Kornimate/medical-research-clean huggingface dataset:
structural and microbiological characterization of endotracheal tube biofilm in patients at increased risk for the development of ventilator-associated pneumonia in the intensive care unit

Conditions: Biofilm Formation; Structural and Microbiological Characterization of Endotracheal Tube Biofilm; Ventilator-associated Pneumonia (VAP)

Summary: ventilator-associated pneumonia (vap) remains the most frequent healthcare-associated infection (hai) in the intensive care unit (icu) and one of the most critical risk factors associated with both significant morbidity as well as mortality. although vap treatment relies on early and appropriate antimicrobial therapy, several preventive measures have been described in the literature in order to limit its incidence and clinical impact in the icu. among these, preventing biofilm formation on the inner surface of the endotracheal tube appears to hold promise. yet there is a lack of clinical relevant data documenting a causal relation between biofilm formation and vap. designed to overcome this critical limitation, the biopavir study intends to provide a better structural and microbiological characterization of endotracheal tube biofilm in critically ill patients at increased risk for the development of vap in icu during covid-19 pandemic.


Eligibility criteria:
inclusion criteria: * patient \> 18 years of age with mechanical ventilation for \>2 calendar days exclusion criteria: * inability to collect or dispatch the endotracheal tube for proper characterization within 24 hours post-extubation
pain after laparoscopic hysterectomy

Conditions: Postoperative Pain

Summary: the investigators evaluated postoperative pain after total laparoscopic hysterectomy. two arm are evaluated. during laparoscopic hysterectomy, in one arm; abdominal cavity was washed by saline at normal room temperature. in another arm; abdominal cavity was washed heated saline . postoperative pain was evaluated by using visual analogy scale.

the aim of this study was evaluated the effect of washing abdominal cavity by heated or normal temperature saline on postoperative pain. this study is double blind randomized controlled study. inclusion criteria: all of cases that had laparoscopic hysterectomy for bening condition exclusion criteria: maling cases and conversion to laparotomy after randomization and completion of surgery, investigator was evaluated postoperative pain at 0-4-8 th hours by using visual analog scale participants and investigator were blinded .

Eligibility criteria:
inclusion criteria: * all of cases that had laparoscopic hysterectomy for bening conditions exclusion criteria: * maling cases * conversion to laparotomy
hypnotherapy to improve coping with stress

Conditions: Stress, Psychological

Summary: this prospective controlled study aims to test a 5 week group hypnosis training as intervention to improve coping with perceived psychological stress.


Eligibility criteria:
inclusion criteria: * healthy or health-stable participants between 18 and 65 years with increased perceived stress for at least 3 months * perceived stress in the last week on the visual analog scale\> 40 mm (vas 0 - 100 mm) * ability to consent and sign declaration of consent exclusion criteria: * current or planned participation in a stress management exercise within the next 17 weeks * current use of psychotherapeutic treatment * presence of moderate or severe acute or chronic disease * presence of an acute or chronic mental disorder * participation in a study within the last 2 months prior to enrollment * lack of understanding of the german language
can dance therapy improve motor learning in parkinson's disease (pd)?

Conditions: Parkinson Disease

Summary: in order to find the most effective rehabilitative therapies for parkinsonian patients, the present study is aimed to evaluate whether, in a multidisciplinary intensive rehabilitation treatment, the dance therapy, applied to the motor learning, promote additional benefits.


Eligibility criteria:
inclusion criteria: * stage 2.5-3 according to the hoehn and yahr scale (h\&y); * stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization; exclusion criteria: * any focal brain lesion detected in brain imaging studies (ct or mri) performed in the previous 12 months; * drug-induced dyskinesias; * disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of updrs iii; * behavioral disturbances (evaluated with neuropsychiatric inventory); * visual and auditory dysfunctions according to the general clinical evaluation and medical history; * cognitive decline (mmse correct score \< 24)
tuina for patients with chronic neck pain

