Kornimate/medical-research-clean huggingface dataset:
autologous transplantation of cultured fibroblast on amniotic membrane in patients with epidermolysis bullosa

Conditions: Epidermolysis Bullosa With Mitten Hands

Summary: epidermolysis bullosa (eb) is a blistering disease that is caused by defective anchoring fibrils and hemidesmosome in basement membrane of the skin layer. eb is inherited either autosomal or recessive and has 3 types. recessive dystrophic epidermolysis bullosa (rdeb) is severe with some morbidity such as mitten hand deformity. the management of these patients is very difficult because no effective treatment has been known yet. the eb patients with mitten hand deformity need surgery to have a biologic dressing for areas of hand which is without the skin. in this study the investigators assess the safety of autologous transplantation of cultured fibroblast on amniotic membrane (am,as coverage) for them.

epidermolysis bullosa patients with mitten hand deformity were included. (based on inclusion \& exclusion criteria) these patients should be offered for surgery to release the adhesions between fingers and mcp. when the consent form was accepted and the lab test was confirmed, a small skin biopsy was removed from retro auricle and fibroblast cells were separated and cultured. these cells were seeded on am and the microbial test was done as evidence to prove the safety. under general anesthesia, when the hands adhesion was removed, the autologous fibroblast cultured on am was transplanted to the both hands (specially the area without skin coverage) and the hands were dressed afterward. the dressing was changed and the wound was checked regularly to detect any complications.

Eligibility criteria:
inclusion criteria: * both genders age: 5-25y no history of other systemic disease no history of other cell therapy method no infection in donor or recipient site hcv ab/hiv ab/ hbs ag tests were negative exclusion criteria: * age less than 5y or more than 25y. history of other systemic disease history of other cell therapy method infection in donor or recipient site positive lab tests for contagious viral diseases pregnancy or lactating history of malignancy

Keywords: epidermolysis bullosa mitten hand deformity autologous cultured fibroblast amniotic membrane
rct on elderly patients undergoing colorectal cancer surgery with enhanced geriatric care

Conditions: Colorectal Cancer

Summary: this study evaluates the effects of enhanced geriatric input on elderly patients undergoing colorectal cancer surgery. half of the participants will received additional pre, peri and post-operative care from the geriatric team, while the other half will receive standard surgical care.

additional geriatric care involves appropriate assessments and interventions by a multidisciplinary team involving geriatricians, physiotherapist, occupational therapist, surgical team, dietician and social worker. it is divided into three stages of care: 1) preoperative assessment, 2) perioperative care and 3) discharge or rehabilitation. in preoperative assessment, a comprehensive geriatric assessment will be carried out which encompasses patients medical and social backgrounds, cognitive status, nutritional assessment and risk factors identification. perioperative care includes a joint care by surgical and geriatric teams aiming to prevent and treat any postoperative complications. discharge and rehabilitation aim to identifies and facilities any potential discharge problem or accelerates patients for rehabilitation to the appropriate locations. standard surgical care will be given to patients who are undergoing colorectal cancer surgery but without the additional input mentioned above.

Eligibility criteria:
inclusion criteria: 1. consecutive colorectal cancer patients (aged 70 and over) undergoing elective colorectal cancer surgery at the prince of wales hospital, shatin, hong kong 2. american society of anaesthesiologists fitness score of i, ii or iii exclusion criteria: 1. colorectal cancer patients aged 69 or under undergoing colorectal surgery 2. patients undergoing emergency colorectal cancer resection 3. patients with benign pathology 4. patients with evidence of locally advanced or metastatic spread of their primary disease 5. patient who are unable to give informed consent

Keywords: elderly enhanced recovery after surgery
research on association between selenium deficiencies and change of thyroid function

Conditions: Selenium Deficiency

Summary: as one of the essential micronutrients, selenium has important biological functions. however, an effective and convenient method for evaluation of selenium nutritional status has not yet been established. previous literature has disclosed effect of selenium deficiency on inactivating glutathion peroxidase and deiodinase, which may cause decreased conversion from thyroxine ( t4) to triiodothyronine (t3). a case-control study is designed to demonstrate the association between selenium deficiency and abnormally elevated t4 or t4/t3, which may provide more clues for establishing effective selenium assesment methods.


