Kornimate/medical-research-clean huggingface dataset:
type 1 diabetes, endothelin, and skeletal muscle mitochondrial dysfunction: the role of sirtuin-1

Conditions: Type 1 Diabetes

Summary: the proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-b receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.

preliminary data from the investigators' laboratory demonstrate a negative relationship between hemoglobin a1c (hba1c) and etbr function, supporting etbr may be dysfunctional in the presence of t1d. using near infrared spectroscopy (nirs) to non-invasively assess muscle function, the investigators have also observed reduced skeletal muscle mitochondrial function in people with t1d compared to healthy controls. in addition, reduced circulating sirt1 is associated with both etbr and skeletal muscle mitochondrial dysfunction in the general population. for the current application, the investigators propose to utilize intradermal microdialysis and nirs as unique, novel, and minimally invasive methods to investigate etbr and skeletal muscle mitochondrial function, respectively, in people with t1d. accordingly, the central hypothesis is that increasing circulating sirt1 with oral supplementation of resveratrol will improve both etbr function and mitochondrial skeletal muscle function, reducing overall cvd risk (figure 1). the investigators will test this hypothesis with the following specific aims: aim 1: to test the hypothesis that an increase in sirt1 will improve etbr function in people with t1d. the investigators will evaluate etbr function and circulating sirt1 at baseline and after a 12-week treatment of resveratrol or placebo. based on preliminary data, the investigators predict that people with t1d will have etbr dysfunction compared to controls. in addition, the investigators predict that increasing sirt1 following resveratrol treatment will improve etbr function, whereas no change will occur with placebo. aim 2: to test the hypothesis that an increase in sirt1 will improve skeletal muscle mitochondrial function and lower hba1c in people with t1d. a non-invasive assessment of skeletal muscle function will be performed on people with t1d before and after 12-weeks of treatment with resveratrol or placebo. compared to controls, the investigators predict that people with t1d will have skeletal muscle dysfunction. following 12 weeks of resveratrol, the investigators predict that the increase in circulating sirt1 will improve skeletal muscle function. additionally, the investigators predict the improved skeletal muscle function will contribute to a subsequent decrease in hba1c in people with t1d.

Eligibility criteria:
inclusion criteria: * men and premenopausal women * all races * clinical diagnosis of insulin-dependent type 1 diabetes (patients only) exclusion criteria: * clinical diagnosis of hepatic, cardiovascular, or renal disease * uncontrolled diabetes (hba1c \>12%) * diabetic complications (i.e. neuropathy) * uncontrolled hypertension (\>140/90 mm hg on therapy) * pregnancy * use of vasoactive medications

Keywords: diabetes heart disease muscle function blood vessels
promoting resilience to food commercials decreases susceptibility to unhealthy food decision-making

Conditions: Obesity, Adolescent

Summary: the purpose of this study is to evaluate how food commercials influence food choices in children and their parents.

the proposed research will investigate food decision-making in youth. childhood obesity is a risk factor for health issues, thus preventing adverse effects of childhood obesity by promoting healthy eating habits and providing effective interventions are important. television food commercials advertising calorie-dense and high in salt and sugar foods are known to contribute unhealthy food choices and obesity. thus the proposed study will examine how the advertising intervention focusing on increasing advertising knowledge and changing affective attitudes toward commercials impacts susceptability to commercials and food decisions in youth.

Eligibility criteria:
inclusion criteria: * children had to be between 8-12.9 years old (including 8 year olds, not including 13 year olds. * had to be able to speak english as their primary language. * self-reported normal hearing and vision. exclusion criteria: * did not speak english * data from children with history of neurological conditions, clinically significant psychopathology, or learning disabilities reported by parents (e.g., attention deficit hyperactivity disorder, depression) will be excluded.
polydeoxyribonucleotide (pdrn) for cuff regeneration

Conditions: Rotator Cuff Tear

Summary: this study is to evaluate the effect of polydeoxyribonucleotide (pdrn) for healing and fatty degeneration of rotator cuff. the investigators will enroll 130 patients with rotator cuff tear who will undergo arthroscopic rotator cuff repair. 130 patients will be classified into two group. one group (pdrn) will be injected at the repaired cuff with 3cc polydeoxyribonucleotide just after surgery and be injected with another 3ml polydeoxyribonucleotide under ultrasound guidance 2 weeks after the surgery. the other group (control) will be injected with 3ml normal saline in the same manner.