Conditions: Chronic Neck Pain

Summary: the aim is to evaluate whether tuina is more effective and cost-effective than no intervention waiting list to reduce neck pain measured on a visual analogue scale in patients suffering from chronic neck pain.

objective: to evaluate whether tuina is more effective and cost-effective than no intervention waiting list to reduce neck pain measured on a visual analogue scale in patients suffering from chronic neck pain. study design: open single-centre randomized two-armed controlled trial. setting: the study will be performed at a university out-patient clinic specialized in integrative medicine, with experience in the treatment of chronic pain. participants: 88 outpatients with chronic neck pain, who will be randomly allocated to two groups (tuina, or no intervention (control)). intervention: patients receive either six tuina treatments within 3 weeks or no additional intervention. main outcome measure: the primary outcome is the mean neck pain intensity over the last seven days on a visual analogue scale (huskisson, 1974) (vas, 0-100 mm, 0 = no pain, 100= worst imaginable pain) after four weeks.

Eligibility criteria:
inclusion criteria: * female or male * 18 to 60 years of age * clinical diagnosis "chronic neck pain", i.e. neck pain for at least 12 weeks * if additional back pain is reported, neck pain has to be predominant * intensity of the average neck pain over the last 7 days had to be more than 40 mm on a 100-mm visual analogue scale (vas) * ability to give oral and signed written informed consent * patient's mental and physical ability to participate in the trial * willingness to be randomized, to attend visits, to complete questionnaires * written and oral informed consent exclusion criteria: * neck pain caused by a malignant disease * neck pain caused by trauma * rheumatic disorder * prior spinal column surgery * neurological symptoms, e.g. radicular symptoms because of a prolapsed vertebral disc * suspected osteoporosis * obesity with bmi ≥30 kg/m2 * known vascular anomaly such as aneurysm * regular intake of analgesics (\>1x per week) because of a additional diseases * intake of centrally acting analgesics * current application for a benefit * pregnancy * severe acute and or chronic disease which does not allow participation in the therapy * other limitations which do not allow participation in the therapy * alcohol or substance abuse * tuina treatment during the six months before study entry * participation in another clinical trial during six months before the study and parallel to the study * anticipated new treatments which have a positive influence on the neck pain such as physiotherapy against neck pain, acupuncture, massage during the study * no sufficient german language skills

Keywords: neck pain tuina
first-line treatment for hiv-2

Conditions: HIV-2 Infection

Summary: fit-2 is a multi-country, phase iib, randomized, non-comparative study, carried out in west africa (côte d'ivoire, burkina faso, senegal, togo). arv-naïve hiv-2 infected adult patients will be recruited and followed during 96 weeks. the objective is to evaluate the efficacy and safety of 3 first-line treatments in hiv-2 infected adult patients, in west africa. a treatment will be considered as effective if more than 55% of patients in that arm attain "global success" at 96 weeks.

main objective to determine in treatment-naïve hiv-2 infected patients, with cd4 counts above 200 cells/mm3, which of the following three regimens of first line treatment, tenofovir (tdf), emtricitabine or lamivudine (ftc or 3tc) plus zidovudine (zdv); tdf-ftc (3tc) plus lopinavir/ritonavir (lpv / r); or tdf-ftc (3tc) plus raltegravir (ral), will result in an "global success" rate of \> 55% at week 96. number of participants : 210 main outcome : the proportion of patients with "global success" at w96, defined by survival with a plasma hiv-2 rna viral load of \ +100cells/mm3 for initial cd4s between 201 and 500 cells/mm3 or delta ≥0 cells/mm3 for initial cd4s \> +500 cells/mm3) inclusion criteria: * infection by hiv-2 only; * age \> or = 18 years; * naïve for antiretroviral therapy (including antiretroviral treatment in the context of pmtct except taking a dose of nevirapine for pmtct) * cd4 \>200 cells/mm3 * resident of the city where the study is held or of city suburbs to facilitate participation * signed informed consent document