Eligibility criteria:
inclusion criteria: * with normal free triiodothyronine( ft3), free thyroxine (ft4) and thyroid-stimulating hormone (tsh). * without thyroid hormone replacement therapy * without medical history of thyroid surgery * without iodine radiotherapy; exclusion criteria: * acute critical illness in the latest 1 year; * weight fluctuation by more than 5% in the latest 3 months; * eating disorders * neuropsychological disorders * allergy to corn or yeast * fail to give informed consents.
ultrasound combined with smi imaging on children with limb lengthening

Conditions: Bone Anomalies

Summary: in the present study, the use of ultrasound allows observation of new bone formation in the distraction gap, also visualize the formation of blood vessels in the distraction gap, including the velocity and resistance of blood vessels, and can also indicate the environment of new bone formation. it's considered that ultrasound detection of new bone and angiogenesis in the process of bone lengthening in children could be a good supplement to x-ray evaluation, and even partially replace the former, reducing the radiation burden of pediatric patients.

limb lengthening is one of most common surgical techniques for correcting limb deformities in pediatric patients. the evaluation of new bone formation in the distraction gap is very important for the prognosis of limb lengthening. after limb lengthening, weekly or biweekly plain x-ray is the most commonly-used method to evaluate new bone formation in the distraction gap. however, ordinary x-ray (film or digital) cannot provide details of regeneration or vascular regeneration like ultrasound examination, and radiation damage caused by x-ray or ct has unpredictable negative effects on minors. ultrasound and x-ray examination were performed every 2 weeks during lengthening in 30 pediatric patients. ultrasound was used to observe the formation of new bone, the number of vertical vessels and the blood flow resistance index, which were compared with the corresponding x-ray findings.new bone states could be divided by us into three stages: stage i (early lengthening): no obvious callus formation was found x-ray and ultrasound; stage ii (lengthening stage): x-ray showed low density callus formation and uneven density, which was divided into three stages by ultrasound: iia, punctate callus could be seen; iib, linear callus was found, but not connected; iic, connected linear callus was found; stage iii (healing stage): the broken ends of the bone were joined, the periosteum was continuous, and the callus had disappeared. x-ray showed healing of the lengthened bone.

Eligibility criteria:
inclusion criteria: * all are children who suffer limb length discrepancy and need limb-lengthening procedure; with no difference in sex, age or ethics. exclusion criteria: * space of braces is smaller than the probes.
heart failure management in azerbaijan

Conditions: Heart Failure

Summary: this study is proposed to determined a national database of the etiologies, clinical and the demographic profile, using diagnostic tests and treatment of outpatients with chronic heart failure in azerbaijan population.

chronic heart failure remains the leading cause of hospitalization for those over the age of 65 and expected to increase over the next 25 years with advancing life span. being a progressive syndrome, chf decreases the quality of life and place an economic burden on health care system. advanced technologies in interventional cardiology, better organization of angiographic laboratories and primary prevention of coronary artery disease as the leading cause of hf, allowed warning its development in cad patients. but the incidence and prevalence of chf continue to increase with age as heart failure with preserved ejection fraction predominates in elderly patients. for the moment more than 23 million people over the world suffer from heart failure. the prevalence of these patients remains very high even in usa - over 5.8 million.however, there is no any database for heart failure patient in azerbaijan.the purpose of this study is to compose a national database of the etiologies, clinical and demographic characteristics, using diagnostic tests and management of outpatients heart failure in azerbaijan population.

Eligibility criteria:
inclusion : * patients \>18 years olds * clinical diagnosis of heart failure * nyha class ii-iv heart failure exclusion : * patients \<18 years old * failure to obtain informed consent * pregnant or lactating previous cardiac transplantation

Keywords: heart failure
adverse events and genomics in schizophrenia

Conditions: Adverse Effect of Other Antipsychotics and Neuroleptics

Summary: the purpose of this study is to find genes that predict whether or not a person will develop side effects to antipsychotic medications, such as weight gain, blood sugar dysregulation, or immune cell abnormalities. we will be collecting blood samples from participants who are taking second-generation antipsychotic medications. these blood samples will be stored over the long-term in a biobank, and will be used for later genetic testing and other cell-based studies.

