Kornimate/medical-research-clean huggingface dataset:
hypothermia risk prediction combined with active insulation management in geriatric surgery

Conditions: Hypothermia; Anesthesia; Body Temperature Changes

Summary: to evaluate the effectiveness and safety of hypothermia risk prediction combined with active warming management to reduce intraoperative hypothermia in elderly patients undergoing elective general anesthesia, improve the quality of anesthesia management, and enhance patients' awareness of the work of anesthesiologists.


Eligibility criteria:
inclusion criteria: 1. age ≥ 60 years, male or female. 2. elective general anesthesia for surgery. 3. operative time ≥ 30 min. 4. preoperative body temperature within the normal range. 5. normal preoperative bleeding and clotting time. exclusion criteria: 1. mental illness. 2. high or low basal hypothermia with high or low metabolic disease (patients with central hyperthermia include those with cerebrovascular vascular disease, traumatic brain injury and brain surgery, epilepsy, central hyperthermia due to acute hydrocephalus; thermoregulatory abnormalities including malignant hyperthermia (mhs), neuroleptic malignant syndrome and those with definite evidence of diagnosed hypo- or hyperthyroidism and current abnormal thyroid function). 3. impaired skin insulation barriers such as large skin burns. 4. infectious fever. 5. other causes of body temperature above 38.5 °c three days before surgery. 6. other persons deemed unsuitable by the investigator to participate in the clinical trial. 7. refusal to sign the informed consent form.
does small intestinal bacterial overgrowth contribute to functional dyspepsia

Conditions: Functional Dyspepsia; Small Intestinal Bacterial Overgrowth; Chronic Abdominal Discomfort

Summary: the prevalence of functional dyspepsia (fd) is estimated to be 15% of the adult population. fd is commonly described as a condition of chronic abdominal discomfort localized to the upper abdomen. postprandial bloating, pain, nausea, vomiting, belching, and early satiety are common symptoms of the fd patient. fd is defined by \>12 weeks of symptoms, which need not be consecutive, within the preceding year consisting of a) persistent or recurrent dyspepsia and b) an absence of organic disease after a gastrointestinal endoscopy or x-ray series. fd is therefore considered a disorder of function because no mucosal pathology is seen in these patients, as in patients with other functional disorders such as irritable bowel syndrome (ibs) and fibromyalgia (fm). there is a remarkable degree of overlap among these three disorders. these 3 disorders share the finding of hypersensitivity and the symptom of postprandial bloating to suggest the possibility of a common origin.


Eligibility criteria:
inclusion criteria: * must have fd based on the most recent umbrella criteria of one or more of: a. bothersome postprandial fullness, b. early satiation, c. epigastric pain, d. epigastric burning * no evidence of organic disease (including h. pylori detected at time of endoscopy) that is likely to explain the symptoms * criteria must be fulfilled for the last 3 months with symptom onset at least 6 months before the diagnosis * the physical exam, routine blood tests including cbc, chemistry panel and liver tests, upper gastrointestinal endoscopy and 24h ph study must be normal exclusion criteria: * history of ibs,rheumatoid arthritis,h. pylori infection,lupus,peptic ulcer, cirrhosis,diabetes, hiv or tb * inflammatory bowel disease * bowel resection (including gastric, small bowel or colon; gallbladder surgery or appendectomy are not exclusion criteria) * anti/pro-biotics last 3 months * previous lbt (lactulose breath test) * narcotic dependence * pregnancy * control subjects will be excluded if they have symptoms of heartburn, retrosternal chest pain, chronic cough, nausea or regurgitation suggestive of gastroesophageal reflux disease

Keywords: functional dyspepsia small intestinal bacterial overgrowth chronic abdominal discomfort
study of durvalumab + tremelimumab, durvalumab, and placebo in limited stage small-cell lung cancer in patients who have not progressed following concurrent chemoradiation therapy