Eligibility criteria:
inclusion criteria: * infection by hiv-2 only; * age \> ou = 18 years; * naïve for antiretroviral therapy (including antiretroviral treatment in the context of pmtct except taking a dose of nevirapine for pmtct) * cd4 \>200 cells/mm3 * resident of the city where the study is held or of city suburbs to facilitate participation * signed informed consent document exclusion criteria: * current participation in any other clinical trial * presence of opportunistic non-stabilized infections, of any serious or progressive disease, or of any clinical signs consistent with severe disease whose diagnosis is not yet confirmed, such as fever, weight loss, diarrhea or cough not yet explained (non-exhaustive list). * all pathology that leads in daily life to prefer one or the other of the three therapeutic regimens for medical reasons or to change the dosages specified in the test. this includes (but not limited to): * hemoglobin ≤ 8 g / dl * neutrophil count \<500 cells/mm3 * renal impairment with creatinine clearance \<50ml/mn * blood platelet \<50 000 cells/mm3 * decompensated heart failure * hepatic failure severe (tp\ 3x uln) * active tb during treatment with rifampicin * taking drugs that interact with the drugs of the clinical trial (as specified in the spc) * pregnancy, breastfeeding or planning to become pregnant during study follow-up

Keywords: africa antiretroviral treatment hiv-2 firsts line art adults
developing imaging and plasma biomarkers in describing heart failure with preserved ejection fraction (diamondhfpef)

Conditions: Patients With Heart Failure and Preserved Ejection Fraction - HFpEF; Patients With Heart Failure With Reduced Ejection Fraction - HFrEF; Healthy Controls Group - Age and Sex-matched

Summary: the investigators wish to test a hypothesis that patients with hfpef have different characteristics on echo, cardiac mri and plasma protein \& chemical profiles compared to hfref and healthy volunteers.

large scale prospective studies incorporating cardiac mri, echocardiography and plasma sampling are currently lacking in hfpef. the main aims of our study are to: 1. better phenotype and characterise hfpef (also comparing with hfref and age- and sex- matched healthy controls) 2. provide mechanistic insights into pathophysiology 3. describe potential biomarkers and their relation to relevant clinical outcomes (exercise capacity, heart failure quality of life and prognosis)

Eligibility criteria:
inclusion criteria: * clinical features of heart failure or prior radiographic evidence in the absence of symptoms and either ejection fraction \> 50% (for hfpef arm) or ejection fraction \< 40% (for hfref arm) exclusion criteria: * myocardial infarction within the preceding 6 months * suspected or confirmed cardiomyopathy (e.g. hypertrophic, infiltrative) * suspected or confirmed constrictive pericarditis * significant native valve disease (≥ moderate severity) * known significant lung disease (documented or fev1\< 30% or fvc \< 50%) * non-cardiovascular co-morbidity likely to cause death within 6 months (e.g. malignancy) * significant renal failure (estimated gfr \< 30 ml/min/m2) * patient inability to provide informed consent (e.g. dementia)

Keywords: hfpef hfref
kinesio tape application in the treatment of plantar fasciitis

Conditions: Plantar Fascitis

Summary: this study is a prospective randomized clinical trial. radial extracorporeal shock wave therapy (r-eswt) is accepted as one of the most effective treatment modalities for plantar fasciitis (pf). kinesio taping (kt) applied to the plantar fascia can provide patients with pf some benefits, but there no enough evidence about this topic. this study analysed the acute effect of adding kt to r-eswt, on pain, foot function and flexibility when treating pf.

the study was performed on 42 patients with unilateral pf, that were randomly assigned into wo groups receiving four sessions of either r-eswt or r-eswt+kt treatment once per week. all patients performed home exercises. patients' pain levels were evaluated via the visual analogue scale (vas), and foot function via the foot function index (ffi). flexibility was assessed through gastro-soleus and plantar fascia flexibility tests. the evaluations were done before and one week after the final treatment.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of unilateral plantar fasciitis, * the presence of a heel spur on a lateral radiograph exclusion criteria: * lower extremity surgeries or traumas, * systemic inflammatory disease, * steroid injections administered within the past six months, * pacemaker usage, * coagulation disorders, * use of anticoagulants.