all data (including blood samples and medical information gathered from participants) will be labelled with each participant's unique coded identifier. participants' identities will be matched with their coded identifier in a single, hard-copy of a master coding list. the maintenance and security of this list is the responsibility of the principal investigator. all processing steps of the blood samples, including details of the blood draw, nucleic acid extraction, sequence library preparation, and sequence analysis will be documented in a microsoft excel worksheet. this worksheet will be encrypted for privacy. anonymized aliquots of blood samples (as well as any derived cell cultures) will be barcoded before long-term storage in a surveillance-monitored, secured freezer at -80 degrees celsius. samples within the freezer will be maintained via a positional numbered grid within the laboratory information management system. this grid will also allow the study team to link each barcoded sample to a participant's coded identifier. mapped genomic sequences and other data collected from participants will be saved in password-protected folders on the ubc server. the coded sequence data will be transferred to the department of genetics and genomic sciences at mount sinai school of medicine (mssm) for further analyses. data transfer will occur by two factor identification. the mssm secure network is clinical laboratory improvement amendments (clia) certified for secure handling of patient sequence data. the transfer of sequence data between ubc and mssm will be performed under a material transfer agreement which requires that 1) all data and analysis be confined within the secure, password-protected database defined by ubc, 2) not distributed to any third party, and 3) both raw and analyzed data be destroyed from the mssm monthly. this study is not required to comply with any u.s. federal regulations, as the group in mssm will not have access to any identifying information about our participants.

Eligibility criteria:
inclusion criteria: * must be taking an antipsychotic medication (no limit on treatment duration) exclusion criteria: * none

Keywords: antipsychotic agents adverse effects genomics transcriptome
the effect of daily living activities mobile application developed for individuals with chronic mental disorder on functionality

Conditions: Chronic Mental Disorders

Summary: the study was conducted to evaluate the functionality of a mobile application programme developed to help individuals with chronic mental disorders plan and implement their daily activities and its impact on activities of daily living. the main questions it aims to answer are: does the activities of daily living mobile application programme improve participants' activities of daily living? does the activities of daily living mobile application programme improve the activities of daily living? does the activities of daily living mobile application programme improve participants' medication adherence?

this study was conducted to evaluate the effect of a mobile application program developed to enable individuals with chronic mental disorders to plan and implement their daily activities on their functionality, daily activities, and medication adherence. the study was designed as an experimental study with a control group, including pre-test, post-test, and follow-up measurements. a total of 64 patients with chronic mental disorders who met the inclusion criteria were included in the study, with 32 in the intervention group and 32 in the control group. data were collected using the introductory information form, the social functioning assessment scale (sfas), the lawton instrumental activities of daily living (iadl) scale, and the morisky medication adherence scale (mmas). participants in the intervention group were administered the activities of daily living-based mobile application programme developed in this study.

Eligibility criteria:
inclusion criteria: - individuals diagnosed with schizophrenia and bipolar disorder according to dsm-v * individuals aged between 18 and 65 * i've been in treatment for the last 3 months * can speak and understand turkish * open to communication and co-operation * those who did not get 0 points from the phone usage step of the lawton iadl (lawton instrumental activities of daily living scale) data collection tool * android phone owner exclusion criteria: * hearing, vision, speech and comprehension problems * individuals who did not attend the two scheduled sessions

Keywords: chronic mental disorders mobile application activities of daily living model functionality psychiatric nursing
environmental influences on early childhood obesity

Conditions: Childhood Obesity

Summary: few treatments have been developed for young children with obesity from diverse backgrounds. the present study will develop and test an intervention designed to improve preschool obesity in latino children. the intervention will focus on improving eating, activity, and sleep behaviors and the home environment for improved weight status.

children from low income families of minority status are at greater risk for development of obesity. there are no known existing treatments for pediatric obesity that focus on improving parental behaviors and the home food and activity environment. the objective of this study will be to address this limitation by developing and testing a novel treatment for low-income minority families. the objective will be attained by testing the following hypothesis: a parent-focused, home-based treatment aimed at improving parental feeding behaviors, child exposure to fruits and vegetables, and the home food and activity environment will result in significantly greater decrease in percent overweight / obesity compared to recommended practice. the hypothesis will be tested by using the approach of a pilot randomized control trial (rct). the rationale for this aim is that success of the planned research will derive a treatment package that will provide the basis for the rct. the planned research is expected to show the level of impact of changing parental feeding behaviors and the home environment on childhood overweight / obesity.

