol and medical abuse (as defined by the national health service of denmark * daily use of opioids or glucocorticoids
treatment of chronic insomnia according to yin yang theory and its correlation with circadian rhythm

Conditions: Chronic Insomnia; Circadian Rhythm; Traditional Chinese Medicine

Summary: the purpose of this study is to assess the safety and efficacy of traditional chinese medicine (tcm) according to yin yang theory for treatment of chronic insomnia .

all subjects giving written informed consent. in this multicenter, controlled, prospective cohort study, the outpatient and inpatient chronic insomnia patients' baseline demographic data were collected, including age, gender, education background, and medication history. venous blood samples were collected and sent to laboratory test for blood routine, and blood biochemistry at baseline and week 4. the pittsburgh sleep quality index (psqi) was used to assess the patients' sleep quality at baseline and week 4. objective sleep quality data is assessed by wearing a sleep wearable devices. the classic morningness-eveningness questionnaire and wearable devices was used to assess the patients' chronotype at baseline and week 4.subjects who visit the tcm clinic of this project received suanzaoren decoction and huanglian wendan decoction orally twice daily for 4 weeks. add or subtract chinese herbal medicine according to the different clinical manifestations of each patient. subjects from tcm clinic who had previously taken western medicine hypnotics continued taking them, and for those who had not taken before, western medicine hypnotics shall not be given/prescribed. subjects who visit the western medicine clinic of this project received estazolam 1mg tablet orally once daily for 4 weeks. the participants will have a follow-up visit every two weeks, and the prescription would be adjusted according to the condition of illness.cessation rate of western medicine hypnotics was assessed at month 6.

Eligibility criteria:
inclusion criteria: * outpatients or inpatients. * it conforms to the chronic insomnia diagnosis standard of chinese adult insomnia diagnosis and treatment guide (2017 edition). * chronic insomnia patients with yin yang imbalance and ying wei disharmony syndrome. * informed consent, voluntary participation in the study. exclusion criteria: * sleep apnea syndrome leads to insomnia. * severe depression, suicidal tendency or having committed suicide. * pregnant and lactating women. * it has serious primary heart, liver, lung, kidney, blood or serious diseases affecting its survival, such as: tumor or aids, scr \> 1.5n (n is the upper limit of normal value), alt \> 2n (n is the upper limit of normal value), wbc \< 3.0 × 109 / l; * those who cannot give full informed consent due to mental disorders. * according to the researcher's judgment, other situations that are not suitable for the group, such as the change of working environment. * subjects who are participating in other clinical studies.
the effects of anaesthetic agents on postoperative delirium

Conditions: Delirium

Summary: the purpose of this study is to prove the correlation between the post-operative delirium (pod) and anesthetic agents. the investigators hypothesized that intravenous anaesthetics would show the lower incidence of pod, compared with inhalation anaesthetics in off-pump cabg.

the medical records of the patients undergoing off-pump coronary artery bypass grafting (cabg) in konkuk university medical centre from jan 2010 to aug 2014 were retrospectively reviewed.

Eligibility criteria:
inclusion criteria: * patients undergoing off-pump coronary artery bypass grafting exclusion criteria: * other concurrent surgery * conversion from off-pump coronary artery bypass grafting to on-pump coronary artery bypass grafting
ketamine analgesia in third molar surgery

Conditions: Pain; Postoperative

Summary: background and purpose outpatient surgery (day case surgery) is increasing. when the patients go home on the same day, this demands safe pain relief. a reduction of morphine (opioid) use is sought because of side effects and the dependency risk. an effective alternative to opioids is ketamine, which lacks the side effects of opioids but provides powerful analgesic effects. method at the start of surgery, ketamine or placebo will be given in a vein to evaluate if the acute pain decreases significantly. inflammation is known to cause pain. by measuring different proteins in the blood, the investigators want to understand how inflammation links to the pain. wisdom tooth surgery provides significant post-operative pain and is a widely accepted pain model in drug studies. patients referred for wisdom tooth surgery are asked to participate in the study. for statistical certainty, in total 165 persons will be enrolled to three groups. two with active drug (different dose) and one placebo. everyone gets local anesthesia. the completion of the study will be done in four years. the ethics review board has approved the study. clinical relevance effective pain relief after daily surgical procedures is important for patient´s safety and reducing the risk of long-term pain. it is also ethically necessary for the continued expansion of day case surgery. new knowledge of the mechanisms of pain increases the opportunities for individual and safe pain relief. day case surgery is performed in all operating specialties, this might affects many patients nationally and internationally.


