Kornimate/medical-research-clean huggingface dataset:
group intervention for children with chronic tics syndrome or tourette syndrome: cbit vs psycho-educational intervention

Conditions: Tourette Syndrome; Motor or Vocal Tic Disorder, Chronic

Summary: tourette syndrome (ts) is a disorder characterized by motor and vocal tics. the most studied and promising intervention is habit reversal training (hrt) and its variations: behavioral comprehensive intervention for tics (cbit). group intervention for children with ts has not been evaluated. the aim of this study is to assess the efficacy of cbit group intervention compared with psycho-educational-supportive group in terms of tic severity.

tourette syndrome (ts) is a neuro-developmental disorder characterized by motor and vocal tics, frequently associated with behavioral and functional problems, impacting significantly on children's quality of life . current evidence supports the contribution of individual behavioral treatment for ts both for reducing tics and improving children's quality of life. the most studied and promising intervention is habit reversal training (hrt) and its variations: behavioral comprehensive intervention for tics (cbit). one of the developments of behavioral treatments is group interventions, supported in various types of psychological difficulties, adding benefit of providing peer support. however, group intervention for children with ts has not been empirically evaluated. the aim of this study is to assess the efficacy of cbit group intervention. we hypothesize that cbit group intervention will be more effective than psycho-educational-supportive (pes) group in terms of tic severity, and that both groups will be effective in quality of life measures.

Eligibility criteria:
inclusion criteria: * diagnosis of tourettes syndrome or chronic tic disorder * age 9-15 years * native hebrew speakers exclusion criteria: * intellectual disability (fsiq \< 80) * current diagnosis of substance abuse/dependence * life time diagnosis of pervasive developmental disorder, mania or psychosis. * previous treatment with 4 or more individual sessions of cbit children receiving medications for tics: eligible if the dose is stable for 6 weeks prior to study with no planned changes during study participation.
effectiveness of cervical treatment in wind musicians with temporomandibular dysfunction

Conditions: Temporomandibular Joint Dysfunction Syndrome

Summary: temporomandibular dysfunction (tmd) consists of a series of multifactorial signs and symptoms that occur in the orofacial region, with pain being the most common symptom. there is a close biomechanical and anatomical relationship between the cervical region and the temporomandibular joint (tmj) through the trigemino-spinal nucleus. objectives: to comparatively assess the improvement in subjects with tmd when adding cervical manual therapy to a postural treatment. additionally, to determine if both cervical treatments separately produce changes in the tmj. materials and methods: an experimental study of randomized controlled clinical trial type was conducted. the study involved 30 wind instrument players randomly assigned to an experimental group (eg) and a control group (cg). after obtaining consent, measurements were taken for maximum mouth opening (mmo), cervical range of motion, and pain threshold to pressure (ptp) in the masseter and temporalis muscles. both groups underwent active cervical postural treatment for 4 weeks, and the eg additionally received a cervical manual therapy protocol. an initial assessment was conducted before the intervention, and a final assessment was done one week after the last intervention. the statistical program spss was used for data analysis.


Eligibility criteria:
inclusion criteria: * acceptance of written informed consent. * playing a wind instrument. * age between 18-40 years. * pain in the cranio-cervico-mandibular region and/or masticatory muscles. * hypertrophy in the masticatory muscles. exclusion criteria: * history of trauma and/or fracture in the cranial and/or facial region. * rheumatic injury or degenerative disease. * surgical intervention on the temporomandibular joint (tmj). * malformations of the cervical or cranial spine. * vestibular, circulatory, or neurological disorders. * degenerative or infectious joint diseases. * current orthodontic treatment. * receiving physiotherapy treatment during the two weeks prior to the study or during the study.

Keywords: temporomandibular joint cervical posture wind musician
a study to investigate the pharmacodynamic effect after four-week omeprazole treatment of non-erosive reflux disease in a japanese population

Conditions: Non-erosive Reflux Disease

Summary: the purpose of this study is to investigate the pharmacodynamic effect of omeprazole n a japanese non-erosive reflux disease population


Eligibility criteria:
inclusion criteria: * patients who identified their predominant symptom as heartburn and were classifiend as grande m or n according to hoshihara's modofied version of los angeles classification at esophagogastroduodenoscopy. written informed consent, ability to comply with study instructions exclusion criteria: * patients with any ongoing gastrointestinal bleeding at the time of esopgahogastroduodenoscopy, patients with any history of erosive esophagitis or any other major diseases or concommittant drugs likely to interfere with the evaluation of this study
effects of espresso on platelet aggregability in patients with coronary artery disease

Conditions: Coronary Artery Disease

Summary: discovered thousands of years ago, coffee is among the most consumed beverages in the world. the relationship between coffee and cardiovascular risk, more specifically coronary artery disease, is controversial. platelet aggregation and its relationship with coffee is also controversial. the investigators propose this study to evaluate the relationship between coffee and platelet aggregability in patients with coronary artery disease.

