Kornimate/medical-research-clean huggingface dataset:
changes in unstable ankles after balance training

Conditions: Ankle Injury

Summary: this study is evaluating reflex board training to see if it will help people who frequently roll their ankles. we are investigating several tests that evaluate the ability of the neuromuscular system to control ankle movement. this study is in 2 parts:part 1 looks at changes after 1 day of reflex training; part 2 looks at changes after 6 weeks of reflex training. it is thought that the reflex training will improve measures of static and dynamic balance as well as spinal reflex measures.

research has utilized multiple measures in an effort to detect chronic ankle instability (cai). recently, investigations have focused on assessment of sensorimotor function in those who suffer from cai. these measures have included traditional and functional postural control variables, as well as measures of joint position sense, neuromuscular control and recruitment, and nerve conduction velocity. this study seeks to modulate sensorimotor measures through both short- and long-term reflex training. this information may help to better assess sensorimotor deficits associated with cai, to focus future research, evaluate rehabilitation protocols and to improve our understanding of this chronic disability.

Eligibility criteria:
inclusion criteria: * chronically unstable ankles with a history of at least 2 ankle sprains in the past year, m/f 18-30, healthy exclusion criteria: * ankle sprain within past 6 months, any chronic lower extremity injury or condition, neurological condition, balance-inner ear or vestibular condition, any other condition that would interfere with testing

Keywords: ankle sensorimotor reflex training
cardiometabolic profiles of boys with klinefelter syndrome

Conditions: Klinefelter Syndrome; 47,XXY; Sex Chromosome Aneuploidy; XXY Syndrome

Summary: this study plans to learn more about how to measure the way the the body's energy system works in boys with klinefelter syndrome, including the heart, lungs, muscles, and liver. this is important to know so that investigators understand how hormones and an extra x chromosome relate to diseases such as diabetes, extra weight gain, heart disease and liver diseases.

klinefelter syndrome (ks) is the most common chromosomal abnormality in males and is associated with primary gonadal failure in adolescence and a high morbidity and mortality from cardiovascular-related diseases (cvd) in adulthood. recent studies in children and adolescent boys with ks have found a high prevalence of cvd risk markers, however the underlying mechanisms have not been explored. our central hypothesis is that pubertal boys with ks have relative testosterone deficiency resulting in abnormal energy metabolism that predisposes them to later cvd, and that exogenous testosterone will modify these abnormalities. in this study, investigators will measure markers of cardiometabolic risk in pubertal boys with ks.

Eligibility criteria:
inclusion criteria: * male, 47,xxy karyotype (non-mosaic) * age 12-17 years * tanner stage 3-5 pubic hair * t naïve group only: no exogenous androgen exposure within the past 5 years * t exposed group only: currently on topical testosterone, with duration of treatment between 1-2 years. exclusion criteria: * cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures * mri incompatible metal * diagnosis of type 1 or type 2 diabetes * hypertension greater than 140/90 mm/hg at rest (would make exercise studies unsafe) * weight \> 300 lbs (limit for dexa) * testosterone treatment for \ 2 years

Keywords: klinefelter syndrome xxy sex chromosome aneuploidy sex chromosome variation hypogonadism cardiometabolic body composition exercise capacity
the effectiveness of parent-child interaction therapy (pcit)

Conditions: Behavior Problems; Oppositional Defiant Disorder; Conduct Disorder

Summary: the purpose of this study was to investigate whether a type of parent-based intervention, parent-child interaction therapy will lower symptoms of behavior problems in young children more than treatment as usual.

behaviour problems, i.e. symptoms of oppositional defiant disorder (odd) and conduct disorder (cd) are among the prevalent psychiatric disorders in children and one of the leading causes of help-seeking for mental health problems in children. there are several efficacious treatments for such problems in young children. however, most of these require that parents meet in groups. this is not always feasible. it is therefore a need to develop treatments that can deal with parents and families individually. parent-child interaction therapy (pcit) is such an individually based treatment. efficacy studies indicate symptom reduction greater that in treatment as usual (tau). however, there is a need to study its effectiveness in ordinary clinical practise. this trial will study its effect in ordinary psychiatric clinics in the middle of norway and compare it to the regular treatment (tau) provided to young children with behavior problems in these clinics.