polydeoxyribonucleotide is a tissue regeneration activator. it binds an adenosine receptor and stimulate vegf(vascular endothelial growth factor) synthesis and stimulate collagen synthesis. nowadays, a lot of arthroscopic rotator cuff repairs are being performed. but the failure rate of rotator cuff repair is considerably high. therefore, this study is to evaluate the effect of polydeoxyribonucleotide for healing and fatty degeneration of rotator cuff. visual analog scale (vas) of pain and other functional scores of the two group will be checked preoperatively and postoperative 3, 6, 12, 24 months. growth factors (vegf, fibroblast growth factor(fgf), insulin like growth factor(igf)) will be checked preoperatively and postoperative 1h, 2 days, 2 weeks, 6 weeks, 3, 6 months. follow up mri will be checked at postoperative 6 months. the parameters will be compared using statistical analysis.

Eligibility criteria:
inclusion criteria: * definite rotator cuff tear on preoperative mri, which needs repair * acceptance of arthroscopic surgery including rotator cuff repair exclusion criteria: * history of ipsilateral shoulder operation or fracture * concomitant neurological disorder around the

Keywords: healing fatty degeneration retear
cadasil registry study

Conditions: Cadasil

Summary: the aim of this study is to determine the clinical spectrum and natural progression of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil) and related disorders in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with cadasil , to optimize clinical management.


Eligibility criteria:
inclusion criteria: 1. sign informed consent. 2. age\>18 3. clinical diagnosis of patients with cadasil,and confirmed by genetic test or skin biopsy 4. asymptomatic notch3 mutation carriers 5. relatives of cadasil patients or carriers 6. unrelated healthy controls exclusion criteria: 1. unable to cooperate with inspectors 2. serious systemic illness, such as heart, liver, kidney disease or major mental illness 3. contraindications for imaging examination
acute comfort and blur profile of a lubricant eye drop versus a marketed eye ointment

Conditions: Dry Eye

Summary: the purpose of this study is to compare the comfort and blurriness of the investigational lubricant eye drop with a marketed artificial tear ointment.


Eligibility criteria:
inclusion criteria: * documented diagnosis of dry eye exclusion criteria: * must not have worn contact lenses within 12 hours preceding enrollment * must not have used any topical ocular drops or ointment within 24 hours preceding enrollment

Keywords: dry eye artificial tears
hydoxyurea exposure in lactation a pharmacokinetics study (helps)

Conditions: Sickle Cell Anemia

Summary: to examine the pharmacokinetics and distribution of oral hydroxyurea when administered as a single dose to lactating women


Eligibility criteria:
inclusion criteria: * lactating females, ≥ 18.0 years of age, at the time of enrollment * willingness to limit the baby's exposure to hydroxyurea through breastmilk, such as healthy volunteers using the "pump and dump" technique or avoiding direct breastfeeding or collection of pumped milk for at least 8 hours after taking the hydroxyurea dose. this applies only to healthy controls or women with sickle cell who are not already taking hydroxyurea. women with sickle cell already taking hydroxyurea may continue to breastfeed their infants. exclusion criteria: * persons with known allergies to hydroxyurea * failure to sign informed consent, or inability to undergo informed consent process * persons for whom it is not feasible or medically advisable to obtain the specimens necessary for this study

Keywords: hydroxyurea
brainstem dysfunction in covid-19 critically ill patients: a prospective observational study

Conditions: COVID-19

Summary: the purpose of this study is to determine the prevalence of brainstem dysfunction in critically ill ventilated and deeply sedated patients hospitalized in the intensive care unit (icu) for a sars-cov-s2 infection.

the recent development of the pandemic due to the sars-cov-2 virus has showed that a substantial proportion of patients developed a severe condition requiring critical care, notably because of acute respiratory distress syndrome requiring mechanical ventilation and deep sedation. outside of this coronavirus infection, this situation is classically associated with a high prevalence of brainstem dysfunction, even in the absence of brain injury. this dysfunction, either structural or functional, can be detected using appropriate clinical tools such as the brass score and/or using the quantitative analysis of ekg and eeg. crucially, brainstem dysfunction is associated not only with icu complications such as delirium, but also with a poorer survival. moreover, some reports of encephalitis cases and the presence of anosmia/agueusia raised the question of whether the virus could directly invade the central nervous system. for these two reasons, it is reasonable to assume that brainstem dysfunction is particularly prevalent in critically ill patients infected with sars-cov-2 and that this dysfunction could be one of the major determinant of patients outcome.

