Kornimate/medical-research-clean huggingface dataset:
online cbt-i for high blood pressure

Conditions: Hypertension; Prehypertension; Insomnia

Summary: the purpose of this study is to compare the effect of 6-weekly, 20 minute sessions of 2 online behavioral sleep interventions (cognitive behavioral therapy or healthy sleep habits) on blood pressure, sleep, depressive symptoms and anxiety in people with insomnia and prehypertension or hypertension.

approximately 30% of us adults have prehypertension (untreated blood pressure ≥120-139/80-89 mmhg) and 29% have hypertension (blood pressure ≥ 140/90 mmhg or antihypertensive medication use). numerous factors contribute to the development of prehypertension and hypertension including age, genetics, obesity, and behavioral factors such as exercise and diet.however, the sleep disorder insomnia is another behavioral factor increasingly implicated with risk of hypertension. insomnia, the most frequent sleep complaint in adults, is characterized by difficulty falling asleep, trouble maintaining sleep or non-restorative sleep coupled with significant daytime distress or functional impairment. insomnia is a pervasive sleep disorder associated with decreased quality of life, reduced work productivity, and increased health care costs; it is increasingly identified as a cardiovascular disease risk factor. lifestyle modifications recommended for pre-hypertension and hypertension do not address sleep. this pilot randomized clinical trial will test the preliminary efficacy of an online cognitive behavioral therapy intervention (n=40) versus an online healthy sleep habits intervention (n=20), to reduce blood pressure in a sample of untreated individuals with insomnia and prehypertension or hypertension. participants will be followed for 12-weeks post-intervention. primary outcome measures are systolic blood pressure. secondary measures include sleep efficiency, insomnia severity, physical and mental function.

Eligibility criteria:
inclusion criteria: * prehypertension or hypertension, insomnia (difficulty getting to sleep, staying asleep and/or early morning awakenings), internet access, current email use, willingness to be randomized to either intervention group, ability to read/write in english. exclusion criteria: * medication known to alter sleep, sleep disorder (other than insomnia), frequent travel over 2-3 time zones, currently receiving behavioral treatment for insomnia, major depression, anxiety disorders, ptsd or bipolar disorder, \>14 alcoholic drinks/week, recreational drug use, prior diagnosis of: epilepsy, dementia/alzheimer's disease, renal failure requiring dialysis, stroke, secondary hypertension, angina, peripheral artery disease, heart failure, myocardial infarction or cardiac surgery within the past 6 months

Keywords: cognitive behavioral therapy for insomnia sleep hygiene
predicting gastric cancer response to chemo with multimodal ai model

Conditions: Gastric Cancer; Chemotherapy Effect

Summary: this study aims to develop a multimodal model combining radiomic and pathomic features to predict pathological complete response (pcr) in advanced gastric cancer patients undergoing neoadjuvant chemotherapy (nac). the researchers intended to collected pre-intervention ct images and pathological slides from patients, extract radiomic and pathomic features, and build a prediction model using machine learning algorithms. the model will be validated using a separate cohort of patients. this research intend to build a radiomic-pathomic model that can outperform models based on either radiomic or pathomic features alone, aiming to improve the prediction of pcr in gastric cancer.


Eligibility criteria:
inclusion criteria: * patients with histologically confirmed adenocarcinoma of the stomach or esophagogastric junction who received nac and radical gastrectomy; * patients who underwent abdominal multidetector computed tomography (ct) inspection, gastroscope, and tumor tissue biopsy before any intervention started; * lesions that are assessable according to the response evaluation criteria in solid tumors version 1.1 exclusion criteria: * patients with indistinguishable tumor lesions on the ct images due to insufficient filling of the stomach during the ct inspection; * patients without indistinguishable tumor cell on the pathological slides due to inadequate sampling; * patients with insufficient data.