Eligibility criteria:
inclusion criteria: * referred to child mental health specialty clinic for behavioral or attentional/hyperactive problems * ecbi score of \> 120 * 2 to 7 years of age * parental consent to the study exclusion criteria: * psychosis or serious drug abuse in parents * lack of sufficient proficiency in norwegian to fill in the questionnaires * mental retardation or pervasive developmental disorder in the child * suspicion of parental neglect or abuse of the child warranting a report to the child protection services

Keywords: behavior problems parent-child interaction locus of control psychiatric symptoms depressive symptoms attachment
peek and allograft spacers evaluation in spinal fusion surgeries

Conditions: Degenerative Disc Disease

Summary: purpose the primary purpose of this study is to prospectively compare clinical and radiographic clinical outcomes in patients undergoing cervical or lumbar interbody fusions and randomized to receive either polyetheretherketone (peek) or cortical allografts.

following surgery study subjects will be evaluated at the following intervals: 3 (+/- 2 weeks), 6 (+/- 1 month), 12 (+/- 2 months), 24 (+/- 2 months) months.

Eligibility criteria:
lumbar fusion patient group inclusion criteria: * skeletally mature adults between 18 and 70 years old * patients with back and leg pain due to degenerative disc disease, scheduled for tlif/plif approach utilizing an interbody spacer and supplemental posterior fixation at 1, 2 or 3 adjacent levels * unresponsive to conservative care over a period of at least 6 months or has progressive neurological signs and/or symptoms of neurological compromise that mandate urgent surgical intervention * willing and able to comply with the requirements of the protocol including followup requirements * willing and able to sign a study specific informed consent. exclusion criteria: * more than 3 intervertebral levels to be fused * posterior fixation used at more than 1 level for 1-level intervertebral fusion * posterior fixation used at more than 2 levels for 2-level intervertebral fusion * posterior fixation used at more than 3 levels for 3-level intervertebral fusion * any additional approaches, e.g. anterior, xlif * active local or systemic infection * prior interbody fusion surgery at the index level * prior fusion at the adjacent levels * previous known allergy to polyetheretherketone (peek) or titanium alloy cervical fusion patient group inclusion criteria: * skeletally mature adults between 18 and 70 years old * patients with neck and/or arm pain due to degenerative disc disease, scheduled for acdf approach utilizing an interbody spacer and anterior cervical plate at 1, 2 or 3 adjacent levels * completed at least 6 weeks of conservative therapy or has progressive neurological signs and/or symptoms of neurological compromise that mandate urgent surgical intervention * willing and able to comply with the requirements of the protocol including followup requirements * willing and able to sign a study specific informed consent exclusion criteria: * more than 3 vertebral levels to be fused * any additional approaches, e.g. posterior cervical fusion * active local or systemic infection * prior interbody fusion surgery at the index level * prior fusion at the adjacent level * previous known allergy to polyetheretherketone (peek) or titanium alloy

Keywords: degenerative disc disease spinal stenosis herniated disc
fatigue in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra) is a disease characterized by autoimmune systemic inflammatory polyarthritis, particularly affecting the joints of the hands. in addition to joint findings, extra-articular symptoms such as muscle pain, fatigue, fever and malaise are also common. fatigue is characterized by a feeling of extreme tiredness and persistent exhaustion. the prevalence of fatigue is between 14% and 15% in healthy adults. although fatigue is common in patients with ra, it may remain in the background in clinical evaluation. the etiology of fatigue in ra is related to inflammation, pain, psychosocial factors and sleep disturbance, it has not been fully explained.

