Kornimate/medical-research-clean huggingface dataset:
impact of ultraviolet radiation and environmental factors on human ocular biomechanics

Conditions: Myopia

Summary: this observational study aims to explore whether ultraviolet (uv) radiation and other environmental factors are associated with ocular biomechanical properties in healthy volunteers aged 18-44 years without ocular diseases, ocular surgery history, or systemic diseases. the main questions it aims to answer are: is there a significant correlation between uv radiation levels and corneal biomechanical parameters? do environmental factors such as geographic region and seasonal variation affect corneal biomechanical behavior? researchers will compare ocular biomechanical parameters among populations from different geographic regions with varying levels of uv radiation to determine whether there are statistically significant correlations or differences. participants will: undergo standardized ophthalmic examinations, including visual acuity, intraocular pressure, slit-lamp evaluation, axial length, and corneal topography; receive corneal biomechanical assessments using the corvis st device; provide basic demographic information and medical history; have all data de-identified, with the study strictly following ethical approval and privacy protection protocols.


Eligibility criteria:
inclusion criteria: * inclusion criteria age between 18 and 44 years (based on who criteria); spherical equivalent refraction (ser) ≤ 6.00 diopters; no other ocular diseases; no systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases); no severe psychiatric or psychological disorders; no history of ocular surgery. exclusion criteria severe psychiatric disorders; individuals diagnosed with keratoconus, suspected keratoconus, or subclinical keratoconus (based on the global consensus on keratoconus diagnosis); presence of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis); history of intraocular or ocular surface surgeries; presence of nystagmus or inability to cooperate with examinations; history of intraocular surgery; presence of systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases). exclusion criteria: * severe psychiatric disorders; individuals diagnosed with keratoconus, suspected keratoconus, or subclinical keratoconus (based on the global consensus on keratoconus diagnosis); presence of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis); history of intraocular or ocular surface surgeries; presence of nystagmus or inability to cooperate with examinations; history of intraocular surgery; presence of systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases).
propofol and remifentanyl versus midazolam and fentanyl for diagnostic colonoscopy in patients with compensated cirrhosis child a-b

Conditions: Liver Disease

Summary: this is a prospective, randomized-controlled trial (rct) comparing the use of propofol and remifentanyl and traditional sedation (midazolam and fentanyl) for diagnostic colonoscopies in patients with compensated cirrhosis child a-b. the working hypothesis is that the use of propofol will be translated in a shorter recovery and discharge times with a higher patient satisfaction and a decrease in general complications (hepatic encephalopathy) in the context of patients with advanced liver disease.


Eligibility criteria:
inclusion criteria: * consecutive patients older than 18 and younger than 75 years with cirrhosis defined by the presence of liver fibrosis at least f3 and higher in the metavir score or with established cirrhosis (child pugh a, b) exclusion criteria: * patients with significant cardiorespiratory disease i.e. advanced respiratory, renal and heart failure (asa class iii or higher except for patients with decompensate liver cirrhosis), obstructive sleep apnea. * hcc

Keywords: endoscopies liver diseases propofol midazolam and remifentanyl
biomarkers for postoperative myocardial infarction in cardiac surgery.

Conditions: Myocardial Infarction

Summary: myocardial infarction and subsequent myocardial injury after cardiac surgery occurs in 7-15% of patients undergoing cardiac surgery and is associated with an increased length of stay, and reduced short- and long-term survival. cardiac troponin is considered to be a cornerstone in the diagnosis of a myocardial infarction. heart-type fatty acid-binding protein (h-fabp) is a new sensitive biomarker for myocardial injury. the effectiveness of using the combination of h-fabp with troponin to diagnose myocardial injury within 6 hours after the onset of ischemia is well reported. previous studies in non-surgical patients have associated increased h-fabp with an increased risk of subsequent death and major cardiac events. the prognostic value in cardiac surgery patients has not been studied extensively. the objective is to estimate the association between biomarkers of myocardial injury and myocardial infarction in patients undergoing cardiac surgery. myocardial infarction will be established with both a new and very early marker of myocardial injury (heart-type fatty acid binding proteins) as well as to a known early marker of such injury (cardiac troponin).

specific aims: 1. to obtain an estimate of the association between a new very early marker of postoperative myocardial injury h-fabp and postoperative myocardial infarction. 2. to obtain an estimate of the association between ctn-i and postoperative myocardial infarction. 3. to obtain an estimate of the correlation between h-fabp elevation and ctn-i elevation in patients undergoing cardiac surgery.

