Kornimate/medical-research-clean huggingface dataset:
total shoulder arthroplasty near-infrared spectroscopy

Conditions: Cerebral Ischemia

Summary: the purpose of this study is to measure cerebral oxygenation and cardiac output of total shoulder replacement patients undergoing general anesthesia (ga) and positive-pressure ventilation (ppv). we hypothesize that cerebral desaturation occurs frequently during ga with ppv, but is rare during ga and spontaneous ventilation. we also hypothesize that cardiac output usually is well maintained under ga in the sitting position when epinephrine is used, but that decreased cardiac output increases the risk of cerebral desaturation.


Eligibility criteria:
inclusion criteria: * patients 18-99 undergoing total shoulder arthroplasty * planned general anesthesia + brachial plexus nerve block * planned arterial catheter exclusion criteria: * patients younger than 18 years older and older than 99 * patients not intending to receive general anesthesia and peripheral nerve block * indication for endotracheal tube * bmi ≥ 30 * ejection fraction (if known) \< 50% * known significant restrictive or obstructive pulmonary disease * patients with a history of transient ischemic attack (tia) or stroke * patients with recent signs or symptoms of myocardial ischemia * current stress test positive for ischemia * intolerance to study medications * pre-existing contraindication to regional anesthesia * infection at block site * pre-existing neurological injury to operative limb * non-english speaking patients
surgical outcome of hcc with portal vein tumor thrombosis on the basis of risk scoring

Conditions: Hepatocellular Carcinoma; Portal Vein Thrombosis; Prognosis

Summary: the goal of this multicenter retrospective cohort study is to investigate the clinical outcomes and prognostic factors after hepatic resection in patients with hcc exhibiting pvtt, and to develop a prognostic index that can be helpful in determining the treatment strategy.

hepatocellular carcinoma (hcc) frequently invades the surrounding liver vasculature, with portal vein tumor thrombosis (pvtt) being the most common form of macrovascular invasion. at the time of hcc diagnosis, pvtt is detected in approximately 10%-40% of patients and is associated with an extremely poor prognosis. in most staging systems and guidelines, hcc with pvtt, regardless of the extent of the tumor, is classified as an advanced stage, and surgical resection is not recommended as the first-line treatment. instead, consensus guidelines such as those from the american association of study of liver disease(aasld), the asian pacific association for the study of liver(apasl), and the european association for the study of liver(easl) recommend systemic and targeted therapy for these patients. despite these recommendations, experienced liver centers in asia have been attempting surgical resection for some patients with hcc exhibiting pvtt, and the outcomes are favorable in selected patients. however, most of the studies were conducted in only one center, had a small sample size, and obtained undesirable surgical treatment outcomes in most of the patients. thus, surgical resection has not yet been widely accepted as an effective treatment for patients with hcc and pvtt. in addition, a prognostic index that can indicate which surgical resection is beneficial in comparison with nonsurgical treatment remains unestablished. a randomized controlled trial could be the best way to compare the outcomes of surgical resection and nonsurgical treatments, but it is difficult to conduct because of difficulties in ethical approval and allocation concealment. therefore, adequate studies with large sample sizes are needed to clarify the benefits of surgical resection in patients with hcc and pvtt and the prognostic index, which can specify the criteria for surgical resection in these patients. this study aimed to investigate the clinical outcomes and prognostic factors after hepatic resection in patients with hcc exhibiting pvtt, and to develop a prognostic index that can be helpful in determining the treatment strategy.

Eligibility criteria:
inclusion criteria: the patients underwent liver resection for hcc with portal vein tumor thrombosis between jan 2005 and dec 2019 at 10 university-affiliated hospitals in south korea. exclusion criteria: * metastatic cancer \& extrahepatic metastasis * intrahepatic cholangiocarcinoma * mixed type hepatocellular-cholangiocarcinoma * recurred hepatocellular carcinoma * not available medical records. * child-pugh classification b or c

Keywords: hepatocellular carcinoma portal vein tumor thrombosis prognosis hepatectomy
a study of ro4905417 in patients with non st-elevation myocardial infarction (non-stemi) undergoing percutaneous coronary intervention

Conditions: Myocardial Infarction

Summary: this randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of ro4905417 in patients with non st-elevation myocardial infarction (non-stemi) undergoing percutaneous coronary intervention (pci). patients will be randomized to receive an intravenous infusion of either 5 mg/kg ro4905417 or 20 mg/kg ro4905417 or placebo before pci. follow-up will be for 4 months.


