Kornimate/medical-research-clean huggingface dataset:
hydration based on thoitaine, aloe vera and calendula, in the prevention of hand-foot syndrome in patients using capecitabine

Conditions: Hand-foot Syndrome

Summary: hand-foot syndrome (hfs) is a very common adverse event of many chemotherapeutic agents, especially capecitabine. the hfs can considerably interfere patient quality of life (qol). the current treatments for hand-foot symptoms no have demonstrated 100% efficacy. and, the dose reduction and treatment interruption are recommended for treatment of hfs. it is known that hydration improves the degree of hand-foot syndrome, as it improves moisture retention and maintain hydration, thereby reducing further desquamation and decreasing infection risks. but so far there is no evidence of a cream that improves incidence. besides that, clinical trials evaluating the use of urea-based moisturizer in patients treated with capecitabine have not shown efficacy in preventing hand-foot syndrome. the purpose of this study is to evaluate the effectiveness of moisturizer based on thoitaine, aloe vera and calendula compared to placebo in the prevention of smp of any degree, in patients using capecitabine.

the research product, proposed in this study, was developed to meet the specific hydration needs of patients undergoing cancer treatment and is produced from nine main ingredients with natural moisturizing actions based on glycerin, hazelnut extract, shea butter, aloe vera, calendula, chamomile and oat extract and 2 antioxidants (vitamin e and thoitaine), dermatologically tested and approved. the choice of the product was based, mainly, due to its natural components, whose data from previous studies were extrapolated from radiodermatitis.

Eligibility criteria:
inclusion criteria: * male or female ≥18 years of age * patients with gastrointestinal tumors or breast cancer who will be treated with capecitabine * indication of adjuvant or palliative treatment with capecitabine * eastern cooperative oncology group (ecog) 0-2 * information of the patient and signature of the informed consent form by the patient or her legal representative. exclusion criteria: * previous chemotherapy with capecitabine * pre-existing patients with neuropathies * patients with known allergic reactions to any of the ingredients of the investigational product * patients with dermatological conditions that affect the hands or feet * patients with rectal neoplasia and indication for neoadjuvant treatment.

Keywords: hand-foot syndrome palmoplantar erythrodysesthesia acral erythema capecitabine moisturizing cream
neuralized1 and rgs14 genes

Conditions: Autism Spectrum Disorder; High-functioning Autism; Healthy

Summary: autism is a broad spectrum neurodevelopmental disease. some individuals with ads by high cognitive functions are diagnosed with high functioning autism (hfa). in some studies, it has been shown that neurl1 gene increases learning and memory and rgs14 gene is suppressed them. we aimed to evaluate the differences between the expression levels of these genes between asd, hfa and healthy controls and the role of these genes in the pathogenesis of asd. patients with 20 asd and 20 hfa, and 20 healthy controls compatible with patient ages were included in this study. expression of neurl-1 and rgs14 genes was evaluated by quantitative real time pcr (qrt-pcr).

asd is a neurological disease starting in the early stages of life and is characterized by cognitive and behavioral disorders (ansel et al., 2008;alvares et al., 2020). it is considered that the etiology of asd stems from genetic, epigenetic and environmental factors; however, it has not yet been definitively clarified(ito et al., 2017). we aimed to evaluate the differences between the expression levels of these genes between asd, hfa and healthy controls and the role of these genes in the pathogenesis of asd. method: patients with asd (n=20) and hfa (n=20), and healthy controls (n=20) compatible with patient ages were included in this study. clinical evaluations of the patients were made and classification was made in accordance with dsm-iv diagnostic criteria. high pure rna isolation kit (roche diagnostic, version 12, germany) was used for rna isolation. cdna synthesis was performed from these rnas with the ranscriptor high fidelity cdna synthesis kit (roche diagnostics, gmbh, mannheim). qrt-pcr was performed using the lightcycler®480 real time ready assay master probe kit (roche diagnostics, gmbh, mannheim).the incubation was made with the pcr device program for 10 minutes at 95oc for 45 cycles, for 10 sec at 95oc, and for 60 sec at 60oc. the ct values were obtained from the light cycler 480 software program, and both genes were analyzed separately. the comparative ct method (2-δδct) was used to determine the relative quantification of target genes, normalized to a housekeeping gene (β-actin). statisticaly: the results of the experiments were evaluated using r 3.1.1 (www.r-project.org). and chi-square tests, mann-whitney u-test, kruskal-wallis h-tests. the p\<0.05 level was taken as significant.

Eligibility criteria:
inclusion criteria: * being diagnosed asd or hfa patient, * being between the ages of 2-16. exclusion criteria: * to use medicine, * have a other syndromic illness, * being younger than 2 years old or over 16 years old.

