Kornimate/medical-research-clean huggingface dataset:
efficacy of curcumin in oral submucous fibrosis

Conditions: Oral Submucous Fibrosis

Summary: the purpose of the study is to determine whether the formulations of curcumin will effect the clinical signs and symptoms and histopathological features in patients with clinical stage 2 oral submucous fibrosis (osmf).

200 clinical stage 2 osmf patients selected randomly by simple random technique with clinically \& histopathologically confirmed diagnosis are divided into 4 groups with 50 patients each. in group 1 patients are given 10% of curcumin mucoadhesive gel and are instructed to use it topically twice daily making it a daily dose of 1gm. in group 2 patients are given 500mg of curcumin capsules and are instructed to take 2 capsules twice daily making a daily dose of 1gm. in group 3 patients will be given 5% of curcumin mucoadhesive gel and will be instructed to use it topically twice daily \& 250mg of curcumin capsules to be taken twice daily making it a daily dose of 1gm. group 4 is considered as control group and provided with formulations without the active drug. the mean scores of 4 groups will be statistically tested using anova technique. the differences in clinical parameters at 15 days, 1 month, 3 months \& clinical \& histopathological paramerters at 6 months will be compared between groups 1, 2, 3 \& 4 by using students 't' test \& correlation is also used for knowing the association of variables. for all tests, a 'p' value of 0.05 or less will be utilized for statistical significance. other non parametric tests can also be applied where ever necessary for data analysis.

Eligibility criteria:
inclusion criteria: * 200 clinical stage 2 osmf patients exclusion criteria: * clinical stage 1 \& 3 osmf patients, oromucosal disorders with clinical features same as osmf, patients who are under treatment, clinically diagnosed cases not ready for incisional biopsy, patients suffering from medically compromised conditions.

Keywords: oral submucous fibrosis curcumin potentially malignant disease
glucagon-like peptide-1 levels, insulin resistance and insulin sensitivity index in type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus; PreDiabetes

Summary: this study is conducted to examine glp-1, insulin resistance and insulin sensitivity portfolio in malay, chinese and indian populations in malaysia and to study the effect of dppiv inhibitor in t2dm patients with different glp-levels.


Eligibility criteria:
inclusion criteria: * subjects are newly diagnosed of t2dm according to world health organisation criteria) and do not receive any glucose-lowering drugs * subjects with normal glucose tolerance test according to world health organisation criteria which is carried out immediately before inclusion in the study * subjects who are willing to participate and sign the informed consent form exclusion criteria: * patients with pre-existing t2dm * patients with family history of diabetes * patients receiving glucose-lowering medications * patients with anemia, abnormal serum creatinine level, macroalbuminuria, proliferative retinopathy, impaired liver function
early vs. late referral for scapular exercises in shoulder function after neck dissection

Conditions: Rehabilitation

Summary: this study aims to investigate the effects of comparing early versus late referrals for scapular-focused exercise on shoulder function in head and neck cancer patients following neck dissection.

this study will recruit 30 head and neck cancer patients with spinal accessory nerve shoulder dysfunction based on the timing of referral, which will be divided into early (within 2 months post-surgery) and late (after 2 months post-surgery) referral groups. both groups will receive conventional physical therapy (e.g., shoulder joint mobility training, electrical stimulation, or laser therapy for pain relief) and scapular-focused exercises. scapular-focused exercise primarily targets the trapezius muscle, 60 minutes each session, once a week for 12 weeks.

Eligibility criteria:
inclusion criteria 1. age between 20 and 65 years. 2. newly diagnosed with head and neck cancer and experiencing clinical symptoms of accessory nerve dysfunction after unilateral neck dissection, such as shoulder drooping, restricted active range of motion in shoulder abduction, or insufficient muscle strength against gravity in shoulder abduction. 3. scapular dyskinesia, such as asymmetrical scapular movement in multiple planes. 4. scapular asymmetry, defined as a bilateral difference of more than 1.5 cm between the inferior angle of the scapula and the spinous process of the seventh thoracic vertebra when performing 90° shoulder abduction in the scapular plane under a 1 kg load. exclusion criteria： 1. presence of distant metastasis or cancer recurrence. 2. inability to communicate or comprehend the questionnaire. 3. history of shoulder pain within one year before neck dissection. 4. any condition that may affect motor performance. 5. history of neuromuscular disorders or tendon pathology in the affected shoulder, other than accessory nerve dysfunction.