Conditions: Small Cell Lung Cancer

Summary: this is a phase iii, randomized, double-blind, placebo-controlled, multi-center, international study of durvalumab or durvalumab and tremelimumab as consolidation treatment for patients with ls-sclc who have not progressed following concurrent chemoradiation therapy


Eligibility criteria:
inclusion criteria: 1. histologically or cytologically documented limited-stage small cell lung cancer (stage i-iii). 2. received 4 cycles of chemotherapy concurrent with radiotherapy, which must be completed within 1 to 42 days prior to randomization and the first dose of ip. chemotherapy must contain platinum and iv etoposide. radiotherapy must be either total 60-66 gy over 6 weeks for the standard qd regimen or total 45 gy over 3 weeks for hyperfractionated bd schedules. 3. pci may be delivered at the discretion of investigator and local standard of care, and must be conducted after the end of ccrt and completed between 1 to 42 days to first dose of ip. 4 .have not progressed following definitive concurrent chemoradiation 5 .life expectancy ≥ 12 weeks at day 1. 6. ecog 0 or 1 at enrolment. exclusion criteria: 1. extensive-stage sclc 2. active or prior documented autoimmune or inflammatory disorders 3. uncontrolled intercurrent illness, including but not limited to interstitial lung disease. 4. active infection including tuberculosis, hiv, hepatitis b and c 5. patients who received sequential chemotherapy and radiotherapy (no overlap of rt with chemotherapy)

Keywords: small cell lung cancer sclc ls-sclc limited stage carcinoma lung cancer
age-related prevalence of sleep respiratory disturbances

Conditions: Lung Diseases; Heart Diseases; Hypertension; Sleep Apnea Syndromes

Summary: to determine the prevalence and longitudinal course of sleep apnea among men and women and to examine the associations of apnea, oxygen desaturation, snoring, high blood pressure, and other biomedical correlates.

background: sleep apnea is characterized by repetitive cessations of respiration during sleep with consequent decreases in arterial oxygen saturation. sleep apnea can be caused by upper airway obstruction or by central nervous system failure to sufficiently excite the diaphragm and accessory respiratory muscles. however, in most cases, both processes are involved. hypopneas, in which airflow is significantly compromised without complete cessations of respiratory flow, and snoring are often found in association with apneas. both apneas and hypopneas cause repetitive disruptions of sleep, consequent daytime somnolence, and complex cardio-respiratory disturbances. design narrative: the study was longitudinal in design. a stratified random sample of adults in san diego was used to examine risk factors in the prevalence of sleep respiratory disturbances. a structured random sample was selected by random digit telephone dialing. subjects were studied in their homes. some were followed yearly during the project. each volunteer gave a brief sleep history and medical review, including blood pressure measurement, the national interview survey, and quality of well-being scale. blood oxygen saturation, pulse rate, snoring, and sleep duration were recorded for three nights. state-of-the-art computerized pulse oximeters and microprocessor-based activity/light monitors were used. subjects found to have the most severe sleep respiratory disturbances underwent laboratory polysomnograms to add descriptive data and to validate the survey methodology. the prevalence of respiratory disturbances in sleep was analyzed as a function of age and sex. associations with several aspects of morbidity were determined. the longitudinal course of respiratory disturbances in sleep were examined. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
study of first-line treatment patterns and clinical outcomes in patients with advanced melanoma in the united kingdom

Conditions: Melanoma

Summary: the purpose of this study is to describe the first-line therapy landscape for patients with advanced melanoma and to describe clinical outcomes and healthcare resource utilization in a subset of treatment-naïve patients who initiated nivolumab + ipilimumab combination therapy.


Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * patient has medical chart documentation of advanced (unresectable or metastatic) melanoma. * patient initiated a first-line therapy for the treatment of advanced melanoma during the eligibility period (01 july 2016 to 01 july 2017; index event). * patient did not receive systemic treatment for their advanced (unresectable or metastatic) melanoma prior to index event * patient initiated first-line therapy at least six months before the date their chart abstraction initiated exclusion criteria: * patient was enrolled in an investigational drug clinical trial or participating in medical research judged to directly affect how the patient was being monitored/treated while receiving first-line therapy * patient had another active concurrent malignancy other than advanced melanoma, which required systemic treatment at the time of index event * part or all of the patient's first-line treatment was received at a different site and the patient's medical chart pertaining to this care is not accessible * patient medical chart is missing, empty, or not retrievable other protocol defined inclusion/exclusion criteria could apply
fascia iliaca block for postoperative pain control after elective hip arthroplasty

Conditions: Hip Osteoarthritis

Summary: this clinical trial aims to assess the analgesic efficacy of ultrasound-guided fib using different analgesic combinations administered into the iliac fascia compartment. the main question it aims to answer is: ·what is the total morphine (mg) consumption at 24 hours postoperatively for each of the three groups? the secondary questions are: * what is the length of stay in hospital for each group? * what is the risk of falling associated with the use of fascia iliaca block? researchers will compare two analgesic combinations of local anesthestic naropin 0,25% versus dextrose 10% administered by fascia iliaca block for postoperative pain after total hip arthroplasty.

the investigators plan to conduct a single-center, prospective, blinded, randomized controlled study of 150 eligible patients undergoing elective tha via a miniinvasive anterior approach starting june 2024. all patients will receive spinal anesthesia and preoperatively fib for analgesia. the investigators define randomly three patient groups: group 1, receiving 40 ml naropin 0,25% in saline, group 2, receiving 40 ml naropin 0,25% in dextrose 5%, and group 3, receiving 40 ml dextrose 10%. after the regression of spinal anesthesia, all the patients receive the same multimodal pain therapy according to the visual analog scale (vas), including paracetamol iv, nsaid, and morphine, according to the pain protocol in our hospital. the primary endpoint of the study is total morphine (mg) consumption at 24 hours postoperatively, and the secondary goals were length of stay and the risk of fall.

Eligibility criteria:
inclusion criteria: * indication of total primary hip arthroplasty * asa i-iii * bmi\<40 kg/m2 exclusion criteria: * inability or refusal to sign informed consent * known allergies to any of the drugs used in the study * hepatic or renal insufficiency * gastritis or gastroduodenal ulcer * opioid dependency * coagulopathy * pregnancy * scars in the surgery and fascia iliaca block areas * clinical evidence of peripheral neuropathies.

Keywords: fascia iliaca block postoperative pain
assessment of emotion regulation strategies used when suicidal

Conditions: Suicidal Ideation; Treatment Refusal; Emotion Regulation

Summary: crisis response planning is an efficacious, one-session intervention that increases positive affect, decreases negative affect and psychiatric hospitalizations, and reduces suicide attempts by 76% among servicemembers. crisis response planning is hypothesized to reduce suicidality by identifying a variety of personalized strategies that are designed to strengthen and/or promote emotion regulation processes.research in nonmilitary samples suggests the effectiveness of emotion regulation strategies varies across situations. the applicability of these findings to suicidality among servicemembers is unknown. improved understanding of what strategies work under which circumstances and for whom will significantly advance our ability to prevent suicide among servicemembers. hypotheses include: 1. use of self-management strategies, thinking about reasons for living, and seeking social support at time t will be associated with significant reductions in suicidal ideation at time t+1. 2. use of distraction, reappraisal, and interpersonal emotion regulation strategies at time t will be associated with significant reductions in suicidal ideation at time t+1. 3. affect intensity and social context will significantly moderate the time-lagged effects of crisis response planning and emotion regulation strategy use on suicidal ideation. 4. distinct profiles of demographic (e.g., gender, age), historical (e.g., prior suicide attempts), and psychological characteristics (e.g., emotion dysregulation, symptom severity) will predict who experiences a decrease in suicidal ideation following the use of crisis response planning and emotion regulation strategies. 5. (exploratory): individuals who utilize their crisis response planning more frequently and perceive crisis response planning as more effective will be more likely to engage in mental health treatment at follow-up.