Eligibility criteria:
inclusion criteria: 1. mothers will identify themselves as being latino 2. obese preschool children will be required to have a bmi percentile at or above the 95th percentile, based on sex specific, bmi-for-age population referenced growth charts 3. participating children will be required to have at least one primary caregiver who is english-speaking as their primary language and live within 50 miles of the ucd for the initial treatment development phase (n=3) and at least one family who is spanish speaking (n=1). however, all families participating in the randomized portion can also be exclusively spanish speaking. exclusion criteria: 1. children with medical conditions known to promote obesity will be excluded along with individuals involved with a weight-control program or those taking appetite-affecting medications 2. children who are greater than 100% overweight 3. children will be excluded who have a reported disability, illness, or disorder that would significantly affect diet or activity behaviors 4. children identified by parents with significant food allergies 5. involvement with stage ii, structured weight management for obesity.
the effects of resistance training and protein supplementation in healthy elderly men and women.

Conditions: Muscle Loss in Elderly

Summary: the main objective of this study is to examine the effects of resistance type exercise training combined with nutritional support on body composition and muscle characteristics in healthy elderly men and women. for a comprehensive insight into the potential underlying mechanisms of the intervention effects on whole body-, muscle- and myocellular level, a broad range of tests will be performed before, during, and after the intervention period.


Eligibility criteria:
inclusion criteria: * over 65 years * healthy men and women exclusion criteria: * cardiovascular disease * copd * parkinson * rheumatoid arthritis * musculoskeletal/orthopaedic disorders * cognitive impairment * subjects with metal implants

Keywords: elderly sarcopenia protein drink resistance training
long-term follow-up of immunogenicity of a single dose of japanese encephalitis chimeric virus vaccine (je-cv) in toddlers

Conditions: Encephalitis; Japanese Encephalitis

Summary: this is a long-term follow-up of the persistence of immune response in participants who previously received a single dose of je-cv at age 12 to 18 months in study jec02 (nct00735644) . no vaccination was administered during the present long-term follow-up study. primary objective: * to describe the yearly persistence of humoral immune response to japanese encephalitis after a single dose of je-cv

persistence of immune response will be determined in participants who previously received a single dose of je-cv at age 12 to 18 months in study jec02 (nct00735644). no vaccination will be given in this study.

Eligibility criteria:
inclusion criteria : * provision of informed consent form signed by at least one parent or other legally acceptable representative, and by at least one independent witness if required by local regulations. * participant who was vaccinated with je-cv in jec02 trial and had a pre-vaccination blood sample at baseline in jec02 trial. * participant and parent/legally acceptable representative able to attend all scheduled visits and comply with all trial procedures. exclusion criteria : * receipt of any je vaccine other than je-cv during jec02 trial and during the period up to inclusion in jec05 trial. * planned participation in another clinical trial up to the first year of the follow-up in the present trial.

Keywords: encephalitis japanese encephalitis japanese encephalitis chimeric virus vaccine toddlers
detection of staph colonization in pre-op arthroplasty patients

Conditions: Surgical Site Infection

Summary: this study will evaluate which body site(s) provide the best source of possible staph presence in participants undergoing total joint arthroplasty. if the pre-operative cultures indicate staph presence, an infectious disease specialist will be consulted for standard of medical care consultation and treatment management. participants will be followed for 2 years post-implantation of prosthetic joint to monitor development of prosthetic joint infection.

the presence of staph in/on a patient who will undergo total joint replacement is a risk in that the patient could go on to develop infection at the surgery site after surgery. the purpose of this study is to evaluate if it is beneficial to to administer a questionnaire and obtain cultures from various body sites from patients prior to surgery and also to determine which body site(s) provide the best source of possible staph presence. if the pre operative cultures indicate staph is present, an infectious disease specialist will be consulted for standard of medical care consultation and treatment management. all patients scheduled to have total joint arthroplasty are eligible to participate. the research team will follow the study patients for 2 years after they undergo prosthetic joint implantation to monitor for development of prosthetic joint infection.

Eligibility criteria:
inclusion criteria: * all adult patients undergoing prosthetic joint implantation exclusion criteria: * none

Keywords: staphylococcus aureus prosthetic joint implantation