Kornimate/medical-research-clean huggingface dataset:
identifying methylation biomarkers for monitoring bladder tumors

Conditions: Bladder Cancer

Summary: to investigate the methylation status of 4-6 genes in urine and matching bladder tissue biopsies, in order to find methylation markers for use in a noninvasive test in monitoring patients with bladder tumors.


Eligibility criteria:
inclusion criteria: * patients with bladder tumors and patients with benign urinary tract conditions with no clinical suspicion of bladder cancer. exclusion criteria: * patients with competing urinary and systemic diseases, pregnant and patients under 18 years of age.
endeavour: phase 3 multicenter study of revusiran (aln-ttrsc) in patients with transthyretin (ttr) mediated familial amyloidotic cardiomyopathy (fac)

Conditions: Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC); Amyloidosis, Hereditary; Amyloid Neuropathies, Familial; Amyloid Neuropathies; Amyloidosis, Hereditary, Transthyretin-Related; Familial Transthyretin Cardiac Amyloidosis

Summary: the purpose of this study was to evaluate the safety and efficacy of revusiran (aln-ttrsc) in patients with transthyretin (ttr) mediated familial amyloidotic cardiomyopathy. dosing has been discontinued; patients are being followed-up for safety.


Eligibility criteria:
inclusion criteria: * documented ttr mutation * amyloid deposits in cardiac or non-cardiac tissue * medical history of heart failure * evidence of cardiac involvement by echocardiogram exclusion criteria: * has known primary amyloidosis (al), leptomeningeal amyloidosis, non-fac hereditary cardiomyopathy, hypertensive cardiomyopathy, or cardiomyopathy due to valvular heart disease * has known peripheral vascular disease affecting ambulation * has a polyneuropathy disability score \>2 * has a new york heart association (nyha) classification of iv

Keywords: cardiomyopathy heart failure fac amyloid transthyretin ttr rnai therapeutic
correlation of urinary kallikrein with cytokines, proteinuria and renal function in chronic renal disease patients

Conditions: Chronic Kidney Disease

Summary: urinary kallikrein excretion is known to increase in patients with nephrotic syndrome and sick cell disease, but decrease in patients with chronic kidney disease or uremia. some of authors consider urinary kallikrein is a marker of nephropathy. to evaluate the possible role of kallikrein kinin system in chronic kidney disease, we conduct a retrospective longitudinal observation study. patients who participating in the "efficacy of pentoxifylline on chronic kidney disease" study are included in the study. the morning spot urinary kallikrein and cytokines are measured at the time point of 0 and 12 month in addition to clinical parameters. the correlation of urinary kallikrein and cytokine concentration will be evaluated. using multiple regression model, the relationship of urinary kallikrein excretion with degree of proteinuria, creatinine clearance and other clinical parameter will also be evaluated.


Eligibility criteria:
inclusion criteria: * during june 2004 and june 2005 who participate the clinical study "efficacy of pentoxifylline on chronic kidney disease" (clinicaltrials.gov identifier: nct00155246)and sign the informed consent. * chronic kidney disease history \> 3 months, serum creatinine: 1.1\~6.0 mg/dl in female. 1.3\~6.2 mg/dl in male. * initial random urine protein (mg/dl) /creatinine (mg/dl) ratio \> 0.5 exclusion criteria: * history of allergy to pentoxifylline; * females are nursing or pregnant; * obstructive uropathy; * unable to stop chronic immunosuppressive therapy, nsaid; * congestive heart failure (new york heart association functional class iii or iv); * unstable angina, myocardial infarction, coronary artery bypass graft surgery, percutaneous coronary intervention, within the past 6 months prior to signing the informed consent form; * cerebral hemorrhage within the past 6 months prior to signing the informed consent form; * retinal hemorrhage within the past 6 months prior to signing the informed consent form; * known or suspected secondary hypertension (e.g., primary aldosteronism, renovascular hypertension, pheochromocytoma); * severe uncontrolled hypertension with sbp \> 220 mmhg and/or dbp \> 115 mmhg; * hepatic dysfunction as defined by the following laboratory parameters: alt or ast \> 2 times the upper limit of the normal range; * biliary obstructive disorders (e.g. cholestasis); * active malignancy

Keywords: kallikrein cytokines proteinuria renal function chronic kidney disease
retrograde recanalization of infrainguinal arterial occlusive disease.

