Kornimate/medical-research-clean huggingface dataset:
comparison of the clinical and microbiological effects of chx and hocl containing mouthwashes

Conditions: Dental Plaque

Summary: the primary objective of the study is to compare the antiplaque and anti-inflammatory effects of hocl mouth rinse with those of chx mouth rinse. the secondary objective is to evaluate and compare the antimicrobial activities of hocl mouth rinse and chx mouth rinse on dental biofilm.

the primary objective of the current clinical study is to compare the antiplaque and anti-inflammatory efficacy of hocl mouth rinse with that of chx mouth rinse. the secondary objective is to compare the antimicrobial activities of these two mouth rinses on dental biofilm. this single-center, triple-blind, randomized controlled crossover study was completed with 26 participants. in the study, the same participants used both hocl (0.02%) and chx (0.2%) mouth rinses over a 4-day re-plaque formation model. following each mouth rinse usage, supragingival dental plaque biofilm samples were collected, and clinical parameters including the modified plaque index, bleeding on probing index, and modified stain index were recorded. additionally, participants were asked to evaluate the mouth rinses they used via a questionnaire. in conclusion, hocl mouth rinse has demonstrated antiplaque efficacy comparable to that of chx mouth rinse. when evaluating total bacterial counts, both mouth rinses exhibited similar antimicrobial effectiveness. within the limitations of this study, hocl may be considered a promising antimicrobial agent for dental plaque control.

Eligibility criteria:
inclusion criteria: * being systematically healthy * having at least 22 natural teeth (236) * not smoking * participants must not drink alcohol and must work during their term exclusion criteria: * having periodontitis and gingivitis * being breastfeeding or pregnant * using medication that may affect periodontal status * having used antibiotics in the last month * having used any mouthwash in the last month * using fixed, removable dentures or orthodontic appliances

Keywords: hypochlorous acid chlorhexidine gluconate antiplaque anti-inflammatory gingivitis
deep enhanced imaging in stroke and vascular neurology

Conditions: Radiology; Cerebral Stroke; Vascular Diseases

Summary: to investigate the performance of enhanced computed tomography (ct) or magnetic resonance (mr) imaging by deep learning relative to conventional ct or mr imaging in brain stroke and vascular neurology. we expect that the deep enhanced imaging method can shorten the time stay in the imaging session of stroke patients, optimize the overall imaging quality and improve the patients' care in imaging session.

early diagnosis of cerebral infarction, detection of ischemic penumbra, evaluation of collateral circulation and identification of vascular lesions by imaging are critical for treatment decision and outcome improvement in cerebral stroke. multimodal computed tomography (ct) and magnetic resonance (mr) imaging are most prevalent and accessible approaches in clinical scenarios. these two approaches are downgraded either by radiation exposure or long scanning time which may hinder the rapid treatment for patients. deep learning has shown substantial achievements in medical imaging enhancement. the added value of deep learning method in stroke and vascular neurology has not been thoroughly validated. in this study, we aimed to investigate the performance of enhanced computed tomography (ct) or magnetic resonance (mr) imaging by deep learning relative to conventional ct or mr imaging in brain stroke and vascular neurology. we expect that the deep enhanced imaging method can shorten the time stay in the imaging session of stroke patients, optimize the overall imaging quality and improve the patients' care in imaging session.

Eligibility criteria:
inclusion criteria: * suspecting to have experienced stroke or cerebral ischemia and needed to undergo brain imaging and vascular imaging including ct or mri * no history of kidney failure * a minimum age of 18 years * obtained written informed consent exclusion criteria: * severe movement artifacts * incidental finding of tumor lesion or craniocerebral surgery history * poor imaging failed to perform deep learning method * women who pregnancy

Keywords: deep learning medical imaging cerebral stroke cerebrovascular disease vascular imaging
state-wide health approach to increase reach and effectiveness: study 1