Eligibility criteria:
inclusion criteria: * icu hospitalization * invasive mechanical ventilation * deep sedation (rass\ 12 hours * positive sars-cov-2 pcr exclusion criteria: * history of neurologic disease (stroke, degenerative disease) * pregnant women * moribund patients * minor patient * major patient under guardianship or curatorship * prior inclusion in the study * patient not affiliated to a social security scheme * limitations and cessation of active therapies

Keywords: brainstem dysfunction delirium awareness arousal dysautonomia autonomic system sars-cov-2 covid-19 sedation mechanical ventilation eeg ekg
fosrenol post-marketing surveillance for continuous cyclic peritoneal dialysis in japan

Conditions: Hyperphosphatemia

Summary: this study is a regulatory post marketing surveillance in japan, and it is a local prospective and observational study of patients in continuous ambulatory peritoneal dialysis (capd) who have received fosrenol for hyperphosphatemia. the objective of this study is to assess safety and efficacy of using fosrenol in clinical practice. this study is also all case investigation of which the enrollment period is one year, and all patients in capd who received fosrenol for hyperphosphatemia will be recruited and followed one year.


Eligibility criteria:
inclusion criteria: * patients undergoing continuous ambulatory peritoneal dialysis who received fosrenol for hyperphosphatemia exclusion criteria: * patients who are contraindicated based on the product label

Keywords: fosrenol hyperphosphatemia continuous cyclic peritoneal dialysis
robust intelligent keyboard for quadraplegic patients

Conditions: Quadraplegia

Summary: this is multi-center prospective randomized trial evaluating the effectiveness of a new brain-computer interface for communication of quadriplegic patients in a clinical context. this performance of this will compared to traditional assistive technology (scanning system) and to performance of a healthy volunteer population.

the evaluation aims to estimate the performance of bcis in patient and healthy subjects in a clinical setting (primary objective) and to compare this performance with an existing assitive technology adapted to the target population of this study (scanning system). a quadriplegic patient population (n = 10) evaluated the two techniques and a population of healthy subjects (n = 10) evaluated the bci only. when a subject meets all the eligibility criteria and is not discarded by any non-inclusion criteria, he is included in the study. the order of the two techniques to be compared is randomized.

Eligibility criteria:
inclusion criteria: healthy volunteers: * informed consent * adults aged more than 18yo * passed complete medical check-up (heart-rate, blood pressure,...) * negative pregnancy test quadripleagic patients: * informed consent * adults aged more than 18years * passed medical exam * negative pregnancy test * full medical checkup * haemodynamic stability exclusion criteria: healthy volunteers: * history of epilepsy or seizure * auditory or visual deficit * atopic scalp dermatitis * hypersensitivity to gold * curator/guardianship/under protection of judicial authority * unable to understand the information note and/or to cooperate * no social security * can't read quadripleagic patients: * history of epilepsy or seizure * auditory or visual deficit * cerebral lesion * atopic scalp dermatitis * hypersensitivity to gold * curator/guardianship/under protection of judicial authority * unable to understand the information note and/or to cooperate * no social security * can't read * included in a different clinical trial with exclusion period

Keywords: bci tetraplegia communication p300 assistive technologie
the effects of a tourniquet in total knee arthroplasty.