30 patients with coronary artery disease (proven by previous coronary angiography) will be selected at the heart institute (incor usp) for the study. patients will be instructed to abstain from caffeinated beverages during 22 days. after this period, one group will consume caffeinated coffee during 28 days, followed by decaffeinated coffee during more 28 days and another group will start with decaffeinated coffee followed by caffeinated. all participants will receive "nespresso" coffee maker "essenza" model. the coffee "nespresso blend voluto" will be provided (caffeinated and decaffeinated). the patients will have to take four cups of espresso per day (three cups a day for patients aged 65 and over). the investigators will evaluate platelet aggregation by multiplate® (aspi, adp and arachidonic acid) and by optical aggregometry (adp and arachidonic acid).

Eligibility criteria:
inclusion criteria: * age 20 to 80 years; * coronary artery disease documented by coronary angiography; * use of aspirin 100mg. exclusion criteria: * serum creatinine dosage \> 2.5 mg/dl; * hemoglobin \<12 g/% for men and \<11 g/% for women; * platelets \ 400,000/mm3; * leukocytosis \>12,000/mm3; * fasting glycemia \>126mg/dl; * aspartate aminotransferase (ast) and/or alanine aminotransferase (alt) with values above the upper limits of normality; * consumption of more than 30 grams of alcohol per day; * active smoking or ex-smoking for less than 2 years; * use of p2y12 inhibitor; * ventricular dysfunction (left ventricular ejection fraction \<45%).

Keywords: coronary artery disease coffee platelet aggregation caffeine aggregability
the effects of accelerometer triggered functional electrical stimulation on post-stroke hemiplegic shoulder subluxation

Conditions: Post-Stroke Hemiplegic Shoulder Subluxation

Summary: post stroke hemiplegia patient have shoulder subluxation in affected side. the investigators use functional electrical stimulation in posterior deltoid and supraspinatus for prevention and treatment. but the investigators hypothesis self triggered myoelectric stimulation system has more effective for shoulder subluxation. the purpose of this study is to compare post-stroke shoulder subluxation treatment fes and triggered fes.


Eligibility criteria:
inclusion criteria: 1. within 3months after stroke 2. 1st stroke patients with hemiplegic shoulder subluxation which is measured above one finger breadth by physical examination 3. shoulder abduction strength is above p- grade (mmt) 4. male or female, ≥ 20 years of age 5. written informed consent has beed obtained 6. patients who understand purpose of this study and conform with intervention process exclusion criteria: 1. quadriplegia or double hemiplegia 2. history of injury, surgery, etc. of u/e and upper chest area 3. person who implanted metalic device(ex. pacemaker, vagus nerve stimulator) 4. patients who have lower motor neuron lesion 5. person who have difficulty using electrode due to skin problem such as skin ulcer or open wound 6. who have seizure or epilepsy history 7. female who are pregnant
study to assess efficacy and safety of nilotinib 300mg twice daily in patients with philadelphia positive chronic myeloid leukaemia (cml) in chronic phase who are intolerant to prior tyrosine kinase inhibitors.

Conditions: Philidelphia Positive Chronic Myeloid Leukaemia

Summary: the purpose of this australian study was to assess the efficacy and safety of nilotinib 300mg twice daily in patients with chronic myeloid leukemia chronic phase who were intolerant but responsive to 1st line treatment with imatinib or dasatinib. eligible patients have been previously treated with imatinib or dasatinib for at least 3 months and are experiencing non-hematologic toxicity whilst having documented responses that meet pbs authority for 1st line treatment of cml without current mr4.5.

the study was planned to enroll 130 patients to achieve the sample size requirement for a meaning full conclusion. study got terminated with 20 patients because of slow recruitment. therefore, due to small sample size, the results cannot be considered clinical significant.

Eligibility criteria:
inclusion criteria: 1. written informed consent prior to screening procedures 2. eastern cooperative oncology grou (ecog) performance status of 0, 1, or 2. 3. patient with diagnosis of ph+ cml-cp associated with bcr-abl quantifiable by rq-pcr (is). 4. patient has received a minimum of 3 months of imatinib or dasatinib treatment (any dose) since initial diagnosis with a documented response. 5. patient is eligible for pharmaceutical benefits scheme (pbs) reimbursed 1st line tki treatment. 6. patient has experienced non-hematological adverse events (ae(s)) of any grade, which persisted for at least 1 month despite supportive care or recurred at any grade at least once. patients who, at the investigator's discretion, require immediate discontinuation due to the severity of the adverse event are also eligible. 7. no other current or planned anti-leukemia therapies. 8. adequate organ function. 9. potassium, magnesium and total calcium above lower limit of normal. 10. life expectancy of more than 12 months in the absence of any intervention key exclusion criteria: 1. prior treatment with nilotinib. 2. prior accelerated phase (ap), blast crisis (bc) or allogeneic-transplant (unless the patient received an autologous transplant and was in chrionic phase (cp) prior to transplant and never in ap or bc). 3. patient has documented molecular response (mr) 4.5 at the time of study entry 4. patients with atypical bcr-abl transcript not quantifiable by standard rq-pcr. 5. known impaired cardiac function. 6. impairment of gastrointestinal (gi) function or gi disease that may significantly alter the absorption of study drug. 7. pregnant or breast feeding (lactating) women. 8. women of child-bearing potential unwilling or unable to use highly effective contraception.