Conditions: Obesity

Summary: behavioral weight loss programs can successfully reduce body weight, but these programs are available to limited numbers of overweight and obese individuals. this project evaluates a unique weight loss approach that combines a self-sustaining weight loss campaign (for outreach) with training in behavioral weight loss strategies and strategies to increase accountability (to improve weight loss success). this innovative combination has the potential to be a cost-effective model for disseminating weight control interventions.

participants will be randomly assigned to 1 of 3 treatment arms: shape up rhode island (suri; a community-based weight loss campaign), suri plus an internet-based behavioral weight loss program (suri + ibwl), or suri + ibwl + optional group sessions (suri + ibwl + group). primary outcome is weight loss at 12-weeks.

Eligibility criteria:
inclusion criteria: 1. age 18-70 years 2. body mass index \>25 kg/m2 3. both genders will be recruited; it is estimated that 70% of participants will be women. 4. all ethnic groups will be recruited, with a goal of recruiting 33% minorities (see below for specific recruitment plans) 5. no health problems that make weight loss or unsupervised exercise unsafe 6. english speaking exclusion criteria: 1. report a heart condition, chest pain during periods of activity or rest, or loss of consciousness on the physical activity readiness questionnaire (par-q; items 1-4). individuals endorsing joint problems, prescription medication use or other medical conditions that could limit exercise will be required to obtain written physician consent to participate. 2. are currently pregnant or intend to become pregnant in the next 12 months 3. are planning to move outside of the state within the next 12 months 4. have previously participated in the shape up rhode island 2008 pilot study
effect of hemodialysis on upper airways collapsibility in patients with chronic kidney disease

Conditions: Renal Insufficiency, Chronic

Summary: introduction: currently, chronic kidney disease (ckd) is one of the most serious public health problems, becoming a global epidemic. it is also known that the amount of displacement of overnight rostral fluid, from the lower limbs, is related to increased neck circumference and severity of obstructive sleep apnea (osa) in patients with end-stage renal disease. method / design: a clinical trial study aiming to assess the degree of collapsibility of the upper airway in patients with ckd undergoing hemodialysis has been proposed. the test of the negative expiratory pressure and nocturnal polysomnography will be performed before and after the hemodialysis session. discussion: the incidence of ckd has increased, due to the increased number of cases of diabetes mellitus and hypertension. our hypothesis is that the weight gain due to volume overload, observed in the interdialytic period, will exert a negative influence on the degree of collapsibility of the upper airways predispose to osa in ckd patients.


Eligibility criteria:
inclusion criteria: * male or female patients aged 18 to 80 years; * chronic kidney failure; * candidate for kidney transplant with indication for dialysis; * cognitive level sufficient for understanding the procedures and following the instructions; * absence of dementia or treatment-refractory psychiatric diseases leading to an inability to provide informed consent. * and agreement to participate by signing a statement of informed consent. exclusion criteria: * craniofacial abnormalities; * undergoing active treatment of sleep apnea; * active malignancy; * active alcohol and/or drug abuse;

Keywords: chronic kidney disease dialysis sleep pulmonary function polysomnography upper airway
ph i/ii study of subcutaneously administered veltuzumab (ha20) in nhl and cll

Conditions: NHL; Lymphoma, Non-Hodgkin; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Intermediate-Grade; Lymphoma, Large-Cell; Lymphoma, Low-Grade; Lymphoma, Mixed-Cell; Lymphoma, Small-Cell; Leukemia, Lymphocytic, Chronic; Leukemia, B-Cell, Chronic; Leukemia, Prolymphocytic; Leukemia, Small Lymphocytic; Lymphoma, Small Lymphocytic; Lymphoma, Lymphoplasmacytoid, CLL; Lymphoplasmacytoid Lymphoma, CLL; CLL; SLL

Summary: the purpose of this study is to determine if a subcutaneous (sc) dosing schedule of veltuzumab can be established in nhl or cll patients and to confirm the safety and efficacy of veltuzumab that was previously established when administered intravenously.