Conditions: Critical Limb Ischemia

Summary: the spectrum of lower extremity peripheral arterial disease (pad) ranges from exhibiting no symptoms to limb threatening gangrene. the number of patients living with it is rising steadily owing to increased life expectancy, obesity, diabetes, and tobacco consumption. critical limb ischemia (cli) is the terminal and the most serious stage of pad in which blood flow to the lower extremity does not meet metabolic demands of the tissues at rest. the diagnosis is mainly clinical and patients are presented with rest pain, minimal tissue loss or frank gangrene. revascularization strategies include endovascular procedures and surgical bypass.endovascular therapy has evolved as an attractive, minimally invasive method of revascularization especially in the more frequently encountered patients with medical and anatomical contraindications to surgical revascularization. antegrade approach is the standard approach in infrainguinal arterial occlusive disease,however, failure occurs in about 20% of infrainguinal attempts.retrograde approach is used as a backup technique in failed cases.


Eligibility criteria:
inclusion criteria: patients with; 1. cli consistent with rutherford categories (4-5). 2. infrainguinal arterial occlusive disease with a patent distal part of at least one tibial vessel runoff to the foot. exclusion criteria: patients with the following conditions will be excluded: 1. non-salvageable limbs. 2. life threatening infections requiring major amputation. 3. ulcers at the area of intended puncture.
management of peri-implantitis: non-surgical treatment of peri-implantitis.

Conditions: Peri-Implantitis

Summary: the goal of this clinical trial is to compare non-surgical treatment by mechanical debridement with air-polishing in peri-implantitis. the main question it aims to answer is: • does non-surgical treatment of peri-implantitis with an air-polishing devise (perioflow® ems, nyon switzerlad) provide a better treatment result than conventional cleaning with mechanical instruments? participants will receive non-surgical treatment of peri-implantitis either with mechanical debridement and with an air-polishing devise. researchers will compare pocket depth and bleeding/suppuration on probing in implants treated with the two methods to see if either of them is more efficient in treatment of peri-implantitis.


Eligibility criteria:
inclusion criteria: * referred to tknn (tannhelsetjenestens kompetansesenter for nord-norge) for treatment of peri-implantitis * participants should have at least one implants with peri-implantitis according to the diagnostic criteria from the 2017 chicago consensus meeting. exclusion criteria: * cemented prosthetic reconstructions, individuals smoking more than 10 cigarettes per day, individuals with diabetes and poor control of blood glucose levels, antibiotic treatment during the past threee months, and implants that are preferably to be extracted due to prognosis or function, are excluded.

Keywords: peri-implantitis non-surgical treatment air-polishing mechanical debridement bleeding on probing periodontal pocket depth
transbucal dexmedetomidine for prevention of sevoflurane emergence agitation in pre-school children

Conditions: Agitation

Summary: the aim of this study is to evaluate the efficacy of transbucal dexmedetomidine given in preschool children undergoing tonsillectomy operations in the prevention sevoflurane agitation.

agitation during the emergence from general anesthesia is a great post-operative problem that often injures the patients themselves and requires the medical staff to restrain and calm them. the predisposing factors for emergence agitation include anesthesia, operation, and patient. sevoflurane anesthesia results in higher incidence of emergence agitation than halothane, because of the rapid emergence, and its effects on central nervous system inducing convulsion and post-operative behavioral changes. the otorhinolaryngologic and ophthalmologic surgeries, post-operative pain, young age, pre-operative anxiety, no past surgical history, and adjustment disorder of patients are risk factors. dexmedetomidine (dex), a selective α (2)-adrenoreceptor agonist. intravenous dex used after induction of anesthesia reduced sevoflurane-associated ea and postoperative pain in pediatric ambulatory surgery. the investigators designed this study to prove the efficacy of oral dexmedetomidine a selective α (2)-adrenoreceptor agonist, on emergence agitation (ea), recovery profiles, and parents' satisfaction after sevoflurane anesthesia in tonsillectomy.