Keywords: shoulder exercise head and neck cancer
intra-articular platelet rich plasma vs corticosteroid in treatment of knee osteoarthritis patients

Conditions: Osteoarthritis Knee; Corticosteroid; Platelet Rich Plasma

Summary: knee osteoarthritis is the most common type of osteoarthritis in the lower extremity and constitutes 23% of all arthritis cases, about 13% of females and 10% of males aged above 60 years have symptomatic knee oa. intra-articular corticosteroids (iacs) are a frequently-used treatment regimen for pain relief from symptomatic knee oa as it inhibits inflammation and reduces prostaglandin synthesis. platelet-rich plasma (prp) is an autologous blood product containing a high percentage of various growth factors (gfs), such as fibroblast growth factor, epidermal growth factor, vascular endothelial growth factor, transforming growth factor-β and platelet-derived growth factor. the aim of this study is to compare effect of intra-articular injection of platelet rich plasma versus corticosteroid in treatment of primary knee osteoarthritis.


Eligibility criteria:
inclusion criteria: * patients 40-70 years of age suffering from knee oa with kellgren lawrence grade ii or iii on standing antero-posterior and lateral knee radiographs. * patients diagnosed according to acr classification criteria. exclusion criteria: * systemic diseases as patients having diabetes mellitus,cardiovascular diseases or coagulopathies. * those receiving treatment with anticoagulant , anti_platelet medications or systemic corticosteroid 10 days before injection or recent use of nsaids. * pregnant and breast feeding females. * patients have hemoglobin values \<10 g/dl or platelet values\<150,000/ml.
the role of incretins in bone remodeling in humans

Conditions: Incretins; Osteoporosis; Bone Remodeling; Healthy

Summary: the role of incretins (gip and glp-1) on cells and bone tissue has been shown in cellular and animal studies. in humans, the role of these hormones is mainly studied in the pathophysiology of diabetes, their effect on bone is unknown. the serum incretin concentration is low and increases rapidly after a meal. this increase is brief, incretins being rapidly degraded by dipeptidylpeptidase 4 (dpp-4). the dosage of these hormones is complex and the basal "normal" serum concentrations and after feeding in healthy subjects are unknown. before any study on the effect of incretins on bone remodeling in humans, it is necessary to establish physiological concentrations of incretins in healthy subjects. the aim of this study is to estimate physiological concentrations of incretins in healthy subject.


Eligibility criteria:
inclusion criteria: * healthy women and men exclusion criteria: * known osteoporosis * osteoporotic fracture * tobacco * alcohol : \> 2 glasses/day * type 1 and type 2 diabetes * bmi \ 30kg/m² * heart failure, kidney failure * cancer * bariatric surgery * graft * cirrhosis * use in the past year : bisphosphonate, denosumab, raloxifene, teriparatide, oral or iv glucocorticoid during 3 months or more
relationship between lrg and periodontal disease

Conditions: Periodontitis; Acute-Phase Response; Inflammation

Summary: this study aimed to investigate gingival crevicular fluid (gcf) and serum levels of lrg, interleukin (il)-6 and tumor necrosis factor (tnf)-α in patients with periodontitis before and after non-surgical periodontal treatment.

twenty-five stage 3 periodontitis and twenty-five periodontally healthy individuals were enrolled in the study. clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and gcf and serum samples were obtained at baseline and at 6 weeks after treatment. lrg, il-6 and tnf-α were determined by elisa.