Eligibility criteria:
inclusion criteria: * currently serving in any branch or component of the u.s. military * \>18 years old; * score ≥ 5 on the scale for suicidal ideation and/or endorse a suicide attempt, aborted attempt, or interrupted attempt within the past month on the self-injurious thoughts and behaviors interview-revised (sitbi-r) * ability and willingness to complete research-related activities remotely * regular access to an android or apple smartphone that is compatible with the ecological momentary assessment application exclusion criteria: * engagement in mental health treatment within the past year (including taking psychotropic medications) * a psychiatric or medical condition that preventing providing informed consent or from participating in the treatments (e.g., psychosis, mania, acute intoxication); or - expecting to separate from the military within 90 days
neurodevelopmental outcomes of preterm and term children

Conditions: Development

Summary: this study will utilize two validated tools for assessing child development and behavior, to investigate the outcomes for children born preterm compared with those born at full term. two hundred children born or cared for during the neonatal period at mount sinai hospital will be enrolled. parents will be asked to complete a behavioral assessment questionnaire, and which will assess development in an examination administered by a trained occupational therapist at mount sinai hospital.

this research will be completed at mount sinai hospital. all participants will be identified from mount sinai hospital records of infants born at msh and/or cared for in the mount sinai nicu on or after january 1, 2011, at full term or preterm. the study team will contact the parents of eligible potential participants by telephone to explain the study and ask if the parent will consent to their child's participation. if the parent agrees, we will make an appointment for the child to come to mount sinai for the evaluation using the bayley-iii. the parents will be mailed the study consent form, a fact sheet with information about the study, and the cbcl to complete before they bring their child to their appointment. mount sinai records from the birth hospitalization will be reviewed for the birth history and medical comorbidities. mount sinai medical records of the mother's obstetric care will also be accessed to obtain medical history from the pregnancy. if a participating child has received outpatient care at mount sinai, the investigators will access their record in epic to obtain scores from previous developmental assessments and records of medical comorbidities. if they have not attended the mount sinai clinic, but have received outpatient care elsewhere, the parents will be asked to provide contact information for their pediatrician, and for permission to obtain their child's records.

Eligibility criteria:
inclusion criteria: * born on or after january 1, 2011 * admitted to the mount sinai hospital for newborn care exclusion criteria: * non-english speaking

Keywords: development assessments premature birth
contributing factors to local bioimpedance spectroscopy

Conditions: Fluid and Electrolyte Imbalance; Overhydration; Edema

Summary: this is an exploratory interventional study. the aim of the investigation is to identify and quantify contributing factors to local bioimpedance spectroscopy (bis) measured by a wearable sensor patch, particularly the effect of fluid shifts caused by postural changes and lower body negative pressure (lbnp).

the investigational devices (patches) will perform near-continuous measurements of multifrequency bioimpedance (bis), temperature, and body orientation (accelerometer) during the entire period of wear (2 days). patches will be mounted at the upper body (back and thorax) and calf. the primary objective is to assess the effect of prolonged lower body negative pressure (lbnp) on the bis of the calf. the target population is healthy volunteers between 18-50 years old.