Eligibility criteria:
inclusion criteria: * asa physical status i-ii patients * aged 2-6 years * patient scheduled for elective tonsillectomy due to recurrent * chronic tonsillitis exclusion criteria: * patients with known hypersensitivity to medication drugs * coagulation disorders * thrombocytopenia * significant cardiac * renal * pulmonary * hepatic disease

Keywords: sevoflurane emergence agitation
acute effect of foot reflexology massage on heart rate variability and arterial pulse waveform

Conditions: Massage; Anaerobic Exercise; Aerobic Exercise

Summary: foot reflexology treatment provides acute and chronic effects on cardiovascular and hemodynamic functions. however, no information is available to us in regarding the treatment effect of foot reflexology after exercise. this study investigated the acute effect of foot reflexology treatment on heart rate variability after anaerobic-based and aerobic-based intermittent exercises.

the sympathetic activation and sympathy-vagal balance after repeat sprint performance can be immediately modulated by foot reflexology massage. the acute benefits of foot reflexology intervention on cardiac sympathovagal balance can be considered as exercise recovery strategies in sports.

Eligibility criteria:
inclusion criteria: * undertake football/futsal training at least 3 times a week * age between 18 and 30 years old exclusion criteria: * history of severe neuromuscular injury * current lower extremity injury * current neurological diseases

Keywords: heart rate variability arterial pulse waveform
a postmarket surveillance study of the paradigm spine dynamic stabilization system (dss)

Conditions: Spondylolisthesis; Neurologic Deficits; Kyphosis; Pseudarthrosis

Summary: the purpose of the post-market surveillance study is to evaluate safety.

paradigm spine dynamic stabilization system (dss) study is a prospective, multi-center, literature controlled study.

Eligibility criteria:
inclusion criteria: * patient is skeletally mature (21-85 years old). * patient has degenerative spondylolisthesis (grade 1-3) with objective evidence of neurologic impairment, kyphosis, and/or failed previous fusion (pseudarthrosis) at index level. * capable and willing to comply with the requirements unique to the study, adhere to the post-operative treatment and management program, and return for required follow-up examinations. * surgeon has determined that dss™ system is an appropriate treatment for the patient without regard to the study. exclusion criteria: * the need for interbody cages, allograft, or any other assistance during surgery. device is only to be used with autograft per fda approved indications. * any medical, mental or surgical condition precluding the potential benefit of spinal surgery or surgery in general. * acute or chronic systemic, spinal or localized infections. * active, severe systemic and metabolic diseases. * obesity defined as body mass index \> 35. * subject is pregnant or interested in becoming pregnant in the next 36 months. * dependency on pharmaceutical drugs, drug abuse, or alcoholism. * lack of patient cooperation. * foreign body sensitivity to the implant material. * degenerative scoliosis greater than 25 degrees. * grade 4 degenerative spondylolisthesis (\>75% slip). * significant osteopenia a screening questionnaire for osteopenia, score (simple calculated osteoporosis risk estimation), will be used to screen patients who require a dexa bone mineral density measurement. if dexa is required\*, exclusion will be defined as a dexa bone density measured t score of ≤ -1.0 (the world health organization definition of osteopenia). * soft tissue deficit not allowing wound closure. * congenital abnormalities, tumors or other conditions that would prevent secure component fixation that has the potential to decrease the useful life of the device. * inadequate pedicles or vertebral body geometry of the thoracic, lumbar and sacral vertebrae. * bony lumbar spinal stenosis not related to the primary degenerative spondylolisthesis indication. * pars defect. * clinically compromised vertebral bodies at affected level due to current or past trauma. * prisoner or ward of the state. * currently in litigation regarding a spinal condition. * known allergy to titanium, titanium alloys, cocrmo, polyethylene or mr contrast agents. * is currently involved in a study of another investigational product for similar purpose.