Keywords: advanced gastric cancer neoadjuvant chemotherapy multimodal pathological complete response
robot-assisted modified kasai portoenterostomy versus open kasai portoenterostomy for biliary atresia

Conditions: Biliary Atresia; Kasai Operation; Robotic Surgery; Open Surgery

Summary: open kasai portoenterostomy (okpe) is considered the standard treatment procedure for biliary atresia (ba). robotic-assisted kasai portoenterostomy (rakpe) has been utilized to treat ba. however, there were no randomized controlled trials to verify its effectiveness. the objection was to compare the efficacy of da vinci robot-assisted with open kasai portoenterostomy for biliary atresia.

biliary atresia (ba) is one of the most common cholestatic childhood diseases, with an estimated incidence of 1 in 8000-18,000 live births. ba is a progressive cholangiopathy with fibro-obliterative obstruction of the bile duct. the exact pathogenesis and etiology of ba have not been fully elucidated. the hypothesis that is most widely recognized states that injury to the biliary duct is caused by an initial infection and then an autoimmune response is induced by infection, leading to progressive damage to the biliary duct. typical clinical manifestations of ba include persistent jaundice, acholic stools, and pigmented urine in the first months after birth. unfortunately, the presentation time of the clinical features can be delayed in ba, which may lead to misdiagnosis. the average diagnostic age of ba is 60 days in many countries. currently, effective management for ba is the kasai portoenterostomy (kpe), which was originally reported by morio kasai in 1959. open kasai portoenterostomy (okpe) has been introduced to restore bile drainage for patients with ba and become the gold standard. esteves et al. reported laparoscopic kasai portoenterostomy (lkpe) for ba in 2002, but its efficacy remains controversial compared with okpe. several centers have revealed positive results with modified lkpe procedures. nonetheless, lkpe is still a complex and challenging procedure with difficulties in fiber block dissection and anastomosis, resulting in a long learning curve. with merits of articulating wrists, 3d imaging field of vision and filter tremor, robotic surgery has been gradually applied to hepatobiliary disorders in children. theoretically, robotic-assisted kasai portoenterostomy (rakpe) may overcome the difficulties of lkpe in fiber block dissection and anastomosis, thereby becoming a better option for ba. currently, reports of rakpe in infants with ba are limited to small case series, and its effectiveness remains controversial. however, there were no randomized controlled trials to verify its effectiveness. the objection was to compare the efficacy of da vinci robot-assisted with open kasai portoenterostomy for biliary atresia.

Eligibility criteria:
inclusion criteria: * patients diagnosis type ⅲ biliary atresia who underwent open kasai portoenterostomy or robotic-assisted kasai portoenterostomy, aged no more than 6 months. exclusion criteria: * typeⅰbiliary atresia and typeⅱbiliary atresia. biliary atresia combined with severe cardiopulmonary diseases.

Keywords: biliary atresia kasai portoenterostomy robotic kasai outcome rcts
facial emotion recognition in anorexia nervosa

Conditions: Anorexia Nervosa

Summary: altered emotional processing is reported in anorexia nervosa. however, this capability is generally measured through explicit measures, like self-report questionnaires and facial emotion recognition tasks. instead, no previous research has investigated implicit emotional processing in this clinical condition. in the implicit facial emotion recognition task grounded on the implicit "redundant target effect", individuals generally respond faster when two identical targets are presented simultaneously rather than when presented alone; moreover, the competitive presence of a distractor (that is another emotion or a neutral expression) affects the correct recognition of the target. the ability to recognize and detect facial expressions is explored about two main emotions, fear and anger, because of their role in the intra- and interindividual psychological processing.


Eligibility criteria:
inclusion criteria: * right-handed * diagnosis of anorexia nervosa according to the apa criteria exclusion criteria: - concurrent neurological, neurodevelopmental (e.g., autism), motor, somatosensory and/or psychiatric disorders.

Keywords: facial emotion recognition fear anger redundant target effect alexithymia
the role of electroacupuncture with standard therapy on sperm analysis and sod levels in oligozoospermia.

Conditions: Oligozoospermia; Oligoasthenozoospermia; Oligoasthenoteratozoospermia

Summary: the goal of this clinical trial is to compare in oligozoospermia patient. the main questions it aims to answer are: 1. electroacupuncture therapy and standard therapy can affect oligozoospermia. 2. electroacupuncture therapy and standard therapy can affect semen and spermatozoa plasma sod levels. researchers will compare patient with standard therapy with patient with standard therapy with electroacupuncture.