Keywords: asd high functioning autism neurl1 rgs14 gene expression
study of microbiological diversity in exhaled air in copd and free of copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: copd and non-copd patients will be included in the study after collection of their non-objection. the exhalation will be collected to study the microbiological diversity of human exhalations. a second collection for the year +1 will be made, at the same time (between october and march).

the subjects will be recruited during a medical visit in the departments of pneumology and occupational and environmental pathologies. after information and inclusion of the subject in the study, a collection of clinical data, the state of health and the smoking status of the subject will be carried out by the clinical study technician. a collection of the exhalation will also be carried out by the clinical study technician. several groups of subjects will be formed according to pathologies (copd versus non-copd), age and smoking status

Eligibility criteria:
inclusion criteria: for copd: * patients with chronic obstructive pulmonary disease * age: over 18 for non-copd * absence of chronic obstructive pulmonary disease * age: between 18 and 30 years old and between 45 and 70 years old exclusion criteria: * taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants) * person under guardianship or curatorship * pregnant or breastfeeding women * person unable to express his/her opposition, person deprived of liberty * existence of a chronic infectious pulmonary pathology such as (dilation of the bronchi, cystic fibrosis)
management of anal fistula of crohn disease

Conditions: Anal Fistula; Crohn Disease

Summary: the management of anal fistula in crohn disease is complex. in aim to obtain the healing of the anal fistula, different approaches can be proposed but the best strategy is not yet determined. the aim was to describe the therapeutic management of anal fistula in crohn disease.

patients with anal fistula with crohn disease and needed anal fistula drainage will be included. medical and surgical treatments will be recorded. the management will be described and the best approaches will be identified.

Eligibility criteria:
inclusion criteria: * patient over 18 years of age * crohn's disease with fistulizing anoperineal lesion * operated at least once for this reason exclusion criteria: * adult person protected under the public health code * minor person

Keywords: crohn disease anal fistula anal surgery
study of the breast milk microbiota and its influence on the development of early and late neonatal bacterial sepsis under three months of age.

Conditions: Neonatal Sepsis

Summary: breast milk contains many microorganisms including bacteria that are beneficial to health (probiotics), but also bacteria that are generally considered pathogenic. several studies have described an increased risk of infections due to pathogenic germs in breast milk in premature newborns whose digestive system is immature and whose digestive flora is modified by repeated antibiotic treatments. however, a breastfed baby is better protected against infectious diseases than a bottle-fed baby. the objective of this study is to define the breast milk microbiota of infants with confirmed early or late neonatal bacterial infection compared to the breast milk microbiota of infants with no evidence of bacterial infection. for that purpose, an exploration will be performed using the principle of "microbial culturomics" and targeted metagenomics (16s ribosomal rna gene sequencing).


Eligibility criteria:
inclusion criteria: breastfeeding mothers of infants: * aged 1 to 89 days consulting in hospitals in the marseille area (assistance publique des hôpitaux de marseille: hôpital de la timone-enfants and hôpital nord), * suspected neonatal bacterial infection due to the presence of fever (rectal or axillary temperature \> 38°c), * in whom bacteriological samples have been taken (cerebrospinal fluid, joint fluid, blood cultures, urine), * patients affiliated or benefiting from a social security system. exclusion criteria: * exclusive formula milk feeding * opposition of legal guardians * no bacteriological sample to prove infant infection * no confirmation of fever by standardized method * opposition to participating in the study * neonatal hospitalization \> 48 hours for management of prematurity. * severe congenital malformations in the infant. * antibiotic treatment for a concomitant bacterial infection in the infant.
usefulness of calprotectin for colon adenoma screening

Conditions: Colon Adenoma

Summary: the fecal calprotectin assay is used widely for inflammatory bowel disease diagnosis and the assessment of the disease activity. some adenoma patients have elevated fecal calprotectin level, which could mean the role of fecal calprotectin as a screening marker for colon adenoma. we will investigate the usefulness of fecal calprotectin as colon adenoma marker for screening in this study.


Eligibility criteria:
inclusion criteria: * over 18 years old adult population exclusion criteria: * none

Keywords: adenoma calprotectin
study of nvn1000 topical gel and topical gel vehicle in the treatment of moderate to severe acne vulgaris

Conditions: Acne Vulgaris; Acne

Summary: the primary objective of this study is to compare the tolerability, safety and efficacy of nvn1000 topical gel and topical gel vehicle in the treatment of subjects with moderate to severe acne vulgaris.

the objective of this study is to evaluate the tolerability, safety and efficacy of once daily application of nvn1000 topical gel for 8 weeks in comparison with its vehicle in subjects with moderate to severe acne.