rheumatoid arthritis (ra) is a disease characterized by autoimmune systemic inflammatory polyarthritis, particularly affecting the joints of the hands. in addition to joint findings, extra-articular symptoms such as muscle pain, fatigue, fever and malaise are also common. fatigue is characterized by a feeling of extreme tiredness and persistent exhaustion. the prevalence of fatigue is between 14% and 15% in healthy adults. although fatigue is common in patients with ra, it may remain in the background in clinical evaluation. the etiology of fatigue in ra is related to inflammation, pain, psychosocial factors and sleep disturbance, it has not been fully explained. there are various studies in the literature examining fatigue and factors associated with fatigue in patients with ra. this study aimed to contribute to the literature by determining the relationship of fatigue with physical function, pain values at rest and in motion, gender, age, pain, disease activity, gender and disease duration in ra patients.

Eligibility criteria:
inclusion criteria: * age between 16-85 years * patients diagnosed with ra according to 2002 acr-eular ra criteria. exclusion criteria: * malignancy * neurological disease * major psychiatric disorder * thyroid disease * anemia and hypovitaminosis

Keywords: fatigue disease activity rheumatoid arthritis
the effect on mucosal healing with pentasa sachet in mild to moderate active "drug: crohn's disease"

Conditions: Crohn's Disease

Summary: the purpose of this study is to visualize the healing effect on mucosal lesions with pentasa sachet 4g in patients with mild to moderate active small bowel cd by video capsule endoscopy.

the purpose of this study is to visualize the healing effect on mucosal lesions with pentasa sachet 4g in patients with mild to moderate active small bowel cd by video capsule endoscopy

Eligibility criteria:
4.2 inclusion criteria 1. patients who have signed the informed consent form 2. patients with performed complete vce \< 7 days prior to inclusion and diagnosed clinically active mild to moderate small bowel cd and no stricture on previous examinations, as previously proven by barium small bowel follow through, enteroclysis and / or patency test capsule. 3. patients between 18 - 70 years of age. 4.3 exclusion criteria 1. patients with evidence of other forms of inflammatory small bowel bowel disease, idiopathic proctitis or infectious disease. 2. patients with known small bowel strictures from previous examinations with for instance barium small bowel follow through, enteroclysis and / or patency capsule test. 3. patients with pacemaker due to lack of vce interaction data. 4. patients who cannot undergo study procedures due to swallowing disorders. 5. planned or actual pregnancy or lactation. 6. women of child-bearing potential who are not using an effective method of contraception, in the opinion of the investigator. 8. patients receiving maintenance treatment (p.o.) with total daily doses above 2.0g of sulphasalazine, mesalazine or 4-asa, for 30 days prior to entry into the study. 9. chronic use of non-steroidal anti-inflammatory drugs (oral and/or rectal routes) in 30 days prior to inclusion in the study (chronic use is defined as drug intake for a minimum of 3 consecutive days). 10. intake of corticosteroids (oral and/or rectal routes) within the 30 days prior to enrolment in the study. 11. patients receiving any immunosuppressive (azathioprine, 6-mp, etc) agents during 30 days prior to study enrolment. 12. patients receiving any crohn specific biological agents (tnf-alfa) during the last year prior to study enrolment. 13. patients with any other disease or condition which may interfere with study assessments as judged by the investigator. 14. alcoholism or drug addiction. 15. patients participating or having participated in another clinical study in the previous 30 days. 16. patients with severe renal/hepatic impairment (see section 5.6) as judged by the investigator. 17. patients who are allergic to salicylate or 5-asa derivatives. 18. patients who are unlikely to comply with the protocol. 19. any patient who has previously taken part in this study. 20. patients who are unable to write or read local language
anesthesia lumbar puncture in children

Conditions: Spinal Puncture; Anesthesia

Summary: the study is carried out in a prospectively randomly controlled way. in the context of acknowledgement and understanding from parents, by comparing with traditional process(no anesthesia), lidocaine surface anesthesia is randomly selected. all children will be evaluated by the flacc (the face, legs, activity, cry, consolability behavioral tool) scale to quantitatively assess degree of pain during lumbar puncture. time and success rate of the lumber puncture will be recorded and analyzed. a questionnaire about bad memory during lumbar puncture for all parents and children will be investigated in order to establish an optimized lumbar puncture management process.

the purpose of this study is to establish an optimized lumbar puncture management process on the basis of fully understanding of parents and children. an improved process consisting of painless lumbar puncture (lp) and comfortable lp will be established upon completion of this study.