1. male subjects aged more than 25 years and less than 45 years. 2. oligozoospermia according to the 2010 who criteria is mild (10-15 million spermatozoa/ml), moderate (5-10 million spermatozoa/ml) and severe (\<5 million spermatozoa/ml). 3. willing to take part in research and sign informed consent.

Eligibility criteria:
inclusion criteria: * male 25 to 45 years old. * oligozoospermia according to the 2010 who criteria is mild (10-15 million spermatozoa/ml), moderate (5-10 million spermatozoa/ml) and severe (\<5 million spermatozoa/ml). * willing to participate in research and sign informed consent. exclusion criteria: * emergency case patient / bleeding disorders * have a tumor, scar tissue or infected wound in the area where the acupuncture needle will be inserted. * alcoholic * using a pacemaker (heart pacemaker). * azoospermia * varicocele
pet evaluation of brain peripheral benzodiazepine receptors using [11c]pbr28 in hiv-seropositive patients with (mcmd)

Conditions: HIV-Dementia; HIV-Associated Cognitive Motor Complex; AIDS Encephalopathy; AIDS Dementia Complex; AIDS-Related Dementia Complex; HIV Infections; Healthy

Summary: the purpose of this protocol is to measure a receptor in the brain using positron emission tomography (pet) that is involved in inflammation.

the peripheral benzodiazepine receptor (pbr) is distinct from central benzodiazepine receptors associated with gabaa receptors. although pbr was initially identified in peripheral organs such as kidneys, endocrine glands and lungs, later studies identified pbr in the central nervous system. in normal conditions, pbr is expressed in low levels in some neurons and glial cells. pbr can be a clinically useful marker to detect neuroinflammation, because activated microglial cells in inflammatory areas express much greater levels of pbr than in microglial cells in resting conditions. pbr has been imaged with positron emission tomography (pet) using \[11c\]1-(2-chlorophenyl-n-methylpropyl)-3-isoquinoline carboxamide (pk11195). however, this classical ligand provides low levels of specific signal. recently we developed a new ligand, n-acetyl-n-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine \[11c\]pbr28, which showed much greater specific signal than \[11c\]pk11195 in non-human primates. ln the present protocol we plan to perform a kinetic brain imaging study with \[11c\]pbr28 in hlv-seronegative controls, hiv-seropositive, non-impaired patients, and hlv-seropositive patients with minor cognitive motor disorder(mcmd). each subject will recieve a brain-dedicated pet scan with 20 mci\[(11)c\]pbr28.

Eligibility criteria:
* inclusion criteria: inclusion criteria (healthy control subjects) aged 18 50 years with history/physical exam, ecg, and laboratory tests, plus inclusion criteria listed will be included in the protocol. 1. hiv-seropositive based on elisa and western blot (except the hiv-seronegative subjects, who will have elisa screening). 2. capable of providing informed consent. 3. ambulatory at initial visit. 4. if cognitively impaired, the degree of impairment will be mcmd, and not frank hiv-associated dementia. exclusion criteria: 1. current psychiatric illness or severe systemic disease based on history and physical exam 2. current dependence on alcohol or substances other than nicotine. 3. laboratory results from blood or urine tests that show clinically significant abnormalities. 4. previous radiation exposure (x-rays, pet scans etc.) that would exceed research limits. 5. pregnancy and breast feeding. 6. a history of brain disease. 7. cannot lie on your back for long periods since the pictures will be taken for about 2.5 hours during which time you will have to lie still on the scanner bed. 8. more than moderate hypertension. 9. positive result on urine screen for illicit drugs.

Keywords: hiv-dementia brain pet pbr28 mcmd hiv positive hiv dementia aids related dementia minor cognitive motor disorder healthy volunteer hv
safety and toleration of pep005 topical gel when applied to a treatment area of up to 100cm2

Conditions: Actinic Keratosis

Summary: study hypothesis: safety and tolerability will differ when treating multiple contiguous 25 cm2 treatment areas, as compared to individual 25 cm2 treatment areas.