Conditions: Osteoarthritis, Knee

Summary: about 5000 total knee arthroplasties (tka) are performed annually in norway. pain and reduced physical function is present in patients operated with tka up to a year after surgery and about one of five patients are not satisfied with the outcome from tka surgery. the use of tourniquet during surgery may also have impact on pain and physical function. whether tka surgery should be performed with or without the use of tourniquet, is a much-debated issue in orthopedic surgery today, and there is still no consensus in this field. this study will investigate early muscle strength and power recovery, neuromuscular recordings, neuronal changes and patient reported outcome measures after surgery with tourniquet versus not tourniquet.the findings in this study are expected to have implications for rehabilitation and the outcome of the tka surgery.


Eligibility criteria:
inclusion criteria: * knee osteoarthrosis qualifying for total knee arthroplasty exclusion criteria: * coagulation disease * rheumatoid arthritis * peripheral vascular disease * malign disease * pregnancy * on-going infection * not able to understand written and oral information in norwegian

Keywords: arthroplasty, replacement, knee tourniquets pain, postoperative muscle strength
safety and efficacy of low-dose heparinization in cerebral angiography study

Conditions: Cerebral Angiography; Heparinization

Summary: purpose: systemic heparinization is a widely used technique on digital subtraction angiography (dsa). heparin, however, is associated with a variety of complications, including hemorrhage, thrombocytopenia, and hematomas. this study aimed to investigate the safety and efficacy of micro-dose systemic heparinization or no heparinization on cerebral angiography for cerebrovascular diseases. methods: a prospective, single-blind, randomized controlled study on patients who experienced transient ischemic attacks (tias) or acute ischemic strokes and underwent dsa is performed. participants are randomized into three groups: regular-dose systemic heparinization, micro-dose systemic heparinization, and no heparinization. information on patient demographics, laboratory tests, perioperative complications, and back pain scores is collected. safety endpoints are defined as cerebral ischemic events and local complications of puncture site. efficacy endpoints were defined as the recovery of the patients.


Eligibility criteria:
inclusion criteria: 1. aged 18-65 years; 2. suspected cerebrovascular disease, including vascular lesions of the carotid, middle cerebral, anterior cerebral, vertebral, basilar, and posterior cerebral arteries; 3. activity of daily living (adl) score between 85\~100; 4. normal coagulation function and no prior anticoagulant therapy before dsa; 5. fully informed consent to participate in the study. exclusion criteria: 1. iodine allergy; 2. hepatic and/or renal insufficiency; 3. severe hypertension with poor blood pressure control; 4. hemorrhagic diseases; 5. hyperlipidemia; 6. poor glycemic control in diabetes; 7. pregnancy; 8. atrial fibrillation; 9. undergoing interventional treatment simultaneously.

Keywords: cerebral angiography heparin nursing ischemic stroke safety efficacy
definition of mutational profile of papillary thyroid tumors by mass-array

Conditions: Papillary Thyroid Cancer

Summary: somatic mutations in the map (mitogen-activated protein) kinase pathway have been found in about 80% of papillary thyroid tumors (ptcs). the evaluation of the ptc mutational profile is crucial for the definition of the prognosis and for predicting the effects of targeted and personalized therapies. molecular characterization by mass spectrometry (mass array) allows the search for multiple mutations in a single experiment, in a sensitive, fast and economic way. a mass array platform (ptc-ma) was developed, capable of identifying the presence of the most common somatic point mutations and rearrangements in ptc (pesenti et al., endocrine 2017). the aim of the study is to characterize the mutational profile of a large series of papillary thyroid carcinomas (ptc). tumor samples will be analyzed using our ptc-ma platform. the molecular profile of ptcs will be correlated with the clinical and prognostic characteristics of the patients.


Eligibility criteria:
inclusion criteria: * patients with papillary thyroid cancer * patients whose tumor tissue can be recovered for genetic analysis exclusion criteria: * patients who did not give consent * patients lost to follow-up * tumor samples not suitable for genetic analysis
noise in critical care units.impact on critically ill patients and healthcare personnel

Conditions: Noise; Adverse Effect

Summary: study noise level in the icu and its effect on both patients and healthcare personnel. use music and study same effects on same patients and healthcare personnel.

level of noise is measured and investigate its effects on delirium prevalence. sleep quality score. hemodynamics of patients. burnout and depressive symptoms of healthcare personnel

Eligibility criteria:
inclusion criteria: * patients admitted to icu fully conscious and can answer the questionnaires of the study exclusion criteria: * confused patients