Keywords: cml ph-cml leukaemia leukemia chronic myeloid leukemia chronic myeloid leukaemia tki intolerance tyrosine kinase inhibitor tyrosine kinase inhibitor intolerance
radiation and androgen ablation for prostate cancer

Conditions: Adenocarcinoma of the Prostate

Summary: a study to see how effective and tolerable radiation therapy along with androgen deprivation therapy is in treating prostate cancer.

this will be a phase i/ii study evaluating the effectiveness and toxicity of a combined regimen of 7.25 gy every other day fractions to a total dose of 36.25 gy (total of 5 fractions) with androgen deprivation therapy (adt) for 4 months total.

Eligibility criteria:
inclusion criteria: * histologically confirmed, locally confined adenocarcinoma of the prostate * patient must fit d'amico intermediate risk criteria by clinical stage (t2b-t2c), psa (prostatic specific antigen) (10-20 ng/ml), and/or gleason score (gleason 7). * the patient has decided to undergo external beam radiation as treatment choice for his prostate cancer. * signed study-specific consent form prior to registration exclusion criteria: * stage t3-4 disease. * gleason 8 or higher score. * psa \> 20 ng/ml. * ipss (international prostate symptom score) \> 15 * clinical or pathological lymph node involvement (n1). * evidence of distant metastases (m1). * radical surgery for carcinoma of the prostate. * previous chemotherapy, unless intervention was greater than 5 years from beginning treatment for current prostate cancer. * previous pelvic radiation therapy. * previous or concurrent cancers other than basal or squamous cell skin cancers or superficial bladder cancer unless disease free for at least 5 years. * history of inflammatory bowel disease. * major medical or psychiatric illness which, in the investigator's opinion, would prevent completion of treatment and would interfere with follow up. * myocardial infarction or cerebrovascular accident within one year from consultation, or other major vascular risk factor which would prevent a patient from receiving appropriate androgen deprivation therapy.11 * liver function tests (lfts) greater than twice the upper limit of normal.
immuno-nutrition supplementation in haemodialysis

Conditions: Chronic Kidney Disease Requiring Chronic Dialysis

Summary: the purpose of this pilot study is to test if an "immuno-nutrition" supplement can decrease inflammation in people on haemodialysis. this immuno-nutrition supplement is high in calories and protein like other common nutritional supplements, but also contains a unique combination of ingredients that have been shown to reduce inflammation (a problem which is caused by the body's defence \[immune\] system communicating that something is wrong) and improve the immune system in people with cancer. the research team hopes that this small study will help with gaining a good understanding of the effect of immuno-nutrition on inflammation in people on haemodialysis, which will guide and allow the research team to do a larger research study in the future.

participants will be asked to take one sachet of the immuno-nutrition supplement each day for 6 weeks. the renal dietitian on the research team will provide participants with detailed oral advice on how and when to take the immuno-nutrition supplement. participants will need to complete 3-day food diaries at the beginning, mid-way point and end of the study. the research team will measure weight, height, handgrip strength (a measure of muscle strength), body's composition of fat and muscle using a specialist scale, and skin autofluorescence levels (a measure of toxins called advanced glycation end-products). the research team will collect the results of routine blood tests. the research team will also collect and store blood samples taken before and after a haemodialysis session to measure some molecules that indicate inflammation. all of these measurements and samples will be taken at the start of the study, and after 6 weeks of taking the immuno-nutrition supplement.

Eligibility criteria:
inclusion criteria: * crp level \>5.0 mg/l. * at least three haemodialysis sessions per week for ≥3 hours using a biocompatible dialyser. * able to give informed consent. exclusion criteria: * treatment with drugs that cause immunosuppression. * non-english speakers or those with special communication needs. * pregnancy, breast feeding or intending pregnancy. * expected survival \<6 months. * hospitalisation at the time of screening. * known intolerance or allergy to ons (or isolated ingredients). * pre-dialysis serum potassium \>5.0 mmol/l. * unable to provide informed consent.