Eligibility criteria:
inclusion criteria: * 18 to 50 years of age, at the time of signing the informed consent * overtly healthy as determined by medical evaluation including medical history, physical examination and focused cardiac ultrasound. * use of adequate birth control for women of childbearing potential. inclusion is possible when an acceptable effective contraceptive measure is used (combined (estrogen and progestogen containing) hormonal contraception, progestogen-only hormonal contraception associated with inhibition of ovulation, intrauterine device, intrauterine hormone-releasing system, bilateral tubal occlusion, vasectomised partner or sexual abstinence). * capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (icf) and in this protocol. exclusion criteria: * known allergies or skin sensitivities to electrode hydrogel and/or acrylic adhesives * breached skin at patch mounting area. * implantable pulse generators such as pacemakers and defibrillators, and/or use of other electrical medical equipment for which an interaction effect with the investigational device cannot be ruled out. * planned magnetic resonance (mr) imaging during the investigation period * any medical condition limiting physical exertional capacity or requiring regular medication (allergy and contraceptives excepted). * pregnancy * breastfeeding * history of syncope (syncope of presumed vasovagal nature with known precipitating factor excepted). * any known cardiac disease that, at the investigator's discretion, warrants exclusion from the study, including but not limited to cardiac arrhythmia, esophageal varices, and aneurysms.

Keywords: hydration
proprioceptive training vs. hip abductor with external rotator strengthening in patients with patellofemoral pain

Conditions: Patellofemoral Pain Syndrome

Summary: patellofemoral pain syndrome (pfps) is a common musculoskeletal disorder characterized by an insidious onset of pain in the knee's anterior /retro-patellar / peripatellar region. even though various rehabilitation approaches, including hip strengthening and proprioceptive training, are being considered for managing pfps, the most appropriate treatment from these two is still unclear. therefore, this study aimed to compare the program consisting of hip abductors and external rotators strengthening exercises vs. the program consisting of proprioceptive training of the knee to identify the most effective rehabilitation approach for patients suffering from pfps.


Eligibility criteria:
inclusion criteria: * age 18-35 years * patients diagnosed recently by an orthopedic surgeon for patello-femoral pain syndrome * experiencing anterior/retro patellar knee pain during activities, * insidious onset of symptoms not linked to trauma, * pain persisting for no less than four weeks, * pain on palpation of the patellar facets, * pain when stepping down from a 25-cm step or during a double-legged squat. exclusion criteria: * patients with recent lower limb fractures or dislocations, * knee/hip joint surgery, * signs, symptoms, or radiological findings of intra-articular pathology such as effusion, ligamentous or meniscal involvement, * those with indications of patellar apprehension, * referred pain from the hip, back, or sacroiliac joint, * acute knee strain or sprain, * on medication such as nsaids or corticosteroids, * degenerative and infectious arthritis

Keywords: hip muscles strengthening rehabilitation proprioceptive training exercises
the genotype and phenotype of lymphangioleiomyomatosis

Conditions: Sporadic Lymphangioleiomyomatosis; TSC-associated Lymphangioleiomyomatosis

Summary: this study aims to differentiate between sporadic lymphangioleiomyomatosis and tuberous sclerosis complex-associated lymphangioleiomyomatosis.


Eligibility criteria:
inclusion criteria: * age ≥ 18 y/o * patient with chest ct showed cystic lung disease, suspected lymphangioleiomyomatosis exclusion criteria: * age \< 18 y/o

Keywords: lymphangioleiomyomatosis
the sequence of fixation in tile c1.2 and c1.3 vertical shear pelvic ring injuries.

Conditions: Pelvic Ring Fractures; Pelvic Ring Injury

Summary: the goal of this study is to compare the sequence of fixation in vertically unstable tile c1.2 and c1.3 pelvic ring injuries, as regards clinical, radiological outcomes and implant failure rates. our hypothesis is that starting with anterior ring fixation will achieve superior results as regards easier reduction, less operation time, and finally better radiological and functional outcomes when compared with starting with posterior ring fixation.


Eligibility criteria:
inclusion criteria: 1. age: 18 years - 60 years. 2. tile c1.2 and c1.3 pelvic ring injuries. 3. pure anterior ring ligamentous injuries. exclusion criteria: 1. bony fracture of the pubic rami. 2. tile c2 and c3 pelvic ring injuries. 3. associated acetabular fracture that requires intervention.

Keywords: pelvic ring injuries vertical shear pelvic fracture tile classification