the first study of veltuzumab given iv weekly in nhl patients (im-t-ha20-01) has shown excellent tolerability and even efficacy at weekly intravenous doses as low as 80-120 mg/m2 over 4 consecutive weeks. these clinical results confirm experiments laboratory studies. laboratory studies using veltuzumab administered subcutaneously showed potent activity based on b-cell depletion. the current study's goal is to determine if a subcutaneous (sc) dosing schedule of veltuzumab can be established in patients with nhl or cll

Eligibility criteria:
inclusion criteria: * histologically confirmed diagnosis of cd20 positive chronic lymphocytic leukemia (cll) * either previously untreated or relapsed * measurable disease (at least one lesion \> 1.5 cm for nhl, or alc \> 5,000 for cll) see full protocol for additional criteria exclusion criteria: * previously untreated nhl patients with stage i and ii disease (ann arbor classification) * previously untreated cll patients with stage 0-2 disease (rai classification) unless specific treatment indications by nccn guidelines exist (symptomatic, recurrent infections, end-organ function, cytopenias and steady disease progression). see full protocol for additional criteria

Keywords: humanized anti-cd20 veltuzumab (immu-106) administered subcutaneously
mindfulness-based reduction stress program

Conditions: Cancer; Caregiver Stress; Quality of Life

Summary: the participants consisted of 1332 caregivers of patients diagnosed with cancer, who applied to atatürk university health research and application center, outpatient chemotherapy unit between december 2022 and march 2023. in the power analysis, the sample of the research; according to cohen, a total of 108 people, 54 of whom were in the experimental group and 54 in the control group, with a medium effect size of 0.5%, an error margin of 0.05% and a confidence interval of 0.95%, were 95% representative of the universe. against the possibility of data loss, 20% backup sample was included in this number and the study was planned with a total of 124 people, 62 in the experimental group and 62 in the control group. 20 participants were excluded on the basis of inclusion and exclusion criteria. 104 participants formed the sample

pretest measurements (t1) were made to the individuals in the experimental and control groups. 8-week mindfulness-based interventions were administered online to caregivers of cancer patients (table 1). before starting the mdi program in the experimental group, visual and written materials about the sessions prepared by the researchers were distributed. the program was implemented 4 days a week, 1 session a day, and each session was implemented in groups of 10-15 people for 60-90 minutes. after the 8-week mdi program of the experimental group was completed, the data collection forms were re-applied to the individuals in the experimental and control groups, and posttest-1 measurements (t2) were made. 4 weeks after the posttest-1 measurements, the posttest-2 measurements (t3) of the individuals in the experimental and control groups were performed.

Eligibility criteria:
inclusion criteria: * no psychiatric problems, * over 18, * literate, * having internet access at home, * not receiving or planning to receive therapy support during the education process, * not having any previous mindfulness experience exclusion criteria: * those who want to leave the study, * do not accept to participate in the research * not at a level to answer the questions asked cognitively.
building electronic tools to enhance and reinforce cardiovascular recommendations - heart failure

Conditions: Heart Failure; Heart Failure With Reduced Ejection Fraction

Summary: this is a feasibility study using a cross-over design to implement and compare a best practice alert (bpa) with an automated in-basket message to inform providers when a patient with heart failure and reduced ejection fraction (hfref) is not on appropriate medical therapy. the data from this pilot study will lead to a randomized controlled trial to compare the effectiveness of the bpa versus an automated in-basket message, versus usual care (no intervention).