Eligibility criteria:
inclusion criteria: * baseline iga score of moderate (3) or severe (4) * minimum of 20 but no more than 40 facial inflammatory lesions * minimum of 20 but not more than 60 facial non-inflammatory lesions * no more than 2 facial nodules exclusion criteria: * dermatological conditions on the face that could interfere with clinical evaluations * underlying disease(s) or some other dermatological condition of the face that requires the use of interfering topical or systemic therapy or makes evaluations and lesion count inconclusive * history of experiencing significant burning or stinging when applying any facial treatment * female subjects, if they are pregnant,nursing mothers, or planning to become pregnant during the study * have used estrogens or oral contraceptives for less than 90 days immediately preceding the baseline visit, discontinued use of estrogens or oral contraceptives less than 90 days prior to baseline,or planning to begin or discontinue use of this therapy during the treatment period * have used medications and/or vitamins which are reported to exacerbate acne during the 180 days immediately preceding the baseline visit * use concomitantly over-the-counter (otc) products that contain ingredients such as benzoyl peroxide,salicylic acid,alpha-hydroxy acid,retinol or glycolic acids * have not undergone the specified washouts for topical preparations,systemic medications and procedures noted in the protocol

Keywords: acne vulgaris acne
impact of neurological diseases on the prognosis of bullous pemphigoid: a retrospective study of 178 patients

Conditions: Bullous Pemphigoid

Summary: bullous pemphigoid affects mainly elderly patients. it is often associated with neurologic disorders, which represent a major risk factor of the disease

the aim was to determine whether neurologic disorders, especially dementia, influences outcome and mortality of patients with bullous pemphigoid.

Eligibility criteria:
inclusion criteria: * patients presenting bullous pemphigoid using the following criteria: clinical features typical of bp with presence of at least three out of four well-established criteria of vaillant et al., subepidermal blister on skin biopsy and deposits of igg and/or c3 in a linear pattern along the epidermal basement membrane zone by direct if * patients consulting at dermatology department of reims teaching hospital (france) between 1997 and 2011

Keywords: bullous pemphigoid neurologic disorders
alternating dbs for stepping control in parkinson's disease

Conditions: Parkinson Disease

Summary: parkinson's disease (pd) is a disabling, progressive condition characterised by severe problems with movement for which medical treatment in the longer term can be unsatisfactory. deep brain stimulation (dbs) is a treatment, which directly stimulates the nerve cells affected inside the brain to help overcome the difficulties with movement. classically, dbs stimulates in a manner that is constant. many patients develop severe problems with walking, so-called freezing of gait, which can be unresponsive to constant dbs. in this study the investigators will test if left-right alternating dbs helps to improve gait problems by potentially promoting left-right alternating up- and down-modulated brain activity, which was found during walking in a previous study. the investigators will test if alternating dbs improves the ability to adjust walking speed and to walk freely compared to constant dbs.


Eligibility criteria:
inclusion criteria: * pd patients with bilateral subthalamic nucleus dbs electrodes and stimulators implanted for at least 6 months * able to give consent. exclusion criteria: * lack of capacity to consent * cognitive impairment/lack of capacity to perform experimental task. the investigators will additionally conduct a short (10 min) quantitative assessment of cognitive function using a validated test (mmse). patients with a score \< 20 will be excluded from the study.
effects of training of pelvic floor muscles (map) on stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: in the current scientific literature, it is clear that sui can cause several social, hygienic and personal relationship problems. it has also been proven that this condition affects many more menopausal women than menacme, and this is believed to be due to the hypoestrogenism characteristic of this phase. on the other hand, weakness of the pelvic floor muscles (pfm) is also related to the genesis of sui. the role of these muscles would be to keep the bladder neck elevated (above the pubic symphysis) during increases in abdominal pressure, and its weakness would lead to excessive lowering of the bladder neck at these times, leading to sui due to bladder neck hypermobility. the conservative treatment of this condition, therefore, encompasses the strengthening of pfms, which would avoid excessive descent of the bladder neck during increases in abdominal pressure, thereby reducing urinary loss. in the current literature there are studies proving the effectiveness of pelvic floor muscle training; however, in relation to the literature on abdominal hipopressive gymnastics, it is observed that the scientific evidence is still poor, however, the technique is still widely spread through extension courses offered throughout latin america, france and spain; with regard to the comparison of these methods with respect to their clinical efficacy and the quality of life and patient satisfaction, there are no consistent studies, and this fact motivated us to carry out this study.