Keywords: noise icu delirium depression burnout music
acute psychological effects of high intensity exercise with schizophrenia

Conditions: Schizophrenia

Summary: the purpose of this study is to study the acute psychological effects in patients with schizophrenia after one session of high intensity exercise.

we will examine if there is an acute effect of one high intensity session of physical exercise (4x4 intervals) on psychological variables state mood, state anxiety, well-being and psychological distress. this possible effect will be examined in three groups, one group being the main group that the other two groups will be compared up against. group 1: patients with schizophrenia and other psychotic illnesses. group 2: people with non-psychotic diagnosis. group 3: people without any psychological diagnosis.

Eligibility criteria:
inclusion criteria: * they will be allocated into groups by their diagnoses exclusion criteria: * not being able to complete the exercise

Keywords: schizophrenia high intensity exercise interval training exercise
china senile valvular heart disease cohort study

Conditions: Heart Valve Diseases

Summary: valvular heart diseases (vhd) are the most common causes of mortality and morbidity after coronary artery disease, hypertension, and heart failure, especially in senile patients who have more comorbidities and often require intervention. the prevalence of senile vhd is increased gradually as the growth of the age. in addition important changes have occurred as regards the presentation and treatment of the disease over recent years. however, there is little information about senile vhd in china. the purposes of this study are to evaluate the clinical characteristics, reasons for hospitalization, risk stratification, treatment modalities, quality of life and outcomes of senile hospitalized patients with vhd, to determine the risk factors affecting the prognosis, further to lay the foundation for establishing a prognosis model suitable for chinese senile vhd.


Eligibility criteria:
inclusion criteria: hospitalized patients over 60 years old meet one of the following conditions. * moderate or above valvular heart disease as defined by echocardiography: * aortic stenosis, moderate or above, or valve area ≤1.5cm2, or maximal jet velocity ≥3.0m/sec, or mean pressure gradient ≥20mmhg, * aortic regurgitation, moderate or above, or jet width ≥25% of left ventricular outflow tract, or regurgitant volume ≥30ml/beat, or regurgitant fraction ≥30%, * mitral stenosis, moderate or above, or valve area ≤2.0cm2, * mitral regurgitation, moderate or above, or effective regurgitant orifice ≥0.2cm2, or regurgitant volume ≥30ml/beat, or regurgitant fraction ≥30%, * tricuspid stenosis, moderate or above, or valve area ≤1.0cm2, * tricuspid regurgitation, moderate or above, or central jet area ≥5.0cm2, * pulmonic stenosis, moderate or above, or maximal jet velocity \>4m/sec, * pulmonic regurgitation, moderate or above, * or patients who had undergone any operation on a cardiac valve (percutaneous balloon commissurotomy, valve repair, valve replacement, transcatheter aortic valve implantation), * or diagnosis of endocarditis as assessed by duke criteria. exclusion criteria: * patients cannot be followed up for any reasons. * patients in critical condition may be die in the near future. * patients have been enrolled in this study.

Keywords: heart valve diseases cardiovascular diseases heart disease valvular heart diseases
efficacy and safety of guduchi ghan vati for covid-19 asymptomatic patients

Conditions: Covid19; Asymptomatic Condition

Summary: coronavirus disease 2019 (covid-19) has been declared global emergency with immediate safety, preventative and curative measures to control the spread of virus. confirmed cases are treated with clinical management as they are diagnosed but so far, there is no effective treatment or vaccine yet for covid-19. with recommended guidelines of ayush ministry, india, the use of ayurveda for covid-19 has increased; however, its efficacy and safety in covid-19 confirmed patients remain unclear. present study examined the efficacy and safety of one of the recommended ayurveda drug (guduchi ghan vati) compared with standard care for patients with asymptomatic covid-19 patients.


Eligibility criteria:
inclusion criteria: * age over 18 * a person diagnosed with covid-19 * asymptomatic at the time of admission exclusion criteria: * patients over 75 years * taking antibiotics or antiretroviral for any reason * mild to moderate symptoms at the time of hospital admission

Keywords: ayurveda guduchi ghan vati