an estimated 68,000 deaths per year nationwide can be attributed to gaps in care for patients with heart failure and reduced ejection fraction (hfref), with the majority being due to lack of mineralocorticoid receptor antagonists (mra). despite proven benefits in randomized trials, class i guideline recommendations, and published clinical performance measures, patients with hfref are often not on guideline-directed medical therapy (gdmt). while successful interventions for improvement in prescription of gdmt have often included multidisciplinary approaches with dedicated staff, the relatively high cost of hiring additional personnel has led to an interest in electronic health record (ehr)-based interventions. prior studies on ehr-based interventions in this arena have mainly been conducted in the inpatient setting, which is limited to one encounter during acute hospitalization, a setting often complicated by renal dysfunction or hypotension that can limit prescription of mra. the development and study of outpatient ehr-based alerts for hfref gdmt are needed. two types of outpatient ehr-based interventions include best practice alerts (bpa) and automated in-basket messages. both of these methods have limited data, with some studies showing benefit and others demonstrating provider fatigue and burnout. to our knowledge, there is no study that has directly compared these different types of ehr-based interventions. this is a feasibility study using cross-over design at two outpatient clinics in a large health system to implement and compare a best practice alert (bpa) and an automated in-basket message to inform providers when a patient with heart failure and reduced ejection fraction (hfref) is not on appropriate medical therapy. the data from this study will lead to a randomized controlled trial to compare the effectiveness of the bpa versus an automated in-basket message, versus usual care (no intervention).

Eligibility criteria:
inclusion criteria: * cardiologist visit * transthoracic echocardiogram with the most recent ef \>= 40% exclusion criteria: * hypotension: sbp \< 95 * hyperkalemia: most recent k \> 5.1, or any k \>5.5 * renal dysfunction: egfr \< 30 * ventricular assist device * hospice care

Keywords: best practice alert in-basket message mineralocorticoid receptor antagonists mra guideline-directed medical therapy gdmt
chinese acute tissue-based imaging selection for lysis in stroke -tenecteplase ii

Conditions: Stroke

Summary: to explore the efficacy and safety of tenecteplase for acute ischemic stroke patients (onset time 4.5-24h) of large vessel occlusion using early combined ct/mr imaging outcomes


Eligibility criteria:
inclusion criteria: 1. patients presenting with anterior circulation acute ischaemic stroke 2. time from onset to treatment 4.5h-24h 3. patient's age is \>= 18 years，\<= 80 4. pre-stroke mrs score of \<= 2 5. clinically significant acute neurologic deficit 6. baseline national institute of health stroke scale \>= 6 7. vessel occlusion or severe stenosis ( ica, mca-m1/m2, aca) on computed tomography angiography (cta)/mra 8. multimodal ct/magnetic resonance imaging: perfusion lesion volume (dt \> 3 s) to infarct core volume ratio (rcbf\ 1.2, absolute difference \>10 ml, and ischemic core volume \<70ml 9. informed consent was obtained from patients. exclusion criteria: 1. intracranial hemorrhage or subarachnoid hemorrhage identified by ct or mri 2. rapidly improving symptoms (patient with an nihss score decrease to \< 4 at randomization) 3. pre-stroke mrs score of \> 2 4. contraindication to imaging with ct/magnetic resonance imaging with contrast agents 5. infarct core \>1/3 middle cerebral artery (mca) territory 6. platelet count \< 100x10\^9/l 7. symptoms were caused by low blood glucose \< 2.7 mmol/l 8. severe uncontrolled hypertension, i.e. systolic blood pressure \>= 180 mmhg or diastolic blood pressure \>=100 mmhg 9. current use of warfarin with a prolonged prothrombin time (inr \> 1.7 or prothrombin time \> 15s) 10. use of low molecular weight heparin within 24 hours 11. use of non-vitamin k antagonist oral anticoagulants (noacs) within 48 hours 12. use of glycoprotein iib - iiia inhibitors within 72 hours. 13. arterial puncture at noncompressible site in previous 7 days 14. major surgery in previous 14 days which poses risk in the opinion of the investigator 15. recent gastrointestinal or urinary tract hemorrhage (within previous 21 days) 16. significant head trauma or prior stroke in previous 3 months 17. history of previous intracranial hemorrhage, intracranial neoplasm, arteriovenous malformation, or aneurysm. risks were considered by the investigator 18. hereditary or acquired haemorrhagic diathesis 19. active internal bleeding 20. symptoms suggestive or recent acute pancreatitis, active gastrointestinal ulcer 21. severe liver disease, including liver failure, cirrhosis, portal hypertension and active hepatitis 22. pregnancy or lactation 23. various dying diseases with life expectancy ≤3 months 24. other conditions in which doctors believe that participating in this study may be harmful to the patient 25. patients participated in any trial in 30 days 26. allergic to the test drug and its ingredients