Eligibility criteria:
inclusion criteria: * children with indications of lumbar puncture; * voluntarily signed the informed consent exclusion criteria: * topical anesthetic skin allergies; * skin infection in lumbar puncture site; * severe intracranial hypertension; * unstable vital signs; * coagulopathy; * intracranial hemorrhage and occupying; * low back pain; * headache and low back pain before lumbar puncture; * past headache after lumbar puncture; * mental retardation, neuropsychiatric symptoms; * children could not immediately act after the lumbar puncture(such as disturbance of consciousness or suffering from underlying diseases or drainage); * the case with repeated puncture in one operation
correlation of airflow limitation and other respiratory characteristics with radiologic changes of lung structure

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the aim of the study is to assess the correlation between airflow limitation, perception of dyspnea and functional capacity with anatomic changes in pulmonary structure as seen on high resolution ct in copd patients.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of copd * able to perform pulmonary function testing exclusion criteria: * pregnant women
radiographic and clinical comparison of post-reduction splinting constructs in the treatment of acute displaced distal radius fractures

Conditions: Radius Fractures

Summary: subjects with acute, displaced distal radius fractures will be randomized at the time of emergency room evaluation to one of two commonly accepted splinting methods for displaced distal radius fractures: sugar tong splints or volar/dorsal clam shell splints. reduction will be performed in the usual, standard fashion and the selected splint applied. standard radiographic measurements of alignment, including radial height, volar tilt and inclination will be measured on pre- and post- reduction radiographs by a single reviewer- who will be blinded to splint application type. at the first fracture follow-up visit, typically occurring between 5-10 days, as in standard practice, repeat radiographs of the wrist will be taken, and the same reviewer will measure alignment. as a secondary outcome, patients will also complete the disabilities of the arm, shoulder and hand (dash) questionnaire at this visit, to compare patients' ability to perform activities of daily living with their respective splints.


Eligibility criteria:
inclusion criteria: * acute, displaced distal radius fracture * isolated injury exclusion criteria: * polytrauma * non-displaced fracture * prior wrist fracture

Keywords: acute, displaced distal radius fracture
effects of the contraceptive implant in women with sickle cell disease

Conditions: Sickle Cell Disease

Summary: the objective of this study is to measure the acceptability and impact of the progestin implant on frequency of vaso-occlusive crises, quality of life, and hematologic parameters in women with scd.

sickle cell disease (scd) is the most common inherited blood disorder in the united states, affecting 100,000 primarily black people. the disease is characterized by chronic pain and infection, and ultimately reduces life expectancy by 20 years compared to people without scd. given the importance of effective contraception for women with sickle cell disease, as well as previously demonstrated therapeutic benefits of hormonal contraception, the etonogestrel implant may be an optimal method of contraception for women with scd. this study aims to measure the acceptability and impact of the progestin implant on frequency of vaso-occlusive crises, quality of life, and hematologic parameters in women with scd. this is a crossover study. participants will be observed over two phases: 1) a 3-month phase with no hormonal contraceptive intervention and 2) a 6-month phase with the progestin implant. during the phase with no hormonal contraceptive intervention, participants must be willing to be abstinent or use a barrier method, or they must have had a permanent contraception procedure such as a tubal ligation or salpingectomy or be using the copper intrauterine device.

