Kornimate/medical-research-clean huggingface dataset:
retrograde and antegrade enema for prevention of lars after lar: a randomized controlled trial

Conditions: Low Anterior Resection Syndrome

Summary: the goal of this clinical trial is to learn if enema works to prevent low anterior resection syndrome (lars) in adults. the main questions it aims to answer are: 1. to describe the level of stoma adaptation before and after the patients received enemas during the stoma period as well as the levels and trends of lars, bowel function, sleep quality, and quality of life after stoma reduction surgery 2. to compare the effects and advantages and disadvantages of antegrade and retrograde enema, and to investigate whether these two types of enema can provide safe and effective preventive measures for the prevention of lars, the improvement of bowel function, and the enhancement of sleep and quality of life in rectal cancer patients after low anterior resection. researchers will compare antegrade enema, retrograde enema, and the standard of care to see if these two types of enema work to prevent lars. participants will: 1. receive either antegrade or retrograde enema or no enema based on the standard of care at 1 month after anterior rectal resection, until the ileostomy reversal. 2. keep a diary of their symptoms.


Eligibility criteria:
inclusion criteria: * based on the nccn guidelines for the pathological diagnosis of rectal cancer, patients are identified as having primary rectal adenocarcinoma. * ≥18 years. * for the first time, anterior rectal dissection combined with prophylactic ileostomy was performed using laparoscopic, robotic, and open techniques. * the patient exhibits normal cognitive and expressive abilities. * informed consent was obtained for voluntary participation in the study. exclusion criteria: * american society of anesthesiologists (asa) class iii or higher. * a combination of other intestinal conditions, including inflammatory bowel disease and crohn's disease. * mental disorders and prolonged use of psychotropic medications. * the presence of contraindications to enema administration.
a trial of skeletal targeted radiotherapy using holmium-166-dotmp in patients with multiple myeloma

Conditions: Multiple Myeloma

Summary: multiple myeloma is a disease that resides primarily in the bone and has shown to be sensitive to radiation. administration of a radiotherapy agent that targets the bone, such as holmium-166-dotmp, in conjunction with melphalan and an autologous stem cell transplant, may improve the patient's chance of responding to treatment. the purpose of this study is to determine the amount of holmium-166-dotmp that localizes in the bone and in normal organs, and to evaluate the safety and efficacy of holmium-166-dotmp in the treatment of patients with multiple myeloma.

the purpose of this study is to estimate the radiation absorbed dose to the bone marrow and kidneys based on whole-body gamma camera image data for comparison with that obtained using mathematical models based on whole body counting from a small gamma detection device called a thyroid probe; to obtain pharmacokinetic data following administration of 166ho-dotmp; and to evaluate safety and efficacy in patients who receive 25 gy targeted therapy of 166ho-dotmp and 200 mg/m2 melphalan followed by autologous peripheral blood stem cell transplant (pbsct).

Eligibility criteria:

Keywords: multiple myeloma transplant skeletal targeted radiotherapy holmium
preoperative survey

Conditions: Cognitive Impairment

Summary: this study will examine preoperative concerns in older adults through the use of a self-administered questionnaire. the development of this questionnaire will involve adapting survey questions from previously validated studies, creating new questions, and generating a comprehensive questionnaire.

the primary objective is to assess the preoperative concerns in older adults. this objective will be assessed by using a self-administered questionnaire. the secondary objective is to examine older adults' attitudes toward preoperative cognitive assessments, functional assessments, and prehabilitation programs. similarly, this objective will be assessed by using a self-administered questionnaire. survey administration will be completed online and in person. recruited participants will receive an email that contains an external link to the online version of the survey that will be administered on research electronic data capture (redcap), an online platform to complete secure surveys. once received, participants will be able to anonymously complete the survey and not have to provide any identification information except for general sociodemographic variables. alternatively, study personnel will administer the questionnaire online/ in person at the preoperative clinic to assess surgical population at mount sinai hospital.