Eligibility criteria:
inclusion criteria: * adult patients, \>18 to \<75 years of age * non st-elevation myocardial infarction * woman of childbearing potential will be allowed only if using two acceptable methods of contraception * body mass index (bmi) \</= 40 kg/m2 exclusion criteria: * acute st-elevation myocardial infarction (stemi) * culprit coronary lesion with a total thrombotic occlusion or a lesion requiring the use of distal embolization protection or thrombectomy devices * percutaneous coronary intervention (pci) within the past 72 hours * thrombolytic therapy within the past 7 days * major surgery within the past 3 months * history of cerebral vascular disease or stroke in the past 3 months * bleeding disorders * inadequately controlled severe hypertension * prior coronary artery bypass graft (cabg) surgery * decompensated heart failure (oedema and/or rale) * acute infection at screening or active chronic infection within 3 months prior to pci * patients known to be hiv positive, patients receiving antiretroviral drugs, or immuno-suppressed patients * uncontrolled diabetes mellitus (hba1c \>10%) at baseline
the interaction between appetite hormones

Conditions: Obesity

Summary: glucagon like peptide (glp) -1 affects metabolic response corrected for weight change

many obese people have had several successful weight losses, however very few can maintain the weight loss over a longer period (e.g. one year) therefore, we want to investigate the metabolic response and the importance for maintenance of weight loss in obese people, who lost at least 7, 5 % body weight by low calorie diet followed by 52 weeks of diet weight maintenance with or without supplement of glp-1.

Eligibility criteria:
inclusion criteria: * bmi \> 30 and \< 40 (kg/m2) * healthy exclusion criteria: * other known illness * medicine that affects glucose- and lipid metabolism, appetite or food intake * pregnancy * breast feeding
varenicline (chantix) treatment for waterpipe smoking cessation

Conditions: Nicotine Dependence

Summary: the lack of proven waterpipe smoking cessation interventions makes it important to explore interventions proven effective for cigarette smoking cessation. the investigators hypothesize that varenicline (chantix) administrated for 12 weeks is associated with higher sustained quit rate at 12 weeks compared to placebo. the investigators propose to conduct a randomized double-blind placebo-controlled trial that will evaluate the effect of varenicline (chantix), in two parallel groups each consisting of 76 habitual waterpipe smokers who are willing to quit. potential participants will be approached in cafés, word-of-mouth and through media and will be invited to the american university of beirut medical center to complete study procedures. both study groups will receive the same behavioural intervention in combination with either varenicline (chantix), an fda approved drug indicated for use as an aid to smoking cessation treatment, or placebo. participants will complete study procedures in four visits. during visit-1 the informed consent process, baseline assessments and randomization will be completed and varenicline (chantix) or placebo will be initiated together with the behavioural interventions. the behavioural intervention will be continued over the next 2 visits. an end of treatment visit 12 weeks after quit date will be dedicated to assessing sustained quit rate and other outcomes.


Eligibility criteria:
inclusion criteria: * daily waterpipe smokers from the community of beirut, * aged 18 years or older * willing to quit exclusion criteria: * cigarette and/or cigars smokers, * active malignancy * pregnant women

Keywords: waterpipe smoking nicotine dependence smoking cessation varinecline, chantix therapy behavioral therapy
split scar study to assess cosmetic outcome from differing suture spacing

Conditions: Suture, Complication; Wound; Wound Complication; Wound Dehiscence; Wound of Skin; Surgery; Suture; Complications, Infection or Inflammation

Summary: the investigators wish to determine how suture spacing (5 mm vs. 10 mm) affects cosmetic outcome and development of "train tracking" in wounds. linear wounds with sutures spaced closer together may not be as cosmetically appealing when compared to those that have larger spacing between sutures. suturing closer together constricts blood flow and increases tension that ultimately results in more tissue necrosis and a less appealing outcome. the investigators also aim to conclude if 5 mm or 10 mm suture spacing results in less complications.