Eligibility criteria:
inclusion criteria: * 18 years or older * isolated coronary artery bypass grafting * isolated valve surgery * combined coronary artery bypass grafting and valve surgery exclusion criteria: * emergency surgery patients * (suspected) sepsis * pulmonary embolism * renal failure (glomerular filtration rate \< 40 ml/min) * off pump cardiac surgery

Keywords: myocardial infarction cardiac surgery troponin heart-type fatty acid binding protein
modified dantien salee yoga training program in chronic obstructive pulmonary disease rehabilitation

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: copd patients will be recruited and assigned into one of each group: 1) control group or 2) yoga group. in yoga groups, subjected will be asked to participate in modified dantien yoga training for 12 weeks (3 times/week, 60 min/time). the subjects will be evaluated their pulmonary function, functional fitness performance, dyspnea score, and quality of life at baseline and after 12 wk training.


Eligibility criteria:
inclusion criteria: 1. stable copd patients \> or equal 6 weeks. 2. age \> or equal 50-80 years. 3. fev1 \> or equal 30% predicted after take bronchodilators drug. 4. resting spo2 \> or equal 90% room air. 5. did not pulmonary rehabilitation program before start the yoga exclusion criteria: 1. subjects with musculoskeletal disorders, mental and neurological disorders, and acute coronary heart disease. 2. blood pressure (systolic) \> 180 mmhg.

Keywords: yoga copd rehabilitation
arm-hand boost program during inpatient rehabilitation after stroke

Conditions: Stroke

Summary: a pilot cross-over rct including participants with sub-acute stroke is conducted in an inpatient rehabilitation setting. the experimental group (eg) receives an arm-hand boost program on top of their usual care program. the control group (cg) receives a dose-matched program of strengthening exercises for the lower limbs and general reconditioning. after 4 weeks, a cross-over is performed. before, after 4 weeks and after 8 weeks of additional therapy, different clinical outcome measures for the upper limb are administered.


Eligibility criteria:
inclusion criteria: * first stroke, as defined by who, * minimal stay of 4 weeks in inpatient setting at study start * minimally 18 years old * being able to sit independently (trunk control test, item 3 = 25), * motor impairment in the upper limb (fugl-meyer assessment, stage 2 (synergies): 8-17p, or stage 2: \ 6p * sufficient cooperation to perform intervention and evaluations exclusion criteria: * musculoskeletal and/or other neurological impairments with permanent damage that may hinder the study * subdural hematoma, tumor, encephalitis, trauma, or other that lead to similar symptoms as stroke * severe communication, cognitive or language impairments that hinder the investigations * no written informed consent
tonsillectomy in recurrent tonsillitis

Conditions: Tonsillitis

Summary: the purpose of this study is to determine whether tonsillectomy is effective in preventing further streptococcal pharyngitis episodes in patients with recurrent tonsillitis.

tonsillectomy is widely used worldwide in recurrent streptococcal tonsillitis, but its effect remains unknown. in this randomized controlled trial, the effect of tonsillectomy (compared to watchful waiting) in preventing further culture proven symptomatic streptococcal pharyngitis episodes is studied. in addition, symptoms after the operation, side effects, and life quality issues are recorded.