Eligibility criteria:
inclusion criteria: * older adults, who are aged 65 or older and * medical patients in geriatric clinic or surgical inpatients in pre-operative clinics exclusion criteria: • lack english language capability

Keywords: elderly, surgical
strong women study

Conditions: Oxidative Stress; Inflammation

Summary: the investigators investigate the impact of an encapsulated fruit, berry and vegetable juice powder concentrate on oxidative stress, inflammation and blood flow before and post exercise in overweight, middle-aged, women. main hypotheses (h1): * the nutraceutical has an impact on oxidative stress reduction. * the nutraceutical has an impact on inflammation. * the nutraceutical has an impact on blood flow and microcirculation. * walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers. * walking exercise for 30 minutes has an impact on blood flow and microcirculation * the combination of nutraceutical supplementation + walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers, and on blood flow/microcirculation.


Eligibility criteria:
inclusion criteria: * women * bmi \> 27 * praemenopausal * non smokers * eligibility for exercise * 4wk wash out exclusion criteria: * male * all people not matching this age group * bmi \> 40 and \< 27 * peri- or postmenopausal women * smokers * all women taking dietary supplements * all women that fail in ergometric exercise eligibility testing, refering to the standards in sports medicine (e.g.: significant st-decrease or increase, blood pressure \> 240 mmhg, tachycardia, polymorphic extrasystolia, cyanosis, bradyarrhythmia..) * diabetics * osteoporosis or osteopenia

Keywords: oxidative stress inflammation blood flow
reliability of clinical limb-length measurements methods

Conditions: Leg Length Inequality

Summary: there are numerous ways to measure limb length discrepancy in the clinical practice, although their reliability and accuracy are not well known. in our prospective diagnostic study we aimed to test the most popular methods and compare their results to eos 3d reconstructions data.


Eligibility criteria:
inclusion criteria: * age: 18-30 years * bmi: \< 30 * without orthopaedic complaint exclusion criteria: * previous surgery on lower limb or spine * developmental disorder in the patients history

Keywords: leg length inequality leg length discrepancy eos 2d/3d physical examination length measurement
observational data analysis in eurosida (mk-0518-058)

Conditions: HIV-1 Infections

Summary: the main objective of the study is to monitor health outcomes associated with antiretroviral drugs in a population of hiv-infected patients.

time perspective: retrospective and prospective

Eligibility criteria:
inclusion criteria: * adults 16 years old and older with hiv-1 exclusion criteria: * subjects will be excluded if they have no prospective follow up

Keywords: hiv antiretroviral treatment hiv cohort treatment
6-month efficacy and safety of synolis va 80/160 in hip osteoarthritis

Conditions: Osteoarthritis, Hip

Summary: multicenter, independent study of synolis va 80/160 over a period of 6 months


Eligibility criteria:
inclusion criteria: * patient over 18 years of age, * patient with osteoarthritis of the hip. the diagnosis is based on the following criteria: * treated hip pain: oxford score ≥ 21/60, * kellgren-lawrence positive x-ray stage: ii - iii (inclusion radiograph dated no more than 6 months before the inclusion visit), * symptoms related to osteoarthritis of the hip for at least 2 months, * failure of treatments (i.e., inadequate or ineffective response to analgesics and/or nsaids or intolerance to nsaids or low-grade opioids (leaving an oxford score ≥ 21/60), * informed consent form signed by the patient, * the patient has never had a visco supplement injection or corticosteroid injection in the hip to be treated (or more than 6 months old). exclusion criteria: * pregnancy, * participation in another clinical trial, * skin lesion near the injection site, * recent or old infection of the affected joint, * patient with a programmed arthroplasty, * patient with a pathology that makes decision-making impossible, * the patient must not have undergone non-prosthetic hip-conserving surgery such as osteotomy or arthroscopy less than 12 months old.