Eligibility criteria:
inclusion criteria: * women with iue and with a modified oxford scale of at least 1. exclusion criteria: * presence of neuromuscular diseases * uncontrolled diabetes
sars-cov-2 detection from used surgical mask

Conditions: SARS-CoV-2 Virus

Summary: the real-time reverse transcription-polymerase chain reaction (rt-pcr) test is regarded as the gold standard for sars-cov-2 detection. proper specimen collection and obtaining a sufficient sample are the most important steps for laboratory diagnosis. the nasopharyngeal (np) swab is recommended as the reference collection method. however, np swab collection is invasive and uncomfortable for patients and poses some risk to healthcare workers. this study aimed to compare the efficacy of sars-cov-2 rna detection from used surgical masks with the np swab method using rt-pcr testing

proper specimen collection and obtaining sufficient samples are the most important steps for laboratory diagnosis of an infectious disease. improper collection may lead to false or inconclusive test results. during the early stages of the covid-19 outbreak, the center for disease prevention and control recommended collecting and testing an upper respiratory specimen \[4\]. nasopharyngeal (np) and oropharyngeal (op) swabs are the preferred choice for initial sars-cov-2 diagnostic testing. this study aimed to compare the efficacy of sars-cov-2 rna detection from used surgical masks with standard detection methods. we tested for sars-cov-2 rna in masks from patients with covid-19 that had been worn for eight hours and compared this with np swabs using rt-pcr testing. hospitalized patients with laboratory-confirmed covid-19 were recruited to provide surgical masks. collection of used surgical mask samples by patients themselves is easy, convenient, requires no sampling equipment and decreases the risk of healthcare personnel exposure to covid-19. if sars-cov-2 rna can be detected on used surgical mask samples, this may encourage patients to provide specimens for testing and help in early detection and transmission prevention. as an alternative method to np swabs, it may facilitate timely diagnosis and treatment.

Eligibility criteria:
inclusion criteria: * newly confirmed sars-cov-2 positive cases admitted to a field hospital within 48 hours or outpatient with a positive result for sars-cov-2 * should be able to wear a mask for 8 h according to the protocol exclusion criteria: * require oxygen intubation or any breathing support devices

Keywords: nasopharyngeal swab rt-pcr sars-cov-2 surgical mask
adjuvant post-radical cystectomy treatment for bladder cancer

Conditions: Locally Advanced Bladder Cancer

Summary: radical cystectomy is still the standard treatment in muscle-invasive bladder cancer. local recurrence is still the major cause of failure together with distant metastasis. postoperative radiotherapy succeeded to decrease the local recurrence and hence improved the overall survival. adjuvant chemotherapy has also improved the survival in different studies. this study is performed to test the efficacy and toxicity of adding the two modalities together compared to each modality alone.


Eligibility criteria:
inclusion criteria: * patients not more than 70 years old. * radical cystectomy performed within 42 days with no microscopic or macroscopic residual after surgery (negative surgical safety margins) * having one or more of the risk factors ( p3b,p4a,g3 and /or positive ln) * ecog performance scale (0-2). * adequate liver functions. * adequate renal function serum (creatinine \< 1.5 mg). * no evidence of distant metastasis or other malignancy. exclusion criteria: * patients who received radiotherapy or chemotherapy prior to radical cystectomy

Keywords: locally advanced bladder cancer postoperative radiotherapy adjuvant chemotherapy radical cystectomy
use of novel high-protein food products to reduce insulin resistance

Conditions: Insulin Resistance

Summary: this controlled weight loss trial in adults at cardiometabolic risk (elevated triglyceride/hdl ratio) followed a randomized, cross-over design and utilized novel, high-protein pasta and cereal to examine the physiological impact of stealth substitution of dietary carbohydrate with protein derived from soy concentrates, wheat protein isolates, and dried egg whites. pasta dishes were prepared using high-protein orzo and fusilli pasta (zone pastarxtm) or conventional, gluten-free pasta, and high-protein flaked cereal (zonetm cereal) was matched with conventional flaked cereal. participants were instructed to follow an energy restricted diet (-500 kcal/d) and incorporate a test food into each of three meals over a 24-hour period. the diet-induced changes in body mass and lean body mass were tracked as well as changes in in insulin sensitivity and common blood biomarkers.


Eligibility criteria:
inclusion criteria: * 20-75 years of age * bmi 23-42 kg/m2 exclusion criteria: * food allergies * diet restrictions (e.g., vegetarian, gluten or lactose intolerant) * insulin use * cigarette use * active disease states including diagnosed diabetes * anticipated changes to diet or physical activity levels * recent weight gain or loss (±10 pounds) * current or recent pregnancy or lactation * prescription medication use by participants was allowed if use had been consistent