Eligibility criteria:
inclusion criteria: 1. 25-50 years of age 2. having at least 20 natural teeth, excluding third molars 3. having no systemic disease 4. non-smokers 5. criteria for healthy control group: bop \< 10% and pd ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction 6. criteria for stage 3 periodontitis group: interdental cal ≥ 5 mm at least 2 non-adjacent teeth, pd ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond. exclusion criteria: 1. having any systemic diseases, 2. smoking 3. current pregnancy or lactation 4. a history of periodontal treatment in the past 6 months 5. using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

Keywords: periodontitis gingival crevicular fluid serum
effect of umbilical cord milking on iron related health outcomes for cesarean-delivered infants

Conditions: Anemia, Iron-Deficiency

Summary: this study aims to determine whether umbilical cord milking can improve iron related health outcomes for cesarean-delivered infants. half of participants will receive umbilical cord milking, while the other half will receive routine clinical treatment and care.

in recent years, several professional organizations have recommended delayed cord clamping to improve placental transfusion for newborns born vaginally based on a series of randomized controlled studies. however, no similar recommendations are available for cesarean-delivered infants. investigators found that cesarean-delivered infants were more vulnerable to iron deficiency and anemia compared with those born vaginally, suggesting that it is urgently needed to find a similar anemia prevention strategy for infants born by cesarean sections. in this study, investigators aim to test whether umbilical cord milking (ucm), a potentially promising strategy for cesarean delivery, can improve iron related health outcomes for cesarean-delivered infants. a total of 450 term pregnant women who are planning to give births by cesarean sections will be enrolled from two hospitals in hunan province and randomly assigned to either ucm group or control group. infants will be followed up at 1, 6, 12, 18 months for the evaluation of the impact of ucm on iron deficiency, anemia, as well as growth and the developmental status of language and mental/behavioral outcomes.

Eligibility criteria:
inclusion criteria: * singleton pregnancy * full-term pregnancy (no less than 37 gestational weeks) * cesarean section before the labor starts or cesarean section after the labor starts but with cervix less than 3 cm * plan to take vaccines and receive routine child health care in the hospital where she gives birth exclusion criteria: * maternal hypertensive disorder * gestational diabetes with macrosomia * gestational diabetes with polyhydramnios * maternal severe anemia with hemoglobin less than 70 g/l * maternal coagulation disorders * fetal growth restriction * major congenital anomalies * hemolytic disease of the newborn or hydrops fetalis * short umbilical cord length (\< 30 cm) * severe cord or placenta abnormalities such as cord prolapse, true knots, placental abruption and placenta previa * other conditions that are not suitable for the study judged by the doctors

Keywords: anemia, iron-deficiency cesarean section umbilical cord milking randomized controlled trial
a comparison of morphine and morphine plus dexmedetomidine in chronic cancer pain

Conditions: Chronic Pain

Summary: the purpose of this study is to determine whether dexmedetomidine added to morphine is effective in the treatment of chronic cancer pain.

we conduct the study in cukurova university faculty of medicine research hospital after obtaining ethics committee approval and patient's informed consent. patients with cancer pain are allocated into two group to receive patient controlled analgesia with morphine or morphine plus dexmedetomidine.

Eligibility criteria:
inclusion criteria: * patients with chronic cancer pain * between 20-80 years old age exclusion criteria: * the presence of severe systemic disease(cardiac, pulmonary, hepatic or renal) * psychiatric or neurologic disease * unable to communicate verbally * nausea and vomiting * patient's refusal

Keywords: chronic pain morphine dexmedetomidine
management of advanced non-small cell lung cancer (nsclc) and clinical outcomes in patients who received gefitinib in thailand

Conditions: Lung Cancer

Summary: the purpose of this study is to determine progression-free survival of lung cancer patients who received gefitinib in clinical practice in thailand.