Keywords: haemodialysis systemic inflammation skeletal muscle mass immuno-nutrition
the influence of music choice on pain tolerance in the context of social background

Conditions: Pain; Analgesia

Summary: this study will investigate the effect of different music on the pain tolerance during an increasing electric stimulus in healthy individuals, taking social background into account.

the implementation of music in health care settings has shown promising results in alleviating stress, anxiety, and pain-related outcomes. however, the heterogeneity in music selection and characteristics across clinical trials has made it difficult to draw direct comparisons between different music interventions. additionally, the influence of social background on music perception remains largely unexplored, despite its potential significance. therefore, a collaboration of medical and sociological experts propose a randomized controlled trial to investigate the effects of two different music interventions on pain tolerance, taking into account the participants' social backgrounds. the primary objective of this study is to assess the impact of self-chosen and researcher-chosen music compared to a control intervention (podcast) on pain tolerance among healthy female volunteers at the outpatient clinic of the center of pain medicine, erasmus medical center, rotterdam.

Eligibility criteria:
inclusion criteria: * between 18 and 60 years of age * female * sufficient knowledge of the dutch language to understand the study documents (in the judgement of the attending physician or researcher) * provision of written informed consent by subject exclusion criteria: * significant hearing impairment * current complaints of tinnitus * current use of analgesic medication * presence of acute or chronic pain * current treatment by a medical specialist or general practitioner * history of cardiac disease of arrhythmias * (suspected) pregnancy * diagnosed psychiatric or neurological impairments * electric implants (e.g. pacemakers)

Keywords: music pain analgesia music-induced analgesia socioeconomic status cultural capital
connective tissue diseases and lung manifestations

Conditions: Connective Tissue Diseases; Interstitial Lung Disease; Systemic Sclerosis

Summary: despite a number of prospective studies already initiated in the past years, the current epidemiology and course of interstitial lung disease (ild) and pulmonary hypertension (ph) in patients with connective tissue disease (ctd) is still not well defined, particularly regarding its prevalence, incidence and the management of a broad spectrum of disease presentations. major challenges include the identification of patients with progressive disease, the appropriate time point of therapeutic intervention and the underlying driver of disease (inflammatory or pro-fibrotic stimulus or both?). to address these issues in western austria, a progressive registry of patients with ctd exploring routine clinical and pathophysiological characteristics of ild and ph will be conducted. this multidisciplinary, prospective and observational registry aims to collect comprehensive clinical data on incidence, prevalence and course of disease regarding all ph and ild presentations in a real-world setting.

specifically, this registry will collect demographic data, disease-related clinical data, routine laboratory values (including antibody-profile and iron status), diagnostic procedures, significant comorbidities, therapeutic managements (e.g. thoracic ultrasound, hrct), and disease outcomes over 10 years. in addition, blood biobank samples for translational research will be collected in a subgroup of patients with systemic sclerosis over serial time points to study the systemic inflammatory and profibrotic phenotype of patients. in summary, this registry will monitor the disease course of pulmonary manifestations of patients with ctd and may be hypothesis-generating and provide new insights in underlying inflammatory/pro-fibrotic patterns.

Eligibility criteria:
inclusion criteria: * the inclusion criteria are adult patients (≥18 years) diagnosed with ctd with signed informed consent. exclusion criteria: * exclusion criteria are patients with a serious co-morbidity interfering with the course of interstitial lung disease or pulmonary hypertension.
acute cardiovascular responses to a single exercise session in patients with post-covid-19 syndrome

Conditions: Post-Acute COVID-19 Syndrome

Summary: the objective of the study is to compare the acute cardiorespiratory and perceptual responses to a physical exercise session in those infected by covid-19 with and without persistent symptoms.

the study will be a crossover carried out in two groups (with and without persistent symptoms of covid-19). participants in both groups will undergo a control session and an exercise session and cardiorespiratory and perceptual responses will be obtained before, during and after the sessions. in the exercise session, participants will perform aerobic exercises, strength exercises and muscle stretching, while in the control session participants will remain seated. blood pressure, heart rate, cardiac autonomic modulation, peripheral oxygen saturation, vascular function and perception of affect will be obtained.

Eligibility criteria:
inclusion criteria: post-covid syndrome group: * have had a positive rt-pcr test for covid-19; * present persistent symptoms of post covid 19 syndrome, which have no other health explanation according to the criteria of the world health organization (who); * have the cognitive and physical capacity to perform the exercises; it is * low cardiovascular risk classification according to the american college of sports medicine criteria. healthy group: * not present persistent symptoms of post covid 19 syndrome, which have no other health explanation according to the criteria of the world health organization (who); * have the cognitive and physical capacity to perform the exercises; it is * low cardiovascular risk classification according to the american college of sports medicine criteria.

Keywords: post-covid 19 syndrome covid-19 fatigue cardiovascular system respiratory system rehabilitation