Eligibility criteria:
inclusion criteria: * healthy or mild well-compensated systemic disease (asa i \& ii) * 18- \<45 years * 50-100 kg body weight exclusion criteria: * medication drugs: analgesics, hypnotics (the last week before surgery), thyroid hormones, psychoactive drugs or monoamine oxidase inhibitors (mao inhibitors). * hypertension \[\> 150/95 mmhg in screening study\] * heart failure * psychosis * epilepsy * hyperthyreosis * myasthenia gravis * glaucoma * verified sleep apnea * diabetes (insulin treated) * porphyria * pregnancy * breast-feeding * blood transmitted infections, such as hiv and hepatitis b and c * known hypersensitivity to midazolam, ketamine, ibuprofen, or local anesthetics * inability to obtain the requisite written or oral information

Keywords: ketamine postoperative pain management third molar
effectiveness of pre-administered natural sweet-tasting solution (honey) for decreasing pain of needle insertion

Conditions: Analgesia

Summary: this study aims to assess effectiveness of pre-administered natural sweet-tasting solution (honey) for decreasing pain associated with dental injections (infiltration) prior to dental extraction in 6-8 years old healthy children (first dental visit) in comparison to topical anesthesia.

the administration of local anesthetics is one of the most dreaded or anxiety-inducing triggers in a dental setup. patients, particularly children, may be fearful of dental injections, which may prevent them from seeking dental treatment. even though profound local anesthesia aids in the treatment of pediatric patients in terms of reducing their anxiety and pain during restorative and surgical procedures, the fear of needles has been cited as a barrier to develop proper dental care. numerous techniques have been researched in an attempt to minimize the pain and distress associated with these dental injections, varying from localized methods to distraction techniques. the localized methods include application of topical agents, altering the rate of injection, increasing the ph of local anesthetics by buffering and pretreatment with lasers. instruments such as ccla system (computer-controlled local anesthetic delivery system) and dental vibe are also available to make dental injections more comfortable. studies have found that sweet flavored solutions, mainly 30% sucrose, given orally prior to cutaneous procedures can reduce discomfort in neonates undergoing heel sticks and venipuncture. effectiveness of sucrose in the treatment of, procedural pain in newborns and babies has been verified in a cochrane reviews.

Eligibility criteria:
inclusion criteria: 1. children within the age group 6 to 8 years were selected since the cognitive skills necessary for the use of visual analogue scale for pain assessment have not developed in children younger than 6 years of age. 2. mobile deciduous second molars bilaterally that could be treated under infiltration anesthesia. exclusion criteria 1. history of allergy to any components of local anesthetic agents used during the study. 2. dental or dentoalveolar abscess. 3. presence of any underlying systemic disease. 4. immunocompromised patients.

Keywords: honey injection local anesthesia pain
oral administration of tranexamic acid in anterior cruciate ligament surgery reduce postoperative haemarthrosis

Conditions: Hemorrhage Postoperative; Anterior Cruciate Ligament Rupture; Arthroscopy; Total Blood Loss

Summary: to find superiority relationship between oral and intravenous administration of tranexamic acid on peroperative and postoperative blood loss, haemarthrosis prevalence and improvement functional prognosis in anterior cruciate ligament arthroscopy.

tranexamic acid is an anti-fibrinolytic drug, recommended in total hip arthroplasty to reduce peroperative and postoperative hemorrhagic complications. the original character of our study lies in the serum dosage of tranexamic acid, allowing to correlate the primary objective (blood loss) with this one. the investigators will focus on the reduction of the risks associated with the administration of intravenous medicines, the economic aspect and the ease of use.