Eligibility criteria:
inclusion criteria: * female aged 18-45 * diagnosis of sickle cell disease (ss or sb0) * report of at least 1 vaso-occlusive pain episode per month on average in the previous 6 months * willing to discontinue any hormonal contraception at the time of enrollment. washout period of 1 month required for all hormonal contraception prior to enrollment in the study. * access to a device with text messaging capability * must be able to read and understand english * willing to comply with study procedures exclusion criteria: * sc disease * use of depo provera in the past 6 months * changes to sickle cell medications in the past 3 months * contraindications to use of nexplanon device as per clinical standards * currently pregnant or pregnant within the last month or seeking to become pregnant * currently breastfeeding
khoury technique versus titanium reinforced ptfe membrane in 3d alveolar bone augmentation

Conditions: Alveolar Bone Loss

Summary: in patients with missed lower posterior teeth and resorbed lower jaw, the study aimed at restoring the jaw's height and width to accommodate placing dental implants. the study was designed as a clinical trial with two arms; control group and study group. in the control group, titanium-reinforced polytetrafluoroethylene (ti ptfe) membrane was used to secure the grafted bone mixture in the recipient site. while in the study group, bone-plate technique (khoury technique) for bone restoration was used to secure the grafted bone mixture as well. the donor bone was the lower jaw (for bone particles and bone-plate harvesting) and bovine bone particles mixed together to form the graft mixture. patients were monitored for six months and assessed by x-rays. the outcome variables were volume and height of gained bone in cubic millimeters and millimeters, respectively.

this study targeted bone augmentation in atrophic posterior mandible. two groups were assigned. the first group included titanium-reinforced polytetrafluoroethylene (ti ptfe) membrane as a rigid modality to achieve guided-bone regeneration (gbr): a mixture of autogenous bone (scrapped from the mandibular external oblique ridge) and bovine xenograft was administered on the atrophic recipient area after decortication by low-speed reducing drills, and covered with the mentioned membrane. the second group utilized rigid bone-plates (a bone block was harvested from the mandibular external oblique ridge, then splitted into two plates; one fixated buccally and the other fixated occlusally by bone screws), and the same bone mixture was prepared and introduced as in the first group. all procedures were operated under local anesthesia in a minor oral surgical setting. follow-up time intervals were the first postoperative day, and the sixth postoperative month. two outcome variables were assessed; gained bone volume and gained bone height.

Eligibility criteria:
inclusion criteria: 1. age above 18 years old. 2. good oral hygiene. 3. missing mandibular posterior teeth. 4. no history of bruxism or para-functional habits. 5. residual alveolar ridge height cannot accommodate dental implant placement. 6. patients prepared to comply with the follow-up and maintenance program. 7. agreement and signing the informed consent. exclusion criteria: 1. systemic diseases that may contraindicate the surgery or affect soft tissue or bone healing. 2. heavy smoking (more than 20 cigarettes/day). 3. intraosseous pathological lesion at the intended grafting site. 4. gingival inflammation at the intended implant site. 5. periodontal diseases affecting teeth adjacent to the edentulous space. 6. inadequate inter-arch space after the indented vertical augmentation.
chidamide + r-gemox regimen as salvage treatment for transplant-ineligible patients with relapsed/refractory dlbcl

Conditions: Lymphoma, Large B-Cell, Diffuse

Summary: the purpose of this multi-center,single arm,phase ⅱ clinical trail is to determine the safety and efficacy of chidamide with r-gemox(rituximab、gemcitabine plus oxaliplatin) regimen in the treatment of transplant-ineligible patients with relapsed/refractory diffuse large b-cell lymphoma.


Eligibility criteria:
inclusion criteria: * biopsy proved cd20+ dlbcl; * relapse or refractory dlbcl# * previously received systemic chemotherapy with anthracycline# * not eligible for autologous hematopoietic stem cell transplantation# * at least one evaluable lesion# * ecog ps 0-1; * 18-75 years; without other malignancy; * proper functioning of the major organs. exclusion criteria: * double-hit lymphoma; * previously received treatment of hdac inhibitor; * plan to receive autologous stem cell transplantation; * involvement of central nervous system; * previously received gemcitabine within the past 6 months; * patients who received treatment for hematologic toxicity caused by previous chemotherapy within 7 days before enrollment;