Eligibility criteria:
inclusion criteria: * male and female patients, at least 18 years of age, undergoing surgical excision of biopsy-proven skin cancers on the trunk or extremities at silver falls dermatology \& allergy outpatient clinic in salem, oregon. patients with elliptical excisions with length greater than 4.0 centimeters were included. exclusion criteria: * patients with prior scars within 2.5cm of the proposed elliptical excision, failure to comply with wound care instructions or failure to follow up.
influence of preconceptional obesity on the myometrial cells differentiation toward a contractyl phenotype

Conditions: Pregnancy Complication

Summary: the purpose of this study is to improve the understanding of cellular mecanism involved in delivery disorders in obese women, first by characterizing the hyperplasia phenomenon of myometrail cells induced by inflammatory stimulation (il-1b), then by studying the role of blood mononuclear cells, of leptine and of obese women sera to interfere with the transition of myometrial cells toward hyperplasia phenotype.


Eligibility criteria:
inclusion criteria: * informed consent signed * patient affiliated with a social security scheme * in front of for obstetrical reasons to give birth by caesarean section (scheduled caesarean section) * or a woman who is not obese in labour and needs to undergo a cesarean section * no obvious infectious context * age \> 18 years old exclusion criteria: * obvious inflammatory or autoimmune diseases * suspected or confirmed infectious context, including virale infection vih, vhc, vhb * coagulation disorders

Keywords: pregnancy obesity differentiation
a double-blind, randomized conversion to monotherapy study to evaluate the efficacy and safety of brivaracetam in subjects (≥ 16 to 75 years old) with partial onset seizures

Conditions: Epilepsy

Summary: antiepileptic drugs (aeds) are the main treatment for epilepsy; however, only a limited number of aeds are approved for use as monotherapy. the objective of this study is to evaluate the efficacy of brv in the conversion of partial onset seizure patients from combination treatment to monotherapy.


Eligibility criteria:
inclusion criteria: * subjects from 16 to 75 years, both inclusive * well-characterized focal epilepsy or epileptic syndrome * subjects having at least 2 but not exceeding 40 partial onset seizures, whether or not secondarily generalized per 4 weeks during the 8-week baseline period * subjects on a stable dose of at least 1 but no more than 2 concomitant antiepileptic drugs (aeds) with the second aed ≤ 50% of the minimum recommended maintenance dose exclusion criteria: * seizure type ia non-motor as only seizure type * history or presence of seizures occurring too frequently or indistinctly separated to be reliably counted during the 6 months preceding visit 1 or during baseline * other serious uncontrolled disease

Keywords: epilepsy; monotherapy partial onset seizures adults and adolescents
safety of btds in subjects with osteoarthritic (oa) pain of hip or knee: a 6-month open-label extension phase

Conditions: Osteoarthritis

Summary: the purpose of the extension phase is to evaluate the long-term safety and tolerability of buprenorphine transdermal system (btds).

buprenorphine is a synthetic opioid analgesic with over 25 years of international clinical experience indicating it to be safe and effective in a variety of therapeutic situations for the relief of moderate to severe pain. transdermal systems may offer advantages over currently indicated oral products including ease and convenience of use, improved compliance, possible reduction in patient care, and prolonged and consistent delivery of drug.

Eligibility criteria:
inclusion criteria: * subjects with moderate to severe osteoarthritic (oa) pain who completed all visits of the double-blind phase on study drug, or who discontinued study drug due to lack of therapeutic effect in the double-blind phase, but still completed all visits of the double-blind phase off study drug, are eligible to enroll in the extension phase. exclusion criteria: * excluded from the study are subjects who ingest \> 2500 mg/day acetaminophen as part of their current stable nonopioid analgesic regimen. * subjects requiring long-acting opioid analgesics \[once- or twice-daily dosing with an every (q) 24 hour (h) or q12h drug\] or transdermal fentanyl during the extension phase should be discontinued from the study. refer to core study for additional inclusion/exclusion information.