Eligibility criteria:
inclusion criteria: * must be male and at least 18 years of age. * a 100 cm2 contiguous treatment area on each of the right and left extensor (dorsal aspect) forearms, each containing a minimum of 5 ak lesions. exclusion criteria: * cosmetic or therapeutic procedures (e.g., use of liquid nitrogen, surgical excision, curettage, dermabrasion, medium or greater depth chemical peel, laser resurfacing): within 2 weeks and within 2 cm of the selected treatment area(s). * treatment with immunomodulators, or interferon/ interferon inducers or systemic medications that suppress the immune system: within 4 weeks. * treatment with 5-fu, imiquimod, diclofenac, or photodynamic therapy: within 8 weeks and within 2 cm of the selected treatment area(s).

Keywords: peplin pep005 actinic keratosis
atopy patch test in children with food allergy-related gastrointestinal symptoms

Conditions: Food Allergy

Summary: positive reactions in atopy patch test in children with food allergy-related gastrointestinal symptoms

the prevalence of food allergy seems to be increasing, which might explain the increased demand for reliable evaluation of patients with suspected food-related gastrointestinal symptoms. little is known about the diagnostic accuracy of atopy patch tests(apt) in the clinical practice. apt seems to have a better specificity than the ige methods and seems to reflect late-phase clinical reactions.the aims of this study were to evaluate: (i) the prevalence of positive reaction of apts for food allergy-related gastrointestinal diseases. (ii)positive reaction of apt compare with skin prick test. (iii)positive reaction of apt using lyophilized food vs commercially available food extracts. (iv)side effect or adverse events of apt

Eligibility criteria:
inclusion criteria: * patients who had history of suspected food allergy-related gastrointestinal symptoms eg. nausea and vomiting, diarrhea, abdominal pain or hematochezia after ingesting some food. * age 1 month-18 yrs * elimination diet was done at least 7 days before starting the study * written informed consent was obtained from the parents of each child enrolled in the study exclusion criteria: * who have dermographism * who have chronic disease eg. autoimmune disease, immune deficiency, cancer or allergic disease * pregnant women * who have severe eczema * who receive antihistamine, topical steroid and systemic steroid \> 20 mg/day withiin 7 days prior study

Keywords: atopy patch test
obesity and metabolic surgery in patients with type i diabetes

Conditions: Type I Diabetes

Summary: obesity is the indication for bariatric surgery in type i diabetes. interestingly postsurgery the patients improve remarkable in their need for insulin, not only in the daily total insulin dosage but also in the dosage of iu per kg.

the investigators performed a retrospective analysis on 16 patients undergoing weight loss surgery in obesity with concomitant type i diabetes. all patients were evaluated during follow - up to analyze insulin dosage and metabolic changes.

Eligibility criteria:
inclusion criteria: * type i diabetes * bmi \> 40kg/m2 exclusion criteria: * type ii diabetes

Keywords: obesity surgery type i diabetes weight loss insulin dosage postsurgery metabolic changes
determining in vitro properties of epithelial cells from individuals with genetic variants associated with idiopathic pulmonary fibrosis

Conditions: Idiopathic Pulmonary Fibrosis; Healthy

Summary: the investigators are trying to understand the role of specific genes in the function of airway surface cells. the investigators know that there are some common genetic markers that are associated with various lung diseases. however, most people with these genetic markers never develop any evidence of lung disease, so it is not understand how or if these markers play a role in disease. investigators are asking healthy people to provide three (3) tubes of blood as well as a sample of cells from their nose. investigators will use the blood sample to provide genetic information (specifically, presence or absence of alleles known to be associated with pulmonary fibrosis). nose cells from individuals with the genetic markers that investigators are studying will be grown in the the lab to allow investigators to learn more about how the cells respond to various forms of environmental stress, such as exposure to cigarette smoke. the goal of this study is to understand how specific genes affect airway cell function.


Eligibility criteria:
inclusion criteria: 1. age greater than 18 years of age 2. ability to provide informed consent 3. patent bilateral nares exclusion criteria: 1. significant nasal or sinus disease precluding nasal brushing 2. a history of or ongoing epistaxis (nose-bleeding) 3. acute upper respiratory illness 4. ongoing treatment of respiratory or sinus illness with antibiotics 5. pregnancy 6. age less than 18 years 7. infection with human immunodeficiency virus (hiv) or viral hepatitides (hepatitis b, hepatitis c) 8. prior volunteer for the same study 9. known diagnosis of cystic fibrosis or other ciliary disorder (example: primary ciliar dyskinesia) 10. treatment with anticoagulants (examples: warfarin/coumadin, low molecular weight heparins, direct thrombin inhibitors such as dabigatran, anti-platelet agents such as p2y12 inhibitors like clopidogrel and prasugrel, aspirin, ticagrelor, or factor xa inhibitors such as rivaroxaban) 11. known thrombocytopenia (example: immune thrombocytopenic purpura) 12. ongoing chemotherapy 13. known platelet dysfunction or bleeding diathesis/hemophilia