Keywords: spondylolisthesis neurologic impairment kyphosis pseudarthrosis
behavioral couples therapy for female drug-abusing patients

Conditions: Drug Abuse

Summary: in treating drug addiction, many studies of male patients show behavioral couples therapy (bct) helps the whole family (the drug abuser, the relationship partner, and their children) and is more effective than typical individual and group counseling. only one study of bct has been done with female drug-abusing patients, and results were promising but not definitive. the proposed study will test with married or cohabiting female drug-abusing patients whether bct will produce more positive outcomes for the women, their male partners, and their children than standard individual counseling for the patient alone.


Eligibility criteria:
inclusion criteria: * female patients with primary drug abuse diagnosis \& their relationship partners * patient married or cohabiting with relationship partner * partner without current alcohol or drug problem exclusion criteria: * both patient and partner without severe mental health disorders

Keywords: drug abuse female patients
diabetes mellitus with pregnancy in benisuef localities

Conditions: Pregnancy in Diabetics

Summary: the aim of this work is to demonstrate the variation of diabetes mellitus either preexisting or gestational diabetes mellitus among pregnant ladies in our localities, detect maternal \& fetal complications and to predict the risk factors for poor maternal, fetal \& neonatal outcomes


Eligibility criteria:
inclusion criteria: * all pregnant ladies with diabetes mellitus either type 1 or type 2 * all pregnant ladies with glucose intolerance which is first diagnosed during current pregnancy exclusion criteria: * ladies age less than 18 year or above 45
evaluation of new different herbal mouthwashes against caries forming bacteria, rct

Conditions: Dental Caries in Children

Summary: the goal of this randomized controlled trial is to compare three different types of mouthwash, moringa, star anis, and indian costus 90 children participated in this study divided into 3 groups according to the type of mouthwash used and then subdivided in each group into 3 subgroups according to the concentration of the mouthwash 5,10,15%. the children were asked to rinse with the mouthwash 3 times per day for 1 week. bacterial count for streptococcus mutans was measured before and after the use of mouthwash to see the most effective concentration.

the powdered of moringa, star anis, and indian costus leaves (250 g) were extracted using 90% ethanol then filtered using whatman filter paper no.1 and dried under reduced pressure using rota vapor. the crude ethanolic extract was (200 mg). ninety children will be randomly distributed into three groups (1,2,3) (30 children each). each group was divided into further 3 groups (10 children each) according to the concentration of each herbal mouthwash (5,10,15%). each participant will be given a new bottle of a specific effective amount of herbal extract to be used as a mouthwash. children will be instructed to rinse with 5ml of mouthwash. all groups were instructed to rinse three times a day with specific mouthwash for each group for about one minute and participants will be advised to use the mouthwash for seven days. collection of saliva samples prior to the start of the experiment, samples of unstimulated saliva were taken when the child spit a suitable amount of unstimulated saliva in a sterile container in the morning before breakfast. initial salivary samples were collected to establish base levels (s1) using selective culture media, the salivary samples (s2) were collected after one week of using the mouthwash when the child spit a suitable amount of unstimulated saliva in a sterile container in the morning before breakfast.

Eligibility criteria:
inclusion criteria: * - children with no systemic disease, no history of recent antibiotic administration (last 2 weeks), antimicrobial mouth-rinse (last 12 hours), topical fluoride treatment within 4 weeks prior to baseline, children with no untreated active carious lesion, no orthodontic appliance or with low caries index (dmf\& def \< 4) exclusion criteria: * children using antibiotics, medications or mouthwashes at the time of the study, children with oral or systemic disease, children undergoing any dental treatment

Keywords: moringa star anis indian costus mouth wash streptococus mutans
comparison of phenylephrine and norepinephrine for spinal-induced hypotension

Conditions: Spinal Induced-hypotension

Summary: hypotension after spinal anaesthesia for cesarean deliveries is frequently encountered. phenylephrine an α-agonist is commonly used for the prevention and treatment of spinal-induced hypotension. phenylephrine causes baroreceptor-mediated bradycardia leading to subsequent reduction in cardiac output. preservation of heart rate and cardiac output is important in high-risk conditions such as placental insufficiency, fetal distress and maternal cardiac disease. recently, norepinephrine has been found as effective as phenylephrine in treatment of spinal induced hypotension. when norepinephrine is used as a bolus, it is effective at maintaining blood pressure while also conferring a greater heart rate and cardiac output compared to phenylephrine.