Keywords: acute ischemic stroke large vessel occlusion thrombolysis tenecteplase dosage computed tomography magnetic resonance imaging diffusion weighted imaging early combined imaging outcomes modified rankin scale time window beyond 4.5 hours
sacrocolpopexy and lateral suspension operations

Conditions: Prolapse; Cuff

Summary: different surgical methods can be used in the treatment of vaginal cuff prolapse in patients who had previously undergone hysterectomy for benign reasons. one of these is sacrocolpopexy and the other is lateral suspension. the investigators want to compare the results of patients undergoing these two operations. thus, the difference between surgical methods will be investigated.

patients with symptomatic vaginal cuff prolapse will be operated; there will be two kinds of operation. after the operations, the patients will be followed up, a questionnaire will be applied to the postoperative patients and some questions will be asked. pelvic examinations will also be performed and they will be evaluated for recurrence and complication. at the end of the study, the data of both groups will be compared and their superiority to each other will be shown.

Eligibility criteria:
inclusion criteria: * patients who had previously undergone hysterectomy for benign causes * patients with symptomatic vaginal cuff prolapse during hysterectomy follow-up * and for this, patients scheduled for operation exclusion criteria: * patients with chronic diseases or medications that interfere with the operation * patients with oncology operated for malignant cause * non-localized patients with vaginal cuff prolapse

Keywords: sacrocolpopexy lateral suspension
does stellate ganglion block decrease stress response of intubation?

Conditions: Intubation; Stellate Ganglion

Summary: in this study investigators will evaluate the effect of stellate ganglion block on stress response of intubation in comparison to traditional antistress measures in adult patients

both groups will have the same general anesthesia procedure, patients in stellate block group will receive lidocaine in the stellate block will in control group patients will receive na.cl as placebo. primary outcome will be stress response to subsequent endotracheal intubation measure by changes in heart rate

Eligibility criteria:
inclusion criteria: * elective surgery * general anesthesia with endotracheal intubation * asa i/ii exclusion criteria: * pregnancy * hypersensitivity to local anesthetics * coagulopathy * infection at site of injection * patient refusal
fujifilm dbt plus s-view versus ffdm alone in the detection of breast cancer - a pivotal study

Conditions: Breast Cancer

Summary: the purpose of the pivotal reader study is to assess the comparative accuracy of fujifilm dbt plus s-view versus ffdm in the detection of breast cancer.

this clinical research is a retrospective, pivotal, multi-reader, multi-case (mrmc) study with an enriched sample of 300 breast screening or diagnostic cases which were selected from the library of mammograms collected under fujifilm protocol fmsu2013-004a (all subjects previously provided written informed consent agreeing their image data and supporting documentation could be used for future research and investigations). approximately 18 qualified radiologists will independently perform two reads on all (approximately 300) cases. each reader will read each case both as a ffdm read, and a dbt plus s-view read on the aspire bellus ii workstation. as its primary endpoint, this study is designed to evaluate whether the area under the receiver operating characteristic (roc) curve (auc) based on probability of malignancy (pom) scores and requiring correct lesion localization is statistically non-inferior for dbt plus s-view versus ffdm.

Eligibility criteria:
inclusion criteria: * •female subjects participating in fmsu2013-004a protocol with known clinical status exclusion criteria: * •female subjects that did not have known clinical status in fmsu2013-004a