Eligibility criteria:
inclusion criteria: * primary arthroscopic surgery for anterior cruciate ligament reconstruction exclusion criteria: * renal failure with serum creatinine level higher than 1,40 mg/dl * thromboembolic events in last 12 months before surgery * pregnancy * congenital or acquired coagulation diseases * history of gastric surgery that could lead to malabsorption * diabetic gastro-paresis
surgical and non-surgical treatment of peri-implantitis

Conditions: Peri-implantitis

Summary: this study will compare surgical and non surgical treatments of peri-implantitis. peri-implantitis is an inflammation around dental implants that can lead to the loss of the implant over time if no treatment is established. the signs of peri-implantitis included bleeding of the gingiva, swelling and redness. most of times there is no pain. patients presenting with these characteristics will be included at random to one of the treatment groups. those allocated to the non-surgical group will received implant cleansing after local anesthesia using adequate instruments. in the surgical group, patients will be submitted to a surgical procedure around the implant for visualization and cleansing also after local anesthesia. all patients will be followed over a 12-month period. the hypothesis is that surgical treatment is better than non-surgical treatment regarding clinical, radiographic, microbiological, and immunological.characteristics.


Eligibility criteria:
inclusion criteria: * individuals with at least one dental implant with peri-implantitits * individuals with good general health conditions; * individuals presenting at least 10 natural teeth; * individuals with no signs of active periodontitis exclusion criteria: * individuals who received periodontal treatment in the last three months * pregnant * systemic condition that interferes with treatment such as diabetes * individuals who are taking or have taken antibiotics or anti-inflammatory medication

Keywords: peri-implantitis dental implants randomized controlled trial non-surgical periodontal treatment will be defined by the presence of alveolar bone loss of at least 3mm, pocket depth of at least 5mm and bleeding on probing.
impact of oligonol to cardiometabolic risk and muscular health

Conditions: Muscle Loss; Muscle Weakness; Quality of Life

Summary: this project will mainly focus on middle and old-aged adults, and examine whether cardiovascular and metabolic risks can be reduced. in the meanwhile, this project will develop strategies for improving muscle loss , muscle strength decline, and the quality life of the elderly.

cardiovascular diseases are common among the elder. however, previous researches mainly focus on observational research or small scale clinical trial, and the subjects are mainly youth. therefore, this project hope to understand whether oligonol can reduce cardiovascular and metabolic risks among senior adults. consequently,improve muscle loss muscle strength decline, quality of old adults life. this project design may potentially develop new strategies for curing sarcopenia as well.

Eligibility criteria:
inclusion criteria: * people who aged more than 50 years * patients with following characteristics: * feeling loss in activity. * detecting decline in self's walking speed. * feeling tired of doing everything. * having fallen down last year. * people can accept undergoing mri * people willing to follow the program and cooperate with us for following tracking. * people who are neither vegan nor vegetarian exclusion criteria: * walking speed less than 0.3m/s * people with any disease affecting their limbs, including: * having fracture on limbs in the past 6 months. * having severe arthritis in the past 6 months * any other whom pi recognized as weak control of their nervous system( e.g.: parkinson's disease and stroke). * people with intermittent limp caused by peripheral artery diseases * people with weak control of mental disorder * people with weak control of cardiopulmonary disease * people with weak control of malignant tumor * people with weak control of kidney diseases (gfr \< 30 ml/min/1.73 m2 for at least 3 months) * people with visual impairment and hearing disorder who cannot complete the program. * people who are unable to undertake mri * any other condition that pi recognized as not suitable.
quality of life of children with sickle cell disease who are getting chronic transfusions with a lifeport

Conditions: Anemia, Sickle Cell

Summary: this study is being done to see what impact having a lifeport device has on quality of life for children with sickle cell who are getting chronic transfusions, from the child's perspective.

there is a paucity of research that focuses specifically on quality of life (qol) among patients with sickle cell. this study aims to explore the qol of children who are receiving chronic transfusion therapy (ctt) using a lifeport device, which allows them to undergo erythrocytapheresis, rather than standard transfusion therapy. erythrocytapheresis is less time consuming and is associated with less iron overload than conventional transfusion therapy; however, little is known about the implications for the child's qol. this study will explore qol from the child's perspective.

Eligibility criteria:
inclusion criteria: * individuals with a diagnosis of sickle cell disease between the ages of 8 \& 18 years * currently receiving chronic transfusion therapy via a lifeport device * individuals have been utilizing the lifeport for at least 6 months and no more than 18 months * individuals have received transfusions previously using conventional transfusion therapy (simple or exchange transfusions) * individuals have permission of parents (when applicable) and assent exclusion criteria: * individuals who, in the opinion of the study staff, would suffer negative consequence, psychosocial trauma, or undue stress as a result of participation

Keywords: chronic transfusion therapy quality of life