Keywords: osteoarthritis hip osteoarthritis hyaluronic acid
development of continuous glucose monitoring system cohort for personalized diabetes prevention and management platform

Conditions: PreDiabetes; Glucose Metabolism Disorders; Diabetes Mellitus

Summary: the purpose of this study is to collect a variety of clinical data and blood glucose changes using a continuous glucose monitoring device for high-risk diabetes patients (prediabetes) in order to develop a personalized diabetes prevention and management platform based on artificial intelligence model using mathematical analysis.

after being informed about the study and potential risks, all patients giving written informed consent wear a continuous glucose monitoring device ("ipro2" professional continuous glucose monitoring, medtronicⓡ, california, usa) and smart band ("fitbit inspire hr", fitbitⓡ, california, usa) for 1 week. during this period, all patients are tested oral glucose tolerance test and take a standard diet (calorie calculated) at morning. the patient's data from this study is compared to a predicted values by mathematical analysis model for diabetes prevention.

Eligibility criteria:
inclusion criteria: * above 18 years old. * prediabetes 1. fasting plasma glucose : 100\~125mg/dl, fasting is defined as no caloric intake for at least 8 hours. or 2. 2-hour plasma glucose during 75g oral glucose tolerance test : 140 \~ 199mg/dl or 3. glycated hemoglobin(hba1c) : 5.7\~6.4% (39-47mmol/mol) exclusion criteria: * with a history of newly diagnosed and treated cancer within the last 5 years * with a history of hospitalization for active disease within the last 3 months * with a history of severe cardiovascular disease within the last 3 months * with a history of steroid treatment in the last 3 months * people who have had major surgery planned within the last 3 months or who have had surgery within 3 months * people who are pregnant or have been in the last 3 months after giving birth
histamine pharmacogenetics in children with atopic dermatitis

Conditions: Dermatitis, Atopic

Summary: the primary goal of the study is to investigate the impact of a common genetic polymorphism in a histamine detoxification enzyme that may well have a common role in regulating the expression of atopic dermatitis (ad) and other related atopic diseases in children.

atopic dermatitis (ad) is a common condition in the pediatric population, affecting an estimated 15% of all children greater than 18 months of age in the united states. it is now recognized that ad is a disease of significant heterogeneity with respect to both disease severity and response to conventional pharmacologic therapies. with the recognition of this variability comes the understanding that, as with many other allergic disease, there exist many specific disease phenotypes that ultimately govern response to pharmacologic intervention. the characterization of these unique phenotypes and their associated biologic mediators is therefore of critical therapeutic importance in the development of disease and patient-specific treatment strategies. the long term objective of this research is to explore the effects of genetic, environmental and developmental influences on the primary determinants of histamine action in atopic children and to identify potential histamine "haplotypes" that may be predictive of disease severity, progression and/or response to therapy. the primary hypothesis is the presence of hnmt t314 allele and /or slow acetylation genotype is associated with childhood atopic dermatitis.

Eligibility criteria:
inclusion criteria: * caucasian, hispanic and african american children ages 6 months to 5 years with a diagnosis of atopic dermatitis within the last 12 months will constitute the candidate pool for enrollment into the study group. the diagnosis of atopic dermatitis will be determined by the presence of at least 3 major diagnostic features (i.e., pruritis, rash,relapsing-remitting presentation, family history or atopy) in addition to at least 3 minor features (including but not limited to xerosis, elevated serum ige, ocular involvement, food allergy). healthy caucasian, hispanic and african american children within the same age range will comprise the pool for enrollment into the control group. exclusion criteria: * any child with atopic dermatitis who has a documented history of asthma or bronchospasm or who is currently receiving treatment for either of these conditions will be excluded. any control subject who has asthma or positive family history of allergy or atopic disease in a first-degree relative (biological mother, father or siblings) will also be ineligible for enrollment.

Keywords: atopic dermatitis eczema genetics histamine
usefulness and acceptability of a connected ergocycle for the elderly in a clinical setting

Conditions: End-stage Renal Disease

Summary: hospitalizations are harmful to patients. without a proper intervention, it will lead to a permanent decline in physical function, especially among frail individuals. ultimately, this will worsen quality of life, as well as the cognitive and functional status of affected elderly people, which will arguably reduce functional independence, increase post-discharge institutionalization and death among frail older adults. it is known that patients receiving early physical evaluation and rehabilitation (in the 24 hours following admission) improves post-discharge orientation, decreases delirium and the need of acute care. the rehabilitation often involves ergocycles, but commercially available devices are expensive and often hard to move, to set up in hospital bed and lack connectivity. in this context, a connected ergocycle prototype which has a number of desired characteristics, including low production cost, relatively light and easy to move and with internet connectivity. the goal of this study is thereby to assess the usefulness and acceptability of the prototype with health professionals involved in physical rehabilitation and patients receiving said rehabilitation.