Eligibility criteria:
inclusion criteria: * at least 3 tonsillitis episodes during the preceding year (at least one verified by culture or antigen testing) exclusion criteria: * other serious illness * long term antibiotic treatment for other disease * documented immunologic disorder * pregnancy

Keywords: recurrent tonsillitis streptococcus tonsillectomy prevention
in-home weight loss program for adults with type 2 diabetes delivered by interactive cable television technology

Conditions: Diabetes Mellitus, Type 2

Summary: the majority of patients with type 2 diabetes are obese and weight loss is known to improve diabetes outcomes and reduce the need for anti-diabetic medical. this 8-week telehealth study will compare the effects of standard weight loss advice given in a clinic setting to weight loss advice delivered in the home using an interactive cable television technology called healthium.

the majority of patients with type 2 diabetes are obese and weight loss is known to improve diabetes outcomes and reduce the need for anti-diabetic medical. the overall goal of this study is to explore the human engineering issues of a home (non-clinical) telehealth system, healthium, utilizing an interactive television system over a broadband connection. the study seeks to demonstrate a convenient, intuitive and inexpensive way to conduct large-scale interventions related to obesity and nutrition. this could lead to a viable public health care initiative for prevention of chronic diseases such as diabetes. the specific aims to be addressed are aim #1: to transfer a successful internet-based weight loss program onto the healthium interactive platform and further develop the intervention for use in patients with type 2 diabetes. aim #2: to conduct focus groups to determine consumer acceptability of the convenience and intuitiveness of the healthium interface. aim #3: to perform a pilot study in patients with type 2 diabetes to determine whether the healthium interface improves weight loss and diabetes outcomes relative to standard clinic-based treatment over a period of 8 weeks.

Eligibility criteria:
inclusion criteria: clinical diagnosis of type 2 diabetes, body mass index 25-35; ability to read at 8th grade level, have a working television set in the household, be willing to complete daily exercise and diet logs for the 8-233k study; be willing to attend at least 3 clinic visits; under care of physician for diabetes - exclusion criteria: evidence of cardiac, renal, or other endocrine diseases; clinical evidence of a substance abuse or mental illness; pregnancy or anticipated pregnancy; breastfeeding; excessive alcohol consumption; anticipated major lifestyle changes -

Keywords: telemedicine biobehavioral weight loss program body mass index blood glucose diabetes management
uptake of telemedicine system trial in rual canton

Conditions: Diabetes Retinopathy; Diabetes Macular Edema

Summary: to evaluate the impact of telemedicine system in rural hospitals for diagnosis and treatment of diabetes retinopathy and diabetes macular edema.

telemedicine system mainly contains a comprehensive eye examination electric-records (e-record), which can transfer the fundus pictures from rural hospitals to professional graders (golden standard for a diagnose of diabetes retinopathy (dr) and diabetes macular edema(dme)). in zhongshan ophthalmic center (zoc). by this system, the investigators can evaluate the capacity of rural eye doctors about the diagnosis of dr/dme, and give proper suggestions for the treatment and revisit plan.

Eligibility criteria:
inclusion criteria: * age \> 40y, diagnosed (diabetes retinopathy) dr,10% normal patients exclusion criteria: * unconsciousness, history of diabetic ketoacidosis, cardiac insufficiency, severe atrioventricular block, hepatic insufficiency , allergic to mydriatic

Keywords: sensibility specificity positive predictive value negative predictive value cost-effectiveness
enantyum® iv versus piroxen® im in emergency pain management

Conditions: Traumatic Injury

Summary: for pain of traumatic origin, the rice protocol (rest, ice, compression, elevation) is the main therapeutic measure during the first 4 to 5 days post-trauma. however, there is currently insufficient evidence that this protocol is effective \[4\]. in the emergency department, paracetamol, nsaids or a combination of several molecules are generally prescribed. patients even use these drugs without a prescription. the aim of this study is to compare the effect of dexketoprofen® iv versus piroxen® im in the treatment of pain in emergency departments.