Keywords: plantar fasciitis radial extracorporeal shock wave therapy kinesio taping pain
biomarker-based algorithm for diagnosis of glioma

Conditions: Glioma

Summary: atrx (x-linked mental retardation and alpha-thalassaemia syndrome protein) loss and ptert (telomerase reverse transcriptase) mutation are diagnostic markers of gliomas. however, 4 to 28% of gliomas shows none of these alterations. the aim of this project is to propose a new test able to detect the telomeric status for every glioma. based on this test and other markers (such as mutation of idh1 (isocitrate dehydrogenase 1) and idh2 (isocitrate dehydrogenase 2)), investigators propose an algorithm, able to classify the main subtypes of gliomas (astrocytoma, oligodendroglioma and glioblastoma).


Eligibility criteria:
inclusion criteria: * patient with a diagnosis of glioma (retrospective), * patient with available biological material : extracted dna and/or ffpe tissue and/or frozen sample. * samples are not required any more for diagnosis purpose * patient with informed consent exclusion criteria: * patient with no informed consent * patients with no available biological sample
the effect of post-operative exercise in gastric cancer patients: a randomized controlled trial (rct) study

Conditions: Gastric Cancer

Summary: medical advancements are enhancing the survival rates of individuals with gastric cancer. the growing population of gastric cancer survivors underscores the importance of managing treatment-related after-effects and side effects. diminished physical function in cancer patients, particularly following gastric cancer surgery, is linked to increased mortality. the substantial decline in physical activity post-surgery contributes to a notable reduction in cardiorespiratory fitness and lower extremity muscle strength. early postoperative exercise has demonstrated positive outcomes in colorectal cancer patients, facilitating early hospital discharge and supporting long-term recovery. however, there is a paucity of research on the efficacy of early postoperative exercise in the context of gastric cancer. therefore, this study aims to evaluate the impact of early postoperative exercise on physical function following gastric cancer surgery.


Eligibility criteria:
inclusion criteria: 1. adult men and women 19 years of age or older 2. pathologically diagnosed gastric cancer 3. able to undergo radical resection (r0) 4. scheduled for minimally invasive surgery (mis) exclusion criteria: 1. pregnant or lactating women 2. have received chemotherapy and radiation before surgery 3. scheduled for open surgery 4. subjects who do not understand or have not given informed consent 5. if healthcare provider (primary care physician) deems it difficult for you to exercise
a study to evaluate clinical characteristics of lung cancer in patients with surgeries and adjuvant therapies

Conditions: Lung Cancer

Summary: the study was designed to evaluate effectiveness of the surgeries and adjuvant therapies after surgeries in the patients with lung malignant tumors

the trial is a multi-centre real-world non-interventional observational study to evaluate effectiveness of the surgeries and adjuvant therapies after surgeries in the patients with lung malignant tumors via a retrospectively review method on the study data on patient demographic/tumor biological characteristics and clinical treatments.

Eligibility criteria:
inclusion criteria: * age \>= 18 years old; * pathologically diagnosed lung malignant tumors after surgeries; * patients with lung surgeries; * patients with complete medical health records and follow-up visit information (at least one follow-up visit); exclusion criteria: * patients who were not performed with surgeries; * pathologically diagnosed patients with benign diseases after surgeries;

Keywords: lung cancer chinese surgeries adjuvant therapies
effects of vitamin d and calcium supplementation on inflammatory biomarkers and adypocytokines in diabetic patients