Keywords: epithelial cell function of cells from individuals with various genotypes
the effect on cerebral oxygenation of retrograde autologous priming of the cardiopulmonary bypass circuit in cardiac surgery patients

Conditions: Postoperative Cognitive Dysfunction

Summary: the effect of retrograde autologous priming (rap) on regional cerebral oxygenation (rso2) still remains unclear, because studies are limited in sample size and study design, and because of the absence of prospective studies. the investigators hypothesize that rap limits the degree of hemodilution and thereby limits prolonged intraoperative cerebral desaturation during cardiopulmonary bypass (cpb), compared to the conventional priming method. the primary objective of this study is to determine whether rap limits the degree of hemodilution and limits prolonged intraoperative cerebral desaturation during cardiopulmonary bypass, compared to the conventional priming method. prolonged intraoperative cerebral desaturation will be assessed by rso2 desaturation score50. rso2 desaturation score50 \> 3000 is associated with increased risk of cognitive decline. the investigators hypothesize that rap limits the degree of hemodilution and thereby limits the incidence of rso2 desaturation score50 \> 3000 with a relative difference of 50%. the subjects who are divided in the rap group, the retrograde autologous priming technique will be used, where the patient's own circulating blood partially will be replaced by the priming solution in the cardiopulmonary bypass. in the control group the conventional priming method will be used. the main study parameters is rso2 desaturation score50.


Eligibility criteria:
inclusion criteria: * elective combined cardiac surgical procedures exclusion criteria: * elective single cardiac surgical procedures * off-pump procedure * re-operation * emergency operation * methylene blue administration
post covid-19 functional status in egypt

Conditions: COVID-19; Coronavirus Disease; SARS-CoV-2

Summary: since the outbreak of coronavirus disease - covid-19 pandemic, most attention has focused on mode of transmission, clinical picture of the disease, treatment and prevention. in the coming weeks and months emphasis will gradually involve the post- acute care of covid-19 survivors. it is anticipated that covid-19 may have major impact on physical, cognitive, mental, social health status even in patients with mild disease. moreover, pulmonary, radiologic, laboratory, sleep issues remain to be addressed


Eligibility criteria:
inclusion criteria: * all confirmed cases with covid-19 exclusion criteria: * non covid-19 cases

Keywords: functional score radiologic changes psychologic changes laboratory sleep disturbance
effects of excess energy intake on metabolic risk

Conditions: Insulin Resistance

Summary: the prevalence of obesity has reached epidemic proportions and is associated with the development of insulin resistance and type 2 diabetes (t2dm). a unifying theme has emerged over the past few years suggesting that lipid oversupply to metabolic organs responsible for glucose regulation leads to insulin resistance. fitting with this, we and others have shown that increased lipid accumulation within skeletal muscle and/or liver is associated with impaired glucose uptake. however, the underlying mechanisms that mediate changes in muscle lipid metabolism are not yet known. the overall aim of this project is to examine metabolic effects of experimental weight gain in lean and overweight individuals with and without a genetic predisposition to type 2 diabetes. we hypothesise that lean subjects will increase fatty acid oxidation and upregulate mitochondrial oxidative capacity in muscle following overfeeding to protect against body weight gain and insulin resistance, but overweight subjects with a genetic predisposition to t2dm will have a defect in this ability.


Eligibility criteria:
inclusion criteria: * sedentary (\<60 min formal exercise per week) * aged 20-65 years exclusion criteria: * personal history of diabetes, cardiovascular disease or hypertension * recent weight change (larger than 4kg in the past 3 months) * smoking * regular use of medications, except oral contraceptives * individuals with alcoholism or other substance abuse * pregnancy or lactation, women who are planning to become pregnant or who are not using adequate measures of birth control.