this was a prospective, randomized, double-blind, controlled study conducted at the sahloul emergency department, sousse. study duration: 3 months. inclusion criteria: patients over 18 years of age requiring analgesia for acute pain of traumatic origin and who signed a written consent form were included in this study. exclusion criteria: patients who meet the following conditions: * refusal, incapacity, difficulties with consent or communication * patients with chronic pain. * any known allergy or secondary reaction to piroxen or dexketoprofen trometamol. * pregnant women. * cirrhosis of the liver. methodology: 1. dexketoprofen group patient receives an intravenous injection of dexketoprofen + im placebo + follow-up sheet + appointment card. 2. piroxican group. patients receive one intramuscular piroxen injection + iv ssi infusion + follow-up sheet + appointment card. for each patient included, vas, blood pressure, heart rate, respiratory rate and sa02 are taken on admission and discharge from the emergency department, and at the second telephone visit after 07 days. at the 7th day visit (by telephone), patients were asked to answer satisfaction questions and complete the eq50 quality of life questionnaire.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age who required analgesia for acute pain of traumatic origin and who signed a written consent form were included in the study. exclusion criteria: * patients who meet the following conditions: * refusal, incapacity, difficulties with consent or communication * patients with chronic pain. * any known allergy or secondary reaction to piroxen or dexketoprofen trometamol. * pregnant women. * cirrhosis of the liver.
evaluation of the national treatment program of hepatitis c in egypt

Conditions: Chronic Hepatitis C

Summary: the aim of the study is to analyse data coming from two treatment centres of the national treatment program centres of hepatitis c in egypt

analyse data coming from two centres of the national treatment program of hepatitis c in egypt: * 1500 patients who started treatment between april 1st 2013 and march 31st 2014 and will be seen for their week 60 visit between july 1st 2014 and june 30th 2015 (cohort a). * 1000 patients recruited between july 1st 2014 and estimated march 31st 2015, of which 200 are expected to be early defaulters and will be contacted by the study team (cohort b).

Eligibility criteria:
inclusion criteria: * age \ 60 years * positive hcv antibodies using a third generation test * detectable hcv rna by pcr * liver biopsy showing chronic hepatitis with either a metavir score f1 with elevated liver enzymes or scores f2/f3 * naïve to treatment with peg-ifn and rbv * hbs antigen negative * prothrombin time ≥60 %, normal bilirubin, alpha-foeto protein \< 3\*normal range of the laboratory, anti-nuclear antibodies\<1/160 * effective contraception during the treatment period; no breast-feeding * signed informed consent and willingness to participate in the study exclusion criteria: * serious co-morbid conditions such as severe hypertension, heart failure, significant coronary heart disease, poorly controlled diabetes (hba1c\>8%) , chronic obstructive pulmonary disease * major uncontrolled depressive illness * solid transplant organ (renal, heart, or lung) * untreated thyroid disease * history of previous anti-hcv therapy * body mass index (bmi) greater than 30 kg/m² * known human immunodeficiency virus (hiv) coinfection: although hiv testing will not be proposed or done, patients with known hiv coinfection will not be included in the trial * hypersensitivity to one of the two drugs (peg-ifn, rbv) * pregnancy or unwilling to comply with adequate contraception * breast-feeding * neutropenia (\<1500/mm3) * anaemia (\<11g/dl for women ; \<12g/dl for men) * thrombocytopenia (\<100.000/mm3) * elevated creatinin (\>1.5mg/dl) * concomitant liver disease other than hepatitis c (immuno-active chronic hepatitis b, autoimmune hepatitis, alcoholic liver disease, hemochromatosis, alpha-1 antitrypsin deficiency, wilson disease) * liver biopsy showing severe steatosis (\>66%) and steatohepatitis; decompensated cirrhosis (child pugh\>a); hepatocellular carcinoma, metavir score f4. * tsh\>5 mu/l

Keywords: viral hepatitis c genotype 4 svr egyptian national program
diffusion tensor sequences (dti) for study of lumbar roots by magnetic resonance imaging (mri)