Conditions: Nutritional and Metabolic Disease

Summary: the epidemic of type 2 diabetes is an enormous public health problem in all parts of the world, with 366 million cases by 2030. chronic inflammation has been postulated to play a role in the pathogenesis of type 2 diabetes. high levels of adiponectin and inflammatory biomarkers are known as a new risk factor for diabetes. there is accumulating evidence suggesting that altered vitamin d and calcium homeostasis affect the development of type 2 diabetes, but it is still unclear whether that effects are through reducing the level of adipocytokines and inflammatory biomarkers or not. this study has been designed to evaluate the effects of vitamin d and calcium supplementations alone and in combination on inflammatory biomarkers and adypocytokines in type 2 diabetic patients. this study is a single masked, controlled randomized trial with period of 8 weeks. 120 diabetic patients who met the inclusion criteria will enroll in this study. subjects will randomly assign in to four groups. randomization will be achieved by permuted blocks with stratification by age, sex, bmi, type of diabetes and dose of medication. group1 will receive 50000 iu of vitamin d3 per week plus calcium placebo, group2 will received 1000 mg of calcium carbonate per day plus vitamin d placebo, group 3 will receive 50000 iu of vitamin d3 plus 100 of mg calcium carbonate per day and group four will receive calcium and vitamin d placebos. total cholesterol, hdl, ldl, serum triglyceride, serum glucose, serum insulin, hba1c, leptin, adiponectin and inflammatory biomarkers such as tnf-alpha, il-6 and high sensitivity c reactive protein (hs-crp) will be determine by taking blood samples at the baseline and at the end of intervention. systolic and diastolic blood pressure and anthropometric measurements (height, weight, hip and waist circumferences) will be measured at the baseline and after 8 weeks of intervention. 3 dietary records and 3 physical activity records will be taken at 2,4 and 6 week of intervention to make sure that all subjects maintain their usual diet and physical activity during intervention.


Eligibility criteria:
inclusion criteria: * more than 30 years old * have no history of renal failure, cancer, liver diseases, thyroid diseases or any other inflammatory diseases * have no allergy * do not use any tobacco products * not using corticosteroids * not consuming any kinds of vitamin d or calcium supplement * have not more than 4 kilograms weight change during last 3 months exclusion criteria: * pregnancy * insulin dependent diabetes

Keywords: cholecalciferol calciol vitamin d3 diabetes mellitus diabetes mellitus type 2 glucose metabolism disorders ergocalciferol calcium adipicytokines inflammatory biomarkers
data mining: precision analytical retrospective data correlation

Conditions: Obesity; Endocrine; Hormone Disturbance

Summary: data from previously analyzed clinical samples tested by precision analytical, inc. will be mined to identify and select samples from patients reporting hormone supplement use. patient demographics (bmi, for example), different therapies and expected changes in hormone levels will be analyzed and hormone metabolite patterns will be compared. samples will be deidentified prior to analysis.

the investigators have a list of 10 estrogen metabolites, 8 androgen metabolites, two progesterone metabolites, 4 cortisol metabolites, free cortisol, six organic acids, 8-hydroxy-2'-deoxyguanosine (8-ohdg), and melatonin that are measured on patient urine samples and cortisol and cortisone on patient saliva samples. the investigators would like to both reinforce the validation of the accuracy of these urinary markers and examine how these markers associate with patient demographics, symptoms, hormone therapy doses and routes of administration. this study will involve analysis of existing data from routine clinical care. all data will be deidentified and each set of results will be given a study id number. the key will be held by danielle martinot and will contain only the original precision analytical sample accession number and the new study id (identification). no identifying phi (protected health information) will be accessible to the pi. these data will be used to evaluate the following hypotheses: 1) urinary hormone measures accurately reflect expected changes in hormones with regard to circadian rhythm, menstrual status, and use of hormonal medications; 2) urinary metabolites of cortisol will show a stronger association with body mass index and symptoms related to cortisol production as compared to salivary measures; 3) urine values of reproductive hormones and organic acids will correlate to the dosing of estrogen and androgens more strongly than to progesterone creams; 4) 8-ohdg, a measure of oxidative stress, and melatonin will be correlated with age and bmi; and 5) urinary hormone measures will capture age-related changes in hormone regulation.

Eligibility criteria:
inclusion criteria: * had testing done at precision analytical between 2016 and 2019 exclusion criteria: * varies by data analysis

Keywords: cortisol cortisol metabolites obesity testosterone estradiol hormone therapy sleep disturbance aging