Eligibility criteria:
inclusion criteria: elective cesarean delivery under spinal anaesthesia asa ps ii age ≥18 years singleton pregnancy beyond 37 weeks' gestation weight between 50 and 100 kg height between 150 and 180 cm exclusion criteria: patient refusal to participate allergy or hypersensitivity to norepinephrine or phenylephrine preexisting or pregnancy-induced hypertension cardiovascular or cerebrovascular disease fetal abnormalities use of monoamine oxidase inhibitors or tricyclic antidepressants
performance of woundchek bacterial status

Conditions: Wound Heal

Summary: the purpose of this clinical study is to evaluate the performance of woundchek™ bacterial status (wcbs) when the test result is used to inform treatment decisions.

the clinician treating the wound will be allowed to use the test result in treatment decisions. the pretest treatment plan will be documented on the case report form (crf) prior to performing the wcbs test. after receiving the test result the clinician will document the post-test treatment plan. the healing outcome at 12 weeks following the test will be recorded on the crf. the study will evaluate the healing outcomes compared to when test results are not used to assist in treatment decisions with study success defined as a higher healing rate and/or mean wound size reduction for wcbs positive wounds than obtained in the study prot-2023-001. also, the healing rate of wounds with a negative test result will be compared to the pretest rate to ensure that clinicians do not neglect and under treat this cohort with success criteria being that the wcbs negative wound healing rate is not worse than the pre-test healing rate. additionally, the study will establish whether there are any device related serious adverse events (saes) or unanticipated adverse device effects (uades).

Eligibility criteria:
inclusion criteria: 1. subject has presented to the participating study site with a vlu, dfu and / or a pu that is suspected not to be infected, as determined by the investigator and/ or study staff - defined as one that does not show more than two of the nerds signs of infection. 2. subject is 18 years of age or older. 3. the wound is between 21 days and 6 months of age or more than 6 months of age if less than 1cm2 in area. 4. subject agrees to complete all aspects of the study and provides written informed consent per irb requirements. exclusion criteria: 1. subject does not meet inclusion criteria. 2. target wound contains a malignancy. 3. subject has hypersensitivity of the wound or painful wound surface which prevents touching/swabbing of the wound surface. 4. subject is confirmed to be positive for hiv or hepatitis . 5. subject is unable or unwilling to provide informed consent. 6. a designated wound area may only be enrolled once in the study. for example, if an enrolled wound heals to complete closure and then re-opens, it cannot be re-enrolled in this study.
evaluation of a virtual reality tool for identifying the cognitive functions of the right hemisphere in patients with glioma -tango

Conditions: Brain Tumor; Virtual Reality

Summary: evaluate the diagnostic performance of a virtual reality application to detect the presence of cognitive impairment of the non-dominant hemisphere in patients with glioma


Eligibility criteria:
inclusion criteria: * indication for glioma surgery * karnofsky \> 70 exclusion criteria: -
impact of lactate-containing vaginal lubricant on sexual dysfunction in young breast cancer survivors

Conditions: Sexual Dysfunction; Breast Cancer Survivors

Summary: the purpose of this study is to determine whether lactate-containing vaginal lubricant is effective in the treatment of young breast cancer survivors with sexual dysfunction.

study scheme * study arm: apply lactate-containing lubricants at the time of sexual intercourse and before sleep at least 3 times per a week for 8 weeks * control arm: placebo apply outcome measures * female sexual function index (fsfi-20): at 0 wk and at 8 wk * vaginal maturation index: at 0 wk and 8 wk * vaginal ph: at 0 wk and 8 wk

Eligibility criteria:
inclusion criteria: * breast cancer survivors over 20 years-old * premenopausal at the time of diagnosis * treated with operation and chemotherapy * newly developed dyspareunia after cancer treatment exclusion criteria: * recent (\< 2 months) start or cessation of hormonal treatment (tamoxifen etc.) * depression or other psychological problems * active vaginal infection * evidence of cancer recurrence * previously use of lactate-containing lubricants * other chronic diseases which severely disturb the sexual life

Keywords: dyspareunia breast cancer sexual dysfunction vaginal lubricant