Conditions: Radiculopathy Lumbar; MRI; Diffusion Tensor Imaging

Summary: diffusion tensor imaging (dti) is a non-invasive mri technique offering a functional approach that provides morphological information about the microstructures of the nerve roots. dti is a widely used neuroimaging technique and is a current topic of research in the field of peripheral nerve imaging. the aim of this work is therefore to improve dti sequences by specifically evaluating the contribution of the multiband technique in healthy volunteers.

for every healthy volunteer will be acquired: * a morphological sequence * a reference diffusion tensor sequence covering three lumbar stages (reference dti), * a diffusion tensor sequence acquired in multiband technique, covering three lumbar stages (optimized dti), * a diffusion tensor sequence acquired in a multiband technique, covering a lumbar stage, of higher spatial resolution (centred dti)

Eligibility criteria:
inclusion criteria: * person without history of lumbar surgery * person who has previously consented exclusion criteria: * mri contraindications (pace maker, cardiac defibrillator,...) * claustrophobia * pregnant woman * person without social security * person with a guardianship * person carrying metallic surgical material (spine, pelvis, abdomen)

Keywords: radiculopathy lumbar mri diffusion tensor imaging multiband technique
a study to look at the health outcomes of patients with covid-19 and influenza.

Conditions: COVID-19; Coronavirus Disease 2019; Influenza

Summary: the main purpose of this study is to understand: * the symptoms of covid-19 or influenza * health-related outcomes of people with covid-19 or influenza * the effects of vaccines in people with covid-19 or influenza. this study will take in participants who are: * 18 years or older * reported to have symptoms with lab tests that have confirmed illness. the lab tests can be tested at any of walgreens pharmacy covid-19 or influenza test sites. the study will collect vaccine history information from participants who are ready to take part in the study. participant will be emailed a form with questions about their health related to covid-19 or influenza during twelve follow-ups over a 6-month period.

this is a prospective non-interventional longitudinal cohort survey study. repeated measures on pros: symptoms (prevalence, frequency, duration, and severity), eq-5d-5l, wpai and promis-fatigue short form 8a over 6 months will be collected and evaluated. covid-19 cohort: participants 18 years or older with laboratory-confirmed covid-19 illness and at least one patient-reported symptom. influenza cohort: participants 18 years or older with laboratory-confirmed influenza illness and at least one patient-reported symptom. all study objectives and outcomes will be assessed separately for the two study cohorts.

Eligibility criteria:
inclusion criteria: * age 18 or older * self-reported at least one symptom in the screening questionnaire * positive result reported from the laboratory * evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study * able to complete the questionnaires by themselves in english exclusion criteria: * positive result for both covid-19 and influenza (coinfection) * covid-19 test is done with non-rt-pcr methods such as a rapid antigen test or antibody test

Keywords: patient-reported outcomes humanistic burden quality of life disease symptoms assessment covid-19 sars-cov-2 severe acute respiratory syndrome coronavirus 2 infection acute respiratory infection influenza human influenza
mr-hifu for bone metastases

Conditions: Cancer; Bone Metastases

Summary: the aim of this study is to evaluate effectiveness of the philips sonalleve mr-hifu device for the palliation of pain in patients with bone metastases. magnetic resonance imaging-guided high intensity focused ultrasound (mr-hifu) uses ultrasound to palliate pain caused by bone metastases. the main palliative mechanism of the method is due to local bone denervation, caused by the heat denaturation of the periosteum layer in the treated area. the importance of this therapy is that it offers a non-invasive, focal therapy, avoiding side-effects to surrounding normal tissue that occur with radiation therapy or the need for needle insertion as with radio-frequency(rf)ablation. the study hypothesis is that mr-hifu will be effective in treating the pain associated with bone metastases


Eligibility criteria:
inclusion criteria: * radiologic evidence of bone metastases from any solid tumour * diagnosis of dominant painful bone metastasis * target lesion less than 8cm exclusion criteria: * primary bone tumours rather than metastases * inability to tolerate stationary position during treatment * pregnancy * mri incompatible metal implants

Keywords: magnetic resonance imaging (mri) high intensity focused ultrasound (hifu)