Keywords: osteoarthritis opioid transdermal
the effect of thermotherapy on recovery and performance

Conditions: Healthy

Summary: this study investigates the effects of cooling on the recovery and performance characteristic in young healthy subjects. the study is divided in two projects: project a: investigates the effects of 20 min. post-exercise cooling on vertical jump performance and delayed onset muscle soreness and rated perceived exertion. project b: investigates the effects of 20 min. pre-exercise cooling on maximal voluntary contraction of the right m. quadriceps femoris and delayed onset muscle soreness and rated perceived exertion.

the aim of this study is to investigate the effects of a 20 min. external cooling application (+8°c ) versus a external thermo neutral application (+32°c) up to 72 hours post application. the study is divided in two projects: project a: this study is focusing on the recovery process after a max. jump performance (3x30 counter movement jumps). directly after the exercise subjects receive a cooling or thermo-neutral application. recovery characteristics measured by vertical jump performance (objective) and delayed onset muscle soreness and rated perceived exertion (subjective) are measured in function of time up to 72 hours post cooling intervention. project b: this study is focusing on the effect of 20 min. cooling or thermo-neutral application on the m. quadriceps femoris performance (mvc). after the thermo-application, the 60% endurance mvc is measured by means of surface emg (ot bioelettronica 10-750 hz) in a ergometer chair 90° degrees knee flexion (cor 1 bioelettronica). muscle conduction velocity, mvc (objective), delayed onset muscle soreness and rated perceived exertion (subjective) are measured in function of time up to 72 hours post thermo-application.

Eligibility criteria:
inclusion criteria: * only healthy young subjects 18-30 years * no musculoskeletal surgery in trunk and lower extremities * injury history in trunk and lower extremity for more than one year * subjects taking anticonceptive medication are allowed to participate exclusion criteria: * actual injuries or injuries for less than one year in trunk and /or lower extremities * injury history in trunk and lower extremity for more than one year with complaints * anxiety of cooling * subjects on medication * pace maker * cardiovascular disease * pregnancy * skeletal problems * appendectomy for less than two years * morbus raynaud syndrome

Keywords: cryotherapy recovery athletic performance maximum voluntary contraction rated perceived exertion delayed onset muscle soreness jump performance
study of the enteric nervous system using colonic biopsies in parkinson patients with lrrk2 mutation

Conditions: Parkinson's Disease

Summary: the clinical and pathological similarities between lrrk2 related parkinsonism and idiopathic parkinson's disease (pd) indicate that monogenetic lrrk2 parkinsonism may be a paradigm for the development of lewy bodies disease, and a careful look at discrepancies between these two conditions may provide insight into the pathogenesis of pd. the early involvement of the enteric nervous system (ens) during pd led to theories that an as yet unidentified external agent entering the ens causes pd . if lesions of the ens are found in patients who present with a genetic form of parkinsonism would go against this notion, and thus provide insight to the pathophysiology of the disease.


Eligibility criteria:
inclusion criteria: * patients aged 30-80, both genders * parkinson's disease patients * parkinson's disease patients with g2019s mutations * controls: patient at risk of colic cancer for whom a coloscopy is required

Keywords: parkinson's disease gut colon biopsies lrrk2
clinical efficacy and safety of laparoscopic sleeve gastrectomy in obese patients with pcos

Conditions: Polycystic Ovary Syndrome

Summary: this study aims to evaluate the clinical efficacy and safety in obese patients with polycystic ovary syndrome after laparoscopic sleeve gastrectomy.

this study aims to evaluate the clinical efficacy and safety of laparoscopic sleeve gastrectomy in obese patients with polycystic ovary syndrome（pcos). about 100 obese patients with pcos and 100 simple obese patients (without complications) were enrolled. all pcos patients with obesity underwent lsg. a multidisciplinary team evaluated participants with obesity at baseline, 1, 3, 6, 12, 24, and 36 months after lsg. anthropometrics, metabolic indicators, sex hormones, menstruation，glucose-lipid metabolic markers, and hepatic steatosis were measured baseline and postoperative.