Eligibility criteria:
inclusion criteria : * \> 55 years old * receiving treatments for terminal renal insufficiency at least 3 times a week, for at least 3 months (hemodialysis; hd) or under mechanical ventilation for less than 72 hours, and that should last for at least 24 more hours (intensive unit care; icu) * physically independent outside hd or before admission (icu) (≥ 70 on the barthel index) * with medical clearance (hd : nephrologist; icu : intensivist) exclusion criteria: * unable to walk without assistance (before icu admission) * diagnosed neurocognitive decline * recent hemiarthroplasty for a hip fracture that causes a limitation in the flexion of the hip during pedaling * already involved in another study exclusion criteria specific for icu patients : * neuromuscular disorder affecting the weaning from mechanical ventilator support * pathologic fracture or unstable cervical spine fracture * hospitalized for more than 7 days * covid-19 positive * reported as moribund by the intensivist
audio recording for improved surgical outcome (ariso)

Conditions: Osteoarthritis

Summary: use of audio recordings (with suggestions and imagery for a better surgical outcome) studied in orthopedic patients.

pt undergoing orthopedic surgery are randomized into 3 groups. these interventionals will be listening to cd recording just prior to and during orthopedic surgery. the 2nd group will be listening to a recording before and during surgery without any positive suggestions. the 3rd group will be receiving usual care. prior to hospital discharge patients will fill out a questionaire assessing their perception of their surgery and hospital stay. pt. charts will be reviewed for use of pain, sleep, anesthesia and nausea medication and for the number of units of blood transfused. pt. outcomes will be asssessed with this data.

Eligibility criteria:
inclusion criteria: * patients scheduled for total hip replacement under reginal anethesia at mayo clinic in jacksonville, fl. * willingness to sign consent. * age 18 or greater.

Keywords: hip surgery perioperative suggestions/imagery
seifem surveillance of antifungal combination therapy in hematologic italian centers

Conditions: Fungal Infection

Summary: this trial is an observational study about combination antifungal therapy in hematologic patients with proven and probable invasive fungal infections (ifi).


Eligibility criteria:
inclusion criteria: * haematologic patients with proven or probable ifi * therapy with a combination of antifungal drugs exclusion criteria: * haematologic patients with possible ifi

Keywords: antifungal therapies
improving fatigue: a pilot study of acupuncture and patient education for breast cancer survivors

Conditions: Fatigue

Summary: based on the investigators clinical experience in patients with chronic disease (hui, hui, and johnston, 2006; hays et al 2005), a review of the literature (johnston, xiao and hui 2007), and inspired by vickers and colleagues (pmid: 15117996), the investigators carry out a pilot study that investigates if acupuncture combined with patient education will relieve fatigue in patients who have completed primary treatment for breast cancer.

patients will be randomly assigned to one of the two groups. our hypothesis is that patients in the acupuncture/education group will experience greater relief of fatigue than those in the standard care group.

Eligibility criteria:
inclusion criteria: 1. patient is between 18 and 65 years of age 2. patient has a rounded brief fatigue inventory score of 4 or greater 3. patient is in a stable clinical condition exclusion criteria: 1. severe anemia (hemoglobin level less than 9 g/dl, hematocrit level less than 30, decline in hemoglobin of 2 g/dl in the previous month, or active treatment for anemia) 2. karnofsky performance status below 70 3. acupuncture treatment in the previous 6 months 4. fatigue before cancer diagnosis 5. patient is mentally incapacitated or unfit to provide informed consent or participate in an interview 6. patient has the potential for serious bleeding due to inherited diseases such as hemophilia 7. patient is taking medications that are either fatigue-inducing or have sedating properties 8. patient is unavailable by telephone