Eligibility criteria:
inclusion criteria: * diagnosed as having lung cancer based on histological/cytological findings * admitted to the hospital between january 2004 and december 2008 * treated with gefitinib for at least 3 months exclusion criteria: * involvement in the planning and/or conduct of the study * participation in another clinical study during the last 3 months

Keywords: advanced nsclc gefitinib thai patient
hemorl: monocentric, prospective, comparative study on the use of a haemostatic vacuum device during tonsillectomy in children

Conditions: Tonsillectomy; Hemorrhage; Postoperative Complications

Summary: the long-term objective of this study is to prove: * the equivalence of the number of post-operation hemorrhages, and maybe a decrease of the number of secondary hemorrhages * the decrease of pain and quicker re-feeding * an easier haemostasis * the simplification of the tonsillectomy surgical kit * the decrease of dissection time


Eligibility criteria:
inclusion criteria: * children from 3 to 10 years old undergoing tonsillectomy (with or without adenoidectomy) * children without known hemophilia or any coagulation trouble * children speaking and understanding french * children's both parents must speak and understand french * children's both parents must be affiliate to social security or similarly regime exclusion criteria: * children with known allergy to silicone * refusal to consent: from child's age to consent or from both parents * telephone monitoring refusal * protected person referred to in articles l1121-6 of the code of public health * children's both parents are protected persons referred to in articles l1121-8 of the code of public health

Keywords: tonsillectomy children vacuum medical device pain hemorrhage post-surgical complications
nutritional assessment tool in childhood chronic liver disease

Conditions: Chronic Liver Disease

Summary: study cohort: all children (age: 3 months- 18 years, corrected age upto 2 years for preterm children) with chronic liver disease attending pediatric hepatology out patient department/in patient department


Eligibility criteria:
inclusion criteria: 1. children from age of 3 months- 18 years (corrected age upto 2 years for preterm children) 2. chronic liver disease. exclusion criteria: 1. any metabolic or endocrinal diseases independently affecting nutritional status 2. refusal to give written informed consent to participate in the study
high resolution ultrasound in pancreatic ductal adenocarcinoma

Conditions: Pancreatic Ductal Adenocarcinoma

Summary: pancreatic cancer patients at uhn who have had a ct at uhn and have surgery planned will undergo a high resolution ultrasound pre-operatively and intra-operatively. this study is being done to see if using high resolution ultrasound before and during surgery will help the doctors accurately diagnose pancreatic ductal adenocarcinoma and identify if the disease has spread to other areas of the body.


Eligibility criteria:
inclusion criteria: 1. males and females \> 18 y 2. pdac diagnosed by typical imaging findings or pathology 3. scheduled for surgical resection 4. contrast enhanced ct scan performed locally at uhn exclusion criteria: 1) inability or unwillingness to provide informed consent
the impact of anxiety or depression on the sedative concentration of propofol

Conditions: Anxiety; Depression; Propofol; Anesthetics, Intravenous

Summary: 120 consecutive female patients, 18-65 years old, american society of anesthesiologists (asa) physical status i to ii, scheduled for hysteroscopic surgery under propofol-based intravenous anesthesia will be recruited in this cohort study. the day before surgery, participants will be assessed the state of preoperative anxiety and depression. on the day of surgery, propofol will be administered by target controlled infusion (tci) pump. during induction of anesthesia, the level of sedation will be evaluated. the induction dose of propofol, target effect-site concentration(cet), plasma concentration(cp) and effect-site concentration (ce) of propofol will be recorded.

120 consecutive female patients, 18-65 years old, american society of anesthesiologists ( asa) physical status i to ii, scheduled for hysteroscopic surgery under propofol-based intravenous anesthesia will be recruited in this prospective cohort study. the day before surgery, participants were asked to complete the modified hads questionnaire in an isolated calm room, and the score was used to assess the patients' anxiety and depression level in the past 6 months. on the day of surgery, propofol (fresenius kabi austria gmbh, graz, austria)was administrated by using an intravenous target controlled infusion (tci) pump (alaris pk, basingstoke, uk) with schnider kinetic model. the initial effect-site concentration (ce) was set as 1.0 μg/ml. after the tci system displayed that cp and ce were at equilibrium, the target concentration of propofol was increased by an increment of 0.5 μg/ml until the patients achieved the three desired levels of sedation.the ce and dose of propofol and the consuming time were recorded.

Eligibility criteria:
inclusion criteria: * female * american society of anesthesiologists（asa） physical status i or ii * body mass index(bmi) 18-25kg/m2 * scheduled for hysteroscopic surgery under propofol-based intravenous anesthesia. exclusion criteria: * suffering from psychiatric diseases. * chronic use of anxiolytics, antidepressants, and sedative-hypnotics. * any sedative premedication. * a history of alcohol abuse. * allergy to propofol. * declining to participate and cooperate.