Eligibility criteria:
inclusion criteria: * age ranged from 18\~45 years old, * bmi over 37.5 kg/m2, or bmi over 32.5 kg/m2 with diabetes which meets the recommended cutoff for bariatric surgery of the guidelines for surgical treatment of obesity accompanied with or without type 2 diabetes in china. exclusion criteria: * outside of the 18-45 age range; * secondary obesity caused by endocrine disorders; * history of more than one bariatric procedure; * severe hepatic, renal or heart dysfunction; * mental illnesses or intellectual disability. * pregnancy or lactation * contraindications for laparoscopic surgery, such as gastrointestinal diseases of intra-abdominal infection, adhesions, etc.,

Keywords: polycystic ovary syndrome laparoscopic sleeve gastrectomy obesity menstrual cycle
pre-hospital hypoxemia in trauma patients

Conditions: Trauma

Summary: the intent of this study is to describe the proportion of trauma patients requiring oxygen before hospital arrival, the amount of oxygen they require, and whether or not the oxygen is beneficial to outcomes.

trauma patients in the united states frequently receive high-flow high-concentration supplemental oxygen in the pre-hospital setting, yet their physiologic need is rarely known. providing oxygen to everyone regardless of need may seem straightforward, but the practice has extensive implications in logistically challenging areas such as a combat arena or mass casualty event, and is not supported by care guidelines. indeed, too much oxygen can be harmful for some patients.1, 2 if it is the case, that not all trauma patients require oxygen, this would decrease the logistical burden of providing oxygen in the pre-hospital environment. no study has yet been performed that describes the proportion of patients requiring oxygen, the amount of oxygen they require, and whether or not oxygen is beneficial to outcomes. this prospective observational cohort investigation aims to bridge the knowledge gap surrounding the need and possible benefits or harms arising from oxygen therapy. in our emergency medical services (ems) systems, the written standard of care is to provide oxygen only to maintain oxygen saturation at 95% or when hemorrhagic shock or traumatic brain injury are suspected.3 we will observe patterns of oxygen treatment and outcome for patients treated according to this written standard of care, and compare this to the treatment and outcomes for patients transported by ems units who continue their usual practice pattern. specifically, we aim to: 1. identify the proportion of trauma patients who are hypoxemic or who have traumatic brain injury or hemorrhagic shock at the time of initial ems contact 2. identify the proportion of trauma patients who develop hypoxemia or hemorrhagic shock while in the pre-hospital setting 3. identify differences in clinically important outcomes associated with treatments driven by written standard of care compared with the usual practice pattern of ems units. these outcomes include requirement for advanced airway management, hospital and intensive care unit lengths of stay, and disposition (including in-hospital and 30-day mortality) 4. determine the amount of oxygen (liters per minute) required to reverse hypoxemia

Eligibility criteria:
inclusion criteria: * acute traumatic injury * transported directly to study hospital * meets at least one trauma consult/trauma stat criteria exclusion criteria: * lack of continuous peripheral pulse oximetry data * age \<18 years * on prescribed home oxygen therapy prior to trauma

Keywords: prehospital, oxygen, trauma, hypoxemia
recombinant factor viia in acute intracerebral haemorrhage

Conditions: Acquired Bleeding Disorder; Intracerebral Haemorrhage

Summary: this trial is conducted in asia, europe, middle east, north america, oceania, and south america. the purpose of this study is to evaluate the treatment of recombinant factor viia (eptacog alfa (activated)) in patients with acute intracerebral bleeding. it is expected that more patients will recover without severe permanent disability after acute treatment with recombinant factor viia by reducing further intracerebral bleeding.


Eligibility criteria:
inclusion criteria: * spontaneous intracranial hemorrhage (ich) within 3 hours after first symptom exclusion criteria: * patients with secondary ich * pre-existing disability * haemophilia