Keywords: cancer acupuncture
ultrasound assessment of gastric contents in fasted elderly patients with hip fracture

Conditions: Hip Fractures

Summary: evaluation of gastric contents in fasted elderly patients with hip fracture. the gastric contents will be examined by using ultrasonography in fasted elderly patients scheduled for hip fracture surgery. the primary outcome is the number of patients with stomach contents, and the secondary outcome is the component of residual gastric contents.

in the patients who has femur fracture, they are immobilized because of the pain. this condition makes the gastric movement slow, and the pain also contributes to delayed digestion. in the present study, the gastric content is assessed by using ultrasonography in fasted elderly patients for hip fracture surgery. ultrasound assessment is performed in the supine position. all patients scheduled elective surgery for hip fracture over 65 years old are objects. the primary outcome is the number of patients with not empty stomach and full stomach, and the secondary outcome is the component of residual gastric contents.

Eligibility criteria:
inclusion criteria: * who has hip fracture and agrees with the purpose of the study exclusion criteria: * gastrointestinal pathology * history of any type of gastrectomy * gastrointestinal anomaly

Keywords: gastroparesis
neurobiology of alcohol and nicotine co-addiction

Conditions: Alcohol Use Disorder; Nicotine Use Disorder

Summary: this proposal addresses the critical absence of information about the neurobiology of recovery from alcohol use disorder (aud) in alcohol and nicotine users.

this proposal addresses the critical absence of information about the neurobiology of recovery from alcohol use disorder (aud) in alcohol and nicotine users. aud and nicotine use disorder (nud) are the most commonly abused (non-prescription) substances in the u.s. co-addiction is particularly high in military veterans. although nationwide estimates peg the rate of aud/nud co-addiction at 80%, the substance abuse treatment program (satp) at the veterans affairs portland health care system (vaporhcs) finds that 90% of veterans treated for aud also meet criteria for nud. the investigators hypothesize that a support vector machine learning algorithm will be able to use the measures to classify subjects as aud, nud both or neither and that the algorithm will predict outcome (sobriety or relapse) at three months.

Eligibility criteria:
inclusion criteria: * none exclusion criteria: * none
effect of kinesiotaping on postpartum pelvic girdle pain

Conditions: Pelvic Girdle Pain

Summary: the purpose of this study is to investigate the effect of kinesiotaping on pelvic girdle pain in postpartum women.

pregnancy-related pain in the sij, lumbosacral region, pubic symphysis, or in any combination of these joints has been coined as pelvic girdle pain (pgp) and has been estimated to affect almost half of all pregnant women. women with pgp have an increased risk of prenatal anxiety, depressive symptoms and postpartum depression compared with healthy pregnant women. kinesio taping is rehabilitative technique used to facilitate the body's natural healing process while providing support and stability to muscles and joints, without restricting their range of motion. enhanced rehabilitation is thought to be the effect of stimulated reactivation, proprioceptive training, reduced pain, stimulation of correct movement patterns, and reduction of muscle imbalance. kinesio taping (kt) method has been used to decrease and prevent pain in women suffering from pregnancy related low back pain because of increased muscle relaxation while taping is applied. however, there is lack of knowledge regarding the effect of kinesiotaping on pgp in postpartum women. therefore, this study will be conducted to provide physiotherapists with a scientific updated knowledge, concerning the effect of kinesiotaping on pain, level of disability and lumbar flexion and extension rom in pelvic girdle pain in postpartum women, aiming to improve adls of postpartum women. this study may expand the role of physiotherapy in women's health

Eligibility criteria:
inclusion criteria: * all post-partum women \< 4 months postnatal having pelvic girdle pain. * they will be diagnosed using faber test, and active straight leg raising test. * their ages will range from 25 to 35 years. * their body mass index (bmi) less than 30 kg/ m². exclusion criteria: * pregnant women or planning for pregnancy. * cardiovascular diseases. * previous spinal surgery. * history of skeletal deformity. * participation at any other exercise training program during this study