Keywords: female prospective studies anesthetics, intravenous propofol anxiety/*psychology depression/*psychology
freder1k-study - testing infants for type 1 diabetes risk

Conditions: Identification of Infants at Risk for Type 1 Diabetes

Summary: the freder1k-study will identify infants who have a high genetic risk of type 1 diabetes.

type 1 diabetes is a common chronic disease in childhood and is increasing in incidence. type 1 diabetes is diagnosed by hyperglycemia often in combination with symptoms of weight loss, thirst, fatigue and frequent urination, sometimes with ketoacidosis. the clinical onset is preceded by an asymptomatic phase identified by serum multiple beta-cell autoantibodies. neonates and infants who are at increased risk to develop multiple beta-cell autoantibodies and type 1 diabetes can now be identified using genetic markers. this provides opportunity for introducing early therapies to prevent beta-cell autoimmunity and type 1 diabetes.

Eligibility criteria:
inclusion criteria: * age: up to age 6 weeks * provided written informed consent by custodial parent exclusion criteria: -

Keywords: infants type 1 diabetes freder1k
predictive factors for hypotensive bradycardic events during arthroscopic shoulder surgery

Conditions: Syncope, Vasovagal

Summary: patients's demographics and perioperative factors affect the occurrence of hypotensive bradycardic events in the patients undergoing arthroscopic shoulder surgery in the sitting position under interscalene block.

patients' age, side of the block,horner's syndrome, the degree of blockade, preoperative fasting time and fluid administration volume, waiting time for sitting position after the block, intraoperative use of opioids and antihypertensives, and change of heart rate variability before the block and after sitting position affect the occurrence of hypotensive bradycardic events in the patients undergoing arthroscopic shoulder surgery in the sitting position under interscalene block.

Eligibility criteria:
inclusion criteria: * age between 15 and 80 years * american society of anesthesiologists physical status i-ii * body mass index \< 35 kg/m2 exclusion criteria: * coagulation deficiencies * known allergies to local anesthetics * neurologic deficit on the side to be operated * inflammation at the puncture site for interscalene brachial plexus block * coronary artery disease * cardiac conduction disorders and arrhythmias * congestive heart disease * diabetes mellitus * serum electrolyte abnormalities * autonomic dysfunction * psychiatric disorders * patients refusal * communications difficulties * failure of interscalene brachial plexus block

Keywords: hypotensive bradycardic event interscalene brachial plexus block sitting position shoulder arthroscopic surgery
development of systems and precision medicine - take mood disorder as an example.

Conditions: Mood Disorders

Summary: precision medicine is to achieve individual optimal health care, given the biological mechanisms, genetic variants, and environmental measurements. take mood disorder (md) as an example, we aim to develop systems and precision medicine in taiwanese population. md is a very serious and dysfunctional mental disorder. since md patients with treatment have high risk of neurocognitive impairment and metabolic disturbances, the therapeutic strategies are of clinical importance. individual difference of treatment outcome in md patients would result from genetic variants, environmental factors, and their interactions. also, the treatment outcome of md contains multiple dimensions, including improvement of disease severity, neurocognitive function, and optimized medication strategy. however, comprehensive development of approaches to investigate the multiple dimensions of treatment outcome in md patients is limited. in this three-year proposal, we explore the interactions of genetic variants and environmental factors (represented by psychosocial stress and gut microbiota) driven approaches to develop precision medicine.


Eligibility criteria:
inclusion criteria: * male or female patients, 20- 70 years of age * major depression disorder who met the dsm-v diagnostic criteria were enrolled * subjects take at least one kind of antidepressant. exclusion criteria: * pregnant or breast-feeding * presence of any other major psychiatric illness * history of substance and alcohol abuse or dependence * presence of auto-immune disorder and infectious diseases

Keywords: mood disorder, neurocognitive function, metabolic disturbances, microbiota-gut-brain axis, genetic variant, pharmacogenomics